Air Force Radio News

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Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Analysis of data on Air Force personnel collected at Lackland Air Force Base

DOT National Transportation Integrated Search

1969-10-01

In July, 1967, a report was published by the Personnel Research Laboratory, Lackland Air Force Base, entitled "An Attempt to Predict Automobile Accidents Among Air Force Personnnel". Approximately twelve thousand basic airmen and eleven hundred offic...

Air Force officials name SARC of the year > U.S. Air Force > Article

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

Air and Space Power Journal. Volume 16, Number 4, Winter 2002

DTIC Science & Technology

2002-01-01

www.wpafb.af.mil/ museum/research/bombers/ b1 -10.htm. The Oath of Office A Historical Guide to Moral Leadership LT COL KENNETH KESKEL, USAF Editorial...typical of the Royal Air Force (RAF) between the wars, excelling at rugby , boxing, and cricket (in which he was scheduled to compete for England

33 CFR 334.590 - Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base...

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. 334.590 Section 334.590 Navigation... RESTRICTED AREA REGULATIONS § 334.590 Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area... during firing periods to be specified by the Commander, Air Force Missile Test Center, Patrick Air Force...

33 CFR 334.590 - Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base...

Code of Federal Regulations, 2013 CFR

2013-07-01

..., Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. 334.590 Section 334.590 Navigation... RESTRICTED AREA REGULATIONS § 334.590 Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area... during firing periods to be specified by the Commander, Air Force Missile Test Center, Patrick Air Force...

33 CFR 334.590 - Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base...

Code of Federal Regulations, 2012 CFR

2012-07-01

..., Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. 334.590 Section 334.590 Navigation... RESTRICTED AREA REGULATIONS § 334.590 Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area... during firing periods to be specified by the Commander, Air Force Missile Test Center, Patrick Air Force...

33 CFR 334.590 - Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base...

Code of Federal Regulations, 2014 CFR

2014-07-01

..., Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. 334.590 Section 334.590 Navigation... RESTRICTED AREA REGULATIONS § 334.590 Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area... during firing periods to be specified by the Commander, Air Force Missile Test Center, Patrick Air Force...

Finding of No Significant Impact: First Air Force Air Operations Center, First Air Force Headquarters/Air Force Forces Center, and Highway 98 Overpass at Tyndall Air Force Base, Florida

DTIC Science & Technology

2004-11-10

found at the following web address: <http://dep.state.fl.us/air/forms/asbestos.htm#asbestos>. The Air Force is advised to contact Sandra Veazey at...advised to contact Sandra Veazey at (850) 595·8300 for additional information on asbestos issues. http://tlhora6.dep.state.fl.us/clearinghouse/agency

Releasable Asbestos Field Sampler (RAFS) Operation Manual

EPA Science Inventory

The Releasable Asbestos Field Sampler (RAFS) is a field instrument that provides an in-situ measurement of asbestos releasability from consistent and reproducible mechanical agitation of the source material such as soil. The RAFS was designed to measure concentration (asbestos st...

RAF and Intelligence Warfighting Function

DTIC Science & Technology

2015-02-01

Warfighting Function 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...meet the CCDR’s need to leverage the entire Intelligence Enterprise. Balancing IWfF RAF “solutions against an ever reducing budget will require...right balance is important. Using DOTMLPF as a framework can assist in seeing how the IWfF can support RAF implementation. Furthermore, identifying gaps

Air Force Medical Service > Resources > Suicide Prevention

Science.gov Websites

Air Force Medical Service Air Force Medical Service Join the Air Force Home Your Healthcare Healthy Videos MHS Genesis AFMS Priorities Trusted Care Vision Air Force Medical Home Full Spectrum Medical ) Air Force EFMP Who is an EFM? Who must enroll? EFMP-Medical EFMP-M Objectives Family Criteria EFMP-M

Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription

PubMed Central

Yu, Lin; Daniels, Joseph P.; Wu, Huihui; Wolf, Matthew J.

2015-01-01

Organ hypertrophy can result from enlargement of individual cells or from cell proliferation or both. Activating mutations in the serine-threonine kinase Raf cause cardiac hypertrophy and contribute to Noonan syndrome in humans. Cardiac-specific expression of activated Raf also causes hypertrophy in Drosophila melanogaster. We found that Yorkie (Yki), a transcriptional coactivator in the Hippo pathway that regulates organ size, is required for Raf-induced cardiac hypertrophy in flies. Although aberrant activation of Yki orthologs stimulates cardiac hyperplasia in mice, cardiac-specific expression of an activated mutant form of Yki in fruit flies caused cardiac hypertrophy without hyperplasia. Knockdown of Yki caused cardiac dilation without loss of cardiomyocytes and prevented Raf-induced cardiac hypertrophy. In flies, Yki-induced cardiac hypertrophy required the TEA domain–containing transcription factor Scalloped, and, in mammalian cells, expression of mouse RafL613V, an activated form of Raf with a Noonan syndrome mutation, increased Yki-induced Scalloped activity. Furthermore, overexpression of Tgi (a Tondu domain–containing Scalloped-binding corepressor) in the fly heart abrogated Yki- or Raf-induced cardiac hypertrophy. Thus, crosstalk between Raf and Yki occurs in the heart and can influence Raf-mediated cardiac hypertrophy. PMID:25650441

C-RAF function at the genome-wide transcriptome level: A systematic view.

PubMed

Huang, Ying; Zhang, Xin-Yu; An, Su; Yang, Yang; Liu, Ying; Hao, Qian; Guo, Xiao-Xi; Xu, Tian-Rui

2018-05-20

C-RAF was the first member of the RAF kinase family to be discovered. Since its discovery, C-RAF has been found to regulate many fundamental cell processes, such as cell proliferation, cell death, and metabolism. However, the majority of these functions are achieved through interactions with different proteins; the genes regulated by C-RAF in its active or inactive state remain unclear. In the work, we used RNA-seq analysis to study the global transcriptomes of C-RAF bearing or C-RAF knockout cells in quiescent or EGF activated states. We identified 3353 genes that are promoted or suppressed by C-RAF. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that these genes are involved in drug addiction, cardiomyopathy, autoimmunity, and regulation of cell metabolism. Our results provide a panoramic view of C-RAF function, including known and novel functions, and have revealed potential targets for elucidating the role of C-RAF. Copyright © 2018 Elsevier B.V. All rights reserved.

32 CFR 855.22 - Air Force procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Air Force procedures. 855.22 Section 855.22 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855...

32 CFR 855.22 - Air Force procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Air Force procedures. 855.22 Section 855.22 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855...

32 CFR 855.22 - Air Force procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Air Force procedures. 855.22 Section 855.22 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Agreements for Civil Aircraft Use of Air Force Airfields § 855...

U.S. Air Force > SAPR

Science.gov Websites

for treatment in the military health system, and Air Force civilian (appropriated and non-appropriated (or equivalent) or installation vice wing commander, executing the Air Force's Sexual Assault

Viral oncolysis that targets Raf-1 signaling control of nuclear transport.

PubMed

Riolobos, Laura; Valle, Noelia; Hernando, Eva; Maroto, Beatriz; Kann, Michael; Almendral, José M

2010-02-01

The central role of Raf protein kinase isoforms in human cancer demands specific anti-Raf therapeutic inhibitors. Parvoviruses are currently used in experimental cancer therapy due to their natural oncotropism and lytic life cycle. In searching for mechanisms underlying parvovirus oncolysis, we found that trimers of the major structural protein (VP) of the parvovirus minute virus of mice (MVM), which have to be imported into the nucleus for capsid assembly, undergo phosphorylation by the Raf-1 kinase. Purified Raf-1 phosphorylated the capsid subunits in vitro to the two-dimensional pattern found in natural MVM infections. VP trimers isolated from mammalian cells translocated into the nucleus of digitonin-permeabilized human cells. In contrast, VP trimers isolated from insect cells, which are devoid of Raf-1, were neither phosphorylated nor imported into the mammalian nucleus. However, the coexpression of a constitutively active Raf-1 kinase in insect cells restored VP trimer phosphorylation and nuclear transport competence. In MVM-infected normal and transformed cells, Raf-1 inhibition resulted in cytoplasmic retention of capsid proteins, preventing their nuclear assembly and progeny virus maturation. The level of Raf-1 activity in cancer cells was consistent with the extent of VP specific phosphorylation and with the permissiveness to MVM infection. Thus, Raf-1 control of nuclear translocation of MVM capsid assembly intermediates provides a novel target for viral oncolysis. MVM may reinforce specific therapies against frequent human cancers with deregulated Raf signaling.

33 CFR 334.590 - Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. 334.590 Section 334.590 Navigation... RESTRICTED AREA REGULATIONS § 334.590 Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. (a) The danger zone. An area in the Atlantic Ocean immediately offshore from...

Inspector General, DoD, Oversight of the Air Force Audit Agency Audit of the FY 1996 Air Force Consolidated Financial Statements.

DTIC Science & Technology

1997-04-10

financial statements . We delegated the audit of the FY 1996 Air Force consolidated financial statements to the Air Force Audit Agency on May 17, 1996...This report provides our endorsement of the Air Force Audit Agency disclaimer of opinion on the Air Force consolidated financial statements for FY...1996, along with the Air Force Audit Agency Report of Audit, ’Opinion on Fiscal Year 1996 Air Force Consolidated Financial Statements .’

Secretary of the Air Force

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Air Force Research Laboratory Preparation for Year 2000.

DTIC Science & Technology

1998-10-05

Air Force Research Laboratory , Phillips Research Site , Kirkland Air Force Base, New...Pentagon, Washington, D.C. 20301-1900. The identity of each writer and caller is fully protected. Acronym AFRL Air Force Research Laboratory INSPECTOR...completion of the implementation phase was May 31, 1999. Air Force Research Laboratory . The Air Force Research

Environmental Assessment, Balloon Launch and Landing Operations, Air Force Research Laboratory, Space Vehicles Directorate, Kirtland Air Force Base, New Mexico

DTIC Science & Technology

2012-06-01

Force Research Laboratory , Space Vehicles Directorate ( AFRL /RV) located at Kirtland Air Force Base is preparing an Environmental Assessment (EA) for...United States Air Force Research Laboratory , Space Vehicles Directorate ( AFRL /RV) located at Kirtland Air Force Base is preparing an Environmental...United States Air Force Research Laboratory , Space Vehicles Directorate ( AFRL

List of EPA Certified Forced-Air Furnaces

EPA Pesticide Factsheets

The EPA-Certified Forced-Air Furnace list contains EPA-certified forced-air furnaces that meet the 2015 NSPS for New Residential Wood Heaters, New Residential Hydronic Heaters and Forced-Air Furnaces.

The Air Force Nurse Intern Program.

PubMed

Smith, R H

1991-08-01

The Air Force Nurse Intern Program is a 5-month-long introduction to Air Force nursing for BSN-prepared graduate nurses. The program is designed to facilitate the transition from civilian nursing student to practicing Air Force Nurse Corps Officer. After attending Military Indoctrination for Medical Service Officers, newly commissioned nurses attend the program at one of 10 Air Force medical centers before going to their permanent duty stations. Preceptors guide and instruct the interns at each of four clinical rotation sites. The author, a former nurse intern, describes some of the many opportunities available to nurse interns.

p21 Activated Kinase 5 Activates Raf-1 and Targets it to Mitochondria

PubMed Central

Wu, Xiaochong; Carr, Heather S.; Dan, Ippeita; Ruvolo, Peter P.; Frost, Jeffrey A.

2008-01-01

Raf-1 is an important effector of Ras mediated signaling and is a critical regulator of the ERK/MAPK pathway. Raf-1 activation is controlled in part by phosphorylation on multiple residues, including an obligate phosphorylation site at serine 338. Previously PAK1 and casein kinase II have been implicated as serine 338 kinases. To identify novel kinases that phosphorylate this site, we tested the ability of group II PAKs (PAKs 4-6) to control serine 338 phosphorylation. We observed that all group II PAKs were efficient serine 338 kinases, although only PAK1 and PAK5 significantly stimulated Raf-1 kinase activity. We also showed that PAK5 forms a tight complex with Raf-1 in the cell, but not A-Raf or B-Raf. Importantly, we also demonstrated that the association of Raf-1 with PAK5 targets a subpopulation of Raf-1 to mitochondria. These data indicate that PAK5 is a potent regulator of Raf-1 activity and may control Raf-1 dependent signaling at the mitochondria. PMID:18465753

Inspector General, DOD, Oversight of the Air Force Audit Agency Audit of the FY 1995 Air Force Consolidated Financial Statements.

DTIC Science & Technology

1996-04-18

financial statements . We delegated the audit of the FY 1995 Air Force consolidated financial statements to the Air Force Audit Agency. On March 1...1996, the Air Force Audit Agency issued its "Report of Audit: Opinion on Fiscal Year 1995 Air Force Consolidated Financial Statements " (Project 94053001...disclaimer of opinion. The audit objective was to determine the accuracy and completeness of the audit of the FY 1995 Air Force consolidated financial statements conducted

The Tumor Suppressor DiRas3 Forms a Complex with H-Ras and C-RAF Proteins and Regulates Localization, Dimerization, and Kinase Activity of C-RAF*

PubMed Central

Baljuls, Angela; Beck, Matthias; Oenel, Ayla; Robubi, Armin; Kroschewski, Ruth; Hekman, Mirko; Rudel, Thomas; Rapp, Ulf R.

2012-01-01

The maternally imprinted Ras-related tumor suppressor gene DiRas3 is lost or down-regulated in more than 60% of ovarian and breast cancers. The anti-tumorigenic effect of DiRas3 is achieved through several mechanisms, including inhibition of cell proliferation, motility, and invasion, as well as induction of apoptosis and autophagy. Re-expression of DiRas3 in cancer cells interferes with the signaling through Ras/MAPK and PI3K. Despite intensive research, the mode of interference of DiRas3 with the Ras/RAF/MEK/ERK signal transduction is still a matter of speculation. In this study, we show that DiRas3 associates with the H-Ras oncogene and that activation of H-Ras enforces this interaction. Furthermore, while associated with DiRas3, H-Ras is able to bind to its effector protein C-RAF. The resulting multimeric complex consisting of DiRas3, C-RAF, and active H-Ras is more stable than the two protein complexes H-Ras·C-RAF or H-Ras·DiRas3, respectively. The consequence of this complex formation is a DiRas3-mediated recruitment and anchorage of C-RAF to components of the membrane skeleton, suppression of C-RAF/B-RAF heterodimerization, and inhibition of C-RAF kinase activity. PMID:22605333

Remodeling Air Force Cyber Command and Control

DTIC Science & Technology

2017-10-10

AIR FORCE CYBERWORX REPORT: REMODELING AIR FORCE CYBER COMMAND & CONTROL COURSE DESIGN PROJECT CONDUCTED 5 Jan – 5 May 17 Produced...For the Air Force Cyber Command and Control (C2) Design Project, CyberWorx brought together 25 cadets from the United States Air Force Academy...warfighting based upon the findings of the design teams. Participants The design course was attended by a diverse group of civilians from industry

33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

Code of Federal Regulations, 2012 CFR

2012-07-01

... weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. (a... enforced by the Commander, Alaskan Air Command, U.S. Air Force, Seattle, Washington, or such agencies as he...

33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

Code of Federal Regulations, 2013 CFR

2013-07-01

... weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. (a... enforced by the Commander, Alaskan Air Command, U.S. Air Force, Seattle, Washington, or such agencies as he...

33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

Code of Federal Regulations, 2014 CFR

2014-07-01

... weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. (a... enforced by the Commander, Alaskan Air Command, U.S. Air Force, Seattle, Washington, or such agencies as he...

33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

Code of Federal Regulations, 2010 CFR

2010-07-01

... weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. (a... enforced by the Commander, Alaskan Air Command, U.S. Air Force, Seattle, Washington, or such agencies as he...

33 CFR 334.1280 - Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force.

Code of Federal Regulations, 2011 CFR

2011-07-01

... weapon range, Alaskan Air Command, U.S. Air Force. 334.1280 Section 334.1280 Navigation and Navigable... REGULATIONS § 334.1280 Bristol Bay, Alaska; air-to-air weapon range, Alaskan Air Command, U.S. Air Force. (a... enforced by the Commander, Alaskan Air Command, U.S. Air Force, Seattle, Washington, or such agencies as he...

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

PubMed

Johannessen, Cory M; Boehm, Jesse S; Kim, So Young; Thomas, Sapana R; Wardwell, Leslie; Johnson, Laura A; Emery, Caroline M; Stransky, Nicolas; Cogdill, Alexandria P; Barretina, Jordi; Caponigro, Giordano; Hieronymus, Haley; Murray, Ryan R; Salehi-Ashtiani, Kourosh; Hill, David E; Vidal, Marc; Zhao, Jean J; Yang, Xiaoping; Alkan, Ozan; Kim, Sungjoon; Harris, Jennifer L; Wilson, Christopher J; Myer, Vic E; Finan, Peter M; Root, David E; Roberts, Thomas M; Golub, Todd; Flaherty, Keith T; Dummer, Reinhard; Weber, Barbara L; Sellers, William R; Schlegel, Robert; Wargo, Jennifer A; Hahn, William C; Garraway, Levi A

2010-12-16

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has been validated by the success of RAF and MEK inhibitors in clinical trials. However, clinical responses to targeted anticancer therapeutics are frequently confounded by de novo or acquired resistance. Identification of resistance mechanisms in a manner that elucidates alternative 'druggable' targets may inform effective long-term treatment strategies. Here we expressed ∼600 kinase and kinase-related open reading frames (ORFs) in parallel to interrogate resistance to a selective RAF kinase inhibitor. We identified MAP3K8 (the gene encoding COT/Tpl2) as a MAPK pathway agonist that drives resistance to RAF inhibition in B-RAF(V600E) cell lines. COT activates ERK primarily through MEK-dependent mechanisms that do not require RAF signalling. Moreover, COT expression is associated with de novo resistance in B-RAF(V600E) cultured cell lines and acquired resistance in melanoma cells and tissue obtained from relapsing patients following treatment with MEK or RAF inhibitors. We further identify combinatorial MAPK pathway inhibition or targeting of COT kinase activity as possible therapeutic strategies for reducing MAPK pathway activation in this setting. Together, these results provide new insights into resistance mechanisms involving the MAPK pathway and articulate an integrative approach through which high-throughput functional screens may inform the development of novel therapeutic strategies.

Environmental Assessment for Air Force Research Laboratory Space Vehicles Integrated Experiments Division Office Space at Kirtland Air Force Base, Albuquerque, New Mexico

DTIC Science & Technology

2005-06-01

AIR FORCE RESEARCH LABORATORY SPACE VEHICLES INTEGRATED EXPERMENTS DIVISION OFFICE SPACE AT KIRTLAND AIR FORCE ... Kirtland Air Force Base (KAFB). The office building would house the Air Force Research Laboratory Space Vehicles Integrated Experiments Division...ADDRESS(ES) Air Force Research Laboratory ,Space Vehicles Directorate,3550 Aberdeen Ave. SE, Kirtland

Historical Lessons of Air Force Communications

DTIC Science & Technology

2010-12-01

AU/ACSC/ CUSTINE /AY10 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY HISTORICAL LESSONS OF AIR FORCE COMMUNICATIONS...by Jay D. Custine , Civ, DAF A Research Report Submitted to the Faculty In Partial Fulfillment of the Graduation...Requirements Advisor: Lt Col Paul E. Griffith Maxwell Air Force Base, Alabama December 2010 AU/ACSC/ CUSTINE /AY10 ii

Survival Analysis of US Air Force Officer Retention Rate

DTIC Science & Technology

2017-03-23

Air Force Institute of Technology AFIT Scholar Theses and Dissertations 3-23-2017 Survival Analysis of US Air Force Officer Retention Rate Courtney N...AIR UNIVERSITY AIR FORCE INSTITUTE OF TECHNOLOGY Wright-Patterson Air Force Base, Ohio DISTRIBUTION STATEMENT A. APPROVED FOR PUBLIC RELEASE...to the Faculty Department of Operational Sciences Graduate School of Engineering and Management Air Force Institute of Technology Air University

Rebalancing the Air Force: A Comprehensive Solution

DTIC Science & Technology

2011-02-16

the consequences can be significant. High Tempo (Figure 4) Lt Gen Charles E. Stenner , Jr., Chief of the Air Force Reserve, stated while...29 January 2010. 14 Lt Gen Charles E. Stenner Jr., Chief of the Air Force Reserve, ―Total Force Policy 21: A 21 st Century Framework for...Military Force Mix Decisions,‖ White Paper, 15 July 2010. 15 Lt Gen Charles E. Stenner Jr., Chief of the Air Force Reserve, ―Testimony Before the House

Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence

PubMed Central

Fujimoto, Mai; Mano, Yasunobu; Anai, Motonobu; Yamamoto, Shogo; Fukuyo, Masaki; Aburatani, Hiroyuki; Kaneda, Atsushi

2016-01-01

AIM: To investigate epigenomic and gene expression alterations during cellular senescence induced by oncogenic Raf. METHODS: Cellular senescence was induced into mouse embryonic fibroblasts (MEFs) by infecting retrovirus to express oncogenic Raf (RafV600E). RNA was collected from RafV600E cells as well as MEFs without infection and MEFs with mock infection, and a genome-wide gene expression analysis was performed using microarray. The epigenomic status for active H3K4me3 and repressive H3K27me3 histone marks was analyzed by chromatin immunoprecipitation-sequencing for RafV600E cells on day 7 and for MEFs without infection. These data for Raf-induced senescence were compared with data for Ras-induced senescence that were obtained in our previous study. Gene knockdown and overexpression were done by retrovirus infection. RESULTS: Although the expression of some genes including secreted factors was specifically altered in either Ras- or Raf-induced senescence, many genes showed similar alteration pattern in Raf- and Ras-induced senescence. A total of 841 commonly upregulated 841 genes and 573 commonly downregulated genes showed a significant enrichment of genes related to signal and secreted proteins, suggesting the importance of alterations in secreted factors. Bmp2, a secreted protein to activate Bmp2-Smad signaling, was highly upregulated with gain of H3K4me3 and loss of H3K27me3 during Raf-induced senescence, as previously detected in Ras-induced senescence, and the knockdown of Bmp2 by shRNA lead to escape from Raf-induced senescence. Bmp2-Smad inhibitor Smad6 was strongly repressed with H3K4me3 loss in Raf-induced senescence, as detected in Ras-induced senescence, and senescence was also bypassed by Smad6 induction in Raf-activated cells. Different from Ras-induced senescence, however, gain of H3K27me3 did not occur in the Smad6 promoter region during Raf-induced senescence. When comparing genome-wide alteration between Ras- and Raf-induced senescence, genes

Air Force Historical Research Agency

Science.gov Websites

Command Capt Joseph J Merhar Jr collection Early Wright Brothers Flying Machines History of the 3rd Organizations Wings and Groups Squadrons and Flights Studies Documents Personal Papers Oral History Catalogue S. Fairchild Research Information Center Military Sites Air Force Link DefenseLINK Air Force History

32 CFR 855.22 - Air Force procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Air Force procedures. 855.22 Section 855.22 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE... is located. AFI 13-201, Air Force Airspace Management, 8 lists the AFREPs and their addresses. The...

32 CFR 855.22 - Air Force procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Air Force procedures. 855.22 Section 855.22 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE... is located. AFI 13-201, Air Force Airspace Management, 8 lists the AFREPs and their addresses. The...

32 CFR 631.15 - Air Force policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 4 2014-07-01 2013-07-01 true Air Force policy. 631.15 Section 631.15 National...-Installation Operations (Military Patrols and Investigative Activities) and Policy § 631.15 Air Force policy. (a) Airmen, military and/or Department of the Air Force Civilian (DAFC) police performing off...

32 CFR 631.15 - Air Force policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 4 2013-07-01 2013-07-01 false Air Force policy. 631.15 Section 631.15 National...-Installation Operations (Military Patrols and Investigative Activities) and Policy § 631.15 Air Force policy. (a) Airmen, military and/or Department of the Air Force Civilian (DAFC) police performing off...

32 CFR 631.15 - Air Force policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Air Force policy. 631.15 Section 631.15 National...-Installation Operations (Military Patrols and Investigative Activities) and Policy § 631.15 Air Force policy. (a) Airmen, military and/or Department of the Air Force Civilian (DAFC) police performing off...

Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, James; Bunaciu, Rodica P.; Reiterer, Gudrun

All trans-retinoic acid (RA) is a standard therapeutic agent used in differentiation induction therapy treatment of acute promyelocytic leukemia (APL). RA and its metabolites use a diverse set of signal transduction pathways during the differentiation program. In addition to the direct transcriptional targets of the nuclear RAR and RXR receptors, signals derived from membrane receptors and the Raf-MEK-ERK pathway are required. Raf1 phosphorylation and the prolonged activation of Raf1 persisting during the entire differentiation process are required for RA-dependent differentiation of HL-60 cells. Here we identify a nuclear redistribution of Raf1 during the RA-induced differentiation of HL-60 cells. In addition,more » the nuclear accumulation of Raf1 correlates with an increase in Raf1 phosphorylated at serine 621. The serine 621 phosphorylated Raf1 is predominantly localized in the nucleus. The RA-dependent nuclear accumulation of Raf1 suggests a novel nuclear role for Raf1 during the differentiation process.« less

Final Environmental Assessment for the First Air Force Air Operations Center, First Air Force Headquarters/Air Force Forces Center, and Highway 98 Overpass at Tyndall Air Force Base, Florida

DTIC Science & Technology

2004-01-01

to contact Sandra Veazey at (850) 595-8300 for additional information on asbestos issues. The Florida Department of Transportation (FDOT) supports...The notification form for the Department can be found at the following web address:. The Air Force is advised to contact Sandra Veazey at (850) 595

B-Raf mutation: a key player in molecular biology of cancer.

PubMed

Rahman, M A; Salajegheh, A; Smith, R A; Lam, A K-Y

2013-12-01

B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations in cancer and discuss the implications for the patient in melanoma, thyroid cancer and colorectal cancer, where B-Raf mutations are particularly common. © 2013.

Air Force UAVs: The Secret History

DTIC Science & Technology

2010-07-01

iA Mitchell Institute Study i Air Force UAVs The Secret History A Mitchell Institute Study July 2010 By Thomas P. Ehrhard Report Documentation Page...DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Air Force UAVs The Secret History 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...opening phases of Operation Enduring Freedom in Afghanistan. By Thomas P. Ehrhard a miTchEll insTiTuTE sTudy July 2010 Air Force UAVs The Secret History

32 CFR 842.11 - Air Force claims organization.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Air Force claims organization. 842.11 Section 842.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION ADMINISTRATIVE CLAIMS Functions and Responsibilities § 842.11 Air Force claims organization. Air...

32 CFR 842.11 - Air Force claims organization.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Air Force claims organization. 842.11 Section 842.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION ADMINISTRATIVE CLAIMS Functions and Responsibilities § 842.11 Air Force claims organization. Air...

32 CFR 842.11 - Air Force claims organization.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Air Force claims organization. 842.11 Section 842.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION ADMINISTRATIVE CLAIMS Functions and Responsibilities § 842.11 Air Force claims organization. Air...

Air Force Office of Scientific Research 1991 Research Highlights

DTIC Science & Technology

1991-01-01

research at Air Force Europe, allied victory in the Persian Gulf con- programs totaling nearly $300 million annual- laboratories . Air Force ...transitioning nological environment? laboratories and research centers into four research accomplishments for Air Force use. In this added role as... Air Force’s saries; maintaining a strong research Organizationally, AFOSR has also glo ehran gol per infrastructure among Air Force

Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond

PubMed Central

Holderfield, Matthew; Deuker, Marian M.; McCormick, Frank; McMahon, Martin

2014-01-01

The identification of mutationally activated BRAF in many cancers altered our conception of the role played by the RAF family of protein kinases in oncogenesis. In this review we describe the development of BRAF inhibitors and the results that have emerged from their analysis in both the laboratory and the clinic. We discuss the spectrum of RAF mutations in human cancer and the complex interplay between tissue of origin and response to RAF inhibition. Finally, we enumerate mechanisms of resistance to BRAF inhibition that have been characterized and postulate how strategies of RAF pathway inhibition may be extended in scope to benefit, not only the thousands of patients diagnosed annually with BRAF-mutated metastatic melanoma, but also the larger patient population with malignancies harboring mutationally activated RAF genes that is ineffectively treated with the current generation of BRAF kinase inhibitors. PMID:24957944

Air Force Special Operations Command > Home > POTFF

Science.gov Websites

Air Force Special Operations Command Air Force Special Operations Command Join the Air Force Home Sheets AFSOC Senior Leaders AFSOC Heritage Units 1st Special Operations Wing 24th Special Operations Wing 27th Special Operations Wing 352nd Special Operations Wing 353rd Special Operations Group 492nd Special

Reducing Air Force Fighter Pilot Shortages

DTIC Science & Technology

2015-12-31

that active-component fighter pilot requirements (particularly nonflying staff requirements) exceed its capacity to train and provide initial...pilots in the reserve components. This research was sponsored by four elements of the U.S. Air Force: the Deputy Chief of Staff for Operations (AF/A3...the Deputy Chief of Staff for Manpower, Personnel and Services (AF/A1); the Commander, Air Force Reserve Command (AFRC/CC); and the Director, Air

Air Force UAV’s: The Secret History

DTIC Science & Technology

2010-07-01

iA Mitchell Institute Study i Air Force UAVs The Secret History A Mitchell Institute Study July 2010 By Thomas P. Ehrhard Report Documentation Page...DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Air Force UAVs The Secret History 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c... The Secret History 2 Air Force UAVs: The Secret History2 air Force uaVs: The secret history Has any airplane in the past decade captured the public

Air Force Audit Agency Management Information System

DTIC Science & Technology

1990-11-01

Support Directorate. AFAA/QL performs multilocation . Air Force-wide audits and issues reports to the SAF. It, however, specializes in the multibillion...USE ONLY (Leave blank) 2. REPORT DATE 3. REPORT TYPE AND DATES COVERED NOV 90 4. TITLE AND SUBTITLE S. FUNDING NUMBERS Air Force Audit Agency...appreciated. Mail them to: CADRE/RI, Building 1400, Maxwell AFB AL 36112-5532.• Air Force Audit Agency Management Hobbs Information System C 0* 0 0

Air Force Research Laboratory’s Focused Long Term Challenges

DTIC Science & Technology

2008-04-01

Air Force Research Laboratory ( AFRL ) mission is to provide support to the Air Force (AF) and the warfighters with... Air Force Research Laboratory’s Focused Long Term Challenges Leo J Rose Munitions Directorate, Air Force Research Laboratory , 101 W Eglin Blvd...This technology vision, which was born in our Air Force Research Laboratory , builds on the Air Force’s traditional kill

NASA/Air Force Cost Model: NAFCOM

NASA Technical Reports Server (NTRS)

Winn, Sharon D.; Hamcher, John W. (Technical Monitor)

2002-01-01

The NASA/Air Force Cost Model (NAFCOM) is a parametric estimating tool for space hardware. It is based on historical NASA and Air Force space projects and is primarily used in the very early phases of a development project. NAFCOM can be used at the subsystem or component levels.

