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Sample records for al ieee trans

  1. IEEE Smart Grid Series of Standards IEEE 2030 (Interoperability) and IEEE 1547 (Interconnection) Status: Preprint

    SciTech Connect

    Basso, T.; DeBlasio, R.

    2012-04-01

    The IEEE American National Standards smart grid publications and standards development projects IEEE 2030, which addresses smart grid interoperability, and IEEE 1547TM, which addresses distributed resources interconnection with the grid, have made substantial progress since 2009. The IEEE 2030TM and 1547 standards series focus on systems-level aspects and cover many of the technical integration issues involved in a mature smart grid. The status and highlights of these two IEEE series of standards, which are sponsored by IEEE Standards Coordinating Committee 21 (SCC21), are provided in this paper.

  2. IEEE standards worldwide

    SciTech Connect

    Hammons, T.J. )

    1995-01-01

    This article presents North American views on the development and use of internationally acceptable standards through strengthened ties with global standards organizations. The key ingredient to enhance the international reputation of IEEE standards is, without doubt, greater participation of members around the world. Standards that will really have force are those that are recognized as preeminent and that are sought after by organizations worldwide. it will be necessary to develop enhanced liaisons with standards organizations around the world, such as the IEC. These are some of the issues that will be addressed by panelists representing standards organizations and users from North America, United States, Canada, and Mexico. Also discussed is the importance of standards in the NAFTA and GATT agreements on trade.

  3. IEEE Conference Publications in Libraries.

    ERIC Educational Resources Information Center

    Johnson, Karl E.

    1984-01-01

    Conclusions of surveys (63 libraries, OCLC database, University of Rhode Island users) assessing handling of Institute of Electrical and Electronics Engineers (IEEE) conference publications indicate that most libraries fully catalog these publications using LC cataloging, and library patrons frequently require series access to publications. Eight…

  4. The CpAL system regulates changes of the trans-epithelial resistance of human enterocytes during Clostridium perfringens type C infection.

    PubMed

    Nava, Porfirio; Vidal, Jorge E

    2016-06-01

    Clostridium perfringens type C strains produce severe disease in humans and animals including enterotoxaemia and hemorrhagic diarrhea. Type C disease is mediated by production of toxins that damage the site of infection inducing loss of bloody fluids. Production of type C toxins, such as CPA, PFO, and, CPB is regulated by the C. perfringens Agr-like (CpAL) quorum sensing (QS) system. The CpAL system is also required to recapitulate, in vivo, intestinal signs of C. perfringens type C-induced disease, including hemorrhagic diarrhea and accumulation of fluids. The intestinal epithelium forms a physical barrier, made up of a series of intercellular junctions including tight junctions (TJs), adherens junctions (AJs) and desmosomes (DMs). This selective barrier regulates important physiological processes, including paracellular movement of ions and solutes, which, if altered, results in loss of fluids into the intestinal lumen. In this work, the effects of C. perfringens infection on the barrier function of intestinal epithelial cells was evaluated by measuring trans-epithelial resistance (TEER). Our studies demonstrate that infection of human enterocytes with C. perfringens type C strain CN3685 induced a significant drop on TEER. Changes in TEER were mediated by the CpAL system as a CN3685ΔagrB mutant did not induce such a drop. Physical contact between bacteria and enterocytes produced more pronounced changes in TEER and this phenomenon appeared also to be mediated by the CpAL system. Finally, immunofluorescence studies demonstrate that C. perfringens type C infection redistribute TJs protein occludin, and Claudin-3, and DMs protein desmoglein-2, but did not affect the AJs protein E-cadherin.

  5. Electronic structure calculations of delafossite Cu-based transparent conducting oxides CuMO2 (M =B,Al,Ga,In) by quasiparticle self-consistent GW approximation and Tran-Blaha's modified Becke-Johnson exchange potential

    NASA Astrophysics Data System (ADS)

    Thatribud, Abdulmutta; Pengpan, Teparksorn

    2014-09-01

    In this work, band gaps of the delafossite Cu-based transparent conducting oxides CuMO2 (M =B,Al,Ga,In) are calculated by density functional theory (DFT) implemented with many-body perturbation theory (MBPT) based on quasiparticle self-consistent GW approximation (QPscGW) and with Tran-Blaha's modified Becke-Johnson functional (DFT-TB09). Their band gaps are explicitly improved from DFT within local density approximation (LDA). Their optical absorption spectra are also calculated by solving Bethe-Salpeter equation (BSE) that includes the electron-hole correlation effect; they show strong excitonic peaks.

  6. Risk Management Supplement to IEEE-15288.1

    DTIC Science & Technology

    2015-05-15

    AND MISSILE SYSTEMS CENTER TAILORING RISK MANAGEMENT SUPPLEMENT TO IEEE -15288.1 APPROVED FOR PUBLIC RELEASE...IEC- IEEE -15288: 2015, SYSTEMS AND SOFTWARE ENGINEERING — SYSTEM LIFE CYCLE PROCESSES...1 2.2. IEEE -15288.1: 2015, STANDARD FOR APPLICATION OF SYSTEMS ENGINEERING ON DEFENSE PROGRAMS

  7. Defining the IEEE-854 floating-point standard in PVS

    NASA Technical Reports Server (NTRS)

    Miner, Paul S.

    1995-01-01

    A significant portion of the ANSI/IEEE-854 Standard for Radix-Independent Floating-Point Arithmetic is defined in PVS (Prototype Verification System). Since IEEE-854 is a generalization of the ANSI/IEEE-754 Standard for Binary Floating-Point Arithmetic, the definition of IEEE-854 in PVS also formally defines much of IEEE-754. This collection of PVS theories provides a basis for machine checked verification of floating-point systems. This formal definition illustrates that formal specification techniques are sufficiently advanced that is is reasonable to consider their use in the development of future standards.

  8. Trans-Friendly Preschool

    ERIC Educational Resources Information Center

    Dykstra, Laurel A.

    2005-01-01

    Transgender kids and kids from trans families attend preschool and kindergarten. For the safety, comfort, and optimum learning of these students, trans-positive early childhood education environments are necessary. Through simple changes to existing curricula and equipment, teachers, parents, and administrators can create a trans-positive setting…

  9. Specialty Engineering Supplement to IEEE-15288.1

    DTIC Science & Technology

    2015-05-15

    MISSILE SYSTEMS CENTER TAILORING SPECIALTY ENGINEERING SUPPLEMENT TO IEEE -15288.1 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION...IS UNLIMITED 1 Tailoring of IEEE 15288.1: Specialty Engineering Supplement. 1. Intent of this Tailoring Document This tailoring document is...historically deemed valuable to mission assurance/success of high-reliability space systems. This tailoring document supplements IEEE 15288.1-2015 Annex E

  10. IEEE 1547 Standards Advancing Grid Modernization

    SciTech Connect

    Basso, Thomas; Chakraborty, Sudipta; Hoke, Andy; Coddington, Michael

    2015-06-14

    Technology advances including development of advanced distributed energy resources (DER) and grid-integrated operations and controls functionalities have surpassed the requirements in current standards and codes for DER interconnection with the distribution grid. The full revision of IEEE Standards 1547 (requirements for DER-grid interconnection and interoperability) and 1547.1 (test procedures for conformance to 1547) are establishing requirements and best practices for state-of-the-art DER including variable renewable energy sources. The revised standards will also address challenges associated with interoperability and transmission-level effects, in addition to strictly addressing the distribution grid needs. This paper provides the status and future direction of the ongoing development focus for the 1547 standards.

  11. Sine-Fitting Software for IEEE Standard 1057

    SciTech Connect

    Blair, Jerome

    1999-05-01

    Software application that performs the calculations related to the sine-fit tests of IEEE Standard 1057/94. Example outputs and explainations of these outputs to determine the important characteristics of the device under test. This application performs the calculations related to sine-fit tests and uses 4-parameter sine fit from IEEE Standard 1057-1994.

  12. IEEE Standard Dictionary of Electrical and Electronics Terms.

    ERIC Educational Resources Information Center

    Institute of Electrical and Electronics Engineers, Inc., New York, NY.

    This dictionary, prepared by the Institute of Electrical and Electronics Engineers, Inc. (IEEE), defines 13,000 technical words from every area of electrical and electronics engineering. The dictionary contains hundreds of new terms as well as revisions of earlier ones. Each definition is an official standard of IEEE. The definitions are arranged…

  13. Trans Fatty Acids

    NASA Astrophysics Data System (ADS)

    Doyle, Ellin

    1997-09-01

    Fats and their various fatty acid components seem to be a perennial concern of nutritionists and persons concerned with healthful diets. Advice on the consumption of saturated, polyunsaturated, monounsaturated, and total fat bombards us from magazines and newspapers. One of the newer players in this field is the group of trans fatty acids found predominantly in partially hydrogenated fats such as margarines and cooking fats. The controversy concerning dietary trans fatty acids was recently addressed in an American Heart Association (AHA) science advisory (1) and in a position paper from the American Society of Clinical Nutrition/American Institute of Nutrition (ASCN/AIN) (2). Both reports emphasize that the best preventive strategy for reducing risk for cardiovascular disease and some types of cancer is a reduction in total and saturated fats in the diet, but a reduction in the intake of trans fatty acids was also recommended. Although the actual health effects of trans fatty acids remain uncertain, experimental evidence indicates that consumption of trans fatty acids adversely affects serum lipid levels. Since elevated levels of serum cholesterol and triacylglycerols are associated with increased risk of cardiovascular disease, it follows that intake of trans fatty acids should be minimized.

  14. Delay Analysis of GTS Bridging between IEEE 802.15.4 and IEEE 802.11 Networks for Healthcare Applications.

    PubMed

    Misić, Jelena; Sherman Shen, Xuemin

    2009-01-01

    We consider interconnection of IEEE 802.15.4 beacon-enabled network cluster with IEEE 802.11b network. This scenario is important in healthcare applications where IEEE 802.15.4 nodes comprise patient's body area network (BAN) and are involved in sensing some health-related data. BAN nodes have very short communication range in order to avoid harming patient's health and save energy. Sensed data needs to be transmitted to an access point in the ward room using wireless technology with higher transmission range and rate such as IEEE 802.11b. We model the interconnected network where IEEE 802.15.4-based BAN operates in guaranteed time slot (GTS) mode, and IEEE 802.11b part of the bridge conveys GTS superframe to the 802.11b access point. We then analyze the network delays. Performance analysis is performed using EKG traffic from continuous telemetry, and we discuss the delays of communication due the increasing number of patients.

  15. IEEE 342 Node Low Voltage Networked Test System

    SciTech Connect

    Schneider, Kevin P.; Phanivong, Phillippe K.; Lacroix, Jean-Sebastian

    2014-07-31

    The IEEE Distribution Test Feeders provide a benchmark for new algorithms to the distribution analyses community. The low voltage network test feeder represents a moderate size urban system that is unbalanced and highly networked. This is the first distribution test feeder developed by the IEEE that contains unbalanced networked components. The 342 node Low Voltage Networked Test System includes many elements that may be found in a networked system: multiple 13.2kV primary feeders, network protectors, a 120/208V grid network, and multiple 277/480V spot networks. This paper presents a brief review of the history of low voltage networks and how they evolved into the modern systems. This paper will then present a description of the 342 Node IEEE Low Voltage Network Test System and power flow results.

  16. Low Trans Hydrogenation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Although hydrogenation has been the technology of choice for fat formulation for many years recent concerns over the health and nutrition of trans fatty acids have had a profound effect on the edible oil industry. Since Jan. 1, 2006, TFA has been required on nutrition labels along with saturated an...

  17. Facts about trans fats

    MedlinePlus

    ... gov/pubmed/24327023 . US Department of Health and Human Services, Food and Drug Administration. Trans fat . Updated June 15, 2015. www.fda.gov/food/populartopics/ucm292278.htm . Accessed May 5, 2015. US Department of Health and Human Services and US Department of Agriculture. 2015 - 2020 ...

  18. IEEE 1547 Series of Standards: Interconnection Issues; Preprint

    SciTech Connect

    Basso, T.; DeBlasio, R.

    2003-09-01

    IEEE 1547TM 2003 Standard for Interconnecting Distributed Resources With Electric Power Systems is the first in the 1547 series of planned interconnection standards. Major issues and a wealth of constructive dialogue arose during 1547 development. There was also a perceived increased vitality in updating complementary IEEE standards and developing additional standards to accommodate modern electrical and electronics systems and improved grid communications and operations. Power engineers and other stakeholders looking to the future are poised to incorporate 1547 into their knowledge base to help transform our nation's aging distribution systems while alleviating some of the burden on existing transmission systems.

  19. System Behavior Specification Using IEEE Std 1175.4

    DTIC Science & Technology

    2010-04-27

    22nd Annual Systems & Software Technology Conference S stem Beha ior Specification1 7 y v Using IEEE Std 1175.4 e v i e w 5 2 8 1 2 R 27 April...DATE 27 APR 2010 2. REPORT TYPE 3. DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE System Behavior Specification Using IEEE Std ...RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std

  20. Fatty acids - trans fatty acids

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The data supporting a negative effect of dietary trans fatty acids on cardiovascular disease risk is consistent. The primary dietary sources of trans fatty acids include partially hydrogenated fat and rudiment fat. The adverse effect of trans fatty acids on plasma lipoprotein profiles is consisten...

  1. Eleanor McElwee and the Formation of IEEE PCS

    ERIC Educational Resources Information Center

    Malone, Edward A.

    2015-01-01

    This article examines the historical professional project that created the Institute of Radio Engineers' Professional Group on Engineering Writing an Speech (IRE PGEWS)--now called the Institute of Electrical and Electronics Engineers' Professional Communication Society (IEEE PCS)--and recounts the group's early history in detail. It also traces…

  2. Radio Frequency Fingerprinting Techniques Through Preamble Modification in IEEE 802.11B

    DTIC Science & Technology

    2014-06-30

    David Bull, and Joseph McGeehan. “A Comparison of the HIPERLAN/2 and IEEE 802.11a Wireless LAN Standards”, Communications Magazine , IEEE , vol. 40, no...RADIO FREQUENCY FINGERPRINTING TECHNIQUES THROUGH PREAMBLE MODIFICATION IN IEEE 802.11B THESIS Nicholas J. Kulesza, Captain, USAF AFIT–ENG–T–14–J–8...MODIFICATION IN IEEE 802.11B THESIS Presented to the Faculty Department of Electrical and Computer Engineering Graduate School of Engineering and Management

  3. An IEEE 1451.1 Architecture for ISHM Applications

    NASA Technical Reports Server (NTRS)

    Morris, Jon A.; Turowski, Mark; Schmalzel, John L.; Figueroa, Jorge F.

    2007-01-01

    The IEEE 1451.1 Standard for a Smart Transducer Interface defines a common network information model for connecting and managing smart elements in control and data acquisition networks using network-capable application processors (NCAPs). The Standard is a network-neutral design model that is easily ported across operating systems and physical networks for implementing complex acquisition and control applications by simply plugging in the appropriate network level drivers. To simplify configuration and tracking of transducer and actuator details, the family of 1451 standards defines a Transducer Electronic Data Sheet (TEDS) that is associated with each physical element. The TEDS contains all of the pertinent information about the physical operations of a transducer (such as operating regions, calibration tables, and manufacturer information), which the NCAP uses to configure the system to support a specific transducer. The Integrated Systems Health Management (ISHM) group at NASA's John C. Stennis Space Center (SSC) has been developing an ISHM architecture that utilizes IEEE 1451.1 as the primary configuration and data acquisition mechanism for managing and collecting information from a network of distributed intelligent sensing elements. This work has involved collaboration with other NASA centers, universities and aerospace industries to develop IEEE 1451.1 compliant sensors and interfaces tailored to support health assessment of complex systems. This paper and presentation describe the development and implementation of an interface for the configuration, management and communication of data, information and knowledge generated by a distributed system of IEEE 1451.1 intelligent elements monitoring a rocket engine test system. In this context, an intelligent element is defined as one incorporating support for the IEEE 1451.x standards and additional ISHM functions. Our implementation supports real-time collection of both measurement data (raw ADC counts and

  4. IEEE P1547 Series of Standards for Interconnection: Preprint

    SciTech Connect

    Basso, T. S.; DeBlasio, R.

    2003-05-01

    The IEEE P1547 Standard For Interconnecting Distributed Resources With Electric Power Systems is the first in the P1547 series of planned interconnection standards, and additional standards are needed. There are major issues and obstacles to an orderly transition to the use and integration of distributed power resources with electric power systems (grid or utility grid). The lack of uniform national interconnection standards and tests for interconnection operation and certification-as well as the lack of uniform national building, electrical, and safety codes-is understood, and resolving this needs reasonable lead time to develop and promulgate consensus. The P1547 standard is a benchmark milestone for the IEEE standards consensus process and successfully demonstrates a model for ongoing success in the development of further national standards and for moving forward in modernizing our nation's electric power system.

  5. Computer aided coordination of line protection schemes IEEE committee report

    SciTech Connect

    Postforoosh, J.M.; Akamine, J.; Banerjee, H.N.; Cornelison, J.R.; Enns, M.K.; Grier, S.E.; Hass, R.W.; Hasenwinkle, I.O.; Johnson, R.W.; Mozina, C.J.; Ramaswami, R.; Smith, H.S.; Taylor, R.P.; Turley, J.R.; Zipp, J.A.

    1991-04-01

    IEEE PSRC working group on Computer Aided Coordination of Line Protection Schemes was established in 1985 to investigate the application of computers to the task of setting and verifying the setting of line protective devices. This report provides the findings of the working group regarding functional requirements of the data base, software, and hardware for this system as well as the methods of presenting the results to the protection engineer.

  6. Performance of IEEE 1588 in Large-Scale Networks

    DTIC Science & Technology

    2010-11-01

    commercially available Syn1588 network cards from Oregano Systems. They not only feature an IEEE 1588 hardware timestamper, but also a 1 PPS output...of the measurements, which are done per default once a second, can be removed considering the short-term stability of the oscillator. As the Oregano ...PTTI) Meeting 76 ACKNOWLEDGMENTS The authors wish to thank Julien Ridoux, the University of Melbourne, Oregano Systems, and Meinberg for

  7. [CONTENT OF TRANS FATTY ACIDS IN FOOD PRODUCTS IN SPAIN].

    PubMed

    Robledo de Dios, Teresa; Dal Re Saavedra, M Ángeles; Villar Villalba, Carmen; Pérez-Farinós, Napoleón

    2015-09-01

    Introducción: los ácidos grasos trans están asociados con problemas de salud, como enfermedad coronaria o diabetes. Objetivos: conocer la cantidad de ácidos grasos trans en los alimentos en España, y el porcentaje que representan con respecto al total de los ácidos grasos. Métodos: se estudió el contenido en ácidos grasos de 443 alimentos adquiridos en España en el año 2010, y clasificados en grupos. Determinación analítica de grasas en los productos mediante cromatografía de gases. Se calcularon estimadores de tendencia central y dispersión de la cantidad de ácidos grasos trans en cada grupo (g de ácidos grasos trans/100 g de producto). Se calculó el porcentaje de ácidos grasos trans con respecto a la grasa total en cada grupo. Resultados: los productos se agruparon en 42 grupos. En todos, salvo uno, la mediana de ácidos grasos trans fue inferior a 0,55 g/100 g de producto. El 83 % de los grupos tienen menos del 2 % de ácidos grasos trans con respecto a las grasas totales, y el 71 %, menos del 1 %. Discusión: el contenido de AGT en los alimentos en España es bajo y no representa actualmente un problema de salud pública.

  8. IEEE Nuclear and Space Radiation Effects Conference: Notes on the Early Conferences

    NASA Technical Reports Server (NTRS)

    Pellish, Jonathan A.; Galloway, Kenneth F.

    2013-01-01

    This paper gathers the remembrances of several key contributors who participated in the earliest Institute of Electrical and Electronics Engineers (IEEE) Nuclear and Space Radiation Effects Conferences (NSREC).

  9. Benefits of IEEE-754 features in modern symmetric tridiagonaleigensolvers

    SciTech Connect

    Marques, Osni; Riedy, Jason E.; Vomel, Christof

    2006-03-12

    Bisection is one of the most common methods used to compute the eigenvalues of symmetric tridiagonal matrices. Bisection relies on the Sturm count: For a given shift a, the number of negative pivots in the factorization T - {sigma}I = LDL{sup T} equals the number of eigenvalues of T that are smaller than a. In IEEE-754 arithmetic, the value oo permits the computation to continue past a zero pivot, producing a correct Sturm count when T is unreduced. Demmel and Li showed that using oo rather than testing for zero pivots within the loop could significantly improve performance on certain architectures. When eigenvalues are to be computed to high relative accuracy, it is often preferable to work with LDL{sup T} factorizations instead of the original tridiagonal T. One important example is the MRRR algorithm. When bisection is applied to the factored matrix, the Sturm count is computed from LDL{sup T} which makes differential stationary and progressive qds algorithms the methods of choice. While it seems trivial to replace T by LDL{sup T}, in reality these algorithms are more complicated: In IEEE-754 arithmetic, a zero pivot produces an overflow followed by an invalid exception (NaN, or 'Not a Number') that renders the Sturm count incorrect. We present alternative, safe formulations that are guaranteed to produce the correct result. Benchmarking these algorithms on a variety of platforms shows that the original formulation without tests is always faster provided that no exception occurs. The transforms see speed-ups of up to 2.6x over the careful formulations. Tests on industrial matrices show that encountering exceptions in practice is rare. This leads to the following design: First, compute the Sturm count by the fast but unsafe algorithm. Then, if an exception occurs, recompute the count by a safe, slower alternative. The new Sturm count algorithms improve the speed of bisection by up to 2x on our test matrices. Furthermore, unlike the traditional tiny

  10. IEEE 802.11 Wireless LAN Security White Paper

    SciTech Connect

    King, J

    2001-10-22

    Given the increased productivity and growing popularity of wireless communications in general, and wireless data communications in particular, this paper outlines the protocols, security implications, and architectures of IEEE Std. 802.11-1999 wireless LANs (WLANs) and makes recommendations regarding a phased implementation of WLANs at LLNL. This project is driven by the need for convenient and secure access to the Internet for Laboratory visitors and to the internal network for Laboratory employees. A solid architecture designed with a priority on security will allow LLNL to offer network access in areas where it is traditionally hard to deploy wired networks. It will also enable such services as wireless access for inventory control and convenient network access for conference rooms around LLNL. Wireless network access has the potential to increase productivity by enabling instant access to information.

  11. Review of the IEEE Standard for Computerized Operating Procedure Systems

    SciTech Connect

    O'Hara, J.; Higgins, J.

    2010-02-26

    Increasingly nuclear power plant procedures, such as emergency operating procedures, are being presented in computer form with functionality to support operator use and management of the procedures. The U.S. Nuclear Regulatory Commission (NRC) currently has guidance for the review of computer-based procedures (CBPs); however, there remain CBP functions and human performance issues for which up-to-date guidance is lacking. The Institute of Electrical and Electronics Engineers (IEEE) has initiated a standard development effort to address the human factors engineering (HFE) aspects of CBP systems. When completed, it may provide guidance to supplement the NRC staff's review criteria. The purpose of our study was to evaluate the suitability of the IEEE Standard for use in the NRC's HFE safety reviews of CBP systems and to ensure that the guidance meets the NRC's standard for scientific and engineering rigor used in its own guidance development efforts. We established the following criteria with which to evaluate the Standard: (1) it should meet an existing need of NRC reviewers, (2) it should be based in sound HFE principles, (3) it should be thoroughly peer-reviewed, and (4) it should address CBP-related human performance issues identified in the literature. This report describes the methodology we used to evaluate each criterion. Our evaluation concluded that the Standard generally does meet these criteria, however several areas were identified for which additional clarifications are needed. Thus consideration of the Standard's use by the NRC is supported. The standard evaluation methodology developed in this study can be generally applied to the review of other HFE standards being considered for possible use or endorsement by the NRC.

  12. Letter to the editor: healthy alternatives to trans fats.

    PubMed

    Destaillats, Frédéric; Moulin, Julie; Bezelgues, Jean-Baptiste

    2007-04-27

    Consumption of trans fats is associated with an increase of cardiovascular disease (CVD) risk. To comply with regulatory policies and public health authorities recommendations, trans fats should be replaced in food products. The study by Sundram et al. (Nutrition & Metabolism 2007, 4:3) reporting the effect on CVD risk factors of interesterified fat (IE) and partially hydrogenated soybean oil (PHSO) compared to palm olein (POL) has been critically analyzed. The study design and in particular the composition of the tested fats was not suitable to properly answer the question raised regarding the effect of alternative ingredients to trans fats on plasma lipids. The observed effects are divergent with predicted data derived from the literature model consolidated using the individual results of 60 randomized clinical trials. The results of the study published by Sundram and co-workers have to be considered with awareness.

  13. Comparison Of Several Methods Of Implementing A Fiber Optic IEEE 802.3 Ethernet

    NASA Astrophysics Data System (ADS)

    Thompson, Geoffrey O.

    1987-01-01

    Several different methods of implementing a fiber optic version of IEEE 802.3 10BASE LANs have been proposed as a candidate for standardization by IEEE. There have been extensive discussions as to the relative merits and features of the several systems. This paper will discuss the merits of each for this particular application on a comparative basis.

  14. trans-1,2-Dichloroethylene

    Integrated Risk Information System (IRIS)

    trans - 1,2 - Dichloroethylene ; CASRN 156 - 60 - 5 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for No

  15. IEEE 802.11ah: A Technology to Face the IoT Challenge

    PubMed Central

    Baños-Gonzalez, Victor; Afaqui, M. Shahwaiz; Lopez-Aguilera, Elena; Garcia-Villegas, Eduard

    2016-01-01

    Since the conception of the Internet of things (IoT), a large number of promising applications and technologies have been developed, which will change different aspects in our daily life. This paper explores the key characteristics of the forthcoming IEEE 802.11ah specification. This future IEEE 802.11 standard aims to amend the IEEE 802.11 legacy specification to support IoT requirements. We present a thorough evaluation of the foregoing amendment in comparison to the most notable IEEE 802.11 standards. In addition, we expose the capabilities of future IEEE 802.11ah in supporting different IoT applications. Also, we provide a brief overview of the technology contenders that are competing to cover the IoT communications framework. Numerical results are presented showing how the future IEEE 802.11ah specification offers the features required by IoT communications, thus putting forward IEEE 802.11ah as a technology to cater the needs of the Internet of Things paradigm. PMID:27879688

  16. IEEE 802.11ah: A Technology to Face the IoT Challenge.

    PubMed

    Baños-Gonzalez, Victor; Afaqui, M Shahwaiz; Lopez-Aguilera, Elena; Garcia-Villegas, Eduard

    2016-11-22

    Since the conception of the Internet of things (IoT), a large number of promising applications and technologies have been developed, which will change different aspects in our daily life. This paper explores the key characteristics of the forthcoming IEEE 802.11ah specification. This future IEEE 802.11 standard aims to amend the IEEE 802.11 legacy specification to support IoT requirements. We present a thorough evaluation of the foregoing amendment in comparison to the most notable IEEE 802.11 standards. In addition, we expose the capabilities of future IEEE 802.11ah in supporting different IoT applications. Also, we provide a brief overview of the technology contenders that are competing to cover the IoT communications framework. Numerical results are presented showing how the future IEEE 802.11ah specification offers the features required by IoT communications, thus putting forward IEEE 802.11ah as a technology to cater the needs of the Internet of Things paradigm.

  17. Al2O3 nanocrystals embedded in amorphous Lu2O3 high-k gate dielectric for floating gate memory application

    NASA Astrophysics Data System (ADS)

    Yuan, C. L.; Chan, M. Y.; Lee, P. S.; Darmawan, P.; Setiawan, Y.

    2007-04-01

    The integration of nanoparticles has high potential in technological applications and opens up possibilities of the development of new devices. Compared to the conventional floating gate memory, a structure containing nanocrystals embedded in dielectrics shows high potential to produce a memory with high endurance, low operating voltage, fast write-erase speeds and better immunity to soft errors [S. Tiwari, F. Rana, H. Hanafi et al. 1996 Appl.Phys. Lett. 68, 1377]. A significant improvement on data retention [J. J. Lee, X. Wang et al. 2003 Proceedings of the VLSI Technol. Symposium, p33] can be observed when discrete nanodots are used instead of continuous floating gate as charge storage nodes because local defect related leakage can be reduced efficiently. Furthermore, using a high-k dielectric in place of the conventional SiO2 based dielectric, nanodots flash memory is able to achieve significantly improved programming efficiency and data retention [A. Thean and J. -P. Leburton, 2002 IEEE Potentials 21, 35; D. W. Kim, T. Kim and S. K. Banerjee, 2003 IEEE Trans. Electron Devices 50, 1823]. We have recently successfully developed a method to produce nanodots embedded in high-k gate dielectrics [C. L. Yuan, P. Darmawan, Y. Setiawan and P. S. Lee, 2006 Electrochemical and Solid-State Letters 9, F53; C. L. Yuan, P. Darmawan, Y. Setiawan and P. S. Lee, 2006 Europhys. Lett. 74, 177]. In this paper, we fabricated the memory structure of Al2O3 nanocrystals embedded in amorphous Lu2O3 high k dielectric using pulsed laser ablation. The mean size and density of the Al2O3 nanocrystals are estimated to be about 5 nm and 7x1011 cm-2, respectively. Good electrical performances in terms of large memory window and good data retention were observed. Our preparation method is simple, fast and economical.

  18. Performance Analysis of IEEE 802.11e (EDCF) and IEEE 802.11(DCF) WLAN Incorporating Different Physical Layer Standards

    NASA Astrophysics Data System (ADS)

    Sharma, V.; Singh, H.; Malhotra, J.

    2012-12-01

    Medium access coordination function basically implements the distributed coordination function (DCF) which provides support to best effort services but limited to QoS services. Subsequently, a new standard, namely enhanced distributed channel access (EDCA) is reported. The IEEE 802.11e (EDCA) defines MAC procedures to support QoS requirements which specifies distributed contention based access scheme to access the shared wireless media. This paper evaluates the performance of EDCA based IEEE 802.11 WLAN for various access categories (ACs) using OPNET™ Modeller 14.5. Further, the computed results are compared with DCF protocols in terms of QoS parameters. Furthermore, the simulative observation is reported at data rate of 54 Mbps using different physical layer protocols such as IEEE 802.11a/b/g to stumble on the best one to be implemented with EDCF to achieve improved QoS.

  19. Analysis of Adaptive Control Scheme in IEEE 802.11 and IEEE 802.11e Wireless LANs

    NASA Astrophysics Data System (ADS)

    Lee, Bih-Hwang; Lai, Hui-Cheng

    In order to achieve the prioritized quality of service (QoS) guarantee, the IEEE 802.11e EDCAF (the enhanced distributed channel access function) provides the distinguished services by configuring the different QoS parameters to different access categories (ACs). An admission control scheme is needed to maximize the utilization of wireless channel. Most of papers study throughput improvement by solving the complicated multidimensional Markov-chain model. In this paper, we introduce a back-off model to study the transmission probability of the different arbitration interframe space number (AIFSN) and the minimum contention window size (CWmin). We propose an adaptive control scheme (ACS) to dynamically update AIFSN and CWmin based on the periodical monitoring of current channel status and QoS requirements to achieve the specific service differentiation at access points (AP). This paper provides an effective tuning mechanism for improving QoS in WLAN. Analytical and simulation results show that the proposed scheme outperforms the basic EDCAF in terms of throughput and service differentiation especially at high collision rate.

  20. Trans World Tidal Gravity Profile.

    DTIC Science & Technology

    1984-12-31

    America Curitiba (BraziZ) This station, situated at the Universidade Federal do Parana, in the Instituto de Ciencias Geod6sicas under Professor C...SUL COMPOSANTE VEPTICALE ERESIL 29 40 17S 53 49 22W H 700M P 2M 0 330KM DEPOTS SEDIMENTAIRES SUk BASALTE DEPT* DE INGENIERIA RURAL-UNIV. FED. DE SANTA...PRECAMBRIENIGNEISS * UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE - DEPARTAMENTO DE FISICA TRANS WORLD TIDAL GRAVITY PROFILES P. MELCHIOR CENTRO POLITECNICO

  1. Neural Networks for Signal Processing VII Proceeding of the 1997 IEEE Workshop

    DTIC Science & Technology

    2007-11-02

    Fu, Hsin-Chia and Xu, Y. Y. 626 Neural Networks for Engine Fault Diagnostics Dong, Dawei W., Hopfield , John J., and Unnikrishnan, K. P. 636...June 98 REPORT TYPE AND DATES COVERED Final \\^Q\\ Cf\\ - M DteC ^ TITLE AND SUBTITLE Neural Networks for Signal Processing VII Proceeding...sponsored by the Neural Networks Technical Committee of the IEEE Signal Processing Society, in cooperation with the IEEE Neural Networks Council and

  2. Enhancing MAC performance of DCF protocol for IEEE 802.11 wireless LANs

    NASA Astrophysics Data System (ADS)

    Choi, Woo-Yong

    2017-01-01

    The DCF (Distributed Coordination Function) is the basic MAC (Medium Access Control) protocol of IEEE 802.11 wireless LANs and compatible with various IEEE 802.11 PHY extensions. The performance of the DCF degrades exponentially as the number of nodes participating in the DCF transmission procedure increases. To deal with this problem, we propose a simple, however efficient modification of the DCF by which the performance of the DCF is greatly enhanced.

  3. Validation of IEEE P1547.1 Interconnection Test Procedures: ASCO 7000 Soft Load Transfer System

    SciTech Connect

    Kroposki, B.; Englebretson, S.; Pink, C.; Daley, J.; Siciliano, R.; Hinton, D.

    2003-09-01

    This report presents the preliminary results of testing the ASCO 7000 Soft Load Transfer System according to IEEE P1547.1 procedures. The ASCO system interconnects synchronous generators with the electric power system and provides monitoring and control for the generator and grid connection through extensive protective functions. The purpose of this testing is to evaluate and give feedback on the contents of IEEE Draft Standard P1547.1 Conformance Tests Procedures for Equipment Interconnecting Distributed Resources With Electric Power Systems.

  4. Graphene Trans-Electrode Membranes

    NASA Astrophysics Data System (ADS)

    Kuan, Aaron; Bo, Lu; Rollings, Ryan; Dressen, Don; Branton, Daniel; Golovchenko, Jene

    2014-03-01

    We report an electrical study of suspended single-layer graphene membranes separating reservoirs of electrolyte solution. Because the opposing reservoirs are separated only by an atomically thin membrane, the trans-conductance (ionic current response to a voltage across the membrane) is extremely sensitive to nanoscale defects in the membrane. This sensitivity allows the precise examination and characterization of intrinsic defects in graphene membranes, as well as engineered defects for devices. We will discuss methods for creating single nanopores or distributed defects in our graphene membranes, with the applications of nanopore DNA sequencing and water desalination in mind.

  5. IEEE 1547 and 2030 Standards for Distributed Energy Resources Interconnection and Interoperability with the Electricity Grid

    SciTech Connect

    Basso, T.

    2014-12-01

    Public-private partnerships have been a mainstay of the U.S. Department of Energy and the National Renewable Energy Laboratory (DOE/NREL) approach to research and development. These partnerships also include technology development that enables grid modernization and distributed energy resources (DER) advancement, especially renewable energy systems integration with the grid. Through DOE/NREL and industry support of Institute of Electrical and Electronics Engineers (IEEE) standards development, the IEEE 1547 series of standards has helped shape the way utilities and other businesses have worked together to realize increasing amounts of DER interconnected with the distribution grid. And more recently, the IEEE 2030 series of standards is helping to further realize greater implementation of communications and information technologies that provide interoperability solutions for enhanced integration of DER and loads with the grid. For these standards development partnerships, for approximately $1 of federal funding, industry partnering has contributed $5. In this report, the status update is presented for the American National Standards IEEE 1547 and IEEE 2030 series of standards. A short synopsis of the history of the 1547 standards is first presented, then the current status and future direction of the ongoing standards development activities are discussed.

  6. The scalable coherent interface, IEEE P1596, status and possible applications to data acquisition and physics

    SciTech Connect

    Gustavson, D.B.

    1990-01-01

    IEEE P1596, the Scalable Coherent Interface (formerly known as SuperBus) is based on experience gained while developing Fastbus (ANSI/IEEE 960-1986, IEC 935), Futurebus (IEEE P896.x) and other modern 32-bit buses. SCI goals include a minimum bandwidth of 1 GByte/sec per processor in multiprocessor systems with thousands of processors; efficient support of a coherent distributed-cache image of distributed shared memory; support for repeaters which interface to existing or future buses; and support for inexpensive small rings as well as for general switched interconnections like Banyan, Omega, or crossbar networks. This paper presents a summary of current directions, reports the status of the work in progress, and suggests some applications in data acquisition and physics. 7 refs.

  7. IEEE 1451.2 based Smart sensor system using ADuc847

    NASA Astrophysics Data System (ADS)

    Sreejithlal, A.; Ajith, Jose

    IEEE 1451 standard defines a standard interface for connecting transducers to microprocessor based data acquisition systems, instrumentation systems, control and field networks. Smart transducer interface module (STIM) acts as a unit which provides signal conditioning, digitization and data packet generation functions to the transducers connected to it. This paper describes the implementation of a microcontroller based smart transducer interface module based on IEEE 1451.2 standard. The module, implemented using ADuc847 microcontroller has 2 transducer channels and is programmed using Embedded C language. The Sensor system consists of a Network Controlled Application Processor (NCAP) module which controls the Smart transducer interface module (STIM) over an IEEE1451.2-RS232 bus. The NCAP module is implemented as a software module in C# language. The hardware details, control principles involved and the software implementation for the STIM are described in detail.

  8. An Analytical Model for the Performance Analysis of Concurrent Transmission in IEEE 802.15.4

    PubMed Central

    Gezer, Cengiz; Zanella, Alberto; Verdone, Roberto

    2014-01-01

    Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions. PMID:24658624

  9. Performance Analysis of Sleep Mode Operation in IEEE 802.16m Mobile WiMAX

    NASA Astrophysics Data System (ADS)

    Baek, Sangkyu; Son, Jung Je; Choi, Bong Dae

    We mathematically analyze the sleep mode operation of IEEE 802.16m. The sleep mode operation for downlink traffic is modeled as a 3-dimensional discrete time Markov chain. We obtain the average power consumption of a mobile station and the average delay of a message. Numerical results match simulations very well. Numerical results show that there is a tradeoff between power consumption and message delay. We find the optimal lengths of sleep cycle and close-down time that minimize the power consumption while satisfying the quality of service (QoS) constraint on message delay. The power consumption of the sleep mode in IEEE 802.16m is better than that of sleep modes in legacy IEEE 802.16e standard under the same delay bound.

  10. Throughput and delay analysis of IEEE 802.15.6-based CSMA/CA protocol.

    PubMed

    Ullah, Sana; Chen, Min; Kwak, Kyung Sup

    2012-12-01

    The IEEE 802.15.6 is a new communication standard on Wireless Body Area Network (WBAN) that focuses on a variety of medical, Consumer Electronics (CE) and entertainment applications. In this paper, the throughput and delay performance of the IEEE 802.15.6 is presented. Numerical formulas are derived to determine the maximum throughput and minimum delay limits of the IEEE 802.15.6 for an ideal channel with no transmission errors. These limits are derived for different frequency bands and data rates. Our analysis is validated by extensive simulations using a custom C+ + simulator. Based on analytical and simulation results, useful conclusions are derived for network provisioning and packet size optimization for different applications.

  11. An analytical model for the performance analysis of concurrent transmission in IEEE 802.15.4.

    PubMed

    Gezer, Cengiz; Zanella, Alberto; Verdone, Roberto

    2014-03-20

    Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions.

  12. Efficiency testing of medium induction motors: A comment on IEEE Std 112-1991

    SciTech Connect

    Gray, G.G.; Martiny, W.J.

    1996-09-01

    The energy crisis of 1973 focused attention on the efficiency of polyphase induction motors, and the need to have a test procedure that was repeatable and accurate. Medium induction motors, especially those in the size range 1 through 125 horsepower, were important because of the large number in service and the fact that a significant efficiency improvement through redesign was economically feasible. In response to this the ANSI/IEEE Std. 112, ``IEEE Standard Test Procedure for Polyphase Induction Motors and Generators`` Method B was chosen for testing medium ac motors for efficiency. The current version IEEE std. 112-1991 Method B contains several requirements for accuracy improvement which have been found to be effective. Even though the Method B procedure with the additional accuracy requirement has been in use since 1984 no rational has been published to support these extra requirements. The paper discusses the purpose of these improvements, and also point out some weakness in procedure.

  13. Introduction to IEEE-EMBS -- What Can the Society Do for You?

    PubMed

    Oakley, Barbara; Lazareck, Lisa; Wolf, Laura

    2005-01-01

    IEEE-EMBS is the largest bioengineering society in the world. This paper introduces material about the Society and its benefits, including the EMBS mission, types of EMBS membership, and direct membership benefits such as the EMB Magazine. EMBS governance is also explained, including the new worldwide representational organization for AdCom (Administrative Committee), and recent changes in the Executive Committee. EMBS delegates to other societies are described, as well as the infrastructure of the main office and duties of key personnel there. Infostructure efforts related to the website and web-based conference registration and manuscript submission are also briefly discussed. Publications sponsored and co-sponsored by EMBS are reviewed. Plans for future national conferences are put forth. The various EMBS awards are outlined. Context is provided for the relationship between IEEE and EMBS, and a brief description is provided of IEEE organization and benefits.

  14. Applying IEEE storage system management standards at the National Storage Laboratory

    SciTech Connect

    Louis, S.; Hyer, S.W.

    1992-12-04

    Since its inception in 1990, the IEEE Storage System Standards Working Group has identified storage-system management as an area in need of further development The pressing need for standards in storage-system management arises from the requirement to exchange management information and to provide control in a consistent predictable manner between the components of a storage system. An appropriate set of management standards will allow multiple vendors to supply storage management subsystems or applications that are integral to or compatible with new storage systems conforming to future IEEE standards. An early, practical application of IEEE storage-system-management work is being pursued at the National Storage Laboratory (NSL), a recently-formed industrial collaboration at Lawrence Livermore National Laboratory. The NSL`s purpose is to develop advanced hardware and software technologies for high-performance, distributed storage systems. Since storage system management is of critical concern, it is being explored in depth at the NSL. Work was initiated to define basic management requirements and develop generalized graphical-user-interface tools using remote-procedure-call mechanisms to implement the NSL`s conceptual management framework. Several constraints were imposed on the development of early versions of this work to maintain compatibility with the NSL`s underlying UniTree-based software architecture and to provide timely prototypes and proof of concept. The project leverages the on-going standards work of the IEEE Storage System Standards Working Group (SSSWG) and also explores some of the relationships and interactions between IEEE storage-system management and more well known management methods for distributed systems and networks. It will have long term benefits by providing ``real-life`` storage-system-management requirements to the IEEE SSSWG for validation of evolving standards.

  15. Suicide protective factors among trans adults.

    PubMed

    Moody, Chérie; Smith, Nathan Grant

    2013-07-01

    A recent study indicated a suicide attempt rate of 41 % among trans (e.g., trans, transgender, transexual/transsexual, genderqueer, two-spirit) individuals. Although this rate is alarming, there is a dearth of literature regarding suicide prevention for trans individuals. A vital step in developing suicide prevention models is the identification of protective factors. It was hypothesized that social support from friends, social support from family, optimism, reasons for living, and suicide resilience, which are known to protect cis (non-trans) individuals, also protect trans individuals. A sample of self-identified trans Canadian adults (N = 133) was recruited from LGBT and trans LISTSERVs. Data were collected online using a secure survey platform. A three block hierarchical multiple regression model was used to predict suicidal behavior from protective factors. Social support from friends, social support from family, and optimism significantly and negatively predicted 33 % of variance in participants' suicidal behavior after controlling for age. Reasons for living and suicide resilience accounted for an additional 19 % of the variance in participants' suicidal behavior after controlling for age, social support from friends, social support from family, and optimism. Of the factors mentioned above, perceived social support from family, one of three suicide resilience factors (emotional stability), and one of six reasons for living (child-related concerns) significantly and negatively predicted participants' suicidal behavior. Overall, these findings can be used to inform the practices of mental health workers, medical doctors, and suicide prevention workers working with trans clients.

  16. Design of acquisition devices management subsystem for IEEE 1073 compliant software agents.

    PubMed

    Nagin, V A; Potapov, I V; Selishchev, S V

    2002-01-01

    The paper addresses the issue of device management system design for software agents compliant with IEEE 1073 device communication standard. Based on middleware architecture the device control layer represents a universal versatile object-oriented application-programming interface. The approach presented in the paper allows to implement plug-and-play integration and interoperability of medical acquisition devices within the medical device system be means of common middleware services. Adherence to Medical Data Information Base nomenclature, component part of IEEE 1073 communication standard, adds necessary consistency to presented component-based infrastructure.

  17. Maxi program at IEEE EMBS Student Club of Beijing University of Posts and Telecommunications.

    PubMed

    Wu, Yunfeng; Tao, Ningning; Tang, Luxian; Ma, Xu; Garcia, Gonzalo A; Mitsui, Mie

    2004-01-01

    This paper presents the recently launched Maxi Program at IEEE EMBS Student Club of Beijing University of Posts and Telecommunications. The program initiates a variety of seminar series covering biomedical expertise and professional communication skills, forms a cooperative partnership between students, university and industry through guest speakers events and industry tours, and sets in motion personal consultative services (PCS) to foster the individualized competence of students. This extended program could be an innovative model of self-development as an affiliated student chapter/club with IEEE EMBS.

  18. Cis and Trans Isomers of Cycloalkenes

    NASA Astrophysics Data System (ADS)

    Barrows, Susan E.; Eberlein, Thomas H.

    2005-09-01

    As a rule, a trans disubstituted alkene is more stable than the corresponding cis isomer. For cycloalkenes of fewer than eleven members, cis isomers are more stable than their trans counterparts. Although this exception to the normal rule is occasionally noted in beginning organic chemistry textbooks, it is often done without a careful analysis of the reasons behind it. The purpose of this article is to provide that analysis. In order for a cycloalkene to accommodate a trans double bond one or more of the following nonideal geometries must occur: a twisted π bond; pyramidal sp 2 -carbon atoms; nonideal sp 3 bond angles; or longer than normal C C single and double bonds. This article provides a list of experimentally determined relative energies of the cis and trans isomers within the series cycloheptene cycloundecene, along with computationally derived energies at several levels of theory. It also examines the geometric distortions through which cycloalkenes relieve the strain introduced by a trans double bond.

  19. Application of the Method of Auxiliary Sources for the Analysis of Plane-Wave Scattering by Impedance Spheres

    DTIC Science & Technology

    2002-09-01

    in good agreement with the reference spherical wave expansion (SWE) solution. REFERENCES [1] Y. Leviatan et al., IEEE Trans. Antennas Propagat., vol...2002 [5] Y. Leviatan et al., IEEE Trans. Antennas Propagat., vol. 38, 1259-1263, Aug. 1990 [6] J. E. Hansen, Spherical Near-Field Antenna

  20. Evaluation of H.264/AVC over IEEE 802.11p vehicular networks

    NASA Astrophysics Data System (ADS)

    Rozas-Ramallal, Ismael; Fernández-Caramés, Tiago M.; Dapena, Adriana; García-Naya, José Antonio

    2013-12-01

    The capacity of vehicular networks to offer non-safety services, like infotainment applications or the exchange of multimedia information between vehicles, have attracted a great deal of attention to the field of Intelligent Transport Systems (ITS). In particular, in this article we focus our attention on IEEE 802.11p which defines enhancements to IEEE 802.11 required to support ITS applications. We present an FPGA-based testbed developed to evaluate H.264/AVC (Advanced Video Coding) video transmission over vehicular networks. The testbed covers some of the most common situations in vehicle-to-vehicle and roadside-to-vehicle communications and it is highly flexible, allowing the performance evaluation of different vehicular standard configurations. We also show several experimental results to illustrate the quality obtained when H.264/AVC encoded video is transmitted over IEEE 802.11p networks. The quality is measured considering two important parameters: the percentage of recovered group of pictures and the frame quality. In order to improve performance, we propose to substitute the convolutional channel encoder used in IEEE 802.11p for a low-density parity-check code encoder. In addition, we suggest a simple strategy to decide the optimum number of iterations needed to decode each packet received.

  1. IEEE 1547 National Standard for Interconnecting Distributed Generation: How Could It Help My Facility? Preprint

    SciTech Connect

    Basso, T.; Friedman, N. R.

    2003-11-01

    This article summarizes the purpose, development, and impact of the Institute of Electrical and Electronics Engineers 1547 Standard for Interconnecting Distributed Resources With Electric Power Systems. Also included is a short explanation of supporting standards IEEE P1547.1, P1547.2, and P1547.3.

  2. Evaluation of the Effects of Hidden Node Problems in IEEE 802.15.7 Uplink Performance

    PubMed Central

    Ley-Bosch, Carlos; Alonso-González, Itziar; Sánchez-Rodríguez, David; Ramírez-Casañas, Carlos

    2016-01-01

    In the last few years, the increasing use of LEDs in illumination systems has been conducted due to the emergence of Visible Light Communication (VLC) technologies, in which data communication is performed by transmitting through the visible band of the electromagnetic spectrum. In 2011, the Institute of Electrical and Electronics Engineers (IEEE) published the IEEE 802.15.7 standard for Wireless Personal Area Networks based on VLC. Due to limitations in the coverage of the transmitted signal, wireless networks can suffer from the hidden node problems, when there are nodes in the network whose transmissions are not detected by other nodes. This problem can cause an important degradation in communications when they are made by means of the Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA) access control method, which is used in IEEE 802.15.7 This research work evaluates the effects of the hidden node problem in the performance of the IEEE 802.15.7 standard We implement a simulator and analyze VLC performance in terms of parameters like end-to-end goodput and message loss rate. As part of this research work, a solution to the hidden node problem is proposed, based on the use of idle patterns defined in the standard. Idle patterns are sent by the network coordinator node to communicate to the other nodes that there is an ongoing transmission. The validity of the proposed solution is demonstrated with simulation results. PMID:26861352

  3. Some problems of implementation: ANSI/IEEE Std 1149.1 in microcontroller design

    NASA Astrophysics Data System (ADS)

    Adamkiewicz, Hubert; Glinski, Krzysztof; Lewandowski, Artur

    1992-08-01

    The paper presents some problems of implementation ANSI/IEEE Std 1149.1 worked out in the Industrial Institute of Electronics (PIE) microcontroller board. Diagnostic properties of some special hardware solutions and examples of testing procedures are described. Testing was performed with the help of the PIE diagnostic bus analyzer.

  4. Evaluation of the Effects of Hidden Node Problems in IEEE 802.15.7 Uplink Performance.

    PubMed

    Ley-Bosch, Carlos; Alonso-González, Itziar; Sánchez-Rodríguez, David; Ramírez-Casañas, Carlos

    2016-02-06

    In the last few years, the increasing use of LEDs in illumination systems has been conducted due to the emergence of Visible Light Communication (VLC) technologies, in which data communication is performed by transmitting through the visible band of the electromagnetic spectrum. In 2011, the Institute of Electrical and Electronics Engineers (IEEE) published the IEEE 802.15.7 standard for Wireless Personal Area Networks based on VLC. Due to limitations in the coverage of the transmitted signal, wireless networks can suffer from the hidden node problems, when there are nodes in the network whose transmissions are not detected by other nodes. This problem can cause an important degradation in communications when they are made by means of the Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA) access control method, which is used in IEEE 802.15.7 This research work evaluates the effects of the hidden node problem in the performance of the IEEE 802.15.7 standard We implement a simulator and analyze VLC performance in terms of parameters like end-to-end goodput and message loss rate. As part of this research work, a solution to the hidden node problem is proposed, based on the use of idle patterns defined in the standard. Idle patterns are sent by the network coordinator node to communicate to the other nodes that there is an ongoing transmission. The validity of the proposed solution is demonstrated with simulation results.

  5. Computer Controlled Test Systems. Introduction. A Course Based on the IEEE 488 Bus.

    ERIC Educational Resources Information Center

    Herrmann, Eric J.

    An introductory course in computer automated tests and measurement systems based on the International Test Instrument-Computer Interface Standard, the IEEE (Institute of Electrical and Electronics Engineers)-488, is presented in this study guide. This course is designed to: (1) introduce the electronics engineering technician to the functional…

  6. Comparison of IEC and IEEE Standards for Computer-Based Control Systems Important to Safety

    SciTech Connect

    Johnson, G.

    2001-12-19

    The collections of IEEE and 1EC standards have some overlap, but in many cases cover significantly different topics. For example, 1EEE standards go to great depth on environmental qualification of many specific types of components, while IEC covers the topic only at the general level. Conversely, certain IEC standards deal with specific instrumentation and control functions, a topic area where IEEE standards are largely mute. This paper studies two questions related to the above observations. Which standards in each body should be coordinated with each other? What opportunities exist for the two bodies to build on each other's standards to efficiently improve upon the coverage of their sets of standards? Poor coordination between the two sets of standards poses a problem for the developers of systems for plant upgrades. Developers must try to address both sets of standards to avail themselves of a sufficiently broad market. Additionally, the IEEE and IEC standards together form a more comprehensive set of guidance than either set alone. If the interfaces between the standard sets were smoother, plant staff and system designers would have a better set of tools to help in the design and specification of I and C upgrades. To understand the similarities and differences between 1EC and IEEE nuclear power standards layer diagrams were developed for each set of standards.

  7. IEEE802.15.6 -based multi-accelerometer WBAN system for monitoring Parkinson's disease.

    PubMed

    Keränen, Niina; Särestöniemi, Mariella; Partala, Juha; Hämäläinen, Matti; Reponen, Jarmo; Seppänen, Tapio; Iinatti, Jari; Jämsä, Timo

    2013-01-01

    In this paper we present a detailed example of a wireless body area network (WBAN) scenario utilizing the recent IEEE802.15.6 standard as applied to a multi-accelerometer system for monitoring Parkinson's disease and fall detection. Ultra wideband physical layer and standard security protocols are applied to meet application requirements for data rate and security.

  8. IEEE Radio and Wireless Symposium Student Awards Support Request: 2010-2012

    DTIC Science & Technology

    2012-01-01

    System for E-GSM900 and DCS1800 Cellular Phone Networks for Search and Rescue Applications, IEEE WiSNET (09 2011) A. Cagri Ulusoy , Gang Liu, Andreas...Receiver for Multi-Gigabit Wireless Communications Cagri Ulusoy *, Gang Liu*, Andreas Trasser*, S´ebastien Chartier# and Hermann Schumacher* Ulm University

  9. Trans-Pacific Astronomy Experiment Project Status

    NASA Technical Reports Server (NTRS)

    Hsu, Eddie

    2000-01-01

    The Trans-Pacific Astronomy Experiment is Phase 2 of the Trans-Pacific High Data Rate Satcom Experiments following the Trans-Pacific High Definition Video Experiment. It is a part of the Global Information Infrastructure-Global Interoperability for Broadband Networks Project (GII-GIBN). Provides global information infrastructure involving broadband satellites and terrestrial networks and access to information by anyone, anywhere, at any time. Collaboration of government, industry, and academic organizations demonstrate the use of broadband satellite links in a global information infrastructure with emphasis on astronomical observations, collaborative discussions and distance learning.

  10. Perspectives on development of IEEE 1073: the Medical Information Bus (MIB) standard.

    PubMed

    Kennelly, R J; Gardner, R M

    1997-08-01

    Automated data capture from bedside patient medical devices is now possible using a new Institute of Electrical and Electronic Engineering (IEEE) and American National Standards Institute (ANSI) Medical Information Bus (MIB) data communications standard (IEEE 1073). The first two standard documents, IEEE 1073.3.1 (Transportation Profile) and IEEE 1073.4.1 (Physical Layer), define the hardware protocol for bedside device communications. With the above noted IEEE MIB standards in place, hospitals can now start designing customized applications for acquiring data from bedside devices such as bedside monitors, i.v. pumps, ventilators, etc. for multiple purposes. The hardware 'plug and play' features of the MIB will enable nurses and physicians to establish communications with these devices simply and conveniently by plugging them into a bedside data connector. No other action will be necessary to establish identification of the device or communications with the device. Presently to connect bedside devices, technical help from hardware and software experts are required to establish such communications links. As a result of standardization of communications, it will be easy to establish a highly mobile network of bedside devices and more promptly and efficiently collect patient related data. Collection of data automatically should lead to the design of new medical computing applications that will tie in directly with the emerging mission and operations of hospitals. The MIB will permit acquisition of patient data more efficiently with greater accuracy, more completeness and more promptly. The above noted features are all essential to the development of computerized treatment protocols and should lead to improved quality of patient care. This manuscript provides the rational and historical overview of the development of the MIB standard.

  11. IEEE 802.16J-Relay Fortified Aeromacs Networks; Benefits and Challenges

    NASA Technical Reports Server (NTRS)

    Kamali, Behnam; Apaza, Rafael D.

    2014-01-01

    Aeronautical Mobile Airport Communications System (AeroMACS) is an IEEE 802.16 standard-based (WiMAX) broadband aviation transmission technology, developed to provide safety critical communications coverage for airport surface in support of fixed and mobile ground to ground applications and services. We have previously demonstrated that IEEE 802.16j-amendment-based WiMAX is most feasible for AeroMACS applications. The principal argument in favor of application of IEEE 802.16j technology is the flexible and cost effective extension of radio coverage that is afforded by relay fortified WiMAX networks, with virtually no increase in the power requirements. In this article, following introductory remarks on airport surface communications, WiMAX and AeroMACS; the IEEE 802.16j-based WiMAX technology and multihop relay systems are briefly described. The two modes of relay operation supported by IEEE 802.16j amendment; i.e., transparent (TRS) and non-transparent (NTRS) modes, are discussed in some detail. Advantages and disadvantages of using TRS and NTRS in AeroMACS networks are summarized in a table. Practical issues vis--vis the inclusion of relays in AeroMACS networks are addressed. It is argued that the selection of relay type may affect a number of network parameters. A discussion on specific benefits and challenges of inclusion of relays in AeroMACS networks is provided. The article concludes that in case it is desired or necessary to exclusively employ one type of relay mode for all applications throughout an AeroMACS network, the proper selection would be the non-transparent mode.

  12. Structural aspects of trans-translation.

    PubMed

    Shpanchenko, Olga V; Golovin, Andrey V; Bugaeva, Elizaveta Y; Isaksson, Leif A; Dontsova, Olga A

    2010-02-01

    trans-Translation is a process which the bacterial cells apply to rescue the ribosomes that are arrested during the translation of damaged mRNA and to get rid of the mRNA and the product polypeptide. In the course of trans-translation, the mRNA-like domain of tmRNA replaces the nonstop messenger RNA bound to the ribosome. Although several structural elements of tmRNA and SmpB known to be essential for correct determination of resume codon, the molecular mechanism of trans-translation is not well understood. Computer modeling has been used to develop a model for the spatial organization of the tmRNA inside the ribosome at different stages of trans-translation leading to a proposal for the mechanism of the template-switching process.

  13. Performance of the Sleep-Mode Mechanism of the New IEEE 802.16m Proposal for Correlated Downlink Traffic

    NASA Astrophysics Data System (ADS)

    de Turck, Koen; de Vuyst, Stijn; Fiems, Dieter; Wittevrongel, Sabine; Bruneel, Herwig

    There is a considerable interest nowadays in making wireless telecommunication more energy-efficient. The sleep-mode mechanism in WiMAX (IEEE 802.16e) is one of such energy saving measures. Recently, Samsung proposed some modifications on the sleep-mode mechanism, scheduled to appear in the forthcoming IEEE 802.16m standard, aimed at minimizing the signaling overhead. In this work, we present a performance analysis of this proposal and clarify the differences with the standard mechanism included in IEEE 802.16e. We also propose some special algorithms aimed at reducing the computational complexity of the analysis.

  14. A Novel IEEE 802.15.4e DSME MAC for Wireless Sensor Networks

    PubMed Central

    Sahoo, Prasan Kumar; Pattanaik, Sudhir Ranjan; Wu, Shih-Lin

    2017-01-01

    IEEE 802.15.4e standard proposes Deterministic and Synchronous Multichannel Extension (DSME) mode for wireless sensor networks (WSNs) to support industrial, commercial and health care applications. In this paper, a new channel access scheme and beacon scheduling schemes are designed for the IEEE 802.15.4e enabled WSNs in star topology to reduce the network discovery time and energy consumption. In addition, a new dynamic guaranteed retransmission slot allocation scheme is designed for devices with the failure Guaranteed Time Slot (GTS) transmission to reduce the retransmission delay. To evaluate our schemes, analytical models are designed to analyze the performance of WSNs in terms of reliability, delay, throughput and energy consumption. Our schemes are validated with simulation and analytical results and are observed that simulation results well match with the analytical one. The evaluated results of our designed schemes can improve the reliability, throughput, delay, and energy consumptions significantly. PMID:28275216

  15. A nomadic access mechanism for enabling dynamic video surveillance over IEEE 802.15.4 networks

    NASA Astrophysics Data System (ADS)

    Garcia-Sanchez, Felipe; Garcia-Sanchez, Antonio-Javier; Losilla, Fernando; Garcia-Haro, Joan

    2010-12-01

    IEEE 802.15.4 networking technology is designed to be the common standard for integrating WSN applications in heterogeneous environments. However, applications considering mobile nodes along with strict temporal requirements, such as those required for video transmission, are an unexplored field for this technology. These applications involve different challenges and issues that the direct employment of the IEEE 802.15.4 standard does not resolve. Therefore, in this paper a cross-layer mechanism consisting of application and medium access arbitration is presented, enabling the efficient connection and operation of mobile nodes together with the transmission of video flows. The proposed mechanism is evaluated via simulation and its feasibility checked by means of a first prototype. The study of power consumption is also taken into account and so are the quality of service parameters and the human quality perception of the received video stream. The results obtained are presented and further discussed.

  16. Performance Evolution of IEEE 802.11b Wireless Local Area Network

    NASA Astrophysics Data System (ADS)

    Malik, Deepak; Singhal, Ankur

    2011-12-01

    The Wireless network can be employed to connect wired network to the wireless network. Wireless local area networks (WLAN) are more bandwidth limited as compared to the wired networks because they rely on an inexpensive, but error prone, physical medium (air). Hence it is important to evaluate their performance. This paper presents a study of IEEE 802.11b wireless LAN (WLAN). The performance evaluation has been presented via a series of test with different parameters such as data rate, different number of nodes and physical characteristics. The different qualities of service parameter are chosen to be throughput, media access delay and dropped data packets. The simulation results show that an IEEE 802.11b WLAN can support up to 60 clients with modest throughput. Finally the results are compared to evaluate the performance of wireless local networks.

  17. A Novel IEEE 802.15.4e DSME MAC for Wireless Sensor Networks.

    PubMed

    Sahoo, Prasan Kumar; Pattanaik, Sudhir Ranjan; Wu, Shih-Lin

    2017-01-16

    IEEE 802.15.4e standard proposes Deterministic and Synchronous Multichannel Extension (DSME) mode for wireless sensor networks (WSNs) to support industrial, commercial and health care applications. In this paper, a new channel access scheme and beacon scheduling schemes are designed for the IEEE 802.15.4e enabled WSNs in star topology to reduce the network discovery time and energy consumption. In addition, a new dynamic guaranteed retransmission slot allocation scheme is designed for devices with the failure Guaranteed Time Slot (GTS) transmission to reduce the retransmission delay. To evaluate our schemes, analytical models are designed to analyze the performance of WSNs in terms of reliability, delay, throughput and energy consumption. Our schemes are validated with simulation and analytical results and are observed that simulation results well match with the analytical one. The evaluated results of our designed schemes can improve the reliability, throughput, delay, and energy consumptions significantly.

