Sample records for alaska special regulations-gates

  1. Defense.gov - Special Report - Travels With Gates

    Science.gov Websites

    /Photos Leaders DoD Web Sites Contact Us Shangri-La Dialogue: Asia Security Summit Alaska Visit – June Shangri-La Dialogue on Asia Security Summit, Singapore, May 30, 2009. DoD photo by U.S. Air Force Master Robert M. Gates opened the “Shangri-La Dialogue” Asia security summit outlining broad security issues

  2. 45 CFR 2532.20 - Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska. 2532.20 Section 2532.20 Public Welfare Regulations Relating to Public Welfare..., developed in cooperation with the Yupi'k speaking population that resides in such communities, for...

  3. 45 CFR 2532.20 - Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska. 2532.20 Section 2532.20 Public Welfare Regulations Relating to Public Welfare..., developed in cooperation with the Yupi'k speaking population that resides in such communities, for...

  4. 45 CFR 2532.20 - Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska. 2532.20 Section 2532.20 Public Welfare Regulations Relating to Public Welfare..., developed in cooperation with the Yupi'k speaking population that resides in such communities, for...

  5. 45 CFR 2532.20 - Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska. 2532.20 Section 2532.20 Public Welfare Regulations Relating to Public Welfare..., developed in cooperation with the Yupi'k speaking population that resides in such communities, for...

  6. 45 CFR 2532.20 - Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Special Demonstration Project for the Yukon-Kuskokwim Delta of Alaska. 2532.20 Section 2532.20 Public Welfare Regulations Relating to Public Welfare..., developed in cooperation with the Yupi'k speaking population that resides in such communities, for...

  7. 36 CFR 13.1002 - Subsistence resident zone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and... resident zone for Gates of the Arctic National Park: Alatna, Allakaket, Ambler, Anaktuvuk Pass, Bettles...

  8. 36 CFR 13.1002 - Subsistence resident zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and... resident zone for Gates of the Arctic National Park: Alatna, Allakaket, Ambler, Anaktuvuk Pass, Bettles...

  9. Alaska Special Education Recruitment and Retention Resource Manual.

    ERIC Educational Resources Information Center

    Schnorr, Janice M.; Brady, Nancy J.

    This resource manual is designed to assist Alaska school districts in recruiting and retaining special education teachers. It offers 50 practical suggestions for developing an effective recruitment program, focusing on the processes of gathering information; developing recruiters, materials, and strategies; and screening and interviewing…

  10. Defense.gov - Special Report - Travels With Gates

    Science.gov Websites

    ., Poland Sign Special Ops Memo of Understanding KRAKOW, Poland, Feb. 19, 2009 – Defense Secretary Robert M . Gates and Polish Defense Minister Bogdan Klich signed a memorandum of understanding that will increase

  11. 36 CFR 13.1006 - Customary trade.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve § 13.1006 Customary trade. In the Gates of the Arctic National Preserve unit which contains the Kobuk...

  12. 36 CFR 13.1006 - Customary trade.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve § 13.1006 Customary trade. In the Gates of the Arctic National Preserve unit which contains the Kobuk...

  13. 30 CFR 716.6 - Coal mines in Alaska.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Coal mines in Alaska. 716.6 Section 716.6... PROGRAM REGULATIONS SPECIAL PERFORMANCE STANDARDS § 716.6 Coal mines in Alaska. (a) Permittees of surface coal mining operations in Alaska from which coal has been mined on or after August 3, 1977, shall...

  14. 30 CFR 716.6 - Coal mines in Alaska.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Coal mines in Alaska. 716.6 Section 716.6... PROGRAM REGULATIONS SPECIAL PERFORMANCE STANDARDS § 716.6 Coal mines in Alaska. (a) Permittees of surface coal mining operations in Alaska from which coal has been mined on or after August 3, 1977, shall...

  15. 30 CFR 716.6 - Coal mines in Alaska.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Coal mines in Alaska. 716.6 Section 716.6... PROGRAM REGULATIONS SPECIAL PERFORMANCE STANDARDS § 716.6 Coal mines in Alaska. (a) Permittees of surface coal mining operations in Alaska from which coal has been mined on or after August 3, 1977, shall...

  16. 30 CFR 716.6 - Coal mines in Alaska.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Coal mines in Alaska. 716.6 Section 716.6... PROGRAM REGULATIONS SPECIAL PERFORMANCE STANDARDS § 716.6 Coal mines in Alaska. (a) Permittees of surface coal mining operations in Alaska from which coal has been mined on or after August 3, 1977, shall...

  17. 30 CFR 716.6 - Coal mines in Alaska.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Coal mines in Alaska. 716.6 Section 716.6... PROGRAM REGULATIONS SPECIAL PERFORMANCE STANDARDS § 716.6 Coal mines in Alaska. (a) Permittees of surface coal mining operations in Alaska from which coal has been mined on or after August 3, 1977, shall...

  18. Redox regulation of neuronal voltage-gated calcium channels.

    PubMed

    Todorovic, Slobodan M; Jevtovic-Todorovic, Vesna

    2014-08-20

    Voltage-gated calcium channels are ubiquitously expressed in neurons and are key regulators of cellular excitability and synaptic transmitter release. There is accumulating evidence that multiple subtypes of voltage-gated calcium channels may be regulated by oxidation and reduction. However, the redox mechanisms involved in the regulation of channel function are not well understood. Several studies have established that both T-type and high-voltage-activated subtypes of voltage-gated calcium channel can be redox-regulated. This article reviews different mechanisms that can be involved in redox regulation of calcium channel function and their implication in neuronal function, particularly in pain pathways and thalamic oscillation. A current critical issue in the field is to decipher precise mechanisms of calcium channel modulation via redox reactions. In this review we discuss covalent post-translational modification via oxidation of cysteine molecules and chelation of trace metals, and reactions involving nitric oxide-related molecules and free radicals. Improved understanding of the roles of redox-based reactions in regulation of voltage-gated calcium channels may lead to improved understanding of novel redox mechanisms in physiological and pathological processes. Identification of redox mechanisms and sites on voltage-gated calcium channel may allow development of novel and specific ion channel therapies for unmet medical needs. Thus, it may be possible to regulate the redox state of these channels in treatment of pathological process such as epilepsy and neuropathic pain.

  19. Redox Regulation of Neuronal Voltage-Gated Calcium Channels

    PubMed Central

    Jevtovic-Todorovic, Vesna

    2014-01-01

    Abstract Significance: Voltage-gated calcium channels are ubiquitously expressed in neurons and are key regulators of cellular excitability and synaptic transmitter release. There is accumulating evidence that multiple subtypes of voltage-gated calcium channels may be regulated by oxidation and reduction. However, the redox mechanisms involved in the regulation of channel function are not well understood. Recent Advances: Several studies have established that both T-type and high-voltage-activated subtypes of voltage-gated calcium channel can be redox-regulated. This article reviews different mechanisms that can be involved in redox regulation of calcium channel function and their implication in neuronal function, particularly in pain pathways and thalamic oscillation. Critical Issues: A current critical issue in the field is to decipher precise mechanisms of calcium channel modulation via redox reactions. In this review we discuss covalent post-translational modification via oxidation of cysteine molecules and chelation of trace metals, and reactions involving nitric oxide-related molecules and free radicals. Improved understanding of the roles of redox-based reactions in regulation of voltage-gated calcium channels may lead to improved understanding of novel redox mechanisms in physiological and pathological processes. Future Directions: Identification of redox mechanisms and sites on voltage-gated calcium channel may allow development of novel and specific ion channel therapies for unmet medical needs. Thus, it may be possible to regulate the redox state of these channels in treatment of pathological process such as epilepsy and neuropathic pain. Antioxid. Redox Signal. 21, 880–891. PMID:24161125

  20. 75 FR 3888 - Migratory Bird Subsistence Harvest in Alaska; Harvest Regulations for Migratory Birds in Alaska...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ...-0082; 91200-1231-9BPP-L2] RIN 1018-AW67 Migratory Bird Subsistence Harvest in Alaska; Harvest Regulations for Migratory Birds in Alaska During the 2010 Season AGENCY: Fish and Wildlife Service, Interior... Service, are reopening the public comment period on our proposed rule to establish migratory bird...

  1. Improving pH sensitivity by field-induced charge regulation in flexible biopolymer electrolyte gated oxide transistors

    NASA Astrophysics Data System (ADS)

    Liu, Ning; Gan, Lu; Liu, Yu; Gui, Weijun; Li, Wei; Zhang, Xiaohang

    2017-10-01

    Electrical manipulation of charged ions in electrolyte-gated transistors is crucial for enhancing the electric-double-layer (EDL) gating effect, thereby improving their sensing abilities. Here, indium-zinc-oxide (IZO) based thin-film-transistors (TFTs) are fabricated on flexible plastic substrate. Acid doped chitosan-based biopolymer electrolyte is used as the gate dielectric, exhibiting an extremely high EDL capacitance. By regulating the dynamic EDL charging process with special gate potential profiles, the EDL gating effect of the chitosan-gated TFT is enhanced, and then resulting in higher pH sensitivities. An extremely high sensitivity of ∼57.8 mV/pH close to Nernst limit is achieved when the gate bias of the TFT sensor sweeps at a rate of 10 mV/s. Additionally, an enhanced sensitivity of 2630% in terms of current variation with pH range from 11 to 3 is realized when the device is operated in the ion depletion mode with a negative gate bias of -0.7 V. Robust ionic modulation is demonstrated in such chitosan-gated sensors. Efficiently driving the charged ions in the chitosan-gated IZO-TFT provides a new route for ultrasensitive, low voltage, and low-cost biochemical sensing technologies.

  2. 36 CFR 13.1002 - Subsistence resident zone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....1002 Section 13.1002 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and... resident zone for Gates of the Arctic National Park: Alatna, Allakaket, Ambler, Anaktuvuk Pass, Bettles...

  3. A Special Report on the Alaska Commission on Postsecondary Education--Collection of Defaulted Student Loans.

    ERIC Educational Resources Information Center

    Welker, Randy S.

    In accordance with a Legislative Budget and Audit Committee special request and the provisions of Title 24 of the Alaska Statutes, a review was conducted of the Alaska Commission on Postsecondary Education's experience with various collection contractors used to collect defaulted student loans. The primary purpose was to assess the success that…

  4. Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate

    NASA Astrophysics Data System (ADS)

    Schultz, Daniel; Lu, Mingyang; Stavropoulos, Trevor; Onuchic, Jose'; Ben-Jacob, Eshel

    2013-04-01

    Sporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities - each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters.

  5. Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate

    PubMed Central

    Schultz, Daniel; Lu, Mingyang; Stavropoulos, Trevor; Onuchic, Jose'; Ben-Jacob, Eshel

    2013-01-01

    Sporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities – each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters. PMID:23591544

  6. 76 FR 17353 - Migratory Bird Subsistence Harvest in Alaska; Harvest Regulations for Migratory Birds in Alaska...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... proposed rule and further internal discussions, the Service is removing the shooting hours restriction... Service, working with partners, developed measures in 2009 to further reduce the potential for shooting... shooting hours restriction, this regulation is similar to one in the State of Alaska's fall regulations...

  7. 33 CFR 165.1704 - Prince William Sound, Alaska-regulated navigation area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Prince William Sound, Alaska... District § 165.1704 Prince William Sound, Alaska-regulated navigation area. (a) The following is a... Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between 146°30′ W...

  8. 33 CFR 165.1704 - Prince William Sound, Alaska-regulated navigation area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Prince William Sound, Alaska... District § 165.1704 Prince William Sound, Alaska-regulated navigation area. (a) The following is a... Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between 146°30′ W...

  9. 33 CFR 165.1704 - Prince William Sound, Alaska-regulated navigation area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Prince William Sound, Alaska... District § 165.1704 Prince William Sound, Alaska-regulated navigation area. (a) The following is a... Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between 146°30′ W...

  10. 33 CFR 165.1704 - Prince William Sound, Alaska-regulated navigation area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Prince William Sound, Alaska... District § 165.1704 Prince William Sound, Alaska-regulated navigation area. (a) The following is a... Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between 146°30′ W...

  11. 33 CFR 165.1704 - Prince William Sound, Alaska-regulated navigation area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Prince William Sound, Alaska... District § 165.1704 Prince William Sound, Alaska-regulated navigation area. (a) The following is a... Hinchinbrook Light to Schooner Rock Light, comprising that portion of Prince William Sound between 146°30′ W...

  12. 36 CFR 13.1006 - Customary trade.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Customary trade. 13.1006 Section 13.1006 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve § 13.1006 Customary trade. In the Gates of the...

  13. 36 CFR 13.1006 - Customary trade.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Customary trade. 13.1006 Section 13.1006 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve § 13.1006 Customary trade. In the Gates of the...

  14. 36 CFR 36.19 - Special actions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Special actions. 36.19... MANAGEMENT REGULATIONS FOR PUBLIC LANDS IN ALASKA Program Structure § 36.19 Special actions. (a) Emergency special actions. In an emergency situation, if necessary to ensure the continued viability of a fish or...

  15. Amchitka Island, Alaska, special sampling project 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    U.S. Department of Energy, Nevada Operations Office

    2000-06-28

    This 1997 special sampling project represents a special radiobiological sampling effort to augment the 1996 Long-Term Hydrological Monitoring Program (LTHMP) for Amchitka Island in Alaska. Lying in the western portion of the Aleutian Islands arc, near the International Date Line, Amchitka Island is one of the southernmost islands of the Rat Island Chain. Between 1965 and 1971, the U.S. Atomic Energy Commission conducted three underground nuclear tests on Amchitka Island. In 1996, Greenpeace collected biota samples and speculated that several long-lived, man-made radionuclides detected (i.e., americium-241, plutonium-239 and -240, beryllium-7, and cesium-137) leaked into the surface environment from underground cavitiesmore » created during the testing. The nuclides of interest are detected at extremely low concentrations throughout the environment. The objectives of this special sampling project were to scientifically refute the Greenpeace conclusions that the underground cavities were leaking contaminants to the surface. This was achieved by first confirming the presence of these radionuclides in the Amchitka Island surface environment and, second, if the radionuclides were present, determining if the source is the underground cavity or worldwide fallout. This special sampling and analysis determined that the only nonfallout-related radionuclide detected was a low level of tritium from the Long Shot test, which had been previously documented. The tritium contamination is monitored and continues a decreasing trend due to radioactive decay and dilution.« less

  16. 24 CFR 598.515 - Alaska and Hawaii.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Alaska and Hawaii. 598.515 Section 598.515 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Special Rules § 598...

  17. 24 CFR 598.515 - Alaska and Hawaii.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Alaska and Hawaii. 598.515 Section 598.515 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Special Rules § 598...

  18. 24 CFR 598.515 - Alaska and Hawaii.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Alaska and Hawaii. 598.515 Section 598.515 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Special Rules § 598...

  19. 24 CFR 598.515 - Alaska and Hawaii.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Alaska and Hawaii. 598.515 Section 598.515 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES URBAN EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Special Rules § 598...

  20. 36 CFR 13.1004 - Aircraft use.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Aircraft use. 13.1004 Section 13.1004 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve...

  1. 36 CFR 13.1004 - Aircraft use.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Aircraft use. 13.1004 Section 13.1004 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve...

  2. 36 CFR 13.1006 - Customary trade.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Customary trade. 13.1006 Section 13.1006 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve...

  3. 36 CFR 13.1008 - Solid waste disposal.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 13.1008 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve § 13.1008 Solid waste disposal. (a) A solid waste disposal site may accept non-National Park Service...

  4. 36 CFR 13.1004 - Aircraft use.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Aircraft use. 13.1004 Section 13.1004 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Gates of the Arctic National Park and Preserve...

  5. Sterol Regulation of Voltage-Gated K+ Channels.

    PubMed

    Balajthy, Andras; Hajdu, Peter; Panyi, Gyorgy; Varga, Zoltan

    2017-01-01

    Cholesterol is an essential lipid building block of the cellular plasma membrane. In addition to its structural role, it regulates the fluidity and raft structure of the membrane and influences the course of numerous membrane-linked signaling pathways and the function of transmembrane proteins, including ion channels. This is supported by a vast body of scientific data, which demonstrates the modulation of ion channels with a great variety of ion selectivity, gating, and tissue distribution by changes in membrane cholesterol. Here, we review what is currently known about the modulation of voltage-gated K + (Kv) channels by changes in membrane cholesterol content, considering raft association of the channels, the roles of cholesterol recognition sites, and those of adaptor proteins in cholesterol-Kv channel interactions. We specifically focus on Kv1.3, the dominant K + channel of human T cells. Effects of cholesterol depletion and enrichment and 7-dehydrocholesterol enrichment on Kv1.3 gating are discussed in the context of the immunological synapse and the comparison of the in vitro effects of sterol modifications on Kv1.3 function with ex vivo effects on cells from hypercholesterolemic and Smith-Lemli-Opitz patients. © 2017 Elsevier Inc. All rights reserved.

  6. 102. Giullotine type gate (inclosed position to regulate furnace exhaust ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    102. Giullotine type gate (inclosed position to regulate furnace exhaust gases to stoves during heating cycle. - Sloss-Sheffield Steel & Iron, First Avenue North Viaduct at Thirty-second Street, Birmingham, Jefferson County, AL

  7. 50 CFR 26.33 - Special regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Special regulations. 26.33 Section 26.33... NATIONAL WILDLIFE REFUGE SYSTEM PUBLIC ENTRY AND USE Public Use and Recreation § 26.33 Special regulations. (a) Special regulations shall be issued for public use, access, and recreation within certain...

  8. 50 CFR 26.33 - Special regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Special regulations. 26.33 Section 26.33... NATIONAL WILDLIFE REFUGE SYSTEM PUBLIC ENTRY AND USE Public Use and Recreation § 26.33 Special regulations. (a) Special regulations shall be issued for public use, access, and recreation within certain...

  9. Defense.gov - Special Report - Travels With Gates

    Science.gov Websites

    . Defense Secretary Robert M. Gates re-enlists soldiers deployed on Field Operating Base Airborne in the province of Kandahar. Story» Gates Develops 'To Do' List From Two-Day Afghan Visit FORWARD OPERATING BASE momentum. Story» Gates Assures 10th Mountain Soldiers of Continued Support FORWARD OPERATING BASE AIRBORNE

  10. Defense.gov - Special Report - Travels With Gates

    Science.gov Websites

    , Jordan, July 27, 2009 – The United States and Jordan enjoy a strategic partnership aimed at promoting peace in the greater Middle East, Defense Secretary Robert M. Gates said here today. Story Gates – Defense Secretary Robert M. Gates is on a trip to the Middle East with stops in Israel and Jordan.Story

  11. 76 FR 7518 - Outer Continental Shelf Air Regulations Consistency Update for Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 55 [EPA-R10-OAR-2011-0045; FRL-9265-3] Outer Continental Shelf Air Regulations Consistency Update for Alaska AGENCY: Environmental Protection Agency (``EPA... Greaves, Federal and Delegated Air Programs Unit, U.S. Environmental Protection Agency, Region 10, 1200...

  12. DefenseLink Special: Travels with Gates, January 2007

    Science.gov Websites

    that has been achieved there, said Defense Secretary Robert M. Gates. Story Gates to Build on Success , and Defense Secretary Robert M. Gates wants to build on those successes. Story Afghan Army Makes

  13. 33 CFR 100.35 - Special local regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Special local regulations. 100.35... MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.35 Special local regulations. (a) The Commander... authorized to promulgate such special local regulations as he or she deems necessary to insure safety of life...

  14. 36 CFR 7.97 - Golden Gate National Recreation Area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.97 Golden Gate National... Alcatraz Island. (b) Powerless flight. The use of devices designed to carry persons through the air in..., sidewalks and grass lawn of the former Coast Guard Station complex) that stretches east from the Torpedo...

  15. Defense.gov - Special Report - Travels With Gates

    Science.gov Websites

    , Defense Secretary Robert M. Gates said. Story Gates Touts F-35 as Heart Of Future Combat Aviation FORT Lightning II Joint Strike Fighter factory, assessing progress on what he called “the heart of the future of

  16. DefenseLink.mil - Special Report - Travels With Gates

    Science.gov Websites

    of Estonia Estonia Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates walks with the Prime Minister of Estonia Andrus

  17. 43 CFR 2091.9 - Segregation and opening resulting from laws specific to Alaska.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Segregation and opening resulting from laws specific to Alaska. 2091.9 Section 2091.9 Public Lands: Interior Regulations Relating to Public...) SPECIAL LAWS AND RULES Segregation and Opening of Lands § 2091.9 Segregation and opening resulting from...

  18. Calmodulin regulates Cav3 T-type channels at their gating brake

    PubMed Central

    Taiakina, Valentina; Monteil, Arnaud; Piazza, Michael; Guan, Wendy; Stephens, Robert F.; Dieckmann, Thorsten; Guillemette, Joseph Guy; Spafford, J. David

    2017-01-01

    Calcium (Cav1 and Cav2) and sodium channels possess homologous CaM-binding motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a universal calcium sensor. Cav3 T-type channels, which serve as pacemakers of the mammalian brain and heart, lack a C-terminal IQ motif. We illustrate that T-type channels associate with CaM using co-immunoprecipitation experiments and single particle cryo-electron microscopy. We demonstrate that protostome invertebrate (LCav3) and human Cav3.1, Cav3.2, and Cav3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I–II linker of the channels. Isothermal titration calorimetry results revealed that the gating brake and CaM bind each other with high-nanomolar affinity. We show that the gating brake assumes a helical conformation upon binding CaM, with associated conformational changes to both CaM lobes as indicated by amide chemical shifts of the amino acids of CaM in 1H-15N HSQC NMR spectra. Intact Ca2+-binding sites on CaM and an intact gating brake sequence (first 39 amino acids of the I–II linker) were required in Cav3.2 channels to prevent the runaway gating phenotype, a hyperpolarizing shift in voltage sensitivities and faster gating kinetics. We conclude that the presence of high-nanomolar affinity binding sites for CaM at its universal gating brake and its unique form of regulation via the tuning of the voltage range of activity could influence the participation of Cav3 T-type channels in heart and brain rhythms. Our findings may have implications for arrhythmia disorders arising from mutations in the gating brake or CaM. PMID:28972185

  19. Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.

    PubMed

    Ehrhardt, Annette; Chung, W Joon; Pyle, Louise C; Wang, Wei; Nowotarski, Krzysztof; Mulvihill, Cory M; Ramjeesingh, Mohabir; Hong, Jeong; Velu, Sadanandan E; Lewis, Hal A; Atwell, Shane; Aller, Steve; Bear, Christine E; Lukacs, Gergely L; Kirk, Kevin L; Sorscher, Eric J

    2016-01-22

    In this study, we present data indicating a robust and specific domain interaction between the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loop (CL1) and nucleotide binding domain 1 (NBD1) that allows ion transport to proceed in a regulated fashion. We used co-precipitation and ELISA to establish the molecular contact and showed that binding kinetics were not altered by the common clinical mutation F508del. Both intrinsic ATPase activity and CFTR channel gating were inhibited severely by CL1 peptide, suggesting that NBD1/CL1 binding is a crucial requirement for ATP hydrolysis and channel function. In addition to cystic fibrosis, CFTR dysregulation has been implicated in the pathogenesis of prevalent diseases such as chronic obstructive pulmonary disease, acquired rhinosinusitis, pancreatitis, and lethal secretory diarrhea (e.g. cholera). On the basis of clinical relevance of the CFTR as a therapeutic target, a cell-free drug screen was established to identify modulators of NBD1/CL1 channel activity independent of F508del CFTR and pharmacologic rescue. Our findings support a targetable mechanism of CFTR regulation in which conformational changes in the NBDs cause reorientation of transmembrane domains via interactions with CL1 and result in channel gating. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  20. 78 FR 14589 - Notice of Open Public Meetings for the National Park Service (NPS) Alaska Region's Subsistence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... NPS is hereby giving notice that the Gates of the Arctic National Park Subsistence Resource Commission... 808 of the Alaska National Interest Lands Conservation Act, Public Law 96-487. Gates of the Arctic National Park SRC Meeting Date and Location: The Gates of the Arctic National Park SRC will meet from 9:00...

  1. Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?

    PubMed

    Niemeyer, María Isabel; Cid, L Pablo; González, Wendy; Sepúlveda, Francisco V

    2016-09-01

    K2P K(+) channels with two pore domains in tandem associate as dimers to produce so-called background conductances that are regulated by a variety of stimuli. Whereas gating in K2P channels has been poorly understood, recent developments have provided important clues regarding the gating mechanism for this family of proteins. Two modes of gating present in other K(+) channels have been considered. The first is the so-called activation gating that occurs by bundle crossing and the splaying apart of pore-lining helices commanding ion passage. The second mode involves a change in conformation at the selectivity filter (SF), which impedes ion flow at this narrow portion of the conduction pathway and accounts for extracellular pH modulation of several K2P channels. Although some evidence supports the existence of an activation gate in K2P channels, recent results suggest that perhaps all stimuli, even those sensed at a distant location in the protein, are also mediated by SF gating. Recently resolved crystal structures of K2P channels in conductive and nonconductive conformations revealed that the nonconductive state is reached by blockade by a lipid acyl chain that gains access to the channel cavity through intramembrane fenestrations. Here we discuss whether this novel type of gating, proposed so far only for membrane tension gating, might mediate gating in response to other stimuli or whether SF gating is the only type of opening/closing mechanism present in K2P channels. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  2. TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels.

    PubMed

    Anderson, Evan O; Schneider, Eve R; Matson, Jon D; Gracheva, Elena O; Bagriantsev, Sviatoslav N

    2018-04-17

    Neuronal mechano-sensitivity relies on mechano-gated ion channels, but pathways regulating their activity remain poorly understood. TMEM150C was proposed to mediate mechano-activated current in proprioceptive neurons. Here, we studied functional interaction of TMEM150C with mechano-gated ion channels from different classes (Piezo2, Piezo1, and the potassium channel TREK-1) using two independent methods of mechanical stimulation. We found that TMEM150C significantly prolongs the duration of the mechano-current produced by all three channels, decreases apparent activation threshold in Piezo2, and induces persistent current in Piezo1. We also show that TMEM150C is co-expressed with Piezo2 in trigeminal neurons, expanding its role beyond proprioceptors. Finally, we cloned TMEM150C from the trigeminal neurons of the tactile-foraging domestic duck and showed that it functions similarly to the mouse ortholog, demonstrating evolutionary conservation among vertebrates. Our studies reveal TMEM150C as a general regulator of mechano-gated ion channels from different classes. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

  3. 78 FR 11988 - Migratory Bird Subsistence Harvest in Alaska; Harvest Regulations for Migratory Birds in Alaska...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ...-management process involving the Service, the Alaska Department of Fish and Game, and Alaska Native... developed under a co-management process involving the Service, the Alaska Department of Fish and Game, and... Fish and Game's request to expand the Fairbanks North Star Borough excluded area to include the Central...

  4. DefenseLink Special: Stryker Brigade Returns to Fort Wainwright, Alaska

    Science.gov Websites

    Fort Wainwright, Alaska, Dec. 13, 2006. Defense Dept. photo by William D. Moss More Photos Leaders command ceremony in Fairbanks, Alaska, Dec. 14, 2006. Defense Dept. photo by William D. Moss More Photos

  5. Winter wolf predation in a multiple ungulate prey system, Gates of the Arctic National Park, Alaska

    USGS Publications Warehouse

    Dale, Bruce W.; Adams, Layne G.; Bowyer, R. Terry; Carbyn, Ludwig N.; Fritts, Steven H.; Seip, Dale R.

    1995-01-01

    We investigated patterns of winter wolf predation, including prey selection, prey switching, kill rates, carcass utilization, and consumption rates for four wolf packs during three different study periods (March 1989, March 1990, and November 1990) in Gates of the Arctic National Park and Preserve, Alaska. Wolves killed predominantly caribou (165 caribou, seven moose, and five Dall sheep) even when moose and sheep were more abundant. Prey selection varied between study periods. More moose were killed in march 1989, a particularly deep snow year, and more sheep were killed in November 1990 than during other periods. Overall kill rates ranged from 0-8 days/ungulate killed (x̅ = 2.0, SD = 1.6) and did not vary between study periods.  Pack size and species killed explained significant variation in the length of time intervals between kills. Although caribou density varied nearly 40-fold between pack territories, it had little influence on predation characteristics except at low densities, when kill rates may have declined. Caribou distribution had marked effects on wolf predation rate.

