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Sample records for ala american library

  1. Research on the History of the American Library Association.

    ERIC Educational Resources Information Center

    Thomison, Dennis

    A researcher on the history of the American Library Association (ALA) describes problems encountered on his project, important trends in ALA, weaknesses and benefits of ALA, and needs in the area of historical research. Some of the problems cited are the inadequacy of organization and housing of the ALA archives, the unevenness of the archival…

  2. Books for Gerstner Field Aviators: The Mexican Border Traveling Library Service and ALA in Southwest Louisiana during World War I.

    ERIC Educational Resources Information Center

    Bordelon, Kathie

    This paper examines the efforts made by the American Library Association (ALA) and the Mexican Border Traveling Library Service (MBTLS) to ensure that remote World War I outposts, such as the Gerstner Field aviation and military training camp in Louisiana, would have adequate library service. A history of the MBTLS' early organizational success,…

  3. ALA Candidates: Presidential Timbre

    ERIC Educational Resources Information Center

    Berry, John N., III

    2010-01-01

    This article presents an interview with two effective spokespeople, notable school librarian Sara Kelly Johns and retired public library administrator Molly Raphael, who compete to be American Library Association (ALA) president. One of them will be elected president of ALA for a year's term beginning in July 2011. Each candidate comes from a…

  4. The American Library Association in Latin America: American Librarianship as a "Modern" Model during the Good Neighbor Policy Era.

    ERIC Educational Resources Information Center

    Maymi-Sugranes, Hector J.

    2002-01-01

    Through American Library Association (ALA) projects in Latin America, American librarianship progressed from conceptualization to implementation as the model in modernizing Latin American library practices and societies. Development of library practices was fundamental to pursuit of a "modern" society. In fighting fascist propaganda, the United…

  5. Rocks in the Whirlpool: Equity of Access and the American Library Association.

    ERIC Educational Resources Information Center

    McCook, Kathleen de la Pena

    This paper provides some of the historical context of the efforts of the American Library Association (ALA) to define, extend, protect and advocate for equity of access, focusing on central tendencies rather than internal debate. The first section, "Toward the Concept of Access," discusses: how ALA became a public service organization; extension…

  6. The African American Male Librarian: Motivational Factors in Choosing a Career in Library and Information Science

    ERIC Educational Resources Information Center

    Davis-Kendrick, Kaetrena D.

    2009-01-01

    A recent American Library Association (ALA) report has shown that less than 1% of credentialed librarians are African American males. This article discusses possible reasons for this dearth; and, in an effort to inform future LIS recruiting and marketing campaigns, the included study attempted to discover which factors lead African American males…

  7. The Development of the Partnership between the American Library Association and the National Council for Accreditation of Teacher Education

    ERIC Educational Resources Information Center

    Gann, Linda A.

    2010-01-01

    This qualitative study examined the development of the partnership between the American Library Association (ALA) and the National Council for Accreditation of Teacher Education (NCATE). The research focused on archival documents from the ALA Archives at the University of Illinois Archives. The archival research focused on documents during the…

  8. ALA 2010: The Costly Cornucopia

    ERIC Educational Resources Information Center

    Berry, John N., III

    2010-01-01

    Every librarian wants to go to the American Library Association (ALA) annual conference in Washington, DC, June 24-29. Despite that, more than half of those asked informally said they can't afford it. The good news is a cornucopia of programs aimed at nearly every need of librarians of all types and including every best practice in libraries. Many…

  9. Bachelor's Degree in Library and Information Science Field: A Comparative Analysis Study Performed on Distinguished American Universities

    ERIC Educational Resources Information Center

    Abouserie, Hossam Eldin Mohamed Refaat

    2009-01-01

    This study explored the state of bachelor's degree offered at top Library and Information Science schools in the United States in 2009. Schools selected were accredited on the Master's level and ranked as top five Library and Information Science schools by the American Library Association, ALA. The study embraced the comparative analysis…

  10. A Fifty-Five Year Partnership: ALA and the AFL-CIO.

    ERIC Educational Resources Information Center

    Meyers, Arthur S.

    2002-01-01

    Provides a history of the establishment of the AFL-CIO/ALA (American Federation of Labor (AFL)-Congress of Industrial Organizations (CIO)/American Library Association (ALA)) Joint Committee on Library Service to Labor Groups. Topics include public learning, labor, and libraries; services to labor; problems and issues, including conflicts between…

  11. ALA Midwinter 2011 Preview: A Better Place

    ERIC Educational Resources Information Center

    Berry, John N., III

    2010-01-01

    There has been an effort to make the American Library Association (ALA) Midwinter Meeting "member-friendly," so that more ALA members will attend. Held January 7-11 in beautiful San Diego, the conference program is loaded with interesting events that look suspiciously like entertainment, plus learning opportunities, and the usual parties and…

  12. Homecoming for Library Symbol.

    ERIC Educational Resources Information Center

    Egan, Bessie

    1987-01-01

    Discusses the significance and development of the library symbol and the history of its acceptance by the American Library Association (ALA) and the Canadian Library Association (CLA). Suggestions are made for its use. (CLB)

  13. The American Public Library. Research Report.

    ERIC Educational Resources Information Center

    Sager, Donald J.

    This analysis of data from major library studies provides a wide range of information on public libraries in America in the 1970's. Following a discussion of the history and stated purpose of American public libraries, figures are presented for library size, population served, area served, governing bodies, financial support, revenue allocation,…

  14. Library Service to Unions: A Historical Overview.

    ERIC Educational Resources Information Center

    Hubbard, Elizabeth Ann

    2002-01-01

    Reviews the evolution of public libraries, the origins of today's labor movement, and the role of the AFL-CIO/ALA (American Federation of Labor (AFL)-Congress of Industrial Organizations (CIO)/American Library Association (ALA))Joint Committee on Library Service to Labor Groups. Defines misunderstandings and lack of trust between libraries and…

  15. National Museum of American History Branch Library.

    ERIC Educational Resources Information Center

    Ratner, Rhoda S.

    1986-01-01

    Subject concentration in the National Museum of American History Branch Library, a part of Smithsonian Institution Libraries system, is in the history of science and technology and American history, with emphasis on material culture and on documenting and servicing the museum's collections. Special collections include trade literature and…

  16. African American Undergraduates and the Academic Library

    ERIC Educational Resources Information Center

    Whitmire, Ethelene

    2006-01-01

    This study examines the academic library experiences of African American undergraduates attending a research university in the Midwest. Data collection techniques included questionnaires and ethnographic observations. The results indicated that African American undergraduates are using the academic library primarily to read and to study with their…

  17. Stick to the ALA Plan

    ERIC Educational Resources Information Center

    Berry, John N., III

    2007-01-01

    One candidate for president-elect of the American Library Association (ALA) is a woman, the other is a man. One can tell them apart by looking at them. But Nancy Davenport and James Rettig are not that far apart on the issues that confront the old association and the profession it serves. They have selected slightly different emphases for their…

  18. ALA Conference 2009: Chicago Hope

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    There is joy among those who have the funds to go to Chicago for the American Library Association (ALA) annual conference, July 9-15. Every librarian knows there is nothing better than a Chicago gathering, with the city's wonderful haunts, museums, restaurants, and fine memories of past conferences. The conference program covers nearly every…

  19. Community, Individualism, and the American Public Library.

    ERIC Educational Resources Information Center

    Birdsall, William F.

    1985-01-01

    This essay addresses the ambiguity and confusion arising out of two values that have been embodied in American public library ideology since at least the last quarter of the nineteenth century: concept of the public library as community institution; the public library's emphasis on service to the individual. (27 references) (EJS)

  20. American Indian Studies. Library Research Guide.

    ERIC Educational Resources Information Center

    White, Phillip M.

    This guide to sources for students at San Diego State University doing library research in topics related to American Indian Studies begins by noting that information on North American Indians can be found in a variety of subject disciplines including history, anthropology, education, sociology, health care, law, business, and politics. The…

  1. Geographical Bibliography for American Libraries.

    ERIC Educational Resources Information Center

    Harris, Chauncy D., Ed.

    The purpose of this extensive annotated bibliography is to assist libraries in the United States, Canada, and other countries to identify, select, and secure publications of value in geography that are appropriate for the purposes and resources of each library collection. More than 2900 entries, published between 1970 and 1984, are arranged by…

  2. Younger Americans' Reading and Library Habits

    ERIC Educational Resources Information Center

    Zickuhr, Kathryn; Rainie, Lee; Purcell, Kristen; Madden, Mary; Brenner, Joanna

    2012-01-01

    More than eight in ten Americans between the ages of 16 and 29 read a book in the past year, and six in ten used their local public library. At the youngest end of the spectrum, high schoolers in their late teens (ages 16-17) and college-aged young adults (ages 18-24) are especially likely to have read a book or used the library in the past 12…

  3. American Sculpture and the Library of Congress

    ERIC Educational Resources Information Center

    Somma, Thomas P.

    2010-01-01

    The Thomas Jefferson Building of the Library of Congress is one of the more significant public structures in American architecture, due for the most part to its wealth and quality of decoration, including an extensive sculptural program executed in 1894-97. The architects entrusted the program to a committee of three prominent sculptors, J. Q. A.…

  4. American Museum of Natural History Library.

    ERIC Educational Resources Information Center

    Root, Nina J.

    1986-01-01

    Discusses the history, facilities, collections and services offered by the American Museum of Natural History Library. Also described are collection organization, work on preservation of materials, grant-funded projects, and the outlook for the future. Statistics provided include date founded, director, collection and staff size, and main subjects…

  5. Service to the Labor Community: A Public Library Perspective.

    ERIC Educational Resources Information Center

    Sparanese, Ann C.

    2002-01-01

    Discusses the relationship between public libraries and the labor movement. Highlights include the literature of labor and libraries; historical background; labor education; the role of the AFL-CIO/ALA (American Federation of Labor (AFL)-Congress of Industrial Organizations (CIO)/American Library Association (ALA)) Joint Committee on Library…

  6. ALA 2010: Where to Eat in DC

    ERIC Educational Resources Information Center

    Library Journal, 2010

    2010-01-01

    As host to visitors and transplants from around the world, Washington, DC, benefits from the constant infusion of different cultures. Although most neighborhoods lack a unified culinary flavor, make no mistake: DC is a city of distinctive areas, each with its own style, ensuring that hungry American Library Association (ALA) 2010 conference…

  7. School Libraries Count! A National Survey of School Library Media Programs, 2007

    ERIC Educational Resources Information Center

    American Association of School Librarians (NJ1), 2007

    2007-01-01

    The American Library Association's (ALA's) divisions for academic and public libraries--the Association of College and Research Libraries (ACRL) and the Public Library Association (PLA)--have long collected and reported annual statistics about the types of libraries they represent. This year, 2007, the American Association of School Librarians…

  8. ALA 2010 Midwinter Meeting: The Price to Participate

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    While the library economy continues its downward slide, the cost of attending the American Library Association (ALA) Midwinter Meeting seems as high as ever. That is the price of professional participation. These days it seems a bit too high and tends to limit involvement in the old association to librarians in the higher echelons of the field.…

  9. National Association and Organization Reports. American Library Association; Association of American Publishers; American Booksellers Association; Association of Research Libraries; Scholarly Publishing and Academic Resources Coalition (SPARC); Council on Library and Information Resources.

    ERIC Educational Resources Information Center

    Berry, John W.; Platt, Judith; Hoynes, Michael; Webster, Duane E.; Johnson, Richard; Smith, Kathlin

    2002-01-01

    This section includes reports from the American Library Association, Association of American Publishers, American Booksellers Association, Association of Research Libraries, Scholarly Publishing and Academic Resources Coalition (SPARC), and Council on Library and Information Resources. (LRW)

  10. The Use of Public Libraries by Native Americans

    ERIC Educational Resources Information Center

    Burke, Susan K.

    2007-01-01

    Library services to Native Americans have expanded greatly in the past several decades, but more work still needs to be done to provide for the information needs of Native Americans. Data from the U.S. Current Population Survey were used to compare library use rates of Native American households to rates of Anglo households. Results show that…

  11. Federal Legislative Policy of the American Library Association.

    ERIC Educational Resources Information Center

    American Library Association, Chicago, IL. Legislation Committee.

    The American Library Association's policy on federal legislation is based on its objectives of promoting and improving library service and librarianship. Representing those who use libraries as well as those who operate them, the Association is a source of information on libraries and information services for those concerned with formulating and…

  12. 2. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, Maine THE BUILDING WITH ITS FIRST ADDITION OF 1893-94 - Hubbard Free Library, 115 Second Street, Hallowell, Kennebec County, ME

  13. 3. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, Maine TRAIN DAMAGE TO WEST (REAR) WALL OF SECOND ADDITION, EARLY 20th CENTURY - Hubbard Free Library, 115 Second Street, Hallowell, Kennebec County, ME

  14. 1. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, Maine THE ORIGINAL BUILDING SHORTLY AFTER COMPLETION IN 1879 - Hubbard Free Library, 115 Second Street, Hallowell, Kennebec County, ME

  15. 8. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Source: Hubbard Free Library, Hallowell, Maine INTERIOR VIEW TOWARD THE WEST WITH FIRST AND SECOND ADDITIONS, CIRCA 1900 - Hubbard Free Library, 115 Second Street, Hallowell, Kennebec County, ME

  16. 1. Historic American Buildings Survey San Francisco Examiner Library EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey San Francisco Examiner Library EAST ELEVATION - Presidio of San Francisco, Old Station Hospital, Funston Avenue & Lincoln Boulevard, San Francisco, San Francisco County, CA

  17. 21. Historic American Buildings Survey Photocopy courtesy of Library of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Historic American Buildings Survey Photocopy courtesy of Library of Congress Pictorial Archives of Early American Architecture C & O CANAL AT WISCONSIN AVENUE - Chesapeake & Ohio Canal, Georgetown Section, East & West parallel to M Street Northwest, Washington, District of Columbia, DC

  18. 17. Historic American Buildings Survey Original at Library of Congress, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Historic American Buildings Survey Original at Library of Congress, Pictorial Archives of Early American Architecture Arthur A. Snyder, Photographer AQUEDUCT BRIDGE, FEBRUARY 2,1900 - Potomac Aqueduct, Georgetown abutment at Georgetown waterfront, Washington, District of Columbia, DC

  19. 9. Historic American Buildings Survey Photocopy by Library of Congress, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Photocopy by Library of Congress, August 8, 1972 From American Architect and Building News, Sept. 29, 1906 PORTE-COCHERE, 1906 - Herbert Wadsworth House, 1801 Massachusetts Avenue Northwest, Washington, District of Columbia, DC

  20. 8. Historic American Buildings Survey Photocopy: Original in the Library ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Photocopy: Original in the Library of Congress Pictorial Archives of Early American Architecture EAST (FRONT) ELEVATION C. 1899 - Adams-Mason House, 1072 Thomas Jefferson Street Northwest, Washington, District of Columbia, DC

  1. A Circle of Colleagues Meet in the Loop: ALA Midwinter Report.

    ERIC Educational Resources Information Center

    Wilson Library Bulletin, 1987

    1987-01-01

    Highlights the American Library Association (ALA) 1987 Midwinter Conference, including the aftermath of the Attorney General's report on pornography; Congressional pay equity bills; library copying rights; federal librarians' decline in membership and privatization; public library planning, role setting, and output measures manuals; and summaries…

  2. "LJ" Report "Anaheim, ALA 2008": Amid the Fantasy, Doses of Reality

    ERIC Educational Resources Information Center

    Blumenstein, Lynn; Berry, John; Fialkoff, Francine; Fox, Bette-Lee; Hadro, Josh; Horrocks, Norman; Oder, Norman; Roncevic, Mirela

    2008-01-01

    If the resort city of Anaheim, California, home of Disneyland and its "imagineers," marked a departure from the urban reality of the typical American Library Association (ALA) annual conference, it was impossible, at this 2008 meeting, to avoid urgent library issues. How do libraries maintain their value and cultural presence as users turn to the…

  3. ALA Office for Intellectual Freedom: Who We Are and How We Help Librarians

    ERIC Educational Resources Information Center

    Pekoll, Kristin

    2015-01-01

    The American Library Association's (ALA's) Office for Intellectual Freedom (OIF) strives to educate librarians and the public about the nature and importance of intellectual freedom in libraries, and it will celebrate its fiftieth anniversary in 2017. Libraries are a forum for information and ideas (under the First Amendment), and librarians are…

  4. A Review of Curriculum Development for Library Technicians in Junior Colleges.

    ERIC Educational Resources Information Center

    Spyers-Duran, Peter

    The Library Technician Program of community colleges has been endorsed by the American Library Association (ALA). The ALA's definition of a library Technical Assistant is "a person with certain specifically library-related skills--in preliminary bibliographic searching, for example, or utilization of certain mechanical equipment--the performance…

  5. School Library Ethics--A Battle of Hats

    ERIC Educational Resources Information Center

    Simpson, Carol

    2004-01-01

    This article focuses on issues concerning school library ethics. In the U.S., American Library Association (ALA) has established a code of ethics for this profession. However, the school library is not the only one affected by the ethical code of the ALA. Since teachers have their own codes of ethics, librarians have now assumed yet another mantle…

  6. Knowledge Organisation Systems in North American Digital Library Collections

    ERIC Educational Resources Information Center

    Shiri, Ali; Chase-Kruszewski, Sarah

    2009-01-01

    Purpose: The purpose of this paper is to report an investigation into the types of knowledge organisation systems (KOSs) utilised in North American digital library collections. Design/methodology/approach: The paper identifies, analyses and deep scans online North American hosted digital libraries. It reviews the literature related to the…

  7. Native American Library Services: Reclaiming the Past, Designing the Future.

    ERIC Educational Resources Information Center

    Patterson, Lotsee

    1992-01-01

    Results of the 1991 White House Pre-Conference and White House Conference on Library and Information Services included several resolutions to strengthen the library services of Native American tribal and reservation libraries. Resolutions called for increased federal support for family literacy programs, staffing, and research studies and for…

  8. Learning Library Resources by Researching Latin American Topics.

    ERIC Educational Resources Information Center

    Finkelston, Candace

    This document presents a module on learning library resources by researching Latin American topics to be used in the Use of Library Resources course at St. Louis Community College at Meramec (Missouri). The goal of the module (to give students a basic knowledge of library resources and to introduce them to Latin America by researching Latin…

  9. American Library History Literature, 1947-1997: Theoretical Perspectives?

    ERIC Educational Resources Information Center

    Wiegand, Wayne A.

    2000-01-01

    Reviews 50 years of published research literature in American library history that shows a lack of theoretical perspective. Suggests that library historians should join with critical theorists and with social and cultural historians to help place the library in a larger context of social and cultural forces. (Contains 131 references.) (LRW)

  10. International Library Manpower; Education and Placement in North America (ALA Preconference Institute. Detroit, Michigan; June 26-27, 1970). Papers and Speeches.

    ERIC Educational Resources Information Center

    American Library Association, Chicago, IL. Office for Library Education.

    The four papers in this volume of institute proceedings present: (1) a retrospective, subjective look at foreign-trained librarians employed in North American libraries and foreign students in North American library education programs, (2) statistical analyses of current policies and practices relating to the employment of foreign-trained…

  11. Merchants of Light: The Paris Library School, Internationalism, and the Globalization of a Profession

    ERIC Educational Resources Information Center

    Witt, Steven

    2013-01-01

    Amid growing isolationism after World War I, the American Library Association transferred its wartime programs to train librarians in Europe and promote the American model of public libraries. Working in collaboration with American philanthropists and members of the French library community, ALA established a permanent library school in Paris that…

  12. Manual for Providing Library Services to Indians and Mexican Americans.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Rural Education and Small Schools, Las Cruces, NM.

    The manual was compiled by participants of an institute designed to train librarians to work with American Indians and Mexican Americans. Information is provided to aid library personnel in understanding the cultural backgrounds of these minority groups. Criteria for selecting books for and about Mexican Americans and Indians are included, as well…

  13. Education and Manpower in Tennessee Libraries.

    ERIC Educational Resources Information Center

    Ward, James E.

    All of the libraries in Tennessee were surveyed in an effort to determine both the manpower needs and the classification of all library personnel on the basis of the newly-adopted categories in the American Library Association (ALA) policy on library education and manpower. The purpose of the study was to reveal information pertinent to library…

  14. Library Employment Sources on the Internet

    ERIC Educational Resources Information Center

    Barr, Catherine

    2012-01-01

    This article presents a list of online resources for library job seekers. This includes general sites/portals like American Library Association (ALA): Education & Careers and Canadian Library Association: Library Careers. It also includes sites by sector, employment agencies/commercial services, listservs and networking sites.

  15. Reality Bites: The Collision of Rhetoric, Rights, and Reality and the Library Bill of Rights.

    ERIC Educational Resources Information Center

    Wiegand, Shirley A.

    1996-01-01

    Argues that the library profession should separate rhetoric from rights in the Library Bill of Rights to create two documents: a true Bill of Rights including only those principles demanded by the U.S. Constitution, and a Statement of Philosophy based on the American Library Association's (ALA) Code of Ethics. Contains the ALA Code of Ethics. (PEN)

  16. Swedish School Library Programs: An American View.

    ERIC Educational Resources Information Center

    Downes, Valerie J.

    1989-01-01

    This article presents the results of a study which examined schools and libraries in Sweden. During a five-month period 40 libraries and 150 classrooms were surveyed to assess the adequacy of their facilities, budgets, collections, staffs, and services. It was found that: (1) the size of the school library facilities depended on the type of…

  17. 4. Historic American Buildings Survey, Owned by the Library of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Owned by the Library of Congress, Cartography Division, See Catalog of Graphic Material #49, PHOTOCOPY OF THE 1777 MONTRESSOR MAP OF FORT MIFFLIN. - Fort Mifflin, Mud Island, Marine & Penrose Ferry Roads, Philadelphia, Philadelphia County, PA

  18. 1. Historic American Buildings Survey, Original from Butler Library, Columbia ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Original from Butler Library, Columbia University, See Catalog of Graphic Material #14, PHOTOCOPY OF PLAN, 1777. - Fort Mifflin, Mud Island, Marine & Penrose Ferry Roads, Philadelphia, Philadelphia County, PA

  19. 2. Historic American Buildings Survey, Yale University Library, Map Collection, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Yale University Library, Map Collection, See Catalog of Graphic Material #13 PHOTOCOPY OF PLAN BY CHARLES BLASKOWITZ, 1777. - Fort Mifflin, Mud Island, Marine & Penrose Ferry Roads, Philadelphia, Philadelphia County, PA

  20. 4. Historic American Buildings Survey California State Library Sacramento, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey California State Library Sacramento, California Photo Taken: 1860 Re-photo: March 1940 EAST FRONT - CENTRAL SECTION - Custom House, Custom House Plaza, Monterey, Monterey County, CA

  1. 52. Historic American Buildings Survey California State Library Sacramento, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    52. Historic American Buildings Survey California State Library Sacramento, California Original: June 13, 1918 Re-photo: February 1940 DETAIL OF AQUEDUCT - Mission San Antonio de Padua, Hunter Liggett Military Reservation, Jolon, Monterey County, CA

  2. 8. Historic American Buildings Survey Illinois State Historical Library, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Illinois State Historical Library, Photographer SECOND FLOOR HALL LOOKING SOUTH INTO STUDY - David Davis Mansion, Monroe & Davis Streets, Bloomington, McLean County, IL

  3. 2. Historic American Buildings Survey California State Library Collection California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey California State Library Collection California Section Photo of Thompson & West Engraving of 1880 COMBINED FRONTAGE OF THE THREE BUILDINGS - Big Four Building, 220-226 K Street, Sacramento, Sacramento County, CA

  4. 29. Historic American Buildings Survey California State Library Sacramento, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Historic American Buildings Survey California State Library Sacramento, California Early 1900's Rephoto: February 1940 VIEW FROM SOUTHWEST - Mission San Antonio de Padua, Hunter Liggett Military Reservation, Jolon, Monterey County, CA

  5. 1. Historic American Buildings Survey California State Library Collection Photo ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey California State Library Collection Photo from Cerinda Evans' Biography of Huntington, Vol. I Rephoto, 1962 VIEW OF THE HUNTINGTON & HOPKINS STORE - 1861 - 1877 - Big Four Building, 220-226 K Street, Sacramento, Sacramento County, CA

  6. 33. Historic American Buildings Survey From California State Library Sacramento, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Historic American Buildings Survey From California State Library Sacramento, California Original: 1860's Re-photo: February 1940 INTERIOR OF CHURCH BEFORE RESTORATION - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

  7. 1. Historic American Buildings Survey Photocopy, Art Library, Yale University ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Photocopy, Art Library, Yale University FRONT (EAST) ELEVATION PRIOR RO ADDITION OF 1896 - James Dwight Dana House, 24 Hillhouse Avenue, New Haven, New Haven County, CT

  8. 3. Historic American Buildings Survey California State Library Collection Sacramento ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey California State Library Collection Sacramento Co. History Thompson & West Sketch of 1880 Rephoto 1960 NORTHEAST CORNER - B. F. Hastings Bank Building, 128-132 J Street, Sacramento, Sacramento County, CA

  9. 3. Historic American Buildings Survey Photocopy: Courtesy of Library of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Photocopy: Courtesy of Library of Congress undated (after c. 1873) NORTH AND WEST SIDES - United States General Post Office, Between Seventh, Eighth, E, & F Streets, Northwest, Washington, District of Columbia, DC

  10. 32. Historic American Buildings Survey From California State Library Sacramento, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Historic American Buildings Survey From California State Library Sacramento, California Original: Re-photo: February 1940 DETAIL OF ENTRANCE (East Elevation) - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

  11. 6. Historic American Buildings Survey From California State Library Sacramento, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey From California State Library Sacramento, California Original: Ante 1860 Re-photo: February 1940 VIEW FROM SOUTHEAST - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

  12. 2. Historic American Buildings Survey Photocopy courtesy of the Library ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Photocopy courtesy of the Library of Congress VIEW NORTH UP SEVENTH STREET - Firemen's Insurance Company Building, 303 Seventh Street Northwest, Washington, District of Columbia, DC

  13. 22. Historic American Buildings Survey Photocopy courtesy of the Library ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Historic American Buildings Survey Photocopy courtesy of the Library of Congress C& O CANAL AT WISCONSIN AVENUE - Chesapeake & Ohio Canal, Georgetown Section, East & West parallel to M Street Northwest, Washington, District of Columbia, DC

  14. 2. Historic American Buildings Survey San Francisco Chronicle Library San ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey San Francisco Chronicle Library San Francisco, California Year Built: 1834 Photo Taken: About 1925 VIEW FROM EAST - General Sherman Quarters, 464 Calle Principal, Monterey, Monterey County, CA

  15. A Search for Meaning: American Library Metaphors, 1876-1926.

    ERIC Educational Resources Information Center

    Nardini, Robert F.

    2001-01-01

    Discusses the use of metaphor during the first 50 years of the modern American library movement in the hopes of inspiring one another, recruit newcomers to the profession, and to influence outsiders. Examines references to the library in terms of more visible institutions such as schools, universities, the church, and business and industry.…

  16. African American Women Leaders in Academic Research Libraries

    ERIC Educational Resources Information Center

    Epps, Sharon K.

    2008-01-01

    Effective leadership and increasing diversity are central concerns in the library profession. Using qualitative interviewing and research methods, this study identifies the attributes, knowledge, and skills that African American women need in order to be successful leaders in today's Association of Research Libraries (ARL). These findings indicate…

  17. American Indian Resource Manual for Public Libraries. Bulletin No. 92429.

    ERIC Educational Resources Information Center

    de Usabel, Frances; Roeber, Jane A.

    This manual, written primarily for Wisconsin public librarians, is designed to provide practical assistance to those who wish to expand public library collections of American Indian (defined as people in the United States and Canada who trace their lineage to the original habitants of these lands) resources and to improve related library programs…

  18. A Statistical Analysis of Library School Deans' Publications.

    ERIC Educational Resources Information Center

    Kilpela, Raymond

    The purpose of this study was to ascertain the extent to which deans holding office in 1983 in American Library Association (ALA) accredited graduate library education programs fulfilled the expectations of academia and the ALA "Standards'" requirement with respect to sustained productive scholarship and evidence of aptitude for research through…

  19. American Indian Studies. Library Research Guide. 2nd Edition.

    ERIC Educational Resources Information Center

    White, Phillip M.

    This guide to sources for San Diego (California) State University students doing library research on topics related to American Indian Studies begins by noting that information on North American Indians can be found in a variety of subject disciplines including history, anthropology, education, sociology, health care, law, business, and politics.…

  20. The "Ever Green" Interpretations of the "Library Bill of Rights"

    ERIC Educational Resources Information Center

    Adams, Helen R.

    2010-01-01

    The American Library Association's (ALA) "Library Bill of Rights" is important to school librarians because it provides the philosophical structure for intellectual freedom in school libraries and asserts the rights of minors. It states: "A person's right to use a library should not be denied or abridged because of origin, age, background, or…

  1. Voters Step up: Library Referenda 2009

    ERIC Educational Resources Information Center

    Dempsey, Beth

    2010-01-01

    For libraries, the impact of the derailed economy was felt more fully in 2009 than in 2008, as tax revenues decreased and public funds dwindled. By February 2009, the American Library Association (ALA) reported from a survey of its Chief Officers of State Library Agencies (COSLA) that 41 percent of states expected declining state funding for…

  2. The Evolving Educational Mission of the Library.

    ERIC Educational Resources Information Center

    Baker, Betsy, Ed.; Litzinger, Mary Ellen, Ed.

    At the 1989 annual meeting of the American Library Association (ALA), the Association of College and Research Libraries (ACRL) used a think tank as a dynamic mechanism for exploring future directions both in the discipline of library user education and for the Bibliographic Instruction (BI) Section of ACRL. Discussion centered on the following…

  3. The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes

    PubMed Central

    Salto, Lorena M.; Bu, Liming; Beeson, W. Lawrence; Firek, Anthony; Cordero-MacIntyre, Zaida; De Leon, Marino

    2015-01-01

    The alanine to threonine amino acid substitution at codon 54 (Ala54Thr) of the intestinal fatty acid binding protein (FABP2) has been associated with elevated levels of insulin and blood glucose as well as with dyslipidemia. The aim of this study was to characterize the effect of this FABP2 polymorphism in Mexican-Americans with type 2 diabetes (T2D) in the context of a three-month intervention to determine if the polymorphism differentially modulates selected clinical outcomes. For this study, we genotyped 43 participant samples and performed post-hoc outcome analysis of the profile changes in fasting blood glucose, HbA1c, insulin, lipid panel and body composition, stratified by the Ala54Thr polymorphism. Our results show that the Thr54 allele carriers (those who were heterozygous or homozygous for the threonine-encoding allele) had lower HDL cholesterol and higher triglyceride levels at baseline compared to the Ala54 homozygotes (those who were homozygous for the alanine-encoding allele). Both groups made clinically important improvements in lipid profiles and glycemic control as a response to the intervention. Whereas the Ala54 homozygotes decreased HDL cholesterol in the context of an overall total cholesterol decrease, Thr54 allele carriers increased HDL cholesterol as part of an overall total cholesterol decrease. We conclude that the Ala54Thr polymorphism of FABP2 modulates HDL cholesterol in Mexican-Americans with T2D and that Thr54 allele carriers may be responsive in interventions that include dietary changes. PMID:26703680

  4. The Mexican American in Library Materials.

    ERIC Educational Resources Information Center

    Hyland, Anne

    This resource guide provides the librarian with a selected bibliography of available materials which help to dispel stereotyping and inaccuracy in Mexican American literature and social studies materials. According to the author, although bad minority literature and materials are abundant, good materials are being produced. Teachers and librarians…

  5. Library Guide: Latin American Literature, 2001.

    ERIC Educational Resources Information Center

    de Sumar, Juanita Jara, Comp.

    Intended for use by those conducting research in Latin American literature written in Spanish, this guide contains annotations for a wide range of selected works. The guide is divided into the seven sections: (1) General Encyclopedias (1 annotation); (2) Guides to the Literature (4 annotations); (3) Literary Encyclopedias, Dictionaries and…

  6. Profiles of Constituent Groups: Indicators of Effectiveness of Schools of Library and Information Studies.

    ERIC Educational Resources Information Center

    Watson-Boone, Rebecca; Weingand, Darlene E.

    1995-01-01

    Reports on indicators of effectiveness of schools of library and information studies derived from surveying and profiling four American Library Association (ALA) constituent groups: ALA's Committee on Accreditation, senior academic administrators, alumni and alumnae, and employers. The methodology and results are discussed, and a table of…

  7. 7. Historic American Buildings Survey PHOTOCOPY CA. 1916 OF LIBRARY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey PHOTOCOPY CA. 1916 OF LIBRARY LOOKING INTO NORTHEAST OF ROOM; ROOM FEATURES INTRICATE MAHOGANY CARVINGS, ROCKWOOD POTTERY FIREPLACE, WALLS COVERED WITH CARVED DESIGNS ON PRESSED LEATHER. Original in Collections of Marian College - James A. Allison Mansion, 3200 Coldspring Road, Indianapolis, Marion County, IN

  8. Financing North American medical libraries in the nineteenth century*

    PubMed Central

    Belleh, Godfrey S.; Luft, Eric v. d.

    2001-01-01

    Culture not only justifies the existence of libraries but also determines the level of funding libraries receive for development. Cultural appreciation of the importance of libraries encourages their funding; lack of such appreciation discourages it. Medical library development is driven by culture in general and the culture of physicians in particular. Nineteenth-century North American medical library funding reflected the impact of physician culture in three phases: (1) Before the dawn of anesthesia (1840s) and antisepsis (1860s), when the wisdom of elders contained in books was venerated, libraries were well supported. (2) In the last third of the nineteenth century, as modern medicine grew and as physicians emphasized the practical and the present, rather than books, support for medical libraries declined. (3) By the 1890s, this attitude had changed because physicians had come to realize that, without both old and new medical literature readily available, they could not keep up with rapidly changing current clinical practice or research. Thus, “The Medical Library Movement” heralded the turn of the century. PMID:11837261

  9. Library and Information Science Journal Prestige as Assessed by Library and Information Science Faculty

    ERIC Educational Resources Information Center

    Manzari, Laura

    2013-01-01

    This prestige study surveyed full-time faculty of American Library Association (ALA)-accredited programs in library and information studies regarding library and information science (LIS) journals. Faculty were asked to rate a list of eighty-nine LIS journals on a scale from 1 to 5 based on each journal's importance to their research and teaching.…

  10. Hey, Small Spender: An Insider's Guide to Navigating ALA's Chicago Conference on the Cheap

    ERIC Educational Resources Information Center

    School Library Journal, 2009

    2009-01-01

    This article presents an insider's guide to navigating the American Library Association's (ALA) annual conference in Chicago on July 9-15. As for the extracurricular activities, Chicago has a lot to offer. This article provides tips from the arts and entertainment bible "Time Out Chicago" on where to go and what to do (on a limited budget) while…

  11. Shifting with the Paradigm: LJ's Picks & Pans for ALA in Disneyland

    ERIC Educational Resources Information Center

    Berry, John N., III

    2008-01-01

    The feelings of librarians planning for the American Library Association (ALA) conference at Disneyland (aka Anaheim, California, June 26-July 2) range from moderate pleasure to dread. Some remember the joys and difficulties of Orlando, especially the exorbitant cab fares and mediocre restaurants. Others quail at screaming kids and tourists in…

  12. Members of the Club: A Look at One Hundred ALA Presidents. Occasional Paper Number 182.

    ERIC Educational Resources Information Center

    Wiegand, Wayne A.; Steffens, Dorothy

    A survey of the personal, socioeconomic, and professional characteristics of the 100 men and women who served as President to the American Library Association (ALA) between 1876 and 1986 was undertaken to identify those socioeconomic and professional characteristics whose frequency distributions remained relatively constant for all 100 members of…

  13. Generation Xers Create a Campaign for the Library.

    ERIC Educational Resources Information Center

    Kelly, Joyce

    1997-01-01

    The American Library Association (ALA) enlisted the help of design students at the University of Illinois/Chicago to produce an advertising campaign for the nation's libraries. The campaign, which took 15 weeks to prepare, resulted in bold, unusual, sometimes ambiguous, and thought-provoking ads. It embodied the relationship between libraries and…

  14. Statement on Behalf of the New York Library Association Prepared for the Attorney General's Commission on Pornography Hearings in New York City on January 22, 1986.

    ERIC Educational Resources Information Center

    Cohen, David

    This statement supports and endorses the Intellectual Freedom policies of the American Library Association (ALA) as exemplified by the ALA Bill of Rights. The case of Pico v. Island Trees Free School District provides a legal precedent in support of the idea that decisions to remove materials from the school library cannot be based on personal…

  15. Pennsylvania Library Association, Membership Survey, 1994.

    ERIC Educational Resources Information Center

    Obringer, Dave

    This report contains the results of a survey sent to 2,883 librarians throughout Pennsylvania, both members and nonmembers of the Pennsylvania Library Association (PLA). The nonmembers of PLA were members of the American Library Association (ALA), however. The total response rate was 21% (n=620). There were recurring themes in the responses from…

  16. Good Fences Make Bad Libraries: Rethinking Binary Constructions of Employment in Academic Libraries

    ERIC Educational Resources Information Center

    Jones, Phillip J.; Stivers, James

    2004-01-01

    Academic libraries segregate their personnel into professional and supportive categories almost exclusively on the basis of the American Library Association's (ALA) accredited master's degree. This article surveys the professional discourses of academic librarians and adopts a critical theory methodology to critique this practice. The authors…

  17. NCIP Manual. Manual for the North American Inventory of Research Library Collections. Revised Edition.

    ERIC Educational Resources Information Center

    Reed-Scott, Jutta

    The Association of Research Libraries' Office of Management Services (OMS), working with the Research Libraries Group, Inc. (RLG), began the North American Collections Inventory Project (NCIP) in July 1983 as a cooperative effort intended eventually to involve research libraries throughout the United States and Canada. The project's long-term goal…

  18. The Library Bill of Rights in the 1960s: One Profession, One Ethic.

    ERIC Educational Resources Information Center

    Samek, Toni

    1996-01-01

    Discusses two vying interpretations of the Library Bill of Rights (intellectual freedom seen as pure neutrality or as social responsibility) and highlights conflicts that these views created within the American Library Association (ALA) from 1967 to 1973. Outlines early history of the Social Responsibilities Round Table of Libraries and the…

  19. The I-Word: Semantics and Substance in Library and Information Studies Education.

    ERIC Educational Resources Information Center

    Van Fleet, Connie; Wallace, Danny P.

    2002-01-01

    Reviews the introduction of the word "information" into the field of library science. Highlights include ALA (American Library Association) accreditation; the inclusion of the word "information" in names of institutions, academic units, and degree programs; and the question of whether programs really prepare graduates for careers in libraries.…

  20. North American Metropolitan City Libraries Publications 1966-1971

    ERIC Educational Resources Information Center

    International Library Review, 1972

    1972-01-01

    The publications in this list are summarized under the following headings: central libraries, district (regional) libraries, and local (communal) libraries; and under the social objectives of libraries which can be grouped as civic, cultural, educational, industrial, recreational, research and social welfare. A subject and key-word index is…

  1. Libraries in the United States and the International Year of Disabled Persons: Highlights of the Year--1981.

    ERIC Educational Resources Information Center

    Dalton, Phyllis I., Comp.

    In response to the United Nations' declaration of 1981 as the International Year of Disabled Persons (IYDP), the Association of Specialized and Cooperative Library Agencies (ASCLA) of the American Library Association (ALA) set up an IYDP committee to carry out the objectives of the year. This document, based on state library reports and other…

  2. Best Small Library in American 2008: Chelsea District Library--A Michigan Model

    ERIC Educational Resources Information Center

    Berry, John N., III

    2008-01-01

    This article features Chelsea District Library (CDL), Michigan, which claims recognition as the 2008 Best Small Library in America, an award sponsored by "Library Journal" and the Bill & Melinda Gates Foundation. The aggressively responsive staff of CDL has created a model for small libraries all over America. There, careful research, proactive…

  3. 41. Historic American Buildings Survey San Francisco CallBulletin Library San ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. Historic American Buildings Survey San Francisco Call-Bulletin Library San Francisco, California INTERIOR VIEW OF CHURCH BEFORE RESTORATION - 1934 - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

  4. 3. Historic American Buildings Survey From the S.F. Chronicle Library ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey From the S.F. Chronicle Library Circa 1930 OFFICERS' CLUB - NORTH ELEVATION - Presidio of San Francisco, Commandancia, Moraga Avenue, San Francisco, San Francisco County, CA

  5. Library Media Specialists and Spirituality in Schools: Native American Images as a Beginning.

    ERIC Educational Resources Information Center

    Barron, Daniel D.

