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Sample records for airport philadelphia philadelphia

  1. 76 FR 19518 - Notice of Intent to Rule on Request To Release Airport Property at the Northeast Philadelphia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... Federal Aviation Administration Notice of Intent to Rule on Request To Release Airport Property at the Northeast Philadelphia Airport (PNE), Philadelphia, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA proposes to rule and...

  2. Synthetic aperture radar imagery of airports and surrounding areas: Philadelphia Airport

    NASA Technical Reports Server (NTRS)

    Onstott, Robert G.; Gineris, Denise J.

    1990-01-01

    The statistical description of ground clutter at an airport and in the surrounding area is addressed. These data are being utilized in a program to detect microbursts. Synthetic Aperture Radar (SAR) data were collected at the Philadelphia Airport. These data and the results of the clutter study are described. This 13 km x 10 km scene was imaged at 9.38 GHz and HH-polarization and contained airport grounds and facilities (6 percent), industrial (14 percent), residential (14 percent), fields (10 percent), forest (8 percent), and water (33 percent). Incidence angles ranged from 40 to 84 deg. Even at the smallest incidence angles, the distributed targets such as forest, fields, water, and residential rarely had mean scattering coefficients greater than -10 dB. Eighty-seven percent of the image had scattering coefficients less than -17.5 dB. About 1 percent of the scattering coefficients exceeded 0 dB, with about 0.1 percent above 10 dB. Sources which produced the largest cross sections were largely confined to the airport grounds and areas highly industrialized. The largest cross sections were produced by observing broadside large buildings surrounded by smooth surfaces.

  3. 77 FR 43136 - Approval of Noise Compatibility Program for Philadelphia International Airport, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... and management of the navigable airspace and air traffic control systems, or adversely affecting other... decision on a request to implement the action, an ] environmental review of the proposed action may be... comprised of actions designed for phased implementation by airport management and adjacent...

  4. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  5. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  6. 20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.25. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  7. Philadelphia and the Tomato.

    ERIC Educational Resources Information Center

    Smith, Andrew F.; Kling, Tatiana

    This booklet describes for elementary students the many contributions of people, traveling many places, over many years to bring the tomato to Philadelphia. The booklet includes the following: (1) "Introduction to the Tomato"; (2) "Where Does the Tomato Come From?"; (3) "The Spanish Tomato"; (4) "The Philadelphia Tomato"; (5) "Growing Tomato…

  8. 76 FR 409 - Philadelphia International Airport, Capacity Enhancement Program, Environmental Impact Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ..., 2010 (75 FR 52736). The Final EIS was prepared in compliance with the National Environmental Policy Act... Metropolitan Area during all weather conditions. This ROD sets forth FAA's final determination and... demand in the Philadelphia Metropolitan Area during all weather conditions. The Environmental...

  9. Undergraduate Program: Philadelphia

    NASA Astrophysics Data System (ADS)

    Betsock, Lori

    2008-08-01

    Undergraduate chemical science students—join us in Philadelphia on August 17 and 18, 2008, for an educational and career-oriented program designed specifically for you. Attend symposia about global climate change and clean energy; hear Nobel Laureate F. Sherwood Rowland speak about his fascinating career, "A Life in Tracer Chemistry". Weigh options for your future by attending the Graduate School Reality Check and graduate school recruiting events. All events will take place in the Sheraton Philadelphia City Center at 17th and Race Streets, except the Undergraduate Poster Sessions and Sci-Mix, which will be held in the Pennsylvania Convention Center.

  10. The Philadelphia Story

    ERIC Educational Resources Information Center

    Finkelstein, Leonard B.

    1973-01-01

    Describes Philadelphia's massive program of alternatives at the secondary school level. According to the author, more than fifty alternative programs are now in existence -- some within a school, some functioning as annexes in off-site locations, and others operating as semiautonomous organizations. (Author/JF)

  11. School Closings in Philadelphia

    ERIC Educational Resources Information Center

    Jack, James; Sludden, John

    2013-01-01

    In 2012, the School District of Philadelphia closed six schools. In 2013, it closed 24. The closure of 30 schools has occurred amid a financial crisis, headlined by the district's $1.35 billion deficit. School closures are one piece of the district's plan to cut expenditures and close its budget gap. The closures are also intended to…

  12. SOUTHEAST FRONT ELEVATION, LOOKING NORTHWEST, SHOWING PHILADELPHIA THANKSGIVING PARADE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTHEAST FRONT ELEVATION, LOOKING NORTHWEST, SHOWING PHILADELPHIA THANKSGIVING PARADE - Free Library of Philadelphia, Thomas Holme Branch, 7810 Frankford Avenue, Philadelphia, Philadelphia County, PA

  13. 10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  14. 8. Pennsylvania Railroad: 30th Street Station Powerhouse. Philadelphia, Philadelphia Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Pennsylvania Railroad: 30th Street Station Powerhouse. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  15. 11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  16. 9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  17. View southeast; lower bracing connection Naval Base PhiladelphiaPhiladelphia Naval ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View southeast; lower bracing connection - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure No. 841, Delaware Avenue between East Fourth Street & Webster Avenue, League Island, Philadelphia, Philadelphia County, PA

  18. View southwest; north and east facades Naval Base PhiladelphiaPhiladelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View southwest; north and east facades - Naval Base Philadelphia-Philadelphia Naval Shipyard, Foundry-Propeller Shop, North of Porter Avenue, west of Third Street West, Philadelphia, Philadelphia County, PA

  19. View northwest; south and east facades Naval Base PhiladelphiaPhiladelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View northwest; south and east facades - Naval Base Philadelphia-Philadelphia Naval Shipyard, Foundry-Propeller Shop, North of Porter Avenue, west of Third Street West, Philadelphia, Philadelphia County, PA

  20. View northeast; interior structural detail Naval Base PhiladelphiaPhiladelphia Naval ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View northeast; interior structural detail - Naval Base Philadelphia-Philadelphia Naval Shipyard, Foundry-Propeller Shop, North of Porter Avenue, west of Third Street West, Philadelphia, Philadelphia County, PA

  1. 6. ANOTHER GRANDSTAND ENTRANCE, EAST WING OF GRANDSTAND. NOTE PHILADELPHIA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. ANOTHER GRANDSTAND ENTRANCE, EAST WING OF GRANDSTAND. NOTE PHILADELPHIA ATHLETICS'S LETTER 'A' ON CARTOUCHE. - Shibe Park (Stadium), 2701 North Twenty-first Street, Philadelphia, Philadelphia County, PA

  2. 13. WEST END, LOOKING NE, PHILADELPHIA ZOO LION SCULPTURE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. WEST END, LOOKING NE, PHILADELPHIA ZOO LION SCULPTURE IN FOREGROUND. - Connecting Railway, Schuylkill River Bridge, Spanning Schuylkill River, north of Girard Avenue Bridge, Philadelphia, Philadelphia County, PA

  3. Overview from west bank of Schuykill River. Philadelphia & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Overview from west bank of Schuykill River. - Philadelphia & Reading Railroad, Bridge at West Falls, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  4. 7. PHOTOCOPY OF PHOTO OF OLD DRAWING OF PHILADELPHIA CONTRIBUTIONSHIP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. PHOTOCOPY OF PHOTO OF OLD DRAWING OF PHILADELPHIA CONTRIBUTIONSHIP BY THOMAS U. WALTER, JULY 24, 1835 - Philadelphia Contributionship, House Fire Insurance, 212 South Fourth Street, Philadelphia, Philadelphia County, PA

  5. 2. Photocopy of the fountain in front of Philadelphia Museum ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of the fountain in front of Philadelphia Museum of Art, ca. 1928, courtesy of Philadelphia Museum of Art - Fountain of the Sea Horses, Aquarium Lane, Philadelphia, Philadelphia County, PA

  6. Philadelphia's "Servant-Leader" Superintendent

    ERIC Educational Resources Information Center

    Puente, Kelly

    2012-01-01

    This article profiles William Hite, Jr., a longtime educator and administrator, who began his career more than two decades ago as a high school athletic coach. Hite says his biggest passion is educating young people. And one of the best ways to serve students, he says, is by listening. Hite, 51, assumed his duties as Philadelphia's new…

  7. Building 21: B21 Philadelphia

    ERIC Educational Resources Information Center

    EDUCAUSE, 2015

    2015-01-01

    As a non-selective neighborhood high school in the School District of Philadelphia, B21's mission is to empower networks of learners to connect with their passions and build agency to impact their world. Building 21 is organized into studios, workshops, and advisories. Core studios engage students in project-based learning. Blended learning…

  8. Philadelphia

    Atmospheric Science Data Center

    2014-05-15

    ... and bridges extends northward along the coast from Delaware Bay. A popular tourist destination for those wanting to avoid the crowds and ... cuts transversely across these folded formations toward the Chesapeake Bay in Havre de Grace, Maryland, where it provides 50 percent of all ...

  9. 2. Photocopy of photograph (from Moses King, Philadelphia and Notable ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of photograph (from Moses King, Philadelphia and Notable Philadelphians , 1902, p. 260) OBLIQUE VIEW, SHOWING SOUTH (FRONT) AND EAST(SIDE) ELEVATIONS - Old U.S. Mint, Chestnut & Juniper Streets, Philadelphia, Philadelphia County, PA

  10. Interior view; Street Car Waiting House North Philadelphia Station, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view; Street Car Waiting House - North Philadelphia Station, Street Car Waiting House, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  11. 11. SOUTH (REAR) ELEVATION OF THE PHILADELPHIA SAVING FUND SOCIETY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. SOUTH (REAR) ELEVATION OF THE PHILADELPHIA SAVING FUND SOCIETY (PSFS) BUILDING WITH MEETING HOUSE CORNICE IN FOREGROUND. - Twelfth Street Meeting House, 20 South Twelfth Street, Philadelphia, Philadelphia County, PA

  12. 5. AERIAL VIEW LOOKING NORTH SHOWING PHILADELPHIA MUSEUM OF ART, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. AERIAL VIEW LOOKING NORTH SHOWING PHILADELPHIA MUSEUM OF ART, SITE OF FORMER MAIN STORAGE RESERVOIR - Fairmount Waterworks, East bank of Schuylkill River, Aquarium Drive, Philadelphia, Philadelphia County, PA

  13. Philadelphia Alternative Diploma Project. 1996-1997.

    ERIC Educational Resources Information Center

    Philadelphia School District, PA.

    A project was conducted in Philadelphia to help adult students obtain a high school diploma as an alternative to or enhancement of a General Educational Development (GED) certificate. During fiscal year 1996-97 the Metropolitan Career Center (MCC), in collaboration with the School District of Philadelphia, designed an Alternative Diploma Program…

  14. Comprehensive District Reform: Philadelphia's Grand Experiment.

    ERIC Educational Resources Information Center

    Useem, Elizabeth; Balfanz, Robert

    2002-01-01

    This report describes "Philadelphia's Grand Experiment" in comprehensive school district reform, from its conception through its initial months of implementation. In 2001, as part of the remedy for low student performance, the governor ordered the state to take over governance of the Philadelphia School District, with a substantial number of…

  15. Presidential Events and Symposia: Philadelphia

    NASA Astrophysics Data System (ADS)

    2008-08-01

    During 2008, ACS President Bruce E. Bursten is highlighting energy development, education initiatives, enhanced communication of the centrality of chemistry, and international cooperation between chemists and chemical engineers. At the Philadelphia meeting there is a symposium on global energy challenges and opportunities on Monday afternoon. Beginning Sunday afternoon with a special symposium, and continuing throughout the week, we will celebrate the centrality of chemistry through the disciplines of agriculture and food chemistry, industrial and engineering chemistry, organic chemistry, and physical chemistry, as we observe the centennial of the divisions representing those disciplines. Other symposia sponsored by the president include the 40th Anniversary of Project SEED and the Astellas Foundation Award Lectures in Transitional Chemistry, a new national award. It promises to be an exciting time. These and other events that are cosponsored by the ACS President are listed.

  16. Philadelphia Printing and Publishing, 1876-1976

    ERIC Educational Resources Information Center

    Whitehead, Thomas M.

    1976-01-01

    Two Philadelphia printing histories, both reflecting the relationship of printing to publishing, are examined in this article: the manufacture by the publisher of his own product and the development and commercialization of the photomechanical halftone process. (Author)

  17. Philadelphia Eagles Honor NASA Astronaut Chris Ferguson

    NASA Video Gallery

    NASA astronaut Chris Ferguson returned to his hometown on Nov. 7 to serve as the Philadelphia Eagles' Honorary Captain during the NFL's "Monday Night Football" game. The Eagles hosted the Chicago B...

  18. The Philadelphia Face Perception Battery

    PubMed Central

    Thomas, Amy; Lawler, Kathy; Olson, Ingrid R; Aguirre, Geoffrey K

    2008-01-01

    The Philadelphia Face Perception Battery (PFPB) tests four aspects of face perception: discrimination of facial similarity, attractiveness, gender, and age. Calibration with 116 neurologically intact subjects yielded average performance of ~90%. Across subjects, there was a low correlation (<0.22) in performance between the tests (with the exception of the attractiveness and age discrimination tests) suggesting that the tests measure independent aspects of face perception. There were modest effects of subject demographic factors upon performance, and test-retest reliability scores (between 0.37 and 0.75) were comparable to other neuropsychological batteries. Modification of the stimuli to obscure internal facial features lowered performance on the age, gender, and attractiveness discrimination tests between 2 and 4 standard deviations. The clinical sensitivity of the battery was demonstrated by testing a patient with acquired prosopagnosia. She showed performance impairments of between 2 and 4 standard deviations on all sub-tests. The PFPB is freely available for non-commercial use. PMID:18082362

  19. NorthEast view; Platform, canopy, and freight elevator North Philadelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    North-East view; Platform, canopy, and freight elevator - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  20. Ground clutter measurements using the NASA airborne doppler radar: Description of clutter at the Denver and Philadelphia airports

    NASA Technical Reports Server (NTRS)

    Harrah, Steven D.; Delnore, Victor E.; Goodrich, Michael S.; Vonhagel, Chris

    1992-01-01

    Detection of hazardous wind shears from an airborne platform, using commercial sized radar hardware, has been debated and researched for several years. The primary concern has been the requirement for 'look-down' capability in a Doppler radar during the approach and landing phases of flight. During 'look-down' operation, the received signal (weather signature) will be corrupted by ground clutter returns. Ground clutter at and around urban airports can have large values of Normalized Radar Cross Section (NRCS) producing clutter returns which could saturate the radar's receiver, thus disabling the radar entirely, or at least from its intended function. The purpose of this research was to investigate the NRCS levels in an airport environment (scene), and to characterize the NRCS distribution across a variety of radar parameters. These results are also compared to results of a similar study using Synthetic Aperture Radar (SAR) images of the same scenes. This was necessary in order to quantify and characterize the differences and similarities between results derived from the real-aperature system flown on the NASA 737 aircraft and parametric studies which have previously been performed using the NASA airborne radar simulation program.

  1. Philadelphia-Atlantic City: highballing the highrollers

    SciTech Connect

    Kizzia, T.

    1980-12-08

    An existing 65 mi rail corridor from Philadelphia, Pa., to Atlantic City, N.J., is being studied for redevelopment. The French Compagnie General d'Electricite wants to develop this route for a high speed electric system. Trains would cover the distance in 40 minutes, with top speeds hitting 125 mph. Potential ridership includes casino visitors to Atlantic City and commuters into Philadelphia. The status of the project and its future are outlined. Several other foreign companies are interested in developing some rail lines in the U.S. Congress is taking steps to encourage these private investments in the U.S. rail system. (1 photo)

  2. 1. 3/4 VIEW, LOOKING NE. Philadelphia & Reading Railroad, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 3/4 VIEW, LOOKING NE. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  3. 4. VIEW RECONSTRUCTED TOWER, LOOKING NNE. Philadelphia & Reading ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW RECONSTRUCTED TOWER, LOOKING NNE. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  4. 3. DETAIL OF WEST TOWER, LOOKING NE. Philadelphia & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. DETAIL OF WEST TOWER, LOOKING NE. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  5. 2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. Philadelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  6. 14. LION SCULPTURE, AT THE PHILADELPHIA MUSEUM OF ART, MOVED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. LION SCULPTURE, AT THE PHILADELPHIA MUSEUM OF ART, MOVED FROM MERCHANTS' EXCHANGE, WHERE IT RESTED ON THE STAIR WALL OF SIDE ENTRANCE STAIRS. (A REPLACEMENT LION HAS BEEN PLACED IN THE ORIGINAL SITE, AS DID ANOTHER REPLACEMENT IN THE OTHER SIDE OF THE BUILDING. FOR THIS LATTER REPLACEMENT SEE PA-1028-15). A VIEW OF THE MUSEUM IS IN THE BACKGROUND - Philadelphia Exchange Company, 143 South Third Street, Philadelphia, Philadelphia County, PA

  7. Amachi: Mentoring Children of Prisoners in Philadelphia.

    ERIC Educational Resources Information Center

    Jucovy, Linda

    This report documents the work of Amachi, a mentoring program for children of incarcerated and formerly incarcerated parents in Philadelphia, Pennsylvania. Volunteers are recruited from inner-city congregations to provide one-to-one mentoring to the children. Beyond being the source of mentors, the congregations are a key part of the initiative.…

  8. The State of Black Philadelphia 1982.

    ERIC Educational Resources Information Center

    Lewis, Claude, Ed.; Perry, Carrolle, Ed.

    The articles in this report describe current social conditions of blacks in Philadelphia, Pennsylvania, and examine how government policies can affect such conditions. Brenda Maisha Jefferson Jackson discusses black housing opportunities and the negative impact of racial discrimination, political powerlessness, and economics on these…

  9. Philadelphia's Renaissance Schools Initiative after Four Years

    ERIC Educational Resources Information Center

    Stratos, Kati; Wolford, Tonya; Reitano, Adrienne

    2015-01-01

    In 2010-2011, the School District of Philadelphia (the District) launched its Renaissance Schools Initiative, a program designed to dramatically improve student achievement in the District's lowest performing schools. Some schools became Promise Academies, based on the federal turnaround model, and remained District-operated neighborhood schools.…

  10. Philadelphia's Teacher Appraisal System Needs Improvement

    ERIC Educational Resources Information Center

    Royal, Camika; Tossman, Matthew

    2009-01-01

    The purpose of this paper is to inform the community about teacher appraisal methods in the School District of Philadelphia, outline the difficulties of the current system, and suggest approaches that would strengthen the teacher appraisal process. The authors gathered their information over three months in mid-2009 from multiple sources:…

  11. South Philadelphia Passive Sampler and Sensor Study

    EPA Science Inventory

    Starting in June 2013, the United States Environmental Protection Agency (U.S. EPA) and the City of Philadelphia Air Measurements Services began collaborative research on the use of passive samplers (PSs) and stand-alone air measurement (SAM) systems to improve information on the...

  12. A Snapshot of Philadelphia's Accelerated Schools

    ERIC Educational Resources Information Center

    Edmunds, Kimberly; Fonseca, Ean

    2011-01-01

    This snapshot is a guide to the School District of Philadelphia's (the District's) 13 accelerated high schools in the 2010-11 school year. The accelerated high schools were the result of a partnership between the District and Project U-Turn, a city-wide coalition dedicated to reducing student drop-out and increasing graduation rates and readiness…

  13. Philadelphia, Pennsylvania: Solar in Action (Brochure)

    SciTech Connect

    Not Available

    2011-10-01

    This brochure provides an overview of the challenges and successes of Philadelphia, PA, a 2008 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  14. Impact of Community College of Philadelphia Allied Health Programs on the Philadelphia Region. Report #117.

    ERIC Educational Resources Information Center

    Philadelphia Community Coll., PA.

    This report discusses the Allied Health programs at Community College of Philadelphia (CCP): (1) Clinical Laboratory Technician; (2) Dental Assisting Hygiene; (3) Dental Assisting Certificate; (4) Diagnostic Medical Imaging; (5) Dietetic Technician; (6) Health Information Technology; (7) Medical Assisting and Office Management; (8) Nursing; and…

  15. Strategies for Talent Management: Greater Philadelphia Companies in Action

    ERIC Educational Resources Information Center

    Council for Adult and Experiential Learning (NJ1), 2008

    2008-01-01

    Human capital is one of the critical issues that impacts the Greater Philadelphia region's ability to grow and prosper. The CEO Council for Growth (CEO Council) is committed to ensuring a steady and talented supply of quality workers for this region. "Strategies for Talent Management: Greater Philadelphia Companies in Action" provides insights…

  16. Philadelphia's Renaissance Schools: Start up and Early Implementation. Executive Summary

    ERIC Educational Resources Information Center

    Research for Action, 2011

    2011-01-01

    In April 2009, Superintendent Arlene Ackerman announced her reform plan for the School District of Philadelphia (the District)--"Imagine 2014". Among other major initiatives, "Imagine 2014" laid the groundwork for Philadelphia's Renaissance Schools Initiative. The Renaissance Initiative, set to enter its second year in 2011-12, is an effort to…

  17. African-American Artists in Context: The Philadelphia Art Museum.

    ERIC Educational Resources Information Center

    Verdino-Sullivan, Carla Maria

    1992-01-01

    Reviews two exhibits of visual art at the Philadelphia (Pennsylvania) Art Museum, "Works by African-Americans," which showcases the contributions of nineteenth- and twentieth-century African-American artists; and "Pertaining to Philadelphia," acquisitions from the collection of Julius Bloch, an artist and mentor to many African American artists in…

  18. For-Profit Writes Mandatory Courses for Philadelphia High Schools

    ERIC Educational Resources Information Center

    Olson, Lynn

    2005-01-01

    This article reports how Kaplan K12 Learning Services Group, a division of Kaplan Inc., has developed a new, standardized college-preparatory curriculum for the Philadelphia school district. The curriculum, which made its debut in the Philadelphia district in 2005, was a critical element in the district leadership's plan to improve secondary…

  19. Going Small: Progress & Challenges of Philadelphia's Small High Schools

    ERIC Educational Resources Information Center

    Hartmann, Tracey; Reumann-Moore, Rebecca; Evans, Shani Adia; Haxton, Clarisse; Maluk, Holly; Neild, Ruth Curran

    2009-01-01

    Between 2003 and 2007, and without significant outside funding, the School District of Philadelphia created 25 new small high schools. This study, begun by Research for Action in 2006, follows the start-up and early implementation of these small high schools in Philadelphia. The study found that parents and students are interested in small high…

  20. South Philadelphia Passive Sampler Method project communication sheet

    EPA Science Inventory

    The Environmental Protection Agency, Office of Research and Development (EPA ORD), EPA Region 3, and the City of Philadelphia Air Measurements Services (AMS) are collaborating on research project in South Philadelphia starting in the spring of 2013. This project investigates how...

  1. 78 FR 27025 - Modification of Class B Airspace; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... rulemaking (NPRM) to modify the Philadelphia, PA, Class B airspace area (77 FR 45290, July 31, 2012...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389...; Philadelphia, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This...

  2. 77 FR 63727 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... Operation Regulation; Schuylkill River, Philadelphia, PA in the FR (77 FR 47792). We received no comments on... FR Federal Register NPRM Notice of Proposed Rulemaking Sec. Section Symbol U.S.C. United States Code..., Philadelphia, PA AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is changing...

  3. The Classical Greek Program in the School District of Philadelphia.

    ERIC Educational Resources Information Center

    Masciantonio, Rudolph

    Classical Greek is taught as an elective to over 200 students in seven secondary schools of the School District of Philadelphia. In the past decade the restoration of Greek studies to the classical curriculum was called for, and in 1968 a Greek Curriculum Committee was established in Philadelphia to develop a program and instructional materials.…

  4. Neuroimaging of the Philadelphia Neurodevelopmental Cohort

    PubMed Central

    Satterthwaite, Theodore D.; Elliott, Mark A.; Ruparel, Kosha; Loughead, James; Prabhakaran, Karthik; Calkins, Monica E.; Hopson, Ryan; Jackson, Chad; Keefe, Jack; Riley, Marisa; Mensh, Frank D.; Sleiman, Patrick; Verma, Ragini; Davatzikos, Christos; Hakonarson, Hakon; Gur, Ruben C.; Gur, Raquel E.

    2013-01-01

    The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1,445 adolescents ages 8–21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development. PMID:23921101

  5. Low incidence of painless thyroiditis in the Philadelphia area

    SciTech Connect

    Schorr, A.B.; Miller, J.L.; Shtasel, P.; Rose, L.I.

    1986-06-01

    Publications from the midwestern region of the United States have demonstrated an incidence of 14-23% of painless thyroiditis in hyperthyroid individuals. This possibly could represent a local phenomenon, and perhaps is not typical for other areas of the country. The 24 hour radioactive iodine uptakes in 152 consecutive hyperthyroid individuals in the Philadelphia area were evaluated. No patient in the series, with clinical and biochemical evidence of hyperthyroidism, had painless thyroiditis. It is concluded that the incidence of painless thyroiditis is markedly lower in the Philadelphia area than in the Midwest regions of the United States.

  6. 78 FR 14359 - Verizon Business Networks Services, Inc., Specialist-Tech Customer Service, Philadelphia, PA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Employment and Training Administration Verizon Business Networks Services, Inc., Specialist-Tech Customer Service, Philadelphia, PA; Verizon Business Networks Services, Inc., Specialist-Tech Customer Service...-Tech Customer Service, Philadelphia, Pennsylvania and Verizon Business Networks Services,...

  7. Community College of Philadelphia Survey of 1999 Graduates.

    ERIC Educational Resources Information Center

    Philadelphia Community Coll., PA. Office of Institutional Research.

    The document presents findings from the survey of 1999 graduates conducted by the Community College of Philadelphia (CCP) (Pennsylvania). Results are reported concerning previous college experience, data on transfer to four-year institutions, employment status, college environment and student satisfaction with job preparation, course delivery…

  8. Systemwide Implementation of Project-Based Learning: The Philadelphia Approach

    ERIC Educational Resources Information Center

    Schwalm, Jason; Tylek, Karen Smuck

    2012-01-01

    Citywide implementation of project-based learning highlights the benefits--and the challenges--of promoting exemplary practices across an entire out-of-school time (OST) network. In summer 2009, the City of Philadelphia and its intermediary, the Public Health Management Corporation (PHMC), introduced project-based learning to a network of more…

  9. Service-Learning and Reform in the Philadelphia Public Schools.

    ERIC Educational Resources Information Center

    Hornbeck, David

    2000-01-01

    Philadelphia schools were the first to engage all 200,000 K-12 students in meaningful service-learning activities aligned with district academic standards and learning goals. This has meant providing professional development for 6,000 teachers, forging partnerships with 2,500 community experts and agencies, and developing an efficient evaluation…

  10. Transition to High School: School "Choice" & Freshman Year in Philadelphia

    ERIC Educational Resources Information Center

    Gold, Eva; Evans, Shani Adia; Haxton, Clarisse; Maluk, Holly; Mitchell, Cecily; Simon, Elaine; Good, Deborah

    2010-01-01

    The School District of Philadelphia's tiered system of selective, nonselective, and charter high schools, and the process for high school choice, has created real variation in the degree to which high schools can successfully meet the needs of ninth graders. Research has shown that the ninth grade year is critical in determining a student's…

  11. Desegregation of Urban Schools... Is it Possible? The Philadelphia Story.

    ERIC Educational Resources Information Center

    Hanusey, Richard D.

    Philadelphia's voluntary school desegregation plan is designed to offer pupils the opportunity for educational experiences in multicultural, multiracial schools, and to prevent white flight from the public schools. Strategies for achieving desegregation include the creation of magnet schools, voluntary school pairing, the Alternative for Middle…

  12. WorkReady Philadelphia: Preparing Youth for Job Readiness

    ERIC Educational Resources Information Center

    Pawlowski, Brett

    2010-01-01

    One of the great concerns of the business community involves the workforce pipeline: employers want to be sure that new entries into the labor pool, whether from the K-12 or postsecondary systems, are prepared for the jobs that await them. In Philadelphia, business and community leaders have joined forces to give students workplace learning…

  13. Career Opportunities Program in Philadelphia, Pennsylvania. Report Number 7623.

    ERIC Educational Resources Information Center

    Scheiner, Louis; And Others

    The Career Opportunities Program (COP), established under Title V of the Education Professions Development Act of 1967, was implemented in Philadelphia, Pennsylvania from 1970 through 1975. It served low-income persons, primarily blacks, who had no other means to enter the teaching profession. The primary project goals were to attract capable…

  14. Urban School Dropouts: Data Collection and Analysis in Philadelphia.

    ERIC Educational Resources Information Center

    Herron, William P.; Kemp, Edith S.

    In the late 1960's, educators and researchers became concerned with the dropout problem in large urban school districts. In Philadelphia, the Division of Pupil Personnel and Counseling (PPC) is responsible for collection of this data and reports this information to the state. The process has been computerized to cope with the large volume of data.…

  15. Literacy, Place, and Migration in Philadelphia among Ethnic Chinese

    ERIC Educational Resources Information Center

    Rovito, Michael; Masucci, Michele

    2009-01-01

    We introduce the need for scholars interested in literacy, geography, and cultural studies to examine the role of English language literacy in shaping assimilation experiences of recent immigrant groups. We consider a case study of English language self-efficacy among ethnic Chinese immigrants in the Philadelphia metropolitan area to suggest how…

  16. Philadelphia's Renaissance Schools Initiative: 18 Month Interim Report

    ERIC Educational Resources Information Center

    Gold, Eva; Norton, Michael H.; Good, Deborah; Levin, Stephanie

    2012-01-01

    This report presents Year One (2010-11) school level achievement and attendance outcomes and case study findings from fall 2011 that focused on school leadership and instruction. Thirteen schools were included in the first year of Philadelphia's Renaissance Schools Initiative (2010-11). Of these schools: (1) Four K-8 schools were…

  17. Short-Form Philadelphia Naming Test: Rationale and Empirical Evaluation

    ERIC Educational Resources Information Center

    Walker, Grant M.; Schwartz, Myrna F.

    2012-01-01

    Purpose: To create two matched short forms of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996) that yield similar results to the PNT for measuring anomia. Method: In Study 1, archived naming data from 94 individuals with aphasia were used to identify which PNT items should be included in the short forms. The 2…

  18. Time to Engage? Civic Participation in Philadelphia's School Reform

    ERIC Educational Resources Information Center

    Gold, Eva; Cucchiara, Maia; Simon, Elaine; Riffer, Morgan

    2005-01-01

    Since the state takeover, the Philadelphia school district has created a new governance model, in which for-profits, non-profits, and universities receive contracts to manage schools. Further, these and other organizations also receive contracts to provide a range of additional services. The shift to a public/private institutional structure,…

  19. Gratifications Lost: The 1985 Philadelphia Newspaper Strike and Media Use.

    ERIC Educational Resources Information Center

    Elliott, William R.; Rosenberg, William L.

    A study examined the relationship between newspaper gratifications sought and media use during and after a 1985 strike by unions of two Philadelphia newspapers, and the compensatory media behaviors, if any, people adopted to make up for the loss of their daily newspaper(s). It was hypothesized that during the strike, people would read more…

  20. The politics of urban informality in Philadelphia's recovery house movement.

    PubMed

    Fairbanks II, Robert P

    2011-01-01

    There are some 60,000 vacant properties in the city of Philadelphia, 30,000 of which are abandoned row houses. In the neighbourhood of Kensington, street-level entrepreneurs have reconfigured hundreds of former working-class row homes to produce the Philadelphia recovery house movement: an extra-legal poverty survival strategy for addicts and alcoholics located in the city's poorest and most heavily blighted zones. The purpose of this paper is to explore, ethnographically, the ways in which informal poverty survival mechanisms articulate with the restructuring of the contemporary welfare state and the broader political economy of Philadelphia. It is argued that recovery house networks accommodate an interrelated set of political rationalities animated not only by retrenchment and the churning of welfare bodies, but also by the agency of informal operators and the politics of self-help. Working as an alternative and partially vestigial boundary institution or buffer zone to formal regimes of governance, the recovery house movement reflects the ‘other story’ of the new urban politics in Philadelphia.

  1. Actionable Intelligence about Early Childhood Risks in Philadelphia

    ERIC Educational Resources Information Center

    LeBoeuf, Whitney A.; Barghaus, Katherine; Fantuzzo, John; Coe, Kristen; Brumley, Benjamin

    2016-01-01

    "Early childhood risks" are markers of early childhood experiences that extensive research has shown to be detrimental to later academic and behavioral outcomes. In Philadelphia, evidence indicates that seven early childhood risks tracked by public agencies have negative effects on early school outcomes. These risks include low…

  2. South Philadelphia Passive Sampler and Sensor Study - Interim Report

    EPA Science Inventory

    Starting in the June 2013, the U.S. EPA and the City of Philadelphia Air Measurements Services (AMS) began a collaborative research project to investigate how sensor-based, stand-alone air measurements (SAMs) and passive samplers (PSs) can help improve information on air pollutan...

  3. South Philadelphia Passive Sampler and Sensor Study: Interim Report

    EPA Science Inventory

    Starting in June 2013, the United States Environmental Protection Agency (U.S. EPA) and the City of Philadelphia Air Measurements Services began collaborative research on the use of passive samplers (PSs) and stand-alone air measurement (SAM) systems to improve information on the...

  4. The Philadelphia School District's Ongoing Financial Crisis

    ERIC Educational Resources Information Center

    Caskey, John; Kuperberg, Mark

    2014-01-01

    This article describes the budget crisis that the School District of Philadelphia has faced for the past few years. Three specific events triggered the 2012 crisis: an abrupt reduction in federal and state funding, the inability of the district to cut many of its costs, and political pressures on the district to spend available revenues in a given…

  5. The Library Company of Philadelphia: Historical Survey, Bibliography, Chronology.

    ERIC Educational Resources Information Center

    Sable, Martin H.

    1987-01-01

    Traces the history of the Library Company of Philadelphia, which was founded by Benjamin Franklin. Early book selection and scope of the collection, subsequent growth and development, and the various directors of the company are described. The bibliography includes publications of the Library Company and publications about the Library Company.…

  6. A Research Brief: "Principals' Hiring of Teachers in Philadelphia"

    ERIC Educational Resources Information Center

    Ramirez, Heidi A.; Schofield, Lynne Steuerle; Black, Melissa

    2008-01-01

    The School District of Philadelphia (SDP), like many other urban school districts, struggles to increase its hiring and retention of experienced and highly qualified teachers in its low-performing/high-need schools. Excluding its charter schools, SDP serves approximately 165,000 students, largely from high-poverty (76%) and minority (85%)…

  7. Challenges to Freshman Year Interventions in Philadelphia. Policy Brief

    ERIC Educational Resources Information Center

    Research for Action, 2010

    2010-01-01

    Philadelphia made early investments in reforms designed to address the challenges of large neighborhood high schools, including supports for the critical ninth grade transition year. Well over a decade later, our research shows that freshman year interventions are frequently not implemented in ways that maximize their effectiveness. This policy…

  8. Item Response Theory Modeling of the Philadelphia Naming Test

    ERIC Educational Resources Information Center

    Fergadiotis, Gerasimos; Kellough, Stacey; Hula, William D.

    2015-01-01

    Purpose: In this study, we investigated the fit of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996) to an item-response-theory measurement model, estimated the precision of the resulting scores and item parameters, and provided a theoretical rationale for the interpretation of PNT overall scores by relating…

  9. Identity Performance and Collectivist Leadership in the Philadelphia Student Union

    ERIC Educational Resources Information Center

    Rosen, Sonia M.

    2016-01-01

    Youth organizing work benefits young people in myriad ways, equipping them with the skills and dispositions to organize around the systemic inequities and policy decisions that threaten their communities. The findings from this life histories study in the Philadelphia Student Union (PSU) reveal that the organization's collectivist leadership model…

  10. Lodging Management Career Questionnaire of Greater Philadelphia Area.

    ERIC Educational Resources Information Center

    Bennett, Robert C., Jr.; Wetzel, Susan J.

    A survey was undertaken by Delaware County Community College's (Pennsylvania) Hotel/Restaurant Management program: (1) to provide students with local up-to-date information regarding the lodging industry in the Greater Philadelphia area; and (2) to provide information regarding necessary skills as perceived by the managers for the purpose of…

  11. De Renatu Linguarum Antiquarum in Scholis Publicis Philadelphiae (On the Revival of Classical Languages in the Public Schools of Philadelphia)

    ERIC Educational Resources Information Center

    Masciantonio, Rudolph

    1977-01-01

    The enrollment in Latin and Greek classes in the Philadelphia public schools has increased greatly in the last ten years. Courses are offered in elementary as well as secondary schools. An audiolingual approach is used. Available from Universitaet des Saarlandes, Fachbereich 6.2, D-6600 Saarbrueken, West Germany. (Text is in Latin.) (CFM)

  12. Demonstration Assessment of LED Roadway Lighting: Philadelphia, PA

    SciTech Connect

    Royer, Michael P.; Tuenge, Jason R.; Poplawski, Michael E.

    2012-09-01

    For this demonstration assessment, 10 different groups of LED luminaires were installed at three sites in Philadelphia, PA. Each of the three sites represented a different set of conditions, most importantly with regard to the incumbent HPS luminaires, which were nominally 100 W, 150 W, and 250 W. The performance of each product was evaluated based on manufacturer data, illuminance calculations, field measurements of illuminance, and the subjective impressions of both regular and expert observers.

  13. The Recovery Act is "Lighting Up" the streets of Philadelphia

    SciTech Connect

    Nutter, Michael; Gajewski, Katherine; Russell, Toby; Williams, Doug; Best, DeLain

    2010-01-01

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. The project will use approximately $3 million in EECBG funds, matched with $3 million in PECO funding, and will save the city approximately $1 million in electric costs each year. For more information on Recovery Act projects funded by the Department of Energy in Pennsylvania: http://www.energy.gov/recovery/pa.htm

  14. The Recovery Act is "Lighting Up" the streets of Philadelphia

    ScienceCinema

    Nutter, Michael; Gajewski, Katherine; Russell, Toby; Williams, Doug; Best, DeLain

    2016-07-12

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. The project will use approximately $3 million in EECBG funds, matched with $3 million in PECO funding, and will save the city approximately $1 million in electric costs each year. For more information on Recovery Act projects funded by the Department of Energy in Pennsylvania: http://www.energy.gov/recovery/pa.htm

  15. Racial Disparities In Geographic Access To Primary Care In Philadelphia.

    PubMed

    Brown, Elizabeth J; Polsky, Daniel; Barbu, Corentin M; Seymour, Jane W; Grande, David

    2016-08-01

    Primary care is often thought of as the gateway to improved health outcomes and can lead to more efficient use of health care resources. Because of primary care's cardinal importance, adequate access is an important health policy priority. In densely populated urban areas, spatial access to primary care providers across neighborhoods is poorly understood. We examined spatial variation in primary care access in Philadelphia, Pennsylvania. We calculated ratios of adults per primary care provider for each census tract and included buffer zones based on prespecified drive times around each tract. We found that the average ratio was 1,073; the supply of primary care providers varied widely across census tracts, ranging from 105 to 10,321. We identified six areas of Philadelphia that have much lower spatial accessibility to primary care relative to the rest of the city. After adjustment for sociodemographic and insurance characteristics, the odds of being in a low-access area were twenty-eight times greater for census tracts with a high proportion of African Americans than in tracts with a low proportion of African Americans. PMID:27503960

  16. Urban ecosystem services and decision making for a green Philadelphia

    USGS Publications Warehouse

    Hogan, Dianna M.; Shapiro, Carl D.; Karp, David N.; Wachter, Susan M.

    2014-01-01

    Traditional approaches to urban development often do not account for, or recognize, the role of ecosystem services and the benefits these services provide to the health and well-being of city residents. Without such accounting, urban ecosystem services are likely to be degraded over time, with negative consequences for the sustainability of cities and the well-being of their residents (Millennium Ecosystem Assessment, 2005; Hirsch, 2008). On May 23, 2013, the Spatial Integration Laboratory for Urban Systems (SILUS), a collaboration between the U.S. Geological Survey (USGS) Science and Decisions Center and the Wharton GIS Lab, convened a one-day symposium—Urban Ecosystem Services and Decision Making: A Green Philadelphia—at the University of Pennsylvania in Philadelphia, Pennsylvania, to examine the role of green infrastructure in the environmental, economic, and social well-being of cities. Cosponsored by the USGS and the Penn Institute for Urban Research (Penn IUR), the symposium brought together policymakers, practitioners, and researchers from a range of disciplines to advance a research agenda on the use of science in public decision making to inform investment in green infrastructure and ecosystem services in urban areas. The city of Philadelphia has recently implemented a program designed to sustain urban ecosystem services and advance the use of green infrastructure. In 2009, the Philadelphia Mayor’s Office of Sustainability launched its Greenworks plan, establishing a citywide sustainability strategy. Major contributions towards its goals are being implemented in coordination with the Philadelphia Water Department (PWD). The Green City, Clean Waters initiative, the city’s nationally recognized stormwater management plan, was signed into action with the U.S. Environmental Protection Agency (EPA) in April 2012. The plan outlines a 25-year strategy to use green infrastructure to protect and improve the city’s watershed. Widespread support for the

  17. Urban ecosystem services and decision making for a green Philadelphia

    USGS Publications Warehouse

    Hogan, Dianna M.; Shapiro, Carl D.; Karp, David N.; Wachter, Susan M.

    2014-01-01

    Traditional approaches to urban development often do not account for, or recognize, the role of ecosystem services and the benefits these services provide to the health and well-being of city residents. Without such accounting, urban ecosystem services are likely to be degraded over time, with negative consequences for the sustainability of cities and the well-being of their residents (Millennium Ecosystem Assessment, 2005; Hirsch, 2008). On May 23, 2013, the Spatial Integration Laboratory for Urban Systems (SILUS), a collaboration between the U.S. Geological Survey (USGS) Science and Decisions Center and the Wharton GIS Lab, convened a one-day symposium—Urban Ecosystem Services and Decision Making: A Green Philadelphia—at the University of Pennsylvania in Philadelphia, Pennsylvania, to examine the role of green infrastructure in the environmental, economic, and social well-being of cities. Cosponsored by the USGS and the Penn Institute for Urban Research (Penn IUR), the symposium brought together policymakers, practitioners, and researchers from a range of disciplines to advance a research agenda on the use of science in public decision making to inform investment in green infrastructure and ecosystem services in urban areas. The city of Philadelphia has recently implemented a program designed to sustain urban ecosystem services and advance the use of green infrastructure. In 2009, the Philadelphia Mayor’s Office of Sustainability launched its Greenworks plan, establishing a citywide sustainability strategy. Major contributions towards its goals are being implemented in coordination with the Philadelphia Water Department (PWD). The Green City, Clean Waters initiative, the city’s nationally recognized stormwater management plan, was signed into action with the U.S. Environmental Protection Agency (EPA) in April 2012. The plan outlines a 25-year strategy to use green infrastructure to protect and improve the city’s watershed. Widespread support for the

  18. Grow Your Own School Leaders: A Case Study of Principal Development in Philadelphia Schools

    ERIC Educational Resources Information Center

    Urban Education Collaborative, 2010

    2010-01-01

    In 2004-05, the School District of Philadelphia (SDP) began a groundbreaking partnership with the Eli Broad Foundation to develop the Academy for Leadership in Philadelphia Schools (ALPS), one of several Broad-funded, alternative principal development programs initiated across the country. The ALPS effort was designed to respond to two challenges:…

  19. A Summary of Four Major Evaluation Reports on Follow Through in Philadelphia, 1975-1976.

    ERIC Educational Resources Information Center

    Goodwin, Judith

    This paper presents summaries of four evaluation reports on Follow Through programs in Philadelphia, grades K-3. Section I compares the reading and mathematics achievement of children from 1971-1976 in the various Follow Through models. Included in the evaluation are the Behavior Analysis, Bank Street, Parent Implemented, Philadelphia Process,…

  20. How Students Are Leading Us: Youth Organizing and the Fight for Public Education in Philadelphia

    ERIC Educational Resources Information Center

    Conner, Jerusha; Rosen, Sonia

    2013-01-01

    Philadelphia has a rich history of high school student activism, stretching back to 1967, when 3,500 Philadelphia students walked out of their schools, marched to the Board of Education, and demanded the addition of black history courses taught by black teachers, the removal of police from high schools, and an increase in the hiring of black…

  1. Strengthening Career and Technical Education and 21st Century Skills in Philadelphia. Executive Summary

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2009

    2009-01-01

    In Spring 2007, the John S. and James L. Knight Foundation awarded funds to the Philadelphia Youth Network (PYN) to undertake an analysis of Career and Technical Education (CTE) in Philadelphia, and to make recommendations on how CTE and other forms of career-connected education could better align with high-wage/high-demand jobs in the regional…

  2. Evaluating the Performance of Philadelphia's Charter Schools. Working Paper WR-550-WPF

    ERIC Educational Resources Information Center

    Zimmer, Ron; Blanc, Suzanne; Gill, Brian; Christman, Jolley

    2008-01-01

    Plagued by long-term poor student outcomes, a number of reforms have been implemented within the Philadelphia School District to improve performance, including the use of charter schools. The number of charter schools in Philadelphia has risen from four to more than 60 over the past decade, and these schools now serve over 30,000 students. Debate…

  3. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Exception for New York and Philadelphia. 37.53... INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and Philadelphia... class representatives”); and Metropolitan Transportation Authority, New York City Transit Authority,...

  4. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Exception for New York and Philadelphia. 37.53... INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and Philadelphia... class representatives”); and Metropolitan Transportation Authority, New York City Transit Authority,...

  5. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Exception for New York and Philadelphia. 37.53... INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and Philadelphia... class representatives”); and Metropolitan Transportation Authority, New York City Transit Authority,...

  6. Addressing the Need for School Age Child Care: A Guide for Philadelphia Elementary School Principals.

    ERIC Educational Resources Information Center

    Mintzer, Janet L.

    The Delaware Valley Child Care Council (DVCCC) developed this booklet to help Philadelphia school principals plan and develop privately run after-school centers in their schools. First, an executive summary documents the need for school-age day care nationwide and in the Philadelphia area. Section I offers guidance on planning a school-age child…

  7. WWC Review of the Report "Philadelphia's Renaissance Schools Initiative: 18 Month Interim Report"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The study reviewed in this report examined the effects of Philadelphia's "Renaissance Schools Initiative" on students in K-8 schools after one year of implementation. Schools were selected for participation based on their School Performance Index (SPI) at the start of the 2010-11 school year. The SPI rates every school in Philadelphia from one to…

  8. Philadelphia's Renaissance Schools: A Report on Start up and Early Implementation

    ERIC Educational Resources Information Center

    Gold, Eva; Good, Deborah; Robertson-Kraft, Claire; Callahan, M. Kate

    2011-01-01

    In April 2009, Superintendent Arlene Ackerman announced her reform plan for the School District of Philadelphia (the District)--"Imagine 2014". Among other major initiatives, "Imagine 2014" laid the groundwork for Philadelphia's Renaissance Schools Initiative. The Renaissance Initiative, set to enter its second year in 2011-12, is an effort to…

  9. A Tale of Two Cities: School Privatization in Philadelphia and Chester

    ERIC Educational Resources Information Center

    Maranto, Robert

    2005-01-01

    In August 2001, the state-run Control Board for the Chester-Upland School District awarded control of nine of their 10 schools to Edison Schools, with little opposition. In contrast, nearby Philadelphia fought state efforts to privatize schools. Finally, on July 31, 2002, the joint state-city Philadelphia School Reform Commission partially…

  10. Time's Up: Applying Teacher Management Skills to Solving Philadelphia's Problems

    ERIC Educational Resources Information Center

    Lax, Zach

    2013-01-01

    Teachers are natural problem solvers, and they should be using this quality to their advantage when it comes to solving the systemic issues that plague Philadelphia's education system. Many of the articles in this issue have already gone into great detail about what is happening in Philadelphia. Torch Lytle has provided a summary of the…

  11. 76 FR 7236 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Boston Stock Exchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-09

    ... Release No. 59858 (May 4, 2009), 74 FR 22191 (May 12, 2009) (SR-NASDAQ-2009-039). Prior to the closing of... COMMISSION Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Boston Stock Exchange... is hereby given that on January 19, 2011, Stock Clearing Corporation of Philadelphia, Inc....

  12. Philadelphia Youth Network Report for the Year Ending December 08: On the Map

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2008

    2008-01-01

    This year's annual report of Philadelphia Youth Network (PYN) celebrates the continuing expansion of opportunities for high-quality education and career preparation available to Philadelphia youth. These opportunities--offered by an ever-growing set of partners and program providers--are present in neighborhoods and communities all across the…

  13. Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome

    SciTech Connect

    Roth, D.G.; Richman, C.M.; Rowley, J.D.

    1980-08-01

    A patient with severe anemia, reticulocytopenia, and erythroid hyperplasia of the bone marrow developed fatal acute nonlymphocytic leukemia after 3 yr. A Philadelphia chromosome with the typical 9/22 translocation was identified by banding techniques in a small number of bone marrow cells throughout the preleukemic phase of the illness (14% to 38% of the metaphases) and during the acute transformation (50%). Granulocytic colony formation in vitro was abnormal in the preleukemic phase. The diagnosis of chronic granulocytic leukemia was excluded on the basis of clinical and laboratory findings. The identification of the Ph/sup 1/ chromosome in this form of chronic myelodysplastic syndrome (preleukemia) provides a new example of a hematologic disorder predisposing to acute leukemia in which this chromosomal abnormality occurs.