  18. Integration of IEEE 1451 and HL7 exchanging information for patients' sensor data.

    PubMed

    Kim, Wooshik; Lim, Suyoung; Ahn, Jinsoo; Nah, Jiyoung; Kim, Namhyun

    2010-12-01

    HL7 (Health Level 7) is a standard developed for exchanging incompatible healthcare information generated from programs or devices among heterogenous medical information systems. At present, HL7 is growing as a global standard. However, the HL7 standard does not support effective methods for treating data from various medical sensors, especially from mobile sensors. As ubiquitous systems are growing, HL7 must communicate with various medical transducers. In the area of sensor fields, IEEE 1451 is a group of standards for controlling transducers and for communicating data from/to various transducers. In this paper, we present the possibility of interoperability between the two standards, i.e., HL7 and IEEE 1451. After we present a method to integrate them and show the preliminary results of this approach.

  19. A note on bound constraints handling for the IEEE CEC'05 benchmark function suite.

    PubMed

    Liao, Tianjun; Molina, Daniel; de Oca, Marco A Montes; Stützle, Thomas

    2014-01-01

    The benchmark functions and some of the algorithms proposed for the special session on real parameter optimization of the 2005 IEEE Congress on Evolutionary Computation (CEC'05) have played and still play an important role in the assessment of the state of the art in continuous optimization. In this article, we show that if bound constraints are not enforced for the final reported solutions, state-of-the-art algorithms produce infeasible best candidate solutions for the majority of functions of the IEEE CEC'05 benchmark function suite. This occurs even though the optima of the CEC'05 functions are within the specified bounds. This phenomenon has important implications on algorithm comparisons, and therefore on algorithm designs. This article's goal is to draw the attention of the community to the fact that some authors might have drawn wrong conclusions from experiments using the CEC'05 problems.

  20. [Mobile Health: IEEE Standard for Wearable Cuffless Blood Pressure Measuring Devices].

    PubMed

    Zhou, Xia; Wu, Wenli; Bao, Shudi

    2015-07-01

    IEEE Std 1708-2014 breaks through the traditional standards of cuff based blood pressure measuring devices and establishes a normative definition of wearable cuffless blood pressure measuring devices and the objective performance evaluation of this kind of devices. This study firstly introduces the background of the new standard. Then, the standard details will be described, and the impact of cuffless blood pressure measuring devices with the new standard on manufacturers and end users will be addressed.

  1. Sensor Networking Testbed with IEEE 1451 Compatibility and Network Performance Monitoring

    NASA Technical Reports Server (NTRS)

    Gurkan, Deniz; Yuan, X.; Benhaddou, D.; Figueroa, F.; Morris, Jonathan

    2007-01-01

    Design and implementation of a testbed for testing and verifying IEEE 1451-compatible sensor systems with network performance monitoring is of significant importance. The performance parameters measurement as well as decision support systems implementation will enhance the understanding of sensor systems with plug-and-play capabilities. The paper will present the design aspects for such a testbed environment under development at University of Houston in collaboration with NASA Stennis Space Center - SSST (Smart Sensor System Testbed).

  2. An NTP Stratum-One Server Farm Fed By IEEE-1588

    DTIC Science & Technology

    2010-01-01

    42 nd Annual Precise Time and Time Interval (PTTI) Meeting 111 AN NTP STRATUM-ONE SERVER FARM FED BY IEEE-1588 Richard E...Schmidt and Blair Fonville Time Service Department, U.S. Naval Observatory 3450 Massachusetts Ave. NW, Washington, D.C. 20392, USA rich.schmidt...usno.navy.mil, blair.fonville@usno.navy.mil Abstract For the past 16 years, USNO’s Network Time Protocol (NTP) stratum-1 servers have been

  3. Interpretation of IEEE-854 floating-point standard and definition in the HOL system

    NASA Technical Reports Server (NTRS)

    Carreno, Victor A.

    1995-01-01

    The ANSI/IEEE Standard 854-1987 for floating-point arithmetic is interpreted by converting the lexical descriptions in the standard into mathematical conditional descriptions organized in tables. The standard is represented in higher-order logic within the framework of the HOL (Higher Order Logic) system. The paper is divided in two parts with the first part the interpretation and the second part the description in HOL.

  4. Preparation and characterization of trans-RhCl(CO)(TPPTS){sub 2}-intercalated layered double hydroxides

    SciTech Connect

    Zhang Xian; Wei Min; Pu Min; Li Xianjun; Chen Hua; Evans, David G.; Duan Xue . E-mail: duanx@mail.buct.edu.cn

    2005-09-15

    trans-RhCl(CO)(TPPTS){sub 2} (TPPTS=tris(m-sulfonatophenyl)phosphine) has been intercalated into Zn-Al layered double hydroxides (LDHs) by the method of ion exchange. The structure, composition and thermal stability of the composite material have been characterized by powder X-ray diffraction, Fourier transform infrared and {sup 31}P solid-state magic-angle spinning nuclear magnetic resonance spectroscopy, elemental analysis, thermogravimetry, and differential thermal analysis. The geometry of trans-RhCl(CO)(TPPTS){sub 2} was fully optimized using the PM3 semiempirical molecular orbital method, and a schematic model for the intercalated species has been proposed. The thermal stability of trans-RhCl(CO)(TPPTS){sub 2} is significantly enhanced by intercalation, which suggests that such materials may have prospective application as the basis of a supported catalyst system for the hydroformylation of higher olefins.

  5. Preparation and characterization of trans-RhCl(CO)(TPPTS) 2-intercalated layered double hydroxides

    NASA Astrophysics Data System (ADS)

    Zhang, Xian; Wei, Min; Pu, Min; Li, Xianjun; Chen, Hua; Evans, David G.; Duan, Xue

    2005-09-01

    trans-RhCl(CO)(TPPTS) 2 (TPPTS= tris( m-sulfonatophenyl)phosphine) has been intercalated into Zn-Al layered double hydroxides (LDHs) by the method of ion exchange. The structure, composition and thermal stability of the composite material have been characterized by powder X-ray diffraction, Fourier transform infrared and 31P solid-state magic-angle spinning nuclear magnetic resonance spectroscopy, elemental analysis, thermogravimetry, and differential thermal analysis. The geometry of trans-RhCl(CO)(TPPTS) 2 was fully optimized using the PM3 semiempirical molecular orbital method, and a schematic model for the intercalated species has been proposed. The thermal stability of trans-RhCl(CO)(TPPTS) 2 is significantly enhanced by intercalation, which suggests that such materials may have prospective application as the basis of a supported catalyst system for the hydroformylation of higher olefins.

  6. Segmentized Clear Channel Assessment for IEEE 802.15.4 Networks.

    PubMed

    Son, Kyou Jung; Hong, Sung Hyeuck; Moon, Seong-Pil; Chang, Tae Gyu; Cho, Hanjin

    2016-06-03

    This paper proposed segmentized clear channel assessment (CCA) which increases the performance of IEEE 802.15.4 networks by improving carrier sense multiple access with collision avoidance (CSMA/CA). Improving CSMA/CA is important because the low-power consumption feature and throughput performance of IEEE 802.15.4 are greatly affected by CSMA/CA behavior. To improve the performance of CSMA/CA, this paper focused on increasing the chance to transmit a packet by assessing precise channel status. The previous method used in CCA, which is employed by CSMA/CA, assesses the channel by measuring the energy level of the channel. However, this method shows limited channel assessing behavior, which comes from simple threshold dependent channel busy evaluation. The proposed method solves this limited channel decision problem by dividing CCA into two groups. Two groups of CCA compare their energy levels to get precise channel status. To evaluate the performance of the segmentized CCA method, a Markov chain model has been developed. The validation of analytic results is confirmed by comparing them with simulation results. Additionally, simulation results show the proposed method is improving a maximum 8.76% of throughput and decreasing a maximum 3.9% of the average number of CCAs per packet transmission than the IEEE 802.15.4 CCA method.

  7. On IEEE 802.15.6 IR-UWB receivers - simulations for DBPSK modulation.

    PubMed

    Niemelä, Ville; Hämäläinen, Matti; Iinatti, Jari

    2013-01-01

    In 2002, Federal Communications Commission (FCC) was the first in defining regulations for ultra wideband (UWB) communications followed by Europe and Japan some years later. Focusing on impulse radio (IR) UWB, in 2007 was the time for the first published standard targeting in personal area networks, released by the IEEE. The second IEEE released standard including UWB definitions is targeted for wireless body area networks (WBAN) and was published in 2012. As the wireless communications has been and will be passing through almost any levels in society, the natural step with WBAN is using it in different medical, healthcare and wellbeing applications. The arguments for these are related to the modern lifestyle, in which people have increasingly more free time and are more interested in taking care of their health and wellbeing. Another challenge is the population composition, i.e., aging in developed countries which call for new solutions and procedures, particularly from cost wise. In this paper, we are evaluating UWB receivers based on the IEEE 802.15.6 physical layer definitions and capable of detecting differentially encoded modulation. The evaluation is performed using two different WBAN channel models.

  8. Strategies for Optimal MAC Parameters Tuning in IEEE 802.15.6 Wearable Wireless Sensor Networks.

    PubMed

    Alam, Muhammad Mahtab; Ben Hamida, Elyes

    2015-09-01

    Wireless body area networks (WBAN) has penetrated immensely in revolutionizing the classical heath-care system. Recently, number of WBAN applications has emerged which introduce potential limits to existing solutions. In particular, IEEE 802.15.6 standard has provided great flexibility, provisions and capabilities to deal emerging applications. In this paper, we investigate the application-specific throughput analysis by fine-tuning the physical (PHY) and medium access control (MAC) parameters of the IEEE 802.15.6 standard. Based on PHY characterizations in narrow band, at the MAC layer, carrier sense multiple access collision avoidance (CSMA/CA) and scheduled access protocols are extensively analyzed. It is concluded that, IEEE 802.15.6 standard can satisfy most of the WBANs applications throughput requirements by maximum achieving 680 Kbps. However, those emerging applications which require high quality audio or video transmissions, standard is not able to meet their constraints. Moreover, delay, energy efficiency and successful packet reception are considered as key performance metrics for comparing the MAC protocols. CSMA/CA protocol provides the best results to meet the delay constraints of medical and non-medical WBAN applications. Whereas, the scheduled access approach, performs very well both in energy efficiency and packet reception ratio.

  9. Interoperability in digital electrocardiography: harmonization of ISO/IEEE x73-PHD and SCP-ECG.

    PubMed

    Trigo, Jesús D; Chiarugi, Franco; Alesanco, Alvaro; Martínez-Espronceda, Miguel; Serrano, Luis; Chronaki, Catherine E; Escayola, Javier; Martínez, Ignacio; García, José

    2010-11-01

    The ISO/IEEE 11073 (x73) family of standards is a reference frame for medical device interoperability. A draft for an ECG device specialization (ISO/IEEE 11073-10406-d02) has already been presented to the Personal Health Device (PHD) Working Group, and the Standard Communications Protocol for Computer-Assisted ElectroCardioGraphy (SCP-ECG) Standard for short-term diagnostic ECGs (EN1064:2005+A1:2007) has recently been approved as part of the x73 family (ISO 11073-91064:2009). These factors suggest the coordinated use of these two standards in foreseeable telecardiology environments, and hence the need to harmonize them. Such harmonization is the subject of this paper. Thus, a mapping of the mandatory attributes defined in the second draft of the ISO/IEEE 11073-10406-d02 and the minimum SCP-ECG fields is presented, and various other capabilities of the SCP-ECG Standard (such as the messaging part) are also analyzed from an x73-PHD point of view. As a result, this paper addresses and analyzes the implications of some inconsistencies in the coordinated use of these two standards. Finally, a proof-of-concept implementation of the draft x73-PHD ECG device specialization is presented, along with the conversion from x73-PHD to SCP-ECG. This paper, therefore, provides recommendations for future implementations of telecardiology systems that are compliant with both x73-PHD and SCP-ECG.

  10. Study on additional carrier sensing for IEEE 802.15.4 wireless sensor networks.

    PubMed

    Lee, Bih-Hwang; Lai, Ruei-Lung; Wu, Huai-Kuei; Wong, Chi-Ming

    2010-01-01

    Wireless sensor networks based on the IEEE 802.15.4 standard are able to achieve low-power transmissions in the guise of low-rate and short-distance wireless personal area networks (WPANs). The slotted carrier sense multiple access with collision avoidance (CSMA/CA) is used for contention mechanism. Sensor nodes perform a backoff process as soon as the clear channel assessment (CCA) detects a busy channel. In doing so they may neglect the implicit information of the failed CCA detection and further cause the redundant sensing. The blind backoff process in the slotted CSMA/CA will cause lower channel utilization. This paper proposes an additional carrier sensing (ACS) algorithm based on IEEE 802.15.4 to enhance the carrier sensing mechanism for the original slotted CSMA/CA. An analytical Markov chain model is developed to evaluate the performance of the ACS algorithm. Both analytical and simulation results show that the proposed algorithm performs better than IEEE 802.15.4, which in turn significantly improves throughput, average medium access control (MAC) delay and power consumption of CCA detection.

  11. A versatile electrical penetration design qualified to IEEE Std. 317-1983

    SciTech Connect

    Lankenau, W.; Wetherill, T.M.

    1994-12-31

    Although worldwide demand for new construction of nuclear power stations has been on a decline, the available opportunities for the design and construction of qualified electrical penetrations continues to offer challenges, requiring a highly versatile design. Versatility is necessary in order to meet unique customer requirements within the constraints of a design basis qualified to IEEE Std. 317-1983. This paper summarizes such a versatile electrical penetration designed, built and tested to IEEE Std. 317-1983. The principal features are described including major materials of construction. Some of the design constraints such as sealing requirements, and conductor density (including numerical example) are discussed. The requirements for qualification testing of the penetration assembly to IEEE Std. 317-1983 are delineated in a general sense, and some typical test ranges for preconditioning, radiation exposure, and LOCA are provided. The paper concludes by describing ways in which this versatile design has been adapted to meet unique customer requirements in a variety of nuclear power plants.

  12. An IEEE802.15.4-Based System for Locating Children on Their School Commutes

    NASA Astrophysics Data System (ADS)

    Sugiura, Akihiko; Baba, Ryoichi; Kobayashi, Hideyuki

    With the increasing number of crimes and accidents in which children are becoming involved, there is a growing demand for devices to safeguard children's security by detecting their locations on their way to and from school. This paper proposes a system that uses an IEEE802.15.4-standard network to detect children's locations. To overcome the susceptibility of radio interference from nearby wireless LANs, frequency division multiplexing is applied to this IEEE802.15.4-based network, toward improving data acquisition from terminal units. The effectiveness of the system was field-tested with elementary school students who used about 400 IEEE 802.15.4-compliant terminal units. An experiment verified that the use of frequency division multiplexing in an environment where radio interference by wireless LANs is strong allowed the network to double the success rate of information communication from terminal units relative to that without frequency division multiplexing. In the experiment for detecting elementary schoolers' arrival at and departure from school, the terminal detection rate was 99% and the terminal detection rate on the designated school routes was 90%. These results prove the effectiveness of the system in detecting locations.

  13. Sec17 can trigger fusion of trans-SNARE paired membranes without Sec18.

    PubMed

    Zick, Michael; Orr, Amy; Schwartz, Matthew L; Merz, Alexey J; Wickner, William T

    2015-05-05

    Sec17 [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein; α-SNAP] and Sec18 (NSF) perform ATP-dependent disassembly of cis-SNARE complexes, liberating SNAREs for subsequent assembly of trans-complexes for fusion. A mutant of Sec17, with limited ability to stimulate Sec18, still strongly enhanced fusion when ample Sec18 was supplied, suggesting that Sec17 has additional functions. We used fusion reactions where the four SNAREs were initially separate, thus requiring no disassembly by Sec18. With proteoliposomes bearing asymmetrically disposed SNAREs, tethering and trans-SNARE pairing allowed slow fusion. Addition of Sec17 did not affect the levels of trans-SNARE complex but triggered sudden fusion of trans-SNARE paired proteoliposomes. Sec18 did not substitute for Sec17 in triggering fusion, but ADP- or ATPγS-bound Sec18 enhanced this Sec17 function. The extent of the Sec17 effect varied with the lipid headgroup and fatty acyl composition of the proteoliposomes. Two mutants further distinguished the two Sec17 functions: Sec17(L291A,L292A) did not stimulate Sec18 to disassemble cis-SNARE complex but triggered the fusion of trans-SNARE paired membranes. Sec17(F21S,M22S), with diminished apolar character to its hydrophobic loop, fully supported Sec18-mediated SNARE complex disassembly but had lost the capacity to stimulate the fusion of trans-SNARE paired membranes. To model the interactions of SNARE-bound Sec17 with membranes, we show that Sec17, but not Sec17(F21S,M22S), interacted synergistically with the soluble SNARE domains to enable their stable association with liposomes. We propose a model in which Sec17 binds to trans-SNARE complexes, oligomerizes, and inserts apolar loops into the apposed membranes, locally disturbing the lipid bilayer and thereby lowering the energy barrier for fusion.

  14. Sec17 can trigger fusion of trans-SNARE paired membranes without Sec18

    PubMed Central

    Zick, Michael; Orr, Amy; Schwartz, Matthew L.; Merz, Alexey J.; Wickner, William T.

    2015-01-01

    Sec17 [soluble N-ethylmaleimide–sensitive factor (NSF) attachment protein; α-SNAP] and Sec18 (NSF) perform ATP-dependent disassembly of cis-SNARE complexes, liberating SNAREs for subsequent assembly of trans-complexes for fusion. A mutant of Sec17, with limited ability to stimulate Sec18, still strongly enhanced fusion when ample Sec18 was supplied, suggesting that Sec17 has additional functions. We used fusion reactions where the four SNAREs were initially separate, thus requiring no disassembly by Sec18. With proteoliposomes bearing asymmetrically disposed SNAREs, tethering and trans-SNARE pairing allowed slow fusion. Addition of Sec17 did not affect the levels of trans-SNARE complex but triggered sudden fusion of trans-SNARE paired proteoliposomes. Sec18 did not substitute for Sec17 in triggering fusion, but ADP- or ATPγS-bound Sec18 enhanced this Sec17 function. The extent of the Sec17 effect varied with the lipid headgroup and fatty acyl composition of the proteoliposomes. Two mutants further distinguished the two Sec17 functions: Sec17L291A,L292A did not stimulate Sec18 to disassemble cis-SNARE complex but triggered the fusion of trans-SNARE paired membranes. Sec17F21S,M22S, with diminished apolar character to its hydrophobic loop, fully supported Sec18-mediated SNARE complex disassembly but had lost the capacity to stimulate the fusion of trans-SNARE paired membranes. To model the interactions of SNARE-bound Sec17 with membranes, we show that Sec17, but not Sec17F21S,M22S, interacted synergistically with the soluble SNARE domains to enable their stable association with liposomes. We propose a model in which Sec17 binds to trans-SNARE complexes, oligomerizes, and inserts apolar loops into the apposed membranes, locally disturbing the lipid bilayer and thereby lowering the energy barrier for fusion. PMID:25902545

  15. NIH-IEEE 2015 Strategic Conference on Healthcare Innovations and Point-of-Care Technologies for Prec

    Cancer.gov

    NIH and the Institute for Electrical and Electronics Engineering, Engineering in Medicine and Biology Society (IEEE/EMBS) hosted the third iteration of the Healthcare Innovations and Point-of-Care Technologies Conference last week.

  16. Test Methodology for Characterizing the SEE Sensitivity of a Commercial IEEE 1394 Serial Bus (FireWire)

    NASA Technical Reports Server (NTRS)

    Seidleck, C.; Kim, H.; Buchner, S.; Marshall, P. W.; LaBel, K.; Day, John H. (Technical Monitor)

    2002-01-01

    The Single Event Effect (SEE) responses of two FireWire serial buses based on the IEEE 1394 standard were tested with heavy ions and protons. A unique approach to testing and categorizing the SEEs is presented.

  17. THE RESONANT TRANS-NEPTUNIAN POPULATIONS

    SciTech Connect

    Gladman, B.; Lawler, S. M.; Van Laerhoven, C.; Petit, J.-M.; Rousselot, P.; Kavelaars, J.; Jones, R. L.; Parker, J. Wm.; Bieryla, A.; Nicholson, P.; Ashby, M. L. N.

    2012-07-15

    The trans-Neptunian objects (TNOs) trapped in mean-motion resonances with Neptune were likely emplaced there during planet migration late in the giant-planet formation process. We perform detailed modeling of the resonant objects detected in the Canada-France Ecliptic Plane Survey (CFEPS) in order to provide population estimates and, for some resonances, constrain the complex internal orbital element distribution. Detection biases play a critical role because phase relationships with Neptune make object discovery more likely at certain longitudes. This paper discusses the 3:2, 5:2, 2:1, 3:1, 5:1, 4:3, 5:3, 7:3, 5:4, and 7:4 mean-motion resonances, all of which had CFEPS detections, along with our upper limit on 1:1 Neptune Trojans (which is consistent with their small population estimated elsewhere). For the plutinos (TNOs in the 3:2 resonance) we refine the orbital element distribution given by Kavelaars et al. in 2009 and show that steep H-magnitude distributions (N(H){proportional_to}10{sup {alpha}H}, with {alpha} = 0.8-0.9) are favored in the range H{sub g} = 8-9, and confirm that this resonance does not share the inclination distribution of the classical Kuiper Belt. We give the first population estimate for the 5:2 resonance and find that, to within the uncertainties, the population is equal to that of the 3:2 ({approx_equal}13,000 TNOs with H{sub g} < 9.16), whereas the 2:1 population is smaller by a factor of 3-4 compared to the other two resonances. We also measure significant populations inhabiting the 4:3, 5:3, 7:3, 5:4, 7:4, 3:1, and 5:1 resonances, with H{sub g} < 9.16 (D > 100 km) populations in the thousands. We compare our intrinsic population and orbital element distributions with several published models of resonant-TNO production; the most striking discrepancy is that resonances beyond the 2:1 are in reality more heavily populated than in published models.

  18. IEEE Std 730 Software Quality Assurance: Supporting CMMI-DEV v1.3, Product and Process Quality Assurance

    DTIC Science & Technology

    2011-05-27

    TAG to ISO TC 176 Quality Management • Quality : ASQ, work experience • Software: three books, consulting, work experience • Systems: Telecom & DoD... management activities may be assured in accordance with the clauses of ISO 9001 . ©2011 Walz Map Process Areas to P730 Tasks 20 CMMI has several...frameworks 4 CMMI-DEV IEEE / ISO / IEC 15288 / 12207 Quality Assurance ©2011 Walz IEEE Life Cycle Processes & Artifacts • Systems Life Cycle Processes

  19. trans-Bis(hexafluoroantimonato)(phthalocyaninato)copper(II).

    PubMed

    Gardberg, A S; Ibers, J A

    2001-05-01

    The title compound, trans-bis(hexafluoroantimonato-F)(phthalocyaninato-kappa(4)N(29,30,31,32))copper(II), [Cu(SbF(6))(2)(C(32)H(16)N(8))] or Cu(pc)(SbF(6))(2) (pc is phthalocyaninate), comprises a six-coordinate Cu atom, lying on an inversion center, bonded to four N atoms of a phthalocyanine ring and to F atoms of two trans SbF(6)(-) groups. The compound is presumed to consist of a Cu(II) center and a doubly oxidized phthalocyanine ring, by analogy with Cu(pc)(ReO(4))(2).

  20. TransCut: interactive rendering of translucent cutouts.

    PubMed

    Li, Dongping; Sun, Xin; Ren, Zhong; Lin, Stephen; Tong, Yiying; Guo, Baining; Zhou, Kun

    2013-03-01

    We present TransCut, a technique for interactive rendering of translucent objects undergoing fracturing and cutting operations. As the object is fractured or cut open, the user can directly examine and intuitively understand the complex translucent interior, as well as edit material properties through painting on cross sections and recombining the broken pieces—all with immediate and realistic visual feedback. This new mode of interaction with translucent volumes is made possible with two technical contributions. The first is a novel solver for the diffusion equation (DE) over a tetrahedral mesh that produces high-quality results comparable to the state-of-art finite element method (FEM) of Arbree et al. but at substantially higher speeds. This accuracy and efficiency is obtained by computing the discrete divergences of the diffusion equation and constructing the DE matrix using analytic formulas derived for linear finite elements. The second contribution is a multiresolution algorithm to significantly accelerate our DE solver while adapting to the frequent changes in topological structure of dynamic objects. The entire multiresolution DE solver is highly parallel and easily implemented on the GPU. We believe TransCut provides a novel visual effect for heterogeneous translucent objects undergoing fracturing and cutting operations.

  1. TranScreen-N: Method for rapid screening of trans-ungual drug delivery enhancers.

    PubMed

    Murthy, S Narasimha; Vaka, Siva Ram Kiran; Sammeta, Srinivasa Murthy; Nair, Anroop B

    2009-11-01

    Topical monotherapy of nail diseases such as onychomycosis and nail psoriasis has been less successful due to poor permeability of the human nail plate to topically administered drugs. Chemical enhancers are utilized to improve the drug delivery across the nail plate. Choosing the most effective chemical enhancers for the given drug and formulation is highly critical in determining the efficacy of topical therapy of nail diseases. Screening the large pool of enhancers using currently followed diffusion cell experiments would be tedious and expensive. The main objective of this study is to develop TranScreen-N, a high throughput method of screening trans-ungual drug permeation enhancers. It is a rapid microwell plate based method which involves two different treatment procedures; the simultaneous exposure treatment and the sequential exposure treatment. In the present study, several chemicals were evaluated by TranScreen-N and by diffusion studies in the Franz diffusion cell (FDC). Good agreement of in vitro drug delivery data with TranScreen-N data provided validity to the screening technique. In TranScreen-N technique, the enhancers can be grouped according to whether they need to be applied before or simultaneously with drugs (or by either procedures) to enhance the drug delivery across the nail plate. TranScreen-N technique can significantly reduce the cost and duration required to screen trans-ungual drug delivery enhancers.

  2. Diagnosing ALS

    MedlinePlus

    ... that a person diagnosed with ALS seek a second opinion from an ALS "expert" - someone who diagnoses and treats many ALS patients and has training in this medical specialty. The ALS Association maintains a list of recognized experts in the field of ALS. See ALS Association Certified Centers of ...

  3. Biotransformation of trans-1-chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd)

    SciTech Connect

    Schmidt, Tobias; Bertermann, Rüdiger; Rusch, George M.; Tveit, Ann; Dekant, Wolfgang

    2013-05-01

    trans-1-Chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd) is a novel foam blowing and precision cleaning agent with a very low impact for global warming and ozone depletion. trans-HCFO-1233zd also has a low potential for toxicity in rodents and is negative in genotoxicity testing. The biotransformation of trans-HCFO-1233zd and kinetics of metabolite excretion with urine were assessed in vitro and in animals after inhalation exposures. For in vitro characterization, liver microsomes from rats, rabbits and humans were incubated with trans-HCFO-1233zd. Male Sprague Dawley rats and female New Zealand White rabbits were exposed to 2,000, 5,000 and 10,000 ppm for 6 h and urine was collected for 48 h after the end of the exposure. Study specimens were analyzed for metabolites using {sup 19}F NMR, LC-MS/MS and GC/MS. S-(3,3,3-trifluoro-trans-propenyl)-glutathione was identified as predominant metabolite of trans-HCFO-1233zd in all microsomal incubation experiments in the presence of glutathione. Products of the oxidative biotransformation of trans-HCFO-1233zd were only minor metabolites when glutathione was present. In rats, both 3,3,3-trifluorolactic acid and N-acetyl-(3,3,3-trifluoro-trans-propenyl)-L-cysteine were observed as major urinary metabolites. 3,3,3-Trifluorolactic acid was not detected in the urine of rabbits. Quantitation showed rapid excretion of both metabolites in both species (t{sub 1/2} < 6 h) and the extent of biotransformation of trans-HCFO-1233zd was determined as approximately 0.01% of received dose in rabbits and approximately 0.002% in rats. trans-HCFO-1233zd undergoes both oxidative biotransformation and glutathione conjugation at very low rates. The low extent of biotransformation and the rapid excretion of metabolites formed are consistent with the very low potential for toxicity of trans-HCFO-1233zd in mammals. - Highlights: ► No lethality and clinical signs were observed. ► Glutathione S-transferase and cytochrome P-450 dependent

  4. Biotransformation of trans-1-chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd).

    PubMed

    Schmidt, Tobias; Bertermann, Rüdiger; Rusch, George M; Tveit, Ann; Dekant, Wolfgang

    2013-05-01

    trans-1-Chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd) is a novel foam blowing and precision cleaning agent with a very low impact for global warming and ozone depletion. trans-HCFO-1233zd also has a low potential for toxicity in rodents and is negative in genotoxicity testing. The biotransformation of trans-HCFO-1233zd and kinetics of metabolite excretion with urine were assessed in vitro and in animals after inhalation exposures. For in vitro characterization, liver microsomes from rats, rabbits and humans were incubated with trans-HCFO-1233zd. Male Sprague Dawley rats and female New Zealand White rabbits were exposed to 2,000, 5,000 and 10,000ppm for 6h and urine was collected for 48h after the end of the exposure. Study specimens were analyzed for metabolites using (19)F NMR, LC-MS/MS and GC/MS. S-(3,3,3-trifluoro-trans-propenyl)-glutathione was identified as predominant metabolite of trans-HCFO-1233zd in all microsomal incubation experiments in the presence of glutathione. Products of the oxidative biotransformation of trans-HCFO-1233zd were only minor metabolites when glutathione was present. In rats, both 3,3,3-trifluorolactic acid and N-acetyl-(3,3,3-trifluoro-trans-propenyl)-l-cysteine were observed as major urinary metabolites. 3,3,3-Trifluorolactic acid was not detected in the urine of rabbits. Quantitation showed rapid excretion of both metabolites in both species (t1/2<6h) and the extent of biotransformation of trans-HCFO-1233zd was determined as approximately 0.01% of received dose in rabbits and approximately 0.002% in rats. trans-HCFO-1233zd undergoes both oxidative biotransformation and glutathione conjugation at very low rates. The low extent of biotransformation and the rapid excretion of metabolites formed are consistent with the very low potential for toxicity of trans-HCFO-1233zd in mammals.

  5. A note on trans-Planckian tail effects

    SciTech Connect

    Graef, L.L.; Brandenberger, R.

    2015-09-09

    We study the proposal by Mersini et al. http://dx.doi.org/10.1103/PhysRevD.64.043508 that the observed dark energy might be explained by the back-reaction of the set of tail modes in a theory with a dispersion relation in which the mode frequency decays exponentially in the trans-Planckian regime. The matter tail modes are frozen out, however they induce metric fluctuations. The energy-momentum tensor with which the tail modes effect the background geometry obtains contributions from both metric and matter fluctuations. We calculate the equation of state induced by the tail modes taking into account the gravitational contribution. We find that, in contrast to the case of frozen super-Hubble cosmological fluctuations, in this case the matter perturbations dominate, and they yield an equation of state which to leading order takes the form of a positive cosmological constant.

  6. A note on trans-Planckian tail effects

    SciTech Connect

    Graef, L.L.; Brandenberger, R. E-mail: rhb@physics.mcgill.ca

    2015-09-01

    We study the proposal by Mersini et al. [1] that the observed dark energy might be explained by the back-reaction of the set of tail modes in a theory with a dispersion relation in which the mode frequency decays exponentially in the trans-Planckian regime. The matter tail modes are frozen out, however they induce metric fluctuations. The energy-momentum tensor with which the tail modes effect the background geometry obtains contributions from both metric and matter fluctuations. We calculate the equation of state induced by the tail modes taking into account the gravitational contribution. We find that, in contrast to the case of frozen super-Hubble cosmological fluctuations, in this case the matter perturbations dominate, and they yield an equation of state which to leading order takes the form of a positive cosmological constant.

  7. Trans-Aortic Counterpulsation: A Viable Alternative?

    PubMed Central

    Datt, Bharat; Hutchison, Lisa; Peniston, Charles

    2007-01-01

    Abstract: Transthoracic intra-aortic balloon pump (IABP) insertion has been a relatively rare and uncommon procedure. However, it is an established beneficial option in patients with severe peripheral vascular disease (PVD) accompanied with bi-lateral femoral arterial occlusion. There are several viable alternatives to trans-aortic IABP insertion, including trans-axillary or in abdominal aorta (requiring a laparotomy). Cardiac surgery has the advantage of an open sternum, facilitating effortless direct intraaortic balloon (IAB) insertion into the aorta. The IAB can be inserted either through a 9-mm graft or directly into the ascending aorta. During cardiac surgery, direct insertion into the ascending aorta with the balloon tip lying distally in the abdominal aorta is facilitated with an open sternum. The base of the balloon lies ∼2 cm below the left subclavian and can be confirmed through a trans-esophageal echocardiogram (TEE). Elimination of a graft insertion saves the team from time-consuming maneuvers and additional hemorrhagic complications. In our experience, postoperative vasoplegic syndrome coupled with myocardial edema contributed to patent instability and was treated with vasopressin and transthoracic IAB insertion. The CS 100 (Datascope Corp., Mahwah, NJ) console allowed the ability to time the balloon accurately. This case report details our experience with one such patient and establishes trans-aortic counter-pulsation as a safe and viable option in patients with severe PVD, where percutaneous insertion is precluded or has failed. PMID:17672190

  8. Powdered activated carbon adsorption of two fishy odorants in water: Trans,trans-2,4-heptadienal and trans,trans-2,4-decadienal.

    PubMed

    Li, Xin; Wang, Jun; Zhang, Xiaojian; Chen, Chao

    2015-06-01

    Powdered activated carbon (PAC) adsorption of two fishy odorants, trans,trans-2,4-heptadienal (HDE) and trans,trans-2,4-decadienal (DDE), was investigated. Both the pseudo first-order and the pseudo second-order kinetic models well described the kinetics curves, and DDE was more readily removed by PAC. In isotherm tests, both Freundlich and Modified Freundlich isotherms fitted the experimental data well. PAC exhibited a higher adsorption capacity for DDE than for HDE, which could be ascribed to the difference in their hydrophobicity. The calculated thermodynamic parameters (ΔG0, ΔH0, and ΔS0) indicated an exothermic and spontaneous adsorption process. PAC dosage, pH, and natural organic matter (NOM) presence were found to influence the adsorption process. With increasing PAC dosage, the pseudo first-order and pseudo second-order rate constants both increased. The value of pH had little influence on HDE or DDE molecules but altered the surface charge of PAC, and the maximum adsorption capacity occurred at pH9. The presence of NOM, especially the fraction with molecular weight less than 1k Dalton, hindered the adsorption. The study showed that preloaded NOM impaired the adsorption capacity of HDE or DDE more severely than simultaneously fed NOM did.

  9. The Engineered SVA Trans-mobilization Assay.

    PubMed

    Bock, Anja; Schumann, Gerald G

    2016-01-01

    Mammalian genomes harbor autonomous retrotransposons coding for the proteins required for their own mobilization, and nonautonomous retrotransposons, such as the human SVA element, which are transcribed but do not have any coding capacity. Mobilization of nonautonomous retrotransposons depends on the recruitment of the protein machinery encoded by autonomous retrotransposons. Here, we summarize the experimental details of SVA trans-mobilization assays which address multiple questions regarding the biology of both nonautonomous SVA elements and autonomous LINE-1 (L1) retrotransposons. The assay evaluates if and to what extent a noncoding SVA element is mobilized in trans by the L1-encoded protein machinery, the structural organization of the resulting marked de novo insertions, if they mimic endogenous SVA insertions and what the roles of individual domains of the nonautonomous retrotransposon for SVA mobilization are. Furthermore, the highly sensitive trans-mobilization assay can be used to verify the presence of otherwise barely detectable endogenously expressed functional L1 proteins via their marked SVA trans-mobilizing activity.

  10. DoS detection in IEEE 802.11 with the presence of hidden nodes

    PubMed Central

    Soryal, Joseph; Liu, Xijie; Saadawi, Tarek

    2013-01-01

    The paper presents a novel technique to detect Denial of Service (DoS) attacks applied by misbehaving nodes in wireless networks with the presence of hidden nodes employing the widely used IEEE 802.11 Distributed Coordination Function (DCF) protocols described in the IEEE standard [1]. Attacker nodes alter the IEEE 802.11 DCF firmware to illicitly capture the channel via elevating the probability of the average number of packets transmitted successfully using up the bandwidth share of the innocent nodes that follow the protocol standards. We obtained the theoretical network throughput by solving two-dimensional Markov Chain model as described by Bianchi [2], and Liu and Saadawi [3] to determine the channel capacity. We validated the results obtained via the theoretical computations with the results obtained by OPNET simulator [4] to define the baseline for the average attainable throughput in the channel under standard conditions where all nodes follow the standards. The main goal of the DoS attacker is to prevent the innocent nodes from accessing the channel and by capturing the channel’s bandwidth. In addition, the attacker strives to appear as an innocent node that follows the standards. The protocol resides in every node to enable each node to police other nodes in its immediate wireless coverage area. All innocent nodes are able to detect and identify the DoS attacker in its wireless coverage area. We applied the protocol to two Physical Layer technologies: Direct Sequence Spread Spectrum (DSSS) and Frequency Hopping Spread Spectrum (FHSS) and the results are presented to validate the algorithm. PMID:25685510

  11. DoS detection in IEEE 802.11 with the presence of hidden nodes.

    PubMed

    Soryal, Joseph; Liu, Xijie; Saadawi, Tarek

    2014-07-01

    The paper presents a novel technique to detect Denial of Service (DoS) attacks applied by misbehaving nodes in wireless networks with the presence of hidden nodes employing the widely used IEEE 802.11 Distributed Coordination Function (DCF) protocols described in the IEEE standard [1]. Attacker nodes alter the IEEE 802.11 DCF firmware to illicitly capture the channel via elevating the probability of the average number of packets transmitted successfully using up the bandwidth share of the innocent nodes that follow the protocol standards. We obtained the theoretical network throughput by solving two-dimensional Markov Chain model as described by Bianchi [2], and Liu and Saadawi [3] to determine the channel capacity. We validated the results obtained via the theoretical computations with the results obtained by OPNET simulator [4] to define the baseline for the average attainable throughput in the channel under standard conditions where all nodes follow the standards. The main goal of the DoS attacker is to prevent the innocent nodes from accessing the channel and by capturing the channel's bandwidth. In addition, the attacker strives to appear as an innocent node that follows the standards. The protocol resides in every node to enable each node to police other nodes in its immediate wireless coverage area. All innocent nodes are able to detect and identify the DoS attacker in its wireless coverage area. We applied the protocol to two Physical Layer technologies: Direct Sequence Spread Spectrum (DSSS) and Frequency Hopping Spread Spectrum (FHSS) and the results are presented to validate the algorithm.

  12. Impact of electric vehicles on the IEEE 34 node distribution infrastructure

    DOE PAGES

    Jiang, Zeming; Shalalfel, Laith; Beshir, Mohammed J.

    2014-10-01

    With the growing penetration of the electric vehicles to our daily life owing to their economic and environmental benefits, there will be both opportunities and challenges to the utilities when adopting plug-in electric vehicles (PEV) to the distribution network. In this study, a thorough analysis based on real-world project is conducted to evaluate the impacts of electric vehicles infrastructure on the grid relating to system load flow, load factor, and voltage stability. IEEE 34 node test feeder was selected and tested along with different case scenarios utilizing the electrical distribution design (EDD) software to find out the potential impacts tomore » the grid.« less

  13. Suitability of the IEEE 802.15.4e Extensions for Spacecraft and Launcher Communications

    NASA Astrophysics Data System (ADS)

    Dallemagne, Ph.; Decotignie, J.-D.; Piguet, D.; Pelissou, P.; Patte, M.; Dufour, J.-F.

    2014-08-01

    Spacecraft currently use wires to support communication between sensors, controllers and actuators. Replacing the wires by wireless networks is appealing for a number of reasons. This paper presents an analysis of recent extensions to the wireless standard IEEE 802.15.4 as a possible solution to support robust and timely wireless communications inside and between spacecraft. In particular, it shows that with proper tuning and adaptation of the retransmission protocol, it can be used to increase the robustness and determinism of the wireless link.

  14. Impact of electric vehicles on the IEEE 34 node distribution infrastructure

    SciTech Connect

    Jiang, Zeming; Shalalfel, Laith; Beshir, Mohammed J.

    2014-10-01

    With the growing penetration of the electric vehicles to our daily life owing to their economic and environmental benefits, there will be both opportunities and challenges to the utilities when adopting plug-in electric vehicles (PEV) to the distribution network. In this study, a thorough analysis based on real-world project is conducted to evaluate the impacts of electric vehicles infrastructure on the grid relating to system load flow, load factor, and voltage stability. IEEE 34 node test feeder was selected and tested along with different case scenarios utilizing the electrical distribution design (EDD) software to find out the potential impacts to the grid.

  15. Acquisition of Diagnostic Screen and Synchrotron Radiation Images Using IEEE1394 Digital Cameras

    NASA Astrophysics Data System (ADS)

    Rehm, G.

    2004-11-01

    In the LINAC, booster synchrotron and transfer lines of DIAMOND a number of screens (YAG:Ce and OTR) as well as synchrotron radiation ports will be used to acquire information about the transverse beam distribution. Digital IEEE1394 cameras have been selected for their range of sensor sizes and resolutions available, their easy triggering to single events, and their noise-free transmission of the images into the control system. Their suitability for use under influence of high-energy radiation has been verified. Images from preliminary tests at the SRS Daresbury are presented.

  16. Building smart sensor nodes according to IEEE 1451.3 standard.

    PubMed

    da Costa, Murilo N J; Neto, Olegario C S; Ferreira, José O; da Rocha, Adson F; de A Barbosa, Talles M G

    2011-01-01

    A Body Sensor Network (BSN) application requires many software and hardware adaptations to support correctly data exchanges between different sensor node architectures. However, these customizations demand extra time, cost and components. This paper introduces a simple development process in order to customize off-the-shelf BSN sensor nodes according to Transducer Bus Interface Modules (TBIM) standard. IEEE 1451.3 offers technical solutions for interfacing multiple and physically separated transducer allowing self-identification, self-configuration, plug and play and hot swapping capabilities. These are important requirements relating to most BSN applications.

  17. The ac power line protection for an IEEE 587 Class B environment

    NASA Technical Reports Server (NTRS)

    Roehr, W. D.; Clark, O. M.

    1984-01-01

    The 587B series of protectors are unique, low clamping voltage transient suppressors to protect ac-powered equipment from the 6000V peak open-circuit voltage and 3000A short circuit current as defined in IEEE standard 587 for Category B transients. The devices, which incorporate multiple-stage solid-state protector components, were specifically designed to operate under multiple exposures to maximum threat levels in this severe environment. The output voltage peaks are limited to 350V under maximum threat conditions for a 120V ac power line, thus providing adequate protection to vulnerable electronic equipment. The principle of operation and test performance data is discussed.

  18. 76 FR 8726 - EasTrans, LLC; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission EasTrans, LLC; Notice of Filing Take notice that on February 4, 2011, EasTrans, LLC (EasTrans) filed a revised Statement of Operating Conditions (SOC) reflecting...

  19. Quantitative Measurement of Trans-Fats by Infrared Spectroscopy

    ERIC Educational Resources Information Center

    Walker, Edward B.; Davies, Don R.; Campbell, Mike

    2007-01-01

    Trans-fat is a general term, which is mainly used to describe the various trans geometric isomers present in unsaturated fatty acids. Various techniques are now used for a quantitative measurement of the amount of trans-fats present in foods and cooking oil.

  20. ALS Association

    MedlinePlus

    ... toward a world without ALS! Walk to Defeat ALS® Walk to Defeat ALS® draws people of all ... We need your help. I Will Advocate National ALS Registry The National ALS Registry is a congressionally ...

  1. Interoperable and diligent body area networks over IEEE802.15.6 for real-time monitoring.

    PubMed

    Kuroda, Masahiro; Takizawa, Ken-ichi; Kaneda, Isami; Shibata, Yoshiharu; Tochikubo, Osamu

    2011-01-01

    Currently, there are no standardization efforts to define interfaces and verify interoperability among implementations for body area networks (BANs) on IEEE802.15.6. A BAN consists of small and lightweight sensors, such as the ring-type SpO2 sensor, and a coordinator that collects vital data from the sensors and transfers them to a backend system for real-time monitoring and analysis. It is important for sensors to be easy-to-use, light for wearing and that they are long-lived using a small rechargeable battery. IEEE802.15.6 provides basic features for these sensors. We establish an industry-driven standardization association for healthcare/medical services on IEEE802.15.6. Industry standardization targets current and emerging small sensors, not those for fixed medical devices in hospitals, such as those in the ISO/IEEE11073 family, and deals with time-driven data. We propose a combination of various layers of power-saving functions for a sensor that satisfies the interfaces. We discuss these functions and evaluate them. As a feasibility study, we then test a false-alert system using a BAN configuration following the standard interfaces, though the standardizations and evaluations are still in progress along with the IEEE802.15.6 standardization activity.

  2. The Resonant Trans-Neptunian Populations

    NASA Astrophysics Data System (ADS)

    Gladman, B.; Lawler, S. M.; Petit, J.-M.; Kavelaars, J.; Jones, R. L.; Parker, J. Wm.; Van Laerhoven, C.; Nicholson, P.; Rousselot, P.; Bieryla, A.; Ashby, M. L. N.

    2012-07-01

    The trans-Neptunian objects (TNOs) trapped in mean-motion resonances with Neptune were likely emplaced there during planet migration late in the giant-planet formation process. We perform detailed modeling of the resonant objects detected in the Canada-France Ecliptic Plane Survey (CFEPS) in order to provide population estimates and, for some resonances, constrain the complex internal orbital element distribution. Detection biases play a critical role because phase relationships with Neptune make object discovery more likely at certain longitudes. This paper discusses the 3:2, 5:2, 2:1, 3:1, 5:1, 4:3, 5:3, 7:3, 5:4, and 7:4 mean-motion resonances, all of which had CFEPS detections, along with our upper limit on 1:1 Neptune Trojans (which is consistent with their small population estimated elsewhere). For the plutinos (TNOs in the 3:2 resonance) we refine the orbital element distribution given by Kavelaars et al. in 2009 and show that steep H-magnitude distributions (N(H)vprop10αH , with α = 0.8-0.9) are favored in the range Hg = 8-9, and confirm that this resonance does not share the inclination distribution of the classical Kuiper Belt. We give the first population estimate for the 5:2 resonance and find that, to within the uncertainties, the population is equal to that of the 3:2 (sime13,000 TNOs with Hg < 9.16), whereas the 2:1 population is smaller by a factor of 3-4 compared to the other two resonances. We also measure significant populations inhabiting the 4:3, 5:3, 7:3, 5:4, 7:4, 3:1, and 5:1 resonances, with Hg < 9.16 (D > 100 km) populations in the thousands. We compare our intrinsic population and orbital element distributions with several published models of resonant-TNO production; the most striking discrepancy is that resonances beyond the 2:1 are in reality more heavily populated than in published models. Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which

  3. An Efficient Power Saving Mechanism for Delay-Guaranteed Services in IEEE 802.16e

    NASA Astrophysics Data System (ADS)

    Park, Yunju; Hwang, Gang Uk

    As the IEEE 802.16e Wireless Metropolitan Access Network (WMAN) supports the mobility of a mobile station (MS), increasing MS power efficiency has become an important issue. In this paper, we analyze the sleep-mode operation for an efficient power saving mechanism for delay-guaranteed services in the IEEE 802.16e WMAN and observe the effects of the operating parameters related to this operation. For the analysis we use the M/GI/1/K queueing system with multiple vacations, exhaustive services and setup times. In the analysis, we consider the power consumption during the wake-mode period as well as the sleep-mode period. As a performance measure for the power consumption, we propose the power consumption per unit time per effective arrival which considers the power consumption and the packet blocking probability simultaneously. In addition, since we consider delay-guaranteed services, the average packet response delay is also considered as a performance measure. Based on the performance measures, we obtain the optimal sleep-mode operation which minimizes the power consumption per unit time per effective arrival with a given delay requirement. Numerical studies are also provided to investigate the system performance and to show how to achieve our objective.

  4. Software Aspects of IEEE Floating-Point Computations for Numerical Applications in High Energy Physics

    ScienceCinema

    None

    2016-07-12

    Floating-point computations are at the heart of much of the computing done in high energy physics. The correctness, speed and accuracy of these computations are of paramount importance. The lack of any of these characteristics can mean the difference between new, exciting physics and an embarrassing correction. This talk will examine practical aspects of IEEE 754-2008 floating-point arithmetic as encountered in HEP applications. After describing the basic features of IEEE floating-point arithmetic, the presentation will cover: common hardware implementations (SSE, x87) techniques for improving the accuracy of summation, multiplication and data interchange compiler options for gcc and icc affecting floating-point operations hazards to be avoided About the speaker Jeffrey M Arnold is a Senior Software Engineer in the Intel Compiler and Languages group at Intel Corporation. He has been part of the Digital->Compaq->Intel compiler organization for nearly 20 years; part of that time, he worked on both low- and high-level math libraries. Prior to that, he was in the VMS Engineering organization at Digital Equipment Corporation. In the late 1980s, Jeff spent 2½ years at CERN as part of the CERN/Digital Joint Project. In 2008, he returned to CERN to spent 10 weeks working with CERN/openlab. Since that time, he has returned to CERN multiple times to teach at openlab workshops and consult with various LHC experiments. Jeff received his Ph.D. in physics from Case Western Reserve University.

  5. Throughput analysis of the IEEE 802.4 token bus standard under heavy load

    NASA Technical Reports Server (NTRS)

    Pang, Joseph; Tobagi, Fouad

    1987-01-01

    It has become clear in the last few years that there is a trend towards integrated digital services. Parallel to the development of public Integrated Services Digital Network (ISDN) is service integration in the local area (e.g., a campus, a building, an aircraft). The types of services to be integrated depend very much on the specific local environment. However, applications tend to generate data traffic belonging to one of two classes. According to IEEE 802.4 terminology, the first major class of traffic is termed synchronous, such as packetized voice and data generated from other applications with real-time constraints, and the second class is called asynchronous which includes most computer data traffic such as file transfer or facsimile. The IEEE 802.4 token bus protocol which was designed to support both synchronous and asynchronous traffic is examined. The protocol is basically a timer-controlled token bus access scheme. By a suitable choice of the design parameters, it can be shown that access delay is bounded for synchronous traffic. As well, the bandwidth allocated to asynchronous traffic can be controlled. A throughput analysis of the protocol under heavy load with constant channel occupation of synchronous traffic and constant token-passing times is presented.

  6. Investigating the efficiency of IEEE 802.15.4 for medical monitoring applications.

    PubMed

    Pelegris, P; Banitsas, K

    2011-01-01

    Recent advancements in wireless communications technologies bring us one step closer to provide reliable Telecare services as an alternative to patients staying in a hospital mainly for monitoring purposes. In this research we investigate the efficiency of IEEE 802.15.4 in a simple scenario where a patient is being monitored using an ECG and a blood analysis module. This approach binds well with assisted living solutions, by sharing the network infrastructure for both monitoring and control while taking advantage of the low power features of the protocol. Such applications are becoming more and more realistic to implement as IEEE 802.15.4 compatible hardware becomes increasingly available. Our aim is to examine the impact of Beacon and Superframe Order in the medium access delay, dropped packets, end to end delay, average retransmission attempts and consumed power focusing on this bandwidth demanding situation where the network load does not allow low duty cycles, in order to draw some conclusions on the effect that this will have to telemonitoring applications.

  7. Predictable and reliable ECG monitoring over IEEE 802.11 WLANs within a hospital.

    PubMed

    Park, Juyoung; Kang, Kyungtae

    2014-09-01

    Telecardiology provides mobility for patients who require constant electrocardiogram (ECG) monitoring. However, its safety is dependent on the predictability and robustness of data delivery, which must overcome errors in the wireless channel through which the ECG data are transmitted. We report here a framework that can be used to gauge the applicability of IEEE 802.11 wireless local area network (WLAN) technology to ECG monitoring systems in terms of delay constraints and transmission reliability. For this purpose, a medical-grade WLAN architecture achieved predictable delay through the combination of a medium access control mechanism based on the point coordination function provided by IEEE 802.11 and an error control scheme based on Reed-Solomon coding and block interleaving. The size of the jitter buffer needed was determined by this architecture to avoid service dropout caused by buffer underrun, through analysis of variations in transmission delay. Finally, we assessed this architecture in terms of service latency and reliability by modeling the transmission of uncompressed two-lead electrocardiogram data from the MIT-BIH Arrhythmia Database and highlight the applicability of this wireless technology to telecardiology.

  8. Throughput analysis of the IEEE 802.4 token bus standard under heavy load

    NASA Astrophysics Data System (ADS)

    Pang, Joseph; Tobagi, Fouad

    1987-03-01

    It has become clear in the last few years that there is a trend towards integrated digital services. Parallel to the development of public Integrated Services Digital Network (ISDN) is service integration in the local area (e.g., a campus, a building, an aircraft). The types of services to be integrated depend very much on the specific local environment. However, applications tend to generate data traffic belonging to one of two classes. According to IEEE 802.4 terminology, the first major class of traffic is termed synchronous, such as packetized voice and data generated from other applications with real-time constraints, and the second class is called asynchronous which includes most computer data traffic such as file transfer or facsimile. The IEEE 802.4 token bus protocol which was designed to support both synchronous and asynchronous traffic is examined. The protocol is basically a timer-controlled token bus access scheme. By a suitable choice of the design parameters, it can be shown that access delay is bounded for synchronous traffic. As well, the bandwidth allocated to asynchronous traffic can be controlled. A throughput analysis of the protocol under heavy load with constant channel occupation of synchronous traffic and constant token-passing times is presented.

  9. Service design projects sponsored by the Kansas State University Student Chapter of the IEEE EMBS.

    PubMed

    Griffith, Connor; Gruber, Lucinda; Young, Ethan; Humphrey, Jason; Warren, Steve

    2008-01-01

    Service projects offer volunteer student organizations a means to generate interest and focus activity outside of the context of the classroom. This paper addresses efforts by the Kansas State University (KSU) Student Chapter of the IEEE Engineering in Medicine and Biology Society (EMBS) to initiate and guide service projects in two primary areas: (1) research to aid persons with disabilities (RAPD) and (2) hands-on efforts to interest young women in the quantitative fields of science and engineering. Three RAPD projects are presented: a computer mouse design that helps to alleviate productivity problems associated with Parkinson's tremors, a battery removal tool for arthritic individuals with limited dexterity, and a wireless door control and communication system to assist mobility-limited individuals. Service projects to garner science and engineering interest in young women are co-sponsored by the KSU Women in Engineering and Science Program (WESP). The most recent activity, entitled 'Vital Signs Shirts,' is presented in this paper, along with a summary of pending interactive laboratories designed to interest participants in engineering as applied to the human body. These service projects encourage IEEE EMBS student chapter members to explore their biomedical engineering interests and make a positive impact in the community.

  10. Implementing ISO/IEEE 11073: proposal of two different strategic approaches.

    PubMed

    Martínez-Espronceda, M; Serrano, L; Martínez, I; Escayola, J; Led, S; Trigo, J; García, J

    2008-01-01

    This paper explains the challenges encountered during the ISO/IEEE 11073 standard implementation process. The complexity of the standard and the consequent heavy requirements, which have not encouraged software engineers to adopt the standard. The developing complexity evaluation drives us to propose two possible implementation strategies that cover almost all possible use cases and eases handling the standard by non-expert users. The first one is focused on medical devices (MD) and proposes a low-memory and low-processor usage technique. It is based on message patterns that allow simple functions to generate ISO/IEEE 11073 messages and to process them easily. In this way a framework for MDs can be obtained. Second one is focused on more powerful machines such as data loggers or gateways (aka. computer engines (CE)), which do not have the MDs' memory and processor usage constraints. For CEs a more intelligent and adaptative Plug&Play (P&P) solution is provided. It consists on a general platform that can access to any device supported by the standard. Combining both strategies will cut developing time for applications based on ISO/EEE 11073.

  11. On the seamless, harmonized use of ISO/IEEE11073 and openEHR.

    PubMed

    Trigo, Jesús D; Kohl, Christian D; Eguzkiza, Aitor; Martínez-Espronceda, Miguel; Alesanco, Álvaro; Serrano, Luis; García, José; Knaup, Petra

    2014-05-01

    Standardized exchange of clinical information is a key factor in the provision of high quality health care systems. In this context, the openEHR specification facilitates the management of health data in electronic health records (EHRs), while the ISO/IEEE11073 (also referred to as X73PHD) family of standards provides a reference framework for medical device interoperability. Hospitals and health care providers using openEHR require flawless integration of data coming from external sources, such as X73PHD. Hence, a harmonization process is crucial for achieving a seamless, coherent use of those specifications in real scenarios. Such harmonization is the aim of this paper. Thus, the classes and attributes of a representative number of X73PHD specializations for medical devices--weight, temperature, blood pressure, pulse and heart rate, oximetry, and electrocardiograph--along with the X73PHD core document--ISO/IEEE11073-20601--have been analyzed and mapped to openEHR archetypes. The proposed methodology reuses the existing archetypes when possible and suggests new ones--or appropriate modifications--otherwise. As a result, this paper analyzes the inconsistencies found and the implications thereof in the coordinated use of these two standards. The procedure has also shown how existing standards are able to influence the archetype development process, enhancing the existing archetype corpus.

  12. Introduction to Trans Australia Airlines CRM training

    NASA Technical Reports Server (NTRS)

    Davidson, Jim

    1987-01-01

    Trans Australia believes that its excellent accident rate record is due to a number of factors. It has a good group of standard operating procedures, and its crews are pretty well self-disciplined and adhere to those procedures. But the other thing that it believes is a factor in its safety record is that perhaps it is also due to its preparedness to be innovative, to keep up with what is going on in the rest of the world and, if it looks to have value, then to be amongst the first to try it out. Trans Australia commenced a program similar to Line Oriented Flight Training (LOFT) fairly early in 1979--that being its first windshear program-- which leads to why they are doing a course of resource management training, which we have chosen to call Aircrew Team Management (ATM). This course is detailed in another presentation.

  13. Trans fat bans and human freedom.

    PubMed

    Resnik, David

    2010-03-01

    A growing body of evidence has linked consumption of trans fatty acids to cardiovascular disease. To promote public health, numerous state and local governments in the United States have banned the use of artificial trans fats in restaurant foods, and additional bans may follow. Although these policies may have a positive impact on human health, they open the door to excessive government control over food, which could restrict dietary choices, interfere with cultural, ethnic, and religious traditions, and exacerbate socioeconomic inequalities. These slippery slope concerns cannot be dismissed as far-fetched, because the social and political pressures are place to induce additional food regulations. To protect human freedom and other values, policies that significantly restrict food choices, such as bans on types of food, should be adopted only when they are supported by substantial scientific evidence, and when policies that impose fewer restrictions on freedom, such as educational campaigns and product labeling, are likely to be ineffective.

  14. Modeling Trans-Scale Social Processes

    DTIC Science & Technology

    2010-05-01

    Topics • Limits of Empiricism • Radial Concepts • Generic Model of Social Action • Theory Templates – Trans-scale Social Coprocess (TSC) • Orientation...this presentation was supported, in part, by Office of Naval Research, Award No.: N00014-09-1-0766, project Modeling Strategic Contexts. Empiricism ...toward finer-grain, more dynamic models The Need for Social-Theoretical Models • The limits of empiricism – Recognized since Hume – Advances in

  15. Trans-ungual iontophoretic delivery of terbinafine.

    PubMed

    Nair, Anroop B; Vaka, Siva Ram K; Sammeta, Srinivasa M; Kim, Hyun D; Friden, Phillip M; Chakraborty, Bireswar; Murthy, S Narasimha

    2009-05-01

    Successful treatment of deep-seated nail infections remains elusive as the delivery of efficacious levels of antifungal drug to the site of action is very difficult. The aim of the present study was to attain rapid trans-ungual delivery of an antifungal agent, terbinafine, via the topical route using iontophoresis. Initial studies revealed that application of current (0.5 mA/cm(2)) could significantly enhance the trans-ungual delivery of terbinafine. An increase in the applied current or duration of current application enhanced the trans-ungual delivery of terbinafine. Permeation of terbinafine through the nail and drug load in the nail correlated well with the applied electrical dose. Release of drug from nails loaded using iontophoresis followed a two-phase release profile. Light microscopy studies substantiated the capability of iontophoresis to drive a charged molecule across the nail plate. The results of these studies indicate that iontophoresis could be developed as a potential technique for onychomycosis therapy.

  16. A distributed scheme to manage the dynamic coexistence of IEEE 802.15.4-based health-monitoring WBANs.

    PubMed

    Deylami, Mohammad N; Jovanov, Emil

    2014-01-01

    The overlap of transmission ranges between wireless networks as a result of mobility is referred to as dynamic coexistence. The interference caused by coexistence may significantly affect the performance of wireless body area networks (WBANs) where reliability is particularly critical for health monitoring applications. In this paper, we analytically study the effects of dynamic coexistence on the operation of IEEE 802.15.4-based health monitoring WBANs. The current IEEE 802.15.4 standard lacks mechanisms for effectively managing the coexistence of mobile WBANs. Considering the specific characteristics and requirements of health monitoring WBANs, we propose the dynamic coexistence management (DCM) mechanism to make IEEE 802.15.4-based WBANs able to detect and mitigate the harmful effects of coexistence. We assess the effectiveness of this scheme using extensive OPNET simulations. Our results indicate that DCM improves the successful transmission rates of dynamically coexisting WBANs by 20%-25% for typical medical monitoring applications.

  17. PRECISE LABORATORY MEASUREMENTS OF TRANS-DCOOH AND TRANS-HCOOD FOR ASTROPHYSICAL OBSERVATIONS

    SciTech Connect

    Cazzoli, Gabriele; Puzzarini, Cristina; Stopkowicz, Stella; Gauss, Juergen

    2011-09-01

    The rotational spectra of the mono-deuterated isotopologues of trans-formic acid, trans-DCOOH and trans-HCOOD, were investigated. In the millimeter- and submillimeter-wave frequency regions the Lamb-dip technique was exploited to obtain sub-Doppler resolution and to resolve the hyperfine structure due to the deuterium and hydrogen nuclei, thus enabling the accurate determination of the corresponding hyperfine constants. The experimental determination was supported by high-level quantum-chemical calculations at the coupled-cluster level of theory using large atomic-orbital basis sets. The Lamb-dip measurements were also supplemented by THz Doppler-limited measurements in order to extend the predictive capability of the available spectroscopic parameters to higher frequencies.