    2002-01-01

    Discussion of spirituality in schools focuses on Native American images, especially as used for school mascots and product marketing. Includes various resources, both electronic and printed, that are helpful to school library media specialists as well as other educators. (LRW)

  6. 3. Historic American Buildings Survey S.F. Chronicle Library Circa 1906 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey S.F. Chronicle Library Circa 1906 RUINS, AFTER EARTHQUAKE AND FIRE (Looking North) - St. Francis Church, Historic View, 610 Vallejo Street, San Francisco, San Francisco County, CA

  7. American Indian Studies, Multiculturalism, and the Academic Library

    ERIC Educational Resources Information Center

    Alexander, David L.

    2013-01-01

    The current status of multicultural and diversity efforts suggests the need for incorporating into the discussion of librarianship an understanding of previously underrepresented populations such as the American Indian. American Indian Studies speaks from the American Indian perspective and addresses the contemporary condition of American Indians.…

  8. Diversity: Then Is Now. Commentary on Carter, J. R. (1978) Multicultural Graduate Library Education. (Journal of Education for Librarianship, 18(4), 295-314)

    ERIC Educational Resources Information Center

    Roy, Lorienne

    2015-01-01

    Robbins Carter's portrait of the librarian workforce is still true. According to the latest American Library Association (ALA) demographics, the profile of today's librarian is that of a white (87.1 percent) woman (80.7 percent) of middle age (57.1 percent, age 45 or older) (ALA, 2013). Despite these data, support for increased diversity is…

  9. American Indian Community Library Demonstration Project. First--Fourth Quarterly Reports, 1976-77.

    ERIC Educational Resources Information Center

    Smith, Lotsee

    Quarterly progress reports present the major accomplishments and activities of four American Indian Community Library Demonstration projects funded during 1976-1977. These projects established library services in New Mexico for four previously unserved Pueblo communities: Cochiti, Santo Domingo, Sky City, and Laguna. For each quarter, an overall…

  10. Library Use Instruction in Selected American Colleges. Occasional Papers No. 134.

    ERIC Educational Resources Information Center

    Miller, Stuart Wayne

    Limited to programs aimed at undergraduate students in American college libraries, this paper describes the development of the concept of library skills instruction and discusses current instructional programs in 13 colleges: Brown, Washington and Lee, Manhattanville, Occidental, Dillard, Dickinson, Oberlin, State University College at…

  11. Faculty Status of Theological Librarians in the American Theological Library Association.

    ERIC Educational Resources Information Center

    Kemper, Ann L.

    This paper is the result of a survey of the institutional members of the American Theological Library Association. The Association of College and Research Libraries (ACRL) defines faculty status as: (1) freedom to exercise independent judgment in performance of professional duties and a formal method of performance review, (2) adoption of an…

  12. CILA: A New Approach to Problems in the Acquisition of Latin American Library Materials.

    ERIC Educational Resources Information Center

    Clouston, John Samuel

    This paper attempts to provide a contextual study of CILA--Centro Interamericano de Libros Academicos--a new scheme for the distribution of scholarly books in the Americas. Because of the scheme's peculiar relevance to the needs of Canadian academic libraries, the status of Latin American studies and relevant library collections in Canada are…

  13. The Teaching of Reference in American Library Schools. Historical Paper 4

    ERIC Educational Resources Information Center

    Cheney, Frances Neel

    2015-01-01

    In this article, the author proposes to present a superficial view of what is being taught in the 32 American Library Association accredited graduate library schools. She briefly discusses and answers the following three questions: (1) Who is teaching reference?; (2) What is being taught?; and (3) How is it being taught? [For the commentary on…

  14. Selected Thematic Priorities in American Graduate Introductory Courses to Library and Information Science.

    ERIC Educational Resources Information Center

    Nitecki, Joseph Z.

    A two-part questionnaire was mailed early in 1990 to all graduate schools of library and information science accredited by the American Library Association to solicit their views on the impact of the changing information environment on the content of introductory courses in the field. The first part focused on the administrative aspects of the…

  15. How Libraries Must Comply with the Americans with Disabilities Act (ADA).

    ERIC Educational Resources Information Center

    Foos, Donald D., Comp.; Pack, Nancy C., Comp.

    The Americans with Disabilities Act (ADA) directs public and private libraries--academic, public, school, and special--to provide services to people with disabilities that are equal to services provided to citizens without disabilities. Six chapters in this book provide information to help library administrators and staff to fully understand the…

  16. Meeting the Learning Needs of African American Youth in the Library

    ERIC Educational Resources Information Center

    Hodges, Janice; Pringle, Lajuan S.

    2013-01-01

    The African American male psyche is a complicated multi-layered mixture of outside media influences, stereotypes, peer pressure, how they see themselves, and how they think others see them. This article describes how school and public librarians can help raise the literacy efforts of young African American males. It cites the need for libraries to…

  17. The Franco-Americans of New England: A Union List of Materials in Selected Maine Libraries.

    ERIC Educational Resources Information Center

    Simano, Irene M., Comp.

    Approximately 140 bibliographic citations of periodicals, serials, and newspapers; books, pamphlets and theses; and selected articles dating from the 1890's to the present time and held in Maine libraries are included in this inventory of materials by or about Franco-American people. The term "Franco-American" as used here designates those French…

  18. Internationalization in German Academic Libraries: Moving beyond North American Perspectives

    ERIC Educational Resources Information Center

    Bordonaro, Karen; Rauchmann, Sabine

    2015-01-01

    This paper explores how internationalization is understood and experienced in German academic libraries. Its main purpose is to move the discussion of internationalization in academic libraries beyond the boundaries of English-speaking North America by investigating a European perspective. Its secondary purpose is to investigate the role of…

  19. Library Services to Indian-Americans in the United States.

    ERIC Educational Resources Information Center

    Sharman, R. N.

    1994-01-01

    Surveys the history of Indian immigration to the United States and the development of Indian collections in academic, public, and special libraries. Library services to Indian populations are discussed, with descriptions of specific collections, and suggestions are given to improve services and collections. (SLD)

  20. U.S. Information Ambassadors: The 1991-92 Library Fellows and Debriefing Report.

    ERIC Educational Resources Information Center

    Doyle, Robert P.

    The American Library Association (ALA) Library Fellows program began in 1986 with a grant from the U.S. Information Agency. The program's purpose is threefold: (1) to increase international understanding through the establishment of professional and personal relationships and the accomplishment of mutual goals; (2) to promote international sharing…

  1. International Library Horizons: Some Personal Observations. The Center for the Book, Viewpoint Series No. 24.

    ERIC Educational Resources Information Center

    Vosper, Robert

    A series of recollections, memoirs, and anecdotes, this short autobiographical sketch focuses on former American Library Association (ALA) President Robert Vosper's involvement in the international library community from World War II until the 1980s. The work opens with reminiscences of acquiring foreign materials in 1944 while working at the…

  2. The Information Ambassadors: The 1989-90 Library/Book Fellows.

    ERIC Educational Resources Information Center

    American Library Association, Chicago, IL.

    This report begins by describing the American Library Association (ALA) Library/Book Fellows program, which began with a grant from the U.S. Information Agency in 1986. The program has a threefold purpose: (1) to increase international understanding through the establishment of professional and personal relationships and the accomplishment of…

  3. Designing Effective Library Services for African American Youth

    ERIC Educational Resources Information Center

    Hughes-Hassell, Sandra

    2013-01-01

    President Obama signed the "White House Initiative on Educational Excellence for African Americans" on July 26, 2012. This executive order recognizes that many "African Americans lack equal access to highly effective teachers and principals, safe schools, and challenging college preparatory classes, and disproportionately experience…

  4. Selecting Library Materials for Mexican-American Middle Schoolers.

    ERIC Educational Resources Information Center

    York, Sherry

    1995-01-01

    This annotated bibliography includes 32 works of fiction, 43 works of nonfiction, and 10 audiovisuals and teacher resources for middle school Mexican American audiences. Discussion includes interest level and reading level for each work, publishing issues, and Mexican American stereotypes. A sidebar article provides brief biographies of 21 Mexican…

  5. The FBI's Library Awareness Program: National Security vs Government Intrusion into American Libraries [and] The KGB and the Library Target.

    ERIC Educational Resources Information Center

    Information Reports and Bibliographies, 1988

    1988-01-01

    Presents statements made to the House Judiciary Subcommittee on Civil and Constitutional Rights by representatives of the Federal Bureau of Investigation and the library community concerning the surveillance of library users' reading habits as a national security measure. An FBI study on the extent of Soviet intelligence service's utilization of…

  6. Creating Tomorrow's Technologists: Contrasting Information Technology Curriculum in North American Library and Information Science Graduate Programs against Code4lib Job Listings

    ERIC Educational Resources Information Center

    Maceli, Monica

    2015-01-01

    This research study explores technology-related course offerings in ALA-accredited library and information science (LIS) graduate programs in North America. These data are juxtaposed against a text analysis of several thousand LIS-specific technology job listings from the Code4lib jobs website. Starting in 2003, as a popular library technology…

  7. HIV-AIDS Information and the American Library Community: An Overview of Responses to the HIV-AIDS Health Crisis.

    ERIC Educational Resources Information Center

    Lukenbill, W. Bernard

    This paper presents an overview of how American libraries have responded to the health crisis caused by HIV (Human Immunodeficiency Virus) and AIDS (Acquired Immune Deficiency Syndrome). AIDS information dissemination practices of libraries and the social role which American librarians have articulated regarding their special responsibilities are…

  8. Using European Systems from a North American Library.

    ERIC Educational Resources Information Center

    Clinton, Marshall; Grenville, Sally

    1980-01-01

    Illustrates the special considerations of using European search systems from North America: steps in establishing a telephone link with the European Space Agency's system, lack of availability to North Americans of some European databases through this system, user reaction, and costs. Brief descriptions of some European databases and a connect…

  9. The Association of Academic Health Sciences Libraries' collaboration with the Association of American Medical Colleges, Medical Library Association, and other organizations

    PubMed Central

    Jenkins, Carol G.; Bader, Shelley A.

    2003-01-01

    The Association of Academic Health Sciences Libraries has made collaboration with other organizations a fundamental success strategy throughout its twenty-five year history. From the beginning its relationships with Association of American Medical Colleges and with the Medical Library Association have shaped its mission and influenced its success at promoting academic health sciences libraries' roles in their institutions. This article describes and evaluates those relationships. It also describes evolving relationships with other organizations including the National Library of Medicine and the Association of Research Libraries. PMID:12883582

  10. Resiliency in American Library Association Award Winning Juvenile Fiction: A Correlational Content Analysis

    ERIC Educational Resources Information Center

    Foreman, Michelle T.

    2010-01-01

    The purpose of this quantitative content analysis was to determine whether there was a relationship between the age, gender, or race of protagonists in contemporary American Library Association award-winning juvenile literature and the representation of resilience by those characters. Award-winning juvenile fiction and biography books were…

  11. Civic Space/Cyberspace: The American Public Library in the Information Age.

    ERIC Educational Resources Information Center

    Molz, Redmond Kathleen; Dain, Phyllis

    This book assesses the current condition and direction of the American public library. It considers the challenges and opportunities presented by new electronic technologies, changing public policy, fiscal realities, and cultural trends. The authors draw on site visits and interviews conducted across the country, as well as extensive reading of…

  12. Regional Differences in Collecting Freethought Books in American Public Libraries: A Case of Self-Censorship?

    ERIC Educational Resources Information Center

    Sloan, Stephen

    2012-01-01

    This study was conducted to determine if American public libraries located in an area of the country hostile to atheist (freethought) ideas collect atheist books at a lower rate than a region of the country more open to such ideas. The US General Social Survey was consulted to locate the contrasting regions. "New York Times" Best Seller lists were…

  13. The Immigrant in Children's Fictional Books Recommended for American Libraries, 1883-1939.

    ERIC Educational Resources Information Center

    Barr, Janet Louise Cook

    Content analysis of children's books recommended, between 1883 and 1939, for American libraries indicated that immigrants were not depicted to any great extent in the books studied. It was also found that increases and decreases in the number of recommended children's books describing immigrant characters were not correlated with immigration…

  14. The New Americans Program: Queens Borough Public Library's Service to Multilingual/Multicultural Communities.

    ERIC Educational Resources Information Center

    Chao, Sheau-yueh J.

    1993-01-01

    Describes the history and development of the Queens Borough (New York) Public Library's New Americans Program that was designed to meet the needs of a culturally and linguistically diverse community. Highlights include outreach services, language classes, collection building, and examples of specific programs for Hispanic, Chinese, and Korean…

  15. "I Have a Dream, Too!": The American Dream in Coretta Scott King Award-Winning Books

    ERIC Educational Resources Information Center

    Parsons, Linda T.; Castleman, Michele

    2011-01-01

    The Coretta Scott King (CSK) Award, instituted in 1969 and recognized as an official award by the American Library Association (ALA) in 1982, is conferred annually to an African American author and an illustrator for their outstanding contributions to literature about the Black experience for children and young adults. A partial impetus for the…

  16. The CVRP at ALA, 1975.

    ERIC Educational Resources Information Center

    Lourea, Lee Olivier, Ed.

    1975-01-01

    This California Video Resource Project (CVRP) newsletter reports the activities of the all day Video Carousel program and other video events at the 1975 American Library Association conference held in San Francisco. Excerpts of talks on selections, acquisition, and utilization of video hardware and software is included. Several video tapes are…

  17. The State of Preservation Programs in American College and Research Libraries: Building a Common Understanding and Action Agenda. Optimizing Collections and Services for Scholarly Use.

    ERIC Educational Resources Information Center

    Kenney, Anne R.; Stam, Deirdre C.

    With funding from the Institute for Museum and Library Services, the Council on Library and Information Resources, ARL (Association of Research Libraries), the University Libraries Group, and the Regional Alliance for Preservation conducted a joint study in 2001 to examine the state of preservation programs in American academic libraries. The…

  18. International Reports. International Federation of Library Associations and Institutions; A Canadian-American Librarianship or an American-Canadian Librarianship in the 21st Century?

    ERIC Educational Resources Information Center

    Tabb, Winston; Birdsall, William F.

    2002-01-01

    Includes two reports: one from the International Federation of Library Associations and Institutions (IFLA) that discusses digital libraries, standards, collaboration, and membership and structure of IFLA; and one that considers Canadian-American librarianship in the 21st century, including federal government policy, copyright reform, and…

  19. Library Research and Statistics.

    ERIC Educational Resources Information Center

    Lynch, Mary Jo; Brier, David J.; Lebbin, Vickery K.; Halstead, Kent; Fox, Bette-Lee; Kremen, Maya L.; Miller, Marilyn L.; Shontz, Marilyn L.

    1998-01-01

    Provides nine articles: research on libraries and librarianship, 1997; changing faces of library education (ALA-accredited graduate program title changes); number of libraries in the U.S., Canada, and Mexico; highlights of NCES surveys; library acquisition expenditures; price indexes for public and academic libraries; state rankings of selected…

  20. Privatizing Libraries

    ERIC Educational Resources Information Center

    Jerrard, Jane; Bolt, Nancy; Strege, Karen

    2012-01-01

    This timely special report from ALA Editions provides a succinct but comprehensive overview of the "privatization" of public libraries. It provides a history of the trend of local and state governments privatizing public services and assets, and then examines the history of public library privatization right up to the California legislation…

  1. The African-American Mosaic. A Library of Congress Resource Guide for the Study of Black History and Culture.

    ERIC Educational Resources Information Center

    Ham, Debra Newman, Ed.; And Others

    This book presents a broad survey of the Library of Congress's holdings concerning the history and culture of black Americans in the United States. It provides titles of bibliographies, other guides, aids to finding materials, and individual items. This guide, which is arranged chronologically, discusses Library of Congress collections in three…

  2. Japanese Manga in Translation and American Graphic Novels: A Preliminary Examination of the Collections in 44 Academic Libraries

    ERIC Educational Resources Information Center

    Masuchika, Glenn; Boldt, Gail

    2010-01-01

    American graphic novels are increasingly recognized as high-quality literature and an interesting genre for academic study. Graphic novels of Japan, called manga, have established a strong foothold in American culture. This preliminary survey of 44 United States university libraries demonstrates that Japanese manga in translation are consistently…

  3. American Medical Literary Firsts, 1700-1820, in the Countway Library

    PubMed Central

    Cantu, Jane Q.

    1966-01-01

    A combination of two major collections, those of the Harvard Medical and the Boston Medical Libraries, took place at a formal dedication of the Francis A. Countway Library of Medicine in May of 1965. As a result of this unification the historian may now consult many significant primary source materials in one research collection in Boston. Many of these works are early imprints of medical Americana. This paper discusses twenty-four imprints, from 1700 to 1820, which were firsts of their kind in American medical literature. Presented are the first American medical publication, book, pharmacopeia, mortality statistics, anatomical illustrations, transactions of a medical society, medical journal, textbook of obstetrics, medical dictionary, textbook of medicine, and official pharmacopeia. Also discussed are the first works in this country on smallpox inoculation, scarlet fever, pleurisy, public health, medical education, medical ethics, the history of medicine, surgery, epidemiology, smallpox vaccination, dentistry, meningitis, and psychiatry. An exhibit of these items in the Countway Library is planned for the spring and summer of 1966. PMID:5901363

  4. Library+

    ERIC Educational Resources Information Center

    Merrill, Alex

    2011-01-01

    This article discusses possible future directions for academic libraries in the post Web/Library 2.0 world. These possible directions include areas such as data literacy, linked data sets, and opportunities for libraries in support of digital humanities. The author provides a brief sketch of the background information regarding the topics and…

  5. Standards for Library Services for the Blind and Visually Handicapped. Adopted July 14, 1966, by the Library Administration Division, American Library Association.

    ERIC Educational Resources Information Center

    National Accreditation Council for Agencies Serving the Blind and Visually Handicapped, New York, NY.

    Standards and principles for library facilities, programs and equipment services for the visually handicapped are outlined. The duties of federal, state, regional and community libraries are overviewed. Large library and school library requirements are defined along with data on library materials, personnel and equipment needs. Appendices contain…

  6. Recommendations for responsible monitoring and regulation of clinical software systems. American Medical Informatics Association, Computer-based Patient Record Institute, Medical Library Association, Association of Academic Health Science Libraries, American Health Information Management Association, American Nurses Association.

    PubMed

    Miller, R A; Gardner, R M

    1997-01-01

    In mid-1996, the FDA called for discussions on regulation of clinical software programs as medical devices. In response, a consortium of organizations dedicated to improving health care through information technology has developed recommendations for the responsible regulation and monitoring of clinical software systems by users, vendors, and regulatory agencies. Organizations assisting in development of recommendations, or endorsing the consortium position include the American Medical Informatics Association, the Computer-based Patient Record Institute, the Medical Library Association, the Association of Academic Health Sciences Libraries, the American Health Information Management Association, the American Nurses Association, the Center for Healthcare Information Management, and the American College of Physicians. The consortium proposes four categories of clinical system risks and four classes of measured monitoring and regulatory actions that can be applied strategically based on the level of risk in a given setting. The consortium recommends local oversight of clinical software systems, and adoption by healthcare information system developers of a code of good business practices. Budgetary and other constraints limit the type and number of systems that the FDA can regulate effectively. FDA regulation should exempt most clinical software systems and focus on those systems posing highest clinical risk, with limited opportunities for competent human intervention. PMID:9391932

  7. American Zoological Park Libraries and Archives: Historical Considerations and Their Current Status.

    ERIC Educational Resources Information Center

    Kisling, Vernon N., Jr.

    1988-01-01

    Describes the historical development and current status of U.S. zoological libraries, based on information received from 78 libraries and 32 archive collections. Topics discussed include current library collections, management, and services; establishment of libraries; library staffing; library facilities; budgets; and users served by the…

  8. On Research Libraries: Statement and Recommendations of the Committee on Research Libraries of the American Council of Learned Societies, Submitted to National Advisory Commission on Libraries.

    ERIC Educational Resources Information Center

    Burkhardt, Frederick

    This report on the needs of research libraries with recommendations for improvement is based on minutes of meetings of the Committee on Research Libraries and commissioned papers on topics of major concern. Problems of research libraries involve: (1) increased demands because of rising university population, new business and industrial information…

  9. Seminar on the Acquisition of Latin American Library Materials (13th, Lawrence, Kansas, June 20-22, 1968). Final Report and Working Papers. Vol. II.

    ERIC Educational Resources Information Center

    Jordan, Alma; Rovira, Carmen

    The eight working papers used as documentation for the Thirteenth Seminar are included in volume II. They are: (1) "Progress Report on the Seminars on the Acquisition of Latin American Library Materials, 1968;" (2) "Significant Acquisitions of Latin American Material by U.S. Libraries, 1967/68;" (3) "A Report of Bibliographic Activities,…

  10. Seminar on the Acquisition of Latin American Library Materials (15th, Toronto, Ontario, Canada, June 23-26, 1970). Final Report and Working Papers, Volume II.

    ERIC Educational Resources Information Center

    Benson, Susan Shattuck: Bresie, Mayellen

    Volume 2 contains 13 working papers from the 15th Seminar on Acquisition of Latin American Library Materials. The papers are: (1) A Report on Bibliographic Activities; (2) Microfilm Projects Newsletter; (3) Role of Latin American Legal Material in the Social Science Research Library; (4) A description of sources for Legal and Social Science…

  11. Identification of Information Needs of the American Indian Community That Can Be Met by Library Services. Evaluation Report.

    ERIC Educational Resources Information Center

    National Indian Education Association, Minneapolis, Minn.

    The National Indian Education Association operated a research and demonstration project to provide library and information services to three American Indian reservations over a period of four years. Attempts were made to determine what kinds of information services the people themselves wanted, and then a program was developed to meet these needs.…

  12. The Common Core: A Disaster for Libraries, a Disaster for Language Arts, a Disaster for American Education

    ERIC Educational Resources Information Center

    Krashen, Stephen

    2014-01-01

    This author contends that there never has been a need for the Common Core State Standards (CCSS), and there is no evidence that it will do students any good. The Common Core ignores the real problem in American education: poverty. The Common Core movement will be a disaster for libraries and will have a negative impact on nearly every aspect of…

  13. Communication in the Service of American Health...A Bicentennial Report from the National Library of Medicine.

    ERIC Educational Resources Information Center

    National Library of Medicine (DHEW), Bethesda, MD.

    Programs of the National Library of Medicine over almost a century and a half are described, ranging from a history of American medical literature and the development of medical indexing to modern technological developments. Activities covered include the development of the Toxicology Information Program and the online data base TOXLINE; the…

  14. Culture Keepers III: Making Global Connections. Proceedings of the Black Caucus of the American Library Association (BCALA) National Conference of African American Librarians (3rd, Winston-Salem, North Carolina, July 31-August 3, 1997).

    ERIC Educational Resources Information Center

    Neely, Teresa Y., Ed.

    The 49 papers presented in this volume are evidence of the research, scholarship, and professional nature of the offerings of the third National Conference of African American Librarians, sponsored by the Black Caucus of the American Library Association. The papers are arranged into nine tracks and Pre-Conference topics: I: Library Connections: An…

  15. National Association and Organization Reports. American Library Association; Association of American Publishers; American Booksellers Association; Association of Research Libraries; Scholarly Publishing and Academic Resources Coalition (SPARC); Council on Library and Information Resources.

    ERIC Educational Resources Information Center

    Freedman, Maurice J.; Platt, Judith; Hoynes, Michael; Webster, Duane E.; Johnson, Richard; Smith, Kathlin

    2003-01-01

    Includes six reports from national associations and organizations. Highlights include annual meetings; government affairs; copyright; administration; diversity; new technologies; international programs; scholarly communication; information policy; access to information; preservation; statistics and measurement; digital libraries; economics of…

  16. ALA Statement on Cable Telecommunications Act of 1982.

    ERIC Educational Resources Information Center

    Cooke, Eileen D.

    1982-01-01

    Presents views of the American Library Association on the Cable Telecommunications Act of 1982, providing a brief overview of library involvement in cable television and endorsing amendments suggested by the National Federation of Local Cable Programmers. (EJS)

  17. Playing in the Past: A History of Games, Toys, and Puzzles in North American Libraries

    ERIC Educational Resources Information Center

    Nicholson, Scott

    2013-01-01

    Games and other forms of play are used in today's libraries to attract underserved patrons, to introduce patrons to other library resources and services, and to facilitate engagement between library patrons. While many perceive gaming as a new library service, gaming services have been part of librarianship since the nineteenth century…

  18. Discover Space: an IYA program for libraries

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.

    2009-12-01

    Across the country, there is a growing concern regarding the number of students entering science and technology careers. While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement. This is particularly true when family interactions are factored in. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. The nation’s more than 17,000 public libraries attract diverse audiences in almost every community. Science exhibits in libraries could potentially reach many adults and upper elementary and middle school students with STEM content. The Space Science Institute (SSI) is partnering with the American Library Association (ALA) to develop a pilot exhibit called Discover Space. The exhibit includes two areas: Space Storms and Star Quest and is currently on tour in Colorado. It is a featured IYA outreach project from SSI. This presentation will focus on the results of a national survey of libraries that SSI and ALA conducted in 2008 about interest in STEM exhibits as well as the development process that was used to design and fabricate the exhibit. Preliminary evaluation results will also be shared. The presentation will conclude with an examination of how this program could benefit underserved communities around the country.

  19. A Comparative Study of the Administration of the Government Documents Sections of the National Archives of the United States, the National Library of Canada, Selected American State Archives and Libraries.

    ERIC Educational Resources Information Center

    Freeman, Nola A.

    This report, written for a National Archives Staff training program, presents the results of a survey which sought information about the administration of the government documents sections of the National Library of Canada, the National Archives of the United States, and 12 selected American state archives and state libraries. The survey gathered…

  20. Building the Virtual Reference Desk in a 24/7 World. OCLC/Library of Congress Symposium at ALA Midwinter 2001 (Washington, DC, January 12, 2001). Tape 1 [and] Tape 2. [Videotapes].

    ERIC Educational Resources Information Center

    Library of Congress, Washington, DC.

    With the emergence of Web help services, libraries are no longer the lone providers of information. Today's researchers need to find quickly information that is usable, relevant, authoritative, and verifiable. To meet that need, libraries must adapt traditional strengths of acquiring, describing, and serving information to an environment that is…

  1. Collaborating with Public Libraries: Successes, Challenges, and Thoughts for the Future

    NASA Astrophysics Data System (ADS)

    Smith, D. A.; Eisenhamer, B.; Sharma, M.; Brandehoff, S.; Dominiak, J.; Shipp, S.; LaConte, K.

    2012-08-01

    Public libraries serve learners of all ages and backgrounds, provide free and convenient access to resources, and have strong ties to local schools and community-based organizations. Libraries recognize the importance of science literacy to our culture and strive increasingly to include science in their programming portfolio. What are our shared goals in communicating science to the public? What resources, events, or programs are available through your local public library? How can we work with public libraries to connect people to science? This interactive Special Interest Group discussion facilitated by representatives from the American Library Association's (ALA) Public Programs Office, the Lunar and Planetary Institute's Explore! program, and the Space Telescope Science Institute's Visions of the Universe: Four Centuries of Discovery library exhibit explored successes, lessons learned, and future opportunities for incorporating science programming into public library settings.

  2. LibTech Highlights from ALA Midwinter

    ERIC Educational Resources Information Center

    Hane, Paula J.

    2009-01-01

    Despite lower attendance than in the past and blustery, cold weather, the American Library Association's Midwinter Meeting in Denver in January offered lots of news from industry vendors and lots of opportunities to discuss important issues and trends. In this report, the author highlights some of the most important product announcements with a…

  3. ALA in Miami Beach: Summer Bummer.

    ERIC Educational Resources Information Center

    Annichiarico, Mark; And Others

    1994-01-01

    Provides an overview of the 1994 American Library Association Convention. Highlights include problems with the location; teen violence; federal legislation; awards; speakers; gender issues and technology, including video games and the Internet; intellectual freedom; multiculturalism and librarian recruitment; CD-ROM; and exhibits. (LRW)

  4. An Historical Survey of the Relation Among the Philosophy, Method, and Libraries of American Theological Education.

    ERIC Educational Resources Information Center

    Hamm, G. Paul

    This dissertation is the report of an analysis of the literature of American theological education. American theological education is defined here as the efforts of American Protestant theological schools, particularly the member schools of the American Association of Theological Schools (AATS), to prepare students for ministry. An assumption of…

  5. Trends and Innovations in North American Libraries with an Emphasis on Developments in Canada, Especially Ontario. A Course Outline and Bibliographies.

    ERIC Educational Resources Information Center

    Palmer, Joseph W.

    This outline for a graduate library school course at the State University of New York at Buffalo emphasizes trends and developments in North American librarianship with primary emphasis on Canada (especially Ontario). The participation of Canadian authorities as guest lecturers and field trips to Canadian libraries are important elements in the…

  6. Data Comparability and Public Policy: New Interest in Public Library Data. Papers Presented at Meetings of the American Statistical Association. Working Paper Series.

    ERIC Educational Resources Information Center

    National Center for Education Statistics (ED), Washington, DC.

    The four papers contained in this volume were presented at the August 1994 meetings of the American Statistical Association as a session titled, "Public Policy and Data Comparability: New Interest in Public Library Data." The first paper, "Public Library Statistics: Two Systems Compared" (Mary Jo Lynch), describes two systems that collect data on…

  7. Job Opportunities for Public Library Directors: An Analysis of Job Postings Appearing in "American Libraries" and "Library Journal," November 1995-November 1996.

    ERIC Educational Resources Information Center

    Knapik, Michelle

    This study examined: the position of the public library director as related to salary; benefits; geographic location of openings; academic education and degrees; professional, administrative and technological experience; professional contribution; and salaries compared to geographic location and education. The postings analyzed were from "American…

  8. Delta-ALA urine test

    MedlinePlus

    ... increased level of urinary delta-ALA may indicate: Lead poisoning Porphyria (several types) A decreased level may occur ... A.M. Editorial team. Related MedlinePlus Health Topics Lead Poisoning Porphyria Browse the Encyclopedia A.D.A.M., ...

  9. Sunset at the ALaMO

    NASA Video Gallery

    A new color all-sky camera has opened its eyes at the ALaMO, or Automated Lunar and Meteor Observatory, at NASA's Marshall Space Flight Center in Huntsville, Ala. Watch its inaugural video below, s...

  10. The American Museum of Natural History Mineral Library for Spectroscopic Standards

    NASA Astrophysics Data System (ADS)

    Nissinboim, A.; Ebel, D. S.; Harlow, G. E.; Boesenberg, J. S.; Sherman, K. M.; Lewis, E. R.; Brusentsova, T. N.; Peale, R. E.; Lisse, C. M.; Hibbitts, C. A.

    2010-03-01

    Minerals from the AMNH collections are highly characterized (crystal XRD, EMPA), powdered <2 µm, reanalyzed (SEM, powder XRD), and transmission IR spectra analyzed for Herschel PACS. Library minerals will also serve reflectance spectra needs.

  11. Results from Five Task Forces Appointed by the American Council of Learned Societies and the Council on Library and Information Resources. Scholarship, Instruction, and Libraries at the Turn of the Century.

    ERIC Educational Resources Information Center

    Council on Library and Information Resources, Washington, DC.

    The American Council of Learned Societies and the Council on Library and Information Resources appointed 36 scholars, librarians, and leaders of various academic enterprises to five task forces "to consider changes in the process of scholarship and instruction that will result from the use of digital technology and to make recommendations to…

  12. Marketing the Virtual Library

    ERIC Educational Resources Information Center

    Fagan, Jody Condit

    2009-01-01

    Far more people are familiar with their local public or college library facility than their library's website and online resources. In fact, according to a recent survey, 96% of Americans said they had visited a library in person, but less than one-third have visited their online library. Since everyone agrees that online library resources are…

  13. The National Library of Medicine and the American medical information system: the physician's perspective.

    PubMed Central

    Davies, N E

    1986-01-01

    During the past 150 years an excellent health sciences information system has been developed in the United States. Led by the National Library of Medicine (NLM), the system grew along traditional lines until after World War II, when medical researchers, educators, and practitioners produced an enormous amount of new information. To cope with this growth, the power of computers joined traditional librarianship and MEDLARS was born. In 1965 Congress passed the Medical Library Assistance Act, which enabled NLM to lead the nation's and the world's health sciences professionals into the Information Age. Much as been accomplished by NLM, yet much remains to be done to make health information available cheaply, easily, and quickly to all who need it. PMID:3779169

  14. Opportunity for All: How the American Public Benefits from Internet Access at U.S. Libraries

    ERIC Educational Resources Information Center

    Becker, Samantha; Crandall, Michael D.; Fisher, Karen E.; Kinney, Bo; Landry, Carol; Rocha, Anita

    2010-01-01

    Over the past decade and a half, free access to computers and the Internet in U.S. public libraries evolved from a rare commodity into a core service. Now, people from all walks of life rely on this service every day to look for jobs, find health care, and read the latest news. As the nation struggled through a historic recession, nearly one-third…

  15. Library collaboration with medical humanities in an american medical college in qatar.

    PubMed

    Birch, Sally; Magid, Amani; Weber, Alan

    2013-11-01

    The medical humanities, a cross-disciplinary field of practice and research that includes medicine, literature, art, history, philosophy, and sociology, is being increasingly incorporated into medical school curricula internationally. Medical humanities courses in Writing, Literature, Medical Ethics and History can teach physicians-in-training communication skills, doctor-patient relations, and medical ethics, as well as empathy and cross-cultural understanding. In addition to providing educational breadth and variety, the medical humanities can also play a practical role in teaching critical/analytical skills. These skills are utilized in differential diagnosis and problem-based learning, as well as in developing written and oral communications. Communication skills are a required medical competency for passing medical board exams in the U.S., Canada, the UK and elsewhere. The medical library is an integral part of medical humanities training efforts. This contribution provides a case study of the Distributed eLibrary at the Weill Cornell Medical College in Qatar in Doha, and its collaboration with the Writing Program in the Premedical Program to teach and develop the medical humanities. Programs and initiatives of the DeLib library include: developing an information literacy course, course guides for specific courses, the 100 Classic Books Project, collection development of 'doctors' stories' related to the practice of medicine (including medically-oriented movies and TV programs), and workshops to teach the analytical and critical thinking skills that form the basis of humanistic approaches to knowledge. This paper outlines a 'best practices' approach to developing the medical humanities in collaboration among the medical library, faculty and administrative stakeholders. PMID:24223240

  16. Library Collaboration with Medical Humanities in an American Medical College in Qatar

    PubMed Central

    Birch, Sally; Magid, Amani; Weber, Alan

    2013-01-01

    The medical humanities, a cross-disciplinary field of practice and research that includes medicine, literature, art, history, philosophy, and sociology, is being increasingly incorporated into medical school curricula internationally. Medical humanities courses in Writing, Literature, Medical Ethics and History can teach physicians-in-training communication skills, doctor-patient relations, and medical ethics, as well as empathy and cross-cultural understanding. In addition to providing educational breadth and variety, the medical humanities can also play a practical role in teaching critical/analytical skills. These skills are utilized in differential diagnosis and problem-based learning, as well as in developing written and oral communications. Communication skills are a required medical competency for passing medical board exams in the U.S., Canada, the UK and elsewhere. The medical library is an integral part of medical humanities training efforts. This contribution provides a case study of the Distributed eLibrary at the Weill Cornell Medical College in Qatar in Doha, and its collaboration with the Writing Program in the Premedical Program to teach and develop the medical humanities. Programs and initiatives of the DeLib library include: developing an information literacy course, course guides for specific courses, the 100 Classic Books Project, collection development of ‘doctors’ stories’ related to the practice of medicine (including medically-oriented movies and TV programs), and workshops to teach the analytical and critical thinking skills that form the basis of humanistic approaches to knowledge. This paper outlines a ‘best practices’ approach to developing the medical humanities in collaboration among the medical library, faculty and administrative stakeholders. PMID:24223240

  17. From Doctoral Dissertation to Publication: A Study of 1995 American Graduates in Library and Information Sciences

    ERIC Educational Resources Information Center

    Anwar, Mumtaz A.

    2004-01-01

    This article examines the publishing activity of 54 individuals who received their doctoral degrees from American universities in 1995 and the publications that were derived from their dissertations. Publication data covered two five-year periods, 1991-1995 research-in-progress and 1996-2000 postdoctoral period. One third of the graduates did not…

  18. Los Angeles County Public Library Ethnic Resource Centers: The American Indian Resource Center; Asian Pacific Resource Center; Black Resource Center; Chicano Resource Center.

    ERIC Educational Resources Information Center

    Los Angeles County Public Library, CA.

    Descriptions of the information and cultural resource centers established by the Los Angeles County (California) Public Library to serve four ethnic populations--American Indians, Asian Pacifics, Blacks, and Chicanos--are presented in this document. Information provided for each individual center includes its history, policies, collection,…

  19. Seminar on the Acquisition of Latin American Library Materials (15th, Toronto, Ontario, Canada, June 23-26, 1970). Final Report and Working Papers, Volume I.

    ERIC Educational Resources Information Center

    Benson, Susan Shattuck; Bresie, Mayellen

    Volume 1 of the 15th Seminar on Acquisition of Latin American Library Materials contains: (1) Summary Reports for Sessions 1 through 6; (2) Program of the 15th Seminar; (3) Resolutions of the 15th Seminar; (4) Participants in the 15th Seminar; (5) Seminar Committees, 1970-1971; (6) List of Working Papers; (7) Working paper number one -- Progress…

  20. Library Instruction 2.0

    ERIC Educational Resources Information Center

    Bridgewater, Rachel; Deitering, Anne-Marie; Munro, Karen

    2009-01-01

    At the 2008 ALA Annual Conference, a wonderful Association of College and Research Libraries (ACRL) preconference was presented entitled "Library Instruction 2.0: Building Your Online Instruction Toolkit". The presentation was enlightening and provided numerous and valuable recommendations for Web 2.0 sites that can facilitate and enliven library…

  1. Exploring the Core: An Examination of Required Courses in ALA-Accredited

    ERIC Educational Resources Information Center

    Hall, Russell A.

    2009-01-01

    This paper examines the required courses of ALA-accredited Library and Information Science programs as published on their websites. The study expands on previous research in this area. Findings show that the typical core curriculum has grown to include both research and information technology in addition to the more traditional subjects. The…

  2. Comparison between mALA- and ALA-PDT in the treatment of basal cell carcinomas

    NASA Astrophysics Data System (ADS)

    Schleier, Peter; Zenk, Witold; Hyckel, Peter; Berndt, Alexander

    2006-02-01

    Introduction: The external application of aminoleavulinic acid (ALA), which is a substrate of physiologic cell metabolism, represents a possible treatment option in superficial basal cell carcinomas (BCC). The development of new ALA-esters (mALA) with potential for higher penetration depths promises higher therapeutic success. This research aimed to prove the following hypothesis: The cytotoxic effect of the mALA- photodynamic therapy (mALA-PDT), when compared to the ALA-PDT, leads to a higher clinical success rate. Material and Methods: 24 patients with multiple facial tumors, after having received several local surgical excisions with known histology, were treated with either ALA- or mALA-PDT, during the past two years. In total, 89 basal cell carcinoma, 45 actinic keratoses, 6 keratoacanthoma, and 2 squamous cell carcinomas were treated. ALA-PDT: A thermo gel with 40 % mALA or ALA was applied from a cooled syringe. Three to five hours after gel application the skin was cleaned from any gel residues. Irradiation was done with a diode laser and was performed in two sessions, each 10 min long. After intervals of 2, 4 and 12 weeks, the patients were recalled to assess therapeutic efficacy. This was followed by photographic documentation. Results: More than 80% of the tumors treated primarily were resolved successfully. A recurrence rate of approximately 15% was observed. Three per cent of the tumors showed no reaction to therapy. There were no statistically significant differences between the two therapeutic groups. Discussion: The advantage of the use of ALA lies foremost in the fast metabolic use of the body's own photosensitizer PpIX. There are no known side effects of this therapy. Moreover, external application is superior to systemic application with regard to patient management. The method can be combined with other therapies. Although the mALA should have a better penetration in tumor tissue, the therapeutic outcome is similar to the use of ALA.