  14. Temperature of ground water at Philadelphia, Pennsylvania, 1979- 1981

    USGS Publications Warehouse

    Paulachok, Gary N.

    1986-01-01

    Anthropogenic heat production has undoubtedly caused increased ground-water temperatures in many parts of Philadelphia, Pennsylvania, as shown by temperatures of 98 samples and logs of 40 wells measured during 1979-81. Most sample temperatures were higher than 12.6 degrees Celsius (the local mean annual air temperature), and many logs depict cooling trends with depth (anomalous gradients). Heating of surface and shallow-subsurface materials has likely caused the elevated temperatures and anomalous gradients. Solar radiation on widespread concrete and asphalt surfaces, fossil-fuel combustion, and radiant losses from buried pipelines containing steam and process chemicals are believed to be the chief sources of heat. Some heat from these and other sources is transferred to deeper zones, mainly by conduction. Temperatures in densely urbanized areas are commonly highest directly beneath the land surface and decrease progressively with depth. Temperatures in sparsely urbanized areas generally follow the natural geothermal gradient and increase downward at about that same rate.

  15. Learning From Philadelphia: Topographies of HIV/AIDS Media Assemblages.

    PubMed

    Cartwright, Lisa

    2016-01-01

    For this contribution to the special issue on "Mapping Queer Bioethics," the author employs an array of public health and popular media texts (especially Jonathan Demme's film Philadelphia) to challenge the construction and reconstruction of HIV-positive bodies as sites of bioethical concern. In outlining notions of "digital restoration," the author argues that there has been of late a remapping of the first decade of the HIV/AIDS pandemic through media projects assembled from archived materials. Accordingly, the author suggests that in the first decades of the 2000s, we have witnessed a media-archaeological turn, whereby old materials have been reassembled for commemorative purposes that oftentimes perform a reshaping of the topography of the first decade of the AIDS pandemic. PMID:26642876

  16. Geophysical investigation at Philadelphia Naval Shipyard. Final report,

    SciTech Connect

    Sharp, M.K.

    1992-03-01

    Results of a geophysical investigation at the incinerator site of Philadelphia Naval Shipyard are presented. Following the end of World War II, 50 to 60 pallets of gas cylinders were reportedly buried to the west of the old incinerator at Girard Point. The contents of the cylinders are unknown. Extensive filling operations occurred at Girard Point from 1940 to 1970, resulting in shallow groundwater surface in the area, 2 to 10 ft deep, which would indicate that the cylinders are probably in direct contact with the water surface. The geophysical investigation presented in this report was designed to help alleviate uncertainties produced from previous studies in the area. The geophysical program included electromagnetic induction and magnetic survey methods. The results of the various surveys were integrated, and numerous anomalous areas were interpreted. Anomalies warranting further investigation were presented along with a priority ranking.

  17. Using Local History To Understand National Themes: The Yellow Fever Epidemic in Philadelphia in 1793.

    ERIC Educational Resources Information Center

    Westbury, Susan

    2003-01-01

    Provides background information for a local history project about the 1793 Philadelphia (Pennsylvania) yellow fever outbreak. Offers potential project topics to help students learn about local history and understand life in the eighteenth century United States. (CMK)

  18. Web site helps families cope with childhood illnesses. Children's Hospital of Philadelphia undergoes Internet expansion.

    PubMed

    Rees, Tom

    2002-01-01

    The Children's Hospital of Philadelphia has received accolades for its revised Web site, which provides extensive communications channels for patients and their parents. Also, its intranet streamlines internal communications.

  19. Transgender health: findings from two needs assessment studies in Philadelphia.

    PubMed

    Kenagy, Gretchen P

    2005-02-01

    HIV/AIDS, suicide, violence, and barriers to health care access among transgender people were explored using two needs assessment surveys conducted in Philadelphia in 1997. A total of 182 people responded to a face-to-face interview or self-administered mail survey: 113 male-to-female individuals and 69 female-to-male individuals. About three-fifths of respondents had engaged in unprotected sexual activity during the past 12 months. The risk for HIV infection from unprotected sex was significantly higher among respondents of color than among white respondents. About one-third (30.1 percent) of respondents had attempted suicide. More than half of respondents had been forced to have sex, 56.3 percent had experienced violence in their homes, and 51.3 percent had been physically abused. Twenty-six percent of respondents had been denied medical care because they were transgender. These findings suggest that prevention services that specifically address HIV/AIDS, suicide, and violence among transgender people are urgently needed.

  20. Current treatment concepts of Philadelphia-negative MPN.

    PubMed

    Wolf, D; Rudzki, J; Gastl, G

    2011-01-01

    Since William Dameshek has described the concept of "myeloproliferative disorders (MPD)" by identifying common clinical characteristics (i.e. hemorrhage, thrombosis and leukemic transformation) of polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), the advent of molecular biology has provided substantial molecular insight into the pathobiology of myeloproliferative neoplasia (MPN). Recently, the description of the gain-of-function mutation of JAK2 (JAK2V617F) has been identified in classical Philadelphia (Ph)-negative MPN, thus providing a rational target for novel innovative treatment strategies. In addition, molecular characterization of atypical Ph-negative MPN (e.g. the KITD816V mutation in mastocytosis and PDGF-receptor rearrangements in hypereosinophilic syndromes/chronic eosinophilic leukemia) complement the molecular knowledge of this heterogeneous disease family. Currently, clinical studies testing various JAK2-inhibitors in PV, ET as well as in primary and secondary myelofibrosis (MF) are under way. Interestingly, first data indicate that despite marked clinical activity in terms of spleen size reduction and improvement of constitutional symptoms, these inhibitors might not sufficiently reduce disease burden. Thus, alternative and well established treatment strategies, such as inhibition of thrombocyte aggregation by low dose aspirin, cytotoxics (e.g. hydroxyurea), immuno- and stroma-modifying therapy with interferon, tyrosine kinase inhibitors and, in selected cases, allogeneic stem cell transplantation are still important treatment options for patients suffering from MPN, which will be discussed in detail in this review.

  1. Interpretations of cigarette advertisement warning labels by Philadelphia Puerto Ricans.

    PubMed

    Morris, Nancy; Gilpin, Dawn R; Lenos, Melissa; Hobbs, Renee

    2011-09-01

    This study examined Philadelphia Puerto Ricans' interpretations of the Surgeon General's warnings that appear on cigarette packaging and in advertisements. In-home family focus groups in which participants were asked to comment on magazine cigarette advertisements showed a great variety of interpretations of the legally mandated warning labels. These findings (a) corroborate and add to research in public health and communications regarding the possibility of wide variations in message interpretations and (b) support the call for public health messages to be carefully tested for effectiveness among different social groups. The article's focus on Puerto Ricans addresses the problem of misleading conclusions that can arise from aggregating all Latino subpopulations into one group. The use of a naturalistic setting to examine interpretations of messages about smoking departs from the experimental methods typically used for such research and provides new evidence that even a seemingly straightforward message can be interpreted in multiple ways. Understanding and addressing differences in message interpretation can guide public health campaigns aimed at reducing health disparities. PMID:21534024

  2. Short form Philadelphia Naming Test: Rationale and Empirical Evaluation

    PubMed Central

    Walker, Grant M.; Schwartz, Myrna F.

    2012-01-01

    Purpose To create two matched short forms of the Philadelphia Naming Test (PNT) that yield similar results to the PNT for measuring anomia. Methods Study 1: We first used archived naming data from 94 aphasic individuals to identify which PNT items should be included in the short forms, and the two constructed sets of 30 items, PNT30-A and PNT30-B, were validated using archived data from a separate group of 56 aphasic individuals. Study 2: We then evaluated the reliability of the PNT, PNT30-A, and PNT30-B across independent test administrations with a new group of 25 aphasic individuals selected to represent the full range of naming impairment. Results Study 1: PNT30-A and PNT30-B were found to be internally consistent; and accuracy scores on these subsets of items were highly correlated with the full PNT. Study 2: PNT accuracy was extremely reliable over the span of one week; and independent administrations of PNT30-A and PNT30-B produced similar results to the PNT and to each other. Conclusions The short forms can be used to reliably estimate PNT performance, and the results can be compared to the provided norms. The two matched tests allow for measurement of change in naming ability. PMID:22294412

  3. Health Status of People Undergoing Foreclosure in the Philadelphia Region

    PubMed Central

    Lynch, Julia

    2009-01-01

    Objectives. We assessed the health status of people undergoing mortgage foreclosure in the Philadelphia region to determine if there was a relationship between foreclosure and health. Methods. Participants were recruited in partnership with a mortgage counseling agency. Participants' health status and health care use were compared with a community sample from the 2008 Southeastern Pennsylvania Household Health Survey. We used publicly filed foreclosure records to assess response bias. Results. Of the 250 people recruited, 36.7% met screening criteria for major depression. The foreclosure sample was significantly more likely than the community sample to not have insurance coverage (adjusted odds ratio [AOR] = 2.28; 95% confidence interval [CI] = 1.49, 3.48) and to not have filled a prescription because of cost in the preceding year (AOR = 3.44; 95% CI = 2.45, 4.83). Approximately 9% of the participants reported that their own or a family member's medical condition was the primary reason they were undergoing foreclosure. More than a quarter of those in foreclosure (27.7%) stated that they owed money to medical creditors. Conclusions. Foreclosure affects already-vulnerable populations. Public health practitioners may be able to leverage current efforts to connect homeowners with mortgage counseling agencies to improve health care access. PMID:19696373

  4. The origins of American physical anthropology in Philadelphia.

    PubMed

    Mann, Alan

    2009-01-01

    With its location on a river with easy access to the sea, its central placement between the English speaking colonies to the north and south and its trading connections with the western frontier, there were many reasons Philadelphia became one of the most important towns of prerevolutionary America. In the early 1770s, it was the site of the first meeting organized to deal with the perceived inequities of the British government toward the colonies. It was where Thomas Jefferson wrote much of the Declaration of Independence, whose soaring statements reflecting the Age of Enlightenment spoke of the equality of all men. It was to this debate, centered on just who was included in this declaration that the origins of physical anthropology in America can be traced. Notable men in the early phases of this disputation included Samuel Stanhope Smith and especially Samuel George Morton, considered the founder of American physical anthropology. The American School of Anthropology, which argued for the polygenic origins of human races was substantially founded on Morton's work. Recent accusations that Morton manipulated data to support his racist views would appear unfounded. The publication of The Origin of Species in 1859 and the issuing of the Emancipation Proclamation in 1862-63 effectively ended the earlier debates. By the time of the American Civil War, 1861-65, physical anthropology was beginning to explore other topics including growth and development and anthropometry. PMID:19890866

  5. Public Health and Law Collaboration: The Philadelphia Lead Court Study

    PubMed Central

    Gracely, Ed; Pan, Sarah; Cummings, Curtis; Palermo, Peter; Gould, George

    2013-01-01

    Objectives. We determined whether Philadelphia Lead Court is effective in enforcing lead hazard remediation in the homes of children with elevated blood lead levels. Methods. We created a deidentified data set for properties with an initial failed home inspection (IFHI) for lead hazards from January 1, 1998, through December 31, 2008, and compared compliance rates within the first year and time to compliance for lead hazard remediation between 1998 and 2002 (precourt period) and between 2003 and 2008 (court period). We evaluated predictors of time to compliance. Results. Within 1 year of the IFHI, 6.6% of the precourt and 76.8% of the court cases achieved compliance (P < .001) for the 3764 homes with data. Four years after the IFHI, 18% had attained compliance in the precourt period compared with 83.1% for the court period (P < .001). A proportional hazard analysis found that compliance was 8 times more likely in the court than the precourt period (P < .001). Conclusions. Lead court was more effective than precourt enforcement strategies. Most properties were remediated within 1 year of the IFHI, and time to compliance was significantly reduced. This model court could be replicated in other cities with similar enforcement problems. PMID:23678927

  6. Geohydrology and ground-water resources of Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Paulachok, Gary N.

    1991-01-01

    The aquifers underlying the 134.6-square-mile city of Philadelphia are divided by the Fall Line into the unconsolidated aquifers (chiefly sand and gravel) of the Coastal Plain and the consolidated-rock aquifers (chiefly schist of the Wissahickon Formation) of the Piedmont. Ground water is present under confined and unconfined conditions. The principal units of the confined-aquifer system are the lower and middle sands of the Potomac-Raritan-Magothy aquifer system. The lower sand unit is the most productive aquifer in Philadelphia. The median yield of wells screened in the lower sand unit is 275 gal/min (gallons per minute), and yields of some wells are as high as 1,350 gal/min. The median specific capacity is 16 (gal/min)/ft (gallons per minute per foot of drawdown). The principal units of the unconsolidated unconfined-aquifer system are the upper sand unit of the Potomac-Raritan-Magothy aquifer system and the informally named Trenton gravel. The median yield of wells tapping these two undifferentiated units is 90 gal/min, and yields of some wells are as high as 1,370 gal/min. The median specific capacity is 12 (gal/min)/ft. The consolidated unconfined-aquifer system consists mainly of the Wissahickon Formation. The median yield of nondomestic wells that tap the Wissahickon Formation is 45 gal/min, and yields are as high as 350 gal/min. The median specific capacity is 0.5 (gal/min)/ft. Urbanization has considerably modified the hydrologic cycle in Philadelphia. Impervious surfaces have reduced recharge areas and evapotranspiration and have increased direct runoff. Leakage from the water-distribution system, which is supplied from the Delaware and Schuylkill Rivers, was about 60 to 72 Mgal/d (million gallons per day) in 1980. Groundwater infiltration to sewers is estimated to be as much as 135 Mgal/d when the water table is high. The potentiometric surface of the lower sand unit has been lowered substantially by pumping. By 1954, cones of depression were more than

  7. Philadelphia Electric Company's computer replacement lessons learned at Peach Bottom

    SciTech Connect

    Clark, J.M.; O'Hara, J.

    1989-01-01

    The current regulatory climate continues to prod today's nuclear utilities toward safer and more reliable operation of their plants. U.S. Nuclear Regulatory Commission guides NUREG-0660, NUREG-0696, and Supplement I to NUREG-0737 have all set forth increased requirements for plant monitoring. In response, the industry has looked at their existing plant computer systems as targets for enhancement or upgrade. This external pressure is nearly matched by the increasing demands made on existing computer systems by utility engineering and operations departments. The longer utilities postpone this evolution, the more likely they are to replace the entire system rather than upgrade the existing one. The older systems become harder to maintain and eventually are technically inferior to new systems, which have benefited from advances in computer technology in recent years. Enhancements become less economically advantageous than system replacements as the spread in technology widens. The object of this paper is to describe the Plant Process Computer Replacement Project at Philadelphia Electric Company's (PECo's) Peach Bottom Atomic Power Station. This paper explores (a) the impact on the plant, (b) the design and engineering services required, and (c) the planning and communication essential to a successful computer replacement project.

  8. Reptile neoplasia at the Philadelphia Zoological Garden, 1901-2002.

    PubMed

    Sykes, John M; Trupkiewicz, John G

    2006-03-01

    A retrospective study of neoplasia in reptiles held at the Philadelphia Zoological Garden was conducted. A total of 3,684 original necropsy reports for the period 1901-2002 were reviewed and revealed 86 cases of neoplasia. Original glass slides or re-cuts from paraffin-embedded tissue blocks were examined for confirmation of the original diagnosis. At necropsy, a total of six neoplasms were identified in six of 490 chelonians (1.2%), 22 neoplasms in 19 of 736 lizards (3.0%), and 58 neoplasms in 53 of 1,835 snakes (2.9%). An additional 12 neoplasms were found in biopsies of one turtle and 10 snakes. In the chelonians, all the neoplasms were seen in turtles, four of six tumors were malignant (66%) and no organ predilection was noted. For lizards, the liver was the most commonly affected organ, with 7 of 22 primary neoplasms (31%). Multiple tumor types were identified in three lizards (15%), metastasis occurred in five cases (25%), and malignant tumors were identified in 16 cases (73%). In snakes, the liver was most frequently affected by neoplasia at necropsy, with 13 of 58 primary neoplasms (22%); multiple types of neoplasm were identified in five cases (10%) and metastasis in six (9%); and 42 tumors (80%) were diagnosed as malignant. When biopsies were included for snakes, however, the skin was the most commonly affected organ, with 17 of 69 neoplasms (24%). One of five lizards (20%) and four of six snakes (66%) with metastasis also had a second primary neoplasm. Since 1967, the incidence of lizard neoplasia has increased from 0.7% to 5.9%, and snake neoplasia has increased from 2.6% to 9.3%.

  9. Increased mortality in Philadelphia associated with daily air pollution concentrations

    SciTech Connect

    Schwartz, J.; Dockery, D.W. )

    1992-03-01

    Cause-specific deaths by day for the years 1973 to 1980 in Philadelphia, Pennsylvania, were extracted from National Center for Health Statistics mortality tapes. Death from accidents (International Classification of Disease, Revision 9 greater than or equal to 800) and deaths outside of the city were excluded. Daily counts of deaths were regressed using Poisson regression on total suspended particulate (TSP) and/or SO2 on the same day and on the preceding day, controlling for year, season, temperature, and humidity. A significant positive association was found between total mortality (mean of 48 deaths/day) and both TSP (second highest daily mean, 222 micrograms/m3) and SO2 (second highest daily mean, 299 micrograms/m3). The strongest associations were found with the mean pollution of the current and the preceding days. Total mortality was estimated to increase by 7% (95% CI, 4 to 10%) with each 100-micrograms/m3 increase in TSP, and 5% (95% CI, 3 to 7%) with each 100-micrograms/m3 increase in SO2. When both pollutants were considered simultaneously, the SO2 association was no longer significant. Mortality increased monotonically with TSP. The effect of 100 micrograms/m3 TSP was stronger in subjects older than 65 yr of age (10% increase) compared with those younger than 65 yr of age (3% increase). Cause-specific mortality was also associated with a 100-micrograms/m3 increase in TSP: chronic obstructive pulmonary disease (ICD9 490-496), +19% (95% CI, 0 to 42%), pneumonia (ICD9 480-486 and 507), +11% (95% CI, -3 to +27%), and cardiovascular disease (ICD9 390-448), +10% (95% CI, 6 to 14%). These results are somewhat higher than previously reported associations, and they add to the body of evidence showing that particulate pollution is associated with increased daily mortality at current levels in the United States.

  10. Diversity of breakpoints of variant Philadelphia chromosomes in chronic myeloid leukemia in Brazilian patients

    PubMed Central

    Chauffaille, Maria de Lourdes Lopes Ferrari; Bandeira, Ana Carolina de Almeida; da Silva, Aline Schiavoni Guarnieri

    2014-01-01

    Background Chronic myeloid leukemia is a myeloproliferative disorder characterized by the Philadelphia chromosome or t(9;22)(q34.1;q11.2), resulting in the break-point cluster region-Abelson tyrosine kinase fusion gene, which encodes a constitutively active tyrosine kinase protein. The Philadelphia chromosome is detected by karyotyping in around 90% of chronic myeloid leukemia patients, but 5–10% may have variant types. Variant Philadelphia chromosomes are characterized by the involvement of another chromosome in addition to chromosome 9 or 22. It can be a simple type of variant when one other chromosome is involved, or complex, in which two or more chromosomes take part in the translocation. Few studies have reported the incidence of variant Philadelphia chromosomes or the breakpoints involved among Brazilian chronic myeloid leukemia patients. Objective The aim of this report is to describe the diversity of the variant Philadelphia chromosomes found and highlight some interesting breakpoint candidates for further studies. Methods the Cytogenetics Section Database was searched for all cases with diagnoses of chronic myeloid leukemia during a 12-year period and all the variant Philadelphia chromosomes were listed. Results Fifty (5.17%) cases out of 1071 Philadelphia-positive chronic myeloid leukemia were variants. The most frequently involved chromosome was 17, followed by chromosomes: 1, 20, 6, 11, 2, 10, 12 and 15. Conclusion Among all the breakpoints seen in this survey, six had previously been described: 11p15, 14q32, 15q11.2, 16p13.1, 17p13 and 17q21. The fact that some regions get more frequently involved in such rare rearrangements calls attention to possible predisposition that should be further studied. Nevertheless, the pathological implication of these variants remains unclear. PMID:25638762

  11. Aerosol acidity characterization of large metropolitan areas: Pilot and planning for Philadelphia

    SciTech Connect

    Waldman, J.M.; Koutrakis, P.; Burton, R.; Wilson, W.E.; Purdue, L.J.

    1993-01-01

    The report described the EPA's multi-year program to investigate the specific issues surrounding human exposures to aerosol activity. Philadelphia, a large metropolitan area in the heart of the northeastern seaboard afflicted with photochemical regional smog during the summertime, was chosen as the first city in the program. A pilot study of ambient concentrations was conducted in July 1991. An annular denuder system (ADS) sampler was operated for two weeks near downtown Philadelphia, with a second unit operated in central, suburban New Jersey, the same location of measurements in past years. The Philadelphia site was found to have higher concentrations of most major aerosol species, ammonia and acidic particles than in New Jersey, showing that aerosol neutralization within the urban center will not necessarily totally eliminate acidic particle exposures.

  12. Student Achievement in Privately Managed and District-Managed Schools in Philadelphia Since the State Takeover. Research Brief

    ERIC Educational Resources Information Center

    Gill, Brian; Zimmer, Ron; Christman, Jolley; Blanc, Suzanne

    2007-01-01

    Following a state takeover of the Philadelphia public schools in 2002, 45 schools were turned over to private managers, making Philadelphia the site of the nation's largest experiment in the private management of public schools. This study examines achievement effects in the privately managed schools, as well as in schools with district-led…

  13. Un-Leaded Only: Toward a Safer City for Children. A 2002 Report on Childhood Lead Paint Poisoning in Philadelphia.

    ERIC Educational Resources Information Center

    McCauley, Colleen; Yanoff, Shelly D.; Fynes, Steven E.

    As part of its work in improving the lives and life changes of children in the Philadelphia region, the Philadelphia Citizens for Children and Youth examined the problem of local childhood lead paint poisoning. This report describes their efforts, beginning with a description of the impact of lead poisoning on children's health and a discussion of…

  14. The Organization of Work, Schooling and Family Life in Philadelphia, 1838-1920.

    ERIC Educational Resources Information Center

    Katz, Michael B.; And Others

    Thirteen papers which analyze the relations of work, schooling and family life in Philadelphia, Pennsylvania, from 1838 to 1920, are provided in this report. The papers (and their authors) are the following: (1) "The Transition to Adulthood Among White Philadelphians, 1850-1880" (Michael B. Katz and John Modell); (2) "Work, Household, and the…

  15. What Love Can Do: A Brief History of Quaker Education in Philadelphia.

    ERIC Educational Resources Information Center

    Kashatus, William C., III

    1994-01-01

    William Penn understood that many colonial settlers would not be members of the Religious Society of Friends, so he tried to ensure the practice of Quaker ideals by establishing a compulsory, universal school system embodying the values of community, equality, pacifism, and simplicity. After 300 years, the Philadelphia Yearly Meeting's Committee…

  16. Temple University Persistence Rates for Community College of Philadelphia Transfer Students. Report #118.

    ERIC Educational Resources Information Center

    Philadelphia Community Coll., PA. Office of Institutional Research.

    Temple University has been the transfer institute most frequently attended by Community College of Philadelphia graduates and former students. This report provides short and long-term persistence rates of college students who transfer to Temple University (Pennsylvania). During fall semesters between 1988 and 1998, 22,248 students were admitted to…

  17. Community College of Philadelphia Institutional Effectiveness, 2000: A College Report Card. IR Report #119.

    ERIC Educational Resources Information Center

    Philadelphia Community Coll., PA. Office of Institutional Research.

    This document discusses the institutional self-evaluation process at the Community College of Philadelphia (CCP), examining the college-wide performance indicators that measured CCP's effectiveness. Five broad areas of institutional effectiveness are covered in this report: workforce development; transfer preparation; student persistence, goal…

  18. Turning It around: A Collective Effort to Understand and Resolve Philadelphia's Dropout Crisis

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2006

    2006-01-01

    Today and every day, in neighborhoods and communities throughout Philadelphia, young people are making decisions that will change their lives forever. Some will decide to stay in school, graduate, and prepare themselves for college and careers. Others, who left school without a diploma, will summon the courage to seek out educational programs they…

  19. Uneven Playing Field: Demographic Differences and High School "Choice" in Philadelphia. Policy Brief

    ERIC Educational Resources Information Center

    Research for Action, 2010

    2010-01-01

    Every fall, eighth graders participate in the School District of Philadelphia's high school application and admissions process, vying for spots in a tiered system of public high schools across the city. This policy brief looks at disparities in the students who are successful in exercising school "choice" in the District's high school selection…

  20. 78 FR 75902 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Philadelphia County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-13

    ... (CAA) for nitrogen oxides (NO X ) and volatile organic compounds (VOC) under the 1997 8-hour ozone national ambient air quality standard (NAAQS). EPA's conditional approval of Philadelphia County's 1997 8... compounds. Authority: 42 U.S.C. 7401 et seq. Dated: November 29, 2013. W.C. Early, Acting...

  1. 75 FR 80568 - Proposed Modification of the Philadelphia, PA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... Philadelphia, PA (75 FR 74127). The name and phone number of the person to contact for further information has subsequently been changed. This action provides the correct information. Correction In notice of meetings FR Doc. 2010-30085, as published on November 30, 2010 (75 FR 74127) on page 74127, column two, make...

  2. Assessing Residential Segregation among Medicaid Recipients with Psychiatric Disability in Philadelphia

    ERIC Educational Resources Information Center

    Metraux, Stephen; Caplan, Joel M.; Klugman, Dutch; Hadley, Trevor R.

    2007-01-01

    This study assesses the extent of residential segregation among 15,246 people diagnosed with psychiatric disabilities and receiving Medicaid (MA) in Philadelphia, and an identically sized group of MA recipients serving as matched controls. Results indicate that overall levels of residential segregation among this group were modest at their most…

  3. The Assessment of Present-Moment Awareness and Acceptance: The Philadelphia Mindfulness Scale

    ERIC Educational Resources Information Center

    Cardaciotto, LeeAnn; Herbert, James D.; Forman, Evan M.; Moitra, Ethan; Farrow, Victoria

    2008-01-01

    The purpose of this project was to develop a bidimensional measure of mindfulness to assess its two key components: present-moment awareness and acceptance. The development and psychometric validation of the Philadelphia Mindfulness Scale is described, and data are reported from expert raters, two nonclinical samples (n = 204 and 559), and three…

  4. QUANTITATION, DETECTION AND MEASUREMENT PRECISION OF ORGANIC MOLECULAR MARKERS IN URBAN PARTICULATE MATTER FROM PHILADELPHIA, PA

    EPA Science Inventory

    This work focuses on analysis of organic molecular markers in airborne particulate matter (PM) by Gas Chromatography/Ion Trap Mass Spectrometry (GC/IT MS). The particulate samples used in the method development were collected as PM10 in metropolitan Philadelphia during...

  5. Development and Simulation Testing of a Computerized Adaptive Version of the Philadelphia Naming Test

    ERIC Educational Resources Information Center

    Hula, William D.; Kellough, Stacey; Fergadiotis, Gerasimos

    2015-01-01

    Purpose: The purpose of this study was to develop a computerized adaptive test (CAT) version of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996), to reduce test length while maximizing measurement precision. This article is a direct extension of a companion article (Fergadiotis, Kellough, & Hula, 2015),…

  6. 78 FR 3482 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of Proposed Rule Change With Respect to the Amendment of the By-Laws of Its Parent Corporation, The NASDAQ...

  7. The Loft Building as a School House: A Study for the School District of Philadelphia.

    ERIC Educational Resources Information Center

    Murphy, Levy and Wurman, Architects, Philadelphia, PA.

    The Philadelphia Board of Education has begun to consider the purchase and conversion of commercial and industrial structures for use as teaching facilities. One such building, a six-story fireproof loft building, has been purchased for this purpose. This study investigates the possibilities and limitations of conversion and points up the…

  8. ASSOCIATIONS BETWEEN PARTICULATE MATTER COMPONENTS AND DAILY MORTALITY AND MORBIDITY IN PHILADELPHIA, PA

    EPA Science Inventory

    In evaluating the health risks from particulate matter (PM), the question remains as to which component(s) of PM are most harmful. We investigated this issue using PM mass, PM constituents, mortality, and the elderly hospital admission data in Philadelphia, PA. Daily paired PM...

  9. Coordination of Organic Curriculum Development in the School District of Philadelphia, Pennsylvania. Final Report.

    ERIC Educational Resources Information Center

    Love, George H.

    This document describes the efforts of program administrators to implement an organic curriculum in a Philadelphia, Pennsylvania, high school. The chief program administrator coordinated the activities of eight advisory subcommittees, curriculum development personnel, staff development, and community relations. Organic curriculum is a learner-…

  10. 78 FR 76779 - Proposed Modification of the Philadelphia, PA, Class B Airspace Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... May 9, 2013, the FAA published a final rule modifying the Philadelphia Class B airspace area (78 FR..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation... The Trade Agreements Act of 1979 (Pub. L. 96-39), as amended by the Uruguay Round Agreements Act...

  11. A Philadelphia Story: Building Civic Capacity for School Reform in a Privatizing System

    ERIC Educational Resources Information Center

    Gold, Eva; Simon, Elaine; Cucchiara, Maia; Mitchell, Cecily; Riffer, Morgan

    2007-01-01

    This report was undertaken to assess the state of civic capacity for education reform in Philadelphia. It challenges community and civic sectors of the city to put aside individual interests and work together to mobilize resources to pursue the collective good of public school improvement. The report demonstrates that many of the elements…

  12. What Works Clearinghouse Quick Review: "Philadelphia's Renaissance Schools Initiative: 18 Month Interim Report"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The study examined the effectiveness of Philadelphia's Renaissance Schools Initiative after one year of implementation. The Renaissance Schools Initiative, which began in the 2010-11 school year, aimed at improving low-performing schools by providing new management, additional resources, and new educational strategies. The study reported that…

  13. Building with Benchmarks: The Role of the District in Philadelphia's Benchmark Assessment System

    ERIC Educational Resources Information Center

    Bulkley, Katrina E.; Christman, Jolley Bruce; Goertz, Margaret E.; Lawrence, Nancy R.

    2010-01-01

    In recent years, interim assessments have become an increasingly popular tool in districts seeking to improve student learning and achievement. Philadelphia has been at the forefront of this change, implementing a set of Benchmark assessments aligned with its Core Curriculum district-wide in 2004. In this article, we examine the overall context…

  14. The Structure of the Philadelphia Geriatric Center Morale Scale: A Reinterpretation.

    ERIC Educational Resources Information Center

    Liang, Jersey; Bollen, Kenneth A.

    1983-01-01

    Examines the structure of the Philadelphia Geriatric Center (PGC) Morale Scale using a multiple indicator structural equation model. Based on the 1968 National Senior Citizens Survey, the model is consistently replicated across four subsamples. The claim that the PGC Morale Scale is multidimensional is only appropriate for first-order factors.…

  15. Reproducibility of the WHO histological criteria for the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms.

    PubMed

    Gianelli, Umberto; Bossi, Anna; Cortinovis, Ivan; Sabattini, Elena; Tripodo, Claudio; Boveri, Emanuela; Moro, Alessia; Valli, Riccardo; Ponzoni, Maurilio; M Florena, Ada; F Orcioni, Giulio; Ascani, Stefano; Bonoldi, Emanuela; Iurlo, Alessandra; Gugliotta, Luigi; Franco, Vito

    2014-06-01

    This study, performed on behalf of the Italian Registry of Thrombocythaemias (Registro Italiano Trombocitemie), aimed to test the inter-observer reproducibility of the histological parameters proposed by the WHO classification for the diagnosis of the Philadelphia chromosome-negative myeloproliferative neoplasms. A series of 103 bone marrow biopsy samples of Philadelphia chromosome-negative myeloproliferative neoplasms consecutively collected in 2004 were classified according to the WHO criteria as follows: essential thrombocythaemia (n=34), primary myelofibrosis (n=44) and polycythaemia vera (n=25). Two independent groups of pathologists reviewed the bone marrow biopsies. The first group was asked to reach a collegial 'consensus' diagnosis. The second group reviewed individually all the cases to recognize the main morphological parameters indicated by the WHO classification and report their results in a database. They were subsequently instructed to individually build a 'personal' diagnosis of myeloproliferative neoplasms subtype just assembling the parameters collected in the database. Our results indicate that high levels of agreement (≥70%) have been reached for about all of the morphological features. Moreover, among the 18 evaluated histological features, 11 resulted statistically more useful for the differential diagnosis among the different Philadelphia chromosome-negative myeloproliferative neoplasms. Finally, we found a high percentage of agreement (76%) between the 'personal' and 'consensus' diagnosis (Cohen's kappa statistic >0.40). In conclusion, our results support the use of the histological criteria proposed by the WHO classification for the Philadelphia chromosome-negative myeloproliferative neoplasms to ensure a more precise and early diagnosis for these patients.

  16. Elements of Success: WorkReady Philadelphia Program Year 2011-2012 Report

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2012

    2012-01-01

    What does it take to deliver WorkReady Philadelphia's high-quality career-connected programming? In short, it's all about the "elements"--those essential components of the system that combine to produce success for young people. This 2011-12 WorkReady report reinforces this theme by using visual aspects of the "Periodic Table of Elements", which…

  17. 78 FR 40399 - Safety Zone; Fifth Coast Guard District Fireworks Displays, Delaware River; Philadelphia, PA.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Fifth Coast Guard District Fireworks Displays, Delaware River; Philadelphia, PA. AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is temporarily changing the enforcement date of a safety zone for one...

  18. Neighborhoods, Troubles, and Schooling: The Ecology of Philadelphia's Public Schools. Publication Series 95-13.

    ERIC Educational Resources Information Center

    Yancey, William L.; And Others

    The relationship between the educational character of Philadelphia's public schools (Pennsylvania) and the communities in which they are embedded was studied using information from the 1990 Federal Census and the city's police and health departments. The characteristics of the city's neighborhoods are described, and schools are located in their…

  19. 75 FR 25285 - John Heinz National Wildlife Refuge at Tinicum, Philadelphia and Delaware Counties, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ...: Electronic Mail: fws.gov ">northeastplanning@ fws.gov . Include ``John Heinz NWR CCP'' in the subject line of...., Philadelphia, PA 19153; phone: (215) 365-3118; electronic mail: gary--stolz(copyright) fws.gov . SUPPLEMENTARY... CONTACT). You may also send comments anytime during the planning process by mail, electronic mail,...

  20. Spatial analysis of volatile organic compounds in South Philadelphia using passive samplers

    EPA Science Inventory

    Select volatile organic compounds (VOCs) were measured in the vicinity of a petroleum refinery and related operations in South Philadelphia, Pennsylvania, USA, using passive air sampling and laboratory analysis methods. Two-week, time-integrated samplers were deployed at 17 sites...

  1. 77 FR 45290 - Proposed Modification of Class B Airspace Area; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... established the Philadelphia, PA, Terminal Control Area (TCA) with an effective date of March 27, 1975 (39 FR 43710). In 1993, as part of the Airspace Reclassification Final Rule (56 FR 65638), the term ``terminal control area'' was replaced by ``Class B airspace area.'' The primary purpose of Class B airspace is...

  2. SEASONAL ABUNDANCE OF ORGANIC MOLECULAR MARKERS IN URBAN PARTICULATE MATTER FROM PHILADELPHIA, PA

    EPA Science Inventory

    Organic molecular markers were measured in airborne particulate matter (PM10) from the City of Philadelphia North Broad Street air quality monitoring site to identify the seasonal abundances of key tracer compounds together with their dominant sources. Daily PM10...

  3. Which School Resources Help Learning? Efficiency and Equity in Philadelphia Public Schools. Business Review.

    ERIC Educational Resources Information Center

    Summers, Anita A.; Wolfe, Barbara L.

    This report describes a study of the impact of certain educational inputs on the rate of growth in achievement for various types of students in Philadelphia's public schools. Data for the analysis were drawn from pupil histories of 627 students from 103 elementary schools, 553 students from 42 junior high schools, and 716 students from 5 senior…

  4. Osage Avenue Is Burning: The Influence of Race upon Crisis Public Relations in Philadelphia.

    ERIC Educational Resources Information Center

    Bishop, Robert L.; Boles, Wendy Gotchel

    A study examined public relations aspects of the police confrontation and bombing of the revolutionary Black group, MOVE, in Philadelphia, in which 11 persons were killed, 250 were left homeless, and 61 homes were destroyed. It explored if and how race affected the crisis and whether Black media and general media were treated differently. City…

  5. Reforming the Eighth-Grade Student Assignment Process for the Philadelphia Public Schools.

    ERIC Educational Resources Information Center

    Johnson, Michael P.

    The eighth grade student assignment project, an initiative of the School District of Philadelphia, assigns students to high school academic programs based on student preferences, academic preparation, program capacity, and desegregation requirements. These programs, called small learning communities (SLCs), emphasize areas such as design and…

  6. Principals' Hiring of Teachers in Philadelphia Schools: A Research Report on Improving Teacher Quality

    ERIC Educational Resources Information Center

    Ramirez, Heidi A.; Schofield, Lynne Steuerle; Black, Melissa

    2009-01-01

    The School District of Philadelphia (SDP), like many other urban school districts, struggles to increase its hiring and retention of experienced and highly qualified teachers in its low-performing/high-need schools. Toward the goal of improving teacher quality and the experience balance, particularly in hard-to-staff schools, the Philadelphia…

  7. Extension, Communities, and Schools: Results of a Collaborative Forestry Education Project in Philadelphia.

    ERIC Educational Resources Information Center

    Broussard, Shorna R.; Jones, Stephen B.

    2001-01-01

    Penn State Extension, Philadelphia community leaders, school district administrators, and teachers developed a comprehensive program to teach inner-city youth about forestry and forest management. Evaluation results indicate that students were more knowledgeable about forestry and forest management; teachers were more likely to use natural…

  8. The Launch of the Philadelphia Education Research Consortium: Lessons Learned from the First Year of Implementation

    ERIC Educational Resources Information Center

    Shaw, Kate

    2016-01-01

    The Philadelphia Education Research Consortium (PERC) was launched in July 2014 as an innovative place-based consortium of educational research partners from multiple sectors. Its primary objective is to provide research and analyses on some of the city's most pressing education issues. As such, PERC's research agenda is driven by both traditional…

  9. PM CONSTITUENT ROLES IN MASS ASSOCIATIONS WITH HEALTH EFFECTS IN PHILADELPHIA, PA

    EPA Science Inventory

    An environmental and health database was constructed for Philadelphia, PA for the period 1992-1995 in order to assess the importance of PM components in mass associations with adverse health effects. PM data were collected by Harvard University for the U.S. EPA. Daily measureme...

  10. A Survey of Automotive Mechanics Programs in the Philadelphia Public Schools. Report No. 8701.

    ERIC Educational Resources Information Center

    Chern, Hermine J.; And Others

    During March and April of 1986, the three members of the Career Education Evaluation Unit of the Philadelphia (Pennsylvania) School District interviewed 29 automotive mechanics teachers working at nine comprehensive high schools, two vocational technical schools, and two skills centers. The interviews focused on the implementation of standardized…

  11. "Welcome to Philadelphia": An Original Dramatization of Life in the 1780s.

    ERIC Educational Resources Information Center

    Stakes, Mary E.

    Teachers can create an interest in the founding period of U.S. history and present students with an authentic view of this time period through the presentation of this play. The dramatic pretense of the play is that the audience, by their presence, is part of the drama. The audience plays the part of travelers visiting a Philadelphia home in the…

  12. Getting a Feel for the Market: The Use of Privatized School Management in Philadelphia

    ERIC Educational Resources Information Center

    Byrnes, Vaughan

    2009-01-01

    This study evaluates the impact of the privatization of education services in the Philadelphia School District, using an interrupted time series design. The sample observes 88 middle-grades schools, beginning with the 1996-97 school year, and finds that, by 2006, four years postintervention, the achievement growth rate of schools run by…

  13. History, Heritage, and Hearsay: A Children's Guide to Ethnic South and Southwest Philadelphia.

    ERIC Educational Resources Information Center

    D'Amico, Joseph J.; Newcombe, Ellen

    This guide for elementary students will help them learn about five of South and Southwest Philadelphia's ethnic groups and examine their own ethnic heritage. These groups are: Afro Americans, Irish Americans, Italian Americans, Jewish Americans, and Polish Americans. The guide has different sections. "Hearsay" sections contain short stories based…

  14. Contracting Out Schools: The First Year of the Philadelphia Diverse Provider Model

    ERIC Educational Resources Information Center

    Bulkley, Katrina; Mundell, Leah; Riffer, Morgan

    2004-01-01

    Educators nationwide focused on Philadelphia in the summer of 2001 as politicians and policy makers explored the possibility of a state takeover of the city's school system, a seismic power shift that would produce the largest privatization of a public school district in American history. The findings reported in this document are based on…

  15. Sowing City Schools: Teachers and Garden Education in Havana and Philadelphia

    ERIC Educational Resources Information Center

    Bucher, Katie Ann

    2012-01-01

    This dissertation examines how pedagogies of sustainability are embedded in socio-cultural contexts and policy structures and driven by the localized actions of teachers. Through a comparative case study in two cities with extensive and varied school garden programs, Havana and Philadelphia, this dissertation analyzes the roles, understandings,…

  16. Acute, fatal Sarcocystis calchasi-associated hepatitis in Roller pigeons (Columbia livia f. dom.) at Philadelphia Zoo

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Four Roller pigeons (Columba livia f. dom.) at the Philadelphia Zoo died suddenly. Necropsy examination revealed macroscopic hepatitis. Microscopically, the predominant lesions were in liver, characterized with necrosis and mixed cell inflammatory response. Sarcocystis calchasi-like schizonts and fr...

  17. Spatial and temporal patterns in Cimex lectularius (Hemiptera: Cimicidae) reporting in Philadelphia, PA.

    PubMed

    Mabud, Tarub S; Barbarin, Alexis M; Barbu, Corentin M; Levy, Katelyn H; Edinger, Jason; Levy, Michael Z

    2014-01-01

    We analyzed a comprehensive telephone log of pest infestation reports to assess the spatial and temporal trends in Cimex lectularius L. (bed bug) reporting throughout Philadelphia, PA. Citywide spatial analyses of reports from September 2011 to June 2012 revealed several statistically significant bed bug hotspots. However, these were small and diffuse. Temporal analyses of reports from December 2008 to May 2011 detected prominent seasonality in bed bug reporting, peaking in August and reaching a nadir in February each year. Controlling for seasonal cycling, the number of bed bug reports in Philadelphia increased steadily at a rate of approximately 4.5% per month (or 69.45% per year) from December 2008 to May 2011. While it may be difficult to spatially target citywide bed bug control measures because of the insects' widespread migration, interventions informed by seasonal trends may enhance efforts to curb the recent increases in urban bed bug populations. PMID:24605452

  18. Heat-related deaths--Philadelphia and United States, 1993-1994.

    PubMed

    1994-07-01

    During June 1994, temperatures across the United States were higher than usual. Since June 13, record high temperatures (above 90 F [32.2 C]) with humidities of 50%-60% have occurred in the northeastern United States (1). During July 1-14, 1993, the eastern United States also experienced a severe heat wave with high temperatures (93 F-101 F [33.9 C-38.3 C]) and high humidity (36%-58%) (2). During July 6-14, 1993, in Philadelphia, medical examiners (MEs) determined 118 deaths were heat-related*. This report describes heat-related deaths that occurred in Philadelphia during 1993 and 1994 and summarizes risk factors for heat-related illness and death. PMID:8208234

  19. Update on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinib.

    PubMed

    Emole, Josephine; Talabi, Taiwo; Pinilla-Ibarz, Javier

    2016-01-01

    Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia chromosome and the bcr-abl gene. The discovery of tyrosine kinase inhibitors (TKIs) revolutionized therapy for CML, such that durable response, increased overall survival, and increased progression-free survival of patients in chronic phase CML is now possible. Due to resistance and intolerance to imatinib, there was need for development of second- and third-generation TKIs for the treatment of CML. This review examines the role of nilotinib, an oral second-generation TKI, in the treatment of Philadelphia positive CML. The pharmacology, efficacy, and safety of nilotinib are critically evaluated. Patient-related issues, including tolerance, drug interactions, and quality of life issues are also examined.

  20. Spatial and Temporal Patterns in Cimex lectularius (Hemiptera: Cimicidae) Reporting in Philadelphia, PA

    PubMed Central

    MABUD, TARUB S.; BARBARIN, ALEXIS M.; BARBU, CORENTIN M.; LEVY, KATELYN H.; EDINGER, JASON; LEVY, MICHAEL Z.

    2014-01-01

    We analyzed a comprehensive telephone log of pest infestation reports to assess the spatial and temporal trends in Cimex lectularius L. (bed bug) reporting throughout Philadelphia, PA. Citywide spatial analyses of reports from September 2011 to June 2012 revealed several statistically significant bed bug hotspots. However, these were small and diffuse. Temporal analyses of reports from December 2008 to May 2011 detected prominent seasonality in bed bug reporting, peaking in August and reaching a nadir in February each year. Controlling for seasonal cycling, the number of bed bug reports in Philadelphia increased steadily at a rate of ≈4.5% per month (or 69.45% per year) from December 2008 to May 2011. While it may be difficult to spatially target citywide bed bug control measures because of the insects’ widespread migration, interventions informed by seasonal trends may enhance efforts to curb the recent increases in urban bed bug populations. PMID:24605452

  1. Assessment of screening, treatment, and prevention of perinatal infections in the Philadelphia birth cohort.

    PubMed

    Jessop, Amy B; Watson, Barbara; Mazar, Rebecca; Andrel, Jocelyn

    2005-01-01

    Certain population groups are at risk for inadequate prenatal care and transmission of perinatal infections. Philadelphia's birth cohort comprises largely at-risk groups and its infant mortality rate is among the nation's highest. This study identifies factors associated with infectious disease screening, treatment, and prevention in Philadelphia. Delivery charts for a probability sample of 550 patients were reviewed. Demographic factors associated with prenatal and delivery care were identified through Pearson chi-square, analysis of variance, and stepwise logistic regression analysis. Nonstandard and incomplete documentation complicated abstraction. Some prenatal care was noted in 95% of the records and screening varied by disease. Factors independently associated with care include maternal race, insurance status, and maternal age. Screening for infections with well-established recommendations (hepatitis B virus, rubella, syphilis) occurred more often than for group B streptococcus, HIV, hepatitis C virus, and varicella. Adoption of standard reporting forms and processes could improve practice and aid in quality improvement efforts and patient communication.

  2. Seizing Opportunities: Genie Tyburski--Ballard Spahr Andrews & Ingersoll, LLP, Philadelphia

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    Genie Tyburski did not set out to be a law librarian. When asked at Drexel's library school what kind of librarian she wanted to be, she was surprised that "a good one" was not one of the options. But six weeks into the semester, she landed a part-time cataloging job at Community Legal Services in Philadelphia; six months later she was the library…

  3. The feasibility of refuse-fired energy generation in Philadelphia, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Christman, W. M., III

    1982-02-01

    The City of Philadelphia presently disposes of 816, 480 megagrams per year (MGY) of residential refuse, with 1 megagram = 10 to the 3rd power hilograms. Alternatives to a base case of continued incineration and landfilling are evaluated. It is assured that the feasibility studies will yield compatible products and will run a uniform economic analysis against the base case, using as inputs the outputs of the feasibility analyses.

  4. Using Multispectral Analysis in GIS to Model the Potential for Urban Agriculture in Philadelphia

    NASA Astrophysics Data System (ADS)

    Dmochowski, J. E.; Cooper, W. P.

    2010-12-01

    In the context of growing concerns about the international food system’s dependence on fossil fuels, soil degradation, climate change, and other diverse issues, a number of initiatives have arisen to develop and implement sustainable agricultural practices. Many seeking to reform the food system look to urban agriculture as a means to create localized, sustainable agricultural production, while simultaneously providing a locus for community building, encouraging better nutrition, and promoting the rebirth of depressed urban areas. The actual impact of such system, however, is not well understood, and many critics of urban agriculture regard its implementation as impractical and unrealistic. This project uses multispectral imagery from United States Department of Agriculture’s National Agricultural Imagery Program with a one-meter resolution to quantify the potential for increasing urban agriculture in an effort to create a sustainable food system in Philadelphia. Color infrared images are classified with a minimum distance algorithm in ArcGIS to generate baseline data on vegetative cover in Philadelphia. These data, in addition to mapping on the ground, form the basis of a model of land suitable for conversion to agriculture in Philadelphia, which will help address questions related to potential yields, workforce, and energy requirements. This research will help city planners, entrepreneurs, community leaders, and citizens understand how urban agriculture can contribute to creating a sustainable food system in a major North American city.