The Soviet Air Force and Strategic Bombing

DTIC Science & Technology

1999-04-01

to envision a British Air Force that could be totally divorced from some form of ground support role. Consequently, he saw an air campaign that would...CA: Presidio Press, 1986. Black, Steven K. The Icarus Illusion: Technology, Doctrine and the Soviet Air Force. Monterrey , CA, 1986. Cockburn, Andrew

32 CFR 631.15 - Air Force policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Air Force policy. 631.15 Section 631.15 National... INVESTIGATIONS ARMED FORCES DISCIPLINARY CONTROL BOARDS AND OFF-INSTALLATION LIAISON AND OPERATIONS Off-Installation Operations (Military Patrols and Investigative Activities) and Policy § 631.15 Air Force policy...

Mutations that abolish the ability of Ha-Ras to associate with Raf-1.

PubMed

Shirouzu, M; Koide, H; Fujita-Yoshigaki, J; Oshio, H; Toyama, Y; Yamasaki, K; Fuhrman, S A; Villafranca, E; Kaziro, Y; Yokoyama, S

1994-08-01

Recent studies have revealed that Ras can associate physically with Raf. In the present study, we tested 34 mutants of Ha-Ras carrying substitution(s) in the region of residues 23-71 for their ability to associate with Raf-1. Mouse Ba/F3 cell lysates were incubated with each mutant Ras protein, in either the guanosine 5'-[gamma-thio]triphosphate (GTP gamma S)- or the guanosine 5'-[beta-thio]diphosphate (GDP beta S)-bound form, and the anti-Ras antibody Y13-238. The immunoprecipitates were analysed for the presence of Raf-1 by Western blotting with an anti-Raf-1 antibody. Six mutants of Ras, E31K, P34G, T35S, D38N, D57A and A59T, failed to bind Raf-1. Mutations N26G, V29A, S39A, Y40W, R41A, V44A, V45E, L56A and T58A partially reduced the ability to bind Raf-1. All the other mutants could associate with Raf-1 with nearly the same efficiency as that of wild-type Ras. Thus, the Raf-I-binding ability of Ras appears to be affected by mutations in the N-terminal region, and in particular, by those in and neighboring the effector region (residues 32-40) and in the region (residues 56-59) flanking the N-terminal of Switch II. The abilities to bind Raf-1 and to induce neurite outgrowth of pheochromocytoma (PC) 12 cells correlate to each other for 22 Ras mutants. However, mutation A59T, which does not reduce the neurite-inducing or transforming activities, abolishes the ability to bind Raf-1. In contrast, mutations Y32F, K42A and L53A, which impair the neurite-inducing activity of Ras, have no effect on the Ras.Raf-1 association. Partially reduced Raf-1-binding ability was observed for mutants V29A, S39A, Y40W, R41A, V44A, L56A and T58A, which exhibit full neurite-inducing activity, and also for mutant V45E, which has no activity of neurite induction.

77 FR 33202 - Department of the Air Force

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... DEPARTMENT OF DEFENSE Department of the Air Force Corrected Intent To Grant a Partially Exclusive Patent License AGENCY: The United States Air Force, DoD. SUMMARY: This notice replaces the one published... implements Public Law 96- 517, as amended; the Department of the Air Force announces its intention to grant...

Air Force Technical Objective Document FY 87

DTIC Science & Technology

1985-12-01

Air Force Systems Command Edwards Air Force Base. Cal ifornia 93523-5000 NOTICES THIS DOCUMENT IS FOR INFORMATION AND GUIDANCE ONL Y This...acquisition of Air Foree weapon systems . Each Air Foree laboratory annually formulates Q Research and Technology (R& T) Pion in response to available...guidance based on USAF requirements, the identification of scientific and technological opportunities, and the needs of present and projected systems

Air Force seal activities

NASA Astrophysics Data System (ADS)

Mayhew, Ellen R.

1994-07-01

Seal technology development is an important part of the Air Force's participation in the Integrated High Performance Turbine Engine Technology (IHPTET) initiative, the joint DOD, NASA, ARPA, and industry endeavor to double turbine engine capabilities by the turn of the century. Significant performance and efficiency improvements can be obtained through reducing internal flow system leakage, but seal environment requirements continue to become more extreme as the engine thermodynamic cycles advance towards these IHPTET goals. Brush seal technology continues to be pursued by the Air Force to reduce leakage at the required conditions. Likewise, challenges in engine mainshaft air/oil seals are also being addressed. Counter-rotating intershaft applications within the IHPTET initiative involve very high rubbing velocities. This viewgraph presentation briefly describes past and current seal research and development programs and gives a summary of seal applications in demonstrator and developmental engine testing.

Canadian Air Force Leadership and Command: Implications for the Human Dimension of Expeditionary Air Force Operations

DTIC Science & Technology

2006-11-01

Project Manager : CSA: Angela Febbraro The scientific or technical validity of this Contract Report is entirely the responsibility of the...ways, for example, in leadership styles and command arrangements. Unfortunately for the Canadian Air Force, very little has been written about how its...culture and professional working environment have influenced the development of unique Canadian air force leadership styles and command

Air Force and Diversity: The Awkward Embrace

DTIC Science & Technology

2013-02-14

Streeter is a U.S. Air Force intelligence officer assigned to the Air War College, Air University, Maxwell AFB, AL. She graduated from the United States...future leaders.” Princeton University Office of Human Resources Web site; Wilson et al, Grooming Top Leaders, 4. 28 45. Dr Fil J . Arenas...Air Force Diversity Strategic Roadmap (2012), 14. 86. Dr. Fil J . Arenas (Associate Professor, Organizational Leadership Studies, Squadron

Air Force Weapons Laboratory Computational Requirements for 1976 Through 1980

DTIC Science & Technology

1976-01-01

Air Force Weapons Laboratory , Attn: DYS, Kirtland AFB, NM 87117...final report was prepared by the Air Force Weapons Laboratory , Kirtland Air Force Base, New Mexico under Job Order 06CB. Dr. Clifford E. Rhoades, Jr... Force Base, New Mexico 87117 62601F, 06CB II. CONTROLLING OFFICE NAME AND ADDRESS Ai"- Force Weapons Laboratory / Jan 1076 Kirtland Air Force Base,

Securing the High Ground: Dominant Combat Air Force for America. 2008 Combat Air Force Strategic Plan

DTIC Science & Technology

2008-07-28

continue to be beyond our technical ability to realize aggresively pursue advanced technical solutions to stay at the leading edge of technological...inherent to each caf Way and to seek continual improvement through exploration of innovative concepts, advanced capabilities, game -changing...available online at the air force portal: https://wwwd.my.af.mil/afknprod/strat_plan COMBAT AIR FORCE STRATEGIC PLAN Points of Contact securing the high

Cognitive Evaluation of Israeli Air Force Pilot Cadets.

PubMed

Gordon, Shirley; Goren, Chen; Carmon, Erez; Shelef, Leah

2017-04-01

In aviation psychology, there is a constant need for the cognitive evaluation of pilots as part of operational fitness and safety criteria. A cross-sectional study with comparison between the performance of Israeli Air Force pilot cadets (N = 318) and U.S. Air Force pilot training candidates (N = 512) as assessed by a cognitive battery was undertaken. The data of the comparison group was collected from Callister, King, and Retzlaff, as published in 1996. In general, the means in the three components composing the battery-speed, accuracy, and throughput variables-indicated that the Israeli Air Force pilot cadets' scores were higher than those of the U.S. Air Force pilot candidates' scores in 50 of 53 variables. Nonsignificant differences were found in Accuracy of shifting attention-arrow color (SATAC), pathfinder-combined (PFC), and pathfinder-letter (PFL). The difference in performance between the two groups may be due to differences in population characteristics. However, these results need to be considered cautiously, as the groups were sampled at a sizeable time gap (1996 for the U.S. Air Force vs. 2013 for the Israeli Air Force), with each time period characterized by different cultural and technological influences.Gordon S, Goren C, Carmon E, Shelef L. Cognitive evaluation of Israeli Air Force pilot cadets. Aerosp Med Hum Perform. 2017; 88(4):392-398.

Chief of Staff of the Air Force

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Chief Master Sergeant of the Air Force

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Air Force Integrated Personnel and Pay System (AFIPPS)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Air Force Integrated Personnel and Pay System (AFIPPS) Defense Acquisition Management...DSN Fax: 665-1207 Date Assigned: February 1, 2016 Program Information Program Name Air Force Integrated Personnel and Pay System (AFIPPS) DoD...therefore, no Original Estimate has been established. AFIPPS 2016 MAR UNCLASSIFIED 4 Program Description Air Force Integrated Personnel and Pay

[Effects of electromagnetic radiation on RAF/MEK/ERK signaling pathway in rats hippocampus].

PubMed

Zuo, Hong-yan; Wang, De-wen; Peng, Rui-yun; Wang, Shui-ming; Gao, Ya-bing; Xu, Xin-ping; Ma, Jun-Jie

2009-05-01

To study the development of changes for signaling molecules related to Raf/MEK/ERK pathway in hippocampus of rats after electromagnetic radiation, and investigate the mechanisms of radiation injury. Rats were exposed to X-HPM, S-HPM and EMP radiation source respectively, and animal model of electromagnetic radiation was established. Western blot was used to detect the expression of Raf-1, phosphorylated Raf-1 and phospholylated ERK. The expression of Raf-1 down-regulated during 6 h-14 d after radiation, most significantly at 7 d, and recovered at 28 d. There was no significant difference between the radiation groups. The expression of phosphorylated Raf-1 and phosphorylated ERK both up-regulated at 6 h and 7 d after radiation, more significantly at 6 h, and the two microwave groups were more serious for phosphorylated ERK. During 6 h-14 d after S-HPM radiation, the expression of phosphorylated Raf-1 increased continuously, but phosphorylated ERK changed wavily, 6 h and 7 d were expression peak. Raf/MEK/ERK signaling pathway participates in the hippocampus injury induced by electromagnetic radiation. The excessive activation of ERK pathway may result in the apoptosis and death of neurons, which is the important mechanism of recognition disfunction caused by electromagnetic radiation.

Increased BRAF Heterodimerization Is the Common Pathogenic Mechanism for Noonan Syndrome-Associated RAF1 Mutants

PubMed Central

Wu, Xue; Yin, Jiani; Simpson, Jeremy; Kim, Kyoung-Han; Gu, Shengqing; Hong, Jenny H.; Bayliss, Peter; Backx, Peter H.

2012-01-01

Noonan syndrome (NS) is a relatively common autosomal dominant disorder characterized by congenital heart defects, short stature, and facial dysmorphia. NS is caused by germ line mutations in several components of the RAS–RAF–MEK–extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway, including both kinase-activating and kinase-impaired alleles of RAF1 (∼3 to 5%), which encodes a serine-threonine kinase for MEK1/2. To investigate how kinase-impaired RAF1 mutants cause NS, we generated knock-in mice expressing Raf1D486N. Raf1D486N/+ (here D486N/+) female mice exhibited a mild growth defect. Male and female D486N/D486N mice developed concentric cardiac hypertrophy and incompletely penetrant, but severe, growth defects. Remarkably, Mek/Erk activation was enhanced in Raf1D486N-expressing cells compared with controls. RAF1D486N, as well as other kinase-impaired RAF1 mutants, showed increased heterodimerization with BRAF, which was necessary and sufficient to promote increased MEK/ERK activation. Furthermore, kinase-activating RAF1 mutants also required heterodimerization to enhance MEK/ERK activation. Our results suggest that an increased heterodimerization ability is the common pathogenic mechanism for NS-associated RAF1 mutations. PMID:22826437

The Air Land Sea Bulletin. Issue Number 2007-2, May 2007

DTIC Science & Technology

2007-05-01

the SCAR role the GR4 can be equipped with unguided 1,000 lb high/low drag weap- ons, GPS/laser-guided bombs, Brimstone anti- armour weapons, and a...Reconnaissance ( SCAR ) and the revision of our core publica- tion, Joint Application of Firepower (JFIRE). Both projects should be in print and in...sance or SCAR as it is known has been a core capability of the Royal Air Force (RAF) ground attack aircraft for many years but recent conflicts

Pacific Air Forces > Home

Science.gov Websites

headquarters staff at Joint Base Pearl Harbor-Hickam, Hawaii, May 16, 2016. U.S. Air Force Maj. Gen. Russell L Tarin Punsri (center left), and attendees pose for a photo in the Courtyard of Heroes at Joint Base commander's call at Misawa Air Base, Japan, May 11, 2018. The general highlighted the strategic importance of

Aviators and Air Combat: A Study of the U.S. Eighth Air Force and R.A.F. Bomber Command

DTIC Science & Technology

1992-07-01

These were the human qualities, above all others, that air war seemed to demand . The reasons for this are apparent from the nature of the conflict. If we...are fundamentally similar with respect to the human dimension. Even so, the terrific demands placed on aerial combatants in a Clausewitzian sense...Bomber Offensive. Subsequent chapters of the thesis deal directly with issues arising out of the extraordinarily demanding nature of air combat

c-Raf in KRas Mutant Cancers: A Moving Target.

PubMed

McCormick, Frank

2018-02-12

Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRas G12V /Trp53 tumors, without obvious systemic toxicity and without affecting MAPK signaling. Copyright © 2018 Elsevier Inc. All rights reserved.

Activated Raf-1 causes growth arrest in human small cell lung cancer cells.

PubMed Central

Ravi, R K; Weber, E; McMahon, M; Williams, J R; Baylin, S; Mal, A; Harter, M L; Dillehay, L E; Claudio, P P; Giordano, A; Nelkin, B D; Mabry, M

1998-01-01

Small cell lung cancer (SCLC) accounts for 25% of all lung cancers, and is almost uniformly fatal. Unlike other lung cancers, ras mutations have not been reported in SCLC, suggesting that activation of ras-associated signal transduction pathways such as the raf-MEK mitogen-activated protein kinases (MAPK) are associated with biological consequences that are unique from other cancers. The biological effects of raf activation in small cell lung cancer cells was determined by transfecting NCI-H209 or NCI-H510 SCLC cells with a gene encoding a fusion protein consisting of an oncogenic form of human Raf-1 and the hormone binding domain of the estrogen receptor (DeltaRaf-1:ER), which can be activated with estradiol. DeltaRaf-1:ER activation resulted in phosphorylation of MAPK. Activation of this pathway caused a dramatic loss of soft agar cloning ability, suppression of growth capacity, associated with cell accumulation in G1 and G2, and S phase depletion. Raf activation in these SCLC cells was accompanied by a marked induction of the cyclin-dependent kinase (cdk) inhibitor p27(kip1), and a decrease in cdk2 protein kinase activities. Each of these events can be inhibited by pretreatment with the MEK inhibitor PD098059. These data demonstrate that MAPK activation by DeltaRaf-1:ER can activate growth inhibitory pathways leading to cell cycle arrest. These data suggest that raf/MEK/ MAPK pathway activation, rather than inhibition, may be a therapeutic target in SCLC and other neuroendocrine tumors. PMID:9421477

United States Air Force Wipe Solvent Testing

NASA Technical Reports Server (NTRS)

Hornung, Steven D.; Beeson, Harold D.

2000-01-01

The Wright-Patterson Air Force Base (WPAFB), as part of the Air Force Material Command, requested that NASA Johnson Space Center (JSC) White Sands Test Facility (WSTF) conduct testing and analyses in support of the United States Air Force Wipe Solvent Development Project. The purpose of the wipe solvent project is to develop an alternative to be used by Air Force flight line and maintenance personnel for the wipe cleaning of oxygen equipment. This report provides material compatibility, liquid oxygen (LOX) mechanical impact, autogenous ignition temperature (AIT), and gauge cleaning test data for some of the currently available solvents that may be used to replace CFC-113 and methyl chloroform. It provides data from previous WSTF test programs sponsored by the Naval Sea Systems Command, the Kennedy Space Center, and other NASA programs for the purpose of assisting WP AFB in identifying the best alternative solvents for validation testing.

U.S. Air Force Doctrine: A Perspective

DTIC Science & Technology

1990-01-01

of Air Power." This document provided the independence long desired by proponents of a separate air force. It recognized the role of air superiority...guidance. First, AFM 1-1 fails to adequately address the corduct of war across the spectrum of conflict. The document tails to address the Vietnam war...have made it possible--in deed necessary-to update the doctrine;" "Air Force puts 3-2 in a class by itself and has given it superstar status billing

77 FR 55465 - US Air Force Exclusive Patent License

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-10

...: Air Force Research Laboratory Information Directorate, Rome, New York, Department of the Air Force.... Written objections should be sent to: Air Force Research Laboratory, Office of the Staff Judge Advocate, AFRL/RIJ, 26 Electronic Parkway, Rome, New York 13441-4514. Telephone: (315) 330-2087; Facsimile (315...

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

PubMed Central

Yamaguchi, Osamu; Watanabe, Tetsuya; Nishida, Kazuhiko; Kashiwase, Kazunori; Higuchi, Yoshiharu; Takeda, Toshihiro; Hikoso, Shungo; Hirotani, Shinichi; Asahi, Michio; Taniike, Masayuki; Nakai, Atsuko; Tsujimoto, Ikuko; Matsumura, Yasushi; Miyazaki, Jun-ichi; Chien, Kenneth R.; Matsuzawa, Atsushi; Sadamitsu, Chiharu; Ichijo, Hidenori; Baccarini, Manuela; Hori, Masatsugu; Otsu, Kinya

2004-01-01

The Raf/MEK/extracellular signal–regulated kinase (ERK) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and apoptosis and is implicated as an important contributor to the pathogenesis of cardiac hypertrophy and heart failure. To examine the in vivo role of Raf-1 in the heart, we generated cardiac muscle–specific Raf-1–knockout (Raf CKO) mice with Cre-loxP–mediated recombination. The mice demonstrated left ventricular systolic dysfunction and heart dilatation without cardiac hypertrophy or lethality. The Raf CKO mice showed a significant increase in the number of apoptotic cardiomyocytes. The expression level and activation of MEK1/2 or ERK showed no difference, but the kinase activity of apoptosis signal–regulating kinase 1 (ASK1), JNK, or p38 increased significantly compared with that in controls. The ablation of ASK1 rescued heart dysfunction and dilatation as well as cardiac fibrosis. These results indicate that Raf-1 promotes cardiomyocyte survival through a MEK/ERK–independent mechanism. PMID:15467832

Combat Squadrons of the Air Force, World War II,

DTIC Science & Technology

1982-01-01

1952. Inactivated on 1 Jul 1957. Redes- of a paddle wheel river boat, Air Force ignated 7o2d Troop Carrier Squadron blue, the windows lighted Air Force ...782d Bombard- hitched to a red wagon with wheels red, ment Squadron (Heavy) on 19 May hub yellow, tires and axles black, the 1943. Activated on 1 Aug...AD-A128 026 COMBAT SQUADRONS OF TOE AIR FORCE WORLD WAR IU) 1OFFICEOF AIR FORCE HISTORY WASHINGTON DC M MAURER UNCLASSIFIED F/G 15/7 NL

DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor.

PubMed

Kanno, Emiri; Kawasaki, Osamu; Takahashi, Kazuya; Takano, Kazunori; Endo, Takeshi

2018-01-01

Activating mutations of RAS genes, particularly KRAS, are detected with high frequency in human tumors. Mutated Ras proteins constitutively activate the ERK pathway (Raf-MEK-ERK phosphorylation cascade), leading to cellular transformation and tumorigenesis. DA-Raf1 (DA-Raf) is a splicing variant of A-Raf and contains the Ras-binding domain (RBD) but lacks the kinase domain. Accordingly, DA-Raf antagonizes the Ras-ERK pathway in a dominant-negative fashion and suppresses constitutively activated K-Ras-induced cellular transformation. Thus, we have addressed whether DA-Raf serves as a tumor suppressor of Ras-induced tumorigenesis. DA-Raf(R52Q), which is generated from a single nucleotide polymorphism (SNP) in the RBD, and DA-Raf(R52W), a mutant detected in a lung cancer, neither bound to active K-Ras nor interfered with the activation of the ERK pathway. They were incapable of suppressing activated K-Ras-induced cellular transformation and tumorigenesis in mice, in which K-Ras-transformed cells were transplanted. Furthermore, although DA-Raf was highly expressed in lung alveolar epithelial type 2 (AE2) cells, its expression was silenced in AE2-derived lung adenocarcinoma cell lines with oncogenic KRAS mutations. These results suggest that DA-Raf represents a tumor suppressor protein against Ras-induced tumorigenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

Air Force Strategy Study 2020-2030

DTIC Science & Technology

2011-01-01

shocks (also known as “black swans”), having 2 │ introduction the potential to radically alter the utility of the capability, as a way of highlighting... utilized by its expeditionary air units.”5 The Air Force must present strategic and operational options along with forces capable of operating and...Emer- gency Management Agency (FEMA) regional staffs, in part representing the service and USNORTHCOM. The imagery analysts’ utility is largely due

Advanced Robotics for Air Force Operations

DTIC Science & Technology

1989-06-01

evaluated current and potential uses of advanced robotics to support Air Force systems, (2) recommended the most effective aplications of advanced robotics...manpower. Such a robot system would The boom would not only transfer fuel, be considerably more mobile and effi- 10 ADVANCED ROBOTICS FOR AIR FORCE...increased manpower resources in war tive clothing reduce vision, hearing, and make this an attractive potential appli- mobility , which further reduce

The Air Force and the Cold War

DTIC Science & Technology

2005-09-01

March 2001. 49An Air Force Association Special Report 49An Air Force As ociation Special Report CANAN , James. War in Space. Harper & Row, 1982...Press, 1989. GARDNER, Lloyd C. Spheres of Influence: The Great Powers Partition Europe, From Munich to Yalta. Ivan R. Dee Publisher, 1993. GARTHOFF

Forecasting Foreign Currency Exchange Rates for Air Force Budgeting

DTIC Science & Technology

2015-03-26

FORECASTING FOREIGN CURRENCY EXCHANGE RATES FOR AIR FORCE BUDGETING THESIS MARCH 2015...States. AFIT-ENV-MS-15-M-178 FORECASTING FOREIGN CURRENCY EXCHANGE RATES FOR AIR FORCE BUDGETING THESIS Presented to the Faculty...FORECASTING FOREIGN CURRENCY EXCHANGE RATES FOR AIR FORCE BUDGETING Nicholas R. Gardner, BS Captain, USAF Committee Membership: Lt Col Jonathan

32 CFR 644.516 - Clearance of Air Force lands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Clearance of Air Force lands. 644.516 Section 644... Excess Land and Improvements § 644.516 Clearance of Air Force lands. The Chief of Engineers has no responsibility for inspecting or clearing excess Air Force land of explosives or chemical/biological contaminants...

Obstacles to the Termination of Air Force Activities.

DTIC Science & Technology

1986-04-01

sugsts how. it the Air Force leadership con- eludes that termination is necessary the Air Force can surmount the obstacles.’ The stud v was cMIduct ed...the Air Force leadership concludes that the termination of a major activity is a promising or necessary management option, the report suggests that it...complicated inter- nal political process; it takes time to work out. The top leadership should begin the process of corporate strategy building and priority

Nanoscience and Technology at the Air Force Research Laboratory (AFRL)

DTIC Science & Technology

2005-05-01

AIR FORCE RESEARCH LABORATORY ( AFRL ) Dr. Richard A. Vaia Dr. Daniel Miracle Dr. Thomas Cruse Air Force Research ...Technology At The Air Force Research Laboratory ( AFRL ) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...98) Prescribed by ANSI Std Z39-18 AFRL NST Overview 2 AIR FORCE RESEARCH LABORATORY VISION We defend

Nanoscience and Technology at the Air Force Research Laboratory (AFRL)

DTIC Science & Technology

2005-02-01

AIR FORCE RESEARCH LABORATORY ( AFRL ) Dr. Richard A. Vaia Dr. Daniel Miracle Dr. Thomas Cruse Air Force Research ...Technology At The Air Force Research Laboratory ( AFRL ) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...98) Prescribed by ANSI Std Z39-18 AFRL NST Overview 2 AIR FORCE RESEARCH LABORATORY VISION We defend

Analysis of Organizational Architectures for the Air Force Tuition Assistance Program

DTIC Science & Technology

2003-03-01

FORCE TUITION ASSISTANCE PROGRAM THESIS Krista Zimmerman LaPietra AFIT/GOR/ENS/03-15 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR...ANALYSIS OF ORGANIZATIONAL ARCHITECTURES FOR THE AIR FORCE TUITION ASSISTANCE PROGRAM THESIS Presented to the Faculty Department...ANALYSIS OF ORGANIZATIONAL ARCHITECTURES FOR THE AIR FORCE TUITION ASSISTANCE PROGRAM Krista Zimmerman LaPietra, BS

Design and synthesis of N-(4-aminopyridin-2-yl)amides as B-Raf(V600E) inhibitors.

PubMed

Li, Xiaokai; Shen, Jiayi; Tan, Li; Zhang, Zhang; Gao, Donglin; Luo, Jinfeng; Cheng, Huimin; Zhou, Xiaoping; Ma, Jie; Ding, Ke; Lu, Xiaoyun

2016-06-15

B-Raf(V600E) was an effective target for the treatment of human cancers. Based on a pan-Raf inhibitor TAK-632, a series of N-(4-aminopyridin-2-yl)amide derivatives were designed as novel B-Raf(V600E) inhibitors. Detailed structure-activity studies of the compounds revealed that most of the compounds displayed potent enzymatic activity against B-Raf(V600E), and good selectivity over B-Raf(WT). One of the most promising compound 4l exhibited potent inhibitory activity with an IC50 value of 38nM for B-raf(V600E), and displayed antiproliferative activities against colo205 and HT29 cells with IC50 values of 0.136 and 0.094μM, respectively. It also displayed good selectivity on both enzymatic and cellular assays over B-Raf(WT). These inhibitors may serve as lead compounds for further developing novel B-Raf(V600E) inhibitors as anticancer drugs. Copyright © 2016 Elsevier Ltd. All rights reserved.

Starfleet Deferred: Project Orion in the 1962 Air Force Space Program

NASA Astrophysics Data System (ADS)

Ziarnick, B.

Project Orion, the Cold War American program (1957-1965) studying nuclear pulse propulsion for space applications, has long interested space enthusiasts for what it was and what it might have been, but it has long been believed that neither the United States government nor the US Air Force took the program very seriously. However, recently declassified US Air Force documents shed more light on the classified history of Project Orion. Far from being ignored by Air Force leadership, through the efforts of the Strategic Air Command, Air Force leaders like General Curtis LeMay were convinced that Project Orion should be funded as a major weapons system. The high water mark of Project Orion was the 1962 Air Force Space Program proposal by the Air Force Chief of Staff to devote almost twenty percent of the Air Force space budget from 1962-1967 to Orion development before the program was cancelled by the civilian Secretary of the Air Force under pressure from the Department of Defense. This paper details the history of Project Orion in the 1962 Air Force Space Program proposal, and concludes with a few lessons learned for use by modern interstellar advocates.

Promoting Sound Ethical Decisions in the Air Force: CGO Solutions to Air Force Moral and Ethical Lapses

DTIC Science & Technology

2014-07-01

The second step is to create a Cross Check program—essentially franchising the Think Tank process in smaller groups across the Air Force as a forum...accessed 20 July 2014). 32  Cross Check Think Tank 14D proposes the implementation of “Cross Check” programs—essentially franchising the Think Tank...Tank Franchise , the meetings would be action-oriented, and networked together throughout the Air Force to provide lessons-learned, 33  resources

Improving Energy Security for Air Force Installations

NASA Astrophysics Data System (ADS)

Schill, David

Like civilian infrastructure, Air Force installations are dependent on electrical energy for daily operations. Energy shortages translate to decreased productivity, higher costs, and increased health risks. But for the United States military, energy shortages have the potential to become national security risks. Over ninety-five percent of the electrical energy used by the Air Force is supplied by the domestic grid, which is susceptible to shortages and disruptions. Many Air Force operations require a continuous source of energy, and while the Air Force has historically established redundant supplies of electrical energy, these back-ups are designed for short-term outages and may not provide sufficient supply for a longer, sustained power outage. Furthermore, it is the goal of the Department of Defense to produce or procure 25 percent of its facility energy from renewable sources by fiscal year 2025. In a government budget environment where decision makers are required to provide more capability with less money, it is becoming increasingly important for informed decisions regarding which energy supply options bear the most benefit for an installation. The analysis begins by exploring the field of energy supply options available to an Air Force installation. The supply options are assessed according to their ability to provide continuous and reliable energy, their applicability to unique requirements of Air Force installations, and their costs. Various methods of calculating energy usage by an installation are also addressed. The next step of this research develops a methodology and tool which assesses how an installation responds to various power outage scenarios. Lastly, various energy supply options are applied to the tool, and the results are reported in terms of cost and loss of installation capability. This approach will allow installation commanders and energy managers the ability to evaluate the cost and effectiveness of various energy investment options.

Heterogeneous nuclear ribonucleoprotein H Blocks MST2-Dependent Apoptosis in Cancer Cells via Regulation of A-Raf transcription

PubMed Central

Rauch, Jens; O'Neill, Eric; Mack, Brigitte; Matthias, Christoph; Munz, Markus; Kolch, Walter; Gires, Olivier

2010-01-01

Summary A-Raf belongs to the family of oncogenic Raf kinases that are involved in mitogenic signalling by activating the MEK-ERK pathway. Low kinase activity of A-Raf towards MEK suggested that A-Raf might have alternative functions. We show that A-Raf prevents cancer cell apoptosis contingent on the expression of the hnRNP H splice factor, which is required for the correct transcription and expression of A-Raf. A-Raf prevented apoptosis by sequestering and inactivating the pro-apoptotic MST2 kinase. Knock-down of hnRNP H or A-Raf resulted in MST2-dependent apoptosis, while enforced expression of either one partially counteracted apoptosis induced by etoposide. In vivo expression studies in colon specimens corroborated the over-expression of hnRNP H in malignant tissues and its correlation with A-Raf levels. In summary, we present a novel route that is usurped by tumor cells to escape naturally imposed apoptotic signals. PMID:20145135

Low-temperature forced-air drying of Appalachian hardwoods

Treesearch

Donald G. Cuppett; E. Paul Craft

1975-01-01

Low-temperature forced-air drying involves drying green lumber in heated buildings with forced-air circulation and partial control of temperature and humidity conditions. The lumber is dried to about 20 percent moisture content at dry-bulb temperatures of 70º to 110ºF and with air velocities of 300 to 600 feet per minute. Equipment, methods, and...

Air Force construction automation/robotics

NASA Technical Reports Server (NTRS)

Nease, AL; Dusseault, Christopher

1994-01-01

The Air Force has several unique requirements that are being met through the development of construction robotic technology. The missions associated with these requirements place construction/repair equipment operators in potentially harmful situations. Additionally, force reductions require that human resources be leveraged to the maximum extent possible and that more stringent construction repair requirements push for increased automation. To solve these problems, the U.S. Air Force is undertaking a research and development effort at Tyndall AFB, FL to develop robotic teleoperation, telerobotics, robotic vehicle communications, automated damage assessment, vehicle navigation, mission/vehicle task control architecture, and associated computing environment. The ultimate goal is the fielding of robotic repair capability operating at the level of supervised autonomy. The authors of this paper will discuss current and planned efforts in construction/repair, explosive ordnance disposal, hazardous waste cleanup, fire fighting, and space construction.

75 FR 32750 - US Air Force Scientific Advisory Board Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-09

... DEPARTMENT OF DEFENSE Department of the Air Force US Air Force Scientific Advisory Board Notice of Meeting AGENCY: Department of the Air Force, US Air Force Scientific Advisory Board. ACTION: Meeting....150, the Department of Defense announces that the United States Air Force Scientific Advisory Board...