  6. Alaska Natives In Higher Education.

    ERIC Educational Resources Information Center

    Kohout, Karen; Kleinfeld, Judith

    This study examines changes in the entrance and success rates of Native students in Alaska colleges from 1963 to 1972, a time when special college recruitment and assistance programs were being developed. Information is based on the college records of those Natives who entered college for the first time at the University of Alaska at Fairbanks…

  7. Defense.gov Special Report: Travels with Gates - January 2011

    Science.gov Websites

    as the new chief of U.S. Strategic Command during a change-of-command ceremony held at Offutt Air well for real fiscal change, Defense Secretary Robert M. Gates said in Ottawa, Canada. Story Gates Essays Gates, Mullen Attend Change of Command Ceremony More Photo Essays Secretary Attends Meetings in

  8. Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains

    PubMed Central

    Garcia-Olivares, Jennie; Alekov, Alexi; Boroumand, Mohammad Reza; Begemann, Birgit; Hidalgo, Patricia; Fahlke, Christoph

    2008-01-01

    Eukaryotic ClC channels are dimeric proteins with each subunit forming an individual protopore. Single protopores are gated by a fast gate, whereas the slow gate is assumed to control both protopores through a cooperative movement of the two carboxy-terminal domains. We here study the role of the carboxy-terminal domain in modulating fast and slow gating of human ClC-2 channels, a ubiquitously expressed ClC-type chloride channel involved in transepithelial solute transport and in neuronal chloride homeostasis. Partial truncation of the carboxy-terminus abolishes function of ClC-2 by locking the channel in a closed position. However, unlike other isoforms, its complete removal preserves function of ClC-2. ClC-2 channels without the carboxy-terminus exhibit fast and slow gates that activate and deactivate significantly faster than in WT channels. In contrast to the prevalent view, a single carboxy-terminus suffices for normal slow gating, whereas both domains regulate fast gating of individual protopores. Our findings demonstrate that the carboxy-terminus is not strictly required for slow gating and that the cooperative gating resides in other regions of the channel protein. ClC-2 is expressed in neurons and believed to open at negative potentials and increased internal chloride concentrations after intense synaptic activity. We propose that the function of the ClC-2 carboxy-terminus is to slow down the time course of channel activation in order to stabilize neuronal excitability PMID:18801843

  9. Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains.

    PubMed

    Garcia-Olivares, Jennie; Alekov, Alexi; Boroumand, Mohammad Reza; Begemann, Birgit; Hidalgo, Patricia; Fahlke, Christoph

    2008-11-15

    Eukaryotic ClC channels are dimeric proteins with each subunit forming an individual protopore. Single protopores are gated by a fast gate, whereas the slow gate is assumed to control both protopores through a cooperative movement of the two carboxy-terminal domains. We here study the role of the carboxy-terminal domain in modulating fast and slow gating of human ClC-2 channels, a ubiquitously expressed ClC-type chloride channel involved in transepithelial solute transport and in neuronal chloride homeostasis. Partial truncation of the carboxy-terminus abolishes function of ClC-2 by locking the channel in a closed position. However, unlike other isoforms, its complete removal preserves function of ClC-2. ClC-2 channels without the carboxy-terminus exhibit fast and slow gates that activate and deactivate significantly faster than in WT channels. In contrast to the prevalent view, a single carboxy-terminus suffices for normal slow gating, whereas both domains regulate fast gating of individual protopores. Our findings demonstrate that the carboxy-terminus is not strictly required for slow gating and that the cooperative gating resides in other regions of the channel protein. ClC-2 is expressed in neurons and believed to open at negative potentials and increased internal chloride concentrations after intense synaptic activity. We propose that the function of the ClC-2 carboxy-terminus is to slow down the time course of channel activation in order to stabilize neuronal excitability.

  10. Radiometric age map of southcentral Alaska

    USGS Publications Warehouse

    Wilson, Frederic H.; Turner, D.L.

    1975-01-01

    This map includes published, thesis, and open-file radiometric data available to us as of June, 1975. Some dates are not plotted because of inadequate location data in the original references.The map is divided into five sections, based on 1:1,000,000 scale enlargements of the National Atlas maps of Alaska. Within each section (e.g., southeastern Alaska), radiometric dates are plotted and keyed to 1:250,000 scale quadrangles. Accompanying each map section is table 1, listing map numbers and the sample identification numbers used in DGGS Special Report 10: Radiometric Dates from Alaska-A 1975 Compilation”. The reader is referred to Special Report 10 for more complete information on location, rock type, dating method, and literature references for each age entry. A listing of dates in Special Report lo which require correction or deletion is included S table 2. Corrected and additional entries are listed in table 3. The listings in tables 2 and 3 follow the format of Special Report 10. Table 4 is a glossary of abbreviations used for quadrangle name, rock type, mineral dated, and type of dating method used.

  11. Radiometric age map of southwest Alaska

    USGS Publications Warehouse

    Wilson, Frederic H.; Turner, D.L.

    1975-01-01

    This map includes published, thesis, and open-file radiometric data available to us as of June, 1975. Some dates are not plotted because of inadequate location data in the original references.The map is divided into five sections, based on 1:1,000,000 scale enlargements of the National Atlas maps of Alaska. Within each section (e.g., southeastern Alaska), radiometric dates are plotted and keyed to 1:250,000 scale quadrangles. Accompanying each map section is table 1, listing map numbers and the sample identification numbers used in DGGS Special Report 10: Radiometric Dates from Alaska-A 1975 Compilation”. The reader is referred to Special Report 10 for more complete information on location, rock type, dating method, and literature references for each age entry. A listing of dates in Special Report lo which require correction or deletion is included S table 2. Corrected and additional entries are listed in table 3. The listings in tables 2 and 3 follow the format of Special Report 10. Table 4 is a glossary of abbreviations used for quadrangle name, rock type, mineral dated, and type of dating method used.

  12. Radiometric age map of southeast Alaska

    USGS Publications Warehouse

    Wilson, Frederic H.; Turner, D.L.

    1975-01-01

    This map includes published, thesis, and open-file radiometric data available to us as of June, 1975. Some dates are not plotted because of inadequate location data in the original references.The map is divided into five sections, based on 1:1,000,000 scale enlargements of the National Atlas maps of Alaska. Within each section (e.g., southeastern Alaska), radiometric dates are plotted and keyed to 1:250,000 scale quadrangles. Accompanying each map section is table 1, listing map numbers and the sample identification numbers used in DGGS Special Report 10: Radiometric Dates from Alaska-A 1975 Compilation”. The reader is referred to Special Report 10 for more complete information on location, rock type, dating method, and literature references for each age entry. A listing of dates in Special Report lo which require correction or deletion is included S table 2. Corrected and additional entries are listed in table 3. The listings in tables 2 and 3 follow the format of Special Report 10. Table 4 is a glossary of abbreviations used for quadrangle name, rock type, mineral dated, and type of dating method used.

  13. Radiometric age map of northern Alaska

    USGS Publications Warehouse

    Wilson, Frederic H.; Turner, D.L.

    1975-01-01

    This map includes published, thesis, and open-file radiometric data available to us as of June, 1975. Some dates are not plotted because of inadequate location data in the original references.The map is divided into five sections, based on 1:1,000,000 scale enlargements of the National Atlas maps of Alaska. Within each section (e.g., southeastern Alaska), radiometric dates are plotted and keyed to 1:250,000 scale quadrangles. Accompanying each map section is table 1, listing map numbers and the sample identification numbers used in DGGS Special Report 10: Radiometric Dates from Alaska-A 1975 Compilation”. The reader is referred to Special Report 10 for more complete information on location, rock type, dating method, and literature references for each age entry. A listing of dates in Special Report lo which require correction or deletion is included S table 2. Corrected and additional entries are listed in table 3. The listings in tables 2 and 3 follow the format of Special Report 10. Table 4 is a glossary of abbreviations used for quadrangle name, rock type, mineral dated, and type of dating method used.

  14. Travels with Gates - August 2010

    Science.gov Websites

    combat floods that are affecting 14 million people. Story Biography Speeches Travels Photo Essays Gates Visits Navy Special Warefare Training More Photo Essays Gates Attends Graduation in San Diego Gates Photo Essays News Photos Week In Photos Videos DIMOC DOD/Military Seals DoD Flickr Secretary of Defense

  15. Defense.gov Special Report: Gates Bids Farewell to Troops

    Science.gov Websites

    service members and their families for their service. Gates will retire as secretary of defense on June 30 - Defense Secretary Robert M. Gates has served for four-and-a-half years -- longer than all but four of his of the Defense Department. He was focused almost exclusively on the war in Iraq. Story Gates' Bio

  16. 33 CFR 100.35 - Special local regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Special local regulations. 100.35 Section 100.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.35 Special local regulations. (a) The Commander...

  17. Regulation of Specialized Metabolism by WRKY Transcription Factors

    PubMed Central

    Schluttenhofer, Craig; Yuan, Ling

    2015-01-01

    WRKY transcription factors (TFs) are well known for regulating plant abiotic and biotic stress tolerance. However, much less is known about how WRKY TFs affect plant-specialized metabolism. Analysis of WRKY TFs regulating the production of specialized metabolites emphasizes the values of the family outside of traditionally accepted roles in stress tolerance. WRKYs with conserved roles across plant species seem to be essential in regulating specialized metabolism. Overall, the WRKY family plays an essential role in regulating the biosynthesis of important pharmaceutical, aromatherapy, biofuel, and industrial components, warranting considerable attention in the forthcoming years. PMID:25501946

  18. Nontimber forest product opportunities in Alaska.

    Treesearch

    David Pilz; Susan J. Alexander; Jerry Smith; Robert Schroeder; Jim Freed

    2006-01-01

    Nontimber forest products from southern Alaska (also called special forest products) have been used for millennia as resources vital to the livelihoods and culture of Alaska Natives and, more recently, as subsistence resources for the welfare of all citizens. Many of these products are now being sold, and Alaskans seek additional income opportunities through...

  19. Short-Term Synaptic Plasticity Regulation in Solution-Gated Indium-Gallium-Zinc-Oxide Electric-Double-Layer Transistors.

    PubMed

    Wan, Chang Jin; Liu, Yang Hui; Zhu, Li Qiang; Feng, Ping; Shi, Yi; Wan, Qing

    2016-04-20

    In the biological nervous system, synaptic plasticity regulation is based on the modulation of ionic fluxes, and such regulation was regarded as the fundamental mechanism underlying memory and learning. Inspired by such biological strategies, indium-gallium-zinc-oxide (IGZO) electric-double-layer (EDL) transistors gated by aqueous solutions were proposed for synaptic behavior emulations. Short-term synaptic plasticity, such as paired-pulse facilitation, high-pass filtering, and orientation tuning, was experimentally emulated in these EDL transistors. Most importantly, we found that such short-term synaptic plasticity can be effectively regulated by alcohol (ethyl alcohol) and salt (potassium chloride) additives. Our results suggest that solution gated oxide-based EDL transistors could act as the platforms for short-term synaptic plasticity emulation.

  20. Defense.gov Special Report: Travels with Gates - March 2011

    Science.gov Websites

    cadets. Story Gates: Scouting Instills Principles, Integrity, Honor DALLAS, March 4, 2011 - Defense Secretary Robert M. Gates praised the Boy Scouts of America for instilling principles, integrity and honor

  1. 36 CFR 13.958 - What other regulations apply to snowmachine use?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false What other regulations apply to snowmachine use? 13.958 Section 13.958 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Denali National Park and...

  2. 36 CFR 13.958 - What other regulations apply to snowmachine use?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false What other regulations apply to snowmachine use? 13.958 Section 13.958 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Denali National Park and...

  3. 36 CFR 13.958 - What other regulations apply to snowmachine use?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false What other regulations apply to snowmachine use? 13.958 Section 13.958 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Denali National Park and...

  4. CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates.

    PubMed Central

    Sugita, M; Yue, Y; Foskett, J K

    1998-01-01

    The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that is regulated by phosphorylation of the R domain and ATP hydrolysis at two nucleotide-binding domains (NBDs). It is controversial whether CFTR conducts ATP or whether CFTR might be closely associated with a separate ATP conductance. To characterize ATP channels associated with CFTR, we analyzed Cl- and ATP single channel-currents in excised inside-out membrane patches from MDCK epithelial cells transiently expressing CFTR. With 100 mM ATP in the pipette and 140 mM Cl- in the bath, ATP channels were associated with CFTR Cl- channels in two-thirds of patches that included CFTR. CFTR Cl- channels and CFTR-associated ATP channels had slope conductances of 7.4 pS and 5.2 pS, respectively, and had distinct reversal potentials and sensitivities to channel blockers. CFTR-associated ATP channels exhibited slow gating kinetics that depended on the presence of protein kinase A and cytoplasmic ATP, similar to CFTR Cl- channels. Gating kinetics of the ATP channels as well as the CFTR Cl- channels were similarly affected by non-hydrolyzable ATP analogues and mutations in the CFTR R domain and NBDs. Our results indicate that phosphorylation- and nucleotide-hydrolysis-dependent gating of CFTR is directly involved in gating of an associated ATP channel. However, the permeation pathways for Cl- and ATP are distinct and the ATP conduction pathway is not obligatorily associated with the expression of CFTR. PMID:9463368

  5. 14 CFR Appendix - Special Federal Aviation Regulation No. 60

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 60 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Special Federal Aviation Regulation No. 60...

  6. Unpacking the Placement of American Indian and Alaska Native Students in Special Education Programs and Services in the Early Grades: School Readiness as a Predictive Variable

    ERIC Educational Resources Information Center

    Hibel, Jacob; Faircloth, Susan C.; Farkas, George

    2008-01-01

    In this article, Jacob Hibel, Susan Faircloth, and George Farkas investigate the persistent finding that American Indian and Alaska Native (AI/AN) students are overrepresented in special education. Using data from the kindergarten cohort of the Early Childhood Longitudinal Study, the authors compare the third-grade special education placement rate…

  7. 77 FR 25075 - Special Local Regulation; Galveston Bay, Kemah, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ...-AA08 Special Local Regulation; Galveston Bay, Kemah, TX AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary special local regulation in Galveston Bay in the vicinity of Kemah, Texas. This temporary special local regulation is necessary to provide...

  8. How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?

    PubMed

    Besson, Pierre; Driffort, Virginie; Bon, Émeline; Gradek, Frédéric; Chevalier, Stéphan; Roger, Sébastien

    2015-10-01

    Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal isoforms, while they are not expressed, or only at a low level, in the matching normal tissue. The level of their expression and their activity is related to the aggressiveness of the disease and to the formation of metastases. A vast knowledge on the regulation of their expression and functioning has been accumulated in normal excitable cells. This helped understand their regulation in cancer cells. However, how voltage-gated sodium channels impose a pro-metastatic behavior to cancer cells is much less documented. This aspect will be addressed in the review. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. 76 FR 52563 - Special Local Regulations; Sabine River, Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ...-AA08 Special Local Regulations; Sabine River, Orange, TX AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard is establishing a temporary Special Local Regulation on the Sabine River within the Port Arthur, TX Captain of the Port Zone. This Special Local Regulation is intended to...

  10. 75 FR 55968 - Special Local Regulations, Sabine River; Orange, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ...-AA08 Special Local Regulations, Sabine River; Orange, TX AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary Special Local Regulation in the Port Arthur Captain of the Port Zone on the Sabine River, Orange, Texas. This Special Local Regulation is...

  11. 14 CFR Appendix - Special Federal Aviation Regulation No. 60

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 60 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Special Federal Aviation Regulation No. 60 Editorial Note: For the text of SFAR No. 60,...

  12. 14 CFR Appendix - Special Federal Aviation Regulation No. 60

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 60 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Special Federal Aviation Regulation No. 60 Editorial Note: For the text of SFAR No. 60,...

  13. 14 CFR Appendix - Special Federal Aviation Regulation No. 60

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 60 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Pt. 93, SFAR No. 60, Note Special Federal Aviation Regulation No. 60 Editorial Note: Fo...

  14. A fully on-chip fast-transient NMOS low dropout voltage regulator with quasi floating gate pass element

    NASA Astrophysics Data System (ADS)

    Wang, Han; Gou, Chao; Luo, Kai

    2017-04-01

    This paper presents a fully on-chip NMOS low-dropout regulator (LDO) for portable applications with quasi floating gate pass element and fast transient response. The quasi floating gate structure makes the gate of the NMOS transistor only periodically charged or refreshed by the charge pump, which allows the charge pump to be a small economical circuit with small silicon area. In addition, a variable reference circuit is introduced enlarging the dynamic range of error amplifier during load transient. The proposed LDO has been implemented in a 0.35 μm BCD process. From experimental results, the regulator can operate with a minimum dropout voltage of 250 mV at a maximum 1 A load and {I}{{Q}} of 395 μA. Under full-range load current step, the voltage undershoot and overshoot of the proposed LDO are reduced to 50 and 26 mV, respectively.

  15. 76 FR 62090 - Public Meeting for the National Park Service (NPS) Alaska Region's Subsistence Resource...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... Arctic Heritage Center, 171 Third Avenue in Kotzebue, Alaska, (907) 442-3890, on Thursday, November 17...' Workshop. 12. New Business. a. Gates of the Arctic National Park SRC Draft Hunting Plan Recommendation 10...

  16. Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation

    PubMed Central

    Fraser, Scott P.; Ozerlat-Gunduz, Iley; Brackenbury, William J.; Fitzgerald, Elizabeth M.; Campbell, Thomas M.; Coombes, R. Charles; Djamgoz, Mustafa B. A.

    2014-01-01

    Although ion channels are increasingly being discovered in cancer cells in vitro and in vivo, and shown to contribute to different aspects and stages of the cancer process, much less is known about the mechanisms controlling their expression. Here, we focus on voltage-gated Na+ channels (VGSCs) which are upregulated in many types of carcinomas where their activity potentiates cell behaviours integral to the metastatic cascade. Regulation of VGSCs occurs at a hierarchy of levels from transcription to post-translation. Importantly, mainstream cancer mechanisms, especially hormones and growth factors, play a significant role in the regulation. On the whole, in major hormone-sensitive cancers, such as breast and prostate cancer, there is a negative association between genomic steroid hormone sensitivity and functional VGSC expression. Activity-dependent regulation by positive feedback has been demonstrated in strongly metastatic cells whereby the VGSC is self-sustaining, with its activity promoting further functional channel expression. Such auto-regulation is unlike normal cells in which activity-dependent regulation occurs mostly via negative feedback. Throughout, we highlight the possible clinical implications of functional VGSC expression and regulation in cancer. PMID:24493753

  17. Defense.gov Special Report: Travels with Gates - March 2011

    Science.gov Websites

    in the U.S.-Israel relationship and the implications of dramatic Middle East political shifts were Barak. Story Gates: U.S.-Israeli Defense Relationship Never Stronger TEL AVIV, Israel, March 24, 2011 - Noting that their military relationship has never been stronger, Defense Secretary Robert M. Gates said

  18. 43 CFR 36.13 - Special provisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Arctic National Park and Preserve. (1) Access for surface transportation purposes across Gates of the Arctic National Park and Preserve (from the Ambler Mining District to the Alaska Pipeline Haul Road... economically feasible or otherwise reasonably available alternate route. (c) Oil and Gas Pipelines—Arctic Slope...

  19. 43 CFR 36.13 - Special provisions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Arctic National Park and Preserve. (1) Access for surface transportation purposes across Gates of the Arctic National Park and Preserve (from the Ambler Mining District to the Alaska Pipeline Haul Road... economically feasible or otherwise reasonably available alternate route. (c) Oil and Gas Pipelines—Arctic Slope...

  20. Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.

    PubMed

    Lee, Chien-Hsing; Huang, Po-Tsang; Liou, Horng-Huei; Lin, Mei-Ying; Lou, Kuo-Long; Chen, Chung-Yi

    2016-04-22

    The ROMK1 (Kir1.1) channel activity is predominantly regulated by intracellular pH (pHi) and phosphatidylinositol 4,5-bisphosphate (PIP2). Although several residues were reported to be involved in the regulation of pHi associated with PIP2 interaction, the detailed molecular mechanism remains unclear. We perform experiments in ROMK1 pHi-gating with electrophysiology combined with mutational and structural analysis. In the present study, non basic residues of C-terminal region (S219, N215, I192, L216 and L220) in ROMK1 channels have been found to mediate channel-PIP2 interaction and pHi gating. Further, our structural results show these residues with an appropriate distance to interact with membrane PIP2. Meanwhile, a cluster of basic residues (R188, R217 and K218), which was previously discovered regarding the interaction with PIP2, exists in this appropriate distance to discriminate the regulation of channel-PIP2 interaction and pHi-gating. This appropriate distance can be observed with high conservation in the Kir channel family. Our results provide insight that an appropriate distance cooperates with the electrostatics interaction of channel-PIP2 to regulate pHi-gating. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Defense.gov Special Report: Travels With Gates - May2011

    Science.gov Websites

    Flexibility, Gates Tells Airmen SEYMOUR JOHNSON AIR FORCE BASE, N.C., May 6, 2011 - The lesson Americans SEYMOUR JOHNSON AIR FORCE BASE, N.C., May 6, 2011 - The killing of Osama bin Laden "could be a game 336th fighter squadrons. Story | Transcript News Photos Photo Essays Gates Visits Seymour Johnson Air

  2. DIFMOS - A floating-gate electrically erasable nonvolatile semiconductor memory technology. [Dual Injector Floating-gate MOS

    NASA Technical Reports Server (NTRS)

    Gosney, W. M.

    1977-01-01

    Electrically alterable read-only memories (EAROM's) or reprogrammable read-only memories (RPROM's) can be fabricated using a single-level metal-gate p-channel MOS technology with all conventional processing steps. Given the acronym DIFMOS for dual-injector floating-gate MOS, this technology utilizes the floating-gate technique for nonvolatile storage of data. Avalanche injection of hot electrons through gate oxide from a special injector diode in each bit is used to charge the floating gates. A second injector structure included in each bit permits discharge of the floating gate by avalanche injection of holes through gate oxide. The overall design of the DIFMOS bit is dictated by the physical considerations required for each of the avalanche injector types. The end result is a circuit technology which can provide fully decoded bit-erasable EAROM-type circuits using conventional manufacturing techniques.

  3. Vocational and Special Education. Program Review. A Study Conducted on Behalf of the State of Alaska Department of Education--Dr. Marshall Lind, Commissioner.

    ERIC Educational Resources Information Center

    Martini and Associates, Ltd., Anchorage, AK.

    The State of Alaska Department of Education, through management consultants, conducted a study in eight selected school districts to ascertain the following: (1) effectiveness of vocational education programs offered at the secondary level, (2) adequacy of special education services provided to exceptional children at all levels, and (3)…

  4. 14 CFR Appendix - Special Federal Aviation Regulation No. 36

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 36 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Special Federal Aviation Regulation No. 36 Editorial Note...

  5. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Special Federal Aviation Regulation No. 108...

  6. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES TRAINING CENTERS Special Federal Aviation Regulation No. 93 Editorial Note...

  7. 14 CFR Appendix - Special Federal Aviation Regulation No. 36

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 36 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Special Federal Aviation Regulation No. 36 Editorial Note...

  8. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES TRAINING CENTERS Special Federal Aviation Regulation No. 93 Editorial Note...

  9. Defense.gov - Special Report: Travels with Gates

    Science.gov Websites

    security concerns. Story Gates Warns: Terror Syndicate Threatens to Destabilize South Asia NEW DELHI, Jan . 21, 2010 - An al-Qaida-backed terror syndicate is focused on destabilizing South Asia and stoking

  10. Publications - SR 67 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    DGGS SR 67 Publication Details Title: Alaska's mineral industry 2011 - exploration activity Authors the mineral industry. Please take time to fill out the current mining and mineral activity - exploration activity: Alaska Division of Geological & Geophysical Surveys Special Report 67, 10 p. http

  11. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 97 Editorial Note: For the...

  12. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 97 Editorial Note: For the...

  13. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 71 Editorial Note: For the...

  14. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  15. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 71 Editorial Note: For the...

  16. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 97 Editorial Note: For the...

  17. 14 CFR Appendix - Special Federal Aviation Regulation No. 13

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Pt. 25, SFAR No. 13 Special Federal Aviation Regulation No. 13 1...

  18. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  19. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 71 Editorial Note: For the...

  20. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  1. 14 CFR Appendix - Special Federal Aviation Regulation No. 13

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Pt. 25, SFAR No. 13 Special Federal Aviation Regulation No. 13 1...

  2. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  3. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 97 Editorial Note: For the...

  4. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 93 Editorial Note: For the...

  5. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  6. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 71 Editorial Note: For the...

  7. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  8. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  9. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  10. 14 CFR Appendix - Special Federal Aviation Regulation No. 13

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Pt. 25, SFAR No. 13 Special Federal Aviation Regulation No. 13 1...

  11. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 97 Editorial Note: For the...

  12. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  13. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  14. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  15. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 71 Editorial Note: For the...

  16. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  17. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 93 Editorial Note: For the...

  18. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  19. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  20. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES IFR ALTITUDES Special Federal Aviation Regulation No. 97 Editorial Note...

  1. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation Regulation No...

  2. 33 CFR 110.233 - Prince William Sound, Alaska.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...

  3. 33 CFR 110.233 - Prince William Sound, Alaska.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...

  4. 33 CFR 110.233 - Prince William Sound, Alaska.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...

  5. 33 CFR 110.233 - Prince William Sound, Alaska.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...

  6. 33 CFR 110.233 - Prince William Sound, Alaska.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...

  7. 14 CFR Appendix - Special Federal Aviation Regulation No. 36

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 36 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Pt. 121, SFAR No. 36 Special Federal Aviation Regulation No. 36 1...

  8. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE..., SFAR No. 97, Note Special Federal Aviation Regulation No. 97 Editorial Note: For the text of SFAR No...

  9. 14 CFR Appendix - Special Federal Aviation Regulation No. 36

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 36 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS..., FLAG, AND SUPPLEMENTAL OPERATIONS Pt. 121, SFAR No. 36 Special Federal Aviation Regulation No. 36 1...

  10. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE... Special Federal Aviation Regulation No. 97 Editorial Note: For the text of SFAR No. 97, see part 91 of...

  11. 14 CFR Appendix - Special Federal Aviation Regulation No. 13

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Pt. 25, SFAR No. 13 Special Federal Aviation Regulation No. 13 1. Applicability. Contrary provisions o...

  12. 14 CFR Appendix - Special Federal Aviation Regulation No. 13

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Pt. 25, SFAR No. 13 Special Federal Aviation Regulation No. 13 1. Applicability. Contrary provisions o...

  13. Facts About Alaska, Alaska Kids' Corner, State of Alaska

    Science.gov Websites

    Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees State of Alaska Search Home Quick Links Departments Commissioners Employee Whitepages State Government Jobs Federal Jobs Starting a Small Business Living Get a Driver License Get a Hunting

  14. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Special Federal Aviation Regulation No. 108 Note: For the text of SFAR No. 108,...

  15. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Special Federal Aviation Regulation No. 93 Editorial Note: For the text of SFAR No. 93, see...

  16. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Pt. 61, SFAR No. 108, Note Special Federal Aviation Regulation No. 108 Note: Fo...

  17. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Special Federal Aviation Regulation No. 93 Editorial Note: For the text of SFAR No. 93, see...

  18. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Special Federal Aviation Regulation No. 108 Note: For the text of SFAR No. 108,...

  19. Defense.gov - Special Report: Travels with Gates

    Science.gov Websites

    U.S. Role in Iraq Remains Critical, Gates Says KIRKUK, Iraq, Dec. 11, 2009 – The U.S. military role remains critical to preserving gains made in Iraq and helping to prevent sectarian violence in the roll-up

  20. Separate Gating Mechanisms Mediate the Regulation of K2P Potassium Channel TASK-2 by Intra- and Extracellular pH*

    PubMed Central

    Niemeyer, María Isabel; Cid, L. Pablo; Peña-Münzenmayer, Gaspar; Sepúlveda, Francisco V.

    2010-01-01

    TASK-2 (KCNK5 or K2P5.1) is a background K+ channel that is opened by extracellular alkalinization and plays a role in renal bicarbonate reabsorption and central chemoreception. Here, we demonstrate that in addition to its regulation by extracellular protons (pHo) TASK-2 is gated open by intracellular alkalinization. The following pieces of evidence suggest that the gating process controlled by intracellular pH (pHi) is independent from that under the command of pHo. It was not possible to overcome closure by extracellular acidification by means of intracellular alkalinization. The mutant TASK-2-R224A that lacks sensitivity to pHo had normal pHi-dependent gating. Increasing extracellular K+ concentration acid shifts pHo activity curve of TASK-2 yet did not affect pHi gating of TASK-2. pHo modulation of TASK-2 is voltage-dependent, whereas pHi gating was not altered by membrane potential. These results suggest that pHo, which controls a selectivity filter external gate, and pHi act at different gating processes to open and close TASK-2 channels. We speculate that pHi regulates an inner gate. We demonstrate that neutralization of a lysine residue (Lys245) located at the C-terminal end of transmembrane domain 4 by mutation to alanine abolishes gating by pHi. We postulate that this lysine acts as an intracellular pH sensor as its mutation to histidine acid-shifts the pHi-dependence curve of TASK-2 as expected from its lower pKa. We conclude that intracellular pH, together with pHo, is a critical determinant of TASK-2 activity and therefore of its physiological function. PMID:20351106

  1. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE DESIGNATION OF CLASS A, B, C, D, AND E AIRSPACE AREAS; AIR TRAFFIC SERVICE ROUTES; AND REPORTING POINTS Special Federal Aviation Regulation No....