  18. Custom skiing and trekking adaptations for a trans-tibial and trans-radial quadrilateral amputee.

    PubMed

    Farley, R; Mitchell, F; Griffiths, M

    2004-04-01

    A keen skier who is a trans-tibial and trans-radial quadrilateral amputee sought an improved adaptation for skiing from the Rehabilitation Engineering Service in Edinburgh. The unpredictable nature of the bending moments and loads that can be imposed on the prostheses during skiing raised concern about the suitability of standard prosthetic components for this purpose. The authors report a ski boot modification that incorporates mechanical protection for the standard prosthetic components and a description of the custom-adapted alpine trekking sticks used also as ski poles. Reference is made to the role of risk assessment, the design and manufacture in providing this type of custom-made rehabilitation device.

  19. IEEE/NASA Workshop on Leveraging Applications of Formal Methods, Verification, and Validation

    NASA Technical Reports Server (NTRS)

    Margaria, Tiziana (Editor); Steffen, Bernhard (Editor); Hichey, Michael G.

    2005-01-01

    This volume contains the Preliminary Proceedings of the 2005 IEEE ISoLA Workshop on Leveraging Applications of Formal Methods, Verification, and Validation, with a special track on the theme of Formal Methods in Human and Robotic Space Exploration. The workshop was held on 23-24 September 2005 at the Loyola College Graduate Center, Columbia, MD, USA. The idea behind the Workshop arose from the experience and feedback of ISoLA 2004, the 1st International Symposium on Leveraging Applications of Formal Methods held in Paphos (Cyprus) last October-November. ISoLA 2004 served the need of providing a forum for developers, users, and researchers to discuss issues related to the adoption and use of rigorous tools and methods for the specification, analysis, verification, certification, construction, test, and maintenance of systems from the point of view of their different application domains.

  20. Low-frequency electrical dosimetry: research agenda of the IEEE International Committee on Electromagnetic Safety

    NASA Astrophysics Data System (ADS)

    Reilly, J. Patrick; Hirata, Akimasa

    2016-06-01

    This article treats unsettled issues in the use of numerical models of electrical dosimetry as applied to international limits on human exposure to low-frequency (typically  <  100 kHz) electromagnetic fields and contact current. The perspective in this publication is that of Subcommittee 6 of IEEE-ICES (International Committee on Electromagnetic Safety) Technical Committee 95. The paper discusses 25 issues needing attention, fitting into three general categories: induction models; electrostimulation models; and human exposure limits. Of these, 9 were voted as ‘high priority’ by members of Subcommittee 6. The list is presented as a research agenda for refinements in numerical modeling with applications to human exposure limits. It is likely that such issues are also important in medical and electrical product safety design applications.

  1. vispubdata.org: A Metadata Collection about IEEE Visualization (VIS) Publications.

    PubMed

    Isenberg, Petra; Heimerl, Florian; Koch, Steffen; Isenberg, Tobias; Xu, Panpan; Stolper, Charles; Sedlmair, Michael; Chen, Jian; Moller, Torsten; Stasko, John T

    2016-10-05

    We have created and made available to all a dataset with information about every paper that has appeared at the IEEE Visualization (VIS) set of conferences: InfoVis, SciVis, VAST, and Vis. The information about each paper includes its title, abstract, authors, and citations to other papers in the conference series, among many other attributes. This article describes the motivation for creating the dataset, as well as our process of coalescing and cleaning the data, and a set of three visualizations we created to facilitate exploration of the data. This data is meant to be useful to the broad data visualization community to help understand the evolution of the field and as an example document collection for text data visualization research.

  2. Beamforming transmission in IEEE 802.11ac under time-varying channels.

    PubMed

    Yu, Heejung; Kim, Taejoon

    2014-01-01

    The IEEE 802.11ac wireless local area network (WLAN) standard has adopted beamforming (BF) schemes to improve spectral efficiency and throughput with multiple antennas. To design the transmit beam, a channel sounding process to feedback channel state information (CSI) is required. Due to sounding overhead, throughput increases with the amount of transmit data under static channels. Under practical channel conditions with mobility, however, the mismatch between the transmit beam and the channel at transmission time causes performance loss when transmission duration after channel sounding is too long. When the fading rate, payload size, and operating signal-to-noise ratio are given, the optimal transmission duration (i.e., packet length) can be determined to maximize throughput. The relationship between packet length and throughput is also investigated for single-user and multiuser BF modes.

  3. 2011 IEEE Visualization Contest winner: Visualizing unsteady vortical behavior of a centrifugal pump.

    PubMed

    Otto, Mathias; Kuhn, Alexander; Engelke, Wito; Theisel, Holger

    2012-01-01

    In the 2011 IEEE Visualization Contest, the dataset represented a high-resolution simulation of a centrifugal pump operating below optimal speed. The goal was to find suitable visualization techniques to identify regions of rotating stall that impede the pump's effectiveness. The winning entry split analysis of the pump into three parts based on the pump's functional behavior. It then applied local and integration-based methods to communicate the unsteady flow behavior in different regions of the dataset. This research formed the basis for a comparison of common vortex extractors and more recent methods. In particular, integration-based methods (separation measures, accumulated scalar fields, particle path lines, and advection textures) are well suited to capture the complex time-dependent flow behavior. This video (http://youtu.be/oD7QuabY0oU) shows simulations of unsteady flow in a centrifugal pump.

  4. Development of a low mobility IEEE 802.15.4 compliant VANET system for urban environments.

    PubMed

    Nazabal, Juan Antonio; Falcone, Francisco; Fernández-Valdivielso, Carlos; Matías, Ignacio Raúl

    2013-05-29

    The use of Vehicular Ad-Hoc Networks (VANETs) is growing nowadays and it includes both roadside-to-vehicle communication (RVC) and inter-vehicle communication (IVC). The purpose of VANETs is to exchange useful information between vehicles and the roadside infrastructures for making an intelligent use of them. There are several possible applications for this technology like: emergency warning system for vehicles, cooperative adaptive cruise control or collision avoidance, among others. The objective of this work is to develop a VANET prototype system for urban environments using IEEE 802.15.4 compliant devices. Simulation-based values of the estimated signal strength and radio link quality values are obtained and compared with measurements in outdoor conditions to validate an implemented VANET system. The results confirm the possibility of implementing low cost vehicular communication networks operating at moderate vehicular speeds.

  5. Low-frequency electrical dosimetry: research agenda of the IEEE International Committee on Electromagnetic Safety.

    PubMed

    Reilly, J Patrick; Hirata, Akimasa

    2016-06-21

    This article treats unsettled issues in the use of numerical models of electrical dosimetry as applied to international limits on human exposure to low-frequency (typically  <  100 kHz) electromagnetic fields and contact current. The perspective in this publication is that of Subcommittee 6 of IEEE-ICES (International Committee on Electromagnetic Safety) Technical Committee 95. The paper discusses 25 issues needing attention, fitting into three general categories: induction models; electrostimulation models; and human exposure limits. Of these, 9 were voted as 'high priority' by members of Subcommittee 6. The list is presented as a research agenda for refinements in numerical modeling with applications to human exposure limits. It is likely that such issues are also important in medical and electrical product safety design applications.

  6. IEEE 1394/firewire a low cost, high speed, digital serial bus

    SciTech Connect

    Gaunt, R.

    1997-05-01

    Does the world need yet another 1/0 bus standard? If you need fast and cheap serial video communication, then the answer is yes. As technology advances, so too must data transport mechanisms advance. You can`t expect RS-232 to support real-time digital video, and if you can`t afford expensive professional serial video interfaces, (such as Sony`s Serial Digital Interface), Firewire may be a good solution. IEEE 1394, or commonly known as Firewire, is a general purpose serial bus that meets many of the 1/0 needs of today`s video and multimedia developers. For those of you who only read the first paragraph, here`s Firewire in a nutshell: It provides a guaranteed transfer rate of 10OMbps or 20OMbps of digital data (such as video direct from camera to computer), over an inexpensive, non-proprietary serial bus. Here is a list of its features.

  7. Heterogeneous voice flows-oriented call admission control in IEEE 802.11e WLANs

    NASA Astrophysics Data System (ADS)

    Wu, Qi-lin; Huang, Zhen-jin; Wang, Shi-yi

    2014-04-01

    Considering the circumstance of heterogeneous voice flows, first, by applying Markov chain, this paper proposes an unsaturated analytical model for the IEEE 802.11e EDCA protocol, which considers the condition of non-ideal transmission channel and the character of the occurrence of backoff countdown at the beginning of time slot in EDCA protocol. Furthermore, according to the proposed model, the media access delay and throughput of a flow are analysed, and the flow-oriented call admission control (CAC) scheme is proposed. Finally, the simulation results are shown to confirm that the proposed CAC scheme can guarantee the requirements of throughput and delay of voice flows, and can admit more voice flows to improve the utilisation efficiency of network resources by choosing the appropriate values of the minimum contention window or the appropriate varieties of voice flows.

  8. Development of a Low Mobility IEEE 802.15.4 Compliant VANET System for Urban Environments

    PubMed Central

    Nazabal, Juan Antonio; Falcone, Francisco; Fernández-Valdivielso, Carlos; Matías, Ignacio Raúl

    2013-01-01

    The use of Vehicular Ad-Hoc Networks (VANETs) is growing nowadays and it includes both roadside-to-vehicle communication (RVC) and inter-vehicle communication (IVC). The purpose of VANETs is to exchange useful information between vehicles and the roadside infrastructures for making an intelligent use of them. There are several possible applications for this technology like: emergency warning system for vehicles, cooperative adaptive cruise control or collision avoidance, among others. The objective of this work is to develop a VANET prototype system for urban environments using IEEE 802.15.4 compliant devices. Simulation-based values of the estimated signal strength and radio link quality values are obtained and compared with measurements in outdoor conditions to validate an implemented VANET system. The results confirm the possibility of implementing low cost vehicular communication networks operating at moderate vehicular speeds. PMID:23760089

  9. Integration of heterogeneous biomedical sensors into an ISO/IEEE 11073 compliant application.

    PubMed

    Fioravanti, A; Fico, G; Arredondo, M T; Salvi, D; Villalar, J L

    2010-01-01

    Current trends in healthcare technology include mobile-based applications. Relevant advances in the integration of vital signs monitoring devices with mobile platforms are widely reported nowadays. In this context, conceiving and designing an interoperable application is essential due to the growing necessity of integrating a huge and heterogeneous amount of biomedical data, coming from a wide range of devices and sensors. In this paper the key research issues associated with such integration are presented as well as a specific proposal to solve these problems. It is based on a middleware architecture for the integration of biomedical sensors with mobile devices, derived from the ISO/IEEE 11073 standards family. The application has been developed in the framework of an EU-funded R&D project called METABO.

  10. Fair Scheduling and Throughput Maximization for IEEE 802.16 Mesh Mode Broadband Wireless Access Networks

    NASA Astrophysics Data System (ADS)

    Alam, Muhammad Mahbub; Hamid, Md. Abdul; Razzaque, Md. Abdur; Hong, Choong Seon

    Broadband wireless access networks are promising technology for providing better end user services. For such networks, designing a scheduling algorithm that fairly allocates the available bandwidth to the end users and maximizes the overall network throughput is a challenging task. In this paper, we develop a centralized fair scheduling algorithm for IEEE 802.16 mesh networks that exploits the spatio-temporal bandwidth reuse to further enhance the network throughput. The proposed mechanism reduces the length of a transmission round by increasing the number of non-contending links that can be scheduled simultaneously. We also propose a greedy algorithm that runs in polynomial time. Performance of the proposed algorithms is evaluated by extensive simulations. Results show that our algorithms achieve higher throughput than that of the existing ones and reduce the computational complexity.

  11. A study of IEEE 802.15.4 security framework for wireless body area networks.

    PubMed

    Saleem, Shahnaz; Ullah, Sana; Kwak, Kyung Sup

    2011-01-01

    A Wireless Body Area Network (WBAN) is a collection of low-power and lightweight wireless sensor nodes that are used to monitor the human body functions and the surrounding environment. It supports a number of innovative and interesting applications, including ubiquitous healthcare and Consumer Electronics (CE) applications. Since WBAN nodes are used to collect sensitive (life-critical) information and may operate in hostile environments, they require strict security mechanisms to prevent malicious interaction with the system. In this paper, we first highlight major security requirements and Denial of Service (DoS) attacks in WBAN at Physical, Medium Access Control (MAC), Network, and Transport layers. Then we discuss the IEEE 802.15.4 security framework and identify the security vulnerabilities and major attacks in the context of WBAN. Different types of attacks on the Contention Access Period (CAP) and Contention Free Period (CFP) parts of the superframe are analyzed and discussed. It is observed that a smart attacker can successfully corrupt an increasing number of GTS slots in the CFP period and can considerably affect the Quality of Service (QoS) in WBAN (since most of the data is carried in CFP period). As we increase the number of smart attackers the corrupted GTS slots are eventually increased, which prevents the legitimate nodes to utilize the bandwidth efficiently. This means that the direct adaptation of IEEE 802.15.4 security framework for WBAN is not totally secure for certain WBAN applications. New solutions are required to integrate high level security in WBAN.

  12. Draft 16 of a working document for a proposed standard to be entitled: IEEE standard definitions of terms associated with ferroelectric and related materials.

    PubMed

    2003-12-01

    Prior to acceptance of a standard by IEEE, it is important that the document be widely reviewed by experts in the field. This draft version of the standard is being published here to solicit that input. Readers are encouraged to submit any suggestions or corrections to the IEEE ferroelectrics standards committee for inclusion in the final version.

  13. trans-trans Conjugated linoleic acid enriched soybean oil reduces fatty liver and lowers serum cholesterol in obese zucker rats.

    PubMed

    Gilbert, William; Gadang, Vidya; Proctor, Andrew; Jain, Vishal; Devareddy, Latha

    2011-10-01

    Conjugated linoleic acid (CLA) is a collection of octadecadienoic fatty acids that have been shown to possess numerous health benefits. The CLA used in our study was produced by the photoisomerization of soybean oil and consists of about 20% CLA; this CLA consists of 75% trans-trans (a mixture of t8,t10; t9,t11; t10,t12) isomers. This method could be readily used to increase the CLA content of all soybean oil used as a food ingredient. The objective of this study was to determine the effects of trans-trans CLA-rich soy oil, fed as a dietary supplement, on body composition, dyslipidemia, hepatic steatosis, and markers of glucose control and liver function of obese fa/fa Zucker rats. The trans-trans CLA-rich soy oil lowered the serum cholesterol and low density lipoprotein-cholesterol levels by 41 and 50%, respectively, when compared to obese controls. Trans-trans CLA-rich soy oil supplementation also lowered the liver lipid content significantly (P < 0.05) with a concomitant decrease in the liver weight in the obese rats. In addition, glycated hemoglobin values were improved in the group receiving CLA-enriched soybean oil in comparison to the obese control. PPAR-γ expression in white adipose tissue was unchanged. In conclusion, trans-trans CLA-rich soy oil was effective in lowering total liver lipids and serum cholesterol.

  14. 48 CFR 52.223-16 - IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Environmental Assessment of Personal Computer Products. 52.223-16 Section 52.223-16 Federal Acquisition... Assessment of Personal Computer Products. As prescribed in 23.706(b)(1), insert the following clause: IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products (DEC 2007) (a)...

  15. 48 CFR 52.223-16 - IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Environmental Assessment of Personal Computer Products. 52.223-16 Section 52.223-16 Federal Acquisition... Assessment of Personal Computer Products. As prescribed in 23.705(b)(1), insert the following clause: IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products (DEC 2007) (a)...

  16. 48 CFR 52.223-16 - IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Environmental Assessment of Personal Computer Products. 52.223-16 Section 52.223-16 Federal Acquisition... Assessment of Personal Computer Products. As prescribed in 23.705(b)(1), insert the following clause: IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products (DEC 2007) (a)...

  17. 48 CFR 52.223-16 - IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Environmental Assessment of Personal Computer Products. 52.223-16 Section 52.223-16 Federal Acquisition... Assessment of Personal Computer Products. As prescribed in 23.705(b)(1), insert the following clause: IEEE 1680 Standard for the Environmental Assessment of Personal Computer Products (DEC 2007) (a)...

  18. Architectural and Functional Design and Evaluation of E-Learning VUIS Based on the Proposed IEEE LTSA Reference Model.

    ERIC Educational Resources Information Center

    O'Droma, Mairtin S.; Ganchev, Ivan; McDonnell, Fergal

    2003-01-01

    Presents a comparative analysis from the Institute of Electrical and Electronics Engineers (IEEE) Learning Technology Standards Committee's (LTSC) of the architectural and functional design of e-learning delivery platforms and applications, e-learning course authoring tools, and learning management systems (LMSs), with a view of assessing how…

  19. Analyzing the Engineering Educational Research in Spain: A Global Vision through the Awards of CESEI-IEEE

    ERIC Educational Resources Information Center

    Plaza, I.; Arcega, F.; Castro, M.; Llamas, M.

    2011-01-01

    CESEI is the acronym of the Spanish Chapter of the Education Society of IEEE (the Institute of Electric and Electronics Engineers). Every year, the CESEI awards a prize for the best doctoral thesis and FDP (final (master) degree projects) about education. The thesis or the project must be developed in the areas of electrical engineering,…

  20. An Analysis of IEEE 802.11B and 802.16 Technologies as Part of the Tactical Internet

    DTIC Science & Technology

    2005-09-01

    MANET, MESH, C2PC, C2CE, 802.16, WIMAX, OFDM , COTS, Common Operational Picture, Common Tactical Picture, WLAN, Bridging, Tactical Internet, PRC- 119...19 a. AN/MRC-142 Digital Wideband Transmission System ( DWTS ...63 B. HARRIS CORPORATION’S IEEE 802.11B BASED SECNET-11 PRODUCTS

  1. ALS - resources

    MedlinePlus

    Resources - ALS ... The following organizations are good resources for information on amyotrophic lateral sclerosis : Muscular Dystrophy Association -- www.mda.org/disease/amyotrophic-lateral-sclerosis National Amyotrophic Lateral Sclerosis (ALS) ...

  2. Formation and Migration of Trans-Neptunian Objects

    NASA Technical Reports Server (NTRS)

    Ipatov, S. I.; Oegerle, William (Technical Monitor)

    2002-01-01

    We consider that trans-Neptunian objects (TNOs) with diameter d greater than 100 kilometers moving now in not very eccentric orbits could be formed directly by the compression of large rarefied dust condensations (with a greater than 30 AU), but not by the accretion of smaller solid planetesimals. Probably, some planetesimals with d approximately 100- 1000 kilometers in the feeding zone of the giant planets and even large main-belt asteroids also could be formed directly by such compression. Some smaller objects (TNOs, planetesimals, asteroids) could be debris of larger objects, and other such objects could be formed directly by compression of condensations. A small portion of planetesimals from the feeding zone of the giant planets that entered into the trans-Neptunian region could left in eccentrical orbits beyond Neptune and became so called "scattered objects". Our computer runs in which gravitational interactions of bodies were taken into account with the use of the spheres method, showed that the embryos of Uranus and Neptune could increase their semimajor axes from less than 10 AU to their present values, moving permanently in orbits with small eccentricities, due to gravitational interactions with the migrating planetesimals. Later on, Thommes et al. considered a similar model using direct numerical integration. The total amount of water delivered to the Earth during the formation of the giant, planets was about the mass of water in the Earth oceans. The end of such bombardment could be caused mainly by the planetesimals that became scattered objects. For the present mass of the trans-Neptunian belt, the collisional lifetime of 1-kilometer TNO is about the age of the Solar system, but only a small portion (less than 1%) of 100-km TNOs could be destroyed during this age. The probability of destruction of a typical TNO (with 30 less than a,less than 50 AU) by scattered objects can be of the same order of magnitude as that by typical TNOs. TNOs could be even

  3. Debating trans inclusion in the feminist movement: a trans-positive analysis.

    PubMed

    Green, Eli R

    2006-01-01

    The debate over whether or not to allow, accept, and embrace transpeople as a segment of the feminist movement has been a tumultuous one that remains unresolved. Prominent authors have argued both sides of the dispute. This article analyzes the anti-inclusion feminist viewpoint and offers a trans-positive perspective for moving toward a potential resolution of the debate.

  4. Trans*Forming College Masculinities: Carving out Trans*Masculine Pathways through the Threshold of Dominance

    ERIC Educational Resources Information Center

    Jourian, T. J.

    2017-01-01

    Men and masculinities studies are gaining prominence in higher education literature, illuminating how cisgender college men understand and grapple with masculinity. Additionally, the increased visibility of trans* students has fueled the expanding scholarship and attention to their experiences, often however centering on white gender-conforming…

  5. Perspectives on trans-Pacific biological invasions

    USGS Publications Warehouse

    Guo, Q.

    2002-01-01

    Trans-Pacific biological invasion is one of the most striking and influential biological phenomena occurring in modern times and the process is still accelerating, and the associated invasives form neo-disjuncts (cf. many well-known paleo-disjuncts) between eastern Asia and North America. To better understand this phenomenon and the related taxa, I address the following questions: 1) what types of species (e.g., life/growth form) have been, or are likely to be, associated with trans-Pacific (eastern Asia, North America) invasions; 2) what has happened or may happen to these species after their remote geographic separation, and 3) what aspects of these species and their native and non-native habitats should be better understood for improved control. To answer these questions, comparisons of the invasive species' characteristics in their native and invaded habitats need to be examined, including: l) genetics, 2) life history/morphology (e.g., plant size, seed size, etc.), 3) ecology (e.g., life/growth forms, pollinators, competitors), 4) distributions (e.g., range size, shape, latitude) in their native (source) and introduced (target) ranges or habitats, and 5) physical factors such as soil, water, and climate. The purpose of these studies is 1) to identify the limiting factors that restrict the distributions of exotic species in native ranges, 2) to understand why invasive species are successful in the introduced ranges, 3) to predict possible future invasions, and, ultimately, 4) to provide information for more efficient and effective management.

  6. Analysis of the Rotational Structure in the High-Resolution Infrared Spectra of cis,cis- and trans,trans-1,4-DIFLUOROBUTADIENE-1-d_{1} and trans,trans-1,4-DIFLUOROBUTADIENE-1,4-d_{2}

    NASA Astrophysics Data System (ADS)

    Craig, Norman C.; Chen, Yihui; Lu, Yuhua; Neese, Christopher F.; Nemchick, Deacon J.; Blake, Thomas A.

    2013-06-01

    Samples of cis,cis- and trans,trans-1,4-difluorobutadiene-1-d_{1} (DFBD) and trans,trans-DFBD-1,4-d_{2} have been synthesized and investigated with high-resolution (0.0015 cm^{-1}) infrared spectroscopy. For the first two species the rotational structure in more than one band has been analyzed. For the 1,4-d_{2} species the spectrum of only one C-type band was available in an isotopic mixture. Ground state rotational constants are reported for all three molecules. It is proposed that quartic centrifugal distortion constants computed with a B3LYP/cc-pVTZ model can be used to assess the quality of observed rotational constants. The favorable comparison of predicted and observed ground state rotational constants for all four ^{13}C species of cis,trans-DFBD, which is MW active, demonstrates that the ground state rotational constants for the ^{13}C species of the cis,cis and trans,trans isomers can be successfully predicted with high accuracy. Rotational constants for a full set of isotopologues will be used to determine accurate semiexperimental equilibrium structures of the cis,cis and trans,trans species of DFBD. N. C. Craig, C. M. Oertel, D. C. Oertel, M. J. Tubergen, R. J. Lavrich, A. M Chaka J. Phys. Chem. A 106, 4230-4235 (2002).

  7. Re-visiting the trans insertion model for complexin clamping

    PubMed Central

    Krishnakumar, Shyam S; Li, Feng; Coleman, Jeff; Schauder, Curtis M; Kümmel, Daniel; Pincet, Frederic; Rothman, James E; Reinisch, Karin M

    2015-01-01

    We have previously proposed that complexin cross-links multiple pre-fusion SNARE complexes via a trans interaction to function as a clamp on SNARE-mediated neurotransmitter release. A recent NMR study was unable to detect the trans clamping interaction of complexin and therefore questioned the previous interpretation of the fluorescence resonance energy transfer and isothermal titration calorimetry data on which the trans clamping model was originally based. Here we present new biochemical data that underscore the validity of our previous interpretation and the continued relevancy of the trans insertion model for complexin clamping. DOI: http://dx.doi.org/10.7554/eLife.04463.001 PMID:25831964

  8. Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group (PPWG)

    Cancer.gov

    NCI established the Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group to support development of a comprehensive and interdisciplinary pharmacoepidemiology and pharmacogenomics cancer research program.

  9. Crystallization behavior and texture of trans-containing and trans-free palm oil based confectionery fats.

    PubMed

    De Graef, Veerle; Foubert, Imogen; Smith, Kevin W; Cain, Fred W; Dewettinck, Koen

    2007-12-12

    The objective of this study was to gain insight into the role of trans fatty acids in determining the crystallization behavior and texture of palm-based confectionery fats. Therefore, the isothermal crystallization behavior of two series, each of three fats, one trans-containing and one trans-free, was examined by pNMR, DSC, and rheology. Furthermore, the hardness of these samples was examined at three different storage times at 10 degrees C. All of the trans free samples showed a two-step crystallization at 10 degrees C which is hypothesized to be an alpha-mediated beta' crystallization for two of the samples and a fractionated crystallization in the beta' polymorph for the third, while the trans-containing fats crystallized in a single step, probably a direct beta' crystallization. The trans-containing fat series clearly crystallized faster than the trans-free fat series and also yielded higher hardness values at all storage times investigated. The presence of trans fatty acids seems to reduce the effect of compositional variations on the crystallization process. For the trans free fats, chemical composition was much more critical in determining the crystallization rate, the SFC, and the final hardness value.

  10. [Intake of trans fats; situation in Spain].

    PubMed

    Riobó, Pilar; Breton, Irene

    2014-04-01

    Current nutritional recommendations include decreasing the intake of trans fatty acids (TFA), since there exists sufficient scientific evidence of its influence to cardiovascular disease. During the last decades, in many European countries the TFA intake has considerably decreased through the established legislation and changes in the technological processes developed by the food industry. In Spain, just 2.1 g/day, a 0.7% of the daily energy intake comes from TFA, a lower value than the recommended maximum (<1%), according to data from TRANSFAIR study. The TFA content of processed products such as margarines, factory-baked goods and etc, has declined over recent years and is less than 1% in more than 90% of all these products in Spain. However, it is necessary to develop and implement regulations, governing the TFA content in the products sold in our country, in which there should be the requirement to include this information in the label too.

  11. Wave combustors for trans-atmospheric vehicles

    NASA Technical Reports Server (NTRS)

    Menees, Gene P.; Adelman, Henry G.; Cambier, Jean-Luc; Bowles, Jeffrey V.

    1989-01-01

    The Wave Combustor is an airbreathing hypersonic propulsion system which utilizes shock and detonation waves to enhance fuel-air mixing and combustion in supersonic flow. In this concept, an oblique shock wave in the combustor can act as a flameholder by increasing the pressure and temperature of the air-fuel mixture and thereby decreasing the ignition delay. If the oblique shock is sufficiently strong, then the combustion front and the shock wave can couple into a detonation wave. In this case, combustion occurs almost instantaneously in a thin zone behind the wave front. The result is a shorter, lighter engine compared to the scramjet. This engine, which is called the Oblique Detonation Wave Engine (ODWE), can then be utilized to provide a smaller, lighter vehicle or to provide a higher payload capability for a given vehicle weight. An analysis of the performance of a conceptual trans-atmospheric vehicle powered by an ODWE is given here.

  12. Exploring the Trans-Neptunian Solar System

    NASA Astrophysics Data System (ADS)

    1998-01-01

    A profound question for scientists, philosophers and, indeed, all humans concerns how the solar system originated and subsequently evolved. To understand the solar system's formation, it is necessary to document fully the chemical and physical makeup of its components today, particularly those parts thought to retain clues about primordial conditions and processes.] In the past decade, our knowledge of the outermost, or trans-neptunian, region of the solar system has been transformed as a result of Earth-based observations of the Pluto-Charon system, Voyager 2's encounter with Neptune and its satellite Triton, and recent discoveries of dozens of bodies near to or beyond the orbit of Neptune. As a class, these newly detected objects, along with Pluto, Charon, and Triton, occupy the inner region of a hitherto unexplored component of the solar system, the Kuiper Belt. The Kuiper Belt is believed to be a reservoir of primordial objects of the type that formed in the solar nebula and eventually accreted to form the major planets. The Kuiper Belt is also thought to be the source of short-period comets and a population of icy bodies, the Centaurs, with orbits among the giant planets. Additional components of the distant outer solar system, such as dust and the Oort comet cloud, as well as the planet Neptune itself, are not discussed in this report. Our increasing knowledge of the trans-neptunian solar system has been matched by a corresponding increase in our capabilities for remote and in situ observation of these distant regions. Over the next 10 to 15 years, a new generation of ground- and space-based instruments, including the Keck and Gemini telescopes and the Space Infrared Telescope Facility, will greatly expand our ability to search for and conduct physical and chemical studies on these distant bodies. Over the same time span, a new generation of lightweight spacecraft should become available and enable the first missions designed specifically to explore the icy

  13. Shifting Paradigms: Moving beyond "Trans 101" in Sexuality Education

    ERIC Educational Resources Information Center

    Green, Eli R.

    2010-01-01

    Trans-inclusive sexuality education can be complex, confusing, and outright intimidating for even the most seasoned sexuality educator to teach. Historically, standalone "Trans 101" sessions have successfully raised awareness about the highly marginalized transgender community. However, their potential success has been limited by being taught in…

  14. Trans-mediastinal herniation of bulla: Semilunar sign

    PubMed Central

    Singh, Sheetu; Singh, Nishtha; Singh, Virendra

    2015-01-01

    Trans-mediastinal herniation of lung is seen occasionally but herniation of bulla across the mediastinum is rare. We report two cases with trans-mediastinal herniation of bullae leading to an unusual line appearing near the mediastinum. We propose the name ‘Semilunar sign’for this radiological sign because of its resemblance to the half-moon shape. PMID:26664170

  15. Peptidyl-prolyl cis-trans isomerases: structure and functions.

    PubMed

    Pliyev, B K; Gurvits, B Y

    1999-07-01

    Peptidyl-prolyl cis-trans isomerases (PPI) catalyze cis-trans isomerization of imide bonds in peptides and proteins. This review summarizes the literature on the structure and functions of PPIs, their involvement in protein folding, and organization of PPI-containing receptors and membrane channels. A possible role of several PPIs in distant interactions between cells is discussed.

  16. Trans-Laminar-Reinforced (TLR) Composites

    NASA Technical Reports Server (NTRS)

    Hinders, Mark; Dickinson, Larry

    1997-01-01

    A Trans-Laminar-Reinforced (TLR) composite is defined as composite laminate with up to five percent volume of fibrous reinforcement oriented in a 'trans-laminar' fashion in the through-thickness direction. The TLR can be continuous threads as in 'stitched laminates', or it can be discontinuous rods or pins as in 'Z-Fiber(TM) materials. It has been repeatedly documented in the literature that adding TLR to an otherwise two dimensional laminate results in the following advantages: substantially improved compression-after-impact response; considerably increased fracture toughness in mode 1 (double cantilever beam) and mode 2 (end notch flexure); and severely restricted size and growth of impact damage and edge delamination. TLR has also been used to eliminate catastrophic stiffener disbonding in stiffened structures. TLR directly supports the 'Achilles heel' of laminated composites, that is delamination. As little as one percent volume of TLR significantly alters the mechanical response of laminates. The objective of this work was to characterize the effects of TLR on the in-plane and inter-laminar mechanical response of undamaged composite laminates. Detailed finite element models of 'unit cells', or representative volumes, were used to study the effects of adding TLR on the elastic constants; the in-plane strength; and the initiation of delamination. Parameters investigated included TLR material, TLR volume fraction, TLR diameter, TLR through-thickness angle, ply stacking sequence, and the microstructural features of pure resin regions and curved in-plane fibers. The work was limited to the linear response of undamaged material with at least one ply interface. An inter-laminar dominated problem of practical interest, a flanged skin in bending, was also modeled.

  17. Corrections to "Neural Data-Driven Musculoskeletal Modeling for Personalized Neurorehabilitation Technologies".

    PubMed

    Sartori, Massimo; Lloyd, David G; Farina, Dario

    2016-06-01

    Presents corrections made to author names for the paper, "Neural data-driven musculoskeletal modeling for personalized neurorehabilitation technologies," (Sartori, M., et al) IEEE Trans. Biomed. Eng., vol. 63, no. 5, pp. 879-893, May 2016.

  18. Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products.

    PubMed

    Hurst, W Jeffrey; Glinski, Jan A; Miller, Kenneth B; Apgar, Joan; Davey, Matthew H; Stuart, David A

    2008-09-24

    Dietary resveratrol (3,4',5-trihydroxystilbene) has been implicated in the health benefits associated with grapes and red wine, more specifically with potential benefits for metabolic syndrome, energy use, and increased endurance. Levels of trans-resveratrol and its glucoside, trans-piceid, were determined in 19 top selling commercially available cocoa-containing and chocolate products from the U.S. market. Amounts of trans-resveratrol and trans-piceid were closely correlated with the amount of nonfat cocoa solids (NFCS) in the cocoa-containing products. Among these products, trans-resveratrol levels were highest in cocoa powders (1.85 +/- 0.43 microg/g), followed by unsweetened baking chocolates (1.24 +/- 0.22), semisweet chocolate baking chips (0.52 +/- 0.14), dark chocolates (0.35 +/- 0.08), milk chocolates (0.10 +/- 0.05), and chocolate syrups (0.09 +/- 0.02). These cocoa-containing and chocolate products have about 3-5 times more trans-piceid than trans-resveratrol. Levels of trans-piceid were highest in the cocoa powders (7.14 +/- 0.80 microg/g), followed by unsweetened baking chocolates (4.04 +/- 0.14), semisweet chocolate baking chips (2.01 +/- 0.18), dark chocolates (1.82 +/- 0.36), milk chocolates (0.44 +/- 0.06), and chocolate syrups (0.35 +/- 0.06). On an equal weight basis, cocoa powder had about half as much trans-resveratrol as the average California red wine. On a per serving basis, cocoa-containing and chocolate products had less trans-resveratrol than red wine and grape juice but more than roasted peanuts. Overall, these cocoa-containing and chocolate products rank second after red wines and grape juice in foods with the highest levels of total trans-resveratrol in the diet.

  19. DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)].

    PubMed

    Brabec, Viktor; Christofis, Petros; Slámová, Martina; Kostrhunová, Hana; Nováková, Olga; Najajreh, Yousef; Gibson, Dan; Kaspárková, Jana

    2007-06-15

    A new tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)] with sterically rigid linking group was designed, synthesized and characterized. In this novel molecule, the DNA-binding features of two classes of the platinum compounds with proven antitumor activity are combined, namely trans oriented bifunctional mononuclear platinum complexes with a heterocyclic ligand and polynuclear platinum complexes. DNA-binding mode of this new complex was analyzed by various methods of molecular biology and biophysics. The complex coordinates DNA in a unique way and interstrand and intrastrand cross-links are the predominant lesions formed in DNA in cell-free media and in absence of proteins. An intriguing aspect of trans,trans-[{PtCl2(NH3)}2(piperazine)] is that, using a semi-rigid linker, interstrand cross-linking is diminished relative to other dinuclear platinum complexes with flexible linking groups and lesions that span several base pairs, such as tri- and tetrafunctional adducts, become unlikely. In addition, in contrast to the inability of trans,trans-[{PtCl2(NH3)}2(piperazine)] to cross-link two DNA duplexes, the results of the present work convincingly demonstrate that this dinuclear platinum complex forms specific DNA lesions which can efficiently cross-link proteins to DNA. The results substantiate the view that trans,trans-[{PtCl2(NH3)}2(piperazine)] or its analogues could be used as a tool for studies of DNA properties and their interactions or as a potential antitumor agent. The latter view is also corroborated by the observation that trans,trans-[{PtCl2(NH3)}2(piperazine)] is a more effective cytotoxic agent than cisplatin against human tumor ovarian cell lines.

  20. [Research progress of trans-cinnamaldehyde pharmacological effects].

    PubMed

    Zhang, Li-qing; Zhang, Zhan-gang; Fu, Yan; Xu, Ying

    2015-12-01

    Trans-cinnamaldehyde, the main component of volatile oil from cassia twig or Cinnamomum cassia, which is a traditional Chinese herbal medicine. Trans-cinnamaldehyde is a kind olefine aldehyde of organic compounds and has many pharmacological properties, such as anti-inflammatory, anti-tumor, anti-bacterial, antidiabetic, anti-obesity, and neuroprotection etc. The compound has preventive and therapeutic effects on the nervous system, cardiovascular, cancer, diabetes and other diseases. Trans-cinnamaldehyde, as a preventive care of nature medicine, has great clinical and market potential. This paper gives a review about the pharmacological effects and mechanism of trans-cinnamaldehyde researched in the latest five years. We hope to provide some basic information for further research on trans-cinnamaldehyde.

  1. The linoleic acid and trans fatty acids of margarines.

    PubMed

    Beare-Rogers, J L; Gray, L M; Hollywood, R

    1979-09-01

    Fifty brands of margarine were analysed for cis-polyunsaturated acids by lipoxidase, for trans fatty acid by infared spectroscopy, and for fatty acid composition by gas-liquid chromatography. High concentrations of trans fatty acids tended to be associated with low concentrations of linoleic acid. Later analyses on eight of the brands, respresenting various proportions of linoleic to trans fatty acids, indicated that two of them contained still higher levels of trans fatty acids (greater than 60%) and negligible amounts of linoleic acid. It is proposed that margarine could be a vehicle for the distribution of some dietary linoleic acid and that the level of linoleic acid and the summation of the saturated plus trans fatty acids be known to ascertain nutritional characteristics.

  2. Home healthcare settop-box for senior chronic care using ISO/IEEE 11073 PHD standard.

    PubMed

    Lim, Joon-Ho; Park, Chanyong; Park, Soo-Jun

    2010-01-01

    As the number of seniors with chronic disease increases, the need of home healthcare settop-box is increased to manage their chronic disease in their home environment. Using the home healthcare settop-box, the patients can regularly check their health data, and finally, it can lead the decrease of medical expenses. For the home healthcare settop-box, the most important factor is the standard compatibility, which can interoperate with standard devices of any other companies. In this paper, we propose a home healthcare settop-box using ISO/IEEE 11073 PHD standard. It collects health data according to the PHD standard, and provides a chronic-care service based on the collected data. The proposed settop-box is connected with 3 devices of weigh scale, blood pressure monitor, and glucose meter, and tested at 10 homes for a month. Lastly, the proposed settop-box can be used for various healthcare services such as Google Health and Telemedicine Services using a healthcare platform server.

  3. Link Investigation of IEEE 802.15.4 Wireless Sensor Networks in Forests

    PubMed Central

    Ding, Xingjian; Sun, Guodong; Yang, Gaoxiang; Shang, Xinna

    2016-01-01

    Wireless sensor networks are expected to automatically monitor the ecological evolution and wildlife habits in forests. Low-power links (transceivers) are often adopted in wireless sensor network applications, in order to save the precious sensor energy and then achieve long-term, unattended monitoring. Recent research has presented some performance characteristics of such low-power wireless links under laboratory or outdoor scenarios with less obstacles, and they have found that low-power wireless links are unreliable and prone to be affected by the target environment. However, there is still less understanding about how well the low-power wireless link performs in real-world forests and to what extent the complex in-forest surrounding environments affect the link performances. In this paper, we empirically evaluate the low-power links of wireless sensors in three typical different forest environments. Our experiment investigates the performance of the link layer compatible with the IEEE 802.15.4 standard and analyzes the variation patterns of the packet reception ratio (PRR), the received signal strength indicator (RSSI) and the link quality indicator (LQI) under diverse experimental settings. Some observations of this study are inconsistent with or even contradict prior results that are achieved in open fields or relatively clean environments and thus, provide new insights both into effectively evaluating the low-power wireless links and into efficiently deploying wireless sensor network systems in forest environments. PMID:27355957

  4. On the Feasibility of Wireless Multimedia Sensor Networks over IEEE 802.15.5 Mesh Topologies

    PubMed Central

    Garcia-Sanchez, Antonio-Javier; Losilla, Fernando; Rodenas-Herraiz, David; Cruz-Martinez, Felipe; Garcia-Sanchez, Felipe

    2016-01-01

    Wireless Multimedia Sensor Networks (WMSNs) are a special type of Wireless Sensor Network (WSN) where large amounts of multimedia data are transmitted over networks composed of low power devices. Hierarchical routing protocols typically used in WSNs for multi-path communication tend to overload nodes located within radio communication range of the data collection unit or data sink. The battery life of these nodes is therefore reduced considerably, requiring frequent battery replacement work to extend the operational life of the WSN system. In a wireless sensor network with mesh topology, any node may act as a forwarder node, thereby enabling multiple routing paths toward any other node or collection unit. In addition, mesh topologies have proven advantages, such as data transmission reliability, network robustness against node failures, and potential reduction in energy consumption. This work studies the feasibility of implementing WMSNs in mesh topologies and their limitations by means of exhaustive computer simulation experiments. To this end, a module developed for the Synchronous Energy Saving (SES) mode of the IEEE 802.15.5 mesh standard has been integrated with multimedia tools to thoroughly test video sequences encoded using H.264 in mesh networks. PMID:27164106

  5. Low-power secure body area network for vital sensors toward IEEE802.15.6.

    PubMed

    Kuroda, Masahiro; Qiu, Shuye; Tochikubo, Osamu

    2009-01-01

    Many healthcare/medical services have started using personal area networks, such as Bluetooth and ZigBee; these networks consist of various types of vital sensors. These works focus on generalized functions for sensor networks that expect enough battery capacity and low-power CPU/RF (Radio Frequency) modules, but less attention to easy-to-use privacy protection. In this paper, we propose a commercially-deployable secure body area network (S-BAN) with reduced computational burden on a real sensor that has limited RAM/ROM sizes and CPU/RF power consumption under a light-weight battery. Our proposed S-BAN provides vital data ordering among sensors that are involved in an S-BAN and also provides low-power networking with zero-administration security by automatic private key generation. We design and implement the power-efficient media access control (MAC) with resource-constraint security in sensors. Then, we evaluate the power efficiency of the S-BAN consisting of small sensors, such as an accessory type ECG and ring-type SpO2. The evaluation of power efficiency of the S-BAN using real sensors convinces us in deploying S-BAN and will also help us in providing feedbacks to the IEEE802.15.6 MAC, which will be the standard for BANs.

  6. On the Feasibility of Wireless Multimedia Sensor Networks over IEEE 802.15.5 Mesh Topologies.

    PubMed

    Garcia-Sanchez, Antonio-Javier; Losilla, Fernando; Rodenas-Herraiz, David; Cruz-Martinez, Felipe; Garcia-Sanchez, Felipe

    2016-05-05

    Wireless Multimedia Sensor Networks (WMSNs) are a special type of Wireless Sensor Network (WSN) where large amounts of multimedia data are transmitted over networks composed of low power devices. Hierarchical routing protocols typically used in WSNs for multi-path communication tend to overload nodes located within radio communication range of the data collection unit or data sink. The battery life of these nodes is therefore reduced considerably, requiring frequent battery replacement work to extend the operational life of the WSN system. In a wireless sensor network with mesh topology, any node may act as a forwarder node, thereby enabling multiple routing paths toward any other node or collection unit. In addition, mesh topologies have proven advantages, such as data transmission reliability, network robustness against node failures, and potential reduction in energy consumption. This work studies the feasibility of implementing WMSNs in mesh topologies and their limitations by means of exhaustive computer simulation experiments. To this end, a module developed for the Synchronous Energy Saving (SES) mode of the IEEE 802.15.5 mesh standard has been integrated with multimedia tools to thoroughly test video sequences encoded using H.264 in mesh networks.

  7. New IEEE 11073 Standards for interoperable, networked Point-of-Care Medical Devices.

    PubMed

    Kasparick, Martin; Schlichting, Stefan; Golatowski, Frank; Timmermann, Dirk

    2015-08-01

    Surgical procedures become more and more complex and the number of medical devices in an operating room (OR) increases continuously. Today's vendor-dependent solutions for integrated ORs are not able to handle this complexity. They can only form isolated solutions. Furthermore, high costs are a result of vendor-dependent approaches. Thus we present a service-oriented device communication for distributed medical systems that enables the integration and interconnection between medical devices among each other and to (medical) information systems, including plug-and-play functionality. This system will improve patient's safety by making technical complexity of a comprehensive integration manageable. It will be available as open standards that are part of the IEEE 11073 family of standards. The solution consists of a service-oriented communication technology, the so called Medical Devices Profile for Web Services (MDPWS), a Domain Information & Service Model, and a binding between the first two mechanisms. A proof of this concept has been done with demonstrators of real world OR devices.

  8. An SNMP-based solution to enable remote ISO/IEEE 11073 technical management.

    PubMed

    Lasierra, Nelia; Alesanco, Alvaro; García, José

    2012-07-01

    This paper presents the design and implementation of an architecture based on the integration of simple network management protocol version 3 (SNMPv3) and the standard ISO/IEEE 11073 (X73) to manage technical information in home-based telemonitoring scenarios. This architecture includes the development of an SNMPv3-proxyX73 agent which comprises a management information base (MIB) module adapted to X73. In the proposed scenario, medical devices (MDs) send information to a concentrator device [designated as compute engine (CE)] using the X73 standard. This information together with extra information collected in the CE is stored in the developed MIB. Finally, the information collected is available for remote access via SNMP connection. Moreover, alarms and events can be configured by an external manager in order to provide warnings of irregularities in the MDs' technical performance evaluation. This proposed SNMPv3 agent provides a solution to integrate and unify technical device management in home-based telemonitoring scenarios fully adapted to X73.

  9. ISO/IEEE 11073 PHD message generation toolkit to standardize healthcare device.

    PubMed

    Lim, Joon-Ho; Park, Chanyong; Park, Soo-Jun; Lee, Kyu-Chul

    2011-01-01

    As senior population increases, various healthcare devices and services are developed such as fall detection device, home hypertension management service, and etc. However, to vitalize healthcare devices and services market, standardization for interoperability between device and service must precede. To achieve the standardization goal, the IEEE 11073 Personal Health Device (PHD) group has been standardized many healthcare devices, but until now there are few devices compatible with the PHD standard. One of main reasons is that it isn't easy for device manufactures to implement standard communication module by analyzing standard documents of over 600 pages. In this paper, we propose a standard message generation toolkit to easily standardize existing non-standard healthcare devices. The proposed toolkit generates standard PHD messages using inputted device information, and the generated messages are adapted to the device with the standard state machine file. For the experiments, we develop a reference H/W, and test the proposed toolkit with three healthcare devices: blood pressure, weighting scale, and glucose meter. The proposed toolkit has an advantage that even if the user doesn't know the standard in detail, the user can easily standardize the non-standard healthcare devices.

  10. Link Investigation of IEEE 802.15.4 Wireless Sensor Networks in Forests.

    PubMed

    Ding, Xingjian; Sun, Guodong; Yang, Gaoxiang; Shang, Xinna

    2016-06-27

    Wireless sensor networks are expected to automatically monitor the ecological evolution and wildlife habits in forests. Low-power links (transceivers) are often adopted in wireless sensor network applications, in order to save the precious sensor energy and then achieve long-term, unattended monitoring. Recent research has presented some performance characteristics of such low-power wireless links under laboratory or outdoor scenarios with less obstacles, and they have found that low-power wireless links are unreliable and prone to be affected by the target environment. However, there is still less understanding about how well the low-power wireless link performs in real-world forests and to what extent the complex in-forest surrounding environments affect the link performances. In this paper, we empirically evaluate the low-power links of wireless sensors in three typical different forest environments. Our experiment investigates the performance of the link layer compatible with the IEEE 802.15.4 standard and analyzes the variation patterns of the packet reception ratio (PRR), the received signal strength indicator (RSSI) and the link quality indicator (LQI) under diverse experimental settings. Some observations of this study are inconsistent with or even contradict prior results that are achieved in open fields or relatively clean environments and thus, provide new insights both into effectively evaluating the low-power wireless links and into efficiently deploying wireless sensor network systems in forest environments.

  11. IEEE-802.15.4-based low-power body sensor node with RF energy harvester.

    PubMed

    Tran, Thang Viet; Chung, Wan-Young

    2014-01-01

    This paper proposes the design and implementation of a low-voltage and low-power body sensor node based on the IEEE 802.15.4 standard to collect electrocardiography (ECG) and photoplethysmography (PPG) signals. To achieve compact size, low supply voltage, and low power consumption, the proposed platform is integrated into a ZigBee mote, which contains a DC-DC booster, a PPG sensor interface module, and an ECG front-end circuit that has ultra-low current consumption. The input voltage of the proposed node is very low and has a wide range, from 0.65 V to 3.3 V. An RF energy harvester is also designed to charge the battery during the working mode or standby mode of the node. The power consumption of the proposed node reaches 14 mW in working mode to prolong the battery lifetime. The software is supported by the nesC language under the TinyOS environment, which enables the proposed node to be easily configured to function as an individual health monitoring node or a node in a wireless body sensor network (BSN). The proposed node is used to set up a wireless BSN that can simultaneously collect ECG and PPG signals and monitor the results on the personal computer.

  12. IEEE 802.16 Packet Scheduling with Traffic Prioritization and Cross-Layer Optimization

    NASA Astrophysics Data System (ADS)

    Monteiro, João; Sargento, Susana; Gomes, Álvaro; Fontes, Francisco; Neves, Pedro

    WiMAX is emerging as a broadband wireless access technology to satisfy end user expectations, containing a new set of advantages in terms of throughput, coverage and QoS support at the MAC level which allows convergence of several different types of applications and services. For that reason, the allocation of resources or scheduling becomes of greater importance. This paper focuses on a cross-layer scheduling optimization solution for IEEE 802.16. The relevant features of the proposed packet scheduling optimization scheme consist: of prioritization of users within the same traffic class, allowing for example to an operator, differentiated treatment among users, for instance distinguishing between premium or gold users and silver users; and also cross layer optimization which implies radio resource optimization and a more effective scheduler decision. Simulation scenarios are presented to demonstrate how the scheduling solution allocates resources through particular WiMAX MAC layer implementation in the NS-2 simulator. Results show that the new mechanism implementation results in an improvement to the simple Round Robin fashion present in the original simulation model, being able to increase differentiation between different classes and decrease packets delay, due to its cross-layer processing and traffic prioritization.

  13. Experiences and lessons learned from the formation of a new IEEE EMBS student chapter.

    PubMed

    Celebi, Leyla; Pickel, Lara; Sprouse, Mary; Dyer, Stephen A; Warren, Steve

    2006-01-01

    A student chapter of a professional society offers many benefits to faculty and students, as it presents a means whereby students can become engaged with a global community in their areas of training prior to graduation from their local institution. This paper addresses the experiences and lessons learned from the Fall 2005 formation of a student chapter of the IEEE Engineering in Medicine and Biology Society (EMBS) at Kansas State University (KSU). Since KSU does not currently support a formal biomedical engineering program, the overall goal of this endeavor was to establish an organization that could serve as a focal community for both ongoing and future biomedical efforts. Initial chapter activities targeted fund raising and the establishment of project teams whose goal is to design products to aid persons with disabilities. Successes include very rapid growth in numbers of participants, excitement that the students and local community express with regard to the design projects, and the broad diversity, in terms of both gender and area of study, of those participating. Lessons learned center on constitutional issues and the administration of the student design projects.

  14. An enhanced reservation-based MAC protocol for IEEE 802.15.4 networks.

    PubMed

    Afonso, José A; Silva, Helder D; Macedo, Pedro; Rocha, Luis A

    2011-01-01

    The IEEE 802.15.4 Medium Access Control (MAC) protocol is an enabling standard for wireless sensor networks. In order to support applications requiring dedicated bandwidth or bounded delay, it provides a reservation-based scheme named Guaranteed Time Slot (GTS). However, the GTS scheme presents some drawbacks, such as inefficient bandwidth utilization and support to a maximum of only seven devices. This paper presents eLPRT (enhanced Low Power Real Time), a new reservation-based MAC protocol that introduces several performance enhancing features in comparison to the GTS scheme. This MAC protocol builds on top of LPRT (Low Power Real Time) and includes various mechanisms designed to increase data transmission reliability against channel errors, improve bandwidth utilization and increase the number of supported devices. A motion capture system based on inertial and magnetic sensors has been used to validate the protocol. The effectiveness of the performance enhancements introduced by each of the new features is demonstrated through the provision of both simulation and experimental results.

  15. Adaptive RTS threshold for maximum network throughput in IEEE 802.11 DCF

    NASA Astrophysics Data System (ADS)

    Yan, Shaohu; Zhuo, Yongning; Wu, Shiqi; Guo, Wei

    2004-04-01

    The IEEE 802.11 medium access control (MAC) protocol provides shared access to wireless channel. Its primary MAC technique is called distributed coordination function (DCF) that includes two packet transmission schemes, namely, basic access and RTS/CTS access mechanisms. In a "hybrid" network combining the two schemes, packets with payload longer than a given threshold (RTS Threshold) are transmitted according to the RTS/CTS mechanism. Based on delicate mathematical model, the average time in a successful and unsuccessful transmission is analyzed in the assumption of idea channel. Then the relation of network saturation throughput and RTS threshold was found and expressed in theoretical formula. We present the numerical techniques to find out the optimum RTS threshold that can maximize the network capacity. An adaptive RTS threshold adjust algorithm (ARTA), with which a station can automatically adjust its RTS threshold to the current optimum value, is also presented in detail. A special procedure is also developed to help ARTA in determination of station numbers. All theoretical analysis and algorithm are validated through computer simulation.

  16. trans-Dichloridobis[dicyclo­hex­yl(phen­yl)phosphane-κP]palladium(II)

    PubMed Central

    Burgoyne, Andrew R.; Meijboom, Reinout; Ogutu, Hezron

    2012-01-01

    The title compound, [PdCl2{P(C6H11)2(C6H5)}2], forms a monomeric complex with a trans-square-planar geometry. The Pd—P bond lengths are 2.3343 (5) Å, as the Pd atom lies on an inversion centre, while the Pd—Cl bond lengths are 2.3017 (4) Å. The observed structure was found to be closely related to [PdCl2{P(C6H11)3}2] [Grushin et al. (1994 ▶). Inorg. Chem. 33, 4804–4806], [PdBr2{P(C6H11)3}2] [Clarke et al. (2003 ▶). Dalton Trans. pp. 4393–4394] and [PdCl2P(C6H11)2(C7H7)}2] [Vuoti et al. (2008 ▶). Eur. J. Inorg. Chem. pp. 397–407] (C6H11 is cyclo­hexyl and C7H7 is o-tol­yl). One of the cyclo­hexyl rings is disordered with the phenyl ring in a 0.587 (9):413 (9) ratio. Five long-range C—H⋯Cl inter­actions were observed within the structure. PMID:22589787

  17. Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group.

    PubMed

    Eckel, Robert H; Borra, Susan; Lichtenstein, Alice H; Yin-Piazza, Shirley Y

    2007-04-24

    A 2-day forum was convened to discuss the current status and future implications of reducing trans fatty acids without increasing saturated fats in the food supply while maintaining functionality and consumer acceptance of packaged, processed, and prepared foods. Attendees represented the agriculture and oilseed industry and oil processing, food manufacturing, food service, government, food technology, and health and nutrition disciplines. Presentations included food science behind fatty acid technology, the health science of dietary fatty acids, alternatives to trans fatty acids, and the use of alternatives in food manufacturing and food service. The reduction of trans fatty acids in the food supply is a complex issue involving interdependent and interrelated stakeholders. Actions to reduce trans fatty acids need to carefully consider both intended and unintended consequences related to nutrition and public health. The unintended consequence of greatest concern is that fats and oils high in saturated fats, instead of the healthier unsaturated fats, might be used to replace fats and oils with trans fatty acids. Many different options of alternative oils and fats to replace trans fatty acids are available or in development. Decisions on the use of these alternatives need to consider availability, health effects, research and development investments, reformulated food quality and taste, supply-chain management, operational modifications, consumer acceptance, and cost. The conference demonstrated the value of collaboration between the food industry and health and nutrition professionals, and this conference model should be used to address other food development, processing, and/or technology issues.

  18. Design and implementation of an IEEE 802.11 baseband OFDM transceiver in 0.18 μm CMOS

    NASA Astrophysics Data System (ADS)

    Bin, Wu; Yumei, Zhou; Yongxu, Zhu; Zhengdong, Zhang; Jingjing, Cai

    2011-05-01

    An SISO IEEE 802.11 baseband OFDM transceiver ASIC is implemented. The chip can support all of the SISO IEEE 802.11 work modes by optimizing the key module and sharing the module between the transmitter and receiver. The area and power are decreased greatly compared with other designs. The baseband prototype has been verified under the WLAN baseband test equipment and through transferring the video. The 0.18 μm 1P/6M CMOS technology layout is finished and the chip is fabricated in SMIC, which occupies a 2.6 × 2.6 mm2 area and consumes 83 mW under typical work modes.

  19. Performance Analysis of IEEE 802.11g Waveform Transmitted Over a Fading Channel with Pulse-Noise Interference

    DTIC Science & Technology

    2006-06-01

    transmitted over a slow, flat fading Nakagami channel for AWGN only, as well as for AWGN plus pulse-noise interference. The implementation of forward...noise power. 15. NUMBER OF PAGES 123 14. SUBJECT TERMS IEEE 802.11g WLAN Standard, Nakagami Fading Channel, OFDM, Soft Decision Decoding, Pulse...their performance with Viterbi soft decision decoding when the signal was transmitted over a slow, flat fading Nakagami channel for additive white

  20. Error detecting capabilities of the shortened Hamming codes adopted for error detection in IEEE Standard 802.3

    NASA Technical Reports Server (NTRS)

    Fujiwara, Toru; Kasami, Tadao; Lin, Shu

    1989-01-01

    The error-detecting capabilities of the shortened Hamming codes adopted for error detection in IEEE Standard 802.3 are investigated. These codes are also used for error detection in the data link layer of the Ethernet, a local area network. The weight distributions for various code lengths are calculated to obtain the probability of undetectable error and that of detectable error for a binary symmetric channel with bit-error rate between 0.00001 and 1/2.

  1. Introduction to the special issue on the 2011 Joint IEEE International Frequency Control Symposium and European Frequency and Time Forum.

    PubMed

    Burt, Eric; Gill, Patrick

    2012-03-01

    The 8 invited and 17 contributed papers in this special issue focus on the following topical areas covered at the 2011 Joint IEEE International Frequency Control Symposium and European Frequency and Time Forum, held in San Francisco, California: 1) Materials and Resonators; 2) Oscillators, Synthesizers, and Noise; 3) Microwave Frequency Standards; 4) Sensors and Transducers; 5) Timekeeping and Time and Frequency Transfer; and 6) Optical Frequency Standards.

  2. Dynamic subframe allocation for mobile broadband m-health using IEEE 802.16j mobile multihop relay networks.

    PubMed

    Alinejad, Ali; Istepanian, R S H; Philip, N

    2012-01-01

    The concept of 4G health will be one of the key focus areas of future m-health research and enterprise activities in the coming years. WiMAX technology is one of the constituent 4G wireless technologies that provides broadband wireless access (BWA). Despite the fact that WiMAX is able to provide a high data rate in a relatively large coverage; this technology has specific limitations such as: coverage, signal attenuation problems due to shadowing or path loss, and limited available spectrum. The IEEE 802.16j mobile multihop relay (MMR) technology is a pragmatic solution designed to overcome these limitations. The aim of IEEE 802.16j MMR is to expand the IEEE 802.16e's capabilities with multihop features. In particular, the uplink (UL) and downlink (DL) subframe allocation in WiMAX network is usually fixed. However, dynamic frame allocation is a useful mechanism to optimize uplink and downlink subframe size dynamically based on the traffic conditions through real-time traffic monitoring. This particular mechanism is important for future WiMAX based m-health applications as it allows the tradeoff in both UL and DL channels. In this paper, we address the dynamic frame allocation issue in IEEE 802.16j MMR network for m-health applications. A comparative performance analysis of the proposed approach is validated using the OPNET Modeler(®). The simulation results have shown an improved performance of resource allocation and end-to-end delay performance for typical medical video streaming application.

  3. Pathways of trans,trans-muconaldehyde metabolism in mouse liver cytosol: reversibility of monoreductive metabolism and formation of end products.

    PubMed

    Zhang, Z; Kline, S A; Kirley, T A; Goldstein, B D; Witz, G

    1993-01-01

    The metabolism of trans,trans-muconaldehyde (MUC), a hematotoxic agent which is a presumed in vivo metabolite of benzene, was studied in mouse liver cytosol. MUC was incubated for 30 min at 37 degrees C with mouse liver cytosol (from CD-1 mice) supplemented with NAD+ and the products were analyzed by reverse phase HPLC. Two products were detected in addition to the previously identified acid-aldehyde 6-oxo-trans,trans-2,4-hexadienoic acid (COOH-M-CHO) and the diacid trans,trans-muconic acid (COOH-M-COOH). Based on the molecular weight (112) obtained by thermo-spray LC-mass spectrometry and the absorbance maximum (269 nm), one of the products was identified as the aldehyde-alcohol 6-hydroxy-trans,trans-2,4-hexadienal (CHO-M-OH). The second product was identified as 6-hydroxy-trans,trans-2,4-hexadienoic acid (COOH-M-OH) by coelution with authentic standard, the fragmentation pattern obtained by electron impact mass spectrometry and the absorbance maximum (258 nm). Time course and concentration dependency studies indicate that COOH-M-OH and COOH-M-COOH are end products of MUC metabolism while CHO-M-OH, and COOH-M-CHO, the initially formed mono-reduction and mono-oxidation products, respectively, are the intermediates leading to these end products. The metabolite COOH-M-OH is formed mainly by oxidation of CHO-M-OH and to a much lesser extent by reduction of CHO-M-COOH, whereas COOH-M-COOH is formed solely by oxidation of COOH-M-CHO. The reduction of MUC to CHO-M-OH is reversible, whereas oxidation to COOH-M-CHO is not. The compound CHO-M-OH is not only oxidized to COOH-M-OH by oxidation of the aldehyde functional group, but is also converted back to MUC by oxidation of the alcohol functional group.

  4. Phase Transition in all-trans-β-Carotene Crystal: Temperature-Dependent Raman Spectra.

    PubMed

    da Silva, Kleber J R; Paschoal, Waldomiro; Belo, Ezequiel A; Moreira, Sanclayton G C

    2015-09-24

    In this study, we studied the stability of an all-trans-β-carotene single crystal using Raman spectroscopy with line excitation at 632.8 nm, in the temperature range 20–300 K. The Raman spectra exhibit clear modifications in the spectral range of the lattice and internal vibrational modes. The temperature dependence of the most intense vibrational modes ν1 (1511 cm(–1)) and ν2 (1156 cm(–1)) that are related to the C═C and C—C stretching vibrations of the polyene chain, respectively, shows an upward shift on the Raman modes. This behavior is similar to that stated in the theoretical work of Wei-Long Liu et al. We conclude that the all-trans-β-carotene crystal undergoes a temperature-induced phase transition at approximately 219 K. This transition is interpreted as a rotation experienced by β-ring groups at each end of the all-trans-β-carotene molecule around the dihedral angle. At low temperatures, the new molecular configuration affects the sliding plane of the space group C2h(5)(P2(1)/n), and the phase transition leads to an unchanged monoclinic structure; however, the original space group is possibly lowered to the space group C2. In the temperature range 200–220 K, the spectral ratio (S) of the integrated intensities of the spectral modes around the symmetric and asymmetric stretching wavenumbers of the methyl group (CH3) changes as a function of temperature in agreement with the phase transition. Furthermore, according to phase transition undergone by the all-trans-β-carotene, the thermal results obtained by differential scanning calorimetry show an exothermic process that occurs near the transition temperature assigned by the Raman spectra.