International Affairs Programs: The Air Force Versus the Army

DTIC Science & Technology

2015-10-01

individual tutoring programs . Additionally RAS personnel are offered regional enhancement studies opportunities at several facilities.48 RAS personnel...AU/ACSC/2015 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY INTERNATIONAL AFFAIRS PROGRAMS : THE AIR FORCE VERSUS THE ARMY by Robin L...5 COMPARISON: INTERNATIONAL AFFAIRS PROGRAMS AIR FORCE VERSUS ARMY 8

United States Air Force Summer Research Program -- 1993. Volume 3. Phillips Laboratory

DTIC Science & Technology

1993-12-01

PHILLIPS LABORATORY KIRTLAND AIR FORCE BASE, NEW MEXICO SPONSORED BY: AIR FORCE OFFICE OF SCIENTIFIC RESEARCH ROLLING AIR FORCE BASE, WASHINGTON ,D.C...Report for. Summer Faculty Research Program at Phillips Laboratory Kirtland Air Force Base Sponsored by: Air Force Offlce of Scientific Research ...Prcgram Phillips Laboratory Kirtland

The Value of an Independent Royal Air Force - Breaking the Oscar Wilde Paradigm in British Defence

DTIC Science & Technology

2010-06-01

discussion. 11 Ian Drury , Defence Correspondent, "Could this be the end for the RAF? Military chief refuses to rule out merger with Navy as cuts loom...However, would it provide the flexibility to be effective if a different threat emerged in ten years time? In contrast to Smith‟s thesis, Colin ...1984), 88. 25 General Rupert Smith, The Utility of Force – The Art of War in the Modern World (New York, NY: Vintage Books, 2008), 5. 26 Colin

Environmental Assessment Proposed Demolition Plan Hill Air Force Base, Utah

DTIC Science & Technology

2010-04-01

1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law , no person shall be subject to a penalty...Demolition Plan Hill Air Force Base, Utah 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK...NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) United States Air Force - Air Force Material Command,Hill Air Force

Challenges of Enterprise Wide AM for Air Force Sustainment

DTIC Science & Technology

2016-12-01

December 2016 Naguy is chief of the Air Force Life Cycle Management Center’s Product Support Engineering Division at Wright Patterson Air Force Base in...today and into the future. To truly capitalize on the full potential of AM, the Air Force Life Cycle Management Center (AFLCMC) in close collabora...approach for material standards and quality include un- derstanding powder characteristics, developing an enterprise material characterization

Inspector General, DOD, Oversight of the Air Force Audit Agency Audit of the FY 1999 Air Force General Fund Financial Statements

DTIC Science & Technology

2000-02-14

Consolidated Financial Statements . Our objective was to determine the accuracy and completeness of the Air Force Audit Agency audit of the FY 1999 Air Force General Fund financial statements. See Appendix A for a discussion of the audit

ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE

PubMed Central

McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Abrams, Steven L.; Wong, Ellis WT.; Chang, Fumin; Lehmann, Brian; Terrian, David M.; Milella, Michele; Tafuri, Agostino; Stivala, Franca; Libra, Massimo; Basecke, Jorg; Evangelisti, Camilla; Martelli, Alberto M.; Franklin, Richard A.

2009-01-01

Summary Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly expressed in human cancer (e.g., Ras, B-Raf). Mutations also occur at genes encoding upstream receptors (e.g., EGFR and Flt-3) and chimeric chromosomal translocations (e.g., BCR-ABL) which transmit their signals through these cascades. Even in the absence of obvious genetic mutations, this pathway has been reported to be activated in over 50% of acute myelogenous leukemia and acute lymphocytic leukemia and is also frequently activated in other cancer types (e.g., breast and prostate cancers). Importantly, this increased expression is associated with a poor prognosis. The Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways interact with each other to regulate growth and in some cases tumorigenesis. For example, in some cells, PTEN mutation may contribute to suppression of the Raf/MEK/ERK cascade due to the ability of activated Akt to phosphorylate and inactivate different Rafs. Although both of these pathways are commonly thought to have anti-apoptotic and drug resistance effects on cells, they display different cell lineage specific effects. For example, Raf/MEK/ERK is usually associated with proliferation and drug resistance of hematopoietic cells, while activation of the Raf/MEK/ERK cascade is suppressed in some prostate cancer cell lines which have mutations at PTEN and express high levels of activated Akt. Furthermore the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways also interact with the p53 pathway. Some of these interactions can result in controlling the activity and subcellular localization of Bim, Bak, Bax, Puma and Noxa. Raf/MEK/ERK may promote cell cycle arrest in prostate cells and this may be regulated by p53 as restoration of wild-type p53 in p53 deficient prostate cancer cells results in their enhanced sensitivity to

Embouchure Dysfunction in Air Force Band Brass Musicians.

PubMed

Storms, Patrick R; Elkins, Candice P; Strohecker, Eric M

2016-06-01

Occupational injuries and medical problems in musicians are well described, but relatively less attention has been paid to orofacial and embouchure-related problems in professional brass players. This study addressed embouchure-related problems in Air Force Band members, a population of musicians with an intense practice and performance schedule. A survey was developed and distributed via the Air Force Survey Office to 599 active-duty Air Force Band members and 201 Air National Guard members. The survey assessed practice patterns, practice and performance venues, and presence of symptoms suggesting embouchure dysfunction. Responses were obtained from 167 Air Force Band brass players. Of the 157 responding to the question about embouchure dysfunction, 42% reported having experienced an embouchure problem at some point in the past, and 53% of those respondents reported that they were currently experiencing an embouchure problem. Forty-one percent of those with embouchure problems cited practice venues that were not conducive to effective and efficient practice at the time their embouchure problems began, and 48% of those with embouchure problems reported having to overblow in rehearsal at the time their problems began. Embouchure disorders were reported in a large proportion of Air Force Band brass survey respondents, and specific concerns related to practice venues and the need to overblow in practice settings suggest factors suitable to remediation and preventive strategies.

Neonatal pulmonary arterial hypertension and Noonan syndrome: two fatal cases with a specific RAF1 mutation.

PubMed

Hopper, Rachel K; Feinstein, Jeffrey A; Manning, Melanie A; Benitz, William; Hudgins, Louanne

2015-04-01

Mutations in RAF1 are associated with Noonan syndrome and hypertrophic cardiomyopathy. We present two infants with Noonan syndrome and an identical RAF1 mutation, p.Ser257Leu (c.770C>T), who developed severe pulmonary arterial hypertension (PAH) that proved to be fatal. The RAF1 gene encodes Raf-1 kinase, part of the Ras/mitogen-activated kinase (MAPK) signaling pathway, which has been linked to the development of PAH. This specific mutation has been associated with dephosphorylation of a critical serine residue and constitutive activation of the Raf-1 kinase. These two cases suggest that abnormal activation of the Ras/MAPK pathway may play a significant role in the development of pulmonary vascular disease in the subset of patients with Noonan syndrome and a specific RAF1 mutation. © 2015 Wiley Periodicals, Inc.

Science and Technology: The Making of the Air Force Research Laboratory

DTIC Science & Technology

2000-01-01

AFRL . . . . . . . . . . . 187 11 Air Force Research Laboratory : Before and After...United States Air Force during my tenure as chief of staff—the crea - tion of the Air Force Research Laboratory ( AFRL ). As the “high technology” service...consolidate four existing laboratories into one Air Force Research Laboratory ( AFRL ) designed to lead to a more efficient and streamlined

U.S. Air Force Annual Financial Statement 2010

DTIC Science & Technology

2010-01-01

certain contract financing payments that are not reported elsewhere on Air Force’s Balance Sheet. The Air Force conducts business with commercial...the reporting entity has a contractual commitment for payment is $712.8 million. The Air Force is a party in numerous individual contracts that...promulgated by the Federal Accounting Standards Advisory Board; the Office of Management and Budget (OMB) Circular No. A-136, Financial Reporting

The Roots of the Command and Control of Air Power: An Appraisal of Three Air Forces Through 1945

DTIC Science & Technology

2014-09-17

Co., 1927), 121. 33 Joubert de la Ferté, The Third Service, 48. 34 Scot Robertson, The Development of RAF Strategic Bombing Doctrine, 1919-1939...5 Scot Robertson, The Development of RAF Strategic Bombing Doctrine, 1919-1939 (Westport, Conn: Praeger, 1995), 36. 6 Powers, Strategy without...Royal United Services Institution Vol LXXV (February 1930): 109. 36 Collier, The Defence of the United Kingdom, 12.; Derek Wood and Derek D. Dempster

Army and Air Force Unmanned Air Reconnaissance: Warrior and Hydra Navigating a Maze of Strategic Hedges

DTIC Science & Technology

2009-06-01

Chambliss; Colonel Michael Stickney; Colonel Eric Mathewson; Lieutenant Colonel Robert Kiebler; Lieutenant Colonel Kenneth Kilmurray; Lieutenant...16 Peter Layton , Group Captain, Royal Air Force, “Hedging Strategies, UCAVs, budgets, and improbable threats,” Armed Forces Journal...10 Colonel Eric Mathewson, US Air Force HAF/A2 DCS ISR, “Air Force ISR in a Changed World: ISR Transformation, the Importance

United States Air Force Summer Research Program -- 1993. Volume 13. Phillips Laboratory

DTIC Science & Technology

1993-12-01

Research Kirtland Air Force Base, Albuquerque, NM August 1993 14-1 My Summer Apprenticeship At Kirtland Air Force Base, Phillips Laboratory Andrea Garcia...AFOSR Summer Research Program Phillips Laboratory Sponsored By: Air Force Office of Scientific Research Kirtland Air Force Base, Albuquerque, NM... Phillips Laboratory Sponsored by: Air

Evaluation of Air Force and Navy Demand Forecasting Systems

DTIC Science & Technology

1994-01-01

forecasting approach, the Air Force Material Command is questioning the adoption of the Navy’s Statistical Demand Forecasting System ( Gitman , 1994). The...Recoverable Item Process in the Requirements Data Bank System is to manage reparable spare parts ( Gitman , 1994). Although RDB will have the capability of...D062) ( Gitman , 1994). Since a comparison is made to address Air Force concerns, this research only limits its analysis to the range of Air Force

U.S. Air Force Environmental Assessment, Steam Decentralization Project, Tinker Air Force Base, Oklahoma

DTIC Science & Technology

2011-08-01

Estimated Air Pollutant Emissions for Boilers at CSPs at Tinker AFB ..................... 3-8 6 Table 3-2. Special Status Plant and Animal Species of...environment associated with the decentralization and optimization offour central steam plants (CSPs) located at Tinker Air Force Base (AFB), Oklahoma...square feet and represent approximately 48 percent of the installation’s total building area. Three of the plants (CSP 208, CSP 3001 and CSP 5802

Surgically Shaping a Financial Hydra: Reprogramming United States Air Force End Strength to the Air Reserve Component

DTIC Science & Technology

2012-02-14

Director of the Air National Guard20 Lt Gen Charles E. Stenner Jr., Chief of the Air Force Reserve21 Specificity about what rebalancing the force...January 2012). Sharp, Travis. Vision Meets Reality: 2010 QDR and 2011 Defense Budget. Center for a New American Security, February 2010. Stenner ...Lt Gen Charles E. Stenner Jr., commander of Air Force Reserve Command (address, Air Force Reserve Senior Leader Conference

Raf-1 levels determine the migration rate of primary endometrial stromal cells of patients with endometriosis

PubMed Central

Yotova, Iveta; Quan, Ping; Gaba, Aulona; Leditznig, Nadja; Pateisky, Petra; Kurz, Christine; Tschugguel, Walter

2012-01-01

Endometriosis is a disease characterized by the localization of endometrial tissue outside the uterine cavity. The differences observed in migration of human endometrial stromal cells (hESC) obtained from patients with endometriosis versus healthy controls were proposed to correlate with the abnormal activation of Raf-1/ROCKII signalling pathway. To evaluate the mechanism by which Raf-1 regulates cytoskeleton reorganization and motility, we used primary eutopic (Eu-, n = 16) and ectopic (Ec-, n = 8; isolated from ovarian cysts) hESC of patients with endometriosis and endometriosis-free controls (Co-hESC, n = 14). Raf-1 siRNA knockdown in Co- and Eu-hESC resulted in contraction and decreased migration versus siRNA controls. This phenotype was reversed following the re-expression of Raf-1 in these cells. Lowest Raf-1 levels in Ec-hESC were associated with hyperactivated ROCKII and ezrin/radixin/moesin (E/R/M), impaired migration and a contracted phenotype similar to Raf-1 knockdown in Co- and Eu-hESC. We further show that the mechanism by which Raf-1 mediates migration in hESC includes direct myosin light chain phosphatase (MYPT1) phosphorylation and regulation of the levels of E/R/M, paxillin, MYPT1 and myosin light chain (MLC) phosphorylation indirectly via the hyperactivation of ROCKII kinase. Furthermore, we suggest that in contrast to Co-and Eu-hESC, where the cellular Raf-1 levels regulate the rate of migration, the low cellular Raf-1 content in Ec-hESC, might ensure their restricted migration by preserving the contracted cellular phenotype. In conclusion, our findings suggest that cellular levels of Raf-1 adjust the threshold of hESC migration in endometriosis. PMID:22225925

Air Force Leadership Development: Transformation’s Constant

DTIC Science & Technology

2003-05-01

AU/SCHOOL/NNN/2001-04 DEPARTMENT OF STATE SENIOR SEMINAR NATIONAL FOREIGN AFFAIRS TRAINING CENTER AIR FORCE LEADERSHIP DEVELOPMENT...valid OMB control number. 1. REPORT DATE MAY 2003 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Air Force Leadership ...6 THE LEADERSHIP ESSENTIALS

Environmental Assessment: Military Family Housing Privatization Maxwell Air Force Base

DTIC Science & Technology

2005-06-01

Ray L. Raton Mildred J . Worthy February 9, 2005 Lt. Colonel David W. Maninez Deputy Commander, 42nd MSG 50 South LeMay Plaza (Bldg 804) Maxwell ...Environmental Assessment Military Family Housing Privatization Maxwell Air Force Base United States Air Force Air Education and Training Command... Maxwell Air Force Base, Alabama June 2005 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of

32 CFR 644.327 - Air Force military real property.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Air Force military real property. 644.327 Section... Force military real property. Military real property under the control of the Department of the Air Force will be placed in excess status as outlined in AFR 87-4. ...

32 CFR 806.29 - Administrative processing of Air Force FOIA requests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... section. (c) Contacts with FOIA requesters and non-Air Force submitters of data. (1) Contacts with Air... memoranda documenting requester contacts with Air Force elements regarding a pending FOIA request in the requester's FOIA file. If the requester contacts Air Force elements telephonically about a pending FOIA...

32 CFR 806.29 - Administrative processing of Air Force FOIA requests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... section. (c) Contacts with FOIA requesters and non-Air Force submitters of data. (1) Contacts with Air... memoranda documenting requester contacts with Air Force elements regarding a pending FOIA request in the requester's FOIA file. If the requester contacts Air Force elements telephonically about a pending FOIA...

32 CFR 806.29 - Administrative processing of Air Force FOIA requests.

Code of Federal Regulations, 2014 CFR

2014-07-01

... section. (c) Contacts with FOIA requesters and non-Air Force submitters of data. (1) Contacts with Air... memoranda documenting requester contacts with Air Force elements regarding a pending FOIA request in the requester's FOIA file. If the requester contacts Air Force elements telephonically about a pending FOIA...

Imaging of Ras/Raf activity induced by low energy laser irradiation in living cell using FRET

NASA Astrophysics Data System (ADS)

Wang, Fang; Chen, Tong-Sheng; Xing, Da

2005-01-01

Ras/Raf signaling pathway is an important signaling pathway that governs cell proliferation, differential and apoptosis. Low-energy laser irradiation (LELI) was found to modulate various processes. Generally, cell proliferation is induced by low doses LELI and apoptosis is induced by high doses LELI. Mechanism of biological effect of LELI has not been clear. Recently, activation of MEK (mitogen-activated protein kinase) and ERK (extracellular-signal-regulated kinase), which are downstream protein kinases of Ras/Raf, are observed during LELI-induced cell proliferation by immunoprecipitation and western blot analysis. RaichuRas reporter consisting of fusions of H-ras, the Ras-binding domain of Raf (RafRBD), a cyan fluorescent protein (CFP) and a yellow fluorescent protein (YFP). Therefore, intramolecular binding of GTP-Ras to RafRBD brings CFP close to YFP and increases FRET between CFP and YFP. Human lung adenocarcinoma cell line (ASTC-a-1) was transfected with the plasmid (pRaichuRas) and then treated with LELI at dose of 60J/cm2. Effect of LELI on Ras/Raf in physiological condition of living cells was observed by fluorescence resonance energy transfer (FRET) technique during lung adenocarcinoma cell apoptosis induced by high dose (60J/cm2) LELI. Experimental results showed that after high dose LELI treatment, the binding of Ras and Raf decreases obviously, Ras/Raf signaling pathway deregulates and cell apoptosis occurs.

Absenteeism Among Air Force Active Duty and Civilian Personnel.

DTIC Science & Technology

1985-09-01

Fitzgibbons, Dale and Michael Moch. "Employee Absenteeism : A Multivariate Analysis with Replication," Organizational Behavior and Human Performance ...AD-A161 073 ABSENTEEISM AMONG AIR FORCE ACTIVE DUTY AND CIVILIAN PERSONNEL(U) AIR FORCE INST OF TECH IRIGHT-PRTTERSON AFB OH SCHOOL OF SYSTEMS AND...8217o 7 ABSENTEEISM AMONG AIR FORCE ACTIUE DUTY AND CIUILIAN PERSONNEL THESIS William M. Getter Captain, USAF AF IT/GLM/LSB/5S-27 DT|C ELECTE SNOVI 2Q8 v

SOUTHEAST AND NORTHEAST SIDES. Looking west Edwards Air Force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHEAST AND NORTHEAST SIDES. Looking west - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Fuel & Water Tank, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

B-Raf kinase inhibitors: hit enrichment through scaffold hopping.

PubMed

Gopalsamy, Ariamala; Shi, Mengxiao; Hu, Yongbo; Lee, Frederick; Feldberg, Larry; Frommer, Eileen; Kim, Steven; Collins, Karen; Wojciechowicz, Donald; Mallon, Robert

2010-04-15

In continuation of our efforts toward hit identification and optimization for a B-Raf kinase project, we have employed a scaffold hopping strategy. The original HTS hit scaffold pyrazolo[1,5-a]pyrimidine was replaced with different thienopyrimidine and thienopyridine scaffolds to append the optimal pharmacophore moieties in order to generate novel B-raf kinase inhibitors with desirable potency and properties. This strategy led to the identification of additional lead compound 11b which had good enzyme and cell potency, while maintaining selectivity over a number of kinases. Copyright 2010 Elsevier Ltd. All rights reserved.

2. GENERAL VIEW OF SLC3 AIR FORCE BUILDING (BLDG. 761) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. GENERAL VIEW OF SLC-3 AIR FORCE BUILDING (BLDG. 761) FROM THE NORTHWEST - Vandenberg Air Force Base, Space Launch Complex 3, SLC-3 Air Force Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

1. GENERAL VIEW OF SLC3 AIR FORCE BUILDING (BLDG. 761) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF SLC-3 AIR FORCE BUILDING (BLDG. 761) FROM THE SOUTHWEST - Vandenberg Air Force Base, Space Launch Complex 3, SLC-3 Air Force Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Hazardous waste: Siting of storage facility at Kelly Air Force Base, Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-01-01

This report provides information on whether the hazardous waste storage facility at Kelly Air Force Base meets Resource Conservation and Recovery Act, state, and Air Force siting requirements; on whether the Air Force or the Defense Reutilization and Marketing Office selected the best site available to protect the public and to preserve good public relations with the community; on whether the Air Force, Kelly Air Force Base, or the Defense Logistics Agency adjusted siting standards as a result of the adverse publicity the hazardous waste facility has generated; and on whether Kelly Air Force Base is revising its hazardous wastemore » management organization so that it is similar to the organizations at Tinker and McClellan Air Force Bases.« less

Air Force Research Laboratory Sensors Directorate Leadership Legacy, 1960-2011

DTIC Science & Technology

2011-03-01

AFRL -RY-WP-TM-2011-1017 AIR FORCE RESEARCH LABORATORY SENSORS DIRECTORATE LEADERSHIP LEGACY, 1960-2011 Compiled by Raymond C. Rang...Structures Divi- sion, Space Vehicles Directorate, Air Force Research Laboratory , Kirtland AFB, N.M. 7. March 1998 - July 1999, Chief, Integration and... Research Laboratory ( AFRL ), and Deputy Director of the Sensors Direc- torate, Air Force Research

10. "TEST STAND 15, AIR FORCE FLIGHT TEST CENTER." ca. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. "TEST STAND 1-5, AIR FORCE FLIGHT TEST CENTER." ca. 1958. Test Area 1-115. Original is a color print, showing Test Stand 1-5 from below, also showing the superstructure of TS1-4 at left. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

Trauma risk management (TRiM) in the UK Armed Forces.

PubMed

Greenberg, N; Langston, V; Jones, N

2008-06-01

Trauma Risk Management (TRiM) is a novel system of post incident management which intend to allow commanders to provide appropriate support to their subordinates in the aftermath of traumatic events. Given the current very considerable operational tempo being experienced by the majority of the UK Armed Forces, it is perhaps not surprising that TRiM has been in use in both Iraq and Afghanistan. Although TRiM originated from within the Royal Marines, it is now widely used in both the Royal Navy and Army; there are also plans to introduce it into specific components of the Royal Air Force such as for the RAF Regiment. This paper aims to explore the basis behind the TRiM system and to explore the evidence for its growing popularity within hierarchical organisations such as the military.

76 FR 18537 - U.S. Air Force Scientific Advisory Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... DEPARTMENT OF DEFENSE Department of the Air Force U.S. Air Force Scientific Advisory Board; Notice of Meeting AGENCY: Department of the Air Force, US Air Force Scientific Advisory Board. ACTION... 102-3.150, the Department of Defense announces that the United States Air Force Scientific Advisory...

The United States Air Force in Korea: A Chronology, 1950-1953

DTIC Science & Technology

2000-01-01

War , the U.S. Air Force (USAF) Historian commissioned the Research Division, Air Force His- torical Research Agency (AFHRA), Maxwell Air Force Base...and aces. Finally, it attempts to summarize those USAF events in Korea that best illustrate the air war and the application of air power in the...sources, usually to confirm the most signifi- cant events of the air war in Korea. AFHRA historians or archivists who researched and wrote the monthly and

Forced convection heat transfer to air/water vapor mixtures

NASA Technical Reports Server (NTRS)

Richards, D. R.; Florschuetz, L. W.

1984-01-01

Heat transfer coefficients were measured using both dry and humid air in the same forced convection cooling scheme and were compared using appropriate nondimensional parameters (Nusselt, Prandtl and Reynolds numbers). A forced convection scheme with a complex flow field, two dimensional arrays of circular jets with crossflow, was utilized with humidity ratios (mass ratio of water vapor to air) up to 0.23. The dynamic viscosity, thermal conductivity and specific heat of air, steam and air/steam mixtures are examined. Methods for determining gaseous mixture properties from the properties of their pure components are reviewed as well as methods for determining these properties with good confidence. The need for more experimentally determined property data for humid air is discussed. It is concluded that dimensionless forms of forced convection heat transfer data and empirical correlations based on measurements with dry air may be applied to conditions involving humid air with the same confidence as for the dry air case itself, provided that the thermophysical properties of the humid air mixtures are known with the same confidence as their dry air counterparts.

76 FR 65187 - U.S. Air Force Scientific Advisory Board Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-20

... DEPARTMENT OF DEFENSE Department of the Air Force U.S. Air Force Scientific Advisory Board Notice of Meeting AGENCY: US Air Force Scientific Advisory Board, Department of the Air Force, DoD. ACTION: Meeting Cancellation Notice. SUMMARY: Due to difficulties, beyond the control of the U.S. Air Force...

Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries.

PubMed

Sathishkumar, Kunju; Yallampalli, Uma; Elkins, Rebekah; Yallampalli, Chandra

2010-01-01

We investigated the potential role of Raf-1 kinase in mesenteric arterial contraction. Inhibitors of Raf-1 kinase, GW5074, L779450 and ZM 336372 reversed phenylephrine (PE)-induced mesenteric vascular contraction. Studies in vivo in rats showed that GW5074 inhibited PE-induced increase in mean arterial pressure in adult female Sprague-Dawley rats. Isometric tension studies in mesenteric arteries of rats showed that GW5074 did not change the KCl-evoked contraction but significantly inhibited the contractions to PE, 5-HT, U46619, endothelin 1, angiotensin II and phorbol 12, 13-dibutyrate (PDBu). In mesenteric vascular smooth muscle cells (VSMCs), PE stimulated increase in Raf-1 phosphorylation which was inhibited by GW5074. Measurement of [Ca(2+)](i) with Fura-2 showed that GW5074-mediated inhibition of PE-induced contraction was not associated with decreases in [Ca(2+)](i). VSMCs treated with PE exhibited higher levels of the contractile proteins, p-MYPT1 and p-MLC(20), which was inhibited by GW5074. Similarly, PDBu induced increases in phosphorylation of Raf-1, MLC(20) and MYPT1 and this was inhibited by GW5074. However, GW5074 did not have any significant effect on PE/PDBu-induced MEK/ERK activation. The results indicate that Raf-1 kinase plays an important role in the regulation of vascular contractility through regulation of calcium sensitization.

Air Force Journal of Logistics. Volume 29, Number 1, Spring 2005

DTIC Science & Technology

2005-01-01

Air Force, is necessary in the transaction of the public business as required by the law of the department. The Secretary of the Air Force approved the...reengineer Air Force Materiel Command (AFMC) progress and introduce a supplier scorecard. sustainment business processes. This transformation effort, AFMC...empowerment." company. I think one of the things we’re seeing in American However, the business side of the Air Force consistently has business is a resurgence

4. BUILDING 8767, INTERIOR. Looking west. Edwards Air Force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. BUILDING 8767, INTERIOR. Looking west. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunkers for Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

Fixing the Mobility Air Forces New Way

DTIC Science & Technology

2013-03-01

Stenner explains, “Our units and people make outstanding contributions to the national defense. Every day, we leverage a portion of the strategic...calculate the ARC’s contribution to the military’s global reach.78 The cost effectiveness that General Stenner refers to is only one of at least three...Department of the Air Force, Mobilization Planning, 18. 60 Ibid. 61 U.S. Department of the Air Force, Mobilization Planning, 9. 62 Charles E. Stenner

76 FR 28215 - U.S. Air Force Scientific Advisory Board Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-16

... DEPARTMENT OF DEFENSE Department of the Air Force U.S. Air Force Scientific Advisory Board Notice of Meeting AGENCY: Department of the Air Force, U.S. Air Force Scientific Advisory Board, DoD. ACTION... 102-3.150, the Department of Defense announces that the United States Air Force Scientific Advisory...

Air Force Officer Specialty Structure. Reviewing the Fundamentals

DTIC Science & Technology

2009-01-01

Corporation, is the U.S. Air Force’s federally funded research and development center for studies and analyses. PAF pro - vides the Air Force with...Shirlene LeBleu for sharing their database and insights about job con - tent and specialty analyses. At the Air Force Manpower Agency, we thank Col...processes. Also, we thank Maj Ernest Wearren (AF/ A1MZ) and Gary Stockinger (AF/A1MX) for sharing their knowledge of the Manpower Pro - gramming Execution

Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Volume 1

DTIC Science & Technology

1991-03-01

found to be significantly associated with coordination and a central nervous system index, but cranial nerve function and peripheral nerve status...AD-A237 516 Air Force Health Study A An Epidemiologic In vestigation of Health Effects in Air Force Personnel Following Exposure to Herbicides SAIC...Smeda SCIENCE APPLICATIONS EPIDEMIOLOGY RESEARCH DIVISION INTERNATIONAL CORPORATION ARMSTRONG LABORATORY 8400 Westpark Drive HUMAN SYSTEMS DIVISION

77 FR 22770 - U.S. Air Force Scientific Advisory Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... extended use of Air Force Space Command space-based sensors. In accordance with 5 U.S.C. 552b, as amended... DEPARTMENT OF DEFENSE Department of the Air Force U.S. Air Force Scientific Advisory Board; Notice of Meeting AGENCY: Department of the Air Force, U.S. Air Force Scientific Advisory Board. ACTION...

United States Air Force Graduate Student Research Program. 1989 Program Management Report

DTIC Science & Technology

1989-12-01

research at Air Force laboratories /centers. Each assignment is in a subject area and at an Air Force facility mutually agreed upon by the...housing difficult to find, c) 10 weeks too short for research period. June 20, 1989 Astronautics Laboratory Edwards Air Force Base, California June 21...1989 HRL: Operations Training Division Williams Air Force Base, Arizona June 22, 1989 Weapons Laboratory Kirtland Air

Mindfulness over matter > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Report on Operations of the Air Force Geophysics Laboratory Infrared Array Spectrometer

DTIC Science & Technology

1993-01-25

AIR FORCE GEOPHYSICS LABORATORY INFRARED ARRAY... LABORATORY Directorate of Geophysics AIR FORCE MATERIEL COMMAND HANSCOM AIR FORCE BASE, MA 01731-3010 93-27655IEEE|EIIE1ENI This technical report has...ACKNOWLEDGMENT We are grateful to the Air Force Office of Scientific Research , especially Henry Radowski. for their financial corn- mitment to this project.

The Official Home Page of the U.S. Air Force

Science.gov Websites

: May 24 Air Force directs one-day operational safety review SecAF LOI SecAF LOI Letter of Intent AF and members using two C-130 and one C-17 training airframes. (U.S. Air Force photo by Richard Eldridge) The Transport Team crew members using two C-130 and one C-17 training airframes. (U.S. Air Force photo by

Air Force construction automation/robotics

NASA Technical Reports Server (NTRS)

Nease, A. D.; Alexander, E. F.

1993-01-01

The Air Force has several missions which generate unique requirements that are being met through the development of construction robotic technology. One especially important mission will be the conduct of Department of Defense (DOD) space activities. Space operations and other missions place construction/repair equipment operators in dangerous environments and potentially harmful situations. Additionally, force reductions require that human resources be leveraged to the maximum extent possible, and more stringent construction repair requirements push for increased automation. To solve these problems, the U.S. Air Force is undertaking a research and development effort at Tyndall AFB, FL, to develop robotic construction/repair equipment. This development effort involves the following technologies: teleoperation, telerobotics, construction operations (excavation, grading, leveling, tool change), robotic vehicle communications, vehicle navigation, mission/vehicle task control architecture, and associated computing environment. The ultimate goal is the fielding of a robotic repair capability operating at the level of supervised autonomy. This paper will discuss current and planned efforts in space construction/repair, explosive ordnance disposal, hazardous waste cleanup, and fire fighting.

77 FR 5781 - Record of Decision for the Air Space Training Initiative Shaw Air Force Base, South Carolina...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... DEPARTMENT OF DEFENSE Department of the Air Force Record of Decision for the Air Space Training Initiative Shaw Air Force Base, South Carolina Final Environmental Impact Statement ACTION: Notice of Availability (NOA) of a Record of Decision (ROD). SUMMARY: On December 9, 2011, the United States Air Force...