  2. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE DESIGNATION OF CLASS A, B, C, D, AND E AIRSPACE AREAS; AIR TRAFFIC SERVICE ROUTES; AND REPORTING POINTS Special Federal Aviation Regulation No....

  3. Statewide Educator Supply & Demand Report, State of Alaska, 1998.

    ERIC Educational Resources Information Center

    LaBerge, MaryEllen

    In 1998, the demand for educators in Alaska reached an all-time high. The shortage was most critical for music, math, and special education teachers, as well as for counselors. Filling positions in rural areas is especially difficult. An early retirement incentive program has caused a drain on Alaska's pool of teachers. Factors that inhibit…

  4. 50 CFR 35.14 - Special regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the: (1) Legislative Record of the establishing Act. (2) Committee Reports of the Congress. (3) Departmental and Executive Reports to the Congress. (4) Other provisions. (c) Such special regulations shall be...

  5. 50 CFR 35.14 - Special regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the: (1) Legislative Record of the establishing Act. (2) Committee Reports of the Congress. (3) Departmental and Executive Reports to the Congress. (4) Other provisions. (c) Such special regulations shall be...

  6. 50 CFR 35.14 - Special regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the: (1) Legislative Record of the establishing Act. (2) Committee Reports of the Congress. (3) Departmental and Executive Reports to the Congress. (4) Other provisions. (c) Such special regulations shall be...

  7. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES IFR ALTITUDES Special Federal Aviation Regulation No. 97 Editorial Note: For the text of SFAR No. 97, see part 91...

  8. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES IFR ALTITUDES Pt. 95, SFAR No. 97, Note Special Federal Aviation Regulation No. 97 Editorial Note: For the text o...

  9. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES IFR ALTITUDES Special Federal Aviation Regulation No. 97 Editorial Note: For the text of SFAR No. 97, see part 91...

  10. 41 CFR 302-3.218 - Are there any special circumstances when my agency may authorize me travel and transportation...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false Are there any special... Alaska or Hawaii? 302-3.218 Section 302-3.218 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  11. 41 CFR 302-3.218 - Are there any special circumstances when my agency may authorize me travel and transportation...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false Are there any special... Alaska or Hawaii? 302-3.218 Section 302-3.218 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  12. 41 CFR 302-3.218 - Are there any special circumstances when my agency may authorize me travel and transportation...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true Are there any special... Alaska or Hawaii? 302-3.218 Section 302-3.218 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  13. 41 CFR 302-3.218 - Are there any special circumstances when my agency may authorize me travel and transportation...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false Are there any special... Alaska or Hawaii? 302-3.218 Section 302-3.218 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  14. Geologic maps of the eastern Alaska Range, Alaska (1:63,360 scale)

    USGS Publications Warehouse

    Nokleberg, Warren J.; Aleinikoff, John N.; Bond, Gerard C.; Ferrians, Oscar J.; Herzon, Paige L.; Lange, Ian M.; Miyaoka, Ronny T.; Richter, Donald H.; Schwab, Carl E.; Silva, Steven R.; Smith, Thomas E.; Zehner, Richard E.

    2015-01-01

    This report provides a description of map units for a suite of 44 inch-to-mile (1:63,360-scale) geologic quadrangle maps of the eastern Alaska Range. This report also contains a geologic and tectonic summary and a comprehensive list of references pertaining to geologic mapping and specialized studies of the region. In addition to the geologic maps of the eastern Alaska Range, this package includes a list of map units and an explanation of map symbols and abbreviations. The geologic maps display detailed surficial and bedrock geology, structural and stratigraphic data, portrayal of the active Denali fault that bisects the core of the east–west-trending range, and portrayal of other young faults along the north and south flanks of the range.

  15. DefenseLink.mil - Special Report: Travels with Gates

    Science.gov Websites

    , leaving the field to Boeing, but said the process was balanced. Story >> Gates Shares Insights From served eight presidents, and he shared some of his insights into that experience with U.S. servicemembers

  16. Sliding-gate valve for use with abrasive materials

    DOEpatents

    Ayers, Jr., William J.; Carter, Charles R.; Griffith, Richard A.; Loomis, Richard B.; Notestein, John E.

    1985-01-01

    The invention is a flow and pressure-sealing valve for use with abrasive solids. The valve embodies special features which provide for long, reliable operating lifetimes in solids-handling service. The valve includes upper and lower transversely slidable gates, contained in separate chambers. The upper gate provides a solids-flow control function, whereas the lower gate provides a pressure-sealing function. The lower gate is supported by means for (a) lifting that gate into sealing engagement with its seat when the gate is in its open and closed positions and (b) lowering the gate out of contact with its seat to permit abrasion-free transit of the gate between its open and closed positions. When closed, the upper gate isolates the lower gate from the solids. Because of this shielding action, the sealing surface of the lower gate is not exposed to solids during transit or when it is being lifted or lowered. The chamber containing the lower gate normally is pressurized slightly, and a sweep gas is directed inwardly across the lower-gate sealing surface during the vertical translation of the gate.

  17. Effect of special diabetes program for Indians funding on system changes in diabetes care and outcomes among American Indian/Alaska Native people 1994-2004.

    PubMed

    Ramesh, Meera; Schraer, Cynthia; Mayer, Ann Marie; Asay, Elvin; Koller, Kathryn

    2008-06-01

    The Alaska Native Medical Center diabetes program analysed Diabetes Care and Outcomes Audit data from 1994-2004 to evaluate the impact of the Special Diabetes Program for Indians (SDPI) funding on process and intermediate outcomes. We conducted a retrospective analysis of data from standardized medical records reviews conducted between 1994 and 2004 from regional sites in Alaska. We analysed 7,735 randomly selected records for trends over three time periods (pre-SDPI, transition and SDPI). Hemoglobin A1c, total and LDL cholesterol, triglycerides and blood pressure significantly improved from the pre-SDPI to the SDPI period. However, as the number of people with diabetes increased, the percentage of patients receiving foot, eye and dental exams decreased, as did the percentage receiving nutrition, exercise and diabetes education. SDPI funding provided resources for interventions necessary to improve the effectiveness of diabetes care. This was associated with improved intermediate outcomes in American Indian/Alaska Native patients with diabetes. Further observations are needed to evaluate whether or not intermediate outcomes result in decreased cardiovascular disease, amputations, dialysis and retinopathy.

  18. 76 FR 53886 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Special...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ...; Defense Federal Acquisition Regulation Supplement; Special Contracting Methods AGENCY: Defense Acquisition...-0214, using any of the following methods: [cir] Regulations.gov : http://www.regulations.gov . Follow... Supplement (DFARS) Part 217, Special Contracting Methods, and related provisions and clauses at DFARS 252.217...

  19. 78 FR 42451 - Special Local Regulations; Marine Events; Annual Bayview Mackinac Race

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ...-AA08 Special Local Regulations; Marine Events; Annual Bayview Mackinac Race AGENCY: Coast Guard, DHS... regulation for the annual Bayview Mackinac Race, from 9 a.m. to 5 p.m. on July 20, 2013. This special local regulated is necessary to [[Page 42452

  20. 75 FR 32661 - Special Local Regulation; Hydroplane Exhibition, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ...-AA08 Special Local Regulation; Hydroplane Exhibition, Detroit River, Detroit, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard will enforce a temporary special local regulation on the Detroit River, Detroit, Michigan from June 18, 2010 to June 20, 2010. This special local...

  1. Cyclic nucleotide- and inositol phosphate-gated ion channels in lobster olfactory receptor neurons.

    PubMed Central

    Hatt, H; Ache, B W

    1994-01-01

    The idea of having two second messenger pathways in olfaction, one mediated by cAMP and the other by inositol 1,4,5-trisphosphate, is supported by evidence that both second messengers directly activate distinct ion channels in the outer dendrite of lobster olfactory receptor neurons. Evidence that both types of second messenger-gated channels can occur in the same patch of membrane suggests that channels of both types can be expressed in one neuron. Evidence of more than one type of inositol phosphate-gated channel in this highly specialized region of the neuron furthers the idea that the output of individual olfactory receptor cells is regulated through multiple effectors and allows that effector diversity may contribute to functional diversity among olfactory receptor cells. Images PMID:7517547

  2. The Ca{sup 2+} channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Choi, Suzy; Kim, Hyun Jin, E-mail: kimhyunjin@skku.edu

    2014-01-03

    Highlights: •Split-ubiquitin MY2H screen identified GATE16 as an interacting protein of TRPML3. •TRPML3 specifically binds to a mammalian ATG8 homologue GATE16, not to LC3B. •The interaction of TRPML3 with GATE16 facilitates autophagosome formation. •GATE16 is expressed in both autophagosome and extra-autophagosomal compartments. -- Abstract: TRPML3 is a Ca{sup 2+} permeable cation channel expressed in multiple intracellular compartments. Although TRPML3 is implicated in autophagy, how TRPML3 can regulate autophagy is not understood. To search interacting proteins with TRPML3 in autophagy, we performed split-ubiquitin membrane yeast two-hybrid (MY2H) screening with TRPML3-loop as a bait and identified GATE16, a mammalian ATG8 homologue. GSTmore » pull-down assay revealed that TRPML3 and TRPML3-loop specifically bind to GATE16, not to LC3B. Co-immunoprecipitation (co-IP) experiments showed that TRPML3 and TRPML3-loop pull down only the lipidated form of GATE16, indicating that the interaction occurs exclusively at the organellar membrane. The interaction of TRPML3 with GATE16 and GATE16-positive vesicle formation were increased in starvation induced autophagy, suggesting that the interaction facilitates the function of GATE16 in autophagosome formation. However, GATE16 was not required for TRPML3 trafficking to autophagosomes. Experiments using dominant-negative (DN) TRPML3(D458K) showed that GATE16 is localized not only in autophagosomes but also in extra-autophagosomal compartments, by contrast with LC3B. Since GATE16 acts at a later stage of the autophagosome biogenesis, our results suggest that TRPML3 plays a role in autophagosome maturation through the interaction with GATE16, by providing Ca{sup 2+} in the fusion process.« less

  3. The Alaska SAR processor - Operations and control

    NASA Technical Reports Server (NTRS)

    Carande, Richard E.

    1989-01-01

    The Alaska SAR (synthetic-aperture radar) Facility (ASF) will be capable of receiving, processing, archiving, and producing a variety of SAR image products from three satellite-borne SARs: E-ERS-1 (ESA), J-ERS-1 (NASDA) and Radarsat (Canada). Crucial to the success of the ASF is the Alaska SAR processor (ASP), which will be capable of processing over 200 100-km x 100-km (Seasat-like) frames per day from the raw SAR data, at a ground resolution of about 30 m x 30 m. The processed imagery is of high geometric and radiometric accuracy, and is geolocated to within 500 m. Special-purpose hardware has been designed to execute a SAR processing algorithm to achieve this performance. This hardware is currently undergoing acceptance testing for delivery to the University of Alaska. Particular attention has been devoted to making the operations semi-automated and to providing a friendly operator interface via a computer workstation. The operations and control of the Alaska SAR processor are described.

  4. Defense.gov - Special Report - Travels With Gates

    Science.gov Websites

    Force Base, Ala. Story» Warfighter Care at Center of 2010 Budget Considerations MAXWELL AIR FORCE BASE , Ala., April 15, 2009 – Defense Secretary Robert M. Gates met at Maxwell Air Force Base, Ala., with the U.S. Air Force Air War College on Maxwell Air Force Base, Ala., listen to Defense Secretary Robert

  5. DefenseLink.mil - Special Report: Travels with Gates

    Science.gov Websites

    Robert M. Gates said here today. Story >> Iran Puts Middle East Security at Risk ANKARA, Turkey , Feb. 6, 2010 – Iran’s nuclear program continues to put security in the Middle East at risk despite

  6. Gates Travels to Asia - November 5, 2007: Department of Defense Special

    Science.gov Websites

    Robert M. Gates and Japanese Defense Minister Shigeru Ishiba met here today to discuss the Japanese war dead today and met with South Korean defense leaders to discuss the strong U.S.-Korean alliance civilian and military leaders. Gates and his delegation will discuss a full range of regional and global

  7. Alaska Department of Revenue - Alaska Film Office

    Science.gov Websites

    State Employees Alaska Film Office Alaska Film Office State of Alaska HOME CREDIT PROGRAM PUBLIC REPORTING CPA ECONOMIC DEVELOPMENT CONTACT US State of Alaska > Department of Revenue > Alaska Film Office > Text Size: A+ | A- | A Text Only Effective July 1, 2015, the film production incentive

  8. 43 CFR 2091.9-1 - Alaska Native selections.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SPECIAL LAWS AND RULES Segregation and Opening of Lands § 2091.9-1 Alaska Native selections. The segregation and opening of lands authorized for...

  9. National Association Links, Alaska Oil and Gas Conservation Commission,

    Science.gov Websites

    Oil and Gas Conservation Commission Alaska Department of Administration, Alaska Oil and Gas Guidelines Regulatory Regulations Statutes Industry Guidance Bulletins Memorandums of Agreement Links Oil Field Terms (Schlumberger) Spot Price Information (DOE) West Coast Price - NS Oil (DOR) Calendar State

  10. DefenseLink.mil - Special Report - Travels With Gates

    Science.gov Websites

    Hamad Al-Khalifa, during the International Institute for Stategic Studies' fifth annual Manama Dialogue Hamad Al-Khalifa, during the International Institute for Stategic Studies' fifth annual Manama Dialogue Secretary Robert M. Gates gives a speech during the opening of International Institute for Stategic Studies

  11. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  12. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND FOREIGN OPERATORS OF U.S.-REGISTERED AIRCRAFT ENGAGED IN COMMON CARRIAGE Special Federal Aviation...

  13. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES IFR ALTITUDES Pt. 95, SFAR No. 97, Note Special Federal Aviation...

  14. 14 CFR Appendix - Special Federal Aviation Regulation No. 36

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 36 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  15. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  16. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  17. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  18. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  19. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  20. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  1. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  2. 14 CFR Appendix - Special Federal Aviation Regulation No. 36

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 36 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  3. 14 CFR Appendix - Special Federal Aviation Regulation No. 93

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 93 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  4. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  5. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  6. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  7. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  8. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  9. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  10. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  11. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND FOREIGN OPERATORS OF U.S.-REGISTERED AIRCRAFT ENGAGED IN COMMON CARRIAGE Special Federal Aviation...

  12. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  13. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  14. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND FOREIGN OPERATORS OF U.S.-REGISTERED AIRCRAFT ENGAGED IN COMMON CARRIAGE Special Federal Aviation...

  15. 14 CFR Appendix - Special Federal Aviation Regulation No. 106

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 106 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  16. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  17. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  18. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  19. 14 CFR Appendix - Special Federal Aviation Regulation No. 71

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  20. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND FOREIGN OPERATORS OF U.S.-REGISTERED AIRCRAFT ENGAGED IN COMMON CARRIAGE Special Federal Aviation...

  1. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  2. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  3. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND FOREIGN OPERATORS OF U.S.-REGISTERED AIRCRAFT ENGAGED IN COMMON CARRIAGE Special Federal Aviation...

  4. 14 CFR Appendix - Special Federal Aviation Regulation No. 89

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 89 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  5. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Special Federal Aviation...

  6. Reading Gate Positions with a Smartphone

    NASA Astrophysics Data System (ADS)

    van Overloop, Peter-Jules; Hut, Rolf

    2015-04-01

    Worldwide many flow gates are built in water networks in order to direct water to appropriate locations. Most of these gates are adjusted manually by field operators of water management organizations and it is often centrally not known what the new position of the gate is. This makes centralized management of the entire water network difficult. One of the reasons why the measurement of the gate position is usually not executed, is that for certain gates it is not easy to do such a reading. Tilting weirs or radial gates are examples where operators need special equipment (measuring rod and long level) to determine the position and it could even be a risky procedure. Another issue is that once the measurement is done, the value is jotted down in a notebook and later, at the office, entered in a computer system. So the entire monitoring procedure is not real-time and prone to human errors. A new way of monitoring gate positions is introduced. It consists of a level that is attached to the gate and an app with which a picture can be taken from the level. Using dedicated pattern recognition algorithms, the gate position can be read by using the angle of the level versus reference points on the gate, the radius of that gate and the absolute level of the joint around which the gate turn. The method uses gps-localization of the smartphone to store the gate position in the right location in the central database.

  7. DefenseLink Special: Travels with Gates, February 2007

    Science.gov Websites

    to address the 43rd Munich Conference on Security Policy, Feb. 10 and 11, in Munich, Germany. Feb. 12 , the secretary traveled to Pakistan to meet with Pakistan President Pervez Musharaff to discuss border security on the Pakistan-Afghanistan border. Islamabad, Pakistan Gates, Pakistani President Discuss Border

  8. DefenseLink.mil - Special Report - Travels With Gates

    Science.gov Websites

    Force in Afghanistan to the NATO and partner-nation defense ministers here today.Story New Memorial Attends NATO Defense Ministers' Conference Gates Tours Netherlands American Cemetery and Memorial MEMORIAL DEDICATION - NATO officials dedicate a memorial to those who have lost their lives in alliance operations

  9. Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors

    PubMed Central

    Moreau, Christophe J.; Revilloud, Jean; Caro, Lydia N.; Dupuis, Julien P.; Trouchet, Amandine; Estrada-Mondragón, Argel; Nieścierowicz, Katarzyna; Sapay, Nicolas; Crouzy, Serge; Vivaudou, Michel

    2017-01-01

    Ligand-gated ion channels enable intercellular transmission of action potential through synapses by transducing biochemical messengers into electrical signal. We designed artificial ligand-gated ion channels by coupling G protein-coupled receptors to the Kir6.2 potassium channel. These artificial channels called ion channel-coupled receptors offer complementary properties to natural channels by extending the repertoire of ligands to those recognized by the fused receptors, by generating more sustained signals and by conferring potassium selectivity. The first artificial channels based on the muscarinic M2 and the dopaminergic D2L receptors were opened and closed by acetylcholine and dopamine, respectively. We find here that this opposite regulation of the gating is linked to the length of the receptor C-termini, and that C-terminus engineering can precisely control the extent and direction of ligand gating. These findings establish the design rules to produce customized ligand-gated channels for synthetic biology applications. PMID:28145461

  10. 78 FR 35135 - Special Local Regulation; Kelley's Island Swim, Lake Erie; Kelley's Island, Lakeside, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ...-AA08 Special Local Regulation; Kelley's Island Swim, Lake Erie; Kelley's Island, Lakeside, OH AGENCY... vessel movement in portions of Lake Erie during the annual Kelley's Island Swim from. This special local... special local regulations listed in 33 CFR 100.921 Special Local Regulation; Kelley's Island Swim, Lake...

  11. Defense.gov Special Report: Parade Honors Robert M. Gates

    Science.gov Websites

    Medal of Freedom WASHINGTON - At his Armed Forces Farewell Tribute on the Pentagon's parade field Pentagon farewell ceremony at which Gates was awarded the Presidential Medal of Freedom. Story Mullen Lauds

  12. Mechanical gating of a mechanochemical reaction cascade

    NASA Astrophysics Data System (ADS)

    Wang, Junpeng; Kouznetsova, Tatiana B.; Boulatov, Roman; Craig, Stephen L.

    2016-11-01

    Covalent polymer mechanochemistry offers promising opportunities for the control and engineering of reactivity. To date, covalent mechanochemistry has largely been limited to individual reactions, but it also presents potential for intricate reaction systems and feedback loops. Here we report a molecular architecture, in which a cyclobutane mechanophore functions as a gate to regulate the activation of a second mechanophore, dichlorocyclopropane, resulting in a mechanochemical cascade reaction. Single-molecule force spectroscopy, pulsed ultrasonication experiments and DFT-level calculations support gating and indicate that extra force of >0.5 nN needs to be applied to a polymer of gated gDCC than of free gDCC for the mechanochemical isomerization gDCC to proceed at equal rate. The gating concept provides a mechanism by which to regulate stress-responsive behaviours, such as load-strengthening and mechanochromism, in future materials designs.

  13. 77 FR 6007 - Quarterly Listings; Safety Zones, Security Zones, Special Local Regulations, Drawbridge Operation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ...] Quarterly Listings; Safety Zones, Security Zones, Special Local Regulations, Drawbridge Operation... they could be published in the Federal Register. This notice lists temporary safety zones, security zones, special local regulations, drawbridge operation regulations and regulated navigation areas, all...

  14. 33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

  15. 33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

  16. 33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

  17. 33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

  18. 33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

  19. Defense.gov Special Report: Travels with Gates - April 2011

    Science.gov Websites

    partner nations. Here's a look at Secretary Gates' latest travels. Top Stories Services Must Balance Old the right balance between the new capabilities they've had to develop in Iraq and Afghanistan while

  20. 33 CFR 100.1307 - Special Local Regulations, Strait Thunder Performance, Port Angeles, WA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. 100.1307 Section 100.1307 Navigation and Navigable Waters COAST... § 100.1307 Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. (a) Regulated Areas...

  1. 33 CFR 100.1307 - Special Local Regulations, Strait Thunder Performance, Port Angeles, WA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. 100.1307 Section 100.1307 Navigation and Navigable Waters COAST... § 100.1307 Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. (a) Regulated Areas...

  2. 33 CFR 100.1307 - Special Local Regulations, Strait Thunder Performance, Port Angeles, WA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. 100.1307 Section 100.1307 Navigation and Navigable Waters COAST... § 100.1307 Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. (a) Regulated Areas...

  3. 33 CFR 100.1307 - Special Local Regulations, Strait Thunder Performance, Port Angeles, WA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. 100.1307 Section 100.1307 Navigation and Navigable Waters COAST... § 100.1307 Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. (a) Regulated Areas...

  4. 33 CFR 100.1307 - Special Local Regulations, Strait Thunder Performance, Port Angeles, WA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. 100.1307 Section 100.1307 Navigation and Navigable Waters COAST... § 100.1307 Special Local Regulations, Strait Thunder Performance, Port Angeles, WA. (a) Regulated Areas...

  5. 50 CFR 37.32 - Special areas.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... NATIONAL WILDLIFE REFUGE SYSTEM GEOLOGICAL AND GEOPHYSICAL EXPLORATION OF THE COASTAL PLAIN, ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.32 Special areas. (a) Caribou calving and post-calving special areas. The Regional Director shall designate within the coastal plain specific...

  6. 50 CFR 37.32 - Special areas.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... NATIONAL WILDLIFE REFUGE SYSTEM GEOLOGICAL AND GEOPHYSICAL EXPLORATION OF THE COASTAL PLAIN, ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.32 Special areas. (a) Caribou calving and post-calving special areas. The Regional Director shall designate within the coastal plain specific...

  7. 50 CFR 37.32 - Special areas.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... NATIONAL WILDLIFE REFUGE SYSTEM GEOLOGICAL AND GEOPHYSICAL EXPLORATION OF THE COASTAL PLAIN, ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.32 Special areas. (a) Caribou calving and post-calving special areas. The Regional Director shall designate within the coastal plain specific...

  8. 50 CFR 37.32 - Special areas.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... NATIONAL WILDLIFE REFUGE SYSTEM GEOLOGICAL AND GEOPHYSICAL EXPLORATION OF THE COASTAL PLAIN, ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.32 Special areas. (a) Caribou calving and post-calving special areas. The Regional Director shall designate within the coastal plain specific...

  9. 50 CFR 37.32 - Special areas.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... NATIONAL WILDLIFE REFUGE SYSTEM GEOLOGICAL AND GEOPHYSICAL EXPLORATION OF THE COASTAL PLAIN, ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.32 Special areas. (a) Caribou calving and post-calving special areas. The Regional Director shall designate within the coastal plain specific...

  10. 33 CFR 100.1302 - Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. 100.1302 Section 100.1302 Navigation and Navigable Waters COAST... § 100.1302 Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. (a) Regulated area. All...

  11. 33 CFR 100.1302 - Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. 100.1302 Section 100.1302 Navigation and Navigable Waters COAST... § 100.1302 Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. (a) Regulated area. All...

  12. 33 CFR 100.1302 - Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. 100.1302 Section 100.1302 Navigation and Navigable Waters COAST... § 100.1302 Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. (a) Regulated area. All...

  13. 33 CFR 100.1302 - Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. 100.1302 Section 100.1302 Navigation and Navigable Waters COAST... § 100.1302 Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. (a) Regulated area. All...

  14. 33 CFR 100.1302 - Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. 100.1302 Section 100.1302 Navigation and Navigable Waters COAST... § 100.1302 Special Local Regulation, Annual Dragon Boat Races, Portland, Oregon. (a) Regulated area. All...

  15. 14 CFR Appendix - Special Federal Aviation Regulation No. 108

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 108 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN... Aviation Regulation No. 108 Note: For the text of SFAR No. 108, see part 91 of this chapter. ...

  16. 14 CFR Appendix - Special Federal Aviation Regulation No. 97

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE DESIGNATION OF CLASS A, B, C, D, AND E AIRSPACE AREAS; AIR TRAFFIC SERVICE ROUTES; AND REPORTING POINTS Pt. 71, SFAR No. 97, Note Special Federa...

  17. 78 FR 59902 - Regulated Navigation Area; Special Buzzards Bay Vessel Regulation, Buzzards Bay, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-0322] RIN 1625-AA11 Regulated Navigation Area; Special Buzzards Bay Vessel Regulation, Buzzards Bay, MA AGENCY: Coast Guard, DHS. ACTION: Notice of extension of comment period. SUMMARY: The Coast Guard is extending the...

  18. Methamphetamine acutely inhibits voltage-gated calcium channels but chronically up-regulates L-type channels.

    PubMed

    Andres, Marilou A; Cooke, Ian M; Bellinger, Frederick P; Berry, Marla J; Zaporteza, Maribel M; Rueli, Rachel H; Barayuga, Stephanie M; Chang, Linda

    2015-07-01

    In neurons, calcium (Ca(2+) ) channels regulate a wide variety of functions ranging from synaptic transmission to gene expression. They also induce neuroplastic changes that alter gene expression following psychostimulant administration. Ca(2+) channel blockers have been considered as potential therapeutic agents for the treatment of methamphetamine (METH) dependence because of their ability to reduce drug craving among METH users. Here, we studied the effects of METH exposure on voltage-gated Ca(2+) channels using SH-SY5Y cells as a model of dopaminergic neurons. We found that METH has different short- and long-term effects. A short-term effect involves immediate (< 5 min) direct inhibition of Ca(2+) ion movements through Ca(2+) channels. Longer exposure to METH (20 min or 48 h) selectively up-regulates the expression of only the CACNA1C gene, thus increasing the number of L-type Ca(2+) channels. This up-regulation of CACNA1C is associated with the expression of the cAMP-responsive element-binding protein (CREB), a known regulator of CACNA1C gene expression, and the MYC gene, which encodes a transcription factor that putatively binds to a site proximal to the CACNA1C gene transcription initiation site. The short-term inhibition of Ca(2+) ion movement and later, the up-regulation of Ca(2+) channel gene expression together suggest the operation of cAMP-responsive element-binding protein- and C-MYC-mediated mechanisms to compensate for Ca(2+) channel inhibition by METH. Increased Ca(2+) current density and subsequent increased intracellular Ca(2+) may contribute to the neurodegeneration accompanying chronic METH abuse. Methamphetamine (METH) exposure has both short- and long-term effects. Acutely, methamphetamine directly inhibits voltage-gated calcium channels. Chronically, neurons compensate by up-regulating the L-type Ca(2+) channel gene, CACNA1C. This compensatory mechanism is mediated by transcription factors C-MYC and CREB, in which CREB is linked to the

  19. 14 CFR Appendix - Special Federal Aviation Regulation No. 60

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 60 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... Aviation Regulation No. 60 Editorial Note: For the text of SFAR No. 60, see part 91 of this chapter. ...

  20. 75 FR 8329 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    .... TransCanada Alaska Company LLC (TC Alaska) has recently filed its request for approval of its Open...-Filing Workshop is attached. There will be no discussion of TC Alaska's filing in Docket No. PF09-11-001...

  1. 77 FR 71531 - Special Local Regulation; Kelley's Island Swim, Lake Erie; Kelley's Island, Lakeside, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ...-AA08 Special Local Regulation; Kelley's Island Swim, Lake Erie; Kelley's Island, Lakeside, OH AGENCY... part 100 by adding a Special Local Regulation within the Captain of the Port Detroit Zone. This... Swim. This special local regulated area is necessary to protect swimmers from vessel traffic. DATES...

  2. 78 FR 20849 - Special Local Regulations; Marine Events, Potomac River; National Harbor Access Channel, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ...-AA08 Special Local Regulations; Marine Events, Potomac River; National Harbor Access Channel, MD AGENCY... special local regulations during the ``Swim Across the Potomac'' swimming competition, to be held on the waters of the Potomac River on June 2, 2013. These special local regulations are necessary to provide for...