  5. Service Differentiated and Adaptive CSMA/CA over IEEE 802.15.4 for Cyber-Physical Systems

    PubMed Central

    Gao, Ruixia

    2013-01-01

    Cyber-Physical Systems (CPS) that collect, exchange, manage information, and coordinate actions are an integral part of the Smart Grid. In addition, Quality of Service (QoS) provisioning in CPS, especially in the wireless sensor/actuator networks, plays an essential role in Smart Grid applications. IEEE 802.15.4, which is one of the most widely used communication protocols in this area, still needs to be improved to meet multiple QoS requirements. This is because IEEE 802.15.4 slotted Carrier Sense Multiple Access/Collision Avoidance (CSMA/CA) employs static parameter configuration without supporting differentiated services and network self-adaptivity. To address this issue, this paper proposes a priority-based Service Differentiated and Adaptive CSMA/CA (SDA-CSMA/CA) algorithm to provide differentiated QoS for various Smart Grid applications as well as dynamically initialize backoff exponent according to traffic conditions. Simulation results demonstrate that the proposed SDA-CSMA/CA scheme significantly outperforms the IEEE 802.15.4 slotted CSMA/CA in terms of effective data rate, packet loss rate, and average delay. PMID:24260021

  6. Service differentiated and adaptive CSMA/CA over IEEE 802.15.4 for Cyber-Physical Systems.

    PubMed

    Xia, Feng; Li, Jie; Hao, Ruonan; Kong, Xiangjie; Gao, Ruixia

    2013-01-01

    Cyber-Physical Systems (CPS) that collect, exchange, manage information, and coordinate actions are an integral part of the Smart Grid. In addition, Quality of Service (QoS) provisioning in CPS, especially in the wireless sensor/actuator networks, plays an essential role in Smart Grid applications. IEEE 802.15.4, which is one of the most widely used communication protocols in this area, still needs to be improved to meet multiple QoS requirements. This is because IEEE 802.15.4 slotted Carrier Sense Multiple Access/Collision Avoidance (CSMA/CA) employs static parameter configuration without supporting differentiated services and network self-adaptivity. To address this issue, this paper proposes a priority-based Service Differentiated and Adaptive CSMA/CA (SDA-CSMA/CA) algorithm to provide differentiated QoS for various Smart Grid applications as well as dynamically initialize backoff exponent according to traffic conditions. Simulation results demonstrate that the proposed SDA-CSMA/CA scheme significantly outperforms the IEEE 802.15.4 slotted CSMA/CA in terms of effective data rate, packet loss rate, and average delay.

  7. Performance Analysis of IEEE 802.15.6 CSMA/CA Protocol for WBAN Medical Scenario through DTMC Model.

    PubMed

    Kumar, Vivek; Gupta, Bharat

    2016-12-01

    The newly drafted IEEE 802.15.6 standard for Wireless Body Area Networks (WBAN) has been concentrating on a numerous medical and non-medical applications. Such short range wireless communication standard offers ultra-low power consumption with variable data rates from few Kbps to Mbps in, on or around the proximity of the human body. In this paper, the performance analysis of carrier sense multiple access with collision avoidance (CSMA/CA) scheme based on IEEE 802.15.6 standard in terms of throughput, reliability, clear channel assessment (CCA) failure probability, packet drop probability, and end-to-end delay has been presented. We have developed a discrete-time Markov chain (DTMC) to significantly evaluate the performances of IEEE 802.15.6 CSMA/CA under non-ideal channel condition having saturated traffic condition including node wait time and service time. We also visualize that, as soon as the payload length increases the CCA failure probability increases, which results in lower node's reliability. Also, we have calculated the end-to-end delay in order to prioritize the node wait time cause by backoff and retransmission. The user priority (UP) wise DTMC analysis has been performed to show the importance of the standard especially for medical scenario.

  8. Trans-laminar-reinforced (TLR) composites

    NASA Astrophysics Data System (ADS)

    Dickinson, Larry Charles

    1997-11-01

    A Trans-Laminar-Reinforced (TLR) composite is defined as composite laminate with up to five percent volume of fibrous reinforcement oriented in a "trans-laminar" fashion in the through-thickness direction. The TLR can be continuous threads as in "stitched laminates", or it can be discontinuous rods or pins as in "Z-FiberspTM" materials. Adding TLR to an otherwise two dimensional laminate results in the following advantages: substantially improved compression-after-impact response; considerably increased fracture toughness in mode I (double cantilever beam) and mode II (end notch flexure); and severely restricted size and growth of impact damage and edge delamination. TLR has also been used to eliminate catastrophic stiffener disbonding in stiffened structures. As little as one percent volume of TLR significantly alters the mechanical response of laminates. The objective of this work was to characterize the effects of TLR on the in-plane and inter-laminar mechanical response of undamaged composite laminates. Detailed finite element models were made of "unit cells," or representative volumes, and an inter-laminar dominated problem of practical interest. The work was limited to the linear response of undamaged material with at least one ply interface. Adding a few percent TLR had a small negative effect on the in-plane extensional and shear moduli, Esbx, Esby and Gsbxy, but had a large positive effect (up to 60 percent) on the thickness direction extensional modulus, Esbz. The out-of-plane shear moduli, Gsbxz and Gsbyz, were significantly affected only with the use of a TLR with a shear modulus an order of magnitude greater than that of the composite lamina. A simple stiffness averaging method for calculating the elastic constants was found to compare closely with the finite element results, with the greatest difference being found in the inter-laminar shear moduli, Gsbxz and Gsbyz. Delamination initiation was studied with a strength of materials approach in the unit

  9. Efficacy of trans-cinnamaldehyde against Psoroptes cuniculi in vitro.

    PubMed

    Shen, Fengge; Xing, Mingxun; Liu, Lihui; Tang, Xudong; Wang, Wei; Wang, Xiaohong; Wu, Xiuping; Wang, Xuelin; Wang, Xinrui; Wang, Guangming; Zhang, Junhui; Li, Lei; Zhang, Jiyu; Yu, Lu

    2012-04-01

    The acaricidal activity of trans-cinnamaldehyde was evaluated in vitro on Psoroptes cuniculi. In this study, different concentrations of trans-cinnamaldehyde were tested, and the observed mites mortality was compared with that observed in untreated and treated (Acacerulen R®) controls. The morphological changes in P. cuniculi treated with trans-cinnamaldehyde were examined with light microscopy. By the analysis of variance one-way test, up to 8 μg/ml of trans-cinnamaldehyde gave highly significant (P < 0.01) percentages of mite mortality compared with the untreated controls, but only up to 256 μg/ml, it showed the same efficacy of Acacerulen R®. At the same time, a bioassay was conducted by exposing mites to varying doses of trans-cinnamaldehyde in vitro cultures. The resulting data were analyzed by using a time-dose-mortality modeling technique, yielding the parameters for time and dose effects of P. cuniculi. The β value was 2.01, indicating that trans-cinnamaldehyde had a good activity to kill P. cuniculi adults. Based on the time-dose-mortality relationships fitted and the virulence indices estimated, trans-cinnamaldehyde is a promising microbial agent for mites control.

  10. Evolutionary Insights into RNA trans-Splicing in Vertebrates

    PubMed Central

    Lei, Quan; Li, Cong; Zuo, Zhixiang; Huang, Chunhua; Cheng, Hanhua; Zhou, Rongjia

    2016-01-01

    Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which may exert a function distinct from its original molecules. Trans-spliced RNAs may encode novel proteins or serve as noncoding or regulatory RNAs. These novel RNAs not only increase the complexity of the proteome but also provide new regulatory mechanisms for gene expression. An increasing amount of evidence indicates that trans-splicing occurs frequently in both physiological and pathological processes. In addition, mRNA reprogramming based on trans-splicing has been successfully applied in RNA-based therapies for human genetic diseases. Nevertheless, clarifying the extent and evolution of trans-splicing in vertebrates and developing detection methods for trans-splicing remain challenging. In this review, we summarize previous research, highlight recent advances in trans-splicing, and discuss possible splicing mechanisms and functions from an evolutionary viewpoint. PMID:26966239

  11. Evolutionary Insights into RNA trans-Splicing in Vertebrates.

    PubMed

    Lei, Quan; Li, Cong; Zuo, Zhixiang; Huang, Chunhua; Cheng, Hanhua; Zhou, Rongjia

    2016-03-10

    Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which may exert a function distinct from its original molecules. Trans-spliced RNAs may encode novel proteins or serve as noncoding or regulatory RNAs. These novel RNAs not only increase the complexity of the proteome but also provide new regulatory mechanisms for gene expression. An increasing amount of evidence indicates that trans-splicing occurs frequently in both physiological and pathological processes. In addition, mRNA reprogramming based on trans-splicing has been successfully applied in RNA-based therapies for human genetic diseases. Nevertheless, clarifying the extent and evolution of trans-splicing in vertebrates and developing detection methods for trans-splicing remain challenging. In this review, we summarize previous research, highlight recent advances in trans-splicing, and discuss possible splicing mechanisms and functions from an evolutionary viewpoint.

  12. Guaranteeing QoE in Audio-Video Transmission by IEEE 802.11e HCCA

    NASA Astrophysics Data System (ADS)

    Noh, Zul Azri Bin Muhamad; Suzuki, Takahiro; Tasaka, Shuji

    This paper studies packet scheduling schemes with QoE (user-level QoS) guarantee for audio-video transmission in a wireless LAN with HCF controlled channel access (HCCA) of the IEEE 802.11e MAC protocol. We first propose the static scheduling (SS) scheme, which grants adjustable transmission opportunity (TXOP) duration for constant bit rate (CBR) traffic. The SS scheme can determine the minimum TXOP duration capable of guaranteeing high QoE; it can maximize the number of admitted flows. As the burstiness of variable bit rate (VBR) traffic cannot be absorbed by the SS scheme, we also propose the multimedia priority dynamic scheduling (MPDS) scheme, which can absorb the burstiness through allocating additional TXOP duration. We then compare the SS scheme, the MPDS scheme, and the reference scheduler (TGe scheme) in terms of application-level QoS and user-level QoS (QoE). Numerical results show that in the SS scheme, the QoE can be kept relatively higher even when the TXOP duration is reduced in the case of video with the I picture pattern; this implies that more flows can be admitted. In the case of video with the IPPPPP picture pattern, which has the VBR characteristic more remarkably, reducing the TXOP duration according to the SS scheme will deteriorate the QoS level. In this case, the MPDS scheme performs better when the number of multimedia stations is small. However, the performance of the MPDS scheme deteriorates with the increase of the number of multimedia stations, though the results are comparable to or even better than those of the SS and TGe schemes.

  13. Influence of trans fatty acids on health.

    PubMed

    Stender, Steen; Dyerberg, Jørn

    2004-01-01

    The contribution of dietary trans fatty acids (TFAs) on the risk of ischemic heart disease (IHD) has recently gained further support due to the results from large, prospective, population-based studies. Compared to saturated fat, TFAs are, gram to gram, associated with a considerably (2.5- to >10-fold) higher risk increment for IHD. A negative effect on the human fetus and on newborns and an increase in colon cancer risk in adults are possible but, however, still equivocal. Recent findings justify further studies concerning the effect of TFAs on allergic diseases in children and on the risk of type-2 diabetes in adults. The intake of industrially produced TFAs in European countries is decreasing. However, determination of the TFA content in various popular food items collected in Danish shops showed that it is likely that persons with a frequent intake of, e.g., French fries, microwave oven popcorn, chocolate bars, fast food, etc., consume industrially produced TFAs in amounts far exceeding the average intake, and are thereby exposed to an unnecessary health risk. The Danish government has decided that oils and fats containing more than 2% industrially produced TFAs will not be sold in Denmark after the January 1, 2004.

  14. Electron attachment to trans-azobenzene.

    PubMed

    Modelli, Alberto; Burrow, Paul D

    2009-10-14

    The temporary anion states of gas-phase trans-azobenzene are characterised by means of electron transmission spectroscopy (ETS) in the 0-6 eV range. The measured energies of vertical electron attachment are compared with the energies of the pi* virtual orbitals of the neutral molecule supplied by HF (at MP2 optimized geometries) and B3LYP calculations. The calculated energies, scaled with empirical equations, reproduce quantitatively the energies of the corresponding spectral features and predict a positive vertical electron affinity of 0.83 eV. The total anion current at the walls of the collision chamber and the mass-selected molecular anion current are also reported as a function of the impact electron energy. In agreement with previous data, long-lived (>1 mus) parent molecular anions are detected at zero eV and near 1 eV. The close similarity of the electron transmission spectrum with the derivatives with respect to energy of the anion currents suggests strongly that shape resonances produced by electron capture into empty pi* orbitals are the initial step in formation of the long lived molecular anions. This appears to rule out mechanisms in which direct formation of core-excited anion states are invoked. However, according to DFT calculations, conversion of the shape resonances around 1 eV to longer-lived sigma-pi* core-excited doublet anion states is possible on energetic grounds.

  15. Proceedings of the IEEE International Workshop on Safety of Systems (1st) held in Monterey, California on 15-16 Mar 2007

    DTIC Science & Technology

    2007-03-01

    Programming: Concurrency Page 36© 2005 by Andrew Kornecki and Janusz Zalewski • An informal scan of the real-time (embedded, dedicated, safety...Press, pp. 40-47. 8. R. Sterritt, D.F. Bantz, “PAC-MEN: Personal Autonomic Computing Monitoring Environments,” In Proceedings of IEEE DEXA 2004...Autonomic Computing Environment,” In Proceedings of IEEE DEXA 2003 Workshops - 1st International Workshop on Autonomic Computing Systems, Prague, Czech

  16. Robotic trans-atrial and trans-mitral ventricular septal resection

    PubMed Central

    2017-01-01

    Localized ventricular septal hypertrophy, also known as idiopathic hypertrophic subaortic stenosis or idiopathic hypertrophic subaortic septal obstruction (IHSS), can create severe ventricular outflow obstruction. This often results in a high sub-aortic pressure gradient with potentially lethal symptoms. In 1960, Braunwald described the hemodynamic characteristics of IHSS, and thereafter, Morrow developed a trans-aortic approach to resect a large part of the ventricular septum, enlarging the outflow tract. The Morrow operation has remained the gold standard for surgically treating this pathology. However, in patients with a small aortic annulus, a severely hypertrophied septum, and a long anterior mitral leaflet, the trans-aortic approach may be more difficult, resulting in an inadequate resection and/or systolic anterior leaflet motion. The latter usually increases the obstruction and can cause mitral regurgitation. Herein, we describe a minimally invasive trans-left atrial robotic approach to treat IHSS. First, the anterior mitral leaflet is incised radially to reveal the aortic outflow tract and ventricular septum, which are located posteriorly. Thereafter, a deep “block” of septum is excised, beginning at the right valve cusp nadir and continued counterclockwise toward the left fibrous trigone. This excision is extended to the anterior papillary muscle base, where any septal connections must be divided. Subsequently, the anterior leaflet is re-suspended and the repair is completed with a flexible annuloplasty band. If necessary, the anterior leaflet can be augmented with a pericardial patch. The “wristed” robotic instruments and magnified 3-D vision definitely facilitate an adequate septal resection and anterior papillary muscle mobilization. Moreover, it is possible that this fine control helps to reduce complications, such as heart block or a ventricular septal defect. PMID:28203542

  17. Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate.

    PubMed

    Vernooij, Robbin R; Joshi, Tanmaya; Shaili, Evyenia; Kubeil, Manja; Appadoo, Dominique R T; Izgorodina, Ekaterina I; Graham, Bim; Sadler, Peter J; Wood, Bayden R; Spiccia, Leone

    2016-06-20

    We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR- and Raman-active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid- and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.

  18. Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate

    PubMed Central

    2016-01-01

    We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR- and Raman-active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid- and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules. PMID:27257848

  19. The cis-isomer performs better than the trans-isomer in porphyrin-sensitized solar cells: interfacial electron transport and charge recombination investigations.

    PubMed

    Luo, Liyang; Ambre, Ram B; Mane, Sandeep B; Diau, Eric Wei-Guang; Hung, Chen-Hsiung

    2015-08-21

    We report characterizations and device performance for dye-sensitized solar cells using cis- and trans-isomers of 2D-π-2A zinc porphyrins with carboxyphenyl and thienyl groups in their meso-positions. Under identical experimental conditions with similar dye loadings, we observed overall power conversion efficiencies of 2.44% and 0.88% for devices made of cis-2S2A and trans-2S2A, respectively. This uneven performance among cis and trans isomers under the same experimental conditions can be rationalized with detailed investigations via spectroscopic, quantum chemical, and femtosecond fluorescence up-conversion investigations. Density functional theory (DFT) calculations show that a small amount of electron density is localized over carboxyphenyl groups in the LUMO of cis-2S2A, but there is no electron density populated on the carboxyphenyl groups in the LUMO of trans-2S2A. The femtosecond fluorescence decay measurements revealed that the excited-state lifetime of trans-2S2A on Al2O3 is half of that of cis-2S2A on Al2O3. Moreover, the dye-to-TiO2 electron injection time of trans-2S2A is 2.54 ps, which is shorter than that of cis-2S2A/TiO2 (2.95 ps). Electrochemical impedance spectra measured under one sun illumination also revealed that the charge recombination time of cis-2S2A is longer than that of trans-2S2A. This thorough understanding of isomeric effects on the performance of porphyrins will serve as a guideline for the design of future sensitizing dyes for solar cells.

  20. The metabolism of cis- and trans-decalin

    PubMed Central

    Elliott, T. H.; Robertson, J. S.; Williams, R. T.

    1966-01-01

    1. The metabolism of cis- and trans-decalin in the rabbit has been investigated. 2. Both hydrocarbons were oxidized to racemic secondary alcohols and excreted as ether glucuronides in amounts equal to about 60% of the dose administered. The principal glucuronides were isolated as triacetyl methyl esters and as sodium salts. 3. cis-Decalin gave rise mainly to (±)-cis–cis-2-decalol, together with a little cis–trans-2-decalol, and trans-decalin mainly to (±)-trans–cis-2-decalol and a small amount of trans–trans-2-decalol. 4. These results suggest that biological oxidation of the decalins does not occur via a free-radical mechanism. An attempt is made to explain why racemic alcohols are obtained, rather than the more typical optically active products of enzymic reaction, and a mechanism is proposed. It is suggested that enzymes similar to steroid hydroxylases are involved. PMID:5968538

  1. Analysis of the rotational structure in the high-resolution infrared spectra of cis,cis- and trans,trans-1,4-difluorobutadiene-1-d1 and trans,trans-1,4-difluorobutadiene-1,4-d2

    SciTech Connect

    Craig, Norman C.; Chen, Yihui; Lu, Yuhua; Neese, Christopher F.; Nemchick, Deacon J.; Blake, Thomas A.

    2013-06-01

    Samples of cis,cis- and trans,trans-1,4-difluorobutadiene-1- d1 and of trans,trans-1,4-difluorobutadiene-1,4-d2 have been synthesized, and high-resolution (≤0.0018 cm-1) infrared spectra of these substances have been recorded in the gas phase. Analysis of the rotational structure, mostly in C-type bands, has yielded ground state rotational constants. For the two 1-d1 species more than one band has been analyzed. For the 1,4-d2 species only one band was available for analysis. However, good agreement between the experimental centrifugal distortion constants and those predicted with a B3LYP/cc-pVTZ model give strong support to the analysis of the very dense spectrum. The ground state rotational constants are a contribution to finding semiexperimental equilibrium structures of the two nonpolar isomers of 1,4- difluorobutadiene.

  2. Trans-fatty acids and cardiovascular risk: does origin matter?

    PubMed

    Dawczynski, Christine; Lorkowski, Stefan

    2016-09-01

    Several studies have aimed to unravel the contribution of different types of dietary fatty acids to human health and disease. Investigations have consistently shown that high consumption of industrially produced trans-fatty acids from partially hydrogenated vegetable oils is harmful to human health, in particular cardiovascular health. Therefore, the U.S. Food and Drug Administration announced that partially hydrogenated oils are no longer 'generally recognized as safe', and trans-fatty acids are not permitted in the U.S. food supply. On the other hand, recent studies analyzing the association between circulating trans-fatty acids and disease have revealed that some ruminant-specific trans-fatty acids are associated with a reduction in incidence of disease. In this special report, we highlight recent findings and point out perspectives for future studies on this topic.

  3. Trans-cis molecular photoswitching in interstellar Space.

    PubMed

    Cuadrado, S; Goicoechea, J R; Roncero, O; Aguado, A; Tercero, B; Cernicharo, J

    2016-12-01

    As many organic molecules, formic acid (HCOOH) has two conformers (trans and cis). The energy barrier to internal conversion from trans to cis is much higher than the thermal energy available in molecular clouds. Thus, only the most stable conformer (trans) is expected to exist in detectable amounts. We report the first interstellar detection of cis-HCOOH. Its presence in ultraviolet (UV) irradiated gas exclusively (the Orion Bar photodissociation region), with a low trans-to-cis abundance ratio of 2.8 ± 1.0, supports a photoswitching mechanism: a given conformer absorbs a stellar photon that radiatively excites the molecule to electronic states above the interconversion barrier. Subsequent fluorescent decay leaves the molecule in a different conformer form. This mechanism, which we specifically study with ab initio quantum calculations, was not considered in Space before but likely induces structural changes of a variety of interstellar molecules submitted to UV radiation.

  4. Trans-cis molecular photoswitching in interstellar Space*

    PubMed Central

    Cuadrado, S.; Goicoechea, J. R.; Roncero, O.; Aguado, A.; Tercero, B.; Cernicharo, J.

    2016-01-01

    As many organic molecules, formic acid (HCOOH) has two conformers (trans and cis). The energy barrier to internal conversion from trans to cis is much higher than the thermal energy available in molecular clouds. Thus, only the most stable conformer (trans) is expected to exist in detectable amounts. We report the first interstellar detection of cis-HCOOH. Its presence in ultraviolet (UV) irradiated gas exclusively (the Orion Bar photodissociation region), with a low trans-to-cis abundance ratio of 2.8 ± 1.0, supports a photoswitching mechanism: a given conformer absorbs a stellar photon that radiatively excites the molecule to electronic states above the interconversion barrier. Subsequent fluorescent decay leaves the molecule in a different conformer form. This mechanism, which we specifically study with ab initio quantum calculations, was not considered in Space before but likely induces structural changes of a variety of interstellar molecules submitted to UV radiation. PMID:28003686

  5. Harassment Patterns and Risk Profile in Spanish Trans Persons.

    PubMed

    Devís-Devís, José; Pereira-García, Sofía; Valencia-Peris, Alexandra; Fuentes-Miguel, Jorge; López-Cañada, Elena; Pérez-Samaniego, Víctor

    2017-01-01

    This article describes the harassment patterns and the risk profile in trans people living in Spain. A sample of 212 trans persons, aged 10-62, participated in this cross-sectional study. Results showed a high percentage of harassment (59.9%) and frequency of daily harassment (12.6%), especially verbal attacks (59%) that occurred in public spaces (49.1%) and within educational contexts (46.2%). Harassment is more prevalent in trans women than men. Those who disclose their gender identities at a younger age experience higher percentages and frequency of harassment than those who disclose at an older age. They also suffer more harassment of different types. The risk profile of harassment indicates that older trans women are more likely to suffer harassment than younger ones, and the risk decreases each year they delay their gender identity disclosure. The elimination of transphobic attitudes and the promotion of gender justice should be priority strategies in Spain.

  6. Trans Fat Bans May Have Cut Heart Attack, Stroke Rate

    MedlinePlus

    ... 164605.html Trans Fat Bans May Have Cut Heart Attack, Stroke Rate Pending FDA regulations should remove nearly ... Could the contents of your cupcake affect your heart attack risk? It seems so, according to a new ...

  7. Supercritical fluid extraction of all-trans-lycopene from tomato.

    PubMed

    Gómez-Prieto, M Salud; Caja, M Mar; Herraiz, Marta; Santa-María, Guillermo

    2003-01-01

    A procedure is proposed for the supercritical fluid extraction of all-trans-lycopene from tomato using carbon dioxide at 40 degrees C without modifier. The present method minimizes the risk of degradation via isomerization and oxidation of health-promoting ingredients, such as lycopene. The effect of different experimental variables on the solvating power of the supercritical fluid was evaluated in terms of both the selectivity achievable in the process and the yield of the extraction of all-trans-lycopene. Satisfactory separations of the all-trans-lycopene isomers from the cis counterparts were achieved using a C(30) column. The obtained extract contained 88% all-trans-lycopene and 12% cis-lycopene.

  8. Synthesis, structural characterization, cytotoxicity in vitro, and effect on DNA of sulfate-trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV)

    NASA Astrophysics Data System (ADS)

    Jiménez-Pérez, Víctor M.; Muñoz-Flores, Blanca M.; Gómez, Alberto; Kharisov, Boris; Santillan, Rosa; Ochoa, María E.; Blanco Jerez, Leonor M.; García, Concepción; Waksman, Noemí; Ramírez, Rosalba

    2014-01-01

    The trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV) resulted from the reaction of dimethyl-tin(IV) dichloride and sodium sulfate in dimethylsulfoxide (DMSO). The tin compound was characterized by IR, NMR, FE-SEM, EDS, and single crystal X-ray diffraction studies. Suitable DMSO single crystals were obtained after 7 months by slow evaporation at room temperature. The crystal structure has a polymeric arrangement with eight-membered rings as a result of intermolecular coordination SO → Sn. The tin atom has an octahedral distorted geometry where the DMSO molecule is coordinated, and also has an infinite arrangement in 2D. Cytotoxicity against A431 cancer cells and MOLT4 leukemic cells and the DNA interaction of the organotin compound were determined. The organotin sulfate derivative showed low biological activity because of the polymeric structure and the saturated tin coordination capability.

  9. Biochemical diversity in the Trypanosoma congolense trans-sialidase family.

    PubMed

    Gbem, Thaddeus T; Waespy, Mario; Hesse, Bettina; Dietz, Frank; Smith, Joel; Chechet, Gloria D; Nok, Jonathan A; Kelm, Sørge

    2013-01-01

    Trans-sialidases are key enzymes in the life cycle of African trypanosomes in both, mammalian host and insect vector and have been associated with the disease trypanosomiasis, namely sleeping sickness and nagana. Besides the previously reported TconTS1, we have identified three additional active trans-sialidases, TconTS2, TconTS3 and TconTS4, and three trans-sialidase like genes in Trypanosoma congolense. At least TconTS1, TconTS2 and TconTS4 are found in the bloodstream of infected animals. We have characterised the enzymatic properties of recombinant proteins expressed in eukaryotic fibroblasts using fetuin as model blood glycoprotein donor substrate. One of the recombinant trans-sialidases, TconTS2, had the highest specific activity reported thus far with very low sialidase activity. The active trans-sialidases share all the amino acids critical for the catalytic reaction with few variations in the predicted binding site for the leaving or acceptor glycan. However, these differences cannot explain the orders of magnitudes between their transfer activities, which must be due to other unidentified structural features of the proteins or substrates selectivity. Interestingly, the phylogenetic relationships between the lectin domains correlate with their specific trans-sialylation activities. This raises the question whether and how the lectin domains regulate the trans-sialidase reaction. The identification and enzymatic characterisation of the trans-sialidase family in T. congolense will contribute significantly towards the understanding of the roles of these enzymes in the pathogenesis of Animal African Trypanosomiasis.

  10. Density and viscosity of tetralin and trans-decalin

    NASA Astrophysics Data System (ADS)

    Gonçalves, F. A.; Hamano, K.; Sengers, J. V.

    1989-07-01

    New measurements are reported for the density and viscosity of tetralin and trans-decalin. The density was determined from room temperature to 60°C for tetralin and to 95°C for trans-decalin. The kinematic viscosity was measured up to temperatures slightly above 100°C. Our results improve upon the values recommended by the American Petroleum Institute for these liquids.

  11. Trans-Himalayan Transport of Black Carbon

    NASA Astrophysics Data System (ADS)

    Panday, A. K.; Dhungel, S.; Mahata, K. S.

    2012-12-01

    Aerosol optical depth and black carbon concentrations over the Indo-Gangetic Plains and the Himalayan foothills have increased significantly in recent years, with potentially large consequences on monsoon circulation, air quality, and agriculture. At the same time, snowfields and glaciers on the Himalaya and the Tibetan Plateau have been shrinking in many areas, potentially driven by the arrival of increasing quantities of atmospheric black carbon from the Indo-Gangetic Plains. The high peaks of the Himalaya form a barrier that blocks the transport of moisture and pollutants from South Asia to the Tibetan Plateau. Thus it is likely that the handful of valleys that cut across the Himalaya would play a significant role in channeling the trans-Himalayan transport of black carbon. The Kali Gandaki Valley in Nepal is one such valley. It has long provided easy transit for migrating birds and traders traveling between South Asia and the Tibetan Plateau, and we have hypothesized that it is a major transit route for Tibetan Plateau bound black carbon. A network of weather stations set up by the University of Virginia and ICIMOD in 2009-2010 has found day-time up-valley winds with sustained speeds that often exceed 10-15 m/s throughout the year, occasionally reaching 25 m/s. Since Summer 2011 we have measured black carbon concentrations, aerosol optical depth, carbon monoxide and ozone at a station in Jomsom, Nepal, at the point north of the Annapurna Himalaya where the Kali Gandaki Valley opens up onto the Tibetan Plateau. Together with observations we have been carrying out south of the Annapurna, this provides the first set of observational data to allow an estimation of the transport of Black Carbon up through cross-Himalayan valleys. We provide initial calculations of the annual BC flux up the Kali Gandaki Valley, as well as first estimates of the flux through valleys across the entire Himalaya.

  12. Photo-induced chemical reaction of trans-resveratrol.

    PubMed

    Zhao, Yue; Shi, Meng; Ye, Jian-Hui; Zheng, Xin-Qiang; Lu, Jian-Liang; Liang, Yue-Rong

    2015-03-15

    Photo-induced chemical reaction of trans-resveratrol has been studied. UV B, liquid state and sufficient exposure time are essential conditions to the photochemical change of trans-resveratrol. Three principal compounds, cis-resveratrol, 2,4,6-phenanthrenetriol and 2-(4-hydroxyphenyl)-5,6-benzofurandione, were successively generated in the reaction solution of trans-resveratrol (0.25 mM, 100% ethanol) under 100 μW cm(-2) UV B radiation for 4h. cis-Resveratrol, originated from isomerization of trans-resveratrol, resulted in 2,4,6-phenanthrenetriol through photocyclisation reaction meanwhile loss of 2 H. 2,4,6-Phenanthrenetriol played a role of photosensitizer producing singlet oxygen in the reaction pathway. The singlet oxygen triggered [4+2] cycloaddition reaction of trans-resveratrol, and then resulted in the generation of 2-(4-hydroxyphenyl)-5,6-benzofurandione through photorearrangement and oxidation reaction. The singlet oxygen reaction was closely related to the substrate concentration of trans-resveratrol in solution.

  13. Stimulation of suicidal erythrocyte death by trans-cinnamaldehyde.

    PubMed

    Theurer, Michael; Shaik, Nazneen; Lang, Florian

    2013-09-15

    Trans-cinnamaldehyde, a component of leaves from Cinnamomum osmophloeum kaneh, has been shown to counteract tumor growth. The substance exerts its effect at least in part by triggering apoptosis. The propapoptotic signaling involves altered gene expression and mitochondrial depolarization. In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine-exposure at the cell surface. Triggers of eryptosis include increase of cytosolic Ca(2+)-activity ([Ca(2+)]i). The present study explored, whether trans-cinnamaldehyde triggers eryptosis. Cell volume has been estimated from forward scatter, phosphatidylserine-exposure from annexin-V-binding, hemolysis from hemoglobin release, and [Ca(2+)]i from Fluo3-fluorescence. A 48 h exposure to trans-cinnamaldehyde (30 μM) significantly decreased forward scatter and increased annexin-V-binding, effects paralleled by increase of [Ca(2+)]i. Trans-cinnamaldehyde exposure was followed by a slight but significant increase of hemolysis. Removal of extracellular Ca(2+) virtually abolished the effect of trans-cinnamaldehyde (30 μM) on annexin-V-binding. The present observations show that trans-cinnamaldehyde triggers suicidal death of erythrocytes, i.e. cells devoid of mitochondria and gene expression.

  14. SELF-POWERED WIRELESS SENSOR NODE POWER MODELING BASED ON IEEE 802.11 COMMUNICATION PROTOCOL

    SciTech Connect

    Vivek Agarwal; Raymond A. DeCarlo; Lefteri H. Tsoukalas

    2016-04-01

    considerations that must also be taken into account when computing the power consumption associated with each task. The considerations includes: number of events occurring in a fixed active time period and the duration of each event, event-information processing time, total communication time, number of retransmission, etc. Additionally, at the network level the communication of information data packets between WSNs involves collisions, latency, andretransmission, which result in unanticipated power losses. This paper presents stochastic modeling of power demand for a schedule-driven WSN utilizing Institute of Electrical and Electronics Engineers, IEEE, 802.11 communication protocols. The model captures the generic operation of a schedule-driven WSN when an external event occurs, i.e., sensing, following by processing, and followed by communication. The results are verified via simulation.

  15. 77 FR 22576 - Possible Revocation of Ocean Transportation Intermediary License No. 021899-Trans World Logistics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... Possible Revocation of Ocean Transportation Intermediary License No. 021899--Trans World Logistics Corporation; Order To Show Cause Trans World Logistics Corporation (Trans World Logistics) is an Indiana... Licensing (BCL) indicate that Trans World Logistics maintains its principal offices at 702 Penny...

  16. 76 FR 28026 - TransCanada Keystone Pipeline, LP; Notice of Request for Waiver

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... Energy Regulatory Commission TransCanada Keystone Pipeline, LP; Notice of Request for Waiver Take notice that on May 2, 2011, TransCanada Keystone Pipeline, LP (TransCanada Keystone) filed a request for... changes to its committed rates. TransCanada Keystone states that good cause exists to grant such a...

  17. A Thousand Words Are Worth a Picture: A Snapshot of Trans* Postsecondary Educators in Higher Education

    ERIC Educational Resources Information Center

    Simmons, Symone L.

    2017-01-01

    Trans* is becoming a buzzword and trans* celebrities have become increasingly visible. On college campuses, trans* students have also become more visible and advocacy for them continues to be extremely important. To support these claims, some literature has emerged regarding trans* college students' identity development and experiences on…

  18. Trans-interface diffusion-controlled coarsening

    NASA Astrophysics Data System (ADS)

    Ardell, Alan J.; Ozolins, Vidvuds

    2005-04-01

    Accurate theoretical predictions of the volume-fraction dependence during diffusion-controlled coarsening of a polydisperse assembly of particles have proved difficult. Here, a new model of coarsening is presented, involving diffusive transport through the coherent interface between ordered and disordered phases, which atomistic calculations show has a ragged structure. The interface is a diffusion bottleneck when the ordered phase is dispersed. It is predicted that the square of the average radius grows linearly with time, that the depletion of solute decreases as the inverse square-root of time, and that there is no effect of volume fraction on kinetics and the scaled particle-size distributions. These differ dramatically from predictions of modern theories of diffusion-controlled coarsening. Data on coarsening in Ni-Al alloys is examined. We show that no other theory is consistent with the experimentally observed absence of an effect of volume fraction on coarsening of ordered γ' (Ni3Al) precipitates in a disordered Ni-Al (γ) matrix, and the strong volume-fraction dependence of coarsening of γ precipitates in an ordered γ' matrix.

  19. Proportional Increase Multiplicative Decrease (PIMD) Wireless Scheduler: An Efficient Scheduler for IEEE 802.11e HCF

    NASA Astrophysics Data System (ADS)

    Hussain, Arshad; Qaiser, Shaban

    In this paper, we propose a new wireless scheduling algorithm for the IEEE 802.11e HCF. The algorithm grants the mobile stations variable time for the upstream data flow in proportion to the queue size of the transmission buffer. At the same time, it retrieves half of the extra time allocated in previous cycle from those flows whose requirement has stopped. Hence, the system achieves stability by preventing the ping-pong phenomena. The algorithm is computationally simple, and as compared to the other algorithms, it gives bounded delays and jitter to the real-time applications under heavy load conditions.

  20. Trans-Relativistic Particle Acceleration in Astrophysical Plasmas

    NASA Astrophysics Data System (ADS)

    Becker, Peter A.; Subramanian, P.

    2014-01-01

    Trans-relativistic particle acceleration due to Fermi interactions between charged particles and MHD waves helps to power the observed high-energy emission in AGN transients and solar flares. The trans-relativistic acceleration process is challenging to treat analytically due to the complicated momentum dependence of the momentum diffusion coefficient. For this reason, most existing analytical treatments of particle acceleration assume that the injected seed particles are already relativistic, and therefore they are not suited to study trans-relativistic acceleration. The lack of an analytical model has forced workers to rely on numerical simulations to obtain particle spectra describing the trans-relativistic case. In this work we present the first analytical solution to the global, trans-relativistic problem describing the acceleration of seed particles due to hard-sphere collisions with MHD waves. The new results include the exact solution for the steady-state Green's function resulting from the continual injection of monoenergetic seed particles with an arbitrary energy. We also introduce an approximate treatment of the trans-relativistic acceleration process based on a hybrid form for the momentum diffusion coefficient, given by the sum of the two asymptotic forms. We refer to this process as "quasi hard-sphere scattering." The main advantage of the hybrid approximation is that it allows the extension of the physical model to include (i) the effects of synchrotron and inverse-Compton losses and (ii) time dependence. The new analytical results can be used to model the trans-relativistic acceleration of particles in AGN and solar environments, and can also be used to compute the spectra of the associated synchrotron and inverse-Compton emission. Applications of both types are discussed. We highlight (i) relativistic ion acceleration in black hole accretion coronae, and (ii) the production of gyrosynchrotron microwave emission due to relativistic electron

  1. trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters.

    PubMed

    Simón, Edurne; Macarulla, M Teresa; Churruca, Itziar; Fernández-Quintela, Alfredo; Portillo, María P

    2006-02-01

    While conjugated linoleic acid (CLA) has received a great deal of attention as a supplement that can favourably modify body composition, its potential impact on insulin sensitivity has not received equal attention. The aim of the present work was to analyse the effects of trans-10,cis-12 CLA isomer on insulin sensitivity in hamsters fed an atherogenic diet. Hamsters were divided into three groups: one group was fed a chow diet (control) and the other two a semipurified atherogenic diet supplemented with 0.5% linoleic acid (LA) or trans-10,cis-12 CLA, respectively. Serum glucose, FFAs, insulin, leptin and adiponectin were measured using commercial kits. HOMA-IR was calculated using the formula of Matthews et al. PPARgamma mRNA was assessed in epididymal adipose tissue by reverse transcription-polymerase chain reaction (RT-PCR). After 6 weeks, atherogenic feeding produced an increase in body fat accumulation as compared with control feeding. The addition of trans-10,cis-12 CLA to the atherogenic diet avoided this feature. Atherogenic feeding also led to significantly higher serum concentrations of glucose, insulin, FFAs, as well as greater HOMA-IR values. trans-10,cis-12 CLA did not prevent these effects. No significant differences were found among experimental groups in serum leptin and adiponectin concentrations, nor in PPARgamma expression. In summary, although the addition of trans-10,cis-12 CLA to an atherogenic diet reduces fat accumulation, it does not improve the impairment of insulin action associated with this feeding. The maintenance of insulin resistance in hamsters fed the atherogenic CLA-enriched diet is probably due to the high serum FFA concentration observed in these animals.

  2. Effects of dietary trans-9 octadecenoic acid, trans-11 vaccenic acid and cis-9, trans-11 conjugated linoleic acid in mice.

    PubMed

    Wang, Tao; Lim, Ji-Na; Lee, Jae-Sung; Lee, Sang-Bum; Hwang, Jin-Hee; Jung, U-Suk; Kim, Min-Jeong; Hwang, Dae-Youn; Lee, Sang-Rak; Roh, Sang-Gun; Lee, Hong-Gu

    2015-08-01

    The aim of the present study was to investigate the effects of dietary trans fatty acids in mice. Following the administration of a 0.5/100 g diet of trans-9 octadecenoic acid (EA), trans-11 vaccenic acid (TVA) or cis-9, trans-11 conjugated linoleic acid (CLA) for 4 weeks, the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). The EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low-density lipoprotein and tumor necrosis factor-α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently. The potential effects of three well-known fatty acids, including trans-9 octadecenoic acid (EA), trans-11 vaccenic acid (TVA) and cis-9, trans-11 conjugated linoleic acid (CLA), in animals or humans remain to be elucidated. Therefore, in the present study, 32 animals were randomly divided into four groups and administered a 0.5/100 g diet of EA, TVA or CLA for 4 weeks. The results demonstrated that the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). Blood was collected individually via the external jugular veins and the EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low-density lipoprotein and tumor necrosis factor-α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently and these may further our understanding of the various effects of these fatty acids on animals and humans.

  3. Book of Abstracts, 1983 IEEE International Symposium on Applications of Ferroelectrics (ISAF).

    DTIC Science & Technology

    1984-05-31

    Preparation from Metal Alkoides (invited) - Y. Ozaki, Seikei University, Japan 5A-3 Aluminate- Sodalite Sr (al 12OA)(CrO )- A New Ferroelectric Matpria l...SrZrO, ZrTiO, NiFe 04 CoFe 04 CuFe 204V MgFe 2O04, (Ni,Zn)Fe 2 04, (Co,Zn)Fe 204 Aluminate- Sodalite Sr 8 (al 1 2 0 2 4 )(Cr0 4 2 - A New Ferroelectric...crystals of strontium-chromate aluminate- sodalite have been grown by the flux method. A first order ferroelectric phase transition occurs at287°K (upon

  4. [Determination of urinary trans, trans-muconic acid by high performance liquid chromatography].

    PubMed

    Liu, Liwen; Song, Shizhen; Hu, Xiamin; Ye, Fangli

    2006-05-01

    A method for the determination of urinary trans, trans-muconic acid (tt-MA) (benzene metabolite) by high performance liquid chromatography (HPLC) was developed. The separation was carried out on a C18 column (Spherisorb C18, 150 mm x 4.6 mm i. d. , 5 microm) at 25 degrees C with glacial acetic acid-tetrahydrofuran-methanol-water (1 : 2 : 10: 87, v/v) as mobile phase. Urinary sample was acidified by 2 mol/L hydrochloric acid and pretreated by liquid-liquid extraction using diethyl ether. After removal of diethyl ether with a stream of nitrogen, the residue was re-dissolved in 1 mL of mobile phase for HPLC injection. Good linearity was observed within the range from 0.10 mg/L to 10.00 mg/L (r =0.9999) and the detection limit was 0.10 mg/L. The average recoveries for tt-MA were 95.1%-100.5%. Relative standard deviations (RSD) for intra-day and inter-day determinations were 4.0%-9.0% and 6.2%-8.8%, respectively. The method was applied to 56 benzene-exposed workers and 24 controll workers. Urinary tt-MA in benzen-exposed workers were significantly higher than that in the control group. They can be correlated with benzene exposure concentrations (P <0.01). This analytical method for tt-MA is sensitive, rapid, and convenient. It is suitable for monitoring of occupational exposure to benzene and toxic kinetics studies.

  5. 21 CFR 573.637 - Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Methyl esters of conjugated linoleic acid (cis-9... § 573.637 Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic acids). The food additive, methyl esters of conjugated linoleic acid (cis-9, trans-11 and...

  6. Metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4

    SciTech Connect

    Short, Duncan M.; Lyon, Robert; Watson, David G.; Barski, Oleg A.; McGarvie, Gail; Ellis, Elizabeth M. . E-mail: Elizabeth.ellis@strath.ac.uk

    2006-01-15

    The reductive metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, was studied in mouse liver. Using an HPLC-based stopped assay, the primary reduced metabolite was identified as 6-hydroxy-trans, trans-2,4-hexadienal (OH/CHO) and the secondary metabolite as 1,6-dihydroxy-trans, trans-2,4-hexadiene (OH/OH). The main enzymes responsible for the highest levels of reductase activity towards trans, trans-muconaldehyde were purified from mouse liver soluble fraction first by Q-sepharose chromatography followed by either blue or red dye affinity chromatography. In mouse liver, trans, trans-muconaldehyde is predominantly reduced by an NADH-dependent enzyme, which was identified as alcohol dehydrogenase (Adh1). Kinetic constants obtained for trans, trans-muconaldehyde with the native Adh1 enzyme showed a V {sub max} of 2141 {+-} 500 nmol/min/mg and a K {sub m} of 11 {+-} 4 {mu}M. This enzyme was inhibited by pyrazole with a K {sub I} of 3.1 {+-} 0.57 {mu}M. Other fractions were found to contain muconaldehyde reductase activity independent of Adh1, and one enzyme was identified as the NADPH-dependent aldehyde reductase AKR1A4. This showed a V {sub max} of 115 nmol/min/mg and a K {sub m} of 15 {+-} 2 {mu}M and was not inhibited by pyrazole.

  7. An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system.

    PubMed

    Yoshida, Hiroshi; Bando, Tetsuya; Mito, Taro; Ohuchi, Hideyo; Noji, Sumihare

    2014-03-11

    What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination.

  8. An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system

    PubMed Central

    Yoshida, Hiroshi; Bando, Tetsuya; Mito, Taro; Ohuchi, Hideyo; Noji, Sumihare

    2014-01-01

    What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination. PMID:24613915

  9. Optical applications of von Neumann's alternating-projection theorem.

    PubMed

    Montgomery, W D

    1982-01-01

    The previous work of Gerchberg [Opt. Acta 21, 709 (1974)], Papoulis [IEEE Trans. Circuits Syst. CAS-22, 735 (1975)], Youla [IEEE Trans. Circuits Syst. CAS-25, 694 (1978)], and Stark et al. [J. Opt. Soc. Am. 71, 735 (1981)] on image restoration is presented in a generalized setting. New examples using three projections are given. The method is used to solve the general problem of diffraction by a perfectly conducting plane screen of arbitrary configuration.

  10. Signal Analysis Techniques for Interpreting Electroencephalograms

    DTIC Science & Technology

    1980-12-01

    et al. Near-orthogonal basis functions: A real time fetal ECG technique. IEEE Trans Biomed Eng BME-24:39-43 (1971. 66. MacKay, D. M., and D. A...multivariate and nonlinear time series analysis of fetal heart rate. Ph.D. Dissertation, Carnegie-wellon Univ., Pittsburgh, Pa., 1979. Jarisch, W...of fetal heart rate variability. IEEE Trans Biomed Eng (Submitted, 1979). Johnson, A. S. Automated detection of petit mal seizures in the human EEG

  11. Trans-inactivation: Repression in a wrong place.

    PubMed

    Shatskikh, Aleksei S; Abramov, Yuriy A; Lavrov, Sergey A

    2016-08-19

    Trans-inactivation is the repression of genes on a normal chromosome under the influence of a rearranged homologous chromosome demonstrating the position effect variegation (PEV). This phenomenon was studied in detail on the example of brown(Dominant) allele causing the repression of wild-type brown gene on the opposite chromosome. We have investigated another trans-inactivation-inducing chromosome rearrangement, In(2)A4 inversion. In both cases, brown(Dominant) and In(2)A4, the repression seems to be the result of dragging of the euchromatic region of the normal chromosome into the heterochromatic environment. It was found that cis-inactivation (classical PEV) and trans-inactivation show different patterns of distribution along the chromosome and respond differently to PEV modifying genes. It appears that the causative mechanism of trans-inactivation is de novo heterochromatin assembly on euchromatic sequences dragged into the heterochromatic nuclear compartment. Trans-inactivation turns out to be the result of a combination of heterochromatin-induced position effect and the somatic interphase chromosome pairing that is widespread in Diptera.

  12. [Sexuality and trans experiences: from the hospital to the bedroom].

    PubMed

    Bento, Berenice

    2012-10-01

    In the aftermath of studies on masculinity, it is impossible to consider the production of gender identities without linking them to the relationship aspect. This change was due to the incorporation of the relationship perspective in this field of study and criticism of the concept of gender founded upon an alleged concept of femininity and masculinity to create interpretations of the place of bodies in the gender order. The objectives of this paper are: 1) to show how a given concept of gender can render multiple expressions of gender visible, like the trans identities (transsexuals, transvestites, cross dressers, drag queens, drag kings, transgenders) or sublimate them and contribute to their pathologization. The second objective will be to present narratives of trans men and trans women, who will tell us about their sexual experiences. Psycho-physicians contend the non-existence of sexuality in their bodies as being one of the indicators to lead to a diagnosis of transsexualism. I will attempt to argue that the theoretical basis that supports the pathologization of trans identities and the assertion that trans people are asexual is based on a conception that links and renders gender identities conditional upon biological structures.

  13. AL Amyloidosis

    PubMed Central

    2012-01-01

    Definition of the disease AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig) light chains (LC) (most commonly of lambda isotype) usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multiple myeloma or other B-cell lymphoproliferative disorders is unusual. The key event in the development of AL amyloidosis is the change in the secondary or tertiary structure of an abnormal monoclonal LC, which results in instable conformation. This conformational change is responsible for abnormal folding of the LC, rich in β leaves, which assemble into monomers that stack together to form amyloid fibrils. Epidemiology AL amyloidosis is the most common type of systemic amyloidois in developed countries with an estimated incidence of 9 cases/million inhabitant/year. The average age of diagnosed patients is 65 years and less than 10% of patients are under 50. Clinical description The clinical presentation is protean, because of the wide number of tissues or organs that may be affected. The most common presenting symptoms are asthenia and dyspnoea, which are poorly specific and may account for delayed diagnosis. Renal manifestations are the most frequent, affecting two thirds of patients at presentation. They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients. Heart involvement, which is present at diagnosis in more than 50% of patients, leading to restrictive cardiopathy, is the most serious complication and engages prognosis. Diagnostic methods The diagnosis relies on pathological examination of an involved site showing Congo red-positive amyloid deposits, with typical apple-green birefringence under polarized light, that stain positive with an anti-LC antibody by immunohistochemistry and/or immunofluorescence. Due to the

  14. Status of the IEEE P1547 Draft Interconnection Standard and Distributed Energy Resources R&D: Preprint

    SciTech Connect

    Thomas, H. P.; Basso, T. S.; Kroposki, B.

    2002-05-01

    The Department of Energy (DOE) Distributed Power Program (DPP) is conducting work to complete, validate in the field, and support the development of a national interconnection standard for distributed energy resources (DER), and to address the institutional and regulatory barriers slowing the commercial adoption of DER systems. This work includes support for the IEEE standards, including P1547 Standard for Interconnecting Distributed Resources with Electric Power Systems, P1589 Standard for Conformance Test Procedures for Equipment Interconnecting Distributed Resources with Electric Power Systems, and the P1608 Application Guide. Work is also in progress on system integration research and development (R&D) on the interface and control of DER with local energy systems. Additional efforts are supporting high-reliability power for industry, evaluating innovative concepts for DER applications, and exploring plug-and-play interface and control technologies for intelligent autonomous interconnection systems. This paper summarizes (1) the current status of the IEEE interconnection standards and application guides in support of DER, and (2) the R&D in progress at the National Renewable Energy Laboratory (NREL) for interconnection and system integration and application of distributed energy resources.

  15. Evaluation of IEEE 802.11g and 802.16 for Lunar Surface Exploration Missions Using MACHETE Simulations

    NASA Technical Reports Server (NTRS)

    Segui, John; Jennings, Esther; Vyas, Hemali

    2009-01-01

    In this paper, we investigated the suitability of terrestrial wireless networking technologies for lunar surface exploration missions. Specifically, the scenario we considered consisted of two teams of collaborating astronauts, one base station and one rover, where the base station and the rover have the capability of acting as relays. We focused on the evaluation of IEEE 802.11g and IEEE 802.16 protocols, simulating homogeneous 802.11g network, homogeneous 802.16 network, and heterogeneous network using both 802.11g and 802.16. A mix of traffic flows were simulated, including telemetry, caution and warning, voice, command and file transfer. Each traffic type had its own distribution profile, data volume, and priority. We analyzed the loss and delay trade-offs of these wireless protocols with various link-layer options. We observed that 802.16 network managed the channel better than an 802.11g network due to controlled infrastructure and centralized scheduling. However, due to the centralized scheduling, 802.16 also had a longer delay. The heterogeneous (hybrid) of 802.11/802.16 achieved a better balance of performance in terms of data loss and delay compared to using 802.11 or 802.16 alone.

  16. Path loss variation of on-body UWB channel in the frequency bands of IEEE 802.15.6 standard.

    PubMed

    Goswami, Dayananda; Sarma, Kanak C; Mahanta, Anil

    2016-06-01

    The wireless body area network (WBAN) has gaining tremendous attention among researchers and academicians for its envisioned applications in healthcare service. Ultra wideband (UWB) radio technology is considered as excellent air interface for communication among body area network devices. Characterisation and modelling of channel parameters are utmost prerequisite for the development of reliable communication system. The path loss of on-body UWB channel for each frequency band defined in IEEE 802.15.6 standard is experimentally determined. The parameters of path loss model are statistically determined by analysing measurement data. Both the line-of-sight and non-line-of-sight channel conditions are considered in the measurement. Variations of parameter values with the size of human body are analysed along with the variation of parameter values with the surrounding environments. It is observed that the parameters of the path loss model vary with the frequency band as well as with the body size and surrounding environment. The derived parameter values are specific to the particular frequency bands of IEEE 802.15.6 standard, which will be useful for the development of efficient UWB WBAN system.

  17. Performance analyses and improvements for the IEEE 802.15.4 CSMA/CA scheme with heterogeneous buffered conditions.

    PubMed

    Zhu, Jianping; Tao, Zhengsu; Lv, Chunfeng

    2012-01-01

    Studies of the IEEE 802.15.4 Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA) scheme have been received considerable attention recently, with most of these studies focusing on homogeneous or saturated traffic. Two novel transmission schemes-OSTS/BSTS (One Service a Time Scheme/Bulk Service a Time Scheme)-are proposed in this paper to improve the behaviors of time-critical buffered networks with heterogeneous unsaturated traffic. First, we propose a model which contains two modified semi-Markov chains and a macro-Markov chain combined with the theory of M/G/1/K queues to evaluate the characteristics of these two improved CSMA/CA schemes, in which traffic arrivals and accessing packets are bestowed with non-preemptive priority over each other, instead of prioritization. Then, throughput, packet delay and energy consumption of unsaturated, unacknowledged IEEE 802.15.4 beacon-enabled networks are predicted based on the overall point of view which takes the dependent interactions of different types of nodes into account. Moreover, performance comparisons of these two schemes with other non-priority schemes are also proposed. Analysis and simulation results show that delay and fairness of our schemes are superior to those of other schemes, while throughput and energy efficiency are superior to others in more heterogeneous situations. Comprehensive simulations demonstrate that the analysis results of these models match well with the simulation results.

  18. Standard-compliant real-time transmission of ECGs: harmonization of ISO/IEEE 11073-PHD and SCP-ECG.

    PubMed

    Trigo, Jesús D; Chiarugi, Franco; Alesanco, Alvaro; Martínez-Espronceda, Miguel; Chronaki, Catherine E; Escayola, Javier; Martínez, Ignacio; García, José

    2009-01-01

    Ambient assisted living and integrated care in an aging society is based on the vision of the lifelong Electronic Health Record calling for HealthCare Information Systems and medical device interoperability. For medical devices this aim can be achieved by the consistent implementation of harmonized international interoperability standards. The ISO/IEEE 11073 (x73) family of standards is a reference standard for medical device interoperability. In its Personal Health Device (PHD) version several devices have been included, but an ECG device specialization is not yet available. On the other hand, the SCP-ECG standard for short-term diagnostic ECGs (EN1064) has been recently approved as an international standard ISO/IEEE 11073-91064:2009. In this paper, the relationships between a proposed x73-PHD model for an ECG device and the fields of the SCP-ECG standard are investigated. A proof-of-concept implementation of the proposed x73-PHD ECG model is also presented, identifying open issues to be addressed by standards development for the wider interoperability adoption of x73-PHD standards.

  19. Validation testing of ANSI/IEEE n42.49 standard requirements for personal emergency radiation detectors.

    PubMed

    Pibida, L; Minniti, R; O'Brien, M

    2010-04-01

    Various radiation detectors including electronic personal emergency radiation detectors (PERDs), radiochromic film cards and thermoluminescent dosimeters (TLDs) were used to validate a subset of the radiological test requirements listed in the American National Standards Institute/The Institute of Electrical and Electronic Engineers (ANSI/IEEE) N42.49 standard. The subset of tests included the following: comparing the readout of the detectors with the value given at the National Institute of Standards and Technology (NIST); testing of the alarm settings (when applicable) in air-kerma (or exposure) and air-kerma rate (or exposure rate) mode; and investigating the effect of testing the detectors mounted on a phantom and free in air. The purpose of this work was not to test the performance of the sample of detectors used. Instead, the detectors were used to validate the requirements of the written standard being developed. For this purpose, the performance and response of these instruments were recorded when placed in (137)Cs, and x-ray beams at different air-kerma rates and test conditions. The measurements described in this report were performed at the NIST x-ray and gamma-ray radiation calibration facilities. The data in this report provide a benchmark in support of the development of the ANSI/IEEE N42.49 standard.

  20. Improving the communication reliability of body sensor networks based on the IEEE 802.15.4 protocol.

    PubMed

    Gomes, Diogo; Afonso, José A

    2014-03-01

    Body sensor networks (BSNs) enable continuous monitoring of patients anywhere, with minimum constraints to daily life activities. Although the IEEE 802.15.4 and ZigBee(®) (ZigBee Alliance, San Ramon, CA) standards were mainly developed for use in wireless sensors network (WSN) applications, they are also widely used in BSN applications because of device characteristics such as low power, low cost, and small form factor. However, compared with WSNs, BSNs present some very distinctive characteristics in terms of traffic and mobility patterns, heterogeneity of the nodes, and quality of service requirements. This article evaluates the suitability of the carrier sense multiple access-collision avoidance protocol, used by the IEEE 802.15.4 and ZigBee standards, for data-intensive BSN applications, through the execution of experimental tests in different evaluation scenarios, in order to take into account the effects of contention, clock drift, and hidden nodes on the communication reliability. Results show that the delivery ratio may decrease substantially during transitory periods, which can last for several minutes, to a minimum of 90% with retransmissions and 13% without retransmissions. This article also proposes and evaluates the performance of the BSN contention avoidance mechanism, which was designed to solve the identified reliability problems. This mechanism was able to restore the delivery ratio to 100% even in the scenario without retransmissions.

  1. Performance evaluation of complete data transfer of physical layer according to IEEE 802.15.4 standard

    NASA Astrophysics Data System (ADS)

    Raju, Kota Solomon; Merugu, Naresh Babu; Neetu, Babu, E. Ram

    2016-03-01

    ZigBee is well-accepted industrial standard for wireless sensor networks based on IEEE 802.15.4 standard. Wireless Sensor Networks is the major concern of communication these days. These Wireless Sensor Networks investigate the properties of networks of small battery-powered sensors with wireless communication. The communication between any two wireless nodes of wireless sensor networks is carried out through a protocol stack. This protocol stack has been designed by different vendors in various ways. Every custom vendor possesses his own protocol stack and algorithms especially at the MAC layer. But, many applications require modifications in their algorithms at various layers as per their requirements, especially energy efficient protocols at MAC layer that are simulated in Wireless sensor Network Simulators which are not being tested in real time systems because vendors do not allow the programmability of each layer in their protocol stack. This problem can be quoted as Vendor-Interoperability. The solution is to develop the programmable protocol stack where we can design our own application as required. As a part of the task first we tried implementing physical layer and transmission of data using physical layer. This paper describes about the transmission of the total number of bytes of Frame according to the IEEE 802.15.4 standard using Physical Layer.

  2. Compliance and Functional Testing of IEEE 1451.1 for NCAP-to-NCAP Communications in a Sensor Network

    NASA Technical Reports Server (NTRS)

    Figueroa, Jorge; Gurkan, Deniz; Yuan, X.; Benhaddou, D.; Liu, H.; Singla, A.; Franzl, R.; Ma, H.; Bhatt, S.; Morris, J.; Turowski, M.; Figueroa, F.

    2008-01-01

    Distributed control in a networked environment is an irreplaceable feature in systems with remote sensors and actuators. Although distributed control was not originally designed to be networked, usage of off-the-shelf networking technologies has become so prevalent that control systems are desired to have access mechanisms similar to computer networks. However, proprietary transducer interfaces for network communications and distributed control overwhelmingly dominate this industry. Unless the lack of compatibility and interoperability among transducers is resolved, the mature level of access (that computer networking can deliver) will not be achieved in such networked distributed control systems. Standardization of networked transducer interfaces will enable devices from different manufacturers to talk to each other and ensure their plug-and-play capability. One such standard is the suite of IEEE 1451 for sensor network communication and transducer interfaces. The suite not only provides a standard interface for smart transducers, but also outlines the connection of an NCAP (network capable application processor) and transducers (through a transducer interface module TIM). This paper presents the design of the compliance testing of IEEE 1451.1 (referred to as Dot1) compatible NCAP-to-NCAP communications on a link-layer independent medium. The paper also represents the first demonstration of NCAP-to-NCAP communications with Dot1 compatibility: a tester NCAP and an NCAP under test (NUT).

  3. The Sensitivity to Trans-Neptunian Dwarf Planets of the Siding Spring Survey

    NASA Astrophysics Data System (ADS)

    Bannister, Michele; Brown, M. E.; Schmidt, B. P.; Francis, P.; McNaught, R.; Garrad, G.; Larson, S.; Beshore, E.

    2012-10-01

    The last decade has seen considerable effort in assessing the populations of icy worlds in the outer Solar System, with major surveys in the Northern and more recently, in the Southern Hemisphere skies. Our archival search of more than ten thousand square degrees of sky south of the ecliptic observed over five years is a bright-object survey, sensitive to dwarf-planet sized trans-Neptunian objects. Our innovative survey analyses observations of the Siding Spring Survey, an ongoing survey for near-Earth asteroids at the 0.5 m Uppsala telescope at Siding Spring Observatory. This survey observed each of 2300 4.55 square degree fields on between 30 and 90 of the nights from early 2004 to late 2009, creating a dataset with dense temporal coverage, which we reprocessed for TNOs with a dedicated pipeline. We assess our survey's sensitivity to trans-Neptunian objects by simulating the observation of the synthetic outer Solar System populations of Grav et al. (2011): Centaurs, Kuiper belt and scattered disk. As our fields span approx. -15 to -70 declination, avoiding the galactic plane by 10 degrees either side, we are particularly sensitive to dwarf planets in high-inclination orbits. Partly due to this coverage far from the ecliptic, all known dwarf planets, including Pluto, do fall outside our survey coverage in its temporal span. We apply the widest plausible range of absolute magnitudes to each observable synthetic object, measuring each subsequent apparent magnitude against the magnitude depth of the survey observations. We evaluate our survey's null detection of new dwarf planets in light of our detection efficiencies as a function of trans-Neptunian orbital parameter space. MTB appreciates the funding support of the Joan Duffield Postgraduate Scholarship, an Australian Postgraduate Award, and the Astronomical Society of Australia.