  3. PDT of the endometrium using ALA

    NASA Astrophysics Data System (ADS)

    Gannon, Michael J.; Vernon, David I.; Holroyd, J. Andrew; Stringer, Mark R.; Johnson, Nick; Brown, Stanley B.

    1997-05-01

    There is a widely recognized need for new approaches to effect endometrial ablation as an alternative to hysterectomy for treatment of menorrhagia. Photodynamic therapy (PDT) offers one such approach. We have investigated the use of 5-aminolaevulinic acid (ALA)-based PDT of the endometrium in model systems and in a series of patients. In all of this work, the ALA was administrated directly into the uterine cavity to reduce any possibility of systemic photosensitization. In a series of experiments in perfused ex vivo uteri, ALA was introduced into the cavity and protoporphyrin formation was measured in the endometrium, the underlying myometrium and the perfusate. ALA transfer into the perfusate was also measured. This work demonstrated that protoporphyrin formation in the endometrium was approximately ten fold that in the underlying myometrium and that systemic photosensitization would be unlikely to result form transfer of administered ALA from the uterus into the circulation. Similar results were found in studies carried out in vivo, where ALA was administered to patients scheduled for hysterectomy. Using a specially designed light source, the first patients have now been treated by giving intrauterine ALA followed by laser light. Two series of treatments - 10 in all - have been carried out. Eight patients have one year follow up. A reduction in measured menstrual blood loss was demonstrated in all but one patient. Complete symptomatic relief was obtained in tow women who did not require further treatment.

  4. Organizations Contributing to Development of Library Standards.

    ERIC Educational Resources Information Center

    Avram, Henriette D.; And Others

    1982-01-01

    Describes a variety of institutions and groups that affect promulgation of library standards, including standards organizations (American National Standards Institute, International Organization for Standardization); library associations (American Library Association); national and international committees, government agencies (National Bureau of…

  5. ALA Meets at Ground-Zero, New York City Conference Report.

    ERIC Educational Resources Information Center

    Wilson Library Bulletin, 1986

    1986-01-01

    Description of 1986 American Library Association Conference summarizes significant organizational actions and presentations on upgrading automation systems, censorship, federal libraries, fees and public library services, black community information needs, Linked Systems Project, libraries and the homeless, new products exhibited, and 1994…

  6. A DNA Barcode Library for North American Ephemeroptera: Progress and Prospects

    PubMed Central

    Webb, Jeffrey M.; Jacobus, Luke M.; Funk, David H.; Zhou, Xin; Kondratieff, Boris; Geraci, Christy J.; DeWalt, R. Edward; Baird, Donald J.; Richard, Barton; Phillips, Iain; Hebert, Paul D. N.

    2012-01-01

    DNA barcoding of aquatic macroinvertebrates holds much promise as a tool for taxonomic research and for providing the reliable identifications needed for water quality assessment programs. A prerequisite for identification using barcodes is a reliable reference library. We gathered 4165 sequences from the barcode region of the mitochondrial cytochrome c oxidase subunit I gene representing 264 nominal and 90 provisional species of mayflies (Insecta: Ephemeroptera) from Canada, Mexico, and the United States. No species shared barcode sequences and all can be identified with barcodes with the possible exception of some Caenis. Minimum interspecific distances ranged from 0.3–24.7% (mean: 12.5%), while the average intraspecific divergence was 1.97%. The latter value was inflated by the presence of very high divergences in some taxa. In fact, nearly 20% of the species included two or three haplotype clusters showing greater than 5.0% sequence divergence and some values are as high as 26.7%. Many of the species with high divergences are polyphyletic and likely represent species complexes. Indeed, many of these polyphyletic species have numerous synonyms and individuals in some barcode clusters show morphological attributes characteristic of the synonymized species. In light of our findings, it is imperative that type or topotype specimens be sequenced to correctly associate barcode clusters with morphological species concepts and to determine the status of currently synonymized species. PMID:22666447

  7. Phonological activation in anaphoric lexical access (ALA).

    PubMed

    Simner, J; Smyth, R

    Simner and Smyth (1998) propose that anaphoric lexical access (ALA) occurs at an anaphor and targets the lexical entry (specifically, the lemma) of the antecedent. Since the word frequency effect (e.g., Rubenstein et al., 1970) resides at the lexeme (Jescheniak & Levelt, 1994) Simner and Smyth predict, and subsequently illustrate, that ALA exhibits no frequency effect. A problem arises, however: if ALA does not access the lexeme, how do we account for phonological priming at anaphor sites (e.g., Tanenhaus et al., 1985)? We claim that this is the result of "incidental" lemma-to-lexeme activation. Furthermore, we argue that since lexeme activation is not crucial to anaphor comprehension, anaphor reading times indicate lemma search times only (therefore there is no frequency effect). An experiment is presented demonstrating that lemma-access during ALA can cause incidental lexeme activation without invoking a frequency effect. PMID:10433737

  8. Asian American Women: A Bibliography.

    ERIC Educational Resources Information Center

    Yung, Judy, Comp.; And Others

    1978-01-01

    Listed in this bibliography are materials available on Asian American women at the Asian Community Library (Oakland Public Library) and the Asian American Studies Library (University of California, Berkeley). (Author/EB)

  9. Statistics & Input-Output Measures for Colorado Public Libraries, 1997.

    ERIC Educational Resources Information Center

    Seidl, Ann M.

    This document contains statistics and input-output measures for all Colorado public libraries. Tables of the following 1997 survey data are provided: state totals and averages; public library addresses; telephone, fax, and URL for public libraries; public library directors; borrowers, outlets and bookmobiles; ALA-MLS librarians, other staff and…

  10. STAR Library Education Network: a hands-on learning program for libraries and their communities

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.

    2010-12-01

    Science and technology are widely recognized as major drivers of innovation and industry (e.g. Rising above the Gathering Storm, 2006). While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement and public understanding of STEM disciplines. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. Designed spaces, like libraries, allow lifelong, life-wide, and life-deep learning to take place though the research basis for learning in libraries is not as developed as other informal settings like science centers. The Space Science Institute’s National Center for Interactive Learning (NCIL) in partnership with the American Library Association (ALA), the Lunar and Planetary Institute (LPI), and the National Girls Collaborative Project (NGCP) have received funding from NSF to develop a national education project called the STAR Library Education Network: a hands-on learning program for libraries and their communities (or STAR-Net for short). STAR stands for Science-Technology, Activities and Resources. The overarching goal of the project is to reach underserved youth and their families with informal STEM learning experiences. This project will deepen our knowledge of informal/lifelong learning that takes place in libraries and establish a learning model that can be compared to the more established free-choice learning model for science centers and museums. The project includes the development of two STEM hands-on exhibits on topics that are of interest to library staff and their patrons: Discover Earth and Discover Tech. In addition, the project will produce resources and inquiry-based activities that libraries can use to enrich the exhibit experience. Additional resources will be provided through partnerships with relevant

  11. Library School Faculty Member Perceptions Regarding Faculty Status for Academic Librarians

    ERIC Educational Resources Information Center

    Wyss, Paul Alan

    2010-01-01

    The faculties of the library schools listed as ALA-accredited are directly involved in setting the direction of the education provided to academic librarians through curriculum development and teaching. The curricula and teaching at ALA-accredited library schools revolve around aspects of librarianship such as providing research assistance at a…

  12. ALA-Butyrate prodrugs for Photo-Dynamic Therapy

    NASA Astrophysics Data System (ADS)

    Berkovitch, G.; Nudelman, A.; Ehenberg, B.; Rephaeli, A.; Malik, Z.

    2010-05-01

    The use of 5-aminolevulinic acid (ALA) administration has led to many applications of photodynamic therapy (PDT) in cancer. However, the hydrophilic nature of ALA limits its ability to penetrate the cells and tissues, and therefore the need for ALA derivatives became an urgent research target. In this study we investigated the activity of novel multifunctional acyloxyalkyl ester prodrugs of ALA that upon metabolic hydrolysis release active components such as, formaldehyde, and the histone deacetylase inhibitory moiety, butyric acid. Evaluation of these prodrugs under photo-irradiation conditions showed that butyryloxyethyl 5-amino-4-oxopentanoate (ALA-BAC) generated the most efficient photodynamic destruction compared to ALA. ALA-BAC stimulated a rapid biosynthesis of protoporphyrin IX (PpIX) in human glioblastoma U-251 cells which resulted in generation of intracellular ROS, reduction of mitochondrial activity, leading to apoptotic and necrotic death of the cells. The apoptotic cell death induced by ALA / ALA-BAC followed by PDT equally activate intrinsic and extrinsic apoptotic signals and both pathways may occur simultaneously. The main advantage of ALA-BAC over ALA stems from its ability to induce photo-damage at a significantly lower dose than ALA.

  13. Bibliographic Instruction in Afro-American History: Selected Sources and the Use of "Library of Congress Subject Headings."

    ERIC Educational Resources Information Center

    Geary, James W.

    This document was developed primarily in response to a bibliographic lecture in an upper-division Afro-American survey course that covers the American colonial period to the present. In addition to representative examples of reference works, bibliographies, bibliographic sources, and periodical indexes, a section is devoted to the proper use of…

  14. Library Guide for International Students.

    ERIC Educational Resources Information Center

    Rutgers, The State Univ., New Brunswick, NJ. Univ. Libraries.

    This guide to Rutgers University Libraries (RUL) is intended as an introduction to the library system for foreign students studying at the University. The guide consists of the following: welcoming remarks; a brief discussion of the American academic library systems; a list of the locations and abbreviations of the 25 libraries, collections and…

  15. Libraries in Alabama: MedlinePlus

    MedlinePlus

    ... this page: https://medlineplus.gov/libraries/alabama.html Libraries in Alabama To use the sharing features on ... JavaScript. Birmingham American Sports Medicine Institute Sports Medicine LIBRARY 833 St. Vincent's Drive Suite 205 Birmingham, AL ...

  16. Morphological Versatility in the Self-Assembly of Val-Ala and Ala-Val Dipeptides.

    PubMed

    Erdogan, Hakan; Babur, Esra; Yilmaz, Mehmet; Candas, Elif; Gordesel, Merve; Dede, Yavuz; Oren, Ersin Emre; Demirel, Gokcen Birlik; Ozturk, Mustafa Kemal; Yavuz, Mustafa Selman; Demirel, Gokhan

    2015-07-01

    Since the discovery of dipeptide self-assembly, diphenylalanine (Phe-Phe)-based dipeptides have been widely investigated in a variety of fields. Although various supramolecular Phe-Phe-based structures including tubes, vesicles, fibrils, sheets, necklaces, flakes, ribbons, and wires have been demonstrated by manipulating the external physical or chemical conditions applied, studies of the morphological diversity of dipeptides other than Phe-Phe are still required to understand both how these small molecules respond to external conditions such as the type of solvent and how the peptide sequence affects self-assembly and the corresponding molecular structures. In this work, we investigated the self-assembly of valine-alanine (Val-Ala) and alanine-valine (Ala-Val) dipeptides by varying the solvent medium. It was observed that Val-Ala dipeptide molecules may generate unique self-assembly-based morphologies in response to the solvent medium used. Interestingly, when Ala-Val dipeptides were utilized as a peptide source instead of Val-Ala, we observed distinct differences in the final dipeptide structures. We believe that such manipulation may not only provide us with a better understanding of the fundamentals of the dipeptide self-assembly process but also may enable us to generate novel peptide-based materials for various applications. PMID:26086903

  17. ALA Pretreatment Improves Waterlogging Tolerance of Fig Plants

    PubMed Central

    An, Yuyan; Qi, Lin; Wang, Liangju

    2016-01-01

    5-aminolevulinic acid (ALA), a natural and environmentally friendly plant growth regulator, can improve plant tolerance to various environmental stresses. However, whether ALA can improve plant waterlogging tolerance is unknown. Here, we investigated the effects of ALA pretreatment on the waterlogging-induced damage of fig (Ficus carica Linn.) plants, which often suffer from waterlogging stress. ALA pretreatment significantly alleviated stress-induced morphological damage, increased leaf relative water content (RWC), and reduced leaf superoxide anion (O2⋅¯) production rate and malonaldehyde (MDA) content in fig leaves, indicating ALA mitigates waterlogging stress of fig plants. We further demonstrated that ALA pretreatment largely promoted leaf chlorophyll content, photosynthetic electron transfer ability, and photosynthetic performance index, indicating ALA significantly improves plant photosynthetic efficiency under waterlogging stress. Moreover, ALA pretreatment significantly increased activities of leaf superoxide dismutase (SOD) and peroxidase (POD), root vigor, and activities of root alcohol dehydrogenase (ADH), and lactate dehydrogenase (LDH), indicating ALA also significantly improves antioxidant ability and root function of fig plants under waterlogging stress. Taken together, ALA pretreatment improves waterlogging tolerance of fig plants significantly, and the promoted root respiration, leaf photosynthesis, and antioxidant ability may contribute greatly to this improvement. Our data firstly shows that ALA can improve plant waterlogging tolerance. PMID:26789407

  18. ALA Pretreatment Improves Waterlogging Tolerance of Fig Plants.

    PubMed

    An, Yuyan; Qi, Lin; Wang, Liangju

    2016-01-01

    5-aminolevulinic acid (ALA), a natural and environmentally friendly plant growth regulator, can improve plant tolerance to various environmental stresses. However, whether ALA can improve plant waterlogging tolerance is unknown. Here, we investigated the effects of ALA pretreatment on the waterlogging-induced damage of fig (Ficus carica Linn.) plants, which often suffer from waterlogging stress. ALA pretreatment significantly alleviated stress-induced morphological damage, increased leaf relative water content (RWC), and reduced leaf superoxide anion ([Formula: see text]) production rate and malonaldehyde (MDA) content in fig leaves, indicating ALA mitigates waterlogging stress of fig plants. We further demonstrated that ALA pretreatment largely promoted leaf chlorophyll content, photosynthetic electron transfer ability, and photosynthetic performance index, indicating ALA significantly improves plant photosynthetic efficiency under waterlogging stress. Moreover, ALA pretreatment significantly increased activities of leaf superoxide dismutase (SOD) and peroxidase (POD), root vigor, and activities of root alcohol dehydrogenase (ADH), and lactate dehydrogenase (LDH), indicating ALA also significantly improves antioxidant ability and root function of fig plants under waterlogging stress. Taken together, ALA pretreatment improves waterlogging tolerance of fig plants significantly, and the promoted root respiration, leaf photosynthesis, and antioxidant ability may contribute greatly to this improvement. Our data firstly shows that ALA can improve plant waterlogging tolerance. PMID:26789407

  19. American lifelines alliance efforts to improve electric power transmission reliability

    USGS Publications Warehouse

    Nishenko, S.P.; Savage, W.U.; Honegger, D.G.; McLane, T.R.

    2002-01-01

    A study was performed on American Lifelines Alliance (ALA) efforts to improve electric power transmission reliability. ALA is a public-private partnership project, with the goal of reducing risks to lifelines from natural hazards and human threat events. The mechanism used by ALA for developing national guidelines for lifeline systems is dependent upon using existing Standards Developing Organizations (SDO) accredited by the American National Standards Institute (ANSI) as means to achieve national consensus.

  20. Clergy of the Mind: Alvin S. Johnson, William S. Learned, the Carnegie Corporations, and the American Library Association

    ERIC Educational Resources Information Center

    Latham, Joyce M.

    2010-01-01

    During the early twentieth century, Alvin Johnson and William S. Learned produced two separate but related studies relative to the donations of the Carnegie Corporation of New York (CCNY) to public library construction. These reports became means for the planned disassociation of the philanthropic organization from its historical relationship with…

  1. The Relationship between Library Use and Academic Achievement of English and Spanish-Speaking Hispanic American Students

    ERIC Educational Resources Information Center

    Park, Hae Seong; Yau, Jenny

    2014-01-01

    The purpose of this study is to examine the relationship between school library use and academic achievement of Hispanic students. This study utilizes data from the base-year and the first follow-up of the Education Longitudinal Study: 2002/06. A series of hierarchical regression analysis is incorporated to examine the nature of associations among…

  2. Astro4Girls and Their Families: Sharing Science via Public Libraries

    NASA Astrophysics Data System (ADS)

    Sharma, M.; Smith, D.; Eisenhamer, B.; Ryer, H.; Dussault, M.; Braswell, E.; Cominsky, L.; Apple, N.; Della, T.; Whiffen, P.; Harman, P.; Mitchell, S.; Eyermann, S.; Brandehoff, S.; Dominiak, J.

    2013-04-01

    The “Astro4Girls and Their Families” pilot program offered a variety of informal science events at nine public libraries nationwide in conjunction with Women's History Month (March) 2012. The goals were to engage girls and their families in science, by helping them discover the Universe for themselves and celebrating the contribution of women to astronomy and science. We offered a wide range of activities, from using robotic telescopes for “Do-It-Yourself (DIY) astrophotography” to making edible black holes, to exploring the infrared Universe. Our main target audience was middle-school aged girls, but students of all ages, their families and the public were welcome to participate in many of the activities. Five NASA Science Mission Directorate-funded Astrophysics Education and Public Outreach teams partnered with public libraries in this pilot program; each worked with 1 or 2 libraries to offer a total of about 15 events reaching over 300 people in both urban and rural areas. The American Library Association Public Programs Office identified participating libraries and facilitated their participation through its role in the SMD-funded “Visions of the Universe: Four Centuries of Discovery” traveling exhibit. The NASA Astrophysics Science Education and Public Outreach Forum coordinated the collaboration. The website is: http://www.ala.org/programming/astro4girls. This poster outlines the details of planning and implementing the 2012 pilot program, its successes, and lessons learned. The collaborators would like to engage the EPO community in a discussion of how to sustain Astro4Girls and engage additional public libraries nationwide during future Women's History Months.

  3. The Evolution of NxtWave Leaders for 21st-Century Libraries

    ERIC Educational Resources Information Center

    Howard, Jody K.

    2015-01-01

    In January 2012, a group of four school library professors attending the ALA Midwinter Meeting were having lunch and discussing various issues related to the school library field. These school library professors agreed that one challenge facing the profession is preparing future leaders. As current school library leaders retire, it is difficult to…

  4. First DNA Barcode Reference Library for the Identification of South American Freshwater Fish from the Lower Paraná River.

    PubMed

    Díaz, Juan; Villanova, Gabriela Vanina; Brancolini, Florencia; Del Pazo, Felipe; Posner, Victoria Maria; Grimberg, Alexis; Arranz, Silvia Eda

    2016-01-01

    Valid fish species identification is essential for biodiversity conservation and fisheries management. Here, we provide a sequence reference library based on mitochondrial cytochrome c oxidase subunit I for a valid identification of 79 freshwater fish species from the Lower Paraná River. Neighbour-joining analysis based on K2P genetic distances formed non-overlapping clusters for almost all species with a ≥99% bootstrap support each. Identification was successful for 97.8% of species as the minimum genetic distance to the nearest neighbour exceeded the maximum intraspecific distance in all these cases. A barcoding gap of 2.5% was apparent for the whole data set with the exception of four cases. Within-species distances ranged from 0.00% to 7.59%, while interspecific distances varied between 4.06% and 19.98%, without considering Odontesthes species with a minimum genetic distance of 0%. Sequence library validation was performed by applying BOLDs BIN analysis tool, Poisson Tree Processes model and Automatic Barcode Gap Discovery, along with a reliable taxonomic assignment by experts. Exhaustive revision of vouchers was performed when a conflicting assignment was detected after sequence analysis and BIN discordance evaluation. Thus, the sequence library presented here can be confidently used as a benchmark for identification of half of the fish species recorded for the Lower Paraná River. PMID:27442116

  5. First DNA Barcode Reference Library for the Identification of South American Freshwater Fish from the Lower Paraná River

    PubMed Central

    Brancolini, Florencia; del Pazo, Felipe; Posner, Victoria Maria; Grimberg, Alexis; Arranz, Silvia Eda

    2016-01-01

    Valid fish species identification is essential for biodiversity conservation and fisheries management. Here, we provide a sequence reference library based on mitochondrial cytochrome c oxidase subunit I for a valid identification of 79 freshwater fish species from the Lower Paraná River. Neighbour-joining analysis based on K2P genetic distances formed non-overlapping clusters for almost all species with a ≥99% bootstrap support each. Identification was successful for 97.8% of species as the minimum genetic distance to the nearest neighbour exceeded the maximum intraspecific distance in all these cases. A barcoding gap of 2.5% was apparent for the whole data set with the exception of four cases. Within-species distances ranged from 0.00% to 7.59%, while interspecific distances varied between 4.06% and 19.98%, without considering Odontesthes species with a minimum genetic distance of 0%. Sequence library validation was performed by applying BOLDs BIN analysis tool, Poisson Tree Processes model and Automatic Barcode Gap Discovery, along with a reliable taxonomic assignment by experts. Exhaustive revision of vouchers was performed when a conflicting assignment was detected after sequence analysis and BIN discordance evaluation. Thus, the sequence library presented here can be confidently used as a benchmark for identification of half of the fish species recorded for the Lower Paraná River. PMID:27442116

  6. Preserving the Historical Record of American Labor: Union-Library Archival Services Partnerships, Recent Trends, and Future Prospects.

    ERIC Educational Resources Information Center

    Connors, Thomas James

    2002-01-01

    Reviews efforts by academic research institutions to capture and preserve archival records of American labor institutions, focusing on a recent project to assess the state of labor archives efforts and the challenges facing union officials and labor archivists. Describes the Labor Archives Project (LAP), including the research methodology and…

  7. 5-ALA based photodynamic management of glioblastoma

    NASA Astrophysics Data System (ADS)

    Rühm, Adrian; Stepp, Herbert; Beyer, Wolfgang; Hennig, Georg; Pongratz, Thomas; Sroka, Ronald; Schnell, Oliver; Tonn, Jörg-Christian; Kreth, Friedrich-Wilhelm

    2014-03-01

    Objective: Improvement of the clinical outcome of glioblastoma (GBM) patients by employment of fluorescence and photosensitization on the basis of 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX). Methods: In this report the focus is laid on the use of tumor selective PpIX fluorescence for stereotactic biopsy sampling and intra-operative treatment monitoring. In addition, our current concept for treatment planning is presented. For stereotactic interstitial photodynamic therapy (iPDT), radial diffusers were implanted into the contrast enhancing tumor volume. Spectroscopic measurements of laser light transmission and fluorescence between adjacent fibers were performed prior, during and post PDT. Results: PpIX concentrations in primary glioblastoma tissue show high intra- and inter-patient variability, but are usually sufficient for an effective PDT. During individual treatment attempts with 5-ALA based GBM-iPDT, transmission and fluorescence measurements between radial diffusers gave the following results: 1. In some cases, transmission after PDT is considerably reduced compared to the value before PDT, which may be attributable to a depletion of oxygenated hemoglobin and/or diffuse bleeding. 2. PpIX fluorescence is efficiently photobleached during PDT in all cases. Conclusion: iPDT with assessment of PpIX fluorescence and photobleaching is a promising treatment option. Individualization of treatment parameters appears to bear a potential to further improve clinical outcomes.

  8. Gateways, Gatekeepres, and Roles in the Information Omniverse. Proceedings of the Symposium of the Association of Research Libraries and Association of American University Presses (3rd, Washington, D.C., November 13-15, 1993).

    ERIC Educational Resources Information Center

    Okerson, Ann, Ed.; Mogge, Dru, Ed.

    This volume contains the proceedings of the third joint symposium of the Association of Research Libraries (ARL) and the Association of American University Presses (AAUP). The following papers were presented: "Opening Remarks for the ARL-AAUP Symposium" (Lisa Freeman); the keynote address, "We're All in this Together, Aren't We?" (Bruce Sterling);…

  9. Who, What and How? Commentary on Cheney, F. N. (1963) the Teaching of Reference in American Library Schools. (Journal of Education for Librarianship, 3(3), 188-198)

    ERIC Educational Resources Information Center

    Smith, Linda C.

    2015-01-01

    Cheney's paper was the first major article on the subject of teaching reference in American library schools. In the article, she addressed three questions: (1) Who is teaching reference?; (2) What is being taught?; and (3) How is it being taught? In this article, Linda Smith discusses how the teaching of reference has changed in the more than 50…

  10. Losing Libraries, Saving Libraries

    ERIC Educational Resources Information Center

    Miller, Rebecca

    2010-01-01

    This summer, as public libraries continued to get budget hit after budget hit across the country, several readers asked for a comprehensive picture of the ravages of the recession on library service. In partnership with 2010 Movers & Shakers Laura Solomon and Mandy Knapp, Ohio librarians who bought the Losing Libraries domain name, "LJ" launched…

  11. Library Information-Processing System

    NASA Technical Reports Server (NTRS)

    1985-01-01

    System works with Library of Congress MARC II format. System composed of subsystems that provide wide range of library informationprocessing capabilities. Format is American National Standards Institute (ANSI) format for machine-readable bibliographic data. Adaptable to any medium-to-large library.

  12. OCLC and Rural Library Service.

    ERIC Educational Resources Information Center

    Walters, Clarence R.

    This discussion of ways in which OCLC can be used by rural libraries to enhance the library services offered to rural Americans suggests that OCLC is a type of technology that can be used to overcome the insufficiency of funds to finance library services. OCLC products and services that are particularly relevant to small, rural public libraries…

  13. 33 CFR 110.194 - Mobile Bay, Ala., at entrance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Mobile Bay, Ala., at entrance. 110.194 Section 110.194 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.194 Mobile Bay, Ala., at entrance. (a) The...

  14. 33 CFR 110.194 - Mobile Bay, Ala., at entrance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Mobile Bay, Ala., at entrance. 110.194 Section 110.194 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.194 Mobile Bay, Ala., at entrance. (a) The...

  15. Rural Libraries: A Forum for Rural Library Service. Volume X, 1990.

    ERIC Educational Resources Information Center

    Sheller, Rebekah, Ed.

    1990-01-01

    The two issues of the journal "Rural Libraries" for 1990 contain a total of seven articles. "Cooperation and Rural Libraries," by Jackie Schmitt, reports on a nationwide survey of 119 rural libraries' participation in intrastate library cooperatives. "Rural Public Library Service to Native Americans," by Susan Hollaran, outlines strategies for the…

  16. State Library Agencies and Member Libraries of the Association of Research Libraries. Final Report of Two Surveys.

    ERIC Educational Resources Information Center

    Chobot, Mary C.

    State Library Agencies (SLAs) and library members of the Association of Research Libraries (ARL) were surveyed to collect data from potential audiences for American Memory products to assist the planners for this Library of Congress (LC) project. This summary report briefly explains the purpose of the surveys; describes the survey methodology and…

  17. Synthesis and biological evaluation of a focused library of beauveriolides.

    PubMed

    Nagai, Kenichiro; Doi, Takayuki; Ohshiro, Taichi; Sunazuka, Toshiaki; Tomoda, Hiroshi; Takahashi, Takashi; Omura, Satoshi

    2008-08-01

    Fungal beauveriolide III (1b), discovered as an inhibitor of lipid droplet accumulation in mouse macrophages and showing antiatherogenic activity in mouse model, consists of l-Phe, l-Ala, d-allo-Ile, and (3S, 4S)-3-hydroxy-4-methyloctanoic acid moieties. A combinatorial library of beauveriolide analogues focusing on l-Ala and d-allo-Ile of 1b was synthesized by combinatorial synthesis. Among them, d-Ala analogues consisting of A{2} improved their solubility, while those with 7{1,3,2},7{2,3,1}, and 7{2,3,2} were 20 times more potent than 1b. PMID:18620856

  18. Nicaragua's Libraries: A Struggle for Survival.

    ERIC Educational Resources Information Center

    Chepesiuk, Ron

    1989-01-01

    Description of the effects of the revolution, U.S. government policy, and natural disasters on the economic climate in Nicaragua focuses on problems faced by the country's libraries and library school. Support and funding provided to Nicaraguan libraries by American library groups are reviewed, and attitudes of Nicaraguan librarians toward the…

  19. Confidentiality of Library Records: Renewed Concerns.

    ERIC Educational Resources Information Center

    Schmidt, C. James

    1988-01-01

    Discusses the Federal Bureau of Investigation's Library Awareness Program and presents the American Library Association's policy on confidentiality of library records and suggested procedures for implementing the policy. Relevant state and federal legislation are summarized, and suggestions are offered for library administrators dealing with the…

  20. Library Cooperation.

    ERIC Educational Resources Information Center

    Lund, Patricia; And Others

    1993-01-01

    Includes nine articles that discuss cooperative library networking in Illinois. Highlights include library systems as cooperative agencies; PALI (Private Academic Libraries of Illinois); rural school and public library development; systemwide users; regional medical libraries; virtual libraries and the Coalition for Networked Information; a…

  1. Structure of vancomycin and a vancomycin/D-Ala-D-Ala complex in solution

    SciTech Connect

    Molinari, H.; Pastore, A. ); Lian, Luyun ); Hawkes, G.E.; Sales, K. )

    1990-03-06

    Restrained molecular dynamics simulations were used to study the interactions between the glycopeptide antibiotic vancomycin and the dipeptide Ac-D-Ala-D-Ala. Restraints were obtained from a combination of homonuclear and heteronuclear two-dimensional NMR experiments (NOESY, ROESY, {sup 1}H-{sup 15}N inverse correlation). The comparison between the structures obtained for vancomycin alone and for the complex suggests a new hypothesis on the binding mode of this system. The numerical simulations were not straightforward because vancomycin is made of building blocks for which standard force-fields are not available. The representation of unusual chemical environments is also mandatory. The authors believe that the extension of the force-field parameters to their system could be of more general interest. Furthermore, they consider vancomycin and its complex a good example for exploring the more general problem of molecular recognition, a challenge that has been widely approached in the past few years but for which no unique and general methodology has, so far, been recognized.

  2. John Ash, ALA., Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, ALA., Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINTH FLOOR NORTH OFFICE WING SHOWING PARTITIONS, WINDOWS AND RADIATOR, FACING SOUTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  3. PARP1 Val762Ala polymorphism reduces enzymatic activity

    SciTech Connect

    Wang Xiaogan; Wang Zhaoqi; Tong Weimin . E-mail: tong@iarc.fr; Shen Yan

    2007-03-02

    Poly(ADP-ribose) polymerase 1 (PARP1) modifies a variety of nuclear proteins by poly(ADP-ribosyl)ation, and plays diverse roles in molecular and cellular processes. A common PARP1 single nucleotide polymorphism (SNP) at codon 762, resulting in the substitution of alanine (Ala) for valine (Val) in the catalytic domain has been implicated in susceptibility to cancer. To characterize the functional effect of this polymorphism on PARP1, we performed in vitro enzymatic analysis on PARP1-Ala762 and PARP1-Val762. We found that PARP1-Ala762 displayed 57.2% of the activity of PARP1-Val762 for auto-poly(ADP-ribosyl)ation and 61.9% of the activity of PARP1-Val762 for trans-poly(ADP-ribosyl)ation of histone H1. The kinetic characterization revealed that the K {sub m} of PARP1-Ala762 was increased to a 1.2-fold of the K {sub m} of PARP1-Val762 for trans-poly(ADP-ribosyl)ation. Thus, the PARP1 Val762Ala polymorphism reduces the enzymatic activity of PARP1 by increasing K {sub m}. This finding suggests that different levels of poly(ADP-ribosyl)ation by PARP1 might aid in understanding Cancer risk of carriers of the PARP1 Val762Ala polymorphism.

  4. Synthesis, DNA recognition and cleavage studies of novel tetrapeptide complexes, Cu(II)/Zn(II)-Ala-Pro-Ala-Pro

    NASA Astrophysics Data System (ADS)

    Arjmand, Farukh; Jamsheera, A.; Mohapatra, D. K.

    2013-05-01

    New tetrapeptide complexes Cu(II)·Ala-Pro-Ala-Pro (1) and Zn(II)·Ala-Pro-Ala-Pro (2) were synthesized from the reaction of tetrapeptide, Ala-Pro-Ala-Pro and CuCl2/ZnCl2 and were thoroughly characterized by elemental analysis, IR,1H and 13C NMR (in case of 2), ESI-MS, UV and molar conductance measurements. The solution stability study was carried out employing UV-vis absorption titrations over a broad range of pH which suggested the stability of the complexes in solution. In vitro interaction of complexes 1 and 2 with CT-DNA was studied employing UV-vis, fluorescence, circular dichroic and viscometry studies. To throw insight into molecular binding event at the target site, UV-vis titrations of 1 and 2 with mononucleotides of interest viz.; 5'-GMP and 5'-TMP were carried out. Cleavage activity of the complexes with pBR322 plasmid DNA was evaluated by agarose gel electrophoresis and, the electrophoresis pattern demonstrated that both the complexes 1 and 2 are efficient cleavage agents. Further, the Cu(II) complex displayed efficient oxidative cleavage of supercoiled DNA while various reactive oxygen species are responsible for the cleavage in Zn(II) complex.

  5. Book Storage in Academic Libraries. A Report Submitted to the Council on Library Resources.

    ERIC Educational Resources Information Center

    Piternick, George

    A study was made to determine the present state of book storage in large North American academic libraries. A letter was sent to every academic library in the Association of Research Libraries (ARL) to inquire if they engaged in book storage. From the 35 which answered affirmatively, 15 were selected for visitation: the libraries of the…

  6. Censorship of Library Books in School Library Media Centers Today.

    ERIC Educational Resources Information Center

    Saykanic, Donna

    For many years, there has been pressure on American schools to restrict or deny students access to books or periodicals deemed objectionable by some individual or group on moral, political, religious, ethnic, racial, or philosophical grounds. Censorship of library books in school media centers is present today. The library media specialist is…

  7. The Carboxyl Terminus of Eremomycin Facilitates Binding to the Non-d-Ala-d-Ala Segment of the Peptidoglycan Pentapeptide Stem.

    PubMed

    Chang, James; Zhou, Hongyu; Preobrazhenskaya, Maria; Tao, Peng; Kim, Sung Joon

    2016-06-21

    Glycopeptide antibiotics inhibit cell wall biosynthesis in Gram-positive bacteria by targeting the peptidoglycan (PG) pentapeptide stem structure (l-Ala-d-iso-Gln-l-Lys-d-Ala-d-Ala). Structures of the glycopeptide complexed with a PG stem mimic have shown that the d-Ala-d-Ala segment is the primary drug binding site; however, biochemical evidence suggests that the glycopeptide-PG interaction involves more than d-Ala-d-Ala binding. Interactions of the glycopeptide with the non-d-Ala-d-Ala segment of the PG stem were investigated using solid-state nuclear magnetic resonance (NMR). LCTA-1421, a double (15)N-enriched eremomycin derivative with a C-terminal [(15)N]amide and [(15)N]Asn amide, was complexed with whole cells of Staphylococcus aureus grown in a defined medium containing l-[3-(13)C]Ala and d-[1-(13)C]Ala in the presence of alanine racemase inhibitor alaphosphin. (13)C{(15)N} and (15)N{(13)C} rotational-echo double-resonance (REDOR) NMR measurements determined the (13)C-(15)N internuclear distances between the [(15)N]Asn amide of LCTA-1421 and the (13)C atoms of the bound d-[1-(13)C]Ala-d-[1-(13)C]Ala to be 5.1 and 4.8 Å, respectively. These measurements also determined the distance from the C-terminal [(15)N]amide of LCTA-1421 to the l-[3-(13)C]Ala of PG to be 3.5 Å. The measured REDOR distance constraints position the C-terminus of the glycopeptide in the proximity of the l-Ala of the PG, suggesting that the C-terminus of the glycopeptide interacts near the l-Ala segment of the PG stem. In vivo REDOR measurements provided structural insight into how C-terminally modified glycopeptide antibiotics operate. PMID:27243469

  8. Fluorescence-Guided Resection of Malignant Glioma with 5-ALA

    PubMed Central

    Kaneko, Sadahiro

    2016-01-01

    Malignant gliomas are extremely difficult to treat with no specific curative treatment. On the other hand, photodynamic medicine represents a promising technique for neurosurgeons in the treatment of malignant glioma. The resection rate of malignant glioma has increased from 40% to 80% owing to 5-aminolevulinic acid-photodynamic diagnosis (ALA-PDD). Furthermore, ALA is very useful because it has no serious complications. Based on previous research, it is apparent that protoporphyrin IX (PpIX) accumulates abundantly in malignant glioma tissues after ALA administration. Moreover, it is evident that the mechanism underlying PpIX accumulation in malignant glioma tissues involves an abnormality in porphyrin-heme metabolism, specifically decreased ferrochelatase enzyme activity. During resection surgery, the macroscopic fluorescence of PpIX to the naked eye is more sensitive than magnetic resonance imaging, and the alert real time spectrum of PpIX is the most sensitive method. In the future, chemotherapy with new anticancer agents, immunotherapy, and new methods of radiotherapy and gene therapy will be developed; however, ALA will play a key role in malignant glioma treatment before the development of these new treatments. In this paper, we provide an overview and present the results of our clinical research on ALA-PDD. PMID:27429612

  9. Fluorescence-Guided Resection of Malignant Glioma with 5-ALA.

    PubMed

    Kaneko, Sadahiro; Kaneko, Sadao

    2016-01-01

    Malignant gliomas are extremely difficult to treat with no specific curative treatment. On the other hand, photodynamic medicine represents a promising technique for neurosurgeons in the treatment of malignant glioma. The resection rate of malignant glioma has increased from 40% to 80% owing to 5-aminolevulinic acid-photodynamic diagnosis (ALA-PDD). Furthermore, ALA is very useful because it has no serious complications. Based on previous research, it is apparent that protoporphyrin IX (PpIX) accumulates abundantly in malignant glioma tissues after ALA administration. Moreover, it is evident that the mechanism underlying PpIX accumulation in malignant glioma tissues involves an abnormality in porphyrin-heme metabolism, specifically decreased ferrochelatase enzyme activity. During resection surgery, the macroscopic fluorescence of PpIX to the naked eye is more sensitive than magnetic resonance imaging, and the alert real time spectrum of PpIX is the most sensitive method. In the future, chemotherapy with new anticancer agents, immunotherapy, and new methods of radiotherapy and gene therapy will be developed; however, ALA will play a key role in malignant glioma treatment before the development of these new treatments. In this paper, we provide an overview and present the results of our clinical research on ALA-PDD. PMID:27429612

  10. Medical Libraries Around the World

    PubMed Central

    Brodman, Estelle

    1971-01-01

    A discussion is given of the buildings and equipment, staffs, and services of a number of medical libraries around the world, with special emphasis on American, European, and Asiatic medical libraries. Differences are explained on the basis of the traditions of the different countries, and the essential similarities pointed out. PMID:5582086

  11. Studying the Independent School Library

    ERIC Educational Resources Information Center

    Cahoy, Ellysa Stern; Williamson, Susan G.

    2008-01-01

    In 2005, the American Association of School Librarians' Independent Schools Section conducted a national survey of independent school libraries. This article analyzes the results of the survey, reporting specialized data and information regarding independent school library budgets, collections, services, facilities, and staffing. Additionally, the…

  12. Library Education in Revolutionary Nicaragua.

    ERIC Educational Resources Information Center

    Bloch, Thomas; Acevedo, Antonio

    1988-01-01

    Discussion of developments that have taken place in library education in Nicaragua since the establishment of the revolutionary government highlights funding sources, faculty composition, enrollment trends, and future prospects for seminar programs and the Central American University library program are discussed. (14 references) (CLB)

  13. Libraries and the Mobile Web

    ERIC Educational Resources Information Center

    Hanson, Cody

    2011-01-01

    In 2011, cell phones and mobile devices are ubiquitous. The vast majority of Americans now own cell phones, and over half of them have mobile access to the Internet through a phone or other mobile device. For libraries to stay relevant, they must be able to offer content and services through the mobile web. In this issue of "Library Technology…

  14. Finding Materials on American Popular Culture in the MSU Libraries: Popular Music, Television, Comics, Popular Fiction, Movies. How to Find Series No. 9.