  3. 7 CFR 318.13-21 - Avocados from Hawaii to Alaska.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Avocados from Hawaii to Alaska. 318.13-21 Section 318... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE STATE OF HAWAII AND TERRITORIES QUARANTINE NOTICES Regulated Articles From Hawaii and the Territories § 318.13-21 Avocados from Hawaii to Alaska. Avocados may be moved...

  4. 77 FR 25077 - Special Local Regulation; Wy-Hi Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ...-AA08 Special Local Regulation; Wy-Hi Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI..., during, and immediately after the Wy-Hi Rowing Regatta. This special local regulation will establish....35T09-0342 Special Local Regulation; Wy-Hi Rowing Regatta, Wyandotte, MI. (a) Regulated Area. A...

  5. 77 FR 25073 - Special Local Regulation; Hebda Cup Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ...-AA08 Special Local Regulation; Hebda Cup Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI..., during, and immediately after the Hebda Cup Rowing Regatta. This special local regulation will establish....35T09-0340 Special Local Regulation; Hebda Cup Rowing Regatta, Wyandotte, MI. (a) Regulated area. A...

  6. 76 FR 27284 - Special Local Regulation; Partnership in Education, Dragon Boat Race; Maumee River, Toledo, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ...-AA08 Special Local Regulation; Partnership in Education, Dragon Boat Race; Maumee River, Toledo, OH... establishing a permanent Special Local Regulation on the Maumee River, Toledo, Ohio. This regulation is... place during the third or fourth weekend in July each year. This special local regulated area is...

  7. Staff - Robert J. Gillis | Alaska Division of Geological & Geophysical

    Science.gov Websites

    the hydrocarbon potential of Alaska's sedimentary basins and reconstruct their geologic histories. My : Sedimentary Geology, Special Volume 182, p. 87-100. http://dx.doi.org/10.1016/j.sedgeo.2005.07.013 Selected

  8. 78 FR 39588 - Special Local Regulations; Revision of 2013 America's Cup Regulated Area, San Francisco Bay; San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ...-AA08 Special Local Regulations; Revision of 2013 America's Cup Regulated Area, San Francisco Bay; San...: The Coast Guard is revising the regulated area for the 2013 America's Cup sailing events. Previously... final rule regulating the on-water activities associated with the ``Louis Vuitton Cup,'' ``Red Bull...

  9. 78 FR 57061 - Special Local Regulation; Red Bull Flugtag Miami, Biscayne Bay; Miami, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    .... The economic impact of this rule is not significant for the following reasons: (1) The special local... 1625-AA08 Special Local Regulation; Red Bull Flugtag Miami, Biscayne Bay; Miami, FL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a special local regulation...

  10. 75 FR 2126 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre-Filing Workshop January 5, 2010. On January 12, 2010... and process for commenting upon and holding an open season for an Alaska Natural Gas Transportation...

  11. 75 FR 6370 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre-Filing Workshop February 2, 2010. On February 11, 2010... and process for holding and commenting on an open season for an Alaska Natural Gas Transportation...

  12. Defense.gov Special Report: Travels with Gates - March 2011

    Science.gov Websites

    Troops Expand Security in Afghanistan NATO Ministers to Discuss Afghanistan, Libya Secretary Addresses , Karzai Discuss Civilian Casualties Secretary Fields Questions at Bagram Airfield Gates Arrives in FEAR Act Plain Writing Act of 2010 Accessibility/Section 508 Join the Military Careers Web Policy Stay

  13. 76 FR 9221 - Special Local Regulations; Patriot Challenge Kayak Race, Ashley River, Charleston, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ...-AA08 Special Local Regulations; Patriot Challenge Kayak Race, Ashley River, Charleston, SC AGENCY... regulations for the Patriot Challenge Kayak Race in Charleston, SC. The race will take place on April 10, 2011... navigable waters during the race. These special local regulations will temporarily restrict vessel traffic...

  14. Alaska, Naturally Occurring Asbestos: Experiences, Policy and 2012 Limitation of Liability Legislation

    NASA Astrophysics Data System (ADS)

    Hargesheimer, J.; Perkins, R.

    2012-12-01

    Naturally Occurring Asbestos (NOA) occurs in mineral deposits in Alaska. There are many regions in Alaska that have minerals in surface rocks that may contain asbestos and asbestos has been discovered in many locations in Alaska. Gravel is constantly in demand for heavy construction projects, but some remote localities in Alaska do not have gravel sources that are NOA-free. Determining if NOA can be safely used in heavy construction materials and what can or should be done with NOA materials that are already in place are complex questions. Answers will depend on the amount and type of asbestos mineral, how it is handled in processing, and how it is maintained - all subject to regulation and control of operations. The State of Alaska recently enacted legislation (HB 258) providing, among other things, "… immunity for the state and for landowners, extractors, suppliers, transporters, and contractors for certain actions or claims arising in connection with the use of gravel or aggregate material containing naturally occurring asbestos in certain areas." Implementation of the law and interim regulations and guidance should enable use of NOA for heavy construction materials in Alaska, but as with any new law, it will take some time to understand its full scope and effect.

  15. 76 FR 39289 - Special Local Regulation; Detroit APBA Gold Cup, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ...-AA08 Special Local Regulation; Detroit APBA Gold Cup, Detroit River, Detroit, MI AGENCY: Coast Guard... immediately after the Detroit APBA Gold Cup boat race. This special local regulation will establish... entry found in 33 CFR 100.918, Detroit APBA Gold Cup, Detroit, MI. Currently, the regulations located at...

  16. 75 FR 39448 - Special Local Regulation; Detroit APBA Gold Cup, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ...-AA08 Special Local Regulation; Detroit APBA Gold Cup, Detroit River, Detroit, MI AGENCY: Coast Guard... APBA Gold Cup. This special local regulation is necessary to protect spectators and vessels from the... Regulation; Detroit APBA Gold Cup, Detroit River, Detroit, MI in the Federal Register (75 FR 21191). We...

  17. 78 FR 21258 - Special Local Regulations; Patriot Challenge Kayak Race, Ashley River; Charleston, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ...-AA08 Special Local Regulations; Patriot Challenge Kayak Race, Ashley River; Charleston, SC AGENCY... regulation for the Patriot Challenge Kayak Race in Charleston, SC. The race will take place on April 13, 2013... navigable waters of the United States during the race. The special local regulation will temporarily...

  18. Evolutionarily conserved intracellular gate of voltage-dependent sodium channels

    NASA Astrophysics Data System (ADS)

    Oelstrom, Kevin; Goldschen-Ohm, Marcel P.; Holmgren, Miguel; Chanda, Baron

    2014-03-01

    Members of the voltage-gated ion channel superfamily (VGIC) regulate ion flux and generate electrical signals in excitable cells by opening and closing pore gates. The location of the gate in voltage-gated sodium channels, a founding member of this superfamily, remains unresolved. Here we explore the chemical modification rates of introduced cysteines along the S6 helix of domain IV in an inactivation-removed background. We find that state-dependent accessibility is demarcated by an S6 hydrophobic residue; substituted cysteines above this site are not modified by charged thiol reagents when the channel is closed. These accessibilities are consistent with those inferred from open- and closed-state structures of prokaryotic sodium channels. Our findings suggest that an intracellular gate composed of a ring of hydrophobic residues is not only responsible for regulating access to the pore of sodium channels, but is also a conserved feature within canonical members of the VGIC superfamily.

  19. Defense.gov Special Report: Travels With Gates - January 2011

    Science.gov Websites

    officials will take the military-to-military relationship between the two countries to the next level. Story traveling to China, where he will seek to expand and deepen the military-to-military relationship between weapons to Taiwan. Story | Transcript More Headlines Gates Seeks Sustained Military Relationship with

  20. Defense.gov Special Report: Travels with Gates - June 2011

    Science.gov Websites

    Endorses Decision to Extend Libya Operation Through Early Fall BRUSSELS, June 8, 2011 - NATO Secretary Operation Unified Protector in Libya by 90 days. Story Gates Says Coalition, Afghans Can Turn Corner in Available jobs with DOD Top Issues Targeted Operations Against ISIL Terrorists Operation Atlantic Resolve

  1. Defense.gov Special Report: Travels with Gates - December 2010

    Science.gov Websites

    Says Gates Salutes Sailors, Marines at Afghanistan Base Secretary Presents Valor Awards to Bastogne at the U.S. Embassy, Kabul Remarks at Forward Operating Base Howz-e-Madad, Afghanistan Remarks at Base Joyce, Afghanistan Remarks at Forward Operating Base Connolly, Afghanistan Media Availabilty at

  2. 77 FR 6708 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... local regulations during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on the waters of the Potomac River on June 2, 2012. These special local regulations are necessary to...

  3. Defense.gov Special Report: Travels with Gates - October 2010

    Science.gov Websites

    issues. Story MIA Issue Aided U.S.-Vietnam Relationship HANOI, Vietnam, Oct. 11, 2010 - Efforts to recover those missing from the Vietnam War have helped to transform the U.S.-Vietnamese relationship since . Gates noted the level of cooperation in the military relationship between the United States and Vietnam

  4. Defense.gov Special Report: Travels with Gates - November 2010

    Science.gov Websites

    military can offer a wealth of experience in disaster relief operations to the United States and other Relationship SANTIAGO, Chile, Nov. 19, 2010 - U.S. Defense Secretary Robert M. Gates' trip to Santiago, Chile , is intended to reinforce an already strong military relationship between the two countries, and find

  5. 78 FR 25572 - Special Local Regulation; Wy-Hi Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ...-AA08 Special Local Regulation; Wy-Hi Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI..., during, and immediately after the Wy-Hi Rowing Regatta. This special local regulation will establish... to read as follows: Sec. 100.T09-0287 Special Local Regulation; Wy-Hi Rowing Regatta, Wyandotte, MI...

  6. 77 FR 39630 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... 1625-AA08 Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel... special local regulations during the swim segment of the ``Swim Across the Potomac River'' swimming competition, to be held on the waters of the Potomac River on July 8, 2012. These special local regulations...

  7. 75 FR 39445 - Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair, Harrison Township, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ...-AA08 Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair, Harrison Township, MI... temporary special local regulation in the Captain of the Port Detroit Zone on Lake St. Clair, Harrison Township, Michigan. This special local regulation is intended to restrict vessels from portions of Lake St...

  8. 75 FR 21194 - Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair; Harrison Township, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ...-AA08 Special Local Regulation; Harrison Township Grand Prix, Lake St. Clair; Harrison Township, MI... establishing a temporary special local regulation in the Captain of the Port Detroit Zone on Lake St. Clair... Lake St. Clair during the Harrison Township Grand Prix. This special local regulation is necessary to...

  9. 75 FR 41789 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ...-AA08 Special Local Regulations for Marine Events; Patuxent River, Solomons, MD AGENCY: Coast Guard, DHS... proposed special local regulations for the ``Chesapeake Challenge'' power boat races, a marine event to be... proposal adds an additional date to the ``Chesapeake Challenge'' power boat racing on October 3, 2010...

  10. Alaska Air National Guard

    Science.gov Websites

    Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska Symbol Visit 168th Wing Website State of Alaska myAlaska My Government Resident Business in Alaska

  11. Role of lake regulation on glacier fed rivers in enhancing salmon productivity: The Cook Inlet watershed south central Alaska, USA

    USGS Publications Warehouse

    Hupp, C.R.

    2000-01-01

    Rivers fed by glaciers constitute a major part of the freshwater runoff into the Cook Inlet basin of south-central Alaska. This basin is very important to the economy of the State of Alaska because it is home to more than half of the population and it supports multi-million dollar commercial, subsistence and sport fisheries. Hence an understanding of how glacial runoff influences biological productivity is important for managing rivers that drain into Cook Inlet. This paper examines the ways in which the regulation of glacier-fed rivers by proglacial lakes affects salmon productivity, with particular reference to the Kenai River. Salmon escapement per unit channel length on the Kenai River is between two and ten times that found for rain-and-snowmelt dominated rivers and glacier-fed rivers lacking lake regulation. Lakes are shown to influence biological processes in glacier-fed rivers by attenuating peak flows, sustaining high flows throughout the summer, supplementing winter low flows, settling suspended sediment, and increasing river temperatures. Downstream from large lakes, glacier-fed rivers are less disturbed, channels are relatively stable and have well-developed salmonid habitats. The positive influences are indicated by the high diversity and abundances of benthic macroinvertebrates, which are important food resources for juvenile salmonids. High summer flows allow access for up-river salmon runs and lakes also provide both overwintering and rearing habitat. Copyright ?? 2000 John Wiley & Sons, Ltd.Rivers fed by glaciers constitute a major part of the freshwater runoff into the Cook Inlet basin of south-central Alaska. This basin is very important to the economy of the State of Alaska because it is home to more than half of the population and it supports multi-million dollar commercial, subsistence and sport fisheries. Hence an understanding of how glacial runoff influences biological productivity is important for managing rivers that drain into Cook Inlet

  12. 33 CFR 100.902 - Special Local Regulations; Annual Bayview Mackinac Race.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Bayview Mackinac Race. 100.902 Section 100.902 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Regulations; Annual Bayview Mackinac Race. (a) Regulated area. These Special Local Regulations apply to all U... will be enforced annually at the commencement of the Bayview Mackinac Race. The enforcement period will...

  13. 33 CFR 100.902 - Special Local Regulations; Annual Bayview Mackinac Race.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Bayview Mackinac Race. 100.902 Section 100.902 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Regulations; Annual Bayview Mackinac Race. (a) Regulated area. These Special Local Regulations apply to all U... will be enforced annually at the commencement of the Bayview Mackinac Race. The enforcement period will...

  14. 33 CFR 100.902 - Special Local Regulations; Annual Bayview Mackinac Race.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Bayview Mackinac Race. 100.902 Section 100.902 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Regulations; Annual Bayview Mackinac Race. (a) Regulated area. These Special Local Regulations apply to all U... will be enforced annually at the commencement of the Bayview Mackinac Race. The enforcement period will...

  15. Reciprocal Regulation of Reactive Oxygen Species and Phospho-CREB Regulates Voltage Gated Calcium Channel Expression during Mycobacterium tuberculosis Infection

    PubMed Central

    Selvakumar, Arti; Antony, Cecil; Singhal, Jhalak; Tiwari, Brijendra K.; Singh, Yogendra; Natarajan, Krishnamurthy

    2014-01-01

    Our previous work has demonstrated the roles played by L-type Voltage Gated Calcium Channels (VGCC) in regulating Mycobacterium tuberculosis (M. tb) survival and pathogenesis. Here we decipher mechanisms and pathways engaged by the pathogen to regulate VGCC expression in macrophages. We show that M. tb and its antigen Rv3416 use phospho-CREB (pCREB), Reactive Oxygen Species (ROS), Protein Kinase C (PKC) and Mitogen Activated Protein Kinase (MAPK) to modulate VGCC expression in macrophages. siRNA mediated knockdown of MyD88, IRAK1, IRAK2 or TRAF6 significantly inhibited antigen mediated VGCC expression. Inhibiting Protein Kinase C (PKC) or MEK-ERK1/2 further increased VGCC expression. Interestingly, inhibiting intracellular calcium release upregulated antigen mediated VGCC expression, while inhibiting extracellular calcium influx had no significant effect. siRNA mediated knockdown of transcription factors c-Jun, SOX5 and CREB significantly inhibited Rv3416 mediated VGCC expression. A dynamic reciprocal cross-regulation between ROS and pCREB was observed that in turn governed VGCC expression with ROS playing a limiting role in the process. Further dissection of the mechanisms such as the interplay between ROS and pCREB would improve our understanding of the regulation of VGCC expression during M. tb infection. PMID:24797940

  16. Field surveying and topographic mapping in Alaska: 1947-83

    USGS Publications Warehouse

    Foley, Robert C.

    1987-01-01

    This circular retraces surveying and topographic mapping by the Geological Survey in Alaska from 1947 to 1983 and describes camp life and some of the unusual happenings involved in working in virtually uninhabited country, adverse weather, and difficult terrain. A year-by-year recap of activities documents the transition from early small-scale mapping efforts to more accurate and detailed 1:63,360-scale mapping for Alaska except the Aleutian Islands and isolated islands in the Bering Sea. Recent 1:25,000-scale metric mapping and the preparation of orthophotographs and special mapping efforts for other Government agencies also are recounted.

  17. Gate modulation of proton transport in a nanopore.

    PubMed

    Mei, Lanju; Yeh, Li-Hsien; Qian, Shizhi

    2016-03-14

    Proton transport in confined spaces plays a crucial role in many biological processes as well as in modern technological applications, such as fuel cells. To achieve active control of proton conductance, we investigate for the first time the gate modulation of proton transport in a pH-regulated nanopore by a multi-ion model. The model takes into account surface protonation/deprotonation reactions, surface curvature, electroosmotic flow, Stern layer, and electric double layer overlap. The proposed model is validated by good agreement with the existing experimental data on nanopore conductance with and without a gate voltage. The results show that the modulation of proton transport in a nanopore depends on the concentration of the background salt and solution pH. Without background salt, the gated nanopore exhibits an interesting ambipolar conductance behavior when pH is close to the isoelectric point of the dielectric pore material, and the net ionic and proton conductance can be actively regulated with a gate voltage as low as 1 V. The higher the background salt concentration, the lower is the performance of the gate control on the proton transport.

  18. 77 FR 63720 - Special Local Regulations; 2012 Ironman 70.3 Miami, Biscayne Bay; Miami, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    .... The economic impact of this rule is not significant for the following reasons: (1) The special local...-AA08 Special Local Regulations; 2012 Ironman 70.3 Miami, Biscayne Bay; Miami, FL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a special local regulation...

  19. Defense.gov Special Report: Travels with Gates - May 2011

    Science.gov Websites

    Notre Dame. Story Gates Keeps Promise to Open Elementary School at Fort Riley FORT RILEY, Kan., May 20 last year to open a new elementary school there. Story Secretary Urges Careful Thought in Spending Military/DOD Social Media Sites Register A Site Unified Combatant Commands Contact Us Frequently Asked

  20. State of Alaska

    Science.gov Websites

    Alaska Railroad Alaska Maps Alaska Travel Safety Information Alaska Fish and Game Alaska Facts & Month Services How Do I? Education Health Jobs Safety How Do I? Apply for a Permanent Fund Dividend File Information More Dept. of Commerce, Comm... More Dept. of Labor & Workforce Dev. Safety 511 - Traveler

  1. 75 FR 75658 - Approval and Promulgation of Implementation Plans; Alaska: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... Significant Deterioration (PSD) program to reflect changes to the Federal PSD program relating to the... update Alaska's PSD program to reflect changes to the Federal PSD program that would authorize the State of Alaska to regulate GHGs under its PSD program and establish appropriate emission thresholds for...

  2. GeoFORCE Alaska, A Successful Summer Exploring Alaska's Geology

    NASA Astrophysics Data System (ADS)

    Wartes, D.

    2012-12-01

    Thirty years old this summer, RAHI, the Rural Alaska Honors Institute is a statewide, six-week, summer college-preparatory bridge program at the University of Alaska Fairbanks for Alaska Native and rural high school juniors and seniors. This summer, in collaboration with the University of Texas Austin, the Rural Alaska Honors Institute launched a new program, GeoFORCE Alaska. This outreach initiative is designed to increase the number and diversity of students pursuing STEM degree programs and entering the future high-tech workforce. It uses Earth science to entice kids to get excited about dinosaurs, volcanoes and earthquakes, and includes physics, chemistry, math, biology and other sciences. Students were recruited from the Alaska's Arctic North Slope schools, in 8th grade to begin the annual program of approximately 8 days, the summer before their 9th grade year and then remain in the program for all four years of high school. They must maintain a B or better grade average and participate in all GeoFORCE events. The culmination is an exciting field event each summer. Over the four-year period, events will include trips to Fairbanks and Anchorage, Arizona, Oregon and the Appalachians. All trips focus on Earth science and include a 100+ page guidebook, with tests every night culminating with a final exam. GeoFORCE Alaska was begun by the University of Alaska Fairbanks in partnership with the University of Texas at Austin, which has had tremendous success with GeoFORCE Texas. GeoFORCE Alaska is managed by UAF's long-standing Rural Alaska Honors Institute, that has been successfully providing intense STEM educational opportunities for Alaskan high school students for over 30 years. The program will add a new cohort of 9th graders each year for the next four years. By the summer of 2015, GeoFORCE Alaska is targeting a capacity of 160 students in grades 9th through 12th. Join us to find out more about this exciting new initiative, which is enticing young Alaska Native

  3. Universal fault-tolerant quantum computation with only transversal gates and error correction.

    PubMed

    Paetznick, Adam; Reichardt, Ben W

    2013-08-30

    Transversal implementations of encoded unitary gates are highly desirable for fault-tolerant quantum computation. Though transversal gates alone cannot be computationally universal, they can be combined with specially distilled resource states in order to achieve universality. We show that "triorthogonal" stabilizer codes, introduced for state distillation by Bravyi and Haah [Phys. Rev. A 86, 052329 (2012)], admit transversal implementation of the controlled-controlled-Z gate. We then construct a universal set of fault-tolerant gates without state distillation by using only transversal controlled-controlled-Z, transversal Hadamard, and fault-tolerant error correction. We also adapt the distillation procedure of Bravyi and Haah to Toffoli gates, improving on existing Toffoli distillation schemes.

  4. 78 FR 67026 - Special Local Regulations; Recurring Marine Events in the Seventh Coast Guard District

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... special local regulations pertaining to the Key West World Championship in the Atlantic Ocean, off Key...-speed boat races. The special local regulations establish regulated areas on the waters of the Key West Main Ship Channel, Key West Turning Basin, and Key West Harbor Entrance. During the enforcement period...

  5. 77 FR 15258 - Special Local Regulations; Patriot Challenge Kayak Race, Ashley River, Charleston, SC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ...-AA08 Special Local Regulations; Patriot Challenge Kayak Race, Ashley River, Charleston, SC AGENCY... regulations on the Ashley River in Charleston, South Carolina during the Patriot Challenge Kayak Race on... Challenge Kayak Race. Participant paddle boats will include kayaks, canoes, and paddleboards. These special...

  6. 75 FR 13454 - Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ...-AA08 Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY AGENCY: Coast... navigable waters of Huntington Bay, New York due to the annual Fran Schnarr Open Water Championships. The..., ``Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY'' (Docket number USCG...

  7. 75 FR 21191 - Special Local Regulation; Detroit APBA Gold Cup, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ...-AA08 Special Local Regulation; Detroit APBA Gold Cup, Detroit River, Detroit, MI AGENCY: Coast Guard... the Detroit APBA Gold Cup. This special local regulation is necessary to protect spectators and... race in conjunction with the Detroit APBA Gold Cup. The powerboat race and associated testing will...

  8. 33 CFR 334.1325 - United States Army Restricted Area, Kuluk Bay, Adak, Alaska.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Area, Kuluk Bay, Adak, Alaska. 334.1325 Section 334.1325 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1325 United States Army Restricted Area, Kuluk Bay, Adak, Alaska. (a) The area. The area within a...

  9. 33 CFR 334.1325 - United States Army Restricted Area, Kuluk Bay, Adak, Alaska.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Area, Kuluk Bay, Adak, Alaska. 334.1325 Section 334.1325 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1325 United States Army Restricted Area, Kuluk Bay, Adak, Alaska. (a) The area. The area within a...

  10. 33 CFR 334.1325 - United States Army Restricted Area, Kuluk Bay, Adak, Alaska.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Area, Kuluk Bay, Adak, Alaska. 334.1325 Section 334.1325 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1325 United States Army Restricted Area, Kuluk Bay, Adak, Alaska. (a) The area. The area within a...

  11. Home - Gold mining in Alaska - Libraries, Archives, & Museums at Alaska

    Science.gov Websites

    State Library Skip to main content State of Alaska myAlaska Departments State Employees Statewide Links × Upcoming Holiday Closure for Memorial Day The Alaska State Libraries, Archives, & Tuesday, May 29. Department of Education and Early Development Alaska State Libraries, Archives, and

  12. 77 FR 12477 - Subsistence Management Regulations for Public Lands in Alaska-Subpart C-Board Determinations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ....gov . For questions specific to National Forest System lands, contact Steve Kessler, Regional... or more on the economy or adversely affect an economic sector, productivity, jobs, the environment...; Jerry Berg, Alaska Regional Office, U.S. Fish and Wildlife Service; and Steve Kessler, Alaska Regional...

  13. 50 CFR 92.30 - General overview of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... closure to protect nesting birds. The Co-management Council will review and, if necessary, recommend... (CONTINUED) MISCELLANEOUS PROVISIONS MIGRATORY BIRD SUBSISTENCE HARVEST IN ALASKA Annual Regulations.../summer migratory bird subsistence harvest in Alaska. The regulations list migratory bird species that are...

  14. Alaska Tidal Datum Portal - Alaska Tidal Datum Calculator | Alaska Division

    Science.gov Websites

    Coastal Hazards Program Guide to Geologic Hazards in Alaska MAPTEACH Tsunami Inundation Mapping Energy Portal main content Alaska Tidal Datum Portal Unambiguous vertical datums in the coastal environment are projects to ensure protection of human life, property, and the coastal environment. January 2017 - Update

  15. Alaska Power Administration combined financial statements, schedules and supplemental reports, September 30, 1995 and 1994

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-12-31

    This report presents the results of the independent certified public accountant`s audit of the Department of Energy`s Alaska Power Administration`s (Alaska) financial statements as of September 30, 1995. The auditors have expressed an unqualified opinion on the 1995 statements. Their reports on Alaska`s internal control structure and on compliance with laws and regulations are also provided. The Alaska Power Administration operates and maintains two hydroelectric projects that include five generator units, three power tunnels and penstocks, and over 88 miles of transmission line. Additional information about Alaska Power Administration is provided in the notes to the financial statements. The 1995more » financial statement audit was made under the provisions of the Inspector General Act (5 U.S.C. App.), as amended, the Chief Financial Officers (CFO) Act (31 U.S.C. 1500), and Office of Management and Budget implementing guidance to the CFO Act. The auditor`s work was conducted in accordance with generally accepted government auditing standards. To fulfill the audit responsibilities, the authors contracted with the independent public accounting firm of KPMG Peat Marwick (KPMG) to conduct the audit for us, subject to review. The auditor`s report on Alaska`s internal control structure disclosed no reportable conditions that could have a material effect on the financial statements. The auditor also considered the overview and performance measure data for completeness and material consistency with the basic financial statements, as noted in the internal control report. The auditor`s report on compliance with laws and regulations disclosed no instances of noncompliance by Alaska.« less

  16. SU-E-T-350: Verification of Gating Performance of a New Elekta Gating Solution: Response Kit and Catalyst System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xie, X; Cao, D; Housley, D

    2014-06-01

    Purpose: In this work, we have tested the performance of new respiratory gating solutions for Elekta linacs. These solutions include the Response gating and the C-RAD Catalyst surface mapping system.Verification measurements have been performed for a series of clinical cases. We also examined the beam on latency of the system and its impact on delivery efficiency. Methods: To verify the benefits of tighter gating windows, a Quasar Respiratory Motion Platform was used. Its vertical-motion plate acted as a respiration surrogate and was tracked by the Catalyst system to generate gating signals. A MatriXX ion-chamber array was mounted on its longitudinal-movingmore » platform. Clinical plans are delivered to a stationary and moving Matrix array at 100%, 50% and 30% gating windows and gamma scores were calculated comparing moving delivery results to the stationary result. It is important to note that as one moves to tighter gating windows, the delivery efficiency will be impacted by the linac's beam-on latency. Using a specialized software package, we generated beam-on signals of lengths of 1000ms, 600ms, 450ms, 400ms, 350ms and 300ms. As the gating windows get tighter, one can expect to reach a point where the dose rate will fall to nearly zero, indicating that the gating window is close to beam-on latency. A clinically useful gating window needs to be significantly longer than the latency for the linac. Results: As expected, the use of tighter gating windows improved delivery accuracy. However, a lower limit of the gating window, largely defined by linac beam-on latency, exists at around 300ms. Conclusion: The Response gating kit, combined with the C-RAD Catalyst, provides an effective solution for respiratorygated treatment delivery. Careful patient selection, gating window design, even visual/audio coaching may be necessary to ensure both delivery quality and efficiency. This research project is funded by Elekta.« less

  17. 77 FR 23599 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard...; telephone 410-576-2674, email Ronald.L[email protected] . If you have questions on viewing the docket, call... ``Special Local Regulations for Marine Events; Potomac River, Charles County, MD'' in the Federal Register...

  18. 76 FR 15214 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on the waters of the Potomac River. These special local regulations are necessary to provide for the safety of life on...

  19. 78 FR 34886 - Special Local Regulations; Recurring Marine Events in the Seventh Coast Guard District

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... pertaining to the Beaufort Water Festival from 1 p.m. through 4 p.m. on July 27, 2013. This action is... Festival Air Show. During the enforcement period, the special local regulation establishes a regulated area... special local regulation for the Beaufort Water Festival in 33 CFR 100.701 Table 1 from 1:00 p.m. through...

