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Sample records for airport philadelphia philadelphia

  1. 75 FR 21386 - Philadelphia International Airport, Capacity Enhancement Program, Environmental Impact Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ..., Environmental Impact Statement, Announcement of a Preferred Alternative AGENCY: Federal Aviation Administration... Alternative for the Philadelphia International Airport, Capacity ] Enhancement Program, Environmental Impact... the process of completing an Environmental Impact Statement (EIS) for the Philadelphia...

  2. Synthetic aperture radar imagery of airports and surrounding areas: Philadelphia Airport

    NASA Technical Reports Server (NTRS)

    Onstott, Robert G.; Gineris, Denise J.

    1990-01-01

    The statistical description of ground clutter at an airport and in the surrounding area is addressed. These data are being utilized in a program to detect microbursts. Synthetic Aperture Radar (SAR) data were collected at the Philadelphia Airport. These data and the results of the clutter study are described. This 13 km x 10 km scene was imaged at 9.38 GHz and HH-polarization and contained airport grounds and facilities (6 percent), industrial (14 percent), residential (14 percent), fields (10 percent), forest (8 percent), and water (33 percent). Incidence angles ranged from 40 to 84 deg. Even at the smallest incidence angles, the distributed targets such as forest, fields, water, and residential rarely had mean scattering coefficients greater than -10 dB. Eighty-seven percent of the image had scattering coefficients less than -17.5 dB. About 1 percent of the scattering coefficients exceeded 0 dB, with about 0.1 percent above 10 dB. Sources which produced the largest cross sections were largely confined to the airport grounds and areas highly industrialized. The largest cross sections were produced by observing broadside large buildings surrounded by smooth surfaces.

  3. 77 FR 43136 - Approval of Noise Compatibility Program for Philadelphia International Airport, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Program which sets forth the measures taken or proposed by the airport operator for the reduction of... with respect to which measures should be recommended for action. The FAA's approval or disapproval of Part 150 program recommendations is measured according to the standards expressed in Part 150 and...

  4. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  5. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  6. The Philadelphia Experiment.

    ERIC Educational Resources Information Center

    Mathews, Jay

    2003-01-01

    Describes how the School District of Philadelphia turned over 20 schools to Edison Schools, the for-profit school management firm. Presents the cases of both the opponents and proponents of Edison Schools. Outlines the academic and financial records of the Edison firm and its efforts in Philadelphia. (WFA)

  7. Philadelphia's New World Symphony.

    ERIC Educational Resources Information Center

    Roth, Edith Brill

    1980-01-01

    An outgrowth of a school for immigrants' children, the Philadelphia Settlement Music School offers music education to children of all races and classes, with the primary aim of teaching children to enjoy and understand music throughout their lives. (SK)

  8. View northwest of commander's office for Philadelphia Naval Base. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View northwest of commander's office for Philadelphia Naval Base. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Commander's Office-Naval Base, League Island, Philadelphia, Philadelphia County, PA

  9. Partners in Philadelphia.

    ERIC Educational Resources Information Center

    Mezzacappa, Dale

    2001-01-01

    University of Pennsylvania professor Lee Benton saw fire-ravaged city blocks in Philadelphia as an opportunity to involve the university in remaking K-12 education. Penn successfully initiated various community-outreach programs, focusing on building a community school and encouraging cooperation between college students and neighborhoods. (MLH)

  10. Philadelphia and the Tomato.

    ERIC Educational Resources Information Center

    Smith, Andrew F.; Kling, Tatiana

    This booklet describes for elementary students the many contributions of people, traveling many places, over many years to bring the tomato to Philadelphia. The booklet includes the following: (1) "Introduction to the Tomato"; (2) "Where Does the Tomato Come From?"; (3) "The Spanish Tomato"; (4) "The Philadelphia…

  11. School Closings in Philadelphia

    ERIC Educational Resources Information Center

    Jack, James; Sludden, John

    2013-01-01

    In 2012, the School District of Philadelphia closed six schools. In 2013, it closed 24. The closure of 30 schools has occurred amid a financial crisis, headlined by the district's $1.35 billion deficit. School closures are one piece of the district's plan to cut expenditures and close its budget gap. The closures are also intended to make…

  12. 12. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  13. 10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  14. 9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  15. 8. Pennsylvania Railroad: 30th Street Station Powerhouse. Philadelphia, Philadelphia Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Pennsylvania Railroad: 30th Street Station Powerhouse. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  16. 11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  17. View westsouthwest of marine railway at reserve basin of Philadelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View west-southwest of marine railway at reserve basin of Philadelphia Naval Shipyard. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Reserve Basin & Marine Railway, League Island, Philadelphia, Philadelphia County, PA

  18. 77 FR 3545 - Receipt of Noise Compatibility Program and Request for Review for Philadelphia International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Noise Compatibility Program and Request for Review for Philadelphia International Airport, Philadelphia... Administration (FAA) announces that it is reviewing a proposed noise compatibility program that was submitted for Philadelphia International Airport under the provisions of 49 U.S.C. 47504 (the Aviation Safety and...

  19. 76 FR 77669 - Amendment of Class D and E Airspace; North Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... airspace at Northeast Philadelphia Airport, North Philadelphia, PA, due to the closing of Willow Grove... reconfigured due to the closing of the Willow Grove Naval Air Station and Warminster NAWC. The boundary...

  20. Overview from west bank of Schuykill River. Philadelphia & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Overview from west bank of Schuykill River. - Philadelphia & Reading Railroad, Bridge at West Falls, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  1. 2. Photocopy of the fountain in front of Philadelphia Museum ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of the fountain in front of Philadelphia Museum of Art, ca. 1928, courtesy of Philadelphia Museum of Art - Fountain of the Sea Horses, Aquarium Lane, Philadelphia, Philadelphia County, PA

  2. Philadelphia's Parkway Program: An Evaluation.

    ERIC Educational Resources Information Center

    Wofford, Joan; Ross, Joanne

    The Parkway Program is the prototype school-without-walls created by the School District of Philadelphia in 1967. The program presently consists of four units of approximately 200 students (chosen by lottery from throughout the city), ten teachers, ten to 12 interns, and a Unit Head and administrative assistant housed in four separate non-school…

  3. Building 21: B21 Philadelphia

    ERIC Educational Resources Information Center

    EDUCAUSE, 2015

    2015-01-01

    As a non-selective neighborhood high school in the School District of Philadelphia, B21's mission is to empower networks of learners to connect with their passions and build agency to impact their world. Building 21 is organized into studios, workshops, and advisories. Core studios engage students in project-based learning. Blended learning…

  4. Philadelphia's "Servant-Leader" Superintendent

    ERIC Educational Resources Information Center

    Puente, Kelly

    2012-01-01

    This article profiles William Hite, Jr., a longtime educator and administrator, who began his career more than two decades ago as a high school athletic coach. Hite says his biggest passion is educating young people. And one of the best ways to serve students, he says, is by listening. Hite, 51, assumed his duties as Philadelphia's new…

  5. 21. Scrapping In Dry Dock #4. Naval Shipyard Philadelphia. February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Scrapping In Dry Dock #4. Naval Shipyard Philadelphia. February 18, 1946. Original Photograph In Collection of National Archives, Mid-Atlantic Regional Records Center, Philadelphia. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  6. Philadelphia

    Atmospheric Science Data Center

    2014-05-15

    ... Service and the state of New Jersey. A portion of the Appalachian Mountains in Pennsylvania is captured in the upper left corner. The ... location:  United States region:  Eastern United States Order:  25 ...

  7. 11. SOUTH (REAR) ELEVATION OF THE PHILADELPHIA SAVING FUND SOCIETY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. SOUTH (REAR) ELEVATION OF THE PHILADELPHIA SAVING FUND SOCIETY (PSFS) BUILDING WITH MEETING HOUSE CORNICE IN FOREGROUND. - Twelfth Street Meeting House, 20 South Twelfth Street, Philadelphia, Philadelphia County, PA

  8. 2. Photocopy of photograph (from Moses King, Philadelphia and Notable ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of photograph (from Moses King, Philadelphia and Notable Philadelphians , 1902, p. 260) OBLIQUE VIEW, SHOWING SOUTH (FRONT) AND EAST(SIDE) ELEVATIONS - Old U.S. Mint, Chestnut & Juniper Streets, Philadelphia, Philadelphia County, PA

  9. Interior view; Street Car Waiting House North Philadelphia Station, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view; Street Car Waiting House - North Philadelphia Station, Street Car Waiting House, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  10. 1. BEGINNING OF RAILWAY SUPERSTRUCTURE IN PHILADELPHIA COUNTY. FACING EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. BEGINNING OF RAILWAY SUPERSTRUCTURE IN PHILADELPHIA COUNTY. FACING EAST DOWN MARKET STREET. - Market Street Elevated Railway, Market Street between Sixty-ninth & Forty-sixth Streets, Philadelphia, Philadelphia County, PA

  11. Philadelphia Youth Network. 2005 Annual Report

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2005

    2005-01-01

    This paper presents the annual report of the Philadelphia Youth Network (PYN) for 2005. Throughout the year, PYN's members continued their focus on linking work and education in ways that promote access for young people to Philadelphia's growth economy, and supply a high-quality workforce to power the City's continued economic development. [For…

  12. Comprehensive District Reform: Philadelphia's Grand Experiment.

    ERIC Educational Resources Information Center

    Useem, Elizabeth; Balfanz, Robert

    2002-01-01

    This report describes "Philadelphia's Grand Experiment" in comprehensive school district reform, from its conception through its initial months of implementation. In 2001, as part of the remedy for low student performance, the governor ordered the state to take over governance of the Philadelphia School District, with a substantial…

  13. Philadelphia Eagles Honor NASA Astronaut Chris Ferguson

    NASA Video Gallery

    NASA astronaut Chris Ferguson returned to his hometown on Nov. 7 to serve as the Philadelphia Eagles' Honorary Captain during the NFL's "Monday Night Football" game. The Eagles hosted the Chicago B...

  14. Philadelphia Printing and Publishing, 1876-1976

    ERIC Educational Resources Information Center

    Whitehead, Thomas M.

    1976-01-01

    Two Philadelphia printing histories, both reflecting the relationship of printing to publishing, are examined in this article: the manufacture by the publisher of his own product and the development and commercialization of the photomechanical halftone process. (Author)

  15. 76 FR 19518 - Notice of Intent to Rule on Request To Release Airport Property at the Northeast Philadelphia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ...-1595 and at the FAA Harrisburg Airports District Office: Lori K. Pagnanelli, Manager, Harrisburg... CONTACT: Lori Ledebohm, Community Planner, Harrisburg Airports District Office location listed above. The... the extent practicable. Issued in Camp Hill, Pennsylvania, April 1, 2011. Lori K. Pagnanelli,...

  16. 76 FR 49383 - Proposed Amendment of Class D and E Airspace; North Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... Airport, North Philadelphia, PA, due to the closing of Willow Grove Naval Air Station and Warminster NAWC... due to the closing of Willow Grove Naval Air Station and Warminster NAWC. Class D and Class E...

  17. NorthEast view; Platform, canopy, and freight elevator North Philadelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    North-East view; Platform, canopy, and freight elevator - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  18. 3. DETAIL OF WEST TOWER, LOOKING NE. Philadelphia & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. DETAIL OF WEST TOWER, LOOKING NE. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  19. 2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. Philadelphia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  20. 1. 3/4 VIEW, LOOKING NE. Philadelphia & Reading Railroad, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 3/4 VIEW, LOOKING NE. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  1. 4. VIEW RECONSTRUCTED TOWER, LOOKING NNE. Philadelphia & Reading ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW RECONSTRUCTED TOWER, LOOKING NNE. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  2. EPAs Educational Exhibit Honored at Philadelphia Flower Show

    EPA Pesticide Factsheets

    PHILADELPHIA (March 8, 2016) - The U.S. Environmental Protection Agency's exhibit at the 2016 Philadelphia Flower Show was recognized with three prestigious awards. The awards include a Gold Medal Award by the Pennsylvania Horticultural Society for

  3. 14. LION SCULPTURE, AT THE PHILADELPHIA MUSEUM OF ART, MOVED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. LION SCULPTURE, AT THE PHILADELPHIA MUSEUM OF ART, MOVED FROM MERCHANTS' EXCHANGE, WHERE IT RESTED ON THE STAIR WALL OF SIDE ENTRANCE STAIRS. (A REPLACEMENT LION HAS BEEN PLACED IN THE ORIGINAL SITE, AS DID ANOTHER REPLACEMENT IN THE OTHER SIDE OF THE BUILDING. FOR THIS LATTER REPLACEMENT SEE PA-1028-15). A VIEW OF THE MUSEUM IS IN THE BACKGROUND - Philadelphia Exchange Company, 143 South Third Street, Philadelphia, Philadelphia County, PA

  4. 161. Photocopy of photograph in the Philadelphia city Archives, dated ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    161. Photocopy of photograph in the Philadelphia city Archives, dated July 8, 1930, showing east elevation of North Entrance House with William Rush's allegorical sculpture of 'Schuylkill Chained' in place over portal to Entrance House. If reproduced, please credit Philadelphia Historical Commission. In 1930, this structure is identified as the Elevator Shaft Building. - Fairmount Waterworks, East bank of Schuylkill River, Aquarium Drive, Philadelphia, Philadelphia County, PA

  5. South Philadelphia Passive Sampler and Sensor Study

    EPA Science Inventory

    From June 2013 to March 2015, a total of 41 two-week duration passive sampler deployments were conducted at 17 sites in South Philadelphia, with results for benzene discussed here. Complementary time-resolved measurements with lower cost prototype fenceline sensors and an open-pa...

  6. Philadelphia's Independence Starts Here: Disability Arts Festival

    ERIC Educational Resources Information Center

    Smith, Mimi Kenney

    2008-01-01

    In tribute to Philadelphia's world-changing past, Festival partners dubbed the month-long Disability Arts Festival "Independence Starts Here." Through it, they hoped to begin to change the future for over 675,000 people with disabilities in the area and their families. Led by Amaryllis Theatre Company, which now also serves as VSA arts…

  7. The Philadelphia School District's Ongoing Financial Crisis

    ERIC Educational Resources Information Center

    Caskey, John; Kuperberg, Mark

    2014-01-01

    This article describes the budget crisis that the School District of Philadelphia has faced for the past few years. Three specific events triggered the 2012 crisis: an abrupt reduction in federal and state funding, the inability of the district to cut many of its costs, and political pressures on the district to spend available revenues in a given…

  8. Philadelphia's Renaissance Schools Initiative after Four Years

    ERIC Educational Resources Information Center

    Stratos, Kati; Wolford, Tonya; Reitano, Adrienne

    2015-01-01

    In 2010-2011, the School District of Philadelphia (the District) launched its Renaissance Schools Initiative, a program designed to dramatically improve student achievement in the District's lowest performing schools. Some schools became Promise Academies, based on the federal turnaround model, and remained District-operated neighborhood schools.…

  9. The State of Black Philadelphia 1982.

    ERIC Educational Resources Information Center

    Lewis, Claude, Ed.; Perry, Carrolle, Ed.

    The articles in this report describe current social conditions of blacks in Philadelphia, Pennsylvania, and examine how government policies can affect such conditions. Brenda Maisha Jefferson Jackson discusses black housing opportunities and the negative impact of racial discrimination, political powerlessness, and economics on these…

  10. Philadelphia, Pennsylvania: Solar in Action (Brochure)

    SciTech Connect

    Not Available

    2011-10-01

    This brochure provides an overview of the challenges and successes of Philadelphia, PA, a 2008 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  11. Amachi: Mentoring Children of Prisoners in Philadelphia.

    ERIC Educational Resources Information Center

    Jucovy, Linda

    This report documents the work of Amachi, a mentoring program for children of incarcerated and formerly incarcerated parents in Philadelphia, Pennsylvania. Volunteers are recruited from inner-city congregations to provide one-to-one mentoring to the children. Beyond being the source of mentors, the congregations are a key part of the initiative.…

  12. South Philadelphia Passive Sampler and Sensor Study

    EPA Science Inventory

    Starting in June 2013, the United States Environmental Protection Agency (U.S. EPA) and the City of Philadelphia Air Measurements Services began collaborative research on the use of passive samplers (PSs) and stand-alone air measurement (SAM) systems to improve information on the...

  13. 20. Scrapping C112 U.S.S. Marblehead. Naval Shipyard Philadelphia. January 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Scrapping C1-12 U.S.S. Marblehead. Naval Shipyard Philadelphia. January 10, 1946. Original Photograph In Collection of National Archives, Mid-Atlantic Regional Records Center, Philadelphia. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  14. Selected contributions to neurology by Philadelphia neurologists since 1980.

    PubMed

    Asbury, Arthur K; Sperling, Michael R; Aguirre, Geoffrey Karl; Liu, Grant T

    2010-01-01

    On the occasion of the 125th anniversary of the Philadelphia Neurologic Society, 3 short talks were given that highlighted accomplishments by Philadelphia's neurologists over the past 30 years. The theme for the celebration was "Contributions to Neurology by Philadelphia Neurologists, 1980-2008." Each of the 3 speakers was chosen because of his contributions and the sequential time frames in which they occurred. Dr. Arthur K. Asbury detailed the original description of the Lewis-Sumner syndrome, Dr. Michael R. Sperling summarized the growth of epilepsy surgery in Philadelphia, and Dr. Geoffrey K. Aguirre depicted the roots of functional magnetic resonance imaging in Philadelphia.

  15. Hydrologic data for aquifers in Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Paulachok, G.N.; Wood, C.R.; Norton, L.J.

    1984-01-01

    Selected data on the ground-water resources of Philadelphia, Pennsylvania, are presented in this report. Information including water levels and data on aquifers is tabulated for 828 wells and 3 sumps. Chemical analyses are given for 1,467 water samples obtained from 205 sites and include 103 analyses for trace elements and 68 analyses for volatile organic compounds. An index of geophysical logs including gamma ray, neutron, caliper, fluid conductivity, fluid velocity, single-point resistance, spontaneous potential, and temperature determinations made in 51 wells is also presented. Data-collection sites are shown on a 1:50,000 scale location map.

  16. Impact of Community College of Philadelphia Allied Health Programs on the Philadelphia Region. Report #117.

    ERIC Educational Resources Information Center

    Philadelphia Community Coll., PA.

    This report discusses the Allied Health programs at Community College of Philadelphia (CCP): (1) Clinical Laboratory Technician; (2) Dental Assisting Hygiene; (3) Dental Assisting Certificate; (4) Diagnostic Medical Imaging; (5) Dietetic Technician; (6) Health Information Technology; (7) Medical Assisting and Office Management; (8) Nursing; and…

  17. 78 FR 27025 - Modification of Class B Airspace; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... modifies the Philadelphia, PA, Class B airspace area to ensure the containment of large turbine-powered... in the Philadelphia terminal area. DATES: Effective Date: 0901 UTC, July 25, 2013. The Director of the Federal Register approves this incorporation by reference action under 1 CFR part 51, subject...

  18. Philadelphia's Renaissance Schools: Start up and Early Implementation. Executive Summary

    ERIC Educational Resources Information Center

    Research for Action, 2011

    2011-01-01

    In April 2009, Superintendent Arlene Ackerman announced her reform plan for the School District of Philadelphia (the District)--"Imagine 2014". Among other major initiatives, "Imagine 2014" laid the groundwork for Philadelphia's Renaissance Schools Initiative. The Renaissance Initiative, set to enter its second year in 2011-12, is an effort to…

  19. Time's Up: Applying Teacher Management Skills to Solving Philadelphia's Problems

    ERIC Educational Resources Information Center

    Lax, Zach

    2013-01-01

    Teachers are natural problem solvers, and they should be using this quality to their advantage when it comes to solving the systemic issues that plague Philadelphia's education system. Many of the articles in this issue have already gone into great detail about what is happening in Philadelphia. Torch Lytle has provided a summary of the recent…

  20. South Philadelphia Passive Sampler Method project communication sheet

    EPA Science Inventory

    The Environmental Protection Agency, Office of Research and Development (EPA ORD), EPA Region 3, and the City of Philadelphia Air Measurements Services (AMS) are collaborating on research project in South Philadelphia starting in the spring of 2013. This project investigates how...

  1. Strategies for Talent Management: Greater Philadelphia Companies in Action

    ERIC Educational Resources Information Center

    Council for Adult and Experiential Learning (NJ1), 2008

    2008-01-01

    Human capital is one of the critical issues that impacts the Greater Philadelphia region's ability to grow and prosper. The CEO Council for Growth (CEO Council) is committed to ensuring a steady and talented supply of quality workers for this region. "Strategies for Talent Management: Greater Philadelphia Companies in Action" provides…

  2. For-Profit Writes Mandatory Courses for Philadelphia High Schools

    ERIC Educational Resources Information Center

    Olson, Lynn

    2005-01-01

    This article reports how Kaplan K12 Learning Services Group, a division of Kaplan Inc., has developed a new, standardized college-preparatory curriculum for the Philadelphia school district. The curriculum, which made its debut in the Philadelphia district in 2005, was a critical element in the district leadership's plan to improve secondary…

  3. A Trip to Historic Philadelphia on the Web.

    ERIC Educational Resources Information Center

    Wilson, Elizabeth K.

    1997-01-01

    Describes an electronic field trip to colonial Philadelphia (Pennsylvania). The historic locale has generated enough websites (Philadelphia Historic District, Betsy Ross homepage, and the Franklin Institute Science Museum) for students to take a virtual tour of the colonial capital. Suggests structuring the activity as a know-want-learn (KWL)…

  4. Marylanders defeat Philadelphia: yellow fever updated.

    PubMed Central

    Woodward, T. E.; Beisel, W. R.; Faulkner, R. D.

    1976-01-01

    Those strategic points which influence this amateur historian to declare a victory for Baltimore and Maryland over Philadelphia are: I. Based upon clinical and epidemiological data, two Marylanders, Potter and Davidge, were among the first to contest Rush and his contagion theory; they told him so and published their views. To prove this point, Potter went to the extreme of inoculating himself with presumedly infected material. Stubbins Ffirth, a young University of Pennsylvania medical student, did the same four years later. To Rush's credit was ultimate abandonment of his originally held views. II. John Crawford, of Baltimore, although not the originator of the insect concept of transmission of infectious agents, published his concepts in 1811. III. Henry Rose Carter, a Maryland graduate, clearly delineated, in 1898, that after identification of an index case of yellow fever an extrinsic incubation period was necessary before the evolution of secondary cases. IV. James Carroll, another University of Maryland graduate, who worked as Deputy under Walter Reed with Lazear and Agramonte, helped prove Finlay's original concept that the Aedes aegypti mosquito was the natural vector of yellow fever. Carroll himself was the first experimentally induced case. V. Studies in primates provide new approaches for management of yellow fever. Nutritional support and treatment with specific anti-viral agents may be useful for therapy of human yellow fever. Maryland members of the Climatological are mindful of Philadelphia's rich medical heritage and of the many battles won in the City of Brotherly Love. Physicians in colonial and early America experienced The best and worst of times, theirs was an age of foolishness and belief, of incredulity and light, of darkness, despair and hope. This tale of two cities ends in peace. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 10 Fig. 11 PMID:822563

  5. RadNet Air Data From Philadelphia, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Philadelphia, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  6. Philadelphia chromosome duplication as a ring-shaped chromosome.

    PubMed

    Borjas-Gutierrez, Cesar; Gonzalez-Garcia, Juan Ramon

    2016-01-01

    The gain of a second copy of the Philadelphia chromosome is one of the main secondary chromosomal changes related to the clonal evolution of cells with t(9;22) in chronic myelogenous leukemia. This gain causes the acquisition of another copy of the BCR/ABL1 fusion gene. Isochromosomes of the der(22) chromosome or double minute chromosomes are well known to lead an increased copy number of BCR/ABL1 gene. There is no antecedent of Philadelphia chromosome duplication as a ring chromosome. A recent published report contains evidence that strongly suggests that the Philadelphia chromosome was duplicated as a ring chromosome, observation that was overlooked by the authors. The instability inherent to the ring chromosome increases the risk of emergence of clones containing more and more BCR/ABL1 gene copies, which would produce increased fitness for clonal selection, resulting in worsening of the patient's prognosis.

  7. Low incidence of painless thyroiditis in the Philadelphia area

    SciTech Connect

    Schorr, A.B.; Miller, J.L.; Shtasel, P.; Rose, L.I.

    1986-06-01

    Publications from the midwestern region of the United States have demonstrated an incidence of 14-23% of painless thyroiditis in hyperthyroid individuals. This possibly could represent a local phenomenon, and perhaps is not typical for other areas of the country. The 24 hour radioactive iodine uptakes in 152 consecutive hyperthyroid individuals in the Philadelphia area were evaluated. No patient in the series, with clinical and biochemical evidence of hyperthyroidism, had painless thyroiditis. It is concluded that the incidence of painless thyroiditis is markedly lower in the Philadelphia area than in the Midwest regions of the United States.

  8. EPA Funding to Temple University will help Revitalize Philadelphias North Kensington Area

    EPA Pesticide Factsheets

    PHILADELPHIA (March 27, 2015) Funding from the U.S. Environmental Protection Agency to Temple University will help plan for health, environmental and economic improvements for Philadelphia's Kensington area residents through the cleanup and reuse of brownf

  9. EPA Announces Excellence in Site Reuse Award for Philadelphia Freedom Valley YMCA

    EPA Pesticide Factsheets

    PHILADELPHIA (October 9, 2015) - Today, U.S. Environmental Protection Agency Mid-Atlantic Regional Administrator Shawn M. Garvin presented the Philadelphia Freedom Valley YMCA and its Vice President of Facilities, Michael Troupe, with a 2015 Excelle

  10. 78 FR 14359 - Verizon Business Networks Services, Inc., Specialist-Tech Customer Service, Philadelphia, PA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Employment and Training Administration Verizon Business Networks Services, Inc., Specialist-Tech Customer Service, Philadelphia, PA; Verizon Business Networks Services, Inc., Specialist-Tech Customer Service...-Tech Customer Service, Philadelphia, Pennsylvania and Verizon Business Networks Services,...

  11. South Philadelphia Passive Sampler and Sensor Study: Interim Report

    EPA Science Inventory

    Starting in June 2013, the United States Environmental Protection Agency (U.S. EPA) and the City of Philadelphia Air Measurements Services began collaborative research on the use of passive samplers (PSs) and stand-alone air measurement (SAM) systems to improve information on the...

  12. Item Response Theory Modeling of the Philadelphia Naming Test

    ERIC Educational Resources Information Center

    Fergadiotis, Gerasimos; Kellough, Stacey; Hula, William D.

    2015-01-01

    Purpose: In this study, we investigated the fit of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996) to an item-response-theory measurement model, estimated the precision of the resulting scores and item parameters, and provided a theoretical rationale for the interpretation of PNT overall scores by relating…

  13. The Library Company of Philadelphia: Historical Survey, Bibliography, Chronology.

    ERIC Educational Resources Information Center

    Sable, Martin H.

    1987-01-01

    Traces the history of the Library Company of Philadelphia, which was founded by Benjamin Franklin. Early book selection and scope of the collection, subsequent growth and development, and the various directors of the company are described. The bibliography includes publications of the Library Company and publications about the Library Company.…

  14. Systemwide Implementation of Project-Based Learning: The Philadelphia Approach

    ERIC Educational Resources Information Center

    Schwalm, Jason; Tylek, Karen Smuck

    2012-01-01

    Citywide implementation of project-based learning highlights the benefits--and the challenges--of promoting exemplary practices across an entire out-of-school time (OST) network. In summer 2009, the City of Philadelphia and its intermediary, the Public Health Management Corporation (PHMC), introduced project-based learning to a network of more…

  15. Detail, turntable manufactured by the "Light Railway Equipment Company, Philadelphia, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail, turntable manufactured by the "Light Railway Equipment Company, Philadelphia, Penna." This device turned seaplanes ninety degrees in their movement between storage in the hangars (to the left, out of view) and the Delaware River used for take-offs and landings. - Lazaretto Quarantine Station, Marine Aviation Hangars, Wanamaker Avenue and East Second Street, Essington, Delaware County, PA

  16. The politics of urban informality in Philadelphia's recovery house movement.

    PubMed

    Fairbanks II, Robert P

    2011-01-01

    There are some 60,000 vacant properties in the city of Philadelphia, 30,000 of which are abandoned row houses. In the neighbourhood of Kensington, street-level entrepreneurs have reconfigured hundreds of former working-class row homes to produce the Philadelphia recovery house movement: an extra-legal poverty survival strategy for addicts and alcoholics located in the city's poorest and most heavily blighted zones. The purpose of this paper is to explore, ethnographically, the ways in which informal poverty survival mechanisms articulate with the restructuring of the contemporary welfare state and the broader political economy of Philadelphia. It is argued that recovery house networks accommodate an interrelated set of political rationalities animated not only by retrenchment and the churning of welfare bodies, but also by the agency of informal operators and the politics of self-help. Working as an alternative and partially vestigial boundary institution or buffer zone to formal regimes of governance, the recovery house movement reflects the ‘other story’ of the new urban politics in Philadelphia.

  17. South Philadelphia Passive Sampler and Sensor Study - Interim Report

    EPA Science Inventory

    Starting in the June 2013, the U.S. EPA and the City of Philadelphia Air Measurements Services (AMS) began a collaborative research project to investigate how sensor-based, stand-alone air measurements (SAMs) and passive samplers (PSs) can help improve information on air pollutan...

  18. Short-Form Philadelphia Naming Test: Rationale and Empirical Evaluation

    ERIC Educational Resources Information Center

    Walker, Grant M.; Schwartz, Myrna F.

    2012-01-01

    Purpose: To create two matched short forms of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996) that yield similar results to the PNT for measuring anomia. Method: In Study 1, archived naming data from 94 individuals with aphasia were used to identify which PNT items should be included in the short forms. The 2…

  19. Renewing Schools: A Report on the Cluster Initiative in Philadelphia.

    ERIC Educational Resources Information Center

    Useem, Elizabeth L.

    From 1990 to 1993 PATHS/PRISM worked with five elementary schools and two middle schools in Philadelphia to try to bring about systemic change for schools serving low-income students. This Cluster Initiative attempted to achieve greater coordination of curriculum and instruction, to develop teacher-driven collegial processes, and to revamp school…

  20. Assessing Community College of Philadelphia: Student Outcomes and Improvement Strategies

    ERIC Educational Resources Information Center

    Ginsberg, Thomas

    2015-01-01

    This report examines the Community College of Philadelphia (CCP) and its effectiveness in helping Philadelphians attain higher education and marketable job skills. The study compares the college with three sets of similar institutions nationwide based on data from 2008 to 2013 and includes insights from the school's leaders, as well as local and…

  1. Actionable Intelligence about Early Childhood Risks in Philadelphia

    ERIC Educational Resources Information Center

    LeBoeuf, Whitney A.; Barghaus, Katherine; Fantuzzo, John; Coe, Kristen; Brumley, Benjamin

    2016-01-01

    "Early childhood risks" are markers of early childhood experiences that extensive research has shown to be detrimental to later academic and behavioral outcomes. In Philadelphia, evidence indicates that seven early childhood risks tracked by public agencies have negative effects on early school outcomes. These risks include low…

  2. Gratifications Lost: The 1985 Philadelphia Newspaper Strike and Media Use.

    ERIC Educational Resources Information Center

    Elliott, William R.; Rosenberg, William L.

    A study examined the relationship between newspaper gratifications sought and media use during and after a 1985 strike by unions of two Philadelphia newspapers, and the compensatory media behaviors, if any, people adopted to make up for the loss of their daily newspaper(s). It was hypothesized that during the strike, people would read more…

  3. Identity Performance and Collectivist Leadership in the Philadelphia Student Union

    ERIC Educational Resources Information Center

    Rosen, Sonia M.

    2016-01-01

    Youth organizing work benefits young people in myriad ways, equipping them with the skills and dispositions to organize around the systemic inequities and policy decisions that threaten their communities. The findings from this life histories study in the Philadelphia Student Union (PSU) reveal that the organization's collectivist leadership model…

  4. Philadelphia's Renaissance Schools Initiative: 18 Month Interim Report

    ERIC Educational Resources Information Center

    Gold, Eva; Norton, Michael H.; Good, Deborah; Levin, Stephanie

    2012-01-01

    This report presents Year One (2010-11) school level achievement and attendance outcomes and case study findings from fall 2011 that focused on school leadership and instruction. Thirteen schools were included in the first year of Philadelphia's Renaissance Schools Initiative (2010-11). Of these schools: (1) Four K-8 schools were…

  5. De Renatu Linguarum Antiquarum in Scholis Publicis Philadelphiae (On the Revival of Classical Languages in the Public Schools of Philadelphia)

    ERIC Educational Resources Information Center

    Masciantonio, Rudolph

    1977-01-01

    The enrollment in Latin and Greek classes in the Philadelphia public schools has increased greatly in the last ten years. Courses are offered in elementary as well as secondary schools. An audiolingual approach is used. Available from Universitaet des Saarlandes, Fachbereich 6.2, D-6600 Saarbrueken, West Germany. (Text is in Latin.) (CFM)

  6. Demonstration Assessment of LED Roadway Lighting: Philadelphia, PA

    SciTech Connect

    Royer, Michael P.; Tuenge, Jason R.; Poplawski, Michael E.

    2012-09-01

    For this demonstration assessment, 10 different groups of LED luminaires were installed at three sites in Philadelphia, PA. Each of the three sites represented a different set of conditions, most importantly with regard to the incumbent HPS luminaires, which were nominally 100 W, 150 W, and 250 W. The performance of each product was evaluated based on manufacturer data, illuminance calculations, field measurements of illuminance, and the subjective impressions of both regular and expert observers.

  7. The Recovery Act is "Lighting Up" the streets of Philadelphia

    ScienceCinema

    Nutter, Michael; Gajewski, Katherine; Russell, Toby; Williams, Doug; Best, DeLain

    2016-07-12

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. The project will use approximately $3 million in EECBG funds, matched with $3 million in PECO funding, and will save the city approximately $1 million in electric costs each year. For more information on Recovery Act projects funded by the Department of Energy in Pennsylvania: http://www.energy.gov/recovery/pa.htm

  8. The Recovery Act is "Lighting Up" the streets of Philadelphia

    SciTech Connect

    Nutter, Michael; Gajewski, Katherine; Russell, Toby; Williams, Doug; Best, DeLain

    2010-01-01

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. The project will use approximately $3 million in EECBG funds, matched with $3 million in PECO funding, and will save the city approximately $1 million in electric costs each year. For more information on Recovery Act projects funded by the Department of Energy in Pennsylvania: http://www.energy.gov/recovery/pa.htm

  9. Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia

    PubMed Central

    Armas, Aristides; Chen, Chen; Mims, Martha

    2017-01-01

    Myelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic alteration remains unclear. An uncommon chromosomic abnormality is the presence of the Philadelphia (Ph) chromosome. Here, we report a patient with Ph+ MDS treated with low dose Dasatinib who achieved hematologic response for 7 months. In addition, we also examined the English literature on all de novo Ph + MDS cases between 1996 and 2015 to gain insight into clinical features and outcome. PMID:28321349

  10. Establishing a Physics mentoring Program for a Philadelphia Middle School

    NASA Astrophysics Data System (ADS)

    Mlack, J. T.; Wilson, A.; Harris, W.; White, A.; Mehta, S. S.; Ramdass, V.

    2010-03-01

    Our SPS chapter has established a regular physics mentoring program at Independence Charter Middle School located in Philadelphia, PA. Members visit the school on a bi-weekly basis and perform 1-2 hour, inquiry-based lecture demonstrations of physics phenomena that integrate with the science lessons of middle school students. At the end of the school year, a capstone activity in the form of a Rube Goldberg competition among the middle school students was held on the Drexel campus with Drexel faculty and graduate students participating as judges.

  11. Urban ecosystem services and decision making for a green Philadelphia

    USGS Publications Warehouse

    Hogan, Dianna M.; Shapiro, Carl D.; Karp, David N.; Wachter, Susan M.

    2014-01-01

    Traditional approaches to urban development often do not account for, or recognize, the role of ecosystem services and the benefits these services provide to the health and well-being of city residents. Without such accounting, urban ecosystem services are likely to be degraded over time, with negative consequences for the sustainability of cities and the well-being of their residents (Millennium Ecosystem Assessment, 2005; Hirsch, 2008). On May 23, 2013, the Spatial Integration Laboratory for Urban Systems (SILUS), a collaboration between the U.S. Geological Survey (USGS) Science and Decisions Center and the Wharton GIS Lab, convened a one-day symposium—Urban Ecosystem Services and Decision Making: A Green Philadelphia—at the University of Pennsylvania in Philadelphia, Pennsylvania, to examine the role of green infrastructure in the environmental, economic, and social well-being of cities. Cosponsored by the USGS and the Penn Institute for Urban Research (Penn IUR), the symposium brought together policymakers, practitioners, and researchers from a range of disciplines to advance a research agenda on the use of science in public decision making to inform investment in green infrastructure and ecosystem services in urban areas. The city of Philadelphia has recently implemented a program designed to sustain urban ecosystem services and advance the use of green infrastructure. In 2009, the Philadelphia Mayor’s Office of Sustainability launched its Greenworks plan, establishing a citywide sustainability strategy. Major contributions towards its goals are being implemented in coordination with the Philadelphia Water Department (PWD). The Green City, Clean Waters initiative, the city’s nationally recognized stormwater management plan, was signed into action with the U.S. Environmental Protection Agency (EPA) in April 2012. The plan outlines a 25-year strategy to use green infrastructure to protect and improve the city’s watershed. Widespread support for the

  12. How Students Are Leading Us: Youth Organizing and the Fight for Public Education in Philadelphia

    ERIC Educational Resources Information Center

    Conner, Jerusha; Rosen, Sonia

    2013-01-01

    Philadelphia has a rich history of high school student activism, stretching back to 1967, when 3,500 Philadelphia students walked out of their schools, marched to the Board of Education, and demanded the addition of black history courses taught by black teachers, the removal of police from high schools, and an increase in the hiring of black…

  13. 33 CFR 165.T05-0511 - Safety Zone, Delaware River; Philadelphia, PA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...; Philadelphia, PA. 165.T05-0511 Section 165.T05-0511 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF...-0511 Safety Zone, Delaware River; Philadelphia, PA. (a) Location. The following area is a safety zone: All waters of the Delaware River in Chester, PA, inside a boundary encompassing all waters just...

  14. 75 FR 80568 - Proposed Modification of the Philadelphia, PA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ..., PA. The name and phone number of the person to contact for further information has changed from that... Philadelphia, PA (75 FR 74127). The name and phone number of the person to contact for further information has... following correction: FOR FURTHER INFORMATION CONTACT: Dennis Sweeney, Philadelphia ATCT/ TRACON, 15...

  15. A Tale of Two Cities: School Privatization in Philadelphia and Chester

    ERIC Educational Resources Information Center

    Maranto, Robert

    2005-01-01

    In August 2001, the state-run Control Board for the Chester-Upland School District awarded control of nine of their 10 schools to Edison Schools, with little opposition. In contrast, nearby Philadelphia fought state efforts to privatize schools. Finally, on July 31, 2002, the joint state-city Philadelphia School Reform Commission partially…

  16. 78 FR 76779 - Proposed Modification of the Philadelphia, PA, Class B Airspace Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This action proposes to amend the description of Area G of the Philadelphia Class B airspace area to correct a design error that resulted in the Class B airspace being published 2.1 nautical miles (NM) larger on the southeast side of the area than intended. No other changes to the Philadelphia Class B airspace are being...

  17. Strengthening Career and Technical Education and 21st Century Skills in Philadelphia. Executive Summary

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2009

    2009-01-01

    In Spring 2007, the John S. and James L. Knight Foundation awarded funds to the Philadelphia Youth Network (PYN) to undertake an analysis of Career and Technical Education (CTE) in Philadelphia, and to make recommendations on how CTE and other forms of career-connected education could better align with high-wage/high-demand jobs in the regional…

  18. Addressing the Need for School Age Child Care: A Guide for Philadelphia Elementary School Principals.

    ERIC Educational Resources Information Center

    Mintzer, Janet L.

    The Delaware Valley Child Care Council (DVCCC) developed this booklet to help Philadelphia school principals plan and develop privately run after-school centers in their schools. First, an executive summary documents the need for school-age day care nationwide and in the Philadelphia area. Section I offers guidance on planning a school-age child…

  19. Philadelphia's Renaissance Schools: A Report on Start up and Early Implementation

    ERIC Educational Resources Information Center

    Gold, Eva; Good, Deborah; Robertson-Kraft, Claire; Callahan, M. Kate

    2011-01-01

    In April 2009, Superintendent Arlene Ackerman announced her reform plan for the School District of Philadelphia (the District)--"Imagine 2014". Among other major initiatives, "Imagine 2014" laid the groundwork for Philadelphia's Renaissance Schools Initiative. The Renaissance Initiative, set to enter its second year in 2011-12,…

  20. Grow Your Own School Leaders: A Case Study of Principal Development in Philadelphia Schools

    ERIC Educational Resources Information Center

    Urban Education Collaborative, 2010

    2010-01-01

    In 2004-05, the School District of Philadelphia (SDP) began a groundbreaking partnership with the Eli Broad Foundation to develop the Academy for Leadership in Philadelphia Schools (ALPS), one of several Broad-funded, alternative principal development programs initiated across the country. The ALPS effort was designed to respond to two challenges:…

  1. Philadelphia Youth Network Report for the Year Ending December 08: On the Map

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2008

    2008-01-01

    This year's annual report of Philadelphia Youth Network (PYN) celebrates the continuing expansion of opportunities for high-quality education and career preparation available to Philadelphia youth. These opportunities--offered by an ever-growing set of partners and program providers--are present in neighborhoods and communities all across the…

  2. Health assessment for Publicker Industries Philadelphia, Philadelphia County, Pennsylvania, Region 3. CERCLIS No. PAD981939200. Preliminary report

    SciTech Connect

    Not Available

    1990-09-12

    The Publicker Industries, Inc. (Publicker) site is on the U.S. Environmental Protection Agency's National Priorities List. Publicker is located in Philadelphia, Philadelphia County, Pennsylvania. About 3,500 persons reside within 1 mile of Publicker. The area surrounding Publicker is primarily industrial. Across the Delaware River in New Jersey, ground water is used by several community water systems to supply about 100,000 persons with potable water. Based on the information reviewed, the Agency for Toxic Substances and Disease Registry has concluded that this site is of public health concern because of the risk to human health resulting from possible fire or explosion at the site. This site is also a potential public health concern because of the risk to human health resulting from possible exposure to hazardous substances at concentrations that may result in adverse health effects. As noted in the Human Exposure Pathways Section, human exposure to organic chemical contaminants may occur via ingestion of, inhalation of, and dermal contact with soils, ground water, sediments, and air. Additional information is needed to evaluate more fully the releases, migration, and resulting levels of contaminants at points of potential human exposure.

  3. Mesoscale wetfall chemistry around Philadelphia during frontal storms

    NASA Astrophysics Data System (ADS)

    Patrinos, A. A. N.; Brown, R. M.

    Preliminary results from a mesoscale "acid rain" study are presented. The study concentrates on precipitation-event sampling at a network of ˜40 stations located between 20 km and 60 km from the city of Philadelphia, Pennsylvania, with the goal of establishing the contribution of local emissions to the total ionic wet deposition load and of determining the spatial variability of this deposition on the suburban-rural scale. Two storms associated with weak warm fronts and displaying similar meteorological features were sampled successfully. For the first, urban emissions appear to have significantly affected the deposition of several inorganic ionic species, most notably NO3- no effect was evident for the second storm. A possible explanation of the apparent contrast is given in terms of the weekday-weekend emissions variability. A sampling density of approximately one collector per 200 to 300 km² appears adequate for both storms.

  4. Learning From Philadelphia: Topographies of HIV/AIDS Media Assemblages.

    PubMed

    Cartwright, Lisa

    2016-01-01

    For this contribution to the special issue on "Mapping Queer Bioethics," the author employs an array of public health and popular media texts (especially Jonathan Demme's film Philadelphia) to challenge the construction and reconstruction of HIV-positive bodies as sites of bioethical concern. In outlining notions of "digital restoration," the author argues that there has been of late a remapping of the first decade of the HIV/AIDS pandemic through media projects assembled from archived materials. Accordingly, the author suggests that in the first decades of the 2000s, we have witnessed a media-archaeological turn, whereby old materials have been reassembled for commemorative purposes that oftentimes perform a reshaping of the topography of the first decade of the AIDS pandemic.

  5. Geophysical investigation at Philadelphia Naval Shipyard. Final report,

    SciTech Connect

    Sharp, M.K.

    1992-03-01

    Results of a geophysical investigation at the incinerator site of Philadelphia Naval Shipyard are presented. Following the end of World War II, 50 to 60 pallets of gas cylinders were reportedly buried to the west of the old incinerator at Girard Point. The contents of the cylinders are unknown. Extensive filling operations occurred at Girard Point from 1940 to 1970, resulting in shallow groundwater surface in the area, 2 to 10 ft deep, which would indicate that the cylinders are probably in direct contact with the water surface. The geophysical investigation presented in this report was designed to help alleviate uncertainties produced from previous studies in the area. The geophysical program included electromagnetic induction and magnetic survey methods. The results of the various surveys were integrated, and numerous anomalous areas were interpreted. Anomalies warranting further investigation were presented along with a priority ranking.

  6. Reverse engineering course at Philadelphia University in Jordan

    NASA Astrophysics Data System (ADS)

    Bani Younis, M.; Tutunji, T.

    2012-03-01

    Reverse engineering (RE) is the process of testing and analysing a system or a device in order to identify, understand and document its functionality. RE is an efficient tool in industrial benchmarking where competitors' products are dissected and evaluated for performance and costs. RE can play an important role in the re-configuration and redesign of legacy and/or undocumented systems. It can also play a key role in helping students understand engineering products. This paper presents the Philadelphia University experience in constructing a RE course and integrating it within the engineering curricula. This paper can be used as a guide to other universities that wish to introduce RE to their curricula. The information provided in this paper covers the RE methodology for a system level, as well as mechanical, electronics and software levels. Finally, samples of student projects are presented in order to show the learning capabilities provided throughout the course.

  7. Temperature of ground water at Philadelphia, Pennsylvania, 1979- 1981

    USGS Publications Warehouse

    Paulachok, Gary N.

    1986-01-01

    Anthropogenic heat production has undoubtedly caused increased ground-water temperatures in many parts of Philadelphia, Pennsylvania, as shown by temperatures of 98 samples and logs of 40 wells measured during 1979-81. Most sample temperatures were higher than 12.6 degrees Celsius (the local mean annual air temperature), and many logs depict cooling trends with depth (anomalous gradients). Heating of surface and shallow-subsurface materials has likely caused the elevated temperatures and anomalous gradients. Solar radiation on widespread concrete and asphalt surfaces, fossil-fuel combustion, and radiant losses from buried pipelines containing steam and process chemicals are believed to be the chief sources of heat. Some heat from these and other sources is transferred to deeper zones, mainly by conduction. Temperatures in densely urbanized areas are commonly highest directly beneath the land surface and decrease progressively with depth. Temperatures in sparsely urbanized areas generally follow the natural geothermal gradient and increase downward at about that same rate.

  8. Using Local History To Understand National Themes: The Yellow Fever Epidemic in Philadelphia in 1793.

    ERIC Educational Resources Information Center

    Westbury, Susan

    2003-01-01

    Provides background information for a local history project about the 1793 Philadelphia (Pennsylvania) yellow fever outbreak. Offers potential project topics to help students learn about local history and understand life in the eighteenth century United States. (CMK)

  9. Whole-House Solutions for Existing Homes: Philadelphia Housing Authority Energy-Efficiency Turnover Protocols

    SciTech Connect

    2016-02-24

    The Philadelphia Housing Authority worked with the U.S. Department of Energy’s Building America Program to integrate energy-efficiency measures into the refurbishment process that each unit normally goes through between occupancies.

  10. The origins of American physical anthropology in Philadelphia.

    PubMed

    Mann, Alan

    2009-01-01

    With its location on a river with easy access to the sea, its central placement between the English speaking colonies to the north and south and its trading connections with the western frontier, there were many reasons Philadelphia became one of the most important towns of prerevolutionary America. In the early 1770s, it was the site of the first meeting organized to deal with the perceived inequities of the British government toward the colonies. It was where Thomas Jefferson wrote much of the Declaration of Independence, whose soaring statements reflecting the Age of Enlightenment spoke of the equality of all men. It was to this debate, centered on just who was included in this declaration that the origins of physical anthropology in America can be traced. Notable men in the early phases of this disputation included Samuel Stanhope Smith and especially Samuel George Morton, considered the founder of American physical anthropology. The American School of Anthropology, which argued for the polygenic origins of human races was substantially founded on Morton's work. Recent accusations that Morton manipulated data to support his racist views would appear unfounded. The publication of The Origin of Species in 1859 and the issuing of the Emancipation Proclamation in 1862-63 effectively ended the earlier debates. By the time of the American Civil War, 1861-65, physical anthropology was beginning to explore other topics including growth and development and anthropometry.

