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Sample records for albion avenue burley

  1. 7. VIEW SHOWING SOUTH SIDE OF BURLEY SUBSTATION WITH DRYCLEANERS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW SHOWING SOUTH SIDE OF BURLEY SUBSTATION WITH DRYCLEANERS IN FOREGROUND AND SIDE OF SUBSTATION WITH BREAK BETWEEN 1913-1914 AND 1921 CONSTRUCTION PHASES IN BACKGROUND - Bonneville Power Administration Burley Substation, 1221 Albion Avenue, Burley, Cassia County, ID

  2. 3. VIEW SHOWING FRONT HALF OF NORTH SIDE OF BURLEY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW SHOWING FRONT HALF OF NORTH SIDE OF BURLEY SUBSTATION, LOOKING SOUTHWEST. BREAK BETWEEN 1913-1914 AND 1921 CONSTRUCTION PHASES, LOCATED BELOW AND ABOVE RIGHT EDGE OF SECOND WINDOW, FRONT LEFT OF PHOTOGRAPH - Bonneville Power Administration Burley Substation, 1221 Albion Avenue, Burley, Cassia County, ID

  3. 11. INTERIOR VIEW OF BURLEY SUBSTATION, SECOND STORY, LOOKING EAST, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. INTERIOR VIEW OF BURLEY SUBSTATION, SECOND STORY, LOOKING EAST, SHOWING PARTITIONS, POURED-IN-PLACE CONCRETE ROOF AND WATER- DAMAGED SOUTH WALL (BREAK BETWEEN 1913-1914 AND 1921 CONSTRUCTION PHASES IN FOREGROUND) - Bonneville Power Administration Burley Substation, 1221 Albion Avenue, Burley, Cassia County, ID

  4. Chicxulub Impact Ejecta From Albion Island, Belize

    NASA Technical Reports Server (NTRS)

    Ocampo, A.; Pope, K.; Fischer, A.; Alvarez, W.; Fouke, B.; Webster, C.; Vega, F.; Smit, J.; Fritsche, A.; Claeys, P.

    1999-01-01

    Impact ejecta from the Albion Formation are exposed in northern Belize. The ejecta come from the outer portion of the continuous ejecta blanket of the Chicxulub crater, which is located 360 km to the northwest.

  5. 33 CFR 80.1146 - Albion River, CA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Albion River, CA. 80.1146 Section 80.1146 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1146 Albion River, CA. A line drawn on an axis of 030° true through Albion River Light...

  6. Albion College Celebrates 130 Years with an Alvan Clark Telescope

    NASA Astrophysics Data System (ADS)

    Smeltekop, N. G.; Zellner, N. E. B.

    2014-07-01

    In 2013-2014, Albion College, an undergraduate liberal arts college in Albion, Michigan, will celebrate the 130th anniversary of its 8'' Alvan Clark refracting telescope and observatory building. Dedicated in 1883 and completed in 1884, the observatory is one of two surviving examples of a nineteenth-century astronomical building in Michigan. Its instruments also include a Fauth and Company sidereal clock and transit telescope. Several times each year the telescope is open to the public and to the campus community for public observing events. Here we describe the history of our Alvan Clark telescope and the events that will take place in 2013-2014.

  7. Leadership, Engagement, and the Small Liberal Arts College: Albion College and the Smart Community.

    ERIC Educational Resources Information Center

    Mitchell, Peter T.; Levine, Myron A.

    2001-01-01

    Describes the development of a new transformational vision for Albion College in Michigan, which led to a community envisioning process off campus. The result was a new city-college partnership designed to promote the development of the city of Albion as "The Smart Community." (EV)

  8. Results from the UK 3rd generation programme: Albion

    NASA Astrophysics Data System (ADS)

    McEwen, R. K.; Axcell, C.; Knowles, P.; Hoade, K. P.; Wilson, M.; Dennis, P. N. J.; Backhouse, P.; Gordon, N. T.