  5. Neighborhood racial composition, social capital and black all-cause mortality in Philadelphia.

    PubMed

    Hutchinson, Rebbeca N; Putt, Mary A; Dean, Lorraine T; Long, Judith A; Montagnet, Chantal A; Armstrong, Katrina

    2009-05-01

    Neighborhood characteristics such as racial composition and social capital have been widely linked to health outcomes, but the direction of the relationship between these characteristics and health of minority populations is controversial. Given this uncertainty, we examined the relationship between neighborhood racial composition, social capital, and black all-cause mortality between 1997 and 2000 in 68 Philadelphia neighborhoods. Data from the U.S. Census, the Philadelphia Health Management Corporation's 2004 Southeast Pennsylvania Community Health Survey, and city vital statistics were linked by census tract and then aggregated into neighborhoods, which served as the unit of analysis. Neighborhood social capital was measured by a summative score of respondent assessments of: the livability of their community, the likelihood of neighbors helping one another, their sense of belonging, and the trustworthiness of their neighbors. After adjustment for the sociodemographic characteristics of neighborhood residents, black age-adjusted all-cause mortality was significantly higher in neighborhoods that had lower proportion of black residents. Neighborhood social capital was also associated with lower black mortality, with the strongest relationship seen for neighborhoods in the top half of social capital scores. There was a significant interaction between racial composition and social capital, so that the effect of social capital on mortality was greatest in neighborhoods with a higher proportion of black residents and the effect of racial composition was greatest in neighborhoods with high social capital. These results demonstrate that age-adjusted all-cause black mortality is lowest in mostly black neighborhoods with high levels of social capital in Philadelphia. PMID:19324485

  6. Phylogenetic Reconstruction of the Legionella pneumophila Philadelphia-1 Laboratory Strains through Comparative Genomics

    PubMed Central

    Ensminger, Alexander W.

    2013-01-01

    Over 20 years ago, two groups independently domesticated Legionella pneumophila from a clinical isolate of bacteria collected during the first recognized outbreak of Legionnaires’ disease (at the 1976 American Legion’s convention in Philadelphia). These two laboratory strains, JR32 and Lp01, along with their derivatives, have been disseminated to a number of laboratories around the world and form the cornerstone of much of the research conducted on this important pathogen to date. Nevertheless, no exhaustive examination of the genetic distance between these strains and their clinical progenitor has been performed thus far. Such information is of paramount importance for making sense of several phenotypic differences observed between these strains. As environmental replication of L. pneumophila is thought to exclusively occur within natural protozoan hosts, retrospective analysis of the domestication and axenic culture of the Philadelphia-1 progenitor strain by two independent groups also provides an excellent opportunity to uncover evidence of adaptation to the laboratory environment. To reconstruct the phylogenetic relationships between the common laboratory strains of L. pneumophila Philadelphia-1 and their clinical ancestor, we performed whole-genome Illumina resequencing of the two founders of each laboratory lineage: JR32 and Lp01. As expected from earlier, targeted studies, Lp01 and JR32 contain large deletions in the lvh and tra regions, respectively. By sequencing additional strains derived from Lp01 (Lp02 and Lp03), we retraced the phylogeny of these strains relative to their reported ancestor, thereby reconstructing the evolutionary dynamics of each laboratory lineage from genomic data. PMID:23717549

  7. Instituting a Smoke-Free Policy for City Recreation Centers and Playgrounds, Philadelphia, Pennsylvania, 2010

    PubMed Central

    Mallya, Giridhar; Dean, Lorraine T.; Rizvi, Amna; Dignam, Leo; Schwarz, Donald F.

    2013-01-01

    Background In the United States, more than 600 municipalities have smoke-free parks, and more than 100 have smoke-free beaches. Nevertheless, adoption of outdoor smoke-free policies has been slow in certain regions. Critical to widespread adoption is the sharing of knowledge about the policy development and implementation process. In this article, we describe our experience in making City of Philadelphia recreation centers and playgrounds smoke-free. Community Context Of the 10 largest US cities, Philadelphia has among the highest rates of adult and youth smoking. Our objectives for an outdoor smoke-free policy included protecting against secondhand smoke, supporting a normative message that smoking is harmful, motivating smokers to quit, and mitigating tobacco-related sanitation costs. Methods The Philadelphia Department of Public Health and the Department of Parks and Recreation engaged civic leaders, agency staff, and community stakeholders in the following steps: 1) making the policy case, 2) vetting policy options and engaging stakeholders, and 3) implementing policy. Near-term policy impacts were assessed through available data sources. Outcome More than 220 recreation centers, playgrounds, and outdoor pools became smoke-free through a combined mayoral executive order and agency regulation. Support for the policy was high. Estimates suggest a policy reach of 3.6 million annual visitors and almost 850 acres of new smoke-free municipal property. Interpretation Localities can successfully implement outdoor smoke-free policies with careful planning and execution. Such policies hold great potential for reducing exposure to secondhand smoke, promoting nonsmoking norms, and providing additional motivation for residents to quit smoking. PMID:23845177

  8. [Control discourses and power relations of yellow fever: Philadelphia in 1793].

    PubMed

    Kim, Seohyung

    2014-12-01

    1793 Yellow fever in Philadelphia was the most severe epidemics in the late 18th century in the United States. More than 10% of the population in the city died and many people fled to other cities. The cause of yellow fever in the United States had close relationship with slaves and sugar in Philadelphia. Sugarcane plantation had needed many labors to produce sugar and lots of Africans had to move to America as slaves. In this process, Aëdes aegypti, the vector of yellow fever had migrated to America and the circumstances of ships or cities provided appropriate conditions for its breeding. In this period, the cause of yellow fever could not be established exactly, so suggestions of doctors became entangled in political and intellectual discourses in American society. There was a critical conflict between Jeffersonian Republicanism and Federalism about the origin and treatment of yellow fever. Benjamin Rush, a Jeffersonian Republican, suggested urban sanitation reform and bloodletting. He believed the infectious disease happened because of unsanitary city condition, so he thought the United States could be a healthy nation by improvement of the public health and sanitation. He would like to cope with national crisis and develop American society on the basis of republicanism. While Rush suggested the improvement of public health and sanitation, the city government of Philadelphia suggested isolation of yellow fever patients and quarantine. City government isolated the patients from healthy people and it reconstructed space of hospital. Also, it built orphanages to take care of children who lost their parents during the epidemic and implemented power to control people put in the state of exception. Of course, city government tried to protect the city and nation by quarantine of every ship to Philadelphia. Control policies of yellow fever in 1793 showed different conflicts and interactions. Through the yellow fever, Jeffersonian Republicanism and Federalism had

  9. Evolving Therapeutic Strategies for the Classic Philadelphia-Negative Myeloproliferative Neoplasms

    PubMed Central

    Kaplan, Jason B.; Stein, Brady L.; McMahon, Brandon; Giles, Francis J.; Platanias, Leonidas C.

    2016-01-01

    Despite the emergence of JAK inhibitors, there is a need for disease-modifying treatments for Philadelphia-negative myeloproliferative neoplasms (MPNs). JAK inhibitors ameliorate symptoms and address splenomegaly, but because of the heterogeneous contributors to the disease process, JAK inhibitor monotherapy incompletely addresses the burden of disease. The ever-growing understanding of MPN pathogenesis has provided the rationale for testing novel and targeted therapeutic agents, as monotherapies or in combination, in preclinical and clinical settings. A number of intriguing options have emerged, and it is hoped that further progress will lead to significant changes in the natural history of MPNs. PMID:26870834

  10. Site handbook: data acquisition system information, passive solar retrofit Automobile Maintenance Facility, City of Philadelphia

    SciTech Connect

    Not Available

    1985-01-01

    Data were collected at the City of Philadelphia's Auto Maintenance Facility using an Aeoloan Kinetics PDL-24 data acquisition system. Instantaneous data readings were recorded each 15 seconds by the microprocessor. These channel readings were then averaged to produce hourly values which were then stored on an audio cassette. The energy saving strategies include: styrofoam and concrete roof coverings; weatherstripping; replacement of north windows with combination insulation and view glazing; PVC strips between heated and unheated areas; gas fired radiant heaters at individual work stations; reduction of the number of light fixtures; and the installation of retrofit window units for radiant solar heating, daylighting, ventilation, glare control and vandalism protection.

  11. Genomic Analysis Reveals Novel Diversity among the 1976 Philadelphia Legionnaires’ Disease Outbreak Isolates and Additional ST36 Strains

    PubMed Central

    Mercante, Jeffrey W.; Morrison, Shatavia S.; Desai, Heta P.; Raphael, Brian H.; Winchell, Jonas M.

    2016-01-01

    Legionella pneumophila was first recognized as a cause of severe and potentially fatal pneumonia during a large-scale outbreak of Legionnaires’ disease (LD) at a Pennsylvania veterans’ convention in Philadelphia, 1976. The ensuing investigation and recovery of four clinical isolates launched the fields of Legionella epidemiology and scientific research. Only one of the original isolates, “Philadelphia-1”, has been widely distributed or extensively studied. Here we describe the whole-genome sequencing (WGS), complete assembly, and comparative analysis of all Philadelphia LD strains recovered from that investigation, along with L. pneumophila isolates sharing the Philadelphia sequence type (ST36). Analyses revealed that the 1976 outbreak was due to multiple serogroup 1 strains within the same genetic lineage, differentiated by an actively mobilized, self-replicating episome that is shared with L. pneumophila str. Paris, and two large, horizontally-transferred genomic loci, among other polymorphisms. We also found a completely unassociated ST36 strain that displayed remarkable genetic similarity to the historical Philadelphia isolates. This similar strain implies the presence of a potential clonal population, and suggests important implications may exist for considering epidemiological context when interpreting phylogenetic relationships among outbreak-associated isolates. Additional extensive archival research identified the Philadelphia isolate associated with a non-Legionnaire case of “Broad Street pneumonia”, and provided new historical and genetic insights into the 1976 epidemic. This retrospective analysis has underscored the utility of fully-assembled WGS data for Legionella outbreak investigations, highlighting the increased resolution that comes from long-read sequencing and a sequence type-matched genomic data set. PMID:27684472

  12. Lessons for providers and hospitals from Philadelphia's obstetric services closures and consolidations, 1997-2012.

    PubMed

    Lorch, Scott A; Martin, Ashley E; Ranade, Richa; Srinivas, Sindhu K; Grande, David

    2014-12-01

    The Affordable Care Act is triggering an increase in hospital consolidation and mergers. How other hospitals respond to these disruptions in supply could influence patient outcomes. We examined the experience of Philadelphia County, Pennsylvania (coterminous with the city of Philadelphia), where thirteen of nineteen hospital obstetric units closed between 1997 and 2012. Between October 2011 and January 2012 we interviewed twenty-three key informants from eleven hospitals (six urban and five suburban) whose obstetric units remained open, to understand how the large number of closures affected their operations. Informants reported having confronted numerous challenges as a result of the obstetric unit closures, including sharp surges in delivery volume and an increase in the proportion of patients with public insurance or no insurance. Informants reported adopting a number of strategies, such as innovative staffing models, to cope with the added demand brought about by the closure of nearby obstetric units. Informants emphasized that interhospital communication could mitigate closures' stresses on the health care system. Our study supports the need for policy makers to anticipate reductions in supply and monitor patient outcomes.

  13. Why support a women's medical college? Philadelphia's early male medical pro-feminists.

    PubMed

    Peitzman, Steven J

    2003-01-01

    The male founders and early faculty of Philadelphia's Woman's Medical College were mostly abolitionist physicians, zealous moralists for whom medical feminism formed only one of the cherished causes they could "manfully" and righteously defend. Male faculty of the late nineteenth century comprised "self-made" men, mostly new specialists, for whom strict sexism probably seemed inconsistent with progressive medicine. For some of these physicians-obviously a small minority-defending medical women and breaking the barriers of fraternity could be consistent with "manly" responsibility. The outcome of the collaboration of women and the dissident men physicians in nineteenth-century Philadelphia amounted to another seeming paradox: the majority of the male medical profession, both locally and nationally, tyrannically hindered women's entry into the profession, yet medicine opened its doors in advance of law and the clergy; and where this first occurred, such as in the community centered on Woman's Medical College, a novel gender rearrangement arose based on collaboration and friendship. PMID:14523261

  14. Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation

    PubMed Central

    Singh, Yadvinder; Bali, Chamandeep

    2013-01-01

    Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells and is typically well treated with combination chemotherapy, with a remission state after 5 years of 94% in children and 30–40% in adults. To establish how aggressive the disease is, further chromosome testing is required to determine whether the cancer is myeloblastic and involves neutrophils, eosinophils or basophils, or lymphoblastic involving B or T lymphocytes. This case study is on a 14-year-old patient diagnosed with a very aggressive form of ALL (positive for the Philadelphia chromosome mutation). A standard bone marrow transplant, aggressive chemotherapy and radiation therapy were revoked, with treatment being deemed a failure after 34 months. Without any other solutions provided by conventional approaches aside from palliation, the family administered cannabinoid extracts orally to the patient. Cannabinoid resin extract is used as an effective treatment for ALL with a positive Philadelphia chromosome mutation and indications of dose-dependent disease control. The clinical observation in this study revealed a rapid dose-dependent correlation. PMID:24474921

  15. The Plight of the "Able Student": Ruth Wright Hayre and the Struggle for Equality in Philadelphia's Black High Schools, 1955-1965

    ERIC Educational Resources Information Center

    Delmont, Matthew

    2010-01-01

    This article features Ruth Wright Hayre, Philadelphia's first black high school teacher and principal whose work at William Penn High School for Girls became a model for counseling and motivation programs at other majority-black high schools in Philadelphia, expanding educational and career opportunities for thousands of "able" students. Through…

  16. 1974-75 Philadelphia City-Wide Testing Program; February 1975 Achievement Testing Program. School Performance Distributions: Kindergarten through Grade Twelve.

    ERIC Educational Resources Information Center

    Grosswald, Jules

    This is a report of pupil performance in Philadelphia schools based upon the February 1975 Philadelphia City-Wide Testing Program involving all pupils in kindergarten through grade 12. School performance distributions show the combined percentages of pupils in each school scoring within various national percentile rank ranges. The performance…

  17. Young People Take Their Rightful Places as Full and Contributing Members of a World Class Workforce: Philadelphia Youth Network Annual Report 2006

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2006

    2006-01-01

    The title of this year's annual report has particular meaning for all of the staff at the Philadelphia Youth Network. The phrase derives from Philadelphia Youth Network's (PYN's) new vision statement, developed as part of its recent strategic planning process, which reads: All of our city's young people take their rightful places as full and…

  18. Examination of the Philadelphia Geriatric Morale Scale as a Subjective Quality-of-Life Measure in Elderly Hong Kong Chinese

    ERIC Educational Resources Information Center

    Wong, Eric; Woo, Jean; Hui, Elsie; Ho, Suzanne C.

    2004-01-01

    Purpose: We examine the psychometric properties of the Philadelphia Geriatric Morale Scale (PGMS) in an elderly Chinese population in Hong Kong. Design and Methods: The study consisted of two cohorts: (a) 759 participants aged 70 years and older living in the community who were recruited as part of a territory-wide health survey and interviewed in…

  19. Correlates to Human Papillomavirus Vaccination Status and Willingness to Vaccinate in Low-Income Philadelphia High School Students

    ERIC Educational Resources Information Center

    Bass, Sarah B.; Leader, Amy; Shwarz, Michelle; Greener, Judith; Patterson, Freda

    2015-01-01

    Background: Little is known about the correlates of human papillomavirus (HPV) vaccination or willingness to be vaccinated in urban, minority adolescents. Methods: Using responses to the 2013 Youth Risk Behavior Survey in Philadelphia, a random sample of high schools provided weighted data representing 20,941 9th to 12th graders. Stratified by…

  20. Over 30 Years of Language-in-Education Policy and Planning: Potter Thomas Bilingual School in Philadelphia.

    ERIC Educational Resources Information Center

    Cahnmann, Melisa

    1998-01-01

    Changes in politics, the economy, demographics, and local leadership all led to the establishment of the Potter Thomas Bilingual School in Philadelphia in 1969. Describes the school's history; how it created, implemented, and sustained language policies within its personnel, curriculum, evaluation, and community policies; and present and future…

  1. Group-specific human granulocyte antigens on a chronic myelogenous leukemia cell line with a Philadelphia chromosome marker.

    PubMed

    Drew, S I; Terasaki, P I; Billing, R J; Bergh, O J; Minowada, J; Klein, E

    1977-05-01

    Group-specific human granulocyte antigens are serologically detectable with granulocytotoxic-positive human alloantisera on a cell line, K562, of chronic myelogenous leukemia origin which bears a Philadelphia chromosomal marker. The same cell line lacks serologically detectable HLA, B2 microglobulin, and B-lymphocyte antigens. Granulocyte antigens are important cell markers for cell lines of suspected myeloid lineage.

  2. A POPULATION EXPOSURE MODEL FOR PARTICULATE MATTER: CASE STUDY RESULTS FOR PM 2.5 IN PHILADELPHIA, PA

    EPA Science Inventory

    A population exposure model for particulate matter (PM), called the Stochastic Human Exposure and Dose Simulation (SHEDS-PM) model, has been developed and applied in a case study of daily PM2.5 exposures for the population living in Philadelphia, PA. SHEDS-PM is a probabilisti...

  3. Adult Learning and Technology in OECD Countries. Proceedings of a Round Table (Philadelphia, Pennsylvania, February 14-16, 1996).

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France). Centre for Educational Research and Innovation.

    This book, which is based on the papers presented by the various countries attending an international conference on technology and adult learning, contains 16 papers examining the use of technology in adult learning programs in the context of major institutional and economic change. The following papers are included: "A View from Philadelphia:…

  4. Designing Interactive Courseware: Creating an Electronic Edition of the Notes of Debates in the Philadelphia Convention of 1787.

    ERIC Educational Resources Information Center

    Schick, James B. M.

    2002-01-01

    Describes the educational philosophy and decisions that shaped development of an electronic reader's edition of James Madison's notes on the debates of the Philadelphia Convention of 1787. Discusses the role of hypermedia in history instruction. %Illustrates and explains the design of the resource. (PAL)

  5. Acquisition Policy Planning and Litigation: Language Planning in the Context of "Y.S. v. District of Philadelphia."

    ERIC Educational Resources Information Center

    Skilton, Ellen E.

    1992-01-01

    This paper discusses language policy and educational practice in the context of a class action law suit filed on behalf of Asian students in Philadelphia concerning their linguistic and academic needs. It addresses both macro and micro perspectives in its discussion of litigation policy, acquisition policy planning, and Asian Americans in the…

  6. Boosting Adolescent and Young Adult Literacy: An Examination of Literacy Teaching and Learning in Philadelphia's Accelerated High Schools

    ERIC Educational Resources Information Center

    Gold, Eva; Edmunds, Kimberly; Maluk, Holly; Reumann-Moore, Rebecca

    2011-01-01

    In 2010-11, the School District of Philadelphia (the District) operated thirteen accelerated high schools that served approximately 2,000 under-credited, over-age students. Each of the accelerated schools was managed by one of seven external providers, each with its own educational approach, and each with a contractual agreement with the…

  7. Surface geophysics and porewater evaluation at the Lower Darby Creek Area Superfund Site, Philadelphia, Pennsylvania, 2013

    USGS Publications Warehouse

    Walker, Charles W.; Degnan, James R.; Brayton, Michael J.; Cruz, Roberto M.; Lorah, Michelle M.

    2015-01-01

    In cooperation with the U.S. Environmental Protection Agency (EPA), Region 3, the U.S. Geological Survey (USGS) is participating in an ongoing study to aid in the identification of subsurface heterogeneities that may act as preferential pathways for contaminant transport in and around the Lower Darby Creek Area (LDCA) Superfund Site, Philadelphia Pa. Lower Darby Creek, which flows into the Delaware River, borders the western part of the former landfill site. In 2013, the USGS conducted surface geophysics measurements and stream porewater sampling to provide additional data for EPA’s site characterization. This report contains data collected from field measurements of direct current (DC) resistivity, frequency-domain electromagnetic (FDEM) surveys, and stream porewater specific conductance (SC).

  8. The assessment of present-moment awareness and acceptance: the Philadelphia Mindfulness Scale.

    PubMed

    Cardaciotto, Leeann; Herbert, James D; Forman, Evan M; Moitra, Ethan; Farrow, Victoria

    2008-06-01

    The purpose of this project was to develop a bidimensional measure of mindfulness to assess its two key components: present-moment awareness and acceptance. The development and psychometric validation of the Philadelphia Mindfulness Scale is described, and data are reported from expert raters, two nonclinical samples (n = 204 and 559), and three clinical samples including mixed psychiatric outpatients (n = 52), eating disorder inpatients (n = 30), and student counseling center outpatients (n = 78). Exploratory and confirmatory factor analyses support a two-factor solution, corresponding to the two constituent components of the construct. Good internal consistency was demonstrated, and relationships with other constructs were largely as expected. As predicted, significant differences were found between the nonclinical and clinical samples in levels of awareness and acceptance. The awareness and acceptance subscales were not correlated, suggesting that these two constructs can be examined independently. Potential theoretical and applied uses of the measure are discussed.

  9. The Philadelphia (Ph) chromosome in leukemia. III. Complex Ph translocation plus inversion in chronic myelocytic leukemia.

    PubMed

    Morgan, R; Stebbins, R D; Hecht, F; Sandberg, A A

    1985-01-01

    Remarkable chromosome abnormalities were observed in bone marrow cells from a woman with chronic myelocytic leukemia and atypical tuberculosis due to Mycobacterium avium-intracellulare infection. Four chromosome breaks occurred at bands 1p13, 1q32, 11p15, and 22q11. These breaks resulted in a complex Philadelphia (Ph) translocation between chromosomes #1, #11, and #22 and in an inversion of chromosome #1. Oncogenes on these chromosomes include N-ras and c-sk on chromosome #1, c-H-ras on chromosome #11, and c-sis on chromosome #22. Complex chromosome rearrangements may facilitate multiple oncogene changes, thereby permitting several steps in cancer development to occur simultaneously.

  10. Incidental detection of congenital Robertsonian translocation at diagnosis of Philadelphia chromosome-positive acute lymphocytic leukemia.

    PubMed

    Yamaguchi, Tsukasa; Igarashi, Aiko; Kawamura, Machiko; Ozasa, Yuka; Yoshida, Masayuki; Kakihana, Kazuhiko; Sakamaki, Hisashi; Ohashi, Kazuteru

    2015-05-01

    A man in his early forties who had undergone 3 years of unsuccessful treatment for infertility due to oligospermia and asthenospermia developed fever and bone pain in December 20XX. He was subsequently diagnosed with acute lymphocytic leukemia. Conventional cytogenetic analysis revealed Robertsonian translocation (RT) with der(13;14)(q10;q10) in addition to the Philadelphia (Ph) chromosome. Dasatinib and prednisolone induced complete remission (CR) with disappearance of the Ph chromosome. However, RT persisted despite achieving CR. We speculate that RT is possibly congenital in our present case and might also have been responsible for the aforementioned infertility. Hematologists should be aware of the possibility that congenital chromosomal disorders might be found incidentally through diagnostic chromosome analysis for leukemia.

  11. Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest

    PubMed Central

    Mondet, Julie; Hussein, Kais; Mossuz, Pascal

    2015-01-01

    Cytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph− MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed. PMID:26525644

  12. Weight Status and Weight-Management Behaviors Among Philadelphia High School Students, 2007–2011

    PubMed Central

    Lenhart, Clare M.; Bauer, Katherine W.

    2013-01-01

    Introduction The prevalence of obesity among youth may be stabilizing and even declining in some areas of the United States. The objective of our study was to examine whether the stabilization in obesity prevalence among Philadelphia high school students was accompanied by changes in weight-management behaviors. Methods We evaluated changes in self-reported weight status and weight-management behaviors by using data collected by the Youth Risk Behavior Survey in 2007, 2009, and 2011. We used multivariable regression models controlling for race/ethnicity and age to estimate prevalence. Results Although the proportion of overweight and obese students did not change significantly during the study period, we found that approximately half of female students and 30% of male students reported trying to lose weight. Among female students, we observed significant increases in the proportion engaging in 5 or more days of physical activity per week (26.0% in 2007 to 31.9% in 2011; P = .003) and significant decreases in the proportion consuming at least 1 soda per day (31.1% in 2007 to 22.5% in 2011, P = .001). The proportion of female students who fasted for weight loss also increased significantly during the study period (12.2% in 2007 to 17.0% in 2011, P = .02). We found no significant changes in behavior among male students. Conclusion Although the prevalence of obesity and overweight may have reached a plateau among Philadelphia high school students, most students still failed to meet recommendations for healthful weight-management behaviors. Continued public health initiatives are necessary to promote participation in healthful weight-management behaviors. PMID:24070036

  13. Familial translocation involving chromosomes 1 and 9 in a patient with Philadelphia-positive CML

    SciTech Connect

    Rehman, K.; Rosner, F.; Shanske, A.

    1994-09-01

    CML has provided a model for understanding the genetic basis of neoplasia. Approximately 5% of Philadelphia-positive patients have a variant chromosome rearrangement. We recently evaluated a patient with a previously unreported simple variant translocation that is part of a familial rearrangement. He had a constitutional translocation, t(1;9)(p21;p22), which was initially identified after his wife had a routine amniocentesis. Case report: K.H. was a 54-year-old male with CML for 4 years. He had been treated until recently with hydroxyurea. An abnormal male karyotype, 46,XY,t(1;9)(q21;p22),t(9;22)(q34;q11) was recorded from an unstimulated blood sample soon after diagnosis. Both translocations involved the same number 9 homologue resulting in a derivative 9(1pter{r_arrow}1q21::9p22{r_arrow}9q34::22q11{r_arrow}22qter). A recent CT scan of the chest showed a lytic lesion of a rib with associated soft tissue mass in the right costo-vertebral angle. He was hospitalized for progressive pain in the right lower chest and fever, treated for a UTI, required multiple transfusions for declining hemoglobin and platelets and died shortly thereafter. Autopsy revealed widespread chloromas as part of terminal CML. At least 13 complex rearrangements involving chromosomes 1, 9 and 22 are known. Our case represents a unique rearrangement with a familial component and also unique breakpoints for a Philadelphia variant. In line with the current view of cancer as a clonal disorder, perhaps the constitutional translocation contributed to the multi-step nature of the malignant transformation. In fact, a number of cancer-specific breakpoints in both regions of 1p and 9p are involved in the familial translocation.

  14. C2 Body Fracture: Report of Cases Managed Conservatively by Philadelphia Collar

    PubMed Central

    Sadeghian, Homa

    2016-01-01

    Study Design Case series. Purpose To present results of conservative management in patients with pure C2 body fractures. Overview of Literature Axis body fractures, a less common subgroup of C2 fractures, are commonly classified as vertical coronal, vertical sagittal, and transverse subtypes. While the treatment paradigm for other C2 fractures is clear, there is insufficient evidence to support treatment guidelines for C2 body fractures. Methods Eleven patients with pure C2 body fractures were managed with external immobilization and followed thereafter. Results All neurologic examinations were normal. In computed tomography (CT) scans, four, two, three, and two patients had a coronal, sagittal, horizontal, and burst fracture, respectively. Magnetic resonance imaging showed hematoma and partial rupture in the anterior longitudinal ligament in four patients, posterior ligamentous complex injury in one, and normal ligamentous structure in six. All fractures were managed conservatively using the Philadelphia collar, which was continued until complete disappearance of symptoms (within 1–3 months in all patients). The decision to discontinue the neck collar was made by a dynamic neck X-ray and CT scan that showed complete bony fusion. All patients were then followed for an additional 1.5 years (mean follow-up of 21 months for all patients). No patient showed any neurologic symptoms or deficits during the follow-up period. Conclusions In patients with pure C2 body fracture, non-operative management with Philadelphia neck collar is a safe and efficacious option, even in the presence of some sort of ligamentous injury. PMID:27790321

  15. Simulation of ground-water flow in the Potomac-Raritan-Magothy aquifer system near the Defense Supply Center Philadelphia, and the Point Breeze Refinery, southern Philadelphia County, Pennsylvania

    USGS Publications Warehouse

    Schreffler, C.L.

    2001-01-01

    Ground-water flow in the Potomac-Raritan- Magothy aquifer system (PRM) in south Philadelphia and adjacent southwestern New Jersey was simulated by use of a three-dimensional, seven-layer finite-difference numerical flow model. The simulation was run from 1900, which was prior to groundwater development, through 1995 with 21 stress periods. The focus of the modeling was on a smaller area of concern in south Philadelphia in the vicinity of the Defense Supply Center Philadelphia (DSCP) and the Point Breeze Refinery (PBR). In order to adequately simulate the ground-water flow system in the area of concern, a much larger area was modeled that included parts of New Jersey where significant ground-water withdrawals, which affect water levels in southern Philadelphia, had occurred in the past. At issue in the area of concern is a hydrocarbon plume of unknown origin and time of release. The ground-water-flow system was simulated to estimate past water-level altitudes in and near the area of concern and to determine the effect of the Packer Avenue sewer, which lies south of the DSCP, on the ground-water-flow system. Simulated waterlevel altitudes for the lower sand unit of the PRM on the DSCP prior to 1945 ranged from pre-development, unstressed altitudes to 3 feet below sea level. Simulated water-level altitudes for the lower sand unit ranged from 3 to 7 feet below sea level from 1946 to 1954, from 6 to 10 feet below sea level from 1955 to 1968, and from 9 to 11 feet below sea level from 1969 to 1978. The lowest simulated water-level altitude on the DSCP was 10.69 feet below sea level near the end of 1974. Model simulations indicate ground water was infiltrating the Packer Avenue sewer prior to approximately 1947 or 1948. Subsequent to that time, simulated ground-water-level altitudes were lower than the bottom of the sewer.

  16. Urban sustainable energy development: A case study of the city of Philadelphia

    NASA Astrophysics Data System (ADS)

    Argyriou, Iraklis

    This study explores the role of cities in sustainable energy development through a governance-informed analysis. Despite the leading position of municipalities in energy sustainability, cities have been mostly conceptualized as sites where energy development is shaped by external policy scales, i.e. the national level. A growing body of research, however, critiques this analytical perspective, and seeks to better understand the type of factors and dynamics that influence energy sustainability within a multi-level policy context for urban energy. Given that particular circumstances are applicable across cities, a context-specific analysis can provide insight regarding how sustainable energy development takes place in urban areas. In applying such an analytical perspective on urban energy sustainability, this study undertakes a qualitative case study analysis for the city of Philadelphia, Pennsylvania, by looking at four key local policy initiatives relevant to building energy efficiency and solar electricity development at the municipal government and city-wide level. The evaluation of the initiatives suggests that renewable electricity use has increased substantially in the city over the last years but the installed capacity of local renewable electricity systems, including solar photovoltaics, is low. On the other hand, although the city has made little progress in meeting its building energy efficiency targets, more comprehensive action is taken in this area. The study finds that the above outcomes have been shaped mainly by four factors. The first is the city government's incremental policy approach aiming to develop a facilitative context for local action. The second is the role that a diverse set of stakeholders have in local sustainable energy development. The third is the constraints that systemic policy barriers create for solar power development. The fourth is the ways through which the relevant multi-level policy environment structures the city

  17. Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia

    ClinicalTrials.gov

    2015-10-29

    B-cell Adult Acute Lymphoblastic Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia

  18. Superfund record of decision (EPA Region 3): Publicker Industries, Inc., operable unit 3, Philadelphia, PA, December 28, 1995

    SciTech Connect

    1997-04-01

    This decision document presents the selected remedial action for Operable Unit No. 3 of the Publicker Industries Site (the Site) in Philadelphia, Pennsyvlania. The major components of the selected remedy include: Abandonment of on-Site ground water wells; Removal, treatment, and off-Site disposal of liquids and sediments in contaminated electric utilities; Removal, treatment and off-Site disposal of liquids and sediments in contaminated stormwater trenches and utilities; and Removal treatment and off-Site disposal of miscellaneous wastes.

  19. Health and housing collaboration at LAST: the Philadelphia Lead Abatement Strike Team.

    PubMed Central

    Campbell, Carla; Himmelsbach, Robert; Palermo, Peter; Tobin, Richard

    2005-01-01

    The Lead Abatement Strike Team (LAST) was developed in 2002 by the Philadelphia Department of Public Health (PDPH) in response to community concern about management of children with elevated blood lead levels (EBLLs). Fourteen hundred backlog properties (housing at least one child with EBLLs) were identified through inspection as having housing-based lead hazards for which no satisfactory environmental remediation (control of lead hazards) had been achieved. In the first two years of LAST, 834 new housing cases also were identified. The heightened awareness of this problem, sparked in part by community advocacy efforts, led to the appropriation of 1.5 million dollars for environmental remediation. A collaborative group of health, housing, and other officials was convened. Enforcement for remediation of properties with lead hazards was strengthened with the development of the Lead Court, a special judicial court devoted exclusively to hearing cases where owners had violated local lead poisoning prevention laws. Identifying a group of Pennsylvania-certified lead abatement contractors, expanding the health department's abatement team, creating temporary relocation capacity, and providing funding for basic housing system repair work were crucial to obtaining rapid remediation of homes. In the first two years of the LAST program, 1,037 properties (both backlog and new properties) that housed 1,476 children were remediated, representing a significant increase in remediation capacity. PMID:16134560

  20. ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells

    PubMed Central

    Karvela, Maria; Baquero, Pablo; Kuntz, Elodie M.; Mukhopadhyay, Arunima; Mitchell, Rebecca; Allan, Elaine K.; Chan, Edmond; Kranc, Kamil R.; Calabretta, Bruno; Salomoni, Paolo; Gottlieb, Eyal; Holyoake, Tessa L.; Helgason, G. Vignir

    2016-01-01

    ABSTRACT A major drawback of tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is that primitive CML cells are able to survive TKI-mediated BCR-ABL inhibition, leading to disease persistence in patients. Investigation of strategies aiming to inhibit alternative survival pathways in CML is therefore critical. We have previously shown that a nonspecific pharmacological inhibition of autophagy potentiates TKI-induced death in Philadelphia chromosome-positive cells. Here we provide further understanding of how specific and pharmacological autophagy inhibition affects nonmitochondrial and mitochondrial energy metabolism and reactive oxygen species (ROS)-mediated differentiation of CML cells and highlight ATG7 (a critical component of the LC3 conjugation system) as a potential specific therapeutic target. By combining extra- and intracellular steady state metabolite measurements by liquid chromatography-mass spectrometry with metabolic flux assays using labeled glucose and functional assays, we demonstrate that knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle. This leads to increased oxidative phosphorylation and mitochondrial ROS accumulation. Furthermore, following ROS accumulation, CML cells, including primary CML CD34+ progenitor cells, differentiate toward the erythroid lineage. Finally, ATG7 knockdown sensitizes CML progenitor cells to TKI-induced death, without affecting survival of normal cells, suggesting that specific inhibitors of ATG7 in combination with TKI would provide a novel therapeutic approach for CML patients exhibiting persistent disease. PMID:27168493

  1. 56th and Walnut: A Philly Gut Rehab Development; Philadelphia, Pennsylvania (Fact Sheet)

    SciTech Connect

    Not Available

    2013-11-01

    Load-bearing brick-masonry multifamily buildings are prevalent in urban areas across much of the Northeast and mid-Atlantic. In most instances, these buildings are un-insulated unless they have been renovated within the past two decades. Affordable housing capital budgets typically limit what can be spent and energy improvements often take a back seat to basic capital improvements such as interior finish upgrades and basic repairs. The Consortium for Advanced Residential Buildings (CARB) is researching cost effective solution packages for significant energy efficiency and indoor air-quality improvements in these urban buildings. To explore how these low-cost retrofits can effectively integrate energy efficiency upgrades, CARB partnered with Columbus Property Management and Development, Inc. on a community-scale gut rehabilitation project located at 56th Street and Walnut Street in Philadelphia, consisting of 32 units in eleven 3-story buildings. These buildings were built in the early 1900s using stone foundations and solid brick-masonry walls. They were renovated in the 1990s to have interior light gauge metal framing with R-13 batt in the above-grade walls, induced-draft furnaces, and central air conditioning.

  2. Clinical features of patients with Philadelphia-negative myeloproliferative neoplasms complicated by portal hypertension

    PubMed Central

    Yan, Matthew; Geyer, Holly; Mesa, Ruben; Atallah, Ehab; Callum, Jeannie; Bartoszko, Justyna; Yee, Karen; Maganti, Manjula; Wong, Florence; Gupta, Vikas

    2015-01-01

    Backgroud Portal hypertension (PHTN) has been reported to afflict 7-18% of patients with Philadelphia-negative myeloproliferative neoplasms (MPNs), with complications of variceal bleeding and ascites. The clinical features and outcomes of these patients are unclear. Patients and Methods In this multi-centre retrospective study, we evaluated the clinical features of 51 patients with MPNs complicated by PHTN. Results The diagnosis of underlying MPN was most frequently polycythemia vera (PV) (39%) and primary myelofibrosis (MF) (35%), followed by post-PV myelofibrosis (18%), essential thrombocythemia (ET) (4%) and post-ET myelofibrosis (4%). Frequency of JAK2 V617F mutation appears as expected in the underlying MPN. Thrombosis within the splanchnic circulation was prevalent in patients with polycythemia compared to other MPNs (76% vs. 26%, p=0.0007). Conclusions PV and MF patients have a higher incidence of PHTN in our population, with thrombosis contributing to PHTN development in PV patients. Patients with splanchnic circulation thrombosis are potential candidates for screening for portal hypertension. These data may be useful for developing screening strategies for early detection of PHTN in patients with MPN. PMID:25027569

  3. Correlates of blood pressure control behaviors among Korean Americans in the greater Philadelphia area.

    PubMed

    Lewis, Jay; Ma, Grace; Patterson, Freda; Wang, Min Qi

    2013-12-01

    This cross-sectional study was designed to identify correlates of blood pressure control behaviors, including participation in physical activity, maintaining a healthy diet, limiting alcohol and tobacco use, discussing blood pressure with a doctor, and getting screened for blood pressure. The study sample included 116 Korean American men and women aged 42 to 77 years (M = 58.7) who resided in the greater Philadelphia area. Intention to exercise, comfort exercising in the neighborhood, and confidence in the ability to find time to exercise were positively correlated with participating in physical activity. Knowledge about the benefits of a healthy diet and confidence in the ability to maintain a healthy diet were positively correlated with maintaining a healthy diet. Intention to visit a doctor, having a regular doctor, satisfaction with the doctor, having confidence in the doctor, and confidence in the ability to ask doctors about health issues were positively correlated with medical adherence (including adhering to medication regimen and seeing a doctor regularly).

  4. Creating a business environment in inventory management - The Philadelphia Electric Company experiences

    SciTech Connect

    Franks, A.J.; Birch, H. )

    1992-01-01

    Philadelphia Electric Company's (PECo's) Nuclear Engineering and Services Department was asked to develop a (non-fuel) inventory management philosophy that will optimize inventory dollars at Peach Bottom atomic power station and Limerick generating station. The ultimate goal of the project is to maximize the potential for the correct parts being available at the lowest possible level of investment. There are many factors that make the management of maintenance, repair, and operating (MRO) supply inventories more complicated than managing finished goods, work-in-progress, or raw materials. Determining correct inventory levels for nuclear power plants is complicated by the irregular demand for spare parts and the cyclic nature of demand caused by refueling outages. Based on the information collected, it was determined that PECo's nuclear group needed to develop policies and strategies to address the following issues: (1) inventory classification based on part criticality, usage, and demand forecast; (2) item level ordering policies based on classification system; (3) inventory performance management; and (4) management of obsolete/surplus parts. Currently, policies are being developed to manage surplus and obsolete materials. Opportunities are being explored regarding the potential capitalization of critical components and parts. The policies established for classification, ordering policies, and performance management are being translated into work processes via common procedures and guidelines.

  5. ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells.

    PubMed

    Karvela, Maria; Baquero, Pablo; Kuntz, Elodie M; Mukhopadhyay, Arunima; Mitchell, Rebecca; Allan, Elaine K; Chan, Edmond; Kranc, Kamil R; Calabretta, Bruno; Salomoni, Paolo; Gottlieb, Eyal; Holyoake, Tessa L; Helgason, G Vignir

    2016-06-01

    A major drawback of tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is that primitive CML cells are able to survive TKI-mediated BCR-ABL inhibition, leading to disease persistence in patients. Investigation of strategies aiming to inhibit alternative survival pathways in CML is therefore critical. We have previously shown that a nonspecific pharmacological inhibition of autophagy potentiates TKI-induced death in Philadelphia chromosome-positive cells. Here we provide further understanding of how specific and pharmacological autophagy inhibition affects nonmitochondrial and mitochondrial energy metabolism and reactive oxygen species (ROS)-mediated differentiation of CML cells and highlight ATG7 (a critical component of the LC3 conjugation system) as a potential specific therapeutic target. By combining extra- and intracellular steady state metabolite measurements by liquid chromatography-mass spectrometry with metabolic flux assays using labeled glucose and functional assays, we demonstrate that knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle. This leads to increased oxidative phosphorylation and mitochondrial ROS accumulation. Furthermore, following ROS accumulation, CML cells, including primary CML CD34(+) progenitor cells, differentiate toward the erythroid lineage. Finally, ATG7 knockdown sensitizes CML progenitor cells to TKI-induced death, without affecting survival of normal cells, suggesting that specific inhibitors of ATG7 in combination with TKI would provide a novel therapeutic approach for CML patients exhibiting persistent disease. PMID:27168493

  6. Blinatumomab for the Treatment of Philadelphia Chromosome-Negative, Precursor B-cell Acute Lymphoblastic Leukemia.

    PubMed

    Wolach, Ofir; Stone, Richard M

    2015-10-01

    Blinatumomab is a CD19/CD3 bispescific antibody designed to redirect T cells toward malignant B cells and induce their lysis. It recently gained accelerated approval by the FDA for the treatment of relapsed or refractory Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (RR-ALL). In the phase II trial that served as the basis for approval, blinatumomab demonstrated significant single-agent activity and induced remission [complete remission (CR) and CR with incomplete recovery of peripheral blood counts (CRh)] in 43% of 189 adult patients with RR-ALL; the majority of responders (82%) also attained negative minimal residual disease (MRD(-)) status that did not generally translate into long-term remissions in most cases. Additional studies show that blinatumomab can induce high response rates associated with lasting remissions in patients in first remission treated for MRD positivity, suggesting a role for blinatumomab in the upfront, MRD-positive setting. Blinatumomab infusion follows a predictable immunopharmacologic profile, including early cytokine release that can be associated with a clinical syndrome, T-cell expansion, and B-cell depletion. Neurologic toxicities represent a unique toxicity that shares similarities with adverse effects of other T-cell engaging therapies. Further studies are needed to clarify the optimal disease setting and timing for blinatumomab therapy. Additional insights into the pathogenesis, risk factors, and prevention of neurologic toxicities as well as a better understanding of the clinical consequences and biologic pathways that are associated with drug resistance are needed. PMID:26283683

  7. Salivary gland neoplasms in children: a 10-year survey at the Children's Hospital of Philadelphia.

    PubMed

    Kessler, A; Handler, S D

    1994-06-01

    Fifteen salivary gland tumors were treated at The Children's Hospital of Philadelphia between 1982 and 1991. Eight of these lesions were malignant and 7 were benign. All of the benign tumors were pleomorphic adenomas. For these, superficial parotidectomy or excision of the submandibular gland was the treatment of choice. One child had recurrence 2 years after her initial surgery. Among the malignant lesions, mucoepidermoid carcinoma was diagnosed in 5 children, and acinic cell carcinoma in 3. Six malignant tumors involved the parotid gland, while 2 originated in the submandibular salivary gland. Superficial or total parotidectomy, or excision of the submandibular gland was performed, according to the nature and the location of the lesion. The facial nerve was sacrificed in one patient because of extensive involvement of the nerve. A 2-year survival rate of 100% was achieved, and all the patients were free of disease at the end of the follow-up period. Successful management of salivary gland lesions in children requires a high index of suspicion of possible malignancy and complete surgical removal as the initial treatment. Radiation therapy is recommended in the management of those patients with microscopic residual tumor and/or nodal involvement.

  8. Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia.

    PubMed

    Leonard, Jessica T; Rowley, Joelle S J; Eide, Christopher A; Traer, Elie; Hayes-Lattin, Brandon; Loriaux, Marc; Spurgeon, Stephen E; Druker, Brian J; Tyner, Jeffrey W; Chang, Bill H

    2016-08-31

    Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+)ALL) remains a challenge. Although the addition of targeted tyrosine kinase inhibitors (TKIs) to standard cytotoxic therapy has greatly improved upfront treatment, treatment-related morbidity and mortality remain high. TKI monotherapy provides only temporary responses and renders patients susceptible to the development of TKI resistance. Thus, identifying agents that could enhance the activity of TKIs is urgently needed. Recently, a selective inhibitor of B cell lymphoma 2 (BCL-2), ABT-199 (venetoclax), has shown impressive activity against hematologic malignancies. We demonstrate that the combination of TKIs with venetoclax is highly synergistic in vitro, decreasing cell viability and inducing apoptosis in Ph(+)ALL. Furthermore, the multikinase inhibitors dasatinib and ponatinib appear to have the added advantage of inducing Lck/Yes novel tyrosine kinase (LYN)-mediated proapoptotic BCL-2-like protein 11 (BIM) expression and inhibiting up-regulation of antiapoptotic myeloid cell leukemia 1 (MCL-1), thereby potentially overcoming the development of venetoclax resistance. Evaluation of the dasatinib-venetoclax combination for the treatment of primary Ph(+)ALL patient samples in xenografted immunodeficient mice confirmed the tolerability of this drug combination and demonstrated its superior antileukemic efficacy compared to either agent alone. These data suggest that the combination of dasatinib and venetoclax has the potential to improve the treatment of Ph(+)ALL and should be further evaluated for patient care. PMID:27582059

  9. African American community leaders' policy recommendations for reducing racial disparities in HIV infection, treatment and care: results from a community-based participatory research project in Philadelphia, PA

    PubMed Central

    Nunn, Amy; Sanders, Julia; Carson, Lee; Thomas, Gladys; Cornwall, Alexandra; Towey, Caitlin; Lee, Hwajin; Tasco, Marian; Shabazz-El, Waheedah; Yolken, Annajane; Smith, Tyrone; Bell, Gary; Feller, Sophie; Smith, Erin; James, George; Dunston, Brenda Shelton; Green, Derek

    2015-01-01

    African Americans account for 45% of new HIV infections in the United States. Little empirical research investigates African American community leaders' normative recommendations for addressing these disparities. Philadelphia's HIV infection rate is five times the national average, nearly 70% of new infections are among African Americans, and 2% of African Americans in Philadelphia are living with HIV/AIDS. Using a community-based participatory research (CBPR) approach, we convened focus groups among 52 African American community leaders from diverse backgrounds to solicit normative recommendations for reducing Philadelphia's racial disparities in HIV infection. Leaders recommended: 1) Philadelphia's city government should raise awareness about HIV/AIDS with media campaigns featuring local leaders; 2) Local HIV prevention interventions should address social and structural factors influencing HIV risks rather than focus exclusively on mode of HIV transmission; 3) Resources should be distributed to the most heavily impacted neighborhoods of Philadelphia; and 4) Faith institutions should play a critical role in HIV testing, treatment and prevention efforts. We developed a policy memo highlighting these normative recommendations for how to enhance local HIV prevention policy. This policy memo led to Philadelphia City Council hearings about HIV/AIDS in October 2010 and subsequently informed local HIV/AIDS prevention policy and development of local HIV prevention interventions. This CBPR case study offers important lessons for effectively engaging community leaders in research to promote HIV/AIDS policy change. PMID:24879446

  10. Philadelphia-Negative Classical Myeloproliferative Neoplasms: Critical Concepts and Management Recommendations From European LeukemiaNet

    PubMed Central

    Barbui, Tiziano; Barosi, Giovanni; Birgegard, Gunnar; Cervantes, Francisco; Finazzi, Guido; Griesshammer, Martin; Harrison, Claire; Hasselbalch, Hans Carl; Hehlmann, Rudiger; Hoffman, Ronald; Kiladjian, Jean-Jacques; Kröger, Nicolaus; Mesa, Ruben; McMullin, Mary F.; Pardanani, Animesh; Passamonti, Francesco; Vannucchi, Alessandro M.; Reiter, Andreas; Silver, Richard T.; Verstovsek, Srdan; Tefferi, Ayalew

    2011-01-01

    We present a review of critical concepts and produce recommendations on the management of Philadelphia-negative classical myeloproliferative neoplasms, including monitoring, response definition, first- and second-line therapy, and therapy for special issues. Key questions were selected according the criterion of clinical relevance. Statements were produced using a Delphi process, and two consensus conferences involving a panel of 21 experts appointed by the European LeukemiaNet (ELN) were convened. Patients with polycythemia vera (PV) and essential thrombocythemia (ET) should be defined as high risk if age is greater than 60 years or there is a history of previous thrombosis. Risk stratification in primary myelofibrosis (PMF) should start with the International Prognostic Scoring System (IPSS) for newly diagnosed patients and dynamic IPSS for patients being seen during their disease course, with the addition of cytogenetics evaluation and transfusion status. High-risk patients with PV should be managed with phlebotomy, low-dose aspirin, and cytoreduction, with either hydroxyurea or interferon at any age. High-risk patients with ET should be managed with cytoreduction, using hydroxyurea at any age. Monitoring response in PV and ET should use the ELN clinicohematologic criteria. Corticosteroids, androgens, erythropoiesis-stimulating agents, and immunomodulators are recommended to treat anemia of PMF, whereas hydroxyurea is the first-line treatment of PMF-associated splenomegaly. Indications for splenectomy include symptomatic portal hypertension, drug-refractory painful splenomegaly, and frequent RBC transfusions. The risk of allogeneic stem-cell transplantation–related complications is justified in transplantation-eligible patients whose median survival time is expected to be less than 5 years. PMID:21205761

  11. Black carbon concentrations in a goods-movement neighborhood of Philadelphia, PA

    PubMed Central

    Mizes, Chris; Lee, John; Burstyn, Igor

    2014-01-01

    Communities along the Delaware River in Philadelphia, USA such as Port Richmond, are subject to traffic associated with goods movement to and from port facilities and local industry. Air pollution associated with this traffic poses an environmental health concern in this and other urban areas. Our study measures black carbon (BC) in Port Richmond and examines its relationship to expected sources such as truck traffic. We used a participatory sampling method to conduct 1-min measurements over 8-hour periods at 14 homes, a school and park, during a 4-week period in June 2012. Measurements over 9 sampling days had a 30-min average BC concentration of 1.2 μg m−3, and a maximum of 12 μg m−3. Statistical analyses showed some effect of traffic, but greater association between BC concentrations and weather and time of day. BC concentrations varied more by location than by day, and distance to traffic arterials and interstate freeway was a predictor of this variance. While our dataset is limited by number and variety of observations, major findings indicate that BC concentration varies more by location than by day, there is a decrease in median BC concentration with increased distance from an interstate highway, and an expected effect of diesel traffic on average daily BC concentrations. Our findings are an important step towards understanding patterns and determinants of BC concentration in communities colocated with major ports. Our study also demonstrates that participatory methods in air pollution monitoring can help increase awareness of local air pollution levels. PMID:24668123

  12. Black carbon concentrations in a goods-movement neighborhood of Philadelphia, PA.

    PubMed

    Kondo, Michelle C; Mizes, Chris; Lee, John; Burstyn, Igor

    2014-07-01

    Communities along the Delaware River in Philadelphia, USA such as Port Richmond, are subject to traffic associated with goods movement to and from port facilities and local industry. Air pollution associated with this traffic poses an environmental health concern in this and other urban areas. Our study measures black carbon (BC) in Port Richmond and examines its relationship to expected sources such as truck traffic. We used a participatory sampling method to conduct 1-min measurements over 8-hour periods at 14 homes, a school and park, during a 4-week period in June 2012. Measurements over 9 sampling days had a 30-min average BC concentration of 1.2 μg m(-3), and a maximum of 12 μg m(-3). Statistical analyses showed some effect of traffic, but greater association between BC concentrations and weather and time of day. BC concentrations varied more by location than by day, and distance to traffic arterials and interstate freeway was a predictor of this variance. While our dataset is limited by number and variety of observations, major findings indicate that BC concentration varies more by location than by day, there is a decrease in median BC concentration with increased distance from an interstate highway, and an expected effect of diesel traffic on average daily BC concentrations. Our findings are an important step towards understanding patterns and determinants of BC concentration in communities colocated with major ports. Our study also demonstrates that participatory methods in air pollution monitoring can help increase awareness of local air pollution levels.