  11. Geohydrology and ground-water resources of Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Paulachok, Gary N.

    1991-01-01

    The aquifers underlying the 134.6-square-mile city of Philadelphia are divided by the Fall Line into the unconsolidated aquifers (chiefly sand and gravel) of the Coastal Plain and the consolidated-rock aquifers (chiefly schist of the Wissahickon Formation) of the Piedmont. Ground water is present under confined and unconfined conditions. The principal units of the confined-aquifer system are the lower and middle sands of the Potomac-Raritan-Magothy aquifer system. The lower sand unit is the most productive aquifer in Philadelphia. The median yield of wells screened in the lower sand unit is 275 gal/min (gallons per minute), and yields of some wells are as high as 1,350 gal/min. The median specific capacity is 16 (gal/min)/ft (gallons per minute per foot of drawdown). The principal units of the unconsolidated unconfined-aquifer system are the upper sand unit of the Potomac-Raritan-Magothy aquifer system and the informally named Trenton gravel. The median yield of wells tapping these two undifferentiated units is 90 gal/min, and yields of some wells are as high as 1,370 gal/min. The median specific capacity is 12 (gal/min)/ft. The consolidated unconfined-aquifer system consists mainly of the Wissahickon Formation. The median yield of nondomestic wells that tap the Wissahickon Formation is 45 gal/min, and yields are as high as 350 gal/min. The median specific capacity is 0.5 (gal/min)/ft. Urbanization has considerably modified the hydrologic cycle in Philadelphia. Impervious surfaces have reduced recharge areas and evapotranspiration and have increased direct runoff. Leakage from the water-distribution system, which is supplied from the Delaware and Schuylkill Rivers, was about 60 to 72 Mgal/d (million gallons per day) in 1980. Groundwater infiltration to sewers is estimated to be as much as 135 Mgal/d when the water table is high. The potentiometric surface of the lower sand unit has been lowered substantially by pumping. By 1954, cones of depression were more than

  12. Philadelphia Electric Company's computer replacement lessons learned at Peach Bottom

    SciTech Connect

    Clark, J.M.; O'Hara, J.

    1989-01-01

    The current regulatory climate continues to prod today's nuclear utilities toward safer and more reliable operation of their plants. U.S. Nuclear Regulatory Commission guides NUREG-0660, NUREG-0696, and Supplement I to NUREG-0737 have all set forth increased requirements for plant monitoring. In response, the industry has looked at their existing plant computer systems as targets for enhancement or upgrade. This external pressure is nearly matched by the increasing demands made on existing computer systems by utility engineering and operations departments. The longer utilities postpone this evolution, the more likely they are to replace the entire system rather than upgrade the existing one. The older systems become harder to maintain and eventually are technically inferior to new systems, which have benefited from advances in computer technology in recent years. Enhancements become less economically advantageous than system replacements as the spread in technology widens. The object of this paper is to describe the Plant Process Computer Replacement Project at Philadelphia Electric Company's (PECo's) Peach Bottom Atomic Power Station. This paper explores (a) the impact on the plant, (b) the design and engineering services required, and (c) the planning and communication essential to a successful computer replacement project.

  13. "He Says You're Going To Play the Giant": Ethnographic Perspectives on a Cambodian Arts Class in Philadelphia. Philadelphia Folklore Project Working Papers #8.

    ERIC Educational Resources Information Center

    Westerman, William

    This project began when the Philadelphia Folklore Project (PFP) initiated a residency partnership with the Samuel S. Fleisher Art Memorial in traditional Cambodian arts. The PFP anticipated raising issues that might help in the understanding of the cultural dynamics and elements that were likely to shape and effect the residency. The PFP imagined…

  14. Modeling epilepsy disparities among ethnic groups in Philadelphia, PA

    PubMed Central

    Wheeler, David C.; Waller, Lance A.; Elliott, John O.

    2014-01-01

    SUMMARY The Centers for Disease Control and Prevention defined epilepsy as an emerging public health issue in a recent report and emphasized the importance of epilepsy studies in minorities and people of low socioeconomic status. Previous research has suggested that the incidence rate for epilepsy is positively associated with various measures of social and economic disadvantage. In response, we utilize hierarchical Bayesian models to analyze health disparities in epilepsy and seizure risks among multiple ethnicities in the city of Philadelphia, Pennsylvania. The goals of the analysis are to highlight any overall significant disparities in epilepsy risks between the populations of Caucasians, African Americans, and Hispanics in the study area during the years 2002–2004 and to visualize the spatial pattern of epilepsy risks by ethnicity to indicate where certain ethnic populations were most adversely affected by epilepsy within the study area. Results of the Bayesian model indicate that Hispanics have the highest epilepsy risk overall, followed by African Americans, and then Caucasians. There are significant increases in relative risk for both African Americans and Hispanics when compared with Caucasians, as indicated by the posterior mean estimates of 2.09 with a 95 per cent credible interval of (1.67, 2.62) for African Americans and 2.97 with a 95 per cent credible interval of (2.37, 3.71) for Hispanics. Results also demonstrate that using a Bayesian analysis in combination with geographic information system (GIS) technology can reveal spatial patterns in patient data and highlight areas of disparity in epilepsy risk among subgroups of the population. PMID:18381676

  15. Increased mortality in Philadelphia associated with daily air pollution concentrations.

    PubMed

    Schwartz, J; Dockery, D W

    1992-03-01

    Cause-specific deaths by day for the years 1973 to 1980 in Philadelphia, Pennsylvania, were extracted from National Center for Health Statistics mortality tapes. Death from accidents (International Classification of Disease, Revision 9 greater than or equal to 800) and deaths outside of the city were excluded. Daily counts of deaths were regressed using Poisson regression on total suspended particulate (TSP) and/or SO2 on the same day and on the preceding day, controlling for year, season, temperature, and humidity. A significant positive association was found between total mortality (mean of 48 deaths/day) and both TSP (second highest daily mean, 222 micrograms/m3) and SO2 (second highest daily mean, 299 micrograms/m3). The strongest associations were found with the mean pollution of the current and the preceding days. Total mortality was estimated to increase by 7% (95% CI, 4 to 10%) with each 100-micrograms/m3 increase in TSP, and 5% (95% CI, 3 to 7%) with each 100-micrograms/m3 increase in SO2. When both pollutants were considered simultaneously, the SO2 association was no longer significant. Mortality increased monotonically with TSP. The effect of 100 micrograms/m3 TSP was stronger in subjects older than 65 yr of age (10% increase) compared with those younger than 65 yr of age (3% increase). Cause-specific mortality was also associated with a 100-micrograms/m3 increase in TSP: chronic obstructive pulmonary disease (ICD9 490-496), +19% (95% CI, 0 to 42%), pneumonia (ICD9 480-486 & 507), +11% (95% CI, -3 to +27%), and cardiovascular disease (ICD9 390-448), +10% (95% CI, 6 to 14%). These results are somewhat higher than previously reported associations, and they add to the body of evidence showing that particulate pollution is associated with increased daily mortality at current levels in the United States.

  16. Reptile neoplasia at the Philadelphia Zoological Garden, 1901-2002.

    PubMed

    Sykes, John M; Trupkiewicz, John G

    2006-03-01

    A retrospective study of neoplasia in reptiles held at the Philadelphia Zoological Garden was conducted. A total of 3,684 original necropsy reports for the period 1901-2002 were reviewed and revealed 86 cases of neoplasia. Original glass slides or re-cuts from paraffin-embedded tissue blocks were examined for confirmation of the original diagnosis. At necropsy, a total of six neoplasms were identified in six of 490 chelonians (1.2%), 22 neoplasms in 19 of 736 lizards (3.0%), and 58 neoplasms in 53 of 1,835 snakes (2.9%). An additional 12 neoplasms were found in biopsies of one turtle and 10 snakes. In the chelonians, all the neoplasms were seen in turtles, four of six tumors were malignant (66%) and no organ predilection was noted. For lizards, the liver was the most commonly affected organ, with 7 of 22 primary neoplasms (31%). Multiple tumor types were identified in three lizards (15%), metastasis occurred in five cases (25%), and malignant tumors were identified in 16 cases (73%). In snakes, the liver was most frequently affected by neoplasia at necropsy, with 13 of 58 primary neoplasms (22%); multiple types of neoplasm were identified in five cases (10%) and metastasis in six (9%); and 42 tumors (80%) were diagnosed as malignant. When biopsies were included for snakes, however, the skin was the most commonly affected organ, with 17 of 69 neoplasms (24%). One of five lizards (20%) and four of six snakes (66%) with metastasis also had a second primary neoplasm. Since 1967, the incidence of lizard neoplasia has increased from 0.7% to 5.9%, and snake neoplasia has increased from 2.6% to 9.3%.

  17. Diversity of breakpoints of variant Philadelphia chromosomes in chronic myeloid leukemia in Brazilian patients

    PubMed Central

    Chauffaille, Maria de Lourdes Lopes Ferrari; Bandeira, Ana Carolina de Almeida; da Silva, Aline Schiavoni Guarnieri

    2014-01-01

    Background Chronic myeloid leukemia is a myeloproliferative disorder characterized by the Philadelphia chromosome or t(9;22)(q34.1;q11.2), resulting in the break-point cluster region-Abelson tyrosine kinase fusion gene, which encodes a constitutively active tyrosine kinase protein. The Philadelphia chromosome is detected by karyotyping in around 90% of chronic myeloid leukemia patients, but 5–10% may have variant types. Variant Philadelphia chromosomes are characterized by the involvement of another chromosome in addition to chromosome 9 or 22. It can be a simple type of variant when one other chromosome is involved, or complex, in which two or more chromosomes take part in the translocation. Few studies have reported the incidence of variant Philadelphia chromosomes or the breakpoints involved among Brazilian chronic myeloid leukemia patients. Objective The aim of this report is to describe the diversity of the variant Philadelphia chromosomes found and highlight some interesting breakpoint candidates for further studies. Methods the Cytogenetics Section Database was searched for all cases with diagnoses of chronic myeloid leukemia during a 12-year period and all the variant Philadelphia chromosomes were listed. Results Fifty (5.17%) cases out of 1071 Philadelphia-positive chronic myeloid leukemia were variants. The most frequently involved chromosome was 17, followed by chromosomes: 1, 20, 6, 11, 2, 10, 12 and 15. Conclusion Among all the breakpoints seen in this survey, six had previously been described: 11p15, 14q32, 15q11.2, 16p13.1, 17p13 and 17q21. The fact that some regions get more frequently involved in such rare rearrangements calls attention to possible predisposition that should be further studied. Nevertheless, the pathological implication of these variants remains unclear. PMID:25638762

  18. Perspective: Academic obstetrics-gynecology departments in the city of Philadelphia: are the wheels coming off?

    PubMed

    Croft, Damien J

    2011-03-01

    Maternity care in Philadelphia is in an unprecedented and precarious situation, as all the community hospitals that once provided maternity care services have either closed completely or stopped providing maternity services. Six academic medical centers (AMCs) in the city of Philadelphia now provide care to a population of 1.5 million requiring increasingly complex and expensive maternity care, at the same time as insurance premiums and the malpractice crisis in Pennsylvania peaked. The AMCs are able to continue providing maternity care to this population that includes a large proportion of poor, minority, and un- or underinsured patients thanks to government subsidization of resident education, the services provided by resident physicians, and the influx of government and industry research funds, but the financial outlook of academic obstetrics-gynecology departments in this city is dire. Obstetric academic medicine in Philadelphia has come to more closely resemble a "big wheel" tricycle than Flexner's "three-legged stool." Clinical medicine is the driver (the large front wheel and pedal) pulling along education and research, the two smaller wheels in the back. A maternity care alliance is needed in Philadelphia allowing area AMCs to pool and trade resources, reduce costs, improve quality and innovation, and share risks. Philadelphia may serve as an early warning for other cities and AMCs around the country and has the opportunity to serve as a model for how to overcome these serious challenges.

  19. Philadelphia obtains useful information from its customers about taste and odour quality.

    PubMed

    Burlingame, G A; Mackey, E D

    2007-01-01

    Customers are sensitive to the flavour of water. Customers evaluate drinking water based on their expectations, on experiences with their usual drinking water and on experiences with alternative waters. The Philadelphia Water Department provides one example of success in developing a better understanding of customer perceptions and attitudes about tap water taste and odour. Philadelphia found that customers do communicate in ways that water utilities can understand. Water utilities can enhance that communication and collect useful data. In addition, water utilities can characterise their tap water flavour, track it for changes and correlate changes to customer complaints.

  20. Un-Leaded Only: Toward a Safer City for Children. A 2002 Report on Childhood Lead Paint Poisoning in Philadelphia.

    ERIC Educational Resources Information Center

    McCauley, Colleen; Yanoff, Shelly D.; Fynes, Steven E.

    As part of its work in improving the lives and life changes of children in the Philadelphia region, the Philadelphia Citizens for Children and Youth examined the problem of local childhood lead paint poisoning. This report describes their efforts, beginning with a description of the impact of lead poisoning on children's health and a discussion of…

  1. Student Achievement in Privately Managed and District-Managed Schools in Philadelphia Since the State Takeover. Research Brief

    ERIC Educational Resources Information Center

    Gill, Brian; Zimmer, Ron; Christman, Jolley; Blanc, Suzanne

    2007-01-01

    Following a state takeover of the Philadelphia public schools in 2002, 45 schools were turned over to private managers, making Philadelphia the site of the nation's largest experiment in the private management of public schools. This study examines achievement effects in the privately managed schools, as well as in schools with district-led…

  2. 40 CFR 52.2053 - The Motor Vehicle Emissions Budgets for the Pennsylvania Counties in the Philadelphia-Wilmington...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the Pennsylvania Counties in the Philadelphia-Wilmington, PA-NJ-DE 1997 Fine Particulate Matter...-Wilmington, PA-NJ-DE 1997 Fine Particulate Matter Nonattainment Area As of April 3, 2013, EPA approves the... nitrogen oxides (NOX) for the Pennsylvania Counties in the Philadelphia-Wilmington, PA-NJ-DE 1997...

  3. 40 CFR 52.2053 - The Motor Vehicle Emissions Budgets for the Pennsylvania Counties in the Philadelphia-Wilmington...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Pennsylvania Counties in the Philadelphia-Wilmington, PA-NJ-DE 1997 Fine Particulate Matter...-Wilmington, PA-NJ-DE 1997 Fine Particulate Matter Nonattainment Area As of April 3, 2013, EPA approves the... nitrogen oxides (NOX) for the Pennsylvania Counties in the Philadelphia-Wilmington, PA-NJ-DE 1997...

  4. ASSOCIATIONS BETWEEN PARTICULATE MATTER COMPONENTS AND DAILY MORTALITY AND MORBIDITY IN PHILADELPHIA, PA

    EPA Science Inventory

    In evaluating the health risks from particulate matter (PM), the question remains as to which component(s) of PM are most harmful. We investigated this issue using PM mass, PM constituents, mortality, and the elderly hospital admission data in Philadelphia, PA. Daily paired PM...

  5. Contracting Out Schools: The First Year of the Philadelphia Diverse Provider Model

    ERIC Educational Resources Information Center

    Bulkley, Katrina; Mundell, Leah; Riffer, Morgan

    2004-01-01

    Educators nationwide focused on Philadelphia in the summer of 2001 as politicians and policy makers explored the possibility of a state takeover of the city's school system, a seismic power shift that would produce the largest privatization of a public school district in American history. The findings reported in this document are based on…

  6. Characteristics of English Language Learners in the School District of Philadelphia. PERC Research Brief

    ERIC Educational Resources Information Center

    Lin, Joshua; Hughes, Rosemary; Long, Daniel; Kim, Dae

    2016-01-01

    As a group, English Language Learners (ELLs) are diverse and come from a variety of home languages, cultures, educational backgrounds, and educational needs. This brief focuses on descriptive characteristics of the ELL students served by the School District of Philadelphia in 2014-2015. Specifically, this brief highlights the diversity of the ELL…

  7. Elements of Success: WorkReady Philadelphia Program Year 2011-2012 Report

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2012

    2012-01-01

    What does it take to deliver WorkReady Philadelphia's high-quality career-connected programming? In short, it's all about the "elements"--those essential components of the system that combine to produce success for young people. This 2011-12 WorkReady report reinforces this theme by using visual aspects of the "Periodic Table of…

  8. Extension, Communities, and Schools: Results of a Collaborative Forestry Education Project in Philadelphia.

    ERIC Educational Resources Information Center

    Broussard, Shorna R.; Jones, Stephen B.

    2001-01-01

    Penn State Extension, Philadelphia community leaders, school district administrators, and teachers developed a comprehensive program to teach inner-city youth about forestry and forest management. Evaluation results indicate that students were more knowledgeable about forestry and forest management; teachers were more likely to use natural…

  9. PM CONSTITUENT ROLES IN MASS ASSOCIATIONS WITH HEALTH EFFECTS IN PHILADELPHIA, PA

    EPA Science Inventory

    An environmental and health database was constructed for Philadelphia, PA for the period 1992-1995 in order to assess the importance of PM components in mass associations with adverse health effects. PM data were collected by Harvard University for the U.S. EPA. Daily measureme...

  10. Spatial analysis of volatile organic compounds in South Philadelphia using passive samplers

    EPA Science Inventory

    Select volatile organic compounds (VOCs) were measured in the vicinity of a petroleum refinery and related operations in South Philadelphia, Pennsylvania, USA, using passive air sampling and laboratory analysis methods. Two-week, time-integrated samplers were deployed at 17 sites...

  11. 75 FR 25285 - John Heinz National Wildlife Refuge at Tinicum, Philadelphia and Delaware Counties, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... comprehensive conservation plan and environmental assessment; request for comments. SUMMARY: We, the U.S. Fish... environmental assessment (EA) for John Heinz National Wildlife Refuge (NWR) at Tinicum in Philadelphia... issues to consider in the environmental document and during development of the CCP. Background The...

  12. Learn at Home: A Philadelphia Distance Learning Project. Program Year 1992-1993. Final Report.

    ERIC Educational Resources Information Center

    Cooper, Donna

    The Power Learning Project was a pilot test of the potential of home-based computer-assisted instruction (CAI) for adults with intermediate reading skills and adult nonnative speakers of English. Project development was made possible by a partnership involving public, private, and community-based organizations in Philadelphia. Online services were…

  13. A Philadelphia Story: Building Civic Capacity for School Reform in a Privatizing System

    ERIC Educational Resources Information Center

    Gold, Eva; Simon, Elaine; Cucchiara, Maia; Mitchell, Cecily; Riffer, Morgan

    2007-01-01

    This report was undertaken to assess the state of civic capacity for education reform in Philadelphia. It challenges community and civic sectors of the city to put aside individual interests and work together to mobilize resources to pursue the collective good of public school improvement. The report demonstrates that many of the elements…

  14. Osage Avenue Is Burning: The Influence of Race upon Crisis Public Relations in Philadelphia.

    ERIC Educational Resources Information Center

    Bishop, Robert L.; Boles, Wendy Gotchel

    A study examined public relations aspects of the police confrontation and bombing of the revolutionary Black group, MOVE, in Philadelphia, in which 11 persons were killed, 250 were left homeless, and 61 homes were destroyed. It explored if and how race affected the crisis and whether Black media and general media were treated differently. City…

  15. Environmental Investigation and Risk Assessment. Phase 1 Report Tacony Warehouse, Philadelphia, Pennsylvania

    DTIC Science & Technology

    1993-08-24

    Sayreville sand, the middle clay, the Old Bridge sand, and the upper clay. The Raritan is overlain in adjacent parts of New Jersey by the Magothy ...Formation, but the Magothy Formation has not been identified in the Philadelphia area. The sediments that overlie the Raritan are Pleistocene deposits...Qc,Pleistocene -.-- Unconjormity ... so Pensauken formation , Qp (Illinoian) Unconformitg . . . Magothy formation Kn 10 ... Uncontormity .... Upper

  16. You "Can" Get There from Here: 2009 and 2010 Philadelphia Youth Network Annual Report

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2010

    2010-01-01

    This paper presents the annual report of Philadelphia Youth Network (PYN) for 2009-2010. This annual report documents the journeys of several participants in their programs who have gone on successfully to college and careers, and demonstrates the potential of young Philadelphians to begin to reach their goals. In telling these stories, they build…

  17. History, Heritage, and Hearsay: A Children's Guide to Ethnic South and Southwest Philadelphia.

    ERIC Educational Resources Information Center

    D'Amico, Joseph J.; Newcombe, Ellen

    This guide for elementary students will help them learn about five of South and Southwest Philadelphia's ethnic groups and examine their own ethnic heritage. These groups are: Afro Americans, Irish Americans, Italian Americans, Jewish Americans, and Polish Americans. The guide has different sections. "Hearsay" sections contain short…

  18. Seizing Opportunities: Genie Tyburski--Ballard Spahr Andrews & Ingersoll, LLP, Philadelphia

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    Genie Tyburski did not set out to be a law librarian. When asked at Drexel's library school what kind of librarian she wanted to be, she was surprised that "a good one" was not one of the options. But six weeks into the semester, she landed a part-time cataloging job at Community Legal Services in Philadelphia; six months later she was…

  19. Unfulfilled Promise: The Dimensions and Characteristics of Philadelphia's Dropout Crisis, 2000-2005

    ERIC Educational Resources Information Center

    Neild, Ruth Curran; Balfanz, Robert

    2006-01-01

    This report uses a unique set of data obtained from the Kids Integrated Data System (KIDS), which is housed at the University of Pennsylvania's Cartographic Modeling Laboratory. The KIDS system merges individual-level data on young people from the School District of Philadelphia and the city's social service agencies, including the Department of…

  20. Getting a Feel for the Market: The Use of Privatized School Management in Philadelphia

    ERIC Educational Resources Information Center

    Byrnes, Vaughan

    2009-01-01

    This study evaluates the impact of the privatization of education services in the Philadelphia School District, using an interrupted time series design. The sample observes 88 middle-grades schools, beginning with the 1996-97 school year, and finds that, by 2006, four years postintervention, the achievement growth rate of schools run by…

  1. Public Education in Philadelphia: The Crucial Need for Civic Capacity in a Privatized Environment

    ERIC Educational Resources Information Center

    Blanc, Suzanne; Simon, Elaine

    2007-01-01

    Like many other U.S. cities, Philadelphia experienced a prolonged period of deindustrialization and job loss during the second half of the 20th century. As in other northern cities, the process of suburbanization went hand in hand with white flight, increased racial segregation of the city and its schools, and increasingly inadequate funding of…

  2. Philadelphia's Talent Development High Schools: Second-Year Results, 2000-01.

    ERIC Educational Resources Information Center

    Useem, Elizabeth; Neild, Ruth Curran; Morrison, William

    Philadelphia, Pennsylvania's Talent Development High School comprehensive reform model addresses low student achievement and poor school climate, blending a common core academic curriculum with career themes in the upper grades. It includes a separate Ninth Grade Success Academy with interdisciplinary teacher teams, ninth and tenth grade Career…

  3. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Exception for New York and Philadelphia. 37.53 Section 37.53 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and...

  4. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Exception for New York and Philadelphia. 37.53 Section 37.53 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and...

  5. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Exception for New York and Philadelphia. 37.53 Section 37.53 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and...

  6. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Exception for New York and Philadelphia. 37.53 Section 37.53 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and...

  7. 78 FR 75902 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Philadelphia County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-13

    ...-- Delaware Station; (2) Exelon--Richmond Station; (3) Exelon--Schuylkill Station; (4) Veolia--Edison Station... ozone standard for Philadelphia County pursuant to section 110(k)(4) of the CAA. Additional details on... Company); (8) Temple University, Health Sciences Center; (9) GATX Terminals Corporation; and...

  8. WWC Review of the Report "Philadelphia's Renaissance Schools Initiative: 18 Month Interim Report"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The study reviewed in this report examined the effects of Philadelphia's "Renaissance Schools Initiative" on students in K-8 schools after one year of implementation. Schools were selected for participation based on their School Performance Index (SPI) at the start of the 2010-11 school year. The SPI rates every school in Philadelphia…

  9. What Works Clearinghouse Quick Review: "Philadelphia's Renaissance Schools Initiative: 18 Month Interim Report"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The study examined the effectiveness of Philadelphia's Renaissance Schools Initiative after one year of implementation. The Renaissance Schools Initiative, which began in the 2010-11 school year, aimed at improving low-performing schools by providing new management, additional resources, and new educational strategies. The study reported that…

  10. Blurring the Boundaries: A Case Study of Private Sector Involvement in Philadelphia Public Schools

    ERIC Educational Resources Information Center

    Gold, Eva; Christman, Jolley Bruce; Herold, Benjamin

    2007-01-01

    As a result of a state takeover, the School District of Philadelphia has been implementing a "diverse provider model" in which for-profit and nonprofit organizations have been hired as school managers. This study explores the first three years of the model, examining the shift away from the rhetoric of competition to the evolution of a…

  11. "Welcome to Philadelphia": An Original Dramatization of Life in the 1780s.

    ERIC Educational Resources Information Center

    Stakes, Mary E.

    Teachers can create an interest in the founding period of U.S. history and present students with an authentic view of this time period through the presentation of this play. The dramatic pretense of the play is that the audience, by their presence, is part of the drama. The audience plays the part of travelers visiting a Philadelphia home in the…

  12. Uneven Playing Field: Demographic Differences and High School "Choice" in Philadelphia. Policy Brief

    ERIC Educational Resources Information Center

    Research for Action, 2010

    2010-01-01

    Every fall, eighth graders participate in the School District of Philadelphia's high school application and admissions process, vying for spots in a tiered system of public high schools across the city. This policy brief looks at disparities in the students who are successful in exercising school "choice" in the District's high school…

  13. Parents' "Hard" Knowledge of Admission Criteria and Acceptance in Philadelphia's High School Choice Process

    ERIC Educational Resources Information Center

    Haxton, Clarisse L.; Neild, Ruth Curran

    2012-01-01

    We examine parents' knowledge of discrete, verifiable facts--what we call "hard knowledge"--in a high school application process. Using parent survey data (n = 658) from the School District of Philadelphia, this study examines whether parents knew the admission criteria and acceptance rate at the high school they most wanted their child…

  14. The Launch of the Philadelphia Education Research Consortium: Lessons Learned from the First Year of Implementation

    ERIC Educational Resources Information Center

    Shaw, Kate

    2016-01-01

    The Philadelphia Education Research Consortium (PERC) was launched in July 2014 as an innovative place-based consortium of educational research partners from multiple sectors. Its primary objective is to provide research and analyses on some of the city's most pressing education issues. As such, PERC's research agenda is driven by both traditional…

  15. The Efficacy of Philadelphia's K-to-8 Schools Compared to Middle Grades Schools.

    ERIC Educational Resources Information Center

    Offenberg, Robert M.

    2001-01-01

    Natural experiments explored the effects of attending public Philadelphia K-to-8 schools or public middle schools on eighth- and ninth-grade achievement. Found that students attending K-8 schools had higher reading, mathematics, and science achievement than students attending middle schools serving similar communities. Suggested that number of…

  16. Sowing City Schools: Teachers and Garden Education in Havana and Philadelphia

    ERIC Educational Resources Information Center

    Bucher, Katie Ann

    2012-01-01

    This dissertation examines how pedagogies of sustainability are embedded in socio-cultural contexts and policy structures and driven by the localized actions of teachers. Through a comparative case study in two cities with extensive and varied school garden programs, Havana and Philadelphia, this dissertation analyzes the roles, understandings,…

  17. 78 FR 3482 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of Proposed Rule Change With Respect to the Amendment of the By-Laws of Its Parent Corporation, The NASDAQ...

  18. Reproducibility of the WHO histological criteria for the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms.

    PubMed

    Gianelli, Umberto; Bossi, Anna; Cortinovis, Ivan; Sabattini, Elena; Tripodo, Claudio; Boveri, Emanuela; Moro, Alessia; Valli, Riccardo; Ponzoni, Maurilio; M Florena, Ada; F Orcioni, Giulio; Ascani, Stefano; Bonoldi, Emanuela; Iurlo, Alessandra; Gugliotta, Luigi; Franco, Vito

    2014-06-01

    This study, performed on behalf of the Italian Registry of Thrombocythaemias (Registro Italiano Trombocitemie), aimed to test the inter-observer reproducibility of the histological parameters proposed by the WHO classification for the diagnosis of the Philadelphia chromosome-negative myeloproliferative neoplasms. A series of 103 bone marrow biopsy samples of Philadelphia chromosome-negative myeloproliferative neoplasms consecutively collected in 2004 were classified according to the WHO criteria as follows: essential thrombocythaemia (n=34), primary myelofibrosis (n=44) and polycythaemia vera (n=25). Two independent groups of pathologists reviewed the bone marrow biopsies. The first group was asked to reach a collegial 'consensus' diagnosis. The second group reviewed individually all the cases to recognize the main morphological parameters indicated by the WHO classification and report their results in a database. They were subsequently instructed to individually build a 'personal' diagnosis of myeloproliferative neoplasms subtype just assembling the parameters collected in the database. Our results indicate that high levels of agreement (≥70%) have been reached for about all of the morphological features. Moreover, among the 18 evaluated histological features, 11 resulted statistically more useful for the differential diagnosis among the different Philadelphia chromosome-negative myeloproliferative neoplasms. Finally, we found a high percentage of agreement (76%) between the 'personal' and 'consensus' diagnosis (Cohen's kappa statistic >0.40). In conclusion, our results support the use of the histological criteria proposed by the WHO classification for the Philadelphia chromosome-negative myeloproliferative neoplasms to ensure a more precise and early diagnosis for these patients.

  19. Educating English Language Learners: Instructional Approaches and Teacher Collaboration in Philadelphia Public Schools. PERC Research Brief

    ERIC Educational Resources Information Center

    Reumann-Moore, Rebecca; Rowland, Jeannette; Hughes, Rosemary; Lin, Joshua

    2016-01-01

    Districts, charter management organizations, and individual schools can learn a great deal from each other about strategies for creating robust and supportive learning environments for English Language Learners (ELLS). This brief highlights key findings about how Philadelphia public schools were crafting instructional approaches to serve their…

  20. Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia

    SciTech Connect

    Rubin, C.M.; Carrino, J.J.; Dickler, M.N.; Leibowitz, D.; Smith, S.D.; Westbrook, C.A.

    1988-04-01

    Philadelphia chromosome-positive acute lymphoblastic leukemia occurs in two molecular forms, those with and those without rearrangement of the breakpoint cluster region on chromosome 22. The molecular abnormality in the former group is similar to that found in chronic myelogenous leukemia. To characterize the abnormality in the breakpoint cluster region-unrearranged form, the authors have mapped a 9; 22 translocation from the Philadelphia chromosome-positive acute lymphoblastic leukemia cell line SUP-B13 by using pulsed-field gel electrophoresis and have cloned the DNA at the translocation junctions. They demonstrate a BCR-ABL fusion gene on the Philadelphia chromosome. The exons from ABL are the same. Analysis of leukemic cells from four other patients with breakpoint cluster region-unrearranged Philadelphia chromosome-positive acute lymphoblastic leukemia revealed a rearrangement on chromosome 22 close to the breakpoint in SUP-B13 in only one patient. These data indicate that breakpoints do not cluster tightly in this region but are scattered, possibly in a large intron. Given the large size of BCR and the heterogeneity in breakpoint location, detection of BCR rearrangement by standard Southern blot analysis is difficult. Pulsed-field gel electrophoresis should allow detection at the DNA level in every patient and thus will permit clinical correlation of the breakpoint location with prognosis.

  1. What Love Can Do: A Brief History of Quaker Education in Philadelphia.

    ERIC Educational Resources Information Center

    Kashatus, William C., III

    1994-01-01

    William Penn understood that many colonial settlers would not be members of the Religious Society of Friends, so he tried to ensure the practice of Quaker ideals by establishing a compulsory, universal school system embodying the values of community, equality, pacifism, and simplicity. After 300 years, the Philadelphia Yearly Meeting's Committee…

  2. What Next?: Educational Innovation and Philadelphia's School of the Future. Educational Innovations Series

    ERIC Educational Resources Information Center

    Cullinane, Mary, Ed.; Hess, Frederick M., Ed.

    2010-01-01

    "What Next?" offers a detailed study of the School of the Future's first three years (2006-2009) revealing what the School of the Future can teach us about high school redesign, public-private partnerships, and the use of technology in school reform. When the school district of Philadelphia teamed up with the Microsoft Corporation in…

  3. 49 CFR 37.53 - Exception for New York and Philadelphia.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Exception for New York and Philadelphia. 37.53 Section 37.53 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.53 Exception for New York and...

  4. SEASONAL ABUNDANCE OF ORGANIC MOLECULAR MARKERS IN URBAN PARTICULATE MATTER FROM PHILADELPHIA, PA

    EPA Science Inventory

    Organic molecular markers were measured in airborne particulate matter (PM10) from the City of Philadelphia North Broad Street air quality monitoring site to identify the seasonal abundances of key tracer compounds together with their dominant sources. Daily PM10...

  5. QUANTITATION, DETECTION AND MEASUREMENT PRECISION OF ORGANIC MOLECULAR MARKERS IN URBAN PARTICULATE MATTER FROM PHILADELPHIA, PA

    EPA Science Inventory

    This work focuses on analysis of organic molecular markers in airborne particulate matter (PM) by Gas Chromatography/Ion Trap Mass Spectrometry (GC/IT MS). The particulate samples used in the method development were collected as PM10 in metropolitan Philadelphia during...

  6. Powerful Ideas, Modest Gains: Five Years of Systemic Reform in Philadelphia Middle Schools.

    ERIC Educational Resources Information Center

    Christman, Jolley Bruce

    This report details what happened in Philadelphia's middle schools during the Children Achieving reform effort, a comprehensive, one-size-fits-all reform project. Based on research of the program over a 5-year period, the paper explains why reforms fell short of their intended outcomes. The critical levers for change were content standards, the…

  7. Development and Simulation Testing of a Computerized Adaptive Version of the Philadelphia Naming Test

    ERIC Educational Resources Information Center

    Hula, William D.; Kellough, Stacey; Fergadiotis, Gerasimos

    2015-01-01

    Purpose: The purpose of this study was to develop a computerized adaptive test (CAT) version of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996), to reduce test length while maximizing measurement precision. This article is a direct extension of a companion article (Fergadiotis, Kellough, & Hula, 2015),…

  8. The Workshop and the Classroom: Philadelphia Engineering, the Decline of Apprenticeship, and the Rise of Industrial Training, 1878-1900.

    ERIC Educational Resources Information Center

    Dawson, Andrew

    1999-01-01

    Addresses the change from the system of workshop apprenticeship to that of industrial training, pioneered in 1878 by the Baldwin Locomotive Works and the Spring Garden Institute, that eventually spread to the public school system in Philadelphia (Pennsylvania). (CMK)

  9. Acute, fatal Sarcocystis calchasi-associated hepatitis in Roller pigeons (Columbia livia f. dom.) at Philadelphia Zoo

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Four Roller pigeons (Columba livia f. dom.) at the Philadelphia Zoo died suddenly. Necropsy examination revealed macroscopic hepatitis. Microscopically, the predominant lesions were in liver, characterized with necrosis and mixed cell inflammatory response. Sarcocystis calchasi-like schizonts and fr...

  10. Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review

    PubMed Central

    SHEN, ZHENG-LEI; YIN, LIE-FEN; MAO, WEN-WEN; LIANG, JIN; YANG, LING

    2016-01-01

    The current study reports the case of a patient with Philadelphia chromosome-negative (Ph−) non-Hodgkin's lymphoma (NHL) and chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) that also possessed characteristic enlarged lymph nodes. A lymph node biopsy resulted in the diagnosis of CP-CML, in addition to T-lymphoblastic cell NHL with negative break point cluster/Abelson tyrosine kinase fusion genes in the lymph node of the patient, which was diagnosed as Ph− NHL. A review of the literature was performed in the present study to investigate the genetic differences between Ph− NHL and Ph+ NHL in patients with CML. The median age of patients with NHL and CML was 41 years. The follow-up time of patients with Ph+ NHL was significantly shorter (mean, <6 months) compared to the follow-up time of patients with Ph− NHL (mean, >15 months). Therefore the present study concludes that Ph+ NHL may be more aggressive compared with Ph+ NHL. The present study suggests that additional studies are required to assess the clinical and genetic characteristics of NHL patients with CML. PMID:27073575

  11. Fin-de-siècle Philadelphia and the founding of the Medical Library Association.

    PubMed Central

    Groen, F

    1999-01-01

    Philadelphia at the time of the founding of the Medical Library Association (MLA) is described. Several factors that promoted the birth of the association are discussed, including the rapid increase in the labor force and the rise of other health related professions, such as the American Hospital Association and the professionalization of nursing. The growth of the public hygiene movement in Philadelphia at the time of Sir William Osler's residency in the city is discussed. Finally, the rapid growth of the medical literature is considered a factor promoting the development of the association. This article continues the historical consideration of the MLA begun in the author's article on the three founders of the association. The background information is drawn from the items listed in the bibliography, and the conclusions are those of the author. Images PMID:10427436

  12. Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome

    PubMed Central

    Chandra, H. Sharat; Heistekamp, Nora C.; Hungerford, Alice; Morrissette, Jennifer J.D.; Nowell, Peter C.; Rowley, Janet D.; Testa, Joseph R.

    2011-01-01

    This report summarizes highlights of the ‘Philadelphia Chromosome Symposium: Past, Present and Future’, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contributions concerning the discovery and molecular characterization of the Ph chromosome and others who developed a highly successful therapy based on the specific molecular alteration observed in chronic myelogenous leukemia. Additional presentations highlighted future opportunities for the design of molecularly targeted therapies for various types of cancer. Also included here are reminiscences connected with the discovery of the Ph chromosome by David Hungerford and Peter Nowell, the discovery that the abnormality arises from a chromosomal translocation, by Janet Rowley, and the cloning of the 9;22 translocation breakpoints by Nora Heisterkamp, John Groffen and colleagues. PMID:21536234

  13. Trend Analyses of Users of a Syringe Exchange Program in Philadelphia, Pennsylvania: 1999-2014.

    PubMed

    Maurer, Laurie A; Bass, Sarah Bauerle; Ye, Du; Benitez, José; Mazzella, Silvana; Krafty, Robert

    2016-12-01

    This study examines trends of injection drug users' (IDUs) use of a Philadelphia, Pennsylvania, syringe exchange program (SEP) from 1999 to 2014, including changes in demographics, drug use, substance abuse treatment, geographic indicators, and SEP use. Prevention Point Philadelphia's SEP registration data were analyzed using linear regression, Pearson's Chi square, and t-tests. Over time new SEP registrants have become younger, more racially diverse, and geographically more concentrated in specific areas of the city, corresponding to urban demographic shifts. The number of new registrants per year has decreased, however syringes exchanged have increased. Gentrification, cultural norms, and changes in risk perception are believed to have contributed to the changes in SEP registration. Demographic changes indicate outreach strategies for IDUs may need adjusting to address unique barriers for younger, more racially diverse users. Implications for SEPs are discussed, including policy and continued ability to address current public health threats.

  14. Spatial and temporal patterns in Cimex lectularius (Hemiptera: Cimicidae) reporting in Philadelphia, PA.

    PubMed

    Mabud, Tarub S; Barbarin, Alexis M; Barbu, Corentin M; Levy, Katelyn H; Edinger, Jason; Levy, Michael Z

    2014-01-01

    We analyzed a comprehensive telephone log of pest infestation reports to assess the spatial and temporal trends in Cimex lectularius L. (bed bug) reporting throughout Philadelphia, PA. Citywide spatial analyses of reports from September 2011 to June 2012 revealed several statistically significant bed bug hotspots. However, these were small and diffuse. Temporal analyses of reports from December 2008 to May 2011 detected prominent seasonality in bed bug reporting, peaking in August and reaching a nadir in February each year. Controlling for seasonal cycling, the number of bed bug reports in Philadelphia increased steadily at a rate of approximately 4.5% per month (or 69.45% per year) from December 2008 to May 2011. While it may be difficult to spatially target citywide bed bug control measures because of the insects' widespread migration, interventions informed by seasonal trends may enhance efforts to curb the recent increases in urban bed bug populations.

  15. Update on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinib

    PubMed Central

    Emole, Josephine; Talabi, Taiwo; Pinilla-Ibarz, Javier

    2016-01-01

    Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia chromosome and the bcr-abl gene. The discovery of tyrosine kinase inhibitors (TKIs) revolutionized therapy for CML, such that durable response, increased overall survival, and increased progression-free survival of patients in chronic phase CML is now possible. Due to resistance and intolerance to imatinib, there was need for development of second- and third-generation TKIs for the treatment of CML. This review examines the role of nilotinib, an oral second-generation TKI, in the treatment of Philadelphia positive CML. The pharmacology, efficacy, and safety of nilotinib are critically evaluated. Patient-related issues, including tolerance, drug interactions, and quality of life issues are also examined. PMID:27013862

  16. The feasibility of refuse-fired energy generation in Philadelphia, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Christman, W. M., III

    1982-02-01

    The City of Philadelphia presently disposes of 816, 480 megagrams per year (MGY) of residential refuse, with 1 megagram = 10 to the 3rd power hilograms. Alternatives to a base case of continued incineration and landfilling are evaluated. It is assured that the feasibility studies will yield compatible products and will run a uniform economic analysis against the base case, using as inputs the outputs of the feasibility analyses.

  17. Drinking water turbidity and gastrointestinal illness in the elderly of Philadelphia

    PubMed Central

    Schwartz, J.; Levin, R.; Goldstein, R.

    2000-01-01

    STUDY OBJECTIVE—To investigate the association between drinking water quality and gastrointestinal illness in the elderly of Philadelphia.
DESIGN—Within the general population, children and the elderly are at highest risk for gastrointestinal disease. This study investigates the potential association between daily fluctuations in drinking water turbidity and subsequent hospital admissions for gastrointestinal illness of elderly persons, controlling for time trends, seasonal patterns, and temperature using Poisson regression analysis.
SETTING AND PARTICIPANTS—All residents of Philadelphia aged 65 and older in 1992-1993 were studied through their MEDICARE records.
MAIN RESULTS—For Philadelphia's population aged 65 and older, we found water quality 9 to 11 days before the visit was associated with hospital admissions for gastrointestinal illness, with an interquartile range increase in turbidity being associated with a 9% increase (95% CI 5.3%, 12.7%). In the Belmont service area, there was also an association evident at a lag of 4 to 6 days (9.1% increase, 95% CI 5.2, 13.3). Both associations were stronger in those over 75 than in the population aged 65-74. This association occurred in a filtered water supply in compliance with US standards.
CONCLUSIONS—Elderly residents of Philadelphia remain at risk of waterborne gastrointestinal illness under current water treatment practices. Hospitalisations represent a very small percentage of total morbidity.


Keywords: waterborne disease; drinking water; gastrointestinal illness; elderly PMID:10692962

  18. In Search of a Better Life: The Education and Housing Problems of Puerto Ricans in Philadelphia.

    ERIC Educational Resources Information Center

    Pennsylvania State Advisory Committee to the U.S. Commission on Civil Rights, Harrisburg.

    In early 1972, the Pennsylvania State Advisory Committee to the U.S. Commission on Civil Rights turned its attention to the growing Puerto Rican population in Philadelphia, a population estimated to be anywhere from 30,000 to 125,000. A two-day open meeting or informal hearing was held on June 6 and 7, 1972, to look at two major problem areas for…

  19. Using Multispectral Analysis in GIS to Model the Potential for Urban Agriculture in Philadelphia

    NASA Astrophysics Data System (ADS)

    Dmochowski, J. E.; Cooper, W. P.

    2010-12-01

    In the context of growing concerns about the international food system’s dependence on fossil fuels, soil degradation, climate change, and other diverse issues, a number of initiatives have arisen to develop and implement sustainable agricultural practices. Many seeking to reform the food system look to urban agriculture as a means to create localized, sustainable agricultural production, while simultaneously providing a locus for community building, encouraging better nutrition, and promoting the rebirth of depressed urban areas. The actual impact of such system, however, is not well understood, and many critics of urban agriculture regard its implementation as impractical and unrealistic. This project uses multispectral imagery from United States Department of Agriculture’s National Agricultural Imagery Program with a one-meter resolution to quantify the potential for increasing urban agriculture in an effort to create a sustainable food system in Philadelphia. Color infrared images are classified with a minimum distance algorithm in ArcGIS to generate baseline data on vegetative cover in Philadelphia. These data, in addition to mapping on the ground, form the basis of a model of land suitable for conversion to agriculture in Philadelphia, which will help address questions related to potential yields, workforce, and energy requirements. This research will help city planners, entrepreneurs, community leaders, and citizens understand how urban agriculture can contribute to creating a sustainable food system in a major North American city.

  20. Evolving Therapeutic Strategies for the Classic Philadelphia-Negative Myeloproliferative Neoplasms

    PubMed Central

    Kaplan, Jason B.; Stein, Brady L.; McMahon, Brandon; Giles, Francis J.; Platanias, Leonidas C.

    2016-01-01

    Despite the emergence of JAK inhibitors, there is a need for disease-modifying treatments for Philadelphia-negative myeloproliferative neoplasms (MPNs). JAK inhibitors ameliorate symptoms and address splenomegaly, but because of the heterogeneous contributors to the disease process, JAK inhibitor monotherapy incompletely addresses the burden of disease. The ever-growing understanding of MPN pathogenesis has provided the rationale for testing novel and targeted therapeutic agents, as monotherapies or in combination, in preclinical and clinical settings. A number of intriguing options have emerged, and it is hoped that further progress will lead to significant changes in the natural history of MPNs. PMID:26870834

  1. [Control discourses and power relations of yellow fever: Philadelphia in 1793].

    PubMed

    Kim, Seohyung

    2014-12-01

    1793 Yellow fever in Philadelphia was the most severe epidemics in the late 18th century in the United States. More than 10% of the population in the city died and many people fled to other cities. The cause of yellow fever in the United States had close relationship with slaves and sugar in Philadelphia. Sugarcane plantation had needed many labors to produce sugar and lots of Africans had to move to America as slaves. In this process, Aëdes aegypti, the vector of yellow fever had migrated to America and the circumstances of ships or cities provided appropriate conditions for its breeding. In this period, the cause of yellow fever could not be established exactly, so suggestions of doctors became entangled in political and intellectual discourses in American society. There was a critical conflict between Jeffersonian Republicanism and Federalism about the origin and treatment of yellow fever. Benjamin Rush, a Jeffersonian Republican, suggested urban sanitation reform and bloodletting. He believed the infectious disease happened because of unsanitary city condition, so he thought the United States could be a healthy nation by improvement of the public health and sanitation. He would like to cope with national crisis and develop American society on the basis of republicanism. While Rush suggested the improvement of public health and sanitation, the city government of Philadelphia suggested isolation of yellow fever patients and quarantine. City government isolated the patients from healthy people and it reconstructed space of hospital. Also, it built orphanages to take care of children who lost their parents during the epidemic and implemented power to control people put in the state of exception. Of course, city government tried to protect the city and nation by quarantine of every ship to Philadelphia. Control policies of yellow fever in 1793 showed different conflicts and interactions. Through the yellow fever, Jeffersonian Republicanism and Federalism had

  2. Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation

    PubMed Central

    Singh, Yadvinder; Bali, Chamandeep

    2013-01-01

    Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells and is typically well treated with combination chemotherapy, with a remission state after 5 years of 94% in children and 30–40% in adults. To establish how aggressive the disease is, further chromosome testing is required to determine whether the cancer is myeloblastic and involves neutrophils, eosinophils or basophils, or lymphoblastic involving B or T lymphocytes. This case study is on a 14-year-old patient diagnosed with a very aggressive form of ALL (positive for the Philadelphia chromosome mutation). A standard bone marrow transplant, aggressive chemotherapy and radiation therapy were revoked, with treatment being deemed a failure after 34 months. Without any other solutions provided by conventional approaches aside from palliation, the family administered cannabinoid extracts orally to the patient. Cannabinoid resin extract is used as an effective treatment for ALL with a positive Philadelphia chromosome mutation and indications of dose-dependent disease control. The clinical observation in this study revealed a rapid dose-dependent correlation. PMID:24474921

  3. Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation.

    PubMed

    Singh, Yadvinder; Bali, Chamandeep

    2013-09-01

    Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells and is typically well treated with combination chemotherapy, with a remission state after 5 years of 94% in children and 30-40% in adults. To establish how aggressive the disease is, further chromosome testing is required to determine whether the cancer is myeloblastic and involves neutrophils, eosinophils or basophils, or lymphoblastic involving B or T lymphocytes. This case study is on a 14-year-old patient diagnosed with a very aggressive form of ALL (positive for the Philadelphia chromosome mutation). A standard bone marrow transplant, aggressive chemotherapy and radiation therapy were revoked, with treatment being deemed a failure after 34 months. Without any other solutions provided by conventional approaches aside from palliation, the family administered cannabinoid extracts orally to the patient. Cannabinoid resin extract is used as an effective treatment for ALL with a positive Philadelphia chromosome mutation and indications of dose-dependent disease control. The clinical observation in this study revealed a rapid dose-dependent correlation.