  20. Home, Alaska Oil and Gas Conservation Commission, State of Alaska

    Science.gov Websites

    State logo Alaska Department of Administration Alaska Oil and Gas Conservation Commission Administration AOGCC Alaska Oil and Gas Conservation Commission Javascript is required to run this webpage

  1. Earthquakes in Alaska

    USGS Publications Warehouse

    Haeussler, Peter J.; Plafker, George

    1995-01-01

    Earthquake risk is high in much of the southern half of Alaska, but it is not the same everywhere. This map shows the overall geologic setting in Alaska that produces earthquakes. The Pacific plate (darker blue) is sliding northwestward past southeastern Alaska and then dives beneath the North American plate (light blue, green, and brown) in southern Alaska, the Alaska Peninsula, and the Aleutian Islands. Most earthquakes are produced where these two plates come into contact and slide past each other. Major earthquakes also occur throughout much of interior Alaska as a result of collision of a piece of crust with the southern margin.

  2. 14 CFR 91.1603 - Special Federal Aviation Regulation No. 112-Prohibition Against Certain Flights Within the...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 112... 91.1603 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Aviation Regulations § 91.1603 Special Federal Aviation Regulation No. 112—Prohibition Against Certain...

  3. 14 CFR 91.1603 - Special Federal Aviation Regulation No. 112-Prohibition Against Certain Flights Within the...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 112... 91.1603 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Aviation Regulations § 91.1603 Special Federal Aviation Regulation No. 112—Prohibition Against Certain...

  4. 14 CFR 91.1603 - Special Federal Aviation Regulation No. 112-Prohibition Against Certain Flights Within the...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Special Federal Aviation Regulation No. 112... 91.1603 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Aviation Regulations § 91.1603 Special Federal Aviation Regulation No. 112—Prohibition Against Certain...

  5. Public Education in Alaska. Bulletin, 1936, No. 12

    ERIC Educational Resources Information Center

    Office of Education, United States Department of the Interior, 1936

    1936-01-01

    Among areas governed by the United States, Alaska is unique in a number of ways; one of special interest to education officials and students is concerned with the maintenance within its borders of two publicly supported school systems--one by the Federal Government and one by the Territory. It was chiefly in the interest of the former that the…

  6. 78 FR 34570 - Special Local Regulations; Pro Hydro-X Tour, Lake Dora; Tavares, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ...-AA08 Special Local Regulations; Pro Hydro-X Tour, Lake Dora; Tavares, FL AGENCY: Coast Guard, DHS... waters of Lake Dora in Tavares, Florida, during the Pro Hydro-X Tour, a series of high-speed personal... published a notice of proposed rulemaking (NPRM) entitled Special Local Regulations; Pro Hydro-X Tour, Lake...

  7. Gating the glutamate gate of CLC-2 chloride channel by pore occupancy

    PubMed Central

    De Jesús-Pérez, José J.; Castro-Chong, Alejandra; Shieh, Ru-Chi; Hernández-Carballo, Carmen Y.; De Santiago-Castillo, José A.

    2016-01-01

    CLC-2 channels are dimeric double-barreled chloride channels that open in response to hyperpolarization. Hyperpolarization activates protopore gates that independently regulate the permeability of the pore in each subunit and the common gate that affects the permeability through both pores. CLC-2 channels lack classic transmembrane voltage–sensing domains; instead, their protopore gates (residing within the pore and each formed by the side chain of a glutamate residue) open under repulsion by permeant intracellular anions or protonation by extracellular H+. Here, we show that voltage-dependent gating of CLC-2: (a) is facilitated when permeant anions (Cl−, Br−, SCN−, and I−) are present in the cytosolic side; (b) happens with poorly permeant anions fluoride, glutamate, gluconate, and methanesulfonate present in the cytosolic side; (c) depends on pore occupancy by permeant and poorly permeant anions; (d) is strongly facilitated by multi-ion occupancy; (e) is absent under likely protonation conditions (pHe = 5.5 or 6.5) in cells dialyzed with acetate (an impermeant anion); and (f) was the same at intracellular pH 7.3 and 4.2; and (g) is observed in both whole-cell and inside-out patches exposed to increasing [Cl−]i under unlikely protonation conditions (pHe = 10). Thus, based on our results we propose that hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores, and that protonation by extracellular H+ plays a minor role in dislodging the glutamate gate. PMID:26666914

  8. Summary appraisals of the Nation's ground-water resources; Alaska

    USGS Publications Warehouse

    Zenone, Chester; Anderson, Gary S.

    1978-01-01

    Present deficiencies in the ground-water information base are obvious limiting factors to ground-water development in Alaska. There is a need to extend the ground-water data-collection network and to pursue special research into the quantitative aspects of ground-water hydrology in cold regions, particularly the continuous permafrost zone.

  9. 50 CFR 92.1 - Purpose of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) MISCELLANEOUS PROVISIONS MIGRATORY BIRD SUBSISTENCE HARVEST IN ALASKA General Provisions § 92.1 Purpose of regulations. The regulations in this part implement the Alaska migratory bird subsistence program as provided for in Article II(4)(b) of the 1916 Convention for the Protection of Migratory Birds in Canada and the...

  10. 50 CFR 92.1 - Purpose of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) MISCELLANEOUS PROVISIONS MIGRATORY BIRD SUBSISTENCE HARVEST IN ALASKA General Provisions § 92.1 Purpose of regulations. The regulations in this part implement the Alaska migratory bird subsistence program as provided for in Article II(4)(b) of the 1916 Convention for the Protection of Migratory Birds in Canada and the...

  11. Scalable uniform construction of highly conditional quantum gates

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ivanov, Svetoslav S.; Vitanov, Nikolay V.

    2011-08-15

    We present a scalable uniform technique for the construction of highly conditional multiply-controlled-not quantum gates of trapped ion qubits, such as the Toffoli gate, without using ancilla states and circuits of an exorbitant number of concatenated one- and two-qubit gates. Apart from the initial dressing of the internal qubit states with vibrational phonons and the final restoration of the phonon ground state, our technique requires the application of just a single composite pulse on the target qubit and is applicable both in and outside the Lamb-Dicke regime. We design special narrowband composite pulses, which suppress all transitions but the conditionalmore » transition of the target qubit; moreover, these composite pulses significantly improve the spatial addressing selectivity.« less

  12. Alaska and the Alaska Federal Health Care Partnership

    DTIC Science & Technology

    2002-08-01

    SUPPLEMENTARY NOTES The original document contains color images. 14. ABSTRACT The intent of the Alaska Federal Healthcare Partnership is to expand clinical and... intent of the Alaska Federal Healthcare Partnership is to expand clinical and support capabilities of the Alaska Native Medical Center (ANMC), Third...the formation of the Partnership. Although lengthy, the information is essential to appreciate the magnitude of the Partnership and the intent behind

  13. The Impact of Gate Width Setting and Gate Utilization Factors on Plutonium Assay in Passive Correlated Neutron Counting

    DOE PAGES

    Henzlova, Daniela; Menlove, Howard Olsen; Croft, Stephen; ...

    2015-06-15

    In the field of nuclear safeguards, passive neutron multiplicity counting (PNMC) is a method typically employed in non-destructive assay (NDA) of special nuclear material (SNM) for nonproliferation, verification and accountability purposes. PNMC is generally performed using a well-type thermal neutron counter and relies on the detection of correlated pairs or higher order multiplets of neutrons emitted by an assayed item. To assay SNM, a set of parameters for a given well-counter is required to link the measured multiplicity rates to the assayed item properties. Detection efficiency, die-away time, gate utilization factors (tightly connected to die-away time) as well as optimummore » gate width setting are among the key parameters. These parameters along with the underlying model assumptions directly affect the accuracy of the SNM assay. In this paper we examine the role of gate utilization factors and the single exponential die-away time assumption and their impact on the measurements for a range of plutonium materials. In addition, we examine the importance of item-optimized coincidence gate width setting as opposed to using a universal gate width value. Finally, the traditional PNMC based on multiplicity shift register electronics is extended to Feynman-type analysis and application of this approach to Pu mass assay is demonstrated.« less

  14. Role of lake regulation on glacier-fed rivers in enhancing salmon productivity: the Cook Inlet watershed, south-central Alaska, USA

    NASA Astrophysics Data System (ADS)

    Dorava, Joseph M.; Milner, Alexander M.

    2000-10-01

    Rivers fed by glaciers constitute a major part of the freshwater runoff into the Cook Inlet basin of south-central Alaska. This basin is very important to the economy of the State of Alaska because it is home to more than half of the population and it supports multi-million dollar commercial, subsistence and sport fisheries. Hence an understanding of how glacial runoff influences biological productivity is important for managing rivers that drain into Cook Inlet. This paper examines the ways in which the regulation of glacier-fed rivers by proglacial lakes affects salmon productivity, with particular reference to the Kenai River. Salmon escapement per unit channel length on the Kenai River is between two and ten times that found for rain-and-snowmelt dominated rivers and glacier-fed rivers lacking lake regulation.Lakes are shown to influence biological processes in glacier-fed rivers by attenuating peak flows, sustaining high flows throughout the summer, supplementing winter low flows, settling suspended sediment, and increasing river temperatures. Downstream from large lakes, glacier-fed rivers are less disturbed, channels are relatively stable and have well-developed salmonid habitats. The positive influences are indicated by the high diversity and abundances of benthic macroinvertebrates, which are important food resources for juvenile salmonids. High summer flows allow access for up-river salmon runs and lakes also provide both overwintering and rearing habitat.

  15. Beta-Estradiol Regulates Voltage-Gated Calcium Channels and Estrogen Receptors in Telocytes from Human Myometrium.

    PubMed

    Banciu, Adela; Banciu, Daniel Dumitru; Mustaciosu, Cosmin Catalin; Radu, Mihai; Cretoiu, Dragos; Xiao, Junjie; Cretoiu, Sanda Maria; Suciu, Nicolae; Radu, Beatrice Mihaela

    2018-05-09

    Voltage-gated calcium channels and estrogen receptors are essential players in uterine physiology, and their association with different calcium signaling pathways contributes to healthy and pathological conditions of the uterine myometrium. Among the properties of the various cell subtypes present in human uterine myometrium, there is increasing evidence that calcium oscillations in telocytes (TCs) contribute to contractile activity and pregnancy. Our study aimed to evaluate the effects of beta-estradiol on voltage-gated calcium channels and estrogen receptors in TCs from human uterine myometrium and to understand their role in pregnancy. For this purpose, we employed patch-clamp recordings, ratiometric Fura-2-based calcium imaging analysis, and qRT-PCR techniques for the analysis of cultured human myometrial TCs derived from pregnant and non-pregnant uterine samples. In human myometrial TCs from both non-pregnant and pregnant uterus, we evidenced by qRT-PCR the presence of genes encoding for voltage-gated calcium channels (Cav3.1, Ca3.2, Cav3.3, Cav2.1), estrogen receptors (ESR1, ESR2, GPR30), and nuclear receptor coactivator 3 (NCOA3). Pregnancy significantly upregulated Cav3.1 and downregulated Cav3.2, Cav3.3, ESR1, ESR2, and NCOA3, compared to the non-pregnant condition. Beta-estradiol treatment (24 h, 10, 100, 1000 nM) downregulated Cav3.2, Cav3.3, Cav1.2, ESR1, ESR2, GRP30, and NCOA3 in TCs from human pregnant uterine myometrium. We also confirmed the functional expression of voltage-gated calcium channels by patch-clamp recordings and calcium imaging analysis of TCs from pregnant human myometrium by perfusing with BAY K8644, which induced calcium influx through these channels. Additionally, we demonstrated that beta-estradiol (1000 nM) antagonized the effect of BAY K8644 (2.5 or 5 µM) in the same preparations. In conclusion, we evidenced the presence of voltage-gated calcium channels and estrogen receptors in TCs from non-pregnant and pregnant human

  16. Flexible Proton-Gated Oxide Synaptic Transistors on Si Membrane.

    PubMed

    Zhu, Li Qiang; Wan, Chang Jin; Gao, Ping Qi; Liu, Yang Hui; Xiao, Hui; Ye, Ji Chun; Wan, Qing

    2016-08-24

    Ion-conducting materials have received considerable attention for their applications in fuel cells, electrochemical devices, and sensors. Here, flexible indium zinc oxide (InZnO) synaptic transistors with multiple presynaptic inputs gated by proton-conducting phosphorosilicate glass-based electrolyte films are fabricated on ultrathin Si membranes. Transient characteristics of the proton gated InZnO synaptic transistors are investigated, indicating stable proton-gating behaviors. Short-term synaptic plasticities are mimicked on the proposed proton-gated synaptic transistors. Furthermore, synaptic integration regulations are mimicked on the proposed synaptic transistor networks. Spiking logic modulations are realized based on the transition between superlinear and sublinear synaptic integration. The multigates coupled flexible proton-gated oxide synaptic transistors may be interesting for neuroinspired platforms with sophisticated spatiotemporal information processing.

  17. 75 FR 748 - Special Local Regulation for Marine Events; Recurring Marine Events in the Fifth Coast Guard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-06

    ...-AA08 Special Local Regulation for Marine Events; Recurring Marine Events in the Fifth Coast Guard... recurring marine events within the Fifth Coast Guard District. These regulations make minor changes to the regulated areas of two permitted marine events listed in the table attached to the regulation. These special...

  18. Alaska Volcano Observatory

    USGS Publications Warehouse

    Venezky, Dina Y.; Murray, Tom; Read, Cyrus

    2008-01-01

    Steam plume from the 2006 eruption of Augustine volcano in Cook Inlet, Alaska. Explosive ash-producing eruptions from Alaska's 40+ historically active volcanoes pose hazards to aviation, including commercial aircraft flying the busy North Pacific routes between North America and Asia. The Alaska Volcano Observatory (AVO) monitors these volcanoes to provide forecasts of eruptive activity. AVO is a joint program of the U.S. Geological Survey (USGS), the Geophysical Institute of the University of Alaska Fairbanks (UAFGI), and the State of Alaska Division of Geological and Geophysical Surveys (ADGGS). AVO is one of five USGS Volcano Hazards Program observatories that monitor U.S. volcanoes for science and public safety. Learn more about Augustine volcano and AVO at http://www.avo.alaska.edu.

  19. The HOOK region of voltage-gated Ca2+ channel β subunits senses and transmits PIP2 signals to the gate.

    PubMed

    Park, Cheon-Gyu; Park, Yongsoo; Suh, Byung-Chang

    2017-02-01

    The β subunit of voltage-gated Ca 2+ (Ca V ) channels plays an important role in regulating gating of the α1 pore-forming subunit and its regulation by phosphatidylinositol 4,5-bisphosphate (PIP 2 ). Subcellular localization of the Ca V β subunit is critical for this effect; N-terminal-dependent membrane targeting of the β subunit slows inactivation and decreases PIP 2 sensitivity. Here, we provide evidence that the HOOK region of the β subunit plays an important role in the regulation of Ca V biophysics. Based on amino acid composition, we broadly divide the HOOK region into three domains: S (polyserine), A (polyacidic), and B (polybasic). We show that a β subunit containing only its A domain in the HOOK region increases inactivation kinetics and channel inhibition by PIP 2 depletion, whereas a β subunit with only a B domain decreases these responses. When both the A and B domains are deleted, or when the entire HOOK region is deleted, the responses are elevated. Using a peptide-to-liposome binding assay and confocal microscopy, we find that the B domain of the HOOK region directly interacts with anionic phospholipids via polybasic and two hydrophobic Phe residues. The β2c-short subunit, which lacks an A domain and contains fewer basic amino acids and no Phe residues in the B domain, neither associates with phospholipids nor affects channel gating dynamically. Together, our data suggest that the flexible HOOK region of the β subunit acts as an important regulator of Ca V channel gating via dynamic electrostatic and hydrophobic interaction with the plasma membrane. © 2017 Park et al.

  20. 14 CFR Appendix - Special Federal Aviation Regulation No. 14

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Special Federal Aviation Regulation No. 14 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... is power and/or thrust obtained from rocket engines for a relatively short period and actuated only...

  1. 14 CFR Appendix - Special Federal Aviation Regulation No. 14

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Special Federal Aviation Regulation No. 14 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... is power and/or thrust obtained from rocket engines for a relatively short period and actuated only...

  2. 75 FR 34634 - Special Local Regulation; Swim Across the Sound, Long Island Sound, Port Jefferson, NY to Captain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ...-AA08 Special Local Regulation; Swim Across the Sound, Long Island Sound, Port Jefferson, NY to Captain... Guard is establishing a permanent Special Local Regulation on the navigable waters of Long Island Sound... Sound event. This special local regulation is necessary to provide for the safety of life by protecting...

  3. Resident, State of Alaska

    Science.gov Websites

    Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees State of Alaska Search Home Quick Links Departments Commissioners Employee Whitepages State Government Jobs Federal Jobs Starting a Small Business Living Get a Driver License Get a Hunting

  4. Visitor, State of Alaska

    Science.gov Websites

    Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees State of Alaska Search Home Quick Links Departments Commissioners Employee Whitepages State Government Jobs Federal Jobs Starting a Small Business Living Get a Driver License Get a Hunting

  5. 24 CFR 598.515 - Alaska and Hawaii.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Alaska and Hawaii. 598.515 Section 598.515 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN...

  6. Equity in Fine Arts: A Training Module. Equity in Education. The Alaska Project.

    ERIC Educational Resources Information Center

    Alaska State Dept. of Education, Juneau. Office of Curriculum Services.

    Alaska's sex equity law, which prohibits sex discrimination in public school education, was passed by the Alaska legislature in 1981. Regulations require school districts to establish the training of personnel in the recognition of sex bias, and in the use of techniques and materials that may be used to overcome the effects of sex bias. This…

  7. 78 FR 19632 - Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ...-AA08 Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St... proposes to establish a special local regulation on the waters of Charlotte Amalie Harbor in St Thomas, USVI during the St. Thomas Carnival Watersport Activities, a high speed boat race. The event is...

  8. 78 FR 57063 - Special Local Regulations; Jacksonville Dragon Boat Festival; St. Johns River; Jacksonville, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... 1625-AA08 Special Local Regulations; Jacksonville Dragon Boat Festival; St. Johns River; Jacksonville... Special Local Regulation on the waters of the St. Johns River in Jacksonville, Florida during the... portion of the St. Johns River. Non-participant persons and vessels will be prohibited from entering or...

  9. 77 FR 39395 - Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...-AA08 Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI AGENCY... Tall Ships Festival 2012. DATES: This rule is effective from July 6, 2012 until July 10, 2012... ``Special Local Regulations: Ocean State Tall Ships Festival 2012, Narragansett Bay, RI'' in the Federal...

  10. 77 FR 9852 - Special Regulations; Areas of the National Park System, Cape Cod National Seashore

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... DEPARTMENT OF THE INTERIOR National Park Service 36 CFR Part 7 RIN 1024-AD88 Special Regulations; Areas of the National Park System, Cape Cod National Seashore AGENCY: National Park Service, Interior. ACTION: Final rule. SUMMARY: The National Park Service is amending special regulations for Cape Cod...

  11. 77 FR 72297 - Fisheries of the Exclusive Economic Zone Off Alaska; Gulf of Alaska; Proposed 2013 and 2014...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-05

    ... from http://www.regulations.gov or from the Alaska Region Web site at http://alaskafisheries.noaa.gov...) at 605 West 4th Avenue, Suite 306, Anchorage, AK 99501, phone 907-271-2809, or from the Council's Web... biomass trends for the following species are relatively stable: shallow-water flatfish, deep-water...

  12. 40 CFR 33.202 - How does an entity qualify as an MBE or WBE under EPA's 8% statute?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Indian tribes and Alaska Native Corporations; 13 CFR 124.110 for special rules applicable to Native... 124.103; see also 13 CFR 124.109 for special rules applicable to Indian tribes and Alaska Native... regulations (13 CFR 124.104). (See also 13 CFR 124.109 for special rules applicable to Indian tribes and...

  13. 49 CFR 234.255 - Gate arm and gate mechanism.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Gate arm and gate mechanism. 234.255 Section 234... Maintenance, Inspection, and Testing Inspections and Tests § 234.255 Gate arm and gate mechanism. (a) Each gate arm and gate mechanism shall be inspected at least once each month. (b) Gate arm movement shall be...

  14. 49 CFR 234.255 - Gate arm and gate mechanism.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Gate arm and gate mechanism. 234.255 Section 234... Maintenance, Inspection, and Testing Inspections and Tests § 234.255 Gate arm and gate mechanism. (a) Each gate arm and gate mechanism shall be inspected at least once each month. (b) Gate arm movement shall be...

  15. 49 CFR 234.255 - Gate arm and gate mechanism.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Gate arm and gate mechanism. 234.255 Section 234....255 Gate arm and gate mechanism. (a) Each gate arm and gate mechanism shall be inspected at least once each month. (b) Gate arm movement shall be observed for proper operation at least once each month. (c...

  16. 49 CFR 234.255 - Gate arm and gate mechanism.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Gate arm and gate mechanism. 234.255 Section 234....255 Gate arm and gate mechanism. (a) Each gate arm and gate mechanism shall be inspected at least once each month. (b) Gate arm movement shall be observed for proper operation at least once each month. (c...

  17. 49 CFR 234.255 - Gate arm and gate mechanism.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Gate arm and gate mechanism. 234.255 Section 234....255 Gate arm and gate mechanism. (a) Each gate arm and gate mechanism shall be inspected at least once each month. (b) Gate arm movement shall be observed for proper operation at least once each month. (c...

  18. 76 FR 56109 - Subsistence Management Regulations for Public Lands in Alaska-Subpart B, Federal Subsistence Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... questions specific to National Forest System lands, contact Steve Kessler, Subsistence Program Leader, USDA..., productivity, jobs, the environment, or other units of the government. (b) Whether the rule will create...; Jerry Berg, Alaska Regional Office, U.S. Fish and Wildlife Service; and Steve Kessler, Alaska Regional...

  19. Alaska Seismic Hazards Safety Commission

    Science.gov Websites

    State Employees ASHSC State of Alaska search Alaska Seismic Hazards Safety Commission View of Anchorage and Commissions Alaska Seismic Hazards Safety Commission (ASHSC) main contant Alaska Seismic Hazards Safety Commission logo Alaska Seismic Hazards Safety Commission (ASHSC) - Mission The Alaska Seismic

  20. Feedback circuit design of an auto-gating power supply for low-light-level image intensifier

    NASA Astrophysics Data System (ADS)

    Yang, Ye; Yan, Bo; Zhi, Qiang; Ni, Xiao-bing; Li, Jun-guo; Wang, Yu; Yao, Ze

    2015-11-01

    This paper introduces the basic principle of auto-gating power supply which using a hybrid automatic brightness control scheme. By the analysis of current as image intensifier to special requirements of auto-gating power supply, a feedback circuit of the auto-gating power supply is analyzed. Find out the reason of the screen flash after the auto-gating power supply assembled image intensifier. This paper designed a feedback circuit which can shorten the response time of auto-gating power supply and improve screen slight flicker phenomenon which the human eye can distinguish under the high intensity of illumination.

  1. 78 FR 21864 - Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... temporarily restrict vessel traffic in a portion of Breton Bay during the event. DATES: Comments and related...-AA08 Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD AGENCY... the waters of Breton Bay on July 13, 2013, and July 14, 2013. These special local regulations are...

  2. 78 FR 38001 - Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ...-AA08 Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD AGENCY... marine event to be held on the waters of Breton Bay in St. Mary's County, Maryland on July 13, 2013, and... ``Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD'' in the Federal...

  3. 77 FR 16974 - Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ...-AA08 Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI AGENCY... Island, for the Ocean State Tall Ships Festival 2012. This action is necessary to provide for the safety..., during the Ocean State Tall Ships Festival on July 6-9, 2012. These temporary special local regulations...

  4. 76 FR 7701 - Special Local Regulations; Krewe of Charleston Mardi Gras Boat Parade, Charleston Harbor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ...-AA08 Special Local Regulations; Krewe of Charleston Mardi Gras Boat Parade, Charleston Harbor... establishing a special local regulation for the Krewe of Charleston Mardi Gras Boat Parade on the Ashley River... Charleston Mardi Gras Boat Parade with sufficient time to publish an NPRM in advance of the effective date of...

  5. 78 FR 17087 - Special Local Regulation; New River Raft Race, New River; Fort Lauderdale, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ...-AA08 Special Local Regulation; New River Raft Race, New River; Fort Lauderdale, FL AGENCY: Coast Guard... Race, on Saturday, March 23, 2013. The special local regulation is necessary to ensure the safety of... contrary to the public interest because immediate action is needed to minimize potential danger to the race...

  6. Understanding the mechanism of proteasome 20S core particle gating

    PubMed Central

    Latham, Michael P.; Sekhar, Ashok; Kay, Lewis E.

    2014-01-01

    The 20S core particle proteasome is a molecular machine playing an important role in cellular function by degrading protein substrates that no longer are required or that have become damaged. Regulation of proteasome activity occurs, in part, through a gating mechanism controlling the sizes of pores at the top and bottom ends of the symmetric proteasome barrel and restricting access to catalytic sites sequestered in the lumen of the structure. Although atomic resolution models of both open and closed states of the proteasome have been elucidated, the mechanism by which gates exchange between these states remains to be understood. Here, this is investigated by using magnetization transfer NMR spectroscopy focusing on the 20S proteasome core particle from Thermoplasma acidophilum. We show from viscosity-dependent proteasome gating kinetics that frictional forces originating from random solvent motions are critical for driving the gating process. Notably, a small effective hydrodynamic radius (EHR; <4Å) is obtained, providing a picture in which gate exchange proceeds through many steps involving only very small segment sizes. A small EHR further suggests that the kinetics of gate interconversion will not be affected appreciably by large viscogens, such as macromolecules found in the cell, so long as they are inert. Indeed, measurements in cell lysate reveal that the gate interconversion rate decreases only slightly, demonstrating that controlled studies in vitro provide an excellent starting point for understanding regulation of 20S core particle function in complex, biologically relevant environments. PMID:24706783

  7. Emergence of ion channel modal gating from independent subunit kinetics.

    PubMed

    Bicknell, Brendan A; Goodhill, Geoffrey J

    2016-09-06

    Many ion channels exhibit a slow stochastic switching between distinct modes of gating activity. This feature of channel behavior has pronounced implications for the dynamics of ionic currents and the signaling pathways that they regulate. A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel, whose regulation of intracellular Ca(2+) concentration is essential for numerous cellular processes. However, the underlying biophysical mechanisms that give rise to modal gating in this and most other channels remain unknown. Although ion channels are composed of protein subunits, previous mathematical models of modal gating are coarse grained at the level of whole-channel states, limiting further dialogue between theory and experiment. Here we propose an origin for modal gating, by modeling the kinetics of ligand binding and conformational change in the IP3R at the subunit level. We find good agreement with experimental data over a wide range of ligand concentrations, accounting for equilibrium channel properties, transient responses to changing ligand conditions, and modal gating statistics. We show how this can be understood within a simple analytical framework and confirm our results with stochastic simulations. The model assumes that channel subunits are independent, demonstrating that cooperative binding or concerted conformational changes are not required for modal gating. Moreover, the model embodies a generally applicable principle: If a timescale separation exists in the kinetics of individual subunits, then modal gating can arise as an emergent property of channel behavior.

  8. Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease.

    PubMed

    Hull, Jacob M; Isom, Lori L

    2018-04-01

    Voltage gated sodium channels (VGSCs) were first identified in terms of their role in the upstroke of the action potential. The underlying proteins were later identified as saxitoxin and scorpion toxin receptors consisting of α and β subunits. We now know that VGSCs are heterotrimeric complexes consisting of a single pore forming α subunit joined by two β subunits; a noncovalently linked β1 or β3 and a covalently linked β2 or β4 subunit. VGSC α subunits contain all the machinery necessary for channel cell surface expression, ion conduction, voltage sensing, gating, and inactivation, in one central, polytopic, transmembrane protein. VGSC β subunits are more than simple accessories to α subunits. In the more than two decades since the original cloning of β1, our knowledge of their roles in physiology and pathophysiology has expanded immensely. VGSC β subunits are multifunctional. They confer unique gating mechanisms, regulate cellular excitability, affect brain development, confer distinct channel pharmacology, and have functions that are independent of the α subunits. The vast array of functions of these proteins stems from their special station in the channelome: being the only known constituents that are cell adhesion and intra/extracellular signaling molecules in addition to being part of channel complexes. This functional trifecta and how it goes awry demonstrates the power outside the pore in ion channel signaling complexes, broadening the term channelopathy beyond defects in ion conduction. This article is part of the Special Issue entitled 'Channelopathies.' Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Preventing deaths in Alaska's commercial fishing industry.