  13. Social, Structural and Behavioral Drivers of Concurrent Partnerships among African American Men in Philadelphia

    PubMed Central

    Nunn, Amy; Dickman, Samuel; Cornwall, Alexandra; Rosengard, Cynthia; Kwakwa, Helena; Kim, Daniel; James, George; Mayer, Kenneth H.

    2011-01-01

    African Americans face disproportionately higher risks of HIV infection. Concurrent sexual relationships, or sexual partnerships that overlap in time, are more common among African Americans than individuals of other races and may contribute to racial disparities in HIV infection. However, little is known about attitudes, norms and practices among individuals engaged in concurrent partnerships. Little is also known about the processes through which structural, behavioral and social factors influence concurrent sexual relationships. We recruited 24 heterosexual African American men involved in concurrent sexual relationships from a public health clinic in Philadelphia. We conducted in-depth interviews exploring these men's sexual practices; social norms and individual attitudes about concurrency; perceived sexual health risks with main and non-main partners; and the social, structural and behavioral factors contributing to concurrent sexual relationships. Twenty-two men reported having one main and one or more non-main partners; two reported having no main partners. Respondents generally perceived sexual relationships with non-main partners as riskier than relationships with main partners and used condoms far less frequently with main than non-main partners. Most participants commented that it is acceptable and often expected for men and women to engage in concurrent sexual relationships. Social factors influencing participants’ concurrent partnerships included being unmarried and trusting neither main nor non-main partners. Structural factors influencing concurrent partnerships included economic dependence on one or more women, incarceration, unstable housing, and unemployment. Several men commented that individual behavioral factors such as alcohol and cocaine use contributed to their concurrent sexual partnerships. Future research and interventions related to sexual concurrency should address social and structural factors in addition to conventional HIV risk

  14. Concentration of Tobacco Advertisements at SNAP and WIC Stores, Philadelphia, Pennsylvania, 2012

    PubMed Central

    Chilton, Mariana; Zhao, Qian-Wei; Szymkowiak, Dorota; Coffman, Ryan; Mallya, Giridhar

    2015-01-01

    Introduction Tobacco advertising is widespread in urban areas with racial/ethnic minority and low-income households that participate in nutrition assistance programs. Tobacco sales and advertising are linked to smoking behavior, which may complicate matters for low-income families struggling with disparate health risks relating to nutrition and chronic disease. We investigated the relationship between the amount and type of tobacco advertisements on tobacco outlets and the outlet type and location. Methods By using field visits and online images, we inspected all licensed tobacco retail outlets in Philadelphia (N = 4,639). Point pattern analyses were used to identify significant clustering of tobacco outlets and outlets with exterior tobacco advertisements. Logistic regression was used to analyze the relationship between the outlet’s acceptance of Supplemental Nutrition Assistance Program (SNAP) and Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and the presence of tobacco advertisements. Results Tobacco outlets with exterior tobacco advertisements were significantly clustered in several high-poverty areas. Controlling for racial/ethnic and income composition and land use, SNAP and WIC vendors were significantly more likely to have exterior (SNAP odds ratio [OR], 2.11; WIC OR, 1.59) and interior (SNAP OR, 3.43; WIC OR, 1.69) tobacco advertisements than other types of tobacco outlets. Conclusion Tobacco advertising is widespread at retail outlets, particularly in low-income and racial/ethnic minority neighborhoods. Policy makers may be able to mitigate the effects of this disparate exposure through tobacco retail licensing, local sign control rules, and SNAP and WIC authorization. PMID:25654220

  15. Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia.

    PubMed

    Kim, Dae-Young; Joo, Young-Don; Lim, Sung-Nam; Kim, Sung-Doo; Lee, Jung-Hee; Lee, Je-Hwan; Kim, Dong Hwan Dennis; Kim, Kihyun; Jung, Chul Won; Kim, Inho; Yoon, Sung-Soo; Park, Seonyang; Ahn, Jae-Sook; Yang, Deok-Hwan; Lee, Je-Jung; Lee, Ho-Sup; Kim, Yang Soo; Mun, Yeung-Chul; Kim, Hawk; Park, Jae Hoo; Moon, Joon Ho; Sohn, Sang Kyun; Lee, Sang Min; Lee, Won Sik; Kim, Kyoung Ha; Won, Jong-Ho; Hyun, Myung Soo; Park, Jinny; Lee, Jae Hoon; Shin, Ho-Jin; Chung, Joo-Seop; Lee, Hyewon; Eom, Hyeon-Seok; Lee, Gyeong Won; Cho, Young-Uk; Jang, Seongsoo; Park, Chan-Jeoung; Chi, Hyun-Sook; Lee, Kyoo-Hyung

    2015-08-01

    We investigated the effects of nilotinib plus multiagent chemotherapy, followed by consolidation/maintenance or allogeneic hematopoietic cell transplantation (allo-HCT) for adult patients with newly diagnosed Philadelphia-positive (Ph-pos) acute lymphoblastic leukemia (ALL). Study subjects received induction treatment that comprised concurrent vincristine, daunorubicin, prednisolone, and nilotinib. After achieving complete hematologic remission (HCR), subjects received either 5 courses of consolidation, followed by 2-year maintenance with nilotinib, or allo-HCT. Minimal residual disease (MRD) was assessed at HCR, and every 3 months thereafter. The molecular responses (MRs) were defined as MR3 for BCR-ABL1/G6PDH ratios ≤10(-3) and MR5 for ratios <10(-5). Ninety evaluable subjects, ages 17 to 71 years, were enrolled in 17 centers. The HCR rate was 91%; 57 subjects received allo-HCT. The cumulative MR5 rate was 94%; the 2-year hematologic relapse-free survival (HRFS) rate was 72% for 82 subjects that achieved HCR, and the 2-year overall survival rate was 72%. Subjects that failed to achieve MR3 or MR5 were 9.1 times (P = .004) or 6.3 times (P = .001) more prone to hematologic relapse, respectively, than those that achieved MR3 or MR5. MRD statuses just before allo-HCT and at 3 months after allo-HCT were predictive of 2-year HRFS. Adverse events occurred mainly during induction, and most were reversible with dose reduction or transient interruption of nilotinib. The combination of nilotinib with high-dose cytotoxic drugs was feasible, and it effectively achieved high cumulative complete molecular remission and HRFS rates. The MRD status at early postremission time was predictive of the HRFS. This trial was registered at www.clinicaltrials.gov as #NCT00844298.

  16. Black carbon concentrations in a goods-movement neighborhood of Philadelphia, PA.

    PubMed

    Kondo, Michelle C; Mizes, Chris; Lee, John; Burstyn, Igor

    2014-07-01

    Communities along the Delaware River in Philadelphia, USA such as Port Richmond, are subject to traffic associated with goods movement to and from port facilities and local industry. Air pollution associated with this traffic poses an environmental health concern in this and other urban areas. Our study measures black carbon (BC) in Port Richmond and examines its relationship to expected sources such as truck traffic. We used a participatory sampling method to conduct 1-min measurements over 8-hour periods at 14 homes, a school and park, during a 4-week period in June 2012. Measurements over 9 sampling days had a 30-min average BC concentration of 1.2 μg m(-3), and a maximum of 12 μg m(-3). Statistical analyses showed some effect of traffic, but greater association between BC concentrations and weather and time of day. BC concentrations varied more by location than by day, and distance to traffic arterials and interstate freeway was a predictor of this variance. While our dataset is limited by number and variety of observations, major findings indicate that BC concentration varies more by location than by day, there is a decrease in median BC concentration with increased distance from an interstate highway, and an expected effect of diesel traffic on average daily BC concentrations. Our findings are an important step towards understanding patterns and determinants of BC concentration in communities colocated with major ports. Our study also demonstrates that participatory methods in air pollution monitoring can help increase awareness of local air pollution levels. PMID:24668123

  17. Motivations for prescription drug misuse among young men who have sex with men (YMSM) in Philadelphia

    PubMed Central

    Kecojevic, Aleksandar; Corliss, Heather L.; Lankenau, Stephen E.

    2015-01-01

    Background Prescription drug misuse (i.e. opioids, tranquilizers and stimulants) has become the fastest growing area of substance abuse among young adults. Limited studies focus on prescription drug misuse among young men who have sex with men (YMSM, aged 18–29 years). Furthermore, little is known about YMSM’s motivations for misuse. The purpose of this study was to explore personal motivations for prescription drug misuse among YMSM, including the possible connection between misuse and sexual behaviors. Methods As part of a larger mixed methods study of 191 YMSM recruited in Philadelphia during 2012–2013, we conducted semi-structured qualitative interviews with 25 of these participants to gather additional contextual information about their prescription drug misuse. We conducted thematic analysis of qualitative data. Results While our results corroborated previous literature on motives for misuse of prescription drugs, our data yielded some distinct motivations specific among YMSM. These motives included social/recreational motives, facilitating sex with other men (including motives such as use of opioids for less painful anal receptive sex), and psychological motives such as depression, stress management, coping with everyday hardships (opioids and tranquilizers) or feeling more energized (stimulants). Prescription drugs were commonly misused within the broader contexts of participants' polysubstance use, adding to the significance of this problem. Conclusions Our findings offer insights into YMSM’s motivations for prescription drug misuse, and point to the importance of recognizing and addressing them. While substance use is likely related to various psychosocial issues impacting YMSM, it also may lead to significant health consequences. Results support the need to include prescription drugs and polysubstance use in harm reduction messages and treatment approaches aimed at substance using YMSM. PMID:25936445

  18. Philadelphia Geriatric Morale Scale in Essential Tremor: A Population-Based Study in Three Spanish Communities

    PubMed Central

    Louis, Elan D.; Benito-León, Julián; Bermejo-Pareja, Félix

    2009-01-01

    BACKGROUND Essential tremor (ET) is associated with both functional disability and depression. Each could contribute to a poor sense of well-being and low morale. We hypothesized that morale would be lower in ET cases than controls. METHODS Using a population-based, cross-sectional design, morale was assessed in 187 ET cases and 561 matched controls living in three communities in central Spain using the Philadelphia Geriatric Center Morale Scale (PGCMS)(range = 0 [low morale]–17), which included three dimensions of psychological well-being: agitation, lonely dissatisfaction, and attitude toward own aging. RESULTS The PGCMS score was lower in ET cases than controls (9.41 ± 3.21 vs. 10.39 ± 2.92, p < 0.001), as were the Agitation subscore (3.17 ± 1.71 vs. 3.78 ± 1.67, p < 0.001) and Lonely Dissatisfaction subscore (3.75 ± 1.34 vs. 4.02 ± 1.24, p < 0.05). Nearly one-half of the ET cases were classified as having low morale compared with only one-third of controls (p = 0.006). In a linear regression analysis adjusting for demographic factors and multiple comorbid conditions, ET cases had a lower log PGCMS score than controls (p < 0.001). Exclusion of participants on antidepressant medication did not change the results. CONCLUSIONS Our results indicate that morale is significantly lower in community-dwelling ET cases than in matched controls. This lower morale could in part be a proxy for mild, untreated depression. It therefore seems important to detect and then possibly treat this problem to improve the psychological well-being of patients with this disease. PMID:18512746

  19. Current Concepts in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

    PubMed Central

    Bernt, Kathrin M.; Hunger, Stephen P.

    2014-01-01

    The t(9;22)(q34;q11) or Philadelphia chromosome creates a BCR–ABL1 fusion gene encoding for a chimeric BCR–ABL1 protein. It is present in 3–4% of pediatric acute lymphoblastic leukemia (Ph+ ALL), and about 25% of adult ALL cases. Prior to the advent of tyrosine kinase inhibitors (TKI), Ph+ ALL was associated with a very poor prognosis despite the use of intensive chemotherapy and frequently hematopoietic stem-cell transplantation (HSCT) in first remission. The development of TKIs revolutionized the therapy of Ph+ ALL. Addition of the first generation ABL1 class TKI imatinib to intensive chemotherapy dramatically increased the survival for children with Ph+ ALL and established that many patients can be cured without HSCT. In parallel, the mechanistic understanding of Ph+ ALL expanded exponentially through careful mapping of pathways downstream of BCR–ABL1, the discovery of mutations in master regulators of B-cell development such as IKZF1 (Ikaros), PAX5, and early B-cell factor (EBF), the recognition of the complex clonal architecture of Ph+ ALL, and the delineation of genomic, epigenetic, and signaling abnormalities contributing to relapse and resistance. Still, many important basic and clinical questions remain unanswered. Current clinical trials are testing second generation TKIs in patients with newly diagnosed Ph+ ALL. Neither the optimal duration of therapy nor the optimal chemotherapy backbone are currently defined. The role of HSCT in first remission and post-transplant TKI therapy also require further study. In addition, it will be crucial to continue to dig deeper into understanding Ph+ ALL at a mechanistic level, and translate findings into complementary targeted approaches. Expanding targeted therapies hold great promise to decrease toxicity and improve survival in this high-risk disease, which provides a paradigm for how targeted therapies can be incorporated into treatment of other high-risk leukemias. PMID:24724051

  20. Photokeratitis Linked to Metal Halide Bulbs in Two Gymnasiums - Philadelphia, Pennsylvania, 2011 and 2013.

    PubMed

    Finn, Lauren E; Gutowski, Jennifer; Alles, Steve; Mirowitz, Naomi; Johnson, Caroline; Osterhoudt, Kevin C; Patel, Ami

    2016-01-01

    In December 2011 and December 2013, the Philadelphia Department of Public Health (PDPH) received separate reports of clusters of photokeratitis linked to gymnasium events. Photokeratitis, a painful eye condition resulting from unprotected exposure to ultraviolet radiation, has previously been linked to metal halide lamps with broken outer envelopes (1,2). To investigate the cause of these clusters and further characterize patients with photokeratitis, PDPH administered questionnaires to potentially exposed persons, established a case definition, and conducted environmental assessments of both gymnasiums. Because event attendee registration information was available, a cohort study was conducted to evaluate the 2011 cluster of 242 persons who met the photokeratitis case definition. A case-series investigation was conducted to evaluate the 2013 cluster of 20 persons who met the photokeratitis case definition for that event. These investigations indicated that Type R metal halide bulbs with broken outer envelopes found in both gymnasiums were the probable cause of the photokeratitis. The Food and Drug Administration has made a number of recommendations regarding the use of metal halide bulbs in facilities where bulbs are at elevated risk for breaking, such as schools and indoor sports facilities (3). Because Type R metal halide lamps do not self-extinguish once the outer envelope is broken, these bulbs should be removed from settings with a high risk for outer envelope rupture, such as gymnasiums, or should be placed within enclosed fixtures. In instances where these bulbs cannot be exchanged for self-extinguishing lamps, Type R lamps with a broken outer envelope should be replaced immediately to limit exposure to ultraviolet radiation. A broken outer envelope can be detected by the presence of glass on the floor, or visual examination of the bulb when the power is turned off. A broken outer envelope is difficult to detect when the lamp is emitting light. PMID

  1. Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia.

    PubMed

    Zhang, Hailong; Gu, Lubing; Liu, Tao; Chiang, Kuang-Yueh; Zhou, Muxiang

    2014-01-01

    Nilotinib is a selective BCR-ABL tyrosine kinase inhibitor related to imatinib that is more potent than imatinib. Nilotinib is widely used to treat chronic myelogenous leukemia (CML) and Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL). The present study identifies Mouse double minute 2 homolog (MDM2) as a target of nilotinib. In studying ALL cell lines, we found that the expression of MDM2 in both Philadelphia positive (Ph+) and Philadelphia negative (Ph-) ALL cells was remarkably inhibited by nilotinib, in a dose- and time-dependent manner. Further studies demonstrated that nilotinib inhibited MDM2 at the post-translational level by inducing MDM2 self-ubiquitination and degradation. Nilotinib-mediated MDM2 downregulation did not result in accumulation and activation of p53. Inhibition of MDM2 in nilotinib-treated ALL cells led to downregulation of the anti-apoptotic protein X-linked inhibitor of apoptosis protein (XIAP), a translational target of MDM2, resulting in activation of caspases. Inhibition of XIAP following nilotinib-mediated downregulation of MDM2 resulted in apoptosis of MDM2-expressing ALL; however, similar nilotinib treatment induced stronger apoptosis in Ph+/MDM2+ ALL than in Ph-/MDM2+ or Ph+/MDM2- ALL. The ALL cells that were Ph-/MDM2- were totally resistant to nilotinib. These results suggested that nilotinib can inhibit MDM2 and induce a p53-independent apoptosis pathway by downregulating XIAP; thus, nilotinib can treat not only Ph+, but also Ph- ALL patients whose cancer cells overexpress MDM2.

  2. Otto Rank, the Rankian circle in Philadelphia, and the origins of Carl Rogers' person-centered psychotherapy.

    PubMed

    deCarvalho, R J

    1999-05-01

    Otto Rank's will therapy helped shape the ideas and techniques of relationship therapy developed by the Philadelphia social workers Jessie Taft, Virginia Robinson, and Frederick Allen in the 1930s. Rank's work and these ideas and techniques in turn strongly influenced the formulation of Carl Rogers' person-centered psychotherapy. This article compares and contrasts will, relationship, and person-centered approaches to psychotherapy and discusses the social factors--primarily the professional conflicts between a male-dominated psychiatry and female social workers over the independent practice of psychotherapy--that were crucial in the dissemination of Rank's psychological thought and the early popularity of Rogers.

  3. Is JAK2V617F Mutation the Only Factor for Thrombosis in Philadelphia-Negative Chronic Myeloproliferative Neoplasms?

    PubMed

    Uyanik, Mehmet Sevki; Baysal, Mehmet; Pamuk, Gulsum Emel; Maden, Muhammet; Akker, Mustafa; Umit, Elif Gulsum; Demir, Muzaffer; Aydogdu, Erkan

    2016-09-01

    The most common genetic disorder in Philadelphia negative chronic myeloproliferative neoplasms is the JAK2-V617F mutation. In the present study, we aimed to determine risk factors for thrombosis in patients with essential thrombocytosis and polycythemia vera. We screened the medical records of 101 patients. Risk factors which may predict thrombosis were recorded. Venous thrombosis (VT) before diagnosis was significantly higher in JAK2 positive patients. VT after diagnosis was similar in JAK2 positive and negative groups, and was significantly higher in elderly patients. Treatment places importance on the JAK2 mutation under unmodifiable cardiovascular risk factors such as advanced age after diagnosis. PMID:27429517

  4. The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth.

    PubMed

    Satterthwaite, Theodore D; Connolly, John J; Ruparel, Kosha; Calkins, Monica E; Jackson, Chad; Elliott, Mark A; Roalf, David R; Ryan Hopsona, Karthik Prabhakaran; Behr, Meckenzie; Qiu, Haijun; Mentch, Frank D; Chiavacci, Rosetta; Sleiman, Patrick M A; Gur, Ruben C; Hakonarson, Hakon; Gur, Raquel E

    2016-01-01

    The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale study of child development that combines neuroimaging, diverse clinical and cognitive phenotypes, and genomics. Data from this rich resource is now publicly available through the Database of Genotypes and Phenotypes (dbGaP). Here we focus on the data from the PNC that is available through dbGaP and describe how users can access this data, which is evolving to be a significant resource for the broader neuroscience community for studies of normal and abnormal neurodevelopment.

  5. Subdural Hematoma Associated with Dasatinib and Intrathecal Methotrexate Treatment in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia.

    PubMed

    Ureshino, Hiroshi; Nishioka, Atsujiro; Kojima, Kensuke; Kizuka, Haruna; Sano, Haruhiko; Shindo, Takero; Kubota, Yasushi; Ando, Toshihiko; Kimura, Shinya

    2016-01-01

    Dasatinib has been associated with an increased risk of bleeding, with the most prominent risk noted in patients with advanced-stage chronic myeloid leukemia and thrombocytopenia. We herein report two cases of Philadelphia chromosome-positive acute lymphoblastic leukemia in which a subdural hematoma developed in association with low-dose (40-50 mg/day) dasatinib treatment and lumbar puncture for intrathecal methotrexate injection. Both patients were in complete remission, with normal platelet counts and coagulation status. We suggest that dasatinib, even at a low dose, may impair platelet aggregation and that lumbar puncture may increase the risk of a subdural hematoma (occasionally bilateral) in patients receiving dasatinib. PMID:27629971

  6. Acute, fatal Sarcocystis calchasi-associated hepatitis in Roller pigeons (Columba livia f. dom.) at Philadelphia Zoo.

    PubMed

    Trupkiewicz, J G; Calero-Bernal, R; Verma, S K; Mowery, J; Davison, S; Habecker, P; Georoff, T A; Ialeggio, D M; Dubey, J P

    2016-01-30

    Four Roller pigeons (Columba livia f. dom.) at the Philadelphia Zoo died suddenly. Necropsy examination revealed macroscopic hepatitis. Microscopically, the predominant lesions were in liver, characterized with necrosis and mixed cell inflammatory response. Sarcocystis calchasi-like schizonts and free merozoites were identified in liver. Transmission electron microscopy confirmed that schizonts were in hepatocytes. A few schizonts were in spleen. PCR using S. calchasi-specific primers confirmed the diagnosis. Neither lesions nor protozoa were found in brain and muscles. This is the first report of acute visceral S. calchasi-associated sarcocystosis in naturally infected avian hosts.

  7. Otto Rank, the Rankian circle in Philadelphia, and the origins of Carl Rogers' person-centered psychotherapy.

    PubMed

    deCarvalho, R J

    1999-05-01

    Otto Rank's will therapy helped shape the ideas and techniques of relationship therapy developed by the Philadelphia social workers Jessie Taft, Virginia Robinson, and Frederick Allen in the 1930s. Rank's work and these ideas and techniques in turn strongly influenced the formulation of Carl Rogers' person-centered psychotherapy. This article compares and contrasts will, relationship, and person-centered approaches to psychotherapy and discusses the social factors--primarily the professional conflicts between a male-dominated psychiatry and female social workers over the independent practice of psychotherapy--that were crucial in the dissemination of Rank's psychological thought and the early popularity of Rogers. PMID:11623737

  8. A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias

    PubMed Central

    Cortes, J.E.; Kim, D.-W.; Pinilla-Ibarz, J.; le Coutre, P.; Paquette, R.; Chuah, C.; Nicolini, F.E.; Apperley, J.F.; Khoury, H.J.; Talpaz, M.; DiPersio, J.; DeAngelo, D.J.; Abruzzese, E.; Rea, D.; Baccarani, M.; Müller, M.C.; Gambacorti-Passerini, C.; Wong, S.; Lustgarten, S.; Rivera, V.M.; Clackson, T.; Turner, C.D.; Haluska, F.G.; Guilhot, F.; Deininger, M.W.; Hochhaus, A.; Hughes, T.; Goldman, J.M.; Shah, N.P.; Kantarjian, H.

    2013-01-01

    BACKGROUND Ponatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated BCR-ABL, including BCR-ABL with the tyrosine kinase inhibitor–refractory threonine-to-isoleucine mutation at position 315 (T315I). We conducted a phase 2 trial of ponatinib in patients with chronic myeloid leukemia (CML) or Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph-positive ALL). METHODS We enrolled 449 heavily pretreated patients who had CML or Ph-positive ALL with resistance to or unacceptable side effects from dasatinib or nilotinib or who had the BCR-ABL T315I mutation. Ponatinib was administered at an initial dose of 45 mg once daily. The median follow-up was 15 months. RESULTS Among 267 patients with chronic-phase CML, 56% had a major cytogenetic response (51% of patients with resistance to or unacceptable side effects from dasatinib or nilotinib and 70% of patients with the T315I mutation), 46% had a complete cytogenetic response (40% and 66% in the two subgroups, respectively), and 34% had a major molecular response (27% and 56% in the two subgroups, respectively). Responses were observed regardless of the baseline BCR-ABL kinase domain mutation status and were durable; the estimated rate of a sustained major cytogenetic response of at least 12 months was 91%. No single BCR-ABL mutation conferring resistance to ponatinib was detected. Among 83 patients with accelerated-phase CML, 55% had a major hematologic response and 39% had a major cytogenetic response. Among 62 patients with blast-phase CML, 31% had a major hematologic response and 23% had a major cytogenetic response. Among 32 patients with Ph-positive ALL, 41% had a major hematologic response and 47% had a major cytogenetic response. Common adverse events were thrombocytopenia (in 37% of patients), rash (in 34%), dry skin (in 32%), and abdominal pain (in 22%). Serious arterial thrombotic events were observed in 9% of patients; these events were considered to be treatment-related in 3

  9. Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?

    PubMed Central

    Bjork, J; Albin, M; Welinder, H; Tinnerberg, H; Mauritzson, N; Kauppinen, T; Stromberg, U; Johansson, B; Billstrom, R; Mikoczy, Z; Ahlgren, T; Nilsson, P; Mitelman, F; Hagmar, L

    2001-01-01

    OBJECTIVES—To investigate a broad range of occupational, hobby, and lifestyle exposures, suggested as risk factors for Philadelphia chromosome positive (Ph+) chronic myeloid leukaemia (CML).
METHODS—A case-control study, comprising 255 Ph+CML patients from southern Sweden and matched controls, was conducted. Individual data on work tasks, hobbies, and lifestyle exposures were obtained by telephone interviews. Occupational hygienists assessed occupational and hobby exposures for each subject individually. Also, occupational titles were obtained from national registries, and group level exposure—that is, the exposure proportion for each occupational title—was assessed with a job exposure matrix. The effects of 11 exposures using individual data and two exposures using group data (organic solvents and animal dust) were estimated.
RESULTS—For the individual data on organic solvents, an effect was found for moderate or high intensity of exposure (odds ratio (OR) 3.4, 95% confidence interval (95% CI) 1.1 to 11) and for long duration (15-20 years) of exposure (OR 2.1, 95% CI 1.1 to 4.0). By contrast, the group data showed no association (OR 0.69, 95% CI 0.27 to 1.8; moderate or high intensity versus no exposure). For extremely low frequency electromagnetic fields (EMFs), only individual data were available. An association with long occupational exposure to EMFs was found (OR 2.3, 95% CI 1.2 to 4.5). However, no effect of EMF intensity was indicated. No significant effects of benzene, gasoline or diesel, or tobacco smoking were found. OR estimates below unity were suggested for personal use of hair dye and for agricultural exposures.
CONCLUSIONS—Associations between exposure to organic solvents and EMFs, and Ph+CML were indicated but were not entirely consistent.


Keywords: risk factors; epidemiology; case-control study PMID:11600728

  10. Philadelphia's community based drug abuse program: broader medical and social concepts.

    PubMed

    Schut, J

    1975-06-01

    The rehabilitation of drug dependent people has undergone drastic changes since first attempts were made to curb the abuse of illegal drugs. The isolated law-enforcement model proved to be of no use in this area. So, too, the medical model, the psychological model and the public health model proved disappointingly low in their results. During the last ten years, a so-called "metabolic replacement model" has had its upsurge, creating a controversy still under discussion. The Drug Abuse Rehabilitation Programs of the West Philadelphia Community Mental Health Consortium, Inc. have been in the forefront with its treatment models. Established in 1968 as a purely methadone maintenance program, it has evolved into becoming a model, applying community mental health principles. This paper will explore this model further, describing the mechanics of its changes. From a municipal hospital-based methadone dispensing station, the program has developed into a multi-modality project. Three decentralized drug-free outpatient services are located in the midst of the community where the drug abuse problem is more accute. Outreach is emphasized and case-funding is applied. A possibly unique river-front motel was just acquired for the development of a community-based treatment modality. The 94 rooms were converted into a first-floor alcoholism program which also has a "highway safety program" and an intermediate care facility for alcoholics. The second floor of this facility contains outpatient services for the treatment of drug addicts, including a methadone maintenance program, counselling, family therapy and group therapy. The place where most of the emphasis has been placed is the Work Rehabilitation Center (a novel approach whereby patients will spend up to six hours in "partial hospitalization"). Clients will be tested for vocational aptitude and four workshops will be developed on the premises - carpentry, automotive, electricity and clerical. A huge cafeteria with a semi

  11. The Effect of Philadelphia and Pennsylvania Clean Indoor Air Act on Food Services and Drinking Places Sales and Numbers, 1998-2011

    PubMed Central

    Fisher, Monica A.

    2013-01-01

    Introduction Philadelphia enacted its Clean Indoor Air Act (CIAA) nearly 2 years before the statewide CIAA. In this study, we assessed the economic impact of CIAAs on 4 types of food services and drinking places and addressed the predominant limitation of previous pre–post ban studies, namely the lack of control for confounders and changes in secular trends over time. Methods We analyzed data from Pennsylvania Department of Revenue Quarterly 1998–2011 taxable county-level revenue sales and number of food services and drinking places. Region-specific and type-specific adjusted sales and number of food services and drinking places accounted for consumer spending as a general economic indicator. Segmented regression analysis of interrupted time-series methodology assessed changes in trend and level. Results Pennsylvania CIAA had no significant effect on adjusted sales or numbers except for an increase in sales in Philadelphia for limited-service eating places and in the surrounding 4 counties for special food services. Philadelphia CIAA was associated with an increase in adjusted numbers of full-service restaurants in Philadelphia and the rest of the state, special food services in Philadelphia, and drinking places in the rest of the state, and a decrease in the number of special food services in the surrounding counties. Philadelphia CIAA had no significant effect on adjusted sales except for an increase in special food services in the rest of the state. Conclusion Overall, CIAAs had no negative business-related impact and, for the most part, suggest a positive impact on restaurant sales and numbers. Our results provide further support for comprehensive CIAA ordinance for restaurants. PMID:24286275

  12. Secondary chromosomal changes in 34 Philadelphia-chromosome-positive chronic myelocytic leukemia patients from the Mexican West.

    PubMed

    Meza Espinoza, Juan Pablo; Judith Picos Cárdenas, Verónica; Gutiérrez-Angulo, Melva; González García, Juan Ramón

    2004-01-15

    The clonal evolution in t(9;22)-positive chronic myelocytic leukemia (CML) is well established. Four major changes occur in more than 70% of patients: +8, i(17q), +19, and an extra Philadelphia chromosome. The frequencies of secondary chromosomal changes in 34 patients from the states of Jalisco, Nayarit, Michoacán, and Colima (the Mexican West) with Philadelphia-chromosome-positive CML were assessed. The most frequent abnormalities were tetraploidy (12 cases); +8, inv(3)(q21q26), and octoploidy (3 cases each); and +der(22)(2 cases). Some translocations not previously associated with CML were observed, such as t(2;7)(p12;q36), t(3;6)(q26;p25), t(3;17)(q26;p13), and t(6;17)(q21;q23 approximately q25). Significant differences were found for +8 with respect to population results from Japan and from southern, eastern, and western Europe; for i(17)(q10) from eastern Europe; for +19 from Japan and western Europe; and for +der(22) from Japan, southern Europe, and western Europe. Although polyploidy could result from endomitosis, there is no direct evidence that the BCR/ABL protein influences such a process; however, protein kinases such as MAPK, which are involved in endomitosis, are activated by the BCR/ABL protein, and so the BCR/ABL protein could promote endomitosis through the MAPK pathway.

  13. Mode of Delivery among HIV-Infected Pregnant Women in Philadelphia, 2005-2013

    PubMed Central

    Adams, Joëlla W.; Anderson, Emily A.

    2015-01-01

    Objective Current guidelines call for HIV-infected women to deliver via scheduled Caesarean when the maternal HIV viral load (VL) is >1,000 copies/ml. We describe the mode of delivery among HIV-infected women and evaluate adherence to relevant recommendations. Study Design We performed a population-based surveillance analysis of HIV-infected pregnant women in Philadelphia from 2005 to 2013, comparing mode of delivery (vaginal, scheduled Caesarean, or emergent Caesarean) by VL during pregnancy, closest to the time of delivery (≤1,000 copies/ml versus an unknown VL or VL >1,000 copies/ml) and associated factors in multivariable analysis. Results Our cohort included 824 deliveries from 648 HIV-infected women, of whom 69.4% had a VL ≤1,000 copies/ml and 30.6% lacked a VL or had a VL >1,000 copies/ml during pregnancy, closest to the time of delivery. Mode of delivery varied by VL: 56.6% of births were vaginal, 30.1% scheduled Caesarean, and 13.3% emergent Caesarean when the VL was ≤1,000 copies/ml; when the VL was unknown or >1,000 copies/ml, 32.9% of births were vaginal, 49.9% scheduled Caesarean and 17.5% emergent Caesarean. In multivariable analyses, Hispanic women (adjusted odds ratio (AOR) 0.17, 95% Confidence Interval (CI) 0.04–0.76) and non-Hispanic black women (AOR 0.27, 95% CI 0.10–0.77) were less to likely to deliver via scheduled Caesarean compared to non-Hispanic white women. Women who delivered prior to 38 weeks’ gestation (AOR 0.37, 95% CI 0.18–0.76) were also less likely to deliver via scheduled Caesarean compared to women who delivered after 38 weeks’ gestation. An interaction term for race and gestational age at delivery was significant in multivariable analysis. Non-Hispanic black (AOR 0.06, 95% CI 0.01–0.36) and Hispanic women (AOR 0.03, 95% CI 0.00–0.59) were more likely to deliver prematurely and less likely to deliver via scheduled C-section compared to non-Hispanic white women. Having a previous Caesarean (AOR 27.77, 95% CI 8

  14. Factors Influencing the Successful Completion of the General Education Development (GED) Program at Community College of Philadelphia as Perceived by the GED Students.

    ERIC Educational Resources Information Center

    Tucho, Admasu Etefa

    This study determined which of three types of educational barriers (institutional, situational, or dispositional) represented the major problem preventing adult students from completing their general educational development (GED) studies at Community College of Philadelphia (CCP) in Pennsylvania. A Likert-type survey instrument was used to collect…

  15. Variations on a Theme: The Shift from Distinction to Commonality in Philadelphia's Diverse Provider Model 2002-2008

    ERIC Educational Resources Information Center

    Bulkley, Katrina E.; Travers, Eva

    2013-01-01

    Recent years have seen a growing push toward Portfolio Management Models that incorporate a variety of "providers" operating public schools. One rationale for this is that such organizations can offer distinct and innovative educational practices. This article describes the Diverse Provider Model implemented in Philadelphia from…

  16. Soaring to Excellence. Proceedings of the Annual North East Association for Institutional Research (NEAIR) Conference (33rd, Philadelphia, Pennsylvania, November 4-7, 2006)

    ERIC Educational Resources Information Center

    Alvord, Catherine, Ed.

    2006-01-01

    The NEAIR 2006 Conference Proceedings is a compilation of papers presented at the Philadelphia, Pennsylvania conference. Topics include: Policy Analysis, Grading Policy, State Higher Education Accountability Program, Performance Assessment, Freshmen Transfer Risk, Assessment, Degree Completion, First-Year Academic Success, Effectiveness in…

  17. WWC Quick Review of the Article "Impact of For-Profit and Nonprofit Management on Student Achievement: The Philadelphia Intervention, 2002-2008"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2010

    2010-01-01

    "Impact of For-Profit and Nonprofit Management on Student Achievement: The Philadelphia Intervention, 2002-2008" examined whether shifting from traditional district management to management by a for-profit or nonprofit organization improves student achievement. The study analyzed data on six cohorts of elementary and middle school students…

  18. A Description of the Structure, Functions, and Services of the Title IV-A Social Services Component in Philadelphia, 1974-1975. Report No. 7660.

    ERIC Educational Resources Information Center

    Asano, Mildred M.

    This report, representing the second half of a comprehensive study, presents descriptive data on the structure, functions, and services of the Social Services Component in Title IV-A Day Care in Philadelphia. Data were based on extensive interviews with 67 respondents representing 35 agencies. Two interviews, one each with a supervisor and a…

  19. A Profile of Social Service Personnel in Title IV-A Day Care in Philadelphia, 1974-1975. Report No. 7646.

    ERIC Educational Resources Information Center

    Asano, Mildred M.

    This report, representing the first half of a comprehensive study, describes the personnel of the Social Services Component in Title IV-A Day Care in Philadelphia and discusses some of the functions and services provided by these personnel. Data were based on responses from 129 service workers in 38 agencies. Respondents reported information on 21…

  20. Franklin's Philadelphia Academy and Basedow's Dessau Philanthropine: Two Models of Non-Denominational Schooling in Eighteenth-Century America and Germany

    ERIC Educational Resources Information Center

    Overhoff, Jurgen

    2007-01-01

    The Academy of Philadelphia (today known as the University of Pennsylvania), founded through Benjamin Franklin's influence in 1751, and the Dessau Philanthropine, founded by Johann Bernhard Basedow in 1774, were arguably the first non-denominational schools in the eighteenth century. Yet, the congenial educational ideas of their founders have…

  1. History and dating of the publication of the Philadelphia (1822) and London (1823) editions of Edwin James's Account of an expedition from Pittsburgh to the Rocky Mountains

    USGS Publications Warehouse

    Woodman, Neal

    2010-01-01

    The public record of Major Stephen H. Long's 1819–1820 exploration of the American north-west, Account of an expedition from Pittsburgh to the Rocky Mountains, compiled by Edwin James, contains valuable contributions regarding the natural landscapes, native peoples and wildlife of a mostly unexplored region of the American west compiled from the notes of some of America's foremost naturalists, and it includes the first descriptions of 67 new species. The original plan was to publish the Account in Philadelphia and London simultaneously, yet these two editions differ substantially in ways that are relevant to the taxonomic contributions in the work. It is generally assumed that the Philadelphia edition was published in early January 1823 and was available first, but little substantive evidence has been presented to support its priority over the London edition. Review of contemporary correspondence and periodicals indicates the Philadelphia edition was available and for sale on 31 December 1822, whereas the London edition was available in late February 1823. As previously assumed by most sources, the Philadelphia edition has priority of publication and is the authority for most species names. Its correct year of publication, however, is 1822 rather than 1823.

  2. Report on Task Force Division of School Facilities, School District of Philadelphia: Commission to Investigate Relationships between Educational Performance and Size of Student Body, May 11, 1970.

    ERIC Educational Resources Information Center

    Philadelphia School District, PA.

    The Philadelphia Art Commission refused to approve the proposed Eastwick/Pepper Educational Complex that combines a high school and a middle school into one facility. Their rejection was based on (1) the prohibitively large numbers of children the school is to serve, (2) the overly broad age span of the students, and (3) the inadequate outside…

  3. A Description of Room Arrangement, Design, and Appearance in Title IV-A Day Care Centers in Philadelphia, 1974-1975. Report No. 7733.

    ERIC Educational Resources Information Center

    Silber, Theodore J.

    This report describes the room arrangement, design, and appearance of 152 Title IV-A Day Care centers in Philadelphia. A series of 27 items on a section of the Daily Care, In-Room Observation Guide was used to provide an overall description of rooms in day care and to identify differences in features for different types of programs. Data were…

  4. Unlocking the Transformational Power of Continuing Education. Proceedings of the Annual Meeting of the Association for Continuing Higher Education (71st, Philadelphia, Pennsylvania, November 15-18, 2009)

    ERIC Educational Resources Information Center

    Jerman, Jerry, Ed.

    2009-01-01

    The 2009 proceedings of the Association for Continuing Higher Education represent the professional presentations of the keynote sessions, the concurrent sessions, and the business meeting of the association's 71st annual conference, held at the Sheraton Society Hill Hotel in Philadelphia on November 15-18, 2009. The conference provided an engaging…

  5. A door-to-door survey of bed bug (Cimex lectularius) infestations in row homes in Philadelphia, Pennsylvania.

    PubMed

    Wu, Yage; Tracy, Dylan M; Barbarin, Alexis M; Barbu, Corentin M; Levy, Michael Z

    2014-07-01

    We conducted a door-to-door survey in a residential census tract of Philadelphia to estimate the prevalence and spatial patterns of recent bed bug infestations. We interviewed 596 residents, of whom 66 (11.1%) reported recent bed bug infestations. We confirmed current infestations in a subset of 15 (68.2%) of 22 inspected households. Most residents reported that their infestation began within the past year (2012-2013). We found no correlation between property value and infestation status. Spatial analyses showed significant clustering of bed bug infestations only at fine scales, suggesting limited active dispersal of the insects. Residents used a large variety of treatment methods to eliminate bed bugs, but only 48.1% reported success. Our results provide a prevalence estimate of recent bed bug infestations and highlight the importance of passive rather than active dispersal of bed bugs even among dense urban row homes. PMID:24799372

  6. A Door-to-Door Survey of Bed Bug (Cimex lectularius) Infestations in Row Homes in Philadelphia, Pennsylvania

    PubMed Central

    Wu, Yage; Tracy, Dylan M.; Barbarin, Alexis M.; Barbu, Corentin M.; Levy, Michael Z.

    2014-01-01

    We conducted a door-to-door survey in a residential census tract of Philadelphia to estimate the prevalence and spatial patterns of recent bed bug infestations. We interviewed 596 residents, of whom 66 (11.1%) reported recent bed bug infestations. We confirmed current infestations in a subset of 15 (68.2%) of 22 inspected households. Most residents reported that their infestation began within the past year (2012–2013). We found no correlation between property value and infestation status. Spatial analyses showed significant clustering of bed bug infestations only at fine scales, suggesting limited active dispersal of the insects. Residents used a large variety of treatment methods to eliminate bed bugs, but only 48.1% reported success. Our results provide a prevalence estimate of recent bed bug infestations and highlight the importance of passive rather than active dispersal of bed bugs even among dense urban row homes. PMID:24799372

  7. The Philadelphia Health Insurance Organization: the results of managed health care for 96,000 medical assistance recipients.

    PubMed

    Temple, P C; Kron, S

    On March 1, 1986, an innovative Medicaid program serving 96,000 recipients began operation in Philadelphia, Pennsylvania. Known as the HealthPASS program, it changed the previous fee for service Medicaid program into a capitated, managed care "gatekeeper" system. The plan was administered through a Health Insurance Organization (HIO) designed cooperatively by the Pennsylvania Department of Welfare and a for-profit health maintenance organization. In its first year, the program enrolled over 500 physician case managers, saved the Commonwealth of Pennsylvania $20 million, instituted a quality assurance program with on-site audit of primary care physician office facilities and medical records, provided a 24-hour hotline, made available central case management for mental health care, and began to compile a comprehensive database to support medical case management.

  8. Revision of the Philadelphia Mindfulness Scale for measuring awareness and equanimity in Goenka's Vipassana meditation with Chinese Buddhists.

    PubMed

    Zeng, Xianglong; Li, Mengdan; Zhang, Bo; Liu, Xiangping

    2015-04-01

    Goenka's 10-day Vipassana course is a widespread mindfulness course rooted in traditional Buddhism. Awareness and equanimity are two abilities cultivated in this course that are not featured in modern mindfulness-based psychotherapies and thereby not adequately measured by current mindfulness scales. The present article analyzed the Philadelphia Mindfulness Scale (PHLMS; Cardaciotto et al. in Assessment 15(2):204-223, 2008) and revised it into a short version to avoid confusion when measuring awareness and equanimity. Empirical data obtained using Chinese university students and Chinese Buddhists showed that the psychometric properties of the original version of the PHLMS had low factor loading on some items and that the short version had improved psychometric properties, especially for Buddhists. The short PHLMS also exhibited reasonable relationships with emotional outcomes and meditation practices among Buddhists. Implications for the future application of the PHLMS among Buddhists were also discussed. PMID:24824919

  9. The Fielding H. Garrison Lecture: "Break-Bone" Fever in Philadelphia, 1780: Reflections on the History of Disease.

    PubMed

    Packard, Randall M

    2016-01-01

    In the Autumn of 1780 an epidemic hit the city of Philadelphia. The symptoms of the disease resembled those of present day dengue fever, and subsequent observers argued that the disease was in fact dengue. But was it? The question forces us to confront the challenges of retrospective epidemiology and how we examine the history of a disease. This paper examines the 1780 epidemic from two perspectives. First, it looks at evidence that the disease was dengue and examines what this tells us about the epidemic and the conditions that caused it. Second, it looks at the disease from the perspective of Dr. Benjamin Rush, who treated hundreds of patients during the epidemic. In other words, it examines the disease through the lens of eighteenth century medical ideas. The paper concludes that each approach is valuable and reveals different aspects of the relationship between society and disease.

  10. Using Qualified Energy Conservation Bonds for Public Building Upgrades. Reducing Energy Bills in the City of Philadelphia

    SciTech Connect

    Zimring, Mark

    2012-07-18

    Qualified Energy Conservation Bonds (QECBs) are federally-subsidized bonds that enable state, tribal, and local government issuers to borrow money to fund a range of energy conservation projects, including public building upgrades that reduce energy use by at least 20 percent, at very attractive borrowing rates and long terms. As part of the American Recovery and Reinvestment Act (ARRA), the City of Philadelphia received a $15 million QECB award from the U.S. Department of the Treasury (Treasury). The city leveraged $6.25 million of its QECB allocation to finance half of a $12.6 million initiative to upgrade the energy efficiency of City buildings. The upgrades to four city facilities are expected to deliver over $10 million of net savings, and are a major step towards achieving the city’s goal of reducing government energy consumption by 30 percent by 2015.

  11. [Prolonged molecular response induced by imatinib in Philadelphia positive acute lymphoblastic leukemia A case report and brief review].

    PubMed

    Raissi, Abderrahim; Bouaouad, Majdouline; Drideb, Noufissa Alami; Jennane, Selim; Mahtat, El Mahdi; Doghmi, Kamal; Mikdame, Mohammed

    2015-01-01

    Philadelphia or BCR-ABL positive acute lymphoblastic leukemia (PH+ ALL) is the most common and severe of adult ALL. The only potentially curator treatment remains allogeneic hematopoietic stem cells transplantation (SCT) in first complete remission. The use of imatinib has revolutionized the treatment of chronic myeloid leukemia. Its incorporation into PH + ALL protocols also improved the prognosis of this disease giving better complete remission rates compared to chemotherapy alone. The treatment of patients not eligible for SCT remains controversial. Prolonged use of high dose tyrosine kinase inhibitors (TKI) (ie: imatinib at 600 or 800 mg/j) as maintenance therapy seems to be a reasonable approach. We present a case of prolonged molecular remission of PH+ ALL under TKI alone as maintenance therapy.