  4. Quantifying Disparities in Urban Firearm Violence by Race and Place in Philadelphia, Pennsylvania: A Cartographic Study

    PubMed Central

    Morrison, Christopher N.; Jacoby, Sara F.; Dong, Beidi; Smith, Randi; Sims, Carrie A.; Wiebe, Douglas J.

    2017-01-01

    Objectives. To describe variability in the burden of firearm violence by race, income, and place in an urban context. Methods. We used Philadelphia Police Department data from 2013 to 2014 to calculate firearm assault rates within census block groups for both victim residence and event locations, stratifying by race and block group income. We used cartographic modeling to determine variations in incidence of firearm assault by race, neighborhood income, and place. Results. The overall rate of firearm assault was 5.0 times higher (95% confidence interval [CI] = 4.5, 5.6) for Black people compared with White people. Firearm assault rates were higher among Black people across all victim residence incomes. Relative risk of firearm assault reached 15.8 times higher (95% CI = 10.7, 23.2) for Black residents in the highest-income block groups when compared with high-income White individuals. Firearm assault events tended to occur in low-income areas and were concentrated in several “hot spot” locations with high proportions of Black residents. Conclusions. Profound disparity in exposure to firearm violence by race and place exists in Philadelphia. Black people were substantially more likely than White people to sustain firearm assault, regardless of neighborhood income. PMID:28103077

  5. Lessons for providers and hospitals from Philadelphia's obstetric services closures and consolidations, 1997-2012.

    PubMed

    Lorch, Scott A; Martin, Ashley E; Ranade, Richa; Srinivas, Sindhu K; Grande, David

    2014-12-01

    The Affordable Care Act is triggering an increase in hospital consolidation and mergers. How other hospitals respond to these disruptions in supply could influence patient outcomes. We examined the experience of Philadelphia County, Pennsylvania (coterminous with the city of Philadelphia), where thirteen of nineteen hospital obstetric units closed between 1997 and 2012. Between October 2011 and January 2012 we interviewed twenty-three key informants from eleven hospitals (six urban and five suburban) whose obstetric units remained open, to understand how the large number of closures affected their operations. Informants reported having confronted numerous challenges as a result of the obstetric unit closures, including sharp surges in delivery volume and an increase in the proportion of patients with public insurance or no insurance. Informants reported adopting a number of strategies, such as innovative staffing models, to cope with the added demand brought about by the closure of nearby obstetric units. Informants emphasized that interhospital communication could mitigate closures' stresses on the health care system. Our study supports the need for policy makers to anticipate reductions in supply and monitor patient outcomes.

  6. Emergency Preparedness for a Mass Gathering: the 2015 Papal Visit to Philadelphia.

    PubMed

    Paras, Emma; Butler, Matthew; Maguire, Brian F; Scarfone, Rich

    2016-09-29

    In September 2015, Pope Francis visited Philadelphia, Pennsylvania, and led outdoor events over the course of 2 days. As a result, The Children's Hospital of Philadelphia (CHOP) was faced with the challenge of planning for and responding to a mass gathering that was anticipated to be one of the largest in US history. As a result of unprecedented traffic restrictions, it was anticipated that patients, staff, and vendors would have severe challenges accessing the hospital, along with impaired communications from widespread cell phone service disruption. Previous mass gatherings have proven a need for early, detailed planning with multidisciplinary stakeholders, but little has been published on the impact of mass gatherings on area hospitals. This lack of data makes it difficult to predict the extent to which demand for hospital services would be increased and which services would be most affected. Early, coordinated planning allowed CHOP leaders to delegate responsibilities to those with specific expertise, prioritize needs, prevent duplication of efforts, and ensure engagement and accountability from key stakeholders. Emergency preparedness-led efforts including housing almost 1000 employees for 3 consecutive nights and assisting families with access allowed our hospital to maintain operations. The planning strategies shared here will provide emergency preparedness planners with a blueprint for future mass gathering preparedness. (Disaster Med Public Health Preparedness. 2016;page 1 of 10).

  7. Genomic Analysis Reveals Novel Diversity among the 1976 Philadelphia Legionnaires’ Disease Outbreak Isolates and Additional ST36 Strains

    PubMed Central

    Mercante, Jeffrey W.; Morrison, Shatavia S.; Desai, Heta P.; Raphael, Brian H.; Winchell, Jonas M.

    2016-01-01

    Legionella pneumophila was first recognized as a cause of severe and potentially fatal pneumonia during a large-scale outbreak of Legionnaires’ disease (LD) at a Pennsylvania veterans’ convention in Philadelphia, 1976. The ensuing investigation and recovery of four clinical isolates launched the fields of Legionella epidemiology and scientific research. Only one of the original isolates, “Philadelphia-1”, has been widely distributed or extensively studied. Here we describe the whole-genome sequencing (WGS), complete assembly, and comparative analysis of all Philadelphia LD strains recovered from that investigation, along with L. pneumophila isolates sharing the Philadelphia sequence type (ST36). Analyses revealed that the 1976 outbreak was due to multiple serogroup 1 strains within the same genetic lineage, differentiated by an actively mobilized, self-replicating episome that is shared with L. pneumophila str. Paris, and two large, horizontally-transferred genomic loci, among other polymorphisms. We also found a completely unassociated ST36 strain that displayed remarkable genetic similarity to the historical Philadelphia isolates. This similar strain implies the presence of a potential clonal population, and suggests important implications may exist for considering epidemiological context when interpreting phylogenetic relationships among outbreak-associated isolates. Additional extensive archival research identified the Philadelphia isolate associated with a non-Legionnaire case of “Broad Street pneumonia”, and provided new historical and genetic insights into the 1976 epidemic. This retrospective analysis has underscored the utility of fully-assembled WGS data for Legionella outbreak investigations, highlighting the increased resolution that comes from long-read sequencing and a sequence type-matched genomic data set. PMID:27684472

  8. Young People Take Their Rightful Places as Full and Contributing Members of a World Class Workforce: Philadelphia Youth Network Annual Report 2006

    ERIC Educational Resources Information Center

    Philadelphia Youth Network, 2006

    2006-01-01

    The title of this year's annual report has particular meaning for all of the staff at the Philadelphia Youth Network. The phrase derives from Philadelphia Youth Network's (PYN's) new vision statement, developed as part of its recent strategic planning process, which reads: All of our city's young people take their rightful places as full and…

  9. The Plight of the "Able Student": Ruth Wright Hayre and the Struggle for Equality in Philadelphia's Black High Schools, 1955-1965

    ERIC Educational Resources Information Center

    Delmont, Matthew

    2010-01-01

    This article features Ruth Wright Hayre, Philadelphia's first black high school teacher and principal whose work at William Penn High School for Girls became a model for counseling and motivation programs at other majority-black high schools in Philadelphia, expanding educational and career opportunities for thousands of "able" students.…

  10. Extent and frequency of inundation of Schuylkill River flood plain from Conshohocken to Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Alter, A.T.

    1966-01-01

    Information on flood conditions plays an important part in the development and use of river valleys. This report presents maps, profiles, and flood-frequency relations developed from past flood experience on the Schuylkill River from Conshohocken to Philadelphia, Pa. The maps and profiles are used to define the areal extent and depth of flooding of the August 24, 1933, and August 19, 1955, floods. The flood of October 4, 1869, which is the greatest flood known on the lower Schuylkill River, is presented on the flood profile and on the ten cross sections. The area inundated by the 1869 flood is not defined because insufficient data are available and because hydrologic and hydraulic conditions have undoubtedly changed to such an extent that such a definition would have little present significance. The basic flood data were prepared to aid individuals, organizations, and governmental agencies in making sound decisions for the safe and economical development of the lower Schuylkill River valley. Recommendations for land use, or suggestions for limitations of land use, are not made in this report.The responsibility for planning for the optimum land use in the flood plain and the implementation of flood-plain regulations to achieve such optimum use rests with the State and local interests. The preparation of this report was undertaken after consultation with representatives of the Philadelphia City Planning Commission and the Montgomery County Planning Commission who expressed the need for flood-plain information and their willingness to consider floodplain regulations.The area covered by this report extends downstream along the Schuylkill River from Plymouth Dam in Conshohocken to the mouth of Wissahickon Creek in Philadelphia. Flooding along Wissahickon Creek is not included in the report. The reach studied extends from 13.0 miles to 21.0 miles upstream from the river mouth. All river distances used in the report are river miles upstream from the mouth of the

  11. Correlates to Human Papillomavirus Vaccination Status and Willingness to Vaccinate in Low-Income Philadelphia High School Students

    ERIC Educational Resources Information Center

    Bass, Sarah B.; Leader, Amy; Shwarz, Michelle; Greener, Judith; Patterson, Freda

    2015-01-01

    Background: Little is known about the correlates of human papillomavirus (HPV) vaccination or willingness to be vaccinated in urban, minority adolescents. Methods: Using responses to the 2013 Youth Risk Behavior Survey in Philadelphia, a random sample of high schools provided weighted data representing 20,941 9th to 12th graders. Stratified by…

  12. Racial Differences in the Transition to Adulthood: A Follow-Up Study of the Philadelphia Youth Study.

    ERIC Educational Resources Information Center

    Furstenberg, Frank F., Jr.; Kmec, Julie A.

    This research derives from the most recent wave of a longitudinal study of nearly 500 families in urban Philadelphia neighborhoods collected over a 9-year time span. Earlier findings revealed remarkable continuity in success trajectories from early to mid-adolescence despite hazards imposed by poor neighborhoods, low economic standing, and poor…

  13. School Autonomy and District Support: How Principals Respond to a Tiered Autonomy Initiative in Philadelphia Public Schools

    ERIC Educational Resources Information Center

    Steinberg, Matthew P.; Cox, Amanda Barrett

    2017-01-01

    A tiered autonomy policy was recently implemented in Philadelphia, where select principals were granted autonomy to manage school operations while others were promised greater district support to improve school functioning. This article provides evidence on how principals used their autonomy and the extent of district support for non-autonomous…

  14. EPA Regional Administrator to kick off Run for Clean Air as part of Philadelphia Earth Day festivities

    EPA Pesticide Factsheets

    PHILADELPHIA, Pa. (April 17, 2015) - EPA Mid-Atlantic Regional Administrator Shawn M. Garvin will get regional Earth Day festivities started Saturday morning as he opens ceremonies for the Run for Clean Air presented by Toyota Hybrids in front of th

  15. 40 CFR 81.15 - Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Air Quality Control Region (Pennsylvania-New Jersey-Delaware). 81.15 Section 81.15 Protection of... Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware). The Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware) consists of the territorial...

  16. 40 CFR 81.15 - Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Air Quality Control Region (Pennsylvania-New Jersey-Delaware). 81.15 Section 81.15 Protection of... Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware). The Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware) consists of the territorial...

  17. 40 CFR 81.15 - Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Air Quality Control Region (Pennsylvania-New Jersey-Delaware). 81.15 Section 81.15 Protection of... Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware). The Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware) consists of the territorial...

  18. 40 CFR 81.15 - Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Air Quality Control Region (Pennsylvania-New Jersey-Delaware). 81.15 Section 81.15 Protection of... Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware). The Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware) consists of the territorial...

  19. 40 CFR 81.15 - Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Air Quality Control Region (Pennsylvania-New Jersey-Delaware). 81.15 Section 81.15 Protection of... Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware). The Metropolitan Philadelphia Interstate Air Quality Control Region (Pennsylvania-New Jersey-Delaware) consists of the territorial...

  20. Variations on a Theme: The Shift from Distinction to Commonality in Philadelphia's Diverse Provider Model 2002-2008

    ERIC Educational Resources Information Center

    Bulkley, Katrina E.; Travers, Eva

    2013-01-01

    Recent years have seen a growing push toward Portfolio Management Models that incorporate a variety of "providers" operating public schools. One rationale for this is that such organizations can offer distinct and innovative educational practices. This article describes the Diverse Provider Model implemented in Philadelphia from…

  1. Follow Through Pupil Achievement Characteristics in Philadelphia, 1971-1972 through 1975-1976. Report No. 77121.

    ERIC Educational Resources Information Center

    McKinney, John T.

    This report provides achievement information from the Philadelphia, Pa. Follow Through program in Mathematics and Reading for the five years, 1971-1972 through 1975-1976. The data are drawn from cross-sectional analyses, focusing primarily on mean score performance in Total Mathematics and Total Reading on city-wide tests. The principal findings…

  2. Boosting Adolescent and Young Adult Literacy: An Examination of Literacy Teaching and Learning in Philadelphia's Accelerated High Schools

    ERIC Educational Resources Information Center

    Gold, Eva; Edmunds, Kimberly; Maluk, Holly; Reumann-Moore, Rebecca

    2011-01-01

    In 2010-11, the School District of Philadelphia (the District) operated thirteen accelerated high schools that served approximately 2,000 under-credited, over-age students. Each of the accelerated schools was managed by one of seven external providers, each with its own educational approach, and each with a contractual agreement with the…

  3. Privatization "Philly Style": What Can Be Learned from Philadelphia's Diverse Provider Model of School Management? A Research Brief

    ERIC Educational Resources Information Center

    Christman, Jolley Bruce; Gold, Eva; Herold, Benjamin

    2005-01-01

    In this brief, the authors examine the creation, evolution, and expansion of Philadelphia's diverse provider model through the lens of this theory of change; they show that the beliefs and assumptions underlying the diverse provider model have been amended over time; and they illustrate how district and provider leaders have reshaped the model in…

  4. Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

    ClinicalTrials.gov

    2017-02-07

    B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; BCR-ABL1 Fusion Protein Expression; Minimal Residual Disease; Philadelphia Chromosome Positive; T Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

  5. 33 CFR 165.T05-0495 - Safety Zone, Sugar House Casino Fireworks Display, Delaware River; Philadelphia, PA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone, Sugar House Casino Fireworks Display, Delaware River; Philadelphia, PA. 165.T05-0495 Section 165.T05-0495 Navigation and... Areas Fifth Coast Guard District § 165.T05-0495 Safety Zone, Sugar House Casino Fireworks...

  6. Acquisition Policy Planning and Litigation: Language Planning in the Context of "Y.S. v. District of Philadelphia."

    ERIC Educational Resources Information Center

    Skilton, Ellen E.

    1992-01-01

    This paper discusses language policy and educational practice in the context of a class action law suit filed on behalf of Asian students in Philadelphia concerning their linguistic and academic needs. It addresses both macro and micro perspectives in its discussion of litigation policy, acquisition policy planning, and Asian Americans in the…

  7. Report of Supportive Services and Parent Involvement in Follow Through in Philadelphia, 1974-1975. Report No. 7769.

    ERIC Educational Resources Information Center

    Atkins, Janice; And Others

    This report presents information on Follow Through supportive services (medical, dental, psychological and social) and parent involvement in 18 Philadelphia public schools for the 1974-75 school year. Medical services information indicated that, despite the fact that seven schools had no medical contracts until January or later, contracted…

  8. Localization of preferential sites of rearrangement within the BCR gene in Philadelphia chromosome-positive acute lymphoblastic leukemia

    SciTech Connect

    Denny, C.T.; Shah, N.P.; Ogden, S.; Willman, C.; McConnell, T.; Crist, W.; Carroll, A.; Witte, O.N. )

    1989-06-01

    The Philadelphia chromosome associated with acute lymphoblastic leukemia (ALL) has been linked to a hybrid BCR/ABL protein product that differs from that found in chronic myelogenous leukemia. This implies that the molecular structures of the two chromosomal translocations also differ. Localization of translocation breakpoints in Philadelphia chromosome-positive ALL has been impeded due to the only partial characterization of the BCR locus. The authors have isolated the entire 130-kilobase BCR genomic locus from a human cosmid library. They have demonstrated that these breakpoints are all located at the 3{prime} end of the intron around an unusual restriction fragment length polymorphism caused by deletion of a 1-kilobase fragment containing Alu family reiterated sequences. This clustering is unexpected in light of previous theories of rearrangement in Philadelphia chromosome-positive chronic myelogenous leukemia that would have predicted a random dispersion of breakpoints in the first intron in Philadelphia chromosome-positive ALL. The proximity of the translocation breakpoints to this constitutive deletion may indicate shared mechanisms of rearrangement or that such polymorphisms mark areas of the genome prone to recombination.

  9. A POPULATION EXPOSURE MODEL FOR PARTICULATE MATTER: CASE STUDY RESULTS FOR PM 2.5 IN PHILADELPHIA, PA

    EPA Science Inventory

    A population exposure model for particulate matter (PM), called the Stochastic Human Exposure and Dose Simulation (SHEDS-PM) model, has been developed and applied in a case study of daily PM2.5 exposures for the population living in Philadelphia, PA. SHEDS-PM is a probabilisti...

  10. Class Action, Community Organization, and School Reform. Aspira of New York, Philadelphia Welfare Rights Organization and Harlem Parents Union.

    ERIC Educational Resources Information Center

    Goldberg, Gertrude S.

    1976-01-01

    This report on educational reform shows how three dynamic but quite different organizations are currently attempting to secure quality education for urban disadvantaged children. Aspira of New York, Philadelphia Welfare Rights Organization, and Harlem Parents Union are three self-help groups that seek quality education for poor children but differ…

  11. A Summary of Six Major Evaluation Reports on Follow Through in Philadelphia, 1974-1975. Report No. 7713.

    ERIC Educational Resources Information Center

    Goodwin, Judith

    This report is a non-technical summary of six major evaluation reports on the Follow Through Program in Philadelphia, 1974-75. Cross-sectional analyses of February, 1975 achievement data indicate that Total Follow Through exceeds Total Non-Follow Through performance in all test areas in kindergarten through second grade, but not in third grade.…

  12. Staying in the Hood: Black Lesbian and Transgender Women and Identity Management in North Philadelphia.

    PubMed

    Brooks, Siobhan

    2016-12-01

    The concept Don't Ask, Don't Tell regarding Black LGBT sexuality in Black communities has been an acceptable form of identity management for Black LGBT people. In other words, Black LGBT people are accepted as long as they are not vocal about their sexuality. However, this is changing with the issue of gay marriage, which is creating a space where Black LGBT people are more open about their gender identity and sexuality in heterosexual Black spaces. This new form of openness allows Black LGBT people to "stay in" their communities, as opposed to coming out. In this article I examine how Black LGBT women in North Philadelphia stay in their communities: being politically active regarding LGBT issues, disengaging from LGBT issues, passing, and educating straight Black people about issues affecting the Black LGBT community. I conclude with implications of staying in and intersectionality among Black heterosexual and LGBT women fighting for social change.

  13. Association of the Philadelphia chromosome and 5q- in secondary blood disorder

    SciTech Connect

    Dastugue, N.; Demur, C.; Pris, F.; Bugat, R.; Attal, M.; Bourrouillou, G.; Colombies, P.

    1988-02-01

    A patient developed a secondary blood disorder 7 years after radiotherapy for a gastric lymphoma. The initial myelodysplastic syndrome evolved to a myeloproliferative phase with transient polycythemia, progressive thrombocythemia, and hyperleukocytosis. Chromosome analysis performed in the terminal phase showed del(5)(q13q31),t(9;22)(q34;q11), and a complex rearrangement involving chromosomes number2 and number3. A correlation between chromosomal abnormalities and hematologic findings could be established. In this case, we have assumed that the Philadelphia translocation is a late event, due to prior mutagen exposure, and its association with a common secondary abnormality (5q-), followed by a progressively developing myeloproliferative phase. Furthermore, the association of Ph and 5q- in a single clone seems to indicate that the same stem cell is affected by these two abnormalities.

  14. Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest

    PubMed Central

    Mondet, Julie; Hussein, Kais; Mossuz, Pascal

    2015-01-01

    Cytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph− MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed. PMID:26525644

  15. University-assisted community school program of West Philadelphia: democratic partnerships that make a difference.

    PubMed

    Harkavy, Ira

    2005-01-01

    The university-assisted community school model is showing results for children and youth in West Philadelphia. The University of Pennsylvania's (Penn's) Center for Community Partnerships has coordinated universitywide efforts, in partnership with the community, in order to create and develop community school programs. The Sayre program aims to become a university-assisted community school, with a comprehensive community problem-solving curriculum and communitywide program that is fully integrated across both the Sayre curriculum and the curriculum of a number of Penn's schools. The Penn-Sayre project demonstrates that higher education can be a permanent anchor for revitalizing schools and communities if the vast resources it possesses, particularly its faculty, students, and staff, are brought to bear in a coordinated fashion.

  16. Surface geophysics and porewater evaluation at the Lower Darby Creek Area Superfund Site, Philadelphia, Pennsylvania, 2013

    USGS Publications Warehouse

    Walker, Charles W.; Degnan, James R.; Brayton, Michael J.; Cruz, Roberto M.; Lorah, Michelle M.

    2015-01-01

    In cooperation with the U.S. Environmental Protection Agency (EPA), Region 3, the U.S. Geological Survey (USGS) is participating in an ongoing study to aid in the identification of subsurface heterogeneities that may act as preferential pathways for contaminant transport in and around the Lower Darby Creek Area (LDCA) Superfund Site, Philadelphia Pa. Lower Darby Creek, which flows into the Delaware River, borders the western part of the former landfill site. In 2013, the USGS conducted surface geophysics measurements and stream porewater sampling to provide additional data for EPA’s site characterization. This report contains data collected from field measurements of direct current (DC) resistivity, frequency-domain electromagnetic (FDEM) surveys, and stream porewater specific conductance (SC).

  17. Philadelphia Electric Company's East Fish Passage Facility at the Conowingo Dam

    SciTech Connect

    Brunot, J.T. ); Frese, C.R. )

    1992-01-01

    The Conowingo East Fish Passage Facility employs the latest technology to attract, collect, and pass American Shad upstream of the dam as they make their annual spring spawning run u the Susquehanna River. The facility is designed to move up to 750,000 American Shad and 5 million River Herring per season, i.e., April 1 through June 15. The facility is designed so that if the numbers of American Shad warrant, the capacity of the flit may be doubled in the future. This paper will discuss the key elements in the design of a fishway, including planning, engineering, and hydraulic modelling. The paper will also address installation and operational experience at Philadelphia Electric's new East Side Fish Passage Facility.

  18. Familial translocation involving chromosomes 1 and 9 in a patient with Philadelphia-positive CML

    SciTech Connect

    Rehman, K.; Rosner, F.; Shanske, A.

    1994-09-01

    CML has provided a model for understanding the genetic basis of neoplasia. Approximately 5% of Philadelphia-positive patients have a variant chromosome rearrangement. We recently evaluated a patient with a previously unreported simple variant translocation that is part of a familial rearrangement. He had a constitutional translocation, t(1;9)(p21;p22), which was initially identified after his wife had a routine amniocentesis. Case report: K.H. was a 54-year-old male with CML for 4 years. He had been treated until recently with hydroxyurea. An abnormal male karyotype, 46,XY,t(1;9)(q21;p22),t(9;22)(q34;q11) was recorded from an unstimulated blood sample soon after diagnosis. Both translocations involved the same number 9 homologue resulting in a derivative 9(1pter{r_arrow}1q21::9p22{r_arrow}9q34::22q11{r_arrow}22qter). A recent CT scan of the chest showed a lytic lesion of a rib with associated soft tissue mass in the right costo-vertebral angle. He was hospitalized for progressive pain in the right lower chest and fever, treated for a UTI, required multiple transfusions for declining hemoglobin and platelets and died shortly thereafter. Autopsy revealed widespread chloromas as part of terminal CML. At least 13 complex rearrangements involving chromosomes 1, 9 and 22 are known. Our case represents a unique rearrangement with a familial component and also unique breakpoints for a Philadelphia variant. In line with the current view of cancer as a clonal disorder, perhaps the constitutional translocation contributed to the multi-step nature of the malignant transformation. In fact, a number of cancer-specific breakpoints in both regions of 1p and 9p are involved in the familial translocation.

  19. C2 Body Fracture: Report of Cases Managed Conservatively by Philadelphia Collar

    PubMed Central

    Sadeghian, Homa

    2016-01-01

    Study Design Case series. Purpose To present results of conservative management in patients with pure C2 body fractures. Overview of Literature Axis body fractures, a less common subgroup of C2 fractures, are commonly classified as vertical coronal, vertical sagittal, and transverse subtypes. While the treatment paradigm for other C2 fractures is clear, there is insufficient evidence to support treatment guidelines for C2 body fractures. Methods Eleven patients with pure C2 body fractures were managed with external immobilization and followed thereafter. Results All neurologic examinations were normal. In computed tomography (CT) scans, four, two, three, and two patients had a coronal, sagittal, horizontal, and burst fracture, respectively. Magnetic resonance imaging showed hematoma and partial rupture in the anterior longitudinal ligament in four patients, posterior ligamentous complex injury in one, and normal ligamentous structure in six. All fractures were managed conservatively using the Philadelphia collar, which was continued until complete disappearance of symptoms (within 1–3 months in all patients). The decision to discontinue the neck collar was made by a dynamic neck X-ray and CT scan that showed complete bony fusion. All patients were then followed for an additional 1.5 years (mean follow-up of 21 months for all patients). No patient showed any neurologic symptoms or deficits during the follow-up period. Conclusions In patients with pure C2 body fracture, non-operative management with Philadelphia neck collar is a safe and efficacious option, even in the presence of some sort of ligamentous injury. PMID:27790321

  20. Simulation of ground-water flow in the Potomac-Raritan-Magothy aquifer system near the Defense Supply Center Philadelphia, and the Point Breeze Refinery, southern Philadelphia County, Pennsylvania

    USGS Publications Warehouse

    Schreffler, C.L.

    2001-01-01

    Ground-water flow in the Potomac-Raritan- Magothy aquifer system (PRM) in south Philadelphia and adjacent southwestern New Jersey was simulated by use of a three-dimensional, seven-layer finite-difference numerical flow model. The simulation was run from 1900, which was prior to groundwater development, through 1995 with 21 stress periods. The focus of the modeling was on a smaller area of concern in south Philadelphia in the vicinity of the Defense Supply Center Philadelphia (DSCP) and the Point Breeze Refinery (PBR). In order to adequately simulate the ground-water flow system in the area of concern, a much larger area was modeled that included parts of New Jersey where significant ground-water withdrawals, which affect water levels in southern Philadelphia, had occurred in the past. At issue in the area of concern is a hydrocarbon plume of unknown origin and time of release. The ground-water-flow system was simulated to estimate past water-level altitudes in and near the area of concern and to determine the effect of the Packer Avenue sewer, which lies south of the DSCP, on the ground-water-flow system. Simulated waterlevel altitudes for the lower sand unit of the PRM on the DSCP prior to 1945 ranged from pre-development, unstressed altitudes to 3 feet below sea level. Simulated water-level altitudes for the lower sand unit ranged from 3 to 7 feet below sea level from 1946 to 1954, from 6 to 10 feet below sea level from 1955 to 1968, and from 9 to 11 feet below sea level from 1969 to 1978. The lowest simulated water-level altitude on the DSCP was 10.69 feet below sea level near the end of 1974. Model simulations indicate ground water was infiltrating the Packer Avenue sewer prior to approximately 1947 or 1948. Subsequent to that time, simulated ground-water-level altitudes were lower than the bottom of the sewer.

  1. Urban sustainable energy development: A case study of the city of Philadelphia

    NASA Astrophysics Data System (ADS)

    Argyriou, Iraklis

    This study explores the role of cities in sustainable energy development through a governance-informed analysis. Despite the leading position of municipalities in energy sustainability, cities have been mostly conceptualized as sites where energy development is shaped by external policy scales, i.e. the national level. A growing body of research, however, critiques this analytical perspective, and seeks to better understand the type of factors and dynamics that influence energy sustainability within a multi-level policy context for urban energy. Given that particular circumstances are applicable across cities, a context-specific analysis can provide insight regarding how sustainable energy development takes place in urban areas. In applying such an analytical perspective on urban energy sustainability, this study undertakes a qualitative case study analysis for the city of Philadelphia, Pennsylvania, by looking at four key local policy initiatives relevant to building energy efficiency and solar electricity development at the municipal government and city-wide level. The evaluation of the initiatives suggests that renewable electricity use has increased substantially in the city over the last years but the installed capacity of local renewable electricity systems, including solar photovoltaics, is low. On the other hand, although the city has made little progress in meeting its building energy efficiency targets, more comprehensive action is taken in this area. The study finds that the above outcomes have been shaped mainly by four factors. The first is the city government's incremental policy approach aiming to develop a facilitative context for local action. The second is the role that a diverse set of stakeholders have in local sustainable energy development. The third is the constraints that systemic policy barriers create for solar power development. The fourth is the ways through which the relevant multi-level policy environment structures the city

  2. Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia

    ClinicalTrials.gov

    2015-10-29

    B-cell Adult Acute Lymphoblastic Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia

  3. The relationship between treatment modality, demographic characteristics, and staff perceptions concerning their jobs in 26 Philadelphia drug treatment centers.

    PubMed

    Bausell, R B; Rinkus, A; Watson, D D

    1979-01-01

    The staffs of 26 Philadelphia drug treatment centers, representing four major treatment modalities, were interviewed concerning their attitudes and perceptions of treatment and the treatment milieu. By employing canonical correlation, two basic modality contrasts were found that significantly differentiated these attitudes and perceptions: (1) staff in small therapeutic communities tended to manifest more positive attitudes than their counterparts in large methadone maintenance settings, and (2) outpatient drug-free staff tended to be more satisfied and optimistic than detoxification staff.

  4. At risk for HIV infection: incarcerated women in a county jail in Philadelphia.

    PubMed

    Bond, L; Semaan, S

    1996-01-01

    This study presents the results of a needs assessment survey conducted with 66 incarcerated women in a large Philadelphia county jail during the winter of 1993. Results indicated that prior to incarceration, these women engaged in very high risk sexual and drug use behaviors, and had experienced a myriad of other problems that may contribute to their risk for HIV infection. Of the 66 women who participated in the study, over three-fourths had used crack cocaine, nearly one-half had traded sex for drugs and money in the six months prior to incarceration, one-third reported a prior history of injection drug use, and one-half report sexual contact with a male partner who injected drugs. In addition, one-fourth of the study sample had been homeless during the year prior to incarceration, one-half reported a prior history of sexual abuse, three-fourths had been physically beaten by a boyfriend or spouse, and nearly one-half had a prior history of syphilis. Although limited in scope, the results of the study have important implications for developing relevant jail-based HIV risk reduction programs for women. The results provide strong evidence for the need for interventions that address not only the HIV-related risk behaviors of incarcerated women, but also the underlying social problems that contribute to their risk of HIV infection.

  5. Secondary Philadelphia chromosome and erythrophagocytosis in a relapsed acute myeloid leukemia after hematopoietic cell transplantation

    PubMed Central

    Kelemen, Katalin; Galani, Komal; Conley, Christopher R.; Greipp, Patricia T.

    2015-01-01

    The acquisition of Philadelphia chromosome (Ph) as a secondary change during the course of hematopoietic malignancies is rare and is associated with poor prognosis. Few cases of secondary Ph have been reported after hematopoietic cell transplantation (HCT). A secondary Ph at relapse is of clinical importance because it provides a therapeutic target for tyrosine kinase inhibitors along with or in replacement of chemotherapy. We describe a case of relapsed acute myeloid leukemia after HCT that developed a BCR/ABL-1 translocation along with erythrophagocytosis by blasts as a secondary change at the time of relapse. The progression of this patient's myeloid neoplasm from myelodysplastic syndrome to acute myeloid leukemia and relapsed AML after HCT was accompanied by a stepwise cytogenetic evolution: a deletion 20q abnormality subsequently acquired deletion 7q and, finally, at relapse after HCT, a secondary Ph was gained. The relationship between the secondary Ph and the erythrophagocytosis by blasts is not clear. We review the possible pathogenesis and cytogenetic associations of erythrophagocytosis by blasts, a rare feature in acute leukemias. PMID:25074248

  6. Water quality data for precipitation and storm runoff in Pennypack Creek Basin, Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Speight, D.W.

    1989-01-01

    This report presents data on the chemistry of precipitation and storm runoff that were collected during 29 storms from July 1979 through November 1980, in an urban environment in the Pennypack Creek basin, Philadelphia, Pennsylvania. Daily mean and instantaneous stream discharge data were collected at two U.S. Geological Survey gaging stations. Water-quality data collected from these sites and from one storm-sewer sampling site included nutrients, chemical and biochemical oxygen demands, solids, metals, major anions, other constituents, and pH. Instantaneous loads of selected constituents were computed. Chemical oxygen demand, biochemical oxygen demand, sulfate, alkalinity, chloride, and dissolved solids generally were low in precipitation and runoff. During the November 5, 1980 storm at Pine Road, dissolved nitrate concentrations equaled or exceeded 10 milligrams per liter in 17 percent of the samples analyzed and dissolved ammonia nitrogen concentrations exceeded 2.5 milligrams per liter. Generally, a comparison of median concentration of copper, lead, or zinc in precipitation and runoff at the Tustin Street storm-sewer site showed that median concentrations in precipitation were greater than those in runoff.

  7. 56th and Walnut: A Philly Gut Rehab Development; Philadelphia, Pennsylvania (Fact Sheet)

    SciTech Connect

    Not Available

    2013-11-01

    Load-bearing brick-masonry multifamily buildings are prevalent in urban areas across much of the Northeast and mid-Atlantic. In most instances, these buildings are un-insulated unless they have been renovated within the past two decades. Affordable housing capital budgets typically limit what can be spent and energy improvements often take a back seat to basic capital improvements such as interior finish upgrades and basic repairs. The Consortium for Advanced Residential Buildings (CARB) is researching cost effective solution packages for significant energy efficiency and indoor air-quality improvements in these urban buildings. To explore how these low-cost retrofits can effectively integrate energy efficiency upgrades, CARB partnered with Columbus Property Management and Development, Inc. on a community-scale gut rehabilitation project located at 56th Street and Walnut Street in Philadelphia, consisting of 32 units in eleven 3-story buildings. These buildings were built in the early 1900s using stone foundations and solid brick-masonry walls. They were renovated in the 1990s to have interior light gauge metal framing with R-13 batt in the above-grade walls, induced-draft furnaces, and central air conditioning.

  8. ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells

    PubMed Central

    Karvela, Maria; Baquero, Pablo; Kuntz, Elodie M.; Mukhopadhyay, Arunima; Mitchell, Rebecca; Allan, Elaine K.; Chan, Edmond; Kranc, Kamil R.; Calabretta, Bruno; Salomoni, Paolo; Gottlieb, Eyal; Holyoake, Tessa L.; Helgason, G. Vignir

    2016-01-01

    ABSTRACT A major drawback of tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is that primitive CML cells are able to survive TKI-mediated BCR-ABL inhibition, leading to disease persistence in patients. Investigation of strategies aiming to inhibit alternative survival pathways in CML is therefore critical. We have previously shown that a nonspecific pharmacological inhibition of autophagy potentiates TKI-induced death in Philadelphia chromosome-positive cells. Here we provide further understanding of how specific and pharmacological autophagy inhibition affects nonmitochondrial and mitochondrial energy metabolism and reactive oxygen species (ROS)-mediated differentiation of CML cells and highlight ATG7 (a critical component of the LC3 conjugation system) as a potential specific therapeutic target. By combining extra- and intracellular steady state metabolite measurements by liquid chromatography-mass spectrometry with metabolic flux assays using labeled glucose and functional assays, we demonstrate that knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle. This leads to increased oxidative phosphorylation and mitochondrial ROS accumulation. Furthermore, following ROS accumulation, CML cells, including primary CML CD34+ progenitor cells, differentiate toward the erythroid lineage. Finally, ATG7 knockdown sensitizes CML progenitor cells to TKI-induced death, without affecting survival of normal cells, suggesting that specific inhibitors of ATG7 in combination with TKI would provide a novel therapeutic approach for CML patients exhibiting persistent disease. PMID:27168493

  9. Treating relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia: liposome-encapsulated vincristine

    PubMed Central

    Davis, Tyler; Farag, Sherif S

    2013-01-01

    Acute lymphoblastic leukemia (ALL) remains a disease with poor outcomes in adults. While induction chemotherapy achieves a complete remission in almost 90% of patients, the majority will relapse and die of their disease. Relapsed ALL is associated with a high reinduction mortality and chemotherapy resistance, with allogeneic hematopoietic stem cell transplantation offering the only therapy with curative potential. However, there is no efficacious and well tolerated standard regimen accepted as a “bridge” to allogeneic stem cell transplantation or as definitive treatment for patients who are not transplant candidates. Vincristine is an active drug in patients with ALL, but its dose intensity is limited by neurotoxicity, and its full potential as an anticancer drug is thus not realized. Encapsulation of vincristine into sphingomyelin and cholesterol nanoparticle liposomes facilitates dose-intensification and densification to enhanced target tissues with reduced potential for toxicity. Vincristine sulfate liposome injection (VSLI) is associated with significant responses in clinically advanced ALL, and has recently been approved by the US Food and Drug Administration for treatment of relapsed and clinically advanced Philadelphia chromosome-negative ALL. This review provides an overview of the preclinical and clinical studies leading to the approval of VSLI for the treatment of relapsed and refractory ALL, and suggests potential areas of future clinical development. PMID:24072970

  10. Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellanii.

    PubMed Central

    Steinert, M; Emödy, L; Amann, R; Hacker, J

    1997-01-01

    Legionella pneumophila is an aquatic bacterium and is responsible for Legionnaires' disease in humans. Free-living amoebae are parasitized by legionellae and provide the intracellular environment required for the replication of this bacterium. In low-nutrient environments, however, L. pneumophila is able to enter a non-replicative viable but nonculturable (VBNC) state. In this study, L. pneumophila Philadelphia I JR 32 was suspended in sterilized tap water at 10(4) cells/ml. The decreasing number of bacteria was monitored by CFU measurements, acridine orange direct count (AODC), and hybridization with 16S rRNA-targeted oligonucleotide probes. After 125 days of incubation in water, the cells were no longer culturable on routine plating media; however, they were still detectable by AODC and by in situ hybridization. The addition of Acanthamoeba castellanii to the dormant bacteria resulted in the resuscitation of L. pneumophila JR 32 to a culturable state. A comparison of plate-grown legionellae and reactivated cells showed that the capacity for intracellular survival in human monocytes and intraperitoneally infected guinea pigs, which is considered a parameter for virulence, was not reduced in the reactivated cells. However, reactivation of dormant legionellae was not observed in the animal model. PMID:9143134

  11. Addressing the Health Needs of High-Risk Filipino Americans in the Greater Philadelphia Region.

    PubMed

    Bhimla, Aisha; Yap, Lauren; Lee, Minsun; Seals, Brenda; Aczon, Hermie; Ma, Grace X

    2017-04-01

    Filipino Americans represent one of the largest and most diverse immigrant populations in the United States. It has been established that chronic diseases are a significant public health issue affecting this population. We conducted a health needs assessment of 200 Filipino Americans aged 18 years or older residing in the greater Philadelphia region. Study participants were recruited from eight Filipino community-based organizations in the region. Information about demographic and acculturative characteristics, health behaviors, self-reported chronic health conditions, and chronic disease perception were collected. Participants were older and highly acculturated. With regards to health behaviors, several did not meet dietary fruit and vegetables intake and physical activity guidelines. The top five health conditions were high blood pressure (67.5 %), high blood cholesterol (57.1 %), arthritis (28.9 %), diabetes (21.8 %), and cancer (14.7 %). Majority of participants perceived high blood pressure, high blood cholesterol, and diabetes to be a concern in their community, and had high awareness of the risk factors associated with these diseases. Reported rates of hypertension, high cholesterol, and diabetes suggest that lifestyle interventions targeting diet and physical activity, in addition to health education, are needed in this population.

  12. Treating relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia: liposome-encapsulated vincristine.

    PubMed

    Davis, Tyler; Farag, Sherif S

    2013-01-01

    Acute lymphoblastic leukemia (ALL) remains a disease with poor outcomes in adults. While induction chemotherapy achieves a complete remission in almost 90% of patients, the majority will relapse and die of their disease. Relapsed ALL is associated with a high reinduction mortality and chemotherapy resistance, with allogeneic hematopoietic stem cell transplantation offering the only therapy with curative potential. However, there is no efficacious and well tolerated standard regimen accepted as a "bridge" to allogeneic stem cell transplantation or as definitive treatment for patients who are not transplant candidates. Vincristine is an active drug in patients with ALL, but its dose intensity is limited by neurotoxicity, and its full potential as an anticancer drug is thus not realized. Encapsulation of vincristine into sphingomyelin and cholesterol nanoparticle liposomes facilitates dose-intensification and densification to enhanced target tissues with reduced potential for toxicity. Vincristine sulfate liposome injection (VSLI) is associated with significant responses in clinically advanced ALL, and has recently been approved by the US Food and Drug Administration for treatment of relapsed and clinically advanced Philadelphia chromosome-negative ALL. This review provides an overview of the preclinical and clinical studies leading to the approval of VSLI for the treatment of relapsed and refractory ALL, and suggests potential areas of future clinical development.

  13. Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia.

    PubMed

    Leonard, Jessica T; Rowley, Joelle S J; Eide, Christopher A; Traer, Elie; Hayes-Lattin, Brandon; Loriaux, Marc; Spurgeon, Stephen E; Druker, Brian J; Tyner, Jeffrey W; Chang, Bill H

    2016-08-31

    Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+)ALL) remains a challenge. Although the addition of targeted tyrosine kinase inhibitors (TKIs) to standard cytotoxic therapy has greatly improved upfront treatment, treatment-related morbidity and mortality remain high. TKI monotherapy provides only temporary responses and renders patients susceptible to the development of TKI resistance. Thus, identifying agents that could enhance the activity of TKIs is urgently needed. Recently, a selective inhibitor of B cell lymphoma 2 (BCL-2), ABT-199 (venetoclax), has shown impressive activity against hematologic malignancies. We demonstrate that the combination of TKIs with venetoclax is highly synergistic in vitro, decreasing cell viability and inducing apoptosis in Ph(+)ALL. Furthermore, the multikinase inhibitors dasatinib and ponatinib appear to have the added advantage of inducing Lck/Yes novel tyrosine kinase (LYN)-mediated proapoptotic BCL-2-like protein 11 (BIM) expression and inhibiting up-regulation of antiapoptotic myeloid cell leukemia 1 (MCL-1), thereby potentially overcoming the development of venetoclax resistance. Evaluation of the dasatinib-venetoclax combination for the treatment of primary Ph(+)ALL patient samples in xenografted immunodeficient mice confirmed the tolerability of this drug combination and demonstrated its superior antileukemic efficacy compared to either agent alone. These data suggest that the combination of dasatinib and venetoclax has the potential to improve the treatment of Ph(+)ALL and should be further evaluated for patient care.

  14. The Impact of Variant Philadelphia Chromosome Translocations on the Clinical Course of Chronic Myeloid Leukemia.

    PubMed

    Eyüpoğlu, Damla; Bozkurt, Süreyya; Haznedaroğlu, İbrahim; Büyükaşık, Yahya; Güven, Deniz

    2016-03-05

    Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22) with the formation of Philadelphia (Ph) chromosome. Sometimes, the Ph translocation is generated by variant rearrangements. The prognostic impact of the variant translocations is still controversial. Among the 180 patients with Ph-positive CML who were treated in Hacettepe University Faculty of Medicine Division of Hematology, variant translocations were detected, and retrospectively clinical and prognostic features were described. Also we performed a comprehensive literature review on the prognosis of such variant cases before and after tyrosine kinase inhibitor era. Five patients (2.7%) had variant Ph chromosomes, involved in the rearrangements were chromosomes 2 (2 cases), 11, 14 and 15. Patients were treated with imatinib or dasatinib. All patients reached a stable major molecular response suggesting a prognosis not worse than standard translocation individuals. Our present data were compatible with the data of previous studies indicating no difference in the prognosis between standard and variant translocations in tyrosine kinase inhibitors era of CML.

  15. Secondary Philadelphia chromosome and erythrophagocytosis in a relapsed acute myeloid leukemia after hematopoietic cell transplantation.

    PubMed

    Kelemen, Katalin; Galani, Komal; Conley, Christopher R; Greipp, Patricia T

    2014-06-01

    The acquisition of the Philadelphia chromosome (Ph) as a secondary change during the course of hematopoietic malignancies is rare and is associated with poor prognosis. Few cases of secondary Ph have been reported after hematopoietic cell transplantation (HCT). A secondary Ph at relapse is of clinical importance because it provides a therapeutic target for tyrosine kinase inhibitors along with or in replacement of chemotherapy. We describe a case of relapsed acute myeloid leukemia (AML) after HCT that developed a BCR-ABL1 translocation along with erythrophagocytosis by blasts as a secondary change at the time of relapse. The progression of this patient's myeloid neoplasm from myelodysplastic syndrome to AML to relapsed AML after HCT was accompanied by a stepwise cytogenetic evolution: A deletion 20q abnormality subsequently acquired a deletion 7q and, finally, at relapse after HCT, a secondary Ph was gained. The relationship between the secondary Ph and the erythrophagocytosis by blasts is not clear. We review the possible pathogenesis and cytogenetic associations of erythrophagocytosis by blasts, a rare feature in acute leukemias.

  16. Abrupt evolution of Philadelphia chromosome-positive acute myeloid leukemia in myelodysplastic syndrome.

    PubMed

    Fukunaga, Akiko; Sakoda, Hiroto; Iwamoto, Yoshihiro; Inano, Shojiro; Sueki, Yuki; Yanagida, Soshi; Arima, Nobuyoshi

    2013-03-01

    Myelodysplastic syndrome (MDS) is a clonal disorder arising from an alteration in multipotent stem cells, which lose the ability of normal proliferation and differentiation. Disease progression occurs in approximately 30% MDS cases. Specific chromosomal alterations seem responsible for each step in the evolution of acute myeloid leukemia (AML). Multiple genetic aberrations occur during the clonal evolution of MDS; however, few studies report the presence of the Philadelphia (Ph) chromosome. We report a rare case of Ph-positive AML, which evolved during the course of low-risk MDS. The patient, a 76-year-old man with mild leukocytopenia, was diagnosed with MDS, refractory neutropenia (RN). After 1.5 yr, his peripheral blood and bone marrow were suddenly occupied by immature basophils and myeloblasts, indicating the onset of AML. A bone marrow smear showed multilineage dysplasia, consistent with MDS evolution. Chromosomal analysis showed an additional t(9;22)(q34;q11) translocation. Because progression occurred concurrently with emergence of the Ph chromosome, we diagnosed this case as Ph-positive AML with basophilia arising from the clonal evolution of MDS. The patient was initially treated with nilotinib. A hematological response was soon achieved with disappearance of the Ph chromosome in the bone marrow. Emergence of Ph-positive AML in the course of low-risk MDS has rarely been reported. We report this case as a rare clinical course of MDS.

  17. Combination therapy with copanlisib and ABL tyrosine kinase inhibitors against Philadelphia chromosome-positive resistant cells

    PubMed Central

    Okabe, Seiichi; Tauchi, Tetsuzo; Tanaka, Yuko; Sakuta, Juri; Ohyashiki, Kazuma

    2016-01-01

    ABL tyrosine kinase inhibitor (TKI) therapy has improved the survival of patients with Philadelphia (Ph) chromosome-positive leukemia. However, ABL TKIs cannot eradicate leukemia stem cells. Therefore, new therapeutic approaches for Ph-positive leukemia are needed. Aberrant activation of phosphoinositide 3-kinase (PI3K) signaling is important for the initiation and maintenance of human cancers. Copanlisib (BAY80-6946) is a potent inhibitor of PI3Kα and PI3K-δ. Here we investigated the efficacy of combination therapy of copanlisib with an ABL TKI (imatinib, nilotinib, or ponatinib) using BCR-ABL-positive cells. Although the effects of the ABL TKI treatment were reduced in the presence of the feeder cell line, HS-5, copanlisib inhibited cell growth. Upon combining ABL TKI and copanlisib, cell growth was reduced. Ponatinib and copanlisib combined therapy reduced tumor volume and increased survival in mouse allograft models, respectively. These results indicate that the PI3Kα and -δ inhibitors overcame the chemoprotective effects of the feeder cells and enhanced ABL TKI cytotoxicity. Thus, co-treatment with ABL TKI and copanlisib may be a powerful strategy against ABL TKI-resistant cells, including those harboring the related T315I mutation. PMID:27437766

  18. Combination therapy with copanlisib and ABL tyrosine kinase inhibitors against Philadelphia chromosome-positive resistant cells.