  4. CryoTran user's manual, version 1.0

    NASA Technical Reports Server (NTRS)

    Cowgill, Glenn R.; Chato, David J.; Saad, Ehab

    1989-01-01

    The development of cryogenic fluid management systems for space operation is a major portion of the efforts of the Cryogenic Fluids Technology Office (CFTO) at the NASA Lewis Research Center. Analytical models are a necessary part of experimental programs which are used to verify the results of experiments and are also used as a predictor for parametric studies. The CryoTran computer program is a bridge to obtain analytical results. The object of CryoTran is to coordinate these separate analyses into an integrated framework with a user-friendly interface and a common cryogenic property database. CryoTran is an integrated software system designed to help solve a diverse set of problems involving cryogenic fluid storage and transfer in both ground and low-g environments.

  5. In trans promoter activation by enhancers in transient transfection.

    PubMed

    Smirnov, N A; Akopov, S B; Didych, D A; Nikolaev, L G

    2017-03-01

    Earlier, it was reported that the strong cytomegalovirus enhancer can activate the cytomegalovirus promoter in trans, i.e. as a separate plasmid co-transfected with a promoter-reporter gene construct. Here we demonstrate that the ability of enhancers to activate promoters in trans in transient transfection experiments is a property of not only viral regulatory elements but also of various genomic enhancers and promoters. Enhancer-promoter activation in trans is promoter- and cell type-specific, and accompanied by physical interaction between promoter and enhancer as revealed by chromosome conformation capture assays. Thus, promoter activation in transient co-transfection of promoters and enhancers shares a number of important traits with long-distance promoter activation by enhancers in living cells and may therefore serve as a model of this fundamental cellular process.

  6. Trans fat intake in children: risks and recommendations.

    PubMed

    Bauer, Lindsay R; Waldrop, Julee

    2009-01-01

    Partially hydrogenated oils, also known as trans fat, are found in many baked goods, snack foods, fast foods, margarines, and shortening. Partially hydrogenated oil is vegetable oil that has been modified to be solid at room temperature and lengthens the shelf life of products in which it is used. Consumption of trans fat has been linked to negative changes in lipoproteins, systemic inflammation, coronary heart disease, and diabetes mellitus. Evidence of processes leading to these conditions has also been found in children. Dietary habits and preferences are established in early childhood; therefore, it is important to intervene early with parents to help them make healthier food choices for their families. Educational intervention should reflect successful programs, be based on a theoretical model, and focus on the adverse health effects of consuming trans fat and the importance of choosing a diet that favors unprocessed foods.

  7. Dendritic Cells and HIV-1 Trans-Infection

    PubMed Central

    McDonald, David

    2010-01-01

    Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious synapse. This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro and is thought to contribute to viral dissemination in vivo. This review outlines the recent data defining the mechanisms of trans-infection and provides a context for the potential contribution of trans-infection in HIV-1 disease. PMID:21994702

  8. Human exposure standards in the frequency range 1 Hz To 100 kHz: the case for adoption of the IEEE standard.

    PubMed

    Patrick Reilly, J

    2014-10-01

    Differences between IEEE C95 Standards (C95.6-2002 and C95.1-2005) in the low-frequency (1 Hz-100 kHz) and the ICNIRP-2010 guidelines appear across the frequency spectrum. Factors accounting for lack of convergence include: differences between the IEEE standards and the ICNIRP guidelines with respect to biological induction models, stated objectives, data trail from experimentally derived thresholds through physical and biological principles, selection and justification of safety/reduction factors, use of probability models, compliance standards for the limbs as distinct from the whole body, defined population categories, strategies for central nervous system protection below 20 Hz, and correspondence of environmental electric field limits with contact currents. This paper discusses these factors and makes the case for adoption of the limits in the IEEE standards.

  9. The definition of basic TEDS of IEEE 1451.4 for sensors for an electronic tongue and the proposal of new template TEDS for electrochemical devices.

    PubMed

    Kim, Jeong-Do; Kim, Dong-Jin; Byun, Hyung-Gi; Ham, Yu-Kyung; Jung, Woo-Suk; Han, Dong-Won; Park, Jun-Seok; Lee, Hyo-Lin

    2007-03-15

    It is important to define a standard method to store basic sensor information, such as the type and the structure of sensors for an electronic tongue system and there is no such method defined in the IEEE 1451.4 transducer electronic data sheet (TEDS) so far. The major challenge is to choose a suitable standard template that can be used with sensors for electronic tongues. However, the standard templates provide an imprecise specification when used with sensing devices for electronic tongues. In this paper, we present definitions of the basic TEDS of IEEE 1451.4 for sensors for an electronic tongue system and propose a new template TEDS for IEEE 1451.4 for potentiometric devices.

  10. Lattice dynamics and conjugation length in Trans-polyacetylene

    NASA Astrophysics Data System (ADS)

    Piseri, L.; Tubino, R.; Paltrinieri, L.; Dellepiane, G.

    1983-04-01

    A force field for the infinite trans-polyene chain which includes the contribution of delocalized forces is proposed. Phonon energies throughout the Brillouin zone are evaluated and compared with the i.r. and Raman data of trans-polyacetylene and with the C=C streching frequencies of a number of short polyenes. The experimental resonant Raman bandshapes for (CH) χ and (CD) χ are well accounted for by the calculated dispersion of the phonon frequencies. Some conclusions on the conjugation length of the polymer are reached.

  11. trans-Bis(benzyl-diphenyl-phosphane-κP)dichloridoplatinum(II).

    PubMed

    Muller, Alfred

    2012-12-01

    In the mononuclear title compound, trans-[PtCl2(C19H17P)2], the slightly distorted square-planar coordination sphere of the Pt(II) atom is occupied by two benzyl-diphenyl-phosphane ligands and two chloride atoms in a mutually trans geometry. The effective cone angles for the two phosphane ligands are 160 and 169°. C-H⋯Cl inter-actions generate infinite long chains along [01-1]. Additional C-H⋯π and π-π stacking interactions [centroid-centroid distance = 4.2499 (15) Å and ring slippage = 2.386 Å] are observed.

  12. After runaway: The trans-Hill stage of planetesimal growth

    SciTech Connect

    Lithwick, Yoram

    2014-01-01

    When planetesimals begin to grow by coagulation, they first enter an epoch of runaway, during which the biggest bodies grow faster than all the others. The questions of how runaway ends and what comes next have not been answered satisfactorily. We show that runaway is followed by a new stage—the 'trans-Hill stage'—that commences when the bodies that dominate viscous stirring ('big bodies') become trans-Hill, i.e., when their Hill velocity matches the random speed of the small bodies they accrete. Subsequently, the small bodies' random speed grows in lockstep with the big bodies' sizes, such that the system remains in the trans-Hill state. Trans-Hill growth is crucial for determining the efficiency of growing big bodies, as well as their growth timescale and size spectrum. Trans-Hill growth has two sub-stages. In the earlier one, which occurs while the stirring bodies remain sufficiently small, the evolution is collisionless, i.e., collisional cooling among all bodies is irrelevant. The efficiency of forming big bodies in this collisionless sub-stage is very low, ∼10α << 1, where α ∼ 0.005(a/AU){sup –1} is the ratio between the physical size of a body and its Hill radius. Furthermore, the size spectrum is flat (equal mass per size decade, i.e., q = 4). This collisionless trans-Hill solution explains results from previous coagulation simulations for both the Kuiper Belt and the asteroid belt. The second trans-Hill sub-stage commences once the stirring bodies grow big enough (>α{sup –1} × the size of the accreted small bodies). After that time, collisional cooling among small bodies controls the evolution. The efficiency of forming big bodies rises and the size spectrum becomes more top heavy. Trans-Hill growth can terminate in one of two ways, depending on the sizes of the small bodies. First, mutual accretion of big bodies can become significant and conglomeration proceeds until half of the total mass is converted into big bodies. This mode of growth

  13. Trans women and Michfest: An ethnophenomenology of attendees' experiences.

    PubMed

    McConnell, Elizabeth A; Odahl-Ruan, Charlynn A; Kozlowski, Christine; Shattell, Mona; Todd, Nathan R

    2016-01-01

    The rise of queer and transgender studies has greatly contributed to feminist and lesbian understandings of sex, gender, and sexuality and also has resulted in rifts, tensions, and border wars. One such tension is around the inclusion of trans women in women-only space, such as the Michigan Womyn's Music Festival (Michfest). In this ethnophenomenological study, we interviewed and surveyed 43 cisgender women who attended Michfest in 2013. Participants had a variety of perspectives on trans inclusion and on the dialogue surrounding it, and these paralleled intersections, frictions, and tensions between feminism, queer theory, and transgender studies.

  14. Observational Constraints on Planet Nine: Astrometry of Pluto and Other Trans-Neptunian Objects

    NASA Astrophysics Data System (ADS)

    Holman, Matthew J.; Payne, Matthew J.

    2016-10-01

    We use astrometry of Pluto and other trans-neptunian objects to constrain the sky location, distance, and mass of the possible additional planet (Planet Nine) hypothesized by Batygin & Brown. We find that over broad regions of the sky, the inclusion of a massive, distant planet degrades the fits to the observations. However, in other regions, the fits are significantly improved by the addition of such a planet. Our best fits suggest a planet that is either more massive or closer than argued for by Batygin & Brown based on the orbital distribution of distant trans-neptunian objects (or by Fienga et al. based on range measured to the Cassini spacecraft). The trend to favor larger and closer perturbing planets is driven by the residuals to the astrometry of Pluto, remeasured from photographic plates using modern stellar catalogs, which show a clear trend in decl. over the course of two decades, that drive a preference for large perturbations. Although this trend may be the result of systematic errors of unknown origin in the observations, a possible resolution is that the decl. trend may be due to perturbations from a body, in addition to Planet Nine, that is closer to Pluto but less massive than Planet Nine.

  15. Haumea, an intriguing Water Ice Surface in the transNeptunian Belt

    NASA Astrophysics Data System (ADS)

    Pinilla-Alonso, N.

    2010-12-01

    Discovered in 2005 by Santos-Sanz in 2005, (136108) Haumea is one of the four Dwarf Planets in the trans-Neptunian belt and the only one that shows water ice on its surface (Pinilla-Alonso et al. 2006, Brown et al. 2006). Its spectrum in the visible and near-infrared is dominated by absorptions of water ice and does not show any feature due to other constituents previously suggested (Trujillo et al. 2007). These (e.g HCN, CH4, pyroxenes, hydrated ammonia) are completely discarded by modeling of the reflectance (Pinilla-Alonso et al. 2009) in the visible and near-infrared range. Other characteristic of it spectrum is the absence of color in the visible wavelengths (S'(vis) = 0.0±2 [%/1000 Å]) which is indicative of the lack of complex organics. Rotationally resolved models of its reflectance at 5 different phases covering an 80% of the surface (Pinilla-Alonso et al. 2009) reveal a fairly homogeneous surface covered with water ice up to a 92%, with a upper limit of 8% for all the other studied materials. This composition is in agreement with the high albedo estimated for this object ( ~70%, Rabinowitz et al. 2007) Surprisingly, this characteristic is shared by a small group of TNOs, Haumea's cohort, that shows very similar orbital parameters (Brown et al. 2007, Pinilla-Alonso et al. 2007) A signature around 1.65 microns, in the spectrum of Haumea, indicates the presence of crystalline water ice. This was first interpreted by Rabinowitz et al. (2008) as a proof of the youth of its surface. But later, it was showed that this band is compatible with the presence of a 50% of amorphous ice indicative of a moderately old surface (> 100 Myr) (Pinilla-Alonso et al. 2009) I will present here simulations of how the irradiation and collisional resurfacing affect the surface of this TNO. As Gil-Hutton (2009) explains, a collisional event releases energy that could be partially converted into heat that would produce the crystallization of water ice, but the eroded material

  16. An Improved Cross-Layering Design for IPv6 Fast Handover with IEEE 802.16m Entry Before Break Handover

    NASA Astrophysics Data System (ADS)

    Kim, Ronny Yongho; Jung, Inuk; Kim, Young Yong

    IEEE 802.16m is an advanced air interface standard which is under development for IMT-Advanced systems, known as 4G systems. IEEE 802.16m is designed to provide a high data rate and a Quality of Service (QoS) level in order to meet user service requirements, and is especially suitable for mobilized environments. There are several factors that have great impact on such requirements. As one of the major factors, we mainly focus on latency issues. In IEEE 802.16m, an enhanced layer 2 handover scheme, described as Entry Before Break (EBB) was proposed and adopted to reduce handover latency. EBB provides significant handover interruption time reduction with respect to the legacy IEEE 802.16 handover scheme. Fast handovers for mobile IPv6 (FMIPv6) was standardized by Internet Engineering Task Force (IETF) in order to provide reduced handover interruption time from IP layer perspective. Since FMIPv6 utilizes link layer triggers to reduce handover latency, it is very critical to jointly design FMIPv6 with its underlying link layer protocol. However, FMIPv6 based on new handover scheme, EBB has not been proposed. In this paper, we propose an improved cross-layering design for FMIPv6 based on the IEEE 802.16m EBB handover. In comparison with the conventional FMIPv6 based on the legacy IEEE 802.16 network, the overall handover interruption time can be significantly reduced by employing the proposed design. Benefits of this improvement on latency reduction for mobile user applications are thoroughly investigated with both numerical analysis and simulation on various IP applications.

  17. Use of Trans Fat Information on Food Labels and Its Determinants in a Multiethnic College Student Population

    ERIC Educational Resources Information Center

    Jasti, Sunitha; Kovacs, Szilvia

    2010-01-01

    Objectives: To examine the correlates of trans fat knowledge and trans fat label use; to examine the influence of trans fat knowledge, trans fat label use, and dietary attitudes on intake of high trans fat food. Design: Cross-sectional survey. Setting: An urban commuter college. Subjects: Two hundred twenty-two college students. Variables…

  18. Deuterium isotope effects in 13C NMR spectra of trans-azobenzene

    NASA Astrophysics Data System (ADS)

    Vikić-Topić, Draz̆en; Novak, Predrag; Smrec̆ki, Vilko; Meić, Zlatko

    1997-06-01

    Deuterium isotope effects on 13C chemical shifts have been determined in a series of deuteriated trans-azobenzene isotopomers. The longest effect observed is the one over ten bonds ( 10Δ) in 4- 2H-isotopomer at C-4' atom amounting to 3.3 ppb. The magnitude and the extent of isotope effects in trans-azobenzene are related to those observed in isoelectronic and conformationally similar trans-stilbene. The sign alternation pattern of the long-range isotope effects in trans-azobenzene parallels that in isoelectronic trans-stilbene, cis-stilbene and trans-N-benzylideneaniline.

  19. SAR changes in a human head model for plane wave exposure (500 - 2500 MHz) and a comparison with IEEE 2005 safety limits.

    PubMed

    Yelkenci, Tanju; Paker, Selcuk

    2008-01-01

    In this paper, external electric field values that are derived from the largest peak average 10 g SAR (Specific Absorption Rate) results in a realistic human head model are compared with current IEEE and ICNIRP reference levels. The head is illuminated by a plane wave source at seven different frequencies ranging from 500 MHz to 2500 MHz, with five different incident directions and three polarizations. Results reveal that the presence of metallic wire spectacles reduces the external electric field levels in the region above 900 MHz. Comparison of derived electric field values shows that the current IEEE and ICNIRP safety limits provide a conservative estimate.

  20. Unusually large secondary deuterium isotope effect. Thermal trans-cis isomerization of trans-1-phenylcyclohexene

    SciTech Connect

    Caldwell, R.A.; Misawa, H.; Healy, E.F.; Dewar, M.J.

    1987-01-01

    The magnitudes of secondary deuterium isotope effects (SDIE) are generally in the range of 0.9 < kH/kD < 1.25, and are often satisfactorily rationalized by the zero-point energy (ZPE) change on going from reactant to transition state due to C-H rehybridization. We now report a far larger SDIE for the title reaction. Its rationalization on the basis of transition-state theory suggests that it more closely resembles a primary isotope effect. Laser flash photolysis of cis-1-phenylcyclohexene (direct, 266 nm, or sensitized by thioxanthone, 355 nm) affords its trans isomer which in heptane exclusively reverts to 1, k = 2.1 x 10/sup 5/ s at 300 K. Isotopically substituted 2-2-d1 or 2-2,6-6-d3 (generated similarly from the corresponding cis isomers5) both have rates of reversion longer than 2 itself by a factor of 2.0 at room temperature. No previously reported SDIE approaches this magnitude.

  1. Trans fatty acids: has all the evidence been considered?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    High intakes of industrially-produced trans fatty acids (iTFA) have been shown to increase circulating low-density lipoprotein cholesterol (LDL-C) levels, which has implicated iTFA in coronary heart disease risk (CHD). Partially hydrogenated oils (PHO) became a predominant source of iTFA when marga...

  2. Teaching "Trans Issues": An Intersectional and Systems-Based Approach

    ERIC Educational Resources Information Center

    Boucher, Michel J.

    2011-01-01

    Transgender people are becoming increasingly visible in popular culture, academia, and national politics. University and college administrators are struggling at every level with how to address the needs of trans-identified staff people, faculty members, and students, all of whom are increasingly becoming open, vibrant participants in university…

  3. Trans-cis molecular photoswitching in interstellar space

    NASA Astrophysics Data System (ADS)

    Cuadrado, S.; Goicoechea, J. R.; Roncero, O.; Aguado, A.; Tercero, B.; Cernicharo, J.

    2016-11-01

    As many organic molecules, formic acid (HCOOH) has two conformers (trans and cis). The energy barrier to internal conversion from trans to cis is much higher than the thermal energy available in molecular clouds. Thus, only the most stable conformer (trans) is expected to exist in detectable amounts. We report the first interstellar detection of cis-HCOOH. Its presence in ultraviolet (UV) irradiated gas exclusively (the Orion Bar photodissociation region), with a low trans-to-cis abundance ratio of 2.8 ± 1.0, supports a photoswitching mechanism: a given conformer absorbs a stellar photon that radiatively excites the molecule to electronic states above the interconversion barrier. Subsequent fluorescent decay leaves the molecule in a different conformer form. This mechanism, which we specifically study with ab initio quantum calculations, was not considered in Space before but likely induces structural changes of a variety of interstellar molecules submitted to UV radiation. This paper makes use of observations obtained with the IRAM-30 m telescope. IRAM is supported by INSU/CNRS (France), MPG (Germany), and IGN (Spain).

  4. cis- and trans-Stilbenes: Chromatographic Separation and Photochemical Isomerization.

    ERIC Educational Resources Information Center

    Levine, Samuel G.; And Others

    1988-01-01

    Describes an experiment that is to be performed midway in the first semester of an undergraduate organic chemistry laboratory coinciding with the students' introduction to cis-trans isomerism in the study of alkenes. Discusses the apparatus, materials, experimental procedure, historical significance, and results. (CW)

  5. TELRI: Trans European Language Resources Infrastructure Newsletter, 1995-1997.

    ERIC Educational Resources Information Center

    TELRI: Trans European Language Resources Infrastructure Newsletter, 1997

    1997-01-01

    The first seven issues of the Trans European Language Resources Infrastructure (TELRI) newsletter, a publication of the COPERNICUS project funded by the Commission of the European Communities, date from September 1995 to October 1997. The first three issues contain articles in the origins of TELRI, its members, working groups, and events. TELRI's…

  6. Volcanic Hazards Survey in the Trans Mexican Volcanic Belt

    NASA Technical Reports Server (NTRS)

    Abrams, Michael; Siebe, Claus; Macias, Jose Luis

    1996-01-01

    We have assembled a digital mosaic of 11 Landsat Thematic images to serve as a mapping base for reconnaissance activities within the Trans Mexican Volcanic Belt. This will aid us in interpretation and in the evaluation of potential activity of all the volcanic centers there. One result is a volcanic hazards map of the area.

  7. Antitumor Trans Platinum Adducts of GMP and AMP

    PubMed Central

    Liu, Yangzhong; Sivo, Maria F.; Natile, Giovanni

    2000-01-01

    Recently it has been shown that several analogues of the clinically ineffective trans-DDP exhibit antitumor activity comparable to that of cis-DDP. The present paper describes the binding of antitumor trans-[PtCl2(E-iminoether)2] (trans-EE) to guanosinemonophosphate (GMP) and adenosinemonophosphate (AMP). We have used HPLC and 1H and 15N NMR to characterize the different adducts. In the case of a 1:1 mixture of trans-EE and GMP, at an early stage of the reaction, a monofunctional adduct is formed which, subsequently, is partly converted into a monosolvated monofunctional species. After about 70 hours an equilibrium is established between chloro and solvato monofunctional adducts at a ratio of 30/70. In the presence of excess GMP (4:1) the initially formed monofunctional adducts react further to give two bifunctional adducts, one with the iminoether ligands in their original E configurations and the other with the iminoether ligands having one E and the other, Z configurations. The coordination geometry obtained by energy minimization calculations is in qualitative agreement with 2D NMR data. PMID:18475942

  8. Saturated and trans fats and dementia: a systematic review.

    PubMed

    Barnard, Neal D; Bunner, Anne E; Agarwal, Ulka

    2014-09-01

    Cognitive disorders of later life are potentially devastating. To estimate the relationship between saturated and trans fat intake and risk of cognitive disorders. PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies reporting saturated or trans fat intake and incident dementia, Alzheimer's disease (AD), or mild cognitive impairment (MCI) or cognitive decline. Only observational studies met the inclusion criteria: 4 for AD or other dementias, 4 for MCI, and 4 for cognitive decline. Saturated fat intake was positively associated with AD risk in 3 of 4 studies, whereas the fourth suggested an inverse relationship. Saturated fat intake was also positively associated with total dementia in 1 of 2 studies, with MCI in 1 of 4 studies, and with cognitive decline in 2 of 4 studies. Relationships between trans fat intake and dementia were examined in 3 reports with mixed results. Several, although not all, prospective studies indicate relationships between saturated and trans fat intake and risk of cognitive disorders.

  9. Spliced-leader trans-splicing in freshwater planarians.

    PubMed

    Zayas, Ricardo M; Bold, Tyler D; Newmark, Phillip A

    2005-10-01

    trans-Splicing, in which a spliced-leader (SL) RNA is appended to the most 5' exon of independently transcribed pre-mRNAs, has been described in a wide range of eukaryotes, from protozoans to chordates. Here we describe trans-splicing in the freshwater planarian Schmidtea mediterranea, a free-living member of the phylum Platyhelminthes. Analysis of an expressed sequence tag (EST) collection from this organism showed that over 300 transcripts shared one of two approximately 35-base sequences (Smed SL-1 and SL-2) at their 5' ends. Examination of genomic sequences encoding representatives of these transcripts revealed that these shared sequences were transcribed elsewhere in the genome. RNA blot analysis, 5' and 3' rapid amplification of cDNA ends, as well as genomic sequence data showed that 42-nt SL sequences were derived from small RNAs of approximately 110 nt. Similar sequences were also found at the 5' ends of ESTs from the planarian Dugesia japonica. trans-Splicing has already been described in numerous representatives of the phylum Platyhelminthes (trematodes, cestodes, and polyclads); its presence in two representatives of the triclads supports the hypothesis that this mode of RNA processing is ancestral within this group. The upcoming complete genome sequence of S. mediterranea, combined with this animal's experimental accessibility and susceptibility to RNAi, provide another model organism in which to study the function of the still-enigmatic trans-splicing.

  10. Biosynthesis of polyketides by trans-AT polyketide synthases.

    PubMed

    Helfrich, Eric J N; Piel, Jörn

    2016-02-01

    This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides. The article includes 609 references and covers the literature from 2009 through June 2015.

  11. Biosynthesis of polyketides by trans-AT polyketide synthases.

    PubMed

    Piel, Jörn

    2010-07-01

    This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.

  12. An integrated PHY-MAC analytical model for IEEE 802.15.7 VLC network with MPR capability

    NASA Astrophysics Data System (ADS)

    Yu, Hai-feng; Chi, Xue-fen; Liu, Jian

    2014-09-01

    Considering that the collision caused by hidden terminal is particularly serious due to the narrow beams of optical devices, the multi-packet reception (MPR) is introduced to mitigate the collisions for IEEE 802.15.7 visible light communication (VLC) system. To explore the impact of MPR on system performance and investigate the interaction between physical (PHY) layer and media access control (MAC) layer, a three dimensional (3D) integrated PHY-MAC analytical model of carrier sense multiple access/collision avoidance (CSMA/CA) is established based on Markov chain theory for VLC system, in which MPR is implemented through the use of orthogonal code sequence. Throughput is derived to evaluate the performance of VLC system with MPR capability under imperfect optical channel. The results can be used for the performance optimization of a VLC system with MPR capability.

  13. Women in biomedical engineering and health informatics and its impact on gender representation for accepted publications at IEEE EMBC 2007.

    PubMed

    McGregor, Carolyn; Smith, Kathleen P; Percival, Jennifer

    2008-01-01

    The study of women within the professions of Engineering and Computer Science has consistently been found to demonstrate women as a minority within these professions. However none of that previous work has assessed publication behaviours based on gender. This paper presents research findings on gender distribution of authors of accepted papers for the IEEE Engineering and Medicine Society annual conference for 2007 (EMBC '07) held in Lyon, France. This information is used to present a position statement of the current state of gender representation for conference publication within the domain of biomedical engineering and health informatics. Issues in data preparation resulting from the lack of inclusion of gender in information gathered from accepted authors are presented and discussed.

  14. Wideband rhombic dielectric resonator antenna with CPW slot excitation for IEEE 802.11a/HiperLAN application

    NASA Astrophysics Data System (ADS)

    Dhar, Sayantan; Ghatak, Rowdra; Gupta, Bhaskar; Poddar, Dipak R.

    2013-09-01

    A wideband dielectric resonator antenna (DRA) using a CPW-fed inductive slot is proposed in this article. The DRA provides a simple design that exhibits a wide impedance bandwidth of about 26.8% (5.18-6.68 GHz). This is achieved by gradually rotating a square DRA by 45° to generate a rhombic DRA of dimensions 25 × 25 × 5 mm3. DRA structures with different rotation angles have also been studied to provide a comparative study into which orientation offers the best bandwidth. This structure results in the splitting up of the ? mode, and with suitable selection of the resonator dimensions, these modes can be brought close enough to yield wideband resonance characteristic. The proposed antenna has a realised gain of about 5.5 dBi over the entire band. The antenna covers the IEEE 802.11a, HiperLAN and UNII bands.

  15. IEEE 802.15.4 Frame Aggregation Enhancement to Provide High Performance in Life-Critical Patient Monitoring Systems.

    PubMed

    Akbar, Muhammad Sajjad; Yu, Hongnian; Cang, Shuang

    2017-01-28

    In wireless body area sensor networks (WBASNs), Quality of Service (QoS) provision for patient monitoring systems in terms of time-critical deadlines, high throughput and energy efficiency is a challenging task. The periodic data from these systems generates a large number of small packets in a short time period which needs an efficient channel access mechanism. The IEEE 802.15.4 standard is recommended for low power devices and widely used for many wireless sensor networks applications. It provides a hybrid channel access mechanism at the Media Access Control (MAC) layer which plays a key role in overall successful transmission in WBASNs. There are many WBASN's MAC protocols that use this hybrid channel access mechanism in variety of sensor applications. However, these protocols are less efficient for patient monitoring systems where life critical data requires limited delay, high throughput and energy efficient communication simultaneously. To address these issues, this paper proposes a frame aggregation scheme by using the aggregated-MAC protocol data unit (A-MPDU) which works with the IEEE 802.15.4 MAC layer. To implement the scheme accurately, we develop a traffic patterns analysis mechanism to understand the requirements of the sensor nodes in patient monitoring systems, then model the channel access to find the performance gap on the basis of obtained requirements, finally propose the design based on the needs of patient monitoring systems. The mechanism is initially verified using numerical modelling and then simulation is conducted using NS2.29, Castalia 3.2 and OMNeT++. The proposed scheme provides the optimal performance considering the required QoS.

  16. IEEE 802.15.4 Frame Aggregation Enhancement to Provide High Performance in Life-Critical Patient Monitoring Systems

    PubMed Central

    Akbar, Muhammad Sajjad; Yu, Hongnian; Cang, Shuang

    2017-01-01

    In wireless body area sensor networks (WBASNs), Quality of Service (QoS) provision for patient monitoring systems in terms of time-critical deadlines, high throughput and energy efficiency is a challenging task. The periodic data from these systems generates a large number of small packets in a short time period which needs an efficient channel access mechanism. The IEEE 802.15.4 standard is recommended for low power devices and widely used for many wireless sensor networks applications. It provides a hybrid channel access mechanism at the Media Access Control (MAC) layer which plays a key role in overall successful transmission in WBASNs. There are many WBASN’s MAC protocols that use this hybrid channel access mechanism in variety of sensor applications. However, these protocols are less efficient for patient monitoring systems where life critical data requires limited delay, high throughput and energy efficient communication simultaneously. To address these issues, this paper proposes a frame aggregation scheme by using the aggregated-MAC protocol data unit (A-MPDU) which works with the IEEE 802.15.4 MAC layer. To implement the scheme accurately, we develop a traffic patterns analysis mechanism to understand the requirements of the sensor nodes in patient monitoring systems, then model the channel access to find the performance gap on the basis of obtained requirements, finally propose the design based on the needs of patient monitoring systems. The mechanism is initially verified using numerical modelling and then simulation is conducted using NS2.29, Castalia 3.2 and OMNeT++. The proposed scheme provides the optimal performance considering the required QoS. PMID:28134853

  17. Reviewing Consensus HFE Standards for NRC Use: A Case Study using the IEEE Standard for Computerized Operating Procedure Systems

    SciTech Connect

    OHara, J.M.; Higgins, J.; Xing, J., Fleger S. - NRC

    2010-11-07

    The U.S. Nuclear Regulatory Commission’s (NRC’s) endorsement of consensus standards provides a cost-effective means of enhancing the staff’s ability to review state-of-the-art designs. Although the NRC endorsed consensus standards in many technical disciplines, it yet has to do so in human factors engineering (HFE). The purpose of our study was to develop a standardized methodology whereby to evaluate a consensus HFE standard to determine its appropriateness to, and adequacy for using in licensing reviews. The high-level objective of the methodology is to ensure that the guidance meets the NRC’s requirements on scientific- and engineering-rigor that they use in developing their own guidance. We propose four criteria for endorsing a consensus standard: (1) It should meet an existing need for NRC’s licensing and safety reviews; (2) it should be based on sound HFE principles; (3) it should be thoroughly peer-reviewed; and, (4) it should address human performance issues identified in the literature. Our methodology offers a means to assess these four criteria. We used it to evaluate an Institute of Electrical and Electronics Engineers’ (IEEE) draft standard on computerized operating procedure systems. We concluded that the IEEE standard generally met the established criteria, although several areas were identified that needed further clarification. Our evaluation methodology particularly was useful for identifying issues to be resolved, and for providing a basis for judging whether the staff should consider endorsing the standard. The methodology also helped recognize criteria in the proposed standard that may benefit from additional scrutiny by the staff. The evaluation methodology developed is applicable generally to reviewing other HFE standards that the NRC is considering for use or endorsement.

  18. Trans-system mechanisms against ischemic myocardial injury.

    PubMed

    Liu, Shu Q; Ma, Xin-Liang; Qin, Gangjian; Liu, Qingping; Li, Yan-Chun; Wu, Yu H

    2015-01-01

    A mammalian organism possesses a hierarchy of naturally evolved protective mechanisms against ischemic myocardial injury at the molecular, cellular, and organ levels. These mechanisms comprise regional protective processes, including upregulation and secretion of paracrine cell-survival factors, inflammation, angiogenesis, fibrosis, and resident stem cell-based cardiomyocyte regeneration. There are also interactive protective processes between the injured heart, circulation, and selected remote organs, defined as trans-system protective mechanisms, including upregulation and secretion of endocrine cell-survival factors from the liver and adipose tissue as well as mobilization of bone marrow, splenic, and hepatic cells to the injury site to mediate myocardial protection and repair. The injured heart and activated remote organs exploit molecular and cellular processes, including signal transduction, gene expression, cell proliferation, differentiation, migration, mobilization, and/or extracellular matrix production, to establish protective mechanisms. Both regional and trans-system cardioprotective mechanisms are mediated by paracrine and endocrine messengers and act in coordination and synergy to maximize the protective effect, minimize myocardial infarction, and improve myocardial function, ensuring the survival and timely repair of the injured heart. The concept of the trans-system protective mechanisms may be generalized to other organ systems-injury in one organ may initiate regional as well as trans-system protective responses, thereby minimizing injury and ensuring the survival of the entire organism. Selected trans-system processes may serve as core protective mechanisms that can be exploited by selected organs in injury. These naturally evolved protective mechanisms are the foundation for developing protective strategies for myocardial infarction and injury-induced disorders in other organ systems.

  19. Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers.

    PubMed

    Yugi, Katsuyuki; Kubota, Hiroyuki; Hatano, Atsushi; Kuroda, Shinya

    2016-04-01

    We propose 'trans-omic' analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.

  20. Potentially toxic elements (PTEs) in soils from the surroundings of the Trans-Amazonian Highway, Brazil.

    PubMed

    de Souza, Edna Santos; Fernandes, Antonio Rodrigues; de Souza Braz, Anderson Martins; Sabino, Lorena Lira Leite; Alleoni, Luís Reynaldo Ferracciú

    2015-01-01

    The Trans-Amazonian Highway (TAH) is located in the northern region of Brazil, comprising a border region where agricultural, mining, and logging activities are the main activities responsible for fostering economic development, in addition to large hydroelectric plants. Such activities lead to environmental contamination by potentially toxic elements (PTEs). Environmental monitoring is only possible through the determination of element contents under natural conditions. Many extraction methods have been proposed to determine PTEs' bioavailability in the soil; however, there is no consensus about which extractor is most suitable. In this study, we determined the contents of PTEs in soils in the surroundings of TAH after mineral extraction with diethylenetriaminepentaacetic acid-triethanolamine (DTPA-TEA), Mehlich I, and Mehlich III solutions. Soil samples were collected in areas of natural vegetation in the vicinity of TAH in the state of Pará, Brazil. Chemical attributes and particle size were determined, besides concentrations of Fe, Al, Mn, and Ti by sulfuric acid digestion, Si after alkaline solution attack, and poorly crystalline Fe, Al, and "free" Fe oxides. Mehlich III solution extracted greater contents from Fe, Al, and Pb as compared to Mehlich I and DTPA-TEA and similar contents from Cd, Mn, Zn, and Cu. Significant correlations were found between concentrations of PTEs and the contents of Fe and Mn oxides as well as organic carbon and soil cation exchange capacity. Contents of Cu, Mn, Fe, and Zn by the three methods were positively correlated.

  1. Understanding field variation, quantum chemical modeling and molecular orbital analyses of trans-3-(trans-4-imidazolyl) acrylic acid

    NASA Astrophysics Data System (ADS)

    Gayathri, R.; Arivazhagan, M.

    2017-02-01

    In this work, a joint experimental (FTIR and FT-Raman) and theoretical (DFT and ab-initio) study on the structure and the vibrations of Trans-3-(trans-4-imidazolyl) acrylic acid (TTIAA) are compared and analyzed. The assignment of each normal mode has been made using the observed and calculated frequencies. The optimized geometries, harmonic vibrational wavenumbers and intensities of vibrational bands of trans-3-(trans-4-imidazolyl) acrylic acid (TTIAA) have been carried out using the HF/B3LYP method using the standard 6311++G(d,p) basis set calculations in this investigation. The result describes the variation in electrostatic and transport properties for zero and various external applied field. The variation in MPA charges are small due to the application of EFs: however, in most cases it is found to be systematic and almost uniform. When the field increases from 0.00 to 0.02 VÅ-1, the hybridization of molecular levels broadens the DOS and decreases the HLG from 3.6609 to 1.2325 eV; the decrease of band gap at the high field indicates that this molecule exhibit considerable electrical conductivity. Fukui indices to determine the local reactive site for the molecular systems during electrophilic, nucleophilic, radical and dual descriptor attacks. The results clearly show the superiority of MPA scheme. This study may be useful to design new molecules with more electrical conductivity.

  2. "It's a Hard Line to Walk": Black Non-Binary Trans* Collegians' Perspectives on Passing, Realness, and Trans*-Normativity

    ERIC Educational Resources Information Center

    Nicolazzo, Z.

    2016-01-01

    Being labeled as "abnormal, or deviant, or not being one of the rest of us" has real effects for one's life chances. Trans* people are one such group who have continually been codified as abnormal, abject, weird, deceptive, and social pariahs. The purpose of the following study was to explore how the concepts of passing, realness, and…

  3. Proceeding of the ACM/IEEE-CS Joint Conference on Digital Libraries (1st, Roanoke, Virginia, June 24-28, 2001).

    ERIC Educational Resources Information Center

    Association for Computing Machinery, New York, NY.

    Papers in this Proceedings of the ACM/IEEE-CS Joint Conference on Digital Libraries (Roanoke, Virginia, June 24-28, 2001) discuss: automatic genre analysis; text categorization; automated name authority control; automatic event generation; linked active content; designing e-books for legal research; metadata harvesting; mapping the…

  4. IEEE Conference on Software Engineering Education and Training (CSEE&T 2012) Proceedings (25th, Nanjing, Jiangsu, China, April 17-19, 2012)

    ERIC Educational Resources Information Center

    IEEE Conference on Software Engineering Education and Training, Proceedings (MS), 2012

    2012-01-01

    The Conference on Software Engineering Education and Training (CSEE&T) is the premier international peer-reviewed conference, sponsored by the Institute of Electrical and Electronics Engineers, Inc. (IEEE) Computer Society, which addresses all major areas related to software engineering education, training, and professionalism. This year, as…

  5. IEEE Validation of the Continuing Education Achievement of Engineers Registry System. Procedures for Use with a CPT 8000 Word Processor and Communications Package.

    ERIC Educational Resources Information Center

    Institute of Electrical and Electronics Engineers, Inc., New York, NY.

    The Institute of Electrical and Electronics Engineers (IEEE) validation program is designed to motivate persons practicing in electrical and electronics engineering to pursue quality technical continuing education courses offered by any responsible sponsor. The rapid acceptance of the validation program necessitated the additional development of a…

  6. A neutralizing monoclonal antibody previously mapped exclusively on human immunodeficiency virus type 1 gp41 recognizes an epitope in p17 sharing the core sequence IEEE.

    PubMed Central

    Buratti, E; Tisminetzky, S G; D'Agaro, P; Baralle, F E

    1997-01-01

    We report here that a human immunodeficiency virus type 1 (HIV-1)-specific neutralizing monoclonal antibody (MAb 1575) mapped to the conserved putative intracellular region from amino acid residues 735 to 752 (735-752 region) of gp41 also recognizes a region in an extracellular portion of p17. Both epitopes have a core recognition sequence (IEEE) in a nonhomologous context. The IEEE motif found in HIV-1 p17 is located in a region known as HGP-30 (residues 86 to 115) which has been previously associated with virus neutralization, cytotoxic T lymphocyte activity, and mother-to-child transmission. An analysis of available gp41 and p17 sequences demonstrates that in these regions both IEEE sequences are highly conserved in different HIV-1 clades. The presence of the IEEE epitope in p17 allows us to explain some unexpected neutralizing characteristics of MAb 1575. In addition, the gp41 735-752 region has been previously reported both in intra- and extracellular locations. Our results suggest that the extracellular location was the result of cross-reactivity with p17. PMID:9032383

  7. Comparing Trans-Spectrum and Same-Sex-Attracted Youth in Australia: Increased Risks, Increased Activisms

    ERIC Educational Resources Information Center

    Jones, Tiffany; Hillier, Lynne

    2013-01-01

    Tran-spectrum youth include those who are gender questioning, transgender, intersex, genderqueer, and androgynous. Drawing on data from an Australian study of more than 3,000 same-sex-attracted and trans-spectrum youth aged 14 to 21, this article compares a group of 91 trans-spectrum youth from the study to "cisgender" same-sex-attracted…

  8. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli

    PubMed Central

    2014-01-01

    Background Trans-4-hydroxy-L-proline (trans-Hyp), one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals. Although there are some natural biosynthetic pathways of trans-Hyp existing in microorganisms, the yield is still too low to be scaled up for industrial applications. Until now the production of trans-Hyp is mainly from the acid hydrolysis of collagen. Due to the increasing environmental concerns on those severe chemical processes and complicated downstream separation, it is essential to explore some environment-friendly processes such as constructing new recombinant strains to develop efficient process for trans-Hyp production. Result In this study, the genes of trans-proline 4-hydroxylase (trans-P4H) from diverse resources were cloned and expressed in Corynebacterium glutamicum and Escherichia coli, respectively. The trans-Hyp production by these recombinant strains was investigated. The results showed that all the genes from different resources had been expressed actively. Both the recombinant C. glutamicum and E. coli strains could produce trans-Hyp in the absence of proline and 2-oxoglutarate. Conclusions The whole cell microbial systems for trans-Hyp production have been successfully constructed by introducing trans-P4H into C. glutamicum and E. coli. Although the highest yield was obtained in recombinant E. coli, using recombinant C. glutamicum strains to produce trans-Hyp was a new attempt. PMID:24885047

  9. "It Will Change if People Keep Talking": Trans* Students in College and University Housing

    ERIC Educational Resources Information Center

    Nicolazzo, Z.; Marine, Susan B.

    2015-01-01

    Trans* individuals have recently received greater attention in mainstream media. Trans* students and their concerns are also becoming more visible, as evidenced by the recent increase in the number of colleges and universities that are offering trans*-inclusive housing options. However, such increased visibility does not readily equate to…

  10. The Electronic Properties of AlN Tunnel Barriers and the Effect of Oxygen Impurities

    NASA Astrophysics Data System (ADS)

    Li, Yun; Read, John; Huang, Pinshane; Tseng, Hsin-Wei; Buhrman, Robert

    2009-03-01

    The use of ultra-thin aluminum nitride (AlN) barrier layers can result in Josephson Junctions (JJ's) with both very high critical current densities and low sub-gap leakage [1-4], demonstrating that AlN is a superior JJ tunnel barrier material in the ultra-thin barrier limit. We have utilized scanning tunneling spectroscopy (STS) and analytical scanning transmission electron microscopy (STEM) with electron energy-loss spectroscopy (EELS) to investigate thin AlN layers formed on Nb/Al bilayers by treating the Al surface with an atomic nitrogen beam. Under optimum nitridation conditions the resultant ˜1nm AlN barrier layers have small, ˜ 1 eV, but well defined band gaps and stable surfaces in UHV, with the absence of band-tail states extending close to the Fermi energy, which is in sharp contrast to the case for AlOx layers formed by thermal oxidation [5]. The AlN barrier layers are however quite sensitive to even low levels of background oxygen (O) exposure, either during or after the nitridation process, which reacts O into the barrier layer and results in the formation of low energy band-tail states and an unstable surface. [1] Zijlstra et al., APL 91, 233102 (2007); [2] Wang et al., APL 64, 2034 (1994); [3] Kleinsasser et al., IEEE TAS 5, 2318 (1995); [4] Kaul et al., JMRS 20, 3047 (2005); [5] Mather et al., APL 86, 242504 (2005)

  11. Earth Return Aerocapture for the TransHab/Ellipsled Vehicle

    NASA Technical Reports Server (NTRS)

    Muth, W. D.; Hoffmann, C.; Lyne, J. E.

    2000-01-01

    The current architecture being considered by NASA for a human Mars mission involves the use of an aerocapture procedure at Mars arrival and possibly upon Earth return. This technique would be used to decelerate the vehicles and insert them into their desired target orbits, thereby eliminating the need for propulsive orbital insertions. The crew may make the interplanetary journey in a large, inflatable habitat known as the TransHab. It has been proposed that upon Earth return, this habitat be captured into orbit for use on subsequent missions. In this case, the TransHab would be complimented with an aeroshell, which would protect it from heating during the atmospheric entry and provide the vehicle with aerodynamic lift. The aeroshell has been dubbed the "Ellipsled" because of its characteristic shape. This paper reports the results of a preliminary study of the aerocapture of the TransHab/Ellipsled vehicle upon Earth return. Undershoot and overshoot boundaries have been determined for a range of entry velocities, and the effects of variations in the atmospheric density profile, the vehicle deceleration limit, the maximum vehicle roll rate, the target orbit, and the vehicle ballistic coefficient have been examined. A simple, 180 degree roll maneuver was implemented in the undershoot trajectories to target the desired 407 km circular Earth orbit. A three-roll sequence was developed to target not only a specific orbital energy, but also a particular inclination, thereby decreasing propulsive inclination changes and post-aerocapture delta-V requirements. Results show that the TransHab/Ellipsled vehicle has a nominal corridor width of at least 0.7 degrees for entry speeds up to 14.0 km/s. Most trajectories were simulated using continuum flow aerodynamics, but the impact of high-altitude viscous effects was evaluated and found to be minimal. In addition, entry corridor comparisons have been made between the TransHab/Ellipsled and a modified Apollo capsule which is also

  12. Ionization energy and active cation vibrations of trans-2-fluorostyrene

    NASA Astrophysics Data System (ADS)

    Wu, Pei Ying; Tzeng, Sheng Yuan; Hsu, Ya Chu; Tzeng, Wen Bih

    2017-02-01

    We applied the two-color resonant two-photon mass-analyzed threshold ionization (MATI) technique to record the cation spectra of trans-2-fluorostyrene by ionizing via six intermediate vibronic levels. The adiabatic ionization energy was determined to be 69 304 ± 5 cm-1. The distinct MATI bands at 67, 124, 242, 355, 737, 806, 833, and 993 cm-1 were assigned to the active cation vibrations related to out-of-plane substituent-sensitive bending vibrations and in-plane ring deformation and bending motions. Many combination vibrations were also observed. Our experimental results suggest that the molecular geometry and vibrational coordinates of the trans-2-fluorostyrene cation in the D0 state resemble those of the neutral species in the S1 state.

  13. trans-Activation of a globin promoter in nonerythroid cells.

    PubMed Central

    Evans, T; Felsenfeld, G

    1991-01-01

    We show that expression in fibroblasts of a single cDNA, encoding the erythroid DNA-binding protein Eryf1 (GF-1, NF-E1), very efficiently activates transcription of a chicken alpha-globin promoter, trans-Activation in these cells occurred when Eryf1 bound to a single site within a minimal globin promoter. In contrast, efficient activation in erythroid cells required multiple Eryf1 binding sites. Our results indicate that mechanisms exist that are capable of modulating the trans-acting capabilities of Eryf1 in a cell-specific manner, without affecting DNA binding. The response of the minimal globin promoter to Eryf1 in fibroblasts was at least as great as for optimal constructions in erythroid cells. Therefore, the assay provides a very simple and sensitive system with which to study gene activation by a tissue-specific factor. Images PMID:1990287

  14. Experiences of female partners of masculine identifying trans persons

    PubMed Central

    Theron, Liesl; Collier, Kate L.

    2013-01-01

    This study explores the intimate relationship experiences of cisgender (i.e., not transgender) female partners of masculine identifying transgender persons, with a particular focus on these partners’ self-understanding of their sexual orientation. Limited research about this topic has been conducted to date. Semi-structured interviews were conducted with eight South African women who are or have been cisgender female partners of masculine identifying trans persons. Although the interviews showed that the relationship experiences of female partners of masculine identifying trans persons are diverse, several common themes emerged in the narratives. The way that participants labelled their sexual orientation did not change from before to after their relationship with a transgender partner. The participants reported varied family and community responses to their relationships. Specific emotional and informational support needs for women with transgender partners were identified. PMID:23668602

  15. The charge-transfer complex trans-STB-TCNQF4.

    PubMed

    Sato, A; Okada, M; Saito, K; Sorai, M

    2001-05-01

    In the crystal structure of the title charge-transfer complex, namely trans-stilbene-2,2'-(2,3,5,6-tetrafluorobenzene-1,4-diylidene)propanedinitrile (1/1) (trans-STB-TCNQF(4)), C(14)H(12).C(12)F(4)N(4), the planar STB and TCNQF(4) molecules are stacked alternately. The structure is not isostructural with that of STB-TCNQ. No anomaly was found in the displacement parameters of any atoms, while the bond length of the central C=C moiety was shorter than the corresponding bond in ethylene. This suggests that the central C=C moiety of the STB molecule vibrates with a large amplitude, similar to the case in free STB and STB-TCNQ.

  16. She's always a woman: Butch lesbian trans women in the lesbian community.

    PubMed

    Rossiter, Hannah

    2016-01-01

    While the visibility and acceptance of trans women have grown globally in recent years, this progress has primarily been within a traditional, heteronormative narrative. But a growing number of trans women identify as butch lesbians and challenge this heteronormative narrative. The existence of butch trans women has created a debate on where they fit within queer and lesbian communities and how their gender performance fits within traditional butch/femme understandings of lesbian or queer relationships. This article seeks to explore the intersections of gender identity and sexual orientation that butch trans women experience when they engage with lesbian and trans communities.

  17. Regen compressors power Capo Bon trans-med station

    SciTech Connect

    de Biasi, V.

    1981-11-01

    It is expected that Algeria will begin deliveries of natural gas from the Hassi-R'Mel gasfield in the Sahara Desert to Italy by the end of 1981 or early 1982. The main station for the Trans-Med natural gas pipeline, powered by five regenerative M5322R gas turbines, has a design throughput of some 1.6 million m/sup 3//hr and serves as the boost station for the submarine section of the pipeline.

  18. A Mechanism by Which Dietary Trans Fats Cause Atherosclerosis*

    PubMed Central

    Chen, Chun-Lin; Tetri, Laura H.; Neuschwander-Tetri, Brent A.; Huang, Shuan Shian; Huang, Jung San

    2010-01-01

    Dietary trans fats have been causally linked to atherosclerosis but the mechanism by which they cause the disease remain elusive. Suppressed TGF-β responsiveness in aortic endothelium has been shown to play an important role in the pathogenesis of atherosclerosis in animals with hypercholesterolemia. We investigated the effects of a high trans-fat (TF) diet on TGF-β responsiveness in aortic endothelium and integration of cholesterol in tissues. Here we show that normal mice fed a high TF diet for 24 weeks exhibit atherosclerotic lesions and suppressed TGF-β responsiveness in aortic endothelium. The suppressed TGF-β responsiveness is evidenced by markedly reduced expression of TGF-β type I and II receptors and profoundly decreased levels of P-Smad2, an important TGF-β–response indicator, in aortic endothelium. These mice exhibit greatly increased integration of cholesterol into tissue plasma membranes. These results suggest that dietary trans fats cause atherosclerosis, at least in part, by suppressing TGF-β responsiveness. This effect is presumably mediated by the increased deposition of cholesterol into cellular plasma membranes in vascular tissue, as in hypercholesterolemia. PMID:21036587

  19. Resolving conflicts over trans-boundary rivers using bankruptcy methods

    NASA Astrophysics Data System (ADS)

    Zarezadeh, M.; Madani, K.; Morid, S.

    2013-11-01

    A bankruptcy approach is proposed for resolving trans-boundary rivers conflicts in which the total water demand or claim of the riparian parties is more than the available water. Bankruptcy solution methods can allocate the available water to the conflicting parties with respect to their claims. Four bankruptcy rules are used here to allocate the available water to the riparian parties. Given the non-uniform spatial and temporal distribution of water across river basins, bankruptcy optimization models are proposed to allocate water based on these rules with respect to time sensitivity of water deliveries during the planning horizon. Once allocation solutions are developed, their acceptability and stability must be evaluated. Thus, a new stability index method is developed for evaluating the acceptability of bankruptcy solutions. To show how the bankruptcy framework can be helpful in practice, the suggested methods are applied to a real-world tarns-boundary river system with eight riparians under various hydrologic regimes. Stability analysis based on the proposed stability index method suggests that the acceptability of allocation rules is sensitive to hydrologic conditions and demand values. This finding has an important policy implication suggesting that fixed allocation rules and trans-boundary treaties may not be reliable for securing cooperation over trans-boundary water resources as they are vulnerable to changing socio-economic and climatic conditions as well as hydrologic non-stationarity.

  20. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.

    PubMed

    Shi, Wanliang; Zhang, Xuelian; Jiang, Xin; Yuan, Haiming; Lee, Jong Seok; Barry, Clifton E; Wang, Honghai; Zhang, Wenhong; Zhang, Ying

    2011-09-16

    Pyrazinamide (PZA) is a first-line tuberculosis drug that plays a unique role in shortening the duration of tuberculosis chemotherapy. PZA is hydrolyzed intracellularly to pyrazinoic acid (POA) by pyrazinamidase (PZase, encoded by pncA), an enzyme frequently lost in PZA-resistant strains, but the target of POA in Mycobacterium tuberculosis has remained elusive. Here, we identify a previously unknown target of POA as the ribosomal protein S1 (RpsA), a vital protein involved in protein translation and the ribosome-sparing process of trans-translation. Three PZA-resistant clinical isolates without pncA mutation harbored RpsA mutations. RpsA overexpression conferred increased PZA resistance, and we confirmed that POA bound to RpsA (but not a clinically identified ΔAla mutant) and subsequently inhibited trans-translation rather than canonical translation. Trans-translation is essential for freeing scarce ribosomes in nonreplicating organisms, and its inhibition may explain the ability of PZA to eradicate persisting organisms.

  1. TransFlip Mutations Produce Deletions in Pancreatic Cancer

    PubMed Central

    Norris, Alexis L.; Kamiyama, Hirohiko; Makohon-Moore, Alvin; Pallavajjala, Aparna; Morsberger, Laura A.; Lee, Kurt; Batista, Denise; Iacobuzio-Donahue, Christine A.; Lin, Ming-Tseh; Klein, Alison P.; Hruban, Ralph H.; Wheelan, Sarah J.; Eshleman, James R.

    2016-01-01

    Pancreatic ductal adenocarcinoma (PDAC) is driven by the inactivation of the tumor suppressor genes (TSGs), CDKN2A (P16) and SMAD4 (DPC4), commonly by homozygous deletions (HDs). Using a combination of high density single-nucleotide polymorphism (SNP) microarray and whole genome sequencing (WGS), we fine-mapped novel breakpoints surrounding deletions of CDKN2A and SMAD4 and characterized them by their underlying structural variants (SVs). Only one third of CDKN2A and SMAD4 deletions (6 of 18) were simple interstitial deletions, rather, the majority of deletions were caused by complex rearrangements, specifically, a translocation on one side of the TSG in combination with an inversion on the other side. We designate these as “TransFlip” mutations. Characteristics of TransFlip mutations are: (1) a propensity to target the TSGs CDKN2A and SMAD4 (P < 0.005), (2) not present in the germline of the examined samples, (3) non-recurrent breakpoints, (4) relatively small (47 bp to 3.4 kb) inversions, (5) inversions can be either telomeric or centromeric to the TSG, and (6) non-reciprocal, and non-recurrent translocations. TransFlip mutations are novel complex genomic rearrangements with unique breakpoint signatures in pancreatic cancer. We hypothesize that they are a common but poorly understood mechanism of TSG inactivation in human cancer. PMID:26031834

  2. TransFit: Finite element analysis data fitting software

    NASA Technical Reports Server (NTRS)

    Freeman, Mark

    1993-01-01

    The Advanced X-Ray Astrophysics Facility (AXAF) mission support team has made extensive use of geometric ray tracing to analyze the performance of AXAF developmental and flight optics. One important aspect of this performance modeling is the incorporation of finite element analysis (FEA) data into the surface deformations of the optical elements. TransFit is software designed for the fitting of FEA data of Wolter I optical surface distortions with a continuous surface description which can then be used by SAO's analytic ray tracing software, currently OSAC (Optical Surface Analysis Code). The improved capabilities of Transfit over previous methods include bicubic spline fitting of FEA data to accommodate higher spatial frequency distortions, fitted data visualization for assessing the quality of fit, the ability to accommodate input data from three FEA codes plus other standard formats, and options for alignment of the model coordinate system with the ray trace coordinate system. TransFit uses the AnswerGarden graphical user interface (GUI) to edit input parameters and then access routines written in PV-WAVE, C, and FORTRAN to allow the user to interactively create, evaluate, and modify the fit. The topics covered include an introduction to TransFit: requirements, designs philosophy, and implementation; design specifics: modules, parameters, fitting algorithms, and data displays; a procedural example; verification of performance; future work; and appendices on online help and ray trace results of the verification section.

  3. Overview of local, state, and national government legislation restricting trans fats.

    PubMed

    Assaf, Raymen R

    2014-03-01

    Trans fats, also known as partially hydrogenated oils, have long been associated with cardiovascular disease. In 2003, the Food and Drug Administration mandated that trans fat content of ≥0.5 g be listed on food labeling; the next year, the World Health Organization released a recommended daily limit on trans fat intake. During the following decade, legislatures in different municipal and state governments moved trans fat regulation forward, whereas many food companies decided to independently phase out trans fat in their products. The advancement of these parallel processes suggests an emerging best practices phenomenon, integrating public health, law, and the food industry. With both legislation and markets seemingly favoring a limitation on trans fat content in foods, attention has once again shifted to the Food and Drug Administration for a ruling on the safety of trans fats.

  4. NASA/IEEE MSST 2004 Twelfth NASA Goddard Conference on Mass Storage Systems and Technologies in cooperation with the Twenty-First IEEE Conference on Mass Storage Systems and Technologies

    NASA Technical Reports Server (NTRS)

    Kobler, Ben (Editor); Hariharan, P. C. (Editor)

    2004-01-01

    MSST2004, the Twelfth NASA Goddard / Twenty-first IEEE Conference on Mass Storage Systems and Technologies has as its focus long-term stewardship of globally-distributed storage. The increasing prevalence of e-anything brought about by widespread use of applications based, among others, on the World Wide Web, has contributed to rapid growth of online data holdings. A study released by the School of Information Management and Systems at the University of California, Berkeley, estimates that over 5 exabytes of data was created in 2002. Almost 99 percent of this information originally appeared on magnetic media. The theme for MSST2004 is therefore both timely and appropriate. There have been many discussions about rapid technological obsolescence, incompatible formats and inadequate attention to the permanent preservation of knowledge committed to digital storage. Tutorial sessions at MSST2004 detail some of these concerns, and steps being taken to alleviate them. Over 30 papers deal with topics as diverse as performance, file systems, and stewardship and preservation. A number of short papers, extemporaneous presentations, and works in progress will detail current and relevant research on the MSST2004 theme.

  5. Starch plus sunflower oil addition to the diet of dry dairy cows results in a trans-11 to trans-10 shift of biohydrogenation.

    PubMed

    Zened, A; Enjalbert, F; Nicot, M C; Troegeler-Meynadier, A

    2013-01-01

    Trans fatty acids (FA), exhibit different biological properties. Among them, cis-9,trans-11 conjugated linoleic acid has some interesting putative health properties, whereas trans-10,cis-12 conjugated linoleic acid has negative effects on cow milk fat production and would negatively affect human health. In high-yielding dairy cows, a shift from trans-11 to trans-10 pathway of biohydrogenation (BH) can occur in the rumen of cows receiving high-concentrate diets, especially when the diet is supplemented with unsaturated fat sources. To study this shift, 4 rumen-fistulated nonlactating Holstein cows were assigned to a 4×4 Latin square design with 4 different diets during 4 periods. Cows received 12 kg of dry matter per day of 4 diets based on corn silage during 4 successive periods: a control diet (22% starch, <3% crude fat on DM basis), a high-starch diet supplemented with wheat plus barley (35% starch, <3% crude fat), a sunflower oil diet supplemented with 5% of sunflower oil (20% starch, 7.6% crude fat), and a high-starch plus sunflower oil diet (33% starch, 7.3% crude fat). Five hours after feeding, proportions of trans-11 BH isomers greatly increased in the rumen content with the addition of sunflower oil, without change in ruminal pH compared with the control diet. Addition of starch to the control diet had no effect on BH pathways but decreased ruminal pH. The addition of a large amount of starch in association with sunflower oil increased trans-10 FA at the expense of trans-11 FA in the rumen content, revealing a trans-11 to trans-10 shift. Interestingly, with this latter diet, ruminal pH did not change compared with a single addition of starch. This trans-11 to trans-10 shift occurred progressively, after a decrease in the proportion of trans-11 FA in the rumen, suggesting that this shift could result from a dysbiosis in the rumen in favor of trans-10-producing bacteria at the expense of those producing trans-11 or a modification of bacterial activities.

  6. Ab initio spectroscopy and photoinduced cooling of the trans-stilbene molecule.

    PubMed

    Tatchen, Jörg; Pollak, Eli

    2008-04-28

    We present a theoretical study of the S(0)-->S(1) and S(0)<--S(1) vibronic spectra for trans-stilbene. Franck-Condon spectra in the harmonic approximation are generated for the complete system with 72 degrees of freedom by means of an analytic time-dependent approach accounting for Dushinsky rotations and thermal effects. The force fields are computed by means of density functional theory (DFT) and time-dependent DFT, on the one hand, and ab initio complete active space self-consistent field theory, on the other hand. The B3LYP functional shows that almost planar potential energy surface minima are found for the S(0) and S(1) state. Imposing C(2h) symmetry constraints, we obtain low-temperature high-resolution Franck-Condon spectra for both absorption and emission which are in reasonably good agreement with the experimental spectra measured by Syage et al. [J. Chem. Phys. 81, 4685 (1984)] in supersonic jets. Due to thermal population of low-energy modes, the room temperature absorption spectrum is very broad. An almost structureless band which extends over several thousand cm(-1) is obtained from the present theory and agrees with the experimental absorption band shape. Finally, within the harmonic model, we study the effect of photoexcitation on the energy distribution in the excited S(1) state. We find noticeable cooling of approximately 20 K within a frequency interval spanning from -400 to 200 cm(-1) around the 0-0 transition. This indicates that photoinduced cooling must be taken into account when considering the dynamics of the photoinduced isomerization of trans-stilbene. Moreover, this is not the final word, as anharmonicity of the low frequency modes must be taken into account to obtain a full picture which would explain both the energy dependence of the isomerization rates as well as the dependence on the pressure of an external buffer gas.

  7. Isolation and identification of trans-2- and trans-3-hydroxy-1,8-cineole glucosides from Alpinia galanga.

    PubMed

    Someya, Y; Kobayashi, A; Kubota, K

    2001-04-01

    Three hydroxy-1,8-cineole glucopyranosides, (1R, 2R, 4S)- and (1S, 2S, 4R)-trans-2-hydroxy-1,8-cineole beta-D-glucopyranosides, and (1R, 3S, 4S)-trans-3-hydroxy-1,8-cineole beta-D-glucopyranoside, which are possible precursors of acetoxy-1,8-cineoles as unique aroma components, were isolated from the rhizomes of greater galangal (Alpinia galanga W.). Their structures were analyzed by FAB-MS and NMR spectrometry, and the absolute configulation of each aglycone was determined by using a GC-MS analysis with a capillary column coated with a chiral stationary phase. The composition of the diastereomers of (1R, 2R, 4S)- and (1S, 2S, 4R)-trans-2-hydroxy-1,8-cineole beta-D-glucopyranosides in the rhizomes was determined as 3:7 by a GC-MS analysis after preparing the trifluoroacetate derivatives of the glucosides.