Creating Joint Leaders Today for a Successful Air Force Tomorrow (1REV)

DTIC Science & Technology

2016-04-01

armed force in the same grade and competitive category who are serving on, or have served on, the HQ staff of their armed force; and 2. Officers in the...period from the release of the promotion results and the pin-on date. 5 Department of the Air Force, HQ Air Force Personnel Center, Demographics and...2009), Section 619a. 9 ibid, Section 619a. 10 Department of the Air Force, HQ Air Force Personnel Center, A-1 Manpower Division. 11 Phone

The United States Air Force Academy: A Bibliography 1954 - 1964

DTIC Science & Technology

1966-01-01

August 1958. 498 Stringer, Roger. " Pro Nobis Astra" (Class of 󈨁 selects its ring), Talon 5;5, May 1960. 499 Trotogott, Pete. Cadet...relate to establishing an air academy. These are not included since they have no specific bearing on the Academy as it now exists. The Library staff...Newsletter AF Times - Air Force Times Air Cond Heat & Ven - Air Conditioning, Heating, and Venti- lating Air Force Airman Air Power Historian

Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors.

PubMed

Basile, Kevin J; Le, Kaitlyn; Hartsough, Edward J; Aplin, Andrew E

2014-05-01

Vemurafenib and dabrafenib block MEK-ERK1/2 signaling and cause tumor regression in the majority of advanced-stage BRAF(V600E) melanoma patients; however, acquired resistance and paradoxical signaling have driven efforts for more potent and selective RAF inhibitors. Next-generation RAF inhibitors, such as PLX7904 (PB04), effectively inhibit RAF signaling in BRAF(V600E) melanoma cells without paradoxical effects in wild-type cells. Furthermore, PLX7904 blocks the growth of vemurafenib-resistant BRAF(V600E) cells that express mutant NRAS. Acquired resistance to vemurafenib and dabrafenib is also frequently driven by expression of mutation BRAF splice variants; thus, we tested the effects of PLX7904 and its clinical analog, PLX8394 (PB03), in BRAF(V600E) splice variant-mediated vemurafenib-resistant cells. We show that paradox-breaker RAF inhibitors potently block MEK-ERK1/2 signaling, G1/S cell cycle events, survival and growth of vemurafenib/PLX4720-resistant cells harboring distinct BRAF(V600E) splice variants. These data support the further investigation of paradox-breaker RAF inhibitors as a second-line treatment option for patients failing on vemurafenib or dabrafenib. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Aircrew cooperation in the Royal Air Force

NASA Technical Reports Server (NTRS)

Adcock, C. B.

1987-01-01

The progressive introduction of modern, high performance aircraft, coupled with a significant increase in the complexity of the operational environment, has highlighted crew co-operation as a critical factor in aircraft safety. Investigation into recent MAC aircraft accidents supports the conclusion reached by NASA and other U.S. research institutions that a positive training program is required to improve resource management in the cockpit and prevent a breakdown under stress of the crew process. Past training and regulation has concentrated on the attainment of individual flying skills, but group skills have been neglected through lack of knowledge and understanding of the group process. This long-standing deficiency is now being addressed in the U.S. by the progressive and widespread introduction of theoretical and practical training programs to improve crew co-operation. The RAF should provide similar training for its aircrews through the adaptation and development of existing training resources. Better crew co-operation would not only reduce the number of RAF aircraft accidents but also improve the morale of the Service.

Analysis of Air Force Secondary Power Logistics Solution Contract

DTIC Science & Technology

2010-05-21

IL 62225 SUBJECT: Audit. Analysis of Air Force Secondary Power Logistics Solution Contract, 748th Supply Chain Management Group, Hill Air Fon:r... Power Logis.tics Solution Contnict. 748111 Supply Ch.,in Management Group. !-lill Air FOfC! BII.SI!, UT (Project 02009· DOOOCH·0213.000) I. AUlIctlcd...00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Analysis of Air Force Secondary Power Logistics Solution Contract 5a. CONTRACT NUMBER 5b. GRANT

Management and Oversight of Services Acquisition Within the United States Air Force

DTIC Science & Technology

2008-12-01

Air Mobility Command AFDW Air Force District of Washington AFSPC Air Force Space Command AT&L Acquisition Technologies and Logistics CPM ...were commonly performed in industry. The types of services included advertising for Navy recruitment, custodial services on Air Force bases, and on

Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.

PubMed

Shemon, Anne N; Eves, Eva M; Clark, Matthew C; Heil, Gary; Granovsky, Alexey; Zeng, Lingchun; Imamoto, Akira; Koide, Shohei; Rosner, Marsha Rich

2009-06-24

Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in locostatin function. We analyzed locostatin interaction with RKIP and examined the biological consequences of locostatin binding on RKIP function. NMR studies show that a locostatin precursor binds to the conserved phosphatidylethanolamine binding pocket of RKIP. However, drug binding to the pocket does not prevent RKIP association with its inhibitory target, Raf-1, nor affect RKIP phosphorylation by Protein Kinase C at a regulatory site. Similarly, exposure of wild type, RKIP-depleted HeLa cells or RKIP-deficient (RKIP(-/-)) mouse embryonic fibroblasts (MEFs) to locostatin has no effect on MAP kinase activation. Locostatin treatment of wild type MEFs causes inhibition of cell migration following wounding. RKIP deficiency impairs migration further, indicating that RKIP protects cells against locostatin-mediated inhibition of migration. Locostatin treatment of depleted or RKIP(-/-) MEFs reveals cytoskeletal disruption and microtubule abnormalities in the spindle. These results suggest that locostatin's effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling. The protective effect of RKIP against drug inhibition of migration suggests a new role for RKIP in potentially sequestering toxic compounds that may have deleterious effects on cells.

Is the canonical RAF-MEK-ERK signaling pathway a therapeutic target in SCLC?

PubMed Central

Cristea, Sandra; Sage, Julien

2017-01-01

The activity of the RAF-MEK-ERK signaling pathway is critical for the proliferation of normal and cancerous cells. Oncogenic mutations driving the development of lung adenocarcinoma often activate this signaling pathway. In contrast, pathway activity levels and their biological roles are not well established in small cell lung cancer (SCLC), a fast-growing neuroendocrine lung cancer subtype. Here we discuss the function of the RAF-MEK-ERK kinase pathway and the mechanisms leading to its activation in SCLC cells. In particular, we argue that activation of this pathway may be beneficial to the survival, proliferation and spread of SCLC cells in response to multiple stimuli. We also consider evidence that high levels of RAF-MEK-ERK pathway activity may be detrimental to SCLC tumors, including in part by interfering with their neuroendocrine fate. Based on these observations, we examine when small molecules targeting kinases in the RAF-MEK-ERK pathway may be useful therapeutically in SCLC patients, including in combination with other therapeutic agents. PMID:27133774

32 CFR 855.7 - Conditions for use of Air Force airfields.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Conditions for use of Air Force airfields. 855.7 Section 855.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Civil Aircraft Landing Permits § 855.7...

32 CFR 855.7 - Conditions for use of Air Force airfields.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Conditions for use of Air Force airfields. 855.7 Section 855.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Civil Aircraft Landing Permits § 855.7...

32 CFR 855.7 - Conditions for use of Air Force airfields.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Conditions for use of Air Force airfields. 855.7 Section 855.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Civil Aircraft Landing Permits § 855.7...

32 CFR 855.7 - Conditions for use of Air Force airfields.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Conditions for use of Air Force airfields. 855.7 Section 855.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Civil Aircraft Landing Permits § 855.7...

32 CFR 855.7 - Conditions for use of Air Force airfields.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Conditions for use of Air Force airfields. 855.7 Section 855.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Civil Aircraft Landing Permits § 855.7...

Air Force Reserve Command

Science.gov Websites

Page Get One Now AFR Mission and Vision Statement Social Media Facebook Logo #AlwaysThere Facebook Logo Technician job vacancies on USAJobs.gov 2017 AFR Modernization Book AFR Vision and Guiding Principles 2013 AFR Vision Update 2015 Contact Air Force Reserve AFRC Public Affairs AF Reserve Recruiting Service

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).

PubMed

Poulikakos, Poulikos I; Persaud, Yogindra; Janakiraman, Manickam; Kong, Xiangju; Ng, Charles; Moriceau, Gatien; Shi, Hubing; Atefi, Mohammad; Titz, Bjoern; Gabay, May Tal; Salton, Maayan; Dahlman, Kimberly B; Tadi, Madhavi; Wargo, Jennifer A; Flaherty, Keith T; Kelley, Mark C; Misteli, Tom; Chapman, Paul B; Sosman, Jeffrey A; Graeber, Thomas G; Ribas, Antoni; Lo, Roger S; Rosen, Neal; Solit, David B

2011-11-23

Activated RAS promotes dimerization of members of the RAF kinase family. ATP-competitive RAF inhibitors activate ERK signalling by transactivating RAF dimers. In melanomas with mutant BRAF(V600E), levels of RAS activation are low and these drugs bind to BRAF(V600E) monomers and inhibit their activity. This tumour-specific inhibition of ERK signalling results in a broad therapeutic index and RAF inhibitors have remarkable clinical activity in patients with melanomas that harbour mutant BRAF(V600E). However, resistance invariably develops. Here, we identify a new resistance mechanism. We find that a subset of cells resistant to vemurafenib (PLX4032, RG7204) express a 61-kDa variant form of BRAF(V600E), p61BRAF(V600E), which lacks exons 4-8, a region that encompasses the RAS-binding domain. p61BRAF(V600E) shows enhanced dimerization in cells with low levels of RAS activation, as compared to full-length BRAF(V600E). In cells in which p61BRAF(V600E) is expressed endogenously or ectopically, ERK signalling is resistant to the RAF inhibitor. Moreover, a mutation that abolishes the dimerization of p61BRAF(V600E) restores its sensitivity to vemurafenib. Finally, we identified BRAF(V600E) splicing variants lacking the RAS-binding domain in the tumours of six of nineteen patients with acquired resistance to vemurafenib. These data support the model that inhibition of ERK signalling by RAF inhibitors is dependent on levels of RAS-GTP too low to support RAF dimerization and identify a novel mechanism of acquired resistance in patients: expression of splicing isoforms of BRAF(V600E) that dimerize in a RAS-independent manner.

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

PubMed Central

Poulikakos, Poulikos I.; Persaud, Yogindra; Janakiraman, Manickam; Kong, Xiangju; Ng, Charles; Moriceau, Gatien; Shi, Hubing; Atefi, Mohammad; Titz, Bjoern; Gabay, May Tal; Salton, Maayan; Dahlman, Kimberly B.; Tadi, Madhavi; Wargo, Jennifer A.; Flaherty, Keith T.; Kelley, Mark C.; Misteli, Tom; Chapman, Paul B.; Sosman, Jeffrey A.; Graeber, Thomas G.; Ribas, Antoni; Lo, Roger S.; Rosen, Neal; Solit, David B.

2011-01-01

Summary Activated RAS promotes dimerization of members of the RAF kinase family1-3. ATP-competitive RAF inhibitors activate ERK signaling4-7 by transactivating RAF dimers4. In melanomas with mutant BRAF(V600E), levels of RAS activation are low and these drugs bind to BRAF(V600E) monomers and inhibit their activity. This tumor-specific inhibition of ERK signaling results in a broad therapeutic index and RAF inhibitors have remarkable clinical activity in patients with melanomas that harbor mutant BRAF(V600E)8. However, resistance invariably develops. Here, we identify a novel resistance mechanism. We find that a subset of cells resistant to vemurafenib (PLX4032, RG7204) express a 61kd variant form of BRAF(V600E) that lacks exons 4-8, a region that encompasses the RAS-binding domain. p61BRAF(V600E) exhibits enhanced dimerization in cells with low levels of RAS activation, as compared to full length BRAF(V600E). In cells in which p61BRAF(V600E) is expressed endogenously or ectopically, ERK signaling is resistant to the RAF inhibitor. Moreover, a mutation that abolishes the dimerization of p61BRAF(V600E) restores its sensitivity to vemurafenib. Finally, we identified BRAF(V600E) splicing variants lacking the RAS-binding domain in the tumors of six of 19 patients with acquired resistance to vemurafenib. These data support the model that inhibition of ERK signaling by RAF inhibitors is dependent on levels of RAS-GTP too low to support RAF dimerization and identify a novel mechanism of acquired resistance in patients: expression of splicing isoforms of BRAF(V600E) that dimerize in a RAS-independent manner. PMID:22113612

Processing Multiyear Procurement (MYP) Submissions - A Handbook for Air Force Program Offices

DTIC Science & Technology

1985-05-01

Contracting and Manufacturing Policy; "Policy Letter 84-1l - Multiyear Contracting Guidance" Headquarters, United States Air Force, Washington, D.C...supplement to Air Force FAR Sup No. 17.191: as enclosed in Thomas E. Lloyd, Colonel, USAF, Assistant DCS/Contracting , and Manufacturing , "DCS...Contracting and Manufacturing Policy Letter 84-16, Multiyear Contracting Guidance." Headquarters, Air Force Systems Command, Andrew Air Force Base

Task force on deterrence of air piracy : final report.

DOT National Transportation Integrated Search

1978-11-01

In February 1969, as the frequency of hijacking of U.S. air carrier aircraft was rising to an all-time high, the Federal Aviation Administration established a multi-disciplinary Task Force on Deterrence of Air Piracy. The work of the Task Force in de...

Integrated modulation of phorbol ester-induced Raf activation in EL4 lymphoma cells.

PubMed

Han, Shujie; Meier, Kathryn E

2009-05-01

The EL4 murine lymphoma cell line exists in variant phenotypes that differ with respect to responses to the tumor promoter phorbol 12-myristate 13-acetate (PMA1). Previous work showed that "PMA-sensitive" cells, characterized by a high magnitude of PMA-induced Erk activation, express RasGRP, a phorbol ester receptor that directly activates Ras. In "PMA-resistant" and "intermediate" EL4 cell lines, PMA induces Erk activation to lesser extents, but with a greater response in intermediate cells. In the current study, these cell lines were used to examine mechanisms of Raf-1 modulation. Phospho-specific antibodies were utilized to define patterns and kinetics of Raf-1 phosphorylation on several sites. Further studies showed that Akt is constitutively activated to a greater extent in PMA-resistant than in PMA-sensitive cells, and also to a greater extent in resistant than intermediate cells. Akt negatively regulates Raf-1 activation (Ser259), partially explaining the difference between resistant and intermediate cells. Erk activation exerts negative feedback on Raf-1 (Ser289/296/301), thus resulting in earlier termination of the signal in cells with a higher level of Erk activation. RKIP, a Raf inhibitory protein, is expressed at higher levels in resistant cells than in sensitive or intermediate cells. Knockdown of RKIP increases Erk activation and also negative feedback. In conclusion, this study delineates Raf-1 phosphorylation events occurring in response to PMA in cell lines with different extents of Erk activation. Variations in the levels of expression and activation of multiple signaling proteins work in an integrated fashion to modulate the extent and duration of Erk activation.

INTEGRATED MODULATION OF PHORBOL ESTER-INDUCED RAF ACTIVATION IN EL4 LYMPHOMA CELLS

PubMed Central

Han, Shujie; Meier, Kathryn E.

2009-01-01

The EL4 murine lymphoma cell line exists in variant phenotypes that differ with respect to responses to the tumor promoter phorbol 12-myristate 13-acetate (PMA1). Previous work showed that “PMA-sensitive” cells, characterized by a high magnitude of PMA-induced Erk activation, express RasGRP, a phorbol ester receptor that directly activates Ras. In “PMA-resistant” and “intermediate” EL4 cell lines, PMA induces Erk activation to lesser extents, but with a greater response in intermediate cells. In the current study, these cell lines were used to examine mechanisms of Raf-1 modulation. Phospho-specific antibodies were utilized to define patterns and kinetics of Raf-1 phosphorylation on several sites. Further studies showed that Akt is constitutively activated to a greater extent in PMA-resistant than in PMA-sensitive cells, and also to a greater extent in resistant than intermediate cells. Akt negatively regulates Raf-1 activation (Ser259), partially explaining the difference between resistant and intermediate cells. Erk activation exerts negative feedback on Raf-1 (Ser289/296/301), thus resulting in earlier termination of the signal in cells with a higher level of Erk activation. RKIP, a Raf inhibitory protein, is expressed at higher levels in resistant cells than in sensitive or intermediate cells. Knockdown of RKIP increases Erk activation and also negative feedback. In conclusion, this study delineates Raf-1 phosphorylation events occurring in response to PMA in cell lines with different extents of Erk activation. Variations in the levels of expression and activation of multiple signaling proteins work in an integrated fashion to modulate the extent and duration of Erk activation. PMID:19263515

The Air Force Handbook 2007

DTIC Science & Technology

2007-01-01

sPEcIfIcATIOns Weight 51,000 lb. (22,950 kg ) Range 800 miles (695 nautical miles) Armament One 30 mm GAU-8/A seven-barrel Gatling gun with over 1,150...battlefield air and space profession- als who bring unequaled accuracy, responsiveness, flexibility, and persistence to the Joint warfight. LOSS Of...approximately $12.4 billion. This loss of buying power reduced Air Force Program content by an additional $10 billion per year. Base Realignment

Annotated Bibliography of the Air Force Human Resources Laboratory Technical Reports - 1979.

DTIC Science & Technology

1981-05-01

Force Human Resources Laboratory, March 1980. (Covers all AFHRL projects.) NTIS. This document provides the academic and industrial R&D community with...D-AI02 04𔃾 AIR FORCE HUMAN RESOURCES LAB BROOKS AF TX F/G 5/2 ANNOTATED BIBLIOGRAPHY OF THE AIR FORCE HUMAN RESOURCES LABORAT--ETC(U) MAY 81 E M...OF THE AIR FORCE HUMAN RESOURCES LABORATORY TECHNICAL REPORTS - 1979U M By M Esther M. Barlow A N TECHNICAL SERVICES DIVISION Brooks Air Force Base

32 CFR 728.25 - Army and Air Force National Guard personnel.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

32 CFR 728.25 - Army and Air Force National Guard personnel.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

32 CFR 728.25 - Army and Air Force National Guard personnel.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

32 CFR 728.25 - Army and Air Force National Guard personnel.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

The Air Force Research Laboratory’s In-Space Propulsion Program

DTIC Science & Technology

2015-02-01

Air Force Research Laboratory (AFMC) AFRL /RQRS 1 Ara...MONITOR’S ACRONYM(S) Air Force Research Laboratory (AFMC) AFRL /RQR 5 Pollux Drive 11. SPONSOR/MONITOR’S REPORT Edwards AFB CA 93524-7048 NUMBER(S) AFRL ...illustrate the rationale behind AFRL’s technology development strategy. INTRODUCTION The Air Force Research Laboratory ( AFRL ) is the technology

32 CFR 644.475 - Excessing Army military and Air Force property.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Excessing Army military and Air Force property... the Related Land) § 644.475 Excessing Army military and Air Force property. The procedures for placing... commander concerned is required. When, under AFR 87-4, the responsible DE is called upon by the Air Force...

Air Force Materiel Command: A Survey of Performance Measures

DTIC Science & Technology

2004-03-12

AIR FORCE MATERIEL COMMAND: A SURVEY OF PERFORMANCE MEASURES THESIS Marcia Leonard, Capt...AFIT/GLM/ENS/04-10 AIR FORCE MATERIEL COMMAND: A SURVEY OF PERFORMANCE MEASURES THESIS Presented to the Faculty...SURVEY OF PERFORMANCE MEASURES Marcia Leonard, BS Capt, USAF Approved: //signed// 12 March 2004

Modeling U.S. Air Force Occupational Health Costs

DTIC Science & Technology

2009-03-01

for the 75th Aerospace Medicine Group, Hill Air Force Base, Utah. Bioenvironmental engineers sought a more robust cost comparison tool, allowing...to Major Feltenberger and Major Johns at the Air Force Medical Operations Agency and Captain Batchellor from the 75th Aerospace Medicine Squadron...resources on support functions is challenging, and rightly so. In a sense, commanders are fiduciaries to the taxpayers and must responsibly spend

The Air Force and Diversity: The Awkward Embrace

DTIC Science & Technology

2014-06-01

Space Power Journal | 105 Streeter The Air Force and Diversity Feature eling an intelligence problem at the tactical level, through developing a...careers.2 Discordance exists between Air Force intentions vis-à-vis diversity and any effective programs and policies to retain and develop a di...though the service has initiated formal di- versity efforts, recommended policy and development programs may help develop and retain competent

76 FR 22083 - U.S. Air Force Academy Board of Visitors Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

...'t Tell'' way ahead; an Air Force perspective on Diversity; an Ethics briefing; and Air Force Academy... DEPARTMENT OF DEFENSE Department of the Air Force U.S. Air Force Academy Board of Visitors Notice of Meeting AGENCY: U.S. Air Force Academy Board of Visitors. ACTION: Meeting notice. SUMMARY...

76 FR 71333 - U.S. Air Force Academy Board of Visitors Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-17

... Don't Tell;'' a National and Air Force perspective on Diversity; the Air Force Academy Athletic... DEPARTMENT OF DEFENSE Department of the Air Force U.S. Air Force Academy Board of Visitors Notice of Meeting AGENCY: U.S. Air Force Academy Board of Visitors. ACTION: Meeting notice. SUMMARY: In...

Effects of Forced Air Warming on Airflow around the Operating Table.

PubMed

Shirozu, Kazuhiro; Kai, Tetsuya; Setoguchi, Hidekazu; Ayagaki, Nobuyasu; Hoka, Sumio

2018-01-01

Forced air warming systems are used to maintain body temperature during surgery. Benefits of forced air warming have been established, but the possibility that it may disturb the operating room environment and contribute to surgical site contamination is debated. The direction and speed of forced air warming airflow and the influence of laminar airflow in the operating room have not been reported. In one institutional operating room, we examined changes in airflow speed and direction from a lower-body forced air warming device with sterile drapes mimicking abdominal surgery or total knee arthroplasty, and effects of laminar airflow, using a three-dimensional ultrasonic anemometer. Airflow from forced air warming and effects of laminar airflow were visualized using special smoke and laser light. Forced air warming caused upward airflow (39 cm/s) in the patient head area and a unidirectional convection flow (9 to 14 cm/s) along the ceiling from head to foot. No convection flows were observed around the sides of the operating table. Downward laminar airflow of approximately 40 cm/s counteracted the upward airflow caused by forced air warming and formed downward airflow at 36 to 45 cm/s. Downward airflows (34 to 56 cm/s) flowing diagonally away from the operating table were detected at operating table height in both sides. Airflow caused by forced air warming is well counteracted by downward laminar airflow from the ceiling. Thus it would be less likely to cause surgical field contamination in the presence of sufficient laminar airflow.

Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome.

PubMed

Urosevic, Jelena; Sauzeau, Vincent; Soto-Montenegro, María L; Reig, Santiago; Desco, Manuel; Wright, Emma M Burkitt; Cañamero, Marta; Mulero, Francisca; Ortega, Sagrario; Bustelo, Xosé R; Barbacid, Mariano

2011-03-22

RASopathies are a class of developmental syndromes that result from congenital mutations in key elements of the RAS/RAF/MEK signaling pathway. A well-recognized RASopathy is the cardio-facio-cutaneous (CFC) syndrome characterized by a distinctive facial appearance, heart defects, and mental retardation. Clinically diagnosed CFC patients carry germ-line mutations in four different genes, B-RAF, MEK1, MEK2, and K-RAS. B-RAF is by far the most commonly mutated locus, displaying mutations that most often result in constitutive activation of the B-RAF kinase. Here, we describe a mouse model for CFC generated by germ-line expression of a B-RafLSLV600E allele. This targeted allele allows low levels of expression of B-RafV600E, a constitutively active B-Raf kinase first identified in human melanoma. B-Raf+/LSLV600E mice are viable and display several of the characteristic features observed in CFC patients, including reduced life span, small size, facial dysmorphism, cardiomegaly, and epileptic seizures. These mice also show up-regulation of specific catecholamines and cataracts, two features detected in a low percentage of CFC patients. In addition, B-Raf+/LSLV600E mice develop neuroendocrine tumors, a pathology not observed in CFC patients. These mice may provide a means of better understanding the pathophysiology of at least some of the clinical features present in CFC patients. Moreover, they may serve as a tool to evaluate the potential therapeutic efficacy of B-RAF inhibitors and establish the precise window at which they could be effective against this congenital syndrome.

Measurement of Aerosolization of Asbestos from Soil Using the Releasable Asbestos Field Sampler (RAFS)

EPA Science Inventory

Releasable Asbestos Field Sampler (RAFS) was designed to provide an alternative to activity-based sampling (ABS) for determining likely asbestos exposure resulting from activities at site with low contaminant levels. This paper presents a description of the RAFS device and a comp...

Raf Kinase Inhibitory Protein Protects Cells against Locostatin-Mediated Inhibition of Migration

PubMed Central

Shemon, Anne N.; Eves, Eva M.; Clark, Matthew C.; Heil, Gary; Granovsky, Alexey; Zeng, Lingchun; Imamoto, Akira

2009-01-01

Background Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in locostatin function. Methods/Findings We analyzed locostatin interaction with RKIP and examined the biological consequences of locostatin binding on RKIP function. NMR studies show that a locostatin precursor binds to the conserved phosphatidylethanolamine binding pocket of RKIP. However, drug binding to the pocket does not prevent RKIP association with its inhibitory target, Raf-1, nor affect RKIP phosphorylation by Protein Kinase C at a regulatory site. Similarly, exposure of wild type, RKIP-depleted HeLa cells or RKIP-deficient (RKIP−/−) mouse embryonic fibroblasts (MEFs) to locostatin has no effect on MAP kinase activation. Locostatin treatment of wild type MEFs causes inhibition of cell migration following wounding. RKIP deficiency impairs migration further, indicating that RKIP protects cells against locostatin-mediated inhibition of migration. Locostatin treatment of depleted or RKIP−/− MEFs reveals cytoskeletal disruption and microtubule abnormalities in the spindle. Conclusions/Significance These results suggest that locostatin's effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling. The protective effect of RKIP against drug inhibition of migration suggests a new role for RKIP in potentially sequestering toxic compounds that may have deleterious effects on cells. PMID:19551145

Back to the Future: Does History Support the Expeditionary Air Force Concept?

DTIC Science & Technology

2000-04-01

Operations Forces 550, “Agile Combat Support,” Mr. Ron Orr, USAF/IL, 2 Feb 00. 4 Davis, pg. 11. 5 Toulmin , H.A., Jr., Air Service, American...John A., “The Expeditionary Air Force Takes Shape,” Air Force Magazine, Vol. 80, No. 6, June 1997. Toulmin , H.A., Jr., Air Service, American

Spiritual Development for Strategic Leadership in the Air Force

DTIC Science & Technology

2010-03-01

millionaire civilian pilot who had grown close to senior Air Force officials and the Thunderbirds.”8 The Thunderbirds are the Air Force’s high...integrated with the other well- known streams of development: cognitive, social , emotional, and moral. The name commonly given is spiritual...and socialize the Air Force core values of “Integrity First, Service Before Self, and Excellence in All We Do,” adopted in 1997. This document states

2009 Strategic Plan, Air Force District of Washington (AFDW)

DTIC Science & Technology

2009-09-11

JTF CapMed . As the Air Force single voice for Joint matters in the NCR, AFDW has a critical responsibility to protect and enhance the Air...and its surrounding counties, is a critical Area of Responsibility (AOR) for US military organizations. It is the central hub of US political and...NCR and worldwide. Furthermore, AFDW presents forces to Joint Task Force-National Capital Region Medical Command (JTF CapMed ) and, through the

Parenting Attitudes of Expectant Couples Associated with the Air Force

DTIC Science & Technology

1992-05-01

child abuse . These factors are also associated with Air Force life. These inherent risk factors when coupled with negative or abusive parenting attitudes could lead to child abuse . Little attention has been given to parenting attitudes in the Air Force population. Data were collected from a convenience sample of 67 participants in either the new OB orientation classes or the prepared child birth classes at two Air Force bases in the Southwest. The instrument was the Adult-Adolescent Parenting Inventory

Focused Logistics; What the Air Force Brings to the Fight

DTIC Science & Technology

2002-04-09

Agency partnered to develop a Strategic Distribution Management Initiative that support the Air Force’s logistics transformation and is linked by Global Command and Control System and Global Combat Support System-Air Force.

DETAIL, CONTROL BOOTH, RP1 TANK FARM Edwards Air Force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL, CONTROL BOOTH, RP1 TANK FARM - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Combined Fuel Storage Tank Farm, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

The Maharaja’s New AVTAAR: Air-Refuelling Strategy for the Indian Air Force

DTIC Science & Technology

2013-06-01

and Lolita C Baldor, "Boeing gets $35 Billion Air Force Tanker Order," Aviation on NBC News.com. Feruary 24, 2011. http://www.nbcnews.com/id/41766812...rakshak.com/NAVY/Ships/Active/156-Nicobar-Class.html (accessed March 23, 2013). Cassata, Donna, and Lolita C Baldor. "Boeing gets $35 Billion Air Force

Improving Development Teams to Support Deliberate Development of Air Force Officers

DTIC Science & Technology

2015-01-01

the USAF Cyber Force (Scott et al., 2010) • Understrength Air Force Officer Career Fields: A Force Management Approach ( Galway et al., 2005...D., “The New Way of Officer Assignments,” Air Force Magazine, June 1998, pp. 64–67. Galway , Lionel A., Richard J. Buddin, Michael R. Thirtle, Peter

TOTAL FORCE INTEGRATION: PROVIDING STABILITY FOR CITIZEN SOLDIERS IN AN EVER CHANGING AIR FORCE

DTIC Science & Technology

2016-10-01

Active Duty manpower vacancies, such as Air Force Reserve Officer Training Corps (AFROTC) instructor duties, are being filled through unique...has invested in a variety of ways to fill manpower gaps, to include using enlisted Active Duty members to conduct what was previously considered...entire Air Force airlift mission, resulting in substantial stressors on civilian careers and family life, which has always been the cornerstone of

Transformation in the French Air Force in an Era of Change

DTIC Science & Technology

2008-01-01

Abria.indd 6 10/30/08 1:15:37 PM Transformation in the French Air Force in an Era of Change Général d’armée aérienne Stéphane Abrial, chef...l’armée l’air,” sponsored by the Centre d’études stratégiques aérospatiales, 3 June 2008. The French Air Force, like all defense organizations...related to our equipment, because the French aircraft Gen Stéphane Abrial is the chief of staff of the French Air Force. He completed the French Air

B-52 Stratofortress > U.S. Air Force > Fact Sheet Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

How Does the Air Force Create Effective Accountability for Initial Spares?