    PubMed

    Okabe, Seiichi; Tauchi, Tetsuzo; Tanaka, Yuko; Sakuta, Juri; Ohyashiki, Kazuma

    2016-08-16

    ABL tyrosine kinase inhibitor (TKI) therapy has improved the survival of patients with Philadelphia (Ph) chromosome-positive leukemia. However, ABL TKIs cannot eradicate leukemia stem cells. Therefore, new therapeutic approaches for Ph-positive leukemia are needed. Aberrant activation of phosphoinositide 3-kinase (PI3K) signaling is important for the initiation and maintenance of human cancers. Copanlisib (BAY80-6946) is a potent inhibitor of PI3Kα and PI3K-δ. Here we investigated the efficacy of combination therapy of copanlisib with an ABL TKI (imatinib, nilotinib, or ponatinib) using BCR-ABL-positive cells. Although the effects of the ABL TKI treatment were reduced in the presence of the feeder cell line, HS-5, copanlisib inhibited cell growth. Upon combining ABL TKI and copanlisib, cell growth was reduced. Ponatinib and copanlisib combined therapy reduced tumor volume and increased survival in mouse allograft models, respectively. These results indicate that the PI3Kα and -δ inhibitors overcame the chemoprotective effects of the feeder cells and enhanced ABL TKI cytotoxicity. Thus, co-treatment with ABL TKI and copanlisib may be a powerful strategy against ABL TKI-resistant cells, including those harboring the related T315I mutation.

  19. African American community leaders' policy recommendations for reducing racial disparities in HIV infection, treatment and care: results from a community-based participatory research project in Philadelphia, PA

    PubMed Central

    Nunn, Amy; Sanders, Julia; Carson, Lee; Thomas, Gladys; Cornwall, Alexandra; Towey, Caitlin; Lee, Hwajin; Tasco, Marian; Shabazz-El, Waheedah; Yolken, Annajane; Smith, Tyrone; Bell, Gary; Feller, Sophie; Smith, Erin; James, George; Dunston, Brenda Shelton; Green, Derek

    2015-01-01

    African Americans account for 45% of new HIV infections in the United States. Little empirical research investigates African American community leaders' normative recommendations for addressing these disparities. Philadelphia's HIV infection rate is five times the national average, nearly 70% of new infections are among African Americans, and 2% of African Americans in Philadelphia are living with HIV/AIDS. Using a community-based participatory research (CBPR) approach, we convened focus groups among 52 African American community leaders from diverse backgrounds to solicit normative recommendations for reducing Philadelphia's racial disparities in HIV infection. Leaders recommended: 1) Philadelphia's city government should raise awareness about HIV/AIDS with media campaigns featuring local leaders; 2) Local HIV prevention interventions should address social and structural factors influencing HIV risks rather than focus exclusively on mode of HIV transmission; 3) Resources should be distributed to the most heavily impacted neighborhoods of Philadelphia; and 4) Faith institutions should play a critical role in HIV testing, treatment and prevention efforts. We developed a policy memo highlighting these normative recommendations for how to enhance local HIV prevention policy. This policy memo led to Philadelphia City Council hearings about HIV/AIDS in October 2010 and subsequently informed local HIV/AIDS prevention policy and development of local HIV prevention interventions. This CBPR case study offers important lessons for effectively engaging community leaders in research to promote HIV/AIDS policy change. PMID:24879446

  20. Molecular Cytogenetics Investigation of the Telomeres in a Case of Philadelphia Positive B-ALL with a Single Telomere Expansion1

    PubMed Central

    Krejci, Katerina; Stentoft, Jesper; Koch, Jørn

    1999-01-01

    Abstract We have investigated a single telomere expansion in a case of acute lymphoblastic B-cell leukemia (B-ALL), where half of the cells in the bone marrow sample appeared with a Philadelphia chromosome. Comparing telomere sizes in Philadelphia-positive versus -negative cells, we found generally shorter telomeres in the Philadelphia-positive cells, but with an expansion of the telomere on the long arm of one chromosome 11 homologue. This expansion was also found in a minority of Philadelphia-negative cells. The telomeres in these cells were of the same overall size as the telomeres in the Philadelphia-negative cells without the 11q expansion. Together, these findings suggest that the order of events was: 11q telomere expansion, Philadelphia translocation, overall telomere shortening. The expanded 11q telomere contained the standard telomeric (AGGGTT)n repeat, but also variant repeat sequences. The single telomere expansion suggests a non-telomerase mechanism behind the expansion which may also explain the presence of variant repeats in the expanded telomere. The present case illustrates that telomere changes may occur at only some chromosome ends in a subset of cells. To reveal such changes, telomere morphology should be studied with in situ methodology. PMID:10935496

  1. African American community leaders' policy recommendations for reducing racial disparities in HIV infection, treatment, and care: results from a community-based participatory research project in Philadelphia, Pennsylvania.

    PubMed

    Nunn, Amy; Sanders, Julia; Carson, Lee; Thomas, Gladys; Cornwall, Alexandra; Towey, Caitlin; Lee, Hwajin; Tasco, Marian; Shabazz-El, Waheedah; Yolken, Annajane; Smith, Tyrone; Bell, Gary; Feller, Sophie; Smith, Erin; James, George; Shelton Dunston, Brenda; Green, Derek

    2015-01-01

    African Americans account for 45% of new HIV infections in the United States. Little empirical research investigates African American community leaders' normative recommendations for addressing these disparities. Philadelphia's HIV infection rate is 5 times the national average, nearly 70% of new infections are among African Americans, and 2% of African Americans in Philadelphia are living with HIV/AIDS. Using a community-based participatory research approach, we convened focus groups among 52 African American community leaders from diverse backgrounds to solicit normative recommendations for reducing Philadelphia's racial disparities in HIV infection. Leaders recommended that (a) Philadelphia's city government should raise awareness about HIV/AIDS with media campaigns featuring local leaders, (b) local HIV-prevention interventions should address social and structural factors influencing HIV risks rather than focus exclusively on mode of HIV transmission, (c) resources should be distributed to the most heavily affected neighborhoods of Philadelphia, and (d) faith institutions should play a critical role in HIV testing, treatment, and prevention efforts. We developed a policy memo highlighting these normative recommendations for how to enhance local HIV prevention policy. This policy memo led to Philadelphia City Council hearings about HIV/AIDS in October 2010 and subsequently informed local HIV/AIDS prevention policy and development of local HIV prevention interventions. This community-based participatory research case study offers important lessons for effectively engaging community leaders in research to promote HIV/AIDS policy change.

  2. Motivations for prescription drug misuse among young men who have sex with men (YMSM) in Philadelphia

    PubMed Central

    Kecojevic, Aleksandar; Corliss, Heather L.; Lankenau, Stephen E.

    2015-01-01

    Background Prescription drug misuse (i.e. opioids, tranquilizers and stimulants) has become the fastest growing area of substance abuse among young adults. Limited studies focus on prescription drug misuse among young men who have sex with men (YMSM, aged 18–29 years). Furthermore, little is known about YMSM’s motivations for misuse. The purpose of this study was to explore personal motivations for prescription drug misuse among YMSM, including the possible connection between misuse and sexual behaviors. Methods As part of a larger mixed methods study of 191 YMSM recruited in Philadelphia during 2012–2013, we conducted semi-structured qualitative interviews with 25 of these participants to gather additional contextual information about their prescription drug misuse. We conducted thematic analysis of qualitative data. Results While our results corroborated previous literature on motives for misuse of prescription drugs, our data yielded some distinct motivations specific among YMSM. These motives included social/recreational motives, facilitating sex with other men (including motives such as use of opioids for less painful anal receptive sex), and psychological motives such as depression, stress management, coping with everyday hardships (opioids and tranquilizers) or feeling more energized (stimulants). Prescription drugs were commonly misused within the broader contexts of participants' polysubstance use, adding to the significance of this problem. Conclusions Our findings offer insights into YMSM’s motivations for prescription drug misuse, and point to the importance of recognizing and addressing them. While substance use is likely related to various psychosocial issues impacting YMSM, it also may lead to significant health consequences. Results support the need to include prescription drugs and polysubstance use in harm reduction messages and treatment approaches aimed at substance using YMSM. PMID:25936445

  3. Concentration of Tobacco Advertisements at SNAP and WIC Stores, Philadelphia, Pennsylvania, 2012

    PubMed Central

    Chilton, Mariana; Zhao, Qian-Wei; Szymkowiak, Dorota; Coffman, Ryan; Mallya, Giridhar

    2015-01-01

    Introduction Tobacco advertising is widespread in urban areas with racial/ethnic minority and low-income households that participate in nutrition assistance programs. Tobacco sales and advertising are linked to smoking behavior, which may complicate matters for low-income families struggling with disparate health risks relating to nutrition and chronic disease. We investigated the relationship between the amount and type of tobacco advertisements on tobacco outlets and the outlet type and location. Methods By using field visits and online images, we inspected all licensed tobacco retail outlets in Philadelphia (N = 4,639). Point pattern analyses were used to identify significant clustering of tobacco outlets and outlets with exterior tobacco advertisements. Logistic regression was used to analyze the relationship between the outlet’s acceptance of Supplemental Nutrition Assistance Program (SNAP) and Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and the presence of tobacco advertisements. Results Tobacco outlets with exterior tobacco advertisements were significantly clustered in several high-poverty areas. Controlling for racial/ethnic and income composition and land use, SNAP and WIC vendors were significantly more likely to have exterior (SNAP odds ratio [OR], 2.11; WIC OR, 1.59) and interior (SNAP OR, 3.43; WIC OR, 1.69) tobacco advertisements than other types of tobacco outlets. Conclusion Tobacco advertising is widespread at retail outlets, particularly in low-income and racial/ethnic minority neighborhoods. Policy makers may be able to mitigate the effects of this disparate exposure through tobacco retail licensing, local sign control rules, and SNAP and WIC authorization. PMID:25654220

  4. Philadelphia chromosome-positive leukemia stem cells in acute lymphoblastic leukemia and tyrosine kinase inhibitor therapy.

    PubMed

    Thomas, Xavier

    2012-06-26

    Leukemia stem cells (LSCs), which constitute a minority of the tumor bulk, are functionally defined on the basis of their ability to transfer leukemia into an immunodeficient recipient animal. The presence of LSCs has been demonstrated in acute lymphoblastic leukemia (ALL), of which ALL with Philadelphia chromosome-positive (Ph(+)). The use of imatinib, a tyrosine kinase inhibitor (TKI), as part of front-line treatment and in combination with cytotoxic agents, has greatly improved the proportions of complete response and molecular remission and the overall outcome in adults with newly diagnosed Ph(+) ALL. New challenges have emerged with respect to induction of resistance to imatinib via Abelson tyrosine kinase mutations. An important recent addition to the arsenal against Ph(+) leukemias in general was the development of novel TKIs, such as nilotinib and dasatinib. However, in vitro experiments have suggested that TKIs have an antiproliferative but not an antiapoptotic or cytotoxic effect on the most primitive ALL stem cells. None of the TKIs in clinical use target the LSC. Second generation TKI dasatinib has been shown to have a more profound effect on the stem cell compartment but the drug was still unable to kill the most primitive LSCs. Allogeneic stem cell transplantation (SCT) remains the only curative treatment available for these patients. Several mechanisms were proposed to explain the resistance of LSCs to TKIs in addition to mutations. Hence, TKIs may be used as a bridge to SCT rather than monotherapy or combination with standard chemotherapy. Better understanding the biology of Ph(+) ALL will open new avenues for effective management. In this review, we highlight recent findings relating to the question of LSCs in Ph(+) ALL.

  5. Black carbon concentrations in a goods-movement neighborhood of Philadelphia, PA.

    PubMed

    Kondo, Michelle C; Mizes, Chris; Lee, John; Burstyn, Igor

    2014-07-01

    Communities along the Delaware River in Philadelphia, USA such as Port Richmond, are subject to traffic associated with goods movement to and from port facilities and local industry. Air pollution associated with this traffic poses an environmental health concern in this and other urban areas. Our study measures black carbon (BC) in Port Richmond and examines its relationship to expected sources such as truck traffic. We used a participatory sampling method to conduct 1-min measurements over 8-hour periods at 14 homes, a school and park, during a 4-week period in June 2012. Measurements over 9 sampling days had a 30-min average BC concentration of 1.2 μg m(-3), and a maximum of 12 μg m(-3). Statistical analyses showed some effect of traffic, but greater association between BC concentrations and weather and time of day. BC concentrations varied more by location than by day, and distance to traffic arterials and interstate freeway was a predictor of this variance. While our dataset is limited by number and variety of observations, major findings indicate that BC concentration varies more by location than by day, there is a decrease in median BC concentration with increased distance from an interstate highway, and an expected effect of diesel traffic on average daily BC concentrations. Our findings are an important step towards understanding patterns and determinants of BC concentration in communities colocated with major ports. Our study also demonstrates that participatory methods in air pollution monitoring can help increase awareness of local air pollution levels.

  6. Philadelphia-Negative Classical Myeloproliferative Neoplasms: Critical Concepts and Management Recommendations From European LeukemiaNet

    PubMed Central

    Barbui, Tiziano; Barosi, Giovanni; Birgegard, Gunnar; Cervantes, Francisco; Finazzi, Guido; Griesshammer, Martin; Harrison, Claire; Hasselbalch, Hans Carl; Hehlmann, Rudiger; Hoffman, Ronald; Kiladjian, Jean-Jacques; Kröger, Nicolaus; Mesa, Ruben; McMullin, Mary F.; Pardanani, Animesh; Passamonti, Francesco; Vannucchi, Alessandro M.; Reiter, Andreas; Silver, Richard T.; Verstovsek, Srdan; Tefferi, Ayalew

    2011-01-01

    We present a review of critical concepts and produce recommendations on the management of Philadelphia-negative classical myeloproliferative neoplasms, including monitoring, response definition, first- and second-line therapy, and therapy for special issues. Key questions were selected according the criterion of clinical relevance. Statements were produced using a Delphi process, and two consensus conferences involving a panel of 21 experts appointed by the European LeukemiaNet (ELN) were convened. Patients with polycythemia vera (PV) and essential thrombocythemia (ET) should be defined as high risk if age is greater than 60 years or there is a history of previous thrombosis. Risk stratification in primary myelofibrosis (PMF) should start with the International Prognostic Scoring System (IPSS) for newly diagnosed patients and dynamic IPSS for patients being seen during their disease course, with the addition of cytogenetics evaluation and transfusion status. High-risk patients with PV should be managed with phlebotomy, low-dose aspirin, and cytoreduction, with either hydroxyurea or interferon at any age. High-risk patients with ET should be managed with cytoreduction, using hydroxyurea at any age. Monitoring response in PV and ET should use the ELN clinicohematologic criteria. Corticosteroids, androgens, erythropoiesis-stimulating agents, and immunomodulators are recommended to treat anemia of PMF, whereas hydroxyurea is the first-line treatment of PMF-associated splenomegaly. Indications for splenectomy include symptomatic portal hypertension, drug-refractory painful splenomegaly, and frequent RBC transfusions. The risk of allogeneic stem-cell transplantation–related complications is justified in transplantation-eligible patients whose median survival time is expected to be less than 5 years. PMID:21205761

  7. Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia.

    PubMed

    Kim, Dae-Young; Joo, Young-Don; Lim, Sung-Nam; Kim, Sung-Doo; Lee, Jung-Hee; Lee, Je-Hwan; Kim, Dong Hwan Dennis; Kim, Kihyun; Jung, Chul Won; Kim, Inho; Yoon, Sung-Soo; Park, Seonyang; Ahn, Jae-Sook; Yang, Deok-Hwan; Lee, Je-Jung; Lee, Ho-Sup; Kim, Yang Soo; Mun, Yeung-Chul; Kim, Hawk; Park, Jae Hoo; Moon, Joon Ho; Sohn, Sang Kyun; Lee, Sang Min; Lee, Won Sik; Kim, Kyoung Ha; Won, Jong-Ho; Hyun, Myung Soo; Park, Jinny; Lee, Jae Hoon; Shin, Ho-Jin; Chung, Joo-Seop; Lee, Hyewon; Eom, Hyeon-Seok; Lee, Gyeong Won; Cho, Young-Uk; Jang, Seongsoo; Park, Chan-Jeoung; Chi, Hyun-Sook; Lee, Kyoo-Hyung

    2015-08-06

    We investigated the effects of nilotinib plus multiagent chemotherapy, followed by consolidation/maintenance or allogeneic hematopoietic cell transplantation (allo-HCT) for adult patients with newly diagnosed Philadelphia-positive (Ph-pos) acute lymphoblastic leukemia (ALL). Study subjects received induction treatment that comprised concurrent vincristine, daunorubicin, prednisolone, and nilotinib. After achieving complete hematologic remission (HCR), subjects received either 5 courses of consolidation, followed by 2-year maintenance with nilotinib, or allo-HCT. Minimal residual disease (MRD) was assessed at HCR, and every 3 months thereafter. The molecular responses (MRs) were defined as MR3 for BCR-ABL1/G6PDH ratios ≤10(-3) and MR5 for ratios <10(-5). Ninety evaluable subjects, ages 17 to 71 years, were enrolled in 17 centers. The HCR rate was 91%; 57 subjects received allo-HCT. The cumulative MR5 rate was 94%; the 2-year hematologic relapse-free survival (HRFS) rate was 72% for 82 subjects that achieved HCR, and the 2-year overall survival rate was 72%. Subjects that failed to achieve MR3 or MR5 were 9.1 times (P = .004) or 6.3 times (P = .001) more prone to hematologic relapse, respectively, than those that achieved MR3 or MR5. MRD statuses just before allo-HCT and at 3 months after allo-HCT were predictive of 2-year HRFS. Adverse events occurred mainly during induction, and most were reversible with dose reduction or transient interruption of nilotinib. The combination of nilotinib with high-dose cytotoxic drugs was feasible, and it effectively achieved high cumulative complete molecular remission and HRFS rates. The MRD status at early postremission time was predictive of the HRFS. This trial was registered at www.clinicaltrials.gov as #NCT00844298.

  8. Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome–positive ALL

    PubMed Central

    Coudé, Marie Magdelaine; Gokbuget, Nicola; Gambacorti Passerini, Carlo; Hayette, Sandrine; Cayuela, Jean-Michel; Huguet, Françoise; Leguay, Thibaut; Chevallier, Patrice; Salanoubat, Celia; Bonmati, Caroline; Alexis, Magda; Hunault, Mathilde; Glaisner, Sylvie; Agape, Philippe; Berthou, Christian; Jourdan, Eric; Fernandes, José; Sutton, Laurent; Banos, Anne; Reman, Oumedaly; Lioure, Bruno; Thomas, Xavier; Ifrah, Norbert; Lafage-Pochitaloff, Marina; Bornand, Anne; Morisset, Laure; Robin, Valérie; Pfeifer, Heike; Delannoy, Andre; Ribera, Josep; Bassan, Renato; Delord, Marc; Hoelzer, Dieter; Dombret, Herve; Ottmann, Oliver G.

    2016-01-01

    Prognosis of Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) in the elderly has improved during the imatinib era. We investigated dasatinib, another potent tyrosine kinase inhibitor, in combination with low-intensity chemotherapy. Patients older than age 55 years were included in the European Working Group on Adult ALL (EWALL) study number 01 for Ph+ ALL (EWALL-PH-01 international study) and were treated with dasatinib 140 mg/day (100 mg/day over 70 years) with intrathecal chemotherapy, vincristine, and dexamethasone during induction. Patients in complete remission continued consolidation with dasatinib, sequentially with cytarabine, asparaginase, and methotrexate for 6 months. Maintenance therapy was dasatinib and vincristine/dexamethasone reinductions for 18 months followed by dasatinib until relapse or death. Seventy-one patients with a median age of 69 years were enrolled; 77% had a high comorbidity score. Complete remission rate was 96% and 65% of patients achieved a 3-log reduction in BCR-ABL1 transcript levels during consolidation. Only 7 patients underwent allogeneic hematopoietic stem cell transplantation. At 5 years, overall survival was 36% and up to 45% taking into account deaths unrelated to disease or treatment as competitors. Thirty-six patients relapsed, 24 were tested for mutation by Sanger sequencing, and 75% were T315I-positive. BCR-ABL1T315I was tested by allele-specific oligonucleotide reverse transcription–quantitative polymerase chain reaction in 43 patients and detection was associated with short-term relapses. Ten patients (23%) were positive before any therapy and 8 relapsed, all with this mutation. In conclusion, dasatinib combined with low-intensity chemotherapy was well-tolerated and gave long-term survival in 36% of elderly patients with Ph+ ALL. Monitoring of BCR-ABL1T315I from diagnosis identified patients with at high risk of early relapse and may help to personalize therapy. PMID:27121472

  9. Survival implications of molecular heterogeneity in variant Philadelphia-positive chronic myeloid leukaemia.

    PubMed

    Reid, Alistair G; Huntly, Brian J P; Grace, Colin; Green, Anthony R; Nacheva, Elisabeth P

    2003-05-01

    The BCR-ABL fusion in chronic myeloid leukaemia (CML) is generated by the Philadelphia (Ph) translocation t(9;22) or, in 10% of patients, variants thereof (vPh). Deletion encompassing the reciprocal product (ABL-BCR) from the derivative chromosome 9 [der(9)] occurs in 15% of all patients, but with greater frequency in vPh patients. Reports of physical separation of ABL-BCR in non-deleted patients, as well as evolution from classical to variant Ph, introduce further heterogeneity to the vPh subgroup and raise the possibility that such translocations may herald disease progression. Survival analyses, however, have thus far yielded contradictory results. We assessed the frequency of der(9) deletions, ABL-BCR abrogation, cytogenetic evolution and cryptic rearrangement in a large cohort of 54 patients with vPh CML. Deletions encompassing ABL-BCR were detected in 37% of patients, consistent with a model in which a greater number of chromosome breaks increases the risk of genomic loss. The components of ABL-BCR were physically separated in a further 52% of patients while fused in the remaining 11%. Evolution from classical to vPh was demonstrated in three patients. The difference in survival, as indicated by Kaplan-Meier analysis, was marked between classical and vPh patients (105 vs 60 months respectively; P = 0.0002). Importantly, this difference disappeared when patients with deletions were removed from the analysis. Our study showed that, despite the existence of several levels of genomic heterogeneity in variant Ph-positive CML, der(9) deletion status is the key prognostic factor.

  10. Cost and effectiveness of an eye care adherence program for Philadelphia children with significant visual impairment.

    PubMed

    Pizzi, Laura T; Snitzer, Melanie; Amos, Tony; Prioli, Katherine M; Steele, Deon; Levin, Alex V

    2015-06-01

    The follow-up rate among children with vision problems in the authors' outreach programs has been <5%. The authors therefore developed a social worker (SW) intervention, the Children's Eye Care Adherence Program (CECAP), for Philadelphia school children. The objective of this study was to measure CECAP's effectiveness and cost, as well as to identify barriers to care through a conceptual framework and geomapping software. A SW reviewed records to identify children needing follow-up and phoned families to identify and resolve barriers to eye care and scheduled appointments. Effectiveness was defined as the percent completing ≥ 1 follow-up visit within the physician-recommended time frame. Cost was measured for SW time (SW wage rates+benefits) and additional materials (forms, postage, phone charges). Barriers were organized into a conceptual framework depicting predisposing factors, system factors, and financial factors. Geomapping software was used to illustrate follow-up rates. In all, 120 patients required additional pediatric ophthalmic care; 71 patients were contacted and returned for care (59.2%); 49 patients were contacted but did not return (40.8%). SW time was 3h rs/patient for those who returned and 2 hrs/patient for those who did not return. Based on the CECAP program total cost ($14,249) and the reimbursement payment ($6265.66), the net cost of the CECAP program was $7983.59. Predisposing factors were the primary barrier theme for patients who did not follow up. CECAP significantly improved adherence to eye care but comes at an additional cost. Future efforts should focus on reducing operational efficiencies and targeting CECAP based on predictors of follow-up.

  11. Current treatment options for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

    PubMed

    Stock, Wendy

    2010-02-01

    The clinical management of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has been challenging primarily due to the aggressive nature of the disease and limited effective treatment options. The outcome for patients who receive conventional chemotherapy alone is poor, with remission duration of around 12 months and disease-free survival (DFS) rates of not more than 10%. Allogeneic stem cell transplantation (alloSCT) has been the only known curative treatment option, but is limited by the availability of a matched donor and the risk of treatment-related mortality. Given the role of BCR-ABL in the leukemogenesis of Ph+ ALL, current treatments have focused on inhibition of this oncogenic tyrosine kinase. Early studies demonstrate that the use of the BCR-ABL tyrosine kinase inhibitor (TKI), imatinib, before alloSCT results in improved response rates and DFS when combined with standard chemotherapy regimens. Remission duration also is improved when combination chemotherapy and imatinib are administered intensively, even in the absence of allogeneic stem cell transplant. However, resistant disease remains an important problem, and the mechanisms underlying resistance in Ph+ ALL are multifactorial. Novel TKIs are currently under development and are effective in some patients with imatinib-resistant disease. The dual BCR-ABL/SRC family kinase inhibitor, dasatinib, has shown promising activity in the treatment of Ph+ ALL after imatinib failure and has recently been approved in this indication. Other TKI-based therapies are also showing potential in imatinib-resistant disease. This article reviews current and emerging treatments in Ph+ ALL.

  12. Primary Prevention of Lead Exposure: The Philadelphia Lead Safe Homes Study

    PubMed Central

    Campbell, Carla; Tran, Mary; Gracely, Edward; Starkey, Naomi; Kersten, Hans; Palermo, Peter; Rothman, Nancy; Line, Laura; Hansen-Turton, Tine

    2011-01-01

    Objective Lead exposure in children can lead to neuropsychological impairment. This study tested whether primary prevention interventions in the newborn period prevent elevated blood lead levels (BLLs). Methods The Philadelphia Lead Safe Homes (LSH) Study offered parental education, home evaluation, and lead remediation to the families of urban newborns. Households were randomized to a standard lead education group or maintenance education group. We conducted home visits at baseline, six months, and 12 months. To compare BLLs, we identified a matched comparison group. Results We enrolled and randomized 314 newborns in the intervention component; 110 completed the study. There were few significant differences between the randomized groups. In the combined intervention groups, positive results on visual inspection declined from baseline to 12 months (97.0% to 90.6%, p=0.007). At baseline, 36.9% of homes were above the U.S. Environmental Protection Agency's lead dust standard, compared with 26.9% at 12 months (p=0.032), mainly due to a drop in windowsill dust levels. Both groups showed a significant increase in parental scores on a lead education test. Children in the intervention and matched control groups had similar geometric mean initial BLLs (2.6 vs. 2.7, p=0.477), but a significantly higher percentage of children in the intervention group had an initial blood lead screening compared with those in the matched group (88.9% vs. 84.4%, p=0.032). Conclusions A study of primary prevention of lead exposure showed a higher blood lead screening rate for the combined intervention groups and mean BLLs at one year of age not statistically different from the comparison group. Most homes had lead hazards. Lead education significantly increased knowledge. PMID:21563715

  13. Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

    PubMed Central

    Piñana, José Luis; Sanz, Jaime; Picardi, Alessandra; Ferrá, Christelle; Martino, Rodrigo; Barba, Pere; Gonzalez-Vicent, Marta; Pascual, María Jesús; Martín, Carmen; Verdeguer, Amparo; de Heredia, Cristina Diaz; Montesinos, Pau; Ribera, José-María; Sanz, Miguel; Arcese, William; Sanz, Guillermo

    2014-01-01

    There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation from unrelated donors within the GETH/GITMO cooperative group. Conditioning regimens were based on combinations of thiotepa, busulfan, cyclophospamide or fludarabine, and antithymocyte globulin. At the time of transplantation, 35 patients (78%) were in first complete remission, four (8%) in second complete remission and six (14%) in third or subsequent response. The cumulative incidence of myeloid engraftment was 96% at a median time of 20 days and significantly better for patients receiving higher doses of CD34+ cells. The incidence of acute grade II–IV graft-versus-host disease was 31%, while that of overall chronic graft-versus-host disease was 53%. Treatment-related mortality was 17% at day +100 and 31% at 5 years. The 5-year relapse, event-free survival and overall survival rates were 31%, 36% and 44%, respectively. Although the event-free and overall survival rates in patients without BCR/ABL transcripts detectable at time of transplant were better than those in whom BCR/ABL transcripts were detected (46% versus 24% and 60% versus 30%, respectively) these differences were not statistically significant in the univariate analysis (P=0.07). These results demonstrate that umbilical cord blood transplantation from unrelated donors can be a curative treatment for a substantial number of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. PMID:24097633

  14. Otto Rank, the Rankian circle in Philadelphia, and the origins of Carl Rogers' person-centered psychotherapy.

    PubMed

    deCarvalho, R J

    1999-05-01

    Otto Rank's will therapy helped shape the ideas and techniques of relationship therapy developed by the Philadelphia social workers Jessie Taft, Virginia Robinson, and Frederick Allen in the 1930s. Rank's work and these ideas and techniques in turn strongly influenced the formulation of Carl Rogers' person-centered psychotherapy. This article compares and contrasts will, relationship, and person-centered approaches to psychotherapy and discusses the social factors--primarily the professional conflicts between a male-dominated psychiatry and female social workers over the independent practice of psychotherapy--that were crucial in the dissemination of Rank's psychological thought and the early popularity of Rogers.

  15. The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth.

    PubMed

    Satterthwaite, Theodore D; Connolly, John J; Ruparel, Kosha; Calkins, Monica E; Jackson, Chad; Elliott, Mark A; Roalf, David R; Ryan Hopsona, Karthik Prabhakaran; Behr, Meckenzie; Qiu, Haijun; Mentch, Frank D; Chiavacci, Rosetta; Sleiman, Patrick M A; Gur, Ruben C; Hakonarson, Hakon; Gur, Raquel E

    2016-01-01

    The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale study of child development that combines neuroimaging, diverse clinical and cognitive phenotypes, and genomics. Data from this rich resource is now publicly available through the Database of Genotypes and Phenotypes (dbGaP). Here we focus on the data from the PNC that is available through dbGaP and describe how users can access this data, which is evolving to be a significant resource for the broader neuroscience community for studies of normal and abnormal neurodevelopment.

  16. The development of pediatric critical care medicine at The Children's Hospital of Philadelphia: an interview with Dr. John J. 'Jack' Downes.

    PubMed

    Mai, Christine L; Schreiner, Mark S; Firth, Paul G; Yaster, Myron

    2013-07-01

    Dr. John J. 'Jack' Downes (1930-), the anesthesiologist-in-chief at The Children's Hospital of Philadelphia (1972-1996), has made numerous contributions to pediatric anesthesia and critical care medicine through a broad spectrum of research on chronic respiratory failure, status asthmaticus, postoperative risks of apnea in premature infants, and home-assisted mechanical ventilation. However, his defining moment was in January 1967, when The Children's Hospital of Philadelphia inaugurated its pediatric intensive care unit--the first of its kind in North America. During his tenure, he and his colleagues trained an entire generation of pediatric anesthesiologists and intensivists and set a standard of care and professionalism that continues to the present day. Based on an interview with Dr. Downes, this article reviews a career that advanced pediatric anesthesia and critical care medicine and describes the development of that first pediatric intensive care unit at The Children's Hospital of Philadelphia.

  17. The effects of licensing and inspection enforcement to reduce tobacco sales to minors in Greater Philadelphia, 1994-1998.

    PubMed

    Ma, G X; Shive, S; Tracy, M

    2001-01-01

    This study examined the changes in tobacco sales to minors after active enforcement of merchant compliance to the Synar regulation and the city of Philadelphia Youth Access to Tobacco Ordinance 732. Data for the present study were obtained through Tobacco-free Education and Action Coalition for Health (TEACH) Program in a 5-year, follow-up retail compliance check survey of 1649 stores in 14 cluster areas of Philadelphia, PA. Trend analysis was conducted ofthe sales of tobacco to minors by type of retail outlet, gender, and age of the buyer, and gender, age, and race of the store clerk, and whether restriction policy signs were posted. Analysis indicates that there was a reduction in tobacco sales to minors after implementation of enforcement; sales dropped from 85% in 1994 to 43% in 1998. There were less sales to minors when signs were posted. There were differences in sales if the buyer was asked his or her age and whether the minor was asked to show identification. In addition, the age of the buyer and the brand of cigarettes were associated with sales. Future research should focus on both commercial and social availability and provision of tobacco to minors.

  18. A comparison of the prevalence of lead-contaminated imported Chinese ceramic dinnerware purchased inside versus outside Philadelphia's Chinatown.

    PubMed

    Gilmore, Thomas; O'Malley, Gerald F; Lau, Wayne Bond; Vann, David R; Bromberg, Adam; Martin, Aaron; Gibbons, Andrea; Rimmer, Evan

    2013-03-01

    Lead-contaminated ceramics can be a clinically significant source of lead poisoning, with the potential to cause illness in children and adults; one death in a child has been described. We hypothesized that the prevalence of lead-contaminated ceramics would be higher within Chinatown versus outside of Chinatown. The study was a prospective observational cross-sectional study. Two areas were defined geographically as being within and outside of Philadelphia's Chinatown, and a predefined number of items were purchased in each area. Each item was screened for lead utilizing a colorimetric testing swab. Positive items were leached for lead using the ASTM C738-94 protocol for lead level quantification. The primary outcome was the prevalence of ceramics not compliant with the FDA standard for leachable lead within and outside of Philadelphia's Chinatown. A total of 132 items were purchased, 46 outside of and 86 within Chinatown. More lead-positive items originated within Chinatown than outside of Chinatown [five positive items, 5.8 % prevalence within Chinatown (95 % confidence interval, CI, 2.5-12.9 %), and zero positive, 0 % prevalence outside of Chinatown (95 % CI 0-7.5 %)]. However, this difference was not found to be statistically significant (P = 0.1624). The leachable lead-positive items were up to 40-fold the acceptable FDA levels. Testing a larger number of items may demonstrate a significant source of lead exposure.

  19. National Commission on Libraries and Information Science Mid-Atlantic States Regional Hearing, Philadelphia, Pennsylvania, May 21, 1975. Volume Two. Written Testimony.

    ERIC Educational Resources Information Center

    National Commission on Libraries and Information Science, Washington, DC.

    This is the second of two volumes of written testimony presented to the National Commission on Libraries and Information Science (NCLIS) at its Mid-Atlantic States Regional Hearing held May 21, 1975 at Philadelphia, Pennsylvania. Statements are provided by academic, public, state, and special librarians, as well as by spokespersons for…

  20. Franklin's Philadelphia Academy and Basedow's Dessau Philanthropine: Two Models of Non-Denominational Schooling in Eighteenth-Century America and Germany

    ERIC Educational Resources Information Center

    Overhoff, Jurgen

    2007-01-01

    The Academy of Philadelphia (today known as the University of Pennsylvania), founded through Benjamin Franklin's influence in 1751, and the Dessau Philanthropine, founded by Johann Bernhard Basedow in 1774, were arguably the first non-denominational schools in the eighteenth century. Yet, the congenial educational ideas of their founders have…

  1. Needs and Potentialities Assessment of Asian-American Elderly in Greater Philadelphia. A Project of the Mid-Atlantic Region Research Committee.

    ERIC Educational Resources Information Center

    Peralta, Victorina; Horikawa, Herbert

    The study reported on in this document was undertaken to develop a service delivery model that would accurately reflect the Asian-American's specific cultural needs, values, and traditions. The personal characteristics, economic conditions, and interests of 255 Asian-American elderly in the Philadelphia area are described. A needs assessment of…

  2. A Description of Room Arrangement, Design, and Appearance in Title IV-A Day Care Centers in Philadelphia, 1974-1975. Report No. 7733.

    ERIC Educational Resources Information Center

    Silber, Theodore J.

    This report describes the room arrangement, design, and appearance of 152 Title IV-A Day Care centers in Philadelphia. A series of 27 items on a section of the Daily Care, In-Room Observation Guide was used to provide an overall description of rooms in day care and to identify differences in features for different types of programs. Data were…

  3. A Profile of Social Service Personnel in Title IV-A Day Care in Philadelphia, 1974-1975. Report No. 7646.

    ERIC Educational Resources Information Center

    Asano, Mildred M.

    This report, representing the first half of a comprehensive study, describes the personnel of the Social Services Component in Title IV-A Day Care in Philadelphia and discusses some of the functions and services provided by these personnel. Data were based on responses from 129 service workers in 38 agencies. Respondents reported information on 21…

  4. A Description of the Structure, Functions, and Services of the Title IV-A Social Services Component in Philadelphia, 1974-1975. Report No. 7660.

    ERIC Educational Resources Information Center

    Asano, Mildred M.

    This report, representing the second half of a comprehensive study, presents descriptive data on the structure, functions, and services of the Social Services Component in Title IV-A Day Care in Philadelphia. Data were based on extensive interviews with 67 respondents representing 35 agencies. Two interviews, one each with a supervisor and a…

  5. Report on Task Force Division of School Facilities, School District of Philadelphia: Commission to Investigate Relationships between Educational Performance and Size of Student Body, May 11, 1970.

    ERIC Educational Resources Information Center

    Philadelphia School District, PA.

    The Philadelphia Art Commission refused to approve the proposed Eastwick/Pepper Educational Complex that combines a high school and a middle school into one facility. Their rejection was based on (1) the prohibitively large numbers of children the school is to serve, (2) the overly broad age span of the students, and (3) the inadequate outside…

  6. Unlocking the Transformational Power of Continuing Education. Proceedings of the Annual Meeting of the Association for Continuing Higher Education (71st, Philadelphia, Pennsylvania, November 15-18, 2009)

    ERIC Educational Resources Information Center

    Jerman, Jerry, Ed.

    2009-01-01

    The 2009 proceedings of the Association for Continuing Higher Education represent the professional presentations of the keynote sessions, the concurrent sessions, and the business meeting of the association's 71st annual conference, held at the Sheraton Society Hill Hotel in Philadelphia on November 15-18, 2009. The conference provided an engaging…

  7. Evaluation of Safety Education (Choctaw Agency School System, Philadelphia, Mississippi, February 1976). Research and Evaluation Report Series No. 40.01.

    ERIC Educational Resources Information Center

    Lowry, Carlee S.

    Questionnaire responses derived from a sample of 202 Choctaw students (grades 4, 6, 8, and 10) in attendance at the Bureau of Indian Affairs' Choctaw Agency Schools (Philadelphia, Mississippi) were utilized to evaluate the Choctaw Safety Education Program. In addition, parents, teachers, janitors, bus drivers, council members, and principals were…

  8. Soaring to Excellence. Proceedings of the Annual North East Association for Institutional Research (NEAIR) Conference (33rd, Philadelphia, Pennsylvania, November 4-7, 2006)

    ERIC Educational Resources Information Center

    Alvord, Catherine, Ed.

    2006-01-01

    The NEAIR 2006 Conference Proceedings is a compilation of papers presented at the Philadelphia, Pennsylvania conference. Topics include: Policy Analysis, Grading Policy, State Higher Education Accountability Program, Performance Assessment, Freshmen Transfer Risk, Assessment, Degree Completion, First-Year Academic Success, Effectiveness in…

  9. WWC Quick Review of the Article "Impact of For-Profit and Nonprofit Management on Student Achievement: The Philadelphia Intervention, 2002-2008"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2010

    2010-01-01

    "Impact of For-Profit and Nonprofit Management on Student Achievement: The Philadelphia Intervention, 2002-2008" examined whether shifting from traditional district management to management by a for-profit or nonprofit organization improves student achievement. The study analyzed data on six cohorts of elementary and middle school…

  10. History and dating of the publication of the Philadelphia (1822) and London (1823) editions of Edwin James's Account of an expedition from Pittsburgh to the Rocky Mountains

    USGS Publications Warehouse

    Woodman, Neal

    2010-01-01

    The public record of Major Stephen H. Long's 1819–1820 exploration of the American north-west, Account of an expedition from Pittsburgh to the Rocky Mountains, compiled by Edwin James, contains valuable contributions regarding the natural landscapes, native peoples and wildlife of a mostly unexplored region of the American west compiled from the notes of some of America's foremost naturalists, and it includes the first descriptions of 67 new species. The original plan was to publish the Account in Philadelphia and London simultaneously, yet these two editions differ substantially in ways that are relevant to the taxonomic contributions in the work. It is generally assumed that the Philadelphia edition was published in early January 1823 and was available first, but little substantive evidence has been presented to support its priority over the London edition. Review of contemporary correspondence and periodicals indicates the Philadelphia edition was available and for sale on 31 December 1822, whereas the London edition was available in late February 1823. As previously assumed by most sources, the Philadelphia edition has priority of publication and is the authority for most species names. Its correct year of publication, however, is 1822 rather than 1823.

  11. Revision of the Philadelphia Mindfulness Scale for measuring awareness and equanimity in Goenka's Vipassana meditation with Chinese Buddhists.

    PubMed

    Zeng, Xianglong; Li, Mengdan; Zhang, Bo; Liu, Xiangping

    2015-04-01

    Goenka's 10-day Vipassana course is a widespread mindfulness course rooted in traditional Buddhism. Awareness and equanimity are two abilities cultivated in this course that are not featured in modern mindfulness-based psychotherapies and thereby not adequately measured by current mindfulness scales. The present article analyzed the Philadelphia Mindfulness Scale (PHLMS; Cardaciotto et al. in Assessment 15(2):204-223, 2008) and revised it into a short version to avoid confusion when measuring awareness and equanimity. Empirical data obtained using Chinese university students and Chinese Buddhists showed that the psychometric properties of the original version of the PHLMS had low factor loading on some items and that the short version had improved psychometric properties, especially for Buddhists. The short PHLMS also exhibited reasonable relationships with emotional outcomes and meditation practices among Buddhists. Implications for the future application of the PHLMS among Buddhists were also discussed.

  12. Using Qualified Energy Conservation Bonds for Public Building Upgrades. Reducing Energy Bills in the City of Philadelphia

    SciTech Connect

    Zimring, Mark

    2012-07-18

    Qualified Energy Conservation Bonds (QECBs) are federally-subsidized bonds that enable state, tribal, and local government issuers to borrow money to fund a range of energy conservation projects, including public building upgrades that reduce energy use by at least 20 percent, at very attractive borrowing rates and long terms. As part of the American Recovery and Reinvestment Act (ARRA), the City of Philadelphia received a $15 million QECB award from the U.S. Department of the Treasury (Treasury). The city leveraged $6.25 million of its QECB allocation to finance half of a $12.6 million initiative to upgrade the energy efficiency of City buildings. The upgrades to four city facilities are expected to deliver over $10 million of net savings, and are a major step towards achieving the city’s goal of reducing government energy consumption by 30 percent by 2015.

  13. Life and death in Philadelphia's black belt: a tale of an urban tuberculosis campaign, 1900-1930.

    PubMed

    Carthon, J Margo Brooks

    2011-01-01

    The poor health status of black Americans was a widely recognized fact during the first third of the twentieth century. Excess mortality in black communities was frequently linked to the infectious disease tuberculosis, which was particularly menacing in densely populated urban settings. As health authorities in large cities struggled to keep pace with the needs of citizens, private charities worked to launch community-oriented attacks against the deadly disease. In 1914 a novel experiment to address excess mortality among blacks was launched in Philadelphia. The success of the health promotion campaign initiated by the Henry Phipps Institute and the Whittier Centre, two private charitable associations, has been attributed primarily to the presence of black clinicians, in particular public health nurse Elizabeth Tyler. This study suggests that community health efforts also rest on partnerships between like-minded organizations and coalition building.

  14. A door-to-door survey of bed bug (Cimex lectularius) infestations in row homes in Philadelphia, Pennsylvania.

    PubMed

    Wu, Yage; Tracy, Dylan M; Barbarin, Alexis M; Barbu, Corentin M; Levy, Michael Z

    2014-07-01

    We conducted a door-to-door survey in a residential census tract of Philadelphia to estimate the prevalence and spatial patterns of recent bed bug infestations. We interviewed 596 residents, of whom 66 (11.1%) reported recent bed bug infestations. We confirmed current infestations in a subset of 15 (68.2%) of 22 inspected households. Most residents reported that their infestation began within the past year (2012-2013). We found no correlation between property value and infestation status. Spatial analyses showed significant clustering of bed bug infestations only at fine scales, suggesting limited active dispersal of the insects. Residents used a large variety of treatment methods to eliminate bed bugs, but only 48.1% reported success. Our results provide a prevalence estimate of recent bed bug infestations and highlight the importance of passive rather than active dispersal of bed bugs even among dense urban row homes.

  15. A Door-to-Door Survey of Bed Bug (Cimex lectularius) Infestations in Row Homes in Philadelphia, Pennsylvania

    PubMed Central

    Wu, Yage; Tracy, Dylan M.; Barbarin, Alexis M.; Barbu, Corentin M.; Levy, Michael Z.

    2014-01-01

    We conducted a door-to-door survey in a residential census tract of Philadelphia to estimate the prevalence and spatial patterns of recent bed bug infestations. We interviewed 596 residents, of whom 66 (11.1%) reported recent bed bug infestations. We confirmed current infestations in a subset of 15 (68.2%) of 22 inspected households. Most residents reported that their infestation began within the past year (2012–2013). We found no correlation between property value and infestation status. Spatial analyses showed significant clustering of bed bug infestations only at fine scales, suggesting limited active dispersal of the insects. Residents used a large variety of treatment methods to eliminate bed bugs, but only 48.1% reported success. Our results provide a prevalence estimate of recent bed bug infestations and highlight the importance of passive rather than active dispersal of bed bugs even among dense urban row homes. PMID:24799372

  16. Low/medium-Btu coal-gasification assessment of central plant for the city of Philadelphia, Pennsylvania

    SciTech Connect

    Not Available

    1981-02-01

    The objective of this study is to assess the technical and economic feasibility of producing, distributing, selling, and using coal gas for industrial applications in Philadelphia. From the 15 sites considered, the Philadelphia Gas Works and Riverside sites were considered excellent candidates. Early in the gasifier selection study it was decided that the level of risk associated with the gasification process should be minimal. It was therefore determined that the process should be selected from those commercially proven. The following processes were considered: Lurgi, KT, Winkler, and Wellman-Galusha. A retrofit study was carried out to assess the impact on users having to switch from oil or natural gas to low or medium Btu gas. Medium Btu gas was selected in order to service many users with gas having generally useful combustion characteristics. Between the Lurgi and KT processes (which are competitive in terms of capital costs), the KT process shows a lower operating cost and is more flexible in terms of coal feed selection. In addition, the Lurgi (and the Galusha) gasifiers produce tars, phenols, and ammonia. Effective removal of these by-produces adds to the complexity and operating inconvenience of the overall process. Therefore, the KT process (which is unique in its ability to gasify many coals) was selected. The potential range of gas costs compares favorably with No. 6 fuel oil as an energy source. Although there exists an element of risk and uncertainty which must be bounded carefully during the next phase of the study, there also exists some potential for reducing the rather conservative cost estimate which represents the high case.

  17. Community-Generated Recommendations Regarding the Urban Nutrition and Tobacco Environments: A Photo-Elicitation Study in Philadelphia

    PubMed Central

    FitzGerald, Elizabeth A.; Frasso, Rosemary; Dean, Lorraine T.; Johnson, Terry E.; Solomon, Sara; Bugos, Eva; Mallya, Giridhar

    2013-01-01

    Introduction Overweight, obesity, and tobacco use are major preventable causes of disability, disease, and death. In 2010, 25% of Philadelphia adults smoked, and 66% were overweight or obese. To address these health threats, the Philadelphia Department of Public Health launched Get Healthy Philly, an initiative to improve the city’s nutrition, physical activity, and tobacco environments. The objective of this assessment was to identify residents’ perspectives on threats to health and opportunities for change in the local food and tobacco environments. Methods Participants (N = 48) took photographs to document their concerns regarding Philadelphia’s food and tobacco environments and participated in photo-elicitation interviews. We coded photographs and interview transcripts and identified key themes. Results Participants proposed interventions for nutrition 4 times more often than for tobacco. Participants spontaneously articulated the need for multilevel change consistent with the ecological model of health behavior, including changes to policies (food assistance program provisions to encourage healthful purchases), local and school environments (more healthful corner store inventories and school meals), and individual knowledge and behavior (healthier food purchases). Participants often required interviewer prompting to discuss tobacco, and they suggested interventions including changes in advertising (a local environmental concern) and cigarette taxes (a policy concern). Conclusion Participants were well versed in the relevance to health of nutrition and physical activity and the need for multilevel interventions. Their responses suggested community readiness for change. In contrast, participants’ more limited comments regarding tobacco suggested that prevention and control of tobacco use were perceived as less salient public health concerns. PMID:23764347

  18. The Effect of Selected Cleaning Techniques on Berkshire Lee Marble: A Scientific Study at Philadelphia City Hall

    USGS Publications Warehouse

    Mossotti, Victor G.; Eldeeb, A. Raouf; Fries, Terry L.; Coombs, Mary Jane; Naude, Virginia N.; Soderberg, Lisa; Wheeler, George S.