  12. The Fielding H. Garrison Lecture: "Break-Bone" Fever in Philadelphia, 1780: Reflections on the History of Disease.

    PubMed

    Packard, Randall M

    2016-01-01

    In the Autumn of 1780 an epidemic hit the city of Philadelphia. The symptoms of the disease resembled those of present day dengue fever, and subsequent observers argued that the disease was in fact dengue. But was it? The question forces us to confront the challenges of retrospective epidemiology and how we examine the history of a disease. This paper examines the 1780 epidemic from two perspectives. First, it looks at evidence that the disease was dengue and examines what this tells us about the epidemic and the conditions that caused it. Second, it looks at the disease from the perspective of Dr. Benjamin Rush, who treated hundreds of patients during the epidemic. In other words, it examines the disease through the lens of eighteenth century medical ideas. The paper concludes that each approach is valuable and reveals different aspects of the relationship between society and disease. PMID:27374846

  13. The Effect of Selected Cleaning Techniques on Berkshire Lee Marble: A Scientific Study at Philadelphia City Hall

    USGS Publications Warehouse

    Mossotti, Victor G.; Eldeeb, A. Raouf; Fries, Terry L.; Coombs, Mary Jane; Naude, Virginia N.; Soderberg, Lisa; Wheeler, George S.

    2002-01-01

    This report describes a scientific investigation of the effects of eight different cleaning techniques on the Berkshire Lee marble component of the facade of the East Center Pavilion at Philadelphia City Hall; the study was commissioned by the city of Philadelphia. The eight cleaning techniques evaluated in this study were power wash (proprietary gel detergent followed by water rinse under pressure), misting (treatment with potable, nebulized water for 24-36 hours), gommage (proprietary Thomann-Hanry low-pressure, air-driven, small-particle, dry abrasion), combination (gommage followed by misting), Armax (sodium bicarbonate delivered under pressure in a water wash), JOS (dolomite powder delivered in a low-pressure, rotary-vortex water wash), laser (thermal ablation), and dry ice (powdered-dry-ice abrasion delivered under pressure). In our study approximately 160 cores were removed from the building for laboratory analysis. We developed a computer program to analyze scanning-electron-micrograph images for the microscale surface roughness and other morphologic parameters of the stone surface, including the near-surface fracture density of the stone. An analysis of more than 1,100 samples cut from the cores provided a statistical basis for crafting the essential elements of a reduced-form, mixed-kinetics conceptual model that represents the deterioration of calcareous stone in terms of self-organized soiling and erosion patterns. This model, in turn, provided a basis for identifying the variables that are affected by the cleaning techniques and for evaluating the extent to which such variables influence the stability of the stone. The model recognizes three classes of variables that may influence the soiling load on the stone, including such exogenous environmental variables as airborne moisture, pollutant concentrations, and local aerodynamics, and such endogenous stone variables as surface chemistry and microstructure (fracturing, roughness, and so on). This study

  14. Variability in the interaction of beta-thalassemia with the alpha-chain variants Hb G-Philadelphia and Hb Rampa.

    PubMed

    Huisman, T H; Gravely, M E; Henson, J; Felice, A; Wilson, J B; Abraham, E C; Vella, F; Little, M W

    1978-08-01

    Two unrelated families are reported in which beta-thalassemia trait occurred with a heterozygosity of Hb G-Philadelphia (alpha2 68(E17)Asn leads to Lys beta2) in one family and with Hb Rampa (alpha2 95(G2)Pro leads to Ser beta2) in the other. The percentage of Hb G-Philadelphia was not influenced by the simultaneous presence of a beta-thalassemai determinant, but that of Hb Rampa was descreased from 20% in the simple heterozygote to about 6% in persons with the Hb Rampa-beta-thalassemia combination. Data from in vitro recombination experiments with isolated alpha X, alpha A, and beta A chains, with heme attached, indicated a preferential formation of Hb A over Hb Rampa but not over Hb G-Philadelphia in conditions of relative beta-chain deficiency. This suggests that the rate of assembly of monomers to form dimers or tetramers can be an important mechanism of controlling the quantity of certain hemoglobin variants with critical substitutions in heterozygotes. PMID:681817

  15. Effect of Regional-Scale Transport on Oxidants in the Vicinity of Philadelphia During the 1999 NE-OPS Field Campaign

    SciTech Connect

    Fast, Jerome D.; Zaveri, Rahul A.; Bian, Randy X.; Chapman, Elaine G.; Easter, Richard C.

    2002-08-28

    A new meteorological-chemical modeling system is used to determine the relative contribution of regional-scale transport and local photochemical production on air quality over Philadelphia. The model performance is evaluated using surface and airborne meteorological and chemical measurements made during a 30-day period in July and August of 1999 as part of the Northeast Oxidant and Particulate Study (NE-OPS). Good agreement between the simulations and observations was obtained. The bias in the vicinity of Philadelphia over the simulation period was -5.8 ppb for the peak ozone mixing ratio during the day and 2.0 ppb for the minimum ozone mixing ratio at night. Layers of ozone above the convective boundary layer were measured by both research aircraft and ozonesondes during the morning between 09 and 11 EDT. The modeling system demonstrates that upwind vertical mixing processes the previous afternoon, subsequent horizontal transport aloft, and depletion of ozone by NO titration within the stable boundary layer at night lead to the development of these layers. Ozone aloft was then entrained into the growing convective boundary, contributing to surface ozone concentrations. Through a series of sensitivity studies, we find that most of the ozone is the result of emissions in the vicinity of Philadelphia and Chesapeake Bay area, but up to 30-40% of the ozone during high-ozone episodes was due to transport from upwind sources. Local emissions and meteorological conditions were largely responsible for one high-ozone episode because of light winds.

  16. Aberrant activation-induced cytidine deaminase expression in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia.

    PubMed

    Shi, Yang; Zhao, Xiaoxian; Durkin, Lisa; Rogers, Heesun Joyce; Hsi, Eric D

    2016-06-01

    Activation-induced cytidine deaminase (AID) is expressed in germinal center B cells and plays a critical role in somatic hypermutation and class-switch recombination of immunoglobulin genes. Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) carries a poor prognosis and is specifically treated with tyrosine kinase inhibitors. Interestingly, AID has been shown to be aberrantly expressed and functional in Ph+ ALL and is thought to contribute to genetic instability. We hypothesized that AID might be detectable in routinely processed bone marrow biopsies by immunohistochemistry (IHC) and assist in identifying Ph+ ALL. We found that AID was expressed in 26 (70%) of 37 cases of Ph+ ALL but only 1 (2.9%) of 38 cases of Ph- ALL cases. There was a significant difference in AID expression between these 2 ALL groups (P < .001, Fisher exact test). The expression of AID was confirmed by RT-PCR (reverse-transcriptase polymerase chain reaction) and correlated with IHC scoring. AID protein is expressed in a large proportion of Ph+ ALL cases at levels detectable by IHC in clinical samples and might be useful to rapidly identify cases likely to have a BCR/ABL1 fusion. PMID:26980048

  17. Prescription Drug Misuse and Sexual Risk Behaviors Among Young Men Who Have Sex With Men (YMSM) in Philadelphia

    PubMed Central

    Kecojevic, Aleksandar; Silva, Karol; Sell, Randall; Lankenau, Stephen E.

    2014-01-01

    This study examined the relationship between prescription drug misuse and sexual risk behaviors (i.e. unprotected sex, increased number of sex partners) in a sample of young men who have sex with men (YMSM) in Philadelphia. Data come from a cross-sectional study of 18-29 year old YMSM (N=191) who misused prescription drugs in the past 6 months. Associations were investigated in two regression models: logistic models for unprotected anal intercourse (UAI) and zero-truncated Poisson regression model for number of sex partners. Of 177 participants engaging in anal intercourse in the past 6 months, 57.6% engaged in UAI. After adjusting for socio-demographic variables and illicit drug use, misuse of prescription pain pills and muscle relaxants remained significantly associated with engaging in receptive UAI. No prescription drug class was associated with a high number of sex partners. This study provides additional evidence that some prescription drugs are associated with sexual risk behaviors among YMSM. PMID:25240627

  18. Low/medium Btu coal gasification assessment of central plant for the city of Philadelphia, Pennsylvania. Final report

    SciTech Connect

    Not Available

    1981-02-01

    The objective of this study is to assess the technical and economic feasibility of producing, distributing, selling, and using fuel gas for industrial applications in Philadelphia. The primary driving force for the assessment is the fact that oil users are encountering rapidly escalating fuel costs, and are uncertain about the future availability of low sulfur fuel oil. The situation is also complicated by legislation aimed at reducing oil consumption and by difficulties in assuring a long term supply of natural gas. Early in the gasifier selection study it was decided that the level of risk associated with the gasification process sould be minimal. It was therefore determined that the process should be selected from those commercially proven. The following processes were considered: Lurgi, KT, Winkler, and Wellman-Galusha. From past experience and a knowledge of the characteristics of each gasifier, a list of advantages and disadvantages of each process was formulated. It was concluded that a medium Btu KT gas can be manufactured and distributed at a lower average price than the conservatively projected average price of No. 6 oil, provided that the plant is operated as a base load producer of gas. The methodology used is described, assumptions are detailed and recommendations are made. (LTN)

  19. Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis

    PubMed Central

    Verstovsek, Srdan; Tefferi, Ayalew; Cortes, Jorge; O’Brien, Susan; Garcia-Manero, Guillermo; Pardanani, Animesh; Akin, Cem; Faderl, Stefan; Manshouri, Taghi; Thomas, Deborah; Kantarjian, Hagop

    2016-01-01

    Molecular characterization of Philadelphia chromosome-negative (Ph−) chronic myeloproliferative disorders, such as systemic mastocytosis (SM), has provided a clear rationale for investigating novel targeted therapies. The tyrosine kinase (TK) inhibitor dasatinib is 325-fold more potent against Bcr-Abl TK than imatinib in vitro, significantly inhibiting wild-type KIT and PDGFR-B TKs, and is active against cells carrying the mutant KIT-D816V gene. In this phase 2, open-label study, the efficacy of dasatinib (140 mg/day) was investigated in 67 patients with various Ph− myeloid disorders, including SM (N=33; 28 KIT-D816V positive). The overall response rate to dasatinib in patients with SM was 33%. Only two patients, one with SM-myelofibrosis and one with SM-chronic eosinophilic leukemia, achieved complete response (elimination of mastocytosis) lasting for 5 and 16 months, respectively. Both patients were negative for KIT-D816V mutation, had low tryptase levels, abnormal WBC counts, and anemia, and had failed prior therapy with erythropoietin. Additional 9 SM patients had symptomatic response, lasting 3 to 18+ months. Complete responses were achieved in two other patients (acute myeloid leukemia, hypereosinophilic syndrome). No responses were observed among patients with myelodysplastic syndromes and primary myelofibrosis. The majority of adverse events were grade 1/2. These data show that dasatinib may benefit a selected group of SM patients, primarily by improving their symptoms. PMID:18559612

  20. Imatinib-based therapy in adult Philadelphia chromosome-positive acute lymphoblastic leukemia: A case report and literature review

    PubMed Central

    ZHANG, LI; CHEN, MENG; FENG, BO; KUANG, PU; HE, PENG; LIU, TING; PAN, LING

    2015-01-01

    Acute lymphoblastic leukemia (ALL) has a rapid onset and rarely occurs with exclusive prodrome of general osteoporosis and vertebral compression fractures. However, Philadelphia chromosome-positive (Ph+) ALL has a poor prognosis, even when patients are treated with intensive chemotherapy, and the first-line effective treatment requires further elucidation. The present study focused on a 56-year-old Chinese male patient who initially presented with spontaneous bone fractures and was ultimately diagnosed as Ph+ ALL after 6 months, which required to preliminarily exclude a working diagnosis of myeloma. Apart from intensive chemotherapy, the patient successfully completed an imatinib-based regimen and achieved complete remission (CR) 2 weeks later. Subsequently, the patient was subjected to consolidation treatment using the same imatinib regimen combined with interferon-α 2b for 9 courses. In November 2013, the patient had achieved persistent hematological and molecular genetic normality for ~16 months after the initial CR. In conclusion, Ph+ ALL must be considered in the differential diagnosis of adults experiencing unexplained bone disease. PMID:26622794

  1. Circulating Cd34+ cell count differentiates primary myelofibrosis from other Philadelphia-negative myeloproliferative neoplasms: a pragmatic study.

    PubMed

    Orvain, C; Luque Paz, D; Dobo, I; Cottin, L; Le Calvez, G; Chauveau, A; Mercier, M; Farhi, J; Boyer, F; Ianotto, J C; Guibourg, B; Rousselet, M C; Zandecki, M; Ifrah, N; Hunault-Berger, M; Ugo, V; Genevieve, F

    2016-10-01

    A high number of circulating CD34+ cells has been advocated to distinguish primary myelofibrosis from other Philadelphia-negative myeloproliferative neoplasms. We re-evaluated the diagnostic interest of measuring circulating CD34+ cells in 26 healthy volunteers and 256 consecutive patients at diagnosis for whom a myeloproliferative neoplasm was suspected. The ROC curve analysis showed that a number of CD34+ <10/μl excludes the diagnosis of primary myelofibrosis with a sensitivity of 97 % and a specificity of 90 % (area under the curve: 0.93 [0.89-0.98]; p < 0.001). Patients with PMF harboring a CALR mutation had more circulating CD34+ cells than patients with either a JAK 2 or MPL mutation (p = 0.02 and p < 0.01, respectively). These results suggest that this fast, simple, non-invasive, and standardized test is of particular interest to exclude the diagnosis of primary myelofibrosis.

  2. A new reliable method for dimethyl sulfoxide analysis in wastewater: dimethyl sulfoxide in Philadelphia's three water pollution control plants.

    PubMed

    Cheng, Xianhao; Peterkin, Earl

    2007-05-01

    A simple but reliable procedure was developed to analyze dimethyl sulfoxide (DMSO) in wastewater. The isotope DMSO_d6 was used as the internal standard to ensure accuracy. The DMSO was reduced with stannous chloride and measured as dimethyl sulfide (DMS) with purge-and-trap gas chromatography/mass spectrometry. The method detection limit was at the sub-microgram-per-milliliter level; precision, as measured by standard deviation, was better than +/- 0.5%; and the recoveries were between 95 and 105% at the level of 2 microg/mL. The procedure could use standard analytical instrumentation used for volatile organic compound analysis. A field study was conducted to validate the method and quantify DMSO concentration range in the three water pollution control plants (WPCPs) in the city of Philadelphia, Pennsylvania. Results showed that, when a local chemical facility discharged, DMSO concentration could be as high as 12 mg/L in the influent to a WPCP. This would lead to the formation of a toxic "canned corn" DMS odor during the treatment processes. PMID:17571849

  3. In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

    SciTech Connect

    McLaughlin, J.; Chianese, E.; Witte, O.N.

    1987-09-01

    The Philadelphia chromosome is the cytogenetic hallmark of human chronic myelogenous leukemia. RNA splicing joins sequences from a gene on chromosome 22 (BCR) across the translocation breakpoint to a portion of the ABL oncogene from chromosome 9, resulting in a chimeric protein (P210) that is an active tyrosine kinase. Although strongly correlated with this specific human neoplasm, and implicated as an oncogene by analogy to the gene product of the Abelson murine leukemia virus, the P210 gene had not been tested directly for oncogenic potential in hematopoietic cells. The authors have used a retroviral gene-transfer system to express P210 in mouse bone marrow cells. When infected bone marrow is plated under conditions for long-term culture of cells of the B-lymphoid lineage, cells expressing high amounts of P210 tyrosine kinase dominate the culture and rapidly lead to clonal outgrowths of immature lymphoid cells. Expression of P210 is growth-stimulatory but not sufficient for full oncogenic behavior. Some clonal lines progress toward a fully malignant phenotype as judged by increased cloning efficiency in agar suspension and frequency and rapidity of tumor induction in syngeneic mice. Such in vitro systems should be useful in evaluating the sequential and perhaps synergistic involvement of the P210 gene and other oncogenes as models for the progressive changes observed in human chronic myelogenous leukemia.

  4. Circulating Cd34+ cell count differentiates primary myelofibrosis from other Philadelphia-negative myeloproliferative neoplasms: a pragmatic study.

    PubMed

    Orvain, C; Luque Paz, D; Dobo, I; Cottin, L; Le Calvez, G; Chauveau, A; Mercier, M; Farhi, J; Boyer, F; Ianotto, J C; Guibourg, B; Rousselet, M C; Zandecki, M; Ifrah, N; Hunault-Berger, M; Ugo, V; Genevieve, F

    2016-10-01

    A high number of circulating CD34+ cells has been advocated to distinguish primary myelofibrosis from other Philadelphia-negative myeloproliferative neoplasms. We re-evaluated the diagnostic interest of measuring circulating CD34+ cells in 26 healthy volunteers and 256 consecutive patients at diagnosis for whom a myeloproliferative neoplasm was suspected. The ROC curve analysis showed that a number of CD34+ <10/μl excludes the diagnosis of primary myelofibrosis with a sensitivity of 97 % and a specificity of 90 % (area under the curve: 0.93 [0.89-0.98]; p < 0.001). Patients with PMF harboring a CALR mutation had more circulating CD34+ cells than patients with either a JAK 2 or MPL mutation (p = 0.02 and p < 0.01, respectively). These results suggest that this fast, simple, non-invasive, and standardized test is of particular interest to exclude the diagnosis of primary myelofibrosis. PMID:27582015

  5. Estimation of flood-frequency characteristics and the effects of urbanization for streams in the Philadelphia, Pennsylvania area.

    USGS Publications Warehouse

    Bailey, J.F.; Thomas, W.O., Jr.; Wetzel, K.L.; Ross, T.J.

    1989-01-01

    This report provides a method for estimating the magnitude and frequency of floods for small streams in the Philadelphia, Pennsylvania area. Data collected at 21 streamflow gaging stations were used in a multiple-regression analysis to develop equations for computation of peak-flow characteristics. The flood equations were determined by relating flood-frequency characteristics computed using observed flow data from 13 stations and synthetically derived flow data from 8 stations to measurable basin characteristics. Significant characteristics in the equations are drainage area and impervious cover. Standard errors of estimate for the regression equations ranged from 38 to 43 percent. The equations can be used to determine peak-flow characteristics and to estimate the effect of urbanization on small streams with drainage areas from 1.1 to 64 square miles. The analyses indicate that increasing impervious area can significaantly increase peak flows. Examples are given for computing flood frequency for a site on an ungaged stream for an ungaged site on a gaged stream.

  6. Comparison of geographic methods to assess travel patterns of persons diagnosed with HIV in Philadelphia: how close is close enough?

    PubMed

    Eberhart, Michael G; Share, Amanda M; Shpaner, Mark; Brady, Kathleen A

    2015-02-01

    Travel distance to medical care has been assessed using a variety of geographic methods. Network analyses are less common, but may generate more accurate estimates of travel costs. We compared straight-line distances and driving distance, as well as average drive time and travel time on a public transit network for 1789 persons diagnosed with HIV between 2010 and 2012 to identify differences overall, and by distinct geographic areas of Philadelphia. Paired t-tests were used to assess differences across methods, and analysis of variance was used to assess between-group differences. Driving distances were significantly longer than straight-line distances (p<0.001) and transit times were significantly longer than driving times (p<0.001). Persons living in the northeast section of the city traveled greater distances, and at greater cost of time and effort, than persons in all other areas of the city (p<0.001). Persons living in the northwest section of the city traveled farther and longer than all other areas except the northeast (p<0.0001). Network analyses that include public transit will likely produce a more realistic estimate of the travel costs, and may improve models to predict medical care outcomes.

  7. Prescription Drug Misuse and Sexual Risk Behaviors Among Young Men Who have Sex with Men (YMSM) in Philadelphia.

    PubMed

    Kecojevic, Aleksandar; Silva, Karol; Sell, Randall L; Lankenau, Stephen E

    2015-05-01

    This study examined the relationship between prescription drug misuse and sexual risk behaviors (i.e. unprotected sex, increased number of sex partners) in a sample of young men who have sex with men (YMSM) in Philadelphia. Data come from a cross-sectional study of 18-29 year old YMSM (N = 191) who misused prescription drugs in the past 6 months. Associations were investigated in two regression models: logistic models for unprotected anal intercourse (UAI) and zero-truncated Poisson regression model for number of sex partners. Of 177 participants engaging in anal intercourse in the past 6 months, 57.6 % engaged in UAI. After adjusting for socio-demographic variables and illicit drug use, misuse of prescription pain pills and muscle relaxants remained significantly associated with engaging in receptive UAI. No prescription drug class was associated with a high number of sex partners. This study provides additional evidence that some prescription drugs are associated with sexual risk behaviors among YMSM. PMID:25240627

  8. BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review.

    PubMed

    An, Xin; Tiwari, Amit K; Sun, Yibo; Ding, Pei-Rong; Ashby, Charles R; Chen, Zhe-Sheng

    2010-10-01

    Chronic Myeloid Leukemia (CML) is a clonal disease characterized by the presence of the Philadelphia (Ph+) chromosome and its oncogenic product, BCR-ABL, a constitutively active tyrosine kinase, that is present in >90% of the patients. Epidemiologic data indicates that almost 5000 new cases are reported every year and 10% of these patients eventually succumb to the disease. The treatment of CML was revolutionized by the introduction of imatinib mesylate (IM, Gleevec), a BCR-ABL tyrosine kinase inhibitor (TKI). The clinical use of specific BCR-ABL inhibitors has resulted in a significantly improved prognosis, response rate, overall survival, and patient outcome in CML patients compared to previous therapeutic regimens. However, the complete eradication of CML in patients receiving imatinib was limited by the emergence of resistance mostly due to mutations in the ABL kinase domain and to a lesser extent by molecular residual disease after treatment. The second-generation BCR-ABL TKIs nilotinib (Tasigna) and dasatinib (Sprycel), showed significant activity in clinical trials in patients intolerant or resistant to imatinib therapy, except in those patients with the T315I BCR-ABL mutation. Identifying key components involved in the CML pathogenesis may lead to the exploration of new approaches that might eventually overcome resistance mediated to the BCR-ABL TKIs. Here, we present an overview about the current treatment of Ph+ CML patients with the TKIs and the obstacles to successful treatment with these drugs.

  9. Unbiased pro-thrombotic features at diagnosis in 977 thrombocythemic patients with Philadelphia-negative chronic myeloproliferative neoplasms.

    PubMed

    Gugliotta, Luigi; Iurlo, Alessandra; Gugliotta, Gabriele; Tieghi, Alessia; Specchia, Giorgina; Gaidano, Gianluca; Scalzulli, Potito R; Rumi, Elisa; Dragani, Alfredo; Martinelli, Vincenzo; Santoro, Cristina; Randi, Maria Luigia; Tagariello, Giuseppe; Candoni, Anna; Cattaneo, Daniele; Ricco, Alessandra; Palmieri, Raffaele; Liberati, Marina A; Langella, Maria; Rago, Angela; Bergamaschi, Micaela; Monari, Paola; Miglio, Rossella; Santoro, Umberto; Cacciola, Rossella; Rupoli, Serena; Mastrullo, Lucia; Musto, Pellegrino; Mazzucconi, Maria Gabriella; Vignetti, Marco; Cortelezzi, Agostino; Vianelli, Nicola; Martino, Bruno; De Stefano, Valerio; Passamonti, Francesco; Vannucchi, Alessandro M

    2016-07-01

    In patients with Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), the anti-thrombotic and/or cytoreductive treatment in the follow-up may affect the evaluation of the pro-thrombotic weight of the clinical and biological characteristics at diagnosis. In order to avoid this potential confounding effect, we investigated the relationship between prior thrombosis (PrTh: thrombosis occurred before diagnosis and before treatment) and the characteristics at diagnosis in 977 thrombocythemic patients with MPN, reclassified according to the WHO 2008 criteria. PrTh occurred in 194 (19.9%) patients, with similar rates in the different MPNs. In multivariate analysis, PrTh rate was significantly related to minor thrombocytosis (platelets ≤700×10(9)/L), leukocytosis (leukocytes >10×10(9)/L), higher hematocrit (HCT >45%), JAK2 V617F mutation, older age, and cardiovascular risk factors (CVRFs). The highest PrTh rate (33.9%) was associated with the coexistence of minor thrombocytosis and leukocytosis. Of note, the inverse relationship between PrTh rate and platelet count is consistent with the hemostatic paradox of thrombocytosis. In conclusion, this analysis in MPN patients disclosed the unbiased characteristics at diagnosis with a pro-thrombotic effect. Moreover, it suggests that the optimal control of blood cells counts, and CVRFs might be of utmost importance in the prevention of thrombosis during the follow-up. PMID:27107744

  10. Clinical Outcome of Children With Newly Diagnosed Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Treated Between 1995 and 2005

    PubMed Central

    Aricò, Maurizio; Schrappe, Martin; Hunger, Stephen P.; Carroll, William L.; Conter, Valentino; Galimberti, Stefania; Manabe, Atsushi; Saha, Vaskar; Baruchel, André; Vettenranta, Kim; Horibe, Keizo; Benoit, Yves; Pieters, Rob; Escherich, Gabriele; Silverman, Lewis B.; Pui, Ching-Hon; Valsecchi, Maria Grazia

    2010-01-01

    Purpose In a previous analysis of 326 children with Philadelphia chromosome (Ph) –positive acute lymphoblastic leukemia (ALL) treated between 1986 and 1996, hematopoietic stem-cell transplantation from HLA-matched related donors, but not from unrelated donors, offered a superior outcome than chemotherapy alone. To evaluate the impact of recent improvements in chemotherapy and transplantation, we performed a similar analysis on patients treated in the following decade. Patients and Methods We analyzed 610 patients with Ph-positive ALL treated between 1995 and 2005 without tyrosine kinase inhibitor therapy. The median follow-up duration was 6.3 years. Results Complete remission was achieved in 89% of patients. The 7-year event-free survival and overall survival rates were superior in the present cohort compared with the previous cohort (32.0% ± 2.0% v 25.0% ± 3.0, respectively, P = .007; and 44.9% ± 2.2% v 36.0% ± 3.0%, respectively, P = .017). Compared with chemotherapy alone, transplantation with matched related donors or unrelated donors in first remission (325 patients) showed an advantage with increasing follow-up, suggesting greater protection against late relapses (hazard ratio at 5 years, 0.37; P < .001). In the multivariate Cox regression analysis accounting for treatment (transplantation v no transplantation), age, leukocyte count, and early response had independent impact on treatment outcome. Conclusion Clinical outcome of children and adolescents with Ph-positive ALL has improved with advances in transplantation and chemotherapy. Transplantations with matched related donors and unrelated donors were equivalent and offered better disease control compared with chemotherapy alone. Age, leukocyte count, and early treatment response were independent prognostic indicators. The results of this study will serve as a historical reference to evaluate the therapeutic impact of tyrosine kinase inhibitors on the outcome of Ph-positive ALL. PMID:20876426

  11. Revisiting a population-dynamic model of air pollution and daily mortality of the elderly in Philadelphia.

    PubMed

    Murray, Christian J; Lipfert, Frederick W

    2010-05-01

    Epidemiological studies find that elderly, susceptible, and previously impaired individuals are more sensitive to transient air pollution exposures than healthy persons. However, any associated changes in life expectancy remain largely unresolved. Murray and Nelson published a model of daily mortality and air pollution that addresses mortality displacement or harvesting by directly considering population dynamics on the basis of the assumption that a period of illness or frailty precedes most elderly deaths. The underlying concept is that a person's response to an environmental exposure also depends on his/her physiological ability to withstand stress at that time. They used Kalman filtering to estimate an unobservable quantity--the size of the frail subpopulation from which elderly (ages > or = 65 yr) nontraumatic deaths are assumed to derive. They found a small subpopulation, relatively robust to environmental variations over 14 yr, with remaining life expectancies of 8-31 days in this frail status. Here, this model and dataset are expanded to examine the ramifications in more detail (including seasonality), to consider peak ozone as an additional pollutant, and to consider remaining life expectancies of the this frail subpopulation on a daily basis. Previous studies of mortality displacement and of Philadelphia mortality-air-pollution associations are also summarized in general, and agreement with the Murray-Nelson model was found, thus supporting its validity. The estimated additional mortality associated with a given environmental exposure persists for a few days at most but is not always compensated by subsequent mortality deficits. It is concluded that the pollution-associated mortality increases of a few percent in this dataset are consistent with losses of remaining life expectancy of up to a few days. It is also recommended that a more complex population-dynamic model be implemented to examine the extent to which previous short-term environmental

  12. Would Targeting Increase Efficiency of Syphilis Partner Services Programs?—Data From New York City, Philadelphia, Texas, and Virginia

    PubMed Central

    Hoots, Brooke E.; Lewis, Felicia M.T.; Anschuetz, Greta; Schillinger, Julia A.; Blank, Susan; Foskey, Tammy; Stover, Jeffrey A.; Peterman, Thomas A.

    2016-01-01

    Background Targeted partner notification (PN), or limiting PN to groups in which efforts are most successful, has been suggested as a potentially cost-effective alternative to providing PN for all syphilis case-patients. The purpose of this study was to identify index case characteristics associated with highest yield partner elicitation and subsequent case finding to determine whether some groups could be reasonably excluded from PN efforts. Methods We examined index case characteristics and PN metrics from syphilis case management records of 4 sexually transmitted disease control programs—New York City, Philadelphia, Texas, and Virginia. Partner elicitation was considered successful when a case-patient named 1 or more partners during interview. Case finding was considered successful when a case-patient had 1 or more partners who were tested and had serologic evidence of syphilis exposure. Associations between case characteristics and proportion of pursued case-patients with successful partner elicitation and case finding were evaluated using χ2 tests. Results Successful partner elicitation and new case finding was most likely for index case-patients who were younger and diagnosed at public sexually transmitted disease clinics. However, most characteristics of index case-patients were related to success at only a few sites, or varied in the direction of the relationship by site. Other than late latent case-patients, few demographic groups had a yield far below average. Conclusions If implemented, targeted PN will require site-specific data. Sites may consider eliminating PN for late latent case-patients. The lack of demographic groups with a below average yield suggests that sites should not exclude other groups from PN. PMID:24825340

  13. Knowledge, perceptions, and behaviors related to salt use among Philadelphia Chinese take-out restaurant owners and chefs.

    PubMed

    Ma, Grace X; Shive, Steve; Zhang, Yolanda; Aquilante, Jennifer; Tan, Yin; Zhao, Mei; Solomon, Sara; Zhu, Steven; Toubbeh, Jamil; Colby, Lisa; Mallya, Giridhar; Zeng, Qiaoling

    2014-09-01

    Most of the sodium Americans consume comes from processed and restaurant foods. An upstream global strategy to promote health is to work with local restaurants to reduce sodium content in their food offerings, while accounting for food taste and economic considerations. In urban communities, Chinese take-out restaurants serve meals with large amounts of sodium and are clustered in low-income, racial/ethnic minority communities with a high prevalence of hypertension. The objective of this study is to assess baseline knowledge, attitudes, and behaviors related to sodium use/consumption among Chinese take-out owners and chefs recruited to participate in the Philadelphia Healthy Chinese Take-Out Initiative. A cross-sectional study of 221 Chinese take-out restaurants was conducted from August 2012 to February 2013. Items measured knowledge, attitudes, and behaviors related to salt use, salt consumption, and health. Most owners/chefs knew that excess sodium consumption contributes to high blood pressure but were less aware of other health effects and of major sources of sodium in the U.S. diet. The majority were willing and able to reduce sodium content in meals if customer demand could be maintained, and they desired training in food preparation, procurement, and marketing. Findings show a need to provide education, strategies, and support to Chinese take-out owners/chefs in preparing low-salt dishes. The results of this and future studies to reduce sodium content in meals by working with restaurant owners and chefs have global health promotion implications.

  14. High-Dose Vincristine Sulfate Liposome Injection for Advanced, Relapsed, and Refractory Adult Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia

    PubMed Central

    O'Brien, Susan; Schiller, Gary; Lister, John; Damon, Lloyd; Goldberg, Stuart; Aulitzky, Walter; Ben-Yehuda, Dina; Stock, Wendy; Coutre, Steven; Douer, Dan; Heffner, Leonard T.; Larson, Melissa; Seiter, Karen; Smith, Scott; Assouline, Sarit; Kuriakose, Philip; Maness, Lori; Nagler, Arnon; Rowe, Jacob; Schaich, Markus; Shpilberg, Ofer; Yee, Karen; Schmieder, Guenter; Silverman, Jeffrey A.; Thomas, Deborah; Deitcher, Steven R.; Kantarjian, Hagop

    2013-01-01

    Purpose Relapsed adult acute lymphoblastic leukemia (ALL) is associated with high reinduction mortality, chemotherapy resistance, and rapid progression leading to death. Vincristine sulfate liposome injection (VSLI), sphingomyelin and cholesterol nanoparticle vincristine (VCR), facilitates VCR dose-intensification and densification plus enhances target tissue delivery. We evaluated high-dose VSLI monotherapy in adults with Philadelphia chromosome (Ph) –negative ALL that was multiply relapsed, relapsed and refractory to reinduction, and/or relapsed after hematopoietic cell transplantation (HCT). Patients and Methods Sixty-five adults with Ph-negative ALL in second or greater relapse or whose disease had progressed following two or more leukemia therapies were treated in this pivotal phase II, multinational trial. Intravenous VSLI 2.25 mg/m2, without dose capping, was administered once per week until response, progression, toxicity, or pursuit of HCT. The primary end point was achievement of complete response (CR) or CR with incomplete hematologic recovery (CRi). Results The CR/CRi rate was 20% and overall response rate was 35%. VSLI monotherapy was effective as third-, fourth-, and fifth-line therapy and in patients refractory to other single- and multiagent reinduction therapies. Median CR/CRi duration was 23 weeks (range, 5 to 66 weeks); 12 patients bridged to a post-VSLI HCT, and five patients were long-term survivors. VSLI was generally well tolerated and associated with a low 30-day mortality rate (12%). Conclusion High-dose VSLI monotherapy resulted in meaningful clinical outcomes including durable responses and bridging to HCT in advanced ALL settings. The toxicity profile of VSLI was predictable, manageable, and comparable to standard VCR despite the delivery of large, normally unachievable, individual and cumulative doses of VCR. PMID:23169518

  15. Storing empty calories and chronic disease risk: snack-food products, nutritive content, and manufacturers in Philadelphia corner stores.

    PubMed

    Lucan, Sean C; Karpyn, Allison; Sherman, Sandy

    2010-05-01

    Corner stores are part of the urban food environment that may contribute to obesity and diet-related diseases, particularly for low-income and minority children. The snack foods available in corner stores may be a particularly important aspect of an urban child's food environment. Unfortunately, there is little data on exactly what snack foods corner stores stock, or where these foods come from. We evaluated snack foods in 17 Philadelphia corner stores, located in three ethnically distinct, low-income school neighborhoods. We recorded the manufacturer, calories, fat, sugar, and sodium for all snack items, excluding candy and prepared foods. We then compared the nutritive content of assessed snack items to established dietary recommendations and a school nutrition standard. In total, stores stocked 452 kinds of snacks, with only 15% of items common between all three neighborhoods. Total and unique snacks and snack food manufacturers varied by neighborhood, but distributions in snack type varied negligibly: overall, there were no fruit snacks, no vegetable snacks, and only 3.6% of all snacks (by liberal definition) were whole grain. The remainder (96.4% of snacks) was highly processed foods. Five of 65 manufacturers supplied 73.4% of all kinds of snack foods. Depending on serving size definition, 80.0-91.5% of snack foods were "unhealthy" (by the school nutrition standard), including seven of 11 wholegrain products. A single snack item could supply 6-14% of a day's recommended calories, fat, sugar, and sodium on average (or 56-169% at the extreme) for a "typical" child. We conclude that corner store snack food inventories are almost entirely unhealthful, and we discuss possible implications and next steps for research and intervention.

  16. Historical ground-water-flow patterns and trends in iron concentrations in the Potomac--Raritan--Magothy aquifer system in parts of Philadelphia, Pennsylvania, and Camden and Gloucester Counties, New Jersey

    USGS Publications Warehouse

    Sloto, Ronald A.

    2003-01-01

    The Potomac-Raritan-Magothy (PRM) aquifer system is an important sole-source ground-water supply in Camden and Gloucester Counties, N.J. Elevated iron concentrations are a persistent water-quality problem associated with ground water from the PRM. In Philadelphia, the PRM no longer is usable as a water supply because of highly elevated concentrations of iron (as high as 429 mg/L [milligrams per liter]), manganese (as high as 4 mg/L), and sulfate (as high as 1,720 mg/L). A strongly reducing environment in the PRM in south Philadelphia causes these constituents to be remobilized by reductive dissolution of the aquifer matrix. By the 1920s, ground-water pumping changed the natural ground-water-flow patterns, and ground water flowed toward pumping centers in Philadelphia. By 1940, recharge areas changed from the topographically high areas east of Trenton, N.J., to the outcrop area of the PRM in Philadelphia, and the Delaware River became a source of recharge instead of a point of ground-water discharge. By 1954, the cone of depression caused by pumping at the former Philadelphia Naval Ship Yard (PNSY) exceeded 50 feet below NGVD 29, and the direction of ground-water flow was from New Jersey toward Philadelphia. Because of highly elevated concentrations of iron and manganese, pumping at the former PNSY ceased in the mid-1960s. Beginning about 1951, increased ground-water withdrawals from the PRM in New Jersey reversed the hydraulic gradient so that ground-water flow was from Philadelphia toward New Jersey under the Delaware River, making Philadelphia a recharge area for the PRM aquifer system in parts of Camden and Gloucester Counties. By 1988, water levels in the lower aquifer of the PRM in New Jersey had declined to 103 feet below NAVD 88. In 1943, dissolved iron concentrations ranged from 0.07 to 0.6 mg/L at the former PNSY. By 1967 when the wells at the PNSY were abandoned, dissolved iron concentrations had reached 46 mg/L. Dissolved iron concentrations in water

  17. Prevalence, Disparities, and Trends in Obesity and Severe Obesity Among Students in the School District of Philadelphia, Pennsylvania, 2006–2013

    PubMed Central

    Mallya, Giridhar; Wagner, Amanda; Buehler, James W.

    2015-01-01

    Introduction Recent analyses suggest that increases in rates of childhood obesity have plateaued nationally and may be decreasing among certain populations and communities, including Philadelphia, Pennsylvania. We examined 7 years of data, including 3 years not previously reported, to assess recent trends in major demographic groups. Methods We analyzed nurse-measured data from the School District of Philadelphia for school years 2006–07 through 2012–13 to assess trends in obesity (body mass index [BMI] ≥95th percentile) and severe obesity (BMI ≥120% of the 95th percentile) among all children aged 5 to 18 years for whom measurements were recorded. Results Over 7 school years, the prevalence of childhood obesity declined from 21.7% to 20.3% (P = .01); the prevalence of severe obesity declined from 8.5% to 7.3% (P < .001). Declines were larger among boys than among girls and among African Americans and Asians than among non-Hispanic whites and Hispanics. Over the final 3 years of study, the prevalence of obesity continued to decrease significantly among boys (including African Americans and Asians) but increased significantly among Hispanic girls and girls in grades kindergarten through 5. At the end of the study period, Hispanics had the highest prevalence of obesity among boys (25.9%) and girls (23.0%). The prevalence of severe obesity continued to trend downward in boys and decrease significantly among girls (including African American girls) but remained highest among Hispanic boys (10.1%) and African American girls (8.3%). Conclusion The prevalence of obesity and severe obesity continued to decline among children in Philadelphia, but in some groups initial reductions were reversed in the later period. Further monitoring, community engagement, and targeted interventions are needed to address childhood obesity in urban communities. PMID:26292065

  18. The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia chromosome-negative myeloproliferative neoplasms

    PubMed Central

    2014-01-01

    Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs). We performed high resolution melting analysis and Sanger sequencing together with T-A cloning to elucidate the unique mutation profile of these genes, in Chinese patients with MPNs. Peripheral blood DNA samples were obtained from 80 patients with polycythemia vera (PV), 80 patients with essential thrombocytosis (ET) and 50 patients with primary myelofibrosis (PMF). Ten PV patients were identified with diverse JAK2 exon 12 mutations. Five novel JAK2 Exon 12 mutation patterns (M532V/E543G, N533D, M535I/H538Y/K549I, E543G and D544N) were described. JAK2 V617F was detected in 140 samples (66 PV, 45 ET and 29 PMF). JAK2 Exon 12 mutations were prevalent (13%) and variable in the Chinese patients. Compared with PV patients with JAK2 V617F mutations, PV patients with JAK2 exon 12 mutations had an earlier median onset of disease (P = 0.0013). MPL W515L/K mutations were discerned in 4 ET and 3 PMF patients. Two kinds of CALR mutation, c. 1179_1230del and c. 1234_1235insTTGTC were detected in 20 ET and 16 PMF patients. A novel CALR mutation pattern (c. 1173_1223del/c. 1179_1230del) was identified in 2 PMF samples. In addition, 17 scattered point mutations in CALR c.1153 to c.1255 were also detected in 13 cases with CALR frame-shifting variations and 2 cases without CALR frame-shifting variations. Female patients showed a predisposition to CALR mutations (P = 0.0035). Chinese Ph-negative MPN patients have a unique mutation landscape in the common molecular markers of MPN diagnosis. Validation of the molecular diagnostic pipeline should be emphasized since there is a considerable ethnical diversity in the molecular profiles of Ph-negative MPNs. PMID:25023898

  19. The Crisis in Home Health Care: Greater Need, Less Care. Hearing before the Special Committee on Aging. United States Senate, Ninety-Ninth Congress, Second Session (Philadelphia, PA, July 28, 1986).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document presents witnesses' testimonies and prepared statements from the Congressional hearing held in Philadelphia, Pennsylvania to examine reports of inappropriate, at times illegal, denials of critical home health care to sick older Americans. In his opening statement, Senator John Heinz presents examples of victims who were denied proper…

  20. Section 2: Case Studies of the Politics of Privatization: Bringing the Private into the Public--Changing the Rules of the Game and New Regime Politics in Philadelphia Public Education

    ERIC Educational Resources Information Center

    Bulkley, Katrina E.

    2007-01-01

    Substantial policy and political changes have resulted from a 2001 state takeover of the Philadelphia School District and the subsequent hiring of Paul Vallas as the district's new CEO. Using the lens of urban regime analysis, which emphasizes the importance of public and private actors in forming a governing coalition, this article analyzes the…

  1. Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias

    PubMed Central

    Curi, Dany A.; Beauchamp, Elspeth M.; Blyth, Gavin T.; Arslan, Ahmet Dirim; Donato, Nicholas J.; Giles, Francis J.; Altman, Jessica K.; Platanias, Leonidas C.

    2015-01-01

    We investigated the efficacy of targeting the PIM kinase pathway in Philadelphia chromosome-positive (Ph+) leukemias. We provide evidence that inhibition of PIM, with the pan-PIM inhibitor SGI-1776, results in suppression of classic PIM effectors and also elements of the mTOR pathway, suggesting interplay between PIM and mTOR signals. Our data demonstrate that PIM inhibition enhances the effects of imatinib mesylate on Ph+ leukemia cells. We also found that PIM inhibition results in suppression of leukemic cell proliferation and induction of apoptosis of Ph+ leukemia cells, including those resistant to imatinib mesylate. Importantly, inhibition of PIM results in enhanced suppression of primary leukemic progenitors from patients with CML. Altogether these findings suggest that pharmacological PIM targeting may provide a unique therapeutic approach for the treatment of Ph+ leukemias. PMID:26375673

  2. Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

    PubMed Central

    LIANG, YUN; DING, LUYIN; LI, XIAN; WANG, WEIQIN; ZHANG, XIAOHONG

    2015-01-01

    A preleukaemic phase, typified by transient pancytopenia, is a rare occurrence that usually affects children and adolescents. The present study reports the case of a 50-year-old woman with transient pancytopenia, which manifested as a fever, cough and severe anemia. Three weeks following treatment of pancytopenia with antibiotics, red blood cell and platelet transfusion, granulocyte colony-stimulating factor and human γ globulin, the condition of the patient was improved. However, 3 weeks following discharge from hospital, the patient was diagnosed with acute lymphoblastic leukemia (ALL) with complex chromosomal abnormalities, including Philadelphia chromosome and P190 breakpoint cluster region-ABL. Complete remission was achieved following one course of combination chemotherapy. In conclusion, adult ALL with pancytopenia as a preceding symptom is rare, difficult to diagnose early and easily misdiagnosed. In addition, the pathogenesis of ALL and the precipitating factors underlying this disease require further investigation. PMID:26788209

  3. The efficacy of a network intervention to reduce HIV risk behaviors among drug users and risk partners in Chiang Mai, Thailand and Philadelphia, US

    PubMed Central

    Latkin, Carl; Donnell, Deborah; Metzger, David; Sherman, Susan; Aramrattna, Apinun; Davis-Vogel, Annet; Quan, Vu Minh; Gandham, Sharavi; Vongchak, Tasanai; Perdue, Tom; Celentano, David

    2009-01-01

    Objectives This HIV Prevention Trials Network (HPTN) study assessed the efficacy of a network oriented peer education intervention to promote HIV risk reduction among injection drug users and their drug and sexual network members in Chiang Mai, Thailand and Philadelphia, US. Methods We enrolled 414 networks with 1123 participants, with 204 networks randomized to the treatment condition and 210 to the control. The experimental intervention consisted of six 2-hour small group peer-educator sessions and two booster sessions. Follow-up visits occurred every six months for up to 30 months. Results The number of participants reporting injection risk behaviors dropped dramatically between baseline and follow-up in both sites and both arms. The networks in the experimental condition in Philadelphia sustained statistically significant reductions in high risk injection behaviors: a 46% reduction in sharing cottons, 44% reduction in sharing cookers, 47% reduction in front and back loading and 51% reduction in injecting with people not known very well. There were no significant effects associated with the intervention on risk behaviors in Thailand. Conclusions The study results demonstrates that not only can IDUs reduce their own injection risk behaviors, but they can also engage in the critical community role of assisting their injection network members to reduce HIV injection risk behaviors. This HIV Prevention Trials Network study assessed the efficacy of a network-oriented peer education intervention promoting HIV risk reduction among injection drug users and their drug and sexual network members in Chiang Mai, Thailand and Philadelphia, USA. The study was designed to test impact on HIV infection, but the infection rate was low and study was terminated early. This paper reports efficacy on outcomes of self-reported HIV risk behaviors. We enrolled 414 networks with 1123 participants. The experimental intervention consisted of six small group peer-educator training sessions

  4. Evaluation of Group Genetic Ancestry of Populations from Philadelphia and Dakar in the Context of Sex-Biased Admixture in the Americas

    PubMed Central

    Stefflova, Klara; Dulik, Matthew C.; Pai, Athma A.; Walker, Amy H.; Zeigler-Johnson, Charnita M.; Gueye, Serigne M.; Schurr, Theodore G.; Rebbeck, Timothy R.

    2009-01-01

    Background Population history can be reflected in group genetic ancestry, where genomic variation captured by the mitochondrial DNA (mtDNA) and non-recombining portion of the Y chromosome (NRY) can separate female- and male-specific admixture processes. Genetic ancestry may influence genetic association studies due to differences in individual admixture within recently admixed populations like African Americans. Principal Findings We evaluated the genetic ancestry of Senegalese as well as European Americans and African Americans from Philadelphia. Senegalese mtDNA consisted of ∼12% U haplotypes (U6 and U5b1b haplotypes, common in North Africa) while the NRY haplotypes belonged solely to haplogroup E. In Philadelphia, we observed varying degrees of admixture. While African Americans have 9–10% mtDNAs and ∼31% NRYs of European origin, these results are not mirrored in the mtDNA/NRY pools of European Americans: they have less than 7% mtDNAs and less than 2% NRYs from non-European sources. Additionally, there is <2% Native American contribution to Philadelphian African American ancestry and the admixture from combined mtDNA/NRY estimates is consistent with the admixture derived from autosomal genetic data. To further dissect these estimates, we have analyzed our samples in the context of different demographic groups in the Americas. Conclusions We found that sex-biased admixture in African-derived populations is present throughout the Americas, with continual influence of European males, while Native American females contribute mainly to populations of the Caribbean and South America. The high non-European female contribution to the pool of European-derived populations is consistently characteristic of Iberian colonization. These data suggest that genomic data correlate well with historical records of colonization in the Americas. PMID:19946364

  5. Correlation between JAK2 allele burden and pulmonary arterial hypertension and hematological parameters in Philadelphia negative JAK2 positive myeloproliferative neoplasms. An Egyptian experience.

    PubMed

    Mattar, Mervat M; Morad, Mohammed Abdel Kader; El Husseiny, Noha M; Ali, Noha H; El Demerdash, Doaa M

    2016-10-01

    Myeloproliferative neoplasms are characterized by a common stem cell-derived clonal proliferation, but are phenotypically diverse. JAK2 is mutated (V617F) in more than 90 % of patients with polycythemia vera (PV) and approximately 60 % of patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF). Pulmonary arterial hypertension (PAH) is a major complication of several hematological disorders. Chronic myeloproliferative disorders associated with PAH have been included in group five for which the etiology is unclear and/or multifactorial. The aim of this study is to screen Egyptian Philadelphia negative JAK2 positive myeloproliferative neoplasm patients for the presence of PAH and its correlation with JAK2 allele burden. We also made a review for correlation of JAK2 allele with hematological parameters comparing our results to others. We enrolled 60 patients with Philadelphia negative myeloproliferative neoplasms. All patients enrolled in the study were subjected to laboratory and imaging workup in the form of CBC, liver, kidney profile, bone marrow examination, abdominal ultrasonography, and transthoracic echocardiography. Our results revealed that 7 patients out of 60 (11.67 %) had pulmonary arterial hypertension, 3 patients with PMF, 2 patients with PRV, and 2 patients with ET, and its correlation with JAK2 allele burden was not statistically significant. Correlation analysis between JAK2 V617F allele burden and other parameters revealed: statistical significant correlation with age, HB, HCT, PLT, UA, LDH, and splenic diameter but insignificant correlation with WBCs and PAH. Pulmonary arterial hypertension prevalence in our study was 11.67 % and no significant correlation with JAK 2 allele burden. Our study is the largest one up to our knowledge that studies the association between its prevalence and JAK2 burden.