  8. AlInAsSb/GaSb staircase avalanche photodiode

    NASA Astrophysics Data System (ADS)

    Ren, Min; Maddox, Scott; Chen, Yaojia; Woodson, Madison; Campbell, Joe C.; Bank, Seth

    2016-02-01

    Over 30 years ago, Capasso and co-workers [IEEE Trans. Electron Devices 30, 381 (1982)] proposed the staircase avalanche photodetector (APD) as a solid-state analog of the photomultiplier tube. In this structure, electron multiplication occurs deterministically at steps in the conduction band profile, which function as the dynodes of a photomultiplier tube, leading to low excess multiplication noise. Unlike traditional APDs, the origin of staircase gain is band engineering rather than large applied electric fields. Unfortunately, the materials available at the time, principally AlxGa1-xAs/GaAs, did not offer sufficiently large conduction band offsets and energy separations between the direct and indirect valleys to realize the full potential of the staircase gain mechanism. Here, we report a true staircase APD operation using alloys of a rather underexplored material, AlxIn1-xAsySb1-y, lattice-matched to GaSb. Single step "staircase" devices exhibited a constant gain of ˜2×, over a broad range of applied bias, operating temperature, and excitation wavelengths/intensities, consistent with Monte Carlo calculations.

  9. Tenth Goddard Conference on Mass Storage Systems and Technologies in Cooperation with the Nineteenth IEEE Symposium on Mass Storage Systems

    NASA Technical Reports Server (NTRS)

    Kobler, Benjamin (Editor); Hariharan, P. C. (Editor)

    2002-01-01

    This document contains copies of those technical papers received in time for publication prior to the Tenth Goddard Conference on Mass Storage Systems and Technologies which is being held in cooperation with the Nineteenth IEEE Symposium on Mass Storage Systems at the University of Maryland University College Inn and Conference Center April 15-18, 2002. As one of an ongoing series, this Conference continues to provide a forum for discussion of issues relevant to the ingest, storage, and management of large volumes of data. The Conference encourages all interested organizations to discuss long-term mass storage requirements and experiences in fielding solutions. Emphasis is on current and future practical solutions addressing issues in data management, storage systems and media, data acquisition, long-term retention of data, and data distribution. This year's discussion topics include architecture, future of current technology, storage networking with emphasis on IP storage, performance, standards, site reports, and vendor solutions. Tutorials will be available on perpendicular magnetic recording, object based storage, storage virtualization and IP storage.

  10. Eighth Goddard Conference on Mass Storage Systems and Technologies in Cooperation with the Seventeenth IEEE Symposium on Mass Storage Systems

    NASA Technical Reports Server (NTRS)

    Kobler, Benjamin (Editor); Hariharan, P. C. (Editor)

    2000-01-01

    This document contains copies of those technical papers received in time for publication prior to the Eighth Goddard Conference on Mass Storage Systems and Technologies which is being held in cooperation with the Seventeenth IEEE Symposium on Mass Storage Systems at the University of Maryland University College Inn and Conference Center March 27-30, 2000. As one of an ongoing series, this Conference continues to provide a forum for discussion of issues relevant to the management of large volumes of data. The Conference encourages all interested organizations to discuss long term mass storage requirements and experiences in fielding solutions. Emphasis is on current and future practical solutions addressing issues in data management, storage systems and media, data acquisition, long term retention of data, and data distribution. This year's discussion topics include architecture, future of current technology, new technology with a special emphasis on holographic storage, performance, standards, site reports, vendor solutions. Tutorials will be available on stability of optical media, disk subsystem performance evaluation, I/O and storage tuning, functionality and performance evaluation of file systems for storage area networks.

  11. IEEE 802.15.4 ZigBee-Based Time-of-Arrival Estimation for Wireless Sensor Networks

    PubMed Central

    Cheon, Jeonghyeon; Hwang, Hyunsu; Kim, Dongsun; Jung, Yunho

    2016-01-01

    Precise time-of-arrival (TOA) estimation is one of the most important techniques in RF-based positioning systems that use wireless sensor networks (WSNs). Because the accuracy of TOA estimation is proportional to the RF signal bandwidth, using broad bandwidth is the most fundamental approach for achieving higher accuracy. Hence, ultra-wide-band (UWB) systems with a bandwidth of 500 MHz are commonly used. However, wireless systems with broad bandwidth suffer from the disadvantages of high complexity and high power consumption. Therefore, it is difficult to employ such systems in various WSN applications. In this paper, we present a precise time-of-arrival (TOA) estimation algorithm using an IEEE 802.15.4 ZigBee system with a narrow bandwidth of 2 MHz. In order to overcome the lack of bandwidth, the proposed algorithm estimates the fractional TOA within the sampling interval. Simulation results show that the proposed TOA estimation algorithm provides an accuracy of 0.5 m at a signal-to-noise ratio (SNR) of 8 dB and achieves an SNR gain of 5 dB as compared with the existing algorithm. In addition, experimental results indicate that the proposed algorithm provides accurate TOA estimation in a real indoor environment. PMID:26861331

  12. IEEE 802.15.4 ZigBee-Based Time-of-Arrival Estimation for Wireless Sensor Networks.

    PubMed

    Cheon, Jeonghyeon; Hwang, Hyunsu; Kim, Dongsun; Jung, Yunho

    2016-02-05

    Precise time-of-arrival (TOA) estimation is one of the most important techniques in RF-based positioning systems that use wireless sensor networks (WSNs). Because the accuracy of TOA estimation is proportional to the RF signal bandwidth, using broad bandwidth is the most fundamental approach for achieving higher accuracy. Hence, ultra-wide-band (UWB) systems with a bandwidth of 500 MHz are commonly used. However, wireless systems with broad bandwidth suffer from the disadvantages of high complexity and high power consumption. Therefore, it is difficult to employ such systems in various WSN applications. In this paper, we present a precise time-of-arrival (TOA) estimation algorithm using an IEEE 802.15.4 ZigBee system with a narrow bandwidth of 2 MHz. In order to overcome the lack of bandwidth, the proposed algorithm estimates the fractional TOA within the sampling interval. Simulation results show that the proposed TOA estimation algorithm provides an accuracy of 0.5 m at a signal-to-noise ratio (SNR) of 8 dB and achieves an SNR gain of 5 dB as compared with the existing algorithm. In addition, experimental results indicate that the proposed algorithm provides accurate TOA estimation in a real indoor environment.

  13. Trustworthy data collection from implantable medical devices via high-speed security implementation based on IEEE 1363.

    PubMed

    Hu, Fei; Hao, Qi; Lukowiak, Marcin; Sun, Qingquan; Wilhelm, Kyle; Radziszowski, Stanisław; Wu, Yao

    2010-11-01

    Implantable medical devices (IMDs) have played an important role in many medical fields. Any failure in IMDs operations could cause serious consequences and it is important to protect the IMDs access from unauthenticated access. This study investigates secure IMD data collection within a telehealthcare [mobile health (m-health)] network. We use medical sensors carried by patients to securely access IMD data and perform secure sensor-to-sensor communications between patients to relay the IMD data to a remote doctor's server. To meet the requirements on low computational complexity, we choose N-th degree truncated polynomial ring (NTRU)-based encryption/decryption to secure IMD-sensor and sensor-sensor communications. An extended matryoshkas model is developed to estimate direct/indirect trust relationship among sensors. An NTRU hardware implementation in very large integrated circuit hardware description language is studied based on industry Standard IEEE 1363 to increase the speed of key generation. The performance analysis results demonstrate the security robustness of the proposed IMD data access trust model.

  14. Guideline-driven telemonitoring and follow-up of cardiovascular implantable electronic devices using IEEE 11073, HL7 & IHE profiles.

    PubMed

    Yang, Maohua; Chronaki, Catherine E; Lüpkes, Christian; Thiel, Andreas; Plössnig, Manuela; Hinterbuchner, Lynne; Arbelo, Elena; Laleci, Gokce Banu; Kabak, Yildiray; Duarte, Fernandez; Guillén, Alejandra; Navarro, Xavier; Dogac, Asuman; Eichelberg, Marco; Hein, Andreas

    2011-01-01

    For patients with Cardiovascular Implantable Electronic Devices (CIEDs), telemonitoring promises improved quality of life and safety, since events recorded by the device or observed by the patient can alert a health professional. Taking into account the latest clinical guidelines when responding to such alerts, is a topic of active research addressed by the iCARDEA project. A key technical challenge is correlating telemonitoring CIED report data in a vendor-independent format with Electronic Health Record (EHR) data collected in the hospital and Personal Health Record (PHR) data entered by the patient, in guideline-driven care processes. The iCARDEA CIED exposure service component presented in this paper employs standards specifications from ISO/IEEE 11073 (Health Informatics, Point-of-care Medical Device Communication) and HL7v2.x in the context of Integrating the Healthcare Enterprise (IHE) profiles to deliver telemonitoring CIED report data from two different CIED vendors to the adaptive care planner that implements guideline-driven care plans. Experience gained with implementation and initial component testing is discussed, while challenges and expectations for future health information standards to effectively support EHR-integrated guide-line-driven telemonitoring services are highlighted.

  15. Performance analysis for IEEE 802.11 distributed coordination function in radio-over-fiber-based distributed antenna systems.

    PubMed

    Fan, Yuting; Li, Jianqiang; Xu, Kun; Chen, Hao; Lu, Xun; Dai, Yitang; Yin, Feifei; Ji, Yuefeng; Lin, Jintong

    2013-09-09

    In this paper, we analyze the performance of IEEE 802.11 distributed coordination function in simulcast radio-over-fiber-based distributed antenna systems (RoF-DASs) where multiple remote antenna units (RAUs) are connected to one wireless local-area network (WLAN) access point (AP) with different-length fiber links. We also present an analytical model to evaluate the throughput of the systems in the presence of both the inter-RAU hidden-node problem and fiber-length difference effect. In the model, the unequal delay induced by different fiber length is involved both in the backoff stage and in the calculation of Ts and Tc, which are the period of time when the channel is sensed busy due to a successful transmission or a collision. The throughput performances of WLAN-RoF-DAS in both basic access and request to send/clear to send (RTS/CTS) exchange modes are evaluated with the help of the derived model.

  16. Implementation of a wireless ECG acquisition SoC for IEEE 802.15.4 (ZigBee) applications.

    PubMed

    Wang, Liang-Hung; Chen, Tsung-Yen; Lin, Kuang-Hao; Fang, Qiang; Lee, Shuenn-Yuh

    2015-01-01

    This paper presents a wireless biosignal acquisition system-on-a-chip (WBSA-SoC) specialized for electrocardiogram (ECG) monitoring. The proposed system consists of three subsystems, namely, 1) the ECG acquisition node, 2) the protocol for standard IEEE 802.15.4 ZigBee system, and 3) the RF transmitter circuits. The ZigBee protocol is adopted for wireless communication to achieve high integration, applicability, and portability. A fully integrated CMOS RF front end containing a quadrature voltage-controlled oscillator and a 2.4-GHz low-IF (i.e., zero-IF) transmitter is employed to transmit ECG signals through wireless communication. The low-power WBSA-SoC is implemented by the TSMC 0.18-μm standard CMOS process. An ARM-based displayer with FPGA demodulation and an RF receiver with analog-to-digital mixed-mode circuits are constructed as verification platform to demonstrate the wireless ECG acquisition system. Measurement results on the human body show that the proposed SoC can effectively acquire ECG signals.

  17. Device interoperability and authentication for telemedical appliance based on the ISO/IEEE 11073 Personal Health Device (PHD) Standards.

    PubMed

    Caranguian, Luther Paul R; Pancho-Festin, Susan; Sison, Luis G

    2012-01-01

    In this study, we focused on the interoperability and authentication of medical devices in the context of telemedical systems. A recent standard called the ISO/IEEE 11073 Personal Health Device (X73-PHD) Standards addresses the device interoperability problem by defining common protocols for agent (medical device) and manager (appliance) interface. The X73-PHD standard however has not addressed security and authentication of medical devices which is important in establishing integrity of a telemedical system. We have designed and implemented a security policy within the X73-PHD standards. The policy will enable device authentication using Asymmetric-Key Cryptography and the RSA algorithm as the digital signature scheme. We used two approaches for performing the digital signatures: direct software implementation and use of embedded security modules (ESM). The two approaches were evaluated and compared in terms of execution time and memory requirement. For the standard 2048-bit RSA, ESM calculates digital signatures only 12% of the total time for the direct implementation. Moreover, analysis shows that ESM offers more security advantage such as secure storage of keys compared to using direct implementation. Interoperability with other systems was verified by testing the system with LNI Healthlink, a manager software that implements the X73-PHD standard. Lastly, security analysis was done and the system's response to common attacks on authentication systems was analyzed and several measures were implemented to protect the system against them.

  18. On the network convergence process in RPL over IEEE 802.15.4 multihop networks: improvement and trade-offs.

    PubMed

    Kermajani, Hamidreza; Gomez, Carles

    2014-07-07

    The IPv6 Routing Protocol for Low-power and Lossy Networks (RPL) has been recently developed by the Internet Engineering Task Force (IETF). Given its crucial role in enabling the Internet of Things, a significant amount of research effort has already been devoted to RPL. However, the RPL network convergence process has not yet been investigated in detail. In this paper we study the influence of the main RPL parameters and mechanisms on the network convergence process of this protocol in IEEE 802.15.4 multihop networks. We also propose and evaluate a mechanism that leverages an option available in RPL for accelerating the network convergence process. We carry out extensive simulations for a wide range of conditions, considering different network scenarios in terms of size and density. Results show that network convergence performance depends dramatically on the use and adequate configuration of key RPL parameters and mechanisms. The findings and contributions of this work provide a RPL configuration guideline for network convergence performance tuning, as well as a characterization of the related performance trade-offs.

  19. Telemonitoring systems interoperability challenge: an updated review of the applicability of ISO/IEEE 11073 standards for interoperability in telemonitoring.

    PubMed

    Galarraga, M; Serrano, L; Martinez, I; de Toledo, P; Reynolds, Melvin

    2007-01-01

    Advances in Information and Communication Technologies, ICT, are bringing new opportunities and use cases in the field of systems and Personal Health Devices used for the telemonitoring of citizens in Home or Mobile scenarios. At a time of such challenges, this review arises from the need to identify robust technical telemonitoring solutions that are both open and interoperable. These systems demand standardized solutions to be cost effective and to take advantage of standardized operation and interoperability. Thus, the fundamental challenge is to design plug-&-play devices that, either as individual elements or as components, can be incorporated in a simple way into different Telecare systems, perhaps configuring a personal user network. Moreover, there is an increasing market pressure from companies not traditionally involved in medical markets, asking for a standard for Personal Health Devices, which foresee a vast demand for telemonitoring, wellness, Ambient Assisted Living (AAL) and e-health applications. However, the newly emerging situations imply very strict requirements for the protocols involved in the communication. The ISO/IEEE 11073 family of standards is adapting and moving in order to face the challenge and might appear the best positioned international standards to reach this goal. This work presents an updated survey of these standards, trying to track the changes that are being fulfilled, and tries to serve as a starting-point for those who want to familiarize themselves with them.

  20. Biomedical learning experiences for middle school girls sponsored by the Kansas State University Student Chapter of the IEEE EMBS.

    PubMed

    Gruber, Lucinda; Griffith, Connor; Young, Ethan; Sullivan, Adriann; Schuler, Jeff; Arnold-Christian, Susan; Warren, Steve

    2009-01-01

    Learning experiences for middle school girls are an effective means to steer young women toward secondary engineering curricula that they might not have otherwise considered. Sponsorship of such experiences by a collegiate student group is worthwhile, as it gives the group common purpose and places college students in a position to mentor these young women. This paper addresses learning experiences in different areas of bio-medical engineering offered to middle school girls in November 2008 via a day-long workshop entitled "Engineering The Body." The Kansas State University (KSU) Student Chapter of the IEEE Engineering in Medicine and Biology Society (EMBS) worked with the KSU Women in Engineering and Science Program (WESP) to design and sponsor these experiences, which addressed the areas of joint mechanics, electrocardiograms, membrane transport, computer mouse design, and audio filters for cochlear implants. Fifty five middle-school girls participated in this event, affirming the notion that biomedical engineering appeals to young women and that early education and recruitment efforts have the potential to expand the biomedical engineering talent pool.

  1. On the Network Convergence Process in RPL over IEEE 802.15.4 Multihop Networks: Improvement and Trade-Offs

    PubMed Central

    Kermajani, Hamidreza; Gomez, Carles

    2014-01-01

    The IPv6 Routing Protocol for Low-power and Lossy Networks (RPL) has been recently developed by the Internet Engineering Task Force (IETF). Given its crucial role in enabling the Internet of Things, a significant amount of research effort has already been devoted to RPL. However, the RPL network convergence process has not yet been investigated in detail. In this paper we study the influence of the main RPL parameters and mechanisms on the network convergence process of this protocol in IEEE 802.15.4 multihop networks. We also propose and evaluate a mechanism that leverages an option available in RPL for accelerating the network convergence process. We carry out extensive simulations for a wide range of conditions, considering different network scenarios in terms of size and density. Results show that network convergence performance depends dramatically on the use and adequate configuration of key RPL parameters and mechanisms. The findings and contributions of this work provide a RPL configuration guideline for network convergence performance tuning, as well as a characterization of the related performance trade-offs. PMID:25004154

  2. Photolysis of hop-derived trans-iso-alpha-acids and trans-tetrahydroiso-alpha-acids: product identification in relation to the lightstruck flavour of beer.

    PubMed

    Heyerick, Arne; Zhao, Yining; Sandra, Pat; Huvaere, Kevin; Roelens, Frederik; De Keukeleire, Denis

    2003-03-01

    The photolysis of hop-derived trans-iso-alpha-acids (2a-c; naturally occurring bitter compounds present in beer) and of trans-tetrahydroiso-alpha-acids (5a-c; semi-synthetic advanced hop products) was investigated at 300 nm in methanol. The complex photoreaction mixtures were separated by high-performance liquid chromatography (HPLC) using diode array detection and the major photoreaction products were identified by HPLC-mass spectroscopy. The main part of the mixture consisted of compounds, which originated from recombination of radicals derived from Norrish Type I photocleavage of the acyloin moiety in both trans-iso-alpha-acids and trans-tetrahydroiso-alpha-acids. The results confirm the intermediacy of radicals that were previously identified by time-resolved electron paramagnetic resonance and they bear relevance to the formation of the lightstruck flavour that is generated when beer is exposed to light. Additionally, new photoproducts were found that are formed by photochemical reactions hitherto undiscovered in hop chemistry, including photoenolization of trans-isohumulone (2a) leading to trans-alloisohumulone (13a) and a retro oxa-di-pi-methane rearrangement in trans-isohumulone (2a) and trans-tetrahydroiso-alpha-acids to humulone (1a) and tetrahydro-alpha-acids (23a-b), respectively.

  3. 21 CFR 573.637 - Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... contain not less than 35 percent of other fatty acid esters composed of oleic acid, palmitic acid, stearic... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic acids). 573.637 Section 573.637 Food and Drugs FOOD...

  4. 76 FR 56873 - American Railroad Group Transportation Services, LLC d/b/a ARG Trans-Continuance in Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Surface Transportation Board American Railroad Group Transportation Services, LLC d/b/a ARG Trans... Railroad Group Transportation Services, LLC d/b/a ARG Trans (ARG Trans), a noncarrier, has filed a verified... currently owned by the Oregon International Port of Coos Bay. ARG Trans states that it currently owns...

  5. Capacitance-Voltage Study on the Effects of Low Energy Electron Radiation on Al(0.27)Ga(0.73)N/GaN High Electron Mobility Transistors

    DTIC Science & Technology

    2005-03-01

    grown and electron-irradiated n-GaN,” IEEE, 35-42 (2000). [27] D. C. Look, et al. “On the Nitrogen Vacancy in GaN,” Applied Physics Letters , Vol...Al0.27Ga0.73N/GaN HIGH ELECTRON MOBILITY TRANSISTORS THESIS Presented to the Faculty Department of Engineering Physics Graduate School of...of Tables Table Page 1. Physical properties of wide band gap semiconductors [10]...................................14 2. Competitive

  6. Reinvestigation of microwave spectrum, molecular structure, dipole moment, and theoretical calculation of s- trans ( E)- and s- trans ( Z)-acrylaldehyde oxime

    NASA Astrophysics Data System (ADS)

    Murakami, Arata; Hirose, Minako; Terashima, Mariko; Kuze, Nobuhiko; Sakaizumi, Takeshi; Ohashi, Osamu

    2004-03-01

    The spectroscopic constants of s- trans ( E)-acrylaldehyde oxime of normal, CH 2CHCHNOH, and deuterated, CH 2CHCHNOD, species were refined by adding a-type R-branch transitions observed in the frequency range of 34-40 GHz in the ground vibrational state. For s- trans ( Z) form, the spectroscopic constants of normal species were refined by refitting the reported frequencies with four b-type Q-branch transitions and those of deuterated species were determined by the least-squares fitting of the observed a-type R-branch transitions in the ground vibrational state. The spectroscopic constants of two isomers of normal species were also determined in the vibrationally excited states. The inertial defects (Δ I= Ic- Ia- Ib) of normal and deuterated species were determined to be -0.042(24) and -0.064(17) u Å 2 for s- trans ( E)-1 form, and -0.0536(8) and -0.063(11) u Å 2 for s- trans ( Z)-1 form, respectively. From the rs coordinates of the hydroxyl hydrogen atom determined for s- trans ( Z)-1 form, its OH bond was concluded to be at the trans position with respect to the CN double bond. The dipole moments of deuterated species of s- trans ( E)-1 form and those of normal and deuterated species of s- trans ( Z)-1 form were determined. The structural parameters of r(C 2C 3), ∠C 1C 2C 3, ∠C 2C 3N, and ∠C 3NO for s- trans ( E)-1 and s- trans ( Z)-1 forms were adjusted separately using to their rotational constants observed. It was found that the bond angle of ∠C 2C 3N in s- trans ( Z)-1 form are much wider than that in s- trans ( E)-1 form by about 10°. The difference between the observed and calculated (using MP2/6-311++G (d,p) level) rotational constants of s- trans ( Z)-1 form was larger than that of s- trans ( E)-1 form.

  7. Difference in effect of temperature on absorption and Raman spectra between all-trans-β-carotene and all-trans-retinol

    NASA Astrophysics Data System (ADS)

    Qu, Guan-Nan; Li, Shuo; Sun, Cheng-Lin; Liu, Tian-Yuan; Wu, Yong-Ling; Sun, Shang; Shan, Xiao-Ning; Men, Zhi-Wei; Chen, Wei; Li, Zuo-Wei; Gao, Shu-Qin

    2012-12-01

    Temperature dependencies (81 °C-18 °C) ofvisible absorption and Raman spectra of all-trans-β-carotene and all-trans-retinol extremely diluted in dimethyl sulfoxide are investigated in order to clarify temperature effects on different polyenes. Their absorption spectra are identified to be redshifted with temperature decreasing. Moreover, all-trans-β-carotene is more sensitive to temperature due to the presence of a longer length of conjugated system. The characteristic energy responsible for the conformational changes in all-trans-β-carotene is smaller than that in all-trans-retinol. Both of the Raman scattering cross sections increase with temperature decreasing. The results are explained with electron—phonon coupling theory and coherent weakly damped electron—lattice vibrations model.

  8. The inverse-trans-influence in tetravalent lanthanide and actinide bis(carbene) complexes

    NASA Astrophysics Data System (ADS)

    Gregson, Matthew; Lu, Erli; Mills, David P.; Tuna, Floriana; McInnes, Eric J. L.; Hennig, Christoph; Scheinost, Andreas C.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Kerridge, Andrew; Liddle, Stephen T.

    2017-02-01

    Across the periodic table the trans-influence operates, whereby tightly bonded ligands selectively lengthen mutually trans metal-ligand bonds. Conversely, in high oxidation state actinide complexes the inverse-trans-influence operates, where normally cis strongly donating ligands instead reside trans and actually reinforce each other. However, because the inverse-trans-influence is restricted to high-valent actinyls and a few uranium(V/VI) complexes, it has had limited scope in an area with few unifying rules. Here we report tetravalent cerium, uranium and thorium bis(carbene) complexes with trans C=M=C cores where experimental and theoretical data suggest the presence of an inverse-trans-influence. Studies of hypothetical praseodymium(IV) and terbium(IV) analogues suggest the inverse-trans-influence may extend to these ions but it also diminishes significantly as the 4f orbitals are populated. This work suggests that the inverse-trans-influence may occur beyond high oxidation state 5f metals and hence could encompass mid-range oxidation state actinides and lanthanides. Thus, the inverse-trans-influence might be a more general f-block principle.

  9. The inverse-trans-influence in tetravalent lanthanide and actinide bis(carbene) complexes

    PubMed Central

    Gregson, Matthew; Lu, Erli; Mills, David P.; Tuna, Floriana; McInnes, Eric J. L.; Hennig, Christoph; Scheinost, Andreas C.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Kerridge, Andrew; Liddle, Stephen T.

    2017-01-01

    Across the periodic table the trans-influence operates, whereby tightly bonded ligands selectively lengthen mutually trans metal–ligand bonds. Conversely, in high oxidation state actinide complexes the inverse-trans-influence operates, where normally cis strongly donating ligands instead reside trans and actually reinforce each other. However, because the inverse-trans-influence is restricted to high-valent actinyls and a few uranium(V/VI) complexes, it has had limited scope in an area with few unifying rules. Here we report tetravalent cerium, uranium and thorium bis(carbene) complexes with trans C=M=C cores where experimental and theoretical data suggest the presence of an inverse-trans-influence. Studies of hypothetical praseodymium(IV) and terbium(IV) analogues suggest the inverse-trans-influence may extend to these ions but it also diminishes significantly as the 4f orbitals are populated. This work suggests that the inverse-trans-influence may occur beyond high oxidation state 5f metals and hence could encompass mid-range oxidation state actinides and lanthanides. Thus, the inverse-trans-influence might be a more general f-block principle. PMID:28155857

  10. Performance Analysis of IEEE 802.11g Receivers With Erasure Decoding to Mitigate the Effects of Pulse-Noise Interference

    DTIC Science & Technology

    2006-12-01

    when the signal is transmitted over a frequency-selective, slowly fading Nakagami channel in a pulse-noise interference environment when errors-and...conditions when pulse-noise interference is present. 15. NUMBER OF PAGES 125 14. SUBJECT TERMS IEEE 802.11g WLAN Standard, Nakagami Fading...selective, slowly fading Nakagami channel in a pulse-noise interference environment when errors-and-erasures Viterbi decoding is used is examined. The

  11. Neural Networks for Signal Processing 5. Proceedings of the 1995 IEEE Workshop (5th) Held in Cambridge, MA on 31 Aug-2 Sep 95.

    DTIC Science & Technology

    1995-01-01

    S.N. Siihari Decision conbihiaton1 inmlti pJ classiflor isystenms. IEEE Tea as. on2 Potts on Awlolys is anl /la chine 1%.t’r r . 6 7:4 5,1994. 6’ F...local Cerebral Glucose Utilization: The- ory, Procedures and Normal Values in the Conscious and Anesthetized Albino Rat" Journal of Neurochemistry 28 897

  12. The Ships Below-Decks Electromagnetic Compatibility (EMC) Program. A compilation of Papers Presented at the 1987 IEEE International Symposium on EMC

    DTIC Science & Technology

    1987-09-30

    ballpoint pen eliminate EMT and/or EMP problems by shunting high style springs that were connected end-to-end around level currents into the systems’ ground...Ground Adapter," 1986 IEEE International 3. Develop a military performance specification for Symposium On EMC, September 1986. the solid cable shield...the BRASS GRAPHITE composite when given a set if specific zomponent STAINLESS STEEL RHODIUM material parameters. As a result of the effort, an COPPER

  13. FPGA Implementation of Reed-Solomon Decoder for IEEE 802.16 WiMAX Systems using Simulink-Sysgen Design Environment

    SciTech Connect

    Bobrek, Miljko; Albright, Austin P

    2012-01-01

    This paper presents FPGA implementation of the Reed-Solomon decoder for use in IEEE 802.16 WiMAX systems. The decoder is based on RS(255,239) code, and is additionally shortened and punctured according to the WiMAX specifications. Simulink model based on Sysgen library of Xilinx blocks was used for simulation and hardware implementation. At the end, simulation results and hardware implementation performances are presented.

  14. Report of the IEEE ICES/COST 281 Thermal Physiology Workshop Held in Paris, France on September 22-24, 2004

    DTIC Science & Technology

    2006-02-27

    MHz) in human volunteers. Bioelectromagnetics . 2003 Oct;24(7):502-9 Adair ER, Mylacraine KS, Allen SJ.Thermophysiological consequences of whole body...resonant RF exposure (100 MHz) in human volunteers. Bioelectromagnetics . 2003 Oct;24(7):489-501 Adair ER, Mylacraine KS, Cobb BL. Human exposure to...2450 MHz CW energy at levels outside the IEEE C95.1 standard does not increase core temperature. Bioelectromagnetics . 2001 Sep;22(6):429-39 Adair

  15. Improved Projections of 21st Century Trans-Arctic Shipping

    NASA Astrophysics Data System (ADS)

    Melia, N.; Haines, K.; Hawkins, E.

    2015-12-01

    Climate models unanimously project a decline in the extent and thickness of Arctic sea ice as the climate warms, but at differing rates. Projecting the timing of an ice-free Arctic is a topic that has received considerable scientific and public attention. An ice-free Arctic opens up the potential for shorter global trade routes through the Arctic Ocean and there has already been a sharp increase in the number of transits along Russia's Northern Sea Route with escorts from nuclear powered icebreakers.Here we present results on the future of trans-Arctic shipping using bias corrected sea ice thickness projections, utilising the CMIP5 multi-model ensemble and considering multiple emission scenarios. We find that for 'Open Water' vessels (normal ocean going vessels that possess no specific ice strengthening), unaided trans-Arctic shipping is likely to become feasible in the next couple of decades. We find that the North West Passage will open approximately a decade later than the Northern Sea Route. Initially however, both routes exhibit marked inter-annual variability in accessibility which we quantify. The hypothesised trans-polar sea route through international waters via the North Pole will start to become navigable by 2050. Towards the latter period of the 21st century, normal ocean going vessels will be able to transit their choice of any of these routes for at least six months of any given year under the RCP 8.5 high future emissions scenario and four months for the lower RCP 4.5 emissions scenario. These findings suggest that further increases in global temperature could transform the Arctic into a global transport hub.

  16. Trans-scleral tactile tonometry: an instrumented approach.

    PubMed

    Polyvás, Péter P; Peyman, Gholam; Enikov, Eniko T

    2013-07-01

    This article describes a feasibility study of a novel trans-scleral tonometer based on the use of an instrumented form of digital palpation tonometry. Similar to manual digital palpation tonometery, trans-scleral tonometer utilizes two force probes offset by a fixed distance. Force indentation data from these probes have been shown to correlate with the intraocular pressure (IOP) of the eye. Enucleated porcine eyes were used to experimentally validate the approach. The observed hysteresis in the force data was analyzed using an analytical model that accounts for the outflow of the aqueous humor. The predictions of the model indicate that the primary reason behind the observed hysteresis is stress relaxation (accommodation) in the visco-elastic corneo-scleral shell. Experimental data from eye distention and indentation tests were then used to infer the conditions under which the novel tonometer would be expected to have an accuracy of ±1 mmHg. Analysis of the data shows that indentation rates should be kept below 0.5 mm/s for a pressure range of 10-35 mmHg. Two commonly used pressure control protocols were tested in an effort to ensure accurate IOP values during the palpation tests. Due to the large increase of IOP during digital palpation, the trans-scleral (intra-vitreous) pressurization was found to be inadequate, leading to clogging of the line by the displaced vitreous. No such problems were identified when the eye was pressurized through the cornea and into the anterior chamber. Force data from multiple palpation experiments are used to generate calibration curves for a two-probe conceptual tonometer. The calibration showed that a 10 mN of force variation corresponds to 1 mmHg of IOP change. A possible implementation using a contoured facial mask is also presented.

  17. What Is ALS?

    MedlinePlus

    ... Javits, actor David Niven, “Sesame Street” creator Jon Stone, boxing champion Ezzard Charles, NBA Hall of Fame ... Help for People with ALS and Caregivers Read stories from families living with ALS Forms of ALS ...

  18. A Security Solution for IEEE 802.11's Ad-hoc Mode:Password-Authentication and Group Diffie-Hellman Key Exchange

    SciTech Connect

    Emmanuel, Bresson; Olivier, Chevassut; David, Pointcheval

    2005-10-01

    The IEEE 802 standards ease the deployment of networkinginfrastructures and enable employers to accesscorporate networks whiletraveling. These standards provide two modes of communication calledinfrastructure and ad-hoc modes. A security solution for the IEEE802.11's infrastructure mode took several years to reach maturity andfirmware are still been upgraded, yet a solution for the ad-hoc modeneeds to be specified. The present paper is a first attempt in thisdirection. It leverages the latest developments in the area ofpassword-based authentication and (group) Diffie-Hellman key exchange todevelop a provably-secure key-exchange protocol for IEEE 802.11's ad-hocmode. The protocol allows users to securely join and leave the wirelessgroup at time, accommodates either a single-shared password orpairwise-shared passwords among the group members, or at least with acentral server; achieves security against dictionary attacks in theideal-hash model (i.e. random-oracles). This is, to the best of ourknowledge, the first such protocol to appear in the cryptographicliterature.

  19. Beyond either/or: Reading trans* lesbian identities.

    PubMed

    Gailey, Nerissa; Brown, A D

    2016-01-01

    Previous research has explored the affiliation and distancing strategies employed in published memoirs of gender transition. In this article, we are particularly interested in elucidating the ways in which individuals construct identities and characterize their sexualities, and how sociohistorical constraints might influence what is expressed with respect to this in personal narratives of transition. Using the memoirs of Lili Elbe (Hoyer, 1933) and Joy Ladin (2013) as conceptual brackets, this article investigates the complex relationship between the development and articulation of trans* identities and lesbian sexualities within the context of published memoirs of gender transition.

  20. Large-eddy simulation of trans- and supercritical injection

    NASA Astrophysics Data System (ADS)

    Müller, H.; Niedermeier, C. A.; Jarczyk, M.; Pfitzner, M.; Hickel, S.; Adams, N. A.

    2016-07-01

    In a joint effort to develop a robust numerical tool for the simulation of injection, mixing, and combustion in liquid rocket engines at high pressure, a real-gas thermodynamics model has been implemented into two computational fluid dynamics (CFD) codes, the density-based INCA and a pressure-based version of OpenFOAM. As a part of the validation process, both codes have been used to perform large-eddy simulations (LES) of trans- and supercritical nitrogen injection. Despite the different code architecture and the different subgrid scale turbulence modeling strategy, both codes yield similar results. The agreement with the available experimental data is good.

  1. TransFind—predicting transcriptional regulators for gene sets

    PubMed Central

    Kiełbasa, Szymon M.; Klein, Holger; Roider, Helge G.; Vingron, Martin; Blüthgen, Nils

    2010-01-01

    The analysis of putative transcription factor binding sites in promoter regions of coregulated genes allows to infer the transcription factors that underlie observed changes in gene expression. While such analyses constitute a central component of the in-silico characterization of transcriptional regulatory networks, there is still a lack of simple-to-use web servers able to combine state-of-the-art prediction methods with phylogenetic analysis and appropriate multiple testing corrected statistics, which returns the results within a short time. Having these aims in mind we developed TransFind, which is freely available at http://transfind.sys-bio.net/. PMID:20511592

  2. Protein sorting at the trans-Golgi network.

    PubMed

    Guo, Yusong; Sirkis, Daniel W; Schekman, Randy

    2014-01-01

    The trans-Golgi network (TGN) is an important cargo sorting station within the cell where newly synthesized proteins are packaged into distinct transport carriers that are targeted to various destinations. To maintain the fidelity of protein transport, elaborate protein sorting machinery is employed to mediate sorting of specific cargo proteins into distinct transport carriers. Protein sorting requires assembly of the cytosolic sorting machinery onto the TGN membrane and capture of cargo proteins. We review the cytosolic and transmembrane sorting machinery that function at the TGN and describe molecular interactions and regulatory mechanisms that enable accurate protein sorting. In addition, we highlight the importance of TGN sorting in physiology and disease.

  3. La región trans-neptuniana

    NASA Astrophysics Data System (ADS)

    Gil-Hutton, R.

    2015-08-01

    Our knowledge on the dynamics and physics of the objects that populate the region beyond Neptune's orbit has increased significantly over the last 20 years beginning with the discovery of (15760), the first trans-neptunian object discovered after (134340) Pluto and its satellite Charon. During this period it was possible to understand much of the dynamics of this region and find interesting physical characteristics of these objects. This report summarizes our current understanding of this population paying special attention to the description of some physical properties of these objects.

  4. Integrated Analysis of Market Transformation Scenarios with HyTrans

    SciTech Connect

    Greene, David L; Leiby, Paul Newsome; Bowman, David Charles

    2007-06-01

    This report presents alternative visions of the transition of light-duty vehicle transportation in the United States from petroleum to hydrogen power. It is a supporting document to the U.S. Department of Energy's Summary Report, "Analysis of the Transition to a Hydrogen Economy and the Potential Hydrogen Infrastructure Requirements" (U.S. DOE, 2007). Three alternative early transition scenarios were analyzed using a market simulation model called HyTrans. The HyTrans model simultaneously represents the behavior of fuel suppliers, vehicle manufacturers and consumers, explicitly recognizing the importance of fuel availability and the diversity of vehicle choices to consumers, and dependence of fuel supply on the existence of market demand. Competitive market outcomes are simulated by means of non-linear optimization of social surplus through the year 2050. The three scenarios specify different rates and geographical distributions of market penetration for hydrogen fuel cell vehicles from 2012 through 2025. Scenario 1 leads to 2 million vehicles on U.S. roads by 2025, while Scenarios 2 and 3 result in 5 million and 10 million FCVs in use by 2025, respectively. The HyTrans model "costs out" the transition scenarios and alternative policies for achieving them. It then tests whether the scenarios, together with the achievement of the DOE's technology goals for fuel cell vehicles and hydrogen infrastructure technologies could lead to a sustainable transition to hydrogen powered transportation. Given the achievement of DOE's ambitious technology goals, all three scenarios appear to lead to a sustainable transition to hydrogen. In the absence of early transition deployment effort, no transition is likely to begin before 2045. The cumulative costs of the transition scenarios to the government range from $8 billion to $45 billion, depending on the scenario, the policies adopted and the degree of cost-sharing with industry. In the absence of carbon constraining policies, the

  5. Trans-Planckian enhancements of the primordial non-Gaussianities

    SciTech Connect

    Collins, Hael; Holman, R.

    2009-08-15

    This article examines how breaking a Lorentz-invariant description of nature at tiny space-time intervals would affect the non-Gaussian character of the pattern of primordial perturbations left by inflation. We specifically study a set of irrelevant operators that preserve the spatial symmetries of the usual inflationary background. The non-Gaussian component in the primordial fluctuations can be much larger than the usual, small, inflationary prediction and can thus lead to much stronger constraints on the role of 'trans-Planckian' physics in inflation than those from the measurements of the primordial power spectrum.

  6. A Guided Tour of the Trans-Proteomic Pipeline

    PubMed Central

    Deutsch, Eric W.; Mendoza, Luis; Shteynberg, David; Farrah, Terry; Lam, Henry; Tasman, Natalie; Sun, Zhi; Nilsson, Erik; Pratt, Brian; Prazen, Bryan; Eng, Jimmy K.; Martin, Daniel B.; Nesvizhskii, Alexey; Aebersold, Ruedi

    2010-01-01

    The Trans-Proteomic Pipeline (TPP) is a suite of software tools for the analysis of tandem mass spectrometry datasets. The tools encompass most of the steps in a proteomic data analysis workflow in a single, integrated software system. Specifically, the TPP supports all steps from spectrometer output file conversion to protein-level statistical validation, including quantification by stable isotope ratios. We describe here the full workflow of the TPP and the tools therein, along with an example on a sample dataset, demonstrating that the set up and use of the tools is straightforward and well supported and does not require specialized informatics resources or knowledge. PMID:20101611

  7. Replacements for Trans Fats—Will There Be an Oil Shortage?

    PubMed Central

    Klonoff, David C.

    2007-01-01

    Manufacturers use the process of hydrogenation to create trans fats in order to increase the shelf life of baked and fried foods. Ingestion of trans fats is associated with an increased risk of cardiovascular disease. A groundswell of public sentiment is causing regulatory bodies to ban the use of trans fats in foods. Alternatives to trans fats are needed now in order to preserve the freshness and provide an appealing texture of many packaged foods. As trans fats become phased out, there are eight types of approaches currently being developed to substitute for these fats as ingredients for baked and fried foods: (1) modified hydrogenation, (2) genetically modified seeds, (3) interesterification, (4) fractionation and blending, (5) butter and animal fat, (6) natural saturated oils, (7) natural unsaturated oils, and (8) fat substitutes. These alternatives to trans fats will require close scrutiny to ascertain whether they will also turn out to be linked with cardiovascular disease. PMID:19885099

  8. trans-Dichloridobis[dicyclo­hex­yl(2,4,6-trimethyl­phen­yl)phosphane-κP]palladium(II)

    PubMed Central

    Buthelezi, Isaac; Chiririwa, Haleden; Ogutu, Hezron; Meijboom, Reinout

    2012-01-01

    The title compound, [PdCl2(C21H33P)2], forms a monomeric complex with a trans-square-planar coordination geometry about the PdII atom which lies on an inversion centre. The Pd—P bond lengths are 2.3760 (13) Å, while the Pd—Cl bond lengths are 2.3172 (14) Å. The observed structure was found to be closely related to that of trans-dichloridobis[dicyclo­hex­yl(phen­yl)phosphane-κP]palladium(II), [PdCl2{P(C6H11)2(C6H5)}2] [Burgoyne et al. (2012 ▶). Acta Cryst. E68, m404]. PMID:23284323

  9. Performance Analysis of Power Saving Mechanism Employing Both Sleep Mode and Idle Mode in IEEE 802.16e

    NASA Astrophysics Data System (ADS)

    Hwang, Eunju; Lee, Yong Hyun; Kim, Kyung Jae; Son, Jung Je; Choi, Bong Dae

    The IEEE 802.16e standard specifies the sleep mode and the idle mode of a mobile station (MS) for power saving. In this paper, to reduce the energy consumption of the MS, we employ the sleep mode while the MS is on-session, and the idle mode while it is off-session. Under the assumption that the time duration from the end of a session to the arrival of a new downlink session request follows an exponential distribution of the mean 1/ν and that arrivals of messages during an on-session follow a Poisson process with rate λ, we analyze the awake mode period and the sleep mode period by using the busy period analysis of the M/G/1 queue, and then we derive the total mean length of an on-session which consists of a geometric number of awake mode periods and sleep mode periods. Since the sum of an on-session and an off-session constitutes a cycle, we can express the average power consumption in terms of the mean lengths of an awake mode period, a sleep mode period and an idle mode period. The average power consumption indicates how much the MS can save energy by employing the sleep mode and the idle mode. We also derive the Laplace Stieltjes transform (and the mean) of the queueing delay of messages to examine a tradeoff between the power consumption and the delay of messages. Analytical results, which are shown to be well-matched by simulations, address that our employment of the sleep mode and the idle mode provides a considerable reduction in the energy consumption of the MS.

  10. Analysis of ISO/IEEE 11073 built-in security and its potential IHE-based extensibility.

    PubMed

    Rubio, Óscar J; Trigo, Jesús D; Alesanco, Álvaro; Serrano, Luis; García, José

    2016-04-01

    The ISO/IEEE 11073 standard for Personal Health Devices (X73PHD) aims to ensure interoperability between Personal Health Devices and aggregators-e.g. health appliances, routers-in ambulatory setups. The Integrating the Healthcare Enterprise (IHE) initiative promotes the coordinated use of different standards in healthcare systems (e.g. Personal/Electronic Health Records, alert managers, Clinical Decision Support Systems) by defining profiles intended for medical use cases. X73PHD provides a robust syntactic model and a comprehensive terminology, but it places limited emphasis on security and on interoperability with IHE-compliant systems and frameworks. However, the implementation of eHealth/mHealth applications in environments such as health and fitness monitoring, independent living and disease management (i.e. the X73PHD domains) increasingly requires features such as secure connections to mobile aggregators-e.g. smartphones, tablets-, the sharing of devices among different users with privacy, and interoperability with certain IHE-compliant healthcare systems. This work proposes a comprehensive IHE-based X73PHD extension consisting of additive layers adapted to different eHealth/mHealth applications, after having analyzed the features of X73PHD (especially its built-in security), IHE profiles related with these applications and other research works. Both the new features proposed for each layer and the procedures to support them have been carefully chosen to minimize the impact on X73PHD, on its architecture (in terms of delays and overhead) and on its framework. Such implications are thoroughly analyzed in this paper. As a result, an extended model of X73PHD is proposed, preserving its essential features while extending them with added value.

  11. The stability of retinol, alpha-tocopherol, trans-lycopene, and trans-beta-carotene in liquid-frozen and lyophilized serum.

    PubMed

    Brown Thomas, J; Duewer, D L; Kline, M C; Sharpless, K E

    1998-08-10

    The concentrations of retinol, alpha-tocopherol, and trans-beta-carotene in lyophilized serum stored at -25 degrees C and -80 degrees C have been monitored for 10 years. There was no evidence of degradation of any of these compounds over the 10-year period. Retinol, alpha-tocopherol, and trans-beta-carotene were less stable at -25 degrees C in liquid-frozen serum than they were in lyophilized serum. At -80 degrees C, trans-beta-carotene levels were stable for up to 3 years of storage in liquid-frozen serum. Both retinol and alpha-tocopherol appeared stable in liquid-frozen serum for at least 5 years at -80 degrees C. The effect of repeated freeze/thaw cycles on retinol, alpha-tocopherol, trans-lycopene, and trans-beta-carotene in liquid-frozen and reconstituted lyophilized serum both stored at -20 degrees C was also studied. Retinol, alpha-tocopherol, trans-lycopene, and trans-beta-carotene in reconstituted lyophilized serum stored at -20 degrees C were stable for at least 3 days with minimal (< 5) freeze/thaw cycles.

  12. Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation

    SciTech Connect

    Sanga, Madhu; Younis, Islam R.; Tirumalai, Padma S.; Bland, Tina M.; Banaszewska, Monica; Konat, Gregory W.; Tracy, Timothy S.; Gannett, Peter M.; Callery, Patrick S. . E-mail: pcallery@hsc.wvu.edu

    2006-03-01

    Pyrolytic products of smoked methamphetamine hydrochloride are well established. Among the various degradation products formed, trans-phenylpropene (trans-{beta}-methylstyrene) is structurally similar to styrene analogues known to be bioactivated by CYP enzymes. In human liver microsomes, trans-phenylpropene was converted to the epoxide trans-phenylpropylene oxide (trans-2-methyl-3-phenyloxirane) and cinnamyl alcohol. Incubation of trans-phenylpropene with microsomes in the presence of enzyme-specific P450 enzyme inhibitors indicated the involvement of CYP2E1, CYP1A2, and CYP3A4 enzymes. Both (R,R)-phenylpropylene oxide and (S,S)-phenylpropylene oxide were formed in human liver microsomal preparations. Enantiomers of trans-phenylpropylene oxide were stereoselectively and regioselectively conjugated in a Phase II drug metabolism reaction catalyzed by human liver cytosolic enzymes consisting of conjugation with glutathione. The structure of the phenylpropylene oxide-glutathione adduct is consistent with nucleophilic ring-opening by attack at the benzylic carbon. Exposure of cultured C6 glial cells to (S,S)-phenylpropylene oxide produced a cytotoxic response in a concentration-dependent manner based on cell degeneration and death.

  13. Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation.

    PubMed

    Sanga, Madhu; Younis, Islam R; Tirumalai, Padma S; Bland, Tina M; Banaszewska, Monica; Konat, Gregory W; Tracy, Timothy S; Gannett, Peter M; Callery, Patrick S

    2006-03-01

    Pyrolytic products of smoked methamphetamine hydrochloride are well established. Among the various degradation products formed, trans-phenylpropene (trans-beta-methylstyrene) is structurally similar to styrene analogues known to be bioactivated by CYP enzymes. In human liver microsomes, trans-phenylpropene was converted to the epoxide trans-phenylpropylene oxide (trans-2-methyl-3-phenyloxirane) and cinnamyl alcohol. Incubation of trans-phenylpropene with microsomes in the presence of enzyme-specific P450 enzyme inhibitors indicated the involvement of CYP2E1, CYP1A2, and CYP3A4 enzymes. Both (R,R)-phenylpropylene oxide and (S,S)-phenylpropylene oxide were formed in human liver microsomal preparations. Enantiomers of trans-phenylpropylene oxide were stereoselectively and regioselectively conjugated in a Phase II drug metabolism reaction catalyzed by human liver cytosolic enzymes consisting of conjugation with glutathione. The structure of the phenylpropylene oxide-glutathione adduct is consistent with nucleophilic ring-opening by attack at the benzylic carbon. Exposure of cultured C6 glial cells to (S,S)-phenylpropylene oxide produced a cytotoxic response in a concentration-dependent manner based on cell degeneration and death.

  14. "The intersections of trans women and lesbian identities, communities, and movements": An introduction.

    PubMed

    Beemyn, Genny; Eliason, Mickey

    2016-01-01

    This introduction to the special issue on "The Intersections of Trans Women and Lesbian Identities, Communities, and Movements" considers the interconnectedness of "trans" and "lesbian" as identities and as concepts. Our approach challenges a reading of the two communities as largely separate and adversarial. In reviewing the articles included in this issue, we highlight places of intersection between the two identities, including the experiences of the individuals who live at the intersectional point: trans lesbians.

  15. It All Starts with a Sandwich: Identification of Sialidases with Trans-Glycosylation Activity

    PubMed Central

    Nordvang, Rune T.; Nyffenegger, Christian; Holck, Jesper; Jers, Carsten; Sundekilde, Ulrik K.; Meyer, Anne S.; Mikkelsen, Jørn D.

    2016-01-01

    Sialidases (3.2.1.18) may exhibit trans-sialidase activity to catalyze sialylation of lactose if the active site topology is congruent with that of the Trypanosoma cruzi trans-sialidase (EC 2.4.1.-). The present work was undertaken to test the hypothesis that a particular aromatic sandwich structure of two amino acids proximal to the active site of the T. cruzi trans-sialidase infers trans-sialidase activity. On this basis, four enzymes with putative trans-sialidase activity were identified through an iterative alignment from 2909 native sialidases available in GenBank, which were cloned and expressed in Escherichia coli. Of these, one enzyme, SialH, derived from Haemophilus parasuis had an aromatic sandwich structure on the protein surface facing the end of the catalytic site (Phe168; Trp366), and was indeed found to exhibit trans-sialidase activity. SialH catalyzed production of the human milk oligosaccharide 3’-sialyllactose as well as the novel trans-sialylation product 3-sialyllactose using casein glycomacropeptide as sialyl donor and lactose as acceptor. The findings corroborated that Tyr119 and Trp312 in the T. cruzi trans-sialidase are part of an aromatic sandwich structure that confers trans-sialylation activity for lactose sialylation. The in silico identification of trans-glycosidase activity by rational active site topology alignment thus proved to be a quick tool for selecting putative trans-sialidases amongst a large group of glycosyl hydrolases. The approach moreover provided data that help understand structure-function relations of trans-sialidases. PMID:27367145

  16. Biodegradation kinetics of trans-4-methyl-1-cyclohexane carboxylic acid.

    PubMed

    Paslawski, Janice C; Headley, John V; Hill, Gordon A; Nemati, Mehdi

    2009-02-01

    Naphthenic acids are a complex mixture of organic compounds which naturally occur in crude oil. Low molecular weight components of the naphthenic acids are known to be toxic in aquatic environments and there is a need to better understand the factors controlling the kinetics of their biodegradation. In this study, a relatively low molecular weight naphthenic acid compound (trans-isomer of 4-methyl-1-cyclohexane carboxylic acid) and a microbial culture developed in our laboratory were used to study the biodegradation of this naphthenic acid and to evaluate the kinetics of the process in batch cultures. The initial concentration of trans-4-methyl-1-cyclohexane carboxylic acid (50-750 mg l(-1)) did not affect the maximum specific growth rate of the bacteria at 23 degrees C (0.52 day(-1)) to the maximum biodegradable concentration (750 mg l(-1)). The maximum yield observed at this temperature and at a neutral pH was 0.21 mg of biomass per milligram of substrate. Batch experiments indicated that biodegradation can be achieved at low temperatures; however, the biodegradation rate at room temperature (23 degrees C) and neutral pH was 5 times faster than that observed at 4 degrees C. Biodegradation at various pH conditions indicated a maximum specific growth rate of 1.69 day(-1) and yield (0.41 mg mg(-1)) at a pH of 10.

  17. Spliced leader RNA trans-splicing discovered in copepods

    PubMed Central

    Yang, Feifei; Xu, Donghui; Zhuang, Yunyun; Yi, Xiaoyan; Huang, Yousong; Chen, Hongju; Lin, Senjie; Campbell, David A.; Sturm, Nancy R.; Liu, Guangxing; Zhang, Huan

    2015-01-01

    Copepods are one of the most abundant metazoans in the marine ecosystem, constituting a critical link in aquatic food webs and contributing significantly to the global carbon budget, yet molecular mechanisms of their gene expression are not well understood. Here we report the detection of spliced leader (SL) trans-splicing in calanoid copepods. We have examined nine species of wild-caught copepods from Jiaozhou Bay, China that represent the major families of the calanoids. All these species contained a common 46-nt SL (CopepodSL). We further determined the size of CopepodSL precursor RNA (slRNA; 108-158 nt) through genomic analysis and 3′-RACE technique, which was confirmed by RNA blot analysis. Structure modeling showed that the copepod slRNA folded into typical slRNA secondary structures. Using a CopepodSL-based primer set, we selectively enriched and sequenced copepod full-length cDNAs, which led to the characterization of copepod transcripts and the cataloging of the complete set of 79 eukaryotic cytoplasmic ribosomal proteins (cRPs) for a single copepod species. We uncovered the SL trans-splicing in copepod natural populations, and demonstrated that CopepodSL was a sensitive and specific tool for copepod transcriptomic studies at both the individual and population levels and that it would be useful for metatranscriptomic analysis of copepods. PMID:26621068

  18. Randomized Subspace Learning for Proline Cis-Trans Isomerization Prediction.

    PubMed

    Al-Jarrah, Omar Y; Yoo, Paul D; Taha, Kamal; Muhaidat, Sami; Shami, Abdallah; Zaki, Nazar

    2015-01-01

    Proline residues are common source of kinetic complications during folding. The X-Pro peptide bond is the only peptide bond for which the stability of the cis and trans conformations is comparable. The cis-trans isomerization (CTI) of X-Pro peptide bonds is a widely recognized rate-limiting factor, which can not only induces additional slow phases in protein folding but also modifies the millisecond and sub-millisecond dynamics of the protein. An accurate computational prediction of proline CTI is of great importance for the understanding of protein folding, splicing, cell signaling, and transmembrane active transport in both the human body and animals. In our earlier work, we successfully developed a biophysically motivated proline CTI predictor utilizing a novel tree-based consensus model with a powerful metalearning technique and achieved 86.58 percent Q2 accuracy and 0.74 Mcc, which is a better result than the results (70-73 percent Q2 accuracies) reported in the literature on the well-referenced benchmark dataset. In this paper, we describe experiments with novel randomized subspace learning and bootstrap seeding techniques as an extension to our earlier work, the consensus models as well as entropy-based learning methods, to obtain better accuracy through a precise and robust learning scheme for proline CTI prediction.

  19. Cis and trans interactions between atlastin molecules during membrane fusion

    PubMed Central

    Liu, Tina Y.; Bian, Xin; Romano, Fabian B.; Shemesh, Tom; Rapoport, Tom A.; Hu, Junjie

    2015-01-01

    Atlastin (ATL), a membrane-anchored GTPase that mediates homotypic fusion of endoplasmic reticulum (ER) membranes, is required for formation of the tubular network of the peripheral ER. How exactly ATL mediates membrane fusion is only poorly understood. Here we show that fusion is preceded by the transient tethering of ATL-containing vesicles caused by the dimerization of ATL molecules in opposing membranes. Tethering requires GTP hydrolysis, not just GTP binding, because the two ATL molecules are pulled together most strongly in the transition state of GTP hydrolysis. Most tethering events are futile, so that multiple rounds of GTP hydrolysis are required for successful fusion. Supported lipid bilayer experiments show that ATL molecules sitting on the same (cis) membrane can also undergo nucleotide-dependent dimerization. These results suggest that GTP hydrolysis is required to dissociate cis dimers, generating a pool of ATL monomers that can dimerize with molecules on a different (trans) membrane. In addition, tethering and fusion require the cooperation of multiple ATL molecules in each membrane. We propose a comprehensive model for ATL-mediated fusion that takes into account futile tethering and competition between cis and trans interactions. PMID:25825753

  20. Future Projections of Trans-Arctic Shipping Potential and Variability

    NASA Astrophysics Data System (ADS)

    Stephenson, S. R.; Smith, L. C.

    2014-12-01

    As the Arctic Ocean transitions towards a seasonally ice-free state, efforts to predict new connections between the Arctic and the global economy are underway. In particular, record lows in September sea ice extent from 2007-2013 have recast Arctic shipping routes as emerging international seaways for export of resources and as potential alternative pathways for global trade. While ensemble-averaged output from sea ice models suggest significant increases in vessel accessibility in September by midcentury (Smith & Stephenson, 2013), the seasonal length and variability of trans-Arctic shipping is not well understood. In addition, differences in ice extent due to inter-model variability reveal significant uncertainties in the magnitude and location of future vessel access. Here we present several scenarios of 21st-century trans-Arctic shipping as driven by sea ice output from CMIP5 models. Optimal vessel transits from North America and Europe to the Bering Strait are estimated for two periods representing present-day (2006-2015) and midcentury (2040-2059) conditions under two forcing scenarios (RCP 4.5/8.5), assuming Polar Class 6 (PC6) and open-water vessels (OW) with medium and no ice-breaking capability, respectively. Results illustrate a range of potential futures for shipping in the Arctic owing to differences in model choice, vessel capability, and climate forcing. Inter-model differences reveal the importance of model choice in devising projections for strategic planning by governments, environmental agencies, and the global maritime industry.

  1. MetaTrans: an open-source pipeline for metatranscriptomics.

    PubMed

    Martinez, Xavier; Pozuelo, Marta; Pascal, Victoria; Campos, David; Gut, Ivo; Gut, Marta; Azpiroz, Fernando; Guarner, Francisco; Manichanh, Chaysavanh

    2016-05-23

    To date, meta-omic approaches use high-throughput sequencing technologies, which produce a huge amount of data, thus challenging modern computers. Here we present MetaTrans, an efficient open-source pipeline to analyze the structure and functions of active microbial communities using the power of multi-threading computers. The pipeline is designed to perform two types of RNA-Seq analyses: taxonomic and gene expression. It performs quality-control assessment, rRNA removal, maps reads against functional databases and also handles differential gene expression analysis. Its efficacy was validated by analyzing data from synthetic mock communities, data from a previous study and data generated from twelve human fecal samples. Compared to an existing web application server, MetaTrans shows more efficiency in terms of runtime (around 2 hours per million of transcripts) and presents adapted tools to compare gene expression levels. It has been tested with a human gut microbiome database but also proposes an option to use a general database in order to analyze other ecosystems. For the installation and use of the pipeline, we provide a detailed guide at the following website (www.metatrans.org).

  2. MetaTrans: an open-source pipeline for metatranscriptomics

    PubMed Central

    Martinez, Xavier; Pozuelo, Marta; Pascal, Victoria; Campos, David; Gut, Ivo; Gut, Marta; Azpiroz, Fernando; Guarner, Francisco; Manichanh, Chaysavanh

    2016-01-01

    To date, meta-omic approaches use high-throughput sequencing technologies, which produce a huge amount of data, thus challenging modern computers. Here we present MetaTrans, an efficient open-source pipeline to analyze the structure and functions of active microbial communities using the power of multi-threading computers. The pipeline is designed to perform two types of RNA-Seq analyses: taxonomic and gene expression. It performs quality-control assessment, rRNA removal, maps reads against functional databases and also handles differential gene expression analysis. Its efficacy was validated by analyzing data from synthetic mock communities, data from a previous study and data generated from twelve human fecal samples. Compared to an existing web application server, MetaTrans shows more efficiency in terms of runtime (around 2 hours per million of transcripts) and presents adapted tools to compare gene expression levels. It has been tested with a human gut microbiome database but also proposes an option to use a general database in order to analyze other ecosystems. For the installation and use of the pipeline, we provide a detailed guide at the following website (www.metatrans.org). PMID:27211518

  3. Conservation of trans-acting networks during mammalian regulatory evolution

    PubMed Central

    Stergachis, Andrew B.; Neph, Shane; Sandstrom, Richard; Haugen, Eric; Reynolds, Alex P.; Zhang, Miaohua; Byron, Rachel; Canfield, Theresa; Stelhing-Sun, Sandra; Lee, Kristen; Thurman, Robert E.; Vong, Shinny; Bates, Daniel; Neri, Fidencio; Diegel, Morgan; Giste, Erika; Dunn, Douglas; Hansen, R. Scott; Johnson, Audra K.; Sabo, Peter J.; Wilken, Matthew S.; Reh, Thomas A.; Treuting, Piper M.; Kaul, Rajinder; Groudine, Mark; Bender, M.A.; Borenstein, Elhanan; Stamatoyannopoulos, John A.

    2014-01-01

    The fundamental body plan and major physiological axes have been highly conserved during mammalian evolution, despite constraint of only a fraction of the human genome sequence. To quantify cis- vs. trans-regulatory contributions to mammalian regulatory evolution, we performed genomic DNase I footprinting of the mouse genome across 25 cell and tissue types, collectively defining >8.6 million TF occupancy sites at nucleotide resolution. Here we show that mouse TF footprints encode a regulatory lexicon of >600 motifs that is >95% similar with that recognized in vivo by human TFs. However, only ~20% of mouse TF footprints have human orthologues. Despite substantial turnover of the cis-regulatory landscape around each TF gene, nearly half of all pairwise regulatory interactions connecting mouse TF genes have been maintained in orthologous human cell types through evolutionary innovation of TF recognition sequences. Strikingly, the higher-level organization of mouse TF-to-TF connections into cellular network architectures is nearly identical with human. Our results suggest that evolutionary selection on mammalian gene regulation is targeted chiefly at the level of trans-regulatory circuitry. PMID:25409825

  4. Spliced leader RNA trans-splicing discovered in copepods

    NASA Astrophysics Data System (ADS)

    Yang, Feifei; Xu, Donghui; Zhuang, Yunyun; Yi, Xiaoyan; Huang, Yousong; Chen, Hongju; Lin, Senjie; Campbell, David A.; Sturm, Nancy R.; Liu, Guangxing; Zhang, Huan

    2015-12-01

    Copepods are one of the most abundant metazoans in the marine ecosystem, constituting a critical link in aquatic food webs and contributing significantly to the global carbon budget, yet molecular mechanisms of their gene expression are not well understood. Here we report the detection of spliced leader (SL) trans-splicing in calanoid copepods. We have examined nine species of wild-caught copepods from Jiaozhou Bay, China that represent the major families of the calanoids. All these species contained a common 46-nt SL (CopepodSL). We further determined the size of CopepodSL precursor RNA (slRNA; 108-158 nt) through genomic analysis and 3‧-RACE technique, which was confirmed by RNA blot analysis. Structure modeling showed that the copepod slRNA folded into typical slRNA secondary structures. Using a CopepodSL-based primer set, we selectively enriched and sequenced copepod full-length cDNAs, which led to the characterization of copepod transcripts and the cataloging of the complete set of 79 eukaryotic cytoplasmic ribosomal proteins (cRPs) for a single copepod species. We uncovered the SL trans-splicing in copepod natural populations, and demonstrated that CopepodSL was a sensitive and specific tool for copepod transcriptomic studies at both the individual and population levels and that it would be useful for metatranscriptomic analysis of copepods.