DTIC Science & Technology

1990-05-01

effective accountability for initial spares? AUTHOR: Pamela J. Henson, Civilian, USAF The accountability for acquisition cost , schedule, and...in place to allow the Program Manager to effectively manage this cost element. Initial spares have traditionally been managed in Air Force Logistics...at Maxwell Air Force Base. Pamela became the Chief, Cost Analysis Division at HQ Air Force Logistics Command in 1987, where she received the Civilian

Achieving the Air Force’s Energy Vision

DTIC Science & Technology

2011-01-01

sor of logistics and supply chain management at AFIT. The US Air Force is the largest con -sumer of energy in the federal gov-ernment, spending $9...technology, motors , advanced bat- teries, and ultracapacitors. AFIT is playing a critical role in meeting Air Force and industry demand for more...Flight Design displayed a parallel hybrid-electric propul- sion system with an ICE and electric motor (fig. 2) for a general aviation aircraft. A

COIN in Cyberspace: Focusing Air Force Doctrine Development

DTIC Science & Technology

2007-01-01

cyberspace and began codifying its cyber warfare doctrine. This effort is hampered, however, by a limited understanding of cyberspace by rank and file Air...Force members. Many believe cyberspace and cyber warfare are the responsibility of the communications community. If this new doctrine is to be...doctrine to build upon, the Air Force can create unity of effort among Airmen at all levels, ensure unity of purpose in the prosecution of cyber warfare , and

The U.S. Air Force Aeromedical Evacuation Mission: A Mission for the Air Reserve Components

DTIC Science & Technology

2016-02-01

AU/ACSC/2016 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY THE U.S. AIR FORCE AEROMEDICAL EVACUATION MISSION: A MISSION FOR THE AIR RESERVE...Aeromedical Evacuation ............................................................................................................. 7 The Current Problem...13 Evaluation

Air Force Handbook. 109th Congress

DTIC Science & Technology

2009-01-01

FY06 Combat Survivor Evader Locator (CSEL) Acquisition Status Capabilities/Profile Functions /Performance Parameters 38 • Air Force’s primary source for...Broadcast Service (GBS) Capabilities/Profile Acquisition Status Functions /Performance Parameters • Purchase Requirements (Phase 2): • 3 primary ...Operations (AF CONOPS) that support the CSAF and joint vision of combat operations. • AF CONOPS describe key Air Force mission and/or functional areas

Wireless Sensor Network Applications for the Combat Air Forces

DTIC Science & Technology

2006-06-13

WIRELESS SENSOR NETWORK APPLICATIONS FOR THE COMBAT AIR FORCES GRADUATE RESEARCH PROJECT...Government. AFIT/IC4/ENG/06-05 WIRELESS SENSOR NETWORK APPLICATIONS FOR THE COMBAT AIR FORCES GRADUATE RESEARCH PROJECT Presented to the...Major, USAF June 2006 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED AFIT/IC4/ENG/06-05 WIRELESS SENSOR NETWORK APPLICATIONS

Helical Explosive Flux Compression Generator Research at the Air Force Research Laboratory

DTIC Science & Technology

1999-06-01

Air Force Research Laboratory Kirtland AFB...ORGANIZATION NAME(S) AND ADDRESS(ES) Directed Energy Directorate, Air Force Research Laboratory Kirtland AFB, NM 8. PERFORMING ORGANIZATION REPORT...in support of the Air Force Research Laboratory ( AFRL ) explosive pulsed power program. These include circuit codes such as Microcap and

Task analysis of Air Force pharmacy practice.

PubMed

Bartholomew, A; Sawyer, W T; Coats, L

1995-01-15

The frequency with which United States Air Force pharmacists perform specific professional tasks and the pharmacists' views as to the importance of those tasks were studied. A questionnaire was prepared that asked recipients to rate each of 36 tasks selected as representing the spectrum of practice activities. There were four categories of tasks: managerial tasks, dispensing tasks, drug information tasks, and patient care tasks. Recipients rated the tasks with respect to frequency of performance and importance on separate 6-point scales. The questionnaire was mailed in May 1991 to the 225 pharmacists then serving in the Air Force worldwide. Of the 225 questionnaires, 150 usable questionnaires were returned (response rate, 67%). All the tasks in the survey were performed by at least one Air Force pharmacy officer, although the frequency of task performance varied. In particular, the frequency of many patient care tasks was low. All the tasks were perceived to have some importance, but drug information tasks were rated as being significantly more important than tasks in the other categories; patient care tasks were rated lowest in importance. The results varied with the respondents' demographic characteristics. Pharmacy officers with more years of service, more senior positions, higher rank, or an advanced degree in a field other than pharmacy tended to give responses that diverged from those of the population. A 1991 survey showed an awareness among Air Force pharmacists of the need to orient practice around patient care; however, they were not spending substantial time on patient care and tended to view it as less important than more traditional pharmacy tasks.

Air Force Air Refueling for Naval Operations: History, Practice, and Recommendations

DTIC Science & Technology

1990-08-01

Air Force Air Refueling 0 ELECTE C4 N 910U for BU Naval Operations History, Practice, and Recommendations UtMON STA~IMENT X [ Apov.e ,opu,. Lt Col...as three hose reels provide redundancy over just one. 13. Be used in coordination with carriler -launched buddy tankers, there- by providing the

Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient mice.

PubMed

Saher, G; Hildt, E

1999-09-24

Integrin alpha(7)-deficient mice develop a novel form of muscular dystrophy. Here we report that deficiency of alpha(7) integrin causes an activation of the c-Raf-1/mitogen-activated protein (MAP) 2 kinase signal transduction pathway in muscle cells. The observed activation of c-Raf-1/MAP2 kinases is a specific effect, because the alpha(7) integrin deficiency does not cause unspecific stress as determined by measurement of the Hsp72/73 level and activity of the JNK2 kinase. Because an increased level of activated FAK was found in muscle of alpha(7) integrin-deficient mice, the activation of c-Raf-1 kinase is triggered most likely by an integrin-dependent pathway. In accordance with this, in the integrin alpha(7)-deficient mice, part of the integrin beta(1D) variant in muscle is replaced by the beta(1A) variant, which permits the FAK activation. A recent report describes that integrin activity can be down-modulated by the c-Raf-1/MAP2 kinase pathway. Specific activation of the c-Raf-1/MAP2 kinases by cell-permeable peptides in skeletal muscle of rabbits causes degeneration of muscle fibers. Therefore, we conclude that in alpha(7) integrin-deficient mice, the continuous activation of c-Raf-1 kinase causes a permanent reduction of integrin activity diminishing integrin-dependent cell-matrix interactions and thereby contributing to the development of the dystrophic phenotype.

Air Force Cyber Outreach

DTIC Science & Technology

2017-09-17

design process requires teams to analyze and organize information in a manner that communicates efficiently with stakeholders. This communication is...share information (with each other and local school districts) on available/applicable grants b. How to help school districts identify and/or...graphed below. The graph compares the advance’s relative impact on the ability of the Air Force to maintain 12 information and decision dominance (x

In Search of an Identity: Air Force Core Competencies

DTIC Science & Technology

1997-06-01

for connecting core competencies to both inside and outside the service . Core competencies have become a decision making framework for the Air Force...Proposed Intra– Service Relationship ................................................................. 76 Figure 2. Proposed Inter- service and Joint...connecting core competencies to both inside and outside the service . Core competencies have become a decision making framework for the Air Force. They

Preliminary Evaluation of the Effectiveness of Air Force Advertising.

ERIC Educational Resources Information Center

Vitola, Bart M.

The Airman Enlistment Questionnaire was administered to a sample of non prior service enlistees, 1,667 males and 300 females. Analysis of the responses shows (1)educational opportunity is the strongest motivator for enlisting in the Air Force; (2) there is an indication that Air Force advertising should make different appeals to men and women; and…

Identification of novel B-RafV600E inhibitors employing FBDD strategy.

PubMed

Wang, Peng-Fei; Qiu, Han-Yue; Wang, Ze-Feng; Zhang, Yong-Jiao; Wang, Zhong-Chang; Li, Dong-Dong; Zhu, Hai-Liang

2017-05-15

B-Raf kinase is the key point in a main branch of mitogen-activated protein kinase pathways and some of its mutations, such as the V600E mutation, lead to the persistent activation of ERK signaling and the trigger of severe diseases, including melanoma and other somatic cancers. Several potent drugs have been approved to treat B-Raf-related tumors, however, cases of resistance and relapse have been reported universally. Hence, differential scaffolds are in need to alleviate the scarcity of drugs and benefit the therapy of B-Raf-mutant cancers. Herein we report our recent work on the construction of novel B-Raf V600E inhibitors employing fragment-based drug design strategy. In this research, we decomposed known inhibitors to fragments and rebuilt new candidates using these blocks according to the evaluation of their potential. Lead compounds were synthesized after selection by means of virtual screening and molecular dynamics validation. Afterwards, we tested the pharmacological efficiency of these entities both in vitro and in vivo utilizing A375 xenograft model. The results favored our rational design intention and hinted this new kind of inhibitors might be helpful in the further explorations of potent agents. Copyright © 2017 Elsevier Inc. All rights reserved.

IS FREE REALLY FREE PALACE ACQUIRE AS AN EFFECTIVE FORCE RENEWAL SOURCE FOR AIR FORCE PUBLIC AFFAIRS

DTIC Science & Technology

2016-02-29

AU/ACSC/2016 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY IS FREE REALLY FREE ? PALACE ACQUIRE AS AN EFFECTIVE FORCE RENEWAL SOURCE FOR AIR...transfer-eligible candidates, and external applicants. Ultimately, this research reveals, the cost – in both money and manpower – does not support...these employees provide to their sponsoring offices in “ free manning.” 5 CHAPTER 1 Introduction Public Affairs is key aspect of Air Force

[Professional psychological selection system in the Air Force - 50 years].

PubMed

Pokrovskiĭ, B L

2014-08-01

Given the data about the establishment of the professional psychological selection system in the Air Force in 1958-1964 in the NIIIAM Air Force by the team psychological department under the leadership of K.K.Platonova. Given the names of the developers of this system and given the results of their research. The result of all made work the order of Air Force Commander about the introduction of the psychological selection in Higher Military Aviation School of Pilots, starting from a set of 1964 became. Recommendations for professional psychological selection of a wide range of aviation professionals in various fields, and in the future - and other professionals of the Armed Forces, became the results of future work.

The United States Air Force Reserve Officer Training Corps: Looking to the Future

DTIC Science & Technology

1991-03-04

Brigadier General Robin G. Tornow Commandant, Air Force ROTC (Note 25) Over the years, Air Force ROTC has developed many strong points. Paramount among...maintaining a leaner and more capable force for the future. Brigadier General Robin G. Tornow Commandant, Air Force ROTC (Note 35) This alternative

32 CFR 865.5 - Decision of the Secretary of the Air Force.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Decision of the Secretary of the Air Force. 865.5 Section 865.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ORGANIZATION AND MISSION-GENERAL PERSONNEL REVIEW BOARDS Air Force Board for Correction of Military Records...

32 CFR 989.7 - Requests from Non-Air Force agencies or entities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Requests from Non-Air Force agencies or entities. 989.7 Section 989.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.7 Requests from Non-Air Force...

Zero-Base Budgeting Impact on Air Force Laboratories.

DTIC Science & Technology

1980-08-01

discon- tinued. ZBB later surfaced, some think originated, at Texas Instruments, having been introduced by Peter Phyrr in 1968.21 Jimmy Carter, then...little more sense to some people and a little less to others. It just does not hang together as a presentation of agency policies. There are more...8217s the Air Force formed the Air Force Management Improvement Group to address people inter- actions and how they fit the future needs. The emphasis of

Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules

PubMed Central

Mekel, Michal; Nucera, Carmelo; Hodin, Richard A.; Parangi, Sareh

2013-01-01

BACKGROUND Management of patients with thyroid nodules is based on establishing an accurate diagnosis; however, differentiating benign from malignant lesions preoperatively is not always possible using current cytological techniques. Novel molecular testing on cytological material could lead to clearer treatment algorithms. B-RafV600E mutation is the most common genetic alteration in thyroid cancer, specifically found in papillary thyroid cancer (PTC), and usually reported to be associated with aggressive disease. DATA SOURCE A literature search using PubMed identified all the pertinent literature on the identification and utilization of the B-RafV600E mutation in thyroid cancer. CONCLUSIONS The utility of using B-Raf mutation testing for nodules with indeterminate cytology is limited since many of those nodules (benign and malignant) do not harbor B-Raf mutations. However, when the pathologist sees cytological features suspicious for PTC, B-RafV600E mutation analysis may enhance the assessment of preoperative risks for PTC, directing a more aggressive initial surgical management when appropriate. PMID:20637346

19. DETAIL OF AIR FORCE WEATHER INFORMATION TERMINAL AND CHART ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. DETAIL OF AIR FORCE WEATHER INFORMATION TERMINAL AND CHART RECORDER LOCATED IMMEDIATELY NORTH OF CONSOLE IN PHOTOS A-15 THROUGH A-18. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

An Analysis of Air Force Management of Turbine Engine Monitoring Systems (TEMS).

DTIC Science & Technology

1980-06-01

AIR FORCE AIR UNIVERSITY (ATC) C AIR FORCE INSTITUTE OF TECHNOLOGY LWright-Patterson Air Force Base, Ohio 80 9 22 057 All BBO RCE j GEMEM Elbert B...detrimental ideas, or deleterious information are contained therein. Furthermore, the views expressed in the document are those of the author(s) and...role problems, information flow and integration problems, and leadership and command problems. Four alternative management concepts were analyzed. Based

A Study of Black Officer Candidate Attrition in the United States Air Force

DTIC Science & Technology

1993-09-01

concern among Air Force accession policy officials (Travers, 1992). Prior to 1973 the Air Force, as well as all other services, was under -represented in...Although the Air Force did not exist in 1940, its predecessor, the Army Air Corps, fell under this new policy. Thus, by the time the Air Force was made a...participation increased from 0.6 percent in 1942 to approximately 2 percent by 1973. However, blacks were 3till vastly under -represented in relation to both the

Is RAF1 protein from Synechocystis sp. PCC 6803 really needed in the cyanobacterial Rubisco assembly process?

PubMed

Kolesinski, Piotr; Rydzy, Malgorzata; Szczepaniak, Andrzej

2017-05-01

Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is responsible for carbon dioxide conversion during photosynthesis and, therefore, is the most important protein in biomass generation. Modifications of this biocatalyst toward improvements in its properties are hindered by the complicated and not yet fully understood assembly process required for the formation of active holoenzymes. An entire set of auxiliary factors, including chaperonin GroEL/GroES and assembly chaperones RbcX or Rubisco accumulation factor 1 (RAF1), is involved in the folding and subsequent assembly of Rubisco subunits. Recently, it has been shown that cyanobacterial RAF1 acts during the formation of the large Rubisco subunit (RbcL) dimer. However, both its physiological function and its necessity in the prokaryotic Rubisco formation process remain elusive. Here, we demonstrate that the Synechocystis sp. PCC 6803 strain with raf1 gene disruption shows the same growth rate as wild-type cells under standard conditions. Moreover, the Rubisco biosynthesis process seems to be unperturbed in mutant cells despite the absence of RbcL-RAF1 complexes. However, in the tested environmental conditions, sulfur starvation triggers the degradation of RbcL and subsequent proteolysis of other polypeptides in wild-type but not Δraf1 strains. Pull-down experiments also indicate that, apart from Rubisco, RAF1 co-purifies with phycocyanins. We postulate that RAF1 is not an obligatory factor in cyanobacterial Rubisco assembly, but rather participates in environmentally regulated Rubisco homeostasis.

Replacing the IRAF/PyRAF Code-base at STScI: The Advanced Camera for Surveys (ACS)

NASA Astrophysics Data System (ADS)

Lucas, Ray A.; Desjardins, Tyler D.; STScI ACS (Advanced Camera for Surveys) Team

2018-06-01

IRAF/PyRAF are no longer viable on the latest hardware often used by HST observers, therefore STScI no longer actively supports IRAF or PyRAF for most purposes. STScI instrument teams are in the process of converting all of our data processing and analysis code from IRAF/PyRAF to Python, including our calibration reference file pipelines and data reduction software. This is exemplified by our latest ACS Data Handbook, version 9.0, which was recently published in February 2018. Examples of IRAF and PyRAF commands have now been replaced by code blocks in Python, with references linked to documentation on how to download and install the latest Python software via Conda and AstroConda. With the temporary exception of the ACS slitless spectroscopy tool aXe, all ACS-related software is now independent of IRAF/PyRAF. A concerted effort has been made across STScI divisions to help the astronomical community transition from IRAF/PyRAF to Python, with tools such as Python Jupyter notebooks being made to give users workable examples. In addition to our code changes, the new ACS data handbook discusses the latest developments in charge transfer efficiency (CTE) correction, bias de-striping, and updates to the creation and format of calibration reference files among other topics.

Environmental Assessment: Western Range Instrumentation Modernization Program Vandenberg Air Force Base, Santa Barbara County, and Pillar Point Air Force Station, San Mateo County California

DTIC Science & Technology

2008-09-03

Force Base ( AFB ), and Pillar Point Air Force Station (AFS), California. The 30th Space Wing at Vandenberg AFB operates the Western Launch and Test...Range (Western Range). The Western Range begins at the coastal boundaries of Vandenberg AFB and extends westward to the Marshall Islands, including...Vandenberg AFB . Vandenberg AFB is headquarters to the 30th Space Wing, the Air Force Space Command unit that operates Vandenberg AFB and the Western

Diversity Within the U.S. Air Force Senior Leadership

DTIC Science & Technology

2010-02-17

15 1 Introduction The United States Air Force is committed to equal opportunity and diversity within its ranks. According to...Office. Diversity and Equal Opportunity in Our Air Force. AFTV Video. 9 min., March 2009. 2 What is diversity and is it important? When...attributes reflect unchangeable human differences that are either inborn or developed in our early socialization . Secondary dimensions of diversity

Air Force Smart Bases

DTIC Science & Technology

2017-10-19

the future. Then to design an information and data architecture to enable many use cases for further mission experimentation and acquisition strategy...development. A key feature of the future of smart cities (or, in our case , smart bases) is that citizen engagement with one another and with their...cybersecurity on Air Force installations. Participants The design sprint brought in over 30 participants from across the military and industry

Oversight of the Air Force - What is the Audit Component and How Can Air Force Managers Deal with It Effectively?

DTIC Science & Technology

1988-05-01

This report discusses authority, mission, and responsibilities of the audit organizations that perform oversight of Air Force operations. A...the discussion of the major audit organizations. The audit oversight function is here to stay. Auditors and audit organizations can be beneficial to Air

Air Force Roles and Missions: A History

DTIC Science & Technology

1998-01-01

armies fighting on the Western Front. In July, Foch gave Pershing tactical control of a sector in the Chateau- Thierry region, with only one division...In the battle at Chateau- Thierry in July, air squadrons flying support for the American division learned a costly lesson. Air units were deci- mated... Thierry , he saw Trenchard’s views on the need to concentrate air forces to achieve aerial superiority confirmed. The losses helped Mitchell convince

Customer Management Skills for Effective Air Force Civil Engineering Customer Service.

DTIC Science & Technology

1986-09-01

advertise --competence. (1) Craftsmen working closely with customer service -doing what is promised when it’s promised -if return to job site required, tell...RD-RI74 1 4 CUSTOMER MANAGEMENT SKILLS FOR EFFECTIVE AIR FORCE / I CIVIL ENGINEERING CUST (U) AIR FORCE INST OF TECH WRIGHT-PATTERSON RFS ON...I93 -A CUSTOMER MANAGEMENT SKILLS FOR EFFECTIVE AIR FORCE CIVIL ENGINEERING CUSTOMER SERVICE THESIS Danny S.- Long Captain, USAF AFIT/GEM/DEM/86S-1 7

Measuring Air Force Contracting Customer Satisfaction

DTIC Science & Technology

2015-12-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT MEASURING AIR FORCE CONTRACTING CUSTOMER SATISFACTION ...... satisfaction elements should be included in a standardized tool that measures the level of customer satisfaction for AF Contracting’s external and

Physical Profiling Performance of Air Force Primary Care Providers

DTIC Science & Technology

2017-08-09

AFRL-SA-WP-TR-2017-0014 Physical Profiling Performance of Air Force Primary Care Providers Anthony P. Tvaryanas1; William P...COVERED (From – To) September 2016 – January 2017 4. TITLE AND SUBTITLE Physical Profiling Performance of Air Force Primary Care Providers...encounter with their primary care team. An independent medical standards subject matter expert (SME) reviewed encounters in the electronic health record

The Air Force Fitness Program and the Challenge of Creating a More Fit Force

DTIC Science & Technology

2012-06-08

their fitness habits. In the early 1990s the Air Force transitioned to the bike test. The Weight Management Program continued with little change. The...member reported that he had lost ten pounds and was walking every day. I along with my Chief Master Sergeant continued to monitor the progress of the... continually high standard. The study 12 will show that the current Air Force fitness program does provide a basic view of fitness, but it does

Fraternization in the United States Air Force: Development of a Policy Booklet

DTIC Science & Technology

1988-09-01

perspective. Military custom, the UCMJ, military court decisions, and administrative actions have all played impor- tant roles in defining and enforcing a...your contribution. Good luck on publishing your work. Good job! We need it in the field !" Maj David Barton Chief. Military Affairs. Hq ATC JAG Office...GSM/LSR/88S-5 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR FORCE INSTITUTE OF TECHNOLOGY Wright-Patterson Air Force Base, Ohio DISTPJBU1• )N

The Air Force Role in Low-Intensity Conflict

DTIC Science & Technology

1986-10-01

attempt, Kabbej was chief pilot of Royal Air Maroc , Morocco’s national airline . He was more than a pilot who happened to gain the trust of the King...Royal Air Maroc . But he kept a reserve commission in the air force. Thus, because of his active duty and reserve service, Kabbej is not regarded in

Environmental Assessment: General Plan-Based Environmental Impact Analysis Process, Laughlin Air Force Base

DTIC Science & Technology

2007-05-01

BASED ENVIROMENTAL IMPACT ANALYSIS PROCESS LAUGHLIN AIR FORCE BASE, TEXAS AGENCY: 47th Flying Training Wing (FTW), Laughlin Air Force Base (AFB), Texas...8217\\ \\ \\ \\ \\\\ \\ ~ >(- \\ , ~ AOC01 \\ PS018 / WP002 \\ DP008 // WP006 \\ ~ ,/ ’----- -----·-------------~--/·/ LAUGHLIN AIR FORCE BASE ENVIROMENTAL RESTORATION

Job Dissatisfaction among Air Force Clinical Nurses: Causes and Ways to Change It.

DTIC Science & Technology

1988-01-01

44%) of nurses planning an L Air Force career (14:--). Recognizing job satisfaction can be a major deciding factor in choosing an Air Force career ... burnout and searched for ideas on how to improve clinical nursing in the Air Force. improving job satisfaction in nursing today is a hot topic and...clinical nurses are falling victim to " burnout " syndrome, which in turn is affecting their job satisfaction . Air Force clinical inpatient nurses are managing

Setup: What the Air Force Did in Vietnam and Why

DTIC Science & Technology

1991-06-01

4, no. 2 (Fall 1950) : 12 . 18 . Ibid . 19 . Giulio Douhet, The Command ofthe Air, trans . Dino Ferrari, reprinted by the Office of Air Force History...demilitarized zone (DMZ). Ironically, in November 1954, Gen Tran Van Don and other leading Vietnamese generals suggested that the MAAG organize their...Office ofAir Force History, 1981), 36. 37 . Ibid., 49-50. 38 . According to formerSouth Vietnamese minister ofnational defense Gen Tran Van Don, he and

Why Is Outdoor Recreation Worth $30 Million to the Air Force?

ERIC Educational Resources Information Center

Heeg, Phillip

The Air Force outdoor recreation program evolved from the Army "rest and recreation" areas set up during World War II. During the last decade, financial pressures and eroding support for recreation programs forced a reexamination of the objectives of such programs. Starting with the premise that the Air Force was the main customer and…

miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.

PubMed

Chao, Chen; Li, Feng; Tan, Zhiping; Zhang, Weizhi; Yang, Yifeng; Luo, Cheng

2018-01-15

Recent reports have demonstrated that RAF-1 L613V (a mutant of RAF-1) mutant mice show bone deformities similar to Noonan syndrome. It has been suggested that RAF-1 L613V might abnormally activate osteoblast differentiation of MC3T3-E1 cells. To demonstrate that RAF-1 is associated with bone deformity and that RAF-1 L613V dependent bone deformity could be inhibited by microRNA-195 (miR-195), we first investigated the amplifying influence of wild-type RAF-1 (WT) or RAF-1 L613V (L613V) on the viability and differentiation of MC3T3-E1 cells induced by bone morphogenetic protein-2 (BMP-2) via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining, quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis. Subsequently, we investigated the blocking effect and its mechanism of miR-195 for abnormal activation of osteoblast differentiation of MC3T3-E1 cells via targeting RAF-1. RAF-1, especially RAF-1 L613V , abnormally activates osteoblast differentiation of MC3T3-E1 cells induced by BMP-2. Meanwhile, miR-195 could inhibit the cell viability and differentiation of MC3T3-E1 cells. Transfection of miR-195 largely suppressed the L613V-induced viability and osteoblast differentiation of MC3T3-E1 cells and attenuated the accelerative effect of L613V on runt-related transcription factor-2 (Runx2), Osterix (OSX), alkaline phosphatase (ALP), osteocalcin (OCN), and distal-less homeobox 5 (DLX5) osteogenic gene expressions. In addition, miR-195 decreased the expression of RAF-1 mRNA and protein by directly targeting the 3'-untranslated regions (3'-UTR) of RAF-1 mRNA in MC3T3-E1 cells. Our findings indicated that miR-195 inhibited WT and L613V RAF-1 induced hyperactive osteoblast differentiation in MC3T3-E1 cells by targeting RAF-1. miR-195 might be a novel therapeutic agent for the treatment of L613V-induced bone deformity in Noonan syndrome. Copyright © 2017. Published by

Air Force Pilot Retention-1988.

DTIC Science & Technology

1988-04-01

34 Air Force Times, 11 January 1988, pp. -" 1,12. 3. D.irbv’, Kit. "Dear Military Pilot." Future Aviation Pro- fessionals of America, ( FAPA ), 15...America ( FAPA . 0. Other professional journals or publications E. Newspapers . A. "Wurd of mouth" L. Personal contact(s) made while occupying my present

Air Force Civil Engineer, Volume 15, Number 3, 2007

DTIC Science & Technology

2007-01-01

Korea during the winter. The runway is made of pierced steel plank . (U.S. Air Force photo) Transforming Air Force Firefighting...expect the fire chief and fire marshal to inform installation leadership when the mission is potentially impacted and to advocate risk mitigation...measures, and we expect leadership to listen. The use of “manage” in the phrase indicates that FES flights are expected to manage the event to the

Air Force B-21 Long Range Strike Bomber

DTIC Science & Technology

2016-04-14

and B - 52 bombers, and would possibly replace B -2s in the future. B -21 development was highly classified until the summer of 2015, when the Air Force...Air Force had indicated that its fleet of B -1, B -2, and B - 52 bombers would suffice until 2037, when advanced technologies, such as hypersonic cruise...was the prime contractor for the B -1. Boeing was the prime contractor for the B - 52 . From FY2004 to FY2009, DOD requested more than $1.4 billion in the

Air Reserve Component: Key to the Air Force’s Future

DTIC Science & Technology

2013-03-01

REPORT TYPE STRATEGY RESEARCH PROJECT .33 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Air Reserve Component: Key to the Air Force’s...b. ABSTRACT UU c. THIS PAGE UU 19b. TELEPHONE NUMBER (Include area code) USAWC STRATEGY RESEARCH PROJECT...RAND Corporation, Prepared for the Office of Secretary of Defense, 2008), XV. 64 T.X. Hammes, "Offshore Control: A Proposed Strategy ," Infinity

Comparison of 20-, 23-, and 25-gauge air infusion forces.

PubMed

Machado, Leonardo Martins; Magalhães, Octaviano; Maia, Mauricio; Rodrigues, Eduardo B; Farah, Michel Eid; Ismail, Kamal A R; Molon, Leandro; Oliveira, Danilo A

2011-11-01

To determine and compare 20-, 23-, and 25-gauge retinal infusion air jet impact pressure (force per unit area) in an experimental setting. Experimental laboratory investigation. Infusion cannulas were connected to a compressed air system. A controlled valve mechanism was used to obtain increasing levels of infusion pressure. Each infusion tube was positioned in front of a manual transducer to measure force. Impact pressure was calculated using known formulas in fluid dynamics. The 20-gauge infusion jet showed similar impact pressure values compared with the 23-gauge infusion jet. Both showed higher levels than the 25-gauge infusion jet. This was because of the smaller jet force for the 25-gauge system. In this experimental study, both the 23- and the 20-gauge air infusion jet showed higher impact pressure values compared with the 25-gauge air infusion jet. This could be of concern regarding air infusion during 23-gauge vitrectomy since retinal damage has been shown in standard-gauge surgeries.

32 CFR 644.392 - Air Force-preliminary report of excess.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Air Force-preliminary report of excess. 644.392... PROPERTY REAL ESTATE HANDBOOK Disposal Predisposal Action § 644.392 Air Force—preliminary report of excess... Force screens its own properties for other defense requirements and clears the disposal with DOD and the...

MAJOR GENERAL PETER E. GERSTEN > U.S. Air Force > Biography Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

An Optimization of the Maintenance Assets Distribution Network in the Argentine Air Force

DTIC Science & Technology

2015-03-26

Air Force (2010). Manual de Conduccion Logistica . Buenos Aires: HQ Argentine Air Force. Argentine Air Force (2012). El vuelo del condor: 1912-2012...recommendation was made to consider organic or private transportation and reduce transportation time in order to improve responsiveness and drive down...determine overall transportation demand and capacity required for a defined level of service, and to evaluate the tradeoffs between costs and service

Cost-effectiveness of forced air warming during sedation in the cardiac catheterisation laboratory.

PubMed

Conway, Aaron; Duff, Jed; Sutherland, Joanna

2018-05-13

To determine the cost-effectiveness of forced air warming during sedation in a cardiac catheterisation laboratory. Forced air warming improves thermal comfort in comparison with standard care. It is not known whether the extra costs required for forced air warming are good value. Cost-effectiveness analysis alongside a randomised controlled trial conducted in 2016-2017. A cost-effectiveness analysis was undertaken using Monte Carlo simulations from input distributions to estimate costs and effects associated with using forced air warming to reduce risk of thermal discomfort for patients receiving sedation in a cardiac catheterisation laboratory. A range of willingness to pay threshold values were tested with results plotted on a cost-effectiveness acceptability curve. Costs were calculated in Australian currency ($AUD). Estimated total costs were $5.21 (SD 3.26) higher per patient for forced air warming in comparison to standard care. Estimated probability of success (rating of thermal comfort) was 0.16 (0.06) higher for forced air warming. Forced air warming becomes more likely to result in a net benefit than standard care at a willingness to pay threshold of $34. Forced air warming could be considered cost-effective for procedures performed with sedation in a cardiac catheterisation laboratory if the extra cost of an incremental gain in thermal comfort is less than the decision maker's willingness to pay for it. Therefore, those responsible for decision-making regarding use of forced air warming in the cardiac catheterisation laboratory can use results of our model to decide if it represents good value for their organisation. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Some Factors Influencing Air Force Simulator Training Effectiveness. Technical Report.

ERIC Educational Resources Information Center

Caro, Paul W.

A study of U.S. Air Force simulator training was conducted to identify factors that influence the effectiveness of such training and to learn how its effectiveness is being determined. The research consisted of a survey of ten representative Air Force simulator training programs and a review of the simulator training research literature. A number…

Forced-air patient warming blankets disrupt unidirectional airflow.