  6. Correlation between JAK2 allele burden and pulmonary arterial hypertension and hematological parameters in Philadelphia negative JAK2 positive myeloproliferative neoplasms. An Egyptian experience.

    PubMed

    Mattar, Mervat M; Morad, Mohammed Abdel Kader; El Husseiny, Noha M; Ali, Noha H; El Demerdash, Doaa M

    2016-10-01

    Myeloproliferative neoplasms are characterized by a common stem cell-derived clonal proliferation, but are phenotypically diverse. JAK2 is mutated (V617F) in more than 90 % of patients with polycythemia vera (PV) and approximately 60 % of patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF). Pulmonary arterial hypertension (PAH) is a major complication of several hematological disorders. Chronic myeloproliferative disorders associated with PAH have been included in group five for which the etiology is unclear and/or multifactorial. The aim of this study is to screen Egyptian Philadelphia negative JAK2 positive myeloproliferative neoplasm patients for the presence of PAH and its correlation with JAK2 allele burden. We also made a review for correlation of JAK2 allele with hematological parameters comparing our results to others. We enrolled 60 patients with Philadelphia negative myeloproliferative neoplasms. All patients enrolled in the study were subjected to laboratory and imaging workup in the form of CBC, liver, kidney profile, bone marrow examination, abdominal ultrasonography, and transthoracic echocardiography. Our results revealed that 7 patients out of 60 (11.67 %) had pulmonary arterial hypertension, 3 patients with PMF, 2 patients with PRV, and 2 patients with ET, and its correlation with JAK2 allele burden was not statistically significant. Correlation analysis between JAK2 V617F allele burden and other parameters revealed: statistical significant correlation with age, HB, HCT, PLT, UA, LDH, and splenic diameter but insignificant correlation with WBCs and PAH. Pulmonary arterial hypertension prevalence in our study was 11.67 % and no significant correlation with JAK 2 allele burden. Our study is the largest one up to our knowledge that studies the association between its prevalence and JAK2 burden. PMID:27468853

  7. Assessment of contamination and misclassification biases in a randomized controlled trial of a social network peer education intervention to reduce HIV risk behaviors among drug users and risk partners in Philadelphia, PA and Chiang Mai, Thailand

    PubMed Central

    Simmons, Nicole; Donnell, Deborah; Ou, San-san; Celentano, David D.; Aramrattana, Apinun; Davis-Vogel, Annet; Metzger, David; Latkin, Carl

    2015-01-01

    Context Controlled trials of educational interventions are susceptible to contamination. Objectives To test a contamination measure based on recall of terms. Main study A randomized controlled trial of a social network peer education intervention among 1,123 injection drug users and risk partners in Philadelphia, PA and Chiang Mai, Thailand. Methods We assessed the recall of test, negative and positive control terms by intervention and control arm participants and compared the relative odds (OR) of recall of test vs. negative control terms between study arms. Results The contamination measure showed good discriminant ability only among participants from Chiang Mai. In Philadelphia there was no evidence of contamination and little evidence of diffusion. In Chiang Mai there was evidence of diffusion and contamination of 4 of 5 terms tested. Conclusions Network structure and peer education in Chiang Mai likely led to contamination. Recall of intervention materials can be a useful method to detect contamination in trials of educational interventions. PMID:25935214

  8. Assessment of contamination and misclassification biases in a randomized controlled trial of a social network peer education intervention to reduce HIV risk behaviors among drug users and risk partners in Philadelphia, PA and Chiang Mai, Thailand.

    PubMed

    Simmons, Nicole; Donnell, Deborah; Ou, San-San; Celentano, David D; Aramrattana, Apinun; Davis-Vogel, Annet; Metzger, David; Latkin, Carl

    2015-10-01

    Controlled trials of HIV prevention and care interventions are susceptible to contamination. In a randomized controlled trial of a social network peer education intervention among people who inject drugs and their risk partners in Philadelphia, PA and Chiang Mai, Thailand, we tested a contamination measure based on recall of intervention terms. We assessed the recall of test, negative and positive control terms among intervention and control arm participants and compared the relative odds of recall of test versus negative control terms between study arms. The contamination measures showed good discriminant ability among participants in Chiang Mai. In Philadelphia there was no evidence of contamination and little evidence of diffusion. In Chiang Mai there was strong evidence of diffusion and contamination. Network structure and peer education in Chiang Mai likely led to contamination. Recall of intervention materials can be a useful method to detect contamination in experimental interventions.

  9. A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia

    PubMed Central

    Seymour, J F; Kim, D W; Rubin, E; Haregewoin, A; Clark, J; Watson, P; Hughes, T; Dufva, I; Jimenez, J L; Mahon, F-X; Rousselot, P; Cortes, J; Martinelli, G; Papayannidis, C; Nagler, A; Giles, F J

    2014-01-01

    Aurora kinase overexpression has been observed in patients with hematologic malignancies. MK-0457, a pan-aurora kinase inhibitor that also inhibits the ABL T315I mutant, was evaluated to treat patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL) with the T315I mutation. Adults with Ph+ chronic phase (CP)-, accelerated phase (AP)- or blast phase (BP)-CML, or ALL and documented BCR-ABL T315I mutation were treated with a 5-day continuous infusion of MK-0457 administered every 14 days at 40 mg/m2/h, 32 mg/m2/h or 24 mg/m2/h. Fifty-two patients (CP, n=15; AP, n=14; BP, n=11; Ph+ ALL, n=12) were treated. Overall, 8% of patients achieved major cytogenetic response; 6% achieved unconfirmed complete or partial response; 39% had no response. Two patients (CP CML) achieved complete hematologic response. No patients with advanced CML or Ph+ ALL achieved major hematologic response. The most common adverse event (AE) was neutropenia (50%). The most common grade 3/4 AEs were neutropenia (46%) and febrile neutropenia (35%). MK-0457 demonstrated minimal efficacy and only at higher, intolerable doses; lower doses were tolerated and no unexpected toxicities were observed. These data will assist in the development of future aurora kinase inhibitors and in the selection of appropriate target patient populations. PMID:25127392

  10. Allogeneic transplantation is not superior to chemotherapy in most patients over 40 years of age with Philadelphia-negative acute lymphoblastic leukemia in first remission.

    PubMed

    Wolach, Ofir; Stevenson, Kristen E; Wadleigh, Martha; DeAngelo, Daniel J; Steensma, David P; Ballen, Karen K; Soiffer, Robert J; Antin, Joseph H; Neuberg, Donna S; Ho, Vincent T; Stone, Richard M

    2016-08-01

    Survival of patients ≥40 years of age with Philadelphia-negative acute lymphoblastic leukemia (ALL) remains poor with current therapeutic approaches. It is unknown whether allogeneic hematopoietic stem-cell transplantation (HSCT) in first remission confers a survival benefit compared to a chemotherapy-only approach. We retrospectively compared the outcome of patients >40 years treated with HSCT or chemotherapy alone in first remission (n = 40 in each cohort). Three-year overall survival (OS) and disease-free survival (DFS) were not significantly different between the chemotherapy-only and HSCT groups (OS, 46% [31-68] vs. 40% [27-59], P = 0.35; DFS, 31% [18-52] vs. 40% [27-59], P = 0.98). The 3-year cumulative incidence of relapse (CIR) and non-relapse mortality (NRM) were 61% [41-76] and 9% [2-21] for the chemotherapy-only group and 28% [15-43] and 32% [17-47] for the transplant group (CIR, P = 0.011; NRM, P = 0.014). Allogeneic transplantation for patients ≥40 years with Ph-negative ALL in first remission is associated with a lower CIR, but this benefit is offset by considerable NRM as compared with chemotherapy-only approach. HSCT may be beneficial in patients with high-risk disease features. Am. J. Hematol. 91:793-799, 2016. © 2016 Wiley Periodicals, Inc. PMID:27153389

  11. Exploring the role of gender norms in nutrition and sexual health promotion in a piloted school-based intervention: The Philadelphia Ujima™ experience.

    PubMed

    Núñez, Ana; Robertson-James, Candace; Reels, Serita; Jeter, Janay; Rivera, Hilda; Yusuf, Zena; Liu

    2015-08-01

    Perceptions of masculinity and femininity influence behaviors and can be identified in young children and adolescents (Brannon, 2004). Thus, adolescents' engagement in health risk or promoting behaviors is influenced by perceptions of masculinity and femininity and the differences in expectations, norms and responsibilities for girls and boys (WHO, 2007). Girls and boys have different needs, and gender-based interventions that consider similarities as well as differences are needed. A gender-based nutrition and sexual health promotion program was developed and piloted by the Philadelphia Ujima Coalition in a high school setting. To explore the gender differences in adolescents' perceptions of the influence of gender norms on weight, nutrition, physical activity, and sexual health and the implication of these differences in future gender-integrated health promotion programming for youth, a content analysis of student and facilitator debriefing forms were implemented for the participating schools. The content analysis was used to identify central themes, concepts gained, and overall impact of the intervention sessions. Overall, gender norms influence healthy eating practices and activity through influencing perceptions of body type in adolescents. Gender norms also influence sexual activity and decision making through influencing perceptions of beauty, masculinity, femininity, pressures and popular concepts related to sexual activity. Thus, interventions that address gender may more effectively promote health and wellness in adolescents.

  12. JAK2 V617F detected in two B-cell chronic lymphocytic leukemia patients without coexisting Philadelphia chromosome-negative myeloproliferative neoplasms: A report of two cases

    PubMed Central

    YANG, YI-NING; QIN, YOU-WEN; WANG, CHUN

    2014-01-01

    The JAK2 V617F mutation has been observed in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs), including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. This mutation has also been observed in a small number of other myeloid malignancies, such as acute myeloid leukemia, chronic myeloid leukemia and myelodysplastic syndrome. The JAK2 V617F allele has rarely been evaluated in lymphoproliferative disorders. In total, 28 JAK2 V617F-positive B-cell lymphocytic leukemia (B-CLL) patients have previously been reported and all presented with Ph-MPN concomitantly. However, following investigation of the JAK2 V617F mutation in 63 B-CLL patients at the Shanghai First People’s Hospital (Shanghai, China) between January 2008 and December 2012 via allele-specific polymerase chain reaction, two B-CLL patients without a history of Ph-MPN were identified to carry the JAK2 V617F allele. PMID:25013507

  13. Proceedings of the 34th International Conference in High Energy Physics (ICHEP08), Philadelphia, PA, 2008, eConf C080730, [hep-ph/0809.xxx

    SciTech Connect

    Lockyer, Nigel S.; Smith, AJ Stewart,; et. al.

    2008-09-01

    In 2004 a team from the University of Pennsylvania, Princeton University, and the Institute for Advanced Study proposed to host the 2008 International Conference on High Energy Physics (ICHEP) on the campus of the University of Pennsylvania in Philadelphia. The proposal was approved later that year by the C-11 committee of the International Union of Pure and Applied Physics. The Co-Chairs were Nigel S. Lockyer (U. Penn/TRIUMF) and A.J. Stewart Smith (Princeton); Joe Kroll of U. Penn served as Deputy Chair from 2007 on. Highlights of the proposal included 1. greatly increased participation of young scientists, women scientists, and graduate students 2. new emphasis on formal theory 3. increased focus on astrophysics and cosmology 4. large informal poster session (170 posters) in prime time 5. convenient, contiguous venues for all sessions and lodging 6. landmark locations for the reception and banquet. The conference program consisted of three days of parallel sessions and three days of plenary talks.

  14. Does weather confound or modify the association of particulate air pollution with mortality? An analysis of the Philadelphia data, 1973--1980

    SciTech Connect

    Samet, J.; Zeger, S.; Kelsall, J.; Xu, J.; Kalkstein, L.

    1998-04-01

    This report considers the consequences of using alternative approaches to controlling for weather and explores modification of air pollution effects by weather, as weather patterns could plausibly alter air pollution`s effect on health. The authors analyzed 1973--1980 total mortality data for Philadelphia using four weather models and compared estimates of the effects of TSP and SO{sub 2} on mortality using a Poisson regression model. Two synoptic categories developed by Kalkstein were selected--The Temporal Synoptic Index (TSI) and the Spatial Synoptic Classification (SSC)--and compared with (1) descriptive models developed by Schwartz and Dockery (S-D); and (2) LOESS, a nonparametric function of the previous day`s temperature and dew point. The authors considered model fit using Akaike`s Information Criterion (AIC) and changes in the estimated effects of TSP and SO{sub 2}. In the full-year analysis, S-D is better than LOESS at predicting mortality, and S-D and LOESS are better than TSI, as measured by AIC. When TSP or SO{sub 2} was fit alone, the results were qualitatively similar, regardless of how weather was controlled; when TSP and SO{sub 2} were fit simultaneously, the S-D and LOESS models give qualitatively different results than TSI, which attributes more of the pollution effect to SO{sub 2} than to TSP. Model fit is substantially poorer with TSI.

  15. Spectrum characteristics of Denver and Philadelphia ground clutter and the problem of distinguishing wind shear targets from moving clutter

    NASA Technical Reports Server (NTRS)

    Mackenzie, Anne I.

    1992-01-01

    Spectral analysis of 1991 wind shear flight data has provided information about the power spectral density, spectral width, and velocity of ground clutter detected by the wind shear radar at several major airports. Ground clutter must be recognized and separated from weather targets before wind shear can be computed. Information will be presented characterizing and comparing ground clutter and weather target spectra. The information includes (1) spectral widths of stationary ground clutter seen at various scan and tilt angles, (2) power spectral density and velocity of moving ground clutter relative to the stationary ground clutter, and (3) spectral widths and velocities of weather targets. A summary of numerical results in the form of histograms and example numerical results in the form of spectral plots are presented.

  16. Determination of time-of-travel, dispersion characteristics, and oxygen reaeration coefficients during low streamflows--Lower Tacony/Frankford Creek, Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Senior, Lisa A.; Gyves, Matthew C.

    2010-01-01

    Time-of-travel, dispersion characteristics, and oxygen reaeration coefficients were determined by use of dye and gas tracing for a 2-mile reach of Tacony/Frankford Creek in Philadelphia, southeastern Pennsylvania. The reach frequently has concentrations of dissolved oxygen (DO) below the water-quality standard of 4 milligrams per liter during warm months. Several large combined sewer overflows (CSOs), including one of the largest in Philadelphia (former Wingohocking Creek), discharge to the study reach in this urbanized watershed, affecting water quality and the timing and magnitude of storm peaks. In addition, a dam that commonly results in backwater conditions and reduced natural reaeration is present a few hundred feet from the end of the study reach. Time-of-travel and reaeration data were collected under base-flow conditions in August and September 2009 for three sub-reaches from Roosevelt Boulevard (U.S. Route 1) to Castor Avenue. Determination of traveltimes to the centroid of the dye cloud were needed for calculation of the reaeration coefficients. Results of the dye study in Tacony/Frankford Creek indicate that traveltimes were affected by the presence of man-made structures, such as the large scour hole and pool developed at the outfall of the T14 CSO and the dam, both of which reduce stream velocities. Mean stream velocities during the dye-tracer tests ranged from a maximum of 0.44 to 0.04 foot per second through a large pool. The dispersion efficiency of the stream was determined from relations between normalized unit concentrations to time to peak for use in water-quality modeling. Oxygen reaeration coefficients determined by a constant rate-injection method using propane as the tracer gas were as low as 0.04 unit per hour in a long pool affected by backwater conditions behind a dam. The highest reaeration coefficient was 2.29 units per hour for a steep-gradient reach with multiple winding channels through gravel deposits, just downstream of a large

  17. Phase II trial of hyper CVAD and dasatinib in patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia or blast phase chronic myeloid leukemia.

    PubMed

    Benjamini, Ohad; Dumlao, Theresa Liu; Kantarjian, Hagop; O'Brien, Susan; Garcia-Manero, Guillermo; Faderl, Stefan; Jorgensen, Jeffrey; Luthra, Rajyalakshmi; Garris, Rebecca; Thomas, Deborah; Kebriaei, Partow; Champlin, Richard; Jabbour, Elias; Burger, Jan; Cortes, Jorge; Ravandi, Farhad

    2014-03-01

    Dasatinib is a second generation tyrosine kinase inhibitor, with activity in imatinib resistant Ph-positive ALL.We have treated 34 patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia(ALL) (n519) or lymphoid blast phase of chronic myelogenous leukemia (CML-LB) (n515) with the combination of dasatinib and the hyper CVAD regimen. Prior regimens included hyper CVAD plus imatinib(n511, 4 had transplant in first CR), other combination chemotherapy (n512), monotherapy with kinase inhibitors other than dasatinib (n59), and investigational agents (n52). Pretreatment ABL mutations were noted in 10 patients. The overall response rate was 91%, with 24 patients (71%) achieving complete response(CR), and 7(21%) CR with incomplete platelet recovery (CRp). Two patients died during induction and one had progressive disease. Twenty-six patients (84%) achieved complete cytogenetic remission after one cycle of therapy. Overall, 13 patients (42%) achieved complete molecular response, and 11 patients (35%) had major molecular response (BCR-ABL/ABL<0.1%). Nine patients proceeded to allogeneic transplantation.Grades 3 and 4 toxicities included hemorrhage, pleural and pericardial effusions and infections. The median follow-up for patients with CML-LB is 37.5 months (range, 7–70 months) with a 3-year overall survival of 70%;68% remained in CR at 3 years. For ALL patients, the median follow-up is 52 months (range, 45–59 months)with a 3-year survival of 26%; 30% remain in CR at 3 years. The combination of Hyper CVAD regimen with dasatinib is effective in patients with relapsed Ph-positive ALL and CML-LB. PMID:24779033

  18. Creation of a retrospective job-exposure matrix using surrogate measures of exposure for a cohort of US career firefighters from San Francisco, Chicago and Philadelphia

    PubMed Central

    Dahm, Matthew M; Bertke, Stephen; Allee, Steve; Daniels, Robert D

    2015-01-01

    Objectives To construct a cohort-specific job-exposure matrix (JEM) using surrogate metrics of exposure for a cancer study on career firefighters from the Chicago, Philadelphia and San Francisco Fire Departments. Methods Departmental work history records, along with data on historical annual fire-runs and hours, were collected from 1950 to 2009 and coded into separate databases. These data were used to create a JEM based on standardised job titles and fire apparatus assignments using several surrogate exposure metrics to estimate firefighters’ exposure to the combustion byproducts of fire. The metrics included duration of exposure (cumulative time with a standardised exposed job title and assignment), fire-runs (cumulative events of potential fire exposure) and time at fire (cumulative hours of potential fire exposure). Results The JEM consisted of 2298 unique job titles alongside 16 174 fire apparatus assignments from the three departments, which were collapsed into 15 standardised job titles and 15 standardised job assignments. Correlations were found between fire-runs and time at fires (Pearson coefficient=0.92), duration of exposure and time at fires (Pearson coefficient=0.85), and duration of exposure and fire-runs (Pearson coefficient=0.82). Total misclassification rates were found to be between 16–30% when using duration of employment as an exposure surrogate, which has been traditionally used in most epidemiological studies, compared with using the duration of exposure surrogate metric. Conclusions The constructed JEM successfully differentiated firefighters based on gradient levels of potential exposure to the combustion byproducts of fire using multiple surrogate exposure metrics. PMID:26163543

  19. Minimal Residual Disease at First Achievement of Complete Remission Predicts Outcome in Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia

    PubMed Central

    Lai, Xiaoyu; Tan, Yamin; Zheng, Weiyan; Shi, Jimin; Zhao, Yanmin; Lin, Maofang; He, Jingsong; Cai, Zhen; Luo, Yi; Huang, He

    2016-01-01

    We evaluated the prognostic effect of minimal residual disease at first achievement of complete remission (MRD at CR1) in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). A total of 97 patients received treatment in our center between 2007 and 2012 were retrospectively reviewed in this study. Patients were divided into two arms according to the post-remission therapy (chemotherapy alone or allogeneic hematopoietic stem cell transplantation (allo-HSCT)) they received. MRD was detected by four-color flow cytometry. We chose 0.02% and 0.2% as the cut-off points of MRD at CR1 for risk stratification using receiver operating characteristic analysis. The 3-year overall survival (OS) and leukemia free survival (LFS) rates for the whole cohort were 46.2% and 40.5%. MRD at CR1 had a significantly negative correlation with survival in both arms. Three-year OS rates in the chemotherapy arm were 70.0%, 25.2%, 0% (P = 0.003) for low, intermediate, and high levels of MRD at CR1, respectively. Three-year OS rates in the transplant arm were 81.8%, 64.3%, 27.3% (P = 0.005) for low, intermediate, and high levels of MRD at CR1, respectively. Multivariate analysis confirmed that higher level of MRD at CR1 was a significant adverse factor for OS and LFS. Compared with chemotherapy alone, allo-HSCT significantly improved LFS rates in patients with intermediate (P = 0.005) and high (P = 0.022) levels of MRD at CR1, but not patients with low level of MRD at CR1 (P = 0.851). These results suggested that MRD at CR1 could strongly predict the outcome of adult ALL. Patients with intermediate and high levels of MRD at CR1 would benefit from allo-HSCT. PMID:27695097

  20. Improved Early Event-Free Survival With Imatinib in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

    PubMed Central

    Schultz, Kirk R.; Bowman, W. Paul; Aledo, Alexander; Slayton, William B.; Sather, Harland; Devidas, Meenakshi; Wang, Chenguang; Davies, Stella M.; Gaynon, Paul S.; Trigg, Michael; Rutledge, Robert; Burden, Laura; Jorstad, Dean; Carroll, Andrew; Heerema, Nyla A.; Winick, Naomi; Borowitz, Michael J.; Hunger, Stephen P.; Carroll, William L.; Camitta, Bruce

    2009-01-01

    Purpose Imatinib mesylate is a targeted agent that may be used against Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL), one of the highest risk pediatric ALL groups. Patients and Methods We evaluated whether imatinib (340 mg/m2/d) with an intensive chemotherapy regimen improved outcome in children ages 1 to 21 years with Ph+ ALL (N = 92) and compared toxicities to Ph− ALL patients (N = 65) given the same chemotherapy without imatinib. Exposure to imatinib was increased progressively in five patient cohorts that received imatinib from 42 (cohort 1; n = 7) to 280 continuous days (cohort 5; n = 50) before maintenance therapy. Patients with human leukocyte antigen (HLA) –identical sibling donors underwent blood and marrow transplantation (BMT) with imatinib given for 6 months following BMT. Results Continuous imatinib exposure improved outcome in cohort 5 patients with a 3-year event-free survival (EFS) of 80% ± 11% (95% CI, 64% to 90%), more than twice historical controls (35% ± 4%; P < .0001). Three-year EFS was similar for patients in cohort 5 treated with chemotherapy plus imatinib (88% ± 11%; 95% CI, 66% to 96%) or sibling donor BMT (57% ± 22%; 95% CI, 30.4% to 76.1%). There were no significant toxicities associated with adding imatinib to intensive chemotherapy. The higher imatinib dosing in cohort 5 appears to improve survival by having an impact on the outcome of children with a higher burden of minimal residual disease after induction. Conclusion Imatinib plus intensive chemotherapy improved 3-year EFS in children and adolescents with Ph+ ALL, with no appreciable increase in toxicity. BMT plus imatinib offered no advantage over BMT alone. Additional follow-up is required to determine the impact of this treatment on long-term EFS and determine whether chemotherapy plus imatinib can replace BMT. PMID:19805687

  1. Prognostic significance of ASXL1, JAK2V617F mutations and JAK2V617F allele burden in Philadelphia-negative myeloproliferative neoplasms

    PubMed Central

    Yonal-Hindilerden, Ipek; Daglar-Aday, Aynur; Akadam-Teker, Basak; Yilmaz, Ceylan; Nalcaci, Meliha; Yavuz, Akif Selim; Sargin, Deniz

    2015-01-01

    Background Despite insights into the genetic basis of Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPNs), a significant proportion of essential thrombocythemia (ET) and primary myelofibrosis (PMF) patients present with no known MPN disease alleles. There were no previous studies investigating the impact of ASXL1 mutations in Ph-negative MPNs in Turkey. In the current study, we investigated the prognostic significance of ASXL1 mutations in Turkish MPN patients. We also aimed to determine the prognostic significance of JAK2V617F allele burden and the relationship of JAK2V617F mutation with ASXL1 mutations in Ph-negative MPNs. Methods About 184 patients from a single center diagnosed with Ph-negative MPNs were screened for ASXL1, JAK2V617F mutations, and JAK2V617F allele burden: 107 ET and 77 PMF. Results A total of 29 ASXL1 mutations were detected in 24.7% of PMF and 8.4% of ET patients. ASXL1-mutated ET patients showed a trend toward an increase in the incidence of cerebrovascular events and higher total leukocyte counts. ASXL1-mutation in PMF was associated with older age and a higher prevalence of bleeding complications. In univariate analysis, overall survival (OS) was significantly reduced in ASXL1-mutated PMF patients. In multivariate analysis, Dynamic International Prognostic Scoring System-plus high-risk category and ASXL1 mutation status were independently associated with shorter survival in PMF. In PMF, mutational status and allele burden of JAK2V617F showed no difference in terms of OS and leukemia-free survival. Conclusion We conclude that ASXL1 mutations are molecular predictors of short OS in PMF. PMID:26082670

  2. Determination of prognosis of Philadelphia chromosome-negative myeloproliferative neoplasms with a simple clinical examination: Retrospective analysis of 71 patients in a single institution

    PubMed Central

    ITO, SHINICHI; TSUTSUMI, YUTAKA; OHIGASHI, HIROYUKI; SHIRATORI, SOUICHI; TESHIMA, TAKANORI

    2016-01-01

    Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocytosis (ET) and primary myelofibrosis (PMF), are clonal hematopoietic diseases. A single-institution retrospective analysis was performed, including 71 MPN patients diagnosed at the Hakodate Municipal Hospital between April, 2001 and April, 2014, and certain clinical characteristics were identified as effective prognostic factors. The patients were categorized by risk factor scoring based on age, number of abnormal blood cell lineages and splenomegaly at diagnosis, and the association between this categorization and prognosis was analyzed using a statistical procedure. The effect of Janus kinase 2 (JAK2) V617F mutation on prognosis was also investigated. The MPN patients were consolidated into three risk groups based on the margin of intergroup survival differences: i) Score 1–2 (n=23), ii) score 3 (n=24) and iii) score 4–5 (n=24). MPN patients with scores of 4 or 5 exhibited poorer overall survival (OS) compared with those with lower scores (P<0.001). In addition, there were significant differences in event-free survival (EFS) among scoring groups (P=0.0059). PV and ET had a better prognosis compared with PMF, although this analysis suggested that PV and ET patients with scores of 4 or 5 may have a poorer prognosis in terms of OS (P=0.0052) and EFS (P=0.022) and should be closely followed up. We observed no significant prognostic effect of the JAK2V167F mutation for OS (P=0.28) or EFS (P=0.17). Our results suggested that a simple scoring system based on age, blood cell counts and presence of splenomegaly at diagnosis may be used for the long-term prognosis of MPN patients. PMID:26870357

  3. PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells.

    PubMed

    Wu, Nan; Kurosu, Tetsuya; Oshikawa, Gaku; Nagao, Toshikage; Miura, Osamu

    2013-02-01

    PECAM-1 (CD31) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing surface glycoprotein expressed on various hematopoietic cells as well as on endothelial cells. PECAM-1 has been shown to play roles in regulation of adhesion, migration and apoptosis. The BCR/ABL fusion tyrosine kinase is expressed in chronic myeloid leukemia and Philadelphia-positive (Ph+) acute lymphoblastic leukemia cells, and its inhibition by the clinically used tyrosine kinase inhibitors imatinib or dasatinib induces apoptosis of these cells. In the present study, we demonstrate that PECAM-1 is tyrosine phospho-rylated in its ITIM motifs in various BCR/ABL-expressing cells including primary leukemia cells. Studies using imatinib and dasatinib as well as transient expression experiments in 293T cells revealed that PECAM-1 was phosphorylated directly by BCR/ABL, which was enhanced by the imatinib-resistant E255K and T315I mutations, or partly by the Src family tyrosine kinases, including Lyn, which were activated dependently or independently on BCR/ABL. We also demonstrate by using a substrate trapping mutant of SHP2 that tyrosine phosphorylated PECAM-1 binds SHP2 and is a major substrate for this tyrosine phosphatase in BCR/ABL-expressing cells. Overexpression of PECAM-1 in BCR/ABL-expressing cells, including K562 human leukemia cells, enhanced cell adhesion and partially inhibited imatinib-induced apoptosis involving mitochondria depolarization and caspase-3 cleavage, at least partly, in an ITIM-independent manner. These data suggest that PECAM-1 may play a role in regulation of apoptosis as well as adhesion of BCR/ABL-expressing cells to modulate their imatinib sensitivity and would be a possible candidate for therapeutic target in Ph+ leukemias. PMID:23233201

  4. Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH).

    PubMed

    Appelmann, Iris; Kreher, Stephan; Parmentier, Stefani; Wolf, Hans-Heinrich; Bisping, Guido; Kirschner, Martin; Bergmann, Frauke; Schilling, Kristina; Brümmendorf, Tim H; Petrides, Petro E; Tiede, Andreas; Matzdorff, Axel; Griesshammer, Martin; Riess, Hanno; Koschmieder, Steffen

    2016-04-01

    Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression to myelofibrosis and acute leukemia. Major bleeding represents a common and important complication in MPN, and the incidence of such bleeding events will become even more relevant in the future due to the increasing disease prevalence and survival of MPN patients. This review discusses the causes, differential diagnoses, prevention, and management of bleeding episodes in patients with MPN, aiming at defining updated standards of care in these often challenging situations.

  5. Classroom implementation of the practices learned in the Master of Chemistry Education program by the School District of Philadelphia's high school chemistry teachers

    NASA Astrophysics Data System (ADS)

    Jayaraman, Uma Devi

    This dissertation reports the results of an exploratory case study utilizing quantitative and qualitative methodologies intended to ascertain the extent and differences of implementation of research-based instructional practices, learned in an intensive 26-month professional development, in their urban classrooms. Both the extent and differences in the implementation of practices were investigated in relation to the lesson design and implementation, content, and classroom culture aspects of research-based practices. Additionally, this research includes the concerns of the teachers regarding the factors that helped or hindered the implementation of research-based practices in their classrooms. Six graduates of the Master of Chemistry Education Program who were teaching a chemistry course in a high school in the School District of Philadelphia at the time of the study (2006-8), were the case. The teachers completed a concerns questionnaire with closed and open-ended items, and rated their perceptions of the extent of implementation of the practices in their urban classrooms. Additionally, the teachers were observed and rated by the researcher using a reform-teaching observation protocol and were interviewed individually. Also, the teachers submitted their lesson plans for the days they were observed. Data from these sources were analyzed to arrive at the findings for this study. The research findings suggest that the group of teachers in the study implemented the research-based practices in their classrooms to a low extent when compared to the recommended practices inherent to the MCE Program. The extents of implementation of the practices differed widely among the teachers, from being absent to being implemented at a high level, with inconsistent levels of implementation from various data sources. Further, the teachers expressed the depth of knowledge (gained in the MCE Program), formal laboratory exercises and reports, administrative support, self

  6. A study of the attitudes and academic achievement in biology of females in a single-sex school vs. a coeducational school in the Philadelphia Archdiocesan secondary schools

    NASA Astrophysics Data System (ADS)

    Proach, John Ann

    2000-11-01

    There is proof that the educational system has conveyed unrealistic role expectations and has neglected to address the changing needs of girls. Children form attitudes about themselves and others based on the communications they get over time from parents, other adults, peers, and a variety of societal influences, including school. This study focused on two groups of tenth-grade high school, female, biology students in the Archdiocese of Philadelphia. The purpose was to compare attitude in science and academic achievement of females in a single-sex vs. a coeducational school. Data collection included three attitudinal surveys: Women in Science, Science Attitude Scale, and Perceptions of Science and Scientists, also the National Association of Biology Teachers/National Science Teachers High School Biology Examination Version B. administered as a pretest and posttest to measure academic achievement. These instruments were used to determine if the differences between attitudes and perceptions toward science and achievement in science were alike for females in a single-sex school and a coeducational school. The study also tested to see if females in a single-sex school would attain greater academic achievement in biology than girls in a coeducational school. The Chi-square statistic was used to analyze data in the three attitudinal surveys. The NABT/NSTA High School Biology Examination determined the students' initial and final competency levels in general biology. The mean science achievement of each of the two groups was tested for statistical significance using the t-test. In the two schools the t-test statistic showed significant difference between the pretest and a slight statistical difference on the posttest; the preferred analysis was an ANCOVA used to compare the posttest scores using the pretest as a covariate. The data implies that attitudes and perceptions are basically the same in both environments with minor differences. Results of these analyses suggest

  7. Anti-leukemic potency of piggyBac-mediated CD19-specific T cells against refractory Philadelphia chromosome–positive acute lymphoblastic leukemia

    PubMed Central

    Saito, Shoji; Nakazawa, Yozo; Sueki, Akane; Matsuda, Kazuyuki; Tanaka, Miyuki; Yanagisawa, Ryu; Maeda, Yasuhiro; Sato, Yuko; Okabe, Seiichi; Inukai, Takeshi; Sugita, Kanji; Wilson, Matthew H.; Rooney, Cliona M.; Koike, Kenichi

    2016-01-01

    Background aims To develop a treatment option for Philadelphia chromosome—positive acute lymphoblastic leukemia (Ph+ALL) resistant to tyrosine kinase inhibitors (TKIs), we evaluated the anti-leukemic activity of T cells non-virally engineered to express a CD19-specific chimeric antigen receptor (CAR). Methods A CD19.CAR gene was delivered into mononuclear cells from 10 mL of blood of healthy donors through the use of piggyBac-transposons and the 4-D Nucleofector System. Nucleofected cells were stimulated with CD3/CD28 antibodies, magnetically selected for the CD19.CAR, and cultured in interleukin-15–containing serum-free medium with autologous feeder cells for 21 days. To evaluate their cytotoxic potency, we co-cultured CAR T cells with seven Ph+ALL cell lines including three TKI-resistant (T315I–mutated) lines at an effector-to-target ratio of 1:5 or lower without cytokines. Results We obtained ~ 1.3 × 108 CART cells (CD4+, 25.4%; CD8+, 71.3%), co-expressing CD45RA and CCR7 up to ~80%. After 7-day co-culture, CAR T cells eradicated all tumor cells at the 1:5 and 1:10 ratios and substantially reduced tumor cell numbers at the 1:50 ratio. Kinetic analysis revealed up to 37-fold proliferation of CART cells during a 20-day culture period in the presence of tumor cells. On exposure to tumor cells, CAR T cells transiently and reproducibly upregulated the expression of transgene as well as tumor necrosis factor–related apoptosis-inducing ligand and interleukin-2. Conclusions We generated a clinically relevant number of CAR T cells from 10 mL of blood through the use of piggyBac-transposons, a 4D-Nulcleofector, and serum/xeno/tumor cell/virus-free culture system. CAR T cells exhibited marked cytotoxicity against Ph+ALL regardless of T315I mutation. PiggyBac-mediated CD19-specific T-cell therapy may provide an effective, inexpensive and safe option for drug-resistant Ph+ALL. PMID:25108652

  8. New Philadelphia, Illinois, Study Act

    THOMAS, 112th Congress

    Sen. Kirk, Mark Steven [R-IL

    2011-11-17

    11/17/2011 Read twice and referred to the Committee on Energy and Natural Resources. (text of measure as introduced: CR S7711-7712) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  9. New Philadelphia, Illinois, Study Act

    THOMAS, 113th Congress

    Rep. Schock, Aaron [R-IL-18

    2013-02-28

    04/29/2014 Received in the Senate and Read twice and referred to the Committee on Energy and Natural Resources. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  10. The Stephen H. Long Expedition (1819?1820), Titian R. Peale?s field illustrations, and the lost holotypes of the North American shrews Sorex brevicaudus Say and Sorex parvus Say (Mammalia: Soricidae) from the Philadelphia Museum

    USGS Publications Warehouse

    Woodman, N.

    2009-01-01

    While encamped for the winter of 1819?1820 at Engineer Cantonment along the Missouri River in present-day eastern Nebraska, members of Major Stephen Harriman Long?s Expedition to the Rocky Mountains collected a number of animals that were previously unknown. Among the mammals were two soricids that were subsequently described by Thomas Say as Sorex brevicaudus (Northern Short-tailed Shrew, Blarina brevicauda) and Sorex parvus (Least Shrew, Cryptotis parvus). The holotypes of these species were deposited and placed on public exhibit in the Philadelphia Museum, the predominant North American systematic collection of the early nineteenth century. Like most private museums of that era, the Philadelphia Museum eventually went out of business, and its collections were dispersed and, for the most part, lost. Fortunately, Titian R. Peale made a detailed field sketch of the two specimens soon after their capture and subsequently executed a watercolor based on that sketch. In addition, an engraving of the holotypes was published in the decade following the discovery of the two species. Illustrations of holotypes are taxonomically useful when they depict diagnostic characters of species. They take on added taxonomic significance in the absence of the holotypes. In the cases of Sorex brevicaudus and Sorex parvus, pictures provide strong confirmation of the taxonomic identities of these two species, as well as recording the early history of the specimens.

  11. EDITORIAL: Adaptive and active materials: Selected papers from the ASME 2010 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 10) (Philadelphia, PA, USA, 28 September-1 October 2010) Adaptive and active materials: Selected papers from the ASME 2010 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 10) (Philadelphia, PA, USA, 28 September-1 October 2010)

    NASA Astrophysics Data System (ADS)

    Brei, Diann

    2011-09-01

    The third annual meeting of the AMSE/AIAA Smart Materials, Adaptive Structures and Intelligent Systems Conference (SMASIS) took place in the heart of historic Philadelphia's cultural district, and included a pioneer banquet in the National Constitutional Center. The applications emphasis of the 2010 conference was reflected in keynote talks by Dr Alan Taub, vice president of General Motors global research and development, 'Smart materials in the automotive industry'; Dr Charles R Farrar, engineering institute leader at Los Alamos National Laboratory, 'Future directions for structural health monitoring of civil engineering infrastructure'; and Professor Christopher S Lynch of the University of California Los Angeles, 'Ferroelectric materials and their applications'. The SMASIS conference was divided into six technical symposia each of which included basic research, applied technological design and development, and industrial and governmental integrated system and application demonstrations. The six symposia were: SYMP 1 Multifunctional Materials; SYMP 2 Active Materials, Mechanics and Behavior; SYMP 3 Modeling, Simulation and Control; SYMP 4 Enabling Technologies and Integrated System Design; SYMP 5 Structural Health Monitoring/NDE; and SYMP 6 Bio-inspired Smart Materials and Structures. In addition, the conference introduced a new student and young professional development symposium. Authors of papers in the materials areas (symposia 1, 2 and 6) were invited to write a full journal article on their presentation topic for publication in this special issue of Smart Materials and Structures. This set of papers demonstrates the exceptional quality and originality of the conference presentations. We are appreciative of their efforts in producing this collection of highly relevant articles on smart materials.

  12. Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH).

    PubMed

    Appelmann, Iris; Kreher, Stephan; Parmentier, Stefani; Wolf, Hans-Heinrich; Bisping, Guido; Kirschner, Martin; Bergmann, Frauke; Schilling, Kristina; Brümmendorf, Tim H; Petrides, Petro E; Tiede, Andreas; Matzdorff, Axel; Griesshammer, Martin; Riess, Hanno; Koschmieder, Steffen

    2016-04-01

    Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression to myelofibrosis and acute leukemia. Major bleeding represents a common and important complication in MPN, and the incidence of such bleeding events will become even more relevant in the future due to the increasing disease prevalence and survival of MPN patients. This review discusses the causes, differential diagnoses, prevention, and management of bleeding episodes in patients with MPN, aiming at defining updated standards of care in these often challenging situations. PMID:26916570

  13. Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

    PubMed Central

    Trino, Stefania; Iacobucci, Ilaria; Erriquez, Daniela; Laurenzana, Ilaria; De Luca, Luciana; Ferrari, Anna; Luserna Di Rorà, Andrea Ghelli; Papayannidis, Cristina; Derenzini, Enrico; Simonetti, Giorgia; Lonetti, Annalisa; Venturi, Claudia; Cattina, Federica; Ottaviani, Emanuela; Abbenante, Maria Chiara; Russo, Domenico; Perini, Giovanni; Musto, Pellegrino; Martinelli, Giovanni

    2016-01-01

    MDM2 is an important negative regulator of p53 tumor suppressor. In this study, we sought to investigate the preclinical activity of the MDM2 antagonist, Nutlin-3a, in Philadelphia positive (Ph+) and negative (Ph−) leukemic cell line models, and primary B-acute lymphoblastic leukemia (ALL) patient samples. We demonstrated that Nutlin-3a treatment reduced viability and induced p53-mediated apoptosis in ALL cells with wild-type p53 protein, in a time and dose-dependent manner, resulting in the increased expression of pro-apoptotic proteins and key regulators of cell cycle arrest. The dose-dependent reduction in cell viability was confirmed in primary blast cells from B-ALL patients, including Ph+ ALL resistant patients carrying the T315I BCR-ABL1 mutation. Our findings provide a strong rational for further clinical investigation of Nutlin-3a in Ph+ and Ph− ALL. PMID:26887044

  14. Long-term follow-up of the imatinib GRAAPH-2003 study in newly diagnosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL study.

    PubMed

    Tanguy-Schmidt, Aline; Rousselot, Philippe; Chalandon, Yves; Cayuela, Jean-Michel; Hayette, Sandrine; Vekemans, Marie-Christiane; Escoffre, Martine; Huguet, Françoise; Réa, Delphine; Delannoy, André; Cahn, Jean-Yves; Vernant, Jean-Paul; Ifrah, Norbert; Dombret, Hervé; Thomas, Xavier

    2013-01-01

    We report here the results of the GRAAPH-2003 trial with long-term follow-up in 45 patients with de novo Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Imatinib-based strategy improved the 4-year overall survival (OS) up to 52% versus 20% in the pre-imatinib LALA-94 trial (P = .0001). Despite the selection in patients who actually underwent transplantation, these results suggest that allogeneic or autologous stem cell transplants (SCTs) still have a place in overcoming the poor prognosis of Ph+ ALL in the era of imatinib therapy. OS was 50% after allogeneic SCT (24 patients), 33% in patients without a transplantation (9 patients), and 80% after autologous SCT (10 patients without allogeneic donor or >55 years, including 7 patients in complete molecular response). PMID:22960387

  15. Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients.

    PubMed

    Trino, Stefania; Iacobucci, Ilaria; Erriquez, Daniela; Laurenzana, Ilaria; De Luca, Luciana; Ferrari, Anna; Di Rorà, Andrea Ghelli Luserna; Papayannidis, Cristina; Derenzini, Enrico; Simonetti, Giorgia; Lonetti, Annalisa; Venturi, Claudia; Cattina, Federica; Ottaviani, Emanuela; Abbenante, Maria Chiara; Russo, Domenico; Perini, Giovanni; Musto, Pellegrino; Martinelli, Giovanni

    2016-03-15

    MDM2 is an important negative regulator of p53 tumor suppressor. In this study, we sought to investigate the preclinical activity of the MDM2 antagonist, Nutlin-3a, in Philadelphia positive (Ph+) and negative (Ph-) leukemic cell line models, and primary B-acute lymphoblastic leukemia (ALL) patient samples. We demonstrated that Nutlin-3a treatment reduced viability and induced p53-mediated apoptosis in ALL cells with wild-type p53 protein, in a time and dose-dependent manner, resulting in the increased expression of pro-apoptotic proteins and key regulators of cell cycle arrest. The dose-dependent reduction in cell viability was confirmed in primary blast cells from B-ALL patients, including Ph+ ALL resistant patients carrying the T315I BCR-ABL1 mutation. Our findings provide a strong rational for further clinical investigation of Nutlin-3a in Ph+ and Ph- ALL. PMID:26887044

  16. Youth Employment Act of 1979, Part 3; Hearings before the Subcommittee on Employment Opportunities of the Committee on Education and Labor, House of Representatives, Ninety-Sixth Congress, First Session on H.R. 4465 and H.R. 4534 (New York, New York on September 17; Philadelphia, Pennsylvania, October 20, 1979).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    This is a report of hearings held in New York City on September 17, 1979, and in Philadelphia on October 20, 1979, on two federal youth employment bills: H.R. 4465 and H.R. 4534. H.R. 4465 proposes to combine immediate work and training and training opportunities with long term changes in the institutions and programs which serve young people.…

  17. Possible correlation of b3-a2-type bcr-abl messenger RNA defined by semiquantitative RT-PCR to platelet and megakaryocyte counts in Philadelphia-positive chronic myelogenous leukemia.

    PubMed

    Inokuchi, K; Futaki, M; Dan, K; Nomura, T

    1994-04-01

    Thirty-five patients with Philadelphia chromosome (Ph1)-positive chronic myelogenous leukemia (CML) were classified on the basis of the fusion pattern of bcr-abl mRNA determined by the reverse-transcriptase-polymerase chain reaction (RT-PCR) method. Semiquantitative assay of the bcr exon 2/abl exon 2 fused mRNA (b2-a2) and bcr exon 3/abl exon 2 fused mRNA (b3-a2) resulted in 21 patients showing b3-a2 type mRNA, seven showing b2-a2 type and seven showing coexpression. Quantification of the autoradiographic signals of amplified products was estimated using an MCID image analysis system. The relative intensity was defined as the ratio of bcr-abl signal to that of beta-actin. The relationship between the semiquantified bcr-abl mRNA and the platelet/megakaryocyte counts was analyzed. A possible correlation was found between the semiquantified b3-a2 type mRNA and the platelet (p < .05, N = 28) and megakaryocyte (p < .05, N = 13) counts of these patients. This finding suggests the possibility that b3-a2 mRNA may affect the thrombopoietic activity in Ph1-positive CML in a dose-response manner. PMID:7520786

  18. Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Separated into Two Subgroups Associated with Survival by BCR-ABL Fluorescence in situ Hybridization of Segmented Cell Nuclei: Report from a Single Institution.

    PubMed

    Kamoda, Yoshimasa; Izumi, Kiyotaka; Iioka, Futoshi; Akasaka, Takashi; Nakamura, Fumihiko; Kishimori, Chiyuki; Tsuda, Katsuyo; Fukutsuka, Katsuhiro; Okumura, Atsuko; Hayashida, Masahiko; Ohno, Hitoshi

    2016-01-01

    Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) may include the lymphoid blast crisis of chronic myeloid leukemia (CML-BC). We applied fluorescence in situ hybridization (FISH) of the BCR-ABL fusion gene to peripheral blood and/or bone marrow smears to determine whether the fusion was restricted to mononuclear cell nuclei or if segmented cell nuclei representing mature neutrophils also carried the fusion (Seg-FISH). Among 20 patients with Ph+ ALL without a prior diagnosis of CML, 9 were Seg-FISH+ and 11 were Seg-FISH-. Seg-FISH+ cases were characterized by a higher rate of p210-type BCR-ABL transcripts, higher white cell and blast counts, and a higher rate of myeloid and T-lymphoid antigen expression than Seg-FISH- cases, in addition to 'major route' cytogenetic abnormalities associated with CML-BC. Eighteen patients were treated with tyrosine kinase inhibitors (TKIs) either alone or in combination with multiagent chemotherapy, and 7 underwent allogeneic hematopoietic stem cell transplantation. Progression-free and overall survivals were greater in the Seg-FISH+ group than in the Seg-FISH- group. These results suggest that the Seg-FISH+ group represents lymphoid CML-BC that occurs de novo, while the Seg-FISH- represents Ph+ ALL in the strict sense, and the two groups are associated with survival when treated with TKIs or TKI-combined therapy. PMID:27537935

  19. Evidence-based guidelines for the use of tyrosine kinase inhibitors in adults with Philadelphia chromosome–positive or BCR-ABL–positive acute lymphoblastic leukemia: a Canadian consensus

    PubMed Central

    Couban, S.; Savoie, L.; Mourad, Y. Abou; Leber, B.; Minden, M.; Turner, R.; Palada, V.; Shehata, N.; Christofides, A.; Lachance, S.

    2014-01-01

    Adult Philadelphia chromosome–positive (Ph+) or BCR-ABL–positive (BCR-ABL+) acute lymphoblastic leukemia (all) is an acute leukemia previously associated with a high relapse rate, short disease-free survival, and poor overall survival. In adults, allogeneic hematopoietic cell transplant in first remission remains the only proven curative strategy for transplant-eligible patients. The introduction of tyrosine kinase inhibitors (tkis) in the treatment of patients with Ph+ or BCR-ABL+ all has significantly improved the depth and duration of complete remission, allowing more patients to proceed to transplantation. Although tkis are now considered a standard of care in this setting, few randomized trials have examined the optimal use of tkis in patients with Ph+ all. Questions of major importance remain, including the best way to administer these medications, the choice of tki to administer, and the schedule and the duration to use. We present the results of a systematic review of the literature with consensus recommendations based on the available evidence. PMID:24764712

  20. Pre-transplant achievement of negativity in minimal residual disease and French-American-British L1 morphology predict superior outcome after allogeneic transplant for Philadelphia chromosome positive acute lymphoblastic leukemia: an analysis of Southeast Asian patients.