  5. Suicide risk factors among trans feminine individuals in Lebanon.

    PubMed

    Kaplan, Rachel L; Nehme, Simon; Aunon, Frances; de Vries, David; Wagner, Glenn

    Transgender women are disproportionately affected by high rates of depression and suicide attempts. It is therefore important to identify factors that influence suicidal risk, particularly in the Middle East where little research has examined the mental health of transgender women. We examined risk factors associated with suicide attempts among 54 trans feminine individuals in Beirut, Lebanon. Data were collected using interviewer-administered questionnaires and analyzed using bivariate statistics. Twenty-five (46%) participants reported having ever attempted suicide. Among them, only one participant received some kind of counseling in response to the attempted suicide. Low general social support, low social integration, and low support from peers were significantly associated with a history of attempted suicide, as were being more open about transgender identity in public and any hormone use (past or current). These findings suggest that progression in gender transition can have unintended consequences related to mental health and suicide risk, while social support systems can mitigate the impact of mental health problems. Some of these findings mirror other contexts around the globe and can inform mental health services for trans feminine individuals in Lebanon, the greater Middle East region, and other international settings.

  6. Trans-Americas leads the way into municipal textile recycling

    SciTech Connect

    Ridgley, H.

    1998-08-01

    Most textile waste in the US still goes to the landfill--an estimated 6.6 million tons each year. But thanks to the efforts of textile recycles--such as Trans-Americas Textile Recycling CO. (Brooklyn, NY)--another 1.25 million tons gets salvaged for reuse overseas or as a feedstock for the wiping and fiber industries, according to the Council for Textile Recycling. In an era where global population levels are increasing the demand for textile waste from the Western world and municipalities are struggling to reach their waste diversion goals, boosting textile recovery rates makes sense. And it`s a waste that can be easily incorporated into existing municipal curbside or drop-off recycling programs. Since 1942, when the company first opened its doors in Brooklyn, NY, it purchased textile discards from charities. While those discards still make up the majority of Trans-Americas` supply, in the last two years, the company also began purchasing post-consumer material from municipalities. Textiles are definitely going to be an increasingly important part of recycling, as states look to meet their mandates.

  7. A Study of the IEEE 802.16 MAC Layer and its Utility in Augmenting the ADNS Architecture to Provide Adaptable Intra-Strike Group High-Speed Packet Switched Data, Imagery, and Voice Communications

    DTIC Science & Technology

    2005-09-01

    MAC) of the IEEE 802.16 Wireless standard and its utility in augmenting the IP (Internet Protocol) router based Automated Digital Network System (ADNS...evaluates the Medium Access Control Layer (MAC) of the IEEE 802.16 wireless standard and its utility in augmenting the IP (Internet Protocol) router based ...ATM Asynchronous Transfer Mode BE Best Effort BR Bandwidth Request BS Base Station BW Bandwidth C2 Command and Control CDMA Code

  8. HIV Prevalence, Sexual Partners, Sexual Behavior and HIV Acquisition Risk Among Trans Men, San Francisco, 2014.

    PubMed

    McFarland, Willi; Wilson, Erin C; Raymond, Henry F

    2017-02-24

    We surveyed 122 trans men using a hybrid sampling method that included randomly selected physical and online venues and peer referral to measure HIV prevalence and risk behaviors. HIV prevalence was 0% (one-sided 97.5% confidence interval 0-3.3%). Of 366 partnerships described, 44.8% were with cisgender women, 23.8% with cisgender men, 20.8% with trans men, and 10.7% with trans women. Condomless receptive anal and front hole/vaginal sex averaged one to three episodes per six months. HIV prevalence in trans men is likely closer to heterosexual cisgender men and women in San Francisco than trans women or MSM. Prevention prioritizing trans women and MSM, coupled with individualized and relevant sexual health education for trans men with partners from these populations, may best address the HIV prevention needs of trans men. Systematic collection of transgender status in Census and health data is needed to understand other health disparities among trans men.

  9. Boycunts and bonus holes: trans men's bodies, neoliberalism, and the sexual productivity of genitals.

    PubMed

    Edelman, Elijah Adiv; Zimman, Lal

    2014-01-01

    Recent theorizations of trans embodiment have brought attention to the ways neoliberalism limits the productivity of nonnormatively gendered bodies. This article deals with the discursive framing of embodiment and sexual desirability among trans men and other transmasculine persons negotiating Internet-mediated homoerotic spaces. Micro-level analysis of discourse structure and macro-level analysis of socio-political context together show how trans men navigate homonormative sexual economies by linguistically recuperating their bodies' sexually productivity. Instead of undermining claims of embodied masculinity and homoerotic value, potential sites of exclusion-i.e., trans genitals-become sites of flexible accumulation that enhance rather than detract from their bearers' desirability.

  10. Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation.

    PubMed

    Ryu, Sangwoo; Seol, Geun Hee; Park, Hyeon; Choi, In-Young

    2014-10-01

    Trans-anethole has been studied on pharmacological properties such as anti-inflammation, anti-oxidative stress, antifungal and anticancer. However, to date, the anti-ischemic effects of trans-anethole have not been assessed. Therefore, we investigated the neuroprotection of trans-anethole against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cortical neuronal cell injury, an in vitro model of ischemia. The abilities of trans-anethole to block excitotoxicity, oxidative stress and mitochondrial dysfunction were evaluated in OGD/R-induced neurons. Trans-anethole significantly ameliorated OGD/R-induced neuronal cell injury by attenuating the intracellular calcium overload via the activation of NMDA receptors. Trans-anethole also inhibited OGD/R-induced reactive oxygen species overproduction, which may be derived from the scavenging activity in peroxyl radicals, assessed in an oxygen radical absorbance capacity assay. Furthermore, trans-anethole was shown to attenuate the depolarization of mitochondrial transmembrane. These results indicated that the neuroprotective effect of trans-anethole on OGD/R-induced neuronal injury might be due to its ability to inhibit excitotoxicity, oxidative stress and mitochondrial dysfunction. Considering these multiple pathways causing ischemic neuronal damage, the multi-functional effect of trans-anethole suggested that it may be effective in treating ischemic stroke.

  11. Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation).

    PubMed

    Zhu, Zheng; Spicer, Elizabeth G; Gavini, Chaitanya K; Goudjo-Ako, Ashley J; Novak, Colleen M; Shi, Haifei

    2014-02-10

    Brown adipose tissue (BAT) burns calories to produce heat, and is thus relevant to energy balance. Interscapular BAT (IBAT) of donor mice was transplanted into recipient mice (transBATation). To test whether transBATation counteracts high-fat diet (HFD)-induced obesity, some sham-operated and recipient mice were fed a HFD (HFD-sham, HFD-trans) while others remained on a standard chow (chow-sham, chow-trans). HFD-trans mice had lower body weight and fat and greater energy expenditure, but similar caloric intake compared with HFD-sham mice. We hypothesized that HFD-trans mice had elevated sympathetic activity compared with HFD-sham mice, contributing to increased energy expenditure and fuel mobilization. This was supported by findings that HFD-trans mice had greater energy expenditure during a norepinephrine challenge test and higher core temperatures after cold exposure than did HFD-sham mice, implicating enhanced whole-body metabolic response and elevated sympathetic activity. Additionally, transBATation selectively increased sympathetic drive to some, but not all, white adipose tissue depots and skeletal muscles, as well as the endogenous IBAT, heart, and liver. Collectively, transBATation confers resistance to HFD-induced obesity via increase in whole-body sympathetic activity, and differential activation of sympathetic drive to some of the tissues involved in energy expenditure and fuel mobilization.

  12. Abu al-Layth al-Libi

    DTIC Science & Technology

    2015-02-01

    Introduction In the tradition of post-9/11 senior Arab militant figures operating in Khurasan (the Afghanistan-Pakistan region), there is little doubt as to...the standing of Libyan jihadi commander Abu al-Layth al-Libi. If Usama bin Ladin and Ayman al-Zawahiri came to be the most prominent Arab -Afghan...Libi, a longtime leader of the Libyan Islamic Fighting Group (LIFG), who rapidly established himself as the champion of the Arab -Afghan milieu after

  13. IEEE Sensors 2004 Conference

    DTIC Science & Technology

    2004-10-27

    simulate real world conditions it is open to the environment where laboratory air is pulled through a large PVC pipe in which the CWA simulants (DCP...sensors based on nanoparticle W03 thick films They used commercial W03 nanopowder from Aldrich, this was mixed with InCl3 or BiCI3 and screen printed onto...through a large PVC pipe in which the CWA simulants each stage. In the first stage we wish to eliminate any con- (DCP (I,5-dichloropentane) - mustard

  14. IEEE TRANSACTIONS ON CYBERNETICS

    SciTech Connect

    Craig R. RIeger; David H. Scheidt; William D. Smart

    2014-11-01

    MODERN societies depend on complex and critical infrastructures for energy, transportation, sustenance, medical care, emergency response, communications security. As computers, automation, and information technology (IT) have advanced, these technologies have been exploited to enhance the efficiency of operating the processes that make up these infrastructures

  15. Extreme trans-Neptunian objects and the Kozai mechanism: signalling the presence of trans-Plutonian planets

    NASA Astrophysics Data System (ADS)

    de la Fuente Marcos, C.; de la Fuente Marcos, R.

    2014-09-01

    The existence of an outer planet beyond Pluto has been a matter of debate for decades and the recent discovery of 2012 VP113 has just revived the interest for this controversial topic. This Sedna-like object has the most distant perihelion of any known minor planet and the value of its argument of perihelion is close to 0°. This property appears to be shared by almost all known asteroids with semimajor axis greater than 150 au and perihelion greater than 30 au (the extreme trans-Neptunian objects or ETNOs), and this fact has been interpreted as evidence for the existence of a super-Earth at 250 au. In this scenario, a population of stable asteroids may be shepherded by a distant, undiscovered planet larger than the Earth that keeps the value of their argument of perihelion librating around 0° as a result of the Kozai mechanism. Here, we study the visibility of these ETNOs and confirm that the observed excess of objects reaching perihelion near the ascending node cannot be explained in terms of any observational biases. This excess must be a true feature of this population and its possible origin is explored in the framework of the Kozai effect. The analysis of several possible scenarios strongly suggest that at least two trans-Plutonian planets must exist.

  16. DNA damage in lymphocytes of benzene exposed workers correlates with trans,trans-muconic acids and breath benzene levels.

    PubMed

    Sul, Donggeun; Lee, Eunil; Lee, Mi-Young; Oh, Eunha; Im, Hosub; Lee, Joohyun; Jung, Woon-Won; Won, Namhee; Kang, Hyung-Sik; Kim, Eun-Mi; Kang, Seong-Kyu

    2005-04-04

    Benzene causes many kinds of blood disorders in workers employed in many different environments. These diseases include myelodisplastic syndrome and acute and chronic myelocytic leukemia. In the present study, five occupational work places, including six industrial process types, namely, printing, shoe-making, methylene di-aniline (MDA), nitrobenzene, carbomer, and benzene production were selected, and the levels of breath benzene, and trans,trans-muconic acids (t,t-MA) and phenol in urine were evaluated, as well as hematological changes and lymphocyte DNA damage. The concentration of benzene in breath was less than 3 ppm in the workplaces, and benzene exposure was found to be higher in work places where benzene is used, than in those where benzene is produced. At low levels of benzene exposure, urinary t,t-MA correlated strongly with benzene in air. Highest Olive tail moments were found in workers producing carbomer. Levels of breathzone benzene were found to be strongly correlated with Olive tail moment values in the lymphocytes of workers, but not with hematological data in the six workplaces types. In conclusion, the highest benzene exposures found occurred in workers at a company, which utilized benzene in the production of carbomer. In terms of low levels of exposure to benzene, urinary t,t-MA and DNA damage exhibited a strong correlation with breath benzene, but not with hematological data. We conclude that breath benzene, t,t-MA and lymphocytic DNA damage are satisfactory biomonitoring markers with respect to benzene exposure in the workplace.

  17. A novel random effect model for GWAS meta-analysis and its application to trans-ethnic meta-analysis

    PubMed Central

    Shi, Jingchunzi; Lee, Seunggeun

    2016-01-01

    Summary Meta-analysis of trans-ethnic genome-wide association studies (GWAS) has proven to be a practical and profitable approach for identifying loci that contribute to the risk of complex diseases. However, the expected genetic effect heterogeneity cannot easily be accommodated through existing fixed-effects and random-effects methods. In response, we propose a novel random effect model for trans-ethnic meta-analysis with flexible modeling of the expected genetic effect heterogeneity across diverse populations. Specifically, we adopt a modified random effect model from the kernel regression framework, in which genetic effect coefficients are random variables whose correlation structure reflects the genetic distances across ancestry groups. In addition, we use the adaptive variance component test to achieve robust power regardless of the degree of genetic effect heterogeneity. Simulation studies show that our proposed method has well-calibrated type I error rates at very stringent significance levels and can improve power over the traditional meta-analysis methods. We re-analyzed the published type 2 diabetes GWAS meta-analysis (Consortium et al., 2014) and successfully identified one additional SNP that clearly exhibits genetic effect heterogeneity across different ancestry groups. Furthermore, our proposed method provides scalable computing time for genome-wide datasets, in which an analysis of one million SNPs would require less than 3 hours. PMID:26916671

  18. Uptake of conjugated linolenic acids and conversion to cis-9, trans-11-or trans-9, trans-11-conjugated linoleic acids in Caco-2 cells.

    PubMed

    Schneider, Anne-Catherine; Mignolet, Eric; Schneider, Yves-Jacques; Larondelle, Yvan

    2013-01-14

    Dietary oils containing large amounts of conjugated linolenic acids (CLnA) may be regarded as a source of conjugated linoleic acids (CLA), which have been suspected to bear health-promoting properties. Indeed, CLnA can be converted into CLA in mammals. The objective of the present study was to investigate the uptake of CLnA and their metabolism into CLA in Caco-2 cells, as a validated in vitro model of the intestinal barrier. Caco-2 cells were incubated for 24 h in the presence of either α-eleostearic, β-eleostearic, catalpic or punicic acid. We first observed that Caco-2 cells take these CLnA up at different rates and then convert them but with varying efficiency depending on the structure of the Δ13 double bond. Finally, the distribution of CLnA between neutral lipids (NL) and phospholipids appeared to be linked to their number of trans double bonds: the higher the number, the higher the accumulation in the NL fraction.

  19. 2,3-trans-3,4-trans-3,4-Dihydroxy-L-proline: An amino acid in toxic peptides of Amanita virosa mushrooms

    PubMed Central

    Buku, A.; Faulstich, H.; Wieland, T.; Dabrowski, J.

    1980-01-01

    Among the four possible stereoisomers of 3,4-dihydroxy-L-proline,2,3-trans-3,4-trans-3,4-dihydroxy-L-proline (IV) had not been found in nature previously. It has now been detected as a component of virotoxins, toxic peptides of Amanita virosa mushrooms. Because periodate failed to effect an oxidative glycol splitting reaction, the two hydroxyl groups in positions 3 and 4 were expected to be in a trans configuration. Furthermore, the formation of a 4-lactone on treatment with acids pointed to the carboxyl group and the hydroxyl group at position 4 being in a cis configuration. These results are in agreement with structure IV only. Final proof for structure IV was given by NMR spectroscopy and direct comparison with the 2,3-cis-3,4-trans-3,4-dihydroxy-L-proline isomer. PMID:16592813

  20. Coarse-grained simulations of cis- and trans-polybutadiene: A bottom-up approach

    NASA Astrophysics Data System (ADS)

    Lemarchand, Claire A.; Couty, Marc; Rousseau, Bernard

    2017-02-01

    We apply the dissipative particle dynamics strategy proposed by Hijón et al. [Faraday Discuss. 144, 301-322 (2010)] and based on an exact derivation of the generalized Langevin equation to cis- and trans-1,4-polybutadiene. We prove that it is able to reproduce not only the structural but also the dynamical properties of these polymers without any fitting parameter. A systematic study of the effect of the level of coarse-graining is done on cis-1,4-polybutadiene. We show that as the level of coarse-graining increases, the dynamical properties are better and better reproduced while the structural properties deviate more and more from those calculated in molecular dynamics (MD) simulations. We suggest two reasons for this behavior: the Markovian approximation is better satisfied as the level of coarse-graining increases, while the pair-wise approximation neglects important contributions due to the relative orientation of the beads at large levels of coarse-graining. Finally, we highlight a possible limit of the Markovian approximation: the fact that in constrained simulations, in which the centers-of-mass of the beads are kept constant, the bead rotational dynamics become extremely slow.

  1. Coarse-grained simulations of cis- and trans-polybutadiene: A bottom-up approach.

    PubMed

    Lemarchand, Claire A; Couty, Marc; Rousseau, Bernard

    2017-02-21

    We apply the dissipative particle dynamics strategy proposed by Hijón et al. [Faraday Discuss. 144, 301-322 (2010)] and based on an exact derivation of the generalized Langevin equation to cis- and trans-1,4-polybutadiene. We prove that it is able to reproduce not only the structural but also the dynamical properties of these polymers without any fitting parameter. A systematic study of the effect of the level of coarse-graining is done on cis-1,4-polybutadiene. We show that as the level of coarse-graining increases, the dynamical properties are better and better reproduced while the structural properties deviate more and more from those calculated in molecular dynamics (MD) simulations. We suggest two reasons for this behavior: the Markovian approximation is better satisfied as the level of coarse-graining increases, while the pair-wise approximation neglects important contributions due to the relative orientation of the beads at large levels of coarse-graining. Finally, we highlight a possible limit of the Markovian approximation: the fact that in constrained simulations, in which the centers-of-mass of the beads are kept constant, the bead rotational dynamics become extremely slow.

  2. Science Signaling Podcast for 20 December 2016: Trans-inhibition by Fc receptors.

    PubMed

    Daëron, Marc; VanHook, Annalisa M

    2016-12-20

    This Podcast features an interview with Marc Daëron, author of a Research Article that appears in the 20 December 2016 issue of Science Signaling, about a mechanism by which an Fc receptor can inhibit signaling by other receptors without aggregating with those other receptors. Engagement of Fc receptors on basophils and mast cells can either activate these cells, which promotes autoimmune and allergic inflammation, or prevent these cells from being activated. Whether these cells are activated depends upon which Fc receptors are present in clusters, because some Fc receptors can inhibit signaling by other Fc receptors that are present in the same signalosome, a phenomenon known as cis-inhibition. Malbec et al. identified a mechanism whereby inhibitory Fc receptors limit signaling by activating Fc receptors without being present in the same signalosome. This mechanism of trans-inhibition also allowed inhibitory Fc receptors to limit signaling by growth factor receptors in mast cells and oncogene-induced proliferation in mastocytoma cells.Listen to Podcast.

  3. The photophysics of all-trans polyenes from ttbP5, a nonphotolabile pentaene.

    PubMed

    Catalán, Javier; Pérez, Pilar; Hopf, Henning; Klein, Dagmar

    2008-07-07

    The all-trans pentaene, 3,12-di(tert-butyl)-2,2,13,13-tetramethyl-3,5,7,9,11-tetradecapentaene (ttbP5) fluoresces in two different regions of the visible spectrum. It produces an extremely weak emission in the gas phase that can also be detected in the condensed phase; such an emission exhibits a negligible Stokes shift with respect to the 1Ag-->1Bu absorption transition and can in principle be assigned to the 1Bu-->1Ag emission of the compound. ttbP5 also exhibits a second fluorescence emission at approximately 520 nm in both the gas phase and the condensed phase. The emission in the condensed phase increases in strength and structure, with no change in spectral position, as the solvent viscosity increases by effect of the solution temperature being lowered. The spectral behavior of this pentaene (ttbP5) is different enough from that reported [J. Catalan et al., J. Chem. Phys. 128, 104504 (2008)] for its tetraene counterpart (ttbP4) to warrant a separate analysis in order to facilitate a better understanding of the way the photophysics of these polyenes changes as their chain is lengthened.

  4. The photophysics of all-trans polyenes from ttbP5, a nonphotolabile pentaene

    NASA Astrophysics Data System (ADS)

    Catalán, Javier; Pérez, Pilar; Hopf, Henning; Klein, Dagmar

    2008-07-01

    The all-trans pentaene, 3,12-di(tert-butyl)-2,2,13,13-tetramethyl-3,5,7,9,11-tetradecapentaene (ttbP5) fluoresces in two different regions of the visible spectrum. It produces an extremely weak emission in the gas phase that can also be detected in the condensed phase; such an emission exhibits a negligible Stokes shift with respect to the 1Ag→1Bu absorption transition and can in principle be assigned to the 1Bu→1Ag emission of the compound. ttbP5 also exhibits a second fluorescence emission at approximately 520nm in both the gas phase and the condensed phase. The emission in the condensed phase increases in strength and structure, with no change in spectral position, as the solvent viscosity increases by effect of the solution temperature being lowered. The spectral behavior of this pentaene (ttbP5) is different enough from that reported [J. Catalán et al., J. Chem. Phys. 128, 104504 (2008)] for its tetraene counterpart (ttbP4) to warrant a separate analysis in order to facilitate a better understanding of the way the photophysics of these polyenes changes as their chain is lengthened.

  5. Capacitive Trans-Impedance Amplifier Circuit with Charge Injection Compensation

    NASA Technical Reports Server (NTRS)

    Milkov, Mihail M. (Inventor); Gulbransen, David J. (Inventor)

    2016-01-01

    A capacitive trans-impedance amplifier circuit with charge injection compensation is provided. A feedback capacitor is connected between an inverting input port and an output port of an amplifier. A MOS reset switch has source and drain terminals connected between the inverting input and output ports of the amplifier, and a gate terminal controlled by a reset signal. The reset switch is open or inactive during an integration phase, and closed or active to electrically connect the inverting input port and output port of the amplifier during a reset phase. One or more compensation capacitors are provided that are not implemented as gate oxide or MOS capacitors. Each compensation capacitor has a first port connected to a compensation signal that is a static signal or a toggling compensation signal that toggles between two compensation voltage values, and a second port connected to the inverting input port of the amplifier.

  6. An Eocene flora from trans-Pecos Texas

    USGS Publications Warehouse

    Berry, Edward Wilber

    1920-01-01

    During the fall of 1916 I received a small collection of fossil plants which had been obtained during a geologic reconnaissance of the trans-Pecos region of Texas, by Charles Lawrence Baker. A preliminary report was sent to Mr. Baker in November of that year and was quoted in his discussion of the geology of that region. I have since made a careful study of the collection, and although it contains only a few species the occurrence of fossil plans in this region is worthy of more definite and detailed record, especially as these plants enabled me to assign a definite age to the beginning of the igneous activity of the region and to establish correlations between the floras of the Mississippi embayment and the Rocky Mountain Region.

  7. Arch development with trans-force lingual appliances.

    PubMed

    Clark, William J

    2005-01-01

    Trans-Force lingual appliances are designed to correct arch form in patients with contracted dental arches. Interceptive treatment with this new series of pre-activated lingual appliances offers new possibilities for arch development, in combination with fixed appliances. Palatal and lingual appliances insert in horizontal lingual sheaths in molar bands. No activation is required after the appliance is fitted, and this principle is extended to a series of appliances for sagittal and transverse arch development. Both sagittal and transverse appliances have additional components to achieve 3-way expansion where this is indicated. The invisible lingual appliances may be used in correction of all classes of malocclusion at any stage of development, from mixed dentition through permanent dentition, and this approach has wide indications in adult treatment.

  8. A Survey of Mission Opportunities to Trans-Neptunian Objects

    NASA Astrophysics Data System (ADS)

    McGranaghan, R.; Sagan, B.; Dove, G.; Tullos, A.; Lyne, J. E.; Emery, J. P.

    Preliminary designs for high thrust, flyby missions to five large trans-Neptunian Objects are discussed, with an emphasis on Quaoar, but also including Sedna, Makemake, Haumea, and Eris. The primary focus of this study was the design of the interplanetary trajectory for Earth departure dates between 2014 and 2050. The best trajectories identified use only a Jupiter gravity assist, require a total mission delta-V as low as 7.15 km/s and have arrival V values at the target comparable to those of the New Horizons mission to Pluto. Transit times range from 13.57 years for missions to Quaoar to 24.48 years to reach Sedna and Eris. Jupiter periapse radius is a critical factor for these missions, with satisfactory trajectories requiring values ranging from 3.5 to 25 planetary radii.

  9. Stay Tuned! An Automatic RSS Feeds Trans-coder

    NASA Astrophysics Data System (ADS)

    Salamin, Patrick; Wetzel, Alexandre; Thalmann, Daniel; Vexo, Frédéric

    News aggregators are widely used to read RSS feeds but they require the user to be in front of a screen. While moving, people usually do not have any display, or very small ones. Moreover, they need to perform actions to get access to the news: download a tool, choose to generate audio files from the news, and send them to e.g. an MP3 player. We propose in this paper a system that automatically detects when the user leaves the computer room and directly sends the trans-coded news onto the user Smartphone. All the aggregated news are then transmitted to the user who can listen to them without any action. We present in this paper such a system and the very promising results we obtained after testing it.

  10. Myofascial pain from pectoralis major following trans-axillary surgery.

    PubMed

    Cummings, Mike

    2003-09-01

    This is the first reported description, to the author's knowledge, of myofascial pain occurring at a surgical drain site. The patient consulted a medical acupuncturist after suffering five months of continuous chest and arm pain associated with 'tingling' in the forearm and hand. She had undergone trans-axillary resection of the first left rib following a left axillary vein thrombosis 18 months previously. Her symptoms had been principally attributed to nerve traction at surgery or nerve root entrapment from scar tissue. However, the drain passed through the free border of pectoralis major, and the myofascial trigger point that appeared to develop as a result of the muscle trauma, or the pain at that site, presented as a chronic and complex post-surgical pain problem. The pain and tingling resolved completely after two sessions of dry needling at a single myofascial trigger point in the free border of the left pectoralis major muscle.

  11. Bilateral trans-humeral arm transplantation: result at 2 years.

    PubMed

    Cavadas, P C; Ibáñez, J; Thione, A; Alfaro, L

    2011-05-01

    Unilateral and bilateral hand transplantations have been performed worldwide with good mid-term functional results. An above-elbow bilateral transplantation was performed in a 29-year-old male patient from a fully HLA-mismatched donor. Alemtuzumab induction and steroid-free maintenance immunosuppression with tacrolimus and mycophenolate was used. Due to acute rejection, steroids were introduced at 6 months. Three acute rejection episodes occurred, one treated with alemtuzumab. New-onset diabetes after transplant, dyslipemia and worsening of previous high blood pressure required treatment. At 26 months post-transplantation, the patient has excellent elbow active movement, active flexion and extension of the thumb and fingers, useful sensation and a gainful job. Based on the functional results of the case reported, bilateral trans-humeral transplantation could be a viable treatment for selected bilateral above-elbow amputees.

  12. Viral trans-dominant manipulation of algal sphingolipids.

    PubMed

    Michaelson, Louise V; Dunn, Teresa M; Napier, Johnathan A

    2010-12-01

    Emiliania huxleyi is the host for the coccolithovirus (EhV), which is responsible for the demise of large oceanic blooms formed by this alga. The EhV-86 virus genome sequence has identified several genes apparently involved in sphingolipid metabolism. Recently, an unusual glucosylceramide from E. huxleyi infected with EhV-86 was isolated, implicating sphingolipids in the lysis of this alga. However, the EhV-86-encoded genes contain only a subset of the activities required to generate the novel sphingolipid, implying that its synthesis is the result of coordinated interactions between algal- and viral-encoded biosynthetic enzymes. Here, we discuss the likely role for EhV-86 open reading frames (ORFs) in the synthesis of novel sphingolipids and also consider the concept of the trans-dominant manipulation of lipid metabolism.

  13. Trans-Asian pipe line; A prefeasibility study

    SciTech Connect

    Banerjee, N. )

    1991-11-01

    Building a 2,100 mi Trans-Asian natural gas system to transport 36 Bm{sup 3}/y Iranian natural gas from the Sarkhum field to Calcutta is under consideration by Iran, Pakistan and India. As proposed in this paper, the pipe line will pass through desert, alluvial plains, mountainous, rocky and marshy terrain, dense rain forests and agricultural lands, and will cross numerous rail, road, and major river crossings. Depending on the gas volume distributed along the route, the trunkline diameter is estimated at 66-in., 54-in. and 48-in. about 24 compressor stations will be located along the line approximately 80 mi apart. A SCADA communication and control system will operate on UHF radio link between microwave towers or through a satellite network. Microwave towers are estimated at 492-ft with some 6,562-ft towers required in mountainous regions.

  14. Microelements in solonchaks of the western Trans-Baikal region

    NASA Astrophysics Data System (ADS)

    Sosorova, S. B.; Merkusheva, M. G.; Boloneva, L. N.; Baldanova, A. L.; Ubugunov, L. L.

    2016-04-01

    Distribution patterns of microelements (Mn, Zn, Ni, Cu, Cr, Co, Pb, and Cd) in solonchaks of the western Trans-Baikal region were studied. It was found that their concentrations in typical solonchaks of haloxerophytic steppe differed from those in solonchaks of moistened habitats (playa, gleyed, and dark solonchaks) because of the differences in their landscape positions and ecological conditions. A general rise in the contents of the microelements was observed from the northeast to the southwest in agreement with changes in the parent materials. Different degrees of correlation of the contents of the microelements and their exchangeable forms with the contents of soluble salts, humus, and physical clay in the soils and the soil reaction were found. The average and extreme concentrations of the microelements were determined. The studied typical solonchaks differed from the zonal chestnut soils in the higher contents of Co, Cr, and Cd; whereas solonchaks of moistened habitats were enriched in Mn, Co, and Cd.

  15. Trans-oceanic pipeline: reaffirms Panama's strategic position

    SciTech Connect

    Not Available

    1982-11-24

    The Trans-Panama Pipeline, which began in July 1980 and was finished October 1, 1982, will transport Alaskan crude from Puerto Armuelles, in the Pacific Ocean, to Chiriqui Grande, in the Atlantic. Built at a total cost of $400 million, the facility will speed deliveries of North Slope crude to refining centers in Houston, Puerto Rico, the Virgin Islands, and New Jersey; it is expected to move about 800,000 barrels/day by January 1983. With construction of a pump station near Chiriqui Grande, the pipeline could easily be altered for reverse-flow capability. This issue of Energy Detente reviews the use of the new pipeline, as it cuts crude oil transportation time and cost and provides an alternative to the Panama Canal. The issue also updates the fuel price/tax series for the countries of the Western Hemisphere.

  16. Fungal regulatory evolution: cis and trans in the balance

    PubMed Central

    Thompson, Dawn Anne; Regev, Aviv

    2009-01-01

    Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for regulatory evolution studies, due to broad phylogenetic scope, many sequenced genomes, and tractability of genomic analysis. Here we review recent advances in the identification of the contribution of cis and trans factors to expression divergence. Whereas current strategies have led to the discovery of surprising signatures and mechanisms, we still understand very little about the adaptive role of regulatory evolution. Empirical studies including experimental evolution, comparative functional genomics and hybrid and engineered strains are showing early promise toward deciphering the contribution of regulatory divergence to adaptation. PMID:19914250

  17. Resonancias en la región trans-neptuniana

    NASA Astrophysics Data System (ADS)

    Gallardo, T.; Ferraz-Mello, S.

    La expansión de la órbita del planeta Neptuno en la etapa de acreción del Sistema Solar exterior (Fernández e Ip 1984, 1996) parece ser un mecanismo eficiente para la captura de planetesimales en las resonancias exteriores con Neptuno (Malhotra 1995). Por otro lado, los estudios dinámicos realizados por varios autores indican que las resonancias son regiones de evolución estable, en contraste con el comportamiento caótico del resto de la región trans-neptuniana. Por estas razones, y si bien los datos observacionales son todavía muy limitados, se supone que los objetos descubiertos se encuentran en alguna de esas resonancias. En esta comunicación presentamos un estudio analítico y numérico de las principales resonancias exteriores con Neptuno.

  18. Regulation of organismal proteostasis by trans-cellular chaperone signaling

    PubMed Central

    van Oosten-Hawle, Patricija; Porter, Robert S.; Morimoto, Richard I.

    2013-01-01

    Summary A major challenge for metazoans is to ensure that different tissues each expressing distinctive proteomes are, nevertheless, well protected at an organismal level from proteotoxic stress. We have examined this and show that expression of endogenous metastable protein sensors in muscle cells induces a systemic stress response throughout multiple tissues of C. elegans. Suppression of misfolding in muscle cells can be achieved not only by enhanced expression of HSP90 in muscle cells, but as effective by elevated expression of HSP90 in intestine or neuronal cells. This cell-non-autonomous control of HSP90 expression relies upon transcriptional feedback between somatic tissues that is regulated by the FoxA transcription factor PHA-4. This trans-cellular chaperone signaling response maintains organismal proteostasis when challenged by a local tissue imbalance in folding and provides the basis for a novel form of organismal stress sensing surveillance. PMID:23746847

  19. Body dissatisfaction and disordered eating in trans people: A systematic review of the literature.

    PubMed

    Jones, Bethany Alice; Haycraft, Emma; Murjan, Sarah; Arcelus, Jon

    2016-01-01

    Body dissatisfaction plays a prominent role in gender dysphoria. In some individuals body dissatisfaction appears to manifest disordered eating in order to suppress bodily features of natal gender and accentuate features of gender identity. To date, there has been no systematic review of the literature pertaining to body dissatisfaction and disordered eating in trans individuals. Such a review may highlight important implications for clinicians working with trans people. Therefore, the aim was to critically and systematically review the available literature examining body dissatisfaction or disordered eating in a trans population, and also the literature pertaining to how body dissatisfaction and disordered eating are related in trans people. This review found three studies that explored disordered eating in trans people, five studies that explored body image and disordered eating in trans people, and 18 studies that explored body image in trans people. The findings from this review suggest that body dissatisfaction is core to the distress trans people experience and that this dissatisfaction may also put some individuals at risk of developing disordered eating. Additionally, the findings appear to suggest that gender dysphoria treatment is successful at increasing body satisfaction and improving body image. The clinical implications are discussed.

  20. 75 FR 22125 - Trans-Union Interstate Pipeline, L.P.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... Energy Regulatory Commission Trans-Union Interstate Pipeline, L.P.; Notice of Filing April 20, 2010. Take notice that on April 9, 2010 Trans-Union Interstate Pipeline, L.P. submitted a request for waiver of the.... BILLING CODE 6717-01-P...

  1. Low trans spread and shortening oils via hydrogenation of soybean oil

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Soybean oil and cottonseed oil were hydrogenated under selective conditions to yield oils with low iodine values, lowered trans fatty acids and increased stearic acid contents. Oils hydrogenated at 175 deg C, 15 psi hydrogen in the presence of nickel catalyst showed a maximum content of trans fatty...

  2. Broken orthodontic trans-palatal archwire stuck to the throat of orthodontic patient: is it strange?

    PubMed

    Abdel-Kader, H M

    2003-03-01

    Trans-palatal arch wire is in common use in orthodontic practice. This case report of broken trans-palatal wire, swallowed and stuck to the throat of an orthodontic patient, is presented in the hope that it will stress the importance of careful examination of the appliance at each scheduled visit.

  3. 78 FR 26358 - TransCanada Keystone Pipeline, LP; Notice of Petition for Declaratory Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission TransCanada Keystone Pipeline, LP; Notice of Petition for Declaratory Order... and Procedure, 18 CFR 385.207(a)(2)(2012), TransCanada Keystone Pipeline, LP filed a petition...

  4. 75 FR 80482 - Application To Export Electric Energy; TransCanada Power Marketing Ltd.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... Application To Export Electric Energy; TransCanada Power Marketing Ltd. AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of Application. SUMMARY: TransCanada Power Marketing Ltd... electric utilities, Federal power marketing agencies, and other entities within the United States....

  5. Trans-splicing improvement by the combined application of antisense strategies.

    PubMed

    Koller, Ulrich; Hainzl, Stefan; Kocher, Thomas; Hüttner, Clemens; Klausegger, Alfred; Gruber, Christina; Mayr, Elisabeth; Wally, Verena; Bauer, Johann W; Murauer, Eva M

    2015-01-06

    Spliceosome-mediated RNA trans-splicing has become an emergent tool for the repair of mutated pre-mRNAs in the treatment of genetic diseases. RNA trans-splicing molecules (RTMs) are designed to induce a specific trans-splicing reaction via a binding domain for a respective target pre-mRNA region. A previously established reporter-based screening system allows us to analyze the impact of various factors on the RTM trans-splicing efficiency in vitro. Using this system, we are further able to investigate the potential of antisense RNAs (AS RNAs), presuming to improve the trans-splicing efficiency of a selected RTM, specific for intron 102 of COL7A1. Mutations in the COL7A1 gene underlie the dystrophic subtype of the skin blistering disease epidermolysis bullosa (DEB). We have shown that co-transfections of the RTM and a selected AS RNA, interfering with competitive splicing elements on a COL7A1-minigene (COL7A1-MG), lead to a significant increase of the RNA trans-splicing efficiency. Thereby, accurate trans-splicing between the RTM and the COL7A1-MG is represented by the restoration of full-length green fluorescent protein GFP on mRNA and protein level. This mechanism can be crucial for the improvement of an RTM-mediated correction, especially in cases where a high trans-splicing efficiency is required.

  6. UPTAKE AND METABOLISM OF ALL-TRANS RETINOIC ACID BY THREE NATIVE NORTH AMERICAN RANIDS

    EPA Science Inventory

    Retinoids, which are Vvitamin A derivatives, are important signaling molecules that regulate processes critical for development in all vertebrates. The objective of our study was to examine uptake and metabolism of the model retinoid, all-trans retinoic acid (all-trans RA), by th...

  7. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila.

    PubMed

    Abramov, Yuriy A; Shatskikh, Aleksei S; Maksimenko, Oksana G; Bonaccorsi, Silvia; Gvozdev, Vladimir A; Lavrov, Sergey A

    2016-01-01

    Position-effect variegation (PEV) is the epigenetic disruption of gene expression near the de novo-formed euchromatin-heterochromatin border. Heterochromatic cis-inactivation may be accompanied by the trans-inactivation of genes on a normal homologous chromosome in trans-heterozygous combination with a PEV-inducing rearrangement. We characterize a new genetic system, inversion In(2)A4, demonstrating cis-acting PEV as well as trans-inactivation of the reporter transgenes on the homologous nonrearranged chromosome. The cis-effect of heterochromatin in the inversion results not only in repression but also in activation of genes, and it varies at different developmental stages. While cis-actions affect only a few juxtaposed genes, trans-inactivation is observed in a 500-kb region and demonstrates а nonuniform pattern of repression with intermingled regions where no transgene repression occurs. There is no repression around the histone gene cluster and in some other euchromatic sites. trans-Inactivation is accompanied by dragging of euchromatic regions into the heterochromatic compartment, but the histone gene cluster, located in the middle of the trans-inactivated region, was shown to be evicted from the heterochromatin. We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2.

  8. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila

    PubMed Central

    Abramov, Yuriy A.; Shatskikh, Aleksei S.; Maksimenko, Oksana G.; Bonaccorsi, Silvia; Gvozdev, Vladimir A.; Lavrov, Sergey A.

    2016-01-01

    Position-effect variegation (PEV) is the epigenetic disruption of gene expression near the de novo–formed euchromatin-heterochromatin border. Heterochromatic cis-inactivation may be accompanied by the trans-inactivation of genes on a normal homologous chromosome in trans-heterozygous combination with a PEV-inducing rearrangement. We characterize a new genetic system, inversion In(2)A4, demonstrating cis-acting PEV as well as trans-inactivation of the reporter transgenes on the homologous nonrearranged chromosome. The cis-effect of heterochromatin in the inversion results not only in repression but also in activation of genes, and it varies at different developmental stages. While cis-actions affect only a few juxtaposed genes, trans-inactivation is observed in a 500-kb region and demonstrates а nonuniform pattern of repression with intermingled regions where no transgene repression occurs. There is no repression around the histone gene cluster and in some other euchromatic sites. trans-Inactivation is accompanied by dragging of euchromatic regions into the heterochromatic compartment, but the histone gene cluster, located in the middle of the trans-inactivated region, was shown to be evicted from the heterochromatin. We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. PMID:26500261

  9. 77 FR 1676 - EasTrans, LLC; Notice Granting Extension of Time

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission EasTrans, LLC; Notice Granting Extension of Time On December 16, 2011, Eas... an extension of time for EasTrans to file its section 284.123 rate petition is granted to...

  10. Beyond Virtual Equality: Liberatory Consciousness as a Path to Achieve Trans* Inclusion in Higher Education

    ERIC Educational Resources Information Center

    Catalano, D. Chase J.

    2015-01-01

    Trans* men have not, as yet, received specific research attention in higher education. Based on intensive interviews with 25 trans* men enrolled in colleges or universities in New England, I explore their experiences in higher education. I analyze participants' descriptions of supports and challenges in their collegiate environments, as well as…

  11. Resisting Coherence: Trans Men's Experiences and the Use of Grounded Theory Methods

    ERIC Educational Resources Information Center

    Catalano, D. Chase J.

    2017-01-01

    In this methodological reflective manuscript, I explore my decision to use a grounded theoretical approach to my dissertation study on trans* men in higher education. Specifically, I question whether grounded theory as a methodology is capable of capturing the complexity and capaciousness of trans*-masculine experiences. Through the lenses of…

  12. Trans-femoral amputee pilots: criteria for return to the fighter cockpit.

    PubMed

    Grossman, Alon; Goldstein, Liav; Heim, Michael; Barenboim, Erez; Dudkiewicz, Israel

    2005-04-01

    Proximal lower limb amputations (trans-femoral) usually leave amputees with significant functional disturbances. This article contains information regarding three pilots with trans-femoral amputations that returned swiftly to continue their aeronautical careers despite their disabilities. Adaptations are needed in the limb prostheses to enable the amputees to access the minimally spaced cockpit.

  13. Membrane fatty acid composition as a determinant of Listeria monocytogenes sensitivity to trans-cinnamaldehyde.

    PubMed

    Rogiers, Gil; Kebede, Biniam T; Van Loey, Ann; Michiels, Chris W

    2017-03-23

    Trans-cinnamaldehyde, the major compound of cinnamon essential oil, is a potentially interesting natural antimicrobial food preservative. Although a number of studies have addressed its mode of action, the factors that determine bacterial sensitivity or tolerance to trans-cinnamaldehyde are poorly understood. We report the detailed characterization of a Listeria monocytogenes Scott A trans-cinnamaldehyde hypersensitive mutant defective in IlvE, which catalyzes the reversible transamination of branched-chain amino acids to the corresponding short-chain α-ketoacids. This mutant showed an 8.4 fold extended lag phase during growth in sublethal concentrations (4 mM), and faster inactivation in lethal concentrations of trans-cinnamaldehyde (6 mM). Trans-cinnamaldehyde hypersensitivity could be corrected by genetic complementation with the ilvE gene and supplementation with branched-chain α-ketoacids. Whole-cell fatty acid analyses revealed an almost complete loss of anteiso branched-chain fatty acids (BCFAs), which was compensated by elevated levels of unbranched saturated fatty acids and iso-BCFAs. Sub-inhibitory concentrations of trans-cinnamaldehyde induced membrane fatty acid adaptations predicted to reduce membrane fluidity, possibly as a response to counteract the membrane fluidizing effect of trans-cinnamaldehyde. These results demonstrate the role of IlvE in BCFA production and the role of membrane composition as an important determinant of trans-cinnamaldehyde sensitivity in L. monocytogenes.

  14. Dietary Trans Fatty Acids and Cardiovascular Disease Risk: Past and Present

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dietary trans double bond fatty acids have been associated with increased risk of cardiovascular disease. There are two main sources of dietary trans fatty acids: meat and dairy fats, and partially-hydrogenated oils. Due to a number of factors, including changes in federal labeling requirements fo...

  15. 76 FR 28221 - Trans-Union Interstate Pipeline, L.P.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... Energy Regulatory Commission Trans-Union Interstate Pipeline, L.P.; Notice of Filing Take notice that on April 7, 2011 Trans-Union Interstate Pipeline, L.P. submitted a request for a waiver of the reporting...-8659. Comment Date: June 9, 2011. Dated: May 10, 2011. Kimberly Bose, Secretary. BILLING CODE 6717-01-P...

  16. Structural Elucidation of cis/trans Dicaffeoylquinic Acid Photoisomerization Using Ion Mobility Spectrometry-Mass Spectrometry.

    PubMed

    Zheng, Xueyun; Renslow, Ryan S; Makola, Mpho M; Webb, Ian K; Deng, Liulin; Thomas, Dennis G; Govind, Niranjan; Ibrahim, Yehia M; Kabanda, Mwadham M; Dubery, Ian A; Heyman, Heino M; Smith, Richard D; Madala, Ntakadzeni E; Baker, Erin S

    2017-04-06

    Due to the recently uncovered health benefits and anti-HIV activities of dicaffeoylquinic acids (diCQAs), understanding their structures and functions is of great interest for drug discovery efforts. DiCQAs are analytically challenging to identify and quantify since they commonly exist as a diverse mixture of positional and geometric (cis/trans) isomers. In this work, we utilized ion mobility spectrometry coupled with mass spectrometry to separate the various isomers before and after UV irradiation. The experimental collision cross sections were then compared with theoretical structures to differentiate and identify the diCQA isomers. Our analyses found that naturally the diCQAs existed predominantly as trans/trans isomers, but after 3 h of UV irradiation, cis/cis, cis/trans, trans/cis, and trans/trans isomers were all present in the mixture. This is the first report of successful differentiation of cis/trans diCQA isomers individually, which shows the great promise of IMS coupled with theoretical calculations for determining the structure and activity relationships of different isomers in drug discovery studies.

  17. Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation.

    PubMed

    Herth, Matthias M; Andersen, Valdemar L; Lehel, Szabolcs; Madsen, Jacob; Knudsen, Gitte M; Kristensen, Jesper L

    2013-05-08

    Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.

  18. Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature.

    PubMed

    Zupančič, Špela; Lavrič, Zoran; Kristl, Julijana

    2015-06-01

    Recently trans-resveratrol (trans-RSV) has received great attention due to its prophylactic and therapeutic properties. Its limited bioavailability provides compelling evidence of the need for more suitable formulations in order to attain better clinical effectiveness. Some physicochemical properties of trans-RSV are still unknown or research findings are contradictory. Therefore, this paper presents newly determined trans-RSV solubility and stability at various pH and temperatures, and the importance of such data for the studies of novel trans-RSV-loaded nanofibers. In acidic pH trans-RSV was stable, whereas its degradation started to increase exponentially above pH 6.8. Consequently, it is worthwhile to note that special consideration has to be dedicated to long dissolution testing or biological assays on cell lines in order to obtain relevant data. Measurements were done by validated UV/VIS spectroscopy, HPLC, and newly developed UPLC methods. Specificity was confirmed for HPLC and UPLC method, whereas UV/VIS spectroscopy resulted in false higher trans-RSV concentrations in conditions under which it was not stable (alkaline pH, light, increased temperature). The study is of interest because it draws attention to the importance of careful selected experimental conditions, their influence on the trans-RSV stability and the implications this has for formulation development, storage, and maintenance of therapeutic doses.

  19. Trans beta substituted chlorins and methods of making and using the same

    DOEpatents

    Lindsey, Jonathan S.; Balasubramanian, Thiagarajan

    2003-05-06

    Trans beta substituted chlorins and methods of making the same are disclosed, along with polymers formed from or containing such trans beta substituted chlorins as one or more monomeric units therein, light harvesting rods formed from such polymers, and electrodes carrying such polymers.

  20. Design of Trypanosoma rangeli sialidase mutants with improved trans-sialidase activity

    PubMed Central

    Nyffenegger, Christian; Nordvang, Rune Thorbjørn; Meyer, Anne S.; Mikkelsen, Jørn Dalgaard

    2017-01-01

    A sialidase (EC 3.2.1.18) from the non-pathogenic Trypanosoma rangeli, TrSA, has been shown to exert trans-sialidase activity after mutation of five specific amino acids in the active site (M96V, A98P, S120Y, G249Y, Q284P) to form the so-called TrSA5mut enzyme. By computational and hypothesis driven approaches additional mutations enhancing the trans-sialidase activity have been suggested. In the present work, we made a systematic combination of these mutations leading to seven new variants of the T. rangeli sialidase, having 6–16 targeted amino acid mutations. The resulting enzyme variants were analyzed via kinetics for their ability to carry out trans-sialidase reaction using CGMP and D-lactose as substrates. The sialidase variants with 15 and 16 mutations, respectively, exhibited significantly improved trans-sialidase activity for D-lactose sialylation. Our results corroborate, that computational studies of trans-glycosylation can be a valuable input in the design of novel trans-glycosidases, but also highlight the importance of experimental validation in order to assess the performance. In conclusion, two of the seven mutants displayed a dramatic switch in specificity from hydrolysis towards trans-sialylation and constitute the most potent trans-sialidase mutants of TrSA described in literature to date. PMID:28158299

  1. Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing

    PubMed Central

    Trochet, Delphine; Prudhon, Bernard; Jollet, Arnaud; Lorain, Stéphanie; Bitoun, Marc

    2016-01-01

    Dynamin 2 (DNM2) is a large GTPase, ubiquitously expressed, involved in membrane trafficking and regulation of actin and microtubule cytoskeletons. DNM2 mutations cause autosomal dominant centronuclear myopathy which is a rare congenital myopathy characterized by skeletal muscle weakness and histopathological features including nuclear centralization in absence of regeneration. No curative treatment is currently available for the DNM2-related autosomal dominant centronuclear myopathy. In order to develop therapeutic strategy, we evaluated here the potential of Spliceosome-Mediated RNA Trans-splicing technology to reprogram the Dnm2-mRNA in vitro and in vivo in mice. We show that classical 3′-trans-splicing strategy cannot be considered as accurate therapeutic strategy regarding toxicity of the pre-trans-splicing molecules leading to low rate of trans-splicing in vivo. Thus, we tested alternative strategies devoted to prevent this toxicity and enhance frequency of trans-splicing events. We succeeded to overcome the toxicity through a 5′-trans-splicing strategy which also allows detection of trans-splicing events at mRNA and protein levels in vitro and in vivo. These results suggest that the Spliceosome-Mediated RNA Trans-splicing strategy may be used to reprogram mutated Dnm2-mRNA but highlight the potential toxicity linked to the molecular tools which have to be carefully investigated during preclinical development. PMID:27623444

  2. Application of E-Learning to Pilot Training at TransAsia Airways in Taiwan

    ERIC Educational Resources Information Center

    Chuang, Chi-Kuo; Chang, Maiga; Wang, Chin-Yeh; Chung, Wen-Cheng; Chen, Gwo-Dong

    2008-01-01

    TransAsia Airway is one of the four domestic airlines in Taiwan. Taiwan has 13 domestic airports with the longest distance between two airports being about 400 kilometers. The domestic airline market is highly competitive. TransAsia decided to apply e-learning within its organization to reduce training expenses and improve service quality. This…

  3. Conformer of the peroxynitrite ion formed under photolysis of crystalline alkali nitrates – cis or trans?

    NASA Astrophysics Data System (ADS)

    Pak, V. Kh; Anan’ev, V. A.; Dyagileva, E. P.; Lyrshchikov, S. Yu; Miklin, M. B.; Rezvova, M. A.

    2017-01-01

    The optical and infrared reflectance spectra of the crystalline powders prepared by co-crystallization of caesium nitrate, nitrite, and peroxynitrite from alkali solution have been studied. We find that the trans conformer forms under photolysis of crystalline pure caesium nitrate. Under its dissolution the trans conformer transforms to the cis conformer.

  4. Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer

    PubMed Central

    Zhu, Weizhu; Qin, Wenyi; Zhang, Ke; Rottinghaus, George E.; Chen, Yin-Chieh; Kliethermes, Beth; Sauter, Edward R.

    2012-01-01

    Trans-resveratrol, present in high concentration in the skin of red grapes and red wine, has a dose-dependent antiproliferative effect in vitro, prevents the formation of mammary tumors, and has been touted as a chemopreventive agent. Based upon in vitro studies demonstrating that trans-resveratrol downregulates the expression of 1) DNA methyltransferases and 2) the cancer promoting prostaglandin (PG)E2, we determined if trans-resveratrol had a dose-related effect on DNA methylation and prostaglandin expression in humans. Thirty-nine adult women at increased breast cancer risk were randomized in double-blind fashion to placebo, 5 or 50 mg trans-resveratrol twice daily for 12 wk. Methylation assessment of 4 cancer-related genes (p16, RASSF-1α, APC, CCND2) was performed on mammary ductoscopy specimens. The predominant resveratrol species in serum was the glucuronide metabolite. Total trans-resveratrol and glucuronide metabolite serum levels increased after consuming both trans-resveratrol doses (P < .001 for both). RASSF-1α methylation decreased with increasing levels of serum trans-resveratrol (P = .047). The change in RASSF-1α methylation was directly related to the change in PGE2 (P = .045). This work provides novel insights into the effects of trans-resveratrol on the breast of women at increased breast cancer risk, including a decrease in methylation of the tumor suppressor gene RASSF-1α. Because of the limited sample size, our findings should be validated in a larger study. PMID:22332908

  5. Changes in Trans Fat and Fatty Acids in Fast Food Menu Items

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recent interest in trans fatty acid intake and subsequent recommendations included in the 2005 Dietary Guidelines for Americans to decrease intake has led to extensive product reformulations of widely consumed foods high in trans fat. As part of these efforts to provide current and accurate nutrien...

  6. Trans-dimensional Bayesian inference for large sequential data sets

    NASA Astrophysics Data System (ADS)

    Mandolesi, E.; Dettmer, J.; Dosso, S. E.; Holland, C. W.

    2015-12-01

    This work develops a sequential Monte Carlo method to infer seismic parameters of layered seabeds from large sequential reflection-coefficient data sets. The approach provides parameter estimates and uncertainties along survey tracks with the goal to aid in the detection of unexploded ordnance in shallow water. The sequential data are acquired by a moving platform with source and receiver array towed close to the seabed. This geometry requires consideration of spherical reflection coefficients, computed efficiently by massively parallel implementation of the Sommerfeld integral via Levin integration on a graphics processing unit. The seabed is parametrized with a trans-dimensional model to account for changes in the environment (i.e. changes in layering) along the track. The method combines advanced Markov chain Monte Carlo methods (annealing) with particle filtering (resampling). Since data from closely-spaced source transmissions (pings) often sample similar environments, the solution from one ping can be utilized to efficiently estimate the posterior for data from subsequent pings. Since reflection-coefficient data are highly informative, the likelihood function can be extremely peaked, resulting in little overlap between posteriors of adjacent pings. This is addressed by adding bridging distributions (via annealed importance sampling) between pings for more efficient transitions. The approach assumes the environment to be changing slowly enough to justify the local 1D parametrization. However, bridging allows rapid changes between pings to be addressed and we demonstrate the method to be stable in such situations. Results are in terms of trans-D parameter estimates and uncertainties along the track. The algorithm is examined for realistic simulated data along a track and applied to a dataset collected by an autonomous underwater vehicle on the Malta Plateau, Mediterranean Sea. [Work supported by the SERDP, DoD.

  7. Nutritional profile of phytococktail from trans-Himalayan plants.

    PubMed

    Dhar, Priyanka; Tayade, Amol B; Kumar, Jatinder; Chaurasia, Om P; Srivastava, Ravi B; Singh, Shashi B

    2013-01-01

    We estimated the nutritive value, vitamin content, amino acid composition, fatty acid content, and mineral profile of a phytococktail comprising sea buckthorn (Hippophae rhamnoides), apricot (Prunus armeniaca), and roseroot (Rhodiola imbricata) from trans-Himalaya. The free vitamin forms in the phytococktail were determined by rapid resolution liquid chromatography/tandem mass spectrometry (RRLC-MS/MS). Vitamin E and B-complex vitamins were detected as the principle vitamins. Reversed-phase high performance liquid chromatography (RP-HPLC) with pre-column derivatization was used for identification and quantification of amino acids. Eight essential and eleven non-essential amino acids were quantified, and the content ranged between 76.33 and 9485.67 µg/g. Among the essential amino acids, L-methionine, L-phenylalanine, L-lysine, L-leucine, and L-histidine were found to be the dominant contributors. We also quantified the fatty acids in the phytococktail by using gas chromatography coupled with a flame ionization detector (GC-FID) with fatty acid methyl esters (FAMEs) derivatization. The analysis revealed the presence of 4 major fatty acids contributing to the total lipid content. Palmitic acid was found to be the rich source of saturated fatty acid (SFA) and constituted ∼31% of the total lipid content. Among the unsaturated fatty acids (UFAs), palmitoleic acid (43.47%), oleic acid (20.89%), and linoleic acid (4.31%) were prominent. The mineral profiling was carried out by inductively coupled plasma optical emission spectrometer (ICP-OES), and it was found to contain a number of important dietary mineral elements. The harsh climatic conditions, difficult terrain, and logistic constraints at high altitude regions of Indian trans-Himalayan cold desert lead to the scarcity of fresh fruits and vegetables. Therefore, the source of multiple vitamins, essential amino acids, fatty acids, and dietary minerals from the phytococktail would provide great health benefit in the

  8. Searching for trans ethyl methyl ether in Orion KL(.)

    PubMed

    Tercero, B; Cernicharo, J; López, A; Brouillet, N; Kolesniková, L; Motiyenko, R A; Margulès, L; Alonso, J L; Guillemin, J-C

    2015-10-01

    We report on the tentative detection of trans ethyl methyl ether (tEME), t-CH3CH2OCH3, through the identification of a large number of rotational lines from each one of the spin states of the molecule towards Orion KL. We also search for gauche-trans-n-propanol, Gt-n-CH3CH2CH2OH, an isomer of tEME in the same source. We have identified lines of both species in the IRAM 30 m line survey and in the ALMA Science Verification data. We have obtained ALMA maps to establish the spatial distribution of these species. Whereas tEME mainly arises from the compact ridge component of Orion, Gt-n-propanol appears at the emission peak of ethanol (south hot core). The derived column densities of these species at the location of their emission peaks are ≤(4.0 ± 0.8) × 10(15) cm(-2) and ≤(1.0 ± 0.2)× 10(15) cm(-2) for tEME and Gt-n-propanol, respectively. The rotational temperature is ~100 K for both molecules. We also provide maps of CH3OCOH, CH3CH2OCOH, CH3OCH3, CH3OH, and CH3CH2OH to compare the distribution of these organic saturated O-bearing species containing methyl and ethyl groups in this region. Abundance ratios of related species and upper limits to the abundances of non-detected ethers are provided. We derive an abundance ratio N(CH3OCH3)/N(tEME) ≥ 150 in the compact ridge of Orion.

  9. Ruminant and industrially produced trans fatty acids: health aspects

    PubMed Central

    Stender, Steen; Astrup, Arne; Dyerberg, Jørn

    2008-01-01

    Fatty acids of trans configuration in our food come from two different sources – industrially produced partially hydrogenated fat (IP-TFA) used in frying oils, margarines, spreads, and in bakery products, and ruminant fat in dairy and meat products (RP-TFA). The first source may contain up to 60% of the fatty acids in trans form compared to the content in ruminant fat which generally does not exceed 6%. In Western Europe, including Scandinavia, the average daily intake of IP-TFA has decreased during the recent decade due to societal pressure and a legislative ban, whereas the intake of RP-TFA has remained stable. In spite of this decrease we have found that in many countries consumption >20 g of IP-TFA in a one-meal menu consisting of some popular foods is possible, even though the average intake of IP-TFA in these countries is low. Subgroups of the populations may therefore, on average, consume >5 g IP-TFA per day. This level of consumption is generally not possible for RP-TFA. A daily intake of 5 g TFA (primarily IP-TFA) is associated with a 29% increased risk of coronary heart disease. Such an association is not found for RP-TFA up to a daily intake of 4 g. The high amount of IP-TFA in popular foods, the evidence of a more harmful effect on health by IP-TFA than by RP-TFA, and the feasibility of eliminating IP-TFA from foods without side effects for the population, suggest that a selective elimination of IP-TFA from our food is a ‘low hanging fruit’ in the quest for a more healthy diet for subgroups of the population. PMID:19109659

  10. Macroscopic Quantum Coherence and Computing

    DTIC Science & Technology

    2010-02-17

    A. Gubrud, A. J. Berkley, J. R. Anderson, C. J. Lobb, and F. C. Wellstood, IEEE Trans AppI Supr 11,998 (2001) [2] J. M. Martinis, S. Nam, J. Aumentado...al., Phys. Rev. Lett. 87, 217003 (2001) [5] M. Savolainen, et. al., to be published in Appi . Phys. A (2004), cond-mat/031 1383 Modelling the current

  11. Trans-Stilbenes in Commercial Grape Juices: Quantification Using HPLC Approaches

    PubMed Central

    López-Hernández, Julia; Rodríguez-Bernaldo de Quirós, Ana

    2016-01-01

    Trans-stilbenes belong to the group of polyphenolic phytoalexins, and occur in many plant foods. These compounds have received great attention by researchers due to their well-known beneficial health effects. In the present study a chromatographic method that comprises the use of variable wavelength (VWD) and fluorescence (FLD) detectors in series for the analysis of trans-stilbenes is presented. The relation of peak-area obtained with both detectors is proposed as an alternative and complementary approach for the rapid identification of these phenolic compounds. The proposed method was applied to determine trans-stilbenes in commercial fruit juices. Trans-piceid was the most common trans-stilbene found in the samples analyzed. The method was validated in terms of linearity, sensitivity and repeatability. Appropriate sensitivity and good linearity (r2 > 0.9991) were achieved. PMID:27783052

  12. Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system.

    PubMed

    Xu, Ying; Wang, Zhichao; You, Wenting; Zhang, Xiuhua; Li, Shan; Barish, Philip A; Vernon, Matthew M; Du, Xia; Li, Gaowen; Pan, Jianchun; Ogle, William O

    2010-06-01

    The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80 mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation.

  13. An Improved Approach for RSSI-Based only Calibration-Free Real-Time Indoor Localization on IEEE 802.11 and 802.15.4 Wireless Networks.

    PubMed

    Passafiume, Marco; Maddio, Stefano; Cidronali, Alessandro

    2017-03-29

    Assuming a reliable and responsive spatial contextualization service is a must-have in IEEE 802.11 and 802.15.4 wireless networks, a suitable approach consists of the implementation of localization capabilities, as an additional application layer to the communication protocol stack. Considering the applicative scenario where satellite-based positioning applications are denied, such as indoor environments, and excluding data packet arrivals time measurements due to lack of time resolution, received signal strength indicator (RSSI) measurements, obtained according to IEEE 802.11 and 802.15.4 data access technologies, are the unique data sources suitable for indoor geo-referencing using COTS devices. In the existing literature, many RSSI based localization systems are introduced and experimentally validated, nevertheless they require periodic calibrations and significant information fusion from different sensors that dramatically decrease overall systems reliability and their effective availability. This motivates the work presented in this paper, which introduces an approach for an RSSI-based calibration-free and real-time indoor localization. While switched-beam array-based hardware (compliant with IEEE 802.15.4 router functionality) has already been presented by the author, the focus of this paper is the creation of an algorithmic layer for use with the pre-existing hardware capable to enable full localization and data contextualization over a standard 802.15.4 wireless sensor network using only RSSI information without the need of lengthy offline calibration phase. System validation reports the localization results in a typical indoor site, where the system has shown high accuracy, leading to a sub-metrical overall mean error and an almost 100% site coverage within 1 m localization error.