PubMed

Legg, A J; Hamer, A J

2013-03-01

We have recently shown that waste heat from forced-air warming blankets can increase the temperature and concentration of airborne particles over the surgical site. The mechanism for the increased concentration of particles and their site of origin remained unclear. We therefore attempted to visualise the airflow in theatre over a simulated total knee replacement using neutral-buoyancy helium bubbles. Particles were created using a Rocket PS23 smoke machine positioned below the operating table, a potential area of contamination. The same theatre set-up, warming devices and controls were used as in our previous study. This demonstrated that waste heat from the poorly insulated forced-air warming blanket increased the air temperature on the surgical side of the drape by > 5°C. This created convection currents that rose against the downward unidirectional airflow, causing turbulence over the patient. The convection currents increased the particle concentration 1000-fold (2 174 000 particles/m(3) for forced-air warming vs 1000 particles/m(3) for radiant warming and 2000 particles/m(3) for the control) by drawing potentially contaminated particles from below the operating table into the surgical site. Cite this article: Bone Joint J 2013;95-B:407-10.

Centennial Aerospace Power: The ’US Air Force’ at 100 Years

DTIC Science & Technology

2000-01-01

culture during this time will be based both on the national power status of the United States relative to the rest of the world as...must develop an information warrior culture . This culture must be information based and include the application of force through air, space, and cyber... The culture of the U.S. Air Force will have to expand from one of employing air and space forces to one of

Air Force Civil Engineer, Volume 14, Number 2, 2006

DTIC Science & Technology

2006-01-01

homes located off base), reimburs - able service agreements are created between the housing development’s project owner and both the Air Force...Just as with security, fire protection is provided by the on-base fire department on a reimbursable basis. At a recent fire at Hanscom AFB, Mass... reimbursable clients; and programming functions. Input of this “living record” allows the database to manage the 5-Year Plan so 16 AIR FORCE CIVIL

Spectral Longwave Cloud Radiative Forcing as Observed by AIRS

NASA Technical Reports Server (NTRS)

Blaisdell, John M.; Susskind, Joel; Lee, Jae N.; Iredell, Lena

2016-01-01

AIRS V6 products contain the spectral contributions to Outgoing Longwave Radiation (OLR), clear-sky OLR (OLR(sub CLR)), and Longwave Cloud Radiative Forcing (LWCRF) in 16 bands from 100 cm(exp -1) to 3260 cm(exp -1). We show climatologies of selected spectrally resolved AIRS V6 products over the period of September 2002 through August 2016. Spectrally resolved LWCRF can better describe the response of the Earth system to cloud and cloud feedback processes. The spectral LWCRF enables us to estimate the fraction of each contributing factor to cloud forcing, i.e.: surface temperature, mid to upper tropospheric water vapor, and tropospheric temperature. This presentation also compares the spatial characteristics of LWCRF from AIRS, CERES_EBAF Edition-2.8, and MERRA-2. AIRS and CERES LWCRF products show good agreement. The OLR bias between AIRS and CERES is very close to that of OLR(sub CLR). This implies that both AIRS and CERES OLR products accurately account for the effect of clouds on OLR.

Living History: Pioneering Bandswomen of the United States Air Force

ERIC Educational Resources Information Center

Nichols, Jeananne

2015-01-01

This narrative describes two United States Air Force bandswomen whose combined careers span the past sixty years. Cornetist Martha (Martye) Jean Awkerman joined the U.S. Women in the Air Force (WAF) Band in 1955. She served the WAF band as cornet soloist and principal trumpet until the band was disbanded in 1961. In 1983, tubist Jan Duga joined…

Inculcating Quality Concepts in the US Air Force: Right Music, Wrong Step

DTIC Science & Technology

1994-04-01

CONCEPTS IN THE US AIR FORCE: RIGHT MUSIC , WRONG STEP Acceslon For NTIS CRA&J DTIC TAB Unannounced fJ by Justification Barbara A. Kucharczyk By. Lieutenant...TITLE: Inculcating Quality Concepts in the US Air Force: Right Music , Wrong Step AUTHOR: Barbara A. Kucharczyk, Lieutenant Colonel, USAF In its...perceived attitudinal backlash.4 While basic quality concepts are certainly the right music , many Air Force members are dancing the wrong step. Why? This

Air force Thunderbirds

NASA Image and Video Library

2007-02-01

Silhouetted against the cloud-strewn sky over NASA's Kennedy Space Center, a U.S. Air Force Thunderbird F-16D aircraft displays its prowess. The pilot is Maj. Tad Clark, who, after landing at the Shuttle Landing Facility, announced that Kennedy Space Center Visitor Complex will host the inaugural World Space Expo from Nov. 3 to 11, featuring an aerial salute by the Thunderbirds on its opening weekend. The Expo will create one of the largest displays of space artifacts, hardware and personalities ever assembled in one location with the objective to inspire, educate and engage the public by highlighting the achievements and benefits of space exploration.

An Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase Inhibitors.

PubMed

Xie, Huiding; Li, Yupeng; Yu, Fang; Xie, Xiaoguang; Qiu, Kaixiong; Fu, Jijun

2015-11-16

In the recent cancer treatment, B-Raf kinase is one of key targets. Nowadays, a group of imidazopyridines as B-Raf kinase inhibitors have been reported. In order to investigate the interaction between this group of inhibitors and B-Raf kinase, molecular docking, molecular dynamic (MD) simulation and binding free energy (ΔGbind) calculation were performed in this work. Molecular docking was carried out to identify the key residues in the binding site, and MD simulations were performed to determine the detail binding mode. The results obtained from MD simulation reveal that the binding site is stable during the MD simulations, and some hydrogen bonds (H-bonds) in MD simulations are different from H-bonds in the docking mode. Based on the obtained MD trajectories, ΔGbind was computed by using Molecular Mechanics Generalized Born Surface Area (MM-GBSA), and the obtained energies are consistent with the activities. An energetic analysis reveals that both electrostatic and van der Waals contributions are important to ΔGbind, and the unfavorable polar solvation contribution results in the instability of the inhibitor with the lowest activity. These results are expected to understand the binding between B-Raf and imidazopyridines and provide some useful information to design potential B-Raf inhibitors.

United States Air Force Child Care Center Infant Care Guide.

ERIC Educational Resources Information Center

Craig, Ardyn; And Others

Intended to guide Air Force infant caregivers in providing high quality group care for infants 6 weeks to 6 months of age, this infant care guide must be used in conjunction with other Air Force regulations on day care, such as AFR 215-1, Volume VI (to be renumbered AFR 215-27). After a brief introductory chapter (Chapter I), Chapter II indicates…

Enabling Air Force Satellite Ground System Automation Through Software Engineering

DTIC Science & Technology

US Air Force satellite ground stations require significant manpower to operate due to their fragmented legacy architectures . To improve operating...daily operations, but also the development, maintainability, and the extensibility of such systems. This thesis researches challenges to Air Force...satellite automation: 1) existing architecture of legacy systems, 2) space segment diversity, and 3) unclear definition and scoping of the term, automation

Combined RAF1 protein expression and p53 mutational status provides a strong predictor of cellular radiosensitivity

PubMed Central

Warenius, H M; Jones, M; Gorman, T; McLeish, R; Seabra, L; Barraclough, R; Rudland, P

2000-01-01

The tumour suppressor gene, p53, and genes coding for positive signal transduction factors can influence transit through cell-cycle checkpoints and modulate radiosensitivity. Here we examine the effects of RAF1 protein on the rate of exit from a G2/M block induced by γ-irradiation in relation to intrinsic cellular radiosensitivity in human cell lines expressing wild-type p53 (wtp53) protein as compared to mutant p53 (mutp53) protein. Cell lines which expressed mutp53 protein were all relatively radioresistant and exhibited no relationship between RAF1 protein and cellular radiosensitivity. Cell lines expressing wtp53 protein, however, showed a strong relationship between RAF1 protein levels and the radiosensitivity parameter SF2. In addition, when post-irradiation perturbation of G2/M transit was compared using the parameter T50 (time after the peak of G2/M delay at which 50% of the cells had exited from a block induced by 2 Gy of irradiation), RAF1 was related to T50 in wtp53, but not mutp53, cell lines. Cell lines which expressed wtp53 protein and high levels of RAF1 had shorter T50s and were also more radiosensitive. These results suggest a cooperative role for wtp53 and RAF1 protein in determining cellular radiosensitivity in human cells, which involves control of the G2/M checkpoint. © 2000 Cancer Research Campaign PMID:10993658

Beyond the Wild Blue Yonder: Creating an Air and Space Culture in Today’s Air Force

DTIC Science & Technology

1998-04-01

Organizational Change . 2nd ed. Westport, C.T.: Praeger Publishers, 1994. Estes III, Gen Howell M. “Air Force at a Crossroad” Speech, Air Force...American Military Styles in Strategy and Analysis. Baltimore: Johns Hopkins University Press, 1989. Conner, Patrick E., and Linda K. Lake. Managing

Development and Validation of the Air Force Cyber Intruder Alert Testbed (CIAT)

DTIC Science & Technology

2016-07-27

Validation of the Air Force Cyber Intruder Alert Testbed (CIAT) 5a. CONTRACT NUMBER FA8650-16-C-6722 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...network analysts. Therefore, a new cyber STE focused on network analysts called the Air Force Cyber Intruder Alert Testbed (CIAT) was developed. This...Prescribed by ANSI Std. Z39-18 Development and Validation of the Air Force Cyber Intruder Alert Testbed (CIAT) Gregory Funke, Gregory Dye, Brett Borghetti

Development of a novel class of B-RafV600E-selective inhibitors through virtual screening and hierarchical hit optimization

PubMed Central

Kong, Xiangqian; Qin, Jie; Li, Zeng; Vultur, Adina; Tong, Linjiang; Feng, Enguang; Rajan, Geena; Liu, Shien; Lu, Junyan; Liang, Zhongjie; Zheng, Mingyue; Zhu, Weiliang; Jiang, Hualiang; Herlyn, Meenhard; Liu, Hong; Marmorstein, Ronen; Luo, Cheng

2012-01-01

Oncogenic mutations in critical nodes of cellular signaling pathways have been associated with tumorigenesis and progression. The B-Raf protein kinase, a key hub in the canonical MAPK signaling cascade, is mutated in a broad range of human cancers and especially in malignant melanoma. The most prevalent B-RafV600E mutant exhibits elevated kinase activity and results in constitutive activation of the MAPK pathway, thus making it a promising drug target for cancer therapy. Herein, we described the development of novel B-RafV600E selective inhibitors via multi-step virtual screening and hierarchical hit optimization. Nine hit compounds with low micromolar IC50 values were identified as B-RafV600E inhibitors through virtual screening. Subsequent scaffold-based analogue searching and medicinal chemistry efforts significantly improved both the inhibitor potency and oncogene selectivity. In particular, compounds 22f and 22q possess nanomolar IC50 values with selectivity for B-RafV600E in vitro and exclusive cytotoxicity against B-RafV600E harboring cancer cells. PMID:22875039

Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization.

PubMed

Kong, Xiangqian; Qin, Jie; Li, Zeng; Vultur, Adina; Tong, Linjiang; Feng, Enguang; Rajan, Geena; Liu, Shien; Lu, Junyan; Liang, Zhongjie; Zheng, Mingyue; Zhu, Weiliang; Jiang, Hualiang; Herlyn, Meenhard; Liu, Hong; Marmorstein, Ronen; Luo, Cheng

2012-09-28

Oncogenic mutations in critical nodes of cellular signaling pathways have been associated with tumorigenesis and progression. The B-Raf protein kinase, a key hub in the canonical MAPK signaling cascade, is mutated in a broad range of human cancers and especially in malignant melanoma. The most prevalent B-Raf(V600E) mutant exhibits elevated kinase activity and results in constitutive activation of the MAPK pathway, thus making it a promising drug target for cancer therapy. Herein, we describe the development of novel B-Raf(V600E) selective inhibitors via multi-step virtual screening and hierarchical hit optimization. Nine hit compounds with low micromolar IC(50) values were identified as B-Raf(V600E) inhibitors through virtual screening. Subsequent scaffold-based analogue searching and medicinal chemistry efforts significantly improved both the inhibitor potency and oncogene selectivity. In particular, compounds 22f and 22q possess nanomolar IC(50) values with selectivity for B-Raf(V600E)in vitro and exclusive cytotoxicity against B-Raf(V600E) harboring cancer cells.

The US Air Force suicide prevention program: implications for public health policy.

PubMed

Knox, Kerry L; Pflanz, Steven; Talcott, Gerald W; Campise, Rick L; Lavigne, Jill E; Bajorska, Alina; Tu, Xin; Caine, Eric D

2010-12-01

We evaluated the effectiveness of the US Air Force Suicide Prevention Program (AFSPP) in reducing suicide, and we measured the extent to which air force installations implemented the program. We determined the AFSPP's impact on suicide rates in the air force by applying an intervention regression model to data from 1981 through 2008, providing 16 years of data before the program's 1997 launch and 11 years of data after launch. Also, we measured implementation of program components at 2 points in time: during a 2004 increase in suicide rates, and 2 years afterward. Suicide rates in the air force were significantly lower after the AFSPP was launched than before, except during 2004. We also determined that the program was being implemented less rigorously in 2004. The AFSPP effectively prevented suicides in the US Air Force. The long-term effectiveness of this program depends upon extensive implementation and effective monitoring of implementation. Suicides can be reduced through a multilayered, overlapping approach that encompasses key prevention domains and tracks implementation of program activities.

The US Air Force Suicide Prevention Program: Implications for Public Health Policy

PubMed Central

Pflanz, Steven; Talcott, Gerald W.; Campise, Rick L.; Lavigne, Jill E.; Bajorska, Alina; Tu, Xin; Caine, Eric D.

2010-01-01

Objectives. We evaluated the effectiveness of the US Air Force Suicide Prevention Program (AFSPP) in reducing suicide, and we measured the extent to which air force installations implemented the program. Methods. We determined the AFSPP's impact on suicide rates in the air force by applying an intervention regression model to data from 1981 through 2008, providing 16 years of data before the program's 1997 launch and 11 years of data after launch. Also, we measured implementation of program components at 2 points in time: during a 2004 increase in suicide rates, and 2 years afterward. Results. Suicide rates in the air force were significantly lower after the AFSPP was launched than before, except during 2004. We also determined that the program was being implemented less rigorously in 2004. Conclusions. The AFSPP effectively prevented suicides in the US Air Force. The long-term effectiveness of this program depends upon extensive implementation and effective monitoring of implementation. Suicides can be reduced through a multilayered, overlapping approach that encompasses key prevention domains and tracks implementation of program activities. PMID:20466973

Future Contracting for Availability

DTIC Science & Technology

2016-04-30

including Tornado and Harrier fast jets, and logistics activities related to aerial refueling. These cases outline the benefits achieved on these...platforms—including savings in the billions of pounds. Tornado and Harrier Aircraft Under the Tornado and Harrier programs, the Royal Air Force paid...owned K-707 and KDC-10 to refuel British Royal Air Force (RAF) GR-4A Tornadoes and Canadian Air Force CF-18s during training operations. Over the

77 FR 1913 - Notice of Meeting of the Agricultural Air Quality Task Force

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-12

... Conservation Service Notice of Meeting of the Agricultural Air Quality Task Force AGENCY: Natural Resources...), Agricultural Air Quality Task Force (AAQTF) will meet to continue discussions on critical air quality issues... relationship between agricultural production and air quality. The meeting is open to the public, and a draft...

Close Air Support and Interdiction Missions as Seen by the Air Force and Army

DTIC Science & Technology

1997-06-01

vehicle. Artillery Artillery is the surface weapon that typically causes the greatest destruction on the battlefield. Statistics from World War II show... Coursebook (USAF Air Command and Staff College, 1996), 628. 51. Dunnigan, 458. 52. Stephen Hosmer, Psychological Effects Of U.S. Air Operations In Four...Strategic Structures AY 96. Coursebook , vol. II. Maxwell Air Force Base, AL: 1995. Air War—Vietnam. New York, Arno Press, 1978. Atkinson, Rick

Military Retirement. Dream or Dilemma for Air Force Chaplains

DTIC Science & Technology

1983-02-01

DISTRIBUTION STATEMENT (of the abstract entered in Block 20, ii different Irom Report) I6. SUPPLEMENTARY NOTES 1S. KEY WORDS (Continue on reverse side...Chaplains by James W. Milisaps, Chaplain, Lt Col, USAF A RESEARCH REPORT SUBMITTED TO THE FACULTY IN FULFILLMENT OF THE RESEARCH seFo REQUIREMENT IY&’IC...TAR February 1983 IA ~.t.~ I -- w DEPARTMENT OF THE AIR FORCE MR WAR COLLEGE (ATC) MAXWELL AIR FORCE BASS, ALABAMA 26112 Office of the Dean School of

Profile of a Successful Civil Engineering Career in the United States Air Force.

DTIC Science & Technology

1984-09-01

Introduction ........ * * ........... 7 Career Success .. .. .. . .. . . ... 4- . .. ....... 8 Research Methods . .. . .. a.. . .. .. ............ it III...Definition of Terms I The following terms, for the purpose of this study, were defined as: Career success refers to an Air Force civil engineering officer...discussion of career success . An Air Force civil engineer is an officer currently possessing a 55XX duty Air Force . Specialty Code (AFSC). Statement of

Ground-water resources of Olmsted Air Force Base, Middletown, Pennsylvania

USGS Publications Warehouse

Meisler, Harold; Longwill, Stanley Miller

1961-01-01

Olmsted Air Force Base is underlain by the Gettysburg shale of Triassic age. The Gettysburg shale at the Air Force Base consists of interbedded red sandstone, siltstone, and shale. The average strike of the strata is N. 43° E., and the strata dip to the northwest at an average angle of 26°. The transmissibility of known aquifers in the warehouse area of the Air Force Base is low. Therefore, wells in the warehouse area have low specific capacities and yield only small supplies of water. Wells on the main base, however, yield relatively large supplies of water because the transmissibilities of the aquifers are relatively high. Pumping tests in the warehouse area and the eastern area of the main base indicated the presence of impermeable boundaries in both areas. Pumping tests in the central and western parts of the main base revealed that the Susquehanna River probably is acting as a source of recharge (forms a recharge boundary) for wells in those areas. Data obtained during this investigation indicate that additional supplies of ground water for Olmsted Air Force Base could best be obtained from the western part of the main base.

Commanding an Air Force Squadron

DTIC Science & Technology

1993-12-01

I The M ission ...................................... 3 The People ...................................... 5 The Chain of Command...of Air Force squadron commanders. By so doing, it serves as an explanatory text to allied officers, as a model for leadership studies, and as a...personnel, meeting the chain of command above him, and understanding the role of other units on the base. The Mission Lt Col John Bell, chief of the wing

Turnover Among Air Force Nurses.

DTIC Science & Technology

1987-03-01

Statistics. - The U. S. Air Force Institute of Technology, Civilian Institutions , Allied Health Branch, for their assistance and partial financial support...The University of Utah, Computer Center, for their financial support and use of computer equipment used in the statistical analysis. xiv The following...retain the nurses currently employed (Decker, et al., 19S2; Weisman, 1982). White (1980) concludes that nursina staff is a considerable [ financial

Air Force Institute of Technology, Civil Engineering School: Environmental Protection Course.

ERIC Educational Resources Information Center

Air Force Inst. of Tech., Wright-Patterson AFB, OH. School of Engineering.

This document contains information assembled by the Civil Engineering School to meet the initial requirements of NEPA 1969 and Executive Orders which required the Air Force to implement an effective environmental protection program. This course presents the various aspects of Air Force environmental protection problems which military personnel…

Environmental Assessment: Proposed Training Facilities, Hill Air Force Base, Utah

DTIC Science & Technology

2013-08-08

FA8201-09-D-0002 Facilities, Hill Air Force Base, Utah 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Klein, Randal 5d...PERFORMING ORGANIZATION REPORT NUMBER Streamline Consulting, LLC 1713 N. Sweetwater Lane Farmington, Utah 84025...proposes to construct new training facilities at Hill Air Force Base, Utah . The findings of this EA indicate that the proposed action would not have

United States Air Force Summer Research Program -- 1993. Volume 8. Phillips Laboratory

DTIC Science & Technology

1993-12-01

Research Program Phillips Laboratory Kirtland Air Force Base Albuquerque. New Mexico Sponsored by...Best Available Copy UNITED STATES AIR FORCE SUMMER RESEARCH PROGRAM -- 1993 SUMMER RESEARCH PROGRAM FINAL REPORTS VOLUME 8 PHILLIPS LABORATORY ...Alabama Box 870344 Tuscaloosa, AL 35487-0344 Final Report for: Graduate Student Research Program Phillips Laboratory , Hanscom AFB Sponsored by: Air

78 FR 32241 - U.S. Air Force Seeks Industry Input for National Security Space Launch Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... Security Space Launch Assessment AGENCY: Office of the Deputy Under Secretary of the Air Force for Space... that the United States Air Force, Office of the Deputy Under Secretary of the Air Force for Space.... Robert Long, 703-693-4978, Office of the Deputy Under Secretary of the Air Force for Space, 1670 Air...

United States Air Force Statistical Digest, Fiscal Year 1963, Eighteenth Edition

DTIC Science & Technology

1963-09-30

CAUSE FACTORS, WORLD-WI DE , BY QUARTER - FY 1963 (Includes United States Air Force, Air National Guard, Air Force Reserve, Military Air Transport ...DEFINITIONS. • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • 177 MILITARY AIR TRANSPORT Sf;RV.Cl;: (MATS) SELECTED TRANSPORT OPl!:R...SELECTED TR ...HSPORT OPERATIONS 0.. THE S,N- GLE MANAGER OP.RATING AOIII:~cY By ACTIVITY - FY 1963 ••••••• • • • • • 178 MIL.ITARV AIR TRANSPORT A,Rl..’P’T

Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf

PubMed Central

Jung, Sung Keun; Lee, Ki Won; Kim, Ho Young; Oh, Mi Hyun; Byun, Sanguine; Lim, Sung Hwan; Heo, Yong-Seok; Kang, Nam Joo; Bode, Ann M.; Dong, Zigang; Lee, Hyong Joo

2010-01-01

Chronic exposure to solar ultraviolet (UV) light causes skin photoaging. Many studies have shown that naturally occurring phytochemicals have anti-photoaging effects, but their direct target molecule(s) and mechanism(s) remain unclear. We found that myricetin, a major flavonoid in berries and red wine, inhibited wrinkle formation in mouse skin induced by chronic UVB irradiation (0.18 J/cm2, 3 days/wk for 15 wk). Myricetin treatment reduced UVB-induced epidermal thickening of mouse skin and also suppressed UVB-induced matrix metalloproteinase-9 (MMP-9) protein expression and enzyme activity. Myricetin appeared to exert its anti-aging effects by suppressing UVB-induced Raf kinase activity and subsequent attenuation of UVB-induced phosphorylation of MEK and ERK in mouse skin. In vitro and in vivo pull-down assays revealed that myricetin bound with Raf in an ATP-noncompetitive manner. Overall, these results indicate that myricetin exerts potent anti-photoaging activity by regulating MMP-9 expression through the suppression of Raf kinase activity. PMID:20093107

The "SWOT" of BRAF inhibition in melanoma: RAF inhibitors, MEK inhibitors or both?

PubMed

Nissan, Moriah H; Solit, David B

2011-12-01

Activating mutations in the BRAF gene are among the most prevalent kinase mutations in human cancer. BRAF mutations are most frequent in patients with melanoma where they occur in approximately 50% of patients with advanced disease. Remarkable clinical activity has recently been reported with highly selective RAF inhibitors in melanoma patients whose tumors harbor V600E BRAF mutations. The response rates of RAF inhibitors in patients with BRAF-mutant melanomas far exceed the activity level of any prior therapy studied in this disease. The results suggest that we have entered an era of personalized therapy for patients with metastatic melanoma in which treatment selection will be guided by BRAF mutational status. This review will discuss the strengths, weaknesses, opportunities and threats ("SWOT") of developing RAF and MEK selective inhibitors as anti-cancer therapies, recent insights into the mechanisms of intrinsic and acquired resistance to these agents, and current efforts to develop mechanism-based combination therapies.

Ras-sensitive IMP modulation of the Raf/MEK/ERK cascade through KSR1.

PubMed

Matheny, Sharon A; White, Michael A

2006-01-01

The E3 ubiquitin ligase IMP (impedes mitogenic signal propagation) was isolated as a novel Ras effector that negatively regulates ERK1/2 activation. Current evidence suggests that IMP limits the functional assembly of Raf/MEK complexes by inactivation of the KSR1 adaptor/scaffold protein. Interaction with Ras-GTP stimulates IMP autoubiquitination to relieve limitations on KSR function. The elevated sensitivity of IMP-depleted cells to ERK1/2 pathway activation suggests IMP acts as a signal threshold regulator by imposing reversible restrictions on the assembly of functional Raf/MEK/ERK kinase modules. These observations challenge commonly held concepts of signal transmission by Ras to the MAPK pathway and provide evidence for the role of amplitude modulation in tuning cellular responses to ERK1/2 pathway engagement. Here we describe details of the methods, including RNA interference, ubiquitin ligase assays, and protein complex analysis, that can be used to display the Ras-sensitive contribution of IMP to KSR-dependent modulation of the Raf/MEK/ERK pathway.

Environmental Assessment for Kirtland Air Force Base Prairie Dog Management Program

DTIC Science & Technology

2003-11-01

such as chicken and small pox and is characterized by rashes, temperature at or above 99.3 degrees, chills and/or sweats, headache, backache...FINDING OF NO SIGNIFICANT IMPACT PRAIRIE DOG MANAGEMENT PROGRAM AT KIRTLAND AIR FORCE BASE, NEW MEXICO The 377th Air Base Wing of Air Force Materiel...of African rodents, prairie dogs, and certain other animals. We are taking this action to prevent the spread of monkey pox , a communicable disease, in

77 FR 41165 - Notice of Meeting of the Agricultural Air Quality Task Force

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-12

... Agricultural Air Quality Task Force AGENCY: Natural Resources Conservation Service, USDA. ACTION: Notice of meeting. SUMMARY: The Department of Agriculture (USDA), Agricultural Air Quality Task Force (AAQTF) will.../Concerns Discussion Continued discussion of goals for Task Force Anaerobic Digester Technologies Odor...

Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.

PubMed

Granovsky, Alexey E; Clark, Matthew C; McElheny, Dan; Heil, Gary; Hong, Jia; Liu, Xuedong; Kim, Youngchang; Joachimiak, Grazyna; Joachimiak, Andrzej; Koide, Shohei; Rosner, Marsha Rich

2009-03-01

Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. Mutation of a conserved site (P74L) within the pocket leads to a loss or switch in the function of yeast or plant RKIP homologues. However, the mechanism by which the pocket influences RKIP function is unknown. Here we show that the pocket integrates two regulatory signals, phosphorylation and ligand binding, to control RKIP inhibition of Raf-1. RKIP association with Raf-1 is prevented by RKIP phosphorylation at S153. The P74L mutation increases kinase interaction and RKIP phosphorylation, enhancing Raf-1/MAPK signaling. Conversely, ligand binding to the RKIP pocket inhibits kinase interaction and RKIP phosphorylation by a noncompetitive mechanism. Additionally, ligand binding blocks RKIP association with Raf-1. Nuclear magnetic resonance studies reveal that the pocket is highly dynamic, rationalizing its capacity to interact with distinct partners and be involved in allosteric regulation. Our results show that RKIP uses a flexible pocket to integrate ligand binding- and phosphorylation-dependent interactions and to modulate the MAPK signaling pathway. This mechanism is an example of an emerging theme involving the regulation of signaling proteins and their interaction with effectors at the level of protein dynamics.

STS-67 landing at Edwards Air Force Base

NASA Technical Reports Server (NTRS)

1995-01-01

The Space Shuttle Endeavour, after completing a mission of almost 17 days duration in space, touches down on runway 22 at Edwards Air Force Base in southern California. Landing occurred at 1:46 p.m. (EST), March 18, 1995. In this photo the nose gear is still in the air as the orbiter touches down.

Separated from family, students chalk up their emotions > U.S. Air Force >

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

New urgent care pilot program for Prime beneficiaries > U.S. Air Force >

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

VCSAF, spouse take in Ramstein mission sets > U.S. Air Force > Article

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

Report on the Audit of the Use of Mobile Computers -- Air Force

DTIC Science & Technology

1991-02-15

We are providing this final report on the Audit of the Use of Mobile Computers--Air Force for your review and comments. The audit was conducted from...November 1989 through August 1990. The audit was part of our review of the use of mobile computers throughout DoD. Our overall objectives were to...operate, and maintain. The audit showed that the Air Force needed to retain no more than 5 of the 18 TSS’s. This would save the Air Force $27.3 million (Enclosure 2).

RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.

PubMed

Passariello, Catherine L; Martinez, Eliana C; Thakur, Hrishikesh; Cesareo, Maria; Li, Jinliang; Kapiloff, Michael S

2016-04-01

Noonan syndrome (NS) is a congenital disorder resulting from mutations of the Ras-Raf signaling pathway. Hypertrophic cardiomyopathy associated with RAF1 "RASopathy" mutations is a major risk factor for heart failure and death in NS and has been attributed to activation of MEK1/2-ERK1/2 mitogen-activated protein kinases. We recently discovered that type 3 p90 ribosomal S6 kinase (RSK3) is an ERK effector that is required, like ERK1/2, for concentric myocyte hypertrophy in response to pathological stress such as pressure overload. In order to test whether RSK3 also contributes to NS-associated hypertrophic cardiomyopathy, RSK3 knock-out mice were crossed with mice bearing the Raf1(L613V) human NS mutation. We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 was increased in Raf1(L613V) mice. Constitutive RSK3 gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice. These results are consistent with RSK3 being an important mediator of ERK1/2-dependent growth in RASopathy. In conjunction with previously published data showing that RSK3 is important for pathological remodeling of the heart, these data suggest that targeting of this downstream MAP-kinase pathway effector should be considered in the treatment of RASopathy-associated hypertrophic cardiomyopathy. Copyright © 2016 Elsevier Ltd. All rights reserved.

Institutional Memory and the US Air Force

DTIC Science & Technology

2016-01-01

38 | Air & Space Power Journal Institutional Memory and the US Air Force Lt Col Daniel J. Brown, USAF Disclaimer: The views and opinions expressed...national defense. After each ad- vance is tested in combat, a new round of intellectual sparring commences regarding Summer 2016 | 39 Institutional Memory ...the service’s institutional memory of how it fights and what it fights with—the ways and means of war fighting. Critical to maintaining its

AF presents fiscal year 2017 budget > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

B-52 Stratofortress joins coalition team > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

F-15s complete Hungarian deployment > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Goldfein nominated as 21st CSAF > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

F-22 inaugural deployment to Europe > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Range Environmental Assessment Overland Air Operations, Eglin Air Force Base, Florida

DTIC Science & Technology

2014-11-12

Level AICUZ Air Installation Compatible Use Zones ALANG Alabama Air National Guard ALARNG Alabama Army National Guard ASC Aeronautical Systems Center...7th Special Forces Group (Airborne) (7 SFG): x 2 − Alabama Air National Guard ( ALANG ): x 2 − Other Units: x 2 − 53rd Wing (53 WG): x 1.5...N&P 3 6 CH47 CH-47D 2 4 C23 HS748 1 2 U28A JPATS 2 4 CASA212 HS748 1 2 ALANG UH60 UH60A 4 8 Total for R-2915A 7575 14293 R-2915B AFSOC A10 A

75 FR 48929 - Notice of Meeting of the Agricultural Air Quality Task Force

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-12

... Agricultural Air Quality Task Force AGENCY: Natural Resources Conservation Service (NRCS), United States... Triangle Park, North Carolina 27711; (919) 541-5400. The Agricultural Air Quality Task Force (AAQTF) will meet to continue discussions on air quality issues relating to agriculture. Additionally, the Livestock...