    PubMed

    Ma, Liyuan; Hao, Siguo; Diong, Colin; Goh, Yeow-Tee; Gopalakrishnan, Sathish; Ho, Aloysius; Hwang, William; Koh, Liang-Piu; Koh, Mickey; Lim, Zi-Yi; Loh, Yvonne; Poon, Michelle; Tan, Lip-Kun; Tan, Patrick; Linn, Yeh-Ching

    2015-05-01

    To better understand predictive factors and improve the clinical outcome of allogeneic transplant for patients with Philadelphia positive acute lymphoblastic leukemia, we analyzed 67 Southeast Asian patients transplanted in our institutions. Multivariate analysis showed that disease status before transplant, year of transplant and, interestingly, French-American-British (FAB) subtype had a significant impact on overall survival (OS) and non-relapse mortality. Patients who were minimal residual disease (MRD) negative at transplant had a 3-year OS of 73% compared to those who were MRD positive (45%) and refractory (0%). The 3-year cumulative incidence of relapse was 18% and 36% for the MRD negative and positive groups, respectively. FAB L1 subtype had a significantly superior 3-year OS of 63% vs. 29% for L2 subtype. Pre-transplant use of a tyrosine kinase inhibitor significantly improved outcomes in univariate but not multivariate analysis, as it served to induce more patients into MRD negativity, which was the factor that directly improved transplant outcome.

  1. A Multiplex Snapback Primer System for the Enrichment and Detection of JAK2 V617F and MPL W515L/K Mutations in Philadelphia-Negative Myeloproliferative Neoplasms

    PubMed Central

    Zhang, Yunqing; Zhang, Xinju; Xu, Xiao; Kang, Zhihua; Li, Shibao; Zhang, Chen; Su, Bing

    2014-01-01

    A multiplex snapback primer system was developed for the simultaneous detection of JAK2 V617F and MPL W515L/K mutations in Philadelphia chromosome- (Ph-) negative myeloproliferative neoplasms (MPNs). The multiplex system comprises two snapback versus limiting primer sets for JAK2 and MPL mutation enrichment and detection, respectively. Linear-After exponential (LATE) PCR strategy was employed for the primer design to maximize the amplification efficiency of the system. Low ionic strength buffer and rapid PCR protocol allowed for selective amplification of the mutant alleles. Amplification products were analyzed by melting curve analysis for mutation identification. The multiplex system archived 0.1% mutation load sensitivity and <5% coefficient of variation inter-/intra-assay reproducibility. 120 clinical samples were tested by the multiplex snapback primer assay, and verified with amplification refractory system (ARMS), quantitative PCR (qPCR) and Sanger sequencing method. The multiplex system, with a favored versatility, provided the molecular diagnosis of Ph-negative MPNs with a suitable implement and simplified the genetic test process. PMID:24729973

  2. Establishment and characterization of A novel Philadelphia-chromosome positive chronic myeloid leukemia cell line, TCC-S, expressing P210 and P190 BCR/ABL transcripts but missing normal ABL gene.

    PubMed

    Van, Phan Nguyen Thanh; Xinh, Phan Thi; Kano, Yasuhiko; Tokunaga, Katsushi; Sato, Yuko

    2005-03-01

    A novel Philadelphia-chromosome positive (Ph+) cell line, TCC-S, has been established from a patient with Ph+ chronic myeloid leukemia (CML) in the blastic crisis. TCC-S cells were shown to express both P210 and P190 BCR/ABL transcripts by reverse transcriptase-polymerase chain reaction (PCR), although quantitative-PCR revealed that TCC-S cells mainly expressed P210 BCR/ABL transcript. Karyotype analysis revealed several triploid clones which constantly harbored two der(9)del(9) (p12)t(9;22) (q34;qll)s and two del(9) (q21)s. The der(9)del(9) (p12)t(9;22) (q34;q11) is rarely found in other CML cell lines. Moreover, to the best of our knowledge, del(9) (q21) resulting in missing of a restrict region including normal ABL gene has not been found among CML cell lines previously described. Thus, TCC-S cells with only BCR/ABL gene and no normal ABL gene may be a useful tool for functional study of ABL in Ph+ CML.

  3. Health care setting and severity, symptom burden, and complications in patients with Philadelphia-negative myeloproliferative neoplasms (MPN): a comparison between university hospitals, community hospitals, and office-based physicians.

    PubMed

    Kaifie, A; Isfort, S; Gattermann, N; Hollburg, W; Klausmann, M; Wolf, D; Maintz, C; Hänel, M; Goekkurt, E; Göthert, J R; Platzbecker, U; Geer, T; Parmentier, S; Jost, E; Serve, H; Ehninger, G; Berdel, W E; Brümmendorf, T H; Koschmieder, Steffen

    2016-09-01

    Philadelphia-negative myeloproliferative neoplasms (MPN) comprise a heterogeneous group of chronic hematological malignancies with significant variations in clinical characteristics. Due to the long survival and the feasibility of oral or subcutaneous therapy, these patients are frequently treated outside of larger academic centers. This analysis was performed to elucidate differences in MPN patients in three different health care settings: university hospitals (UH), community hospitals (CH), and office-based physicians (OBP). The MPN registry of the Study Alliance Leukemia is a non-interventional prospective study including adult patients with an MPN according to WHO criteria (2008). For statistical analysis, descriptive methods and tests for significant differences were used. Besides a different distribution of MPN subtypes between the settings, patients contributed by UH showed an impaired medical condition, a higher comorbidity burden, and more vascular complications. In the risk group analyses, the majority of polycythemia vera (PV) and essential thrombocythemia (ET) patients from UH were classified into the high-risk category due to previous vascular events, while for PV and ET patients in the CH and OBP settings, age was the major parameter for a high-risk categorization. Regarding MPN-directed therapy, PV patients from the UH setting were more likely to receive ruxolitinib within the framework of a clinical trial. In summary, the characteristics and management of patients differed significantly between the three health care settings with a higher burden of vascular events and comorbidities in patients contributed by UH. These differences need to be taken into account for further analyses and design of clinical trials. PMID:27334946

  4. Imatinib use immediately before stem cell transplantation in children with Philadelphia chromosome-positive acute lymphoblastic leukemia: Results from Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study Ph(+) ALL04.

    PubMed

    Manabe, Atsushi; Kawasaki, Hirohide; Shimada, Hiroyuki; Kato, Itaru; Kodama, Yuichi; Sato, Atsushi; Matsumoto, Kimikazu; Kato, Keisuke; Yabe, Hiromasa; Kudo, Kazuko; Kato, Motohiro; Saito, Tomohiro; Saito, Akiko M; Tsurusawa, Masahito; Horibe, Keizo

    2015-05-01

    Incorporation of imatinib into chemotherapeutic regimens has improved the prognosis of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL). We investigated a role of imatinib immediately before hematopoietic stem cell transplantation (HSCT). Children with Ph(+) ALL were enrolled on JPLSG Ph(+) ALL 04 Study within 1 week of initiation of treatment for ALL. Treatment regimen consisted of Induction phase, Consolidation phase, Reinduction phase, 2 weeks of imatinib monotherapy phase, and HSCT phase (Etoposide+CY+TBI conditioning). Minimal residual disease (MRD), the amount of BCR-ABL transcripts, was measured with the real-time PCR method. The study was registered in UMIN-CTR: UMIN ID C000000290. Forty-two patients were registered and 36 patients (86%) achieved complete remission (CR). Eight of 17 patients (47%) who had detectable MRD at the beginning of imatinib monotherapy phase showed disappearance or decrease in MRD after imatinib treatment. Consequently, 26 patients received HSCT in the first CR and all the patients had engraftment and no patients died because of complications of HSCT. The 4-year event-free survival rates and overall survival rates among all the 42 patients were 54.1 ± 7.8% and 78.1 ± 6.5%, respectively. Four of six patients who did achieve CR and three of six who relapsed before HSCT were salvaged with imatinib-containing chemotherapy and subsequently treated with HSCT. The survival rate was excellent in this study although all patients received HSCT. A longer use of imatinib concurrently with chemotherapy should eliminate HSCT in a subset of patients with a rapid clearance of the disease. PMID:25641907

  5. A rare case of a three way complex variant positive Philadelphia translocation involving chromosome (9;11;22)(q34;p15;q11) in chronic myeloid leukemia: A case report

    PubMed Central

    Asif, Muhammad; Hussain, Abrar; Rasool, Mahmood

    2016-01-01

    The t(9;22)(q34;q11) translocation is present in 90–95% of patients with chronic myeloid leukemia (CML). Variant complex translocations have been observed in 5–8% of CML patients, in which a third chromosome other than (9;22) is involved. Imatinib mesylate is the first line breakpoint cluster region-Abelson gene (BCR/ABL)-targeted oral therapy for CML, and may produce a complete response in 70–80% of CML patients in the chronic phase. In the present study, a bone marrow sample was used for conventional cytogenetic analysis, and the fluorescence in situ hybridization (FISH) test was used for BCR/ABL gene detection. A hematological analysis was also performed to determine the white blood cell (WBC) count, red blood cell count, hemoglobin levels, packed and mean cell volumes, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and platelet values of the patient. The hematological analysis of the patient indicated the increased WBC of 186.5×103 cells/µl, and decreased hemoglobin levels of 11.1 g/dl. The FISH test revealed that 67% cells demonstrated BCR/ABL gene translocation. The patient was treated with 400 mg imatinib mesylate daily, and was monitored at various intervals over a 6-month period. The present study reports the rare case of a patient that demonstrates a three-way Philadelphia chromosome-positive translocation involving 46XY,t(9;11;22)(q34;p15;q11)[10], alongside CML in the chronic phase. The translocation was analyzed using cytogenetic and FISH tests.

  6. A rare case of a three way complex variant positive Philadelphia translocation involving chromosome (9;11;22)(q34;p15;q11) in chronic myeloid leukemia: A case report

    PubMed Central

    Asif, Muhammad; Hussain, Abrar; Rasool, Mahmood

    2016-01-01

    The t(9;22)(q34;q11) translocation is present in 90–95% of patients with chronic myeloid leukemia (CML). Variant complex translocations have been observed in 5–8% of CML patients, in which a third chromosome other than (9;22) is involved. Imatinib mesylate is the first line breakpoint cluster region-Abelson gene (BCR/ABL)-targeted oral therapy for CML, and may produce a complete response in 70–80% of CML patients in the chronic phase. In the present study, a bone marrow sample was used for conventional cytogenetic analysis, and the fluorescence in situ hybridization (FISH) test was used for BCR/ABL gene detection. A hematological analysis was also performed to determine the white blood cell (WBC) count, red blood cell count, hemoglobin levels, packed and mean cell volumes, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and platelet values of the patient. The hematological analysis of the patient indicated the increased WBC of 186.5×103 cells/µl, and decreased hemoglobin levels of 11.1 g/dl. The FISH test revealed that 67% cells demonstrated BCR/ABL gene translocation. The patient was treated with 400 mg imatinib mesylate daily, and was monitored at various intervals over a 6-month period. The present study reports the rare case of a patient that demonstrates a three-way Philadelphia chromosome-positive translocation involving 46XY,t(9;11;22)(q34;p15;q11)[10], alongside CML in the chronic phase. The translocation was analyzed using cytogenetic and FISH tests. PMID:27602125

  7. First Report of a Phase II Prospective Study of Combination of Hyper-CVAD with Ponatinib in Frontline Therapy of Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

    PubMed Central

    Jabbour, Elias; Kantarjian, Hagop; Ravandi, Farhad; Thomas, Deborah; Huang, Xuelin; Faderl, Stefan; Pemmaraju, Naveen; Daver, Naval; Garcia-Manero, Guillermo; Sasaki, Koji; Cortes, Jorge; Garris, Rebecca; Yin, C. Cameron; Khoury, Joseph D.; Jorgensen, Jeffrey; Estrov, Zeev; Bohannan, Zachary; Konopleva, Marina; Kadia, Tapan; Jain, Nitin; DiNardo, Courtney; Wierda, William; Jeanis, Vicky; O’Brien, Susan

    2016-01-01

    Background The combination of chemotherapy with a tyrosine kinase inhibitor (TKI) is effective in the treatment of Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Ponatinib is a more potent BCR-ABL1 inhibitor and selectively suppresses the resistant T315I clones. We examined the efficacy and safety of combining chemotherapy with ponatinib for patients with Ph+ ALL in this ongoing Phase II prospective trial. Methods Adult patients with newly diagnosed Ph+ ALL and good performance and organ status received 8 cycles of hyper-CVAD alternating with high dose methotrexate/cytarabine every 21 days. Ponatinib was given at 45 mg daily for the first 14 days of cycle 1 then continuously for the subsequent cycles. Patients in complete remission (CR) received maintenance with ponatinib 45 mg daily with vincristine/prednisone monthly for 2 years followed by ponatinib indefinitely. The primary endpoint for this study was the improvement of median event-free survival from 24 to 36 months. The trial was registered on clinicaltrials.gov with the identifier NCT01424982. Results Thirty-seven patients with a median age of 51 years were treated. The overall complete cytogenetic response, major molecular response, and complete molecular response rates were 32/32 (100%), 35/37 (95%), and 29/37 (78%), respectively. By multiparameter flow cytometry, 35 patients (95%) had no detectable minimal residual disease after a median of 3 weeks of therapy. Grade ≥ 3 toxicity included infections during induction (20 patients), increased liver functional tests (14 patients), thrombotic events (3 patients), myocardial infarction (3 patients), hypertension (6 patients), skin rash (8 patients), and pancreatitis (6 patients). Two potentially related deaths from myocardial infarction were observed. Nine patients underwent allogeneic stem cell transplantation. With a median follow up of 26 months, 29 patients (78%) remain alive and in CR. The 2-year event-free and overall survival rates are

  8. 34. Photographic copy of Hangar Doors (Ammann and Whitney and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. Photographic copy of Hangar Doors (Ammann and Whitney and The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviaiton, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  9. 33. Photographic copy of Main Roof Girder Details (Ammann and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Photographic copy of Main Roof Girder Details (Ammann and Whitney and The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviaiton. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  10. 28. Photographic copy of North, South, East Elevation (The Ballinger ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Photographic copy of North, South, East Elevation (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia. Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  11. 25. Photographic copy of First Floor Plan (The Ballinger Company, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Photographic copy of First Floor Plan (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  12. 30. Photographic copy of Wall Sections and Details (The Ballinger ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. Photographic copy of Wall Sections and Details (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E. Philadelphia International Airport Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  13. 31. Photographic copy of Leanto Roof Framing Plan & Bent ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Photographic copy of Leanto Roof Framing Plan & Bent Details (Ammann and Whitney and The Balinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  14. 29. Photographic copy of West Elevation and Sections Through Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Photographic copy of West Elevation and Sections Through Building (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia. Division of Aviation. Terminal E. Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  15. 32. Photographic copy of Hangar Roof Framing Plan (Ammann and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Photographic copy of Hangar Roof Framing Plan (Ammann and Whitney and The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  16. 27. Photographic copy of Mexxanine Plan, Roof Plan and Details ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Photographic copy of Mexxanine Plan, Roof Plan and Details (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  17. 26. Photographic copy of Second Floor Plan (The Ballinger Company, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Photographic copy of Second Floor Plan (The Ballinger Company, April 12, 1955), In files of the City of Philadelphia. Division of Aviation, Terminal E. Philadelphia International Airport. Reprinted with permission of Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  18. 35. Photographic copy of Hangar Door Canopy Details (Ammann and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. Photographic copy of Hangar Door Canopy Details (Ammann and Whitney and The Ballinger Company. April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E. Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  19. 8. DETAIL OF NORTHEAST ELEVATION SHOWING NEON TWA SIGN AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. DETAIL OF NORTHEAST ELEVATION SHOWING NEON TWA SIGN AND ROOF MASTS. LOOKING SOUTHWEST. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  20. A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy.

    PubMed

    Borthakur, Gautam; Dombret, Herve; Schafhausen, Philippe; Brummendorf, Tim Henrik; Boissel, Nicolas; Jabbour, Elias; Mariani, Mariangela; Capolongo, Laura; Carpinelli, Patrizia; Davite, Cristina; Kantarjian, Hagop; Cortes, Jorge E

    2015-07-01

    Danusertib is a pan-aurora kinase inhibitor with potent activity against Abl kinase including the gatekeeper T315I mutant. A phase 1 dose escalation study of danusertib was conducted in patients with accelerated or blastic phase chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Two dosing schedules were studied: schedule A, in which danusertib was given by 3-hour intravenous infusion daily for 7 consecutive days (days 1-7) in a 14-day cycle, and schedule B, in which the danusertib was given by 3-hour intravenous infusion daily for 14 consecutive days (days 1-14) in a 21-day cycle. A total of 37 patients were treated, 29 with schedule A and eight with schedule B. The recommended phase 2 dose for schedule A was 180 mg/m(2). Enrollment to schedule B was stopped early because of logistical problems with the frequency of infusions. Febrile neutropenia and mucositis were dose-limiting toxicities in schedule A. Four patients with T315I ABL kinase mutation, all treated with schedule A, responded. Danusertib has an acceptable toxicity profile and is active in patients with Bcr-Abl-associated advanced hematologic malignancies. This study was registered with the European Clinical Trails Data Base (EudraCT number 2007-004070-18). PMID:25887498

  1. Use of tyrosine kinase inhibitors to prevent relapse after allogeneic hematopoietic stem cell transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: A position statement of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

    PubMed

    Giebel, Sebastian; Czyz, Anna; Ottmann, Oliver; Baron, Frederic; Brissot, Eolia; Ciceri, Fabio; Cornelissen, Jan J; Esteve, Jordi; Gorin, Norbert-Claude; Savani, Bipin; Schmid, Christoph; Mohty, Mohamad; Nagler, Arnon

    2016-10-01

    Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a standard of care for patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) to first-line therapy has improved overall outcomes; however, a significant proportion of patients still relapse after alloHSCT. Posttransplant TKI maintenance was demonstrated to reduce the risk of relapse in a large retrospective study and, therefore, should be considered a valuable option. This consensus paper, written on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, presents an overview of clinical studies on the use of TKIs after alloHSCT and proposes practical recommendations regarding the choice of TKI, treatment timing, and dosage. It is hoped that these recommendations will become the state of art in this field and, more importantly, lead to a reduction of Ph-positive ALL relapse after alloHSCT. Cancer 2016;122:2941-2951. © 2016 American Cancer Society. PMID:27309127

  2. A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy

    PubMed Central

    Borthakur, Gautam; Dombret, Herve; Schafhausen, Philippe; Brummendorf, Tim Henrik; Boissel, Nicolas; Jabbour, Elias; Mariani, Mariangela; Capolongo, Laura; Carpinelli, Patrizia; Davite, Cristina; Kantarjian, Hagop; Cortes, Jorge E.

    2015-01-01

    Danusertib is a pan-aurora kinase inhibitor with potent activity against Abl kinase including the gatekeeper T315I mutant. A phase 1 dose escalation study of danusertib was conducted in patients with accelerated or blastic phase chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Two dosing schedules were studied: schedule A, in which danusertib was given by 3-hour intravenous infusion daily for 7 consecutive days (days 1–7) in a 14-day cycle, and schedule B, in which the danusertib was given by 3-hour intravenous infusion daily for 14 consecutive days (days 1–14) in a 21-day cycle. A total of 37 patients were treated, 29 with schedule A and eight with schedule B. The recommended phase 2 dose for schedule A was 180 mg/m2. Enrollment to schedule B was stopped early because of logistical problems with the frequency of infusions. Febrile neutropenia and mucositis were dose-limiting toxicities in schedule A. Four patients with T315I ABL kinase mutation, all treated with schedule A, responded. Danusertib has an acceptable toxicity profile and is active in patients with Bcr-Abl-associated advanced hematologic malignancies. This study was registered with the European Clinical Trails Data Base (EudraCT number 2007-004070-18). PMID:25887498

  3. Intermediate dose of imatinib in combination with chemotherapy followed by allogeneic stem cell transplantation improves early outcome in paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL): results of the Spanish Cooperative Group SHOP studies ALL-94, ALL-99 and ALL-2005.

    PubMed

    Rives, Susana; Estella, Jesús; Gómez, Pedro; López-Duarte, Mónica; de Miguel, Purificación García; Verdeguer, Amparo; Moreno, Maria José; Vivanco, José Luis; Couselo, José Miguel; Fernández-Delgado, Rafael; Maldonado, Marisol; Tasso, María; López-Ibor, Blanca; Lendínez, Francisco; López-Almaraz, Ricardo; Uriz, Javier; Melo, Montserrat; Fernández-Teijeiro, Ana; Rodríguez, Isidoro; Badell, Isabel

    2011-09-01

    Philadelphia-chromosome acute lymphoblastic leukaemia (Ph+ ALL) is a subgroup of ALL with very high risk of treatment failure. We report here the results of the Sociedad Española de Hematología y Oncología Pediátricas (SEHOP/SHOP) in paediatric Ph+ ALL treated with intermediate-dose imatinib concurrent with intensive chemotherapy. The toxicities and outcome of these patients were compared with historical controls not receiving imatinib. Patients with Ph+ ALL aged 1-18years were enrolled in three consecutive ALL/SHOP trials (SHOP-94/SHOP-99/SHOP-2005). In the SHOP-2005 trial, imatinib (260mg/m(2) per day) was given on day-15 of induction. Allogeneic haematopoietic stem-cell transplantation (HSCT) from a matched related or unrelated donor was scheduled in first complete remission (CR1). Forty-three patients were evaluable (22 boys, median age 6·8years, range, 1·2-15). Sixteen received imatinib whereas 27 received similar chemotherapy without imatinib. Seventeen of 27 and 15 of 16 patients in the non-imatinib and imatinib cohort, respectively, underwent HSCT in CR1. With a median follow-up of 109 and 39months for the non-imatinib and imatinib cohorts, the 3-year event-free survival (EFS) was 29·6% and 78·7%, respectively (P=0·01). These results show that, compared to historical controls, intermediate dose of imatinib given concomitantly with chemotherapy and followed by allogeneic HSCT markedly improved early EFS in paediatric Ph+ ALL.

  4. Airport noise

    NASA Technical Reports Server (NTRS)

    Pendley, R. E.

    1982-01-01

    The problem of airport noise at several airports and air bases is detailed. Community reactions to the noise, steps taken to reduce jet engine noise, and the effect of airport use restrictions and curfews on air transportation are discussed. The adverse effect of changes in allowable operational noise on airport safety and altenative means for reducing noise pollution are considered. Community-airport relations and public relations are discussed.

  5. 24. Photographic copy of photograph of mezzanine, interior of hangar, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Photographic copy of photograph of mezzanine, interior of hangar, taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  6. 17. Photographic copy of photograph of north elevation taken on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photographic copy of photograph of north elevation taken on March 22, 1957, photographer unknown. Original photograph property of the City of Philadelphia. Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  7. 18. Photographic copy of photograph of south and east elevations ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Photographic copy of photograph of south and east elevations taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  8. 21. Photographic copy of photograph of interior of hangar looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Photographic copy of photograph of interior of hangar looking east taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  9. 23. Photographic copy of photograph of interior of hangar looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photographic copy of photograph of interior of hangar looking south taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  10. 19. Photographic copy of photograph of portion of east elevation ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Photographic copy of photograph of portion of east elevation taken on March 22, 1957 showing door beam and ladder to building roof. Photographer unknown. Original photograph property of the City of Philadelphia. Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  11. 22. Photographic copy of photograph of interior of hangar looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Photographic copy of photograph of interior of hangar looking west taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  12. 20. Photographic copy of photograph of roof suspender system taken ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photographic copy of photograph of roof suspender system taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  13. Reverse Engineering Course at Philadelphia University in Jordan

    ERIC Educational Resources Information Center

    Younis, M. Bani; Tutunji, T.

    2012-01-01

    Reverse engineering (RE) is the process of testing and analysing a system or a device in order to identify, understand and document its functionality. RE is an efficient tool in industrial benchmarking where competitors' products are dissected and evaluated for performance and costs. RE can play an important role in the re-configuration and…

  14. Act Up Philadelphia: HIV/AIDS adult standard of care.

    PubMed

    1998-01-01

    The minimum standards of care for persons with HIV are detailed. Patients should be cared for by HIV-experienced physicians. Viral load monitoring should be a part of the treatment program and aggressive therapy should be considered unless current treatments provide stable viral loads. Current Johns Hopkins guidelines say that doctors should, for instance, never use monotherapy, should not add a protease inhibitor to a failing regimen, and should use full-dose treatments. Tables describe the tests and treatments appropriate for a variety of CD4 levels.

  15. Directory of Ethnic Resources of Philadelphia and Delaware Valley.

    ERIC Educational Resources Information Center

    Jaipaul

    Among the ethnic groups dealt with by this comprehensive directory are Albanians, Armenians, blacks, Chinese, Danes, Filipinos, Germans, Greeks, Hungarians, Irish, Italians, Japanese, Jews, Koreans, Latvians, Lebanese, Lithuanians, Norwegians, Poles, Portuguese, Puerto Ricans, Russians, Scots, Serbs, Swiss, Turks, Ukranians, Vietnamese, and…

  16. Benjamin Franklin, Philadelphia's favorite son, was a membrane biophysicist.

    PubMed

    Wang, Da-Neng; Stieglitz, Heather; Marden, Jennifer; Tamm, Lukas K

    2013-01-22

    Benjamin Franklin, mostly known for his participation in writing The Declaration of Independence and work on electricity, was also one of the first scientists to seek to understand the properties of oil monolayers on water surfaces. During one of his many voyages across the Atlantic Ocean, Franklin observed that oil had a calming effect on waves when poured into rough ocean waters. Though at first taking a backseat to many of his other scientific and political endeavors, Franklin went on to experiment with oil, spreading monomolecular films on various bodies of water, and ultimately devised a concept of particle repulsion that is indirectly related to the hydrophobic effect. His early observations inspired others to measure the dimensions of oil monolayers, which eventually led to the formulation of the contemporary lipid bilayer model of the cell membrane.

  17. Teacher Networks in Philadelphia: Landscape, Engagement, and Value

    ERIC Educational Resources Information Center

    Schiff, Daniel; Herzog, Liza; Farley-Ripple, Elizabeth; Iannuccilli, Lauren Thum

    2015-01-01

    Teacher collaboration has become an increasingly important lever for school improvement efforts. This is especially true in high need urban districts, which struggle with capacity building in the face of significant teacher turnover, major shifts in curriculum and instruction, and scarce resources. This paper employs a mixed methods approach to…

  18. 77 FR 47792 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may submit a request... Guard there have been no requests requiring openings since the acquisition in June 1999. Since the 1999 CSX acquisition up to the present day, the Conrail Bridge is an active and heavily used CSX...

  19. Characterization of the Philadelphia chromosome by gene mapping.

    PubMed

    Geurts van Kessel, A H; ten Brinke, H; Boere, W A; den Boer, W C; de Groot, P G; Hagemeijer, A; Meera Khan, P; Pearson, P L

    1981-01-01

    Chinese hamster X human and mouse X human somatic cell hybrid lines were obtained using circulating leucocytes from six chronic myeloid leukemia patients. All six patients carried the Ph1 translocation, t(9q+;22q-), characteristic of chronic myeloid leukemia, in their dividing immature granulocytes. Analysis of independent hybrid clones yielded the following results: 1. The chromosome 9 markers, soluble aconitase and adenylate kinase-1, segregated with the 9q+ derivative. The latter marker has previously been localized to 9q34. 2. The chromosome 22 markers, mitochondrial aconitase, N-acetyl-alpha-D-galactosaminidase, and arylsulfatase-A, also segregated with the 9q+ derivative. Mitochondrial aconitase has recently been assigned to 22q11 leads to 22q13. No evidence was obtained either for reciprocity of the translocation or for variations in breakpoints in different patients. The results reported in this paper provisionally assign the gene for mitochondrial aconitase to a region distal to the breakpoint in 22q11. PMID:6944169

  20. Watershed Central: Dynamic Collaboration for Improving Watershed Management (Philadelphia)

    EPA Science Inventory

    The Watershed Central web and wiki pages will be presented and demonstrated real-time as part of the overview of Web 2.0 collaboration tools for watershed management. The presentation portion will discuss how EPA worked with watershed practitioners and within the Agency to deter...

  1. Case Study: Philadelphia. Needle-Moving Community Collaboratives

    ERIC Educational Resources Information Center

    Seldon, Willa; Jolin, Michele; Schmitz, Paul

    2012-01-01

    Communities face powerful challenges that require powerful solutions: a high-school dropout epidemic, youth unemployment, teen pregnancy. In an era of limited resources, those solutions must help communities to achieve more with less. A new kind of community collaborative--an approach that aspires to significant community-wide progress by…

  2. Obesity and Other Predictors of Absenteeism in Philadelphia School Children

    ERIC Educational Resources Information Center

    Rappaport, Elizabeth B.; Daskalakis, Constantine; Andrel, Jocelyn

    2011-01-01

    Background: Limited data indicate that obese children are absent from school more than their normal-weight peers. We analyzed administrative data from a large urban school district to investigate the association of obesity and student sociodemographic characteristics with absenteeism. Methods: We analyzed 291,040 records, representing 165,056…

  3. Airport Screening

    MedlinePlus

    ... 2011 Photo courtesy of Dan Paluska/Flickr Denver Airport Security Screening Introduction With air travel regaining popularity and increased secu- rity measures, airport security screening has become an area of interest for ...

  4. Philadelphia's Teacher Hiring and School Assignment Practices. Comparisons with Other Districts. A Report from Learning from Philadelphia's School Reform

    ERIC Educational Resources Information Center

    Useem, Elizabeth; Farley, Elizabeth

    2004-01-01

    Many big-city school systems nationwide are modernizing, expediting, and decentralizing the ways in which teachers are recruited, hired, and placed in schools, as well as offering a range of new incentives to attract and retain teachers. Districts are rapidly adopting new employment processing technologies, notably automated applicant-tracking…

  5. Whiffing the Airport Interview

    ERIC Educational Resources Information Center

    Williamson, David

    2008-01-01

    An airport interview is an initial interview for a senior administrative position conducted at an airport hotel not too far from the campus in question. Meeting at an airport enables a search committee to interview a large number of candidates in a short period of time with a degree of confidentiality. At the conclusion of the airport interviews,…

  6. Airport technology international 1993

    NASA Astrophysics Data System (ADS)

    Papagiorcopulo, George

    The present survey of developments in airport technologies and their management discusses airport extensions and upgradings, airport developments in China, polluter penalization, airport effects on environments, European ground-handling methods, ATC in Europe, EC duty-free sales at airports, and the privatization of airport security. Also discussed are airport advertising, new alternatives in air-cargo handling, ATC training, taxi-guidance systems, and the reduction of fuel consumption and emissions on the ground. (No individual items are abstracted in this volume)

  7. NASA New Virtual Airport

    NASA Technical Reports Server (NTRS)

    1995-01-01

    NASA's Virtual Airport Tower is located at the Ames Research Center, Moffett Field, California. The Virtual Airport Tower's two-story structure is a full-scale, highly sophisticated simulation facility that will emulate Level 5 air traffic control towers and the busiest airports. It provides the platform to conduct in-depth human factors studies with quantifiable results using actual air traffic controllers, airline dispatchers and airport managers.

  8. Aircraft assembly shop plant no. 2, view looking east ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aircraft assembly shop plant no. 2, view looking east - northeast. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Aircraft Assembly Shop Plant, League Island, Philadelphia, Philadelphia County, PA

  9. Management engineering (building no. 4), looking west along Porter Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Management engineering (building no. 4), looking west along Porter Avenue. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  10. Methodology for Analysis, Modeling and Simulation of Airport Gate-waiting Delays

    NASA Astrophysics Data System (ADS)

    Wang, Jianfeng

    This dissertation presents methodologies to estimate gate-waiting delays from historical data, to identify gate-waiting-delay functional causes in major U.S. airports, and to evaluate the impact of gate operation disruptions and mitigation strategies on gate-waiting delay. Airport gates are a resource of congestion in the air transportation system. When an arriving flight cannot pull into its gate, the delay it experiences is called gate-waiting delay. Some possible reasons for gate-waiting delay are: the gate is occupied, gate staff or equipment is unavailable, the weather prevents the use of the gate (e.g. lightning), or the airline has a preferred gate assignment. Gate-waiting delays potentially stay with the aircraft throughout the day (unless they are absorbed), adding costs to passengers and the airlines. As the volume of flights increases, ensuring that airport gates do not become a choke point of the system is critical. The first part of the dissertation presents a methodology for estimating gate-waiting delays based on historical, publicly available sources. Analysis of gate-waiting delays at major U.S. airports in the summer of 2007 identifies the following. (i) Gate-waiting delay is not a significant problem on majority of days; however, the worst delay days (e.g. 4% of the days at LGA) are extreme outliers. (ii) The Atlanta International Airport (ATL), the John F. Kennedy International Airport (JFK), the Dallas/Fort Worth International Airport (DFW) and the Philadelphia International Airport (PHL) experience the highest gate-waiting delays among major U.S. airports. (iii) There is a significant gate-waiting-delay difference between airlines due to a disproportional gate allocation. (iv) Gate-waiting delay is sensitive to time of a day and schedule peaks. According to basic principles of queueing theory, gate-waiting delay can be attributed to over-scheduling, higher-than-scheduled arrival rate, longer-than-scheduled gate-occupancy time, and reduced gate

  11. Volcanic hazards to airports

    USGS Publications Warehouse

    Guffanti, M.; Mayberry, G.C.; Casadevall, T.J.; Wunderman, R.

    2009-01-01

    Volcanic activity has caused significant hazards to numerous airports worldwide, with local to far-ranging effects on travelers and commerce. Analysis of a new compilation of incidents of airports impacted by volcanic activity from 1944 through 2006 reveals that, at a minimum, 101 airports in 28 countries were affected on 171 occasions by eruptions at 46 volcanoes. Since 1980, five airports per year on average have been affected by volcanic activity, which indicates that volcanic hazards to airports are not rare on a worldwide basis. The main hazard to airports is ashfall, with accumulations of only a few millimeters sufficient to force temporary closures of some airports. A substantial portion of incidents has been caused by ash in airspace in the vicinity of airports, without accumulation of ash on the ground. On a few occasions, airports have been impacted by hazards other than ash (pyroclastic flow, lava flow, gas emission, and phreatic explosion). Several airports have been affected repeatedly by volcanic hazards. Four airports have been affected the most often and likely will continue to be among the most vulnerable owing to continued nearby volcanic activity: Fontanarossa International Airport in Catania, Italy; Ted Stevens Anchorage International Airport in Alaska, USA; Mariscal Sucre International Airport in Quito, Ecuador; and Tokua Airport in Kokopo, Papua New Guinea. The USA has the most airports affected by volcanic activity (17) on the most occasions (33) and hosts the second highest number of volcanoes that have caused the disruptions (5, after Indonesia with 7). One-fifth of the affected airports are within 30 km of the source volcanoes, approximately half are located within 150 km of the source volcanoes, and about three-quarters are within 300 km; nearly one-fifth are located more than 500 km away from the source volcanoes. The volcanoes that have caused the most impacts are Soufriere Hills on the island of Montserrat in the British West Indies

  12. Learning to Learn. Newspaper in Education Supplement, The Philadelphia Inquirer, Monday, January 12, 1987.

    ERIC Educational Resources Information Center

    Cummings, Alysa

    Aimed at classroom teachers interested in teaching learning skills to their elementary and secondary students, this guide offers an alternative to teaching "facts" that may rapidly become outdated. The guide is based on Dr. Leslie Hart's Proster Theory, which proposes that the brain requires large amounts of input to function; that after searching…

  13. Health hazard evaluation report No. HETA 82-272-1276, Boeing Vertol Company, Philadelphia, Pennsylvania

    SciTech Connect

    Chrostek, W.; Liss, G.M.; Moss, G.

    1983-03-01

    To evaluate employee health complaints, including anxiety, nausea, eye strain, and headache thought possibly related to working under high pressure sodium vapor (HPSV) lamps and working with storage boxes dipped in sulfur, air samples were collected in May and July 1982 for exposures to sulfates, sulfites, and sulfur dioxide. A calibrated photometer was used to measure illumination in units of lux. Self-administered questionnaires were completed. To further assess possible color distortion, investigators administered the Farnsworth-Munsell 100-Hue Test to 15 employees in Building 3-25. Environmental sampling found non-detectable levels of sulfite. The illumination levels in some parts of the building were far less than optimal. Although no serious adverse health effects were noted, symptoms related to the eyes and minor abnormalities of color discrimination, possibly related to HPSV lamps and exposure to sulfur containers, were detected. Recommendations to improve the lighting situation are presented.

  14. 33 CFR 165.T05-0511 - Safety Zone, Delaware River; Philadelphia, PA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... regulations governing safety zones in 33 CFR 165.33. (1) All persons or vessels wishing to transit through the... of the Commodore Barry Bridge within a 350 yard radius of the fireworks barge located at latitude...

  15. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Eastern Paralyzed Veterans Association, Inc., James J. Peters, Terrance Moakley, and Denise Figueroa... between Eastern Paralyzed Veterans Association of Pennsylvania, Inc., and James J. Peters,...

  16. Proceedings of the Symposium on Minimum Competency Testing (Philadelphia, Pennsylvania, October 24-25, 1979).

    ERIC Educational Resources Information Center

    Mid-Atlantic Teacher Corps Network, Philadelphia, PA.

    The conference's keynote address is presented by Bernard C. Watson. Papers include: Vantage from the State Department of Education, by Robert G. Scanlon (Pennsylvania); Minimum Competency: As the Public Sees the Question, by Jacqueline Grennan Wexler; Minimum Competency Testing (MCT): A Tripartite Response from the Profession, by W. James Popham;…

  17. Preparation of Urban High School Leaders in Philadelphia through Multiorganizational Partnerships

    ERIC Educational Resources Information Center

    Kaimal, Girija; Barber, Margaret; Schulman, Marcia; Reed, Pete

    2012-01-01

    Partnerships between universities and school districts are increasingly being identified as a means to overcome the difficulties of preparing the next generation of urban high school principals. This article examines the development of such a multiorganizational partnership with a large urban school district, two universities, and a national…

  18. 77 FR 16854 - John Heinz National Wildlife Refuge at Tinicum, Delaware and Philadelphia Counties, PA; Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... for John Heinz NWR. We started this process through a notice in the Federal Register (75 FR 25285; May... observation, photography, and fishing. Background The CCP Process The National Wildlife Refuge System... for hunting, fishing, wildlife observation and photography, and environmental education...

  19. 78 FR 39601 - Safety Zone, Sugar House Casino Fireworks Display, Delaware River; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Sugar House Casino Fireworks Display... out zone that covers part of the Delaware River. Sugar House Casino has contracted with Pyrotecnico... Sugar House Casino Fireworks Display will pose significant risks to the public. The purpose of the...

  20. PHILADELPHIA AIR TOXICS STUDY: EVALUATION OF RISK MANAGEMENT OPTIONS USING MIRA

    EPA Science Inventory

    Evaluation of risk management options usually takes place within single programs at the U.S. EPA. This can produce inadvertent tradeoffs among important criteria by risk managers and other decision makers; resulting in decision surprises. This study is a demonstration of a diff...

  1. 77 FR 29869 - Amendment of Class E Airspace; New Philadelphia, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ..., area, creating additional controlled airspace at Harry Clever Field (77 FR 4705) Docket No. FAA-2011... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  2. 76 FR 25382 - Self-Regulatory Organizations; The Stock Clearing Corporation of Philadelphia; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... Parent Corporation, The NASDAQ OMX Group, Inc. April 27, 2011. Pursuant to Section 19(b)(1) of the... to amendments to the By-Laws of SCCP's parent corporation, The NASDAQ OMX Group, Inc. (``NASDAQ OMX...\\ Securities Exchange Act Release No. 34-64285 (April 8, 2011) 76 FR 21085 (April 14, 2011) (File No....

  3. 77 FR 44299 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... Proposed Rule Change With Respect to the Amendment of the By-Laws of Its Parent Corporation, The NASDAQ OMX... by-laws of its parent corporation, The NASDAQ OMX Group, Inc. (``NASDAQ OMX''). II....

  4. 78 FR 128 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... Proposed Rule Change With Respect to the Amendment of the By-Laws of Its Parent Corporation, The NASDAQ OMX... respect to the amendment of the by-laws of its parent corporation, The NASDAQ OMX Group, Inc. (``NASDAQ... (February 16, 2005), 70 FR 9688 (February 28, 2005) (SR-NYSE-2004-54); Securities Exchange Act Release...

  5. 77 FR 59962 - John Heinz National Wildlife Refuge at Tinicum, DE and Philadelphia Counties, PA; Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... known as Tinicum Marsh, to promote environmental education, and to afford visitors an opportunity to... environmental education and interpretation in an urban setting. We announce our decision and the availability of..., and environmental education and interpretation. We will review and update the CCP at least every...

  6. 76 FR 77038 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Order Approving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... 240.19b-4. \\3\\ Securities Exchange Act Release No. 34-65614 (October 24, 2011), 76 FR 67009 (October... therefore ordered, pursuant to Section 19(b)(2) \\8\\ of the Act, that the proposed rule change (File No....

  7. Health hazard evaluation report No. HETA 82-048-1132, Taylor Lock Company, Inc. , Philadelphia, Pennsylvania

    SciTech Connect

    Lewis, F.; Shoemaker, W.

    1982-06-01

    On November 30, 1981, NIOSH received a request for technical assistance to evaluate the potential health effects of a new radiofrequency heat sealing machine at the Taylor Lock Company. The heat sealer operators had complained of experiencing dizziness and headaches when working at the machine. On January 7, 1981, electric (E) and magnetic (H) field strength measurements of RF radiation were taken at the eyes, neck, chest, waist, gonads, knees, ankles, and hands of the operators of the RF heat sealer. NIOSH investigators concluded that there was a RF radiation hazard to the operator at the unloading end of the machine. Recommendations are made in the body of the full report to reduce the RF radiation exposure to the worker.

  8. Delta Pi Epsilon National Research Conference Proceedings (Philadelphia, Pennsylvania, November 10-12, 1994).

    ERIC Educational Resources Information Center

    Delta Pi Epsilon Society, Little Rock, AR.

    Selected papers are as follows: "Are Office Support Personnel Aware of the Ergonomical Issues Associated with Computer Keyboarding?" (Evans); "Background and Characteristics of Japanese Students Who Enroll in an American Two-Year Information Processing Program Taught in Japan" (Morgan, Wiggs); "Business Education's (BE) Role in North Carolina Tech…

  9. Secondary prevention of drug dependence through the transcendental meditation program in metropolitan Philadelphia.

    PubMed

    Monahan, R J

    1977-09-01

    Using mailed questionnaires, the Transcendental Meditation program was investigated as an approach to the secondary prevention of substance dependence. Significant differences were found between a random sample of meditators and matched control subjects in usage levels and percentage of users for almost all legal and illegal drugs. Meditators had used more prescribed psychoactive medications before learning meditation, but usage levels returned to normal soon after starting. Former users of alcohol, cigarettes, or illegal drugs achieved remarkable abstinence records. For most substances the amount of decrease was positively correlated with degree of participation in the program and the length of time meditating.

  10. Weatherization Innovation Pilot Program: Program Overview and Philadelphia Project Highlight (Fact Sheet)

    SciTech Connect

    Not Available

    2012-01-01

    Case Study with WIPP program overview, information regarding eligibility, and successes from Pennsylvania's Commission on Economic Opportunity (CEO) that demonstrate innovative approaches that maximize the benefit of the program. The Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) recently launched the Weatherization Innovation Pilot Program (WIPP) to accelerate innovations in whole-house weatherization and advance DOE's goal of increasing the energy efficiency and health and safety of homes of low-income families. Since 2010, WIPP has helped weatherization service providers as well as new and nontraditional partners leverage non-federal financial resources to supplement federal grants, saving taxpayer money. WIPP complements the Weatherization Assistance program (WAP), which operates nation-wide, in U.S. territories and in three Native American tribes. 16 grantees are implementing weatherization innovation projects using experimental approaches to find new and better ways to weatherize homes. They are using approaches such as: (1) Financial tools - by understanding a diverse range of financing mechanisms, grantees can maximize the impact of the federal grant dollars while providing high-quality work and benefits to eligible low-income clients; (2) Green and healthy homes - in addition to helping families reduce their energy costs, grantees can protect their health and safety. Two WIPP projects (Connecticut and Maryland) will augment standard weatherization services with a comprehensive green and healthy homes approach; (3) New technologies and techniques - following the model of continuous improvement in weatherization, WIPP grantees will continue to use new and better technologies and techniques to improve the quality of work; (4) Residential energy behavior change - Two grantees are rigorously testing home energy monitors (HEMs) that display energy used in kilowatt-hours, allowing residents to monitor and reduce their energy use, and another is examining best-practices for mobile home energy efficiency; (5) Workforce development and volunteers - with a goal of creating a self-sustaining weatherization model that does not require future federal investment, three grantees are adapting business models successful in other sectors of the home performance business to perform weatherization work. Youthbuild is training youth to perform home energy upgrades to eligible clients and Habitat for Humanity is developing a model for how to incorporate volunteer labor in home weatherization. These innovative approaches will improve key weatherization outcomes, such as: Increasing the total number of homes that are weatherized; Reducing the weatherization cost per home; Increasing the energy savings in each weatherized home; Increasing the number of weatherization jobs created and retained; and Reducing greenhouse gas emissions.

  11. Influence of maternal health literacy on child participation in social welfare programs: the Philadelphia experience.

    PubMed

    Pati, Susmita; Mohamad, Zeinab; Cnaan, Avital; Kavanagh, Jane; Shea, Judy A

    2010-09-01

    We examined the influence of maternal health literacy on child participation in social welfare programs. In this cohort, 20% of the mothers had inadequate or marginal health literacy. Initially, more than 50% of the families participated in Temporary Assistance for Needy Families (TANF), the Food Stamp Program, and Special Supplemental Nutrition Program for Women, Infants, and Children, whereas fewer than 15% received child care subsidies or public housing. In multivariate regression, TANF participation was more than twice as common among children whose mothers had adequate health literacy compared with children whose mothers had inadequate health literacy.

  12. Advances in therapy for Philadelphia-positive acute lymphoblastic leukaemia of childhood and adolescence.

    PubMed

    Bleckmann, Kirsten; Schrappe, Martin

    2016-03-01

    The presence of the BCR/ABL1 fusion gene in childhood acute lymphoblastic leukaemia (ALL) is a rare finding and has been an adverse prognostic factor associated with a high risk of therapeutic failure. The current key components of treatment are intensive polychemotherapy and a BCR/ABL1 kinase domain inhibitor. This treatment approach has been applied in a few clinical trials by paediatric leukaemia study groups. Thus, this subtype of ALL serves as the first model system for truly targeted treatment. The role of haematopoietic stem cell transplantation (HSCT) is increasingly called into question, at least in a favourable, though not yet clearly defined, subset of patients. Currently, the choice of the most effective tyrosine kinase inhibitor is not yet settled, in particular, in view of potential reduction of overall treatment intensity.

  13. An Evaluation of Health and Safety Hazards in Family Based Day Care Homes in Philadelphia

    ERIC Educational Resources Information Center

    Perez, Hernando; Haynes, Sonia; Michael, Karen; Burstyn, Igor; Jandhyala, Malica; Palermo, Peter

    2011-01-01

    In Pennsylvania, Family Day Care Homes (FDCH) are private residences used to care for up to six children in a 24 h period. These homes are often times the most affordable alternative to day care centers parents have in low-income communities. The aims of this study were to evaluate FDCH providers' knowledge of hazards and their understanding of…

  14. 78 FR 36716 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Philadelphia County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... stationary sources of NO X and VOC. On November 29, 2005 (70 FR 71612), EPA published an ozone implementation...: The proposed rule published on August 26, 2008 (73 FR 50270) is withdrawn as of July 19, 2013. Written... major group for reducing VOC and NO x emissions from stationary sources. Since the 1970's, EPA...

  15. Influence of Socioeconomic Status on College Retention in Metro North Philadelphia

    ERIC Educational Resources Information Center

    Tolliver, Armando

    2013-01-01

    The purpose of this mixed methods study was to explore salient nonacademic factors related to social, economic, and cultural aspects together with traditional academic factors that influenced college retention. The study design employed a mixed-methods sequential explanatory method design, collecting quantitative data for correlation and…

  16. 75 FR 74127 - Proposed Modification of the Philadelphia, PA Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Thursday, February 17, 2011, will be held at Wings Field Terminal Building, 1501 Narcissa Road, Blue Bell, PA 19422; (4) The meeting on Tuesday, February 22, 2011, will also be held at Wings Field Terminal..., Eastern Service Area, Air Traffic Organization, Federal Aviation Administration, P.O. Box 20636,...