    PubMed

    Conway, G A; Lincoln, J M; Jorgensen, S A; Klatt, M L; Manwaring, J C

    1998-01-01

    The arctic and sub-arctic waters of Alaska provide a very hazardous work setting, with special hazards posed by great distances, seasonal darkness, cold waters, high winds, brief fishing seasons, and icing. Our intent is to reduce the remarkably high occupational fatality rate (200/100,000/year in 1991-1992) among Alaska's commercial fishing workers. Over 90% of these deaths have been due to drowning or drowning plus hypothermia, primarily associated with vessel capsizings and sinkings. Comprehensive surveillance for commercial fishing occupational fatalities was established during 1991 in Alaska. During 1990 through 1994, the U.S. Commercial Fishing Industry Vessel Safety Act of 1988 required the implementation of comprehensive prevention measures for all fishing vessels in offshore cold waters, including immersion suits and other personal flotation devices, survival craft (life rafts), emergency position-indicating radio beacons, and crew training in emergency response and first aid. Parallel to this, voluntary training efforts by nonprofit organizations have greatly increased. During 1990-1994, drowning was the leading cause of occupational death in Alaska. During this period, 117 fishers died, 101 of them from drowning or drowning/hypothermia. During 1991-1994, there was a substantial decrease in Alaskan commercial fishing-related deaths, from 34 in 1991 to 35 in 1992, 22 in 1993, and 10 in 1994. While man-overboard drownings and some other categories of deaths (falls, fires) have continued to occur, the most marked progress has been in vessel-related events. Specific measures tailored to prevent drowning in vessel capsizings and sinkings in Alaska's commercial fishing industry have been very successful so far. Additional efforts must be made to reduce the frequency of vessel events and to prevent man-overboard events and drownings associated with them.

  10. Alaska exceptionality hypothesis: Is Alaska wilderness really different?

    Treesearch

    Gregory Brown

    2002-01-01

    The common idiom of Alaska as “The Last Frontier” suggests that the relative remoteness and unsettled character of Alaska create a unique Alaskan identity, one that is both a “frontier” and the “last” of its kind. The frontier idiom portrays the place and people of Alaska as exceptional or different from the places and people who reside in the Lower Forty- Eight States...

  11. Erratum To: Indigenous Frameworks for Observing and Responding to Climate Change in Alaska

    NASA Technical Reports Server (NTRS)

    Cochran, Patricia; Huntington, Orville H.; Pungowiyi, Caleb; Tom, Stanley; Chapin, F. Stuart, III; Huntington, Henry P.; Maynard, Nancy G.; Trainor, Sarah F.

    2014-01-01

    In section 5, item 1 of this article it is stated that: A recent shift in decision-making authority from the politically appointed Board of Game to the Subsistence Division of the Alaska Department of Fish and Game should make these decisions about hunting regulations more responsive to local observations and needs. We now recognize that this shift in regulatory authority to ADF&G never occurred. We hereby correct this error so that wildlife users in Alaska do not come to ADF&G with expectations that this agency has authority to adjust hunting regulations to accommodate climate change.

  12. 14 CFR 91.1605 - Special Federal Aviation Regulation No. 77-Prohibition Against Certain Flights Within the...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Special Federal Aviation Regulation No. 77... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Special Federal Aviation Regulations...

  13. 14 CFR 91.1605 - Special Federal Aviation Regulation No. 77-Prohibition Against Certain Flights Within the...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Special Federal Aviation Regulation No. 77... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Special Federal Aviation Regulations...

  14. Alaska telemedicine: growth through collaboration.

    PubMed

    Patricoski, Chris

    2004-12-01

    The last thirty years have brought the introduction and expansion of telecommunications to rural and remote Alaska. The intellectual and financial investment of earlier projects, the more recent AFHCAN Project and the Universal Service Administrative Company Rural Health Care Division (RHCD) has sparked a new era in telemedicine and telecommunication across Alaska. This spark has been flamed by the dedication and collaboration of leaders at he highest levels of organizations such as: AFHCAN member organizations, AFHCAN Office, Alaska Clinical Engineering Services, Alaska Federal Health Care Partnership, Alaska Federal Health Care Partnership Office, Alaska Native health Board, Alaska Native Tribal health Consortium, Alaska Telehealth Advisory Council, AT&T Alascom, GCI Inc., Health care providers throughout the state of Alaska, Indian Health Service, U.S. Department of Health and Human Services, Office of U.S. Senator Ted Steens, State of Alaska, U.S. Department of Homeland Security--United States Coast Guard, United States Department of Agriculture, United States Department of Defense--Air Force and Army, United States Department of Veterans Affairs, University of Alaska, and University of Alaska Anchorage. Alaska now has one of the largest telemedicine programs in the world. As Alaska moves system now in place become self-sustaining, and 2) collaborating with all stakeholders in promoting the growth of an integrated, state-wide telemedicine network.

  15. 77 FR 65843 - Fisheries of the Exclusive Economic Zone Off Alaska; Revisions to IFQ Program Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... Bering Sea and Aleutian Islands Management Area, the Fishery Management Plan for Groundfish of the Gulf... D. The U.S. groundfish fisheries of the Gulf of Alaska (GOA) and the Bering Sea and Aleutian Islands... groundfish species under the FMP for Groundfish of the Gulf of Alaska. The fixed-gear sablefish fishery is...

  16. 78 FR 16780 - Special Local Regulation; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... 1625-AA08 Special Local Regulation; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U... is establishing special local regulations on the waters of St. Thomas Harbor in St. Thomas, U. S... changes to the regulation as originally proposed. On March 22, 2013, through March 24, 2013, the St...

  17. Spatial and temporal ecological variability in the northern Gulf of Alaska: What have we learned since the Exxon Valdez oil spill?

    NASA Astrophysics Data System (ADS)

    Aderhold, Donna G. R.; Lindeberg, Mandy R.; Holderied, Kris; Pegau, W. Scott

    2018-01-01

    This special issue examines oceanographic and biological variability in the northern Gulf of Alaska region with an emphasis on recent monitoring efforts of the Gulf Watch Alaska (GWA) and Herring Research and Monitoring (HRM) programs funded by the Exxon Valdez Oil Spill Trustee Council (EVOSTC). These programs are designed to improve our understanding of how changing environmental conditions affect Gulf of Alaska ecosystems and the long-term status of resources injured by the Exxon Valdez oil spill.

  18. 36 CFR 223.201 - Limitations on unprocessed timber harvested in Alaska.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Limitations on unprocessed timber harvested in Alaska. 223.201 Section 223.201 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND...

  19. 78 FR 53137 - Flint Hills Resources Alaska, LLC, BP Pipelines (Alaska) Inc., ConocoPhillips Transportation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. OR13-31-000] Flint Hills Resources Alaska, LLC, BP Pipelines (Alaska) Inc., ConocoPhillips Transportation Alaska, Inc., ExxonMobil... (Alaska) Inc., ConocoPhillips Transportation Alaska, Inc., and ExxonMobil Pipeline Company (collectively...

  20. Quantum gates by periodic driving

    PubMed Central

    Shi, Z. C.; Wang, W.; Yi, X. X.

    2016-01-01

    Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions—it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work, we present a method to realize single qubit quantum gates by periodic driving. Compared to adiabatic evolution, the single qubit gates can be realized at a fixed time much shorter than that by adiabatic evolution. The driving fields can be sinusoidal or square-well field. With the sinusoidal driving field, we derive an expression for the total operation time in the high-frequency limit, and an exact analytical expression for the evolution operator without any approximations is given for the square well driving. This study suggests that the period driving could provide us with a new direction in regulations of the operation time in topological quantum computation. PMID:26911900

  1. Quantum gates by periodic driving.

    PubMed

    Shi, Z C; Wang, W; Yi, X X

    2016-02-25

    Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions-it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work, we present a method to realize single qubit quantum gates by periodic driving. Compared to adiabatic evolution, the single qubit gates can be realized at a fixed time much shorter than that by adiabatic evolution. The driving fields can be sinusoidal or square-well field. With the sinusoidal driving field, we derive an expression for the total operation time in the high-frequency limit, and an exact analytical expression for the evolution operator without any approximations is given for the square well driving. This study suggests that the period driving could provide us with a new direction in regulations of the operation time in topological quantum computation.

  2. 78 FR 24063 - Special Local Regulation; Hebda Cup Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ...-AA08 Special Local Regulation; Hebda Cup Rowing Regatta, Trenton Channel; Detroit River, Wyandotte, MI..., during, and immediately after the Hebda Cup Rowing Regatta. This special local regulation will establish... this boat race. It is also unnecessary to solicit public comments because the Hebda Cup Rowing Regatta...

  3. 78 FR 59230 - Special Local Regulations; Annual Marine Events on the Colorado River, Between Davis Dam...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket No. USCG-2013-0644] Special Local Regulations; Annual Marine Events on the Colorado River, Between Davis Dam (Bullhead City, Arizona... INFORMATION: The Coast Guard will enforce the special local regulations on the Colorado River for the...

  4. 78 FR 28492 - Special Local Regulation; Low Country Splash, Wando River, Cooper River, and Charleston Harbor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... to the local maritime community via broadcast notice to mariners. 2. Impact on Small Entities Under...-AA08 Special Local Regulation; Low Country Splash, Wando River, Cooper River, and Charleston Harbor... establishing a special local regulation on the waters of the Wando River, Cooper River, and Charleston Harbor...

  5. 78 FR 38577 - Special Local Regulations; Red Bull Flugtag National Harbor Event, Potomac River; National Harbor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ...-AA08 Special Local Regulations; Red Bull Flugtag National Harbor Event, Potomac River; National Harbor... waters of the Potomac River on September 21, 2013. These special local regulations are necessary to... temporarily restrict vessel traffic in a portion of the Potomac River during the event. DATES: This rule is...

  6. Alaska Energy Inventory Project: Consolidating Alaska's Energy Resources

    NASA Astrophysics Data System (ADS)

    Papp, K.; Clough, J.; Swenson, R.; Crimp, P.; Hanson, D.; Parker, P.

    2007-12-01

    Alaska has considerable energy resources distributed throughout the state including conventional oil, gas, and coal, and unconventional coalbed and shalebed methane, gas hydrates, geothermal, wind, hydro, and biomass. While much of the known large oil and gas resources are concentrated on the North Slope and in the Cook Inlet regions, the other potential sources of energy are dispersed across a varied landscape from frozen tundra to coastal settings. Despite the presence of these potential energy sources, rural Alaska is mostly dependent upon diesel fuel for both electrical power generation and space heating needs. At considerable cost, large quantities of diesel fuel are transported to more than 150 roadless communities by barge or airplane and stored in large bulk fuel tank farms for winter months when electricity and heat are at peak demands. Recent increases in the price of oil have severely impacted the price of energy throughout Alaska, and especially hard hit are rural communities and remote mines that are off the road system and isolated from integrated electrical power grids. Even though the state has significant conventional gas resources in restricted areas, few communities are located near enough to these resources to directly use natural gas to meet their energy needs. To address this problem, the Alaska Energy Inventory project will (1) inventory and compile all available Alaska energy resource data suitable for electrical power generation and space heating needs including natural gas, coal, coalbed and shalebed methane, gas hydrates, geothermal, wind, hydro, and biomass and (2) identify locations or regions where the most economic energy resource or combination of energy resources can be developed to meet local needs. This data will be accessible through a user-friendly web-based interactive map, based on the Alaska Department of Natural Resources, Land Records Information Section's (LRIS) Alaska Mapper, Google Earth, and Terrago Technologies' Geo

  7. Geologic framework of the Alaska Peninsula, southwest Alaska, and the Alaska Peninsula terrane

    USGS Publications Warehouse

    Wilson, Frederic H.; Detterman, Robert L.; DuBois, Gregory D.

    2015-01-01

    The boundaries separating the Alaska Peninsula terrane from other terranes are commonly indistinct or poorly defined. A few boundaries have been defined at major faults, although the extensions of these faults are speculative through some areas. The west side of the Alaska Peninsula terrane is overlapped by Tertiary sedimentary and volcanic rocks and Quaternary deposits.

  8. 76 FR 57645 - Special Local Regulations for Marine Events; Temporary Change of Dates for Recurring Marine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket No. USCG-2011-0629] RIN 1625-AA08 Special Local Regulations for Marine Events; Temporary Change of Dates for Recurring Marine Events... made: Sec. 100.501 Special Local Regulations; Marine Events in the Fifth Coast Guard District. 0 1. On...

  9. 33 CFR 100.1309 - Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. 100.1309 Section 100.1309 Navigation and Navigable Waters... WATERS § 100.1309 Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. (a...

  10. 33 CFR 100.1309 - Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. 100.1309 Section 100.1309 Navigation and Navigable Waters... WATERS § 100.1309 Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. (a...

  11. 33 CFR 100.1309 - Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. 100.1309 Section 100.1309 Navigation and Navigable Waters... WATERS § 100.1309 Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. (a...

  12. 33 CFR 100.1309 - Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. 100.1309 Section 100.1309 Navigation and Navigable Waters... WATERS § 100.1309 Special Local Regulation; Olympia Harbor Days Tug Boat Races, Budd Inlet, WA. (a...

  13. 77 FR 19570 - Special Local Regulation for Marine Events, Chesapeake Bay Workboat Race, Back River, Messick...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ...-AA08 Special Local Regulation for Marine Events, Chesapeake Bay Workboat Race, Back River, Messick... Guard proposes to establish a special local regulation during the Chesapeake Bay Workboat Race, a series of boat races to be held on the waters of Back River, Poquoson, Virginia on June 24, 2012. This event...

  14. Complete all-optical processing polarization-based binary logic gates and optical processors.

    PubMed

    Zaghloul, Y A; Zaghloul, A R M

    2006-10-16

    We present a complete all-optical-processing polarization-based binary-logic system, by which any logic gate or processor can be implemented. Following the new polarization-based logic presented in [Opt. Express 14, 7253 (2006)], we develop a new parallel processing technique that allows for the creation of all-optical-processing gates that produce a unique output either logic 1 or 0 only once in a truth table, and those that do not. This representation allows for the implementation of simple unforced OR, AND, XOR, XNOR, inverter, and more importantly NAND and NOR gates that can be used independently to represent any Boolean expression or function. In addition, the concept of a generalized gate is presented which opens the door for reconfigurable optical processors and programmable optical logic gates. Furthermore, the new design is completely compatible with the old one presented in [Opt. Express 14, 7253 (2006)], and with current semiconductor based devices. The gates can be cascaded, where the information is always on the laser beam. The polarization of the beam, and not its intensity, carries the information. The new methodology allows for the creation of multiple-input-multiple-output processors that implement, by itself, any Boolean function, such as specialized or non-specialized microprocessors. Three all-optical architectures are presented: orthoparallel optical logic architecture for all known and unknown binary gates, singlebranch architecture for only XOR and XNOR gates, and the railroad (RR) architecture for polarization optical processors (POP). All the control inputs are applied simultaneously leading to a single time lag which leads to a very-fast and glitch-immune POP. A simple and easy-to-follow step-by-step algorithm is provided for the POP, and design reduction methodologies are briefly discussed. The algorithm lends itself systematically to software programming and computer-assisted design. As examples, designs of all binary gates, multiple

  15. Biophysics of BK Channel Gating.

    PubMed

    Pantazis, A; Olcese, R

    2016-01-01

    BK channels are universal regulators of cell excitability, given their exceptional unitary conductance selective for K(+), joint activation mechanism by membrane depolarization and intracellular [Ca(2+)] elevation, and broad expression pattern. In this chapter, we discuss the structural basis and operational principles of their activation, or gating, by membrane potential and calcium. We also discuss how the two activation mechanisms interact to culminate in channel opening. As members of the voltage-gated potassium channel superfamily, BK channels are discussed in the context of archetypal family members, in terms of similarities that help us understand their function, but also seminal structural and biophysical differences that confer unique functional properties. © 2016 Elsevier Inc. All rights reserved.

  16. Polar bear management in Alaska 1997-2000

    USGS Publications Warehouse

    Schliebe, Scott L.; Bridges, John W.; Evans, Thomas J.; Fischbach, Anthony S.; Kalxdorff, Susanne B.; Lierheimer, Lisa J.; Lunn, Nicholas J.; Schliebe, Scott L.; Born, Erik W.; Lunn, Nicholas J.; Schliebe, Scott L.; Born, Erik W.

    2002-01-01

    Since the Twelfth Working Meeting of the IUCN/SSC Polar Bear Specialist Group in 1997, a number of changes in the management of polar bears have occurred in Alaska. On October 16, 2000, the governments of the United States and the Russian Federation signed the “Agreement on the Conservation and Management of the Alaska-Chukotka Polar Bear Population.” This agreement provides substantial benefits for the effective conservation of polar bears shared between the U.S. and Russia. It will require enactment of enabling legislation by the U.S. Congress and other steps by Russia before the agreement has the force of law. A copy of the agreement is included as Appendix 1 to this report. Also, during this period, regulations were developed to implement 1994 amendments to the Marine Mammal Protection Act (MMPA), which allow polar bear trophies taken in approved Canadian populations by U.S. citizens to be imported into the U.S. A summary of the regulatory actions and a table listing populations approved for importation and the number of polar bears imported into the U.S. since 1997 is included in this report. Regarding oil and gas activities in polar bear habitat, three sets of regulations were published authorizing the incidental, non-intentional, taking of small numbers of polar bears concurrent to oil and gas activities.Cooperation continued with the Alaska Nanuuq Commission, representing the polar bear hunting communities in Alaska, as well as with the North Slope Borough and the Inuvialuit Game Council in their agreement for the management of the Southern Beaufort Sea polar bear population. Harvest summaries and technical assistance in designing and assistance in conducting a National Park Service/Alaska Nanuuq Commission study to collect traditional ecological knowledge of polar bear habitat use in Chukotka were provided. In addition, a long-range plan was developed to address and minimize polar bear-human conflicts in North Slope communities.We continued to monitor

  17. CNG channel subunit glycosylation regulates MMP-dependent changes in channel gating

    PubMed Central

    Meighan, Starla E.; Meighan, Peter C.; Rich, Elizabeth D.; Brown, R. Lane; Varnum, Michael D.

    2013-01-01

    Cyclic-nucleotide gated (CNG) channels are essential for phototransduction within retinal photoreceptors. We have demonstrated previously that enzymatic activity of matrix metalloproteinase-2 and -9, members of the MMP family of extracellular, Ca+2- and Zn+2-dependent proteases, enhances the ligand sensitivity of both rod (CNGA1 + CNGB1) and cone CNGA3 + CNGB3) CNG channels. Additionally, we have observed a decrease in maximal CNG channel current (IMAX) that begins late during MMP-directed gating changes. Here we demonstrate that CNG channels become non-conductive after prolonged MMP exposure. Concurrent with the loss of conductive channels is the increased relative contribution of channels exhibiting non-modified gating properties, suggesting the presence of a subpopulation of channels that are protected from MMP-induced gating effects. CNGA subunits are known to possess one extracellular core glycosylation site, located at one of two possible positions within the turret loop near the pore-forming region. Our results indicate that CNGA glycosylation can impede MMP-dependent modification of CNG channels. Furthermore, the relative position of the glycosylation site within the pore turret influences the extent of MMP-dependent proteolysis. Glycosylation at the site found in CNGA3 subunits was found to be protective, while glycosylation at the bovine CNGA1 site was not. Relocating the glycosylation site in CNGA1 to the position found in CNGA3 recapitulated CNGA3-like protection from MMP-dependent processing. Taken together, these data indicate that CNGA glycosylation may protect CNG channels from MMP-dependent proteolysis, consistent with MMP modification of channel function having a requirement for physical access to the extracellular face of the channel. PMID:24164424

  18. The NH2 terminus regulates voltage-dependent gating of CALHM ion channels.

    PubMed

    Tanis, Jessica E; Ma, Zhongming; Foskett, J Kevin

    2017-08-01

    Calcium homeostasis modulator protein-1 (CALHM1) and its Caenorhabditis elegans (ce) homolog, CLHM-1, belong to a new family of physiologically important ion channels that are regulated by voltage and extracellular Ca 2+ (Ca 2+ o ) but lack a canonical voltage-sensing domain. Consequently, the intrinsic voltage-dependent gating mechanisms for CALHM channels are unknown. Here, we performed voltage-clamp experiments on ceCLHM-1 chimeric, deletion, insertion, and point mutants to assess the role of the NH 2 terminus (NT) in CALHM channel gating. Analyses of chimeric channels in which the ceCLHM-1 and human (h)CALHM1 NH 2 termini were interchanged showed that the hCALHM1 NT destabilized channel-closed states, whereas the ceCLHM-1 NT had a stabilizing effect. In the absence of Ca 2+ o , deletion of up to eight amino acids from the ceCLHM-1 NT caused a hyperpolarizing shift in the conductance-voltage relationship with little effect on voltage-dependent slope. However, deletion of nine or more amino acids decreased voltage dependence and induced a residual conductance at hyperpolarized voltages. Insertion of amino acids into the NH 2 -terminal helix also decreased voltage dependence but did not prevent channel closure. Mutation of ceCLHM-1 valine 9 and glutamine 13 altered half-maximal activation and voltage dependence, respectively, in 0 Ca 2+ In 2 mM Ca 2+ o , ceCLHM-1 NH 2 -terminal deletion and point mutant channels closed completely at hyperpolarized voltages with apparent affinity for Ca 2+ o indistinguishable from wild-type ceCLHM-1, although the ceCLHM-1 valine 9 mutant exhibited an altered conductance-voltage relationship and kinetics. We conclude that the NT plays critical roles modulating voltage dependence and stabilizing the closed states of CALHM channels. Copyright © 2017 the American Physiological Society.

  19. 77 FR 39453 - Special Local Regulations for Marine Events; Temporary Change of Dates for Recurring Marine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...--AA08 Special Local Regulations for Marine Events; Temporary Change of Dates for Recurring Marine Events... change of the enforcement period for a special local regulation of a recurring marine event in the Fifth... rulemaking will be initiated on this matter; rather, the event will be held as detailed in the existing...

  20. 33 CFR 100.728 - Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; Hurricane Offshore Classic, St. Petersburg, FL. 100.728 Section 100.728 Navigation and Navigable Waters... WATERS § 100.728 Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL. (a) Regulated... commander designated by Coast Guard Sector St. Petersburg, Florida. (2) Spectator craft will be permitted...

  1. 100-nm gate lithography for double-gate transistors

    NASA Astrophysics Data System (ADS)

    Krasnoperova, Azalia A.; Zhang, Ying; Babich, Inna V.; Treichler, John; Yoon, Jung H.; Guarini, Kathryn; Solomon, Paul M.

    2001-09-01

    The double gate field effect transistor (FET) is an exploratory device that promises certain performance advantages compared to traditional CMOS FETs. It can be scaled down further than the traditional devices because of the greater electrostatic control by the gates on the channel (about twice as short a channel length for the same gate oxide thickness), has steeper sub-threshold slope and about double the current for the same width. This paper presents lithographic results for double gate FET's developed at IBM's T. J. Watson Research Center. The device is built on bonded wafers with top and bottom gates self-aligned to each other. The channel is sandwiched between the top and bottom polysilicon gates and the gate length is defined using DUV lithography. An alternating phase shift mask was used to pattern gates with critical dimensions of 75 nm, 100 nm and 125 nm in photoresist. 50 nm gates in photoresist have also been patterned by 20% over-exposure of nominal 100 nm lines. No trim mask was needed because of a specific way the device was laid out. UV110 photoresist from Shipley on AR-3 antireflective layer were used. Process windows, developed and etched patterns are presented.

  2. Alaska GeoFORCE, A New Geologic Adventure in Alaska

    NASA Astrophysics Data System (ADS)

    Wartes, D.

    2011-12-01

    RAHI, the Rural Alaska Honors Institute is a statewide, six-week, summer college-preparatory bridge program at the University of Alaska Fairbanks for Alaska Native and rural high school juniors and seniors. A program of rigorous academic activity combines with social, cultural, and recreational activities. Students are purposely stretched beyond their comfort levels academically and socially to prepare for the big step from home or village to a large culturally western urban campus. This summer RAHI is launching a new program, GeoFORCE Alaska. This outreach initiative is designed to increase the number and diversity of students pursuing STEM degree programs and entering the future high-tech workforce. It uses Earth science as the hook because most kids get excited about dinosaurs, volcanoes and earthquakes, but it includes physics, chemistry, math, biology and other sciences. Students will be recruited, initially from the Arctic North Slope schools, in the 8th grade to begin the annual program of approximately 8 days, the summer before their 9th grade year and then remain in the program for all four years of high school. They must maintain a B or better grade average and participate in all GeoFORCE events. The carrot on the end of the stick is an exciting field event each summer. Over the four-year period, events will include trips to Fairbanks, Arizona, Oregon and the Appalachians. All trips are focused on Earth science and include a 100+ page guidebook, with tests every night culminating with a final exam. GeoFORCE Alaska is being launched by UAF in partnership with the University of Texas at Austin, which has had tremendous success with GeoFORCE Texas. GeoFORCE Alaska will be managed by UAF's long-standing Rural Alaska Honors Insitute (RAHI) that has been successfully providing intense STEM educational opportunities for Alaskan high school students for almost 30 years. The Texas program, with adjustments for differences in culture and environment, will be

  3. Voltage Gated Ion Channel Function: Gating, Conduction, and the Role of Water and Protons

    PubMed Central

    Kariev, Alisher M.; Green, Michael E.

    2012-01-01

    Ion channels, which are found in every biological cell, regulate the concentration of electrolytes, and are responsible for multiple biological functions, including in particular the propagation of nerve impulses. The channels with the latter function are gated (opened) by a voltage signal, which allows Na+ into the cell and K+ out. These channels have several positively charged amino acids on a transmembrane domain of their voltage sensor, and it is generally considered, based primarily on two lines of experimental evidence, that these charges move with respect to the membrane to open the channel. At least three forms of motion, with greatly differing extents and mechanisms of motion, have been proposed. There is a “gating current”, a capacitative current preceding the channel opening, that corresponds to several charges (for one class of channel typically 12–13) crossing the membrane field, which may not require protein physically crossing a large fraction of the membrane. The coupling to the opening of the channel would in these models depend on the motion. The conduction itself is usually assumed to require the “gate” of the channel to be pulled apart to allow ions to enter as a section of the protein partially crosses the membrane, and a selectivity filter at the opposite end of the channel determines the ion which is allowed to pass through. We will here primarily consider K+ channels, although Na+ channels are similar. We propose that the mechanism of gating differs from that which is generally accepted, in that the positively charged residues need not move (there may be some motion, but not as gating current). Instead, protons may constitute the gating current, causing the gate to open; opening consists of only increasing the diameter at the gate from approximately 6 Å to approximately 12 Å. We propose in addition that the gate oscillates rather than simply opens, and the ion experiences a barrier to its motion across the channel that is tuned

  4. 76 FR 70342 - Quarterly Listings; Safety Zones, Security Zones, Special Local Regulations, Drawbridge Operation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ...] Quarterly Listings; Safety Zones, Security Zones, Special Local Regulations, Drawbridge Operation... published in the Federal Register. This notice lists temporary safety zones, security zones, special local..., telephone (202) 372-3862. For questions on viewing, or on submitting material to the docket, contact Ms...

  5. A Secondary Structural Transition in the C-helix Promotes Gating of Cyclic Nucleotide-regulated Ion Channels*

    PubMed Central

    Puljung, Michael C.; Zagotta, William N.

    2013-01-01

    Cyclic nucleotide-regulated ion channels bind second messengers like cAMP to a C-terminal domain, consisting of a β-roll, followed by two α-helices (B- and C-helices). We monitored the cAMP-dependent changes in the structure of the C-helix of a C-terminal fragment of HCN2 channels using transition metal ion FRET between fluorophores on the C-helix and metal ions bound between histidine pairs on the same helix. cAMP induced a change in the dimensions of the C-helix and an increase in the metal binding affinity of the histidine pair. cAMP also caused an increase in the distance between a fluorophore on the C-helix and metal ions bound to the B-helix. Stabilizing the C-helix of intact CNGA1 channels by metal binding to a pair of histidines promoted channel opening. These data suggest that ordering of the C-helix is part of the gating conformational change in cyclic nucleotide-regulated channels. PMID:23525108

  6. Chronic conditions, functional difficulties, and disease burden among American Indian/Alaska Native children with special health care needs, 2009-2010.

    PubMed

    Kenney, Mary Kay; Thierry, Judy

    2014-11-01

    The purpose of this study was to determine the prevalence of chronic conditions and functional difficulties of American Indian/Alaska Native (AIAN) children with special health care needs (CSHCN). We conducted bivariate and multivariable analysis of cross-sectional data on 40,202 children from the 2009-2010 National Survey of Children with Special Health Care Needs aged birth through 17 years, including 1,051 AIAN CSHCN. The prevalence of AIAN CSHCN was 15.7 %, not significantly different from the prevalence of US white CSHCN (16.3 %). As qualifiers for special needs status among AIAN children the use of or need for prescription medication was the most frequent (70 %), compared to the lower rates of need for elevated service use (44 %) and emotional, mental, or behavioral treatment/counseling (36 %). Asthma (45 %), conduct disorder (18 %), developmental delay (27 %), and migraine headaches (16 %) were significantly more common chronic conditions among AIAN CSHCN compared to white CSHCN, as were functional difficulties with respiration (52 %), communication (42 %), anxiety/depression (57 %), and behavior (54 %). AIAN CSHCN were also more likely to have 3 or more chronic conditions (39 vs. 28 %, respectively) and 3 or more functional difficulties (70 vs. 55 %, respectively) than white CSHCN. Results indicated a greater impact on the daily activities of AIAN CSHCN compared to white CSHCN (74 vs. 63 %). Significantly greater disease burden among AIAN CSHCN suggests that care must be taken to ensure an appropriate level of coordinated care in a medical home to ameliorate the severity and complexity of their conditions.