    ERIC Educational Resources Information Center

    Scott, Randall W., Comp.

    An introduction to popular culture materials in the Michigan State University Libraries, this combination library guide and bibliography presents finding tools for popular fiction, comic materials, popular music, movies, and television programming. It provides instruction on the use of the card catalog, suggested subject heading search terms, and…

  15. Application of 5-ALA for differential diagnostics of stomach diseases

    NASA Astrophysics Data System (ADS)

    Okhotnikova, Natalja L.; Dadvany, Sergey A.; Kuszin, Michail I.; Kharnas, Sergey S.; Zavodnov, Victor Y.; Sklyanskaya, Olga A.; Loschenov, Victor B.; Volkova, Anna I.; Agafonov, Valery V.

    2001-01-01

    59 patients with stomach diseases including gastric cancer or polyp, gastritis, esofagus disease were investigated. Before gastroscopy all patients were given 5-ALA in doses 5mg, 10mg and 20mg per 1kg of body weight orally. Fluorescence diagnostics which estimates concentration of ALA-induced PPIX in regular and alternated tissues of gastric mucosa were carried out in 2-4 hours. Using of 5-ALA has shown high diagnostic effectiveness for differential diagnostics of stomach diseases. This technique has proved 10 diagnosis of cancer and revealed 15 malignant stomach diseases including 4 cancer in situ for patients with preliminary diagnosis of gastric ulcer. It also revealed 5 patients with enhanced fluorescence for which aimed biopsy has shown high degree of inflammation process. The latter were assigned as a risk group.

  16. Educational Resources in the ASCC Library

    ERIC Educational Resources Information Center

    Lin, Steven

    2006-01-01

    After two years of construction, American Samoa Community College opened its new library on September 2, 2003. The library is located on the east side of campus and is equipped with ten computer workstations, four online public access catalogs, three copying machines, and an elevator that is in compliance with the Americans with Disabilities Act.…

  17. Library 2000.

    ERIC Educational Resources Information Center

    Drake, Miriam A.

    In fall 1984, the Georgia Institute of Technology administration and library staff began planning for Library 2000, a project aimed at creating a showcase library to demonstrate the application of the latest information technology in an academic and research environment. The purposes of Library 2000 include: increasing awareness of students,…

  18. Current Issues and the Veterinary Medical Library

    ERIC Educational Resources Information Center

    Nault, Andre J.

    2010-01-01

    Veterinary medical libraries and librarians are unique. There are now 33 veterinary colleges in North America, and in accordance with American Veterinary Medical Association accreditation, each has a library managed by an accredited librarian. Colleges with veterinary programs often maintain specialized branch libraries to support the degree,…

  19. Contributions to the History of Library Terminology.

    ERIC Educational Resources Information Center

    Shapiro, Fred R.

    1989-01-01

    Discusses the historical method in lexicography, the general characteristics of library terminology, and the current state of library lexicography. Presents a glossary which lists quotations supplementing the coverage of library-related vocabulary in the "Oxford English Dictionary" (OED) and the "Dictionary of Americanisms" (DA). (LRW)

  20. Sex, Kids, and the Public Library.

    ERIC Educational Resources Information Center

    Mason, Marilyn Gell

    1997-01-01

    Considers issues relating to children's access to information on the Internet in public libraries. Topics include censorship versus selection; First Amendment rights; the American Library Association's challenge to the Communications Decency Act; filtering software; and the role of the public library. (LRW)

  1. IFLA General Conference, 1989. Division of Libraries Serving the General Public. Section on Children's Libraries; Section of School Libraries; Section of Libraries Serving Disadvantaged Persons. Booklet 30.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Fifteen papers from the Division of Libraries Serving the General Public are included in this collection: "When the Children's Library Meets the Museum" (French and English versions; Annie Pissard); "Value of Library Service for Children Literature in France" (Aline Eisenegger); "The Latin American Literature in France" (Aline Eisenegger); "The…

  2. Library Services in the Digital Age

    ERIC Educational Resources Information Center

    Zickuhr, Kathryn; Rainie, Lee; Purcell, Kristen

    2013-01-01

    This report explores the changing world of library services by exploring the activities at libraries that are already in transition and the kinds of services citizens would like to see if they could redesign libraries themselves. It is part of a larger research effort by the Pew Research Center's Internet & American Life Project that is exploring…

  3. The Value of Research in Academic Libraries

    ERIC Educational Resources Information Center

    Perkins, Gay Helen; Slowik, Amy J. W.

    2013-01-01

    In the summer of 2010, two researchers interviewed twenty-three library administrators of comparable academic libraries at American universities for their views of the value of research in academic libraries. The interview questions focused on the administrators' perceived value of academic librarians' research, incentives given to academic…

  4. Silk gland-specific tRNA(Ala) genes interact more weakly than constitutive tRNA(Ala) genes with silkworm TFIIIB and polymerase III fractions.

    PubMed Central

    Sullivan, H S; Young, L S; White, C N; Sprague, K U

    1994-01-01

    Constitutive and silk gland-specific tRNA(Ala) genes from silkworms have very different transcriptional properties in vitro. Typically, the constitutive type, which encodes tRNA(AlaC), directs transcription much more efficiently than does the silk gland-specific type, which encodes tRNA(AlaSG). We think that the inefficiency of the tRNA(AlaCG) gene underlies its capacity to be turned off in non-silk gland cells. An economical model is that the tRNA(AlaSG) promoter interacts poorly, relative to the tRNA(AlaC) promoter, with one or more components of the basal transcription machinery. As a consequence, the tRNA(AlaSG) gene directs the formation of fewer transcription complexes or of complexes with reduced cycling ability. Here we show that the difference in the number of active transcription complexes accounts for the difference in tRNA(AlaC) and tRNA(AlaSG) transcription rates. To determine whether a particular component of the silkworm transcription machinery is responsible for reduced complex formation on the tRNA(AlaSG) gene, we measured competition by templates for defined fractions of this machinery. We find that the tRNA(AlaSG) gene is greatly impaired, in comparison with the tRNA(AlaC) gene, in competition for either TFIIIB or RNA polymerase III. Competition for each of these fractions is also strongly influenced by the nature of the 5' flanking sequence, the promoter element responsible for the distinctive transcriptional properties of tRNA(AlaSG) and tRNA(AlaC) genes. These results suggest that differential interaction with TFIIIB or RNA polymerase III is a critical functional distinction between these genes. Images PMID:8114713

  5. ALA-induced PpIX fluorescence in epileptogenic tissue

    NASA Astrophysics Data System (ADS)

    Kleen, Jonathan K.; Valdes, Pablo A.; Harris, Brent T.; Holmes, Gregory L.; Paulsen, Keith D.; Roberts, David W.

    2011-03-01

    Astrogliotic tissue displays markedly increased levels of ALA-induced PpIX fluorescence, making it useful for fluorescence-guided resection in glioma surgery. In patients with temporal lobe epilepsy (TLE) and corresponding animal models, there are areas of astrogliosis that often co-localize with the epileptic focus, which can be resected to eliminate seizures in the majority of treated patients. If this epileptogenic tissue can exhibit PpIX fluorescence that is sufficiently localized, it could potentially help identify margins in epilepsy surgery. We tested the hypothesis that ALA-induced PpIX fluorescence could visually accentuate epileptogenic tissue, using an established animal model of chronic TLE. An acute dose of pilocarpine was used to induce chronic seizure activity in a rat. This rat and a normal control were given ALA, euthanized, and brains examined post-mortem for PpIX fluorescence and neuropathology. Preliminary evidence indicates increased PpIX fluorescence in areas associated with chronic epileptic changes and seizure generation in TLE, including the hippocampus and parahippocampal areas. In addition, strong PpIX fluorescence was clearly observed in layer II of the piriform cortex, a region known for epileptic reorganization and involvement in the generation of seizures in animal studies. We are further investigating whether ALA-induced PpIX fluorescence can consistently identify epileptogenic zones, which could warrant the extension of this technique to clinical studies for use as an adjuvant guidance technology in the resection of epileptic tissue.

  6. ALAM and ALAS: Questioning Error Assignments in Unidimensional Guttman Scaling

    ERIC Educational Resources Information Center

    Wimberley, Ronald C.

    1976-01-01

    When researchers use the Guttman scalogram rather than multidimensional techniques, scalogram error assignment techniques should be questioned. An alternative to the customary minimizing error rule is suggested through ALAM and ALAS criteria which use ordinal information in scalable item marginals. (Author)

  7. Discover Earth: An earth system science program for libraries and their communities

    NASA Astrophysics Data System (ADS)

    Curtis, L.; Dusenbery, P.

    2010-12-01

    The view from space has deepened our understanding of Earth as a global, dynamic system. Instruments on satellites and spacecraft, coupled with advances in ground-based research, have provided us with astonishing new perspectives of our planet. Now more than ever, enhancing the public’s understanding of Earth’s physical and biological systems is vital to helping citizens make informed policy decisions especially when they are faced with the consequences of global climate change. In spite of this relevance, there are many obstacles to achieving broad public understanding of key earth system science (ESS) concepts. Strategies for addressing climate change can only succeed with the full engagement of the general public. As reported by U.S. News and World Report in 2010, small towns in rural America are emerging as the front line in the climate change debate in the country. The Space Science Institute’s National Center for Interactive Learning (NCIL) in partnership with the American Library Association (ALA), the Lunar and Planetary Institute (LPI), and the National Girls Collaborative Project (NGCP) have received funding from NSF to develop a national project called the STAR Library Education Network: a hands-on learning program for libraries and their communities (or STAR-Net for short). STAR stands for Science-Technology, Activities and Resources. There are two distinct components of STAR-Net: Discover Earth and Discover Tech. While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. The overarching goal of the project is to reach underserved youth and their families with informal STEM learning experiences. The Discover Earth part of STAR_Net will produce ESS

  8. Russian-American Seminar on Critical Thinking and the Library. Papers from the Seminar (Moscow, Russia, June 1-5, 1992). Occasional Papers Nos. 200-201.

    ERIC Educational Resources Information Center

    Oberman, Cerise, Ed.; Kimmage, Dennis, Ed.

    The purpose behind the Russian-American Seminar on Critical Thinking was to bring together librarians from both countries to provide an East-West perspective on the issue of critical thinking. This document presents 16 papers from the seminar as well as introductory remarks from a Russian and an American participant. Papers are as follows: "The…

  9. An African-American Bibliography: Science, Medicine, and Allied Fields. Selected Resources from the Collections of the New York State Library.

    ERIC Educational Resources Information Center

    Strasser, Theresa C., Comp.

    The second in a series of African-American bibliographies, this bibliography was issued in honor of both Black History Month and Inventors Day in February 1991. It focuses on the contributions of black Americans in the areas of science, technology, medicine, and allied fields such as dentistry and nursing. The materials cited emphasize the…

  10. Setting Up an Exchange Operation in the Small Special Library.

    ERIC Educational Resources Information Center

    Carter, Harriet H.

    1978-01-01

    Describes the planning process and the procedures established to get the Fels Research Institute Library started in exchange activities through the ALA Duplicates Exchange Union and the MLA Exchange. Methods for evaluating the success of these programs after one year are explained. (Author/MBR)

  11. Loss of the Arabidopsis thaliana P4-ATPases ALA6 and ALA7 impairs pollen fitness and alters the pollen tube plasma membrane.

    PubMed

    McDowell, Stephen C; López-Marqués, Rosa L; Cohen, Taylor; Brown, Elizabeth; Rosenberg, Alexa; Palmgren, Michael G; Harper, Jeffrey F

    2015-01-01

    Members of the P4 subfamily of P-type ATPases are thought to create and maintain lipid asymmetry in biological membranes by flipping specific lipids between membrane leaflets. In Arabidopsis, 7 of the 12 Aminophospholipid ATPase (ALA) family members are expressed in pollen. Here we show that double knockout of ALA6 and ALA7 (ala6/7) results in siliques with a ~2-fold reduction in seed set with a high frequency of empty seed positions near the bottom. Seed set was reduced to near zero when plants were grown under a hot/cold temperature stress. Reciprocal crosses indicate that the ala6/7 reproductive deficiencies are due to a defect related to pollen transmission. In-vitro growth assays provide evidence that ala6/7 pollen tubes are short and slow, with ~2-fold reductions in both maximal growth rate and overall length relative to wild-type. Outcrosses show that when ala6/7 pollen are in competition with wild-type pollen, they have a near 0% success rate in fertilizing ovules near the bottom of the pistil, consistent with ala6/7 pollen having short and slow growth defects. The ala6/7 phenotypes were rescued by the expression of either an ALA6-YFP or GFP-ALA6 fusion protein, which showed localization to both the plasma membrane and highly-mobile endomembrane structures. A mass spectrometry analysis of mature pollen grains revealed significant differences between ala6/7 and wild-type, both in the relative abundance of lipid classes and in the average number of double bonds present in acyl side chains. A change in the properties of the ala6/7 plasma membrane was also indicated by a ~10-fold reduction of labeling by lipophilic FM-dyes relative to wild-type. Together, these results indicate that ALA6 and ALA7 provide redundant activities that function to directly or indirectly change the distribution and abundance of lipids in pollen, and support a model in which ALA6 and ALA7 are critical for pollen fitness under normal and temperature-stress conditions. PMID:25954280

  12. Loss of the Arabidopsis thaliana P4-ATPases ALA6 and ALA7 impairs pollen fitness and alters the pollen tube plasma membrane

    PubMed Central

    McDowell, Stephen C.; López-Marqués, Rosa L.; Cohen, Taylor; Brown, Elizabeth; Rosenberg, Alexa; Palmgren, Michael G.; Harper, Jeffrey F.

    2015-01-01

    Members of the P4 subfamily of P-type ATPases are thought to create and maintain lipid asymmetry in biological membranes by flipping specific lipids between membrane leaflets. In Arabidopsis, 7 of the 12 Aminophospholipid ATPase (ALA) family members are expressed in pollen. Here we show that double knockout of ALA6 and ALA7 (ala6/7) results in siliques with a ~2-fold reduction in seed set with a high frequency of empty seed positions near the bottom. Seed set was reduced to near zero when plants were grown under a hot/cold temperature stress. Reciprocal crosses indicate that the ala6/7 reproductive deficiencies are due to a defect related to pollen transmission. In-vitro growth assays provide evidence that ala6/7 pollen tubes are short and slow, with ~2-fold reductions in both maximal growth rate and overall length relative to wild-type. Outcrosses show that when ala6/7 pollen are in competition with wild-type pollen, they have a near 0% success rate in fertilizing ovules near the bottom of the pistil, consistent with ala6/7 pollen having short and slow growth defects. The ala6/7 phenotypes were rescued by the expression of either an ALA6-YFP or GFP-ALA6 fusion protein, which showed localization to both the plasma membrane and highly-mobile endomembrane structures. A mass spectrometry analysis of mature pollen grains revealed significant differences between ala6/7 and wild-type, both in the relative abundance of lipid classes and in the average number of double bonds present in acyl side chains. A change in the properties of the ala6/7 plasma membrane was also indicated by a ~10-fold reduction of labeling by lipophilic FM-dyes relative to wild-type. Together, these results indicate that ALA6 and ALA7 provide redundant activities that function to directly or indirectly change the distribution and abundance of lipids in pollen, and support a model in which ALA6 and ALA7 are critical for pollen fitness under normal and temperature-stress conditions. PMID:25954280

  13. Special Libraries

    ERIC Educational Resources Information Center

    Lavendel, Giuliana

    1977-01-01

    Discusses problems involved in maintaining special scientific or engineering libraries, including budget problems, remote storage locations, rental computer retrieval systems, protecting trade secrets, and establishing a magnetic tape library. (MLH)

  14. Hydroxylation and Epoxidation of Fatty Acids by Bacillus megaterium ALA2

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bacillus megaterium ALA2 produces many new oxygenated fatty acids from linoleic acid. Strain ALA2 hydroxylated palmitic acid to omega-1, omega-2, and omega-3 hydroxy palmitate. Now we found that strain ALA2 also epoxidized linoleic acid to 12,13-epoxy-9(Z)-octadecenoic acid and 9,10-epoxy-12(Z)-oc...

  15. 75 FR 12254 - Official Trail Marker for the Ala Kahakai National Historic Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... National Park Service Official Trail Marker for the Ala Kahakai National Historic Trail AGENCY: National.... SUMMARY: This notice issues the official trail marker insignia of the Ala Kahakai National Historic Trail... P. Arakaki, Superintendent, Ala Kahakai National Historic Trail. The insignia depicted below...

  16. Guide to Sources: American History.

    ERIC Educational Resources Information Center

    Patterson, Thomas H., Comp.

    Designed to introduce students to some of the basic bibliographic tools in American history available in the Fogler Library at the University of Maine, this guide begins by listing examples of relevant Library of Congress Subject Headings and providing brief explanations of the call numbers and classification systems (Library of Congress and Dewey…

  17. 1. Historic American Buildings Survey, drawn by Pierre du Simitiere ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, drawn by Pierre du Simitiere (papers in Philadelphia Library) DRAWING OF REDWOOD LIBRARY IN 1768. - Redwood Library, 50 Bellevue Avenue, Newport, Newport County, RI

  18. Library Skills.

    ERIC Educational Resources Information Center

    Paul, Karin; Kuhlthau, Carol C.; Branch, Jennifer L.; Solowan, Diane Galloway; Case, Roland; Abilock, Debbie; Eisenberg, Michael B.; Koechlin, Carol; Zwaan, Sandi; Hughes, Sandra; Low, Ann; Litch, Margaret; Lowry, Cindy; Irvine, Linda; Stimson, Margaret; Schlarb, Irene; Wilson, Janet; Warriner, Emily; Parsons, Les; Luongo-Orlando, Katherine; Hamilton, Donald

    2003-01-01

    Includes 19 articles that address issues related to library skills and Canadian school libraries. Topics include information literacy; inquiry learning; critical thinking and electronic research; collaborative inquiry; information skills and the Big 6 approach to problem solving; student use of online databases; library skills; Internet accuracy;…

  19. Basic principles of fluorescence detection with use of 5-ALA

    NASA Astrophysics Data System (ADS)

    Baumgartner, Reinhold; Stepp, Herbert G.

    2000-06-01

    5-Aminolevulinic acid (5-ALA) has been proven to induce selective accumulation of flourescent Protoporphyrin IX (PPIX) in many types of malignant tissue. According to the target to treatment different routes of topical and systemical application of 5-ALA can be chosen. They include techniques like inhalation, installation and rinsing. For fluorescence detection a lamp based system have been developed in the laser-Forschungslabor in Munich together with Storz company. By skillful balancing of excitation filter centered around 400 nm and the observation filter with transmission above 450 nm images with high color contrast can be obtained. The universal application of the D-LIGHT could be demonstrated in different clinical disciplines like urology, neurosurgery, ENT clinic, gynecology and others.

  20. Umberto Eco on Libraries: A Discussion of "De Biblioteca."

    ERIC Educational Resources Information Center

    Winter, Michael F.

    1994-01-01

    Discusses a scholar's reactions to libraries made by Umberto Eco in "De Biblioteca." Topics addressed include functions of libraries, including collecting; accessibility of materials; the scholar's creative use of libraries, and discovering materials not looked for or known about; North American research libraries; photocopying; and better…

  1. Using the "Documenting the American South" Digital Library in the Social Studies: A Case Study of the Experiences of Teachers in the Field

    ERIC Educational Resources Information Center

    McGlinn, Meghan

    2007-01-01

    Two current themes in social studies education- the inclusion of technology and the emphasis on "doing history"--intersect with the use of Web-based or digital primary sources in the classroom. Digital libraries make these resources available to students and teachers interested in accessing rare primary documents in order to study the…

  2. Accessibility Trends among Academic Library and Library School Web Sites in the USA and Canada

    ERIC Educational Resources Information Center

    Schmetzke, Axel; Comeaux, David

    2009-01-01

    This paper focuses on the accessibility of North American library and library school Web sites for all users, including those with disabilities. Web accessibility data collected in 2006 are compared to those of 2000 and 2002. The findings of this follow-up study continue to give cause for concern: Despite improvements since 2002, library and…

  3. Walking the Road between Libraries: Best Practices in School and Public Library Cooperative Activities

    ERIC Educational Resources Information Center

    Bush, Gail

    2006-01-01

    The American Association of School Librarians (AASL)/Association for Library Service to Children (ALSC)/Young Adult Library Service Association (YALSA) Joint Task Force on School/Public Library Cooperative Activities has been collecting and disseminating information about cooperative activities around the country since the first meeting in January…

  4. Public Library Planning: Case Studies for Management. The Greenwood Library Management Collection.

    ERIC Educational Resources Information Center

    Sutton, Brett

    This book is the result of a set of case studies that were performed in four American public libraries between 1989 and 1992. The goal of the research was to describe the effect that planning has had in a representative set of libraries, focusing planning as a social phenomenon. The city, county, federated, and suburban library are examined.…

  5. The complex filling of alae crater, Kilauea Volcano, Hawaii

    USGS Publications Warehouse

    Swanson, D.A.; Duffield, W.A.; Jackson, D.B.; Peterson, D.W.

    1972-01-01

    Since February 1969 Alae Crater, a 165-m-deep pit crater on the east rift of Kilauea Volcano, has been completely filled with about 18 million m3 of lava. The filling was episodic and complex. It involved 13 major periods of addition of lava to the crater, including spectacular lava falls as high as 100 m, and three major periods of draining of lava from the crater. Alae was nearly filled by August 3, 1969, largely drained during a violent ground-cracking event on August 4, 1969, and then filled to the low point on its rim on October 10, 1969. From August 1970 to May 1971, the crater acted as a reservoir for lava that entered through subsurface tubes leading from the vent fissure 150 m away. Another tube system drained the crater and carried lava as far as the sea, 11 km to the south. Much of the lava entered Alae by invading the lava lake beneath its crust and buoying the crust upward. This process, together with the overall complexity of the filling, results in a highly complicated lava lake that would doubtless be misinterpreted if found in the fossil record. ?? 1972 Stabilimento Tipografico Francesco Giannini & Figli.

  6. Characterization of the l-alanine exporter AlaE of Escherichia coli and its potential role in protecting cells from a toxic-level accumulation of l-alanine and its derivatives

    PubMed Central

    Kim, Seryoung; Ihara, Kohei; Katsube, Satoshi; Hori, Hatsuhiro; Ando, Tasuke; Isogai, Emiko; Yoneyama, Hiroshi

    2015-01-01

    We previously reported that the alaE gene of Escherichia coli encodes the l-alanine exporter AlaE. The objective of this study was to elucidate the mechanism of the AlaE exporter. The minimum inhibitory concentration of l-alanine and l-alanyl-l-alanine in alaE-deficient l-alanine-nonmetabolizing cells MLA301ΔalaE was 4- and >4000-fold lower, respectively, than in the alaE-positive parent cells MLA301, suggesting that AlaE functions as an efflux pump to avoid a toxic-level accumulation of intracellular l-alanine and its derivatives. Furthermore, the growth of the alaE-deficient mutant derived from the l-alanine-metabolizing strain was strongly inhibited in the presence of a physiological level of l-alanyl-l-alanine. Intact MLA301ΔalaE and MLA301ΔalaE/pAlaE cells producing plasmid-borne AlaE, accumulated approximately 200% and 50%, respectively, of the [3H]l-alanine detected in MLA301 cells, suggesting that AlaE exports l-alanine. When 200 mmol/L l-alanine-loaded inverted membrane vesicles prepared from MLA301ΔalaE/pAlaE were placed in a solution containing 200 mmol/L or 0.34 μmol/L l-alanine, energy-dependent [3H]l-alanine accumulation occurred under either condition. This energy-dependent uphill accumulation of [3H]l-alanine was strongly inhibited in the presence of carbonyl cyanide m-chlorophenylhydrazone but not by dicyclohexylcarbodiimide, suggesting that the AlaE-mediated l-alanine extrusion was driven by proton motive force. Based on these results, physiological roles of the l-alanine exporter are discussed. PMID:26073055

  7. Characterization of the l-alanine exporter AlaE of Escherichia coli and its potential role in protecting cells from a toxic-level accumulation of l-alanine and its derivatives.

    PubMed

    Kim, Seryoung; Ihara, Kohei; Katsube, Satoshi; Hori, Hatsuhiro; Ando, Tasuke; Isogai, Emiko; Yoneyama, Hiroshi

    2015-08-01

    We previously reported that the alaE gene of Escherichia coli encodes the l-alanine exporter AlaE. The objective of this study was to elucidate the mechanism of the AlaE exporter. The minimum inhibitory concentration of l-alanine and l-alanyl-l-alanine in alaE-deficient l-alanine-nonmetabolizing cells MLA301ΔalaE was 4- and >4000-fold lower, respectively, than in the alaE-positive parent cells MLA301, suggesting that AlaE functions as an efflux pump to avoid a toxic-level accumulation of intracellular l-alanine and its derivatives. Furthermore, the growth of the alaE-deficient mutant derived from the l-alanine-metabolizing strain was strongly inhibited in the presence of a physiological level of l-alanyl-l-alanine. Intact MLA301ΔalaE and MLA301ΔalaE/pAlaE cells producing plasmid-borne AlaE, accumulated approximately 200% and 50%, respectively, of the [(3) H]l-alanine detected in MLA301 cells, suggesting that AlaE exports l-alanine. When 200 mmol/L l-alanine-loaded inverted membrane vesicles prepared from MLA301ΔalaE/pAlaE were placed in a solution containing 200 mmol/L or 0.34 μmol/L l-alanine, energy-dependent [(3) H]l-alanine accumulation occurred under either condition. This energy-dependent uphill accumulation of [(3) H]l-alanine was strongly inhibited in the presence of carbonyl cyanide m-chlorophenylhydrazone but not by dicyclohexylcarbodiimide, suggesting that the AlaE-mediated l-alanine extrusion was driven by proton motive force. Based on these results, physiological roles of the l-alanine exporter are discussed. PMID:26073055

  8. Native American Cultural Groups.

    ERIC Educational Resources Information Center

    Roy, Loriene, Comp.

    Part of a larger report on the Four Directions Project, an American Indian technology innovation project, this section includes 13 "pathfinders" to locating information on Native American and other indigenous cultural groups. The pathfinders were designed by students in the Graduate School of Library and Information Science at the University of…

  9. Technology Competency Requirements of ALA-Accredited Library Science Programs: An Updated Analysis

    ERIC Educational Resources Information Center

    Scripps-Hoekstra, Lindy; Carroll, Megan; Fotis, Theresa

    2014-01-01

    This study set out to provide an understanding of how LIS programs ensure that students are prepared for the demands of graduate study in the twenty-first century, how these expectations may have evolved since Kules's and McDaniel's previous 2008 study, and how various types of programs compare in their approaches. Content analysis was used to…

  10. African-American Heritage Collections Go Digital: Once Hidden Cultural Treasures Find the Route to Accessibility and Popularity through High Technology in Academic Libraries.

    ERIC Educational Resources Information Center

    Kenerson, Murle E.

    A wealth of African-American resources have remained "hidden resources," even as interest in and need for these rare documents has risen. Digitizing collections would make these materials available through the Internet and World Wide Web. Many of these materials reside in historically black institutions which oftentimes lack the resources to…

  11. African American Women. A Biographical Dictionary. Garland Reference Library of the Social Sciences, Volume 706. Biographical Dictionaries of Minority Women, Volume 2.

    ERIC Educational Resources Information Center

    Salem, Dorothy C., Ed.

    The nearly 300 biographical sketches in this dictionary focus on women who have made meaningful, although often unheralded, contributions to American history and culture. Although the collection concentrates on historical achievements, several women reflect contemporary accomplishments or historical firsts. The biographies span the time from…

  12. Non-Conserved Residues in Clostridium acetobutylicum tRNAAla Contribute to tRNA Tuning for Efficient Antitermination of the alaS T Box Riboswitch

    PubMed Central

    Liu, Liang-Chun; Grundy, Frank J.; Henkin, Tina M.

    2015-01-01

    The T box riboswitch regulates expression of amino acid-related genes in Gram-positive bacteria by monitoring the aminoacylation status of a specific tRNA, the binding of which affects the folding of the riboswitch into mutually exclusive terminator or antiterminator structures. Two main pairing interactions between the tRNA and the leader RNA have been demonstrated to be necessary, but not sufficient, for efficient antitermination. In this study, we used the Clostridium acetobutylicum alaS gene, which encodes alanyl-tRNA synthetase, to investigate the specificity of the tRNA response. We show that the homologous C. acetobutylicum tRNAAla directs antitermination of the C. acetobutylicum alaS gene in vitro, but the heterologous Bacillus subtilis tRNAAla (with the same anticodon and acceptor end) does not. Base substitutions at positions that vary between these two tRNAs revealed synergistic and antagonistic effects. Variation occurs primarily at positions that are not conserved in tRNAAla species, which indicates that these non-conserved residues contribute to optimal antitermination of the homologous alaS gene. This study suggests that elements in tRNAAla may have coevolved with the homologous alaS T box leader RNA for efficient antitermination. PMID:26426057

  13. Libraries program

    USGS Publications Warehouse

    2011-01-01

    The U.S. Congress authorized a library for the U.S. Geological Survey (USGS) in 1879. The library was formally established in 1882 with the naming of the first librarian and began with a staff of three and a collection of 1,400 books. Today, the USGS Libraries Program is one of the world's largest Earth and natural science repositories and a resource of national significance used by researchers and the public worldwide.

  14. Discover Earth: an earth system science program for libraries and their communities

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.

    2011-12-01

    The view from space has deepened our understanding of Earth as a global, dynamic system. Instruments on satellites and spacecraft, coupled with advances in ground-based research, have provided us with astonishing new perspectives of our planet. Now more than ever, enhancing the public's understanding of Earth's physical and biological systems is vital to helping citizens make informed policy decisions especially when they are faced with the consequences of global climate change. While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. The Space Science Institute's National Center for Interactive Learning (NCIL) in partnership with the American Library Association (ALA), the Lunar and Planetary Institute (LPI), and the National Girls Collaborative Project (NGCP) have received funding from NSF to develop a national project called the STAR Library Education Network: a hands-on learning program for libraries and their communities (or STAR-Net for short). STAR stands for Science-Technology, Activities and Resources. STAR-Net includes two exhibitions: Discover Earth and Discover Tech. The Discover Earth exhibition will focus on local earth science topics-such as weather, water cycle, and ecosystem changes-as well as a global view of our changing planet. The main take-away message (or Big Idea) for this exhibition is that the global environment changes - and is changed by - the host community's local environment. The project team is testing whether this approach will be a good strategy for engaging the public, especially in rural America. This presentation will provide an overview of the Discover Earth project and how it is integrating climate change ideas into the exhibit

  15. Photosensitization and mechanism of cytotoxicity induced by the use of ALA derivatives in photodynamic therapy

    PubMed Central

    Casas, A; Fukuda, H; Di Venosa, G; Batlle, A

    2001-01-01

    The use of more lipophilic derivatives of 5-aminolevulinic acid (ALA) is expected to have better diffusing properties, and after conversion into the parent ALA, to reach a higher protoporphyrin IX (PPIX) formation rate, thus improving the efficacy of topical photodynamic therapy (PDT). Here we have analysed the behaviour of 3 ALA derivatives (ALA methyl-ester, hexyl ester and a 2-sided derivative) regarding PPIX formation, efficiency in photosensitizing cells and mechanism of cellular death. The maximum amount of porphyrins synthesized from 0.6 mM ALA was 47 ± 8 ng/105 cells. The same amount was formed by a concentration 60-fold lower of hexyl-ALA and 2-fold higher of methyl-ALA. The 2-sided derivative failed to produce PPIX accumulation. Applying a 0.6 J cm−2 light dose, cell viability decreased to 50%. With the 1.5 J cm−2 light dose, less than 20% of the cells survive, and higher light doses produced nearly total cell killing. Comparing the PPIX production and the induced phototoxicity, the more the amount of porphyrins, the greater the cellular killing, and PPIX formed from either ALA or ALA-esters equally sensitize the cells to photoinactivation. ALA-PDT treated cells exhibited features of apoptosis, independently on the pro-photosensitizer employed. ALA-PDT can be improved with the use of ALA derivatives, reducing the amount of ALA necessary to induce efficient photosensitization. ©2001 Cancer Research Campaign http://www.bjcancer.com PMID:11461090

  16. Evidence for a Contribution of ALA Synthesis to Plastid-To-Nucleus Signaling

    SciTech Connect

    Czarnecki, Olaf; Gläßer, Christine; Chen, Jin-Gui; Mayer, Klaus F. X.; Grimm, Bernhard

    2012-01-01

    The formation of 5-aminolevulinic acid (ALA) in tetrapyrrole biosynthesis is widely controlled by environmental and metabolic feedback cues that determine the influx into the entire metabolic path. Because of its central role as the rate-limiting step, we hypothesized a potential role of ALA biosynthesis in tetrapyrrole-mediated retrograde signaling and exploited the direct impact of ALA biosynthesis on nuclear gene expression (NGE) by using two different approaches. Firstly, the Arabidopsis gun1, hy1 (gun2), hy2 (gun3), gun4 mutants showing uncoupled NGE from the physiological state of chloroplasts were thoroughly examined for regulatory modifications of ALA synthesis and transcriptional control in the nucleus. We found that reduced ALA-synthesizing capacity is common to analyzed gun mutants. Inhibition of ALA synthesis by gabaculine (GAB) that inactivates glutamate-1-semialdehyde aminotransferase and ALA feeding of wild-type and mutant seedlings corroborate the expression data of gun mutants. Transcript level of photosynthetic marker genes were enhanced in norflurazon (NF)-treated seedlings upon additional GAB treatment, while enhanced ALA amounts diminish these RNA levels in NF-treated wild-type in comparison to the solely NF-treated seedlings. Secondly, the impact of posttranslationally down-regulated ALA synthesis on NGE was investigated by global transcriptome analysis of GAB-treated Arabidopsis seedlings and the gun4-1 mutant, which is also characterized by reduced ALA formation. A common set of significantly modulated genes was identified indicating ALA synthesis as a potential signal emitter. The over-represented gene ontology categories of genes with decreased or increased transcript abundance highlight a few biological processes and cellular functions, which are remarkably affected in response to plastid-localized ALA biosynthesis. These results support the hypothesis that ALA biosynthesis correlates with retrograde signaling-mediated control of NGE.

  17. Summary recommendations for responsible monitoring and regulation of clinical software systems. American Medical Informatics Association, The Computer-based Patient Record Institute, The Medical Library Association, The Association of Academic Health Science Libraries, The American Health Information Management Association, and The American Nurses Association.

    PubMed

    Miller, R A; Gardner, R M

    1997-11-01

    Clinical software systems are becoming ubiquitous. A growing literature documents how these systems can improve health care delivery, but concerns about patient safety must now be formally addressed. In 1996, the U.S. Food and Drug Administration (FDA) called for discussions on regulation of software programs as medical devices. In response, a consortium of organizations dedicated to improving health care through information technology developed recommendations for the responsible regulation and monitoring of clinical software systems by users, vendors, and regulatory agencies. These recommendations were revised and approved by the American Medical informatics Association Public Policy Committee and Board. Other organizations reviewed, modified, and approved the recommendations, and the Boards of Directors of most of the organizations in the consortium endorsed the guidelines. The consortium proposes four categories of clinical system risk and four classes of monitoring and regulatory action that can be applied on the basis of the risk level. The consortium recommends that most clinical software systems be supervised locally and that developers of health care information systems adopt a code of good business practices. Budgetary and other constraints limit the type and number of systems that the FDA can regulate effectively; therefore, the FDA should exempt most clinical software systems and focus on systems that pose high clinical risk and provide limited opportunity for competent human intervention. PMID:9382409

  18. America's Star Libraries: Top-Rated Libraries

    ERIC Educational Resources Information Center

    Lance, Keith Curry; Lyons, Ray

    2009-01-01

    "Library Journal"'s national rating of public libraries, the "LJ" Index of Public Library Service 2009, Round 2, identifies 258 "star" libraries. Created by Keith Curry Lance and Ray Lyons and based on 2007 data from the IMLS, it rates 7,268 public libraries. The top libraries in each group get five, four, or three stars. All included libraries,…

  19. Libraries in California: MedlinePlus

    MedlinePlus

    ... Angeles, CA 90034 323-857-3925 National Asian Pacific American Families Against Substance Abuse 340 E. Second ... 7956 http://med.navy.mil.libguides.com/home Pacific College of Oriental Medicine Library/Learning Resources Center ...

  20. Library Advocacy

    ERIC Educational Resources Information Center

    Plunkett, Kate

    2010-01-01

    This paper is about the issue of advocacy. Standing at the vanguard of literacy, library media specialists have a unique role. However, it is time for media specialists to advocate their services in a proactive way. If library media specialists cannot, both individually and collectively, put advocacy at the forefront, then students will suffer the…

  1. Macintoshed Libraries.

    ERIC Educational Resources Information Center

    Valauskas, Edward J., Ed.; John, Nancy R., Ed.

    Contributed by librarians from public, academic, school, and special libraries, the 17 essays in this collection describe ways in which the Apple Macintosh is used in their libraries: (1) "Workstations and the Apple Macintosh" (Edward J. Valauskas); (2) "The Macintosh Experience at Chesapeake College" (Liz Cooper); (3) "ANSEL Character Set for the…

  2. Library Lighting.

    ERIC Educational Resources Information Center

    Metcalf, Keyes D.

    Chapter I provides a background and explains pertinent library lighting problems such as quality, function, aesthetics, intensity, and costs. Emphasis is on the quality and function of lighting for library users. Chapter II deals with the comments and answers to questions by persons who have a special interest and competence in the field of…

  3. Library Research.

    ERIC Educational Resources Information Center

    Wright, Nancy Kirkpatrick

    This workbook, designed for a Library Research course at Yavapai College, provides 15 lessons in advanced library reference skills. Each lesson provides explanatory text and reinforcement exercises. After Lesson I introduces specialized dictionaries and encyclopedias (e.g., for foreign languages, medicine, music, economics, social sciences, and…

  4. Differently Able: A Review of Academic Library Websites for People with Disabilities

    ERIC Educational Resources Information Center

    Cassner, Mary; Maxey-Harris, Charlene; Anaya, Toni

    2011-01-01

    This research is based on the Library Services for People with Disabilities Policy, which was approved by the American Library Association in 2001. The policy identified focus areas for libraries including library services, facilities, collections, and assistive technology. Library websites frequently convey this information to users. Our study…

  5. What If You Ran Your Bookstore Like a Library? The Troubled Book Business Can Learn from Libraries' Willingness to Share

    ERIC Educational Resources Information Center

    Fister, Barbara

    2008-01-01

    Ten years ago, stories like "B&N: The New College Library" (LJ 2/1/98) and "What If You Ran Your Library Like a Bookstore?" (American Libraries, 3/98) kicked up a controversy about the viability of libraries. Ironically, these days it's the book business that has an aura of crisis and gloom, while visits to libraries are surging. Over two billion…

  6. Skin laser treatments enhancing transdermal delivery of ALA.

    PubMed

    Gómez, Clara; Costela, Ángel; García-Moreno, Inmaculada; Llanes, Felipe; Teijón, José M; Blanco, M Dolores

    2011-01-01

    Drug delivery across skin has been limited due to barrier properties of the skin, especially those of the stratum corneum (SC). Use of the laser radiation has been suggested for the controlled removal of the SC. The purpose of this study was to study in vitro the influence of infrared radiation from the erbium:yttrium-aluminum-garnet (Er:YAG) laser (λ = 2940  nm), and visible from the 2nd harmonic of a neodymium:yttrium-aluminum-garnet (Nd:YAG) laser (λ = 532  nm) on transdermal delivery of 5-aminolevulinic acid (ALA). Pinna skin of the inner side of rabbit ear was used for skin permeation. The light sources were an Er:YAG laser (Key III Plus KaVo) and a Q-switched Nd:YAG laser (Lotis TII SL-2132). Permeation study, morphological and structural skin examination by histology and differential scanning calorimetry (DSC) were carried out. Permeation profiles and histological observations obtained after irradiation with infrared and visible laser radiation differed due to different biophysical effects on irradiated skin. Wavelength of 2940  nm required lower energy contribution to produce the same level of permeation than visible radiation at 532  nm. Structural analysis by DSC shows a selective impact on the lipidic structure. Laser pretreatment enhanced the delivery of ALA trough the skin by SC ablation. PMID:20589948

  7. Relationship between occlusal plane and ala-tragus line in dentate individuals: A Clinical pilot study.

    PubMed

    Nayar, Sanjna; Bhuminathan, S; Bhat, Wasim Manzoor; Mahadevan, R

    2015-04-01

    Many methods have been used to establish the occlusal plane in complete denture prosthodontics. However, no single method seems to be fully accepted. Anteriorly, esthetic considerations help define the occlusal plane, and posteriorly the tongue, retromolar pad, and Stenson's duct are considered. Some dentists bisect the space between the residual ridges. The technique of using the ala-tragus line (Camper's line) to establish the occlusal plane is well documented. However, definitions of the ala-tragus line cause confusion, because the exact points of reference do not agree. For example, the glossary of prosthodontic terms states that the ala-tragus line runs from the inferior border of the ala of the nose to the superior border of the tragus of the ear while Spratley' describes it as running from the center of the ala to the center of the tragus. This article concerns us the exact relationship between the occlusal plane and ala-tragus line in dentate individuals. PMID:26015765

  8. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration.