  17. 75 FR 69730 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ... is in an inactive status: (1) SCCP Article IV Section 2(c) and (d): SCCP proposes to suspend the... least one of SCCP's directors must be a governor of the Exchange; (2) SCCP Article IV, Section 8: SCCP...) accompanied by a report prepared by an independent public accountant; furnishing unaudited quarterly...

  18. ACCE Study Tour to ISTE2011 (San Francisco, New York, Washington, Philadelphia)

    ERIC Educational Resources Information Center

    Gronn, Donna; Romeo, Geoff

    2011-01-01

    In June/July this year a group of 28 educators from across Australia travelled to the US on the 2011 ACCE ISTE Study Tour. The group comprised a very broad section of educators--primary, secondary and tertiary classroom teachers, ICT coordinators, managers, private consultants and regional office managers. The government, catholic and independent…

  19. 77 FR 4705 - Proposed Amendment of Class E Airspace; New Philadelphia, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... also submit comments through the Internet at http://www.regulations.gov . You may review the public... the factual basis supporting the views and suggestions presented are particularly helpful in... through the Internet at http://www.regulations.gov . Recently published rulemaking documents can also...

  20. Nivolumab and Dasatinib in Treating Patients With Relapsed or Refractory Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

    ClinicalTrials.gov

    2016-08-25

    B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Refractory Adult Acute Lymphoblastic Leukemia; Refractory Childhood Acute Lymphoblastic Leukemia

  1. Using a Mystery-Caller Approach to Examine Access to Prostate Cancer Care in Philadelphia

    PubMed Central

    Pollack, Craig Evan; Ross, Michelle E.; Armstrong, Katrina; Branas, Charles C.; Rhodes, Karin V.; Bekelman, Justin E.; Wentz, Alicia; Stillson, Christian; Radhakrishnan, Archana; Oyeniran, Enny; Grande, David

    2016-01-01

    Purpose Prior work suggests that access to health care may influence the diagnosis and treatment of prostate cancer. Mystery-caller methods have been used previously to measure access to care for health services such as primary care, where patients’ self-initiate requests for care. We used a mystery-caller survey for specialized prostate cancer care to assess dimensions of access to prostate cancer care. Materials and Methods We created an inventory of urology and radiation oncology practices in southeastern Pennsylvania. Using a ‘mystery caller’ approach, a research assistant posing as a medical office scheduler in a primary care office, attempted to make a new patient appointment on behalf of a referred patient. Linear regression was used to determine the association between time to next available appointment with practice and census tract characteristics. Results We successfully obtained information on new patient appointments from 198 practices out of the 223 in the region (88.8%). Radiation oncology practices were more likely to accept Medicaid compared to urology practices (91.3% vs 36.4%) and had shorter mean wait times for new patient appointments (9.0 vs 12.8 days). We did not observe significant differences in wait times according to census tract characteristics including neighborhood socioeconomic status and the proportion of male African American residents. Conclusions Mystery-caller methods that reflect real-world referral processes from primary care offices can be used to measure access to specialized cancer care. We observed significant differences in wait times and insurance acceptance between radiation oncology and urology practices. PMID:27723780

  2. Association of Lymphoid Malignancies and Philadelphia-Chromosome Negative Myeloproliferative Neoplasms: Clinical Characteristics, Therapy and Outcome

    PubMed Central

    Masarova, Lucia; Newberry, Kate J.; Pierce, Sherry A.; Estrov, Zeev; Cortes, Jorge E.; Kantarjian, Hagop M.; Verstovsek, Srdan

    2015-01-01

    The co-occurrence of myeloproliferative and lymphoproliferative neoplasms (MPN/LPN) has been reported, mostly in case reports. The aim of this study was to assess the characteristics and clinical course of the coexistent diseases. Among 9866 patients who presented to our institution from 1960 to 2014, 34 (0.3%) were diagnosed with MPN/LPN. LPN was diagnosed first in 16 patients, second in 15, and at the same time in 3. The time to secondary malignancy was longer when LPN was diagnosed first (119 vs 98 months). Myelofibrosis (41%), polycythemia vera (24%), and essential thrombocythemia (18%) were the most common MPNs, and non-Hodgkin lymphoma (50%) and chronic lymphocytic leukemia (32%) were the most common LPNs. Seventy-three percent of patients treated for MPN and 72% of those treated for LPN achieved a complete response. After a median follow-up from MPN diagnosis of 84 months, 16 patients are alive and 18 died (4 related to MPN and 2 LPN). Coexistent MPN/LPN is a rare event that does not appear to predict worse outcomes. Treatment choice is generally oriented towards controlling the prevalent disease; the other malignancy may influence treatment strategies in selected cases. PMID:26012362

  3. Mobile robots IV; Proceedings of the Meeting, Philadelphia, PA, Nov. 6, 7, 1989

    SciTech Connect

    Wolfe, W.J.; Chun, W.H.

    1990-01-01

    The present conference on mobile robot systems discusses high-speed machine perception based on passive sensing, wide-angle optical ranging, three-dimensional path planning for flying/crawling robots, navigation of autonomous mobile intelligence in an unstructured natural environment, mechanical models for the locomotion of a four-articulated-track robot, a rule-based command language for a semiautonomous Mars rover, and a computer model of the structured light vision system for a Mars rover. Also discussed are optical flow and three-dimensional information for navigation, feature-based reasoning trail detection, a symbolic neural-net production system for obstacle avoidance and navigation, intelligent path planning for robot navigation in an unknown environment, behaviors from a hierarchical control system, stereoscopic TV systems, the REACT language for autonomous robots, and a man-amplifying exoskeleton.

  4. MEETING IN PHILADELPHIA: NUTRIENT CONCENTRATIONS IN FLOWING WATERS OF THE SOUTH FORK BROAD RIVER, GEORGIA WATERSHED

    EPA Science Inventory

    The objective of this poster is by comparing nutrient and DOM concentrations in small and large streams, we hope to better understand: (1) watershed controls on stream nutrient and DOM concentrations; and (2) the variability of nutrient and DOM concentrations within a river netwo...

  5. 76 FR 77669 - Amendment of Class D and E Airspace; North Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ..., PA. (76 FR 49383). Interested parties were invited to participate in this rulemaking effort by... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  6. Designing School 2.0: A Study of Philadelphia's Science Leadership Academy

    ERIC Educational Resources Information Center

    Lehmann, Chris

    2007-01-01

    Sooner or later, every teacher and administrator fantasizes about starting a school of their own. Few, however, move from off-the-cuff theory to the practical steps required to open the school house doors to real students and teachers. Fewer still manage to start an urban high school of their own while only in their mid-30s, a school that manages…

  7. John Buchanan's Philadelphia Diploma Mill and the Rise of State Medical Boards.

    PubMed

    Johnson, David Alan

    2015-01-01

    The absence of medical licensing laws in most states during the years following the American Civil War made it possible for unscrupulous individuals to capitalize upon the weak governmental role in medical practice and educational charters. The practices of John Buchanan during much of his tenure at the Eclectic Medical College of Pennsylvania, in issuing thousands of dubiously earned diplomas, caused a national and international scandal. The traffic in diplomas became so flagrant that regulatory oversight of physicians and their practice, such as that conducted by the Illinois Board of Health led by Dr. John Rauch, developed rapidly across the United States. Though multiple factors prompted the rebirth of medical licensing laws, professional, educational, journalistic, and public concerns for bogus diplomas played an important role. PMID:25913462

  8. 78 FR 75598 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... changes. However, in recent years, corporate governance standards have evolved, and many stockholder... corporate governance. NASDAQ OMX believes that while it is important to protect against coercive takeover... about corporate governance. NASDAQ OMX believes that the proposed ``majority of outstanding...

  9. 75 FR 25010 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... directors (``Board''). Under Corporate Governance Guidelines adopted by the Board, however, any director in... purpose. \\7\\ NASDAQ OMX also amended its Corporate Governance Guidelines to reflect the majority vote... proposed making certain amendments to its By-Laws to make improvements in its governance. In...

  10. Educational Management Organizations as High Reliability Organizations: A Study of Victory's Philadelphia High School Reform Work

    ERIC Educational Resources Information Center

    Thomas, David E.

    2013-01-01

    This executive position paper proposes recommendations for designing reform models between public and private sectors dedicated to improving school reform work in low performing urban high schools. It reviews scholarly research about for-profit educational management organizations, high reliability organizations, American high school reform, and…

  11. ASSOCIATIONS BETWEEN TRACE ELEMENTAL COMPOSITION OF PM2.5 AND MORTALITY AND MORBIDITY IN PHILADELPHIA

    EPA Science Inventory

    A large number of studies have reported associations between particulate matter (PM) and mortality and morbidity. Since PM is a chemically non-specific index and a mixture of a variety of chemical components from multiple sources, it is possible that use of the total PM mass as ...

  12. Student Library Resource Requirements in Philadelphia. Annual Report, Phase IV, June 15, 1971 - June 30, 1972.

    ERIC Educational Resources Information Center

    Benford, John Q.

    Project operations in the 1971-72 year clearly demonstrated the effectiveness of interagency collaboration in the intensive work of planning, establishing, and operation of the Action Library Demonstration Center. The Action Library is designed to effect maximum impact on inner-city student library needs, attitudes, and skills. The year covered by…

  13. 77 FR 64953 - Foreign-Trade Zone 35-Philadelphia, PA; Application for Reorganization and Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... FR l453l, 4/8/1978) and expanded on August 21, 1980 (Board Order 162, 45 FR 58388, 9/3/1980), December 29, 1993 (Board Order 678, 59 FR 1372, 1/10/1994), September 25, 2001 (Board Order 1189, 66 FR 52742, 10/17/2001), and June 27, 2002 (Board Order 1236, 67 FR 45456, 7/9/2002). The current...

  14. 77 FR 3545 - Receipt of Noise Compatibility Program and Request for Review for Philadelphia International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... FR 44046 (July 27, 2010). The proposed noise compatibility program will be approved or disapproved on... existing non-compatible uses and prevent the introduction of additional non-compatible uses. The FAA has..., limited by law to a maximum of 180 days, will be completed on or before July 17, 2012. The FAA's...

  15. An Undergraduate Mechatronics Project Class at Philadelphia University, Jordan: Methodology and Experience

    ERIC Educational Resources Information Center

    Tutunji, T. A.; Saleem, A.; Rabbo, S. A.

    2009-01-01

    Mechatronics is a branch of engineering whose final product should involve mechanical movements controlled by smart electronics. The design and implementation of functional prototypes are an essential learning experience for the students in this field. In this paper, the guidelines for a successful mechatronics project class are presented,…

  16. 78 FR 17634 - Foreign-Trade Zone 35-Philadelphia, Pennsylvania; Application for Subzone; Teva Pharmaceuticals...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... Pharmaceuticals USA, Inc.; North Wales, Chalfont, Kutztown and Sellersville, Pennsylvania An application has been... of FTZ 35, requesting special-purpose subzone status for the facilities of Teva Pharmaceuticals...

  17. Children and Families First: An Evaluation of the Philadelphia Say Yes to Education Program

    ERIC Educational Resources Information Center

    Gold, Eva; Hartmann, Tracey; Lewis, Kristine

    2005-01-01

    Say Yes to Education is a scholarship guarantee program that pledges to young children and their families a fully paid, post-secondary education along with academic and social supports that follow children throughout their elementary and high school careers. Since its inception in 1987, the Say Yes to Education program has "adopted" cohorts of…

  18. System manual for the University of Pennsylvania retrofitted solar heated Philadelphia row home (SolaRow)

    SciTech Connect

    Zinnes, I.; Lior, N.

    1980-05-01

    The University of Pennsylvania SolaRow house, an urban row home retrofitted for comfort and domestic hot water heating, was extensively instrumented for performance monitoring and acquisition of weather and solar radiation data. This report describes the heating and instrumentation systems, provides the details for instrumentation, piping and valve identification, and specifies the operation and maintenance of the heating and data acquisition systems. The following are included: (1) system flow diagrams; (2) valve and cable identification tables; (3) wiring diagrams; and (4) start-up, normal operation, shut-down, maintenance and trouble-shooting procedures. It thus provides the necessary technical information to permit system operation and monitoring, overall system performance analysis and optimization, and acquisition of climatological data.

  19. A resolution encouraging the Navy to commission the USS Somerset (LPD-25) in Philadelphia, Pennsylvania.

    THOMAS, 113th Congress

    Sen. Toomey, Pat [R-PA

    2013-02-28

    02/28/2013 Referred to the Committee on Armed Services. (text of measure as introduced: CR S1030) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  20. Intelligent control and adaptive systems; Proceedings of the Meeting, Philadelphia, PA, Nov. 7, 8, 1989

    NASA Technical Reports Server (NTRS)

    Rodriguez, Guillermo (Editor)

    1990-01-01

    Various papers on intelligent control and adaptive systems are presented. Individual topics addressed include: control architecture for a Mars walking vehicle, representation for error detection and recovery in robot task plans, real-time operating system for robots, execution monitoring of a mobile robot system, statistical mechanics models for motion and force planning, global kinematics for manipulator planning and control, exploration of unknown mechanical assemblies through manipulation, low-level representations for robot vision, harmonic functions for robot path construction, simulation of dual behavior of an autonomous system. Also discussed are: control framework for hand-arm coordination, neural network approach to multivehicle navigation, electronic neural networks for global optimization, neural network for L1 norm linear regression, planning for assembly with robot hands, neural networks in dynamical systems, control design with iterative learning, improved fuzzy process control of spacecraft autonomous rendezvous using a genetic algorithm.

  1. SUMMERTIME AMBIENT FORMALDEHYDE IN FIVE U.S. METROPOLITAN AREAS: NASHVILLE, ATLANTA, HOUSTON, PHILADELPHIA, TAMPA

    EPA Science Inventory

    In this paper, we briefly review the atmospheric chemistry and previous intercomparison measurements for HCHO, with special reference to the diffusion scrubber-Hantzsch reaction based fluorescence instrument used in the field studies reported herein. Then we discuss summertime HC...

  2. Imatinib-induced thyroiditis in Philadelphia chromosome-positive chronic myeloid leukemia

    PubMed Central

    Singh, Surjit; Sharma, Pramod Kumar

    2016-01-01

    Here, we present a case of chronic myeloid leukemia for which imatinib therapy was initated. Triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone was normal, and thyroid microsomal autoantibodies (TMA) were positive and patient was diagnosed as thyroiditis treated with corticosteroids for 1½ months which lead to resolution. PMID:27756963

  3. Policy and poverty. Child and community health in Philadelphia, 1900 to 1930.

    PubMed

    Brosco, J P

    1995-12-01

    On a fall day in 1913, a man sat on a crowded wooden bench with a little boy on his lap. He waited all day, only to be told that the physician who would treat his son was not working in the public clinic that day. The next morning he learned that if he returned at 3 o'clock in the afternoon, he would stand a better chance of seeing the physician. Since the family home was a shack and even food was scarce, he could ill afford the loss of another day's pay. His son had infantile paralysis, though, and the father believed that the physician could help, so he kept trying. The boy died during the Christmas holidays. "Is it simply that there are not enough public clinics, enough doctors willing to help care for the people who come to them?" asked the social worker who told this story. "Or is there something wrong with the system?"

  4. Benchmark Airport Charges

    NASA Technical Reports Server (NTRS)

    de Wit, A.; Cohn, N.

    1999-01-01

    The Netherlands Directorate General of Civil Aviation (DGCA) commissioned Hague Consulting Group (HCG) to complete a benchmark study of airport charges at twenty eight airports in Europe and around the world, based on 1996 charges. This study followed previous DGCA research on the topic but included more airports in much more detail. The main purpose of this new benchmark study was to provide insight into the levels and types of airport charges worldwide and into recent changes in airport charge policy and structure. This paper describes the 1996 analysis. It is intended that this work be repeated every year in order to follow developing trends and provide the most up-to-date information possible.

  5. Integrated Airport Surface Operations

    NASA Technical Reports Server (NTRS)

    Koczo, S.

    1998-01-01

    The current air traffic environment in airport terminal areas experiences substantial delays when weather conditions deteriorate to Instrument Meteorological Conditions (IMC). Research activity at NASA has culminated in the development, flight test and demonstration of a prototype Low Visibility Landing and Surface Operations (LVLASO) system. A NASA led industry team and the FAA developed the system which integrated airport surface surveillance systems, aeronautical data links, DGPS navigation, automation systems, and controller and flight deck displays. The LVLASO system was demonstrated at the Hartsfield-Atlanta International Airport using a Boeing 757-200 aircraft during August, 1997. This report documents the contractors role in this testing particularly in the area of data link and DGPS navigation.

  6. Airport Remote Tower Sensor Systems

    NASA Technical Reports Server (NTRS)

    Papasin, Richard; Gawdiak, Yuri; Maluf, David A.; Leidich, Christopher; Tran, Peter B.

    2001-01-01

    Remote Tower Sensor Systems (RTSS) are proof-of-concept prototypes being developed by NASA/Ames Research Center (NASA/ARC) with collaboration with the FAA (Federal Aviation Administration) and NOAA (National Oceanic Atmospheric Administration). RTSS began with the deployment of an Airport Approach Zone Camera System that includes real-time weather observations at San Francisco International Airport. The goal of this research is to develop, deploy, and demonstrate remotely operated cameras and sensors at several major airport hubs and un-towered airports. RTSS can provide real-time weather observations of airport approach zone. RTSS will integrate and test airport sensor packages that will allow remote access to realtime airport conditions and aircraft status.

  7. Supersonics--Airport Noise

    NASA Technical Reports Server (NTRS)

    Bridges, James

    2007-01-01

    At this, the first year-end meeting of the Fundamental Aeronautics Program, an overview of the Airport Noise discipline of the Supersonics Project leads the presentation of technical plans and achievements in this area of the Project. The overview starts by defining the Technical Challenges targeted by Airport Noise efforts, and the Approaches planned to meet these challenges. These are fleshed out in Elements, namely Prediction, Diagnostics, and Engineering, and broken down into Tasks. The Tasks level is where individual researchers' work is defined and from whence the technical presentations to follow this presentation come. This overview also presents the Milestones accomplished to date and to be completed in the next year. Finally, the NASA Research Announcement cooperative agreement activities are covered and tied to the Tasks and Milestones.

  8. 14 CFR 221.52 - Airport to airport application, accessorial services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Airport to airport application, accessorial... Charges § 221.52 Airport to airport application, accessorial services. Tariffs shall specify whether or not the fares therein include services in addition to airport-to-airport transportation....

  9. 75 FR 39090 - Airport Privatization Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... procedures to be used in applications for exemption under the Airport Privatization Pilot Program (62 FR... Federal Aviation Administration Airport Privatization Pilot Program AGENCY: Federal Aviation... Gwinnett County Airport Briscoe Field (LZU), Lawrenceville, Georgia. SUMMARY: The Federal...

  10. 75 FR 68018 - Airport Privatization Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... procedures to be used in applications for exemption under Airport Privatization Pilot Program (62 FR 48693... Federal Aviation Administration Airport Privatization Pilot Program AGENCY: Federal Aviation... Airglades Airport (2IS), Clewiston, Florida. SUMMARY: The Federal Aviation Administration (FAA)...

  11. 125. SECTION OF BREAST WHEEL, 1843 Frederic Graff, Jr., Collection ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    125. SECTION OF BREAST WHEEL, 1843 Frederic Graff, Jr., Collection of Philadelphia Museum of Art - Fairmount Waterworks, East bank of Schuylkill River, Aquarium Drive, Philadelphia, Philadelphia County, PA

  12. Attic floor; view west showing roof structural system North ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Attic floor; view west showing roof structural system - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  13. WEST CORRIDOR (ORIGINALLY KNOWN AS LIBRARY OF CONGRESS CARD CATALOG) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST CORRIDOR (ORIGINALLY KNOWN AS LIBRARY OF CONGRESS CARD CATALOG) ON FIRST FLOOR, LOOKING EAST - Free Library of Philadelphia, Central Library, 1901 Vine Street, Philadelphia, Philadelphia County, PA

  14. 3. Photocopy of 1932 photograph showing another general view of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of 1932 photograph showing another general view of the mansion, looking northwest. Original photograph at the Philadelphia Museum of Art. - Strawberry Mansion, Philadelphia, Philadelphia County, PA

  15. GENERAL VIEW OF INTERIOR, MAIN READING ROOM, LOOKING SOUTHWEST AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW OF INTERIOR, MAIN READING ROOM, LOOKING SOUTHWEST AND SHOWING VIEW INTO REAR SECTION - Free Library of Philadelphia, Richmond Branch, 2987 Almond Street, Philadelphia, Philadelphia County, PA

  16. 11. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST. - Philadelphia & Reading Railroad, Schuylkill River Viaduct, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  17. 17. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST - Philadelphia & Reading Railroad, Schuylkill River Viaduct, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  18. 9. LOOKING NW FROM EAST BANK OF SCHUYLKILL RIVER. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. LOOKING NW FROM EAST BANK OF SCHUYLKILL RIVER. - Philadelphia & Reading Railroad, Schuylkill River Viaduct, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  19. 8. Photocopy of circa 1892 construction photograph, courtesy of Reading ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of circa 1892 construction photograph, courtesy of Reading Company Archives - Philadelphia & Reading Railroad, Terminal Station, 1115-1141 Market Street, Philadelphia, Philadelphia County, PA

  20. Airport Pricing Strategies

    NASA Technical Reports Server (NTRS)

    Pels, Eric; Verhoef, Erik T.

    2003-01-01

    Conventional economic wisdom suggests that congestion pricing would be an appropriate response to cope with the growing congestion levels currently experienced at many airports. Several characteristics of aviation markets, however, may make naive congestion prices equal to the value of marginal travel delays a non-optimal response. This paper has developed a model of airport pricing that captures a number of these features. The model in particular reflects that airlines typically have market power and are engaged in oligopolistic competition at different sub-markets; that part of external travel delays that aircraft impose are internal to an operator and hence should not be accounted for in congestion tolls. We presented an analytical treatment for a simple bi-nodal symmetric network, which through the use of 'hyper-networks' would be readily applicable to dynamic problems (in discrete time) such as peak - off-peak differences, and some numerical exercises for the same symmetric network, which was only designed to illustrate the possible comparative static impacts of tolling, in addition to marginal equilibrium conditions as could be derived for the general model specification. Some main conclusions are that second-best optimal tolls are typically lower than what would be suggested by congestion costs alone and may even be negative, and that the toll as derived by Brueckner (2002) may not lead to an increase in total welfare. While Brueckner (2002) has made clear that congestion tolls on airports may be smaller than expected when congestion costs among aircraft are internal for a firm, our analysis adds to this that a further downward adjustment may be in order due to market power. The presence of market power (which causes prices to exceed marginal costs) may cause the pure congestion toll to be suboptimal, because the resulting decrease in demand is too high (the pure congestion tall does not take into account the decrease in consumer surplus). The various

  1. 75 FR 54946 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... assurances if the airport sponsor meets certain standards for control of airport operations and development; self- sustaining and nondiscriminatory airport rates; and compatible land use. At present, there are 75... and powers necessary to control and operate the airport; to maintain the airport in a safe...

  2. 77 FR 4394 - Release of Airport Property: Orlando Executive Airport, Orlando, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Federal Aviation Administration Release of Airport Property: Orlando Executive Airport, Orlando, FL AGENCY... provides notice of intent to release certain airport properties 12.4 acres at the Orlando Executive Airport... restrictions of a Quitclaim Deed agreement, dated August 9, 1961, between the subject airport and the...

  3. 19 CFR 122.84 - Intermediate airport.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Intermediate airport. 122.84 Section 122.84... Intermediate airport. (a) Application. The provisions of this section apply at any U.S. airport to which an... aircraft arrives at the next airport, the aircraft commander or agent shall make entry by filing the:...

  4. 49 CFR 27.71 - Airport facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Access Act rules (49 CFR part 382) for carriers. (g) If an airport operator who receives Federal... 49 Transportation 1 2010-10-01 2010-10-01 false Airport facilities. 27.71 Section 27.71... Administration Programs: Airports, Railroads, and Highways § 27.71 Airport facilities. (a) This section...

  5. Airport Careers. Aviation Careers Series. Revised.

    ERIC Educational Resources Information Center

    Zaharevitz, Walter

    This booklet, one in a series on aviation careers, outlines the variety of careers available in airports. The first part of the booklet provides general information about careers at airports, while the main part of the booklet outlines the following nine job categories: airport director, assistant airport director, engineers, support personnel,…

  6. Auctioning Airport Slots?

    NASA Technical Reports Server (NTRS)

    Gruyer, Nicolas; Lenoir, Nathalie

    2003-01-01

    The current allocation of slots on congested European airports constitutes an obstacle to the effective liberalisation of air transportation undertaken in Europe. With a view to favouring effluent slot utilisation and competition, as is the goal of the Euopean commission, we propose to use a market mechanism, based on temporary" utilisation licences. In order to allocate those licences, we propose and describe an iterated combinatorial auction mechanism where a percentage of licences would be reallocated each season. A secondary market would also be set up in order to reallocate slots during a season. Since a combinatorial auction involve a complex optimisation procedure, we describe how it can be made to work in the case of auctions.

  7. Determinants of Overall and Progression-Free Survival of Nigerian Patients with Philadelphia-Positive Chronic Myeloid Leukemia

    PubMed Central

    Oyekunle, Anthony A.; Bolarinwa, Rahman A.; Oyelese, Adesola T.; Salawu, Lateef; Durosinmi, Muheez A.

    2015-01-01

    Objective. The tyrosine kinase inhibitors have markedly changed the disease course for patients with Ph+ and/or BCR-ABL1+ chronic myeloid leukemia (CML). This study was embarked upon to assess the long-term effects of imatinib therapy on survival in adult Nigerian patients with CML. Methods. All adult patients on imatinib (400–600 mg) seen from July 2003 to December 2010 were assessed. Male/female distribution was 171/101, with a median age of 38 (range, 20–75) years. Overall survival (OS) and progression-free survival (PFS) were determined using the Kaplan-Meier techniques. Results. Of all the 272 patients, 205 were in chronic phase, 54 in accelerated phase, and five in blastic phase, at commencement of imatinib. As at December 2010, 222 were alive. OS at 1 and 5 years was 94% and 63%, while PFS was 89% and 54%, respectively. Similarly, amongst the 205 patients in chronic phase, OS at 1 and 5 years was 97% and 68%, while PFS was 92% and 57%. Conclusion. Imatinib's place as first-line therapy in the treatment of CML has further been reinforced in our patients, with improved survival and reduced morbidity, comparable with outcomes in other populations. PMID:26435715

  8. Sexual Attitudes and Knowldge Among Black Inner-City Elementary School Students in Philadelphia: A Pilot Study.

    ERIC Educational Resources Information Center

    Farrell, Walter C., Jr.; And Others

    Teenage and/or adolescent pregnancy is on the increase in most American cities and age of first pregnancy within this group is declining rapidly. In this study, sexual attitudes and knowledge among black inner-city elementary school students is documented. The effectiveness of a six week sex education class designed to provide these students with…

  9. Proceedings of the Annual Meeting of the American Journalism Historians' Association (Philadelphia, Pennsylvania, October 3-5, 1991).

    ERIC Educational Resources Information Center

    American Journalism Historians' Association.

    The 24 papers in this collection discuss a variety of issues concerning the history of journalism in many countries. The papers are: "The East-Indian American Press" (Arthi Subramaniam); "The World's Oldest Magazine and Its Place in the Evolution of British Periodicals" (Sam G. Riley); "Donna Allen and the Women's Institute: A Feminist Perspective…

  10. A Snapshot of OST Programming in Philadelphia: An Evaluation of Six 21st Century Community Learning Center Grantees

    ERIC Educational Resources Information Center

    Hartmann, Tracey A.; Gao, Jian; Kumar, Anurag; Edmunds, Kimberly

    2013-01-01

    This report looks at the 21st Century Community Learning Center (CCLC) programs evaluated by Research for Action (RFA). It seeks to answer the following questions: (1) Who participated in the 21st CCLC programs and how frequently did they participate?; (2) What elements of program quality were in place to achieve the intended outcomes?; and (3)…

  11. The Nation's Report Card Mathematics 2011 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 4, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2011

    2011-01-01

    This one-page report presents overall results, achievement level percentages and average score results, scores at selected percentiles, average scores for district and large cities, results for student groups (school race, gender, and eligibility for National School Lunch Program) in 2011, and score gaps for student groups. In 2011, the average…

  12. The Nation's Report Card Mathematics 2011 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 8, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2011

    2011-01-01

    This one-page report presents overall results, achievement level percentages and average score results, scores at selected percentiles, average scores for district and large cities, results for student groups (school race, gender, and eligibility for National School Lunch Program) in 2011, and score gaps for student groups. In 2011, the average…

  13. The Nation's Report Card Reading 2011 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 8, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2011

    2011-01-01

    This one-page report presents overall results, achievement level percentages and average score results, scores at selected percentiles, average scores for district and large cities, results for student groups (school race, gender, and eligibility for National School Lunch Program) in 2011, and score gaps for student groups. In 2011, the average…

  14. The Nation's Report Card Reading 2011 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 4, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2011

    2011-01-01

    This one-page report presents overall results, achievement level percentages and average score results, scores at selected percentiles, average scores for district and large cities, results for student groups (school race, gender, and eligibility for National School Lunch Program) in 2011, and score gaps for student groups. In 2011, the average…

  15. Universities and Neoliberal Models of Urban Development: Using Ethnographic Fieldwork to Understand the "Death and Rebirth of North Central Philadelphia"

    ERIC Educational Resources Information Center

    Hyatt, Susan Brin

    2010-01-01

    As a political and economic philosophy, neoliberalism has been used to reshape schools and universities, making them far more responsive to the pressures of the market. The principles associated with neoliberalism have also extended to programmes for urban economic development, particularly with respect to the large-scale gentrification of…

  16. A Snapshot of OST Programs in Philadelphia: An Evaluation of Eleven 21st Century Community Learning Center Grantees

    ERIC Educational Resources Information Center

    Gao, Jian; Hallar, Brittan; Hartmann, Tracey A.

    2014-01-01

    This report examines the 21st Century Community Learning Center (CCLC) programs evaluated by Research for Action (RFA) and presents an aggregate analysis of key findings to inform broader discussions about OST programs. The report addresses the following questions: (1) Who participated in the 21st CCLC programs and how frequently did they…

  17. LINKING AIR TOXIC CONCENTRATIONS FROM CMAQ TO THE HAPEM5 EXPOSURE MODEL AT NEIGHORHOOD SCALES FOR THE PHILADELPHIA AREA

    EPA Science Inventory

    This paper provides a preliminary demonstration of the EPA neighborhood scale modeling paradigm for air toxics by linking concentration from the Community Multi-scale Air Quality (CMAQ) modeling system to the fifth version of the Hazardous Pollutant Exposure Model (HAPEM5). For ...

  18. 33 CFR 165.T05-0495 - Safety Zone, Sugar House Casino Fireworks Display, Delaware River; Philadelphia, PA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... general safety zone regulations found in 33 CFR 165.23 apply to the safety zone created by this temporary... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone, Sugar House Casino... Areas Fifth Coast Guard District § 165.T05-0495 Safety Zone, Sugar House Casino Fireworks...

  19. Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan

    PubMed Central

    Imamura, T; Kiyokawa, N; Kato, M; Imai, C; Okamoto, Y; Yano, M; Ohki, K; Yamashita, Y; Kodama, Y; Saito, A; Mori, M; Ishimaru, S; Deguchi, T; Hashii, Y; Shimomura, Y; Hori, T; Kato, K; Goto, H; Ogawa, C; Koh, K; Taki, T; Manabe, A; Sato, A; Kikuta, A; Adachi, S; Horibe, K; Ohara, A; Watanabe, A; Kawano, Y; Ishii, E; Shimada, H

    2016-01-01

    Recent studies revealed that a substantial proportion of patients with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase and cytokine receptors, such as ABL1, PDGFRB, JAK2 and CRLF2, which are targeted by tyrosine kinase inhibitors (TKIs). In the present study, transcriptome analysis or multiplex reverse transcriptase–PCR analysis of 373 BCP-ALL patients without recurrent genetic abnormalities identified 29 patients with kinase fusions. Clinically, male predominance (male/female: 22/7), older age at onset (mean age at onset: 8.8 years) and a high white blood cell count at diagnosis (mean: 94 200/μl) reflected the predominance of National Cancer Institute high-risk (NCI-HR) patients (NCI-standard risk/HR: 8/21). Genetic analysis identified three patients with ABL1 rearrangements, eight with PDGFRB rearrangements, two with JAK2 rearrangements, three with IgH-EPOR and one with NCOR1-LYN. Of the 14 patients with CRLF2 rearrangements, two harbored IgH-EPOR and PDGFRB rearrangements. IKZF1 deletion was present in 16 of the 22 patients. The 5-year event-free and overall survival rates were 48.6±9.7% and 73.5±8.6%, respectively. The outcome was not satisfactory without sophisticated minimal residual disease-based stratification. Furthermore, the efficacy of TKIs combined with conventional chemotherapy without allogeneic hematopoietic stem cell transplantation in this cohort should be determined. PMID:27176795

  20. American Physiological Society Fall Meeting, August 15-20, 1976, University of Pennsylvania, Philadelphia, Pennsylvania. Abstracts of Papers

    ERIC Educational Resources Information Center

    Physiologist, 1976

    1976-01-01

    Presented are abstracts of papers arranged in alphabetical order by first-named author. The proceedings of the American Physiological Society were held jointly with the American Society of Zoologists (ASZ) and the Biomedical Engineering Society (BMES). (EB)

  1. Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan.

    PubMed

    Imamura, T; Kiyokawa, N; Kato, M; Imai, C; Okamoto, Y; Yano, M; Ohki, K; Yamashita, Y; Kodama, Y; Saito, A; Mori, M; Ishimaru, S; Deguchi, T; Hashii, Y; Shimomura, Y; Hori, T; Kato, K; Goto, H; Ogawa, C; Koh, K; Taki, T; Manabe, A; Sato, A; Kikuta, A; Adachi, S; Horibe, K; Ohara, A; Watanabe, A; Kawano, Y; Ishii, E; Shimada, H

    2016-01-01

    Recent studies revealed that a substantial proportion of patients with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase and cytokine receptors, such as ABL1, PDGFRB, JAK2 and CRLF2, which are targeted by tyrosine kinase inhibitors (TKIs). In the present study, transcriptome analysis or multiplex reverse transcriptase-PCR analysis of 373 BCP-ALL patients without recurrent genetic abnormalities identified 29 patients with kinase fusions. Clinically, male predominance (male/female: 22/7), older age at onset (mean age at onset: 8.8 years) and a high white blood cell count at diagnosis (mean: 94 200/μl) reflected the predominance of National Cancer Institute high-risk (NCI-HR) patients (NCI-standard risk/HR: 8/21). Genetic analysis identified three patients with ABL1 rearrangements, eight with PDGFRB rearrangements, two with JAK2 rearrangements, three with IgH-EPOR and one with NCOR1-LYN. Of the 14 patients with CRLF2 rearrangements, two harbored IgH-EPOR and PDGFRB rearrangements. IKZF1 deletion was present in 16 of the 22 patients. The 5-year event-free and overall survival rates were 48.6±9.7% and 73.5±8.6%, respectively. The outcome was not satisfactory without sophisticated minimal residual disease-based stratification. Furthermore, the efficacy of TKIs combined with conventional chemotherapy without allogeneic hematopoietic stem cell transplantation in this cohort should be determined. PMID:27176795

  2. Anaerobic biodegradation of biofuels and BTEX compounds in aquifer sediment, with implications for modeling transport and fate (Philadelphia)

    EPA Science Inventory

    Biofuels, such as ethanol and biodiesel, are a growing component of the nation’s fuel supply. Ethanol is the primary biofuel in the US market, distributed as a blend with petroleum gasoline, in concentrations ranging from 10% ethanol (E10) to 85% ethanol (E85). Biodiesel, made ...

  3. 78 FR 76142 - Adequacy Status of the Submitted Attainment Plan for the Delaware Portion of the Philadelphia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... process for determining the adequacy of submitted SIP budgets in a July 1, 2004 preamble starting at 69 FR... conformity regulations to implement the 1997 PM 2.5 NAAQS in July 2004 and May 2005 (69 FR 40004, July 1, 2004 and 70 FR 24280, May 6, 2005, respectively). Those actions were not part of the final...

  4. Bosutinib in the treatment of patients with Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia: an overview

    PubMed Central

    Shen, Ann Q.; Wilson, Nicole M.; Gleason, Shannon L.

    2014-01-01

    Bosutinib is an orally bioavailable SRC/ABL tyrosine kinase inhibitor with activity against all phases of resistant chronic myeloid leukemia that do not express the T315I or V299L ABL kinase domain mutations. Bosutinib has a unique toxicity profile that is manageable. This paper provides an overview of bosutinib, covering pharmacodynamics and pharmacokinetic properties, results of treatment in newly diagnosed and previously treated chronic myeloid leukemia patients, as well as common side effects. PMID:24490020

  5. Existing Whole-House Solutions Case Study: 56th and Walnut: A Philly Gut Rehab Development, Philadelphia, Pennsylvania

    SciTech Connect

    2013-11-01

    Load-bearing brick-masonry multifamily buildings are prevalent in urban areas across much of the Northeast and mid-Atlantic. In most instances, these buildings are uninsulated unless they have been renovated within the past two decades. Affordable housing capital budgets typically limit what can be spent and energy improvements often take a back seat to basic capital improvements such as interior finish upgrades and basic repairs. The Consortium for Advanced Residential Buildings (CARB) is researching cost-effective solution packages for significant energy efficiency and indoor air-quality improvements in these urban buildings.

  6. IMPLICATIONS OF SELECTING ALTERNATIVE EXPOSURE METRICS IN ANALYZING THE RELATIONSHIPS BETWEEN PM AND ACUTE MORTALITY AND MORBIDITY IN PHILADELPHIA

    EPA Science Inventory

    The US EPA National Exposure Research Laboratory (NERL) has developed a population exposure model for particulate matter (PM), called the Stochastic Human Exposure and Dose Simulation (SHEDS-PM) model. The SHEDS-PM model estimates the population distribution of PM exposures by...

  7. Call for Papers. Correctional Education Association International Conference (39th, Philadelphia, Pennsylvania, July 1-4, 1984).

    ERIC Educational Resources Information Center

    Correctional Education Association.

    Authors and titles of the 15 papers in this volume are as follows: "A Follow-up Study of Vocational Education Graduates from the Ohio Central School System during Fiscal Year 1979" (Earl R. Schaeffer, Theodore P. Shannon); "Legal and Policy Dimensions of Functional Illiteracy among Post-Secondary Inmate Students" (Paul Moke, Jarrell Holloway);…

  8. Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950–2009)

    PubMed Central

    Daniels, Robert D; Kubale, Travis L; Yiin, James H; Dahm, Matthew M; Hales, Thomas R; Baris, Dalsu; Zahm, Shelia H; Beaumont, James J; Waters, Kathleen M; Pinkerton, Lynne E

    2015-01-01

    Objectives To examine mortality patterns and cancer incidence in a pooled cohort of 29 993 US career firefighters employed since 1950 and followed through 2009. Methods Mortality and cancer incidence were evaluated by life table methods with the US population referent. Standardised mortality (SMR) and incidence (SIR) ratios were determined for 92 causes of death and 41 cancer incidence groupings. Analyses focused on 15 outcomes of a priori interest. Sensitivity analyses were conducted to examine the potential for significant bias. Results Person-years at risk totalled 858 938 and 403 152 for mortality and incidence analyses, respectively. All-cause mortality was at expectation (SMR=0.99, 95% CI 0.97 to 1.01, n=12 028). There was excess cancer mortality (SMR=1.14, 95% CI 1.10 to 1.18, n=3285) and incidence (SIR=1.09, 95% CI 1.06 to 1.12, n=4461) comprised mainly of digestive (SMR=1.26, 95% CI 1.18 to 1.34, n=928; SIR=1.17, 95% CI 1.10 to 1.25, n=930) and respiratory (SMR=1.10, 95% CI 1.04 to 1.17, n=1096; SIR=1.16, 95% CI 1.08 to 1.24, n=813) cancers. Consistent with previous reports, modest elevations were observed in several solid cancers; however, evidence of excess lymphatic or haematopoietic cancers was lacking. This study is the first to report excess malignant mesothelioma (SMR=2.00, 95% CI 1.03 to 3.49, n=12; SIR=2.29, 95% CI 1.60 to 3.19, n=35) among US firefighters. Results appeared robust under differing assumptions and analytic techniques. Conclusions Our results provide evidence of a relation between firefighting and cancer. The new finding of excess malignant mesothelioma is noteworthy, given that asbestos exposure is a known hazard of firefighting. PMID:24142974

  9. Buying Food on Sale: A Mixed Methods Study With Shoppers at an Urban Supermarket, Philadelphia, Pennsylvania, 2010–2012

    PubMed Central

    Kumanyika, Shiriki K.; Stites, Shana D.; Singletary, S. Brook; Cooblall, Clarissa; DiSantis, Katherine Isselmann

    2014-01-01

    Introduction The obesity epidemic has drawn attention to food marketing practices that may increase the likelihood of caloric overconsumption and weight gain. We explored the associations of discounted prices on supermarket purchases of selected high-calorie foods (HCF) and more healthful, low-calorie foods (LCF) by a demographic group at high risk of obesity. Methods Our mixed methods design used electronic supermarket purchase data from 82 low-income (primarily African American female) shoppers for households with children and qualitative data from focus groups with demographically similar shoppers. Results In analyses of 6,493 food purchase transactions over 65 weeks, the odds of buying foods on sale versus at full price were higher for grain-based snacks, sweet snacks, and sugar-sweetened beverages (odds ratios: 6.6, 5.9, and 2.6, respectively; all P < .001) but not for savory snacks. The odds of buying foods on sale versus full price were not higher for any of any of the LCF (P ≥ .07). Without controlling for quantities purchased, we found that spending increased as percentage saved from the full price increased for all HCF and for fruits and vegetables (P ≤ .002). Focus group participants emphasized the lure of sale items and took advantage of sales to stock up. Conclusion Strategies that shift supermarket sales promotions from price reductions for HCF to price reductions for LCF might help prevent obesity by decreasing purchases of HCF. PMID:25188276

  10. Innovation for Strength. Proceedings of the Annual Accreditation and Quality Assurance Conference (Philadelphia, Pennsylvania, December 7-8, 1998).

    ERIC Educational Resources Information Center

    Commission on Higher Education, Philadelphia, PA. Middle States Association of Colleges and Schools.

    These proceedings of the annual accreditation and quality assurance conference present the following papers: "The Coming Revolution in Higher Education" (Arthur Levine); "Corporate/College Alliances" (Jeanne C. Meister); "Why Are We Educators?" (Catharine R. Stimpson); "Serving an Increasingly Adult Student Population: Lessons from Nordstrom and…

  11. Another Philadelphia Story: Mobilizing Resistance and Widening the Educational Imagination in the Midst of Corporate Assault on the Public Sphere

    ERIC Educational Resources Information Center

    Fine, Michelle

    2013-01-01

    Information about the MIT Media Lab PLATFORM, a Summit of Innovators, is presented. This Summit was comprised of engineers, computer scientists, coders, activists, designers, and technology wizards, a gathering of people of color who have been remarkably successful, provocative, and creative against the odds. The event enabled the author and other…

  12. Site handbook: data acquisition system information, Shelly Ridge Program Center for the Girl Scouts of greater Philadelphia, Miquon, Pennsylvania

    SciTech Connect

    Not Available

    1985-01-01

    Data were collected at the Shelly Ridge Girl Scout Center using an Aeolian Kinetics PDL-24 data acquisition system. Instantaneous data readings were recorded each 15 seconds by the microprocessor. These channel readings were then averaged to produce hourly values which were then stored on an audio cassette. These hourly data were then transcribed to the AIAF archive. The Girl Scout Center features an 861 square foot unvented Trombe wall, a direct gain sunspace, and two rooftop collectors for heating domestic water.

  13. Molecular cloning of the breakpoints of a complex Philadelphia chromosome translocation: identification of a repeated region on chromosome 17.

    PubMed Central

    McKeithan, T W; Warshawsky, L; Espinosa, R; LeBeau, M M

    1992-01-01

    Complex translocations in chronic myelogenous leukemia involve various chromosomes, in addition to chromosomes 9 and 22, in a nonrandom fashion. We have analyzed the DNA from leukemia cells characterized by a complex translocation, t(9;22;10;17)(q34;q11;p13;q21), by using the techniques of Southern blot hybridization, in situ hybridization, and molecular cloning; one of the breakpoints is at 17q21, a band that is frequently involved in complex 9;22 translocations. All of the breakpoint junctions and the corresponding normal sequences from the four involved chromosomes have been molecularly cloned. Restriction mapping is consistent with a simple concerted exchange of chromosomal material among the four chromosomes, except that additional changes appeared to have occurred within the chromosome 17 sequences. The cloned sequences on chromosome 17 at band q21 were found to be repeated in normal cells. By fluorescence in situ hybridization, a strong signal is seen at 17q21, but a weaker signal is also present at 17q23. By comparison with other primate species, an inversion in chromosome 17 during evolution appears to be responsible for the splitting of the cluster of repeat units in normal human cells. Images PMID:1594595

  14. The District Role in Supporting College and Career Readiness for Students: Perspectives from Long Beach, Albuquerque, and Philadelphia

    ERIC Educational Resources Information Center

    Duffy, Helen; Darwin, Marlene

    2013-01-01

    Current federal policy and the broader national agenda focus on education as an integral element of a strong and competitive United States economy, and a well-educated workforce is essential to economic growth. To help build this workforce, state education agencies, local education agencies, and schools need to develop comprehensive approaches to…

  15. Sensor fusion II: Human and machine strategies; Proceedings of the Meeting, Philadelphia, PA, Nov. 6-9, 1989

    NASA Technical Reports Server (NTRS)

    Schenker, Paul S. (Editor)

    1990-01-01

    Various papers on human and machine strategies in sensor fusion are presented. The general topics addressed include: active vision, measurement and analysis of visual motion, decision models for sensor fusion, implementation of sensor fusion algorithms, applying sensor fusion to image analysis, perceptual modules and their fusion, perceptual organization and object recognition, planning and the integration of high-level knowledge with perception, using prior knowledge and context in sensor fusion.

  16. Philadelphia gas works medium-Btu coal gasification project: environmental assessment. [GKT supplied by Krupp-Koppers

    SciTech Connect

    Not Available

    1981-12-01

    The coal gasification plant will occupy a 43-acre site, known as the Riverside Site, located along the Delaware River next to Port Richmond between the Betsy Ross and Benjamin Franklin Bridges. The cleared site was previously used for industrial purposes and has a G-2 industrial zoning. Adverse impacts during the construction phase of the project are not expected to be significantly different than those occurring during any major industrial construction project. During operation of the coal gasification facility, specific mitigative measures have been designed into the facility to avoid adverse environmental impacts wherever possible. In addition to these extensive engineering safeguards, elaborate monitoring and control instrumentation shall be used. The GKT entrained bed, oxygen-blown gasification process provided by Krupp/Koppers was selected because it is a commercially proven system and because of its positive environmental characteristics such as its ability to gasify many coal types and the fact that it does not produce tars, phenols, or ammonia. During gasification of the coal, pollutants such as heavy metals in the coal are concentrated into the slag and ash. None of these pollutants are found in the product gas. The facility will produce 250 tpd of non-hazardous slag and fly ash. The combined slag and fly ash will occupy 347 cubic yards per day of landfill volume. Available haulers and landfills have been identified.A sophisticated health and safety program will include appropriate monitoring instruments for CO, H/sub 2/, H/sub 2/S, polynuclear aromatic hydrocarbons, organic compounds, and coal dust. Air emissions from operation of the coal gasification plant are not considered significant. Dust control systems have been designed into the facility to minimize fugitive dust emissions.

  17. The Information Bazaar; Sixth Annual National Colloquium on Information Retrieval, May 8-9, 1969, Philadelphia, Pennsylvania.

    ERIC Educational Resources Information Center

    Schultz, Louise, Ed.

    The 31 papers in this proceedings cover social as well as technical issues, mathematical models and formal logic systems, applications descriptions, program design, cost analysis, and predictions. The papers are grouped into sessions including: privacy and information technology, describing documents, information dissemination systems, public and…

  18. EnergyWorks Final Report: A Better Buildings Neighborhood Program in the Five-County Greater Philadelphia Region

    SciTech Connect

    Gajewski, Katherine

    2014-03-05

    This report covers the grant performance period of July 1, 2010-September 30, 2013 and discusses of the program design, outcomes and best practices as they relate to the following six areas: 1. Institutional Design and Business Model; 2. Program Design and Customer Experience; 3. Driving Demand; 4. Workforce Development; 5. Financing and Incentives; 6. Data and Evaluation.

  19. The Nation's Report Card Science 2009 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 4, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2011

    2011-01-01

    Guided by a new framework, the National Assessment of Educational Progress (NAEP) science assessment was updated in 2009 to keep the content current with key developments in science, curriculum standards, assessments, and research. The 2009 framework organizes science content into three broad content areas. Physical science includes concepts…

  20. The Nation's Report Card Science 2009 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 8, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2011

    2011-01-01

    Guided by a new framework, the National Assessment of Educational Progress (NAEP) science assessment was updated in 2009 to keep the content current with key developments in science, curriculum standards, assessments, and research. The 2009 framework organizes science content into three broad content areas. Physical science includes concepts…