    2002-01-01

    This report describes a scientific investigation of the effects of eight different cleaning techniques on the Berkshire Lee marble component of the facade of the East Center Pavilion at Philadelphia City Hall; the study was commissioned by the city of Philadelphia. The eight cleaning techniques evaluated in this study were power wash (proprietary gel detergent followed by water rinse under pressure), misting (treatment with potable, nebulized water for 24-36 hours), gommage (proprietary Thomann-Hanry low-pressure, air-driven, small-particle, dry abrasion), combination (gommage followed by misting), Armax (sodium bicarbonate delivered under pressure in a water wash), JOS (dolomite powder delivered in a low-pressure, rotary-vortex water wash), laser (thermal ablation), and dry ice (powdered-dry-ice abrasion delivered under pressure). In our study approximately 160 cores were removed from the building for laboratory analysis. We developed a computer program to analyze scanning-electron-micrograph images for the microscale surface roughness and other morphologic parameters of the stone surface, including the near-surface fracture density of the stone. An analysis of more than 1,100 samples cut from the cores provided a statistical basis for crafting the essential elements of a reduced-form, mixed-kinetics conceptual model that represents the deterioration of calcareous stone in terms of self-organized soiling and erosion patterns. This model, in turn, provided a basis for identifying the variables that are affected by the cleaning techniques and for evaluating the extent to which such variables influence the stability of the stone. The model recognizes three classes of variables that may influence the soiling load on the stone, including such exogenous environmental variables as airborne moisture, pollutant concentrations, and local aerodynamics, and such endogenous stone variables as surface chemistry and microstructure (fracturing, roughness, and so on). This study

  19. Dasatinib and Prednisolone Induction Therapy for a Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Dilated Cardiomyopathy Accompanied by Life-Threatening Ventricular Tachycardia

    PubMed Central

    Nakamae, Hirohisa; Matsumoto, Kana; Morita, Kunihiko; Koga, Yuki; Momose, Dai; Hino, Masayuki

    2017-01-01

    A 56-year-old man being treated for dilated cardiomyopathy presented with epigastralgia. He was diagnosed with ventricular tachycardia and Philadelphia chromosome-positive acute lymphoblastic leukemia. After treating incessant ventricular tachycardia, we commenced induction therapy for leukemia with dasatinib and prednisolone to minimize toxicity towards cardiomyocytes and the cardiac conduction system. Although dasatinib was temporarily withheld because of a recurrence of ventricular tachycardia, we rechallenged dasatinib while using bisoprolol and amiodarone and achieved a complete hematological response three weeks later. Although drug interactions between dasatinib and amiodarone were of concern, the blood concentration of each drug remained within the safe range after concomitant use, and there were no adverse cardiac effects such as QT prolongation after rechallenging dasatinib. Induction therapy with dasatinib and prednisolone may be an acceptable therapeutic option for Philadelphia chromosome-positive acute lymphoblastic leukemia with severe cardiac complications. PMID:28326207

  20. Effect of Regional-Scale Transport on Oxidants in the Vicinity of Philadelphia During the 1999 NE-OPS Field Campaign

    SciTech Connect

    Fast, Jerome D.; Zaveri, Rahul A.; Bian, Randy X.; Chapman, Elaine G.; Easter, Richard C.

    2002-08-28

    A new meteorological-chemical modeling system is used to determine the relative contribution of regional-scale transport and local photochemical production on air quality over Philadelphia. The model performance is evaluated using surface and airborne meteorological and chemical measurements made during a 30-day period in July and August of 1999 as part of the Northeast Oxidant and Particulate Study (NE-OPS). Good agreement between the simulations and observations was obtained. The bias in the vicinity of Philadelphia over the simulation period was -5.8 ppb for the peak ozone mixing ratio during the day and 2.0 ppb for the minimum ozone mixing ratio at night. Layers of ozone above the convective boundary layer were measured by both research aircraft and ozonesondes during the morning between 09 and 11 EDT. The modeling system demonstrates that upwind vertical mixing processes the previous afternoon, subsequent horizontal transport aloft, and depletion of ozone by NO titration within the stable boundary layer at night lead to the development of these layers. Ozone aloft was then entrained into the growing convective boundary, contributing to surface ozone concentrations. Through a series of sensitivity studies, we find that most of the ozone is the result of emissions in the vicinity of Philadelphia and Chesapeake Bay area, but up to 30-40% of the ozone during high-ozone episodes was due to transport from upwind sources. Local emissions and meteorological conditions were largely responsible for one high-ozone episode because of light winds.

  1. Health hazard evaluation report HETA 85-062-1652, Veterans Administration Center and Regional Office, Philadelphia, Pennsylvania

    SciTech Connect

    Bennett, D.E.; Chrostek, W.

    1986-01-01

    Concern among employees that asbestos exposure at the Veterans Administration Center and Regional Office in Philadelphia, Pennsylvania may be causing relatively high rates of cancer deaths culminated in a NIOSH evaluation of the facility. Medical and personnel records were incomplete, but death certificates were obtained for 10 of 20 presumed cancer victims. Three had died of lung cancer, two of colon cancer, and one each of gastric, small intestine, pancreas, and breast cancer. The sampling was too small to draw any conclusions concerning a cancer cluster. Bulk samples of steam pipes and damaged ceiling tiles were taken from the areas of concern. Three of the five bulk samples showed chrysotile asbestos. Ceiling tile and pipe covering contained 30-40% chrysotile asbestos. No asbestos was found in dust settled on a file cabinet. Air fiber concentrations were below the limit of detection (3000 fibers per cubic meter) in the 12 samples taken. Air samples indicated that adequate outside air is entering the working areas of the building. The authors conclude that a potential hazard from asbestos existed if pipes or ceiling tiles were damaged or disturbed.

  2. To What Extent do Sleep Quality and Duration Mediate the Effect of Perceived Discrimination on Health? Evidence from Philadelphia.

    PubMed

    Yang, Tse-Chuan; Park, Kiwoong

    2015-12-01

    Little research investigates whether sleep mediates the adverse effect of perceived discrimination on health and even less is known about whether sleep quality and sleep duration mediate the relationships in the same fashion. We applied a recently developed mediation analysis approach to a survey administered in 2008 in Philadelphia, PA, that includes 9042 adults. Health was measured with self-rated health, stress, and mental illness. Perceived discrimination was operationalized with self-reported discriminatory experience in two social contexts, namely health care system and housing market. Sleep quality and duration were measured with a five-point Likert scale and the self-reported sleep time at night, respectively. After controlling for one's demographic, socioeconomic, and health-related characteristics, the mediation analysis quantified how much sleep quality and duration can account for the effect of perceived discrimination on these health outcomes. The key findings are: (a) sleep quality and duration accounted for approximately 15 to 25% of the adverse effect of perceived discrimination. (b) Sleep quality is more important than sleep duration in mediating the relationship between perceived discrimination and health. (c) The proportion of the effect mediated by sleep differs by the social context where perceived discrimination occurred. It was confirmed that sleep mediates the relationship between perceived discrimination and health and the interventions to improve sleep, particularly sleep quality, should help to attenuate the effect of perceived discrimination on health.

  3. Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).

    PubMed

    Wassmann, Barbara; Pfeifer, Heike; Stadler, Michael; Bornhaüser, Martin; Bug, Gesine; Scheuring, Urban J; Brück, Patrick; Stelljes, Matthias; Schwerdtfeger, Rainer; Basara, Nadezda; Perz, Jolanta; Bunjes, Donald; Ledderose, Georg; Mahlberg, Rolf; Binckebanck, Anja; Gschaidmeier, Harald; Hoelzer, Dieter; Ottmann, Oliver G

    2005-07-15

    In adult Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), minimal residual disease (MRD) after stem cell transplantation (SCT) is associated with a relapse probability exceeding 90%. Starting imatinib in the setting of MRD may decrease this high relapse rate. In this prospective multicenter study, 27 Ph+ ALL patients received imatinib upon detection of MRD after SCT. Bcr-abl transcripts became undetectable in 14 (52%) of 27 patients, after a median of 1.5 months (0.9-3.7 months) ((early)CR(mol)). All patients who achieved an (early)CR(mol) remained in remission for the duration of imatinib treatment; 3 patients relapsed after imatinib was discontinued. Failure to achieve polymerase chain reaction (PCR) negativity shortly after starting imatinib predicted relapse, which occurred in 12 (92%) of 13 patients after a median of 3 months. Disease-free survival (DFS) in (early)CR(mol) patients is 91% +/- 9% and 54% +/- 21% after 12 and 24 months, respectively, compared with 8% +/- 7% after 12 months in patients remaining MRD+ (P < .001). In conclusion, approximately half of patients with Ph+ ALL receiving imatinib for MRD positivity after SCT experience prolonged DFS, which can be anticipated by the rapid achievement of a molecular complete remission (CR). Continued detection of bcr-abl transcripts after 2 to 3 months on imatinib identifies patients who will ultimately experience relapse and in whom additional or alternative antileukemic treatment should be initiated.

  4. Economic evaluation of the Annual Cycle Energy System. Volume I. Executive summary. Final report. [In Minneapolis, Atlanta, and Philadelphia

    SciTech Connect

    Not Available

    1980-05-01

    The objective of this study is to determine the energy effectiveness and the economic viability of the ACES concept. Three different classes of building are investigated, namely: single-family residence; multi-family residence; and commercial office building. The application of ACES to each of these building types is studied in three different climatic regions: Minneapolis, Atlanta, and Philadelphia. Computer programs - ACESIM for the residences and CACESS for the office building - were used, each comprised of four modules: loads; design; simulation; and economic. For each building type in each geographic location, the economic evaluation of the ACES is based on a comparison of the present worth of the ACES to the present worth of a number of conventional systems. The results of this analysis indicate that the economic viability of the ACES is very sensitive to the assumed value of the property tax, maintenace cost, and fuel-escalation rates, while it is relatively insensitive to the assumed values of other parameters. Fortunately, any conceivable change in the fuel-escalation rates would tend to increase the viability of the ACES concept. An increase in the assumed value of the maintenance cost or property tax would tend to make the ACES concept less viable; a decrease in either would tend to make the ACES concept more viable. The detailed results of this analysis are given in Section 5.4 of Volume II. 2 figures, 21 tables.

  5. Low/medium Btu coal gasification assessment of central plant for the city of Philadelphia, Pennsylvania. Final report

    SciTech Connect

    Not Available

    1981-02-01

    The objective of this study is to assess the technical and economic feasibility of producing, distributing, selling, and using fuel gas for industrial applications in Philadelphia. The primary driving force for the assessment is the fact that oil users are encountering rapidly escalating fuel costs, and are uncertain about the future availability of low sulfur fuel oil. The situation is also complicated by legislation aimed at reducing oil consumption and by difficulties in assuring a long term supply of natural gas. Early in the gasifier selection study it was decided that the level of risk associated with the gasification process sould be minimal. It was therefore determined that the process should be selected from those commercially proven. The following processes were considered: Lurgi, KT, Winkler, and Wellman-Galusha. From past experience and a knowledge of the characteristics of each gasifier, a list of advantages and disadvantages of each process was formulated. It was concluded that a medium Btu KT gas can be manufactured and distributed at a lower average price than the conservatively projected average price of No. 6 oil, provided that the plant is operated as a base load producer of gas. The methodology used is described, assumptions are detailed and recommendations are made. (LTN)

  6. Comparison of geographic methods to assess travel patterns of persons diagnosed with HIV in Philadelphia: how close is close enough?

    PubMed

    Eberhart, Michael G; Share, Amanda M; Shpaner, Mark; Brady, Kathleen A

    2015-02-01

    Travel distance to medical care has been assessed using a variety of geographic methods. Network analyses are less common, but may generate more accurate estimates of travel costs. We compared straight-line distances and driving distance, as well as average drive time and travel time on a public transit network for 1789 persons diagnosed with HIV between 2010 and 2012 to identify differences overall, and by distinct geographic areas of Philadelphia. Paired t-tests were used to assess differences across methods, and analysis of variance was used to assess between-group differences. Driving distances were significantly longer than straight-line distances (p<0.001) and transit times were significantly longer than driving times (p<0.001). Persons living in the northeast section of the city traveled greater distances, and at greater cost of time and effort, than persons in all other areas of the city (p<0.001). Persons living in the northwest section of the city traveled farther and longer than all other areas except the northeast (p<0.0001). Network analyses that include public transit will likely produce a more realistic estimate of the travel costs, and may improve models to predict medical care outcomes.

  7. The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias

    PubMed Central

    Carrà, Giovanna; Torti, Davide; Crivellaro, Sabrina; Panuzzo, Cristina; Taulli, Riccardo; Cilloni, Daniela; Guerrasio, Angelo; Saglio, Giuseppe; Morotti, Alessandro

    2016-01-01

    The Nuclear Factor-kappa B (NF-κB) family of transcription factors plays a key role in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to induce resistance to chemotherapy and to mediate invasion and metastasis. NF-κB is recruited through different mechanisms involving either canonical (RelA/p50) or non-canonical pathways (RelB/p50 or RelB/p52), which transduce the signals originated from growth-factors, cytokines, oncogenic stress and DNA damage, bacterial and viral products or other stimuli. The pharmacological inhibition of the NF-κB pathway has clearly been associated with significant clinical activity in different cancers. Almost 20 years ago, NF-κB was described as an essential modulator of BCR-ABL signaling in Chronic Myeloid Leukemia and Philadelphia-positive Acute Lymphoblastic Leukemia. This review summarizes the role of NF-κB in BCR-ABL-mediated leukemogenesis and provides new insights on the long lasting BCR-ABL/NF-κB connection. PMID:27563822

  8. Concurrent detection of heroin, fentanyl, and xylazine in seven drug-related deaths reported from the Philadelphia Medical Examiner's Office.

    PubMed

    Wong, Stella C; Curtis, John A; Wingert, William E

    2008-03-01

    Recreational drugs, such as cocaine and heroin, are often adulterated with other pharmacological agents to either enhance or diminish the drug effects. Between April 21, 2006 and August 8, 2006, the Philadelphia Medical Examiner's Office detected xylazine (a veterinary sedative) and fentanyl (a synthetic opioid) in specimens taken from seven cases. Initial immunoassay screening was performed on urine and blood for fentanyl, opiate, cocaine, phencyclidine (PCP), and benzodiazepines. All tests reported positive were confirmed by gas chromatography-mass spectrometry. All seven xylazine positive cases tested positive for fentanyl and six cases tested positive for 6-acetylmorphine (a metabolite and definitive marker for heroin). The seventh case was positive for morphine and had a history of heroin abuse. Xylazine was present in urine in all seven cases and blood levels were detected in three cases. The blood concentrations ranged from trace to 130 ng/mL. Fentanyl was present in the blood and urine in each case and blood concentrations ranged from 4.7 to 47 ng/mL. Adulteration of illicit drugs has become an epidemic health concern for drug users. Healthcare professionals need to be aware of this issue, so the patients can be treated in an effective, timely manner.

  9. Decline in cases of rotavirus gastroenteritis presenting to The Children's Hospital of Philadelphia after introduction of a pentavalent rotavirus vaccine.

    PubMed

    Clark, H Fred; Lawley, Diane; Mallette, Laura A; DiNubile, Mark J; Hodinka, Richard L

    2009-03-01

    A pentavalent rotavirus vaccine for infants became available in the United States in February 2006. By 2007, vaccination rates nationwide were estimated to be approximately 50%. We studied the effectiveness of the vaccine in a real-world setting outside of a clinical trial. All children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for the presence of rotavirus antigen in the stool by enzyme-linked immunosorbent assay (ELISA [followed by genotyping if ELISA positive]) since the 1994-1995 epidemic season, presenting a unique opportunity to assess the impact of the recently introduced vaccine. The annual number of community-acquired cases over the preceding 13 years had approached or exceeded 100, with 271 cases in 2005 to 2006 and 167 cases in 2006 to 2007. In the 2007-2008 season, only 36 community-acquired cases were identified, representing an 87% reduction from the same period in 2005 to 2006. G3 was the predominant serotype, accounting for 15 community cases (42%). Our study is limited by its observational design using historical comparisons. Nonetheless, the abrupt decline in rotavirus gastroenteritis cases during the 2007-2008 season likely resulted from vaccination. Because protection rates appeared to have exceeded vaccination rates, herd immunity may have contributed to some degree to the effectiveness of the vaccine.

  10. 76 FR 409 - Philadelphia International Airport, Capacity Enhancement Program, Environmental Impact Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ...- supported structure. The existing approach lighting systems for Runways 26 and 27C will be relocated based... (9,500 feet) and location. It will support westbound departures in west flow, and eastbound...

  11. Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two-year follow-up.

    PubMed

    Calkins, Monica E; Moore, Tyler M; Satterthwaite, Theodore D; Wolf, Daniel H; Turetsky, Bruce I; Roalf, David R; Merikangas, Kathleen R; Ruparel, Kosha; Kohler, Christian G; Gur, Ruben C; Gur, Raquel E

    2017-02-01

    Prospective evaluation of youths with early psychotic-like experiences can enrich our knowledge of clinical, biobehavioral and environmental risk and protective factors associated with the development of psychotic disorders. We aimed to investigate the predictors of persistence or worsening of psychosis spectrum features among US youth through the first large systematic study to evaluate subclinical symptoms in the community. Based on Time 1 screen of 9,498 youth (age 8-21) from the Philadelphia Neurodevelopmental Cohort, a subsample of participants was enrolled based on the presence (N=249) or absence (N=254) of baseline psychosis spectrum symptoms, prior participation in neuroimaging, and current neuroimaging eligibility. They were invited to participate in a Time 2 assessment two years on average following Time 1. Participants were administered the Structured Interview for Prodromal Syndromes, conducted blind to initial screen status, along with the Schizotypal Personality Questionnaire and other clinical measures, computerized neurocognitive testing, and neuroimaging. Clinical and demographic predictors of symptom persistence were examined using logistic regression. At Time 2, psychosis spectrum features persisted or worsened in 51.4% of youths. Symptom persistence was predicted by higher severity of subclinical psychosis, lower global functioning, and prior psychiatric medication at baseline. Youths classified as having psychosis spectrum symptoms at baseline but not at follow-up nonetheless exhibited comparatively higher symptom levels and lower functioning at both baseline and follow-up than typically developing youths. In addition, psychosis spectrum features emerged in a small number of young people who previously had not reported significant symptoms but who had exhibited early clinical warning signs. Together, our findings indicate that varying courses of psychosis spectrum symptoms are evident early in US youth, supporting the importance of

  12. Improving Fruit and Vegetable Consumption Among Low-Income Customers at Farmers Markets: Philly Food Bucks, Philadelphia, Pennsylvania, 2011

    PubMed Central

    Aquilante, Jennifer L.; Solomon, Sara; Colby, Lisa; Kawinzi, Mukethe A.; Uy, Nicky; Mallya, Giridhar

    2013-01-01

    Introduction We evaluated whether Philly Food Bucks, a bonus incentive program at farmers markets, is associated with increased fruit and vegetable consumption and Supplemental Nutrition Assistance Program (SNAP) sales at farmers markets in low-income areas. Methods A convenience sample of 662 customers at 22 farmers markets in low-income neighborhoods in Philadelphia, Pennsylvania, was surveyed via face-to-face interviews. Questions addressed shopping characteristics, self-reported change in fruit and vegetable consumption, whether customers tried new fruits or vegetables, use of Philly Food Bucks, and demographic information. Market-level SNAP sales and Philly Food Bucks redemption data were also collected to monitor sales patterns. Results Philly Food Bucks users were significantly more likely than nonusers to report increasing fruit and vegetable consumption (OR, 2.4; 95% CI, 1.6–3.7; P < .001) and to report trying new fruits or vegetables (OR 1.8; 95% CI, 1.2–2.7; P = .006). At the market level, average SNAP sales more than doubled at farmers markets in low-income areas in the first 2 years of the Philly Food Bucks program. At the city’s largest farmers market in a low-income area, the program was associated with an almost 5-fold higher increase in annual SNAP sales compared with baseline. Conclusion Results from this study demonstrate that a bonus incentive program tied to SNAP was associated with self-reported increases in fruit and vegetable consumption and increased SNAP sales at participating farmers markets in low-income communities. More research is warranted to evaluate the long-term impact of bonus incentives on farmers market use, dietary behaviors, and health outcomes. PMID:24135390

  13. Low/medium Btu coal gasification assessment of central plant for the City of Philadelphia, Pennsylvania. Executive summary

    SciTech Connect

    Not Available

    1981-02-01

    From the 15 sites considered, the Philadelphia Gas Works and Riverside sites were considered excellent candidates. Early in the study it was decided that the level of risk associated with the gasification process should be minimal. It was therefore determined that the process should be selected from those commercially proven. The following processes were considered: Lurgi, Koppers-Totzek, Winkler, and Wellman-Galusha. From past experience and knowledge of the characteristics of each gasifier, a list of advantages and disadvantages of each process was formulated. The Galusha process offered the least capital and operating costs for low Btu gas (approximately 150 Btu per cu ft), and the KT and Lurgi emerged as the better processes for medium Btu gas (approximately 300 Btu per cu ft). A study was carried out to assess the impact on users having to switch from oil or natural gas to low or medium Btu gas. Medium Btu gas was selected in order to service many users with gas having generally useful combustion characteristics. For the production of 20 billion Btu per day two gasifiers are required, each gasifying about 500 tons of coal per day. Between the Lurgi and KT processes (which are competitive in terms of capital costs), the KT process shows a lower operating cost and is more flexible in terms of coal feed selection. In addition, the Lurgi (and the Galusha) gasifiers produce tars, phenols, and ammonia. Effective removal of these by-products adds to the complexity and operating inconvenience of the overall process. Therefore, the KT process (which is unique in its ability to gasify many coals) was selected. It is probable that most users would perfer to install dual fuel burners and retain some fuel oil storage capability.

  14. Knowledge, perceptions, and behaviors related to salt use among Philadelphia Chinese take-out restaurant owners and chefs.

    PubMed

    Ma, Grace X; Shive, Steve; Zhang, Yolanda; Aquilante, Jennifer; Tan, Yin; Zhao, Mei; Solomon, Sara; Zhu, Steven; Toubbeh, Jamil; Colby, Lisa; Mallya, Giridhar; Zeng, Qiaoling

    2014-09-01

    Most of the sodium Americans consume comes from processed and restaurant foods. An upstream global strategy to promote health is to work with local restaurants to reduce sodium content in their food offerings, while accounting for food taste and economic considerations. In urban communities, Chinese take-out restaurants serve meals with large amounts of sodium and are clustered in low-income, racial/ethnic minority communities with a high prevalence of hypertension. The objective of this study is to assess baseline knowledge, attitudes, and behaviors related to sodium use/consumption among Chinese take-out owners and chefs recruited to participate in the Philadelphia Healthy Chinese Take-Out Initiative. A cross-sectional study of 221 Chinese take-out restaurants was conducted from August 2012 to February 2013. Items measured knowledge, attitudes, and behaviors related to salt use, salt consumption, and health. Most owners/chefs knew that excess sodium consumption contributes to high blood pressure but were less aware of other health effects and of major sources of sodium in the U.S. diet. The majority were willing and able to reduce sodium content in meals if customer demand could be maintained, and they desired training in food preparation, procurement, and marketing. Findings show a need to provide education, strategies, and support to Chinese take-out owners/chefs in preparing low-salt dishes. The results of this and future studies to reduce sodium content in meals by working with restaurant owners and chefs have global health promotion implications.

  15. Anti-CD19 chimeric antigen receptor T-cell therapy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia

    PubMed Central

    Zhu, Yang-min; Wu, Zhao; Tan, You-ping; Du, Yuan-yuan; Liu, Zhi; Ou, Rui-ming; Liu, Shuang; Pu, Cheng-fei; Jiang, Jing; Wang, Jin-ping; Xiao, Lei; Zhang, Qing

    2016-01-01

    Abstract Rationale: The presence of the Philadelphia chromosome (Ph) in acute lymphoblastic leukemia (ALL) has been associated with a high risk of disease relapse and a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT) is an established treatment for adults with Ph-positive ALL, but relapse remains the primary cause of treatment failure, and is associated with an extremely poor prognosis. The emergence of resistance to tyrosine kinase inhibitors (TKIs) poses a challenge for patients with disease relapses after initial treatment with TKI-containing regimens. Patient concerns: Two patients with TKI-resistant recurrent Ph-positive ALL. Diagnoses: Ph-positive ALL. Interventions: Anti-CD19 CAR T-cell infusion. Outcomes: One patient's bone marrow blasts decreased significantly, and the other reached negative minimal residual disease (MRD). However, we first recorded the development of new-onset acute graft-versus-host disease (aGVHD) after anti-CD19 CAR T-cell infusion in a patient who received allogeneic HSCT. Our 2 case reports also demonstrate the efficacy of anti-CD19 CAR T-cell therapy in the treatment of TKI-resistant Ph-positive ALL. Lessons: Our report suggests that anti-CD19 CAR T-cell therapy may be a promising option for the treatment of relapsed Ph-positive ALL after conventional chemotherapy or allogeneic HSCT. However, caution is due given the possibility of the adverse effects of cytokine release syndrome (CRS)-induced aGVHD for patients receiving allogeneic HSCT. PMID:28002337

  16. Outcome after HSCT in Philadelphia chromosome positive acute lymphoblastic leukemia in Sweden: a population-based study.

    PubMed

    Hulegårdh, E; Hägglund, H; Ahlberg, L; Karlsson, K; Karbach, H; Markuszewska, A; Persson, I; Åström, M; Hallböök, H

    2014-08-01

    Even in the tyrosine kinase inhibitor era, allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as standard care for adult Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL). In this retrospective national study, we have reviewed the outcome after HSCT in Sweden for adult Ph-positive ALL between 2000 and 2009. In total, 51 patients with median age 42 (range 20-66) years underwent HSCT. Mainly allogeneic HSCT was performed (24 related donor, 24 unrelated donor and one cord blood), and only two patients were treated with an autologous HSCT. The 5-year OS was 51 (37-64) %. The probabilities of morphological relapse and non-relapse mortality (NRM) at 5 years were 36 (23-49) and 18 (9-29) %, respectively. For the allogeneic transplanted, the 5-year OS was for patients <40 years 70 (50-90) % and for patients ≥40 years 34 (16-52) %, p = 0.002. The 5-year probability of NRM was for patients <40 years 10 (2-28) % compared to 25 (11-42) % for patients ≥40 years (p = 0.04). Patients with chronic graft-versus-host disease (GVHD) had a 5-year morphological relapse probability of 20 (6-40) % compared to 59 (35-77) % for patients without chronic GVHD (p = 0.03). Age ≥40 years and the absence of chronic GVHD were confirmed as independent negative prognostic factors for relapse and non-relapse mortality in a multivariate analysis although the impact of chronic GVHD was significant only in the older age cohort.

  17. Pediatric-inspired Therapy compared to Allografting for Philadelphia Chromosome Negative Adult ALL in First Complete Remission

    PubMed Central

    Seftel, Matthew D.; Neuberg, Donna; Zhang, Mei-Jie; Wang, Hai-Lin; Ballen, Karen Kuhn; Bergeron, Julie; Couban, Stephen; Freytes, César O.; Hamadani, Mehdi; Kharfan-Dabaja, Mohamed A.; Lazarus, Hillard M.; Nishihori, Taiga; Paulson, Kristjan; Saber, Wael; Sallan, Stephen E.; Soiffer, Robert; Tallman, Martin S.; Woolfrey, Ann E.; DeAngelo, Daniel J.; Weisdorf, Daniel J.

    2015-01-01

    For adults with Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL) in first complete remission (CR1), allogeneic hematopoietic cell transplantation (HCT) is an established curative strategy. However, pediatric-inspired chemotherapy may also offer durable leukemia free survival in the absence of HCT. We compared 422 HCT recipients aged 18-50 years with Ph-ALL in CR1 reported to the CIBMTR with an age-matched concurrent cohort of 108 Ph- ALL CR1 patients who received a Dana-Farber Consortium pediatric-inspired non-HCT regimen. At four years follow-up, incidence of relapse after HCT was 24% [95% C.I. 19-28] vs. 23% [95% C.I. 15-32] for the non-HCT (“chemo”) cohort (p=0.97). Treatment-related mortality (TRM) was higher in the HCT cohort (HCT 37% [95% C.I. 31-42] vs. chemo 6% [95% C.I. 3 – 12], p<0.0001). DFS in the HCT cohort was 40% [95% C.I. 35-45] vs. 71% [95% C.I. 60-79] for chemo, p<0.0001. Similarly, OS favored chemo (HCT 45% [95% C.I. 40-50]) vs. chemo 73% [95% C.I. 63-81], p<0.0001). In multivariable analysis, the sole factor predictive of shorter OS was the administration of HCT (HR 3.12 [1.99 – 4.90], p<0.0001). For younger adults with Ph- ALL, pediatric-inspired chemotherapy had lower TRM, no increase in relapse, and superior overall survival compared to HCT. PMID:26701142

  18. Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two‐year follow‐up

    PubMed Central

    Calkins, Monica E.; Moore, Tyler M.; Satterthwaite, Theodore D.; Wolf, Daniel H.; Turetsky, Bruce I.; Roalf, David R.; Merikangas, Kathleen R.; Ruparel, Kosha; Kohler, Christian G.; Gur, Ruben C.; Gur, Raquel E.

    2017-01-01

    Prospective evaluation of youths with early psychotic‐like experiences can enrich our knowledge of clinical, biobehavioral and environmental risk and protective factors associated with the development of psychotic disorders. We aimed to investigate the predictors of persistence or worsening of psychosis spectrum features among US youth through the first large systematic study to evaluate subclinical symptoms in the community. Based on Time 1 screen of 9,498 youth (age 8‐21) from the Philadelphia Neurodevelopmental Cohort, a subsample of participants was enrolled based on the presence (N=249) or absence (N=254) of baseline psychosis spectrum symptoms, prior participation in neuroimaging, and current neuroimaging eligibility. They were invited to participate in a Time 2 assessment two years on average following Time 1. Participants were administered the Structured Interview for Prodromal Syndromes, conducted blind to initial screen status, along with the Schizotypal Personality Questionnaire and other clinical measures, computerized neurocognitive testing, and neuroimaging. Clinical and demographic predictors of symptom persistence were examined using logistic regression. At Time 2, psychosis spectrum features persisted or worsened in 51.4% of youths. Symptom persistence was predicted by higher severity of subclinical psychosis, lower global functioning, and prior psychiatric medication at baseline. Youths classified as having psychosis spectrum symptoms at baseline but not at follow‐up nonetheless exhibited comparatively higher symptom levels and lower functioning at both baseline and follow‐up than typically developing youths. In addition, psychosis spectrum features emerged in a small number of young people who previously had not reported significant symptoms but who had exhibited early clinical warning signs. Together, our findings indicate that varying courses of psychosis spectrum symptoms are evident early in US youth, supporting the importance of

  19. An unusual outbreak of rotavirus genotype G2P[6] during the 2005-2006 epidemic season in Philadelphia.

    PubMed

    Clark, H Fred; Lawley, Diane; DiStefano, Daniel; Maliga, Marianne; Kilby, Bronwyn; Kulnis, Greg; Mallette, Laura; DiNubile, Mark J

    2011-06-01

    Most rotavirus gastroenteritis is caused by G1P[8] strains. When G2 infections are encountered, the P type has most often been reported to be P[4]. The purpose of our study was to describe an unusual outbreak of G2P[6] cases. Children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for rotavirus antigen in stool by ELISA (with G-typing if ELISA positive) since 1994-1995. Compared to the last 12 rotavirus seasons before the 2006 introduction of a new rotavirus vaccine, the 2005-2006 season had by far the highest number of evaluable rotavirus infections [n = 275 from September 2005 through June 2006, of which 261 (95%) were G typed] and the greatest number of G2 cases (n = 101, 39% of typed strains). Only 16% of G2 strains were associated with P[4], whereas genotype G2P[6] was responsible for 83% of the G2 infections. Eighty-eight percent of the 84 G2P[6] cases occurred in the 60% of patients who were African-Americans, most of whom were urban residents. Among 157 African-American patients, G2 cases (n = 80; 52%) predominated, including 74 due to G2P[6]. Children <6 months old accounted for 27% of cases overall, but 36% of the G2P[6] cases. G2 rotaviruses caused over a third of the community-acquired rotavirus cases in children presenting to CHOP in 2005-2006, attesting to the potential impact of G2 strains during some epidemics. The large majority of G2 strains had the rare P[6] genotype. Urban African-American children under 6 months of age were disproportionately affected.

  20. Historical ground-water-flow patterns and trends in iron concentrations in the Potomac--Raritan--Magothy aquifer system in parts of Philadelphia, Pennsylvania, and Camden and Gloucester Counties, New Jersey

    USGS Publications Warehouse

    Sloto, Ronald A.

    2003-01-01

    The Potomac-Raritan-Magothy (PRM) aquifer system is an important sole-source ground-water supply in Camden and Gloucester Counties, N.J. Elevated iron concentrations are a persistent water-quality problem associated with ground water from the PRM. In Philadelphia, the PRM no longer is usable as a water supply because of highly elevated concentrations of iron (as high as 429 mg/L [milligrams per liter]), manganese (as high as 4 mg/L), and sulfate (as high as 1,720 mg/L). A strongly reducing environment in the PRM in south Philadelphia causes these constituents to be remobilized by reductive dissolution of the aquifer matrix. By the 1920s, ground-water pumping changed the natural ground-water-flow patterns, and ground water flowed toward pumping centers in Philadelphia. By 1940, recharge areas changed from the topographically high areas east of Trenton, N.J., to the outcrop area of the PRM in Philadelphia, and the Delaware River became a source of recharge instead of a point of ground-water discharge. By 1954, the cone of depression caused by pumping at the former Philadelphia Naval Ship Yard (PNSY) exceeded 50 feet below NGVD 29, and the direction of ground-water flow was from New Jersey toward Philadelphia. Because of highly elevated concentrations of iron and manganese, pumping at the former PNSY ceased in the mid-1960s. Beginning about 1951, increased ground-water withdrawals from the PRM in New Jersey reversed the hydraulic gradient so that ground-water flow was from Philadelphia toward New Jersey under the Delaware River, making Philadelphia a recharge area for the PRM aquifer system in parts of Camden and Gloucester Counties. By 1988, water levels in the lower aquifer of the PRM in New Jersey had declined to 103 feet below NAVD 88. In 1943, dissolved iron concentrations ranged from 0.07 to 0.6 mg/L at the former PNSY. By 1967 when the wells at the PNSY were abandoned, dissolved iron concentrations had reached 46 mg/L. Dissolved iron concentrations in water

  1. Prevalence, Disparities, and Trends in Obesity and Severe Obesity Among Students in the School District of Philadelphia, Pennsylvania, 2006–2013

    PubMed Central

    Mallya, Giridhar; Wagner, Amanda; Buehler, James W.

    2015-01-01

    Introduction Recent analyses suggest that increases in rates of childhood obesity have plateaued nationally and may be decreasing among certain populations and communities, including Philadelphia, Pennsylvania. We examined 7 years of data, including 3 years not previously reported, to assess recent trends in major demographic groups. Methods We analyzed nurse-measured data from the School District of Philadelphia for school years 2006–07 through 2012–13 to assess trends in obesity (body mass index [BMI] ≥95th percentile) and severe obesity (BMI ≥120% of the 95th percentile) among all children aged 5 to 18 years for whom measurements were recorded. Results Over 7 school years, the prevalence of childhood obesity declined from 21.7% to 20.3% (P = .01); the prevalence of severe obesity declined from 8.5% to 7.3% (P < .001). Declines were larger among boys than among girls and among African Americans and Asians than among non-Hispanic whites and Hispanics. Over the final 3 years of study, the prevalence of obesity continued to decrease significantly among boys (including African Americans and Asians) but increased significantly among Hispanic girls and girls in grades kindergarten through 5. At the end of the study period, Hispanics had the highest prevalence of obesity among boys (25.9%) and girls (23.0%). The prevalence of severe obesity continued to trend downward in boys and decrease significantly among girls (including African American girls) but remained highest among Hispanic boys (10.1%) and African American girls (8.3%). Conclusion The prevalence of obesity and severe obesity continued to decline among children in Philadelphia, but in some groups initial reductions were reversed in the later period. Further monitoring, community engagement, and targeted interventions are needed to address childhood obesity in urban communities. PMID:26292065

  2. Barriers to Receiving Follow-Up Eye Care and Detection of Non-Glaucomatous Ocular Pathology in the Philadelphia Glaucoma Detection and Treatment Project.

    PubMed

    Zheng, Cindy X; Hu, Wanda D; Tran, Judie; Siam, Linda; Berardi, Giuliana G; Sembhi, Harjeet; Hark, Lisa A; Katz, L Jay; Waisbourd, Michael

    2016-04-01

    This cross-sectional study aimed to evaluate adherence rates and identify barriers to receiving follow-up eye care in participants diagnosed with significant non-glaucomatous eye pathology in the Philadelphia Glaucoma Detection and Treatment Project. This community-based project aimed to improve detection, management, treatment, and follow-up eye care of individuals at high risk for glaucoma in community-based settings. Participants throughout Philadelphia, Pennsylvania, USA were enrolled. After a comprehensive eye examination, follow-up recommendations were given to each participant. A telephone survey was administered to individuals diagnosed with non-glaucomatous ocular pathology 3 months after initial eye examination to assess rates of follow-up and to evaluate potential barriers to follow-up. Of the 1649 participants enrolled in this project, 249 (15 %) were diagnosed with significant non-glaucomatous ocular pathology requiring follow-up care. There were 143 (57 %) who responded to the telephone survey. Respondents had a median age of 72 years, and were predominately female (69 %) and African-American (64 %). Of the respondents, 36 (25 %) attended a follow-up appointment. Participants who did not remember the results of their examinations, did not remember their recommendations, and had not seen an eye doctor within the past year were less likely to make a follow-up appointment (P = 0.04, 0.001 and 0.005, respectively). The Philadelphia Glaucoma Detection and Treatment Program was able to detect a significant amount of non-glaucomatous ocular pathology requiring follow-up care. Actual follow-up rates were sub-optimal. Further research is needed to determine interventions to overcome barriers and increase adherence with follow-up recommendations.

  3. 3q26.2/EVI1 rearrangement is associated with poor prognosis in classical Philadelphia chromosome-negative myeloproliferative neoplasms.

    PubMed

    Hu, Zhihong; Medeiros, L Jeffrey; Wang, Wei; Chen, Zi; Tang, Guilin; Hodjat, Parsa; Yang, Su; Fang, Lianghua; Li, Yan; Verstovsek, Srdan; Hu, Shimin

    2017-03-24

    Classical Philadelphia chromosome-negative myeloproliferative neoplasms are a group of closely related myeloid disorders with different histologic features and clinical presentations at an early stage, but all later develop into a similar fibrotic stage with variable risk of acute transformation. The significance of 3q26.2/EVI1 rearrangement has been well recognized in acute myeloid leukemia, myelodysplastic syndrome, and chronic myeloid leukemia. However, the clinical importance of 3q26.2/EVI1 rearrangement in classical Philadelphia chromosome-negative myeloproliferative neoplasms is unknown. Here we reported 15 patients with classical Philadelphia chromosome-negative myeloproliferative neoplasms showing 3q26.2 rearrangement, including inv(3)(q21q26.2) (n=6), t(3;21)(q26.2;q22)(n=4), t(3;3)(q21;q26.2)(n=3), inv(3)(q13.3q26.2)(n=1), and t(3;12)(q26.2;p13)(n=1). In addition to 3q26.2 rearrangement, 9 of 15 cases had other concurrent karyotypical abnormalities, including -7/7q- and -5/5q-. There were 8 men and 7 women with a median age of 59 years (range, 35-79 years) at initial diagnosis of myeloproliferative neoplasms: 8 patients had primary myelofibrosis, 4 had polycythemia vera, and 3 had essential thrombocythemia. JAK2 V617F mutation was detected in 8/14 patients, including 4/4 with polycythemia vera. The median interval from the initial diagnosis of myeloproliferative neoplasms to the detection of 3q26.2 rearrangement was 44 months (range, 1-219 months). At time of emergence of 3q26.2 rearrangement, 11 patients were in blast phase and 2 patients had increased blasts (6-19%). Dyspoiesis, predominantly in megakaryocytes, were detected in all patients with adequate specimens at time of 3q26.2 rearrangement. Following 3q26.2 rearrangement, 12 patients received chemotherapy, but none of them achieved complete remission. Of 14 patients with follow-up information, all died with a median overall survival time of only 3 months (range 0-14 months) after the emergence of

  4. The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia chromosome-negative myeloproliferative neoplasms

    PubMed Central

    2014-01-01

    Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs). We performed high resolution melting analysis and Sanger sequencing together with T-A cloning to elucidate the unique mutation profile of these genes, in Chinese patients with MPNs. Peripheral blood DNA samples were obtained from 80 patients with polycythemia vera (PV), 80 patients with essential thrombocytosis (ET) and 50 patients with primary myelofibrosis (PMF). Ten PV patients were identified with diverse JAK2 exon 12 mutations. Five novel JAK2 Exon 12 mutation patterns (M532V/E543G, N533D, M535I/H538Y/K549I, E543G and D544N) were described. JAK2 V617F was detected in 140 samples (66 PV, 45 ET and 29 PMF). JAK2 Exon 12 mutations were prevalent (13%) and variable in the Chinese patients. Compared with PV patients with JAK2 V617F mutations, PV patients with JAK2 exon 12 mutations had an earlier median onset of disease (P = 0.0013). MPL W515L/K mutations were discerned in 4 ET and 3 PMF patients. Two kinds of CALR mutation, c. 1179_1230del and c. 1234_1235insTTGTC were detected in 20 ET and 16 PMF patients. A novel CALR mutation pattern (c. 1173_1223del/c. 1179_1230del) was identified in 2 PMF samples. In addition, 17 scattered point mutations in CALR c.1153 to c.1255 were also detected in 13 cases with CALR frame-shifting variations and 2 cases without CALR frame-shifting variations. Female patients showed a predisposition to CALR mutations (P = 0.0035). Chinese Ph-negative MPN patients have a unique mutation landscape in the common molecular markers of MPN diagnosis. Validation of the molecular diagnostic pipeline should be emphasized since there is a considerable ethnical diversity in the molecular profiles of Ph-negative MPNs. PMID:25023898

  5. The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia chromosome-negative myeloproliferative neoplasms.

    PubMed

    Wu, Zhiyuan; Zhang, Xinju; Xu, Xiao; Chen, Yuming; Hu, Tingting; Kang, Zhihua; Li, Shibao; Wang, Hua; Liu, Weiwei; Ma, Xiaochao; Guan, Ming

    2014-07-15

    Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs). We performed high resolution melting analysis and Sanger sequencing together with T-A cloning to elucidate the unique mutation profile of these genes, in Chinese patients with MPNs. Peripheral blood DNA samples were obtained from 80 patients with polycythemia vera (PV), 80 patients with essential thrombocytosis (ET) and 50 patients with primary myelofibrosis (PMF). Ten PV patients were identified with diverse JAK2 exon 12 mutations. Five novel JAK2 Exon 12 mutation patterns (M532V/E543G, N533D, M535I/H538Y/K549I, E543G and D544N) were described. JAK2 V617F was detected in 140 samples (66 PV, 45 ET and 29 PMF). JAK2 Exon 12 mutations were prevalent (13%) and variable in the Chinese patients. Compared with PV patients with JAK2 V617F mutations, PV patients with JAK2 exon 12 mutations had an earlier median onset of disease (P = 0.0013). MPL W515L/K mutations were discerned in 4 ET and 3 PMF patients. Two kinds of CALR mutation, c. 1179_1230del and c. 1234_1235insTTGTC were detected in 20 ET and 16 PMF patients. A novel CALR mutation pattern (c. 1173_1223del/c. 1179_1230del) was identified in 2 PMF samples. In addition, 17 scattered point mutations in CALR c.1153 to c.1255 were also detected in 13 cases with CALR frame-shifting variations and 2 cases without CALR frame-shifting variations. Female patients showed a predisposition to CALR mutations (P = 0.0035). Chinese Ph-negative MPN patients have a unique mutation landscape in the common molecular markers of MPN diagnosis. Validation of the molecular diagnostic pipeline should be emphasized since there is a considerable ethnical diversity in the molecular profiles of Ph-negative MPNs.

  6. A Community Like "Philadelphia."

    ERIC Educational Resources Information Center

    Brookey, Robert Alan

    1996-01-01

    Argues that applications of "queer theory" must extend beyond questions of sexual representation. Contends that rhetorical theory can contribute to the investigation of sexuality, offering as an example an analysis of mainstream media representations of the homosexual "community." Concludes that the presentation of this…

  7. 'The Best Health Care Delivery System in the World'? Women's health and maternity/newborn care trends in Philadelphia, PA, United States-1997-2011: a case report.

    PubMed

    McCool, William F; Guidera, Mamie; Janis, Jaclyn

    2013-10-01

    Despite being ranked number one globally in terms of health care cost per capita, the United States (US) has ranked as low as 37th in the world in terms of health care system performance. This poor performance for one of the most developed nations in the world has been reflected in the underachieved attempts of the multiple US health care systems at improving maternal and newborn health, according to the goals set in 2000 by the United Nations with Millennium Development Goals (MDG's) 5: Improve Maternal Health, and 4: Reduce Child Mortality. This paper will examine the progress, or lack thereof, over a period of 15 years of the fifth largest urban area in the US - Philadelphia, Pennsylvania - in its delivery of health care to pregnant women and their newborns. Using data collected from national, state, and city health agencies, trends concerning pregnancy care will be presented and compared to the target goals of MDG-5 and MDG-4, as well as Healthy People 2020, a US government-based initiative to improve health care of all Americans. Findings will demonstrate that urban areas such as Philadelphia are on a path of not reaching goals that have been set by the United Nations and the US government, and by some indicators are moving away in a negative direction from these goals.

  8. Simulation of ground-water flow in the lower sand unit of the Potomac-Raritan-Magothy aquifer system, Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Sloto, R.A.

    1988-01-01

    Ground-water flow in the lower sand unit of the Potomac-Raritan-Magothy aquifer system in Philadelphia was simulated with a two-dimensional finite- difference ground-water model. The modeled 133-square-mile area also included parts of Delaware County, Pennsylvania, and Camden and Gloucester Counties, New Jersey. The lower sand unit is Cretaceous in age and consists of well- sorted coarse sand and fine gravel that grades upward into medium to fine sand containing a few thin beds of clay. The modeled aquifer consists of the lower sand unit in Philadelphia and the lowermost sand unit of the Potomac-Raritan-Magothy aquifer system in New Jersey. Throughout most of the area, the lower sand unit is overlain by a clay confining unit. Where the clay is absent, the lower sand unit is unconfined. A hydraulic conductivity of 1.6 x 10-3 foot per second and a storage coefficient of 3.0 x 10-4 was assigned to the lower sand unit based on 15 aquifer tests, and a hydraulic conductivity of 4.0 x 10-8 foot per second was assigned to the upper confining unit based on transient-flow sensitivity analysis. Water levels were not sensitive to changes in the value for specific storage of the upper confining unit, indicating that most vertical leakage occurs as steady leakage. Changes in the potentiometric surface of the lower sand unit for 1904-78 simulated. Differences between simulated and observed head generally were less than 10 feet. Simulations were made to determine the effects on hydraulic head of increases in industrial pumpage of 5 and 10 Mgal/d (million gallons per day) and of an emergency 60 Mgal/d municipal water supply in Philadelphia. A 5- and 10-Mgal/d increase in industrial pumpage would lower heads in the lower sand unit by as much as 33 and 66 feet, respectively. Pumping 60 Mgal/d for 30 days for an emergency municipal supply would lower heads in the lower sand unit by as much as 121 feet.

  9. The Comparative Effects of Two Teaching Methodologies on the Social Structure, Learning Environment, and Group-Work Behavior of Eight Senior High School English Classes: An Evaluative Study of the Philadelphia Affective Education Development Program.

    ERIC Educational Resources Information Center

    Cohen, Milton

    This study evaluated the Philadelphia Affective Education Development Program (AEDP) as it affected student relationships within the classroom and student perceptions of the classroom climate. The differences between four AEDP and four regular English classes from one high school were determined in regard to (1) sociometric structure as analyzed…

  10. The Crisis in Home Health Care: Greater Need, Less Care. Hearing before the Special Committee on Aging. United States Senate, Ninety-Ninth Congress, Second Session (Philadelphia, PA, July 28, 1986).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Special Committee on Aging.

    This document presents witnesses' testimonies and prepared statements from the Congressional hearing held in Philadelphia, Pennsylvania to examine reports of inappropriate, at times illegal, denials of critical home health care to sick older Americans. In his opening statement, Senator John Heinz presents examples of victims who were denied proper…

  11. Section 2: Case Studies of the Politics of Privatization: Bringing the Private into the Public--Changing the Rules of the Game and New Regime Politics in Philadelphia Public Education

    ERIC Educational Resources Information Center

    Bulkley, Katrina E.

    2007-01-01

    Substantial policy and political changes have resulted from a 2001 state takeover of the Philadelphia School District and the subsequent hiring of Paul Vallas as the district's new CEO. Using the lens of urban regime analysis, which emphasizes the importance of public and private actors in forming a governing coalition, this article analyzes the…

  12. Cytogenetics in the management of Philadelphia-negative myeloproliferative neoplasms: an update by the Groupe francophone de cytogénétique hématologique (GFCH).