    PubMed

    Eisenberg, David M; Harris, Eric S J; Littlefield, Bruce A; Cao, Shugeng; Craycroft, Jane A; Scholten, Robert; Bayliss, Peter; Fu, Yanling; Wang, Wenquan; Qiao, Yanjiang; Zhao, Zhongzhen; Chen, Hubiao; Liu, Yong; Kaptchuk, Ted; Hahn, William C; Wang, Xiaoxing; Roberts, Thomas; Shamu, Caroline E; Clardy, Jon

    2011-01-01

    While the popularity of and expenditures for herbal therapies (aka "ethnomedicines") have increased globally in recent years, their efficacy, safety, mechanisms of action, potential as novel therapeutic agents, cost-effectiveness, or lack thereof, remain poorly defined and controversial. Moreover, published clinical trials evaluating the efficacy of herbal therapies have rightfully been criticized, post hoc, for their lack of quality assurance and reproducibility of study materials, as well as a lack of demonstration of plausible mechanisms and dosing effects. In short, clinical botanical investigations have suffered from the lack of a cohesive research strategy which draws on the expertise of all relevant specialties. With this as background, US and Chinese co-investigators with expertise in Traditional Chinese Medicine (TCM), botany, chemistry and drug discovery, have jointly established a prototype library consisting of 202 authenticated medicinal plant and fungal species that collectively represent the therapeutic content of the majority of all commonly prescribed TCM herbal prescriptions. Currently housed at Harvard University, the library consists of duplicate or triplicate kilogram quantities of each authenticated and processed species, as well as "detanninized" extracts and sub-fractions of each mother extract. Each species has been collected at 2-3 sites, each separated geographically by hundreds of miles, with precise GPS documentation, and authenticated visually and chemically prior to testing for heavy metals and/or pesticides contamination. An explicit decision process has been developed whereby samples with the least contamination were selected to undergo ethanol extraction and HPLC sub-fractionation in preparation for high throughput screening across a broad array of biological targets including cancer biology targets. As envisioned, the subfractions in this artisan collection of authenticated medicinal plants will be tested for biological activity

  9. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation — Rationale, methods and preliminary results from a Sino-American collaboration☆

    PubMed Central

    Eisenberg, David M.; Harris, Eric S.J.; Littlefield, Bruce A.; Cao, Shugeng; Craycroft, Jane A.; Scholten, Robert; Bayliss, Peter; Fu, Yanling; Wang, Wenquan; Qiao, Yanjiang; Zhao, Zhongzhen; Chen, Hubiao; Liu, Yong; Kaptchuk, Ted; Hahn, William C.; Wang, Xiaoxing; Roberts, Thomas; Shamu, Caroline E.; Clardy, Jon

    2011-01-01

    While the popularity of and expenditures for herbal therapies (aka “ethnomedicines”) have increased globally in recent years, their efficacy, safety, mechanisms of action, potential as novel therapeutic agents, cost-effectiveness, or lack thereof, remain poorly defined and controversial. Moreover, published clinical trials evaluating the efficacy of herbal therapies have rightfully been criticized, post hoc, for their lack of quality assurance and reproducibility of study materials, as well as a lack of demonstration of plausible mechanisms and dosing effects. In short, clinical botanical investigations have suffered from the lack of a cohesive research strategy which draws on the expertise of all relevant specialties. With this as background, US and Chinese co-investigators with expertise in Traditional Chinese Medicine (TCM), botany, chemistry and drug discovery, have jointly established a prototype library consisting of 202 authenticated medicinal plant and fungal species that collectively represent the therapeutic content of the majority of all commonly prescribed TCM herbal prescriptions. Currently housed at Harvard University, the library consists of duplicate or triplicate kilogram quantities of each authenticated and processed species, as well as “detanninized” extracts and sub-fractions of each mother extract. Each species has been collected at 2–3 sites, each separated geographically by hundreds of miles, with precise GPS documentation, and authenticated visually and chemically prior to testing for heavy metals and/or pesticides contamination. An explicit decision process has been developed whereby samples with the least contamination were selected to undergo ethanol extraction and HPLC sub-fractionation in preparation for high throughput screening across a broad array of biological targets including cancer biology targets. As envisioned, the subfractions in this artisan collection of authenticated medicinal plants will be tested for biological

  10. In Quest of the Perfect Library

    ERIC Educational Resources Information Center

    Holleran, Andrew

    2007-01-01

    There is a sad truth about college libraries: No matter how attractively designed and cleverly constructed, they cannot disguise a central fact--that the undergraduates in them are seldom there to read books they want to read. The author explains that when he walks through the library at Georgetown University or American University, his heart goes…

  11. What's New in the Library Automation Arena?

    ERIC Educational Resources Information Center

    Breeding, Marshall

    1998-01-01

    Reviews trends in library automation based on vendors at the 1998 American Library Association Annual Conference. Discusses the major industry trend, a move from host-based computer systems to the new generation of client/server, object-oriented, open systems-based automation. Includes a summary of developments for 26 vendors. (LRW)

  12. Multiple Thesauri in Online Library Bibliographic Systems.

    ERIC Educational Resources Information Center

    Mandel, Carol A.

    This report responds to the need for North American libraries to provide computer support for multiple subject lists or controlled vocabularies as they automate separate catalogs using specialized thesauri for certain subject areas, materials, and audiences in addition to their main library catalogs. The focus of the report is the integration of…

  13. Libraries, Patrons, and E-Books

    ERIC Educational Resources Information Center

    Zickuhr, Kathryn; Rainie, Lee; Purcell, Kristen; Madden, Mary; Brenner, Joanna

    2012-01-01

    This report explores the world of e-books and libraries, where libraries fit into these book-consumption patterns of Americans, when people choose to borrow their books and when they choose to buy books. It examines the potential frustrations e-book borrowers can encounter when checking out digital titles, such as long wait lists and compatibility…

  14. The Ideas of Henry Jenkins and Libraries

    ERIC Educational Resources Information Center

    Anderson, Byron

    2008-01-01

    Henry Jenkins, director of the Comparative Media Studies Program at the Massachusetts Institute of Technology and keynote speaker at the 2007 American Library Association's "Gaming, Learning and Libraries Symposium" in Chicago is a visionary leader in the areas of new media and media convergence. In a white paper on digital media and learning…

  15. In vivo study of ALA PLGA nanoparticles-mediated PDT for treating cutaneous squamous cell carcinoma

    NASA Astrophysics Data System (ADS)

    Wang, Xiaojie; Shi, Lei; Huang, Zheng; Wang, Xiuli

    2014-09-01

    Background: Squamous cell carcinoma (SCC) is a common skin cancer and its treatment is still a challenge. Although topical photodynamic therapy (PDT) is effective for treating in situ and superficial SCC, the effectiveness of topical ALA delivery to thick SCC can be limited by its bioavailability. Polylactic-co-glycolic acid nanopartieles (PLGA NPs) might provide a promising ALA delivery strategy. The aim of this study was to evaluate the efficacy of ALA PLGA NPs PDT for the treatment of cutaneous SCC in a mouse model. Methods: ALA loaded PLGA NPs were prepared and characterized. The therapeutic efficacy of ALA PLGA NP mediated PDT in treating UV-induced cutaneous SCC in the mice model were examined. Results: In vivo study showed that ALA PLGA NPs PDT were more effective than free ALA of the same concentration in treating mouse cutaneous SCC. Conclusion: ALA PLGA NPs provides a promising strategy for delivering ALA and treating cutaneous SCC.

  16. Callpath Library

    SciTech Connect

    Gamblin, T.

    2013-11-09

    The "Callpath Library" is a software abstraction layer over a number of stack tracing utilities. It allows tool develoopers to conveniently represent and mNipulate call paths gathered fro U. Wisconsin's Stackwalker API and GNU Backtrace.

  17. Academic Libraries

    ERIC Educational Resources Information Center

    Library Journal, 1970

    1970-01-01

    Building data is given for the following academic libraries: (1) Rosary College, River Forest, Illinois; (2) Abilene Christian College, Abilene, Texas; (3) University of California, San Diego, La Jolla, California. (MF)

  18. Digital Libraries.

    ERIC Educational Resources Information Center

    Fox, Edward A.; Urs, Shalini R.

    2002-01-01

    Provides an overview of digital libraries research, practice, and literature. Highlights include new technologies; redefining roles; historical background; trends; creating digital content, including conversion; metadata; organizing digital resources; services; access; information retrieval; searching; natural language processing; visualization;…

  19. The Right to Read and the Nation's Libraries.

    ERIC Educational Resources Information Center

    Public Library Association, Chicago, IL.

    Edited jointly by the Right to Read Committees of the American Association of School Librarians (AASL), Children's Services Division (CSD), and Public Library Association (PLA) of the American Library Association these papers outline the original aims of the Right to Read Program and demonstrate their translation into an effort to bring books and…

  20. 5-ALA-assisted photodynamic therapy in canine prostates

    NASA Astrophysics Data System (ADS)

    Sroka, Ronald; Muschter, Rolf; Knuechel, Ruth; Steinbach, Pia; Perlmutter, Aaron P.; Martin, Thomas; Baumgartner, Reinhold

    1996-05-01

    Photodynamic therapy (PDT) and interstitial thermotherapy are well known treatment modalities in urology. The approach of this study is to combine both to achieve a selective treatment procedure for benign prostatic hyperplasia (BPH) and prostate carcinoma. Measurements of thy in-vivo pharmacokinetics of 5-ALA induced porphyrins by means of fiber assisted ratiofluorometry showed a maximum fluorescence intensity at time intervals of 3 - 4 h post administration. Fluorescence microscopy at that time showed bright fluorescence in epithelial cells while in the stroma fluorescence could not be observed. Interstitial PDT using a 635-nm dye laser with an irradiation of 50 J/cm2 resulted in a nonthermic hemorrhagic lesion. The lesion size did not change significantly when an irradiation of 100 J/cm2 was used. The usefulness of PDT for treating BPH as well as prostate carcinoma has to be proven in further studies.

  1. Standards for British Libraries.

    ERIC Educational Resources Information Center

    Vaughan, Anthony

    1982-01-01

    Reviews developments in British library standards since 1971, highlighting types of standards, public libraries, academic libraries (university, polytechnic, college), school libraries, and special libraries (hospital and health sciences, prison, subject specializations). Thirty-nine references are cited. (EJS)

  2. How Children's Books Distort the Asian American Image. Criteria for Analyzing Books on Asian Americans. Survey of Childrens' Books: Chinese American, Japanese American, Korean American, Vietnamese American, General

    ERIC Educational Resources Information Center

    Bridge, 1976

    1976-01-01

    Eleven Asian American book reviewers were asked by the Council on Interracial Books for Children to find, read, and analyze all childrens books on Asian American themes currently in print or in use in schools and libraries. The major conclusion was that, with one or perhaps two exceptions, the 66 books reviewed are racist, sexist, and elitist.…

  3. Structure of the interface between ErAs, a cubic semimetal and AlAs, a tetrahedral semiconductor

    SciTech Connect

    Tarnow, E.

    1995-06-15

    Using {ital ab} {ital initio} local density calculations, the atomic structure of the (100) interface between ErAs, a semimetal with the sodium-chloride (SC) structure and AlAs, a semiconductor with the zinc-blende (ZB) structure is investigated. Several findings emerge: (1) Eight different high symmetry SC/ZB interfaces are identified and classified. (2) Several low energy interfaces, and combinations thereof, are found for epitaxial growth and for small superlattices. The energies of these interfaces change during epitaxy pointing to importance of kinetics. Calculated structural energies and Er {l_angle}100{r_angle} placements are compared with experimental Rutherford backscattering measurements. (3) The AlAs ZB structure buckles the first ErAs SC layer. There is a strong correlation between the amount of buckling induced in a substrate SC layer and the energy required to add another SC layer. (4) For small superlattices a complete ZB or SC arrangement, removing the SC/ZB interfaces altogether, is sometimes energetically preferred. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  4. The Relationship between Library Anxiety and Reading Ability.

    ERIC Educational Resources Information Center

    Jiao, Qun G.; Onwuegbuzie, Anthony J.

    This study examined the relationship between reading comprehension and reading vocabulary and five dimensions of library anxiety (i.e., barriers with staff, affective barriers, comfort with the library, knowledge of the library, and mechanical barriers). Participants were 45 African-American graduate students from various disciplines who were…

  5. Reading Ability as a Predictor of Library Anxiety.

    ERIC Educational Resources Information Center

    Jiao, Qun G.; Onwuegbuzie, Anthony J.

    2003-01-01

    Examined the relationship between reading comprehension, reading vocabulary, and five dimensions of library anxiety: barriers with staff, affective barriers, comfort with the library, knowledge of the library, and mechanical barriers. Participants were 45 African American graduate students from various disciplines who were given the Library…

  6. Enhanced photodynamic efficacy of PLGA-encapsulated 5-ALA nanoparticles in mice bearing Ehrlich ascites carcinoma

    NASA Astrophysics Data System (ADS)

    Shaker, Maryam N.; Ramadan, Heba S.; Mohamed, Moustafa M.; El khatib, Ahmed M.; Roston, Gamal D.

    2014-10-01

    Nanoparticles (NPs) fabricated from the biodegradable copolymer poly(lactic- co-glycolic acid) (PLGA) were investigated as a drug delivery system to enhance the photodynamic efficacy of 5-aminolevulinic acid (5-ALA) in mice bearing Ehrlich ascites carcinoma. The PLGA-encapsulated 5-ALA NPs were prepared using binary organic solvent diffusion method and characterized in terms of shape and particle size. The in vivo photodynamic efficiency in Ehrlich ascites-bearing mice was studied. The obtained particles were uniform in size with spherical shape of mean size of 249.5 nm as obtained by particle size analyzer and the in vitro release studies demonstrated a controlled release profile of 5-ALA. Tumor-bearing mice injected with PLGA-encapsulated 5-ALA NPs exhibited significantly smaller mean tumor volume, increased tumor growth delay compared with the control group and the group injected with free 5-ALA during the time course of the experiment. Histopathological examination of tumor from mice treated with PLGA-encapsulated 5-ALA NPs showed regression of tumor cells, in contrast to those obtained from mice treated with free 5-ALA. The results indicate that PLGA-encapsulated 5-ALA NPs are a successful delivery system for improving photodynamic activity in the target tissue.

  7. ALA-PDT inhibits proliferation and promotes apoptosis of SCC cells through STAT3 signal pathway.

    PubMed

    Qiao, Li; Mei, Zhusong; Yang, Zhiyong; Li, Xinji; Cai, Hong; Liu, Wei

    2016-06-01

    Previous studies suggest that apoptosis of carcinoma cells led by photodynamics is mainly intrinsic apoptosis, but whether the extrinsic pathway is involved in the treatment of carcinoma by photodynamic therapy is not confirmed. This research investigated the effect of ALA-PDT on the proliferation and apoptosis of SCC cell A431 and COLO-16, and discussed the role played by JAK/STAT3 signal pathway in this process. Our data showed that the expression levels STAT3 and p-STAT3 protein in the cancer tissue are higher than the corresponding adjacent tissue to carcinoma. The expression level of p-STAT3 in cancerous tissue has a correlation with the tumor size and tissue histopathological differentiation. ALA-PDT could inhibit proliferation of A431 and COLO-16 cells, STAT3 knock down could enhance ALA-PDT's inhibition of cell proliferation, and promote apoptosis induced by ALA-PDT. On the other hand, overexpression of STAT3 has the opposite effect. In addition, ALA-PDT can weaken the protein expression of STAT3 and its target gene Bcl-2 mRNA, and ALA-PDT can strengthen the protein expression of STAT3's target gene Bax mRNA. Overexpression of STAT3 can offset the effect on Bcl-2 and Bax by ALA-PDT; on the other hand, STAT3 knocking down can strengthen ALA-PDT's effect on Bcl-2 and Bax. PMID:26805005

  8. Building a Digital Library: With Comments on Cooperative Grant Projects and the Goals of a Digital Library.

    ERIC Educational Resources Information Center

    Peterson, Elaine

    2001-01-01

    Discussion of digital libraries focuses on the development of an image database of Native Americans that would be searchable on the Web. Describes a grant from the Institute of Museum and Library Services that Montana State University used for the project and discusses collaboration between libraries, museums, and archives. (LRW)

  9. Inducible l-Alanine Exporter Encoded by the Novel Gene ygaW (alaE) in Escherichia coli ▿

    PubMed Central

    Hori, Hatsuhiro; Yoneyama, Hiroshi; Tobe, Ryuta; Ando, Tasuke; Isogai, Emiko; Katsumata, Ryoichi

    2011-01-01

    We previously isolated a mutant hypersensitive to l-alanyl-l-alanine from a non-l-alanine-metabolizing Escherichia coli strain and found that it lacked an inducible l-alanine export system. Consequently, this mutant showed a significant accumulation of intracellular l-alanine and a reduction in the l-alanine export rate compared to the parent strain. When the mutant was used as a host to clone a gene(s) that complements the dipeptide-hypersensitive phenotype, two uncharacterized genes, ygaW and ytfF, and two characterized genes, yddG and yeaS, were identified. Overexpression of each gene in the mutant resulted in a decrease in the intracellular l-alanine level and enhancement of the l-alanine export rate in the presence of the dipeptide, suggesting that their products function as exporters of l-alanine. Since ygaW exhibited the most striking impact on both the intra- and the extracellular l-alanine levels among the four genes identified, we disrupted the ygaW gene in the non-l-alanine-metabolizing strain. The resulting isogenic mutant showed the same intra- and extracellular l-alanine levels as observed in the dipeptide-hypersensitive mutant obtained by chemical mutagenesis. When each gene was overexpressed in the wild-type strain, which does not intrinsically excrete alanine, only the ygaW gene conferred on the cells the ability to excrete alanine. In addition, expression of the ygaW gene was induced in the presence of the dipeptide. On the basis of these results, we concluded that YgaW is likely to be the physiologically most relevant exporter for l-alanine in E. coli and proposed that the gene be redesignated alaE for alanine export. PMID:21531828

  10. Colonial American Literature: A Guide to Resources.

    ERIC Educational Resources Information Center

    Van Noate, Judith, Comp.

    This handout is a guide to library resources in the J. Murrey Atkins Library at the University of North Carolina-Charlotte for the study of colonial American literature. The guide is intended to help readers find sources of criticism on colonial and revolutionary literature. It explains important reference sources in the Atkins library reference…

  11. Evaluation of ALA-induced PpIX as a photosensitizer for PDT in cats

    NASA Astrophysics Data System (ADS)

    Lucroy, Michael D.; Edwards, Benjamin F.; Peavy, George M.; Krasieva, Tatiana B.; Griffey, Stephen M.; Madewell, Bruce R.

    1998-07-01

    Given exogenously, ALA defeats intrinsic regulatory feedback mechanisms allowing intracellular accumulation of protoporphyrin IX (PpIX), a highly efficient photosensitizer. In vivo, PpIX synthesis in neoplastic mammary tissues averages 20-fold higher than in normal mammary tissues. PpIX is retained intracellularly, unlike perivascular localization of other photosensitizers, and it is then cleared quickly from the body. In vitro, ALA induced PpIX production in our laboratory in 6 cell lines tested, including an established feline kidney cell line and dermal fibroblasts from primary skin biopsy explant, resulting in photosensitization. Fluorescent microscopy confirmed PpIX production in skin adnexae following ALA administration in a normal cat. To evaluate toxicity, three cats were treated with a single i.v. dose of ALA (either 100, 200, of 400 mg/kg) and followed for 7 days. Cats receiving 100 or 200 mg/kg ALA i.v. had elevated liver enzymes and bilirubin within 24 hours. Histopathology revealed hydropic changes in the liver and renal fibrosis. The cat receiving 400 mg/kg ALA intravenously had cutaneous flush, bradycardia and apnea associated with ALA administration; within 24 hours the cat was lethargic, anorectic and icteric. ALT, AST and bilirubin concentrations had increased significantly. At necropsy the liver had a prominent lobular pattern; histopathology revealed severe periportal hepatitis and splenic necrosis. Systemically administered ALA induces PpIX production, but toxicity may preclude its clinical application in the cat. PpIX levels seem to be more time dependent than those dependent at these three ALA doses and they are well beyond the saturation point for adequate PpIX conversion. The literature is scant regarding toxicity associated with parenteral administration of ALA.

  12. School Libraries Count! National Longitudinal Survey of School Library Media Programs

    ERIC Educational Resources Information Center

    American Association of School Librarians (NJ1), 2009

    2009-01-01

    The American Association of School Librarians' (AASL's) School Libraries Count! annual longitudinal survey is an online survey that is open to all elementary and secondary school library media programs to participate. The 2009 survey was launched on January 30, and closed on March 22. AASL has received a high participation rate during the three…

  13. Polygamy and the Public Library: The Establishment of Public Libraries in Utah before 1910

    ERIC Educational Resources Information Center

    Stauffer, Suzanne M.

    2005-01-01

    Utah's libraries were perceived as instruments for "the establishment of a recognized social order" by each successive group that came to power and were often founded as the result of conflict between Mormon culture and the larger American society. On their arrival, Mormons established libraries primarily to provide access to information necessary…

  14. America's Star Libraries

    ERIC Educational Resources Information Center

    Lyons, Ray; Lance, Keith Curry

    2009-01-01

    "Library Journal"'s new national rating of public libraries, the "LJ" Index of Public Library Service, identifies 256 "star" libraries. It rates 7,115 public libraries. The top libraries in each group get five, four, or three Michelin guide-like stars. All included libraries, stars or not, can use their scores to learn from their peers and improve…

  15. Molecular structures of two crystalline forms of the cyclic heptapeptide antibiotic ternatin, cyclo[-beta-OH-D-Leu-D-Ile-(NMe)Ala-(NMe)Leu-Leu-(NMe)Ala-D-(NMe)Ala-].

    PubMed

    Miller, R; Galitsky, N M; Duax, W L; Langs, D A; Pletnev, V Z; Ivanov, V T

    1993-12-01

    The crystal structures of two solvated forms of ternatin, cyclo[-beta-OH-D-Leu-D-Ile-(NMe)Ala-(NMe)Leu-Leu-(NMe)Ala-D-(NMe)Ala-] are reported. The first crystallizes with two molecules of peptide and one of dioxane in the asymmetric unit: P2(1)2(1)2(1), a = 11.563(1), b = 21.863(2), c = 36.330(4) A. The second crystallizes with two molecules of peptide and one of water in the asymmetric unit: P2(1)2(1)2(1), a = 14.067(2), b = 16.695(1), c = 36.824(6) A. N-Methylation of four of the seven residues of ternatin appears to reduce the number of low-energy conformations the molecule can assume. The same H-bonded macrocyclic ring conformation is adopted by the backbone of each of the four molecules observed here. All the amino-acid side chains, with the exception of D-Ile2, have similar orientations in each of the four conformers. The heptapeptide macrocycle is characterized by: (i) a cis peptide between (NMe)Ala3 and (NMe)Leu4, (ii) a type II beta-bend, involving residues Leu5-(NMe)Ala6-D-(NMe)Ala7-beta-OH-D-Leu1, stabilized by two H-bonds, N1-->O5 and N5-->O1, between Leu5 and beta-OH-D-Leu1 residues, (iii) a third intramolecular H-bond, observed in each of the four molecules, between the hydroxyl group of beta-OH-D-Leu1 and the carbonyl oxygen of D-Ile2. PMID:8307686

  16. Expanded roles for hospital libraries: a direction for successful change.

    PubMed Central

    Reel, L B

    1985-01-01

    Hospitals are changing to cope with a new environment and their libraries are changing with them. We demonstrate that hospital librarians can influence the change process and that expanding the role of the library is one option. Four case reports are presented to illustrate generic problems and how each library has coped with them. The issues facing hospital libraries today are viewed within the broader perspective of the American health care system. PMID:3978296

  17. Public Libraries

    ERIC Educational Resources Information Center

    Library Journal, 1972

    1972-01-01

    Building data is given for the following public libraries: New York, New York; Blue Island, Illinois; Corte Madera, California; Muskogee, Oklahoma: Charlotte, North Carolina; Washington, D.C.; Houston, Texas; Albermarle, North Carolina; Spokane, Washington; and Hemet, California. (Author/NH)

  18. Library Venturing.

    ERIC Educational Resources Information Center

    Wilson, H. Donald

    1986-01-01

    There is opportunity for service and profit to imaginative libraries organizing to provide new forms of knowledge. Librarians as entrepreneurs must learn venture management and finance. Available assistance includes growing entrepreneural understanding in large institutions; family and friends; private wealth-seeking investment; new business…

  19. Library Handbook.

    ERIC Educational Resources Information Center

    Cupp, Christian M., Ed.

    The purpose of this handbook is to help students, staff, and community patrons attain a reasonable degree of skill in using the Southeastern Community College Library effectively. The first section instructs the user on how to find information. A discussion of the card catalog and its use provides examples of catalog cards, reviews the…

  20. Library Environment.

    ERIC Educational Resources Information Center

    Computers in Libraries, 1993

    1993-01-01

    This special section includes two articles that review products and services for the automated library environment. Highlights include ergonomic products; products for visually, hearing-, and speech-impaired users; analog film recorders; computer filters; document imaging systems; electric filing systems; and printers. A list of vendors is…

  1. Native American Languages: Subject Guide.

    ERIC Educational Resources Information Center

    Martin, Joyce, Comp.

    This document is an eleven-page supplemental subject guide listing reference material that focuses on Native American languages that is not available in the Labriola National American Indian Data Center in the Arizona State University, Tempe (ASU) libraries. The guide is not comprehensive but offers a selective list of resources useful for…

  2. The role of DAMPS in ALA-PDT for skin squamous cell carcinoma (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Wang, Xiuli; Wang, Xiaojie; Ji, Jie; Zhang, Haiyan; Shi, Lei

    2016-03-01

    5-Aminolevulinic acid mediated photodynamic therapy (ALA-PDT) is an established local approach for skin squamous cell carcinoma. It is believed that dangerous signals damage-associated molecular patterns (DAMPs) play an important role in ALA-PDT. In this study, we evaluated in vitro and in vivo expressions of major DAMPs, calreticulin (CRT), heat shock proteins 70 (HSP70), and high mobility group box 1 (HMGB1), induced by ALA-PDT using immunohistochemistry, western blot, and ELISA in a squamous cell carcinoma (SCC) mouse model. The role of DAMPs in the maturation of DCs potentiated by ALA-PDT-treated tumor cells was detected by FACS and ELISA. Our results showed that ALA-PDT enhanced the expression of CRT, HSP70, and HMGB1. These induced DAMPs played an important role in activating DCs by PDT-treated tumor cells, including phenotypic maturation (upregulation of surface expression of MHC-II, CD80, and CD86) and functional maturation (enhanced capability to secrete IFN-γ and IL-12). Furthermore, injecting ALA-PDT-treated tumor cells into naïve mice resulted in complete protection against cancer cells of the same origin. Our findings indicate that ALA-PDT can upregulate DAMPs and enhance tumor immunogenicity, providing a promising strategy for inducing a systemic anticancer immune response.

  3. Molecular mechanisms associated with ALA-PDT of brain tumor cells

    NASA Astrophysics Data System (ADS)

    Alqawi, Omar; Espiritu, Myrna; Singh, Gurmit

    2009-06-01

    Previous studies have shown that low-dose PDT using 5-aminolevulinic acid (ALA)-induced photoporphyrin IX (PpIX) can induce apoptosis in tumor cells without causing necrosis. In this study we investigated the molecular mechanisms associated with apoptosis after ALA-PDT treatment in two brain glioma cell lines: human U87, and rat CNS-1cells. We used high energy light at a short time (acute PDT) and low energy light at a long time of exposure (metronomic PDT) to treat both cell lines. The cells were treated with 0.25 mM ALA at 5 joules for energy. We found that CNS-1 cells were more resistant to ALA-PDT than U87 cells when treated by both acute and metronomic PDT. To screen possible apoptosis mechanisms associated with acute and metronomic PDT, microarray analysis of gene expression was performed on RNA from glioblastoma cells treated with either acute or metronomic ALA-PDT. Within the set of genes that were negatively or positively regulated by both treatments are tumor necrosis factor receptors. The expression of TNF receptors was investigated further by RT-PCR and western blotting. The apoptosis mechanism of the cell death occurred through different pathways including BCL-2 and TNF receptors, and in part caused by cleaving caspase 3. Interestingly, metronomic ALA-PDT inhibited the expression of LTβR and the transcription factor NFκB. This inhibition was ALA concentration dependent at low concentrations.

  4. The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans.

    PubMed

    Zhang, Z; Zhao, Y; Wang, X; Lin, R; Zhang, Y; Ma, H; Guo, Y; Xu, L; Zhao, B

    2016-04-20

    Food-derived bioactive peptides may have various physiological modulatory and regulatory functions and are now being studied extensively. Recently, the novel dipeptide Tyr-Ala was isolated from hydrolyzed maize protein. Tyr-Ala significantly prolonged the lifespan of wild-type Caenorhabditis elegans and extended the nematode healthspan and lifespan during heat/oxidative stress. Compared with its constituent amino acids, Tyr-Ala was more efficient in enhancing stress resistance. Further studies demonstrated that the significant longevity-extending effects of Tyr-Ala on Caenorhabditis elegans were attributed to its in vitro and in vivo free radical-scavenging effects, in addition to its ability to up-regulate stress resistance-related proteins, such as SOD (Superoxide Dismutase)-3 and HSP (Heat Shock Protein)-16.2. Real-time PCR results showed that the up-regulation of aging-associated genes, such as daf-16, sod-3, hsp-16.2 and skn-1, also contributed to the stress-resistance effect of Tyr-Ala. These results indicate that the novel dipeptide Tyr-Ala can protect against external stress and thus extend the lifespan and healthspan of Caenorhabditis elegans. Thereby, Tyr-Ala could be used as a potential medicine in anti-aging research. PMID:26987062

  5. Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease.

    PubMed

    Kazemi, E; Moradi, M-T; Yari, K; Mousavi, S A R; Kahrizi, D

    2015-01-01

    Generalized aggressive periodontitis (GAP) is a subtype of periodontal diseases that characterized by rapid destruction of periodontal supporting tissues. The MnSOD Val-9Ala mutation of manganese superoxide dismutase gene (MnSOD Val-9Ala) and its correlation with periodontal diseases has been studied in different populations. The purpose of this study was to investigate the possible association of MnSODVal-9Ala polymorphism with periodontitis disease in sample of GAP patients in Iran for the first time. Following a GAP examination, 50 GAP patients and 100 healthy individuals were recruited. Genomic DNA was extracted from peripheral blood leukocytes and the MnSODVal-9Ala polymorphismwas detected using PCR-RFLP method. The frequency of Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 25, 66 and 9%, respectively. In periodontitis patients, frequencies were as Ala/Ala (12%), Ala/Val (50%) and Val/Val (38%) genotypes. There was a significant positive association between distribution of MnSOD Val-9Ala genotypes and the risk of periodontitis disease (p<0.05). Our results indicated that MnSOD Val-9Ala gene polymorphism has a positive association with the risk of periodontitis disease. PMID:26718428

  6. Five-Year Plan for Development of Library Services in Salt Lake County, 1973-1977.

    ERIC Educational Resources Information Center

    Schuurman, Guy

    A five-year plan for the Salt Lake County Library System is presented to meet the complex needs of patrons and to comply with American Library Association's "Minimum Standards for Public Library Systems" (1966). A new main library building is planned to house the main collection, and enlarged nonprint collection, and audiovisual and conference…

  7. Libraries as Agencies of Culture. Print Culture History in Modern America.

    ERIC Educational Resources Information Center

    Augst, Thomas, Ed.; Wiegand, Wayne A., Ed.

    2001-01-01

    This theme issue contains the following articles on libraries as agencies of culture: (1) "American Libraries and Agencies of Culture" (Thomas Augst); (2) "The Sound of the Civic: Reading Noise at the New York Public Library" (Ari Kelman); (3) "High Culture, Low Culture: The Singular Duality of the Library of Congress" (Elizabeth Jane Aikin); (4)…

  8. Library Networks in Less-Developed Countries: Two Argentine Cases and Some Observations.

    ERIC Educational Resources Information Center

    Tang, Donna Taxco

    As an American Library Association/USIA International Library Fellow in Argentina from March to September 1989, the author worked with the Argentine National Protective Commission for People's Libraries. Included in her assignment was a charge "to assist in the development of a popular libraries network in Patagonia," the southernmost region of…

  9. Age-dependent dichotomous effect of superoxide dismutase Ala16Val polymorphism on oxidized LDL levels

    PubMed Central

    Kanoni, Stavroula; Panagiotakos, Demosthenes B.; Louizou, Eirini; Grigoriou, Efi; Chrysohoou, Christina; Pitsavos, Christos; Stefanadis, Christodoulos

    2008-01-01

    We investigated the association between superoxide dismutase (SOD) Ala16Val polymorphism and the levels of oxidized LDL lipoprotein-C (ox-LDL-C) in two age-different Greek cohorts. Four hundred fifteen middle-aged (n = 147 females: 43.2 ± 13 years, n = 268 males: 43.3 ± 14 years) Caucasian Greek subjects consisted the middle aged cohort. One hundred seventy five elderly (n = 88 females: 79.9 ± 4 years; n = 87 males: 80.6 ± 4 years) were selected from the elderly cohort. Genotype data were obtained for all of them. Multiple linear regression analysis, stratified by gender and adjusted for age, smoking habits and body mass index as covariates, showed higher ox-LDL-C levels for the middle aged men with the Val/Val genotype, compared to the other allele (Ala/Ala and Ala/Val) carriers (65.9 ± 25.7 vs. 55.7 ± 20.5 mg/dl; standardized β coefficient = 0.192, P = 0.012). On the contrary, elderly women with the Val/Val genotype occurred with lower ox-LDL-C levels compared to the Ala/Ala or Ala/Val genotype (74.2 ± 22.1 vs. 86.5 ± 26.6 mg/dl; standardized β coefficient = -0.269, P = 0.015). The same trend was also recorded in elderly men, however without reaching statistical significance (standardized β coefficient = -0.187, P = 0.077). Moreover, elderly men and women with the Ala/Ala or Ala/Val genotype presented higher triglycerides levels compared to Val/Val (women: 145.2 ± 68.7 vs. 114.3 ± 34.3 mg/dl, P = 0.027; men: 147.8 ± 72.4 vs. 103.7 ± 38.0 mg/dl, P = 0.002). Additionally, middle aged men with the Val/Val genotype had higher HDL-C levels compared to the Ala allele carriers. The results suggest that SOD Ala16Val polymorphism is an age-dependent modulator of ox-LDL-C levels in middle-aged men and elderly women. PMID:18305395

  10. American Pharmacists Association

    MedlinePlus

    ... THE APhA FOUNDATION PHARMACY LIBRARY BUYERS GUIDE 2215 Constitution Avenue NW, Washington, DC 20037 © 2016 American Pharmacists ... NEW PRACTITIONER NETWORK ELECTIONS ANNUAL MEETING & EXPOSITION JOINT FEDERAL PHARMACY SEMINAR AWARDS JOIN APhA WHY JOIN APhA? ...

  11. Asians and Asian Americans.

    ERIC Educational Resources Information Center

    San Francisco Unified School District, CA.

    This is a selected bibliography of some good and some outstanding audio-visual educational materials in the library of the Educational Materials Bureau, Audio-Visual Education Section, that may be considered of particular interest in the study of Asians and Asian-Americans. The bibliography is arranged alphabetically within the following subject…

  12. Native Americans: Subject Guide.

    ERIC Educational Resources Information Center

    Bonanni, Mimmo; Etter, Patricia A.

    This annotated subject guide lists reference material that deals with Native Americans and is available in the Arizona State University Libraries. Entries were published 1933-98, but mostly in the 1980s-90s. The guide is not comprehensive, but rather a selective list of resources useful for researching a topic in a variety of fields. The guide…

  13. Library Automation and Library Education.

    ERIC Educational Resources Information Center

    Drabenstott, Jon, Ed.

    1987-01-01

    Several consultants address the issue of competencies required of professional librarians for the effective management of the automation process. Highlights include formal and professional ongoing education and the need for technical training and problem solving skills to enable librarians to evaluate and develop library systems effectively.…

  14. Symposium on Presidential Libraries.

    ERIC Educational Resources Information Center

    Relyea, Harold C.; And Others

    1994-01-01

    Includes five articles that discuss presidential libraries. Highlights include an overview of the development of the federal presidential library system; the Ronald Reagan library; the Richard Nixon library archives; access at the Gerald Ford library; and computerizing the Jimmy Carter library. (LRW)

  15. Turkish Libraries: Historical Context.

    ERIC Educational Resources Information Center

    Cakin, Irfan

    1984-01-01

    Summary of the development of libraries in Turkey highlights the existence of libraries in the ninth century, the Shamssaddin Altunaba Medrese library in Konya, libraries established during the Ottoman era, reports to reform libraries (1869-70, 1909), and reports and library developments attributed to the Republican Era beginning in 1923. (EJS)

  16. Library Research and Statistics.

    ERIC Educational Resources Information Center

    Lynch, Mary Jo; St. Lifer, Evan; Halstead, Kent; Fox, Bette-Lee; Miller, Marilyn L.; Shontz, Marilyn L.

    2001-01-01

    These nine articles discuss research and statistics on libraries and librarianship, including libraries in the United States, Canada, and Mexico; acquisition expenditures in public, academic, special, and government libraries; price indexes; state rankings of public library data; library buildings; expenditures in school library media centers; and…

  17. New developments in fluorescence detection of ALA-induced protoporphyrin IX for cancer localization

    NASA Astrophysics Data System (ADS)

    Stepp, Herbert G.; Baumgartner, Reinhold; Betz, Christian; Bise, Karl; Brand, P.; Gamarra, Fernando; Haeussinger, Karl; Hillemanns, Peter; Huber, Rudolf M.; Knuechel, Ruth; Kriegmair, M.; Leunig, Andreas; Pichler, J.; Rick, Kai; Schulz, H.; Stanzel, F.; Stocker, Susanne; Wagner, Simon; Weigandt, H.