  7. Diverse Roles for Auxiliary Subunits in Phosphorylation-Dependent Regulation of Mammalian Brain Voltage-Gated Potassium Channels

    PubMed Central

    Vacher, Helene; Trimmer, James S.

    2012-01-01

    Voltage-gated ion channels are a diverse family of signaling proteins that mediate rapid electrical signaling events. Among these, voltage-gated potassium or Kv channels are the most diverse, in part due to the large number of principal (or α) subunits and auxiliary subunits that can assemble in different combinations to generate Kv channel complexes with distinct structures and functions. The diversity of Kv channels underlies much of the variability in the active properties between different mammalian central neurons, and the dynamic changes that lead to experience-dependent plasticity in intrinsic excitability. Recent studies have revealed that Kv channel α subunits and auxiliary subunits are extensively phosphorylated, contributing to additional structural and functional diversity. Here we highlight recent studies that show that auxiliary subunits exert some of their profound effects on dendritic Kv4 and axonal Kv1 channels through phosphorylation-dependent mechanisms, either due to phosphorylation on the auxiliary subunit itself, or by influencing the extent and/or impact of α subunit phosphorylation. The complex effects of auxiliary subunits and phosphorylation provide a potent mechanism to generate additional diversity in the structure and function of Kv4 and Kv1 channels, as well as allowing for dynamic reversible regulation of these important ion channels. PMID:21822597

  8. 77 FR 23120 - Special Local Regulations; Lowcountry Splash Open Water Swim, Wando River and Cooper River, Mount...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ...-AA08 Special Local Regulations; Lowcountry Splash Open Water Swim, Wando River and Cooper River, Mount... at Patriots Point on the Cooper River. Approximately 600 swimmers will be participating in the swim... Special Local Regulations; Lowcountry Splash Open Water Swim, Wando River and Cooper River, Mount Pleasant...

  9. Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate

    PubMed Central

    Lin, Wen-Ying; Sohma, Yoshiro

    2016-01-01

    Cystic fibrosis (CF) is caused by loss-of-function mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene encoding a phosphorylation-activated but ATP-gated chloride channel. Previous studies suggested that VX-770 [ivacaftor, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide], a CFTR potentiator now used in clinics, increases the open probability of CFTR by shifting the gating conformational changes to favor the open channel configuration. Recently the chloride channel blocker and CFTR potentiator 5-nitro-2-(3-phenylpropylamino) benzoate (NPPB) has been reported to enhance CFTR activity by a mechanism that exploits the ATP hydrolysis-driven, nonequilibrium gating mechanism unique to CFTR. Surprisingly however, NPPB increased the activity of nonhydrolytic G551D-CFTR, the third most common disease-associated mutation. Here, we further investigated the mechanism of NPPB’s effects on CFTR gating by assessing its interaction with well-studied VX-770. Interestingly, once G551D-CFTR was maximally potentiated by VX-770, NPPB further increased its activity. However, quantitative analysis of this drug–drug interaction suggests that this pharmacologic synergism is not due to independent actions of NPPB and VX-770 on CFTR gating; instead, our data support a dependent mechanism involving two distinct binding sites. This latter idea is further supported by the observation that the locked-open time of a hydrolysis-deficient mutant K1250A was shortened by NPPB but prolonged by VX-770. In addition, the effectiveness of NPPB, but not of VX-770, was greatly diminished in a mutant whose second nucleotide-binding domain was completely removed. Interpreting these results under the framework of current understanding of CFTR gating not only reveals insights into the mechanism of action for different CFTR potentiators but also brings us one step forward to a more complete schematic for CFTR gating. PMID:27413118

  10. Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology.

    PubMed

    Wang, Baojun; Kitney, Richard I; Joly, Nicolas; Buck, Martin

    2011-10-18

    Modular and orthogonal genetic logic gates are essential for building robust biologically based digital devices to customize cell signalling in synthetic biology. Here we constructed an orthogonal AND gate in Escherichia coli using a novel hetero-regulation module from Pseudomonas syringae. The device comprises two co-activating genes hrpR and hrpS controlled by separate promoter inputs, and a σ(54)-dependent hrpL promoter driving the output. The hrpL promoter is activated only when both genes are expressed, generating digital-like AND integration behaviour. The AND gate is demonstrated to be modular by applying new regulated promoters to the inputs, and connecting the output to a NOT gate module to produce a combinatorial NAND gate. The circuits were assembled using a parts-based engineering approach of quantitative characterization, modelling, followed by construction and testing. The results show that new genetic logic devices can be engineered predictably from novel native orthogonal biological control elements using quantitatively in-context characterized parts. © 2011 Macmillan Publishers Limited. All rights reserved.

  11. Retaining Quality Teachers for Alaska.

    ERIC Educational Resources Information Center

    McDiarmid, G. Williamson; Larson, Eric; Hill, Alexandra

    This report examines the demand for teachers, teacher turnover, and teacher education in Alaska. Surveys were conducted with school district personnel directors, directors of Alaska teacher education programs, teachers who exited Alaska schools in 2001, and rural and urban instructional aides. Alaska is facing teacher shortages, but these are…

  12. Fisheries Education in Alaska. Conference Report. Alaska Sea Grant Report 82-4.

    ERIC Educational Resources Information Center

    Smoker, William W., Ed.

    This conference was an attempt to have the fishing industry join the state of Alaska in building fisheries education programs. Topics addressed in papers presented at the conference include: (1) fisheries as a part of life in Alaska, addressing participation of Alaska natives in commercial fisheries and national efforts; (2) the international…

  13. 33 CFR 100.T01-0103 - Special Local Regulation; Extreme Sailing Series Boston; Boston Harbor; Boston, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Sailing Series Boston; Boston Harbor; Boston, MA. 100.T01-0103 Section 100.T01-0103 Navigation and... NAVIGABLE WATERS § 100.T01-0103 Special Local Regulation; Extreme Sailing Series Boston; Boston Harbor... special local regulation area is designed to restrict vessel traffic, including all non-motorized vessels...

  14. 75 FR 24799 - Special Local Regulation for Marine Events; Temporary Change of Dates for Recurring Marine Events...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ...-AA08 Special Local Regulation for Marine Events; Temporary Change of Dates for Recurring Marine Events... period of two special local regulations for recurring marine events in the Fifth Coast Guard District... errors do not impact the events scheduled for this year, but could cause confusion about future years...

  15. Facile fabrication of highly controllable gating systems based on the combination of inverse opal structure and dynamic covalent chemistry.

    PubMed

    Wang, Chen; Yang, Haowei; Tian, Li; Wang, Shiqiang; Gao, Ning; Zhang, Wanlin; Wang, Peng; Yin, Xianpeng; Li, Guangtao

    2017-06-01

    A three-dimensional (3D) inverse opal with periodic and porous structures has shown great potential for applications not only in optics and optoelectronics, but also in functional membranes. In this work, the benzaldehyde group was initially introduced into a 3D nanoporous inverse opal, serving as a platform for fabricating functional membranes. By employing the dynamic covalent approach, a highly controllable gating system was facilely fabricated to achieve modulable and reversible transport features. It was found that the physical/chemical properties and pore size of the gating system could easily be regulated through post-modification with amines. As a demonstration, the gated nanopores were modified with three kinds of amines to control the wettability, surface charge and nanopore size which in turn was exploited to achieve selective mass transport, including hydrophobic molecules, cations and anions, and the transport with respect to the physical steric hindrance. In particular, the gating system showed extraordinary reversibility and could recover to its pristine state by simply changing pH values. Due to the unlimited variety provided by the Schiff base reaction, the inverse opal described here exhibits a significant extendibility and could be easily post-modified with stimuli-responsive molecules for special purposes. Furthermore, this work can be extended to employ other dynamic covalent routes, for example Diels-Alder, ester exchange and disulfide exchange-based routes.

  16. 76 FR 37274 - Outer Continental Shelf Air Regulations Consistency Update for Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... and prevents EPA from making substantive changes to the requirements it incorporates. As a result, EPA... narrative discussing how EPA made the decision to include or exclude rules. The Alaska Eskimo Whaling Commission expressed specific concern with EPA's decision to exclude administrative and procedural rules and...

  17. 78 FR 34881 - Special Local Regulations; Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ...-AA08 Special Local Regulations; Marine Events, Wrightsville Channel; Wrightsville Beach, NC AGENCY... Regulation for the ``Swim the Loop/Motts Channel Sprint'' swim event, to be held on the waters adjacent to... necessary to provide for the safety of life on navigable waters during the event. This action will restrict...

  18. 33 CFR 100.728 - Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...; Hurricane Offshore Classic, St. Petersburg, FL. 100.728 Section 100.728 Navigation and Navigable Waters... WATERS § 100.728 Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL. (a) Regulated..., from 10 a.m. to 6 p.m. EDT. (3) All vessel traffic, not involved in the Hurricane Offshore Classic...

  19. 33 CFR 100.728 - Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...; Hurricane Offshore Classic, St. Petersburg, FL. 100.728 Section 100.728 Navigation and Navigable Waters... WATERS § 100.728 Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL. (a) Regulated..., from 10 a.m. to 6 p.m. EDT. (3) All vessel traffic, not involved in the Hurricane Offshore Classic...

  20. 33 CFR 100.728 - Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...; Hurricane Offshore Classic, St. Petersburg, FL. 100.728 Section 100.728 Navigation and Navigable Waters... WATERS § 100.728 Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL. (a) Regulated..., from 10 a.m. to 6 p.m. EDT. (3) All vessel traffic, not involved in the Hurricane Offshore Classic...

  1. 76 FR 8651 - Special Local Regulation; Mavericks Surf Competition, Half Moon Bay, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ...-AA08 Special Local Regulation; Mavericks Surf Competition, Half Moon Bay, CA AGENCY: Coast Guard, DHS... regulation on certain navigable waters of Half Moon Bay in support of the Mavericks Surf Competition. This...,000 yard radius of Pillar Point in Half Moon Bay. The Mavericks Surf Competition will occur in the...

  2. 33 CFR 100.728 - Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...; Hurricane Offshore Classic, St. Petersburg, FL. 100.728 Section 100.728 Navigation and Navigable Waters... WATERS § 100.728 Special Local Regulations; Hurricane Offshore Classic, St. Petersburg, FL. (a) Regulated..., from 10 a.m. to 6 p.m. EDT. (3) All vessel traffic, not involved in the Hurricane Offshore Classic...

  3. 78 FR 38829 - Special Local Regulations; Seattle Seafair Hydroplane Race, Lake Washington, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... Local Regulations; Seattle Seafair Hydroplane Race, Lake Washington, WA AGENCY: Coast Guard, DHS. ACTION... Hydroplane Race Special Local Regulation on Lake Washington, WA from 8 a.m. on August 2, 2013, through 11:59... restrict general navigation in the following area; The waters of Lake Washington bounded by the Interstate...

  4. Alaska Mental Health Board

    Science.gov Websites

    State Employees Alaska Mental Health Board DHSS State of Alaska Home Divisions and Agencies Alaska Pioneer Homes Behavioral Health Office of Children's Services Office of the Commissioner Office of Substance Misuse and Addiction Prevention Finance & Management Services Health Care Services Juvenile

  5. Publications - STATEMAP Project | Alaska Division of Geological &

    Science.gov Websites

    ., 2008, Surficial-geologic map of the Salcha River-Pogo area, Big Delta Quadrangle, Alaska: Alaska , Engineering - geologic map, Alaska Highway corridor, Delta Junction to Dot Lake, Alaska: Alaska Division of geologic map of the Salcha River-Pogo area, Big Delta Quadrangle, Alaska: Alaska Division of Geological

  6. 33 CFR 100.T01-1057 - Special Local Regulations; Marine Events in Northern New England.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Events in Northern New England. 100.T01-1057 Section 100.T01-1057 Navigation and Navigable Waters COAST... § 100.T01-1057 Special Local Regulations; Marine Events in Northern New England. (a) Regulations. The general regulations contained in 33 CFR 100.120 as well as the following regulations apply to the events...

  7. 77 FR 43158 - Special Local Regulation; Battle on the Bay Powerboat Race Atlantic Ocean, Fire Island, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... 1625-AA08 Special Local Regulation; Battle on the Bay Powerboat Race Atlantic Ocean, Fire Island, NY... temporary special local regulation on the navigable waters of the Atlantic Ocean off Smith Point Park, Fire... on the Atlantic Ocean off Smith Point Park, Fire Island, NY and will feature six classes of offshore...

  8. 75 FR 30296 - Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ...-AA08 Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD... Chestertown, MD during the Maryland Swim for Life. Special local regulations are necessary to provide for the safety of life on navigable waters during the event. DATES: This rule is effective from 5:30 a.m. to 2:30...

  9. 77 FR 23123 - Special Local Regulation; Smokin The Lake; Gulfport Lake; Gulfport, MS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ...-AA08 Special Local Regulation; Smokin The Lake; Gulfport Lake; Gulfport, MS AGENCY: Coast Guard, DHS... regulation for a portion of Gulfport Lake in Gulfport, MS. This action is necessary for the safeguard of... The Lake high speed boat races on May 5 and 6, 2012. Entry into, transiting or anchoring in this area...

  10. Alaska's Economy: What's Ahead?

    ERIC Educational Resources Information Center

    Alaska Review of Social and Economic Conditions, 1987

    1987-01-01

    This review describes Alaska's economic boom of the early 1980s, the current recession, and economic projections for the 1990s. Alaska's economy is largely influenced by oil prices, since petroleum revenues make up 80% of the state government's unrestricted general fund revenues. Expansive state spending was responsible for most of Alaska's…

  11. Cooperative Alaska Forest Inventory

    Treesearch

    Thomas Malone; Jingjing Liang; Edmond C. Packee

    2009-01-01

    The Cooperative Alaska Forest Inventory (CAFI) is a comprehensive database of boreal forest conditions and dynamics in Alaska. The CAFI consists of field-gathered information from numerous permanent sample plots distributed across interior and south-central Alaska including the Kenai Peninsula. The CAFI currently has 570 permanent sample plots on 190 sites...

  12. 7 CFR 272.7 - Procedures for program administration in Alaska.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Procedures for program administration in Alaska. 272.7 Section 272.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM REQUIREMENTS FOR PARTICIPATING...

  13. Appellate Courts - Alaska Court System

    Science.gov Websites

    Court Cases Appellate Case Management System Oral Argument Supreme Court Calendar, Court of Appeals , which contains the Alaska cases excerpted from P.2d and P.3d. The Pacific Reporter or the Alaska the Alaska cases excerpted from P.2d and P.3d. The Pacific Reporter or the Alaska Reporter is

  14. Alaska looks HOT!

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Belcher, J.

    Production in Alaska has been sluggish in recent years, with activity in the Prudhoe Bay region in the North Slope on a steady decline. Alaska North Slope (ANS) production topped out in 1988 at 2.037 MMbo/d, with 1.6 MMbo/d from Prudhoe Bay. This year operators expect to produce 788 Mbo/d from Prudhoe Bay, falling to 739 Mbo/d next year. ANS production as a whole should reach 1.3 MMbo/d this year, sliding to 1.29 MMbo/d in 1998. These declining numbers had industry officials and politicians talking about the early death of the Trans-Alaskan Pipeline System-the vital link between ANS crude andmore » markets. But enhanced drilling technology coupled with a vastly improved relationship between the state government and industry have made development in Alaska more economical and attractive. Alaska`s Democratic Gov. Tommy Knowles is fond of telling industry {open_quotes}we`re open for business.{close_quotes} New discoveries on the North Slope and in the Cook Inlet are bringing a renewed sense of optimism to the Alaska exploration and production industry. Attempts by Congress to lift a moratorium on exploration and production activity in the Arctic National Wildlife Refuge (ANWR) have been thwarted thus far, but momentum appears to be with proponents of ANWR drilling.« less

  15. Alaska Tidal Datum Portal | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Engineering Geology Alaska Tidal Datum Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Portal Unambiguous vertical datums in the coastal environment are critical to the evaluation of natural human life, property, and the coastal environment. January 2017 - Update Summary Alaska Tidal Datum

  16. Voltage-Boosting Driver For Switching Regulator

    NASA Technical Reports Server (NTRS)

    Trump, Ronald C.

    1990-01-01

    Driver circuit assures availability of 10- to 15-V gate-to-source voltage needed to turn on n-channel metal oxide/semiconductor field-effect transistor (MOSFET) acting as switch in switching voltage regulator. Includes voltage-boosting circuit efficiently providing gate voltage 10 to 15 V above supply voltage. Contains no exotic parts and does not require additional power supply. Consists of NAND gate and dual voltage booster operating in conjunction with pulse-width modulator part of regulator.

  17. Modulation of BK channel voltage gating by different auxiliary β subunits

    PubMed Central

    Contreras, Gustavo F.; Neely, Alan; Alvarez, Osvaldo; Gonzalez, Carlos; Latorre, Ramon

    2012-01-01

    Calcium- and voltage-activated potassium channels (BK) are regulated by a multiplicity of signals. The prevailing view is that different BK gating mechanisms converge to determine channel opening and that these gating mechanisms are allosterically coupled. In most instances the pore forming α subunit of BK is associated with one of four alternative β subunits that appear to target specific gating mechanisms to regulate the channel activity. In particular, β1 stabilizes the active configuration of the BK voltage sensor having a large effect on BK Ca2+ sensitivity. To determine the extent to which β subunits regulate the BK voltage sensor, we measured gating currents induced by the pore-forming BK α subunit alone and with the different β subunits expressed in Xenopus oocytes (β1, β2IR, β3b, and β4). We found that β1, β2, and β4 stabilize the BK voltage sensor in the active conformation. β3 has no effect on voltage sensor equilibrium. In addition, β4 decreases the apparent number of charges per voltage sensor. The decrease in the charge associated with the voltage sensor in α β4 channels explains most of their biophysical properties. For channels composed of the α subunit alone, gating charge increases slowly with pulse duration as expected if a significant fraction of this charge develops with a time course comparable to that of K+ current activation. In the presence of β1, β2, and β4 this slow component develops in advance of and much more rapidly than ion current activation, suggesting that BK channel opening proceeds in two steps. PMID:23112204

  18. Alaska Job Center Network

    Science.gov Websites

    Job Centers Toll-free in Alaska (877)724-2539 *Workshop Schedules are linked under participating Job : midtown.jobcenter@alaska.gov Employers: anchorage.employers@alaska.gov Toll free Anchorage Employer Phone: 1-888-830 -1149 Phone: 842-5579 Fax: 842-5679, Toll Free: 1-800-478-5579 Job Seekers & Employers

  19. 78 FR 66844 - Special Local Regulation; Southern California Annual Marine Events for the San Diego Captain of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... enforce the special local regulations in 33 CFR 100.1101 during the San Diego Fall Classic, held on... INFORMATION: The Coast Guard will enforce the special local regulations in 33 CFR 100.1101 in support of the San Diego Fall Classic (Item 1 on Table 1 of 33 CFR 100.1101). The Coast Guard will enforce the...

  20. A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization.

    PubMed

    Zhou, Lei; Olivier, Nelson B; Yao, Huan; Young, Edgar C; Siegelbaum, Steven A

    2004-12-02

    Cyclic nucleotides directly enhance the opening of the tetrameric CNG and HCN channels, although the mechanism remains unclear. We examined why HCN and certain CNG subunits form functional homomeric channels, whereas other CNG subunits only function in heteromeric channels. The "defect" in the CNGA4 subunit that prevents its homomeric expression was localized to its C-linker, which connects the transmembrane domain to the binding domain and contains a tripeptide that decreases the efficacy of ligand gating. Remarkably, replacement of the homologous HCN tripeptide with the CNGA4 sequence transformed cAMP into an inverse agonist that inhibits HCN channel opening. Using analytical ultracentrifugation, we identified the structural basis for this gating switch: whereas cAMP normally enhances the assembly of HCN C-terminal domains into a tetrameric gating ring, inclusion of the CNGA4 tripeptide reversed this action so that cAMP now causes gating ring disassembly. Thus, ligand gating depends on the dynamic oligomerization of C-terminal binding domains.

  1. 75 FR 51936 - Special Local Regulation for Marine Events; Roanoke River, Plymouth, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... regulations during the ``East Coast Drag Boat Association Race'', a power boat race to be held on the waters... boat race. DATES: This rule is effective from 8 a.m. August 28, 2010 through 9 p.m. August 29, 2010.... The danger posed by drag boat racing makes special local regulations necessary to provide for the...

  2. Alaska Natives & the Land.

    ERIC Educational Resources Information Center

    Arnold, Robert D.; And Others

    Pursuant to the Native land claims within Alaska, this compilation of background data and interpretive materials relevant to a fair resolution of the Alaska Native problem seeks to record data and information on the Native peoples; the land and resources of Alaska and their uses by the people in the past and present; land ownership; and future…

  3. Alaska Women: A Databook.

    ERIC Educational Resources Information Center

    White, Karen; Baker, Barbara

    This data book uses survey and census information to record social and economic changes of the past three decades and their effects upon the role of Alaska women in society. Results show Alaska women comprise 47% of the state population, an increase of 9% since 1950. Marriage continues as the predominant living arrangement for Alaska women,…

  4. Alaska Board of Forestry

    Science.gov Websites

    Natural Resources / Division of Forestry Alaska Board of Forestry The nine-member Alaska Board of Forestry advises the state on forest practices issues and provides a forum for discussion and resolution of forest management issues on state land. The board also reviews all proposed changes to the Alaska Forest Resources

  5. Alaska Interagency Ecosystem Health Work Group

    USGS Publications Warehouse

    Shasby, Mark

    2009-01-01

    The Alaska Interagency Ecosystem Health Work Group is a community of practice that recognizes the interconnections between the health of ecosystems, wildlife, and humans and meets to facilitate the exchange of ideas, data, and research opportunities. Membership includes the Alaska Native Tribal Health Consortium, U.S. Geological Survey, Alaska Department of Environmental Conservation, Alaska Department of Health and Social Services, Centers for Disease Control and Prevention, U.S. Fish and Wildlife Service, Alaska Sea Life Center, U.S. Environmental Protection Agency, and Alaska Department of Fish and Game.

  6. UNIT, ALASKA.

    ERIC Educational Resources Information Center

    Louisiana Arts and Science Center, Baton Rouge.

    THE UNIT DESCRIBED IN THIS BOOKLET DEALS WITH THE GEOGRAPHY OF ALASKA. THE UNIT IS PRESENTED IN OUTLINE FORM. THE FIRST SECTION DEALS PRINCIPALLY WITH THE PHYSICAL GEOGRAPHY OF ALASKA. DISCUSSED ARE (1) THE SIZE, (2) THE MAJOR LAND REGIONS, (3) THE MOUNTAINS, VOLCANOES, GLACIERS, AND RIVERS, (4) THE NATURAL RESOURCES, AND (5) THE CLIMATE. THE…

  7. Alaska's renewable energy potential.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2009-02-01

    This paper delivers a brief survey of renewable energy technologies applicable to Alaska's climate, latitude, geography, and geology. We first identify Alaska's natural renewable energy resources and which renewable energy technologies would be most productive. e survey the current state of renewable energy technologies and research efforts within the U.S. and, where appropriate, internationally. We also present information on the current state of Alaska's renewable energy assets, incentives, and commercial enterprises. Finally, we escribe places where research efforts at Sandia National Laboratories could assist the state of Alaska with its renewable energy technology investment efforts.

  8. 77 FR 19534 - Special Local Regulations; Savannah Tall Ships Challenge, Savannah River, Savannah, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ...-AA08 Special Local Regulations; Savannah Tall Ships Challenge, Savannah River, Savannah, GA AGENCY... regulations on the Savannah River in Savannah, Georgia during the Savannah Tall Ships Challenge. The Savannah Tall Ships Challenge will take place from Thursday, May 3, 2012 through Monday, May 7, 2012...

  9. 75 FR 61511 - Intent To Prepare a Supplemental Environmental Impact Statement: Outer Continental Shelf, Alaska...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management, Regulation and Enforcement Intent To Prepare a Supplemental Environmental Impact Statement: Outer Continental Shelf, Alaska OCS Region, Chukchi Sea Planning Area, Oil and Gas Lease Sale 193 AGENCY: Bureau of Ocean Energy Management, Regulation...

  10. Oxidative Modulation of Voltage-Gated Potassium Channels

    PubMed Central

    Sahoo, Nirakar; Hoshi, Toshinori

    2014-01-01

    Abstract Significance: Voltage-gated K+ channels are a large family of K+-selective ion channel protein complexes that open on membrane depolarization. These K+ channels are expressed in diverse tissues and their function is vital for numerous physiological processes, in particular of neurons and muscle cells. Potentially reversible oxidative regulation of voltage-gated K+ channels by reactive species such as reactive oxygen species (ROS) represents a contributing mechanism of normal cellular plasticity and may play important roles in diverse pathologies including neurodegenerative diseases. Recent Advances: Studies using various protocols of oxidative modification, site-directed mutagenesis, and structural and kinetic modeling provide a broader phenomenology and emerging mechanistic insights. Critical Issues: Physicochemical mechanisms of the functional consequences of oxidative modifications of voltage-gated K+ channels are only beginning to be revealed. In vivo documentation of oxidative modifications of specific amino-acid residues of various voltage-gated K+ channel proteins, including the target specificity issue, is largely absent. Future Directions: High-resolution chemical and proteomic analysis of ion channel proteins with respect to oxidative modification combined with ongoing studies on channel structure and function will provide a better understanding of how the function of voltage-gated K+ channels is tuned by ROS and the corresponding reducing enzymes to meet cellular needs. Antioxid. Redox Signal. 21, 933–952. PMID:24040918

  11. A novel optical gating method for laser gated imaging

    NASA Astrophysics Data System (ADS)

    Ginat, Ran; Schneider, Ron; Zohar, Eyal; Nesher, Ofer

    2013-06-01

    For the past 15 years, Elbit Systems is developing time-resolved active laser-gated imaging (LGI) systems for various applications. Traditional LGI systems are based on high sensitive gated sensors, synchronized to pulsed laser sources. Elbit propriety multi-pulse per frame method, which is being implemented in LGI systems, improves significantly the imaging quality. A significant characteristic of the LGI is its ability to penetrate a disturbing media, such as rain, haze and some fog types. Current LGI systems are based on image intensifier (II) sensors, limiting the system in spectral response, image quality, reliability and cost. A novel propriety optical gating module was developed in Elbit, untying the dependency of LGI system on II. The optical gating module is not bounded to the radiance wavelength and positioned between the system optics and the sensor. This optical gating method supports the use of conventional solid state sensors. By selecting the appropriate solid state sensor, the new LGI systems can operate at any desired wavelength. In this paper we present the new gating method characteristics, performance and its advantages over the II gating method. The use of the gated imaging systems is described in a variety of applications, including results from latest field experiments.

  12. College Persistence of Alaska Native Students: An Assessment of the Rural Alaska Honors Institute, 1983-88.

    ERIC Educational Resources Information Center

    Gaylord, Thomas A.; Kaul, Gitanjali

    Despite efforts by educators, full participation by Alaska native students in the state's colleges and universities has not yet been achieved. Alaska Natives are the state's only racial group that is underrepresented in enrollments at the University of Alaska (UA). This report examines the contribution of the Rural Alaska Honors Institute (RAHI)…

  13. 77 FR 72956 - Special Local Regulation; Southern California Annual Marine Events for the San Diego Captain of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ....1101 will be enforced on December 9 and December 16, 2012 from 5:30 p.m. until 8:30 p.m. each day. FOR... special local regulations in 33 CFR 100.1101 in support of the San Diego Parade of Lights (Item 5 on Table 1 of 33 CFR 100.1101). The Coast Guard will enforce the special local regulations between the...

  14. Role of voltage-gated K(+) channels in regulating Ca(2+) entry in rat cortical astrocytes.

    PubMed

    Wu, King-Chuen; Kuo, Chang-Shin; Chao, Chia-Chia; Huang, Chieh-Chen; Tu, Yuan-Kun; Chan, Paul; Leung, Yuk-Man

    2015-03-01

    Astrocytes have multiple functions such as provision of nourishment and mechanical support to the nervous system, helping to clear extracellular metabolites of neurons and modulating synaptic transmission by releasing gliotransmitters. In excitable cells, voltage-gated K(+) (Kv) channels serve to repolarize during action potentials. Astrocytes are considered non-excitable cells since they are not able to generate action potentials. There is an abundant expression of various Kv channels in astrocytes but the functions of these Kv channels remain unclear. We examined whether these astrocyte Kv channels regulate astrocyte "excitability" in the form of cytosolic Ca(2+) signaling. Electrophysiological examination revealed that neonatal rat cortical astrocytes possessed both delayed rectifier type and A-type Kv channels. Pharmacological blockade of both delayed rectifier Kv channels by TEA and A-type Kv channels by quinidine significantly suppressed store-operated Ca(2+) influx; however, TEA alone or quinidine alone did not suffice to cause such suppression. TEA and quinidine together dramatically enhanced current injection-triggered membrane potential overshoot (depolarization); either drug alone caused much smaller enhancements. Taken together, the results suggest both delayed rectifier and A-type Kv channels regulate astrocyte Ca(2+) signaling via controlling membrane potential.