    PubMed

    Bilhou-Nabéra, Chrystèle; Bidet, Audrey; Eclache, Virginie; Lippert, Eric; Mozziconacci, Marie-Joëlle

    2016-10-01

    The recent years have witnessed tremendous progress in the molecular characterization of Philadelphia-negative myeloproliferative neoplasms (MPN). Beside a better understanding of pathophysiology, these abnormalities often constitute very useful diagnostic markers in diseases where exclusion of reactive states used to be the strongest argument. However, conventional and molecular cytogenetics keep a major interest in MPN, either as a second line exploration, in cases where no molecular marker is available, for differential diagnosis or as a proof of clonality or in first line for cases with hyperleukocytosis, for differential diagnosis (CML), to evidence druggable targets (ABL1, RET, PDGFR…) or as a prognosis marker. In this article, we will review the interest of cytogenetic techniques in myeloproliferative neoplasms.

  13. Patan hospital experience in treating philadelphia chromosome/BCR-ABL1 positive chronic myeloid leukemia patients with gleevec (imatinib mesylate); the first generation specific tyrosine kinase inhibitor

    PubMed Central

    2010-01-01

    Background Chronic Myeloid Leukemia (CML) is caused by the abnormal fusion protein BCR-ABL1, a constitutively active tyrosine kinase and product of the Philadelphia chromosome. Gleevec (Imatinib mesylate) is a selective inhibitor of this kinase. Treatment with this agent is known to result in hematologic, cytogenetic, and molecular responses. Patan hospital (Patan, Nepal) is one of the Gleevec International Patient Assistance Program (GIPAP) centers for patients with CML. Methods A total of 106 Philadelphia positive CML patients were enrolled in our center between Feb 2003 and Jun 2008, and 103 of them were eligible for cytogenetic and/or hematologic response analyses. Results Out of 103 patients, 27% patients underwent cytogenetic analysis. Imatinib induced major cytogenetic responses in 89% and complete hematologic responses in almost 100% of the patients with confirmed CML. After a mean follow up of 27 months, an estimated 90% of the patients on imatinib remained in hematologic remission and more than 90% of the patients are still alive. About 30% of patients developed some form of manageable myelosuppression. A few patients developed non-hematologic toxic side effects such as edema and hepatotoxicity. Conclusions Our study demonstrates that imatinib is safe to use in a developing country. Furthermore, we demonstrate that imatinib is very effective and induced long lasting responses in a high proportion of patients with Ph chromosome/BCR-ABL1 positive CML. Imatinib is well tolerated by our patients. The lack of cytogenetic analysis in the majority of our patients hindered our ability to detect inadequate responses to imatinib and adjust therapy appropriately. PMID:21138592

  14. Development, validity, and normative data study for the 12-word Philadelphia Verbal Learning Test [czP(r)VLT-12] among older and very old Czech adults.

    PubMed

    Bezdicek, Ondrej; Libon, David J; Stepankova, Hana; Panenkova, Erika; Lukavsky, Jiri; Garrett, Kelly Davis; Lamar, Melissa; Price, Catherine C; Kopecek, Miloslav

    2014-01-01

    The aim of the present study was to assess the validity of a 12-word Czech version of the Philadelphia (repeatable) Verbal Learning Test [czP(r)VLT-12]. The construction of the czP(r)VLT-12 was modeled after the California Verbal Learning Test (CVLT) and the nine-word Philadelphia (repeatable) Verbal Learning Test [P(r)VLT]. The czP(r)VLT-12 was constructed from a large corpus of old (60-74) and very old (75-96) Czech adults (n = 540). Participants met strict inclusion criteria for the absence of any active or past neurodegenerative disorders and performed within normal limits on other neuropsychological measures. Principal component analysis (PCA) and correlations between czP(r)VLT-12 factor structure and other memory tests were conducted. The czP(r)VLT-12 produced a four-factor solution, accounting for 70.90% of variance, with factors related to: (1) recall, (2) extra-list intrusion errors/recognition foils, (3) interference, and (4) acquisition rate; a solution similar to the CVLT and P(r)VLT. Increasing age resulted in a decline in most czP(r)VLT-12 indices, women outperformed men, and higher education led to higher scores. Memory performance in normal aging did not correlate with instrumental activities of daily living. Low, but significant, correlations were seen with other tests of cognitive performance (divergent validity). Appendices are available that provide normed percentile estimates of individual czP(r)VLT-12 performance stratified by age, education, and gender. In accordance with previous studies, these results demonstrate the usefulness of czP(r)VLT-12 in assessing declarative memory in older adults.

  15. The health status and well-being of low-resource, housing-unstable, single-parent families living in violent neighbourhoods in Philadelphia, Pennsylvania

    PubMed Central

    Jacoby, Sara F.; Tach, Laura; Guerra, Terry; Wiebe, Douglas J.; Richmond, Therese S.

    2016-01-01

    The health and well-being of single-parent families living in violent neighbourhoods in US cities who participate in housing programmes is not well described. This two-phase, mixed-methods study explores the health status of families who were participants in a housing-plus programme in Philadelphia, Pennsylvania between 2011 and 2013 and the relationship between the characteristics of the neighbourhoods in which they lived and their perceptions of well-being and safety. In phase 1, data collected with standardised health status instruments were analysed using descriptive statistics and independent sample t-tests to describe the health of single parents and one randomly selected child from each parent’s household in comparison to population norms. In a subset of survey respondents, focus groups were conducted to generate an in-depth understanding of the daily lives and stressors of these families. Focus group data were analysed using content analysis to identify key descriptive themes. In phase 2, daily activity path mapping, surveys and interviews of parent–child dyads were collected to assess how these families perceive their health, neighbourhood and the influence of neighbourhood characteristics on the families’ day-to-day experience. Narratives and activity maps were combined with crime data from the Philadelphia Police Department to analyse the relationship between crime and perceptions of fear and safety. Phase 1 data demonstrated that parent participants met or exceeded the national average for self-reported physical health but fell below the national average across all mental health domains. Over 40% reported moderate to severe symptoms of depression. Parents described high levels of stress resulting from competing priorities, financial instability, and concern for their children’s well-being and safety. Analysis of phase 2 data demonstrated that neighbourhood characteristics exert influence over parents’ perceptions of their environment and how

  16. The health status and well-being of low-resource, housing-unstable, single-parent families living in violent neighbourhoods in Philadelphia, Pennsylvania.

    PubMed

    Jacoby, Sara F; Tach, Laura; Guerra, Terry; Wiebe, Douglas J; Richmond, Therese S

    2017-03-01

    The health and well-being of single-parent families living in violent neighbourhoods in US cities who participate in housing programmes is not well described. This two-phase, mixed-methods study explores the health status of families who were participants in a housing-plus programme in Philadelphia, Pennsylvania between 2011 and 2013 and the relationship between the characteristics of the neighbourhoods in which they lived and their perceptions of well-being and safety. In phase 1, data collected with standardised health status instruments were analysed using descriptive statistics and independent sample t-tests to describe the health of single parents and one randomly selected child from each parent's household in comparison to population norms. In a subset of survey respondents, focus groups were conducted to generate an in-depth understanding of the daily lives and stressors of these families. Focus group data were analysed using content analysis to identify key descriptive themes. In phase 2, daily activity path mapping, surveys and interviews of parent-child dyads were collected to assess how these families perceive their health, neighbourhood and the influence of neighbourhood characteristics on the families' day-to-day experience. Narratives and activity maps were combined with crime data from the Philadelphia Police Department to analyse the relationship between crime and perceptions of fear and safety. Phase 1 data demonstrated that parent participants met or exceeded the national average for self-reported physical health but fell below the national average across all mental health domains. Over 40% reported moderate to severe symptoms of depression. Parents described high levels of stress resulting from competing priorities, financial instability, and concern for their children's well-being and safety. Analysis of phase 2 data demonstrated that neighbourhood characteristics exert influence over parents' perceptions of their environment and how they permit

  17. Assessment of contamination and misclassification biases in a randomized controlled trial of a social network peer education intervention to reduce HIV risk behaviors among drug users and risk partners in Philadelphia, PA and Chiang Mai, Thailand

    PubMed Central

    Simmons, Nicole; Donnell, Deborah; Ou, San-san; Celentano, David D.; Aramrattana, Apinun; Davis-Vogel, Annet; Metzger, David; Latkin, Carl

    2015-01-01

    Context Controlled trials of educational interventions are susceptible to contamination. Objectives To test a contamination measure based on recall of terms. Main study A randomized controlled trial of a social network peer education intervention among 1,123 injection drug users and risk partners in Philadelphia, PA and Chiang Mai, Thailand. Methods We assessed the recall of test, negative and positive control terms by intervention and control arm participants and compared the relative odds (OR) of recall of test vs. negative control terms between study arms. Results The contamination measure showed good discriminant ability only among participants from Chiang Mai. In Philadelphia there was no evidence of contamination and little evidence of diffusion. In Chiang Mai there was evidence of diffusion and contamination of 4 of 5 terms tested. Conclusions Network structure and peer education in Chiang Mai likely led to contamination. Recall of intervention materials can be a useful method to detect contamination in trials of educational interventions. PMID:25935214

  18. Assessment of contamination and misclassification biases in a randomized controlled trial of a social network peer education intervention to reduce HIV risk behaviors among drug users and risk partners in Philadelphia, PA and Chiang Mai, Thailand.

    PubMed

    Simmons, Nicole; Donnell, Deborah; Ou, San-San; Celentano, David D; Aramrattana, Apinun; Davis-Vogel, Annet; Metzger, David; Latkin, Carl

    2015-10-01

    Controlled trials of HIV prevention and care interventions are susceptible to contamination. In a randomized controlled trial of a social network peer education intervention among people who inject drugs and their risk partners in Philadelphia, PA and Chiang Mai, Thailand, we tested a contamination measure based on recall of intervention terms. We assessed the recall of test, negative and positive control terms among intervention and control arm participants and compared the relative odds of recall of test versus negative control terms between study arms. The contamination measures showed good discriminant ability among participants in Chiang Mai. In Philadelphia there was no evidence of contamination and little evidence of diffusion. In Chiang Mai there was strong evidence of diffusion and contamination. Network structure and peer education in Chiang Mai likely led to contamination. Recall of intervention materials can be a useful method to detect contamination in experimental interventions.

  19. Use of monoclonal antibodies in an epidemiological marker system: a retrospective study of lung specimens from the 1976 outbreak of Legionnaires disease in Philadelphia by indirect fluorescent-antibody and enzyme-linked immunosorbent assay methods.

    PubMed Central

    Brown, S L; Bibb, W F; McKinney, R M

    1985-01-01

    Autopsy specimens of lung tissues from 15 patients that contracted legionellosis during the 1976 Philadelphia outbreak of Legionnaires disease were examined for the presence of Legionella organisms and soluble antigens by indirect fluorescent-antibody (IFA) testing and by an enzyme-linked immunosorbent assay (ELISA) with both polyclonal and monoclonal antibodies. In all 15 cases, at least one specimen was positive for Legionella pneumophila serogroup 1 (Lp-1) antigens by a polyclonal antibody ELISA system. Of the 15 cases tested for Lp-1, 9 were positive by a polyclonal antibody IFA test. Nine mouse monoclonal antibodies to Lp-1 gave essentially the same reactivity pattern with extracts from lung tissue homogenates as that obtained with a Philadelphia 1 culture extract by using a monoclonal antibody ELISA system. The same monoclonal antibody panel gave similar results when used in the IFA system with tissue homogenates. Monoclonal antibodies can be used as epidemiological marker systems with both IFA and ELISA testing. This study provides evidence that the 1976 common source outbreak in Philadelphia was probably caused by a single Lp-1 strain. ELISA testing of the soluble antigen of Lp-1 from lung tissue homogenate supernatants was more sensitive than IFA testing of the homogenates and should be extremely useful as either a primary test or as an adjunct to fluorescent antibody testing for legionellosis. Images PMID:3881470

  20. Exploring the role of gender norms in nutrition and sexual health promotion in a piloted school-based intervention: The Philadelphia Ujima™ experience.

    PubMed

    Núñez, Ana; Robertson-James, Candace; Reels, Serita; Jeter, Janay; Rivera, Hilda; Yusuf, Zena; Liu

    2015-08-01

    Perceptions of masculinity and femininity influence behaviors and can be identified in young children and adolescents (Brannon, 2004). Thus, adolescents' engagement in health risk or promoting behaviors is influenced by perceptions of masculinity and femininity and the differences in expectations, norms and responsibilities for girls and boys (WHO, 2007). Girls and boys have different needs, and gender-based interventions that consider similarities as well as differences are needed. A gender-based nutrition and sexual health promotion program was developed and piloted by the Philadelphia Ujima Coalition in a high school setting. To explore the gender differences in adolescents' perceptions of the influence of gender norms on weight, nutrition, physical activity, and sexual health and the implication of these differences in future gender-integrated health promotion programming for youth, a content analysis of student and facilitator debriefing forms were implemented for the participating schools. The content analysis was used to identify central themes, concepts gained, and overall impact of the intervention sessions. Overall, gender norms influence healthy eating practices and activity through influencing perceptions of body type in adolescents. Gender norms also influence sexual activity and decision making through influencing perceptions of beauty, masculinity, femininity, pressures and popular concepts related to sexual activity. Thus, interventions that address gender may more effectively promote health and wellness in adolescents.

  1. Acculturation and Post-Migration Stress in Middle-Aged Chinese Immigrant Women in Philadelphia: Variation between the Fujianese and the non-Fujianese women

    PubMed Central

    Ying, Yu-Wen; Han, Meekyung; Tseng, Marilyn

    2012-01-01

    The experience of acculturation in Chinese immigrant women from the rural coastal province of Fujian has not been well studied despite of their growing numbers in American cities. This exploratory study is an attempt to examine the experience of acculturation and post-migration stress in Fujianese immigrant women as compared to those from other parts of China. The study is based on a convenience sample 240 Fujianese and 162 non-Fujianese Chinese immigrant women living in Philadelphia. Results from bivariate analyses showed that the variation in demographic characteristics between Fujianese and non-Fujianese women was marginal; that all Chinese women in this study reported experiencing a unidimensional process of acculturation and a domain-generic model of acculturation; and that the Fujianese women showed a higher level of post-migration stress than the non-Fujianese women. In multiple regression controlling for demographic characteristics and including all the women in our sample, more acculturated women reported a higher level of post-migration stress. However, separate multiple regression analyses for Fujianese and non-Fujianese women revealed a different pattern of post-migration stress models. The findings suggest the importance of further research to understand acculturation and post-migration stress among Fujianese immigrant women. PMID:22451743

  2. JAK2 V617F detected in two B-cell chronic lymphocytic leukemia patients without coexisting Philadelphia chromosome-negative myeloproliferative neoplasms: A report of two cases

    PubMed Central

    YANG, YI-NING; QIN, YOU-WEN; WANG, CHUN

    2014-01-01

    The JAK2 V617F mutation has been observed in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs), including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. This mutation has also been observed in a small number of other myeloid malignancies, such as acute myeloid leukemia, chronic myeloid leukemia and myelodysplastic syndrome. The JAK2 V617F allele has rarely been evaluated in lymphoproliferative disorders. In total, 28 JAK2 V617F-positive B-cell lymphocytic leukemia (B-CLL) patients have previously been reported and all presented with Ph-MPN concomitantly. However, following investigation of the JAK2 V617F mutation in 63 B-CLL patients at the Shanghai First People’s Hospital (Shanghai, China) between January 2008 and December 2012 via allele-specific polymerase chain reaction, two B-CLL patients without a history of Ph-MPN were identified to carry the JAK2 V617F allele. PMID:25013507

  3. Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy.

    PubMed

    Ravandi, Farhad; Jorgensen, Jeffrey L; Thomas, Deborah A; O'Brien, Susan; Garris, Rebecca; Faderl, Stefan; Huang, Xuelin; Wen, Sijin; Burger, Jan A; Ferrajoli, Alessandra; Kebriaei, Partow; Champlin, Richard E; Estrov, Zeev; Challagundla, Pramoda; Wang, Sa A; Luthra, Rajyalakshmi; Cortes, Jorge E; Kantarjian, Hagop M

    2013-08-15

    From 2001 to 2011, 122 patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia were treated with chemotherapy + imatinib (n = 54) or + dasatinib (n = 68). One hundred fifteen (94%) achieved complete remission (CR) including 101 patients who achieved it with only 1 induction course and had at least 1 minimal residual disease (MRD) assessment; 25 patients underwent an allogeneic stem cell transplant in first CR and were excluded, leaving 76 patients as the subject of this report. MRD monitoring by multiparameter flow cytometry (MFC) and real-time quantitative polymerase chain reaction (PCR) was performed at the end of induction and at ~3-month intervals thereafter. Median age was 54 years (range, 21-84 years). There was no difference in survival by achievement of at least a major molecular response (MMR; BCR-ABL/ABL < 0.1%) at CR (P = .22). Patients achieving MMR at 3, 6, 9, and 12 months had a better survival (P = .02, .04, .05, and .01, respectively). Negative MFC at CR did not predict for improved survival (P = .2). At 3 and 12 months, negative MRD by MFC was associated with improved survival (P = .04 and .001). MRD monitoring by PCR and MFC identifies patients who benefit from treatment intensification in first CR.

  4. Detection of MRD may predict the outcome of patients with Philadelphia chromosome–positive ALL treated with tyrosine kinase inhibitors plus chemotherapy

    PubMed Central

    Jorgensen, Jeffrey L.; Thomas, Deborah A.; O’Brien, Susan; Garris, Rebecca; Faderl, Stefan; Huang, Xuelin; Wen, Sijin; Burger, Jan A.; Ferrajoli, Alessandra; Kebriaei, Partow; Champlin, Richard E.; Estrov, Zeev; Challagundla, Pramoda; Wang, Sa A.; Luthra, Rajyalakshmi; Cortes, Jorge E.; Kantarjian, Hagop M.

    2013-01-01

    From 2001 to 2011, 122 patients with newly diagnosed Philadelphia chromosome–positive acute lymphoblastic leukemia were treated with chemotherapy + imatinib (n = 54) or + dasatinib (n = 68). One hundred fifteen (94%) achieved complete remission (CR) including 101 patients who achieved it with only 1 induction course and had at least 1 minimal residual disease (MRD) assessment; 25 patients underwent an allogeneic stem cell transplant in first CR and were excluded, leaving 76 patients as the subject of this report. MRD monitoring by multiparameter flow cytometry (MFC) and real-time quantitative polymerase chain reaction (PCR) was performed at the end of induction and at ∼3-month intervals thereafter. Median age was 54 years (range, 21-84 years). There was no difference in survival by achievement of at least a major molecular response (MMR; BCR-ABL/ABL < 0.1%) at CR (P = .22). Patients achieving MMR at 3, 6, 9, and 12 months had a better survival (P = .02, .04, .05, and .01, respectively). Negative MFC at CR did not predict for improved survival (P = .2). At 3 and 12 months, negative MRD by MFC was associated with improved survival (P = .04 and .001). MRD monitoring by PCR and MFC identifies patients who benefit from treatment intensification in first CR. PMID:23836561

  5. Proceedings of the 34th International Conference in High Energy Physics (ICHEP08), Philadelphia, PA, 2008, eConf C080730, [hep-ph/0809.xxx

    SciTech Connect

    Lockyer, Nigel S.; Smith, AJ Stewart,; et. al.

    2008-09-01

    In 2004 a team from the University of Pennsylvania, Princeton University, and the Institute for Advanced Study proposed to host the 2008 International Conference on High Energy Physics (ICHEP) on the campus of the University of Pennsylvania in Philadelphia. The proposal was approved later that year by the C-11 committee of the International Union of Pure and Applied Physics. The Co-Chairs were Nigel S. Lockyer (U. Penn/TRIUMF) and A.J. Stewart Smith (Princeton); Joe Kroll of U. Penn served as Deputy Chair from 2007 on. Highlights of the proposal included 1. greatly increased participation of young scientists, women scientists, and graduate students 2. new emphasis on formal theory 3. increased focus on astrophysics and cosmology 4. large informal poster session (170 posters) in prime time 5. convenient, contiguous venues for all sessions and lodging 6. landmark locations for the reception and banquet. The conference program consisted of three days of parallel sessions and three days of plenary talks.

  6. Does weather confound or modify the association of particulate air pollution with mortality? An analysis of the Philadelphia data, 1973--1980

    SciTech Connect

    Samet, J.; Zeger, S.; Kelsall, J.; Xu, J.; Kalkstein, L.

    1998-04-01

    This report considers the consequences of using alternative approaches to controlling for weather and explores modification of air pollution effects by weather, as weather patterns could plausibly alter air pollution`s effect on health. The authors analyzed 1973--1980 total mortality data for Philadelphia using four weather models and compared estimates of the effects of TSP and SO{sub 2} on mortality using a Poisson regression model. Two synoptic categories developed by Kalkstein were selected--The Temporal Synoptic Index (TSI) and the Spatial Synoptic Classification (SSC)--and compared with (1) descriptive models developed by Schwartz and Dockery (S-D); and (2) LOESS, a nonparametric function of the previous day`s temperature and dew point. The authors considered model fit using Akaike`s Information Criterion (AIC) and changes in the estimated effects of TSP and SO{sub 2}. In the full-year analysis, S-D is better than LOESS at predicting mortality, and S-D and LOESS are better than TSI, as measured by AIC. When TSP or SO{sub 2} was fit alone, the results were qualitatively similar, regardless of how weather was controlled; when TSP and SO{sub 2} were fit simultaneously, the S-D and LOESS models give qualitatively different results than TSI, which attributes more of the pollution effect to SO{sub 2} than to TSP. Model fit is substantially poorer with TSI.

  7. Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia.

    PubMed

    Boulos, Nidal; Mulder, Heather L; Calabrese, Christopher R; Morrison, Jeffrey B; Rehg, Jerold E; Relling, Mary V; Sherr, Charles J; Williams, Richard T

    2011-03-31

    The introduction of cultured p185(BCR-ABL)-expressing (p185+) Arf (-/-) pre-B cells into healthy syngeneic mice induces aggressive acute lymphoblastic leukemia (ALL) that genetically and phenotypically mimics the human disease. We adapted this high-throughput Philadelphia chromosome-positive (Ph(+)) ALL animal model for in vivo luminescent imaging to investigate disease progression, targeted therapeutic response, and ALL relapse in living mice. Mice bearing high leukemic burdens (simulating human Ph(+) ALL at diagnosis) entered remission on maximally intensive, twice-daily dasatinib therapy, but invariably relapsed with disseminated and/or central nervous system disease. Although relapse was frequently accompanied by the eventual appearance of leukemic clones harboring BCR-ABL kinase domain (KD) mutations that confer drug resistance, their clonal emergence required prolonged dasatinib exposure. KD P-loop mutations predominated in mice receiving less intensive therapy, whereas high-dose treatment selected for T315I "gatekeeper" mutations resistant to all 3 Food and Drug Administration-approved BCR-ABL kinase inhibitors. The addition of dexamethasone and/or L-asparaginase to reduced-intensity dasatinib therapy improved long-term survival of the majority of mice that received all 3 drugs. Although non-tumor-cell-autonomous mechanisms can prevent full eradication of dasatinib-refractory ALL in this clinically relevant model, the emergence of resistance to BCR-ABL kinase inhibitors can be effectively circumvented by the addition of "conventional" chemotherapeutic agents with alternate antileukemic mechanisms of action.

  8. Acculturation and Post-Migration Stress in Middle-Aged Chinese Immigrant Women in Philadelphia: Variation between the Fujianese and the non-Fujianese women.

    PubMed

    Ying, Yu-Wen; Han, Meekyung; Tseng, Marilyn

    2012-01-01

    The experience of acculturation in Chinese immigrant women from the rural coastal province of Fujian has not been well studied despite of their growing numbers in American cities. This exploratory study is an attempt to examine the experience of acculturation and post-migration stress in Fujianese immigrant women as compared to those from other parts of China. The study is based on a convenience sample 240 Fujianese and 162 non-Fujianese Chinese immigrant women living in Philadelphia.Results from bivariate analyses showed that the variation in demographic characteristics between Fujianese and non-Fujianese women was marginal; that all Chinese women in this study reported experiencing a unidimensional process of acculturation and a domain-generic model of acculturation; and that the Fujianese women showed a higher level of post-migration stress than the non-Fujianese women. In multiple regression controlling for demographic characteristics and including all the women in our sample, more acculturated women reported a higher level of post-migration stress. However, separate multiple regression analyses for Fujianese and non-Fujianese women revealed a different pattern of post-migration stress models. The findings suggest the importance of further research to understand acculturation and post-migration stress among Fujianese immigrant women.

  9. CD38+ CD58- is an independent adverse prognostic factor in paediatric Philadelphia chromosome negative B cell acute lymphoblastic leukaemia patients.

    PubMed

    Li, Xu-Mian; Zhang, Le-Ping; Wang, Ya-Zhe; Lu, Ai-Dong; Chang, Yan; Zhu, Hong-Hu; Qin, Ya-Zhen; Lai, Yue-Yun; Kong, Yuan; Huang, Xiao-Jun; Liu, Yan-Rong

    2016-04-01

    To explore new risk predictors for a high risk of relapse in Philadelphia chromosome negative (Ph-) B cell acute lymphoblastic leukaemia (B-ALL) patients, 196 paediatric Ph- B-ALL patients (≤ 18 years) were retrospectively analysed. We mainly focus on investigating the prognostic value of CD38 and CD58 expression in leukemic blasts in these patients by four colour flow cytometry. The CD38+ CD58- group (n=16) had a higher relapse rate, a shorter 3-year event-free survival (EFS) and overall survival (OS) than the CD38+ CD58+ group (n=157; 31.3% vs 10.2%, P=0.04; 52.4% vs 92.3%, P<0.01; 32.5% vs 91.0%, P=0.01); CD38+ CD58- was an independent adverse prognostic predictor for relapse (hazard ratio [HR], 0.203; 95%CI, 0.063-0.656; P=0.01), 3-year EFS (HR, 0.091; 95%CI, 0.023-0.355; P<0.01) and OS (HR, 0.102; 95%CI, 0.026-0.3971; P<0.01) in this cohort, as determined by Cox multivariate analysis. We identified, for the first time, a higher risk population of paediatric Ph- B-ALL patients with CD38+ CD58- who had a higher relapse risk and a shorter survival. Our results may allow better risk stratification and individualized treatment.

  10. Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia

    SciTech Connect

    Hooberman, A.L.; Carrino, J.J.; Leibowitz, D.; Rowley, J.D.; Le Beau, M.M.; Arlin, Z.A.; Westbrook, C.A. )

    1989-06-01

    The Philadelphia (Ph{sup 1}) chromosome results in a fusion of portions of the BCR gene from chromosome 22 and the ABL gene from chromosome 9, producing a chimeric BCR-ABL mRNA and protein. In lymphoblastic leukemias, there are two molecular subtypes of the Ph{sup 1} chromosome, one with a rearrangement of the breakpoint cluster region (bcr) of the BCR gene, producing the same 8.5-kilobase BCR-ABL fusion mRNA seen in chronic myelogenous leukemia (CML), and the other, without a bcr rearrangement, producing a 7.0-kilobase BCR-ABL fusion mRNA that is seen only in acute lymphoblastic leukemia (ALL). The authors studied the molecular subtype of the Ph{sup 1} chromosome in 11 cases of Ph{sup 1}-positive ALL, including 2 with a previous diagnosis of CML, using a sensitive method to analyze the mRNA species based on the polymerase chain reaction (PCR). They observed unexpected heterogeneity in BCR-ABL mRNA in this population. They conclude that the PCR gives additional information about the Ph{sup 1} chromosome gene products that cannot be obtained by genomic analysis, but that it cannot be used as the sole means of detection of this chromosomal abnormality in ALL because of the high incidence of false negative results.

  11. Determination of time-of-travel, dispersion characteristics, and oxygen reaeration coefficients during low streamflows--Lower Tacony/Frankford Creek, Philadelphia, Pennsylvania

    USGS Publications Warehouse

    Senior, Lisa A.; Gyves, Matthew C.

    2010-01-01

    Time-of-travel, dispersion characteristics, and oxygen reaeration coefficients were determined by use of dye and gas tracing for a 2-mile reach of Tacony/Frankford Creek in Philadelphia, southeastern Pennsylvania. The reach frequently has concentrations of dissolved oxygen (DO) below the water-quality standard of 4 milligrams per liter during warm months. Several large combined sewer overflows (CSOs), including one of the largest in Philadelphia (former Wingohocking Creek), discharge to the study reach in this urbanized watershed, affecting water quality and the timing and magnitude of storm peaks. In addition, a dam that commonly results in backwater conditions and reduced natural reaeration is present a few hundred feet from the end of the study reach. Time-of-travel and reaeration data were collected under base-flow conditions in August and September 2009 for three sub-reaches from Roosevelt Boulevard (U.S. Route 1) to Castor Avenue. Determination of traveltimes to the centroid of the dye cloud were needed for calculation of the reaeration coefficients. Results of the dye study in Tacony/Frankford Creek indicate that traveltimes were affected by the presence of man-made structures, such as the large scour hole and pool developed at the outfall of the T14 CSO and the dam, both of which reduce stream velocities. Mean stream velocities during the dye-tracer tests ranged from a maximum of 0.44 to 0.04 foot per second through a large pool. The dispersion efficiency of the stream was determined from relations between normalized unit concentrations to time to peak for use in water-quality modeling. Oxygen reaeration coefficients determined by a constant rate-injection method using propane as the tracer gas were as low as 0.04 unit per hour in a long pool affected by backwater conditions behind a dam. The highest reaeration coefficient was 2.29 units per hour for a steep-gradient reach with multiple winding channels through gravel deposits, just downstream of a large

  12. Dimethyl sulfoxide (DMSO) waste residues and municipal waste water odor by dimethyl sulfide (DMS): the north-east WPCP plant of Philadelphia.

    PubMed

    Glindemann, Dietmar; Novak, John; Witherspoon, Jay

    2006-01-01

    This study shows for the first time that overlooked mg/L concentrations of industrial dimethyl sulfoxide (DMSO) waste residues in sewage can cause "rotten cabbage" odor problems bydimethyl sulfide (DMS) in conventional municipal wastewater treatment. In laboratory studies, incubation of activated sludge with 1-10 mg/L DMSO in bottles produced dimethyl sulfide (DMS) at concentrations that exceeded the odor threshold by approximately 4 orders of magnitude in the headspace gas. Aeration at a rate of 6 m3 air/m3 sludge resulted in emission of the DMS into the exhaust air in a manner analogous to that of an activated sludge aeration tank. A field study atthe NEWPCP sewage treatment plant in Philadelphia found DMSO levels intermittently peaking as high as 2400 mg/L in sewage near an industrial discharger. After 3 h, the DMSO concentration in the influent to the aeration tank rose from a baseline level of less than 0.01 mg/L to a level of 5.6 mg/L and the DMS concentration in the mixed liquor rose from less than 0.01 to 0.2 mg/L. Finding this link between the intermittent occurrence of DMSO residues in influent of the treatment plant and the odorant DMS in the aeration tank was the keyto understanding and eliminating the intermittent "canned corn" or "rotten cabbage" odor emissions from the aeration tank that had randomly plagued this plant and its city neighborhood for two decades. Sewage authorities should consider having wastewater samples analyzed for DMSO and DMS to check for this possible odor problem and to determine whether DMSO emission thresholds should be established to limit odor generation at sewage treatment plants.

  13. Prognostic significance of ASXL1, JAK2V617F mutations and JAK2V617F allele burden in Philadelphia-negative myeloproliferative neoplasms

    PubMed Central

    Yonal-Hindilerden, Ipek; Daglar-Aday, Aynur; Akadam-Teker, Basak; Yilmaz, Ceylan; Nalcaci, Meliha; Yavuz, Akif Selim; Sargin, Deniz

    2015-01-01

    Background Despite insights into the genetic basis of Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPNs), a significant proportion of essential thrombocythemia (ET) and primary myelofibrosis (PMF) patients present with no known MPN disease alleles. There were no previous studies investigating the impact of ASXL1 mutations in Ph-negative MPNs in Turkey. In the current study, we investigated the prognostic significance of ASXL1 mutations in Turkish MPN patients. We also aimed to determine the prognostic significance of JAK2V617F allele burden and the relationship of JAK2V617F mutation with ASXL1 mutations in Ph-negative MPNs. Methods About 184 patients from a single center diagnosed with Ph-negative MPNs were screened for ASXL1, JAK2V617F mutations, and JAK2V617F allele burden: 107 ET and 77 PMF. Results A total of 29 ASXL1 mutations were detected in 24.7% of PMF and 8.4% of ET patients. ASXL1-mutated ET patients showed a trend toward an increase in the incidence of cerebrovascular events and higher total leukocyte counts. ASXL1-mutation in PMF was associated with older age and a higher prevalence of bleeding complications. In univariate analysis, overall survival (OS) was significantly reduced in ASXL1-mutated PMF patients. In multivariate analysis, Dynamic International Prognostic Scoring System-plus high-risk category and ASXL1 mutation status were independently associated with shorter survival in PMF. In PMF, mutational status and allele burden of JAK2V617F showed no difference in terms of OS and leukemia-free survival. Conclusion We conclude that ASXL1 mutations are molecular predictors of short OS in PMF. PMID:26082670

  14. Determination of prognosis of Philadelphia chromosome-negative myeloproliferative neoplasms with a simple clinical examination: Retrospective analysis of 71 patients in a single institution

    PubMed Central

    ITO, SHINICHI; TSUTSUMI, YUTAKA; OHIGASHI, HIROYUKI; SHIRATORI, SOUICHI; TESHIMA, TAKANORI

    2016-01-01

    Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocytosis (ET) and primary myelofibrosis (PMF), are clonal hematopoietic diseases. A single-institution retrospective analysis was performed, including 71 MPN patients diagnosed at the Hakodate Municipal Hospital between April, 2001 and April, 2014, and certain clinical characteristics were identified as effective prognostic factors. The patients were categorized by risk factor scoring based on age, number of abnormal blood cell lineages and splenomegaly at diagnosis, and the association between this categorization and prognosis was analyzed using a statistical procedure. The effect of Janus kinase 2 (JAK2) V617F mutation on prognosis was also investigated. The MPN patients were consolidated into three risk groups based on the margin of intergroup survival differences: i) Score 1–2 (n=23), ii) score 3 (n=24) and iii) score 4–5 (n=24). MPN patients with scores of 4 or 5 exhibited poorer overall survival (OS) compared with those with lower scores (P<0.001). In addition, there were significant differences in event-free survival (EFS) among scoring groups (P=0.0059). PV and ET had a better prognosis compared with PMF, although this analysis suggested that PV and ET patients with scores of 4 or 5 may have a poorer prognosis in terms of OS (P=0.0052) and EFS (P=0.022) and should be closely followed up. We observed no significant prognostic effect of the JAK2V167F mutation for OS (P=0.28) or EFS (P=0.17). Our results suggested that a simple scoring system based on age, blood cell counts and presence of splenomegaly at diagnosis may be used for the long-term prognosis of MPN patients. PMID:26870357

  15. Long-Term Follow-up of Phase II Study of Chemotherapy Plus Dasatinib for the Initial Treatment of Patients with Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia

    PubMed Central

    Ravandi, Farhad; O'Brien, Susan; Cortes, Jorge; Thomas, Deborah; Garris, Rebecca; Faderl, Stefan; Burger, Jan; Rytting, Michael; Ferrajoli, Alessandra; Wierda, William; Verstovsek, Srdan; Champlin, Richard; Kebriaei, Partow; McCue, Deborah; Huang, Xuelin; Jabbour, Elias; Garcia-Manero, Guillermo; Estrov, Zeev; Kantarjian, Hagop

    2015-01-01

    Background The long-term efficacy of combination of chemotherapy with dasatinib in patients with Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) is not well-established. Methods Patients received dasatinib with 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate. Patients in complete remission (CR) continued maintenance dasatinib, vincristine and prednisone for 2 years followed by dasatinib indefinitely. Patients eligible for allogeneic stem cell transplant (SCT) received it in first CR. Results 72 patients with a median age of 55 years (range 21 – 80) were treated; 69 (96%) achieved CR. Among them, 57 (83%) achieved cytogenetic (CG) CR after 1 cycle and 64 (93%) achieved a major molecular response (MMR) at a median of 4 weeks (range, 2 – 38 weeks). Minimal residual disease by flow cytometry was negative in 65 (94 %) patients at a median of 3 weeks (range, 2–37). Dasatinib-related grade 3 and 4 adverse events included bleeding, pleural/pericardial effusions, and elevated transaminases. With a median follow-up of 67 months (range, 33–97), 33 patients (46%) are alive and 30 (43%) are in CR; 12 underwent an allogeneic SCT. Thirty nine patients have died (3 at induction, 19 after relapse, 7 post SCT performed in CR1, and 10 in CR). The median disease free and overall survival are 31 months (range, 0.3 to 97) and 47 months (range, 0.2 to 97). Seven relapsed patients had ABL mutations including 4 T315I. Conclusion Combination of chemotherapy with dasatinib is effective in achieving long-term remissions in patients with newly diagnosed Ph+ ALL. PMID:26308885

  16. Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth

    PubMed Central

    1994-01-01

    The p210bcr/abl tyrosine kinase appears to be responsible for initiating and maintaining the leukemic phenotype in chronic myelogenous leukemia (CML) patients. p21ras-p120GAP interactions play a central role in transducing mitogenic signals. Therefore, we investigated whether p21ras and p120GAP are regulated by p210bcr/abl, and whether this activation is functionally significant for CML cell proliferation. We report that transient expression of p210bcr/abl in fibroblast-like cells induces simultaneous activation of p21ras and inhibition of GTPase-promoting activity of p120GAP, and confirm these data showing that downregulation of p210bcr/abl expression in CML cells with bcr/abl antisense oligodeoxynucleotides induces both inhibition of p21ras activation and stimulation of GTPase-promoting activity of p120GAP. Tyrosine phosphorylation of two p120GAP-associated proteins, p190 and p62, which may affect p120GAP activity, also depends on p210bcr/abl tyrosine kinase expression. Direct dependence of these effects on the kinase activity is proven in experiments in which expression of c-MYB protein in fibroblast-like cells or downregulation of c-MYB expression resulting in analogous inhibition of CML cell proliferation does not result in the same changes. Use of specific antisense oligodeoxynucleotides to downregulate p21ras expression revealed a requirement for functional p21ras in the proliferation of Philadelphia chromosome-positive CML primary cells. Thus, the p210bcr/abl-dependent regulation of p120GAP activity is responsible, in part, for the maintenance of p21ras in the active GTP-bound form, a crucial requirement for CML cell proliferation. PMID:8195713

  17. Immunological effects of nilotinib prophylaxis after allogeneic stem cell transplantation in patients with advanced chronic myeloid leukemia or philadelphia chromosome-positive acute lymphoblastic leukemia

    PubMed Central

    Shouval, Roni; Eldror, Shiran; Lev, Atar; Davidson, Jacqueline; Rosenthal, Esther; Volchek, Yulia; Shem-Tov, Noga; Yerushalmi, Ronit; Shimoni, Avichai; Somech, Raz; Nagler, Arnon

    2017-01-01

    Allogeneic stem cell transplantation remains the standard treatment for resistant advanced chronic myeloid leukemia and Philadelphia chromosome–positive acute lymphoblastic leukemia. Relapse is the major cause of treatment failure in both diseases. Post-allo-SCT administration of TKIs could potentially reduce relapse rates, but concerns regarding their effect on immune reconstitution have been raised. We aimed to assess immune functions of 12 advanced CML and Ph+ ALL patients who received post-allo-SCT nilotinib. Lymphocyte subpopulations and their functional activities including T-cell response to mitogens, NK cytotoxic activity and thymic function, determined by quantification of the T cell receptor (TCR) excision circles (TREC) and TCR repertoire, were evaluated at several time points, including pre-nilotib-post-allo-SCT, and up to 365 days on nilotinib treatment. NK cells were the first to recover post allo-SCT. Concomitant to nilotinib administration, total lymphocyte counts and subpopulations gradually increased. CD8 T cells were rapidly reconstituted and continued to increase until day 180 post SCT, while CD4 T cells counts were low until 180−270 days post nilotinib treatment. T-cell response to mitogenic stimulation was not inhibited by nilotinib administration. Thymic activity, measured by TREC copies and surface membrane expression of 24 different TCR Vβ families, was evident in all patients at the end of follow-up after allo-SCT and nilotinib treatment. Finally, nilotinib did not inhibit NK cytotoxic activity. In conclusion, administration of nilotinib post allo-SCT, in attempt to reduce relapse rates or progression of Ph+ ALL and CML, did not jeopardize immune reconstitution or function following transplantation. PMID:27880933

  18. Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial

    PubMed Central

    Ribera, Josep-Maria; Oriol, Albert; González, Marcos; Vidriales, Belén; Brunet, Salut; Esteve, Jordi; del Potro, Eloy; Rivas, Concepción; Moreno, Maria-José; Tormo, Mar; Martín-Reina, Victoria; Sarrá, Josep; Parody, Ricardo; de Oteyza, Jaime Pérez; Bureo, Encarna; Bernal, Maria-Teresa

    2010-01-01

    Background Imatinib, given concurrently or alternating with chemotherapy, has improved the response and survival of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) but relapses are still frequent. The aim of this study was to evaluate the feasibility and results of giving imatinib concurrently with intensive chemotherapy, stem cell transplantation and post-transplant imatinib maintenance therapy in patients with newly diagnosed Ph+ ALL. Design and Methods This was a phase II study of patients with newly diagnosed Ph+ ALL given standard chemotherapy, together with imatinib (400 mg/day) until stem cell transplantation, followed by imatinib maintenance therapy for all patients regardless of the molecular status of the disease. Results Of the 30 patients included, 27 (90%) achieved complete remission, one was resistant to treatment and two died during induction therapy. The percentages of major and complete molecular responses were 86% and 21% after induction, and 81% and 65% after consolidation, respectively. Similar results were observed assessing minimal residual disease by flow cytometry. Of the 27 patients who achieved complete remission, 21 underwent stem cell transplantation (16 allogeneic, 5 autologous). Imatinib (400 mg/day) could be administered after transplantation for a median of 3.9 months in 12 patients, although it was interrupted in 10 patients (in 2 cases because of side effects of the drug). Nine patients relapsed, four before and five after stem cell transplantation and eight patients died of transplant-related causes. With a median follow-up of 4.1 years, the probabilities (95% CI) of disease-free and overall survival were 30% (15% to 45%) and 30% (16% to 45%), respectively. Conclusions These results confirm that imatinib is an effective first-line treatment for adult Ph+ ALL when given concurrently with chemotherapy, making stem cell transplantation feasible in a high proportion of patients. However, post

  19. Creation of a retrospective job-exposure matrix using surrogate measures of exposure for a cohort of US career firefighters from San Francisco, Chicago and Philadelphia

    PubMed Central

    Dahm, Matthew M; Bertke, Stephen; Allee, Steve; Daniels, Robert D

    2015-01-01

    Objectives To construct a cohort-specific job-exposure matrix (JEM) using surrogate metrics of exposure for a cancer study on career firefighters from the Chicago, Philadelphia and San Francisco Fire Departments. Methods Departmental work history records, along with data on historical annual fire-runs and hours, were collected from 1950 to 2009 and coded into separate databases. These data were used to create a JEM based on standardised job titles and fire apparatus assignments using several surrogate exposure metrics to estimate firefighters’ exposure to the combustion byproducts of fire. The metrics included duration of exposure (cumulative time with a standardised exposed job title and assignment), fire-runs (cumulative events of potential fire exposure) and time at fire (cumulative hours of potential fire exposure). Results The JEM consisted of 2298 unique job titles alongside 16 174 fire apparatus assignments from the three departments, which were collapsed into 15 standardised job titles and 15 standardised job assignments. Correlations were found between fire-runs and time at fires (Pearson coefficient=0.92), duration of exposure and time at fires (Pearson coefficient=0.85), and duration of exposure and fire-runs (Pearson coefficient=0.82). Total misclassification rates were found to be between 16–30% when using duration of employment as an exposure surrogate, which has been traditionally used in most epidemiological studies, compared with using the duration of exposure surrogate metric. Conclusions The constructed JEM successfully differentiated firefighters based on gradient levels of potential exposure to the combustion byproducts of fire using multiple surrogate exposure metrics. PMID:26163543

  20. Cytogenetic and Molecular Analyses of Philadelphia Chromosome Variants in CML (chronic myeloid leukemia) Patients from Sindh using Karyotyping and RT-PCR

    PubMed Central

    Ujjan, Ikram Din; Akhund, Anwar Ali; Saboor, Muhammad; Qureshi, Muhammad Asif; Khan, Saeed

    2015-01-01

    Objective: To determine the frequency of Philadelphia chromosome (Ph) and its variants in chronic myeloid leukemia (CML) cases at a tertiary care hospital of Sindh. Methods: The study was conducted at the Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro and Isra University Hospital, Hyderabad during May-to-September 2014. Bone marrow and peripheral blood samples from a total of 145 diagnosed cases of CML were collected. Cytogenetic analyses were performed using karyotyping as per the International System for Human Cytogenetic Nomenclature guidelines. All karyotypic images were analyzed using the Cytovision software. In order to identify BCR-ABL transcripts, RT-PCR was performed. Statistical analysis of the data was done using SPSS-version-21.0. Results: Of the 145 samples, a total of 133 (91.7%) were positive for the Ph (Ph+) while 12 (8.3%) were negative for the Ph (Ph-). Of the 133 Ph+ samples, standard karyotypes were noted in 121 (91%), simple variants in 9 (6.7%) and complex variants in 3 (2.3%) of the samples. All the Ph+ samples (n=133) showed BCR-ABL positivity. Of the 12 Ph- samples, a total of 7 (58.3%) were BCR-ABL-positive and 5 (41.6%) were BCR-ABL-negative. Conclusion: Frequency of the Ph was found to be of 90.9% in CML patients using a highly sensitive technique, the RT-PCR. Cytogenetic abnormalities were at a lower frequency. Cytogenetic and molecular studies must be conducted for better management of CML cases. These findings could be very useful in guiding the appropriate therapeutic options for CML patients. PMID:26430433

  1. Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of philadelphia chromosome-positive acute lymphoblastic leukemia.

    PubMed

    Chen, Huan; Liu, Kai-yan; Xu, Lan-ping; Chen, Yu-hong; Han, Wei; Zhang, Xiao-hui; Wang, Yu; Qin, Ya-zhen; Liu, Yan-rong; Huang, Xiao-jun

    2015-06-01

    The role of haploidentical related allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) is not clear. We aimed to investigate the long-term survival of Ph(+) ALL patients who underwent haploidentical donor (HID)-HSCT and to analyze the factors influencing relapse and survival after allo-HSCT. The study population included Ph(+) ALL patients who underwent haploidentical related allo-HSCT. Additionally, Ph(+) ALL patients who underwent HLA-matched related donor (MRD) transplants during the same period were included to compare outcomes. BCR-ABL transcript levels were analyzed by using real-time quantitative reverse transcription PCR. Clinical data from 139 Ph(+) ALL patients who received allo-HSCT in our center were analyzed. Of these patients, 101 received HID transplants and 38 received MRD transplants. At a median follow-up of 36 months, 5-year disease-free survival (DFS) and overall survival (OS) rates in the HID transplant group were 65.8% and 74.0%, respectively. The 5-year cumulative incidence of relapse (CIR) and nonrelapse mortality (NRM) rates for the HID transplant group were 20.3% and 15.6%, respectively. In addition, there were no differences in OS, DFS, CIR, and NRM between the HID and MRD groups. Multivariate analysis showed that imatinib resistance was a significant factor influencing DFS and CIR in HID transplant patients. Haploidentical HSCT for the treatment of Ph(+) ALL achieves promising long-term survival, which is comparable with that of HLA-MRD HSCT. Imatinib resistance is a negative predictor of relapse and DFS after allo-HSCT.

  2. Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH).

    PubMed

    Appelmann, Iris; Kreher, Stephan; Parmentier, Stefani; Wolf, Hans-Heinrich; Bisping, Guido; Kirschner, Martin; Bergmann, Frauke; Schilling, Kristina; Brümmendorf, Tim H; Petrides, Petro E; Tiede, Andreas; Matzdorff, Axel; Griesshammer, Martin; Riess, Hanno; Koschmieder, Steffen

    2016-04-01

    Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression to myelofibrosis and acute leukemia. Major bleeding represents a common and important complication in MPN, and the incidence of such bleeding events will become even more relevant in the future due to the increasing disease prevalence and survival of MPN patients. This review discusses the causes, differential diagnoses, prevention, and management of bleeding episodes in patients with MPN, aiming at defining updated standards of care in these often challenging situations.