    1997-12-01

    After the very promising clinical results for the detection of bladder cancer in urology, preclinical and clinical studies on aminolevulinic acid (5-ALA) induced protoporphyrin IX (PPIX) are preformed in various disciplines now. This paper provides a brief overview of the progress on 5-ALA assisted fluorescence diagnosis in urology, pulmonology, neurosurgery, gynecology and ENT performed in collaboration with the Laser Research Laboratory at the Department of Urology of the Ludwig-Maximilians-University in Munich. Five-ALA can be applied either topically or systemically to induce an intracellular accumulation of fluorescing PPIX. With appropriate dosage of 5-ALA, malignant tissue can be stained selectively, and irradiation with violet light excites a bright red fluorescence of the tumor. Optical properties of the tissue tend to hamper the precise identification and demarcation of suspect areas in fluorescence images. Multicolor remission and fluorescence imaging, therefore, seems to be indispensable for a reliable tumor localization.

  18. Latest results of 5-ALA-based fluorescence diagnosis and other medical disciplines

    NASA Astrophysics Data System (ADS)

    Baumgartner, Reinhold

    1999-02-01

    Preclinical and clinical studies on 5-aminolevulinic acid (5- ALA) induced Protoporphyrin IX (PPIX) are performed in various departments now following promising clinical results for the detection of bladder cancer in urology. This paper provides an overview on the progress of 5-ALA assisted fluorescence diagnosis in urology, pulmonology, neurosurgery, gynecology and ENT coordinated by the Laser Research Laboratory of the Ludwig-Maximilians-University in Munich. 5-ALA can be applied either topically or systematically to induce an intracellular accumulation of fluorescing PPIX. With appropriate dosage of 5-ALA, malignant tissue can be stained selectively, and irradiation with violet light excites a bright red fluorescence of the tumor visible with naked eyes. Optical properties of the tissue tend to hamper the precise identification and demarcation of suspect areas in fluorescence images. Multicolor remission and fluorescence imaging, therefore, should improve tumor localization in future.

  19. Design of PDT protocols using delta-aminolevulinic acid (5ALA)

    NASA Astrophysics Data System (ADS)

    Jacques, Steven L.; He, Xiao-Yan; Gofstein, Gary

    1993-06-01

    The kinetics of protoporphyrin IX (PPIX) synthesis, bioconversion to other metabolic products, and photobleaching were measured in cell cultures after incubation in media containing the metabolic precursor for heme synthesis, (delta) -aminolevulinic acid (5 ALA). A compartmental model described the kinetics in terms of rate constants for the three processes. The maximum amount of PPIX that can be attained in the cells and the concentration of 5 ALA in the medium that obtains this maximum were determined. Using this information, two dosimetry protocols are outlined which both involve complete photobleaching of the PPIX: (1) the classical acute protocol using maximum 5 ALA to produce maximum PPIX and a light treatment of about 0.5 - 1 hr, and (2) a novel prolonged protocol using continuous low-level 5 ALA delivery to produce only slightly elevated PPIX and an extended light exposure time of over 24 hrs.

  20. Conversion of the agent-oriented domain-specific language ALAS into JavaScript

    NASA Astrophysics Data System (ADS)

    Sredojević, Dejan; Vidaković, Milan; Okanović, Dušan; Mitrović, Dejan; Ivanović, Mirjana

    2016-06-01

    This paper shows generation of JavaScript code from code written in agent-oriented domain-specific language ALAS. ALAS is an agent-oriented domain-specific language for writing software agents that are executed within XJAF middleware. Since the agents can be executed on various platforms, they must be converted into a language of the target platform. We also try to utilize existing tools and technologies to make the whole conversion process as simple as possible, as well as faster and more efficient. We use the Xtext framework that is compatible with Java to implement ALAS infrastructure - editor and code generator. Since Xtext supports Java, generation of Java code from ALAS code is straightforward. To generate a JavaScript code that will be executed within the target JavaScript XJAF implementation, Google Web Toolkit (GWT) is used.

  1. 3. Historic American Buildings Survey Photocopy, National Geographic Society Photograph, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Photocopy, National Geographic Society Photograph, 1971 Courtesy, National Geographic Society LIBRARY, 1971 - Townsend House, 2121 Massachusetts Avenue Northwest, Washington, District of Columbia, DC

  2. Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model

    NASA Astrophysics Data System (ADS)

    Wang, Xiaojie; Shi, Lei; Tu, Qingfeng; Wang, Hongwei; Zhang, Haiyan; Wang, Peiru; Zhang, Linglin; Huang, Zheng; Wang, Xiuli; Zhao, Feng; Luan, Hansen

    2015-03-01

    Background: Squamous cell carcinoma (SCC) is a common skin cancer and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted ALA delivery for topical photodynamic therapy (PDT) of cutaneous SCC. Methods: UV-induced cutaneous SCCs were established in hairless mice. ALA loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NPs-induced protoporphyrin IX (PpIX) fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. Results: PLGA NPs could enhance PpIX production in SCC. ALA PLGA NP mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.

  3. First principles predictions of intrinsic defects in aluminum arsenide, AlAs : numerical supplement.

    SciTech Connect

    Schultz, Peter Andrew

    2012-04-01

    This Report presents numerical tables summarizing properties of intrinsic defects in aluminum arsenide, AlAs, as computed by density functional theory. This Report serves as a numerical supplement to the results published in: P.A. Schultz, 'First principles predictions of intrinsic defects in Aluminum Arsenide, AlAs', Materials Research Society Symposia Proceedings 1370 (2011; SAND2011-2436C), and intended for use as reference tables for a defect physics package in device models.

  4. Using a modified nasotracheal tube to prevent nasal ala pressure sore during prolonged nasotracheal intubation.

    PubMed

    Cherng, Chen-Hwan; Chen, Yuan-Wu

    2010-12-01

    Nasotracheal tube induced nasal ala pressure sores or necrosis during prolonged nasotracheal intubation have been reported, and it is a serious but preventable complication. Here we introduce a modified nasotracheal tube to prevent this complication. This modified nasotracheal tube is composed of two parts, an oral endotracheal tube and a proximal part of a preformed nasotracheal tube, which are linked by a connector. The use of this modified nasotracheal tube can prevent nasal ala pressure sores during prolonged nasotracheal intubation. PMID:20809246

  5. ALA-PDT of glioma cell micro-clusters in BD-IX rat brain

    NASA Astrophysics Data System (ADS)

    Madsen, Steen J.; Angell-Petersen, Even; Spetalen, Signe; Carper, Stephen W.; Ziegler, Sarah A.; Hirschberg, Henry

    2006-02-01

    A significant contributory factor to the poor prognosis of patients with glioblastoma multiforme is the inability of conventional treatments to eradicate infiltrating glioma cells. A syngeneic rat brain tumor model is used to investigate the effects of aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) on small clusters of tumor cells sequestered in normal brain. The intrinsic sensitivity of rat glioma cells to PDT was investigated by exposing ALA-incubated cells to a range of radiant exposures and irradiances using 635 nm light. Biodistribution studies were undertaken on tumor-bearing animals in order to determine the tumor selectivity of the photosensitizer following systemic administration (i.p.) of ALA. Effects of ALA-PDT on normal brain and gross tumor were evaluated using histopathology. Effects of PDT on isolated glioma cells in normal brain were investigated by treating animals 48 h after tumor cell implantation: a time when the micro-clusters of cells are protected by an intact blood-brain-barrier (BBB). Rat glioma cells in monolayer are susceptible to ALA-PDT - lower irradiances are more effective than higher ones. Fluorescence microscopy of frozen tissue sections showed that photosensitizer is produced with better than 200:1 tumor-to-normal tissue selectivity following i.p. ALA administration. ALA-PDT resulted in significant damage to both gross tumor and normal brain, however, the treatment failed to prolong survival of animals with newly implanted glioma cells compared to non-treated controls if the drug was delivered either i.p. or directly into the brain. In contrast, animals inoculated with tumor cells pre-incubated in vitro with ALA showed a significant survival advantage in response to PDT.

  6. Strengthening State Library Administrative Agency (Territorial Library).

    ERIC Educational Resources Information Center

    Nieves M. Flores Memorial Library, Agana, Guam.

    This document describes the Basic State Plan Amendments for the Library Services and Construction Act in Guam and the regulations promulgated thereunder. The major projects described under the plan are: Strengthening State Library Administrative Agency; Staff Development; Library Collections, Extention Services, Institutional Libraries; and…

  7. Library Instruction Assessment in Academic Libraries

    ERIC Educational Resources Information Center

    Tancheva, Kornelia; Andrews, Camille; Steinhart, Gail

    2007-01-01

    Determining the best methods of assessment for a library instruction program in a large research university can be a challenging task. Albert R. Mann Library at Cornell University Library has pilot-tested three methods of formative and summative assessment for its library instruction program--attitudinal, outcomes-based, and gap-measure--and…

  8. ALA-based photodynamic therapy in epithelial tumors: in vivo and in vitro models

    NASA Astrophysics Data System (ADS)

    Casas, Adriana; Fukuda, Haydee; Batlle, Alcira

    2000-03-01

    PDT shows considerable potential as a treatment modality for superficial tumors. PDT is based on the accumulation of a photosensitizer in the target tissue. Subsequent illumination with light of an appropriate wavelength provokes a photochemical reaction that results in tumor destruction. Aminolevulinic acid (ALA) is a porphyrin precursor, and its administration result in the endogenous production of phototoxic porphyrins, which has been exploited for PDT. We assessed PDT efficacy employing both in vivo and in vitro models. We used papillomas, keratoacanthomas and in situ carcinomas chemically induced in the skin of SENCAR mice. Using ALA lotion and cream formulations, the maximal amount of porphyrin accumulation in papillomas was 5.52 (mu) g/g tissue. An energy of 150 of J/cm2 was delivered by a copper-dye laser tuned at 630 nm. Microscopically, we found several signs of tissue destruction, more markedly in the upper strata of the in situ carcinomas. Papillomas, characterized by hyperkeratinization, were resistant to PDT. In our in vitro studies, we used an epithelial adenocarcinoma cell line. We tested ALA and its hexyl and methyl derivatives with the aim of increasing porphyrin synthesis. We found that hexyl-ALA was the best compound. When cultures incubated 3 hours in 0.6 mM ALA and 0.1 mM hexyl-ALA respectively were irradiated with 3 J/cm2 only 5 percent of cells survived.

  9. Topical application of ALA PDT for the treatment of moderate to severe acne vulgaris

    NASA Astrophysics Data System (ADS)

    Wang, Xiu-Li; Wang, Hong-Wei; Zhang, Ling-Lin; Su, Lina; Guo, Ming-Xia; Huang, Zheng

    2009-06-01

    Objectives: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)- medicated photodynamic therapy (ALA PDT) for the treatment of moderate to severe acne vulgaris. Methods: Sixteen Chinese patients with moderate to severe facial acne were treated with 1-3 courses of ALA PDT. ALA cream (3%) was freshly prepared and applied to acne lesions for 3-4 h. The lesions were irradiated by a 635 nm diode laser at dose levels of 60 - 80 J/cm2 at 100 mW/cm2. Clinical assessments were conducted before and after treatment up to 3 months. Results: All patents showed response to ALA PDT. Complete clearance was seen in 10 patients (62.5%) and partial clearance in 6 patients (37.5%). One case showed recurrence after complete clearance at 2 months and another two showed recurrence after complete clearance at 3 months. However, the number of new lesions were significantly reduced. Adverse effects were minimal. Conclusions: The results of this preliminary clinical study is encouraging. ALA PDT is a simple, safe and useful therapeutic option for the treatment of moderate to severe acne. Further studies to evaluate the treatment with a larger number of patients and for a longer period of follow-up are needed.

  10. Racial and tissue-specific cancer risk associated with PARP1 (ADPRT) Val762Ala polymorphism: a meta-analysis.

    PubMed

    Pabalan, Noel; Francisco-Pabalan, Ofelia; Jarjanazi, Hamdi; Li, Hong; Sung, Lillian; Ozcelik, Hilmi

    2012-12-01

    The Val762Ala polymorphism poly [ADP-ribose] polymerase 1 (PARP1) gene [ADPRT (adenosine diphosphate ribosyltransferase) gene] affects enzymatic activity, which modulates cancer susceptibility among human populations. Individual data on 13,745 cases and 16,947 controls from 28 published case-control studies were re-evaluated. Odds ratios (OR) were estimated for ethnic group, cancer type, smoking joint effects and studies confined to the Hardy-Weinberg equilibrium. We applied subgroup, sensitivity and outlier analyses as well as the Bonferroni correction for multiple testing. The results show strong evidence that the variant (C) allele confers significant increased risk in the Chinese (OR 1.20-1.44, P < 0.0001-0.002), exacerbated by smoking (OR 1.66-2.53, P < 0.0001) and joint interaction with XRCC1 Arg399Gln (OR 1.39, P < 0.0001) as well as adjustment for tumor type (gastric carcinoma ORs 1.39-2.01, P < 0.0001). These significant effects were unaltered following conservative correction for multiple tests. By contrast, this procedure erased the protective significance in Caucasians, but not in two American subgroups, (i) those in the brain tumor category (0.77-0.79, P < 0.0001) and (ii) smokers in the dominant model (OR 0.86, P < 0.0001). These differential findings between the two ethnicities maybe correlated with significantly (P < 0.0001) greater allele frequency of the variant allele (C) among the Chinese compared to Caucasians. Our racial and tissue-specific summary estimates imply consideration of the Val762Ala polymorphism as candidate gene marker for screening cancer patients' best suited for PARP inhibitor therapy. PMID:23073772

  11. Cell Libraries

    NASA Technical Reports Server (NTRS)

    1994-01-01

    A NASA contract led to the development of faster and more energy efficient semiconductor materials for digital integrated circuits. Gallium arsenide (GaAs) conducts electrons 4-6 times faster than silicon and uses less power at frequencies above 100-150 megahertz. However, the material is expensive, brittle, fragile and has lacked computer automated engineering tools to solve this problem. Systems & Processes Engineering Corporation (SPEC) developed a series of GaAs cell libraries for cell layout, design rule checking, logic synthesis, placement and routing, simulation and chip assembly. The system is marketed by Compare Design Automation.

  12. Alpha linolenic acid (ALA) from Rosa canina, sacha inchi and chia oils may increase ALA accretion and its conversion into n-3 LCPUFA in diverse tissues of the rat.

    PubMed

    Valenzuela B, Rodrigo; Barrera R, Cynthia; González-Astorga, Marcela; Sanhueza C, Julio; Valenzuela B, Alfonso

    2014-07-25

    Alpha-linolenic acid (ALA) is an essential n-3 PUFA; its n-3 LCPUFA derivatives EPA and DHA, which have diverse beneficial effects, are scarce in the human diet. In recent years nontraditional vegetable oils rich in ALA (up to 45%) have been developed as new alternatives to increase ALA consumption. This work evaluated the accretion of ALA, EPA and DHA into the phospholipids extracted from erythrocytes, liver, kidney, small intestine, heart, quadriceps and the brain in rats fed sunflower (SFO), canola (CO), Rosa canina (RCO), sacha inchi (Plukenetia volubilis, SIO) and chia (Salvia hispánica, ChO) oils. Five experimental groups (n = 12 per group) were fed for 21 days with SFO (1% ALA), CO (10% ALA), RCO (33% ALA), SIO (49% ALA), and ChO (64% ALA). SIO and ChO allowed higher ALA accretion in all tissues, except the brain, and a reduction in the content of arachidonic acid in all tissues except the brain. EPA was increased in erythrocytes, liver, kidney, small intestine, heart and quadriceps, but not in the brain. DHA was increased in the liver, small intestine and brain tissues. Our results demonstrate that ALA, when provided in significant amounts, can be converted into n-3 LCPUFA, mostly DHA in the liver and brain. It is suggested that oils rich in ALA, such as SIO and ChO, are good sources for obtaining higher tissue levels of ALA, also allowing its selective conversion into n-3 LCPUFA in some tissues of the rat. PMID:24855655

  13. Dictionaries: British and American. The Language Library.

    ERIC Educational Resources Information Center

    Hulbert, James Root

    An account of the dictionaries, great and small, of the English-speaking world is given in this book. Subjects covered include the origin of English dictionaries, early dictionaries, Noah Webster and his successors to the present, abridged dictionaries, "The Oxford English Dictionary" and later dictionaries patterned after it, the process of…

  14. The enzymology of alanine aminotransferase (AlaAT) isoforms from Hordeum vulgare and other organisms, and the HvAlaAT crystal structure.

    PubMed

    Duff, Stephen M G; Rydel, Timothy J; McClerren, Amanda L; Zhang, Wenlan; Li, Jimmy Y; Sturman, Eric J; Halls, Coralie; Chen, Songyang; Zeng, Jiamin; Peng, Jiexin; Kretzler, Crystal N; Evdokimov, Artem

    2012-12-01

    In this paper we describe the expression, purification, kinetics and biophysical characterization of alanine aminotransferase (AlaAT) from the barley plant (Hordeum vulgare). This dimeric PLP-dependent enzyme is a pivotal element of several key metabolic pathways from nitrogen assimilation to carbon metabolism, and its introduction into transgenic plants results in increased yield. The enzyme exhibits a bi-bi ping-pong reaction mechanism with a K(m) for alanine, 2-oxoglutarate, glutamate and pyruvate of 3.8, 0.3, 0.8 and 0.2 mM, respectively. Barley AlaAT catalyzes the forward (alanine-forming) reaction with a k(cat) of 25.6 s(-1), the reverse (glutamate-forming) reaction with k(cat) of 12.1 s(-1) and an equilibrium constant of ~0.5. The enzyme is also able to utilize aspartate and oxaloacetate with ~10% efficiency as compared to the native substrates, which makes it much more specific than related bacterial/archaeal enzymes (that also have lower K(m) values). We have crystallized barley AlaAT in complex with PLP and l-cycloserine and solved the structure of this complex at 2.7 Å resolution. This is the first example of a plant AlaAT structure, and it reveals a canonical aminotransferase fold similar to structures of the Thermotoga maritima, Pyrococcus furiosus, and human enzymes. This structure bridges our structural understanding of AlaAT mechanism between three kingdoms of life and allows us to shed some light on the specifics of the catalysis performed by these proteins. PMID:22750542

  15. Library Statistics of Schools in the Health Sciences: Part I

    PubMed Central

    1966-01-01

    During the winter of 1965/66, statistics on library staff, clientele, resources, expenditures, salaries, and services of medical, dental, pharmacy, osteopathic, and public health schools were collected by the MLA Committee on Surveys and Statistics. In an attempt to provide standardized information on these libraries, the Committee utilized questionnaires provided by the U.S. Office of Education. The survey was conducted in co-operation with the American Dental Association, the American Association of Dental Schools, the American Council on Pharmaceutical Education, and the American Association of Colleges of Pharmacy. PMID:16017411

  16. Combination therapies in adjuvant with topical ALA-mediated photodynamic therapy for DMBA-induced hamster buccal pouch premalignant lesions

    NASA Astrophysics Data System (ADS)

    Yang, Deng-Fu; Hsu, Yih-Chih

    2012-03-01

    In Taiwan, oral cancer has becomes the fastest growth male cancer disease due to the betel nut chewing habit combing with smoking and alcohol-drinking lifestyle of people. In order to eliminate the systemic phototoxic effect of 5-aminolevulinic acid (ALA), this study was designed to use a topical ALA-mediated PDT for treatment of DMBA-induced hamster buccal pouch precancerous lesions. DMBA was applied to one of the buccal pouches of hamsters thrice a week for 10 to 12 weeks. Cancerous lesions were induced and proven by histological examination. These DMBA-induced cancerous lesions were used for testing the efficacy of topical ALA-mediated PDT. Before PDT, fluorescence spectroscopy was used to determine when ALA reached its peak level in the lesional epithelial cells after topical application of ALA gel. We found that ALA reached its peak level in precancerous lesions about 2.5 hrs after topical application of ALA gel. The cancerous lesions in hamsters were then treated with topical ALA -mediated PDT with light exposure dose of 150 J/cm2 using LED 635 nm fiber-guided light device. Visual examination demonstrated that adjuvant topical ALA -mediated PDT group has shown better therapeutic results in compared to those of non-adjuvant topical ALA-mediated PDT group for DMBA-induced hamster buccal pouch precancerous lesions.

  17. Intensified oxidative and nitrosative stress following combined ALA-based photodynamic therapy and local hyperthermia in rat tumors.

    PubMed

    Frank, Juergen; Lambert, Christine; Biesalski, Hans Konrad; Thews, Oliver; Vaupel, Peter; Kelleher, Debra K

    2003-12-20

    Oxidative stress-related changes in tumors upon localized hyperthermia (HT), 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and their combination (ALA+HT) were examined after the observation that the antitumor effects of ALA-PDT could be significantly enhanced upon simultaneous application of HT. Rats bearing s.c. DS-sarcomas (0.6-1.0 ml) on the hind foot dorsum were anesthetized and underwent one of the following treatments: (i) ALA-PDT (375 mg/kg 5-ALA i.v.); (ii) localized HT, 43 degrees C for 60 min; (iii) combined ALA-PDT and HT [=ALA+HT]. Appropriate control experiments were also performed. After treatment, tumors were excised and rapidly frozen for later analysis of nitrosative stress (protein nitration), apoptotic events (TUNEL, caspase activation, DNA and RNA fragmentation), expression of heat shock proteins (hsp70 and HO-1), glutathione (GSH) levels and glutathione peroxidase (GPx) activity. Protein nitration was found to increase upon treatment, being especially pronounced in the ALA+HT group, and could partially be related to areas surrounding microvessels. The extent of nitrosative stress also correlated well with the appearance of the markers of apoptosis and the inhibition of in vivo tumor growth as seen in a previous study. GSH levels decreased upon treatment, the reduction being most prominent in the ALA-PDT and ALA+HT groups. GPx activity, however, showed a significant decrease only in the ALA-PDT group. Whereas hsp70 expression increased upon HT, ALA-PDT caused a decrease, and these opposing effects were nullified with ALA+HT. The results obtained point to a number of cellular mechanisms-including effects on cellular defense mechanisms and an abrogation of the heat shock defense mechanism-that may interact to achieve the potentiated tumor response rate seen in vivo upon combined treatment. PMID:14601053

  18. Combination of 5-ALA and iMRI in re-resection of recurrent glioblastoma.

    PubMed

    Quick-Weller, Johanna; Lescher, Stephanie; Forster, Marie-Therese; Konczalla, Jürgen; Seifert, Volker; Senft, Christian

    2016-06-01

    Background Tumour resection plays a role in the initial treatment but also in the setting of recurrent glioblastoma (rGBM). To achieve maximum resection, 5-aminolevulinic acid (5-ALA) and intraoperative MRI (iMRI) are used as surgical tools. Aiming at complete tumour re-resection, we started combining iMRI with 5-ALA to find out if this leads to better surgical results. Methods We performed tumour resections in seven patients with rGBM, combining 5-ALA (20 mg/kg bodyweight) with iMRI (0.15 T). Radiologically complete resections were intended in all seven patients. We assessed intraoperative fluorescence findings and compared these with intraoperative imaging. All patients had early postoperative MRI (3 T) to verify final iMRI scans and received adjuvant treatment according to interdisciplinary tumour board decision. Results Median patient age was 63 years. Median KPS score was 90, and median tumour volume was 8.2 cm(3). In six of seven patients (85%), 5-ALA induced fluorescence of tumour-tissue was detected intraoperatively. All tumours were good to visualise with iMRI and contrast media. One patient received additional resection of residual contrast enhancing tissue on intraoperative imaging, which did not show fluorescence. Radiologically complete resections according to early postoperative MRI were achieved in all patients. Median survival since second surgery was 7.6 months and overall survival since diagnosis was 27.8 months. Conclusions 5-ALA and iMRI are important surgical tools to maximise tumour resection also in rGBM. However, not all rGBMs exhibit fluorescence after 5-ALA administration. We propose the combined use of 5-ALA and iMRI in the surgery of rGBM. PMID:26743016

  19. Stimulation of dendritic cells by DAMPs in ALA-PDT treated SCC tumor cells

    PubMed Central

    Zhang, Haiyan; Fan, Zhixia; Zhang, Linglin; Shi, Lei; Zhou, Feifan; Chen, Wei R.; Wang, Hongwei; Wang, Xiuli

    2015-01-01

    Photodynamic therapy (PDT) not only kills tumor cells directly but also rapidly recruits and activates immune cells favoring the development of antitumor adaptive immunity. It is believed that Topical 5-aminolevulinic acid mediated photodynamic therapy (ALA-PDT) can induce anti-tumor immune responses through dangerous signals damage-associated molecular patterns (DAMPs). In this study, we investigated the effect of ALA-PDT induced DAMPs on immune cells. We focused on the stimulation of dendritic cells by major DAMPs, enhanced the expression of calreticulin (CRT), heat shock proteins 70 (HSP70), and high mobility group box 1 (HMGB1), either individually or in combination. We evaluated in vitro and in vivo expressions of DAMPs induced by ALA-PDT using immunohistochemistry, western blot, and ELISA in a squamous cell carcinoma (SCC) mouse model. The role of DAMPs in the maturation of DCs potentiated by ALA-PDT-treated tumor cells was detected by FACS and ELISA. Our results showed that ALA-PDT enhanced the expression of CRT, HSP70, and HMGB1. These induced DAMPs played an important part in activating DCs by PDT-treated tumor cells, including phenotypic maturation (increase of surface expression of MHC-II, CD80, and CD86) and functional maturation (enhanced capability to secrete IFN-γ and IL-12). Furthermore, injecting ALA-PDT-treated tumor cells into naïve mice resulted in complete protection against cancer cells of the same origin. Our findings indicate that ALA-PDT can increase DAMPs and enhance tumor immunogenicity, providing a promising strategy for inducing a systemic anticancer immune response. PMID:26625309

  20. Harnessing cellular differentiation to improve ALA-based photodynamic therapy in an artificial skin model

    NASA Astrophysics Data System (ADS)

    Maytin, Edward; Anand, Sanjay; Sato, Nobuyuki; Mack, Judith; Ortel, Bernhard

    2005-04-01

    During ALA-based photodynamic therapy (PDT), a pro-drug (aminolevulinic acid; ALA) is taken up by tumor cells and metabolically converted to a photosensitizing intermediate (protoporphyrin IX; PpIX). ALA-based PDT, while an emerging treatment modality, remains suboptimal for most cancers (e.g. squamous cell carcinoma of the skin). Many treatment failures may be largely due to insufficient conversion of ALA to PpIX within cells. We discovered a novel way to increase the conversion of ALA to PpIX, by administering agents that can drive terminal differentiation (i.e., accelerate cellular maturation). Terminally-differentiated epithelial cells show higher levels of intracellular PpIX, apparently via increased levels of a rate-limiting enzyme, coproporphyrinogen oxidase (CPO). To study these mechanisms in a three-dimensional tissue, we developed an organotypic model that mimics true epidermal physiology in a majority of respects. A line of rat epidermal keratinocytes (REKs), when grown in raft cultures, displays all the features of a fully-differentiated epidermis. Addition of ALA to the culture medium results in ALA uptake and PpIX synthesis, with subsequent death of keratinocytes upon exposure to blue light. Using this model, we can manipulate cellular differentiation via three different approaches. (1) Vitamin D, a hormone that enhances keratinocyte differentiation; (2) Hoxb13, a nuclear transcription factor that affects the genetically-controlled differentiation program of stratifying cells (3) Hyaluronan, an abundant extracellular matrix molecule that regulates epidermal differentiation. Because the raft cultures contain only a single cell type (no blood, fibroblasts, etc.) the effects of terminal differentiation upon CPO, PpIX, and keratinocyte cell death can be specifically defined.

  1. Library Services. Miscellaneous Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Papers on library journal cooperation, interlibrary lending, library services to minorities, and school library media centers, which were presented at the 1983 International Federation of Library Associations (IFLA) conference, include: (1) "The Co-operation between Editors of Library Journals in Socialist Countries," in which Wolfgang Korluss…

  2. Library Handbook for Faculty.

    ERIC Educational Resources Information Center

    Martinez, Angelina, Ed.

    Discussions of library resources, services and related activities as well as library materials selection and acquisition are provided for faculty to facilitate and enhance their use of the library. Included in the library resources section are books, periodicals, microforms, and special collections and archives. Instruction in library use,…

  3. Library Directions in 1988.

    ERIC Educational Resources Information Center

    DeCandido, GraceAnne A.

    1989-01-01

    Reviews major library issues and events of 1988, including: (1) the Federal Bureau of Investigation's Library Awareness Program; (2) cooperation with USSR libraries; (3) library finance; (4) preservation; and (5) special programing. News about a number of prominent library professionals is included in a sidebar. (MES)

  4. Public Library in Thailand.

    ERIC Educational Resources Information Center

    Lerdsuriyakul, Kulthorn

    This paper on public libraries in Thailand begins with a section that provides background on public libraries in the past, lists the functions of the public library, and describes three size classifications of public libraries. The second section outlines the tasks of the current public library in three areas: informal education; nonformal…

  5. 24. Photocopy of 1906 photograph. Original in library of Lehmann ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Photocopy of 1906 photograph. Original in library of Lehmann Building, Missouri Botanical Garden. VIEW FROM THE SOUTH OVER 'TUPEES POND' OF THE OLMSTED'S NORTH AMERICAN TRACT - Missouri Botanical Garden, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

  6. Crystallization of tholeiitic basalt in Alae Lava Lake, Hawaii

    USGS Publications Warehouse

    Peck, D.L.; Wright, T.L.; Moore, J.G.

    1966-01-01

    The eruption of Kilauea Volcano August 21-23, 1963, left 600,000 cubic meters of basaltic lava in a lava lake as much as 15 meters deep in Alae pit crater. Field studies of the lake began August 27 and include repeated core drilling, measurements of temperature in the crust and melt, and precise level surveys of the lake surface. The last interstitial melt in the lake solidified late in September 1964; by mid August 1965 the maximum temperature was 690??C at a depth of 11.5 meters. Pumice air-quenched from about 1140??C contains only 5 percent crystals - clinopyroxene, cuhedral olivine (Fo 80), and a trace of plagioclase, (An 70). Drill cores taken from the zone of crystallization in the lake show that olivine continued crystallizing to about 1070??C; below that it reacts with the melt, becoming corroded and mantled by pyroxene and plagioclase. Below 1070??C, pyroxene and plagioclase crystallized at a constant ratio. Ilmenite first appeared at about 1070??C and was joined by magnetite at about 1050??C; both increased rapidly in abundance to 1000??C. Apatite first appeared as minute needles in interstitial glass at 1000??C. Both the abundance and index of refraction of glass quenched from melt decreased nearly linearly with falling temperature. At 1070??C the quenched lava contains about 65 percent dark-brown glass with an index of 1.61; at 980??C it contains about 8 percent colorless glass with an index of 1.49. Below 980??C, the percentage of glass remained constant. Progressive crystallization forced exsolution of gases from the melt fraction; these formed vesicles and angular pores, causing expansion of the crystallizing lava and lifting the surface of the central part of the lake an average of 19.5 cm. The solidified basalt underwent pneumatolitic alteration, including deposition of cristobalite at 800??C, reddish alteration of olivine at 700??C, tarnishing of ilmenite at 550??C, deposition of anhydrite at 250??C, and deposition of native sulfur at 100??C

  7. Harmony in Diversity: Recommendations for Effective Library Service to Asian Language Speakers.

    ERIC Educational Resources Information Center

    Wong, Patty, Comp.

    This document, to provide for effective library service to Asian language speakers, includes information on the culture of Chinese Americans, Filipino Americans, Japanese Americans, and Vietnamese Americans. For each group, the following are described: generations, immigration and length of United States residency; family and children; language;…

  8. Designs for Change: Libraries and Productive Aging. Report on the National Library Leaders Forum (Washington, DC, September 26-27, 2005)

    ERIC Educational Resources Information Center

    Zeisel, William

    2006-01-01

    As the first of the baby boomers turn 60, public libraries are preparing to offer creative alternatives to retirement to a generation notorious for their idealism and activism. This report from the Americans for Libraries Council (ALC) and the Institute of Museum and Library Services (IMLS) offers guidelines, demographics, and examples of model…

  9. The dipeptide alanylphenylalanine ( H-Ala-Phe-OH) - protonation and coordination ability with Au(III)

    NASA Astrophysics Data System (ADS)

    Koleva, B. B.; Kolev, Ts.; Zareva, S. Y.; Spiteller, M.

    2007-04-01

    The dipeptide alanylphenylalanine ( H-Ala-Phe-OH), its hydrochloride ( HCl × H-Ala-Phe-OH) and Au(III)-complex have been characterized structurally. Quantum chemical DFT and ab initio calculations, solid-state linear-dichroic infrared (IR-LD) spectroscopy and 1H and 13C NMR data were employed. The results are confirmed by a single crystal X-ray diffraction analysis of HCl × H-Ala-Phe-OH. The coordination with Au(III) is supported by data from MS, TGV, DSC methods and by elemental analysis. The H-Ala-Phe-OH coordinates in a bidentate manner via an O-atom of the COO --group and N-amide nitrogen, after a previous deprotonation of the NH-group has taken place. Two Cl - ions are attached to the metal center as terminal ligands, yielding a completely planar geometry for the AuNOCl 2 chromophor in the mononuclear [Au(( H-Ala-Phe-OH)H -1)Cl 2] complex.

  10. Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions.

    PubMed

    Minamikawa, Takeo; Matsuo, Hisataka; Kato, Yoshiyuki; Harada, Yoshinori; Otsuji, Eigo; Yanagisawa, Akio; Tanaka, Hideo; Takamatsu, Tetsuro

    2016-01-01

    5-aminolevulinic acid (5-ALA)-based fluorescence diagnosis is now clinically applied for accurate and ultrarapid diagnosis of malignant lesions such as lymph node metastasis during surgery. 5-ALA-based diagnosis evaluates fluorescence intensity of a fluorescent metabolite of 5-ALA, protoporphyrin IX (PPIX); however, the fluorescence of PPIX is often affected by autofluorescence of tissue chromophores, such as collagen and flavins. In this study, we demonstrated PPIX fluorescence estimation with autofluorescence elimination for 5-ALA-based fluorescence diagnosis of malignant lesions by simplified and optimized multispectral imaging. We computationally optimized observation wavelength regions for the estimation of PPIX fluorescence in terms of minimizing prediction error of PPIX fluorescence intensity in the presence of typical chromophores, collagen and flavins. By using the fluorescence intensities of the optimized wavelength regions, we verified quantitative detection of PPIX fluorescence by using chemical mixtures of PPIX, flavins, and collagen. Furthermore, we demonstrated detection capability by using metastatic and non-metastatic lymph nodes of colorectal cancer patients. These results suggest the potential and usefulness of the background-free estimation method of PPIX fluorescence for 5-ALA-based fluorescence diagnosis of malignant lesions, and we expect this method to be beneficial for intraoperative and rapid cancer diagnosis. PMID:27149301

  11. Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions

    PubMed Central

    Minamikawa, Takeo; Matsuo, Hisataka; Kato, Yoshiyuki; Harada, Yoshinori; Otsuji, Eigo; Yanagisawa, Akio; Tanaka, Hideo; Takamatsu, Tetsuro

    2016-01-01

    5-aminolevulinic acid (5-ALA)-based fluorescence diagnosis is now clinically applied for accurate and ultrarapid diagnosis of malignant lesions such as lymph node metastasis during surgery. 5-ALA-based diagnosis evaluates fluorescence intensity of a fluorescent metabolite of 5-ALA, protoporphyrin IX (PPIX); however, the fluorescence of PPIX is often affected by autofluorescence of tissue chromophores, such as collagen and flavins. In this study, we demonstrated PPIX fluorescence estimation with autofluorescence elimination for 5-ALA-based fluorescence diagnosis of malignant lesions by simplified and optimized multispectral imaging. We computationally optimized observation wavelength regions for the estimation of PPIX fluorescence in terms of minimizing prediction error of PPIX fluorescence intensity in the presence of typical chromophores, collagen and flavins. By using the fluorescence intensities of the optimized wavelength regions, we verified quantitative detection of PPIX fluorescence by using chemical mixtures of PPIX, flavins, and collagen. Furthermore, we demonstrated detection capability by using metastatic and non-metastatic lymph nodes of colorectal cancer patients. These results suggest the potential and usefulness of the background-free estimation method of PPIX fluorescence for 5-ALA-based fluorescence diagnosis of malignant lesions, and we expect this method to be beneficial for intraoperative and rapid cancer diagnosis. PMID:27149301

  12. Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women.

    PubMed

    Jin, Fuxia; Nieman, David C; Sha, Wei; Xie, Guoxiang; Qiu, Yunping; Jia, Wei

    2012-06-01

    Ten postmenopausal women (age 55.6 ± 0.8 years, BMI 24.6 ± 1.1 kg/m²) ingested 25 g/day milled chia seed during a 7-week period, with six plasma samples collected for measurement of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Subjects operated as their own controls with overnight fasted blood samples taken at baseline (average of two samples), and then after 1, 2, 3, 5, and 7 weeks supplementation. Plasma ALA increased significantly after one week supplementation and was 138 % above baseline levels by the end of the study (overall time effect, P < 0.001). EPA increased 30 % above baseline (overall time effect, P = 0.019) and was correlated across time with ALA (r = 0.84, P = 0.02). No significant change in plasma DPA levels was measured (overall time effect, P = 0.067). Plasma DHA decreased slightly by the end of the study (overall time effect, P = 0.030) and was not correlated with change in ALA. In conclusion, ingestion of 25 g/day milled chia seeds for seven weeks by postmenopausal women resulted in significant increases in plasma ALA and EPA but not DPA and DHA. PMID:22538527

  13. Flourescence analysis of ALA-induced Protoporphyrin IX in psoriatic plaque

    NASA Astrophysics Data System (ADS)

    Stringer, Mark R.; Robinson, Dominic J.; Collins, P.

    1996-01-01

    The success reported for the treatment of superficial skin carcinomas by photodynamic therapy (PDT), following topical application of 5-aminolaevulinic acid (ALA), has therapeutic implications for the treatment of other skin disorders. This presentation describes the accumulation of the photosensitizing agent protoporphyrin IX (PpIX) in areas of psoriatic plaque, by monitoring the fluorescence emission induced by low-intensity laser excitation at 488 nm. We present the results from 15 patients, with a total of 42 plaques. These results show that PpIX fluorescence increases in intensity within the 6 hour period following application of ALA, which implies there is a potential for PDT. The emission is localized to the area of ALA application and the effect of occlusion appears insignificant. Also, the rate of increase, and maximum intensity of fluorescence emission, is not directly related to the applied quantity of ALA. The variability of the fluorescence intensity is as great between plaques at different sites on the same patient as between different patients. We also present measurements of the depletion in intensity of fluorescence emission during PDT treatment, using white light, at an irradiance of 25 mW cm-2, that is a consequence of the molecular photo-oxidation of PpIX. The use of fluorescence measurements in predicting the therapeutic effect of treating plaque psoriasis by ALA-PDT is discussed.

  14. Protective Effect of ALA in Crushed Optic Nerve Cat Retinal Ganglion Cells Using a New Marker RBPMS

    PubMed Central

    Wang, Yanling; Wang, Wenyao; Liu, Jessica; Huang, Xin; Liu, Ruixing; Xia, Huika; Brecha, Nicholas C.; Pu, Mingliang; Gao, Jie

    2016-01-01

    In this study we first sought to determine whether RNA-binding protein with multiple splicing (RBPMS) can serve as a specific marker for cat retina ganglion cells (RGCs) using retrograde labeling and immunohistochemistry staining. RBPM was then used as an RGC marker to study RGC survival after optic nerve crush (ONC) and alpha-lipoic acid (ALA) treatment in cats. ALA treatment yielded a peak density of RBPMS-alpha cells within the peak isodensity zone (>60/mm2) which did not differ from ONC retinas. The area within the zone was significantly enlarged (control: 2.3%, ONC: 0.06%, ONC+ALA: 0.1%). As for the 10-21/mm2 zone, ALA treatment resulted in a significant increase in area (control: 34.5%, ONC: 12.1%, ONC+ALA: 35.9%). ALA can alleviate crush-induced RGC injury. PMID:27504635

  15. The American Experience: Strength from Diversity.

    ERIC Educational Resources Information Center

    Gebel, Doris, Comp.; Bange, Stephanie, Comp.; Cooper, Susan A., Comp.; Finkbeiner, Andrew, Comp.; James, Helen Foster, Comp.; Kuharets, Olga, Comp.; Lamb, Jeanne, Comp.; Ng, Janet, Comp.; Nguyen, Holly, Comp.; Phelan, Carolyn, Comp.; Strong, Sunny, Comp.; Sutherland, Zena, Comp.; Voors, Mary, Comp.