AEROMEDICAL EVACUATION: CLINICALLY PREPARING AIR FORCE FLIGHT NURSES

DTIC Science & Technology

2016-10-10

AU/ACSC/2016 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY AEROMEDICAL EVACUATION: CLINICALLY PREPARING AIR FORCE FLIGHT NURSES by Michael...15 Figure 6: Patient Movement Visibility……………………………………………………..……16 Figure 7: Clinical Flight Nursing Qualification Criteria...treating each patient’s malady. Flight nurses ensure patients receive safe transport and are treated with dignity. For military members required

The B-Raf status of tumor cells may be a significant determinant of both antitumor and anti-angiogenic effects of pazopanib in xenograft tumor models.

PubMed

Gril, Brunilde; Palmieri, Diane; Qian, Yong; Anwar, Talha; Ileva, Lilia; Bernardo, Marcelino; Choyke, Peter; Liewehr, David J; Steinberg, Seth M; Steeg, Patricia S

2011-01-01

Pazopanib is an FDA approved Vascular Endothelial Growth Factor Receptor inhibitor. We previously reported that it also inhibits tumor cell B-Raf activity in an experimental brain metastatic setting. Here, we determine the effects of different B-Raf genotypes on pazopanib efficacy, in terms of primary tumor growth and anti-angiogenesis. A panel of seven human breast cancer and melanoma cell lines harboring different mutations in the Ras-Raf pathway was implanted orthotopically in mice, and tumor growth, ERK1/2, MEK1/2 and AKT activation, and blood vessel density and permeability were analyzed. Pazopanib was significantly inhibitory to xenografts expressing either exon 11 mutations of B-Raf, or HER2 activated wild type B-Raf; no significant inhibition of a xenograft expressing the common V600E B-Raf mutation was observed. Decreased pMEK staining in the responsive tumors confirmed that B-Raf was targeted by pazopanib. Interestingly, pazopanib inhibition of tumor cell B-Raf also correlated with its anti-angiogenic activity, as quantified by vessel density and area. In conclusion, using pazopanib, tumor B-Raf status was identified as a significant determinant of both tumor growth and angiogenesis.

The B-Raf Status of Tumor Cells May Be a Significant Determinant of Both Antitumor and Anti-Angiogenic Effects of Pazopanib in Xenograft Tumor Models

PubMed Central

Gril, Brunilde; Palmieri, Diane; Qian, Yong; Anwar, Talha; Ileva, Lilia; Bernardo, Marcelino; Choyke, Peter; Liewehr, David J.; Steinberg, Seth M.; Steeg, Patricia S.

2011-01-01

Pazopanib is an FDA approved Vascular Endothelial Growth Factor Receptor inhibitor. We previously reported that it also inhibits tumor cell B-Raf activity in an experimental brain metastatic setting. Here, we determine the effects of different B-Raf genotypes on pazopanib efficacy, in terms of primary tumor growth and anti-angiogenesis. A panel of seven human breast cancer and melanoma cell lines harboring different mutations in the Ras-Raf pathway was implanted orthotopically in mice, and tumor growth, ERK1/2, MEK1/2 and AKT activation, and blood vessel density and permeability were analyzed. Pazopanib was significantly inhibitory to xenografts expressing either exon 11 mutations of B-Raf, or HER2 activated wild type B-Raf; no significant inhibition of a xenograft expressing the common V600E B-Raf mutation was observed. Decreased pMEK staining in the responsive tumors confirmed that B-Raf was targeted by pazopanib. Interestingly, pazopanib inhibition of tumor cell B-Raf also correlated with its anti-angiogenic activity, as quantified by vessel density and area. In conclusion, using pazopanib, tumor B-Raf status was identified as a significant determinant of both tumor growth and angiogenesis. PMID:21998674

78 FR 10127 - Request for Nominations to the Agricultural Air Quality Task Force

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... Conservation Service Request for Nominations to the Agricultural Air Quality Task Force AGENCY: Natural... Nominations to the Agricultural Air Quality Task Force. SUMMARY: The Secretary of Agriculture invites... Force (AAQTF) which was established by the Federal Agriculture Improvement and Reform Act of 1996 to...

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.

PubMed

Ding, Zhijie; Lao, Yuanzhi; Zhang, Hong; Fu, Wenwei; Zhu, Lunlun; Tan, Hongsheng; Xu, Hongxi

2016-01-12

Metastasis causes a large number of deaths among esophageal cancer patients. The activation of RAF family proteins elevates tumor metastasis and proliferation. In screen targeting the RAF protein, we identified that Griffipavixanthone (GPX), a dimeric xanthone isolated from Garcinia esculenta, is a B-RAF and C-RAF inhibitor against esophageal cancer cells. Using wound healing, transwell migration and matrigel invasion assays, we confirmed that GPX significantly inhibited cell migration and invasion. Furthermore, exposure to GPX rendered cell proliferation and induced G2/M cell cycle arrest. Our mechanistic study showed that GPX suppressed cancer metastasis and proliferation through downregulation of RAF-MEK-ERK cascades proteins as well as RAF mRNA levels. In a pulmonary metastasis model, the intraperitoneal injection of GPX significantly suppressed esophageal tumor metastasis and ERK protein level in vivo. In conclusion, our present study suggested that GPX could inhibit tumor migration, invasion and proliferation in vitro and in vivo, which indicated the potential of GPX for preventing and treating esophageal cancer.

33 CFR 334.560 - Banana River at Patrick Air Force Base, Fla.; restricted area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Commander, 45th Space Wing, Patrick Air Force Base, Florida, and such agencies as he/she may designate. [29... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Banana River at Patrick Air Force... River at Patrick Air Force Base, Fla.; restricted area. (a) The area. The waters within an area...

33 CFR 334.560 - Banana River at Patrick Air Force Base, Fla.; restricted area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Commander, 45th Space Wing, Patrick Air Force Base, Florida, and such agencies as he/she may designate. [29... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Banana River at Patrick Air Force... River at Patrick Air Force Base, Fla.; restricted area. (a) The area. The waters within an area...

33 CFR 334.560 - Banana River at Patrick Air Force Base, Fla.; restricted area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Commander, 45th Space Wing, Patrick Air Force Base, Florida, and such agencies as he/she may designate. [29... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Banana River at Patrick Air Force... River at Patrick Air Force Base, Fla.; restricted area. (a) The area. The waters within an area...

33 CFR 334.560 - Banana River at Patrick Air Force Base, Fla.; restricted area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Commander, 45th Space Wing, Patrick Air Force Base, Florida, and such agencies as he/she may designate. [29... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Banana River at Patrick Air Force... River at Patrick Air Force Base, Fla.; restricted area. (a) The area. The waters within an area...

33 CFR 165.768 - Security Zone; MacDill Air Force Base, Tampa Bay, FL.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; MacDill Air Force....768 Security Zone; MacDill Air Force Base, Tampa Bay, FL. (a) Location. The following area is a... title. All waters within Tampa Bay, Florida in the vicinity of MacDill Air Force Base, including...

Communicating Why: Aligning the Air Force Message

DTIC Science & Technology

2015-02-17

innovation as the Air Force’s HOW, after all the service could not have demonstrated its WHY without it. For example, Lt Col Jimmy Doolittle ...the Doolittle Raid.54 Later in the war, General Doolittle’s first order as the newly appointed commander of the 8th Air Force was to free the...fighters from their strict bomber tether so they could go on the offensive against the German fighters.55 As Doolittle later noted, the German General of

U.S. Air Force Posture Statement 2000

DTIC Science & Technology

2000-01-01

quality of life for all Air Force members assigned to the headquarters. It will fo- cus on cutting costs, eliminating redun- dancies, reducing work of...of life initia- tives at the base level are essential. We re- alize that while we recruit individuals, we retain families . Especially with so many...power and constant vigilance. Our world-class people make it work — they will always be our first priority. We are an expedi- tionary aerospace force

Environmental Assessment for the Replacement of a Vehicle Wash Rack, Travis Air Force Base, California

DTIC Science & Technology

2005-04-01

meet state and U.S. Air Force (Air Force) environmental requirements for the use of cleaning products and washing systems; comply with Air Force and...and O/WSs • Use environmentally compliant cleaning products and wash systems • Be equipped with a credit card reader or similar device, to document... cleaning products and washing systems, including operating a covered O/WS within design capacity limits • Comply with Air Force and Department of

The United States Strategic Bombing Survey and Air Force Doctrine

DTIC Science & Technology

2001-06-01

a picture of Air Force doctrine after World War II. Published official Air Force doctrine is evaluated, but is not the sole source as it was tardy ...126. 21 Anderson’s Military Analysis Division had a similar response to the Naval Analysis Division’s report, The Philippines Campaign. Samples...of their response are shown below. Comment No. 2. This sentence concluded that the defeat in the Philippines campaign would constitute the final

Final Environmental Assessment: To Relocate Air Force Explosive Ordnance Disposal Administrative Complex at Eglin Air Force Base

DTIC Science & Technology

2006-10-01

Trips PM10E = .0022 * Trips COE = .262 * Trips Year 2010 and beyond: VOCE = .012 * Trips NOxE = .013 * Trips PM10E = .0022 * Trips COE...Air Force Base, Florida To convert from pounds per day to tons per year: VOC (tons/yr) = VOCE * DPYII/2000 NOx (tons/yr) = NOxE * DPYII/2000

Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner.

PubMed

De Vitis, Stefania; Sonia Treglia, Antonella; Ulianich, Luca; Turco, Stefano; Terrazzano, Giuseppe; Lombardi, Angela; Miele, Claudia; Garbi, Corrado; Beguinot, Francesco; Di Jeso, Bruno

2011-02-01

Activation of the Ras-Raf-extracellular signal-regulated kinase (ERK) pathway causes not only proliferation and suppression of apoptosis but also the antioncogenic response of senescence. How these contrasting effects are reconciled to achieve cell transformation and cancer formation is poorly understood. In a system of two-step carcinogenesis (dedifferentiated PC EIA, transformed PC EIA-polyoma-middle T [PC EIA + Py] and PC EIA-v-raf [PC EIA + raf] cells], v-raf cooperated with EIA by virtue of a strong prosurvival effect, not elicited by Py-middle T, evident toward serum-deprivation-and H(2)O(2)-induced apoptosis. Apoptosis was detected by DNA fragmentation and annexin V staining. The prosurvival function of v-raf was, in part, mitogen-activated protein kinase/ERK kinase (MEK)-dependent, as shown by pharmacological MEK inhibition. The MEK-dependent antiapoptotic effect of v-raf was exerted despite a lower level of P-ERK1/2 in EIA + raf cells with respect to EIA + Py/EIA cells, which was dependent on a high tyrosine phosphatase activity, as shown by orthovanadate blockade. An ERK1/2 tyrosine phosphatase was likely involved. The high tyrosine phosphatase activity was instrumental to the complete suppression of senescence, detected by β-galactosidase activity, because tyrosine phosphatase blockade induced senescence in EIA + raf but not in EIA + Py cells. High tyrosine phosphatase activity and evasion from senescence were confirmed in an anaplastic thyroid cancer cell line. Therefore, besides EIA, EIA + raf cells suppress senescence through a new mechanism, namely, phosphatase-mediated P-ERK1/2 inhibition, but, paradoxically, retain the oncogenic effects of the Raf-ERK pathway. We propose that the survival effect of Raf is not a function of absolute P-ERK1/2 levels at a given time but is rather dynamically dependent on greater variations after an apoptotic stimulus.

Air Force Academy Aeronautics Digest.

DTIC Science & Technology

1984-03-01

Farren, Glauert, R. H. Fowler , George Thomson, E . D. Adrian and Melvill Jones were certainly "Chudleighites." When I arrived at Farnborough I was put to... E . McCann, Lt. Colonel, USAF Director of Research, Studies, and Analysis UNCLASSIFIED SECURITY CLASSIFICATION OF TIlS PAGE REPORT DOCUMENTATION PAGE...NOS P ROGRAM PROJECT TASK WORK UNIT E LE MENT NO. NO. NO. NO * 11 TITLE fInclude Secuity Clawiaiciceton) Air Force Academy Aeronautics Digest

What It Takes. Air Force Command of Joint Operations

DTIC Science & Technology

2009-01-01

Iraq Assistance Group IDE intermediate developmental education IO international organization ISAF International Security and Assistance Force ISR...Operations Table A.1—Continued Joint Task Force Mission/Operation Start End Service Command Rank JTF–Joint Area Support Group (JASG) Iraqi Freedom...be of interest to a wide group of Air Force personnel involved in the development and func- tion of the service’s command organizations, including

A Sixty-Year Timeline of the Air Force Maui Optical and Supercomputing Site

DTIC Science & Technology

2013-01-01

19.3 million dollar contract to Contraves USA to build the AEOS 3.67-m telescope. Site Management Duffner, 2009 May 1992 The Air Force approves...system. Site Management Oder, undated Dec 18 1996 Contraves completes factory testing of AEOS telescope at its plant in Pennsylvania...States. Dec 13 1991 The Air Force awards a $19.3 million dollar contract to Contraves USA to build the AEOS 3.67-m telescope. May 1992 The Air Force

Tough Tommy’s Space Force: General Thomas S. Power and the Air Force Space Program

DTIC Science & Technology

2016-06-01

public release by AU Security and Policy Review Office. TOUGH TOMMY’S SPACE FORCE GENERAL THOMAS S . POWER AND THE AIR FORCE SPACE PROGRAM BY...in 2007, a Master of Operational Art and Science from the Air Command and Staff College in 2015, and a Doctorate in Economic Development from New...without a college diploma, and a relic of a bygone era of barnstormers perhaps high on courage but low on intelligence.8 In history, Power was a “sadist

Sections. March Air Force Base, Riverside, California, Combat Operations Center, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Sections. March Air Force Base, Riverside, California, Combat Operations Center, Combat Operations Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 14, approved March, 1962; specifications no. ENG-04-353-62-66; D.O. series AW 1596/15, Rev. "A"; file drawer 1290. Last revised 3 October 1966. Scale one-eighth inch to one foot. 30x36 inches. pencil on paper - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

Elevations. March Air Force Base, Riverside, California, Combat Operations Center, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Elevations. March Air Force Base, Riverside, California, Combat Operations Center, Combat Operations Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 14, approved March, 1962; specifications no. ENG-04-353-62-66; D.O. series AW 1596/14, Rev. "B"; file drawer 77-1/102. Last revised 3 October 1966. Scale one-eighth inch to one foot. 30x36 inches. photocopy on paper - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

Utility Building Plan, elevations and sections. March Air Force Base, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Utility Building Plan, elevations and sections. March Air Force Base, Riverside, California, COmbat Operations Center, Utility Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 57, approved March, 1962; specifications no. ENG-04-353-62-66; D.O. series AW 1596/57, Rev. "B"; file drawer 1290. Last revised 3 October 1966 "drawings updated." Various scales. 29 x 41 inches. pencil on paper - March Air Force Base, Strategic Air Command, Utility Building, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

Charting the Course for a New Air Force Inspection System

DTIC Science & Technology

2013-01-01

are down the hall from 3 All normative or prescriptive statements in this section reflect statements we heard from Air Force personnel. reducing the...in multiple forms. The responses we heard in the field tell us that the Air Force will achieve a better reception for MICT if its leadership first...primarily from the theory of High Reliability Organizations (HROs) pioneered by Karlene H. Roberts,9 whose work owed a great deal to the same body of

Characteristics of Child Sexual Abuse in the United States Air Force.

DTIC Science & Technology

1986-08-01

68 CHILD ABUSE IN MILITARY AND CIVILIAN COMMUNITIES ............................. 72 SUMMARY AND DISCUSSION OF IMPLICATIONS OF THE LITERATURE...AND CHILD SEXUAL ABUSE IN THE AIR FORCE ............... 86 LABELING THEORY ........................... 87 CHILD ABUSE AND THE LABELING PERSPECTIVE...and, case status) of the reports of child sexual abuse made to the Family Advocacy Program (the Air Force’s program for dealing with child abuse --this

Air Force FY 2000 Financial Reporting of Operating Materials and Supplies

DTIC Science & Technology

2001-07-05

AIR FORCE FY 2000 FINANCIAL REPORTING OF OPERATING MATERIALS AND SUPPLIES Report No. D-2001-156 July 5...Covered (from... to) ("DD MON YYYY") Title and Subtitle Air Force FY 2000 Financial Reporting of Operating Materials and Supplies Contract or Grant...munitions assets. Objectives. The overall audit objective was to obtain information on the financial reporting of operating materials and supplies

Raf Kinase Inhibitory Protein Function Is Regulated via a Flexible Pocket and Novel Phosphorylation-Dependent Mechanism▿ †

PubMed Central

Granovsky, Alexey E.; Clark, Matthew C.; McElheny, Dan; Heil, Gary; Hong, Jia; Liu, Xuedong; Kim, Youngchang; Joachimiak, Grazyna; Joachimiak, Andrzej; Koide, Shohei; Rosner, Marsha Rich

2009-01-01

Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. Mutation of a conserved site (P74L) within the pocket leads to a loss or switch in the function of yeast or plant RKIP homologues. However, the mechanism by which the pocket influences RKIP function is unknown. Here we show that the pocket integrates two regulatory signals, phosphorylation and ligand binding, to control RKIP inhibition of Raf-1. RKIP association with Raf-1 is prevented by RKIP phosphorylation at S153. The P74L mutation increases kinase interaction and RKIP phosphorylation, enhancing Raf-1/MAPK signaling. Conversely, ligand binding to the RKIP pocket inhibits kinase interaction and RKIP phosphorylation by a noncompetitive mechanism. Additionally, ligand binding blocks RKIP association with Raf-1. Nuclear magnetic resonance studies reveal that the pocket is highly dynamic, rationalizing its capacity to interact with distinct partners and be involved in allosteric regulation. Our results show that RKIP uses a flexible pocket to integrate ligand binding- and phosphorylation-dependent interactions and to modulate the MAPK signaling pathway. This mechanism is an example of an emerging theme involving the regulation of signaling proteins and their interaction with effectors at the level of protein dynamics. PMID:19103740

Methodology for Constructing a Modernization Roadmap for Air Force Automatic Test Systems

DTIC Science & Technology

2012-01-01

Constructing a Modernization Roadmap for Air Force Automatic Test Systems Lionel A. Galway , Rachel Rue, James M. Masters, Ben D. Van Roo, Manuel...constructing a modernization roadmap for Air Force automatic test systems / Lionel A. Galway ... [et al.]. p. cm. Includes bibliographical...references. ISBN 978-0-8330-5899-7 (pbk. : alk. paper) 1. United States. Air Force—Weapons systems—Testing. I. Galway , Lionel A., 1950- UG633.M3445

Rescuing Joint Personnel Recovery: Using Air Force Capability to Address Joint Shortfalls

DTIC Science & Technology

2011-06-01

of an IP, the IP is not successfully reintegrated or the lessons learned are not incorporated into other operations. Adversaries will benefit from...Washington, D.C.: Office of Air Force History , United States Air Force, 1980, 117. 47 Durant , Michael J. In the Company of Heroes, Penguin Group... Lessons Learned, 22 September 2005, 3. 2 US Joint Task Force Katrina. The Federal Response to Hurricane Katrina Lessons Learned, February 2006, 54

75 FR 22560 - Federal Advisory Committee; U.S. Air Force Scientific Advisory Board; Charter Renewal

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... Chairperson. In addition, the Secretary of the Air Force may appoint, as deemed necessary non-voting... provided to the membership for their consideration. Contact information for the U.S. Air Force Scientific... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; U.S. Air Force...

Genetic Validation of Cell Proliferation via Ras-Independent Activation of the Raf/Mek/Erk Pathway.

PubMed

Lechuga, Carmen G; Simón-Carrasco, Lucía; Jacob, Harrys K C; Drosten, Matthias

2017-01-01

Signaling transmitted by the Ras family of small GTPases (H-, N-, and K-Ras) is essential for proliferation of mouse embryonic fibroblasts (MEFs). However, constitutive activation of the downstream Raf/Mek/Erk pathway can bypass the requirement for Ras proteins and allow cells to proliferate in the absence of the three Ras isoforms. Here we describe a protocol for a colony formation assay that permits evaluating the role of candidate proteins that are positive or negative regulators of cell proliferation mediated via Ras-independent Raf/Mek/Erk pathway activation. K-Ras lox (H-Ras -/- , N-Ras -/- , K-Ras lox/lox , RERT ert/ert ) MEFs are infected with retro- or lentiviral vectors expressing wild-type or constitutively activated candidate cDNAs, shRNAs, or sgRNAs in combination with Cas9 to ascertain the possibility of candidate proteins to function either as an activator or inhibitor of Ras-independent Raf/Mek/Erk activation. These cells are then seeded in the absence or presence of 4-Hydroxytamoxifen (4-OHT), which activates the resident CreERT2 alleles resulting in elimination of the conditional K-Ras alleles and ultimately generating Rasless cells. Colony formation in the presence of 4-OHT indicates cell proliferation via Ras-independent Raf/Mek/Erk activation.

Forced-air warming design: evaluation of intake filtration, internal microbial buildup, and airborne-contamination emissions.

PubMed

Reed, Mike; Kimberger, Oliver; McGovern, Paul D; Albrecht, Mark C

2013-08-01

Forced-air warming devices are effective for the prevention of surgical hypothermia. However, these devices intake nonsterile floor-level air, and it is unknown whether they have adequate filtration measures to prevent the internal buildup or emission of microbial contaminants. We rated the intake filtration efficiency of a popular current-generation forced-air warming device (Bair Hugger model 750, Arizant Healthcare) using a monodisperse sodium chloride aerosol in the laboratory. We further sampled 23 forced-air warming devices (same model) in daily hospital use for internal microbial buildup and airborne-contamination emissions via swabbing and particle counting. Laboratory testing found the intake filter to be 63.8% efficient. Swabbing detected microorganisms within 100% of the forced-air warming blowers sampled, with isolates of coagulase-negative staphylococci, mold, and micrococci identified. Particle counting showed 96% of forced-air warming blowers to be emitting significant levels of internally generated airborne contaminants out of the hose end. These findings highlight the need for upgraded intake filtration, preferably high-efficiency particulate air filtration (99.97% efficient), on current-generation forced-air warming devices to reduce contamination buildup and emission risks.

Force Structure: Better Information Needed to Support Air Force A-10 and Other Future Divestment Decisions

DTIC Science & Technology

2016-08-01

estimate should have a standardized structure that breaks costs into discrete elements with sufficient detail to ensure that cost elements are...FORCE STRUCTURE Better Information Needed to Support Air Force A-10 and Other Future Divestment Decisions Report...Accountability Office Highlights of GAO-16-816, a report to congressional committees August 2016 FORCE STRUCTURE Better Information Needed to Support

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.

PubMed

Filchtinski, Daniel; Sharabi, Oz; Rüppel, Alma; Vetter, Ingrid R; Herrmann, Christian; Shifman, Julia M

2010-06-11

Ras is a small GTP-binding protein that is an essential molecular switch for a wide variety of signaling pathways including the control of cell proliferation, cell cycle progression and apoptosis. In the GTP-bound state, Ras can interact with its effectors, triggering various signaling cascades in the cell. In the GDP-bound state, Ras looses its ability to bind to known effectors. The interaction of the GTP-bound Ras (Ras(GTP)) with its effectors has been studied intensively. However, very little is known about the much weaker interaction between the GDP-bound Ras (Ras(GDP)) and Ras effectors. We investigated the factors underlying the nucleotide-dependent differences in Ras interactions with one of its effectors, Raf kinase. Using computational protein design, we generated mutants of the Ras-binding domain of Raf kinase (Raf) that stabilize the complex with Ras(GDP). Most of our designed mutations narrow the gap between the affinity of Raf for Ras(GTP) and Ras(GDP), producing the desired shift in binding specificity towards Ras(GDP). A combination of our best designed mutation, N71R, with another mutation, A85K, yielded a Raf mutant with a 100-fold improvement in affinity towards Ras(GDP). The Raf A85K and Raf N71R/A85K mutants were used to obtain the first high-resolution structures of Ras(GDP) bound to its effector. Surprisingly, these structures reveal that the loop on Ras previously termed the switch I region in the Ras(GDP).Raf mutant complex is found in a conformation similar to that of Ras(GTP) and not Ras(GDP). Moreover, the structures indicate an increased mobility of the switch I region. This greater flexibility compared to the same loop in Ras(GTP) is likely to explain the natural low affinity of Raf and other Ras effectors to Ras(GDP). Our findings demonstrate that an accurate balance between a rigid, high-affinity conformation and conformational flexibility is required to create an efficient and stringent molecular switch. Copyright 2010 Elsevier Ltd

Environmental Assessment for Implementation of the Schriever Air Force Base Integrated Natural Resources Management Plan

DTIC Science & Technology

2008-03-01

Force Policy Directive (AFPD) 32-70, Environmental Quality ( July 20, 1994); and Air Force Instruction (AFI) 32-7064, Integrated Natural Resources...Environmental Conservation Program; Air Force Policy Directive (AFPD) 32-70, Environmental Quality ( July 20, 1994); and Air Force Instruction (AFI...thunderstorms occur in the late spring to summer months along the Front Range and can result in flash flood conditions (greatest potential in July and August

Developing a Model for Assigning Senior Officers in the Brazilian Air Force

DTIC Science & Technology

2015-03-01

Federativa do Brasil 2014)................................................... 3 Figure 2. Distribution of senior officers by specialty (after Presidente da...República Federativa do Brasil 2014)................................................... 4 Figure 3. Simplified layout of the Brazilian Air Force...Specialties and ranks in the Brazilian Air Force (after Presidente da República Federativa do Brasil 2014

32 CFR 644.327 - Air Force military real property.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Air Force military real property. 644.327 Section 644.327 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Procedure for Placing Real Property in Excess Status § 644.327 Air...

Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton.

PubMed

Yang, Lifeng; Tang, Lian; Dai, Fan; Meng, Guoliang; Yin, Runting; Xu, Xiaole; Yao, Wenjuan

2017-08-15

Both RhoA/ROCK and Raf-1/CK2 pathway play essential roles in cell proliferation, apoptosis, differentiation, and multiple other common cellular functions. We previously reported that vimentin is responsible for TNF-α-induced cell apoptosis. Herein, we investigated the regulation of RhoA/ROCK and Raf-1/CK2 signaling on vimentin filaments and endothelial apoptosis mediated by TNF-α. Treatment with TNF-α significantly induced the activation of RhoA and ROCK, and the expression of ROCK1. RhoA deficiency could obviously inhibit ROCK activation and ROCK1 expression induced by TNF-α. Both RhoA deficiency and ROCK activity inhibition (Y-27632) greatly inhibited endothelial apoptosis and preserved cell viability in TNF-α-induced human umbilical vein endothelial cells (HUVECs). Also vimentin phosphorylation and the remodeling of vimentin or phospho-vimentin induced by TNF-α were obviously attenuated by RhoA suppression and ROCK inhibition. TNF-α-mediated vimentin cleavage was significantly inhibited by RhoA suppression and ROCK inhibition through decreasing the activation of caspase3 and 8. Furthermore, TNF-α treatment greatly enhanced the activation of Raf-1. Suppression of Raf-1 or CK2 by its inhibitor (GW5074 or TBB) blocked vimentin phosphorylation, remodeling and endothelial apoptosis, and preserved cell viability in TNF-α-induced HUVECs. However, Raf-1 inhibition showed no significant effect on TNF-α-induced ROCK expression and activation, suggesting that the regulation of Raf-1/CK2 signaling on vimentin was independent of ROCK. Taken together, these results indicate that both RhoA/ROCK and Raf-1/CK2 pathway are responsible for TNF-α-mediated endothelial cytotoxicity via regulating vimentin cytoskeleton. Copyright © 2017 Elsevier B.V. All rights reserved.

A Historical Analysis of Basic Air Force Doctrine Education within the United States States Air Force Air Command and Staff College, 1947-1987.

DTIC Science & Technology

1987-09-01

doctrine, especially joint doctrine. Because of this we make mistakes. I believe that the Air Force needs to develop a formal doctrinallo education...jresenteo arguments for all three points of view, but ne was particularly critical of tne educacional system within tae United States military. He said tnat

Air Force Training: Further Analysis and Planning Needed to Improve Effectiveness

DTIC Science & Technology

2016-09-01

training, and (3) established virtual training plans that include desirable characteristics of a comprehensive strategy. GAO reviewed Air Force training...requirements may not reflect current and emerging training needs, because the Air Force has not comprehensively reassessed the assumptions underlying them...include all desirable characteristics of a comprehensive strategy, such as a risk-based investment strategy or a time line for addressing training needs

Flextime: A Modified Work Force Scheduling Technique for Selected Headquarters Air Force Logistics Command Organizations.

ERIC Educational Resources Information Center

Kimzey, Reed T.; Prince, Samuel M. O.

The thesis discusses the advantages and disadvantages of one work force scheduling technique--flextime. The authors were interested in determining if a flextime schedule could be put into effect in a governmental organization such as Headquarters Air Force Logistics Command (AFLC). The study objectives were to determine the feasibility,…

78 FR 59343 - Meeting of the National Commission on the Structure of the Air Force

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... of the Air Force AGENCY: Director of Administration and Management, DoD. ACTION: Notice of Advisory... following Federal Advisory Committee meeting of the National Commission on the Structure of the Air Force... Commission on the Structure of the Air Force, 1950 Defense Pentagon, Room 3A874, Washington, DC 20301-1950...

KC-46 team wins DOD environmental award > U.S. Air Force > Article Display

Science.gov Websites

Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games Portraits in Courage

Ground-water hydrology and water quality of the southern high plains aquifer, Melrose Air Force Range, Cannon Air Force Base, Curry and Roosevelt Counties, New Mexico, 2002-03

USGS Publications Warehouse

Langman, Jeff B.; Gebhardt, Fredrick E.; Falk, Sarah E.

2004-01-01

In cooperation with the U.S. Air Force, the U.S. Geological Survey characterized the ground-water hydrology and water quality at Melrose Air Force Range in east-central New Mexico. The purpose of the study was to provide baseline data to Cannon Air Force Base resource managers to make informed decisions concerning actions that may affect the ground-water system. Five periods of water-level measurements and four periods of water-quality sample collection were completed at Melrose Air Force Range during 2002 and 2003. The water-level measurements and water-quality samples were collected from a 29-well monitoring network that included wells in the Impact Area and leased lands of Melrose Air Force Range managed by Cannon Air Force Base personnel. The purpose of this report is to provide a broad overview of ground-water flow and ground-water quality in the Southern High Plains aquifer in the Ogallala Formation at Melrose Air Force Range. Results of the ground-water characterization of the Southern High Plains aquifer indicated a local flow system in the unconfined aquifer flowing northeastward from a topographic high, the Mesa (located in the southwestern part of the Range), toward a regional flow system in the unconfined aquifer that flows southeastward through the Portales Valley. Ground water was less than 55 years old across the Range; ground water was younger (less than 25 years) near the Mesa and ephemeral channels and older (25 years to 55 years) in the Portales Valley. Results of water-quality analysis indicated three areas of different water types: near the Mesa and ephemeral channels, in the Impact Area of the Range, and in the Portales Valley. Within the Southern High Plains aquifer, a sodium/chloride-dominated ground water was found in the center of the Impact Area of the Range with water-quality characteristics similar to ground water from the underlying Chinle Formation. This sodium/chloride-dominated ground water of the unconfined aquifer in the Impact

An Air Force Strategic Vision for 2020-2030

DTIC Science & Technology

2011-01-01

General Corley about the Future of Air Power,” Second Line of Defense, August 2010, http:// www.sldinfo.com/? p =11608. 14. Dahm, Report on Technology...Publication Series, 2001); Alberts, J. J. Garstka, and F. P . Stein, Network Centric Warfare: Develop- ing and Leveraging Information Superiority (Washington...2005), 217–30. 38. See Jennifer D. P . Moroney et al., International Cooperation with Partner Air Forces (Washington: Rand Publishing, 2009), 9

Facilities and the Air Force Systems Acquisition Process.