  3. Adults with Philadelphia chromosome–like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

    PubMed Central

    Herold, Tobias; Schneider, Stephanie; Metzeler, Klaus H.; Neumann, Martin; Hartmann, Luise; Roberts, Kathryn G.; Konstandin, Nikola P.; Greif, Philipp A.; Bräundl, Kathrin; Ksienzyk, Bianka; Huk, Natalia; Schneider, Irene; Zellmeier, Evelyn; Jurinovic, Vindi; Mansmann, Ulrich; Hiddemann, Wolfgang; Mullighan, Charles G.; Bohlander, Stefan K.; Spiekermann, Karsten; Hoelzer, Dieter; Brüggemann, Monika; Baldus, Claudia D.; Dreyling, Martin; Gökbuget, Nicola

    2017-01-01

    Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic and clinical characterization of Ph-like ALL in adults. Twenty-six (13%) of 207 adult patients (median age: 42 years) with B-cell precursor ALL (BCP-ALL) were classified as having Ph-like ALL using gene expression profiling. The frequency of Ph-like ALL was 27% among 95 BCP-ALL patients negative for BCR-ABL1 and KMT2A-rearrangements. IGH-CRLF2 rearrangements (6/16; P=0.002) and mutations in JAK2 (7/16; P<0.001) were found exclusively in the Ph-like ALL subgroup. Clinical and outcome analyses were restricted to patients treated in German Multicenter Study Group for Adult ALL (GMALL) trials 06/99 and 07/03 (n=107). The complete remission rate was 100% among both Ph-like ALL patients (n=19) and the “remaining BCP-ALL” cases (n=40), i.e. patients negative for BCR-ABL1 and KMT2A-rearrangements and the Ph-like subtype. Significantly fewer Ph-like ALL patients reached molecular complete remission (33% versus 79%; P=0.02) and had a lower probability of continuous complete remission (26% versus 60%; P=0.03) and overall survival (22% versus 64%; P=0.006) at 5 years compared to the remaining BCP-ALL patients. The profile of genetic lesions in adults with Ph-like ALL, including older adults, resembles that of pediatric Ph-like ALL and differs from the profile in the remaining BCP-ALL. Our study is the first to demonstrate that Ph-like ALL is associated with inferior outcomes in intensively treated older adult patients. Ph-like adult ALL should be recognized as a distinct, high-risk entity and further research on improved diagnostic and therapeutic approaches is needed. (NCT00199056, NCT00198991) PMID:27561722

  4. Dendritic cells generated from blood precursors of chronic myelogenous leukemia patients carry the Philadelphia translocation and can induce a CML-specific primary cytotoxic T-cell response.

    PubMed

    Eibl, B; Ebner, S; Duba, C; Böck, G; Romani, N; Erdel, M; Gächter, A; Niederwieser, D; Schuler, G

    1997-11-01

    Dendritic cells (DC) are professional antigen-presenting cells specialized in the initiation of primary immune responses. We were interested to know whether mature DC can be grown in vitro from peripheral blood mononuclear cells (PBMC) of patients with chronic myelogenous leukemia (CML), and whether they carry the Philadelphia (Ph) translocation. Using a method recently described, DC were generated from PBMC precursors of 12 patients with CML using GM-CSF, IL-4, and monocyte-conditioned medium. DC exhibited the typical morphology with thin cytoplasmatic processes and expressed high levels of MHC class II, CD86, and CD83 typical for mature DC. After sorting with the monoclonal antibody CD83, a cell population of more than 95% CD83 positive cells was obtained. The presence of the Ph translocation was analyzed in these cells, in PBMC, lymphoblastoid cell lines (LCL), and in phytohemagglutinin (PHA)-induced T blasts from the same patients by fluorescence in situ hybridization (FISH). In contrast to all other cells analyzed, the vast majority of DC (95.9 +/- 0.7%) displayed the Ph translocation, irrespective of disease stage or therapy. PBMC were predominantly positive for the Ph chromosome (67.6 +/- 7.3%), whereas only 11.4 +/- 1% of the B cells and 4.4 +/- 1.1% of the PHA blasts carried the Ph translocation. Using such leukemic DC as antigen-presenting cells, a primary CML-directed cytotoxic immune response in vitro was obtained, as shown by the specific recognition of Ph chromosome positive cells. We conclude that DC can be generated from blood progenitors of CML patients in vitro and exhibit, to a large extent, the Ph translocation. Such DC, which in a preliminary experiment have been able to induce a primary CML-directed cytotoxic immune response in vitro, might be ideal candidates for adoptive immunotherapy either by direct transfer of DC for in vivo generation of a T-cell response or by in vitro generation of CML-specific cytotoxic autologous or HLA

  5. A study of the attitudes and academic achievement in biology of females in a single-sex school vs. a coeducational school in the Philadelphia Archdiocesan secondary schools

    NASA Astrophysics Data System (ADS)

    Proach, John Ann

    2000-11-01

    There is proof that the educational system has conveyed unrealistic role expectations and has neglected to address the changing needs of girls. Children form attitudes about themselves and others based on the communications they get over time from parents, other adults, peers, and a variety of societal influences, including school. This study focused on two groups of tenth-grade high school, female, biology students in the Archdiocese of Philadelphia. The purpose was to compare attitude in science and academic achievement of females in a single-sex vs. a coeducational school. Data collection included three attitudinal surveys: Women in Science, Science Attitude Scale, and Perceptions of Science and Scientists, also the National Association of Biology Teachers/National Science Teachers High School Biology Examination Version B. administered as a pretest and posttest to measure academic achievement. These instruments were used to determine if the differences between attitudes and perceptions toward science and achievement in science were alike for females in a single-sex school and a coeducational school. The study also tested to see if females in a single-sex school would attain greater academic achievement in biology than girls in a coeducational school. The Chi-square statistic was used to analyze data in the three attitudinal surveys. The NABT/NSTA High School Biology Examination determined the students' initial and final competency levels in general biology. The mean science achievement of each of the two groups was tested for statistical significance using the t-test. In the two schools the t-test statistic showed significant difference between the pretest and a slight statistical difference on the posttest; the preferred analysis was an ANCOVA used to compare the posttest scores using the pretest as a covariate. The data implies that attitudes and perceptions are basically the same in both environments with minor differences. Results of these analyses suggest

  6. New Philadelphia, Illinois, Study Act

    THOMAS, 112th Congress

    Sen. Kirk, Mark Steven [R-IL

    2011-11-17

    11/17/2011 Read twice and referred to the Committee on Energy and Natural Resources. (text of measure as introduced: CR S7711-7712) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. New Philadelphia, Illinois, Study Act

    THOMAS, 113th Congress

    Rep. Schock, Aaron [R-IL-18

    2013-02-28

    04/29/2014 Received in the Senate and Read twice and referred to the Committee on Energy and Natural Resources. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  8. Affective Parent Education in Philadelphia.

    ERIC Educational Resources Information Center

    Gibson, Jessie M.

    It is apparent that the family, and the parents in particular, are powerful influences on the child's learning, even before the child reaches school. The home is the place where children learn first, and the extent to which they learn later in life is determined greatly by what goes on at home. The Affective Education Program, a Title I funded…

  9. The Stephen H. Long Expedition (1819?1820), Titian R. Peale?s field illustrations, and the lost holotypes of the North American shrews Sorex brevicaudus Say and Sorex parvus Say (Mammalia: Soricidae) from the Philadelphia Museum

    USGS Publications Warehouse

    Woodman, N.

    2009-01-01

    While encamped for the winter of 1819?1820 at Engineer Cantonment along the Missouri River in present-day eastern Nebraska, members of Major Stephen Harriman Long?s Expedition to the Rocky Mountains collected a number of animals that were previously unknown. Among the mammals were two soricids that were subsequently described by Thomas Say as Sorex brevicaudus (Northern Short-tailed Shrew, Blarina brevicauda) and Sorex parvus (Least Shrew, Cryptotis parvus). The holotypes of these species were deposited and placed on public exhibit in the Philadelphia Museum, the predominant North American systematic collection of the early nineteenth century. Like most private museums of that era, the Philadelphia Museum eventually went out of business, and its collections were dispersed and, for the most part, lost. Fortunately, Titian R. Peale made a detailed field sketch of the two specimens soon after their capture and subsequently executed a watercolor based on that sketch. In addition, an engraving of the holotypes was published in the decade following the discovery of the two species. Illustrations of holotypes are taxonomically useful when they depict diagnostic characters of species. They take on added taxonomic significance in the absence of the holotypes. In the cases of Sorex brevicaudus and Sorex parvus, pictures provide strong confirmation of the taxonomic identities of these two species, as well as recording the early history of the specimens.

  10. Allo-SCT for  Philadelphia-negative myeloproliferative neoplasms in blast phase: a study from the Societe Française de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC).

    PubMed

    Cahu, X; Chevallier, P; Clavert, A; Suarez, F; Michallet, M; Vincent, L; Vigouroux, S; Blaise, D; Mariette, C; Bilger, K; Robin, M; Yakoub-Agha, I; Peffault de Latour, R; Mohty, M

    2014-06-01

    Progression of Philadelphia-negative myeloproliferative (MPN) or myelodysplastic/myeloproliferative neoplasms (MDS/MPN) to acute myeloid leukemia (AML) is an adverse event in the course of the disease. Although allogeneic hematopoietic SCT (allo-SCT) is considered as the only curative therapy, few data exist on the outcome of patients with Philadelphia-negative MPN or MDS/MPN in blast phase who received an allo-SCT. Sixty patients were included in this retrospective study. AML was secondary to an MPN in 43 cases, whereas AML evolved from an MDS/MPN in 17 cases. Patients received allo-SCT in CR or advanced disease in 26 cases and 34 cases, respectively. With a median follow-up of 31 months (range, 25-44), OS and leukemia-free survival (LFS) were, respectively, 18% and 9% at 3 years. CR at transplant was associated with an improved LFS in univariate and multivariate analysis. The 3-year LFS was 18% for patients undergoing allo-SCT in CR versus 3% in advanced disease (P=0.008). Absence of thrombosis and an intermediate or favorable AML karyotype were associated with an improved outcome for patients who received allo-SCT in CR. New strategies are needed to improve the outcome of patients with MPN-MDS/MPN in blast phase.

  11. EDITORIAL: Adaptive and active materials: Selected papers from the ASME 2010 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 10) (Philadelphia, PA, USA, 28 September-1 October 2010) Adaptive and active materials: Selected papers from the ASME 2010 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 10) (Philadelphia, PA, USA, 28 September-1 October 2010)

    NASA Astrophysics Data System (ADS)

    Brei, Diann

    2011-09-01

    The third annual meeting of the AMSE/AIAA Smart Materials, Adaptive Structures and Intelligent Systems Conference (SMASIS) took place in the heart of historic Philadelphia's cultural district, and included a pioneer banquet in the National Constitutional Center. The applications emphasis of the 2010 conference was reflected in keynote talks by Dr Alan Taub, vice president of General Motors global research and development, 'Smart materials in the automotive industry'; Dr Charles R Farrar, engineering institute leader at Los Alamos National Laboratory, 'Future directions for structural health monitoring of civil engineering infrastructure'; and Professor Christopher S Lynch of the University of California Los Angeles, 'Ferroelectric materials and their applications'. The SMASIS conference was divided into six technical symposia each of which included basic research, applied technological design and development, and industrial and governmental integrated system and application demonstrations. The six symposia were: SYMP 1 Multifunctional Materials; SYMP 2 Active Materials, Mechanics and Behavior; SYMP 3 Modeling, Simulation and Control; SYMP 4 Enabling Technologies and Integrated System Design; SYMP 5 Structural Health Monitoring/NDE; and SYMP 6 Bio-inspired Smart Materials and Structures. In addition, the conference introduced a new student and young professional development symposium. Authors of papers in the materials areas (symposia 1, 2 and 6) were invited to write a full journal article on their presentation topic for publication in this special issue of Smart Materials and Structures. This set of papers demonstrates the exceptional quality and originality of the conference presentations. We are appreciative of their efforts in producing this collection of highly relevant articles on smart materials.

  12. T-cell-rich HLA-haploidentical hematopoietic stem cell transplantation for relapsed/refractory pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia without posttransplant tyrosine kinase inhibitor therapy.

    PubMed

    Sano, Hideki; Mochizuki, Kazuhiro; Akaihata, Mitsuko; Kobayashi, Shogo; Ohto, Hitoshi; Kikuta, Atsushi

    2017-03-01

    Intensive chemotherapy with tyrosine kinase inhibitor (TKI) improves the prognosis of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL). However, the prognosis of cases of relapsed or refractory Ph-ALL remains poor. Here, we aimed to assess the efficacy of T-cell-rich HLA-haploidentical hematopoietic stem cell transplantation (TCR-haplo-HSCT) in eight patients with relapsed or refractory pediatric Ph-ALL. Transplant-related mortality was observed in two patients. All patients discontinued TKI after receiving TCR-haplo-HSCT. The 3-year probability of overall survival and event-free survival was 75.0 and 62.5%, respectively. These results indicate the efficacy of TCR-haplo-HSCT for relapsed/refractory pediatric Ph-ALL.

  13. The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia.

    PubMed

    Lee, Seok; Kim, Yoo-Jin; Min, Chang-Ki; Kim, Hee-Je; Eom, Ki-Sung; Kim, Dong-Wook; Lee, Jong-Wook; Min, Woo-Sung; Kim, Chun-Choo

    2005-05-01

    Previously, we suggested that imatinib incorporation into conventional chemotherapy as an alternative (imatinib interim therapy) might be a useful strategy for bridging the time to allogeneic stem cell transplantation (SCT) for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL). Here, we provide an updated report on this strategy in 29 patients. At the time of enrollment, 23 patients (79.3%) achieved complete remission (CR). After the first imatinib cycle, the median breakpoint cluster region-Abelson oncogene locus (BCR-ABL)/ABL ratios decreased by 0.77 log in 25 (86.2%) responders, and their BCR-ABL/ABL ratios decreased further by 0.34 log after the second imatinib cycle, which included 7 molecular CR. One patient (4.3%) relapsed during the imatinib therapy. The remaining 3 patients were primarily refractory to both imatinib and chemotherapy. Twenty-five (86.2%) of the 29 patients received transplants in first CR. With a median follow-up duration of 25 months after SCT, the 3-year estimated probabilities of relapse, nonrelapse mortality, disease-free survival, and overall survival were 3.8%, 18.7%, 78.1%, and 78.1%, respectively. In comparison to our historical control data, first-line imatinib interim therapy appears to provide a good quality of CR and a survival advantage for patients with Ph(+) ALL. Further long-term follow-up is needed to validate the results of this study.

  14. A Multiplex Snapback Primer System for the Enrichment and Detection of JAK2 V617F and MPL W515L/K Mutations in Philadelphia-Negative Myeloproliferative Neoplasms

    PubMed Central

    Zhang, Yunqing; Zhang, Xinju; Xu, Xiao; Kang, Zhihua; Li, Shibao; Zhang, Chen; Su, Bing

    2014-01-01

    A multiplex snapback primer system was developed for the simultaneous detection of JAK2 V617F and MPL W515L/K mutations in Philadelphia chromosome- (Ph-) negative myeloproliferative neoplasms (MPNs). The multiplex system comprises two snapback versus limiting primer sets for JAK2 and MPL mutation enrichment and detection, respectively. Linear-After exponential (LATE) PCR strategy was employed for the primer design to maximize the amplification efficiency of the system. Low ionic strength buffer and rapid PCR protocol allowed for selective amplification of the mutant alleles. Amplification products were analyzed by melting curve analysis for mutation identification. The multiplex system archived 0.1% mutation load sensitivity and <5% coefficient of variation inter-/intra-assay reproducibility. 120 clinical samples were tested by the multiplex snapback primer assay, and verified with amplification refractory system (ARMS), quantitative PCR (qPCR) and Sanger sequencing method. The multiplex system, with a favored versatility, provided the molecular diagnosis of Ph-negative MPNs with a suitable implement and simplified the genetic test process. PMID:24729973

  15. Establishment and characterization of A novel Philadelphia-chromosome positive chronic myeloid leukemia cell line, TCC-S, expressing P210 and P190 BCR/ABL transcripts but missing normal ABL gene.

    PubMed

    Van, Phan Nguyen Thanh; Xinh, Phan Thi; Kano, Yasuhiko; Tokunaga, Katsushi; Sato, Yuko

    2005-03-01

    A novel Philadelphia-chromosome positive (Ph+) cell line, TCC-S, has been established from a patient with Ph+ chronic myeloid leukemia (CML) in the blastic crisis. TCC-S cells were shown to express both P210 and P190 BCR/ABL transcripts by reverse transcriptase-polymerase chain reaction (PCR), although quantitative-PCR revealed that TCC-S cells mainly expressed P210 BCR/ABL transcript. Karyotype analysis revealed several triploid clones which constantly harbored two der(9)del(9) (p12)t(9;22) (q34;qll)s and two del(9) (q21)s. The der(9)del(9) (p12)t(9;22) (q34;q11) is rarely found in other CML cell lines. Moreover, to the best of our knowledge, del(9) (q21) resulting in missing of a restrict region including normal ABL gene has not been found among CML cell lines previously described. Thus, TCC-S cells with only BCR/ABL gene and no normal ABL gene may be a useful tool for functional study of ABL in Ph+ CML.

  16. PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation.

    PubMed

    Mian, A A; Rafiei, A; Haberbosch, I; Zeifman, A; Titov, I; Stroylov, V; Metodieva, A; Stroganov, O; Novikov, F; Brill, B; Chilov, G; Hoelzer, D; Ottmann, O G; Ruthardt, M

    2015-05-01

    Targeting BCR/ABL with tyrosine kinase inhibitors (TKIs) is a proven concept for the treatment of Philadelphia chromosome-positive (Ph+) leukemias. Resistance attributable to either kinase mutations in BCR/ABL or nonmutational mechanisms remains the major clinical challenge. With the exception of ponatinib, all approved TKIs are unable to inhibit the 'gatekeeper' mutation T315I. However, a broad spectrum of kinase inhibition increases the off-target effects of TKIs and may be responsible for cardiovascular issues of ponatinib. Thus, there is a need for more selective options for the treatment of resistant Ph+ leukemias. PF-114 is a novel TKI developed with the specifications of (i) targeting T315I and other resistance mutations in BCR/ABL; (ii) achieving a high selectivity to improve safety; and (iii) overcoming nonmutational resistance in Ph+ leukemias. PF-114 inhibited BCR/ABL and clinically important mutants including T315I at nanomolar concentrations. It suppressed primary Ph+ acute lymphatic leukemia-derived long-term cultures that either displayed nonmutational resistance or harbor the T315I. In BCR/ABL- or BCR/ABL-T315I-driven murine leukemia as well as in xenograft models of primary Ph+ leukemia harboring the T315I, PF-114 significantly prolonged survival to a similar extent as ponatinib. Our work supports clinical evaluation of PF-114 for the treatment of resistant Ph+ leukemia.

  17. Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission.

    PubMed

    Nishiwaki, Satoshi; Inamoto, Yoshihiro; Sakamaki, Hisashi; Kurokawa, Mineo; Iida, Hiroatsu; Ogawa, Hiroyasu; Fukuda, Takahiro; Ozawa, Yukiyasu; Kobayashi, Naoki; Kasai, Masanobu; Mori, Takehiko; Iwato, Koji; Yoshida, Takashi; Onizuka, Makoto; Kawa, Keisei; Morishima, Yasuo; Suzuki, Ritsuro; Atsuta, Yoshiko; Miyamura, Koichi

    2010-11-18

    To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph(-) ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph(-) ALL patients using the registry data, particularly the details of 641 patients transplanted in CR1. Overall survival was significantly superior among patients transplanted in CR1, but no significant difference was observed between related and unrelated allo-SCTs (related vs unrelated: 65% vs 62% at 4 years, respectively; P = .19). Among patients transplanted in CR1, relapse rates were significantly higher in related allo-SCT compared with unrelated allo-SCT, and multivariate analysis demonstrated that less than 6 months from diagnosis to allo-SCT alone was associated with relapse. On the other hand, nonrelapse mortality (NRM) was significantly higher in unrelated allo-SCT compared with related allo-SCT, and multivariate analysis demonstrated that 10 months or longer from diagnosis to allo-SCT, human leukocyte antigen mismatch, and abnormal karyotype were associated with NRM. In conclusion, our study showed comparable survival rates but different relapse rates, NRM rates, and risk factors between related and unrelated allo-SCTs. After a close consideration of these factors, the outcome of allo-SCT for adult Ph(-) ALL in CR1 could be improved.

  18. Health care setting and severity, symptom burden, and complications in patients with Philadelphia-negative myeloproliferative neoplasms (MPN): a comparison between university hospitals, community hospitals, and office-based physicians.

    PubMed

    Kaifie, A; Isfort, S; Gattermann, N; Hollburg, W; Klausmann, M; Wolf, D; Maintz, C; Hänel, M; Goekkurt, E; Göthert, J R; Platzbecker, U; Geer, T; Parmentier, S; Jost, E; Serve, H; Ehninger, G; Berdel, W E; Brümmendorf, T H; Koschmieder, Steffen

    2016-09-01

    Philadelphia-negative myeloproliferative neoplasms (MPN) comprise a heterogeneous group of chronic hematological malignancies with significant variations in clinical characteristics. Due to the long survival and the feasibility of oral or subcutaneous therapy, these patients are frequently treated outside of larger academic centers. This analysis was performed to elucidate differences in MPN patients in three different health care settings: university hospitals (UH), community hospitals (CH), and office-based physicians (OBP). The MPN registry of the Study Alliance Leukemia is a non-interventional prospective study including adult patients with an MPN according to WHO criteria (2008). For statistical analysis, descriptive methods and tests for significant differences were used. Besides a different distribution of MPN subtypes between the settings, patients contributed by UH showed an impaired medical condition, a higher comorbidity burden, and more vascular complications. In the risk group analyses, the majority of polycythemia vera (PV) and essential thrombocythemia (ET) patients from UH were classified into the high-risk category due to previous vascular events, while for PV and ET patients in the CH and OBP settings, age was the major parameter for a high-risk categorization. Regarding MPN-directed therapy, PV patients from the UH setting were more likely to receive ruxolitinib within the framework of a clinical trial. In summary, the characteristics and management of patients differed significantly between the three health care settings with a higher burden of vascular events and comorbidities in patients contributed by UH. These differences need to be taken into account for further analyses and design of clinical trials.

  19. Emissions Offset Policy - City of Philadelphia

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  20. 28. Photographic copy of North, South, East Elevation (The Ballinger ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Photographic copy of North, South, East Elevation (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia. Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  1. 32. Photographic copy of Hangar Roof Framing Plan (Ammann and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Photographic copy of Hangar Roof Framing Plan (Ammann and Whitney and The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  2. 25. Photographic copy of First Floor Plan (The Ballinger Company, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Photographic copy of First Floor Plan (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  3. 27. Photographic copy of Mexxanine Plan, Roof Plan and Details ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Photographic copy of Mexxanine Plan, Roof Plan and Details (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  4. 31. Photographic copy of Leanto Roof Framing Plan & Bent ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Photographic copy of Leanto Roof Framing Plan & Bent Details (Ammann and Whitney and The Balinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E, Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  5. 29. Photographic copy of West Elevation and Sections Through Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Photographic copy of West Elevation and Sections Through Building (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia. Division of Aviation. Terminal E. Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  6. 26. Photographic copy of Second Floor Plan (The Ballinger Company, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Photographic copy of Second Floor Plan (The Ballinger Company, April 12, 1955), In files of the City of Philadelphia. Division of Aviation, Terminal E. Philadelphia International Airport. Reprinted with permission of Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  7. 35. Photographic copy of Hangar Door Canopy Details (Ammann and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. Photographic copy of Hangar Door Canopy Details (Ammann and Whitney and The Ballinger Company. April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E. Philadelphia International Airport. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  8. 30. Photographic copy of Wall Sections and Details (The Ballinger ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. Photographic copy of Wall Sections and Details (The Ballinger Company, April 12, 1955). In files of the City of Philadelphia, Division of Aviation, Terminal E. Philadelphia International Airport Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  9. Underwater Facilities Inspections and Assessments at Philadelphia Naval Shipyard, Philadelphia, Pennsylvania. Volume 3.

    DTIC Science & Technology

    1983-10-01

    length tie-back structure 2. Cut steel formwork flush 3. Repair separations in she, 4. Conduct 12 test borings 0 5. Investigate flume associa 6. Re...environment. Specific locations of honeycombing can be found on Figures 81 through 85. The formwork previously used in the construction of the seawall...remains in place along most of the seawall. Although the majority of the formwork does not protrude from the face of the concrete, in locations noted on

  10. Building America Case Study: Philadelphia Housing Authority Energy-Efficiency Turnover Protocols, Philadelphia, Pennsylvania

    SciTech Connect

    2016-02-01

    Over one million HUD-supported public housing units provide rental housing for eligible low-income families across the country. A survey of over 100 public housing authorities (PHAs) across the country indicated that there is a high level of interest in developing low-cost solutions that improve energy efficiency and can be seamlessly included in the refurbishment process. Further, PHAs, have incentives (both internal and external) to reduce utility bills. ARIES worked with four PHAs to develop packages of energy efficiency retrofit measures the PHAs can cost-effectively implement with their own staffs in the normal course of housing operations at the time when units are refurbished between occupancies. The energy efficiency turnover protocols emphasized air infiltration reduction, duct sealing, and measures that improve equipment efficiency. ARIES documented implementation in 18 housing units. Reductions in average air leakage were 16 percent and duct leakage reductions averaged 23 percent. Total source energy consumption savings due to implemented measures was estimated at 3-10 percent based on BEopt modeling with a simple payback of 1.6 to 2.5 years. Implementation challenges were encountered mainly related to required operational changes and budgetary constraints. Nevertheless, simple measures can feasibly be accomplished by PHA staff at low or no cost. At typical housing unit turnover rates, these measures could impact hundreds of thousands of units per year nationally.

  11. 15. VIEW OF SOUTHWEST END OF HANGAR, SHOWING FREESTANDING US ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. VIEW OF SOUTHWEST END OF HANGAR, SHOWING FREE-STANDING US AIR SHOP AREA. LOOKING SOUTHWEST. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  12. 8. DETAIL OF NORTHEAST ELEVATION SHOWING NEON TWA SIGN AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. DETAIL OF NORTHEAST ELEVATION SHOWING NEON TWA SIGN AND ROOF MASTS. LOOKING SOUTHWEST. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  13. Impact of minimal residual disease on outcomes after umbilical cord blood transplantation for adults with Philadelphia-positive acute lymphoblastic leukaemia: an analysis on behalf of Eurocord, Cord Blood Committee and the Acute Leukaemia working party of the European group for Blood and Marrow Transplantation.

    PubMed

    Tucunduva, Luciana; Ruggeri, Annalisa; Sanz, Guillermo; Furst, Sabine; Cornelissen, Jan; Linkesch, Werner; Mannone, Lionel; Ribera, Josep-Maria; Veelken, Hendrik; Yakoub-Agha, Ibrahim; González Valentín, Maria Elvira; Schots, Rik; Arcese, William; Montesinos, Pau; Labopin, Myriam; Gluckman, Eliane; Mohty, Mohamad; Rocha, Vanderson

    2014-09-01

    The status of umbilical cord blood transplantation (UCBT) in adults with Philadelphia-positive acute lymphoblastic leukaemia (Ph+ALL) and the impact of minimal residual disease (MRD) before transplant are not well established. We analysed 98 patients receiving UCBT for Ph+ALL in first (CR1) or second (CR2) complete remission (CR1, n = 79; CR2, n = 19) with MRD available before UCBT (92% analysed by reverse transcription polymerase chain reaction). Median age was 38 years and median follow-up was 36 months; 63% of patients received myeloablative conditioning and 42% received double-unit UCBT. Eighty-three patients were treated with at least one tyrosine kinase inhibitor before UCBT. MRD was negative (-) in 39 and positive (+) in 59 patients. Three-year cumulative incidence of relapse was 34%; 45% in MRD+ and 16% in MRD- patients (P =0·013). Three-year cumulative incidence of non-relapse mortality was 31%; it was increased in patients older than 35 years (P = 0·02). Leukaemia-free survival (LFS) at 3 years was 36%; 27% in MRD+ and 49% in MRD- patients (P = 0·05), and 41% for CR1 and 14% for CR2 (P = 0·008). Multivariate analysis identified only CR1 as being associated with improved LFS. In conclusion, MRD+ before UCBT is associated with increased relapse. Strategies to decrease relapse in UCBT recipients with Ph+ALL and MRD+ are needed.

  14. A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy

    PubMed Central

    Borthakur, Gautam; Dombret, Herve; Schafhausen, Philippe; Brummendorf, Tim Henrik; Boissel, Nicolas; Jabbour, Elias; Mariani, Mariangela; Capolongo, Laura; Carpinelli, Patrizia; Davite, Cristina; Kantarjian, Hagop; Cortes, Jorge E.

    2015-01-01

    Danusertib is a pan-aurora kinase inhibitor with potent activity against Abl kinase including the gatekeeper T315I mutant. A phase 1 dose escalation study of danusertib was conducted in patients with accelerated or blastic phase chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Two dosing schedules were studied: schedule A, in which danusertib was given by 3-hour intravenous infusion daily for 7 consecutive days (days 1–7) in a 14-day cycle, and schedule B, in which the danusertib was given by 3-hour intravenous infusion daily for 14 consecutive days (days 1–14) in a 21-day cycle. A total of 37 patients were treated, 29 with schedule A and eight with schedule B. The recommended phase 2 dose for schedule A was 180 mg/m2. Enrollment to schedule B was stopped early because of logistical problems with the frequency of infusions. Febrile neutropenia and mucositis were dose-limiting toxicities in schedule A. Four patients with T315I ABL kinase mutation, all treated with schedule A, responded. Danusertib has an acceptable toxicity profile and is active in patients with Bcr-Abl-associated advanced hematologic malignancies. This study was registered with the European Clinical Trails Data Base (EudraCT number 2007-004070-18). PMID:25887498

  15. Intermediate dose of imatinib in combination with chemotherapy followed by allogeneic stem cell transplantation improves early outcome in paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL): results of the Spanish Cooperative Group SHOP studies ALL-94, ALL-99 and ALL-2005.

    PubMed

    Rives, Susana; Estella, Jesús; Gómez, Pedro; López-Duarte, Mónica; de Miguel, Purificación García; Verdeguer, Amparo; Moreno, Maria José; Vivanco, José Luis; Couselo, José Miguel; Fernández-Delgado, Rafael; Maldonado, Marisol; Tasso, María; López-Ibor, Blanca; Lendínez, Francisco; López-Almaraz, Ricardo; Uriz, Javier; Melo, Montserrat; Fernández-Teijeiro, Ana; Rodríguez, Isidoro; Badell, Isabel

    2011-09-01

    Philadelphia-chromosome acute lymphoblastic leukaemia (Ph+ ALL) is a subgroup of ALL with very high risk of treatment failure. We report here the results of the Sociedad Española de Hematología y Oncología Pediátricas (SEHOP/SHOP) in paediatric Ph+ ALL treated with intermediate-dose imatinib concurrent with intensive chemotherapy. The toxicities and outcome of these patients were compared with historical controls not receiving imatinib. Patients with Ph+ ALL aged 1-18years were enrolled in three consecutive ALL/SHOP trials (SHOP-94/SHOP-99/SHOP-2005). In the SHOP-2005 trial, imatinib (260mg/m(2) per day) was given on day-15 of induction. Allogeneic haematopoietic stem-cell transplantation (HSCT) from a matched related or unrelated donor was scheduled in first complete remission (CR1). Forty-three patients were evaluable (22 boys, median age 6·8years, range, 1·2-15). Sixteen received imatinib whereas 27 received similar chemotherapy without imatinib. Seventeen of 27 and 15 of 16 patients in the non-imatinib and imatinib cohort, respectively, underwent HSCT in CR1. With a median follow-up of 109 and 39months for the non-imatinib and imatinib cohorts, the 3-year event-free survival (EFS) was 29·6% and 78·7%, respectively (P=0·01). These results show that, compared to historical controls, intermediate dose of imatinib given concomitantly with chemotherapy and followed by allogeneic HSCT markedly improved early EFS in paediatric Ph+ ALL.

  16. Greater Philadelphia Bioinformatics Alliance (GPBA) 3rd Annual Retreat 2005

    DTIC Science & Technology

    2005-11-01

    annotations: Stem cells populations were annotated with a controlled vocabulary describing stem cell differentiation stages (multipotent, totipotent ...A modular analysis of a stem cells populations compendium. Ghislain Bidaut and Christian J. Stoeckert Jr...92 70 PI. A modular analysis of a stem cells populations compendium. Ghislain Bidaut and Christian J

  17. 77 FR 47792 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... from the Conrail Bridge to the CSX Bridge. DATES: Comments and related material must reach the Coast... proposes to change the regulations that govern the operation of the Conrail Bridge over the Schuylkill... current regulation to reflect a change in name of the bridge and to meet the current lack of demand...

  18. Benjamin Franklin, Philadelphia's favorite son, was a membrane biophysicist.

    PubMed

    Wang, Da-Neng; Stieglitz, Heather; Marden, Jennifer; Tamm, Lukas K

    2013-01-22

    Benjamin Franklin, mostly known for his participation in writing The Declaration of Independence and work on electricity, was also one of the first scientists to seek to understand the properties of oil monolayers on water surfaces. During one of his many voyages across the Atlantic Ocean, Franklin observed that oil had a calming effect on waves when poured into rough ocean waters. Though at first taking a backseat to many of his other scientific and political endeavors, Franklin went on to experiment with oil, spreading monomolecular films on various bodies of water, and ultimately devised a concept of particle repulsion that is indirectly related to the hydrophobic effect. His early observations inspired others to measure the dimensions of oil monolayers, which eventually led to the formulation of the contemporary lipid bilayer model of the cell membrane.

  19. Food insecurity, neighborhood food access, and food assistance in Philadelphia.

    PubMed

    Mayer, Victoria L; Hillier, Amy; Bachhuber, Marcus A; Long, Judith A

    2014-12-01

    An estimated 17.6 million American households were food insecure in 2012, meaning they were unable to obtain enough food for an active and healthy life. Programs to augment local access to healthy foods are increasingly widespread, with unclear effects on food security. At the same time, the US government has recently enacted major cuts to federal food assistance programs. In this study, we examined the association between food insecurity (skipping or reducing meal size because of budget), neighborhood food access (self-reported access to fruits and vegetables and quality of grocery stores), and receipt of food assistance using the 2008, 2010, and 2012 waves of the Southeastern Pennsylvania Household Health Survey. Of 11,599 respondents, 16.7% reported food insecurity; 79.4% of the food insecure found it easy or very easy to find fruits and vegetables, and 60.6% reported excellent or good quality neighborhood grocery stores. In our regression models adjusting for individual- and neighborhood-level covariates, compared to those who reported very difficult access to fruits and vegetables, those who reported difficult, easy or very easy access were less likely to report food insecurity (OR 0.62: 95% CI 0.43-0.90, 0.33: 95% CI 0.23-0.47, and 0.28: 95% CI 0.20-0.40). Compared to those who reported poor stores, those who reported fair, good, and excellent quality stores were also less likely to report food insecurity (OR 0.81: 95% CI 0.60-1.08, 0.58: 95% CI 0.43-0.78, and 0.43: 95% CI 0.31-0.59). Compared to individuals not receiving food assistance, those receiving Supplemental Nutrition Assistance Program (SNAP) benefits were significantly more likely to be food insecure (OR 1.36: 95% CI 1.11-1.67), while those receiving benefits from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) (OR 1.17: 95% CI 0.77-1.78) and those receiving both SNAP and WIC (OR 0.84: 95% CI 0.61-1.17) did not have significantly different odds of food insecurity. In conclusion, better neighborhood food access is associated with lower risk of food insecurity. However, most food insecure individuals reported good access. Improving diet in communities with high rates of food insecurity likely requires not only improved access but also greater affordability.

  20. 77 FR 63727 - Drawbridge Operation Regulation; Schuylkill River, Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... government and the States, or on the distribution of power and responsibilities among the various levels of..., or on the distribution of power and responsibilities between the Federal Government and Indian tribes... Regulations That Significantly Affect Energy Supply, Distribution, or Use. We have determined that it is not...

  1. [From conventional cytogenetics to microarrays. Fifty years of Philadelphia chromosome].

    PubMed

    Hernández, Jesús M; Granada, Isabel; Solé, Francesc

    2011-07-23

    In 1960 Ph-chromosome was found associated with the presence of chronic myelogenous leukemia. In these 50 years an increasing number of cytogenetic abnormalities have been found associated with hematological malignancies. The presence of these abnormalities is not only important for the diagnosis of the patient, but it also contributes to the prognosis of patients with leukemia or lymphoma. For this reason the WHO classification of hematological disease has included these studies for the correct characterization of leukemias and lymphomas. In addition, the use of FISH and micromatrix methodologies have refined the genetic lesions present in these malignancies. The cytogenetic changes observed also provide further information in relation to the therapy.

  2. Watershed Central: Dynamic Collaboration for Improving Watershed Management (Philadelphia)

    EPA Science Inventory

    The Watershed Central web and wiki pages will be presented and demonstrated real-time as part of the overview of Web 2.0 collaboration tools for watershed management. The presentation portion will discuss how EPA worked with watershed practitioners and within the Agency to deter...

  3. Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study

    ClinicalTrials.gov

    2017-04-06

    Glaucoma; Glaucoma Suspect; Diabetic Retinopathy; Ocular Hypertension; Cataract; Branch Retinal Vein Occlusion; Branch Retinal Arterial Occlusion; Central Retinal Vein Occlusion; Central Retinal Artery Occlusion; Epi-retinal Membrane; Macular Degeneration; Drusen; Loss of Vision

  4. Ocular vaccinia infection in laboratory worker, Philadelphia, 2004.

    PubMed

    Lewis, Felicia M T; Chernak, Esther; Goldman, Erinn; Li, Yu; Karem, Kevin; Damon, Inger K; Henkel, Richard; Newbern, E Claire; Ross, Patrina; Johnson, Caroline C

    2006-01-01

    We report a case of ocular vaccinia infection in an unvaccinated laboratory worker. The patient was infected by a unique strain used in an experiment performed partly outside a biosafety cabinet. Vaccination should continue to be recommended, but laboratories with unvaccinated workers should also implement more stringent biosafety practices.

  5. The Philadelphia Open Classroom Project. Technical Report 24.2.

    ERIC Educational Resources Information Center

    Bartel, Nettie R.

    As part of an ongoing study of handicapped children in the open classroom, 12 children (in grades K through 4) were observed who had been identified by their teachers as either benefiting most or least from open class instruction. The literature review of the entire study focused on the critical variables (teachers' roles, individual differences,…

  6. A century of endodontics: from Philadelphia to Boston.

    PubMed

    Millstein, Charles B

    2010-01-01

    While Dr. Grossman was in Rostock with a letter of introduction from Dr. Prinz, he visited several distinguished dentists in Berlin. One was the aged Dr. Otto Walkoff, who, with the help of a physicist while in Wurzberg, was the first dentist to capture the image of a tooth soon after the discovery of radiology by Roentgen in 1895. At his home, Dr. Walkoff passed the X-ray tube head that had taken the historic film to Dr. Grossman, who then held this treasured artifact in his hands. This transfer of culture from Germany to the United States marked the beginning of modern endodontics. Similarly, when Dr. Goldman gave Dr. Schilder his backing by sending him to study under Dr. Grossman at the University of Pennsylvania, the progress of endodontic excellence moved forward, ensuring a Century of Endodontics.

  7. Flying High in Philadelphia. "Congress Shall Make No Law. . ."

    ERIC Educational Resources Information Center

    Piel, Gerard

    1976-01-01

    Reviews congressional appropriations which have led to the development of science education curriculum materials and science teacher education. Describes the present reluctance of Congress to appropriate more funds for additional efforts. (CP)

  8. Molecular Analysis Research at Community College of Philadelphia

    DTIC Science & Technology

    2015-09-21

    projects presented below fall under the category of "molecular genetics ", as presented in ARO Solicitation Number W911NF-12-R-0012-01. These projects...role of the GADD45 family of genes in innate immunity and sepsis. In addition to studying genetic components of the molecular response of myeloid...Equipment in left  column, procedure in right column.  kinetics of these molecular signaling pathways in genetic variants (gene KO models) has yet to

  9. Reverse Engineering Course at Philadelphia University in Jordan

    ERIC Educational Resources Information Center

    Younis, M. Bani; Tutunji, T.

    2012-01-01

    Reverse engineering (RE) is the process of testing and analysing a system or a device in order to identify, understand and document its functionality. RE is an efficient tool in industrial benchmarking where competitors' products are dissected and evaluated for performance and costs. RE can play an important role in the re-configuration and…

  10. Making the Most of Interim Assessment Data. Lessons from Philadelphia

    ERIC Educational Resources Information Center

    Christman, Jolley Bruce; Neild, Ruth Curran; Bulkley, Katrina; Blanc, Suzanne; Liu, Roseann; Mitchell, Cecily; Travers, Eva

    2009-01-01

    Under No Child Left Behind, urban school districts have increasingly turned to interim assessments, administered at regular intervals, to help gauge student progress in advance of annual state exams. These assessments have spawned growing debate among educators, assessment experts, and the testing industry: are they worth the significant…

  11. Obesity and Other Predictors of Absenteeism in Philadelphia School Children

    ERIC Educational Resources Information Center

    Rappaport, Elizabeth B.; Daskalakis, Constantine; Andrel, Jocelyn

    2011-01-01

    Background: Limited data indicate that obese children are absent from school more than their normal-weight peers. We analyzed administrative data from a large urban school district to investigate the association of obesity and student sociodemographic characteristics with absenteeism. Methods: We analyzed 291,040 records, representing 165,056…

  12. Case Study: Philadelphia. Needle-Moving Community Collaboratives

    ERIC Educational Resources Information Center

    Seldon, Willa; Jolin, Michele; Schmitz, Paul

    2012-01-01

    Communities face powerful challenges that require powerful solutions: a high-school dropout epidemic, youth unemployment, teen pregnancy. In an era of limited resources, those solutions must help communities to achieve more with less. A new kind of community collaborative--an approach that aspires to significant community-wide progress by…

  13. Teacher Networks in Philadelphia: Landscape, Engagement, and Value

    ERIC Educational Resources Information Center

    Schiff, Daniel; Herzog, Liza; Farley-Ripple, Elizabeth; Iannuccilli, Lauren Thum

    2015-01-01

    Teacher collaboration has become an increasingly important lever for school improvement efforts. This is especially true in high need urban districts, which struggle with capacity building in the face of significant teacher turnover, major shifts in curriculum and instruction, and scarce resources. This paper employs a mixed methods approach to…

  14. 17. Photographic copy of photograph of north elevation taken on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photographic copy of photograph of north elevation taken on March 22, 1957, photographer unknown. Original photograph property of the City of Philadelphia. Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  15. 20. Photographic copy of photograph of roof suspender system taken ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photographic copy of photograph of roof suspender system taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  16. 21. Photographic copy of photograph of interior of hangar looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Photographic copy of photograph of interior of hangar looking east taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  17. 19. Photographic copy of photograph of portion of east elevation ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Photographic copy of photograph of portion of east elevation taken on March 22, 1957 showing door beam and ladder to building roof. Photographer unknown. Original photograph property of the City of Philadelphia. Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  18. 24. Photographic copy of photograph of mezzanine, interior of hangar, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Photographic copy of photograph of mezzanine, interior of hangar, taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  19. 18. Photographic copy of photograph of south and east elevations ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Photographic copy of photograph of south and east elevations taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  20. 23. Photographic copy of photograph of interior of hangar looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photographic copy of photograph of interior of hangar looking south taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  1. 22. Photographic copy of photograph of interior of hangar looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Photographic copy of photograph of interior of hangar looking west taken on March 22, 1957. Photographer unknown. Original photograph property of the City of Philadelphia, Division of Aviation. Reprinted with permission of the Division of Aviation. - TWA Maintenance Hangar, South side of Tinicum Island Road, Philadelphia International Airport, Philadelphia, Philadelphia County, PA

  2. Airport noise

    NASA Technical Reports Server (NTRS)

    Pendley, R. E.

    1982-01-01

    The problem of airport noise at several airports and air bases is detailed. Community reactions to the noise, steps taken to reduce jet engine noise, and the effect of airport use restrictions and curfews on air transportation are discussed. The adverse effect of changes in allowable operational noise on airport safety and altenative means for reducing noise pollution are considered. Community-airport relations and public relations are discussed.

  3. Philadelphia's Teacher Hiring and School Assignment Practices. Comparisons with Other Districts. A Report from Learning from Philadelphia's School Reform

    ERIC Educational Resources Information Center

    Useem, Elizabeth; Farley, Elizabeth

    2004-01-01

    Many big-city school systems nationwide are modernizing, expediting, and decentralizing the ways in which teachers are recruited, hired, and placed in schools, as well as offering a range of new incentives to attract and retain teachers. Districts are rapidly adopting new employment processing technologies, notably automated applicant-tracking…

  4. A Statistically-Based Method for Predicting Fog and Stratus Dissipation

    DTIC Science & Technology

    2004-03-01

    Millville (NJ) Quantico, MCAF (VA) Belmar-Farmsdale (NJ) New York City, JFK (NY) Observing Station Dover AFB (DE) Wilmington (DE) Georgetown Suffox...Wilkes-Barre-Scranton International (PA) Millville Municipal Airport (NJ) Wilmington (DE) Allentown (PA) Philadelphia International Airport (PA...36 41 Langly AFB (VA) Charlottesville-Abermarle Airport (VA) Millville Municipal Airport (NJ) Reading Regional Airport (PA) Philadelphia International

  5. Whiffing the Airport Interview

    ERIC Educational Resources Information Center

    Williamson, David

    2008-01-01

    An airport interview is an initial interview for a senior administrative position conducted at an airport hotel not too far from the campus in question. Meeting at an airport enables a search committee to interview a large number of candidates in a short period of time with a degree of confidentiality. At the conclusion of the airport interviews,…

  6. Airport technology international 1993

    NASA Astrophysics Data System (ADS)

    Papagiorcopulo, George

    The present survey of developments in airport technologies and their management discusses airport extensions and upgradings, airport developments in China, polluter penalization, airport effects on environments, European ground-handling methods, ATC in Europe, EC duty-free sales at airports, and the privatization of airport security. Also discussed are airport advertising, new alternatives in air-cargo handling, ATC training, taxi-guidance systems, and the reduction of fuel consumption and emissions on the ground. (No individual items are abstracted in this volume)

  7. Management engineering (building no. 4), looking west along Porter Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Management engineering (building no. 4), looking west along Porter Avenue. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  8. Aircraft assembly shop plant no. 2, view looking east ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aircraft assembly shop plant no. 2, view looking east - northeast. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Aircraft Assembly Shop Plant, League Island, Philadelphia, Philadelphia County, PA

  9. View up from portal level inside of pyramidal structure toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View up from portal level inside of pyramidal structure toward pintle. - Naval Base Philadelphia-Philadelphia Naval Shipyard, 350-Ton Hammerhead Crane, League Island, Philadelphia, Philadelphia County, PA

  10. Methodology for Analysis, Modeling and Simulation of Airport Gate-waiting Delays

    NASA Astrophysics Data System (ADS)

    Wang, Jianfeng

    This dissertation presents methodologies to estimate gate-waiting delays from historical data, to identify gate-waiting-delay functional causes in major U.S. airports, and to evaluate the impact of gate operation disruptions and mitigation strategies on gate-waiting delay. Airport gates are a resource of congestion in the air transportation system. When an arriving flight cannot pull into its gate, the delay it experiences is called gate-waiting delay. Some possible reasons for gate-waiting delay are: the gate is occupied, gate staff or equipment is unavailable, the weather prevents the use of the gate (e.g. lightning), or the airline has a preferred gate assignment. Gate-waiting delays potentially stay with the aircraft throughout the day (unless they are absorbed), adding costs to passengers and the airlines. As the volume of flights increases, ensuring that airport gates do not become a choke point of the system is critical. The first part of the dissertation presents a methodology for estimating gate-waiting delays based on historical, publicly available sources. Analysis of gate-waiting delays at major U.S. airports in the summer of 2007 identifies the following. (i) Gate-waiting delay is not a significant problem on majority of days; however, the worst delay days (e.g. 4% of the days at LGA) are extreme outliers. (ii) The Atlanta International Airport (ATL), the John F. Kennedy International Airport (JFK), the Dallas/Fort Worth International Airport (DFW) and the Philadelphia International Airport (PHL) experience the highest gate-waiting delays among major U.S. airports. (iii) There is a significant gate-waiting-delay difference between airlines due to a disproportional gate allocation. (iv) Gate-waiting delay is sensitive to time of a day and schedule peaks. According to basic principles of queueing theory, gate-waiting delay can be attributed to over-scheduling, higher-than-scheduled arrival rate, longer-than-scheduled gate-occupancy time, and reduced gate

  11. Weatherization Innovation Pilot Program: Program Overview and Philadelphia Project Highlight (Fact Sheet)

    SciTech Connect

    Not Available

    2012-01-01

    Case Study with WIPP program overview, information regarding eligibility, and successes from Pennsylvania's Commission on Economic Opportunity (CEO) that demonstrate innovative approaches that maximize the benefit of the program. The Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) recently launched the Weatherization Innovation Pilot Program (WIPP) to accelerate innovations in whole-house weatherization and advance DOE's goal of increasing the energy efficiency and health and safety of homes of low-income families. Since 2010, WIPP has helped weatherization service providers as well as new and nontraditional partners leverage non-federal financial resources to supplement federal grants, saving taxpayer money. WIPP complements the Weatherization Assistance program (WAP), which operates nation-wide, in U.S. territories and in three Native American tribes. 16 grantees are implementing weatherization innovation projects using experimental approaches to find new and better ways to weatherize homes. They are using approaches such as: (1) Financial tools - by understanding a diverse range of financing mechanisms, grantees can maximize the impact of the federal grant dollars while providing high-quality work and benefits to eligible low-income clients; (2) Green and healthy homes - in addition to helping families reduce their energy costs, grantees can protect their health and safety. Two WIPP projects (Connecticut and Maryland) will augment standard weatherization services with a comprehensive green and healthy homes approach; (3) New technologies and techniques - following the model of continuous improvement in weatherization, WIPP grantees will continue to use new and better technologies and techniques to improve the quality of work; (4) Residential energy behavior change - Two grantees are rigorously testing home energy monitors (HEMs) that display energy used in kilowatt-hours, allowing residents to monitor and reduce their energy use, and another is examining best-practices for mobile home energy efficiency; (5) Workforce development and volunteers - with a goal of creating a self-sustaining weatherization model that does not require future federal investment, three grantees are adapting business models successful in other sectors of the home performance business to perform weatherization work. Youthbuild is training youth to perform home energy upgrades to eligible clients and Habitat for Humanity is developing a model for how to incorporate volunteer labor in home weatherization. These innovative approaches will improve key weatherization outcomes, such as: Increasing the total number of homes that are weatherized; Reducing the weatherization cost per home; Increasing the energy savings in each weatherized home; Increasing the number of weatherization jobs created and retained; and Reducing greenhouse gas emissions.