    2002-01-01

    Presents an annotated bibliography of 28 children's picture books that celebrate diverse cultures in American society, developed by the International Relations Committee of the Association of Library Services to Children. (LRW)

  16. Light Fractionation Significantly Increases the Efficacy of Photodynamic Therapy Using BF-200 ALA in Normal Mouse Skin

    PubMed Central

    de Bruijn, Henriëtte S.; Brooks, Sander; van der Ploeg-van den Heuvel, Angélique; ten Hagen, Timo L. M.; de Haas, Ellen R. M.; Robinson, Dominic J.

    2016-01-01

    Background Light fractionation significantly increases the efficacy of 5-aminolevulinic acid (ALA) based photodynamic therapy (PDT) using the nano-emulsion based gel formulation BF-200. PDT using BF-200 ALA has recently been clinically approved and is under investigation in several phase III trials for the treatment of actinic keratosis. This study is the first to compare BF-200 ALA with ALA in preclinical models. Results In hairless mouse skin there is no difference in the temporal and spatial distribution of protoporphyrin IX determined by superficial imaging and fluorescence microscopy in frozen sections. In the skin-fold chamber model, BF-200 ALA leads to more PpIX fluorescence at depth in the skin compared to ALA suggesting an enhanced penetration of BF-200 ALA. Light fractionated PDT after BF-200 ALA application results in significantly more visual skin damage following PDT compared to a single illumination. Both ALA formulations show the same visual skin damage, rate of photobleaching and change in vascular volume immediately after PDT. Fluorescence immunohistochemical imaging shows loss of VE-cadherin in the vasculature at day 1 post PDT which is greater after BF-200 ALA compared to ALA and more profound after light fractionation compared to a single illumination. Discussion The present study illustrates the clinical potential of light fractionated PDT using BF-200 ALA for enhancing PDT efficacy in (pre-) malignant skin conditions such as basal cell carcinoma and vulval intraepithelial neoplasia and its application in other lesion such as cervical intraepithelial neoplasia and oral squamous cell carcinoma where current approaches have limited efficacy. PMID:26872051

  17. Comparison of American medical dictionaries.

    PubMed Central

    Callard, J C; Fruehauf, E L

    1978-01-01

    Although American medical dictionaries are a valuable part of any medical library collection, the attributes of each of the four major dictionaries are often unknown and the reference material contained in each unused. The medical librarian should be aware of the differences and values of each dictionary and try to have at least one edition of each available to library users in order to maintain an adequate reference collection. PMID:354707

  18. Communication Standards for Online Interchange of Library Information.

    ERIC Educational Resources Information Center

    Brown, Thomas P.

    1982-01-01

    Presents new perspective on computerized information interchange within library community, and explains Open Systems Interconnection Model promoted by International Organization for Standardization, American National Standards Institute, and National Bureau of Standards. The Linked System Project undertaken by Library of Congress, Research…

  19. A Utilitarian Case for Intellectual Freedom in Libraries.

    ERIC Educational Resources Information Center

    Doyle, Tony

    2001-01-01

    Outlines the history of censorship and intellectual and expressive freedom in American libraries; discusses the two main types of ethical theory, utilitarianism and deontology; and maintains that libraries have a special role to play in promoting unconditional intellectual freedom. (Author/LRW)

  20. A Janus-Faced View of Libraries in the Future.

    ERIC Educational Resources Information Center

    Trask, Benjamin H.

    1995-01-01

    By examining 87 futuristic articles published between 1919 and 1961 in American library or related journals, and 6 professional monographs within the same time span, the accuracy of forecasting library futures is assessed. The effects of war, the economy, and technology on librarians' ideas of the future are discussed, and trends in predictions…

  1. Library Schools in North America and Elsewhere: Cooperative Agreements.

    ERIC Educational Resources Information Center

    Marco, Guy

    1980-01-01

    Reviews the institutional agreements between graduate library schools in the U.S. and Canada and those in other countries which were identified by surveys of members of the Association of American Library Schools, and the formation of the Program of International Partnerships (PIP) to encourage such activities. (RAA)

  2. Marketing and Public Relations in ARL Libraries. SPEC Kit 240.

    ERIC Educational Resources Information Center

    Smykla, Evelyn Ortiz, Comp.

    1999-01-01

    This survey was conducted to delineate the growing relationship between marketing and public relations and library funding by identifying: (1) the extent to which North American research libraries have developed organized programs in the areas of marketing and public relations; (2) who holds positions in these areas; and (3) the impact these…

  3. A Model Privacy Statement for Ohio Library Web Sites.

    ERIC Educational Resources Information Center

    Monaco, Michael J.

    The purpose of this research was to develop a model privacy policy statement for library World Wide Web sites. First, standards of privacy protection were identified. These standards were culled from the privacy and confidentiality policies of the American Library Association, the Federal Trade Commission's online privacy reports, the guidelines…

  4. Public Libraries in Metropolitan Miami: Aqui Se Habla Espanol?

    ERIC Educational Resources Information Center

    Foster, Barbara

    1989-01-01

    Describes library services of the Miami-Dade library system for the Hispanic community. The system provides a variety of bibliographic and community outreach services for Hispanic American users, who constitute about 40 percent of the population. Services to this community may be threatened by English Only legislation pending in South Florida. (AF)

  5. Campus Partner Collections: Expanding the Boundaries of the Library

    ERIC Educational Resources Information Center

    Elguindi, Anne C.; Kelshian, Robert; Sandler, Alayne Mundt

    2011-01-01

    At most colleges and universities, there are a number of small, nonlibrary collections across campus, such as those found in student centers or academic departments. Historically, at American University, partnership with these collections was done through absorbing them into the main library collection. Recently, however, the Library has seen…

  6. United States: Reaching out with Library Services for GLBTQ Teens

    ERIC Educational Resources Information Center

    Carter, Julie

    2005-01-01

    Although major strides toward the inclusion of GLBT images in North American libraries have indeed been achieved, censorship is alive and well where children's literature is concerned. It is plain to see that libraries have become a major battleground for the free flow of information about and for GLBTQ children and families. This article…

  7. Assistive Technologies for Library Patrons with Visual Disabilities

    ERIC Educational Resources Information Center

    Sunrich, Matthew; Green, Ravonne

    2007-01-01

    This study provides an overview of the various products available for library patrons with blindness or visual impairments. To provide some insight into the status of library services for patrons with blindness, a sample of American universities that are recognized for their programs for students with visual impairments was surveyed to discern…

  8. FLC/FEDLINK AACR 2 Cataloging Manual for Federal Libraries.

    ERIC Educational Resources Information Center

    Wajenberg, Arnold S.

    Intended as a guide for federal agency libraries in the application of the second edition of the Anglo-American Cataloging Rules and not to supersede them, the emphasis in this manual is on material and problems likely to be encountered by catalogers in the area of descriptive cataloging, and it includes the most recent Library of Congress rule…

  9. Where Have All the Ultras Gone? The Rise and Demise of the Ultrafiche Library Collection, 1968-1973.

    ERIC Educational Resources Information Center

    Yerburgh, Mark R.; Yerburgh, Rhoda

    1984-01-01

    Identifies factors undermining library phenomenon of "ultrafiche" collection. Proposal of concept by Rand Corporation (1968), publication of two prototype collections (Library Resources Inc.'s "Library of American Civilization," and National Cash Register's "PCMI Library Collections"), and forces having adverse effect on viability and longevity of…

  10. The Library of Virginia's Digital Library Project.

    ERIC Educational Resources Information Center

    Roderick, Elizabeth; Taylor, Jean Marie; Byrd, Sam; Courson, Glenn

    1997-01-01

    Describes The Library of Virginia's Digital Library Project that has made many of its state library collections available via the Internet and World Wide Web. Highlights include digitization decisions; the HTML Web gateway; the online catalog; microfilm digitization; users and use statistics; and future projects. (LRW)

  11. Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): current clinical and development status

    NASA Astrophysics Data System (ADS)

    Marcus, Stuart L.; Sobel, Russel S.; Golub, Allyn L.; Carroll, Ronald L.; Lundahl, Scott L.; Shulman, D. Geoffrey

    1996-04-01

    Exogenous provision of ALA to many tissues results in the accumulation of sufficient quantities of the endogenous photosensitizer protoporphyrin IX, (PpIX), to produce a photodynamic effect. Therefore, ALA may be considered the only current PDT agent in clinical development which is a biochemical precursor of a photosensitizer. Topical ALA application, followed by exposure to activating light (ALA PDT), has been reported effective for the treatment of a variety of dermatologic diseases including cutaneous T-cell lymphoma, superficial basal cell carcinoma, Bowen's disease, and actinic (solar) keratoses, and is also being examined for treatment of acne and hirsutism. PpIX induced by ALA application also may serve as a fluorescence detection marker for photodiagnosis (PD) of malignant and pre- malignant conditions of the urinary bladder and other organs. Local internal application of ALA has also been used for selective endometrial ablation in animal model systems and is beginning to be examined in human clinical studies. Systemic, oral administration of ALA has been used for ALA PDT of superficial head and neck cancer, various gastrointestinal cancers, and the condition known as Barrett's esophagus. This brief paper reviews the current clinical and development status of ALA PDT.

  12. Assessment of ALA-induced PpIX production in porcine skin pretreated with microneedles.

    PubMed

    Rodrigues, Phamilla Gracielli Sousa; Campos de Menezes, Priscila Fernanda; Fujita, Alessandra Keiko Lima; Escobar, André; Barboza de Nardi, Andrigo; Kurachi, Cristina; Bagnato, Vanderlei S

    2015-09-01

    Photodynamic therapy (PDT) is used for skin treatments of premalignant and cancer lesions and recognized as a non-invasive technique that combines tissue photosensitization and subsequent exposure to light to induce cell death. However, it is limited to the treatment of superficial lesions, mainly due to the low cream penetration. Therefore, the improvement of transdermal distribution of aminolevulinic acid (ALA) is needed. In this study, the kinetics and homogeneity of production of ALA-induced PpIX after the skin pre-treatment with microneedles rollers of 0.5, 1.0 and 1.5 mm length were investigated. An improvement in homogeneity and production of PpIX was shown in a porcine model. Widefield fluorescence imaging three hours after the topical application of ALA-cream in the combined treatment with microeedles rollers. PMID:25319567

  13. Alabama Public Library Service Library Directory and 1996 Statistical Report.

    ERIC Educational Resources Information Center

    Alabama Public Library Service, Montgomery.

    This publication presents library contact information and statistics for Alabama public libraries for fiscal year 1996 (October 1, 1995-September 30, 1996). The library directory is arranged by type of library: public libraries, single-county public library systems, multi-county public library systems, and multitype library systems. Entries…

  14. Help! Libraries and the Hard of Hearing.

    ERIC Educational Resources Information Center

    1982

    This transcript contains the text of three speeches on the problems of people with hearing impairments and the provision of library services to the hard of hearing. Howard Edward (Rocky) Stone, founder of Self-Help-For-Hearing-Impaired-People, Inc., describes his difficulties as a hearing impaired person, the growing number of Americans with…

  15. Marketing Your Library with the Big Read

    ERIC Educational Resources Information Center

    Johnson, Wendell G.

    2012-01-01

    The Big Read was developed by the National Endowment for the Arts to revitalize the role of culture in American society and encourage the reading of landmark literature. Each year since 2007, the DeKalb Public Library, Northern Illinois University, and Kishwaukee Community College have partnered to foster literacy in the community. This article…

  16. Libraries and the Right to Read.

    ERIC Educational Resources Information Center

    Molz, Kathleen, Comp.

    In common with many other people, librarians have been too prompt to assume that availability of books and materials will necessarily lead to their utilization. What has happened in all too many American communities is that libraries are intensively used by only a small portion of the population, while the vast majority are untouched by the…

  17. Telecommunication Technologies for Libraries: A Basic Guide.

    ERIC Educational Resources Information Center

    Matthews, Joseph R.; Williams, Joan Frye

    1983-01-01

    This introduction to modern telecommunications technology explains key technical concepts and relates them to library functions, identifies available services, and projects development trends in intelligent network services and alternative telecommunication technologies. A glossary and 10-item bibliography are included. (American Library…

  18. Some Observations on Metadata and Digital Libraries.

    ERIC Educational Resources Information Center

    Arms, Caroline R.

    This paper describes experiences in gathering together metadata from heterogeneous sources for the American Memory project of the Library of Congress, particularly for the collections digitized and cataloged at other institutions. It also reflects on several initiatives to develop rich structured metadata schemes for specific domains and to find…

  19. Library Censorship and the Permissive Minority.

    ERIC Educational Resources Information Center

    White, Howard D.

    1981-01-01

    A nationwide survey of 2,486 American adults, conducted for the Commission on Obscenity and Pornography in 1970, is reanalyzed to permit new comparisons of the large majority who favored library censorship of erotica with the minority who opposed it. Sixteen references are cited. (Author/FM)

  20. Mapping Academic Library Contributions to Campus Internationalization

    ERIC Educational Resources Information Center

    Witt, Steven W.; Kutner, Laurie; Cooper, Liz

    2015-01-01

    This study surveyed academic libraries across the United States to establish baseline data on their contributions to campus internationalization. Supplementing data from the American Council on Education (ACE) on internationalization of higher education, this research measured the level of international activities taking place in academic…

  1. Great Explorations: Discovering Science in the Library.

    ERIC Educational Resources Information Center

    Sosa, Maria, Ed.; And Others

    The American Association for the Advancement of Science (AAAS) Library Institute was a project that brought together 28 school and public librarians from the Washington, D.C., metropolitan area to discuss science, mathematics, and technology. education reform and what can be done to bring it about. This book discusses the project in 12 chapters:…

  2. Tribal Library Procedures Manual. TRAILS (Training and Assistance for Indian Library Services), September 10, 1985-January 10, 1987.

    ERIC Educational Resources Information Center

    Patterson, Lotsee

    This manual resulted from a 2-year project to improve, develop, and expand public library and information services to American Indians and Alaska Natives. Designed to serve as a guide for tribal and community librarians who may lack professional training, the manual offers descriptions of library services, procedures, and management issues. An…

  3. Funding Programs and Grant-Making Agencies: National Endowment for the Humanities; Institute of Museum and Library Services Library Programs.

    ERIC Educational Resources Information Center

    Phelps, Thomas C.; Martin, Robert S.

    2003-01-01

    Includes reports from the National Endowment for the Humanities, discussing grants, federal-state partnerships, and a directory of state humanities councils; and from the Institute of Museum and Library Services Library Programs, including state-administered programs, funding, national leadership grant awards, Native American grants, and national…

  4. Descriptive cataloging of serials: the National Library of Medicine versus the Library of Congress.

    PubMed

    Martinelli, J A

    1980-01-01

    Descriptive cataloging practices for serial differ significantly in some respects between the Library of Congress and the National Library of Medicine. This paper compares some of these differences and indicates the impact they can have on the development of on-line cooperative data bases such as OCLC. Attention is also given to the possible impact of the second edition of the Anglo-American Cataloguing Rules on serials cataloging. The need for standardization is stressed. PMID:7356496

  5. ALA PDT for high grade dysplasia in Barrett's oesophagus: review of a decade's experience

    NASA Astrophysics Data System (ADS)

    Bown, Stephen G.; Mackenzie, Gary D.; Dunn, Jason M.; Thorpe, Sally M.; Lovat, Laurence B.

    2009-06-01

    We have been investigating PDT with 5 aminolaevulinic acid (ALA) for the treatment of high grade dysplasia (HGD) in Barrett's oesophagus (BO) for over a decade. This drug has inherent advantages over porfimer sodium (Photofrin), the current approved photosensitiser in the UK and USA, which causes strictures in 18-50% and light sensitivity for up to three months. ALA has a lower rate of oesophageal strictures due to its preferential activity in the mucosa, sparing the underlying muscle, and patients are only light sensitive for 1-2 days. Within a randomised controlled trial, we demonstrated that an ALA dose of 60mg/kg activated by 1000J/cm red laser light is the most effective. Using these values we achieved complete reversal of HGD at 1 year in 89% of 27 patients. A randomised controlled trial of ALA vs porfimer sodium PDT for HGD is currently under way with end points of efficacy and safety. 50 of 66 patients have been recruited. Preliminary data suggest ALA PDT is safer with a trend to higher efficacy. Late relapse can occur in 20% of patients. New prognostic markers, in particular aneuploidy, are helping us to identify and target patients at risk of late relapse. Furthermore optical biopsy techniques such as elastic scattering spectroscopy (ESS) may allow detection of nuclear abnormalities in vivo and enable us to target areas of interest whilst reducing sampling error. PDT faces new challenges for the treatment of HGD in BO, with the recent introduction of balloon based radiofrequency ablation. This technique appears simpler and as effective as PDT, but follow up is currently short and long term safety data is lacking. In our experience ALA PDT is currently the most effective minimally invasive treatment for HGD in BO. This work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme.

  6. Distribution of ALA metabolic products in esophageal carcinoma cells using spectrally resolved confocal laser microscopy

    NASA Astrophysics Data System (ADS)

    Smolka, Jozef; Mateasik, Anton

    2006-08-01

    Aminolevulinic acid (ALA) is an efficient substance used in photodynamic therapy (PDT). It is a precursor of light-sensitive products that can selectively accumulate in malignant cells following the altered activity of the heme biosynthetic pathway enzymes in such cells. These products are synthesized in mitochondria and distributed to various cellular structures [1]. The localization of ALA products in subcellular structures depends on their chemical characteristics as well as on the properties of the intracellular environment [2]. Characterization of such properties is possible by means of fluorescent probes like JC-1 and carboxy SNARF-1. However, the emission spectra of these probes are overlapped with spectral pattern of typical ALA product -protoporphyrin IX (PpIX). Spectral overlap of fluorescence signals prevents to clearly separate a distribution of probes from PpIX distribution what can completely mess the applicability of these probes in characterization of cell properties. The spectrally resolved confocal laser microscopy can be used to overcome this problem. In this study, a distribution of ALA metabolic products in relation to the mitochondrial membrane potential and intracellular pH was examined. Human cell lines (KYSE-450, KYSE-70) from esophageal squamous cell carcinoma were used. Cells were incubated with 1mM solution of ALA for four hours. Two fluorescent probes, carboxy SNARF-1 and JC-1 , were used to monitor intracellular pH levels and to determine membrane potential changes, respectively. The samples were scanned by spectrally resolved laser scanning microscope. Spectral linear unmixing method was used to discriminate and separate regions of accumulation of ALA metabolic products of JC-1 and carboxy SNARF-1.

  7. Photodynamic damage study of HeLa cell line using ALA

    NASA Astrophysics Data System (ADS)

    AlSalhi, M. S.; Atif, M.; AlObiadi, A. A.; Aldwayyan, A. S.

    2011-04-01

    The present study evaluates the photodynamic damage with 5-aminolevulinic acid (5-ALA) using HeLa as experimental model. HeLa cell line was irradiated with red light (He-Ne laser, λ = 632.8 CW nm). The influence of different incubation times and concentrations of 5-ALA, different irradiation doses and various combinations of photosensitizer and light doses on the cellular viability of HeLa cells were studied. The optimal uptake of photosensitizer ALA in HeLa cells was investigated by means of PpIX fluorescence intensity by exciting the HeLa cell suspension at 450 nm and a detection wavelength set at 690 nm. Cells viability was determined by means of trypan blue solution. The spectrometric measurements showed that the maximal cellular uptake of 5-ALA occurred after 4 h in vitro incubation. We found that the combination with 5-ALA and laser irradiation leads to time/concentration-dependent increase of cells death and also energy doses-dependent enlarge the cells death. The fluorescence intensity after PDD of carcinoma cells reduce when compared with the control group. The fluorescence emission spectral profiles after PDD of carcinoma cells showed a dip around 425-525 nm when compared with the control group. This may be due to the damage of mitochondria component of cells. The percentage of HeLa cells after PDD shows that the percentage of cells survival rate as function of laser dose (power). Hence it is clear that at 200 μg/ml ALA and 20 mW laser irradiation, more than 70% of HeLa cells were dead after 15 min.

  8. Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.

    PubMed Central

    Ortel, B.; Chen, N.; Brissette, J.; Dotto, G. P.; Maytin, E.; Hasan, T.

    1998-01-01

    A treatment regimen that takes advantage of the induction of intracellular porphyrins such as protoporphyrin IX (PPIX) by exposure to exogenous 5-amino-laevulinic acid (ALA) followed by localized exposure to visible light represents a promising new approach to photodynamic therapy (PDT). Acting upon the suggestion that the effectiveness of ALA-dependent PDT may depend upon the state of cellular differentiation, we investigated the effect of terminal differentiation upon ALA-induced synthesis of and the subsequent phototoxicity attributable to PPIX in primary mouse keratinocytes. Induction of keratinocyte differentiation augmented intracellular PPIX accumulation in cells treated with ALA. These elevated PPIX levels resulted in an enhanced lethal photodynamic sensitization of differentiated cells. The differentiation-dependent increase in cellular PPIX levels resulted from several factors including: (a) increased ALA uptake, (b) enhanced PPIX production and (c) decreased PPIX export into the culture media. Simultaneously, steady-state levels of coproporphyrinogen oxidase mRNA increased but aminolaevulinic acid dehydratase mRNA levels remained unchanged. From experiments using 12-o-tetradecanoylphorbol-13-acetate, transforming growth factor beta 1 and calcimycin we demonstrated that the increase in PPIX concentration in terminally differentiating keratinocytes is calcium- and differentiation specific. Stimulation of the haem synthetic capacity is seen in primary keratinocytes, but not in PAM 212 cells that fail to undergo differentiation. Interestingly, increased PPIX formation and elevated coproporphyrinogen oxidase mRNA levels are not limited to differentiating keratinocytes; these were also elevated in the C2C12 myoblast and the PC12 adrenal cell lines upon induction of differentiation. Overall, the therapeutic implications of these results are that the effectiveness of ALA-dependent PDT depends on the differentiation status of the cell and that this may enable

  9. Increase of the electron mobility in HEMT heterostructures with composite spacers containing AlAs nanolayers

    SciTech Connect

    Vinichenko, A. N. Gladkov, V. P.; Kargin, N. I.; Strikhanov, M. N.; Vasil’evskii, I. S.

    2014-12-15

    The effect of the hybridization of quantum states on electron transport in a two-barrier quantum well δ-doped through a spacer layer at the limit of heavy doping is shown theoretically and experimentally. A method for increasing the electron mobility in the quantum well by suppressing the tunnel coupling with the donor region through the introduction of an AlAs nanobarrier into the spacer layer is proposed. It is experimentally shown that, in the samples with a shallow quantum well, the AlAs nanobarrier introduced into the spacer layer provides a larger than threefold increase in the electron mobility at low temperatures.

  10. A Bibliography on the Black American.

    ERIC Educational Resources Information Center

    United States Air Forces in Europe, Wiesbaden (West Germany).

    This bibliography provides a comprehensive listing of book and audio-visual materials of interest to, by, and about Black Americans. Annotations are given for a majority of the books and selections are marked if they are recommended for all libraries or for large libraries. Books are listed under subject headings including: Africa, art, Black…

  11. Cooperative Cataloging of Latin-American Books: The Unfulfilled Promise.

    ERIC Educational Resources Information Center

    Grover, Mark L.

    1991-01-01

    Discussion of cooperative activities among libraries focuses on cataloging of Latin American materials among research libraries. Differences in motivation for cooperation in acquisitions and in cataloging are discussed; and a study is described that examined which libraries were providing online cataloging, and differences between OCLC and RLIN…

  12. African-American Literature: Finding Biographical and Critical Sources.

    ERIC Educational Resources Information Center

    Van Noate, Judith, Comp.

    This guide is intended to help library patrons of the Atkins Library (at the University of North Carolina Charlotte) find sources of criticism on African-American literature. The guide explains important reference sources in the reference collection of the library and how to find biographical and critical information in books and periodicals. The…

  13. Romantic American Literature: Sources for Criticism. A Research Guide.

    ERIC Educational Resources Information Center

    Van Noate, Judith, Comp.

    This handout is a guide to library resources in the J. Murrey Atkins Library at the University of North Carolina-Charlotte for the criticism of Romantic (19th century) American literature. The guide explains important reference sources in the Atkins library reference collection and how to find biographical and critical information in books and…

  14. Special Collections in Libraries in the United States. Bulletin, 1912, No. 23. Whole Number 495

    ERIC Educational Resources Information Center

    Johnston, W. Dawson; Mudge, Isadore G.

    1912-01-01

    This bulletin is virtually a new edition of the work entitled "Special collections of American libraries," by William Coolidge Lane and Charles Knowles Bolton, published in 1892. Since the publication of that most important contribution to American library literature there have been several surveys of a local character published. While these…

  15. Libraries, Ebooks, and Competition

    ERIC Educational Resources Information Center

    Hellman, Eric

    2010-01-01

    People keep writing articles about how valuable libraries are, even with ebooks and the Internet. What people are overlooking is that the reason libraries are having such fits dealing with a changing environment is not that libraries are unrecognized as fountains of value, it's that libraries are so valuable that they attract voracious new…

  16. The Library Building Tomorrow.

    ERIC Educational Resources Information Center

    Waters, Richard L.

    1987-01-01

    Examination of the library of tomorrow speculates about the impact of changes in the functions of government, technology, demographics, lifestyle, and values on the role of the library. A facility for the contemporary public library is described that can both accommodate traditional services and respond to changes in the library's role. (17…

  17. School Libraries in Hawaii.

    ERIC Educational Resources Information Center

    Bard, Therese Bissen

    This paper outlines the history, functions, administration, and current focus of school library services in Hawaii, which is the only state in the United States with a library staffed by a trained librarian in every public school. Its first school library was established in 1882. Elementary school libraries developed concurrently with secondary…

  18. California: Library Information Technologies.

    ERIC Educational Resources Information Center

    Will, Barbara, Ed.

    1996-01-01

    Describes six information technology projects in California libraries, including Internet access in public libraries; digital library developments at the University of California, Berkeley; the World Wide Web home page for the state library; Pacific Bell's role in statewide connectivity; state government initiatives; and services of the state…

  19. Economics of Academic Libraries.

    ERIC Educational Resources Information Center

    Baumol, William J.; Marcus, Matityahu

    An analysis is conducted of economic issues pertinent to library planning in higher education in the face of rising costs and diminishing financial support. The individual chapters deal with: 1) growth rates in large university libraries; 2) library costs in colleges and universities; 3) cost trends and long-range plans; 4) library data; and 5) a…

  20. Alaska Library Directory, 1996.

    ERIC Educational Resources Information Center

    Jennings, Mary, Ed.

    This directory of Alaska's Libraries lists: members of the Alaska Library Association (AkLA) Executive Council and Committee Chairs; State Board of Education members; members of the Governor's Advisory Council on Libraries; school, academic and public libraries and their addresses, phone and fax numbers, and contact persons; personal,…

  1. Growing Competition for Libraries.

    ERIC Educational Resources Information Center

    Gibbons, Susan

    2001-01-01

    Describes the Questia subscription-based online academic digital books library. Highlights include weaknesses of the collection; what college students want from a library; importance of marketing; competition for traditional academic libraries that may help improve library services; and the ability of Questia to overcome barriers and…

  2. The New Library Professional

    ERIC Educational Resources Information Center

    Wilder, Stanley

    2007-01-01

    This article discusses what the growing generation gap among library employees mean for academic research libraries and for the profession. Viewed collectively, the members of the under-35 cohort are a harbinger of a new kind of academic library professional, one whose traits bear directly on the ability of libraries to thrive amid the continuing…

  3. AMERICA 2000 Library Partnership.

    ERIC Educational Resources Information Center

    Office of Educational Research and Improvement (ED), Washington, DC.

    The United States Department of Education, the National Endowment for the Humanities, the Library of Congress, the National Commission on Libraries and Information Science, and the National Institute for Literacy have formed the AMERICA 2000 Library Partnership to support libraries in their work toward the six National Education Goals announced by…

  4. Conservation of Library Materials.

    ERIC Educational Resources Information Center

    Illinois Libraries, 1985

    1985-01-01

    Twelve articles cover books as artifacts; workstations for conservation of library materials; care of scrapbooks, albums, and photographs; map preservation; library environment; flood recovery; disaster prevention and preparedness; incorporating preservation into library organization; and bibliography of Chester Public Library (Illinois) First…

  5. The Bush Memorial Library.

    ERIC Educational Resources Information Center

    Hamline University Bulletin, 1971

    1971-01-01

    The Bush Memorial Library was formally dedicated on October 9, 1971. As part of Hamline University in St. Paul, Minnesota, the Bush Memorial Library has a reading room, audio booths, and audio-visual classroom as well as an audio control room. The Bush Memorial Library is a member of the Cooperating Libraries in Consortium which is a cooperative…

  6. The History and Role of Libraries in Adult Literacy

    ERIC Educational Resources Information Center

    Horning, Alice

    2010-01-01

    Illiteracy is a huge problem, socially, economically and educationally. This study of the history and current practices of American public libraries examines their role in supporting the development of human literate abilities and in helping all Americans to be critically literate in order to participate fully and successfully in our society. This…

  7. Using the "New Planning for Results" Process To Create Local Standards of Library Service.

    ERIC Educational Resources Information Center

    Kotch, Marianne

    2002-01-01

    Discusses "The New Planning for Results" manual published by the American Library Association that helps create local standards of public library service, and provides implementation examples based on experiences in Vermont. Highlights include evaluating community needs; service responses to those needs; developing library objectives; and…

  8. Tourist Attraction: The Moore Library of Lexington, Michigan, 1903-1953

    ERIC Educational Resources Information Center

    Wiegand, Wayne A.

    2011-01-01

    This essay challenges traditional assumptions about the small-town American public library and the roles it has played in its community. Conventional thinking and professional rhetoric grounded on a "user in the life of the library" perspective identifies the public library as a neutral agency "essential to democracy" that guards against…

  9. The ADA Library Kit: Sample ADA-Related Documents to Help You Implement the Law.

    ERIC Educational Resources Information Center

    Mayo, Kathleen, Ed.; O'Donnell, Ruth, Ed.

    The Association of Specialized and Cooperative Library Agencies (ASCLA) formed an Americans with Disabilities Act (ADA) Assembly in 1992, and one of its first projects was to prepare this publication by collecting samples of library-produced ADA-related documents. Its aim is to help libraries increase levels of compliance and public awareness. The…

  10. Vermont Public Library Almanac: A Compendium of Often-Answered Questions. 2nd Edition.

    ERIC Educational Resources Information Center

    Kotch, Marianne

    This document contains brief answers to some of the most frequently raised issues related to running a small Vermont public library. Areas covered include accessibility, the American Library Association, automation, awards, binding, services for the blind and physically handicapped, the Board of Libraries, the Board of Trustees, book dealers, book…

  11. Our National Monument of Art: Constructing and Debating the National Body at the Library of Congress

    ERIC Educational Resources Information Center

    Moore, Sarah J.

    2010-01-01

    It is not surprising that the Library of Congress would be defined as our national monument of art given the scale of the project, its federal sponsorship, and its posture as a public library with access to all Americans. Paralleling the assumption of the Library of Congress as not merely a building for housing books but a ritualistic center of…

  12. Library Outreach to Juvenile Offenders in Intensive Supervision Probation Programs (Community Centered House Arrest)

    ERIC Educational Resources Information Center

    Brumfield, Elizabeth Jean

    2008-01-01

    The American Library Association encourages public libraries to extend their services to people in jails and detention centers, but there is little research that shows exactly how many libraries do so. Research shows that 54% of juveniles arrested are not sent to residential facilities but instead receive court ordered probation into an Intensive…

  13. 5-ALA Fluorescence Image Guided Resection of Glioblastoma Multiforme: A Meta-Analysis of the Literature

    PubMed Central

    Eljamel, Samy

    2015-01-01

    Background: Glioblastoma multiforme (GBM) is one of the most deadly cancers in humans. Despite recent advances in anti-cancer therapies, most patients with GBM die from local disease progression. Fluorescence image guided surgical resection (FIGR) was recently advocated to enhance local control of GBM. This is meta-analyses of 5-aminolevulinic (5-ALA) induced FIGR. Materials: Review of the literature produced 503 potential publications; only 20 of these fulfilled the inclusion criteria of this analysis, including a total of 565 patients treated with 5-ALA-FIGR reporting on its outcomes and 800 histological samples reporting 5-ALA-FIGR sensitivity and specificity. Results: The mean gross total resection (GTR) rate was 75.4% (95% CI: 67.4–83.5, p < 0.001). The mean time to tumor progression (TTP) was 8.1 months (95% CI: 4.7–12, p < 0.001). The mean overall survival gain reported was 6.2 months (95% CI: −1–13, p < 0.001). The specificity was 88.9% (95% CI: 83.9–93.9, p < 0.001) and the sensitivity was 82.6% (95% CI: 73.9–91.9, p < 0.001). Conclusion: 5-ALA-FIGR in GBM is highly sensitive and specific, and imparts significant benefits to patients in terms of improved GTR and TTP. PMID:25961952

  14. Theoretical site-directed mutagenesis: Asp168Ala mutant of lactate dehydrogenase

    PubMed Central

    Ferrer, Silvia; Tuñón, Iñaki; Moliner, Vicent; Williams, Ian H.

    2008-01-01

    Molecular simulations based on the use of hybrid quantum mechanics/molecular mechanics methods are able to provide detailed information about the complex enzymatic reactions and the consequences of specific mutations on the activity of the enzyme. In this work, the reduction of pyruvate to lactate catalysed by wild-type and Asp168Ala mutant lactate dehydrogenase (LDH) has been studied by means of simulations using a very flexible molecular model consisting of the full tetramer of the enzyme, together with the cofactor NADH, the substrate and solvent water molecules. Our results indicate that the Asp168Ala mutation provokes a shift in the pKa value of Glu199 that becomes unprotonated at neutral pH in the mutant enzyme. This change compensates the loss of the negative charge of Asp168, rendering a still active enzyme. Thus, our methodology gives a calculated barrier height for the Asp168Ala mutant 3 kcal mol−1 higher than that for wild-type LDH, which is in very good agreement with the experiment. The computed potential energy surfaces reveal the reaction pathways and transition structures for the wild-type and mutant enzymes. Hydride transfer is less advanced and the proton transfer is more advanced in the Asp168Ala mutant than in the wild type. This approach provides a very powerful tool for the analysis of the roles of key active-site residues. PMID:18682365

  15. ALA-PDT mediated DC vaccine for skin squamous cell carcinoma

    NASA Astrophysics Data System (ADS)

    Ji, Jie; Fan, Zhixia; Zhou, Feifan; Wang, Xiaojie; Shi, Lei; Zhang, Haiyan; Wang, Peiru; Yang, Degang; Zhang, Linglin; Wang, Xiuli; Chen, Wei R.

    2015-03-01

    Dendritic cell (DC) based vaccine has emerged as a promising immunotherapy for cancers. However, most DC vaccines so far have only achieved limited success in cancer treatment. Photodynamic therapy (PDT), an established cancer treatment strategy, can cause immunogenic apoptosis to induce an effective antitumor immune response. In this study, we developed a DC-based cancer vaccine using immunogenic apoptotic tumor cells induced by 5-aminolevulinic acid (ALA) mediated PDT. The maturation of DCs induced by PDT-treated apoptotic cells was evaluated. The anti-tumor immunity of ALA-PDT-DC vaccine was tested with mouse model. We observed the maturations of DCs potentiated by ALA-PDT treated tumor cells, including phenotypic maturation (upregulation of surface expression of MHC-II, DC80, and CD86), and functional maturation (enhanced capability to secret INF-Υ and IL-12). ALA-PDT-DC vaccine mediated by apoptotic cells provided protection against tumor in mice, far stronger than that of DC vaccine obtained from freeze/thaw treated tumor cells. Our results indicate that immunogenic apoptotic tumor cells can be more effective in enhancing DC-based cancer vaccine, which could improve the clinical application of PDT- DC vaccines.

  16. Studying Online: Student Motivations and Experiences in ALA-Accredited LIS Programs

    ERIC Educational Resources Information Center

    Oguz, Fatih; Chu, Clara M.; Chow, Anthony S.

    2015-01-01

    This paper presents a large scale study of online MLIS students (n = 910), who completed at least one online course and were enrolled in 36 of the 58 ALA-accredited MLIS programs in Canada and the United States. The results indicate that the typical student is female, White, lives in an urban setting, and is in her mid-30s. Online students were…

  17. Preservice Legal Education for Academic Librarians within ALA-Accredited Degree Programs

    ERIC Educational Resources Information Center

    Cross, William M.; Edwards, Phillip M.

    2011-01-01

    In order to explore the current state of legal education for graduates of LIS programs, we present the results of an examination of the curricula and faculty composition at all 57 institutions that offer ALA-accredited graduate degrees. Concluding that, even under the best circumstances, many students graduate with a limited understanding of legal…

  18. Evidence of fully spin polarized ν = 3 in single valley (110)-AlAs quantum wells

    NASA Astrophysics Data System (ADS)

    Prabhu-Gaunkar, S.; Grayson, M.; Dasgupta, S.; Bichler, M.; Morral, A. Fontcuberta I.; Abstreiter, G.

    2010-03-01

    We observe a spike in the longitudinal resistance of a single valley (110)-AlAs quantum well between ν = 3 and 4 which is interpreted as evidence of a quantum Hall ferromagnetic transition. This feature occurs at a magnetic field B = 2.85 T in a sample with densities n = 1.5 - 2.17x10^11 cm-2 in a perpendicular field with no external strain. The spike disappears on further lowering the density of the sample or on raising its temperature above 600 mK. The spike also shows magnetic hysteresis. Since AlAs is a heavy mass system, the exchange enhanced Zeeman energies become comparable to the cyclotron energies and can lead to Landau level crossings even in a purely perpendicular magnetic field. Being a single valley system, there are fewer quantum numbers for the Landau levels than in standard (001) double-valley AlAs wells, and exchange interactions can reorder the levels differently. The spike feature may suggest that up to three completely spin polarized levels exist before the occupation of minority spin levels lowers the exchange interaction energy causing the ground state transition. The (110)-AlAs quantum wells may thus be particularly suited to study exchange enhancement effects.

  19. X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation

    PubMed Central

    Sankaran, Vijay G.; Ulirsch, Jacob C.; Tchaikovskii, Vassili; Ludwig, Leif S.; Wakabayashi, Aoi; Kadirvel, Senkottuvelan; Lindsley, R. Coleman; Bejar, Rafael; Shi, Jiahai; Lovitch, Scott B.; Bishop, David F.; Steensma, David P.