DTIC Science & Technology

1985-05-01

INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION (it applicable) Sc. ADDRESS (City. State and ZIP Code) 10. SOURCE OF FUNDING NOS. PROGRAM PROJECT TASK WORK UNIT...L- . - - - CHAP T-F< I P f),DUCTr JOti The Air Force is in the midst of its most extensive peacetime force modernization programs ...will answer the following ques- tions: a. Are facility requirements anticipated and ade- quatel% scoped during the early phase of program development so

Air Force Strategic Planning: Past, Present, and Future

DTIC Science & Technology

2017-01-01

understanding the policy environment; encouraging ideas from the bottom; starting the strategy from the top; keeping the message succinct, substantive, and...Force became a separate and equal service, it developed a reputation for innovative thinking. Starting in the aftermath of World War I, American...least long-range programmatic planning and resource allocation) proved fortuitous. Starting in the early 1980s, the Air Force also needed to plan how

NPDES Permit for Cheyenne Mountain Air Force Station in Colorado

EPA Pesticide Factsheets

Under NPDES permit CO-0034762, the Cheyenne Mountain Air Force Station is authorized to discharge from the interior storm drainage system and air exhaust stacks at the Cheyenne Mountain Complex in El Paso County, Colorado, to tributaries Fountain Creek.

Environmental Assessment for the Air Force Research Laboratory Security Fence Project, Edwards Air Force Base, California

DTIC Science & Technology

2012-11-26

Pleistocene/Early-Holocene Prehistory (12,000 to 7,000 BP). The Lake Mojave Period in the southwestern Great Basin comprises a regional manifestation...adaptive patterns with focal exploitation of such habitats (Tetra Tech 2010). Middle-Holocene Prehistory (8,000 to 4,000 BP). Succeeding Lake Mojave in the...Security Fence at Edwards Air Force Base, California Late Holocene Prehistory (4,000 to Contact). With return to more “favorable” environmental

Forced air heat sink apparatus

NASA Technical Reports Server (NTRS)

Rippel, Wally E. (Inventor)

1989-01-01

A high efficiency forced air heat sink assembly employs a split feed transverse flow configuration to minimize the length of the air flow path through at least two separated fin structures. Different embodiments use different fin structure material configurations including honeycomb, corrugated and serpentine. Each such embodiment uses a thermally conductive plate having opposed exterior surfaces; one for receiving a component to be cooled and one for receiving the fin structures. The serpentine structured fin embodiment employs a plurality of fin supports extending from the plate and forming a plurality of channels for receiving the fin structures. A high thermal conductivity bondant, such as metal-filled epoxy, may be used to bond the fin structures to either the plate or the fin supports. Dip brazing and soldering may also be employed depending upon the materials selected.

Air Force Command and Control: The Path Ahead. Volume 1: Summary

DTIC Science & Technology

2000-12-01

benefits of an integrated approach to implementation. The organization, management, and process are not in place to carry out the evolution in...critical support for successful EAF operations. 9 Air Force Space Operations Center (AFSPACE) AOC. The 14th Air Force AFSPACE AOC is an in- place ...right times and places , so that they can pass consistent data that convert to shared understanding, ultimately producing cooperative decision making

76 FR 52932 - Notice of Meeting of the Agricultural Air Quality Task Force

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

... DEPARTMENT OF AGRICULTURE Natural Resources Conservation Service Notice of Meeting of the Agricultural Air Quality Task Force AGENCY: Natural Resources Conservation Service (NRCS). ACTION: Notice of meeting. SUMMARY: The Agricultural Air Quality Task Force (AAQTF) will meet to continue discussions on...

Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.

PubMed

Dritschilo, Anatoly; Huang, Chao H; Rudin, Charles M; Marshall, John; Collins, Brian; Dul, Jeanne L; Zhang, Chuanbo; Kumar, Deepak; Gokhale, Prafulla C; Ahmad, Ateeq; Ahmad, Imran; Sherman, Jeffrey W; Kasid, Usha N

2006-02-15

Raf proteins are key elements of growth-related cellular signaling pathways and are a component of cancer cell resistance to radiation therapy. Antisense oligonucleotides to c-raf-1 permit highly selective inhibition of the gene product and offer a strategy for sensitizing cancer cells to radiation therapy. In this dose escalation study, we evaluated the safety of combined liposomal formulation of raf antisense oligonucleotide (LErafAON) and radiation therapy in patients with advanced malignancies. Patients with advanced solid tumors were treated with LErafAON in a phase I dose escalation study while receiving palliative radiation therapy. Drug-related and radiation-related toxicities were monitored. Pharmacokinetics and expression of c-raf-1 mRNA and Raf-1 protein were determined in peripheral blood mononuclear cells. Seventeen patients with palliative indications for radiation therapy were entered into this study. Thirteen patients received daily infusions of LErafAON and four received twice-weekly infusions. Radiation therapy was delivered in daily 300-cGy fractions over 2 weeks. Patients tolerated radiation, and no unexpected radiation-related side effects were observed. Drug-related reactions (grade > or =2), such as back pain, chills, dyspnea, fatigue, fever, flushing, and hypertension, were observed in most patients and were managed by premedication with corticosteroids and antihistamines. Serious adverse events occurred in five patients, including acute infusion-related symptoms, abnormal liver function tests, hypoxia, dehydration, diarrhea, esophagitis, fever, hypokalemia, pharyngitis, and tachypnea. Twelve of 17 patients were evaluable for tumor response at completion of treatment; four showed partial response, four showed stable disease, and four experienced progressive disease. The intact rafAON was detected in plasma for 30 minutes to several hours. Six patients with partial response or stable disease were evaluable for c-raf-1 mRNA and/or Raf-1

Training augmentation device for the Air Force satellite Control Network

NASA Technical Reports Server (NTRS)

Shoates, Keith B.

1993-01-01

From the 1960's and into the early 1980's satellite operations and control were conducted by Air Force Systems Command (AFSC), now Air Force Materiel Command (AFMC), out of the Satellite Control Facility at Onizuka AFB, CA. AFSC was responsible for acquiring satellite command and control systems and conducting routine satellite operations. The daily operations, consisting of satellite health and status contacts and station keeping activities, were performed for AFSC by a Mission Control Team (MCT) staffed by civilian contractors who were responsible for providing their own technically 'qualified' personnel as satellite operators. An MCT consists of five positions: mission planner, ground controller, planner analyst, orbit analyst, and ranger controller. Most of the training consisted of On-the-Job-Training (OJT) with junior personnel apprenticed to senior personnel until they could demonstrate job proficiency. With most of the satellite operators having 15 to 25 years of experience, there was minimal risk to the mission. In the mid 1980's Air Force Space Command (AFSPACOM) assumed operational responsibility for a newly established control node at Falcon AFB (FAFB) in CO. The satellites and ground system program offices (SPO's) are organized under AFSC's Space and Missiles Systems Center (SMC) to function as a systems engineering and acquisition agency for AFSPACECOM. The collection of the satellite control nodes, ground tracking stations, computer processing equipment, and connecting communications links is referred to as the Air Force Satellite Control Network (AFSCN).

Rand Project AIR FORCE Annual Report 2010

DTIC Science & Technology

2010-01-01

LLC Michael Lynton, Chairman and Chief Executive Officer, Sony Pictures Entertainment Ronald L. Olson, Partner, Munger, Tolles & Olson LLP Paul H...management, and his Air Force career centered on research. Even a shared love of music finds them in different parts of the orchestra, with Ray as a

Considering the Audience: Air Force Recruiting Presentations

ERIC Educational Resources Information Center

Malone, Darek L.

2012-01-01

Each Air Force recruiter is formally trained in public speaking and the art of salesmanship or persuasion. These recruiters communicate to thousands of high school students each year through presentations in classrooms, auditoriums and other venues as part of their assigned duties. Persuasive presentations are public speaking events specifically…

Air pollution radiative forcing from specific emissions sectors at 2030

NASA Astrophysics Data System (ADS)

Unger, Nadine; Shindell, Drew T.; Koch, Dorothy M.; Streets, David G.

2008-01-01

Reduction of short-lived air pollutants can contribute to mitigate global warming in the near-term with ancillary benefits to human health. However, the radiative forcings of short-lived air pollutants depend on the location and source type of the precursor emissions. We apply the Goddard Institute for Space Studies atmospheric composition-climate model to quantify near-future (2030 A1B) global annual mean radiative forcing by ozone (O3) and sulfate from six emissions sectors in seven geographic regions. At 2030 the net forcings from O3, sulfate, black and organic carbon, and indirect CH4 effects for each emission sector are (in mWm-2) biomass burning, +95; domestic, +68; transportation, +67; industry, -131; and power, -224. Biomass burning emissions in East Asia and central and southern Africa, domestic biofuel emissions in East Asia, south Asia, and central and southern Africa, and transportation emissions in Europe and North America have large net positive forcings and are therefore attractive targets to counter global warming. Power and industry emissions from East Asia, south Asia, and north Africa and the Middle East have large net negative forcings. Therefore air quality control measures that affect these regional sectors require offsetting climate measures to avoid a warming impact. Linear relationships exist between O3 forcing and biomass burning and domestic biofuel CO precursor emissions independent of region with sensitivity of +0.2 mWm-2/TgCO. Similarly, linear relationships exist between sulfate forcing and SO2 precursor emissions that depend upon region but are independent of sector with sensitivities ranging from -3 to -12 mWm-2/TgS.

Strapping in and Bailing out: Navy and Air Force Joint Acquisition of Aircraft

DTIC Science & Technology

2002-06-01

Secretary of the Air Force and the Secretary of Defense were not pleased with the attempted shenanigans . With the rarely invoked contractor review...December 14, 1990. Tarascio, Colonel John R., Director of Budget & Appropriations Liaison, Assistant Secretary of the Air Force ( Financial Management

Support Air and Space Expeditionary Forces. Analysis of Combat Support Basing Options

DTIC Science & Technology

2004-01-01

Mahyar A . Amouzegar, Robert S. Tripp, Ronald G. McGarve Edward W Chan C. Robert Roll, Jr. _77 Ap L_ L; Reý PROJECT AIR FORCE - Supporting Air and Space...Expeditionary Forces Analysis of Combat Support Basing Options Mahyar A . Amouzegar Robert S. Tripp Ronald G. McGarvey Edward W. Chan C. Robert Roll...support basing options / Mahyar A . Amouzegar ... [et al. p. cm. "’MG-261." Indudes bibliographical references. ISBN 0-8330-3675-0 (pbk.) 1. Air bases

Final Environmental Assessment: For Construction of a Security Forces Complex on Eglin Air Force Base, FL

DTIC Science & Technology

2005-05-01

form of weapons cleaning products and wastes. State of Florida and Air Force regulations have been implemented 05/31/05 Final Environmental Assessment...Forces Complex will generate hazardous materials in the form of weapons cleaning products and wastes. Break-Free CLP Liquid is a cleaner, lubricant

The United States Air Force Academy: A Bibliography: 1968 - 1972

DTIC Science & Technology

1972-09-01

Hist - Aerospace Historian Aero Med - Aerospace Medicine Air Reservist Airman America Armed Forces Compt - Armed Forces Comptroller Armed Forces J...center for aviary medicine . Airman 15:48, May 1971. 235 Jeans, Kit. Children learn at Academy school--CHAP pro- gram. AF Times 30:26, 29 Apr...Indoctrination 10355 Merit lists 10356 Organization 10330 Wing strength 10354 Marihuana incidents 10912 Marriage of cadet 10326

The Air Force Officer Qualifying Test: Validity, Fairness, and Bias. Technical Report

ERIC Educational Resources Information Center

Hardison, Chaitra M.; Sims, Carra S.; Wong, Eunice C.

2010-01-01

The Air Force has long recognized the importance of selecting the most qualified officers possible. For more than 60 years, it has relied on the Air Force Officer Qualifying Test (AFOQT) as one measure of those qualifications. A variety of concerns have been raised about whether the AFOQT is biased, too expensive, or even valid for predicting…

Air Force Groundwater Contamination Cleanup: An Evaluation of the Pump- and-Treat Method.

DTIC Science & Technology

1988-09-01

Other contaminants commonly detected at Air Force installations are benzene, mercury , pesticides, polychlori- nated biphenyls (PCBs), and Toxaphene...the air base experienced a 3000 gallon fuel (JP-4) spill at Fire Training Area 5 and contracted the DETOX company to conduct cleanup operations. After...several months of pumping, DETOX estimated that only 300 gallons of the fuel had been recovered. Wright-Patterson Air Force Base, unsatisfied with

Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901.

PubMed

Torti, Vince R; Wojciechowicz, Donald; Hu, Wenyue; John-Baptiste, Annette; Evering, Winston; Troche, Gabriel; Marroquin, Lisa D; Smeal, Tod; Yamazaki, Shinji; Palmer, Cynthia L; Burns-Naas, Leigh Ann; Bagrodia, Shubha

2012-10-01

Clinical trials of selective RAF inhibitors in patients with melanoma tumors harboring activated BRAFV600E have produced very promising results, and a RAF inhibitor has been approved for treatment of advanced melanoma. However, about a third of patients developed resectable skin tumors during the course of trials. This is likely related to observations that RAF inhibitors activate extracellular signal-regulated kinase (ERK) signaling, stimulate proliferation, and induce epithelial hyperplasia in preclinical models. Because these findings raise safety concerns about RAF inhibitor development, we further investigated the underlying mechanisms. We showed that the RAF inhibitor PF-04880594 induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. Hyperplasia and ERK hyperphosphorylation are prevented by treatment with the mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitor PD-0325901 at exposures that extrapolate to clinically well-tolerated doses. To facilitate mechanistic and toxicologic studies, we developed a three-dimensional cell culture model of epithelial layering that recapitulated the RAF inhibitor-induced hyperplasia and reversal by MEK inhibitor in vitro. We also showed that PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells, suggesting a possible mechanism for the skin flushing observed in dogs. The complete inhibition of hyperplasia by MEK inhibitor in epithelial tissues does not seem to reduce RAF inhibitor efficacy and, in fact, allows doubling of the PF-04880594 dose without toxicity usually associated with such doses. These findings indicated that combination treatment with MEK inhibitors might greatly increase the safety and therapeutic index of RAF inhibitors for the treatment of melanoma and other cancers. ©2012 AACR.

Investigation of Ground Water Pollution at Air Force Plant Number 4, Fort Worth Texas

DTIC Science & Technology

1986-10-01

Dbtibz~o Ud~mxtm!UCTtq! - INVESTIGATION OF GROUND WATER POLLUTION AT - AIR FORCE PLANT NO. 4 FORT WORTH, TEXAS REPORT TO - UNITED STATES AIR FORCE...performed at the plant : Three pairs of Paluxy monitoring wells weze drilled along the south boundary of the plant to determine if pollutants discovered in...a nonhazardous dye tracer in selected wells. v U, INVESTIGATION OF POLLUTION OF GROUND WATER IN THE PALUXY AQUIFER AT AIR FORCE PLANT NO. 4, FORT

Air Force Journal of Logistics. Volume XXIII, Number 4, Winter 1999

DTIC Science & Technology

1999-01-01

needs of the Air Force. 2. Uses existing software developed by base-level Air Force Reserve Command units as a benchmark. MSgt Maura A. Barton, DSN... Maura A. Barton, DSN 596-4581 Follow-on Technical Support for the Weapons Load Crew Management Program LM199812000—Consulting Study 1. Ensures the... Kelly AFB, an aging munitions infrastructure, and current runway restrictions for airlift aircraft make the future of that STAMP location uncertain

Forced-Air Warmers and Surgical Site Infections in Patients Undergoing Knee or Hip Arthroplasty.

PubMed

Austin, Paul N

2017-01-01

The majority of the evidence indicates preventing inadvertent perioperative hypothermia reduces the incidence of many perioperative complications. Among the results of inadvertent perioperative hypothermia are increased bleeding, myocardial events, impaired wound healing, and diminished renal function. Most researchers agree there is an increased incidence of surgical site infections in patients who experience inadvertent perioperative hypothermia. Forced-air warming is effective in preventing inadvertent perioperative hypothermia. Paradoxically, forced-air warmers have been implicated in causing surgical site infections in patients undergoing total knee or hip arthroplasty. The results of investigations suggest these devices harbor pathogens and cause unwanted airflow disturbances. However, no significant increases in bacterial counts were found when forced-air warmers were used according to the manufacturer's directions. The results of one study suggested the incidence of surgical site infections in patients undergoing total joint arthroplasty was increased when using a forced-air warmer. However these researchers did not control for other factors affecting the incidence of surgical site infections in these patients. Current evidence does not support forced-air warmers causing surgical site infections in patients undergoing total knee or hip arthroplasty. Clinicians must use and maintain these devices as per the manufacturer's directions. They may consider using alternative warming methods. Well-conducted studies are needed to help determine the role of forced-air warmers in causing infections in these patients.

76 FR 75453 - Restricted Areas and Danger Zones at Eglin Air Force Base, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-02

... and Danger Zones at Eglin Air Force Base, FL AGENCY: U.S. Army Corps of Engineers, Department of... within the Eglin Air Force Base (AFB) facilities and along the Eglin AFB facility shoreline in Florida... have the permission of the Commander, 96 Air Base Wing, Eglin AFB or his/her authorized representative...

Installation Restoration Program. Phase II. Confirmation/Quantification. Stage I. Tyndall Air Force Base, Florida.

DTIC Science & Technology

1984-08-01

10 31984 . PREPARED FOR UNITED STATES AIR FORCE OCCUPATIONAL AND ENVIRONMENTAL HEALTH LABORATORY BROOKS AIR FORCE BASE, TEXAS 78235 ,,c.’p! ed di...Force August 1984 Occupational and Environmental Health Laboratory I3 NUMBER OF PAGES Aerospace Medical Division (AFSC) 249 total pages• ~~Brooks Air...PROGRAM BACKGROUND i-I 1.2 FACILITY HISTORY 1-3 1.3 DISPOSAL SITE DESCRIPTIONS 1-b 1.4 PROJECT STAFF 1-20 2.0 ENVIRONMENTAL SETTING 2-1 2.1 METEOROLOGY 2-1

Resilient Airmen: Pacific Air Forces’ Critical Enabler

DTIC Science & Technology

2015-02-01

VIEWS T he sun never sets on Pacific Air Forces (PACAF). From Alaska to Antarctica and from California to India, PACAF’s area of re- sponsibility...and defend US interests. This article not only addresses the meaning of resiliency but also-and more importantly-examines why it is critical to...it demonstrates how the RA LOO is part of larger, strategic game plan to inject resiliency into our entire force structure as a means of fulfilling

International Cooperation with Partner Air Forces

DTIC Science & Technology

2009-01-01

AND HEALTH CARE INTERNATIONAL AFFAIRS NATIONAL SECURITY POPULATION AND AGING PUBLIC SAFETY SCIENCE AND TECHNOLOGY SUBSTANCE ABUSE TERRORISM AND...bibliographical references. “MG-203.” ISBN 978-0-8330-4571-3 (pbk. : alk. paper) 1. Combined operations (Military science ) 2. United States. Air Force. 3...Military relations—Foreign countries. 7. Military art and science —International cooperation. I. Moroney, Jennifer D. P., 1973– U260.I53 2009

Project Air Force Annual Report 2007

DTIC Science & Technology

2007-01-01

China has developed options that would make it a formidable adversary, particularly in a conflict over Taiwan , which the United States remains...he focused on China’s relationship with Taiwan . Since then, he has worked with other RAND analysts, such as David Orletsky, Evan Medeiros, Keith Crane...Hamilton, engineers Jeff Hagen and David Vaughan, Air Force Fellow Michelle Grace, behavioral scientist Larry Hanser, and information scientist Herb Shukiar

Project Air Force, Annual Report 2003

DTIC Science & Technology

2003-01-01

to Simulate Personnel Retention The CAPM system is based on a simple assumption about employee retention: A rational individual faced with the...analysis to certain parts of the force. CAPM keeps a complete record of the assumptions , policies, and data used for each scenario. Thus decisionmakers...premises and assumptions . Instead, the Commission concluded that space is a separate oper- ating arena equivalent to the air, land, and maritime

The Air Force Aviation Investment Challenge

DTIC Science & Technology

2015-12-17

7 Procurement percentage excludes modification funding. 8 IOC from Department of Defense, Annual Aviation Inventory and Funding Plan, Fiscal Years...its engineering and manufacturing development phase, is projected to triple over the course of the FYDP. 9 The newer programs begin with relatively...Through a Non-Air Force Budget As part of its markup of the Navy’s proposed FY2015 budget, Congress created the National Sea- Based Deterrence Fund

78 FR 63459 - Names of Members of the Performance Review Board for the Department of the Air Force

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-24

.... Air Force are: 1. Board President--Gen Shelton, Commander, Air Force Space Command 2. Lt Gen... DEPARTMENT OF DEFENSE Department of the Air Force Names of Members of the Performance Review Board for the Department of the Air Force ACTION: Notice. SUMMARY: Notice is given of the names of members...

NORAD, USNORTHCOM and the Mexican Air Force to participate in AMALGAM EAGLE

Science.gov Websites

. Northern Command (USNORTHCOM), will participate, with the Mexican Air Force, in AMALGAM EAGLE 15, a the Mexican Air Force to participate in AMALGAM EAGLE 15 N-NC Public Affairs PRINT | E-MAIL PETERSON tactical exercise, to be conducted Jun.30 - Jul.2, 2015, in which Mexico and the United States will respond

Michigan/Air Force Research Laboratory (AFRL) Collaborative Center in Control Science (MACCCS)

DTIC Science & Technology

2016-09-01

AFRL-RQ-WP-TR-2016-0139 MICHIGAN/AIR FORCE RESEARCH LABORATORY (AFRL) COLLABORATIVE CENTER IN CONTROL SCIENCE (MACCCS) Anouck Girard...Final 18 April 2007 – 30 September 2016 4. TITLE AND SUBTITLE MICHIGAN/AIR FORCE RESEARCH LABORATORY (AFRL) COLLABORATIVE CENTER IN CONTROL SCIENCE...and amplify an internationally recognized center of excellence in control science research and education, through interaction between the faculty and

VIEW, FRONT ELEVATION, LOOKING SOUTHSOUTHEAST Mountain Home Air Force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW, FRONT ELEVATION, LOOKING SOUTH-SOUTHEAST - Mountain Home Air Force Base 1958 Senior Officers' Housing, Colonel's Residence, Tuck Street (originally Locust Street), Mountain Home, Elmore County, ID

A Retrospective Analysis of Initial Posterior Root Canal Therapy on United States Air Force Personnel

DTIC Science & Technology

2016-06-01

and John Yaccino, DDS Abstract Introduction: The Air Force Dental Service (AFDS) has established evidence-based treatment standards for endodontics...and cuspal coverage restorations (4-6). With this research, the Air Force Dental Service (AFDS) established evidence-based treatment standards for...endodontics to ensure Airmen receive high-quality, safe dental care (7). These standards are taught at the two Air Force (AF) Postgraduate Endodontic

Final Environmental Assessment for Low-Level Flight Testing, Evaluation, and Training, Edwards Air Force Base

DTIC Science & Technology

2005-05-01

4. TITLE AND SUBTITLE Final Environmental Assessment for Low-Level Flight Testing, Evaluation, and Training, Edwards Air Force Base 5a. CONTRACT...NAME(S) AND ADDRESS(ES) Air Force Flight Test Center,Environmental Management Directorate,Edwards AFB,CA,93524 8. PERFORMING ORGANIZATION REPORT...DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The U.S. Air Force Flight Test

Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.

PubMed

Shemon, Anne N; Heil, Gary L; Granovsky, Alexey E; Clark, Mathew M; McElheny, Dan; Chimon, Alexander; Rosner, Marsha R; Koide, Shohei

2010-05-05

Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway. RKIP has also been shown to suppress metastasis. We have previously demonstrated that RKIP/Raf interaction is regulated by two mechanisms: phosphorylation of RKIP at Ser-153, and occupation of RKIP's conserved ligand binding domain with a phospholipid (2-dihexanoyl-sn-glycero-3-phosphoethanolamine; DHPE). In addition to phospholipids, other ligands have been reported to bind this domain; however their binding properties remain uncharacterized. In this study, we used high-resolution heteronuclear NMR spectroscopy to screen a chemical library and assay a number of potential RKIP ligands for binding to the protein. Surprisingly, many compounds previously postulated as RKIP ligands showed no detectable binding in near-physiological solution conditions even at millimolar concentrations. In contrast, we found three novel ligands for RKIP that specifically bind to the RKIP pocket. Interestingly, unlike the phospholipid, DHPE, these newly identified ligands did not affect RKIP binding to Raf-1 or RKIP phosphorylation. One out of the three ligands displayed off target biological effects, impairing EGF-induced MAPK and metabolic activity. This work defines the binding properties of RKIP ligands under near physiological conditions, establishing RKIP's affinity for hydrophobic ligands and the importance of bulky aliphatic chains for inhibiting its function. The common structural elements of these compounds defines a minimal requirement for RKIP binding and thus they can be used as lead compounds for future design of RKIP ligands with therapeutic potential.

Installation Restoration Program Records Search for Langley Air Force Base, Virginia

DTIC Science & Technology

1982-06-01

Septic Tanks at Langley Air Force Base 12 Location of Oil /Water Separators at Langley Air Force Base 13 Location Map of Possible Contaminated Area at...No. J.) and old vehicle dumping area (Site No. 15). A-17 Location of old underground fuel lines--possible oil -saturated area. vi FIGURES--Continued A...18 Location of old wastewater treatment plant at the Main Base Area (Site No. 2). A-19 Location of old underground oil storage tanks-possible oil

STS-92 - Landing at Edwards Air Force Base

NASA Image and Video Library

2000-10-24

With its drag parachute deployed to help slow it down, the Space Shuttle Discovery rolls down the runway after landing at Edwards Air Force Base in Southern California at the conclusion of mission STS-92 on October 24, 2000.

33 CFR 334.710 - The Narrows and Gulf of Mexico adjacent to Santa Rosa Island, Air Force Proving Ground Command...

Code of Federal Regulations, 2011 CFR

2011-07-01

... adjacent to Santa Rosa Island, Air Force Proving Ground Command, Eglin Air Force Base, Fla. 334.710 Section... Santa Rosa Island, Air Force Proving Ground Command, Eglin Air Force Base, Fla. (a) The restricted area... regulations in this section shall be enforced by the Commander, Air Force Proving Ground Command, Eglin Air...

78 FR 26758 - U.S. Air Force Scientific Advisory Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... Board (SAB) meeting will take place 25 June 2013 at the Secretary of the Air Force Technical and... States Air Force Scientific Advisory Board should submit a written statement in accordance with 41 CFR... in this paragraph. Written statements can be submitted to the Designated Federal Officer at the...

An Analysis of the Populations of the Air Force's Medical and Professional Officer Corps.

PubMed

Keating, Edward G; Massey, Hugh G; Mele, Judith D; Mundell, Benjamin F

2012-01-01

Since the advent of the all-volunteer force, one of the foremost personnel challenges of the U.S. Air Force has been recruiting and retaining an adequate number of medical and professional officers in the Air Force's seven medical and professional officer corps: the Biomedical Sciences Corps (BSC), the Chaplain Corps, the Dental Corps, the Judge Advocate General (JAG) Corps (attorneys), the Medical Corps (physicians), the Medical Service Corps (MSC), and the Nurse Corps. For each of these corps, there are highly similar jobs in the private sector, so attracting and retaining these corps' officers is a constant challenge. This article analyzes all seven Air Force medical and professional officer corps and their relative statuses with regard to end strengths, accession levels, promotion flow, and attrition since the late 1970s. The authors find that recent accession and retention trends have been most adverse in the Air Force's Nurse Corps, while the MSC and the JAG Corps appear to have the most stable populations.

Fairchild takes in evacuated McConnell KC-135s > U.S. Air Force > Article

Science.gov Websites

The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games 2017 Events 2018 Air Force Strategic Documents Desert Storm 25th Anniversary Observances DoD Warrior Games

U.S. Air Force > About Us > Observances

Science.gov Websites

Media Sites Site Registration Contact Us Search AF.mil: Highlights APIM-Rotator Womens History Month African American History Month posters African American History Month Asian American Pacific Islander . (U.S. Air Force photo by Staff Sgt. Will McCrary/Released). USAFE band member discovers family history

Air Force and the Cyberspace Mission: Defending the Air Force’s Computer Network in the Future

DTIC Science & Technology

2007-12-01

computers, their operating systems and software purchased by the Air Force are commercial off-the-shelf (COTS) components, often manufactured abroad due...crystal clear 2003 information security report: “The U.S. Department of Defense (DOD) relies too much on commercial software , doesn’t know who is...creating the software , and faces other significant cybersecurity problems.”11 This paper explores the topic of defense of the cyberspace domain by

Anthropometry of Brazilian Air Force pilots.

PubMed

da Silva, Gilvan V; Halpern, Manny; Gordon, Claire C

2017-10-01

Anthropometric data are essential for the design of military equipment including sizing of aircraft cockpits and personal gear. Currently, there are no anthropometric databases specific to Brazilian military personnel. The aim of this study was to create a Brazilian anthropometric database of Air Force pilots. The methods, protocols, descriptions, definitions, landmarks, tools and measurements procedures followed the instructions outlined in Measurer's Handbook: US Army and Marine Corps Anthropometric Surveys, 2010-2011 - NATICK/TR-11/017. The participants were measured countrywide, in all five Brazilian Geographical Regions. Thirty-nine anthropometric measurements related to cockpit design were selected. The results of 2133 males and 206 females aged 16-52 years constitute a set of basic data for cockpit design, space arrangement issues and adjustments, protective gear and equipment design, as well as for digital human modelling. Another important implication is that this study can be considered a starting point for reducing gender bias in women's career as pilots. Practitioner Summary: This paper describes the first large-scale anthropometric survey of the Brazilian Air Force pilots and the development of the related database. This study provides critical data for improving aircraft cockpit design for ergonomics and comprehensive pilot accommodation, protective gear and uniform design, as well as digital human modelling.

32 CFR 644.392 - Air Force-preliminary report of excess.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 4 2014-07-01 2013-07-01 true Air Force-preliminary report of excess. 644.392... PROPERTY REAL ESTATE HANDBOOK Disposal Predisposal Action § 644.392 Air Force—preliminary report of excess... Armed Services Committees of the Congress.) When the preliminary real estate disposal directive is...

F-22 Operational Squadron and T-38 Detachment Beddown at Tyndall Air Force Base, Florida