    2008-10-01

    Following the development of 1st Generation systems in the 1970s, thermal imaging has been in service with the UK armed forces for over 25 years and has proven itself to be a battle winning technology. More recently the wider accessibility to similar technologies within opposing forces has reduced the military advantage provided by these 1st Generation systems and a clear requirement has been identified by the UK MOD for thermal imaging sensors providing increased detection, recognition and identification (DRI) ranges together with a simplified logistical deployment burden and reduced through-life costs. In late 2005, the UK MOD initiated a programme known as "Albion" to develop high performance 3rd Generation single waveband infrared detectors to meet this requirement. At the same time, under a separate programme supporting higher risk technology, a dual waveband infrared detector was also developed. The development phase of the Albion programme has now been completed and prototype detectors are now available and have been integrated into demonstration thermal imaging cameras. The Albion programme has now progressed into the second phase, incorporating both single and dual waveband devices, focussing on low rate initial production (LRIP) and qualification of the devices for military applications. All of the detectors have been fabricated using cadmium mercury telluride material (CMT), grown by metal organic vapour phase epitaxy (MOVPE) on low cost, gallium arsenide (GaAs) substrates and bump bonded to the silicon read out circuit (ROIC). This paper discusses the design features of the 3rd Generation detectors developed in the UK together with the results obtained from the prototype devices both in the laboratory and when integrated into field deployable thermal imaging cameras.

  9. 3. Photocopy of photograph ('Town and Community Planning, Walter Burley ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of photograph ('Town and Community Planning, Walter Burley Griffin,' Western Architect, Vol. 19, No. 8, August, 1913, following page 80) ca 1913 MAIN FACADE AND GARAGE FACADE - Arthur L. Rule House, 11 South Rock Glen, Mason City, Cerro Gordo County, IA

  10. Albion College Votes "No Agent:" A Case Study. Special Report No. 7.

    ERIC Educational Resources Information Center

    Lussier, Virginia Lee

    This case study details the events preceeding a collective bargaining vote at Albion College and indicates the outcome and implications for the faculty. Emphasis is placed on background information, preelection events, collective bargaining agents, administrative response, and the elections. Conclusions discuss the advantages and disadvantages of…

  11. 76 FR 37807 - Albion Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Albion Hydro, LLC; Notice of Preliminary Permit Application Accepted for... 55 acre reservoir having a normal storage capacity of about 235 acre-feet (ac-ft) at elevation of...

  12. Celebrating 130 Years of the Alvan Clark Telescope at Albion College

    NASA Astrophysics Data System (ADS)

    Zellner, Nicolle; Smeltekop, N. Garrett

    2014-01-01

    This year, 2013-2014, marks the 130th anniversary of the 8” Alvan Clark refracting telescope and observatory building at Albion College, an undergraduate college in Albion, MI. Completed in 1884, the observatory is an excellent example of a nineteenth century astronomical building; its telescope is still useable and other instruments (Fauth and Company sidereal clock, transit telescope, and chronograph) are in very good condition. The building has a long history, serving once as a barracks for World War I soldiers, and the telescope has helped to train the next generation of scientists, from Forest Ray Moulton (Class of 1894) to present-day students. Several times each year, the telescope is open to the public and to the campus community for public observing events, and during the anniversary year, several other activities are planned. I will describe the history of our observatory and its people and give an overview of the events planned for this year.

  13. Elevation of Warrington Avenue Bridge, southbound of Warrington Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation of Warrington Avenue Bridge, southbound of Warrington Avenue - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  14. 7 CFR 29.75a - Display of burley tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Display of burley tobacco on auction warehouse floors... COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS TOBACCO INSPECTION Regulations Mandatory Inspection § 29.75a Display of burley tobacco on auction warehouse floors in designated markets. (a)(1) Each...

  15. 7 CFR 29.75a - Display of burley tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Display of burley tobacco on auction warehouse floors... COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS TOBACCO INSPECTION Regulations Mandatory Inspection § 29.75a Display of burley tobacco on auction warehouse floors in designated markets. (a)(1) Each...