    2015-01-01

    Macrocytic anemia with abnormal erythropoiesis is a common feature of megaloblastic anemias, congenital dyserythropoietic anemias, and myelodysplastic syndromes. Here, we characterized a family with multiple female individuals who have macrocytic anemia. The proband was noted to have dyserythropoiesis and iron overload. After an extensive diagnostic evaluation that did not provide insight into the cause of the disease, whole-exome sequencing of multiple family members revealed the presence of a mutation in the X chromosomal gene ALAS2, which encodes 5′-aminolevulinate synthase 2, in the affected females. We determined that this mutation (Y365C) impairs binding of the essential cofactor pyridoxal 5′-phosphate to ALAS2, resulting in destabilization of the enzyme and consequent loss of function. X inactivation was not highly skewed in wbc from the affected individuals. In contrast, and consistent with the severity of the ALAS2 mutation, there was a complete skewing toward expression of the WT allele in mRNA from reticulocytes that could be recapitulated in primary erythroid cultures. Together, the results of the X inactivation and mRNA studies illustrate how this X-linked dominant mutation in ALAS2 can perturb normal erythropoiesis through cell-nonautonomous effects. Moreover, our findings highlight the value of whole-exome sequencing in diagnostically challenging cases for the identification of disease etiology and extension of the known phenotypic spectrum of disease. PMID:25705881

  20. No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome.

    PubMed

    Miyata, Toshiyuki; Uchida, Yumiko; Yoshida, Yoko; Kato, Hideki; Matsumoto, Masanori; Kokame, Koichi; Fujimura, Yoshihiro; Nangaku, Masaomi

    2016-08-01

    Atypical hemolytic uremic syndrome (aHUS), a form of thrombotic microangiopathy, is caused by the uncontrolled activation of the alternative pathway of complement on the cell surface that leads to microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. A recent genetic analysis of aHUS patients identified deleterious mutations not only in complement or complement regulatory genes but also in the plasminogen gene, suggesting that subnormal plasminogen activity may be related to the degradation of thrombi in aHUS. Dysplasminogenemia, which is caused by a genetic variant in the plasminogen gene, PLG:p.Ala620Thr, is commonly observed in the northeast Asian populations, including Japanese. To examine the association between dysplasminogenemia and aHUS, we genotyped PLG:p.Ala620Thr in 103 Japanese patients with aHUS. We identified five aHUS patients with PLG:p.Ala620Thr; the minor allele frequency (MAF) was thus 0.024. The MAF in the patient group was not significantly different from those obtained from a general Japanese population (MAF = 0.020) and the Japanese genetic variation HGDV database (MAF = 0.021) (P = 0.62 and 0.61, respectively). We concluded that, although carriers with PLG:p.Ala620Thr show low plasminogen activity, this is not a predisposing variant for aHUS and that individuals of dysplasminogenemia are not at significantly increased risk of aHUS. PMID:27194432

  1. Potentiation of ALA-PDT antitumor activity in mice using topical DMXAA

    NASA Astrophysics Data System (ADS)

    Marrero, Allison; Sunar, Ulas; Sands, Theresa; Oseroff, Allan; Bellnier, David

    2009-06-01

    Photodynamic treatment of subcutaneously implanted Colon 26 tumors in BALB/c mice using the aminolevulinic acid (ALA)-induced photosensitizer protoporphyrin IX (PpIX) was shown to be enhanced by the addition of the vascular disrupting agent 5,6-Dimethylxanthenone-4-acetic-acid (DMXAA; Novartis ASA404). DMXAA increases vascular permeability and decreases blood flow in both murine and human tumors. Sufficiently high parenteral DMXAA doses can lead to tumor collapse and necrosis. We have previously reported marked enhancement of antitumor activity when PDT, using either Photofrin or HPPH, is combined with low-dose intraperitoneal DMXAA. We now describe the first attempt to combine topically-applied DMXAA with PDT. For this, DMXAA was applied two hours before PpIX-activating light delivery. PDT with ALA-PDT alone (ALA 20%; 80 J/cm2 delivered at 75 mW/cm2) caused a 39% decrease in tumor volume compared to unirradiated controls. Addition of topical DMXAA to ALA-PDT resulted in a 74% reduction in tumor volume. Diffuse correlation spectroscopy (DCS), a non-invasive blood flow imaging method, is being used to understand the mechanism of this effect and to aid in the proper design of the therapy. For instance, our most recent DCS data suggests that the 2-hour interval between the DMXAA and light applications may not be optimum. This preliminary study suggests a potential role for topical DMXAA in combination with PDT for dermatologic tumors.

  2. Effect of Surfactants on Production of Oxygenated Unsaturated Fatty Acids by Bacillus megaterium ALA2

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bacillus megaterium ALA2 (NRRL B-21660) produces many oxygenated unsaturated fatty acids from linoleic acid. Its major product, 12,13,17-trihydroxy-9(Z)-octadecenoic acid (12,13,17-THOA), inhibits the growth of some plant pathogenic fungi. Because hydrophobic fatty acids need to be evenly disperse...

  3. Enhancing (L)-isoleucine production by thrABC overexpression combined with alaT deletion in Corynebacterium glutamicum.

    PubMed

    Wang, Jing; Wen, Bing; Wang, Jian; Xu, Qingyang; Zhang, Chenglin; Chen, Ning; Xie, Xixian

    2013-09-01

    L-isoleucine is synthesized from 2-ketobutyrate and pyruvate in Corynebacterium glutamicum, and the supplies of these two precursors are important for L-isoleucine synthesis. C. glutamicum YILWΔalaT with alaT gene deletion (encoding alanine aminotransferase, a principal enzyme for L-alanine synthesis) was constructed to increase intracellular pyruvate availability, and the thrABC genes from Escherichia coli (encoding bifunctional aspartate kinase I-homoserine dehydrogenase I, homoserine kinase, and threonine synthetase) were overexpressed in C. glutamicum YILW and YILWΔalaT to increase the supply of intracellular 2-ketobutyrate. In the fed-batch fermentation, YILWpXMJ19thrABC, YILWΔalaT, and YILWΔalaTpXMJ19thrABC exhibited 5.3, 17.6, and 8.4 % higher L-isoleucine production than the original strain, respectively. Both YILWpXMJ19thrABC and YILWΔalaT excreted lower concentrations of L-lysine, L-alanine, and L-valine. YILWΔalaTpXMJ19thrABC exhibited a cumulative reduction of these by-products excretion, which indicated that thrABC overexpression combined with alaT deletion resulted in the metabolic flux redistribution from 2-ketobutyrate and pyruvate to L-isoleucine synthesis, and decreased the fluxes to by-products synthesis accordingly. PMID:23813403

  4. 78 FR 14414 - The Alabama Great Southern Railroad Company-Abandonment Exemption-in Gadsden, Etowah County, Ala...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Gadsden, Etowah County, Ala.; Tennessee, Alabama, and Georgia Railway Company--Abandonment Exemption--in Gadsden, Etowah County, AL The Alabama Great Southern Railroad Company (AGS) and Tennessee, Alabama, and... approximately 4.25 miles of interconnected rail line in Gadsden, Etowah County, Ala. Specifically, AGS...

  5. Combination Nasolabial Transposition Flap and Island Pedicle Flap Following Mohs Surgery of Simultaneous Basal Cell Carcinomas Involving Both Nasal Alae

    PubMed Central

    Lee, Chae Young; Lee, Yeong Kyu; Choi, Kyu Won; Lee, Chae Wook; Kim, Ki Ho

    2008-01-01

    The nasal ala is a challenging area for surgical reconstruction, with thick sebaceous skin, the lack of an ample tissue reservoir, and an adjacent free margin. Numerous flaps have been reported for the repair of alae defects. A 71-year-old woman with simultaneous basal cell carcinomas involving both nasal alae was treated by Mohs micrographic surgery. The surgical defects measured 1.5×1.5 cm on the center of the right nasal ala and 1.0×1.0 cm on the left nasal ala, including the alar crease and rim. The right nasal ala was used as a nasolabial transposition flap and the left nasal ala was reconstructed by an island pedicle flap. The final shape and texture were satisfactory. The flaps survived and nasal symmetry was preserved. Combined nasolabial transposition and island pedicle flaps thus offer a superior esthetic and functional result owing to minimized tension. This may be a valuable reconstructive option in the repair of bilateral nasal alae defects.

  6. Substitution of the Lys Linker with the β-Ala Linker Dramatically Decreased the Renal Uptake of 99mTc-Labeled Arg-X-Asp-Conjugated and X-Ala-Asp-Conjugated α-Melanocyte Stimulating Hormone Peptides

    PubMed Central

    2015-01-01

    The purpose of this study was to examine whether the substitution of the Lys linker with the β-Ala could reduce the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated α-melanocyte stimulating hormone (α-MSH) peptides. RSD-β-Ala-(Arg11)CCMSH (1) {c[Arg-Ser-Asp-dTyr-Asp]-β-Ala-Cys-Cys-Glu-His-dPhe-Arg-Trp-Cys-Arg-Pro-Val-NH2}, RTD-β-Ala-(Arg11)CCMSH (2), RVD-β-Ala-(Arg11)CCMSH (3), RAD-β-Ala-(Arg11)CCMSH (4), NAD-β-Ala-(Arg11)CCMSH (5), and EAD-β-Ala-(Arg11)CCMSH (6) peptides were synthesized and evaluated for their melanocortin 1 (MC1) receptor binding affinities in B16/F1 melanoma cells. The biodistribution of their 99mTc-conjugates were determined in B16/F1 melanoma-bearing C57 mice. The substitution of the Lys linker with β-Ala linker dramatically reduced the renal uptake of all six 99mTc-peptides. 99mTc-4 exhibited the highest melanoma uptake (15.66 ± 6.19% ID/g) and the lowest kidney uptake (20.18 ± 3.86% ID/g) among these 99mTc-peptides at 2 h postinjection. The B16/F1 melanoma lesions could be clearly visualized by single photon emission computed tomography (SPECT)/CT using 99mTc-4 as an imaging probe. PMID:25290883

  7. America's Star Libraries, 2010: Top-Rated Libraries

    ERIC Educational Resources Information Center

    Lyons, Ray; Lance, Keith Curry

    2010-01-01

    The "LJ" Index of Public Library Service 2010, "Library Journal"'s national rating of public libraries, identifies 258 "star" libraries. Created by Ray Lyons and Keith Curry Lance, and based on 2008 data from the IMLS, it rates 7,407 public libraries. The top libraries in each group get five, four, or three stars. All included libraries, stars or…

  8. ALA-mediated photodynamic therapy of experimental malignant glioma in the BD-IX rat model

    NASA Astrophysics Data System (ADS)

    Hirschberg, Henry; Angell-Petersen, Even; Peng, Qian; Sun, Chung-Ho; Sorensen, Dag R.; Carper, Steven W.; Madsen, Steen J.

    2005-04-01

    Introduction: Failure of treatment for high grade gliomas is usually due to local recurrence at the site of surgical resec-tion indicating that a more aggressive form of local therapy could be of benefit. Photodynamic therapy (PDT) is a local form of treatment involving the administration of a tumor-localizing photosensitizing drug that is activated by light of a specific wavelength The results of in vitro experiments indicated that PDT, given at low fluence rates was substantially more effective at inhibiting glioma spheroid growth than short term high fluence rate regimes. This prompted the initia-tion of in vivo studies of low fluence rate 5-aminolevulinic acid (ALA) PDT in a rat glioma model. Methods:BT4C cell line tumors were established in the brains of inbred BD- IX rats. Eighteen days following tumor induction the animals were injected with 125 mg/kg ALA ip. and four hours later light treatment at various fluences and fluence rates were given after the introduction of an optical fiber. Tumor histology and animal survival were examined. Results: In vitro experiments verified that the cell line was sensitive to ALA PDT. Microfluorometry of frozen tissue sections showed that PpIX is produced with a greater than 20:1 tumor to normal tissue selectivity ratio four hours after ALA injection. Histological examination demonstrated neutrophil infiltration and tumor central necrosis in low fluence rate treated tumors. Conclusions: Low fluence rate long term ALA mediated PDT had a more pronounced effect on tumor histology than single shot short duration treatments at similar total fluence levels.

  9. Guidelines for Holding a Governor's Conference on Libraries: A Step-by-Step How to Do It Manual. ALTA Publication Number Three.

    ERIC Educational Resources Information Center

    Lynch, Mrs. Weldon

    This document is a revision of "Guidelines for Holding a Governor's Conference on Libraries (American Library Association, American Trustee Association, 1963). The report discusses what governor's conferences on libraries are and how they may be helpful. Many aspects of planning for such a conference are presented, including how much time to leave…

  10. Authoritarianism and Censorship: Attitudes and Opinions of Students in the Graduate Library School of Indiana University. A Report of an Exploratory Project Conducted as a Preliminary for a Proposed Nationwide Study of American Public Librarians and Intellectual Freedom.

    ERIC Educational Resources Information Center

    Busha, Charles H.

    This study attempts to measure the attitudes toward intellectual freedom held by a group of future librarians and to correlate these findings with certain syndromes of authoritarianism as reported in "The Authoritarian Personality," by T. W. Adorno, and others (New York, Harper, 1950). The hypothesis is that graduate library students who express…

  11. School Libraries Count! The Second National Survey of School Library Media Programs, 2008

    ERIC Educational Resources Information Center

    American Association of School Librarians (NJ1), 2008

    2008-01-01

    In 2007, the American Association of School Librarians (AASL) initiated an annual survey of school library media programs. The development of this longitudinal survey project was mandated by the AASL Board and advocated by the division's Research and Statistics Committee and Independent Schools Section. The launch of the second year of the survey…

  12. Characterization of the Ala62Pro polymorphic variant of human cytochrome P450 1A1 using recombinant protein expression

    SciTech Connect

    Lee, Seung Heon; Kang, Sukmo; Dong, Mi Sook; Park, Jung-Duck; Park, Jinseo; Rhee, Sangkee; Ryu, Doug-Young

    2015-06-15

    Cytochrome P450 (CYP) 1A1 is a heme-containing enzyme involved in detoxification of hydrophobic pollutants. Its Ala62Pro variant has been identified previously. Ala62 is located in α-helix A of CYP1A1. Residues such as Pro and Gly are α-helix breakers. In this study, the Ala62Pro variant was characterized using heterologous expression. E. coli expressing the Ala62Pro variant, and the purified variant protein, had lower CYP (i.e. holoenzyme) contents than their wild-type (WT) equivalents. The CYP variant from E. coli and mammalian cells exhibited lower 7-ethoxyresorufin O-dealkylation (EROD) and benzo[a]pyrene hydroxylation activities than the WT. Enhanced supplementation of a heme precursor during E. coli culture did not increase CYP content in E. coli expressing the variant, but did for the WT. As for Ala62Pro, E. coli expressing an Ala62Gly variant had a lower CYP content than the WT counterpart, but substitution of Ala62 with α-helix-compatible residues such as Ser and Val partially recovered the level of CYP produced. Microsomes from mammalian cells expressing Ala62Pro and Ala62Gly variants exhibited lower EROD activities than those expressing the WT or Ala62Val variant. A region harboring α-helix A has interactions with another region containing heme-interacting residues. Site-directed mutagenesis analyses suggest the importance of interactions between the two regions on holoenzyme expression. Together, these findings suggest that the Ala62Pro substitution leads to changes in protein characteristics and function of CYP1A1 via structural disturbance of the region where the residue is located. - Highlights: • Ala62 is located in α-helix A of the carcinogen-metabolizing enzyme CYP1A1. • Pro acts as an α-helix breaker. • A variant protein of CYP1A1, Ala62Pro, had lower heme content than the wild-type. • The variant of CYP1A1 had lower enzyme activities than the wild-type.

  13. Afro-American Studies: A Research Guide. 1992 Edition.

    ERIC Educational Resources Information Center

    Van Noate, Judith E., Comp.

    This guide has been prepared to enable students at the University of North Carolina at Charlotte to locate material on topics in Afro-American studies or topics with Afro-American emphasis in the J. Murrey Atkins Library. Although a number of sources listed within the guide relate specifically to Afro-American studies, many others treat the black…

  14. Art Libraries Section. Special Libraries Division. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Papers on art libraries and information services for the arts, which were presented at the 1983 International Federation of Library Associations (IFLA) conference, include: (1) "'I See All': Information Technology and the Universal Availability of Images" by Philip Pacey (United Kingdom); (2) "Online Databases in the Fine Arts" by Michael Rinehart…

  15. The Libraries of Rio.

    ERIC Educational Resources Information Center

    Foster, Barbara

    1988-01-01

    Describes aspects of several libraries in Rio de Janeiro. Topics covered include library policies, budgets, periodicals and books in the collections, classification schemes used, and literary areas of interest to patrons. (6 references) (CLB)

  16. Facility Focus: Libraries.

    ERIC Educational Resources Information Center

    College Planning & Management, 2003

    2003-01-01

    Describes the designs of the Ferris State University Library for Information, Technology and Education (FLITE), and the Meyer Library and Information Technology Center at Southwest Missouri State University. Includes photographs. (EV)

  17. Selecting Library Furniture & Equipment.

    ERIC Educational Resources Information Center

    Media & Methods, 1997

    1997-01-01

    Offers suggestions for selecting school library furniture and equipment. Describes various models of computer workstations; reading tables and chairs; and shelving. Sidebar lists names and addresses of library furniture manufactures and distributors. (AEF)

  18. Medical Library Association

    MedlinePlus

    ... 11th, 2016 Patricia Flatley Brennan, registered nurse, informatician, industrial engineer, and renowned researcher is appointed as Director of the National Library of Medicine Tweets Copyright © 2016 Medical Library Association. ...

  19. Israeli Special Libraries

    ERIC Educational Resources Information Center

    Foster, Barbara

    1974-01-01

    Israel is sprinkled with a noteworthy representation of special libraries which run the gamut from modest kibbutz efforts to highly technical scientific and humanities libraries. A few examples are discussed here. (Author/CH)

  20. Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification.

    PubMed

    Chan, Amy; Liebow, Abigail; Yasuda, Makiko; Gan, Lin; Racie, Tim; Maier, Martin; Kuchimanchi, Satya; Foster, Don; Milstein, Stuart; Charisse, Klaus; Sehgal, Alfica; Manoharan, Muthiah; Meyers, Rachel; Fitzgerald, Kevin; Simon, Amy; Desnick, Robert J; Querbes, William

    2015-01-01

    The acute hepatic porphyrias are caused by inherited enzymatic deficiencies in the heme biosynthesis pathway. Induction of the first enzyme 5-aminolevulinic acid synthase 1 (ALAS1) by triggers such as fasting or drug exposure can lead to accumulation of neurotoxic heme intermediates that cause disease symptoms. We have demonstrated that hepatic ALAS1 silencing using siRNA in a lipid nanoparticle effectively prevents and treats induced attacks in a mouse model of acute intermittent porphyria. Herein, we report the development of ALN-AS1, an investigational GalNAc-conjugated RNAi therapeutic targeting ALAS1. One challenge in advancing ALN-AS1 to patients is the inability to detect liver ALAS1 mRNA in the absence of liver biopsies. We here describe a less invasive circulating extracellular RNA detection assay to monitor RNAi drug activity in serum and urine. A striking correlation in ALAS1 mRNA was observed across liver, serum, and urine in both rodents and nonhuman primates (NHPs) following treatment with ALN-AS1. Moreover, in donor-matched human urine and serum, we demonstrate a notable correspondence in ALAS1 levels, minimal interday assay variability, low interpatient variability from serial sample collections, and the ability to distinguish between healthy volunteers and porphyria patients with induced ALAS1 levels. The collective data highlight the potential utility of this assay in the clinical development of ALN-AS1, and in broadening our understanding of acute hepatic porphyrias disease pathophysiology. PMID:26528940

  1. Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

    PubMed Central

    Chan, Amy; Liebow, Abigail; Yasuda, Makiko; Gan, Lin; Racie, Tim; Maier, Martin; Kuchimanchi, Satya; Foster, Don; Milstein, Stuart; Charisse, Klaus; Sehgal, Alfica; Manoharan, Muthiah; Meyers, Rachel; Fitzgerald, Kevin; Simon, Amy; Desnick, Robert J; Querbes, William

    2015-01-01

    The acute hepatic porphyrias are caused by inherited enzymatic deficiencies in the heme biosynthesis pathway. Induction of the first enzyme 5-aminolevulinic acid synthase 1 (ALAS1) by triggers such as fasting or drug exposure can lead to accumulation of neurotoxic heme intermediates that cause disease symptoms. We have demonstrated that hepatic ALAS1 silencing using siRNA in a lipid nanoparticle effectively prevents and treats induced attacks in a mouse model of acute intermittent porphyria. Herein, we report the development of ALN-AS1, an investigational GalNAc-conjugated RNAi therapeutic targeting ALAS1. One challenge in advancing ALN-AS1 to patients is the inability to detect liver ALAS1 mRNA in the absence of liver biopsies. We here describe a less invasive circulating extracellular RNA detection assay to monitor RNAi drug activity in serum and urine. A striking correlation in ALAS1 mRNA was observed across liver, serum, and urine in both rodents and nonhuman primates (NHPs) following treatment with ALN-AS1. Moreover, in donor-matched human urine and serum, we demonstrate a notable correspondence in ALAS1 levels, minimal interday assay variability, low interpatient variability from serial sample collections, and the ability to distinguish between healthy volunteers and porphyria patients with induced ALAS1 levels. The collective data highlight the potential utility of this assay in the clinical development of ALN-AS1, and in broadening our understanding of acute hepatic porphyrias disease pathophysiology. PMID:26528940

  2. Metallopolymer-peptide conjugates: synthesis and self-assembly of polyferrocenylsilane graft and block copolymers containing a beta-sheet forming Gly-Ala-Gly-Ala tetrapeptide segment.

    PubMed

    Vandermeulen, Guido W M; Kim, Kyoung Taek; Wang, Zhuo; Manners, Ian

    2006-04-01

    We describe the synthesis and self-assembly of two beta-sheet forming metallopolymer-peptide conjugates. The ability of the oligotetrapeptide sequence Gly-Ala-Gly-Ala (GAGA) to form antiparallel beta-sheets was retained in PFS-b-AGAG (PFS = polyferrocenylsilane) and PFS-g-AGAG conjugates with block and graft architectures, respectively. In the solid state, DSC experiments suggest a phase separation between the peptide and PFS domains. In toluene, PFS-b-AGAG interestingly forms a fibrous network which consists of a core containing the self-assembled antiparallel beta-sheet peptide and a corona of organometallic PFS. The self-assembly of the peptide into antiparallel beta-sheets is the driving force for the fiber formation, whereas PFS prevents uncontrolled lateral aggregation of the fibers. The use of an oligopeptide to self-assemble an otherwise random coiled organometallic polymer may be a useful strategy to enhance nanostructure formation. In the cases described here, the conjugates may be used to create nanopatterned ceramics, and the redox properties of the resulting supramolecular aggregates are of significant interest. PMID:16602714

  3. ALA Inhibits ABA-induced Stomatal Closure via Reducing H2O2 and Ca(2+) Levels in Guard Cells.

    PubMed

    An, Yuyan; Liu, Longbo; Chen, Linghui; Wang, Liangju

    2016-01-01

    5-Aminolevulinic acid (ALA), a newly proved natural plant growth regulator, is well known to improve plant photosynthesis under both normal and stressful conditions. However, its underlying mechanism remains largely unknown. Stomatal closure is one of the major limiting factors for photosynthesis and abscisic acid (ABA) is the most important hormone in provoking stomatal closing. Here, we showed that ALA significantly inhibited ABA-induced stomatal closure using wild-type and ALA-overproducing transgenic Arabidopsis (YHem1). We found that ALA decreased ABA-induced H2O2 and cytosolic Ca(2+) accumulation in guard cells with stomatal bioassay, laser-scanning confocal microscopy and pharmacological methods. The inhibitory effect of ALA on ABA-induced stomatal closure was similar to that of AsA (an important reducing substrate for H2O2 removal), CAT (a H2O2-scavenging enzyme), DPI (an inhibitor of the H2O2-generating NADPH oxidase), EGTA (a Ca-chelating agent), and AlCl3 (an inhibitor of calcium channel). Furthermore, ALA inhibited exogenous H2O2- or Ca(2+)-induced stomatal closure. Taken together, we conclude that ALA inhibits ABA-induced stomatal closure via reducing H2O2, probably by scavenging, and Ca(2+) levels in guard cells. Moreover, the inhibitive effect of ALA on ABA-induced stomatal closure was further confirmed in the whole plant. Finally, we demonstrated that ALA inhibits stomatal closing, but significantly improves plant drought tolerance. Our results provide valuable information for the promotion of plant production and development of a sustainable low-carbon society. PMID:27148309

  4. ALA Inhibits ABA-induced Stomatal Closure via Reducing H2O2 and Ca2+ Levels in Guard Cells

    PubMed Central

    An, Yuyan; Liu, Longbo; Chen, Linghui; Wang, Liangju

    2016-01-01

    5-Aminolevulinic acid (ALA), a newly proved natural plant growth regulator, is well known to improve plant photosynthesis under both normal and stressful conditions. However, its underlying mechanism remains largely unknown. Stomatal closure is one of the major limiting factors for photosynthesis and abscisic acid (ABA) is the most important hormone in provoking stomatal closing. Here, we showed that ALA significantly inhibited ABA-induced stomatal closure using wild-type and ALA-overproducing transgenic Arabidopsis (YHem1). We found that ALA decreased ABA-induced H2O2 and cytosolic Ca2+ accumulation in guard cells with stomatal bioassay, laser-scanning confocal microscopy and pharmacological methods. The inhibitory effect of ALA on ABA-induced stomatal closure was similar to that of AsA (an important reducing substrate for H2O2 removal), CAT (a H2O2-scavenging enzyme), DPI (an inhibitor of the H2O2-generating NADPH oxidase), EGTA (a Ca-chelating agent), and AlCl3 (an inhibitor of calcium channel). Furthermore, ALA inhibited exogenous H2O2- or Ca2+-induced stomatal closure. Taken together, we conclude that ALA inhibits ABA-induced stomatal closure via reducing H2O2, probably by scavenging, and Ca2+ levels in guard cells. Moreover, the inhibitive effect of ALA on ABA-induced stomatal closure was further confirmed in the whole plant. Finally, we demonstrated that ALA inhibits stomatal closing, but significantly improves plant drought tolerance. Our results provide valuable information for the promotion of plant production and development of a sustainable low-carbon society. PMID:27148309

  5. American Women and American Studies.

    ERIC Educational Resources Information Center

    Chmaj, Betty E.

    The American Studies Association (ASA) is an interprofessional group, representing a cross-section of persons from American literature, American history, the social sciences, philosophy, archeology, Black Studies, Urban Studies, American Studies, and others. This document by the ASA Commission on the Status of Women includes: (1) a report of the…

  6. Bookmarking Your Library's Teens.

    ERIC Educational Resources Information Center

    Williams, Mary Pasek

    1999-01-01

    Describes one public library's project of photographing teenagers reading around the library and making the photos into bookmarks with the library logo and a "read" message. Discusses the background, arrangements, photo session, assembly, distribution and publicity, and funding and community response. (AEF)

  7. The End of Libraries.

    ERIC Educational Resources Information Center

    Thompson, James

    1983-01-01

    Suggests that if librarians and libraries are to continue to fulfill their true tasks, they need to adapt to changes resulting from new technology and overcome the professional paralysis that has made most major libraries largely unusable. Problems of size, arrangement, and catalogs are identified as contributors to unusable library. (EJS)

  8. Library Studies I Workbook.

    ERIC Educational Resources Information Center

    Frost, William J.

    Developed for use in the Library Studies I component of the Library Studies Program at Bloomsburg University (Pennsylvania), this self-paced workbook is intended to acquaint students with the Harvey A. Andruss Library and help them develop information-seeking skills. The workbook is designed to be used in conjunction with an exercise book, and…

  9. Art for Libraries' Sake.

    ERIC Educational Resources Information Center

    Lugo, Mark-Elliot

    1999-01-01

    Illustrates the benefits of an aggressive library program of regularly scheduled and professionally curated art exhibitions and related events. Describes the Visual Arts Program at the Pacific Beach branch library (San Diego). A sidebar by Debra Wilcox Johnson discusses libraries' development of cultural programming for adults. (AEF)

  10. California Library Laws, 2009

    ERIC Educational Resources Information Center

    Smith, Paul G., Ed.

    2009-01-01

    California Library Laws 2009 is a selective guide to state laws and related materials that most directly affect the everyday operations of public libraries and organizations that work with public libraries. It is intended as a convenient reference, not as a replacement for the annotated codes or for legal advice. The guide is organized as follows.…

  11. California Library Laws, 2008

    ERIC Educational Resources Information Center

    Smith, Paul G., Ed.

    2008-01-01

    "California Library Laws 2008" is a selective guide to state laws and related materials that most directly affect the everyday operations of public libraries and organizations that work with public libraries. It is intended as a convenient reference, not as a replacement for the annotated codes or for legal advice. The guide is organized as…

  12. A Library That Swings

    ERIC Educational Resources Information Center

    Spragens, Thomas A.

    1971-01-01

    The Grace Doherty Library (Centre College, Danville, Kentucky) is a library that "swings," being so designed that a substantial part of its space is used alternately for classroom purposes during the day and for library reading-study space in the peak evening hours. (Author)

  13. School Libraries in Fiji.

    ERIC Educational Resources Information Center

    Singh, Harry

    1995-01-01

    Presents a 50-year history of school library development and national educational programs in Fiji and discusses the future of Fiji's elementary and secondary school libraries. Examines obstacles to school library development including government ignorance, lack of trained librarians, changes in school curriculum, lack of financing, and high costs…

  14. Marketing Academic Libraries

    ERIC Educational Resources Information Center

    Mallon, Melissa, Ed.

    2013-01-01

    Ask any academic librarian if marketing their library and its services is an important task, and the answer will most likely be a resounding "yes!" Particularly in economically troubled times, librarians are increasingly called upon to promote their services and defend their library's worth. Since few academic libraries have in-house marketing…

  15. The Toy Lending Library.

    ERIC Educational Resources Information Center

    Wiscont, Jeanne Mull

    This paper explores the concept of toy lending libraries. The first six chapters discuss: (1) the history of toy lending libraries; (2) the values and purposes of using games and toys with children; (2) the contribution of games and toys to the goals of a children's services library division; (3) examples of toy lending service in public…

  16. The Library Morphs

    ERIC Educational Resources Information Center

    Waters, John K.

    2008-01-01

    As campus renovation projects go, the Ohio State University's plan to turn its main library into "a library for the 21st century" is ambitious. The author describes the decade-long, $109 million transformation of the William Oxley Thompson Memorial Library. The overhaul calls for a complete replacement of all mechanical and electrical systems,…

  17. A Truly Bookless Library

    ERIC Educational Resources Information Center

    Kolowich, Steve

    2011-01-01

    The difference between the University of Texas at San Antonio's Applied Engineering and Technology Library and other science-focused libraries is not that its on-site collection is also available electronically. It is that its on-site collection is only available electronically. The idea of libraries with no bound books has been a recurring theme…

  18. Simple Library Bookkeeping.

    ERIC Educational Resources Information Center

    Hoffman, Herbert H.

    A simple and cheap manual double entry continuous transaction posting system with running balances is developed for bookkeeping by small libraries. A very small library may operate without any system of fiscal control but when a library's budget approaches three figures, some kind of bookkeeping must be introduced. To maintain control over his…

  19. Library Awareness Survey.

    ERIC Educational Resources Information Center

    Rice, James

    1992-01-01

    Reports results of a survey of Iowa City residents regarding their awareness of public library services. Data are presented on use of the library for factual information, statistical/numerical information, learning, and information not available at home; awareness of in-person and telephone library reference services; and knowledge about…

  20. PAL: Positional Astronomy Library

    NASA Astrophysics Data System (ADS)

    Jenness, T.; Berry, D. S.

    2016-06-01

    The PAL library is a partial re-implementation of Pat Wallace's popular SLALIB library written in C using a Gnu GPL license and layered on top of the IAU's SOFA library (or the BSD-licensed ERFA) where appropriate. PAL attempts to stick to the SLA C API where possible.

  1. Environmental Library Systems

    ERIC Educational Resources Information Center

    Thomas, Sarah M.; Needle, Lester P.

    1975-01-01

    The U. S. Environmental Protection Agency (EPA) Library System consists of 28 libraries. The libraries are supported by computer systems covering journal and book holdings, journal check-in, circulation, document control, EPA reports, international exchange items, and specialized subject area collections. (Author)

  2. Worthington Libraries, OH

    ERIC Educational Resources Information Center

    Berry, John N., III

    2007-01-01

    Worthington, Ohio, has deep library roots. A library has been part of its history since the planning by settlers before the city's birth in 1803. Among the treasures brought by James Kilbourne and the Scioto Company from Connecticut to the new, planned community they built was a collection of books for their new subscription library. The books…

  3. Staffing the College Library

    ERIC Educational Resources Information Center

    Thomas, Bruce

    1973-01-01

    College libraries use a variety of methods to identify and select professional library personnel. 70 libraries responded to a questionnaire about their methods and the results are presented. The effectiveness of advertisements, employment services, testing and reference checks are among the topics discussed. (DH)

  4. Merchandising Your Library.

    ERIC Educational Resources Information Center

    Sivulich, Kenneth G.

    1989-01-01

    Discusses library circulation figures as a reflection of the success of library services and describes merchandising techniques that have produced a 137 percent circulation increase at Queens Borough Public Library over the past seven years. Merchandising techniques such as minibranches, displays, signage, dumps, and modified shelving are…

  5. Libraries and the Environment.

    ERIC Educational Resources Information Center

    LaRue, James; And Others

    1991-01-01

    Three articles address issues that relate to libraries and the environment. Highlights include recycling projects; buying recycled paper products and other ecology-minded purchasing ideas; energy-efficient libraries; indoor pollution problems; a list of environmental information sources; designing library buildings; and activities that libraries…

  6. The Honor System Library

    ERIC Educational Resources Information Center

    Marie, Kristen L.

    2005-01-01

    An honor system library can be created inside the library media center (LMC). Where students can access free books and magazines that require no formal checkouts. The honor library system at Washington High School, Fremont, California, has become self-sustaining. As many students, parents and teachers donate quality material. No student is ever…

  7. School Libraries and Innovation

    ERIC Educational Resources Information Center

    McGrath, Kevin G.

    2015-01-01

    School library programs have measured success by improved test scores. But how do next-generation school libraries demonstrate success as they strive to be centers of innovation and creativity? These libraries offer solutions for school leaders who struggle to restructure existing systems built around traditional silos of learning (subjects and…

  8. Changing State Digital Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2006-01-01

    Research has shown that state virtual or digital libraries are evolving into websites that are loaded with free resources, subscription databases, and instructional tools. In this article, the author explores these evolving libraries based on the following questions: (1) How user-friendly are the state digital libraries?; (2) How do state digital…

  9. The Michigan Electronic Library.

    ERIC Educational Resources Information Center

    Davidsen, Susanna L.

    1997-01-01

    Describes the Michigan Electronic Library (MEL), the largest evaluated and organized Web-based library of Internet resources, that was designed to provide a library of electronic information resources selected by librarians. MEL's partnership is explained, the collection is described, and future developments are considered. (LRW)

  10. Summer Library Reading Programs

    ERIC Educational Resources Information Center

    Fiore, Carole D.

    2007-01-01

    Virtually all public libraries in the United States provide some type of summer library reading program during the traditional summer vacation period. Summer library reading programs provide opportunities for students of many ages and abilities to practice their reading skills and maintain skills that are developed during the school year. Fiore…

  11. Spanish Museum Libraries Network.

    ERIC Educational Resources Information Center

    Lopez de Prado, Rosario

    This paper describes the creation of an automated network of museum libraries in Spain. The only way in which the specialized libraries in the world today can continue to be active and to offer valid information is to automate the service they offer, and create network libraries with cooperative plans. The network can be configured with different…

  12. International School Library Day.

    ERIC Educational Resources Information Center

    Clyde, Laurel A.

    2001-01-01

    Describes the development of an International School Library Day and discusses activities in Australian school libraries. Highlights include the development of Web pages; sponsorship by national, state, or provincial associations; publicity materials; joint activities with other countries; student involvement; and activities with public libraries.…

  13. Technostress and Library Values.

    ERIC Educational Resources Information Center

    Gorman, Michael

    2001-01-01

    Discusses information overload and society's and libraries' responses to technology. Considers eight values that libraries should focus on and how they relate to technology in libraries: democracy, stewardship, service, intellectual freedom, privacy, rationalism, equity of access, and building harmony and balance. (LRW)

  14. Supervision in Libraries.

    ERIC Educational Resources Information Center

    Bailey, Martha J.

    Although the literature of library administration draws extensively on that of business management, it is difficult to compare library supervision to business or industrial supervision. Library supervisors often do not have managerial training and may consider their management role as secondary. The educational level of the staff they supervise…

  15. Public Libraries Going Green

    ERIC Educational Resources Information Center

    Miller, Kathryn

    2010-01-01

    Going green is now a national issue, and patrons expect their library to respond in the same way many corporations have. Libraries are going green with logos on their Web sites, programs for the public, and a host of other initiatives. This is the first book to focus strictly on the library's role in going green, helping you with: (1) Collection…

  16. Automation in Libraries.

    ERIC Educational Resources Information Center

    Canadian Library Association, Ottawa (Ontario).

    The fourth Canadian Association of College and University Libraries (CACUL) Conference on Library Automation was held in Hamilton, June 20-21, 1970, as a pre-conference workshop of the Canadian Library Association (CLA). The purpose of the conference was to present papers on current projects and to discuss the continuing need for this type of…

  17. Libraries in Africa.

    ERIC Educational Resources Information Center

    Enyia, Christian O.; And Others

    1991-01-01

    Includes five articles that discuss library and information work in Africa. Highlights include computerization in Nigerian libraries; education for library and information services in Ghana; an evaluation of African librarianship; the role of Nigerian publishers in national development; and the role of information services in national development…

  18. Rolled-Up Nanotech: Illumination-Controlled Hydrofluoric Acid Etching of AlAs Sacrificial Layers

    NASA Astrophysics Data System (ADS)

    Costescu, Ruxandra M.; Deneke, Christoph; Thurmer, Dominic J.; Schmidt, Oliver G.

    2009-12-01

    The effect of illumination on the hydrofluoric acid etching of AlAs sacrificial layers with systematically varied thicknesses in order to release and roll up InGaAs/GaAs bilayers was studied. For thicknesses of AlAs below 10 nm, there were two etching regimes for the area under illumination: one at low illumination intensities, in which the etching and releasing proceeds as expected and one at higher intensities in which the etching and any releasing are completely suppressed. The “etch suppression” area is well defined by the illumination spot, a feature that can be used to create heterogeneously etched regions with a high degree of control, shown here on patterned samples. Together with the studied self-limitation effect, the technique offers a way to determine the position of rolled-up micro- and nanotubes independently from the predefined lithographic pattern.

  19. Photodynamic therapy (ALA-PDT) in the treatment of pathological states of the cornea

    NASA Astrophysics Data System (ADS)

    Switka-Wieclawska, Iwona; Kecik, Tadeusz; Kwasny, Miroslaw; Graczyk, Alfreda

    2003-10-01

    Each year an increasing amount of research is published on the use of photodynamic therapy in medicine. The most recent research has focused mostly on the use of photosensitizer called vertoporphyrin (Visudyne) is the treatment of subretinal neovascularization in age-related macular degeneration (AMD) or myopia, following a substantial amount of ophthalmology research mostly experimental on the application of the method in diagnosis and treatment of some eye tumors. In the Department of Ophthalmology of Polish Medical University in Warsaw, PDT was used as supplementary method in a selected group of patients with chronic virus ulcer of the cornea and keratopathies. During the treatment 5-aminolevulinic acid (5-ALA) was applied in ointment form as a photosensitizer activated with light wave of 633 nm. It appears, on the basis of the results obtained, that photodynamic therapy (ALA-PDT) may become in the future a valuable supplement to the methods being used at the present treating pathological states of the cornea.

  20. Photodynamic diagnosis following intravesical instillation of aminolevulinic acid (ALA): first clinical experiences in urology

    NASA Astrophysics Data System (ADS)

    Baumgartner, Reinhold; Kriegmair, M.; Stepp, Herbert G.; Lumper, W.; Heil, Peter; Riesenberg, Rainer; Stocker, Susanne; Hofstetter, Alfons G.

    1993-06-01

    Delta Aminolevulinic acid (ALA), a precursor of Protoporphyrin IX (PP IX) in hem biosynthesis has been topically applied in urinary bladders in order to study its potential as fluorescent tumor marker. Preclinical experiments have been performed on chemically induced tumors in rats, revealing a ratio of PP IX-fluorescence intensity up to 20:1 in tumors as compared to healthy urothelium. Synthesis of PP IX has been stimulated in 56 patients by intravesical instillation of a pH-neutral ALA-solution. After an incubation time of two to four hours strong red fluorescence was endoscopically observed even in tiny superficial tumors. Brightness and contrast allows visualization of early stage urothelial diseases with naked eyes and without the necessity suppressing background fluorescence or violet excitation light.