  15. Specialized testing of asphalt cements from various ADOT&PF paving projects.

    DOT National Transportation Integrated Search

    2015-06-01

    The Alaska Department of Transportation and Public Facilities (ADOT&PF) sampled five different asphalt cements for specialized testing at Queens University in : Kingston, Ontario. This report documents and discusses the findings. The tested asphal...

  16. Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.

    PubMed

    Lin, Wen-Ying; Sohma, Yoshiro; Hwang, Tzyh-Chang

    2016-09-01

    Cystic fibrosis (CF) is caused by loss-of-function mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene encoding a phosphorylation-activated but ATP-gated chloride channel. Previous studies suggested that VX-770 [ivacaftor, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide], a CFTR potentiator now used in clinics, increases the open probability of CFTR by shifting the gating conformational changes to favor the open channel configuration. Recently the chloride channel blocker and CFTR potentiator 5-nitro-2-(3-phenylpropylamino) benzoate (NPPB) has been reported to enhance CFTR activity by a mechanism that exploits the ATP hydrolysis-driven, nonequilibrium gating mechanism unique to CFTR. Surprisingly however, NPPB increased the activity of nonhydrolytic G551D-CFTR, the third most common disease-associated mutation. Here, we further investigated the mechanism of NPPB's effects on CFTR gating by assessing its interaction with well-studied VX-770. Interestingly, once G551D-CFTR was maximally potentiated by VX-770, NPPB further increased its activity. However, quantitative analysis of this drug-drug interaction suggests that this pharmacologic synergism is not due to independent actions of NPPB and VX-770 on CFTR gating; instead, our data support a dependent mechanism involving two distinct binding sites. This latter idea is further supported by the observation that the locked-open time of a hydrolysis-deficient mutant K1250A was shortened by NPPB but prolonged by VX-770. In addition, the effectiveness of NPPB, but not of VX-770, was greatly diminished in a mutant whose second nucleotide-binding domain was completely removed. Interpreting these results under the framework of current understanding of CFTR gating not only reveals insights into the mechanism of action for different CFTR potentiators but also brings us one step forward to a more complete schematic for CFTR gating. Copyright © 2016 by The American

  17. Self-Determination in Health Research: An Alaska Native Example of Tribal Ownership and Research Regulation

    PubMed Central

    Hiratsuka, Vanessa Y.; Beans, Julie A.; Robinson, Renee F.; Shaw, Jennifer L.; Sylvester, Ileen; Dillard, Denise A.

    2017-01-01

    Alaska Native (AN) and American Indian (AI) people are underrepresented in health research, yet many decline to participate in studies due to past researcher misconduct. Southcentral Foundation (SCF), an Alaska Native-owned and operated health care organization, is transforming the relationship between researchers and the tribal community by making trust and accountability required features of health research in AN/AI communities. In 1998, SCF assumed ownership from the federal government of health services for AN/AI people in south central Alaska and transformed the health system into a relationship-based model of care. This change reimagines how researchers interact with tribal communities and established community oversight of all health research conducted with AN/AI people in the region. We describe the SCF research review process, which requires tribal approval of the research concept, full proposal, and dissemination products, as well as local institutional review board approval, and a researcher-signed contract. This review evaluates research through the lens of tribal principles, practices, and priorities. The SCF example provides a framework for other tribes and organizations seeking to reshape the future of health research in AN/AI communities. PMID:29088111

  18. Laws Affecting Children with Special Needs: Selected Federal Statutes and Regulations.

    ERIC Educational Resources Information Center

    Walsh, Sharon, Comp.; McKenna, Patricia, Comp.

    The book presents the complete texts of federal statutes and parallel regulations for the following laws affecting children with special needs: Education of the Handicapped Act, Part A-Part H; three programs under the Elementary and Secondary Education Act--Chapter 1, Disadvantaged; Chapter 1, Even Start; and Chapter 1, Handicapped; the…

  19. 75 FR 16700 - Special Local Regulation, Swim Across the Sound, Long Island Sound, Port Jefferson, NY to Captain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ...-AA08 Special Local Regulation, Swim Across the Sound, Long Island Sound, Port Jefferson, NY to Captain... permanent Special Local Regulation on the navigable waters of Long Island Sound between Port Jefferson, NY and Captain's Cove Seaport, Bridgeport, CT due to the annual Swim Across the Sound event. The proposed...

  20. Functional profile of black spruce wetlands in Alaska

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Post, R.A.

    1996-09-01

    The profile describes the ecologic context and wetland functions of black spruce (Picea mariana) wetlands (BSWs) covering about 14 million ha of Alaska taiga. Ecologic descriptions include climate, permafrost, landforms, post-Pleistocene vegetation, fire, successional processes, black spruce community types and adaptations, and characteristics of BSWs. The profile describes human activities potentially affecting BSWs and identifies research literature and data gaps generally applicable to BSWs. Hydrologic, water quality, global biogeochemical, and ecologic functions of BSWs, as well as their socioeconomic uses, appear in the profile, along with potential functional indicators, expected sensitivities of functions to fill placement or weltand drainage, andmore » potential mitigation strategies for impacts. Functional analysis separately considers ombrotrophic and minerotrophic BSWs where appropriate. Depending on trophic status, Alaska`s BSWs perform several low-magnitude hydrologic (groundwater discharge and recharge, flow regulation, and erosion control) and ecologic (nutrient export, nutrient cycling, and food-chain support) functions and several substantial water quality (sediment retention, nutrient transformation, nutrient uptake, and contaminant removal), global biogeochemical (carbon cycling and storage), and ecologic (avian and mammalian habitat) functions. BSWs also provide important socioeconomic uses: harvested of wetland-dependent fish, wildlife, and plant resources and active winter recreation.« less

  1. Trophic ecology of introduced populations of Alaska blackfish (Dallia pectoralis) in the Cook Inlet Basin, Alaska.

    PubMed

    Eidam, Dona M; von Hippel, Frank A; Carlson, Matthew L; Lassuy, Dennis R; López, J Andrés

    2016-07-01

    Introduced non-native fishes have the potential to substantially alter aquatic ecology in the introduced range through competition and predation. The Alaska blackfish ( Dallia pectoralis ) is a freshwater fish endemic to Chukotka and Alaska north of the Alaska Range (Beringia); the species was introduced outside of its native range to the Cook Inlet Basin of Alaska in the 1950s, where it has since become widespread. Here we characterize the diet of Alaska blackfish at three Cook Inlet Basin sites, including a lake, a stream, and a wetland. We analyze stomach plus esophageal contents to assess potential impacts on native species via competition or predation. Alaska blackfish in the Cook Inlet Basin consume a wide range of prey, with major prey consisting of epiphytic/benthic dipteran larvae, gastropods, and ostracods. Diets of the introduced populations of Alaska blackfish are similar in composition to those of native juvenile salmonids and stickleback. Thus, Alaska blackfish may affect native fish populations via competition. Fish ranked third in prey importance for both lake and stream blackfish diets but were of minor importance for wetland blackfish.

  2. Trophic ecology of introduced populations of Alaska blackfish (Dallia pectoralis) in the Cook Inlet Basin, Alaska

    PubMed Central

    Eidam, Dona M.; Carlson, Matthew L.; Lassuy, Dennis R.; López, J. Andrés

    2016-01-01

    Introduced non-native fishes have the potential to substantially alter aquatic ecology in the introduced range through competition and predation. The Alaska blackfish (Dallia pectoralis) is a freshwater fish endemic to Chukotka and Alaska north of the Alaska Range (Beringia); the species was introduced outside of its native range to the Cook Inlet Basin of Alaska in the 1950s, where it has since become widespread. Here we characterize the diet of Alaska blackfish at three Cook Inlet Basin sites, including a lake, a stream, and a wetland. We analyze stomach plus esophageal contents to assess potential impacts on native species via competition or predation. Alaska blackfish in the Cook Inlet Basin consume a wide range of prey, with major prey consisting of epiphytic/benthic dipteran larvae, gastropods, and ostracods. Diets of the introduced populations of Alaska blackfish are similar in composition to those of native juvenile salmonids and stickleback. Thus, Alaska blackfish may affect native fish populations via competition. Fish ranked third in prey importance for both lake and stream blackfish diets but were of minor importance for wetland blackfish. PMID:28082763

  3. Electrifying Alaska

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reinemer, V.

    Alaska's diverse systems for electric power include only 4% by private utilities. Large distances and small markets make transmission impractical for the most part. Rates are variable, although the state average is low. Energy sources, except nuclear, are abundant: half the US coal reserves are in Alaska. In addition, it has geothermal, tidal, biomass, solar, wind, and hydroelectric power. Energy construction and study programs are centered in the Alaska Power Authority and include using waste heat from village diesel generators. Hydro potential is good, but access, distances, and environmental effects must be considered. The Terror Lake, Tyee Lake, Swan Lake,more » and Susitna projects are described and transmission construction, including the 345-kW Railbelt intertie, is discussed. 1 figure.« less

  4. Altering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl− channel

    PubMed Central

    Xu, Weiyi; Sheppard, David N.

    2017-01-01

    Key points The cystic fibrosis transmembrane conductance regulator (CFTR), which is defective in the genetic disease cystic fibrosis (CF), forms a gated pathway for chloride movement regulated by intracellular ATP.To understand better CFTR function, we investigated the regulation of channel openings by intracellular pH.We found that short‐lived channel closures during channel openings represent subtle changes in the structure of CFTR that are regulated by intracellular pH, in part, at ATP‐binding site 1 formed by the nucleotide‐binding domains.Our results provide a framework for future studies to understand better the regulation of channel openings, the dysfunction of CFTR in CF and the action of drugs that repair CFTR gating defects. Abstract Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP‐gated Cl− channel defective in the genetic disease cystic fibrosis (CF). The gating behaviour of CFTR is characterized by bursts of channel openings interrupted by brief, flickery closures, separated by long closures between bursts. Entry to and exit from an open burst is controlled by the interaction of ATP with two ATP‐binding sites, sites 1 and 2, in CFTR. To understand better the kinetic basis of CFTR intraburst gating, we investigated the single‐channel activity of human CFTR at different intracellular pH (pHi) values. When compared with the control (pHi 7.3), acidifying pHi to 6.3 or alkalinizing pHi to 8.3 and 8.8 caused small reductions in the open‐time constant (τo) of wild‐type CFTR. By contrast, the fast closed‐time constant (τcf), which describes the short‐lived closures that interrupt open bursts, was greatly increased at pHi 5.8 and 6.3. To analyse intraburst kinetics, we used linear three‐state gating schemes. All data were satisfactorily modelled by the C1 ↔ O ↔ C2 kinetic scheme. Changing the intracellular ATP concentration was without effect on τo, τcf and their responses to pHi changes. However, mutations

  5. Forkhead Transcription Factor Fd3F Cooperates with Rfx to Regulate a Gene Expression Program for Mechanosensory Cilia Specialization

    PubMed Central

    Newton, Fay G.; zur Lage, Petra I.; Karak, Somdatta; Moore, Daniel J.; Göpfert, Martin C.; Jarman, Andrew P.

    2012-01-01

    Summary Cilia have evolved hugely diverse structures and functions to participate in a wide variety of developmental and physiological processes. Ciliary specialization requires differences in gene expression, but few transcription factors are known to regulate this, and their molecular function is unclear. Here, we show that the Drosophila Forkhead box (Fox) gene, fd3F, is required for specialization of the mechanosensory cilium of chordotonal (Ch) neurons. fd3F regulates genes for Ch-specific axonemal dyneins and TRPV ion channels, which are required for sensory transduction, and retrograde transport genes, which are required to differentiate their distinct motile and sensory ciliary zones. fd3F is reminiscent of vertebrate Foxj1, a motile cilia regulator, but fd3F regulates motility genes as part of a broader sensory regulation program. Fd3F cooperates with the pan-ciliary transcription factor, Rfx, to regulate its targets directly. This illuminates pathways involved in ciliary specialization and the molecular mechanism of transcription factors that regulate them. PMID:22698283

  6. 78 FR 33700 - Special Local Regulations for Marine Events, Pleasantville Aquatics 15th Annual 5K Open Water...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ...-AA08 Special Local Regulations for Marine Events, Pleasantville Aquatics 15th Annual 5K Open Water Swim... from operating while a swim event is taking place. This special local regulation is necessary to... Docket Management Facility in Room W12-140 on the ground floor of the Department of Transportation West...

  7. 75 FR 35516 - Pipeline Safety: Request for Special Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-22

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0147] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials... with the Class 1 location portion of a 7.4 mile natural gas pipeline to be constructed in Alaska. This...

  8. Publications - GMC 193 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical materials: Alaska State F #1, washed cuttings (13,980' - 13,990'); West Mikkelsen State #1, Canning River

  9. Alaska's State Forests

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  10. 78 FR 38829 - Special Local Regulations; Recurring Marine Events in the Seventh Coast Guard District

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... regulation for the St. John 4th of July Carnival Fireworks Display from 8 p.m. until 10 p.m. on July 4, 2013...: The Coast Guard will enforce the special local regulation for the annual St. John 4th of July Carnival...

  11. Current Issues in Alaska Wetland Management

    DTIC Science & Technology

    1994-08-01

    studies at a range of northern wetlands over about 20% of the state have been sites in North America , Europe and Russia mapped at a scale of 1:63,360...arctic or subspecies of waterfowl than any comparable wetlands do not regulate spring runoff or store area in North America , while the Yukon Flats in...Alaska. U.S. tion in arctic and subarctic North America . A Fish and Wildlife Service, FWS/OB5-82/22. literature review, USA Cold Regions Research and

  12. 49 CFR 71.11 - Alaska zone.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Alaska zone. 71.11 Section 71.11 Transportation Office of the Secretary of Transportation STANDARD TIME ZONE BOUNDARIES § 71.11 Alaska zone. The sixth zone, the Alaska standard time zone, includes the entire State of Alaska, except as provided in § 71.12...

  13. 78 FR 40391 - Special Local Regulations; Dinghy Poker Run, Middle River; Baltimore County, Essex, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... the rule is to ensure safety of life on navigable waters of the United States during the Dinghy Poker...: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard proposes to establish special... River. These special local regulations are necessary to provide for the safety of life on navigable...

  14. Applications of ERTS-1 imagery to terrestrial and marine environmental analyses in Alaska

    NASA Technical Reports Server (NTRS)

    Anderson, D. M.; Mckim, H. L.; Crowder, W. K.; Haugen, R. K.; Gatto, L. W.; Marlar, T. L.

    1974-01-01

    ERTS-1 imagery provides a means of distinguishing and monitoring estuarine surface water circulation patterns and changes in the relative sediment load of discharging rivers on a regional basis. It also will aid local fishing industries by augmenting currently available hydrologic and navigation charts. The interpretation of geologic and vegetation features resulted in preparation of improved surficial geology, vegetation and permafrost terrain maps at a scale of 1:1 million utilizing ERTS-1 band 7 imagery. This information will be further utilized in a route and site selection study for the Nome to Kobuk Road in central Alaska. Large river icings along the proposed Alaska pipeline route have been monitored. Sea ice deformation and drift northeast of Point Barrow, Alaska has been measured and shorefast ice accumulation and ablation along the west coast of Alaska is being mapped for the spring and early summer seasons. These data will be used for route and site selection, regional environmental analysis, identification and inventory of natural resources, land use planning, and in land use regulation and management.

  15. Gating of the designed trimeric/tetrameric voltage-gated H+ channel

    PubMed Central

    Fujiwara, Yuichiro; Kurokawa, Tatsuki; Takeshita, Kohei; Nakagawa, Atsushi; Larsson, H Peter; Okamura, Yasushi

    2013-01-01

    The voltage-gated H+ channel functions as a dimer, a configuration that is different from standard tetrameric voltage-gated channels. Each channel protomer has its own permeation pathway. The C-terminal coiled-coil domain has been shown to be necessary for both dimerization and cooperative gating in the two channel protomers. Here we report the gating cooperativity in trimeric and tetrameric Hv channels engineered by altering the hydrophobic core sequence of the coiled-coil assembly domain. Trimeric and tetrameric channels exhibited more rapid and less sigmoidal kinetics of activation of H+ permeation than dimeric channels, suggesting that some channel protomers in trimers and tetramers failed to produce gating cooperativity observed in wild-type dimers. Multimerization of trimer and tetramer channels were confirmed by the biochemical analysis of proteins, including crystallography. These findings indicate that the voltage-gated H+ channel is optimally designed as a dimeric channel on a solid foundation of the sequence pattern of the coiled-coil core, with efficient cooperative gating that ensures sustained and steep voltage-dependent H+ conductance in blood cells. PMID:23165764

  16. 78 FR 39314 - Notice of Availability of the Decision Record for the Delta River Special Recreation Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ...The Bureau of Land Management (BLM) announces the availability of the Decision Record (DR) for the Delta River Special Recreation Management Area and East Alaska Resource Management Plan Amendment (Approved Plan). The BLM-Alaska State Director, Bud C. Cribley, signed the DR on March 29, 2013. The DR constitutes the final decision of the Department on the plan and is effective immediately.

  17. MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

    PubMed Central

    Sakai, Atsushi; Saitow, Fumihito; Maruyama, Motoyo; Miyake, Noriko; Miyake, Koichi; Shimada, Takashi; Okada, Takashi; Suzuki, Hidenori

    2017-01-01

    miR-17-92 is a microRNA cluster with six distinct members. Here, we show that the miR-17-92 cluster and its individual members modulate chronic neuropathic pain. All cluster members are persistently upregulated in primary sensory neurons after nerve injury. Overexpression of miR-18a, miR-19a, miR-19b and miR-92a cluster members elicits mechanical allodynia in rats, while their blockade alleviates mechanical allodynia in a rat model of neuropathic pain. Plausible targets for the miR-17-92 cluster include genes encoding numerous voltage-gated potassium channels and their modulatory subunits. Single-cell analysis reveals extensive co-expression of miR-17-92 cluster and its predicted targets in primary sensory neurons. miR-17-92 downregulates the expression of potassium channels, and reduced outward potassium currents, in particular A-type currents. Combined application of potassium channel modulators synergistically alleviates mechanical allodynia induced by nerve injury or miR-17-92 overexpression. miR-17-92 cluster appears to cooperatively regulate the function of multiple voltage-gated potassium channel subunits, perpetuating mechanical allodynia. PMID:28677679

  18. 78 FR 22808 - Special Local Regulations; Pro Hydro-X Tour, Lake Dora; Tavares, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ...-AA08 Special Local Regulations; Pro Hydro-X Tour, Lake Dora; Tavares, FL AGENCY: Coast Guard, DHS... regulation on the waters on Lake Dora in Tavares, Florida during the Pro Hydro-X Tour, a series of high-speed... Hydro-X Tour, a series of high-speed personal watercraft races. The Pro Hydro-X Tour will be held on...

  19. A Rhizobium radiobacter Histidine Kinase Can Employ Both Boolean AND and OR Logic Gates to Initiate Pathogenesis.

    PubMed

    Fang, Fang; Lin, Yi-Han; Pierce, B Daniel; Lynn, David G

    2015-10-12

    The molecular logic gates that regulate gene circuits are necessarily intricate and highly regulated, particularly in the critical commitments necessary for pathogenesis. We now report simple AND and OR logic gates to be accessible within a single protein receptor. Pathogenesis by the bacterium Rhizobium radiobacter is mediated by a single histidine kinase, VirA, which processes multiple small molecule host signals (phenol and sugar). Mutagenesis analyses converged on a single signal integration node, and finer functional analyses revealed that a single residue could switch VirA from a functional AND logic gate to an OR gate where each of two signals activate independently. Host range preferences among natural strains of R. radiobacter correlate with these gate logic strategies. Although the precise mechanism for the signal integration node requires further analyses, long-range signal transmission through this histidine kinase can now be exploited for synthetic signaling circuits. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Publications - RDF 2015-5 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements WebGeochem Engineering Geology Alaska

  1. Publications - RI 2009-2 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements WebGeochem Engineering Geology Alaska

  2. Publications - RDF 2016-3 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements WebGeochem Engineering Geology Alaska

  3. Publications - RDF 2016-5 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements WebGeochem Engineering Geology Alaska

  4. Publications - RDF 2014-22 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements WebGeochem Engineering Geology Alaska

  5. Publications - RDF 2015-8 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    from the Tonsina area, Valdez Quadrangle, Alaska: Alaska Division of Geological & Geophysical Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  6. Protein Interaction Analysis Provides a Map of the Spatial and Temporal Organization of the Ciliary Gating Zone.

    PubMed

    Takao, Daisuke; Wang, Liang; Boss, Allison; Verhey, Kristen J

    2017-08-07

    The motility and signaling functions of the primary cilium require a unique protein and lipid composition that is determined by gating mechanisms localized at the base of the cilium. Several protein complexes localize to the gating zone and may regulate ciliary protein composition; however, the mechanisms of ciliary gating and the dynamics of the gating components are largely unknown. Here, we used the BiFC (bimolecular fluorescence complementation) assay and report for the first time on the protein-protein interactions that occur between ciliary gating components and transiting cargoes during ciliary entry. We find that the nucleoporin Nup62 and the C termini of the nephronophthisis (NPHP) proteins NPHP4 and NPHP5 interact with the axoneme-associated kinesin-2 motor KIF17 and thus spatially map to the inner region of the ciliary gating zone. Nup62 and NPHP4 exhibit rapid turnover at the transition zone and thus define dynamic components of the gate. We find that B9D1, AHI1, and the N termini of NPHP4 and NPHP5 interact with the transmembrane protein SSTR3 and thus spatially map to the outer region of the ciliary gating zone. B9D1, AHI1, and NPHP5 exhibit little to no turnover at the transition zone and thus define components of a stable gating structure. These data provide the first comprehensive map of the molecular orientations of gating zone components along the inner-to-outer axis of the ciliary gating zone. These results advance our understanding of the functional roles of gating zone components in regulating ciliary protein composition. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. 78 FR 20277 - Safety Zones & Special Local Regulations; Recurring Marine Events in Captain of the Port Long...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ...The Coast Guard proposes to add, delete, and modify safety zones and special local regulations and add language to clarify time frames and notification requirements for annual marine events in the Sector Long Island Sound Captain of the Port (COTP) Zone. When these regulated areas are activated and subject to enforcement, this rule would restrict vessels from portions of water areas during these recurring events. The safety zones and special local regulations will facilitate public notification of events and provide protective measures for the maritime public and event participants from the hazards associated with these recurring events.

  8. Publications - RDF 2015-16 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    rocks collected in 2015 in the Wrangellia mineral assessment area, Alaska: Alaska Division of Geological Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  9. Publications - RDF 2015-9 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    samples from the Zane Hills, Hughes and Shungnak quadrangles, Alaska: Alaska Division of Geological & Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  10. 78 FR 28167 - Special Local Regulation, Cruce a Nado Internacional de la Bahia de Ponce Puerto Rico, Bahia de...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... 1625-AA08 Special Local Regulation, Cruce a Nado Internacional de la Bahia de Ponce Puerto Rico, Bahia de Ponce; Ponce, PR AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast Guard proposes to establish a special local regulation on the waters of Bahia de Ponce in Ponce...

  11. Alaska geology revealed

    USGS Publications Warehouse

    Wilson, Frederic H.; Labay, Keith A.

    2016-11-09

    This map shows the generalized geology of Alaska, which helps us to understand where potential mineral deposits and energy resources might be found, define ecosystems, and ultimately, teach us about the earth history of the State. Rock units are grouped in very broad categories on the basis of age and general rock type. A much more detailed and fully referenced presentation of the geology of Alaska is available in the Geologic Map of Alaska (http://dx.doi.org/10.3133/sim3340). This product represents the simplification of thousands of individual rock units into just 39 broad groups. Even with this generalization, the sheer complexity of Alaskan geology remains evident.

  12. Voltage-gated Proton Channels

    PubMed Central

    DeCoursey, Thomas E.

    2014-01-01

    Voltage-gated proton channels, HV1, have vaulted from the realm of the esoteric into the forefront of a central question facing ion channel biophysicists, namely the mechanism by which voltage-dependent gating occurs. This transformation is the result of several factors. Identification of the gene in 2006 revealed that proton channels are homologues of the voltage-sensing domain of most other voltage-gated ion channels. Unique, or at least eccentric, properties of proton channels include dimeric architecture with dual conduction pathways, perfect proton selectivity, a single-channel conductance ~103 smaller than most ion channels, voltage-dependent gating that is strongly modulated by the pH gradient, ΔpH, and potent inhibition by Zn2+ (in many species) but an absence of other potent inhibitors. The recent identification of HV1 in three unicellular marine plankton species has dramatically expanded the phylogenetic family tree. Interest in proton channels in their own right has increased as important physiological roles have been identified in many cells. Proton channels trigger the bioluminescent flash of dinoflagellates, facilitate calcification by coccolithophores, regulate pH-dependent processes in eggs and sperm during fertilization, secrete acid to control the pH of airway fluids, facilitate histamine secretion by basophils, and play a signaling role in facilitating B-cell receptor mediated responses in B lymphocytes. The most elaborate and best-established functions occur in phagocytes, where proton channels optimize the activity of NADPH oxidase, an important producer of reactive oxygen species. Proton efflux mediated by HV1 balances the charge translocated across the membrane by electrons through NADPH oxidase, minimizes changes in cytoplasmic and phagosomal pH, limits osmotic swelling of the phagosome, and provides substrate H+ for the production of H2O2 and HOCl, reactive oxygen species crucial to killing pathogens. PMID:23798303

  13. Publications - PDF 96-17 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska the Fairbanks Mining District, Alaska, scale 1:63,360 (15.0 M) Digital Geospatial Data Digital © 2010 Webmaster State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State

  14. Publications - MP 156 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska /29446 Publication Products Report Report Information mp156.pdf (126.0 K) Digital Geospatial Data Digital State of Alaska © 2010 Webmaster State of Alaska myAlaska My Government Resident Business in Alaska

  15. Alaska Administrative Manual

    Science.gov Websites

    Search the Division of Finance site DOF State of Alaska Finance Home Content Area Accounting Charge Cards Administrative Manual Table of Contents Contains State of Alaska accounting/payroll policies and information clarifying accounting and payroll procedures. Policies are carried out through standard statewide procedures

  16. Publications - GMC 410 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    ) Keywords Geochemistry; Rare Earth Elements Top of Page Department of Natural Resources, Division of Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  17. Publications - GMC 409 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    ) Keywords Geochemistry; Rare Earth Elements Top of Page Department of Natural Resources, Division of Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  18. Publications - GMC 183 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical materials: AK State C #1, Bush Federal #1, Echooka Unit #1, Fin Creek Unit #1, E. De K. Leffingwell #1, Nora

  19. Alaska Native Education: Issues in the Nineties. Alaska Native Policy Papers.

    ERIC Educational Resources Information Center

    Kleinfeld, Judith

    This booklet identifies several crucial problems in Alaska Native education, for example: (1) Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Effects (FAE) occur in Alaska Native populations at relatively high rates and can produce mental retardation, hyperactivity, attention deficits, and learning disabilities; (2) while many Native rural school…

  20. Teleportation-based realization of an optical quantum two-qubit entangling gate

    PubMed Central

    Gao, Wei-Bo; Goebel, Alexander M.; Lu, Chao-Yang; Dai, Han-Ning; Wagenknecht, Claudia; Zhang, Qiang; Zhao, Bo; Peng, Cheng-Zhi; Chen, Zeng-Bing; Chen, Yu-Ao; Pan, Jian-Wei

    2010-01-01

    In recent years, there has been heightened interest in quantum teleportation, which allows for the transfer of unknown quantum states over arbitrary distances. Quantum teleportation not only serves as an essential ingredient in long-distance quantum communication, but also provides enabling technologies for practical quantum computation. Of particular interest is the scheme proposed by D. Gottesman and I. L. Chuang [(1999) Nature 402:390–393], showing that quantum gates can be implemented by teleporting qubits with the help of some special entangled states. Therefore, the construction of a quantum computer can be simply based on some multiparticle entangled states, Bell-state measurements, and single-qubit operations. The feasibility of this scheme relaxes experimental constraints on realizing universal quantum computation. Using two different methods, we demonstrate the smallest nontrivial module in such a scheme—a teleportation-based quantum entangling gate for two different photonic qubits. One uses a high-fidelity six-photon interferometer to realize controlled-NOT gates, and the other uses four-photon hyperentanglement to realize controlled-Phase gates. The results clearly demonstrate the working principles and the entangling capability of the gates. Our experiment represents an important step toward the realization of practical quantum computers and could lead to many further applications in linear optics quantum information processing. PMID:21098305

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