  14. /Cu-Al System

    NASA Astrophysics Data System (ADS)

    Kish, Orel; Froumin, Natalya; Aizenshtein, Michael; Frage, Nachum

    2014-05-01

    Wettability and interfacial interaction of the Ta2O5/Cu-Al system were studied. Pure Cu does not wet the Ta2O5 substrate, and improved spreading is achieved when relatively a high fraction of the active element (~40 at.% Al) was added. The Al2O3 and AlTaO4 phases were observed at the Ta2O5/Cu-Al interface. A thermodynamic evaluation allowed us to suggest that the lack of wetting bellow 40 at.% Al is due to the presence of a native oxide, which covers the drop. The conditions of the native oxide decomposition and the formation of the volatile Al2O suboxide strongly depend on the vacuum level during sessile drop experiments and the composition of the Cu-Al alloy. In our case, Al contents greater than 40% provides thermodynamic conditions for the formation of Al2O (as a result of Al reaction with Al2O3) and the drop spreading. It was suggested that the final contact angle in the Ta2O5/Cu-Al system (50°) is determined by Ta adsorption on the newly formed alumina interlayer.

  15. A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila.

    PubMed

    Gao, Jun-Li; Fan, Yu-Jie; Wang, Xiu-Ye; Zhang, Yu; Pu, Jia; Li, Liang; Shao, Wei; Zhan, Shuai; Hao, Jianjiang; Xu, Yong-Zhen

    2015-04-01

    Unlike typical cis-splicing, trans-splicing joins exons from two separate transcripts to produce chimeric mRNA and has been detected in most eukaryotes. Trans-splicing in trypanosomes and nematodes has been characterized as a spliced leader RNA-facilitated reaction; in contrast, its mechanism in higher eukaryotes remains unclear. Here we investigate mod(mdg4), a classic trans-spliced gene in Drosophila, and report that two critical RNA sequences in the middle of the last 5' intron, TSA and TSB, promote trans-splicing of mod(mdg4). In TSA, a 13-nucleotide (nt) core motif is conserved across Drosophila species and is essential and sufficient for trans-splicing, which binds U1 small nuclear RNP (snRNP) through strong base-pairing with U1 snRNA. In TSB, a conserved secondary structure acts as an enhancer. Deletions of TSA and TSB using the CRISPR/Cas9 system result in developmental defects in flies. Although it is not clear how the 5' intron finds the 3' introns, compensatory changes in U1 snRNA rescue trans-splicing of TSA mutants, demonstrating that U1 recruitment is critical to promote trans-splicing in vivo. Furthermore, TSA core-like motifs are found in many other trans-spliced Drosophila genes, including lola. These findings represent a novel mechanism of trans-splicing, in which RNA motifs in the 5' intron are sufficient to bring separate transcripts into close proximity to promote trans-splicing.

  16. Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity

    PubMed Central

    Van heusden, J; Van Ginckel, R; Bruwiere, H; Moelans, P; Janssen, B; Floren, W; van der Leede, B J; van Dun, J; Sanz, G; Venet, M; Dillen, L; Van Hove, C; Willemsens, G; Janicot, M; Wouters, W

    2002-01-01

    All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of resistance, believed to be caused by increased all-trans-retinoic acid metabolism. Inhibitors of all-trans-retinoic acid metabolism may therefore prove valuable in the treatment of cancer. In this study, we characterize R116010 as a new anticancer drug that is a potent inhibitor of all-trans-retinoic acid metabolism. In vitro, R116010 potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with an IC50-value of 8.7 nM. In addition, R116010 is a selective inhibitor as indicated by its inhibition profile for several other cytochrome P450-mediated reactions. In T47D cell proliferation assays, R116010 by itself has no effect on cell proliferation. However, in combination with all-trans-retinoic acid, R116010 enhances the all-trans-retinoic acid-mediated antiproliferative activity in a concentration-dependent manner. In vivo, the growth of murine oestrogen-independent TA3-Ha mammary tumours is significantly inhibited by R116010 at doses as low as 0.16 mg kg−1. In conclusion, R116010 is a highly potent and selective inhibitor of all-trans-retinoic acid metabolism, which is able to enhance the biological activity of all-trans-retinoic acid, thereby exhibiting antitumour activity. R116010 represents a novel and promising anticancer drug with an unique mechanism of action. British Journal of Cancer (2002) 86, 605–611. DOI: 10.1038/sj/bjc/6600056 www.bjcancer.com © 2002 Cancer Research UK PMID:11870544

  17. Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.

    PubMed

    Van Heusden, J; Van Ginckel, R; Bruwiere, H; Moelans, P; Janssen, B; Floren, W; van der Leede, B J; van Dun, J; Sanz, G; Venet, M; Dillen, L; Van Hove, C; Willemsens, G; Janicot, M; Wouters, W

    2002-02-12

    All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of resistance, believed to be caused by increased all-trans-retinoic acid metabolism. Inhibitors of all-trans-retinoic acid metabolism may therefore prove valuable in the treatment of cancer. In this study, we characterize R116010 as a new anticancer drug that is a potent inhibitor of all-trans-retinoic acid metabolism. In vitro, R116010 potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with an IC(50)-value of 8.7 nM. In addition, R116010 is a selective inhibitor as indicated by its inhibition profile for several other cytochrome P450-mediated reactions. In T47D cell proliferation assays, R116010 by itself has no effect on cell proliferation. However, in combination with all-trans-retinoic acid, R116010 enhances the all-trans-retinoic acid-mediated antiproliferative activity in a concentration-dependent manner. In vivo, the growth of murine oestrogen-independent TA3-Ha mammary tumours is significantly inhibited by R116010 at doses as low as 0.16 mg kg(-1). In conclusion, R116010 is a highly potent and selective inhibitor of all-trans-retinoic acid metabolism, which is able to enhance the biological activity of all-trans-retinoic acid, thereby exhibiting antitumour activity. R116010 represents a novel and promising anticancer drug with an unique mechanism of action.

  18. Dehalogenation Activity of Selected Fungi Toward δ-Iodo-γ-Lactone Derived from trans,trans-Farnesol.

    PubMed

    Gliszczyńska, Anna; Gładkowski, Witold; Świtalska, Marta; Wietrzyk, Joanna; Szumny, Antoni; Gębarowska, Elżbieta; Wawrzeńczyk, Czesław

    2016-04-01

    Time-course of biotransformation of racemic trans-4-((E)-4',8'-dimethylnona-3',7'-dien-1-yl)-5-iodomethyl-4-methyldihydrofuran-2-one (1) in fungal and yeast cultures was investigated. In these conditions, the substrate 1 was enantioselectively dehalogenated yielding 4-((E)-4',8'-dimethylnona-3',7'-dien-1-yl)-4-methyl-5-methylenedihydrofuran-2-one (2) and its structure was established based on the spectroscopic data. The most effective biocatalyst used was Didymosphaeria igniaria, which catalyzed the process with highest rate and enantioselectivity (ee of product = 76%). The antiproliferative activity of δ-iodo-γ-lactone 1, product of its biotransformation 2, and starting substrate (farnesol) were evaluated toward two cancer cell lines: A549 (human lung adenocarcinoma) and HL-60 (human promyelocytic leukemia).

  19. Cis-9, trans-11 and trans-10, cis-12 CLA mixture does not change body composition, induces insulin resistance and increases serum HDL cholesterol level in rats.

    PubMed

    de Almeida, Mariana Macedo; de Souza, Yamara Oliveira; Dutra Luquetti, Sheila Cristina Potente; Sabarense, Céphora Maria; do Amaral Corrêa, José Otávio; da Conceição, Ellen Paula Santos; Lisboa, Patrícia Cristina; de Moura, Egberto Gaspar; Andrade Soares, Sara Malaguti; Moura Gualberto, Ana Cristina; Gameiro, Jacy; da Gama, Marco Antônio Sundfeld; Ferraz Lopes, Fernando César; González Garcia, Raúl Marcel

    2015-01-01

    Synthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture of cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety of this CLA mixture is controversial and in some countries the CLA usage as food supplement is not authorized. Changes in insulinemic control and serum lipids profile are potential negative effects related to consumption of CLA mixture. The present study aimed to evaluate the effects of a diet containing mixture of cis-9, trans-11 and trans-10, cis-12 CLA on prevention of obesity risk as well as on potential side effects such as insulin resistance and dyslipidemia in Wistar rats. Thirty male Wistar rats were randomly assigned to the following dietary treatments (n=10/group), for 60 days: Normolipidic Control (NC), diet containing 4.0% soybean oil (SO); High Fat-Control (HF-C), diet containing 24.0% SO; High Fat-synthetic CLA (HF-CLA), diet containing 1.5% of an isomeric CLA mixture (Luta-CLA 60) and 22.5% SO. Luta-CLA 60 (BASF) contained nearly 60% of CLA (cis-9, trans-11 and trans-10, cis-12 CLA at 50:50 ratio). The HF-CLA diet contained 0.3% of each CLA isomer. HF-CLA diet had no effect on dietary intake and body composition. HF-CLA-fed rats had lower levels of PPARγ protein in retroperitoneal adipose tissue, hyperinsulinemia compared to HF-C-fed rats, hyperglycemia compared to NC-fed rats while no differences in glycemia were observed between NC and HF-C groups, increased HOMA index and higher levels of serum HDL cholesterol. Thus, feeding rats with a high fat diet containing equal parts of cis-9, trans-11 and trans-10, cis-12 CLA isomers had no effect on body composition and induced insulin resistance. Despite HF-CLA-fed rats had increased serum HDL cholesterol levels, caution should be taken before synthetic supplements containing cis-9, trans-11 and trans-10, cis-12 CLA are recommended as a nutritional strategy for weight management.

  20. Initial Symptoms of ALS

    MedlinePlus

    ... Chapters Certified Centers and Clinics Support Groups About ALS About Us Our Research In Your Community Advocate ... Diagnosis En español Symptoms The initial symptoms of ALS can be quite varied in different people. One ...

  1. Lou Gehrig's Disease (ALS)

    MedlinePlus

    ... 1930s. People in England and Australia call ALS motor neurone disease (MND). The French refer to it ... about ALS in 1869. Lou Gehrig's disease damages motor neurons in the brain and spinal cord. Motor ...

  2. The conjugated linoleic acid isomer trans-9,trans-11 is a dietary occurring agonist of liver X receptor {alpha}

    SciTech Connect

    Ecker, Josef; Liebisch, Gerhard; Patsch, Wolfgang; Schmitz, Gerd

    2009-10-30

    Conjugated linoleic acid (CLA) isomers are dietary fatty acids that modulate gene expression in many cell types. We have previously reported that specifically trans-9,trans-11 (t9,t11)-CLA induces expression of genes involved in lipid metabolism of human macrophages. To elucidate the molecular mechanism underlying this transcriptional activation, we asked whether t9,t11-CLA affects activity of liver X receptor (LXR) {alpha}, a major regulator of macrophage lipid metabolism. Here we show that t9,t11-CLA is a regulator of LXR{alpha}. We further demonstrate that the CLA isomer induces expression of direct LXR{alpha} target genes in human primary macrophages. Knockdown of LXR{alpha} with RNA interference in THP-1 cells inhibited t9,t11-CLA mediated activation of LXR{alpha} including its target genes. To evaluate the effective concentration range of t9,t11-CLA, human primary macrophages were treated with various doses of CLA and well known natural and synthetic LXR agonists and mRNA expression of ABCA1 and ABCG1 was analyzed. Incubation of human macrophages with 10 {mu}M t9,t11-CLA led to a significant modulation of ABCA1 and ABCG1 transcription and caused enhanced cholesterol efflux to high density lipoproteins and apolipoprotein AI. In summary, these data show that t9,t11-CLA is an agonist of LXR{alpha} in human macrophages and that its effects on macrophage lipid metabolism can be attributed to transcriptional regulations associated with this nuclear receptor.

  3. Benzene exposure, assessed by urinary trans,trans-muconic acid, in urban children with elevated blood lead levels.

    PubMed Central

    Weaver, V M; Davoli, C T; Heller, P J; Fitzwilliam, A; Peters, H L; Sunyer, J; Murphy, S E; Goldstein, G W; Groopman, J D

    1996-01-01

    A pilot study was performed to evaluate the feasibility of using trans,trans-muconic acid (MA) as a biomarker of environmental benzene exposure. A secondary aim was to provide data on the extent of exposure to selected toxicants in a unique population consisting of inner-city children who were already overexposed to one urban hazard, lead. Potential sources of benzene were assessed by a questionnaire. Exposure biomarkers included urinary MA and cotinine and blood lead. Mean MA was 176.6 +/- 341.7 ng/mg creatinine in the 79 children who participated. A wide range of values was found with as many as 10.1%, depending on the comparison study, above the highest levels reported in adults not exposed by occupation. Mean MA was increased in children evaluated in the afternoon compared to morning, those at or above the median for time spent playing near the street, and those studied in the first half of the investigation. MA levels were not associated with blood lead or, consistently, with either questionnaire environmental tobacco smoke (ETS) data or cotinine. As expected, the mean blood lead level was elevated (23.6 micrograms/dl). Mean cotinine was also increased at 79.2 ng/mg creatinine. We conclude that the use of MA as a biomarker for environmental benzene exposure is feasible since it was detectable in 72% of subjects with a wide range of values present. In future studies, correlation of MA with personal air sampling in environmental exposure will be essential to fully interpret the significance of these findings. In addition, these inner-city children comprise a high risk group for exposure to environmental toxicants including ETS, lead, and probably benzene, based on questionnaire sources and its presence in ETS. Images Figure 1. Figure 2. Figure 3. Figure 4. Figure 4. Figure 5. PMID:8919771

  4. Trans, trans-2,4-decadienal induced cell proliferation via p27 pathway in human bronchial epithelial cells

    SciTech Connect

    Chang, Y.-C.; Lin Pinpin

    2008-04-01

    Lung cancer is the leading cause of cancer deaths worldwide. Epidemiological studies have shown that exposure to cooking oil fumes (COF) is a risk factor for lung cancer. Trans, trans-2,4-decadienal (tt-DDE), a dienaldehyde, is abundant in heated oils and COF. Previously, we found that long-term exposure (45 days) to a sub-lethal dose (1 {mu}M) of tt-DDE significantly increased growth of human bronchial epithelial cells (BEAS-2B). Aims of this study are to understand the mechanism of tt-DDE-induced cell proliferation and possible protective effects of antioxidant, vitamin C and N-acetylcysteine (NAC) in BEAS-2B cells. Utilizing the real-time RT-PCR and Western immunoblotting, we found that p27 mRNA and protein levels were significantly increased by 1 {mu}M tt-DDE treatment. Co-treatment with vitamin C or NAC partially prevented tt-DDE-induced cell proliferation. In addition, the downstream targets of p27, including CDK4, cyclin D{sub 1} and phosphorylated-Rb proteins, increased in 1 {mu}M tt-DDE-treated cells and these changes were prevented by NAC co-treatment. Therefore, these results suggest that tt-DDE increased cell proliferation via inhibition of p27 expression, increase in CDK4/cyclin D{sub 1} protein accumulation and enhancement of Rb phosphorylation. Increased cell proliferation is considered as the early stages of lung carcinogenesis. Administration of antioxidants may prevent COF-associated lung carcinogenesis.

  5. Adaptive Topological Configuration of an Integrated Circuit/Packet-Switched Computer Network.

    DTIC Science & Technology

    1984-01-01

    Gitman et al. [45] state that there are basically two approaches to the integrated network design problem: (1) solve the link/capacity problem for...1972), 1385-1397. 33. Frank, H., and Gitman , I. Economic analysis of integrated voice and data networks: a case study. Proc. of IEEE 66 , 11 (Nov. 1978...1974), 1074-1079. 45. Gitman , I., Hsieh, W., and Occhiogrosso, B. J. Analysis and design of hybrid switching networks. IEEE Trans. on Comm. Com-29

  6. On modeling the pressure-dependent photoisomerization of trans-stilbene by including slow intramolecular vibrational energy redistribution.

    PubMed

    Weston, Ralph E; Barker, John R

    2006-06-29

    Experimental data for the photoisomerization of trans-stilbene (S(1)) in thermal bath gases at pressures up to 20 bar obtained previously by Meyer, Schroeder, and Troe (J. Phys. Chem. A 1999, 103, 10528-10539) are modeled by using a full collisional-reaction master equation that includes non-RRKM (Rice-Ramsperger-Kassel-Marcus) effects due to slow intramolecular vibrational energy redistribution (IVR). The slow IVR effects are modeled by incorporating the theoretical results obtained recently by Leitner et al. (J. Phys. Chem. A 2003, 107, 10706-10716), who used the local random matrix theory. The present results show that the experimental rate constants of Meyer et al. are described to within about a factor of 2 over much of the experimental pressure range. However, a number of assumptions and areas of disagreement will require further investigation. These include a discrepancy between the calculated and experimental thermal rate constants near zero pressure, a leveling off of the experimental rate constants that is not predicted by theory and which depends on the identity of the collider gas, the need to use rate constants for collision-induced IVR that are larger than the estimated total collision rate constants, and the choice of barrier-crossing frequency. Despite these unsettled issues, the theory of Leitner et al. shows great promise for accounting for possible non-RRKM effects in an important class of reactions.

  7. Outflow of Anthropogenic Semivolatile Organic Compounds From Asia and Trans-Pacific Transport to the Pacific Northwest of the U.S.A. in Spring 2004

    NASA Astrophysics Data System (ADS)

    Primbs, T.; Wilson, G.; Schmedding, D.; Higginbotham, C.; Simonich, S.

    2005-12-01

    China, compared to samples with trajectories associated with Japan. Preliminary results for Mt Bachelor showed elevated concentrations of PAHs, HCB, HCHs, and endosulfans in a sample collected on 25-26 April 2004 (trans-Pacific atmospheric transport event) as compared to a sample collected on 21-22 April 2004 (non-trans-Pacific atmospheric transport). Higher molecular weight PAHs were measured in the trans-Pacific event and not in the non-trans-Pacific event at Mt. Bachelor. The alpha to gamma HCH ratio has been used as an indicator of source region and it was very similar in most of the air masses sampled during the Okinawan air sampling campaign, with an average of 2.5 ± 1.0. The alpha to gamma HCH ratio in the trans-Pacific transport event at Mt Bachelor was 1.4 and 4.7 in the non-trans-Pacific event. In 2004, Shen et al. reported a N. American alpha to gamma ratio average of 3.6 and measurements closest to the Northwest of the U.S. in British Columbia had an average of 5.2. Additional samples from Mt Bachelor coupled with measurements from the Okinawan air sampling campaign will potentially further distinguish the differences in the trans-Pacific versus non-trans-Pacific atmospheric influences to Pacific Northwest.

  8. Epoxidation of alkenes through oxygen activation over a bifunctional CuO/Al2O3 catalyst.

    PubMed

    Scotti, Nicola; Ravasio, Nicoletta; Zaccheria, Federica; Psaro, Rinaldo; Evangelisti, Claudio

    2013-03-07

    The epoxidation of alkenes was carried out over a CuO/Al(2)O(3) catalyst using cumene as an oxygen carrier, through a one-pot reaction, giving high conversion and selectivity with different substrates. Trans-β-methylstyrene gave the corresponding epoxide in 95% yield after 3 h.

  9. New York City trans fat ban: improving the default option when purchasing foods prepared outside the home

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The adverse effects of trans fatty acid (trans fat) on cardiovascular health have been known for at least 2 decades. During that time, both the Dietary Guidelines for Americans and the Institute of Medicine’s Dietary Reference Intake guidelines have recommended restricting trans fat intake to the ex...

  10. Nutritional Profile of Phytococktail from Trans-Himalayan Plants

    PubMed Central

    Dhar, Priyanka; Tayade, Amol B.; Kumar, Jatinder; Chaurasia, Om P.; Srivastava, Ravi B.; Singh, Shashi B.

    2013-01-01

    We estimated the nutritive value, vitamin content, amino acid composition, fatty acid content, and mineral profile of a phytococktail comprising sea buckthorn (Hippophae rhamnoides), apricot (Prunus armeniaca), and roseroot (Rhodiola imbricata) from trans-Himalaya. The free vitamin forms in the phytococktail were determined by rapid resolution liquid chromatography/tandem mass spectrometry (RRLC-MS/MS). Vitamin E and B-complex vitamins were detected as the principle vitamins. Reversed-phase high performance liquid chromatography (RP-HPLC) with pre-column derivatization was used for identification and quantification of amino acids. Eight essential and eleven non-essential amino acids were quantified, and the content ranged between 76.33 and 9485.67 µg/g. Among the essential amino acids, L-methionine, L-phenylalanine, L-lysine, L-leucine, and L-histidine were found to be the dominant contributors. We also quantified the fatty acids in the phytococktail by using gas chromatography coupled with a flame ionization detector (GC-FID) with fatty acid methyl esters (FAMEs) derivatization. The analysis revealed the presence of 4 major fatty acids contributing to the total lipid content. Palmitic acid was found to be the rich source of saturated fatty acid (SFA) and constituted ∼31% of the total lipid content. Among the unsaturated fatty acids (UFAs), palmitoleic acid (43.47%), oleic acid (20.89%), and linoleic acid (4.31%) were prominent. The mineral profiling was carried out by inductively coupled plasma optical emission spectrometer (ICP-OES), and it was found to contain a number of important dietary mineral elements. The harsh climatic conditions, difficult terrain, and logistic constraints at high altitude regions of Indian trans-Himalayan cold desert lead to the scarcity of fresh fruits and vegetables. Therefore, the source of multiple vitamins, essential amino acids, fatty acids, and dietary minerals from the phytococktail would provide great health benefit in the

  11. Searching for trans ethyl methyl ether in Orion KL⋆

    NASA Astrophysics Data System (ADS)

    Tercero, B.; Cernicharo, J.; López, A.; Brouillet, N.; Kolesniková, L.; Motiyenko, R. A.; Margulès, L.; Alonso, J. L.; Guillemin, J.-C.

    2015-10-01

    We report on the tentative detection of trans ethyl methyl ether (tEME), t-CH3CH2OCH3, through the identification of a large number of rotational lines from each one of the spin states of the molecule towards Orion KL. We also search for gauche-trans-n-propanol, Gt-n-CH3CH2CH2OH, an isomer of tEME in the same source. We have identified lines of both species in the IRAM 30 m line survey and in the ALMA Science Verification data. We have obtained ALMA maps to establish the spatial distribution of these species. Whereas tEME mainly arises from the compact ridge component of Orion, Gt-n-propanol appears at the emission peak of ethanol (south hot core). The derived column densities of these species at the location of their emission peaks are ≤(4.0 ± 0.8) × 1015 cm-2 and ≤(1.0 ± 0.2) × 1015 cm-2 for tEME and Gt-n-propanol, respectively. The rotational temperature is ~100 K for both molecules. We also provide maps of CH3OCOH, CH3CH2OCOH, CH3OCH3, CH3OH, and CH3CH2OH to compare the distribution of these organic saturated O-bearing species containing methyl and ethyl groups in this region. Abundance ratios of related species and upper limits to the abundances of non-detected ethers are provided. We derive an abundance ratio N(CH3OCH3)/N(tEME) ≥ 150 in the compact ridge of Orion. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2011.0.00009.SV. ALMA is a partnership of ESO (representing its member states), NSF (USA), and NINS (Japan) with NRC (Canada), NSC, and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO, and NAOJ. This work was also based on observations carried out with the IRAM 30-m telescope. IRAM is supported by INSU/CNRS (France), MPG (Germany), and IGN (Spain).Appendix A is available in electronic form at http://www.aanda.org

  12. Extending the IEEE 802.15.4 Security Suite with a Compact Implementation of the NIST P-192/B-163 Elliptic Curves

    PubMed Central

    de la Piedra, Antonio; Braeken, An; Touhafi, Abdellah

    2013-01-01

    Typically, commercial sensor nodes are equipped with MCUsclocked at a low-frequency (i.e., within the 4–12 MHz range). Consequently, executing cryptographic algorithms in those MCUs generally requires a huge amount of time. In this respect, the required energy consumption can be higher than using a separate accelerator based on a Field-programmable Gate Array (FPGA) that is switched on when needed. In this manuscript, we present the design of a cryptographic accelerator suitable for an FPGA-based sensor node and compliant with the IEEE802.15.4 standard. All the embedded resources of the target platform (Xilinx Artix-7) have been maximized in order to provide a cost-effective solution. Moreover, we have added key negotiation capabilities to the IEEE 802.15.4 security suite based on Elliptic Curve Cryptography (ECC;. Our results suggest that tailored accelerators based on FPGA can behave better in terms of energy than contemporary software solutions for motes, such as the TinyECC and NanoECC libraries. In this regard, a point multiplication (PM) can be performed between 8.58- and 15.4-times faster, 3.40- to 23.59-times faster (Elliptic Curve Diffie-Hellman, ECDH) and between 5.45- and 34.26-times faster (Elliptic Curve Integrated Encryption Scheme, ECIES). Moreover, the energy consumption was also improved with a factor of 8.96 (PM). PMID:23899936

  13. Optimal Throughput and Self-adaptability of Robust Real-Time IEEE 802.15.4 MAC for AMI Mesh Network

    NASA Astrophysics Data System (ADS)

    Shabani, Hikma; Mohamud Ahmed, Musse; Khan, Sheroz; Hameed, Shahab Ahmed; Hadi Habaebi, Mohamed

    2013-12-01

    A smart grid refers to a modernization of the electricity system that brings intelligence, reliability, efficiency and optimality to the power grid. To provide an automated and widely distributed energy delivery, the smart grid will be branded by a two-way flow of electricity and information system between energy suppliers and their customers. Thus, the smart grid is a power grid that integrates data communication networks which provide the collected and analysed data at all levels in real time. Therefore, the performance of communication systems is so vital for the success of smart grid. Merit to the ZigBee/IEEE802.15.4std low cost, low power, low data rate, short range, simplicity and free licensed spectrum that makes wireless sensor networks (WSNs) the most suitable wireless technology for smart grid applications. Unfortunately, almost all ZigBee channels overlap with wireless local area network (WLAN) channels, resulting in severe performance degradation due to interference. In order to improve the performance of communication systems, this paper proposes an optimal throughput and self-adaptability of ZigBee/IEEE802.15.4std for smart grid.

  14. A WiSN node SoC with real-time image compressor and IEEE 802.15.4 MAC accelerator

    NASA Astrophysics Data System (ADS)

    Zhou, Renyan; Liu, Leibo; Yin, Shouyi; Luo, Ao; Chen, Xinkai; Wei, Shaojun

    2014-11-01

    This article presents a wireless image sensor node SoC (system-on-a-chip) for low-power wireless image sensor network (WiSN), in which camera chip interface, high-quality image compression and IEEE 802.15.4 compliant acceleration modules are integrated on chip. The proposed SoC contains a hardware-implemented real-time lossless JPEG (JPEG-LS) compression engine for Bayer Color Filter Arrays (Bayer CFA), reaching a 3.5 bits/pixel with peak signal to noise ratio (PSNR) greater than 46.3 dB and achieving a maximum 5 frames/s @16 MHz for VGA (640 × 480) colour images. The proposed hardware accelerator for IEEE 802.15.4 media access control (MAC) layer covers crucial protocol defined functions and algorithms, and reduces 45% software code in the host processor. This SoC has been fabricated in UMC 0.18 µm 1P6M CMOS process. The average power of the prototype chip is 18.2 mW at 3.0 V power supply and 16 MHz clock rate.

  15. Toward developing a unit of measure and scale of digital video quality: IEEE Broadcast Technology Society Subcomittee on Video Compression Measurements

    NASA Astrophysics Data System (ADS)

    Libert, John M.; Stanger, Leon; Watson, Andrew B.; Rohaly, Ann M.

    2000-06-01

    Development of video quality metrics has taken support from experimental vision data mainly at two levels of abstraction. On the one hand are the carefully controlled tests of human visual response to well-defined, controlled visual stimuli, such as the ModelFest study. On the other hand are experiments in which viewers rate the global quality of 'natural' video sequences exhibiting impairments of loosely-controlled composition and amplitude, as in the Video Quality Experts Group study. The IEEE Broadcast Technology Society Subcommittee on Video Compression Measurements has initiated an intermediate level approach to video quality assessment aimed toward developing a scale of video impairment and unit of measure by which to describe video distortion in both perceptual and engineering terms. The proposed IEEE study will attempt to define a scale of video impairment in terms of multiple measurements of the just-noticeable-difference (JND) of compression-induced video impairments. A paired comparison psychophysical method will be used to define a psychometric function of the visual sensitivity to compression-induced video impairments of various amplitudes. In this effort, quality assessment is related directly to visual perception of video impairments rather than to the more 'atomic' visual stimuli as used in many human vision experiments. Yet the experimenter's control over the stimuli is greater than that used in much of contemporary video quality testing.

  16. Extending the IEEE 802.15.4 security suite with a compact implementation of the NIST P-192/B-163 elliptic curves.

    PubMed

    de la Piedra, Antonio; Braeken, An; Touhafi, Abdellah

    2013-07-29

    Typically, commercial sensor nodes are equipped with MCUsclocked at a low-frequency (i.e., within the 4-12 MHz range). Consequently, executing cryptographic algorithms in those MCUs generally requires a huge amount of time. In this respect, the required energy consumption can be higher than using a separate accelerator based on a Field-programmable Gate Array (FPGA) that is switched on when needed. In this manuscript, we present the design of a cryptographic accelerator suitable for an FPGA-based sensor node and compliant with the IEEE802.15.4 standard. All the embedded resources of the target platform (Xilinx Artix-7) have been maximized in order to provide a cost-effective solution. Moreover, we have added key negotiation capabilities to the IEEE 802.15.4 security suite based on Elliptic Curve Cryptography (ECC). Our results suggest that tailored accelerators based on FPGA can behave better in terms of energy than contemporary software solutions for motes, such as the TinyECC and NanoECC libraries. In this regard, a point multiplication (PM) can be performed between 8.58- and 15.4-times faster, 3.40- to 23.59-times faster (Elliptic Curve Diffie-Hellman, ECDH) and between 5.45- and 34.26-times faster (Elliptic Curve Integrated Encryption Scheme, ECIES). Moreover, the energy consumption was also improved with a factor of 8.96 (PM).

  17. IEEE 802.15.4 MAC with GTS transmission for heterogeneous devices with application to wheelchair body-area sensor networks.

    PubMed

    Shrestha, Bharat; Hossain, Ekram; Camorlinga, Sergio

    2011-09-01

    In wireless personal area networks, such as wireless body-area sensor networks, stations or devices have different bandwidth requirements and, thus, create heterogeneous traffics. For such networks, the IEEE 802.15.4 medium access control (MAC) can be used in the beacon-enabled mode, which supports guaranteed time slot (GTS) allocation for time-critical data transmissions. This paper presents a general discrete-time Markov chain model for the IEEE 802.15.4-based networks taking into account the slotted carrier sense multiple access with collision avoidance and GTS transmission phenomena together in the heterogeneous traffic scenario and under nonsaturated condition. For this purpose, the standard GTS allocation scheme is modified. For each non-identical device, the Markov model is solved and the average service time and the service utilization factor are analyzed in the non-saturated mode. The analysis is validated by simulations using network simulator version 2.33. Also, the model is enhanced with a wireless propagation model and the performance of the MAC is evaluated in a wheelchair body-area sensor network scenario.

  18. Breaking down barriers: exploring the potential for social care practice with trans survivors of domestic abuse.

    PubMed

    Rogers, Michaela

    2016-01-01

    There is increasing recognition that domestic abuse takes place outside the heteronormative paradigm of social life. This paper presents a discussion of the findings of doctoral research which explores trans people's experiences of domestic abuse, their social care needs and whether these are met by domestic abuse agencies. This paper foregrounds debate on the intersections of domestic abuse, trans communities and social care provision as this research, and previous studies, suggests that trans survivors do not seek out or benefit from social care intervention. Qualitative data, collected via narrative interviews, were collected during 2012 from participants mainly located in the United Kingdom (two participants were based in the United States). A total of 24 interviews were undertaken with trans people (n = 15) and social care practitioners (n = 9). Data were examined using a voice-centred relational technique. The findings reveal that barriers are multiple and complex but work could be undertaken to encourage help-seeking behaviours. Barriers include expectations of a transphobic response and 'Othering' practices; lack of entitlement felt by trans people; lack of knowledge/misunderstandings about trans social care needs; heteronormative bias of existing services; and practitioner attitudes fixed to notions about gender as binary. The paper ends by proposing a framework for practice with trans survivors which incorporates a person-centred, narrative approach.

  19. Suicide risk in trans populations: An application of minority stress theory.

    PubMed

    Tebbe, Elliot A; Moradi, Bonnie

    2016-10-01

    Drawing on minority stress theory, the present study tested the relations of minority stressors (i.e., experiences of prejudice and discrimination, internalized antitrans attitudes, fear of antitrans stigma), social support (i.e., friend, family, and significant other support), and substance use (i.e., drug and alcohol use) with depression and suicide risk in a sample of trans individuals. Depression was examined as a mediator of the relations of minority stressors and social support with suicide risk; drug and alcohol use were examined as direct correlates of suicide risk. Participants were 335 trans-identified individuals, diverse in gender identities (e.g., trans men, trans women, nonbinary gender identities). They were recruited using online social networks and they completed the study survey online via Qualtrics. Structural equation modeling was used to test hypothesized relations. Depression fully mediated the relations of perceived experiences of discrimination, fear of antitrans stigma, and friend support with suicide risk, and partially mediated the relation of internalized antitrans attitudes with suicide. Drug use was positively associated with suicide risk, whereas alcohol use was not linked with suicide risk. Exploratory comparisons across gender subgroups suggested that the pattern of relations among study variables was consistent across trans men, trans women, and individuals with nonbinary gender identities. These findings point to minority stressors, friend support, and drug use as potentially fruitful targets of prevention and intervention efforts to reduce depression and suicide risk in trans populations. (PsycINFO Database Record

  20. Can trans-generational experiments be used to enhance species resilience to ocean warming and acidification?

    PubMed

    Chakravarti, Leela J; Jarrold, Michael D; Gibbin, Emma M; Christen, Felix; Massamba-N'Siala, Gloria; Blier, Pierre U; Calosi, Piero

    2016-10-01

    Human-assisted, trans-generational exposure to ocean warming and acidification has been proposed as a conservation and/or restoration tool to produce resilient offspring. To improve our understanding of the need for and the efficacy of this approach, we characterized life-history and physiological responses in offspring of the marine polychaete Ophryotrocha labronica exposed to predicted ocean warming (OW: + 3°C), ocean acidification (OA: pH -0.5) and their combination (OWA: + 3°C, pH -0.5), following the exposure of their parents to either control conditions (within-generational exposure) or the same conditions (trans-generational exposure). Trans-generational exposure to OW fully alleviated the negative effects of within-generational exposure to OW on fecundity and egg volume and was accompanied by increased metabolic activity. While within-generational exposure to OA reduced juvenile growth rates and egg volume, trans-generational exposure alleviated the former but could not restore the latter. Surprisingly, exposure to OWA had no negative impacts within- or trans-generationally. Our results highlight the potential for trans-generational laboratory experiments in producing offspring that are resilient to OW and OA. However, trans-generational exposure does not always appear to improve traits and therefore may not be a universally useful tool for all species in the face of global change.

  1. Photochemical charge transfer excitation of trans-4-stilbazole at a silver electrode

    NASA Astrophysics Data System (ADS)

    McMahon, John J.; Gergel, Thomas J.; Otterson, David M.; McMahon, Caitlin R.; Kabbani, Raifah M.

    1999-10-01

    When adsorbed at the surface of a polycrystalline silver electrode, trans-4-stilbazole photoreacts, in the presence of dissolved oxygen, to form trans-4'-hydroxy-4-stilbazole. The structure of the photoproduct is confirmed by (1) a comparison of the surface Raman results with the normal Raman of trans-4'-hydroxy-4-stilbazole, and by (2) by ex-situ analysis of the irradiated electrode surface using high-resolution mass spectrometry. The surface photochemistry appears to be a one-photon process whose threshold wavelength lies in the middle of the visible range though neat trans-4-stilbazole absorbs only in the ultraviolet. The surface Raman intensity of the photoproduct increases synchronously with the Faradaic current of oxygen reduction. Attendant incorporation of oxygen exclusively at the 4' position of end-on trans-4-stilbazole evidences a photo-initiated electron transfer from the electrode to oxygen reducing at the other end of the molecule. Scattering from stilbazole adsorbed at two different surface sites is evident in the surface Raman spectrum: charged (Ag +) sites and more neutral surface sites. We assign excitation profile maxima for stilbazole at Ag + sites and the photochemical initiation to a silver-to-stilbazole charge transfer at those sites. Ab-initio molecular orbital calculations on a model composed of a ground state Li 0- trans-4-stilbazole and the anion radical excited state Li +- trans-4-stilbazole - reveal a low-energy transition that supports assignment of the visible excitation to a silver-to-stilbazole electron transfer.

  2. Trans-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model

    PubMed Central

    Kimura, Yuka; Suzuki, Sachina; Tatefuji, Tomoki; Umegaki, Keizo

    2016-01-01

    Aim: Resveratrol is a popular ingredient in dietary supplements. Some patients concomitantly use dietary supplements and medicines in Japan. In the present study, we determined whether trans-resveratrol and melinjo (Gnetum gnemon L.) seed extract (MSE), which contains resveratrol dimers, interacted with drugs using a mouse model. Methods: Male C57BL/6J mice were fed experimental diets containing 0.005%, 0.05%, or 0.5% (w/w) trans-resveratrol or MSE for 1 or 12 weeks. The expression of liver cytochrome P-450 (CYP) mRNA and activity of liver microsomal CYP were measured. To determine the influence of resveratrol or MSE on drug efficacy, the anticoagulant activity of warfarin was examined in mice that were fed diets containing trans-resveratrol or MSE for 12 weeks. Results: When the mice were fed experimental diets for 1 week, none of the doses of trans-resveratrol and MSE affected body weight, liver weight, or plasma AST and ALT levels. Trans-resveratrol also did not affect CYP1A1, CYP1A2, CYP2C, or CYP3A activities. In contrast, 0.5% MSE slightly increased CYP1A1 activity. When the mice were fed experimental diets for 12 weeks, 0.05% trans-resveratrol increased CYP1A1, CYP2C, and CYP3A activities, whereas 0.5% MSE suppressed CYP3A activity. Under these conditions, 0.5% trans-resveratrol enhanced the anticoagulant activity of warfarin, although CYP2C activity increased. However, MSE did not affect the anticoagulant activity of warfarin. Conclusion: The 0.05% trans-resveratrol did not interact with warfarin in a mouse model, whereas 0.5% trans-resveratrol may have enhanced the anticoagulant activity of warfarin. PMID:26947597

  3. DNA adducts of antitumor trans-[PtCl2 (E-imino ether)2].

    PubMed Central

    Brabec, V; Vrána, O; Nováková, O; Kleinwächter, V; Intini, F P; Coluccia, M; Natile, G

    1996-01-01

    It has been shown recently that some analogues of clinically ineffective trans-diamminedichloroplatinum (II) (transplatin) exhibit antitumor activity. This finding has inverted the empirical structure-antitumor activity relationships delineated for platinum(II) complexes, according to which only the cis geometry of leaving ligands in the bifunctional platinum complexes is therapeutically active. As a result, interactions of trans platinum compounds with DNA, which is the main pharmacological target of platinum anticancer drugs, are of great interest. The present paper describes the DNA binding of antitumor trans-[PtCl(2)(E-imino ether)(2)] complex (trans-EE) in a cell-free medium, which has been investigated using three experimental approaches. They involve thiourea as a probe of monofunctional DNA adducts of platinum (II) complexes with two leaving ligands in the trans configuration, ethidium bromide as a probe for distinguishing between monofunctional and bifunctional DNA adducts of platinum complexes and HPLC analysis of the platinated DNA enzymatically digested to nucleosides. The results show that bifunctional trans-EE preferentially forms monofunctional adducts at guanine residues in double-helical DNA even when DNA is incubated with the platinum complex for a relatively long time (48 h at 37 degrees C in 10 mM NaCIO(4). It implies that antitumor trans-EE modifies DNA in a different way than clinically ineffective transplatin, which forms prevalent amount of bifunctional DNA adducts after 48 h. This result has been interpreted to mean that the major adduct of trans-EE, occurring in DNA even after long reaction times, is a monofunctional adduct in which the reactivity of the second leaving group is markedly reduced. It has been suggested that the different properties of the adducts formed on DNA by transplatin and trans-EE are relevant to their distinct clinical efficacy. PMID:8628659

  4. Ruminant and industrial trans-fatty acid uptake in the heart.

    PubMed

    Ganguly, Riya; LaVallee, Renee; Maddaford, Thane G; Devaney, Brittany; Bassett, Chantal M C; Edel, Andrea L; Pierce, Grant N

    2016-05-01

    Dietary trans-fats are strongly associated with heart disease. However, the capacity for the tissues of the body, and specifically the heart, to take up trans-fats is unknown. It is also unknown if different trans-fats have different uptake capacities in the heart and other tissues of the body. Diets of low-density lipoprotein receptor-deficient mice were supplemented for 14weeks with foods that contained 1.5% of the trans-fat elaidic acid or vaccenic acid. Tissues were extracted and frozen in liquid nitrogen, and then lipids were analyzed by gas chromatography for fatty acid content. Isolated cardiomyocytes were also exposed to elaidic or vaccenic acid in cell culture media for 24h. Dietary supplementation with vaccenic or elaidic acid resulted in a 20-fold higher accumulation of these TFAs in fat deposits in the body in comparison to liver. Liver tissue accumulated about twice as much per gram tissue as heart. Similar quantities of both elaidic acid and vaccenic acid were taken up by the tissues. Isolated cardiomyocytes exhibited an unusually large uptake of trans-fat, and this was dependent upon both the concentration and duration of exposure to the trans-fats but not upon the type of trans-fat. Expression levels of CD36 and FATP4 were not significantly changed during dietary interventions or exposure of cells to trans-fats. We conclude that fat, liver and heart (including cardiomyocytes) are all capable of accumulating trans-fat in response to dietary supplementation without changes in fatty acid transport protein expression.

  5. Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

    PubMed Central

    Iwata, Naomi G.; Pham, Matilda; Rizzo, Norma O.; Cheng, Andrew M.; Maloney, Ezekiel; Kim, Francis

    2011-01-01

    Intake of trans fatty acids (TFA), which are consumed by eating foods made from partially hydrogenated vegetable oils, is associated with a higher risk of cardiovascular disease. This relation can be explained by many factors including TFA's negative effect on endothelial function and reduced nitric oxide (NO) bioavailability. In this study we investigated the effects of three different TFA (2 common isomers of C18 found in partially hydrogenated vegetable oil and a C18 isomer found from ruminant-derived—dairy products and meat) on endothelial NF-κB activation and nitric oxide (NO) production. Human endothelial cells were treated with increasing concentrations of Elaidic (trans-C18:1 (9 trans)), Linoelaidic (trans-C18:2 (9 trans, 12 trans)), and Transvaccenic (trans-C18:1 (11 trans)) for 3 h. Both Elaidic and Linoelaidic acids were associated with increasing NF-κB activation as measured by IL-6 levels and phosphorylation of IκBα, and impairment of endothelial insulin signaling and NO production, whereas Transvaccenic acid was not associated with these responses. We also measured superoxide production, which has been hypothesized to be necessary in fatty acid-dependent activation of NF-κB. Both Elaidic acid and Linoelaidic acid are associated with increased superoxide production, whereas Transvaccenic acid (which did not induce inflammatory responses) did not increase superoxide production. We observed differential activation of endothelial superoxide production, NF-κB activation, and reduction in NO production by different C18 isomers suggesting that the location and number of trans double bonds effect endothelial NF-κB activation. PMID:22216328

  6. Assembly and disassembly of the Golgi complex: two processes arranged in a cis-trans direction

    PubMed Central

    1992-01-01

    We have studied the disassembly and assembly of two morphologically and functionally distinct parts of the Golgi complex, the cis/middle and trans cisterna/trans network compartments. For this purpose we have followed the redistribution of three cis/middle- (GMPc-1, GMPc-2, MG 160) and two trans- (GMPt-1 and GMPt-2) Golgi membrane proteins during and after treatment of normal rat kidney (NRK) cells with brefeldin A (BFA). BFA induced complete disassembly of the cis/middle- and trans- Golgi complex and translocation of GMPc and GMPt to the ER. Cells treated for short times (3 min) with BFA showed extensive disorganization of both cis/middle- and trans-Golgi complexes. However, complete disorganization of the trans part required much longer incubations with the drug. Upon removal of BFA the Golgi complex was reassembled by a process consisting of three steps: (a) exist of cis/middle proteins from the ER and their accumulation into vesicular structures scattered throughout the cytoplasm; (b) gradual relocation and accumulation of the trans proteins in the vesicles containing the cis/middle proteins; and (c) assembly of the cisternae, and reconstruction of the Golgi complex within an area located in the vicinity of the centrosome from which the ER was excluded. Reconstruction of the cis/middle-Golgi complex occurred under temperature conditions inhibitory of the reorganization of the trans- Golgi complex, and was dependent on microtubules. Reconstruction of the trans-Golgi complex, disrupted with nocodazole after selective fusion of the cis/middle-Golgi complex with the ER, occurred after the release of cis/middle-Golgi proteins from the ER and the assembly of the cis/middle cisternae. PMID:1730750

  7. Temperature dependence of the lowest excited singlet-state lifetime of all- trans -. beta. -carotene and fully deuterated all- trans -. beta. -carotene

    SciTech Connect

    Wasielewski, M.R.; Johnson, D.G. ); Bradford, E.G.; Kispert, L.D. )

    1989-12-01

    A 4 ps, 450 nm laser pulse was used to electronically excite all-{ital trans}-{beta}-carotene and all-{ital trans}-{beta}-carotene-{ital d}{sub 56} in 3-methylpentane. The transient absorption spectra of these molecules were measured as a function of temperature down to 20 K. In all cases the 400--500 nm electronic absorption band of each carotene bleaches and a new absorption band near 560 nm appears immediately upon excitation. These bands recover with single exponential kinetics: {tau}=8.1{plus minus}0.5 ps for all-{ital trans}-{beta}-carotene, and {tau}=10.5{plus minus}0.6 ps for all-{ital trans}-{beta}-carotene-{ital d}{sub 56} at 294 K. These recovery times increase by about a factor of 2 in glassy 3-methylpentane, and are nearly independent of temperature from 100 to 20 K. The weak dependencies of the lowest excited single-state lifetime of all-{ital trans}-{beta}-carotene on deuteration and temperature are discussed in terms of nonradiative decay mechanisms within carotenoids.

  8. ELEVATED TRANS-MAMMARY TRANSMISSION OF Toxocara canis LARVAE IN BALB/c MICE

    PubMed Central

    Telmo, Paula de Lima; de Avila, Luciana Farias da Costa; dos Santos, Cristina Araújo; de Aguiar, Patrícia de Souza; Martins, Lourdes Helena Rodrigues; Berne, Maria Elisabeth Aires; Scaini, Carlos James

    2015-01-01

    Toxocariasis is a widespread zoonosis and is considered an important worldwide public health problem. The aim of this study was to investigate the frequency of trans-mammary Toxocara canis infection in newborn BALB/c mice nursed by females experimentally infected with 1,200 eggs after delivery. After 50 days of age, the presence of larvae in different organs of the offspring was investigated. Trans-mammary infection was confirmed in 73.9% of the mice that had been nursed by infected females. These data show a high trans-mammary transmission of T. canis and confirm the significance of this transmission route in paratenic hosts. PMID:25651332

  9. World-wide consumption of trans fatty acids.

    PubMed

    Craig-Schmidt, Margaret C

    2006-05-01

    Dietary trans fatty acids (TFA) originate from commercially hydrogenated oils and from dairy and meat fats. Estimates of dietary TFA consumption vary with dietary habits and food supply as well as methods used to estimate consumption. Methods include: (1) market share data, (2) laboratory analysis of duplicate portions or composite diets, (3) analysis of consumption data of a representative population, and (4) biomarkers, such as human milk. In North America, daily intakes have been estimated by food frequency questionnaire to be 3-4 g/person and by extrapolation of human milk data to be greater than 10 g/person. Diets in northern Europe traditionally have contained more TFA than in Mediterranean countries where olive oil is used. Intakes in Europe range from minimal values in Italy, Portugal, Greece and Spain (1.4-2.1 g/day) to greater values for Germany, Finland, Denmark, Sweden, France, United Kingdom, Belgium, Norway, The Netherlands, and Iceland (2.1-5.4 g/day) Recent decreases in dietary TFA have been observed due to modifications of commercial fats and changes in consumer choices. The impact of legislation restricting use of hydrogenated fats and requiring TFA content on food labels awaits future studies.

  10. PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space.

    PubMed

    Lopes, Carla A M; Jana, Swadhin Chandra; Cunha-Ferreira, Inês; Zitouni, Sihem; Bento, Inês; Duarte, Paulo; Gilberto, Samuel; Freixo, Francisco; Guerrero, Adán; Francia, Maria; Lince-Faria, Mariana; Carneiro, Jorge; Bettencourt-Dias, Mónica

    2015-10-26

    Centrioles are essential for cilia and centrosome assembly. In centriole-containing cells, centrioles always form juxtaposed to pre-existing ones, motivating a century-old debate on centriole biogenesis control. Here, we show that trans-autoactivation of Polo-like kinase 4 (PLK4), the trigger of centriole biogenesis, is a critical event in the spatial control of that process. We demonstrate that centrioles promote PLK4 activation through its recruitment and local accumulation. Though centriole removal reduces the proportion of active PLK4, this is rescued by concentrating PLK4 to the peroxisome lumen. Moreover, while mild overexpression of PLK4 only triggers centriole amplification at the existing centriole, higher PLK4 levels trigger both centriolar and cytoplasmatic (de novo) biogenesis. Hence, centrioles promote their assembly locally and disfavor de novo synthesis. Similar mechanisms enforcing the local concentration and/or activity of other centriole components are likely to contribute to the spatial control of centriole biogenesis under physiological conditions.

  11. Electronic coherence dynamics in trans-polyacetylene oligomers.

    PubMed

    Franco, Ignacio; Brumer, Paul

    2012-04-14

    Electronic coherence dynamics in trans-polyacetylene oligomers are considered by explicitly computing the time dependent molecular polarization from the coupled dynamics of electronic and vibrational degrees of freedom in a mean-field mixed quantum-classical approximation. The oligomers are described by the Su-Schrieffer-Heeger Hamiltonian and the effect of decoherence is incorporated by propagating an ensemble of quantum-classical trajectories with initial conditions obtained by sampling the Wigner distribution of the nuclear degrees of freedom. The electronic coherence of superpositions between the ground and excited and between pairs of excited states is examined for chains of different length, and the dynamics is discussed in terms of the nuclear overlap function that appears in the off-diagonal elements of the electronic reduced density matrix. For long oligomers the loss of coherence occurs in tens of femtoseconds. This time scale is determined by the decay of population into other electronic states through vibronic interactions, and is relatively insensitive to the type and class of superposition considered. By contrast, for smaller oligomers the decoherence time scale depends strongly on the initially selected superposition, with superpositions that can decay as fast as 50 fs and as slow as 250 fs. The long-lived superpositions are such that little population is transferred to other electronic states and for which the vibronic dynamics is relatively harmonic.

  12. Permeability controls in the Santana Tuff, Trans-Pecos Texas

    SciTech Connect

    Smyth, R.C.; Sharp, J.M. Jr. . Dept. of Geological Sciences)

    1993-02-01

    The Santana Tuff is a poorly to densely welded rhyolitic ash-flow tuff that erupted from the Sierra Rica caldera complex in Chihuahua, Mexico, 27.8 m.y. ago. The portion of the Santana Tuff examined in this study crops out over a 125-km[sup 2] area in the Big Bend Ranch State Natural Area in Trans-Pecos Texas. A review of recent literature has revealed the need to incorporate realistic values for permeability due to fracture spacing into groundwater models. Permeability/porosity relationship for fracture skins and unaltered tuff are significant to problems of solute transport. Permeability measurements of tuff samples vary over four orders of magnitude. The most densely welded samples have the lowest permeability. The least densely welded ones have the highest permeability. However, effective permeabilities of the differentially welded layers are quite different if fractures are considered. The spacing of cooling fractures in poorly to densely welded layers of the Santana Tuff also varies considerably. Degree of welding of the different Santana Tuff units has been quantified by length-to-width ratios (flattening) of pumice fragments. Lognormally distributed fracture spacing measurements correlate directly with the degree of welding. Rose diagrams and stereonets indicate that fracture orientations are not always random, as might be inferred from a cooling origin, but may have preferred orientation patterns.

  13. Characterization of trans-neuronal trafficking of Cbln1.

    PubMed

    Wei, Peng; Rong, Yongqi; Li, Leyi; Bao, Dashi; Morgan, James I

    2009-06-01

    Cbln1, a glycoprotein secreted from granule cells and GluRdelta2 in the postsynaptic densities of Purkinje cells are components of an incompletely understood pathway essential for integrity and plasticity of parallel fiber-Purkinje cell synapses. We show that Cbln1 undergoes anterograde transport from granule cells to Purkinje cells and Bergmann glia, and enters the endolysosomal trafficking system, raising the possibility that Cbln1 exerts its activity on or within Purkinje cells and Bergmann glia. Cbln1 is absent in Purkinje cells and Bergmann glia of GluRdelta2-null mice, suggesting a mechanistic convergence on Cbln1 trafficking. Ectopic expression of Cbln1 in Purkinje cells of L7-cbln1 transgenic mice reveals Cbln1 undergoes anterograde and retrograde trans-neuronal trafficking even across synapses that lack GluRDelta2, indicating that it is not universally essential for Cbln1 transport. The L7-cbln1 transgene also ameliorates the locomotor deficits of cbln1-null mice, indicating that the presence and/or release of Cbln1 from the postsynaptic neuron has functional consequences.

  14. The Trans-Pacific Partnership and pharmaceutical innovation.

    PubMed

    Freeman, Robert A

    2016-01-01

    Trade agreements are an overlooked area of research and policy analysis that affect market access, pricing and reimbursement decisions by pharmaceutical manufacturers, and research and development decisions in the long term. The Trans-Pacific Partnership (TPP) is the most recent multi-national agreement under considerations that may have profound implications in developed and developing countries in the Pacific Rim. As in the case of other trade arrangements, the TPP negotiations are not transparent, but a major leak of the most recent draft has been published in WikiLeaks. The leaked document has raised a number of concerns about intellectual property rights (IPR) and regulatory data protection (RDP) that have implications for public health and economic policy throughout the region. In particular, IPR and RDP go beyond the minimum standards set under the World Trade Organization (WTO) and may affect drug access negatively by delaying generic drug and biosimilar product availability and by raising prices by removing national regulations dealing with drug pricing and reimbursement. Of particular concern is the establishment of a litigation process where multi-national companies can sue individual countries before a panel of private attorneys who are appointed by the World Bank or United Nations. This paper addresses these concerns along with a commentary on the likelihood of occurring and the need for future research.

  15. Isla Hispaniola: A trans-boundary flood risk mitigation plan

    NASA Astrophysics Data System (ADS)

    Brandimarte, Luigia; Brath, Armando; Castellarin, Attilio; Baldassarre, Giuliano Di

    It is sadly known that over the past decades Isla Hispaniola (Haiti and the Dominican Republic) has been exposed to the devastating passage of several hurricanes and tropical storms. Territories that are economically weak and extremely poor in terms of natural resources have been shaken by severe flood events that caused the loss of thousands of human lives, displacement of people and damage to the environment. On May 24th 2004, the flooding of the trans-boundary river Soliette killed over 1000 Haitian and Dominican people, wiping out villages and leaving behind desolation and poverty. After this catastrophic flood event, the General Direction for Development and Cooperation of the Italian Department of Foreign Affairs funded through the Istituto Italo-Latino Americano (IILA, www.iila.org) an international cooperation initiative (ICI), coordinated and directed by the University of Bologna. The ICI involved Haitian and Dominican institutions and was twofold: (a) institutional capacity building on flood risk management and mitigation measures and policies; (b) hydrological and hydraulic analysis of the May 2004 flood event aimed at formulating a suitable and affordable flood risk mitigation plan, consisting of structural and non-structural measures.

  16. Technological approaches to minimize industrial trans fatty acids in foods.

    PubMed

    Menaa, Farid; Menaa, Abder; Tréton, Jacques; Menaa, Bouzid

    2013-03-01

    Trans fatty acids (TFAs) mainly arise from 2 major sources: natural ruminal hydrogenation and industrial partial catalytic hydrogenation. Increasing evidence suggests that most TFAs and their isomers cause harmful health effects (that is, increased risk of cardiovascular diseases). Nevertheless, in spite of the existence of an international policy consensus regarding the need for public health action, several countries (for example, France) do not adopt sufficient voluntary approaches (for example, governmental regulations and systematic consumer rejections) nor sufficient industrial strategies (for example, development of healthier manufacturing practices and innovative processes such as fat interesterifications) to eliminate deleterious TFAs from processed foods while ensuring the overall quality of the final product (for example, nutritional value and stability). In this manuscript, we first review the physical-chemical properties of TFAs, their occurrence in processed foods, their main effects on health, and the routine analytical methods to characterize TFAs, before emphasizing on the major industrial methods (that is, fat food reformulation, fat interesterification, genetically modified FAs composition) that can be used worldwide to reduce TFAs in foods.

  17. Stellar Occultations by Trans-Neptunian Objects and Centaurs

    NASA Astrophysics Data System (ADS)

    Wolf, Juergen

    2015-10-01

    Our solar system beyond Neptune's orbit is populated with numerous small objects, referred to as Trans-Neptunian Objects (TNOs). About 1400 TNOs are known today ranging in size from the most prominent one, Pluto (2370 km diameter), down to a few tens of kilometers. Most diameters have been determined by radiometric methods in the IR/FIR (SPITZER, HERSCHEL) with uncertainties in the 20% range. Only for Pluto and about 12 other objects have the projected diameters been measured more accurately by stellar occultations. A group of objects lingering between the orbits of Jupiter and Neptune, the Centaurs, are believed to have originated from TNOs. Two of them, Chariklo and Chiron, have recently drawn attention, as stellar occultations have revealed rings around them. Our proposed occultation observations with SOFIA shall add to the sparse knowledge on TNOs and Centaurs by determining more projected diameters and albedos. They have the potential of detecting moons, rings and atmospheres. We will use SOFIA's demonstrated capability of measuring occultations (Pluto 2011 & 2015) with its Focal Plane Imager (FPI) to observe up to five events on flight legs of approximately 30 min each. As most of these events cannot be predicted accurately enough more than a few months or weeks ahead of time, we propose these as targets of opportunity.

  18. Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs

    PubMed Central

    Soares, Deivid Costa; Saraiva, Elvira Maria

    2015-01-01

    Background Stilbene-based compounds show antitumoral, antioxidant, antihistaminic, anti-inflammatory and antimicrobial activities. Here, we evaluated the effect of the trans-resveratrol analogs, pterostilbene, piceatannol, polydatin and oxyresveratrol, against Leishmania amazonensis. Methodology/Principal Findings Our results demonstrated a low murine macrophage cytotoxicity of all four analogs. Moreover, pterostilbene, piceatannol, polydatin and oxyresveratrol showed an anti-L. amazonensis activity with IC50 values of 18 μM, 65 μM, 95 μM and 65 μM for promastigotes, respectively. For intracellular amastigotes, the IC50 values of the analogs were 33.2 μM, 45 μM, 29 μM and 30.5 μM, respectively. Among the analogs assayed only piceatannol altered the cell cycle of the parasite, increasing 5-fold the cells in the Sub-G0 phase and decreasing 1.7-fold the cells in the G0-G1 phase. Piceatannol also changed the parasite mitochondrial membrane potential (ΔΨm) and increased the number of annexin-V positive promastigotes, which suggests incidental death. Conclusion/Significance Among the analogs tested, piceatannol, which is a metabolite of resveratrol, was the more promising candidate for future studies regarding treatment of leishmaniasis. PMID:26517558

  19. Trans-ungual delivery of itraconazole hydrochloride by iontophoresis.

    PubMed

    Kushwaha, Avadhesh; Jacob, Melissa; Shiva Kumar, H N; Hiremath, Shobharani; Aradhya, Sacchidanand; Repka, Michael A; Murthy, S Narasimha

    2015-01-01

    Itraconazole (ITR) is a potent antifungal drug. However, poor aqueous solubility limits its permeation ability across the human nail plate. Therefore, in this project, ITR was converted to hydrochloride salt (ITR-HCl) to improve its solubility and to render it amenable to iontophoresis. ITR-HCl was characterized by spectroscopic methods and antifungal efficacy was evaluated in comparison to the base. In vitro and ex vivo transport studies (passive and iontophoresis) were carried out across the porcine hoof membrane and excised human cadaver toe using two different protocols; continuous delivery of drug for 24 h and pulsed delivery of drug for 3 days (8 h/day). The antifungal efficacy of ITR-HCL was comparable to ITR. Iontophoresis was found to be more effective than passive mode of delivery of ITR-HCL. In both iontophoresis as well as passive mode of delivery, the pulsed protocol resulted in more ungual and trans-ungual delivery of drug than continuous protocol. ITR-HCL could be delivered into and across the nail plate by iontophoresis. Human cadaver toe appears to be a good model to investigate the ungual delivery of drugs.

  20. Trans-dimensional ambient noise tomography of the northeast Asia

    NASA Astrophysics Data System (ADS)

    Kim, Seongryong; Tkalčić, Hrvoje; Rhie, Junkee; Chen, Youlin

    2016-04-01

    A trans-dimensional and hierarchical Bayesian tomography is performed to estimate spatial variations of shear wave velocity and provide the uncertainty in the northeast Asia region from the ambient noise data. The method accounts for irregular data distribution and sensitivity using adaptive partition property of Voronoi cells. Importantly, the number of basis functions used to parameterise the Earth model in the inversion and the level of data noise are implicitly balanced by the information contained in the data (and treated as free parameters in the inversions). Thereby more reliable models and their rigorous uncertainties are estimated by avoiding over- or under-estimation and explicit regularisation. We measure Rayleigh wave phase and group velocity (8-70 s) for available inter-station paths between more than 300 broadband stations. The obtained group and phase velocity maps reveal characteristic features beneath the former (East Sea also known as Japan Sea) and the current back-arc (Okinawa trough) regions, where relatively high and low velocities are estimated at intermediate (20-40 s) and longer periods (50-60 s), respectively. We observe that the low velocity anomalies extend to beneath intraplate volcanoes in the northeast China and the Korean Peninsula. Based on the depth sensitivity of surface wave dispersions and previous geological evidences, we argue that the intraplate volcanism in this region might be influenced by sub-lithospheric processes related to the subduction of the Pacific and Philippine Sea plates.