  12. 76 FR 7236 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Boston Stock Exchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-09

    ... Stockholders' Agreement Between The NASDAQ OMX Group, Inc. and Investor AB February 3, 2011. Pursuant to... parent corporation, The NASDAQ OMX Group, Inc. (``NASDAQ OMX''), and Investor AB, a corporation organized... Investor AB also entered into the Investor Stockholders' Agreement, relating to 8 million shares of...

  13. Health hazard evaluation report No. HETA 82-272-1276, Boeing Vertol Company, Philadelphia, Pennsylvania

    SciTech Connect

    Chrostek, W.; Liss, G.M.; Moss, G.

    1983-03-01

    To evaluate employee health complaints, including anxiety, nausea, eye strain, and headache thought possibly related to working under high pressure sodium vapor (HPSV) lamps and working with storage boxes dipped in sulfur, air samples were collected in May and July 1982 for exposures to sulfates, sulfites, and sulfur dioxide. A calibrated photometer was used to measure illumination in units of lux. Self-administered questionnaires were completed. To further assess possible color distortion, investigators administered the Farnsworth-Munsell 100-Hue Test to 15 employees in Building 3-25. Environmental sampling found non-detectable levels of sulfite. The illumination levels in some parts of the building were far less than optimal. Although no serious adverse health effects were noted, symptoms related to the eyes and minor abnormalities of color discrimination, possibly related to HPSV lamps and exposure to sulfur containers, were detected. Recommendations to improve the lighting situation are presented.

  14. A resolution encouraging the Navy to commission the USS Somerset (LPD-25) in Philadelphia, Pennsylvania.

    THOMAS, 113th Congress

    Sen. Toomey, Pat [R-PA

    2013-02-28

    02/28/2013 Referred to the Committee on Armed Services. (text of measure as introduced: CR S1030) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  15. Using a Mystery-Caller Approach to Examine Access to Prostate Cancer Care in Philadelphia

    PubMed Central

    Pollack, Craig Evan; Ross, Michelle E.; Armstrong, Katrina; Branas, Charles C.; Rhodes, Karin V.; Bekelman, Justin E.; Wentz, Alicia; Stillson, Christian; Radhakrishnan, Archana; Oyeniran, Enny; Grande, David

    2016-01-01

    Purpose Prior work suggests that access to health care may influence the diagnosis and treatment of prostate cancer. Mystery-caller methods have been used previously to measure access to care for health services such as primary care, where patients’ self-initiate requests for care. We used a mystery-caller survey for specialized prostate cancer care to assess dimensions of access to prostate cancer care. Materials and Methods We created an inventory of urology and radiation oncology practices in southeastern Pennsylvania. Using a ‘mystery caller’ approach, a research assistant posing as a medical office scheduler in a primary care office, attempted to make a new patient appointment on behalf of a referred patient. Linear regression was used to determine the association between time to next available appointment with practice and census tract characteristics. Results We successfully obtained information on new patient appointments from 198 practices out of the 223 in the region (88.8%). Radiation oncology practices were more likely to accept Medicaid compared to urology practices (91.3% vs 36.4%) and had shorter mean wait times for new patient appointments (9.0 vs 12.8 days). We did not observe significant differences in wait times according to census tract characteristics including neighborhood socioeconomic status and the proportion of male African American residents. Conclusions Mystery-caller methods that reflect real-world referral processes from primary care offices can be used to measure access to specialized cancer care. We observed significant differences in wait times and insurance acceptance between radiation oncology and urology practices. PMID:27723780

  16. Delta Pi Epsilon National Research Conference Proceedings (Philadelphia, Pennsylvania, November 10-12, 1994).

    ERIC Educational Resources Information Center

    Delta Pi Epsilon Society, Little Rock, AR.

    Selected papers are as follows: "Are Office Support Personnel Aware of the Ergonomical Issues Associated with Computer Keyboarding?" (Evans); "Background and Characteristics of Japanese Students Who Enroll in an American Two-Year Information Processing Program Taught in Japan" (Morgan, Wiggs); "Business Education's (BE)…

  17. 78 FR 17634 - Foreign-Trade Zone 35-Philadelphia, Pennsylvania; Application for Subzone; Teva Pharmaceuticals...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... Pharmaceuticals USA, Inc.; North Wales, Chalfont, Kutztown and Sellersville, Pennsylvania An application has been... of FTZ 35, requesting special-purpose subzone status for the facilities of Teva Pharmaceuticals...

  18. 77 FR 45290 - Proposed Modification of Class B Airspace Area; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... the PHL Class B. The original purpose of this area was to allow aircraft inbound to LaGuardia, Newark... vectored for the ILS approach to Runway 17 at PHL. Today, aircraft inbound to PHL in this area are... that the benefits of the intended regulation justify its costs. Second, the Regulatory Flexibility...

  19. Organization and Administration of the Duplicate School in Philadelphia, Pa. Bulletin, 1924, No. 24

    ERIC Educational Resources Information Center

    Montanye, Edwin Y.

    1924-01-01

    The educational advantages and the housing economies effected by the work-study-play plan have led administrative officers to adopt some form of this organization in many school systems. The plan is variously designated as the "platoon plan," "alternating school," "companion class method," or "duplicate…

  20. 78 FR 40399 - Safety Zone; Fifth Coast Guard District Fireworks Displays, Delaware River; Philadelphia, PA.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... latitude 39 56'29.1'' N, longitude 075 07'56.5'' W, and bounded on the north by the Benjamin Franklin...; thence to latitude 39 56'29.1'' N, longitude 075 07'56.5'' W, and bounded on the north by the Benjamin Franklin Bridge. This safety zone will restrict general navigation in the regulated area during...

  1. Preparation of Urban High School Leaders in Philadelphia through Multiorganizational Partnerships

    ERIC Educational Resources Information Center

    Kaimal, Girija; Barber, Margaret; Schulman, Marcia; Reed, Pete

    2012-01-01

    Partnerships between universities and school districts are increasingly being identified as a means to overcome the difficulties of preparing the next generation of urban high school principals. This article examines the development of such a multiorganizational partnership with a large urban school district, two universities, and a national…

  2. An Evaluation of Health and Safety Hazards in Family Based Day Care Homes in Philadelphia

    ERIC Educational Resources Information Center

    Perez, Hernando; Haynes, Sonia; Michael, Karen; Burstyn, Igor; Jandhyala, Malica; Palermo, Peter

    2011-01-01

    In Pennsylvania, Family Day Care Homes (FDCH) are private residences used to care for up to six children in a 24 h period. These homes are often times the most affordable alternative to day care centers parents have in low-income communities. The aims of this study were to evaluate FDCH providers' knowledge of hazards and their understanding of…

  3. Designing School 2.0: A Study of Philadelphia's Science Leadership Academy

    ERIC Educational Resources Information Center

    Lehmann, Chris

    2007-01-01

    Sooner or later, every teacher and administrator fantasizes about starting a school of their own. Few, however, move from off-the-cuff theory to the practical steps required to open the school house doors to real students and teachers. Fewer still manage to start an urban high school of their own while only in their mid-30s, a school that manages…

  4. Alcohol outlet density and related use in an urban Black population in Philadelphia public housing communities

    PubMed Central

    Cederbaum, Julie A.; Petering, Robin; Hutchinson, M. Katherine; He, Amy S.; Wilson, John P.; Jemmott, John B.; Jemmott, Loretta Sweet

    2014-01-01

    Adolescent alcohol use behaviors are influenced by familial patterns and neighborhood factors. This work explored the influence of individual, family, and environment on alcohol use. Baseline data from a randomized controlled trial with Black mothers son dyads (n=382) were paired with census tract and alcohol control board data. Among mothers, younger age, along with neighborhood factors of alcohol outlet density, race, and education were significantly associated with use. Among sons, older age and alcohol outlet density in the neighborhood predicted use. Findings highlight neighborhood influence, beyond family qualities, as a significant determinant of disadvantaged Black mothers’ alcohol use. Implications for public health policy are discussed. PMID:25463915

  5. Michael F. Vaccaro Honors Attorney Fellowship Program in our Philadelphia (Region 3) Office

    EPA Pesticide Factsheets

    The Michael F. Vaccaro Honors Attorney Fellowship provides a unique opportunity to practice law in a major governmental environmental organization, and to receive extensive training in and exposure to environmental law and policy work in the public sector.

  6. Association of Lymphoid Malignancies and Philadelphia-Chromosome Negative Myeloproliferative Neoplasms: Clinical Characteristics, Therapy and Outcome

    PubMed Central

    Masarova, Lucia; Newberry, Kate J.; Pierce, Sherry A.; Estrov, Zeev; Cortes, Jorge E.; Kantarjian, Hagop M.; Verstovsek, Srdan

    2015-01-01

    The co-occurrence of myeloproliferative and lymphoproliferative neoplasms (MPN/LPN) has been reported, mostly in case reports. The aim of this study was to assess the characteristics and clinical course of the coexistent diseases. Among 9866 patients who presented to our institution from 1960 to 2014, 34 (0.3%) were diagnosed with MPN/LPN. LPN was diagnosed first in 16 patients, second in 15, and at the same time in 3. The time to secondary malignancy was longer when LPN was diagnosed first (119 vs 98 months). Myelofibrosis (41%), polycythemia vera (24%), and essential thrombocythemia (18%) were the most common MPNs, and non-Hodgkin lymphoma (50%) and chronic lymphocytic leukemia (32%) were the most common LPNs. Seventy-three percent of patients treated for MPN and 72% of those treated for LPN achieved a complete response. After a median follow-up from MPN diagnosis of 84 months, 16 patients are alive and 18 died (4 related to MPN and 2 LPN). Coexistent MPN/LPN is a rare event that does not appear to predict worse outcomes. Treatment choice is generally oriented towards controlling the prevalent disease; the other malignancy may influence treatment strategies in selected cases. PMID:26012362

  7. MEETING IN PHILADELPHIA: NUTRIENT CONCENTRATIONS IN FLOWING WATERS OF THE SOUTH FORK BROAD RIVER, GEORGIA WATERSHED

    EPA Science Inventory

    The objective of this poster is by comparing nutrient and DOM concentrations in small and large streams, we hope to better understand: (1) watershed controls on stream nutrient and DOM concentrations; and (2) the variability of nutrient and DOM concentrations within a river netwo...

  8. Influence of maternal health literacy on child participation in social welfare programs: the Philadelphia experience.

    PubMed

    Pati, Susmita; Mohamad, Zeinab; Cnaan, Avital; Kavanagh, Jane; Shea, Judy A

    2010-09-01

    We examined the influence of maternal health literacy on child participation in social welfare programs. In this cohort, 20% of the mothers had inadequate or marginal health literacy. Initially, more than 50% of the families participated in Temporary Assistance for Needy Families (TANF), the Food Stamp Program, and Special Supplemental Nutrition Program for Women, Infants, and Children, whereas fewer than 15% received child care subsidies or public housing. In multivariate regression, TANF participation was more than twice as common among children whose mothers had adequate health literacy compared with children whose mothers had inadequate health literacy.

  9. Influence of Maternal Health Literacy on Child Participation in Social Welfare Programs: The Philadelphia Experience

    PubMed Central

    Mohamad, Zeinab; Cnaan, Avital; Kavanagh, Jane; Shea, Judy A.

    2010-01-01

    We examined the influence of maternal health literacy on child participation in social welfare programs. In this cohort, 20% of the mothers had inadequate or marginal health literacy. Initially, more than 50% of the families participated in Temporary Assistance for Needy Families (TANF), the Food Stamp Program, and Special Supplemental Nutrition Program for Women, Infants, and Children, whereas fewer than 15% received child care subsidies or public housing. In multivariate regression, TANF participation was more than twice as common among children whose mothers had adequate health literacy compared with children whose mothers had inadequate health literacy. PMID:20634468

  10. Educational Work of the Commercial Museum of Philadelphia. Bulletin, 1920, No. 13

    ERIC Educational Resources Information Center

    Toothaker, Charles R.

    1921-01-01

    In industrial circles today the sciences and other subjects of a distinct practical nature are looked upon as more important than dead languages and classics; and as a result, technical trade, manual training, and commercial schools and colleges have increased in number, and added emphasis has been made in all schools on commerce and industries.…

  11. INFLUENCE OF ALTERNATIVE PM COMPONENTS IN MASS ASSOCIATIONS WITH PHILADELPHIA, PA MORTALITY AND HOSPITAL ADMISSIONS

    EPA Science Inventory

    Epidemiological analyses of hospital admissions and mortality data have indicated that adverse human health effects are associated with present-day ambient particualte matter (PM) pollution levels. However, the PM mass measurement is chemically non-specific, ignoring the fact th...

  12. Intelligent control and adaptive systems; Proceedings of the Meeting, Philadelphia, PA, Nov. 7, 8, 1989

    NASA Technical Reports Server (NTRS)

    Rodriguez, Guillermo (Editor)

    1990-01-01

    Various papers on intelligent control and adaptive systems are presented. Individual topics addressed include: control architecture for a Mars walking vehicle, representation for error detection and recovery in robot task plans, real-time operating system for robots, execution monitoring of a mobile robot system, statistical mechanics models for motion and force planning, global kinematics for manipulator planning and control, exploration of unknown mechanical assemblies through manipulation, low-level representations for robot vision, harmonic functions for robot path construction, simulation of dual behavior of an autonomous system. Also discussed are: control framework for hand-arm coordination, neural network approach to multivehicle navigation, electronic neural networks for global optimization, neural network for L1 norm linear regression, planning for assembly with robot hands, neural networks in dynamical systems, control design with iterative learning, improved fuzzy process control of spacecraft autonomous rendezvous using a genetic algorithm.

  13. System manual for the University of Pennsylvania retrofitted solar heated Philadelphia row home (SolaRow)

    SciTech Connect

    Zinnes, I.; Lior, N.

    1980-05-01

    The University of Pennsylvania SolaRow house, an urban row home retrofitted for comfort and domestic hot water heating, was extensively instrumented for performance monitoring and acquisition of weather and solar radiation data. This report describes the heating and instrumentation systems, provides the details for instrumentation, piping and valve identification, and specifies the operation and maintenance of the heating and data acquisition systems. The following are included: (1) system flow diagrams; (2) valve and cable identification tables; (3) wiring diagrams; and (4) start-up, normal operation, shut-down, maintenance and trouble-shooting procedures. It thus provides the necessary technical information to permit system operation and monitoring, overall system performance analysis and optimization, and acquisition of climatological data.

  14. Mobile robots IV; Proceedings of the Meeting, Philadelphia, PA, Nov. 6, 7, 1989

    SciTech Connect

    Wolfe, W.J.; Chun, W.H.

    1990-01-01

    The present conference on mobile robot systems discusses high-speed machine perception based on passive sensing, wide-angle optical ranging, three-dimensional path planning for flying/crawling robots, navigation of autonomous mobile intelligence in an unstructured natural environment, mechanical models for the locomotion of a four-articulated-track robot, a rule-based command language for a semiautonomous Mars rover, and a computer model of the structured light vision system for a Mars rover. Also discussed are optical flow and three-dimensional information for navigation, feature-based reasoning trail detection, a symbolic neural-net production system for obstacle avoidance and navigation, intelligent path planning for robot navigation in an unknown environment, behaviors from a hierarchical control system, stereoscopic TV systems, the REACT language for autonomous robots, and a man-amplifying exoskeleton.

  15. Physiological and Antigenic Characteristics of Virulent and Attenuated Strains of Legionella pneumophila (Philadelphia 3)

    DTIC Science & Technology

    1981-07-01

    Shepard. 1979. Virulent to avirulent conversion of Legionnaires ’ disease bacterium ( Legionella pneumophila) - its effect on isolation techniques. J...8217 disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova. Ann. Intern, Med. 90:656-658. 5...J. C. Feeley. 1978. A microagglutination test for detecting antibodies, p. 163-168. In C. L. Jones and G. A. Hebert (ed.), " Legionnaires " the disease

  16. Nivolumab and Dasatinib in Treating Patients With Relapsed or Refractory Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

    ClinicalTrials.gov

    2016-08-25

    B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Refractory Adult Acute Lymphoblastic Leukemia; Refractory Childhood Acute Lymphoblastic Leukemia

  17. Learning to Learn. Newspaper in Education Supplement, The Philadelphia Inquirer, Monday, January 12, 1987.

    ERIC Educational Resources Information Center

    Cummings, Alysa

    Aimed at classroom teachers interested in teaching learning skills to their elementary and secondary students, this guide offers an alternative to teaching "facts" that may rapidly become outdated. The guide is based on Dr. Leslie Hart's Proster Theory, which proposes that the brain requires large amounts of input to function; that after…

  18. Proceedings of the Symposium on Minimum Competency Testing (Philadelphia, Pennsylvania, October 24-25, 1979).

    ERIC Educational Resources Information Center

    Mid-Atlantic Teacher Corps Network, Philadelphia, PA.

    The conference's keynote address is presented by Bernard C. Watson. Papers include: Vantage from the State Department of Education, by Robert G. Scanlon (Pennsylvania); Minimum Competency: As the Public Sees the Question, by Jacqueline Grennan Wexler; Minimum Competency Testing (MCT): A Tripartite Response from the Profession, by W. James Popham;…

  19. 78 FR 36716 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Philadelphia County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... corresponding CTG document, except that the cold-weather was specified to a period of every year, November 1st... subject to the same limits regardless of weather conditions. \\e\\ VOC limits from EPA's CTG for Ship... dry basis corrected to 3 percent oxygen, whichever is less stringent; (2) combustion of the...

  20. Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome

    PubMed Central

    de Carvalho, Daiana Landenberger; Barbosa, Cristian Dias; de Carvalho, André Luiz; Beck, Sandra Trevisan

    2012-01-01

    Objective This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients. Methods Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME). Results Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3. Conclusion The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells. PMID:23049441

  1. 77 FR 59962 - John Heinz National Wildlife Refuge at Tinicum, DE and Philadelphia Counties, PA; Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... known as Tinicum Marsh, to promote environmental education, and to afford visitors an opportunity to... environmental education and interpretation in an urban setting. We announce our decision and the availability of..., and environmental education and interpretation. We will review and update the CCP at least every...

  2. ASSOCIATIONS BETWEEN TRACE ELEMENTAL COMPOSITION OF PM2.5 AND MORTALITY AND MORBIDITY IN PHILADELPHIA

    EPA Science Inventory

    A large number of studies have reported associations between particulate matter (PM) and mortality and morbidity. Since PM is a chemically non-specific index and a mixture of a variety of chemical components from multiple sources, it is possible that use of the total PM mass as ...

  3. 77 FR 3839 - Consolidated Rail Corporation-Abandonment Exemption-in Philadelphia, PA; CSX Transportation, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Surface Transportation Board [Docket No. AB 167 (Sub-No. 1191X); Docket No. AB 55 (Sub-No. 710X); Docket... such user) regarding cessation of service over the line either is pending with the Surface... conditions under 49 CFR 1152.28 must be filed by February 14, 2012, with the Surface Transportation...

  4. Educational Management Organizations as High Reliability Organizations: A Study of Victory's Philadelphia High School Reform Work

    ERIC Educational Resources Information Center

    Thomas, David E.

    2013-01-01

    This executive position paper proposes recommendations for designing reform models between public and private sectors dedicated to improving school reform work in low performing urban high schools. It reviews scholarly research about for-profit educational management organizations, high reliability organizations, American high school reform, and…

  5. Imatinib-induced thyroiditis in Philadelphia chromosome-positive chronic myeloid leukemia

    PubMed Central

    Singh, Surjit; Sharma, Pramod Kumar

    2016-01-01

    Here, we present a case of chronic myeloid leukemia for which imatinib therapy was initated. Triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone was normal, and thyroid microsomal autoantibodies (TMA) were positive and patient was diagnosed as thyroiditis treated with corticosteroids for 1½ months which lead to resolution. PMID:27756963

  6. A Postsecondary Transition Model for Low-Income, Minority Youth in Philadelphia

    ERIC Educational Resources Information Center

    Brown, Alexis Tolbert

    2016-01-01

    School administrators are in the best position, but often lack the knowledge, to help low-income, minority youth transition to college. Consequently, some youth are not meeting their full potential and there are long-term, deleterious consequences on local economies as wage earning potential stagnates. Using Aslanargun's, Farmer-Hinton's, and…

  7. 78 FR 75598 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... material monetary agreements, arrangements and understandings during the past three years, and any other... OMX believes this information will be useful in assessing the aims and incentives of Proposing Persons... interests in NASDAQ OMX and possible aims and incentives in submitting the proposed business...

  8. 77 FR 16854 - John Heinz National Wildlife Refuge at Tinicum, Delaware and Philadelphia Counties, PA; Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ..., open water, grassland, and forest habitats. It is an important migratory stopover for birds along the..., manage grassland habitats, and maintain dikes and water levels in the impoundment. Our environmental.... Alternative C Alternative C would focus on restoring degraded forests and converting specific grassland...

  9. SUMMERTIME AMBIENT FORMALDEHYDE IN FIVE U.S. METROPOLITAN AREAS: NASHVILLE, ATLANTA, HOUSTON, PHILADELPHIA, TAMPA

    EPA Science Inventory

    In this paper, we briefly review the atmospheric chemistry and previous intercomparison measurements for HCHO, with special reference to the diffusion scrubber-Hantzsch reaction based fluorescence instrument used in the field studies reported herein. Then we discuss summertime HC...

  10. 78 FR 39601 - Safety Zone, Sugar House Casino Fireworks Display, Delaware River; Philadelphia, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... action is necessary to provide for the safety of life and property in the navigable water. In addition... hazardous scenario with potential for loss of life and property. For the same reasons discussed in the... on the human environment. This rule is categorically excluded under 34(g) of Figure 2-1 of...

  11. 76 FR 25382 - Self-Regulatory Organizations; The Stock Clearing Corporation of Philadelphia; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... Parent Corporation, The NASDAQ OMX Group, Inc. April 27, 2011. Pursuant to Section 19(b)(1) of the... to amendments to the By-Laws of SCCP's parent corporation, The NASDAQ OMX Group, Inc. (``NASDAQ OMX... NASDAQ OMX to amend the By-Laws of its parent corporation. \\6\\ Id. NASDAQ OMX By-Laws previously...

  12. 78 FR 128 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... Proposed Rule Change With Respect to the Amendment of the By-Laws of Its Parent Corporation, The NASDAQ OMX... respect to the amendment of the by-laws of its parent corporation, The NASDAQ OMX Group, Inc. (``NASDAQ... member'' as follows: `` `Immediate family member' means a person's spouse, parents, children and...

  13. To charter an organization and establish a medal program to honor first responders in Philadelphia, Pennsylvania.

    THOMAS, 111th Congress

    Rep. Brady, Robert A. [D-PA-1

    2010-09-16

    12/20/2010 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  14. Advances in therapy for Philadelphia-positive acute lymphoblastic leukaemia of childhood and adolescence.

    PubMed

    Bleckmann, Kirsten; Schrappe, Martin

    2016-03-01

    The presence of the BCR/ABL1 fusion gene in childhood acute lymphoblastic leukaemia (ALL) is a rare finding and has been an adverse prognostic factor associated with a high risk of therapeutic failure. The current key components of treatment are intensive polychemotherapy and a BCR/ABL1 kinase domain inhibitor. This treatment approach has been applied in a few clinical trials by paediatric leukaemia study groups. Thus, this subtype of ALL serves as the first model system for truly targeted treatment. The role of haematopoietic stem cell transplantation (HSCT) is increasingly called into question, at least in a favourable, though not yet clearly defined, subset of patients. Currently, the choice of the most effective tyrosine kinase inhibitor is not yet settled, in particular, in view of potential reduction of overall treatment intensity.

  15. 70 FR 65956 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Order Granting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2005-11-01

    ... of a Proposed Rule Change Relating to Anonymous Features on Trading Systems October 21, 2005. I... allows SCCP to process trades executed on a trading system that provides for anonymous trading.\\3... an anonymous acronym instead of naming or identifying the actual contraside. \\3\\ SCCP's rule...

  16. 70 FR 46565 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2005-08-10

    ... Proposed Rule Change by Relating Anonymous Features on Trading Systems August 3, 2005. Pursuant to section... system that provides for anonymous trading.\\3\\ \\3\\ The proposed rule change is similar to a rule change... participants using an anonymous acronym instead of naming or identifying the actual contra side account...

  17. Framework for an Effective Assessment and Accountability Program: The Philadelphia Example

    ERIC Educational Resources Information Center

    Porter, Andrew C.; Chester, Mitchell D.; Schlesinger, Michael D.

    2004-01-01

    The purpose of this article is to put in the hands of researchers, practitioners, and policy makers a powerful framework for building and studying the effects of high-quality assessment and accountability programs. The framework is illustrated through a description and analysis of the assessment and accountability program in the School District of…

  18. Children and Families First: An Evaluation of the Philadelphia Say Yes to Education Program

    ERIC Educational Resources Information Center

    Gold, Eva; Hartmann, Tracey; Lewis, Kristine

    2005-01-01

    Say Yes to Education is a scholarship guarantee program that pledges to young children and their families a fully paid, post-secondary education along with academic and social supports that follow children throughout their elementary and high school careers. Since its inception in 1987, the Say Yes to Education program has "adopted"…

  19. An Undergraduate Mechatronics Project Class at Philadelphia University, Jordan: Methodology and Experience

    ERIC Educational Resources Information Center

    Tutunji, T. A.; Saleem, A.; Rabbo, S. A.

    2009-01-01

    Mechatronics is a branch of engineering whose final product should involve mechanical movements controlled by smart electronics. The design and implementation of functional prototypes are an essential learning experience for the students in this field. In this paper, the guidelines for a successful mechatronics project class are presented,…

  20. 75 FR 25010 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... directors (``Board''). Under Corporate Governance Guidelines adopted by the Board, however, any director in... purpose. \\7\\ NASDAQ OMX also amended its Corporate Governance Guidelines to reflect the majority vote... proposed making certain amendments to its By-Laws to make improvements in its governance. In...

  1. PHILADELPHIA AIR TOXICS STUDY: EVALUATION OF RISK MANAGEMENT OPTIONS USING MIRA

    EPA Science Inventory

    Evaluation of risk management options usually takes place within single programs at the U.S. EPA. This can produce inadvertent tradeoffs among important criteria by risk managers and other decision makers; resulting in decision surprises. This study is a demonstration of a diff...

  2. Influence of Socioeconomic Status on College Retention in Metro North Philadelphia

    ERIC Educational Resources Information Center

    Tolliver, Armando

    2013-01-01

    The purpose of this mixed methods study was to explore salient nonacademic factors related to social, economic, and cultural aspects together with traditional academic factors that influenced college retention. The study design employed a mixed-methods sequential explanatory method design, collecting quantitative data for correlation and…

  3. 77 FR 44299 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ...). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of the Substance of... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In its filing with the Commission, the Corporation included statements concerning the purpose of, and basis for,...

  4. Volcanic hazards to airports

    USGS Publications Warehouse

    Guffanti, M.; Mayberry, G.C.; Casadevall, T.J.; Wunderman, R.

    2009-01-01

    Volcanic activity has caused significant hazards to numerous airports worldwide, with local to far-ranging effects on travelers and commerce. Analysis of a new compilation of incidents of airports impacted by volcanic activity from 1944 through 2006 reveals that, at a minimum, 101 airports in 28 countries were affected on 171 occasions by eruptions at 46 volcanoes. Since 1980, five airports per year on average have been affected by volcanic activity, which indicates that volcanic hazards to airports are not rare on a worldwide basis. The main hazard to airports is ashfall, with accumulations of only a few millimeters sufficient to force temporary closures of some airports. A substantial portion of incidents has been caused by ash in airspace in the vicinity of airports, without accumulation of ash on the ground. On a few occasions, airports have been impacted by hazards other than ash (pyroclastic flow, lava flow, gas emission, and phreatic explosion). Several airports have been affected repeatedly by volcanic hazards. Four airports have been affected the most often and likely will continue to be among the most vulnerable owing to continued nearby volcanic activity: Fontanarossa International Airport in Catania, Italy; Ted Stevens Anchorage International Airport in Alaska, USA; Mariscal Sucre International Airport in Quito, Ecuador; and Tokua Airport in Kokopo, Papua New Guinea. The USA has the most airports affected by volcanic activity (17) on the most occasions (33) and hosts the second highest number of volcanoes that have caused the disruptions (5, after Indonesia with 7). One-fifth of the affected airports are within 30 km of the source volcanoes, approximately half are located within 150 km of the source volcanoes, and about three-quarters are within 300 km; nearly one-fifth are located more than 500 km away from the source volcanoes. The volcanoes that have caused the most impacts are Soufriere Hills on the island of Montserrat in the British West Indies

  5. Airport Activity Statistics of Certificated Route Air Carriers: Calendar Year 1989

    DTIC Science & Technology

    1989-01-01

    El Dorado/Camden Camden, NJ ...................-.............................................. Ph)Iiladelphia...84034 7373449 29517.13 6.36 11553.64 9.23 13 PHILADELPHIA,PAlCAMDEN, NJ (INTERNATIONAL)............. 1.45 82874 85627 82241 6247489 4499237 11.23...AIRLINES ................................ Domestc ......... S 242542 107.58 420.19 420.19 527.77 NJS 280 AS 242822 107.58 420.19 420.19 527.77 BN-BRANIFF

  6. Benchmark Airport Charges

    NASA Technical Reports Server (NTRS)

    de Wit, A.; Cohn, N.

    1999-01-01

    The Netherlands Directorate General of Civil Aviation (DGCA) commissioned Hague Consulting Group (HCG) to complete a benchmark study of airport charges at twenty eight airports in Europe and around the world, based on 1996 charges. This study followed previous DGCA research on the topic but included more airports in much more detail. The main purpose of this new benchmark study was to provide insight into the levels and types of airport charges worldwide and into recent changes in airport charge policy and structure. This paper describes the 1996 analysis. It is intended that this work be repeated every year in order to follow developing trends and provide the most up-to-date information possible.

  7. Integrated Airport Surface Operations

    NASA Technical Reports Server (NTRS)

    Koczo, S.

    1998-01-01

    The current air traffic environment in airport terminal areas experiences substantial delays when weather conditions deteriorate to Instrument Meteorological Conditions (IMC). Research activity at NASA has culminated in the development, flight test and demonstration of a prototype Low Visibility Landing and Surface Operations (LVLASO) system. A NASA led industry team and the FAA developed the system which integrated airport surface surveillance systems, aeronautical data links, DGPS navigation, automation systems, and controller and flight deck displays. The LVLASO system was demonstrated at the Hartsfield-Atlanta International Airport using a Boeing 757-200 aircraft during August, 1997. This report documents the contractors role in this testing particularly in the area of data link and DGPS navigation.

  8. 77 FR 23598 - Technical Amendment to Cuba Airport List: Addition of Recently Approved Airports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... Dallas/Fort Worth International Airport Fort Lauderdale-Hollywood International Airport Southwest Florida.../Fort Worth International Airport. Fort Lauderdale, Florida Fort Lauderdale-Hollywood...

  9. Airport Land Banking.

    DTIC Science & Technology

    1977-08-01

    the Secretary of Transportation to conduct a study with respect to the feasibility, practicability, and cost of land bank planning and development...1977. Airport land banking was studied and analyzed from several different perspectives, including legal, economic, and financial, and the results of this study are reported in this document. (Author)

  10. 14 CFR 221.52 - Airport to airport application, accessorial services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Airport to airport application, accessorial... Charges § 221.52 Airport to airport application, accessorial services. Tariffs shall specify whether or not the fares therein include services in addition to airport-to-airport transportation....

  11. 14 CFR 221.52 - Airport to airport application, accessorial services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Airport to airport application, accessorial... Charges § 221.52 Airport to airport application, accessorial services. Tariffs shall specify whether or not the fares therein include services in addition to airport-to-airport transportation....

  12. Supersonics--Airport Noise

    NASA Technical Reports Server (NTRS)

    Bridges, James

    2007-01-01

    At this, the first year-end meeting of the Fundamental Aeronautics Program, an overview of the Airport Noise discipline of the Supersonics Project leads the presentation of technical plans and achievements in this area of the Project. The overview starts by defining the Technical Challenges targeted by Airport Noise efforts, and the Approaches planned to meet these challenges. These are fleshed out in Elements, namely Prediction, Diagnostics, and Engineering, and broken down into Tasks. The Tasks level is where individual researchers' work is defined and from whence the technical presentations to follow this presentation come. This overview also presents the Milestones accomplished to date and to be completed in the next year. Finally, the NASA Research Announcement cooperative agreement activities are covered and tied to the Tasks and Milestones.

  13. GENERAL VIEW OF INTERIOR, MAIN READING ROOM, LOOKING SOUTHWEST AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW OF INTERIOR, MAIN READING ROOM, LOOKING SOUTHWEST AND SHOWING VIEW INTO REAR SECTION - Free Library of Philadelphia, Richmond Branch, 2987 Almond Street, Philadelphia, Philadelphia County, PA

  14. 8. Photocopy of circa 1892 construction photograph, courtesy of Reading ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of circa 1892 construction photograph, courtesy of Reading Company Archives - Philadelphia & Reading Railroad, Terminal Station, 1115-1141 Market Street, Philadelphia, Philadelphia County, PA

  15. 9. LOOKING NW FROM EAST BANK OF SCHUYLKILL RIVER. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. LOOKING NW FROM EAST BANK OF SCHUYLKILL RIVER. - Philadelphia & Reading Railroad, Schuylkill River Viaduct, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  16. 17. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST - Philadelphia & Reading Railroad, Schuylkill River Viaduct, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  17. 11. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. OVERVIEW FROM WEST BANK OF SCHUYLKILL RIVER, LOOKING EAST. - Philadelphia & Reading Railroad, Schuylkill River Viaduct, Spanning Schuylkill River, southeast of Roosevelt Boulevard Bridge, Philadelphia, Philadelphia County, PA

  18. 3. Photocopy of 1932 photograph showing another general view of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of 1932 photograph showing another general view of the mansion, looking northwest. Original photograph at the Philadelphia Museum of Art. - Strawberry Mansion, Philadelphia, Philadelphia County, PA

  19. WEST CORRIDOR (ORIGINALLY KNOWN AS LIBRARY OF CONGRESS CARD CATALOG) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST CORRIDOR (ORIGINALLY KNOWN AS LIBRARY OF CONGRESS CARD CATALOG) ON FIRST FLOOR, LOOKING EAST - Free Library of Philadelphia, Central Library, 1901 Vine Street, Philadelphia, Philadelphia County, PA

  20. 75 FR 39090 - Airport Privatization Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... Federal Aviation Administration Airport Privatization Pilot Program AGENCY: Federal Aviation... Gwinnett County Airport Briscoe Field (LZU), Lawrenceville, Georgia. SUMMARY: The Federal Aviation Administration (FAA) has completed its review of the Gwinnett County Airport Briscoe Field (LZU)...

  1. 78 FR 7476 - Airport Improvement Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... Federal Aviation Administration Airport Improvement Program AGENCY: Department of Transportation, Federal Aviation Administration. ACTION: Invitation to comment on draft FAA Order 5100-38, Airport Improvement...-38D, Airport Improvement Program Handbook. When finalized, this Order will replace Order...

  2. Intelligent building system for airport

    SciTech Connect

    Ancevic, M.

    1997-11-01

    The Munich airport uses a state-of-the-art intelligent building management system to control systems such as HVAC, runway lights, baggage handling, etc. Planning the new Munich II international airport provided a unique opportunity to use the latest state-of-the-art technical systems, while integrating their control through a single intelligent building management system. Opened in 1992, the airport is Germany`s second-largest airport after Frankfurt. The airport is staffed by 16,000 employees and can handle 17 million passengers a year. The sprawling site encompasses more than 120 buildings. The airport`s distributed control system is specifically designed to optimize the complex`s unique range of functions, while providing a high degree of comfort, convenience and safety for airport visitors. With the capacity to control 200,000 points, this system controls more than 112,000 points and integrates 13 major subsystems from nine different vendors. It provides convenient, accessible control of everything including the complex`s power plant, HVAC Control, the terminal`s people-moving functions, interior lighting controls, runway lights, baggage forwarding systems, elevators, and boarding bridges. The airport was named 1993 intelligent building of the year by the Intelligent Buildings Institute Foundation. Its building management system is a striking example of the degree to which a building complex`s functions can be integrated for greater operational control and efficiency.

  3. Proceedings of the Annual Symposium on Frequency Control (38th) Held in Philadelphia, Pennsylvania on 29 May - 1 June 1984

    DTIC Science & Technology

    1984-06-01

    the dominant aging 6 mechanism is adsorption or desorption. Similar scaling 4 - predicts that low-aging 2 GHz SAW delay lines might age 6 ppm/ year (based...2 (T)] (A. 4 ) (3) J. Rutman, "Characterization of Phase and Fre- [2= 377 quency Instabilities in Precision Frequency Sources: Fifteen Years of...cover, programs began more than ten years ago as a result of the electronics radiation shield, the header radiation Bendix’ independent research with

  4. The District: A History of the Philadelphia District, U.S. Army Corps of Engineers, 1866-1971

    DTIC Science & Technology

    1974-01-01

    above the water line. The island became a familiar, sentimental feature of the rhiladelphia scene through paintings and engravings of the eighteenth...from a painting by G. Stuart. American General and political leader in the Revolution. Quartermaster- General of the Revolutionary Army at different...Archives 114 .. ’ . ’ .... taken from the dyke in front of the six gun battery on Carpenter’s Island. Watercolor by Pierre Nicole, 1777. -Library of

  5. Single-Gender Public Education and Federal Policy: Implications of Gender-Based School Reforms in Philadelphia

    ERIC Educational Resources Information Center

    Friend, Jennifer

    2007-01-01

    Parochial and private schools in the United States have maintained opportunities for students to attend same-gender settings without interference from policies governing public education. The gender composition and curriculum of public schools, however, have been influenced by societal regulations and expectations that have often utilized…

  6. Proceedings of the Annual Meeting of the American Journalism Historians' Association (Philadelphia, Pennsylvania, October 3-5, 1991).

    ERIC Educational Resources Information Center

    American Journalism Historians' Association.

    The 24 papers in this collection discuss a variety of issues concerning the history of journalism in many countries. The papers are: "The East-Indian American Press" (Arthi Subramaniam); "The World's Oldest Magazine and Its Place in the Evolution of British Periodicals" (Sam G. Riley); "Donna Allen and the Women's…

  7. Proceedings of the Annual Symposium on Frequency Control (41st) Held in Philadelphia, Pennsylvania on 27-29 May 1987

    DTIC Science & Technology

    1987-05-29

    technique in ano 1 ~ Injection Locking Amplifier, in order to keep a givenphase difference between the oscillators. This feature?l l Is of special...Quartz Resonator ..................................................... 350 K.K. Kanazava and C.E. Reed, IBM Almden Rosearch Center A Novel Technique for...Relationship Between Resonator and Oscillator Noise, and Resonator Noise Measurement Techniques

  8. EnergyWorks Final Report: A Better Buildings Neighborhood Program in the Five-County Greater Philadelphia Region

    SciTech Connect

    Gajewski, Katherine

    2014-03-05

    This report covers the grant performance period of July 1, 2010-September 30, 2013 and discusses of the program design, outcomes and best practices as they relate to the following six areas: 1. Institutional Design and Business Model; 2. Program Design and Customer Experience; 3. Driving Demand; 4. Workforce Development; 5. Financing and Incentives; 6. Data and Evaluation.

  9. Proceedings of the Symposium on Frequency Control (36th Annual). 2-4 June 1982, Philadelphia, Pennsylvania,

    DTIC Science & Technology

    1982-01-01

    following long-lived isotopes (egOf Fe, Ni, Cr, a 3 nanose ~cond x-ray pulse is shown in and Ag) by a factor of 10 or more. Figijr- S. The ignit-ide of the...drying the crystal prior to measuring its near the plasma causes the electrode to frequency. One difficulty was that the be anodized. The oxide layer...frequency ad- justment, both liquid and RF anodization have the advantage over shadow masking techniques of providing uniform deposition of a protective oxide

  10. The District Role in Supporting College and Career Readiness for Students: Perspectives from Long Beach, Albuquerque, and Philadelphia

    ERIC Educational Resources Information Center

    Duffy, Helen; Darwin, Marlene

    2013-01-01

    Current federal policy and the broader national agenda focus on education as an integral element of a strong and competitive United States economy, and a well-educated workforce is essential to economic growth. To help build this workforce, state education agencies, local education agencies, and schools need to develop comprehensive approaches to…

  11. Frequency Control: Proceedings of the 40th Annual Symposium on held in Philadelphia, Pennsylvania on 28-30 May 1986

    DTIC Science & Technology

    1986-05-30

    Comparison of Various Alkali Gas Cell Atomic Frequency Standards ....................................................... 447 J.C. Camparo and R.P...investigated, including cesium beam material It also led to the recognition of the advantages to be machines and Rhubidium gas cells , as well as gas...with beam equipment--with the results that reference frequency to Hydrogen masers, cesium beam apparatus, alkali gas cells , an accuracy of better than

  12. The Nation's Report Card Mathematics 2013 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 8, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2013

    2013-01-01

    The National Assessment of Educational Progress (NAEP), in partnership with the National Assessment Governing Board and the Council of the Great City Schools (CGCS), created the Trial Urban District Assessment (TUDA) in 2002 to support the improvement of student achievement in the nation's large urban districts. NAEP TUDA results in mathematics…

  13. The Nation's Report Card Reading 2013 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 8, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2013

    2013-01-01

    The National Assessment of Educational Progress (NAEP), in partnership with the National Assessment Governing Board and the Council of the Great City Schools (CGCS), created the Trial Urban District Assessment (TUDA) in 2002 to support the improvement of student achievement in the nation's large urban districts. NAEP TUDA results in mathematics…

  14. The Nation's Report Card Reading 2013 Trial Urban District Snapshot Report. School District of Philadelphia. Grade 4, Public Schools

    ERIC Educational Resources Information Center

    National Center for Education Statistics, 2013

    2013-01-01

    The National Assessment of Educational Progress (NAEP), in partnership with the National Assessment Governing Board and the Council of the Great City Schools (CGCS), created the Trial Urban District Assessment (TUDA) in 2002 to support the improvement of student achievement in the nation's large urban districts. NAEP TUDA results in mathematics…

  15. Existing Whole-House Solutions Case Study: 56th and Walnut: A Philly Gut Rehab Development, Philadelphia, Pennsylvania

    SciTech Connect

    2013-11-01

    Load-bearing brick-masonry multifamily buildings are prevalent in urban areas across much of the Northeast and mid-Atlantic. In most instances, these buildings are uninsulated unless they have been renovated within the past two decades. Affordable housing capital budgets typically limit what can be spent and energy improvements often take a back seat to basic capital improvements such as interior finish upgrades and basic repairs. The Consortium for Advanced Residential Buildings (CARB) is researching cost-effective solution packages for significant energy efficiency and indoor air-quality improvements in these urban buildings.

  16. Proceedings of the Annual Symposium on Frequency Control (37th). 1-3 June 1983, Marriott Hotel, Philadelphia, Pennsylvania.

    DTIC Science & Technology

    1983-06-03

    Multiple Frequency Microwave Source. AD-P002 459 Synchronization and Tracking with Synchronous Oscillators. AD-P002 460 Frequency (Standard) Combiner...Behavior in the System H2 0-NaOH- Si02 and its Relationship to the Hydrothermal Growth of Quartz. AD-P002 469 Standard Characterization Methods for the...COMPONENT PART NOTICE (CON’T) AD#: TITLE: AD-P002 491 A New Frequency for Piezoelectric Resonator Measurement. AD-P002 492 Measuring Method of Equivalent

  17. LINKING AIR TOXIC CONCENTRATIONS FROM CMAQ TO THE HAPEM5 EXPOSURE MODEL AT NEIGHORHOOD SCALES FOR THE PHILADELPHIA AREA

    EPA Science Inventory

    This paper provides a preliminary demonstration of the EPA neighborhood scale modeling paradigm for air toxics by linking concentration from the Community Multi-scale Air Quality (CMAQ) modeling system to the fifth version of the Hazardous Pollutant Exposure Model (HAPEM5). For ...

  18. Acute myelomonocytic leukemia with inv(16)(p13q22) complicating Philadelphia chromosome positive chronic myeloid leukemia.

    PubMed

    Heim, S; Christensen, B E; Fioretos, T; Sørensen, A G; Pedersen, N T

    1992-03-01

    The reciprocal translocation (9;22)(q34;q11) is highly characteristic of chronic myeloid leukemia (CML) and the pericentric inversion inv(16)(p13q22) is almost only found in acute nonlymphocytic leukemia of the myelomonocytic subtype (ANLL M4). Only twice before have an inv(16) and a t(9;22) been found in the same cells, and both times the patients seemed to have de novo ANLL M4. We describe the case of a 21-year-old man who in July 1986 presented with a clinically and hematologically classic chronic phase CML. Treatment with busulfan led to no improvement; instead in September 1986 he developed blast crisis with ANLL M4Eo morphology. He was now cytogenetically examined and the karyotype 45,X,-Y,t(9;22)(q34;q11),inv(16)(p13q22) was found. Southern blot analysis of the bone marrow DNA sampled at this time revealed a standard rearrangement in the 3' end of the M-bcr. Intensive cytostatic treatment caused cytopenia followed by complete hematologic, clinical, and cytogenetic reversal to chronic phase CML, so that in January 1987 the bone marrow karyotype was 46,XY,t(9;22)(q34;q11). Persistent splenomegaly was treated with splenectomy, and a chloroma of the skin was removed by irradiation. In March 1987 he received an allogeneic bone marrow transplant. Since then his only medical problem has been mild graft-versus-host disease; he is well and is working full time as a blacksmith.

  19. A Snapshot of OST Programs in Philadelphia: An Evaluation of Eleven 21st Century Community Learning Center Grantees

    ERIC Educational Resources Information Center

    Gao, Jian; Hallar, Brittan; Hartmann, Tracey A.

    2014-01-01

    This report examines the 21st Century Community Learning Center (CCLC) programs evaluated by Research for Action (RFA) and presents an aggregate analysis of key findings to inform broader discussions about OST programs. The report addresses the following questions: (1) Who participated in the 21st CCLC programs and how frequently did they…

  20. Teaching of Psychology: Ideas and Innovations. Proceedings of the Third Annual Conference (Philadelphia, Pennsylvania, March 9-11, 1989).

    ERIC Educational Resources Information Center

    Levine, Judith R., Ed.; Feist, Stanley C., Ed.

    This conference proceedings includes the text of 15 of the 27 presentations made at the third annual Conference on Undergraduate Teaching of Psychology. In addition to a conference program, the proceedings includes the following papers: (1) "Multiethnic, Crosscultural Illustrations for Psychology Courses," by Judith Gray; (2) "A Computerized…