  16. 7 CFR 29.75a - Display of burley tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Display of burley tobacco on auction warehouse floors... COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS TOBACCO INSPECTION Regulations Mandatory Inspection § 29.75a Display of burley tobacco on auction warehouse floors in designated markets. (a)(1) Each...

  17. Geochemistry of formation waters from the Lower Silurian Clinton Formation (Albion Sandstone), eastern Ohio

    SciTech Connect

    Sanders, L.L. )

    1991-10-01

    Waters of the petroleum-bearing Clinton formation (Albion Sandstone) of eastern Ohio are highly concentrated brines with average total dissolved solids (TDS) of 250,000 ppm. Sodium, calcium, and chloride account for 97% of the TDS. Distribution of divalent metal chlorides (MCl{sub 2}) allows inference of an up-dip paleoflow direction, although present-day flow is probably down-dip paleoflow direction, although present-day flow is probably down-dip. Solute distribution may have been emplaced during early basin development; it thus provides a snapshot of paleoflow. Formation structure alone can not explain MCl{sub 2} trends; they probably also are controlled by regional variation in salt thickness. Major constituent data do not indicate that membrane filtration affected the waters. High bromide content (mean = 1,860 ppm) of the water indicates that they originated from evaporating seawater. They probably are related genetically to the Salina evaporite group. Calculations show that several subsequent diagenetic reactions can account for the observed major ion composition. Recrystallization of aragonite and dolomitization of calcite probably occurred as the waters moved through the big Lime and/or the Packer Shell carbonates. Cation exchange and chlorite formation probably altered water composition during interaction with shales of the Cabot Head formation and within the Clinton. Minor constituents of the waters appear to be controlled by reactions with clays.

  18. Avenue of approach generation

    SciTech Connect

    Powell, D.R.; Storm, G.

    1988-01-01

    Los Alamos National Laboratory is conducting research on developing a dynamic planning capability within an Army corps level combat simulation. Central to this research is the development of a computer based ability to ''understand'' terrain and how it is used in military planning. Such a capability demands data structures that adequately represent terrain features used in the planning process. These features primarily relate to attributes of mobility and visibility. Mobility concepts are abstracted to networks of mobility corridors. Notions of visibility are, for the purposes of planning, incorporated into the definition of key terrain. Prior work at Los Alamos has produced algorithms to generate mobility corridors from digitized terrain data. Mobility corridors, by definition, are the building blocks for avenues of approach, and the latter are the context in which key terrain is defined. The purpose of this paper is to describe recent work in constructing avenues of approach, characterization of avenues using summary characteristics, and their role in military planning. 7 refs., 4 figs., 1 tab.

  19. SOLANO AVENUE ENTRANCE RAMP. NOTE SOLANO AVENUE OVERCROSSING AT LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOLANO AVENUE ENTRANCE RAMP. NOTE SOLANO AVENUE OVERCROSSING AT LEFT REAR AND CLOSED ACCESS RAMP BENEATH; PARK ROW BRIDGE AT CENTER REAR AND TUNNEL NO. 2. LOOKING 350°N - Arroyo Seco Parkway, Solano Avenue Underpass, Milepost 25.09, Los Angeles, Los Angeles County, CA

  20. VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. 2325 PIEDMONT (MRS. F.W. FISH HOUSE DESIGNED BY CHARLES S. KAISER, 1910. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  1. Geochemical constraints on the origin of dolomite in the Ordovician Trenton and Black River limestones, Albion-Scipio area, Michigan

    SciTech Connect

    Granath, V.C. )

    1991-03-01

    The Albion-Scipio and Stoney Point oil fields in south-central Michigan produce from porous, vuggy dolomite in long linear trends associated with faulting in otherwise tight limestones. {sup 87}Sr/{sup 86}Sr ratios for undolomitized limestones (0.70796-0.70824) fall within the range for Middle Ordovician seawater given by the Burke curve and indicate they have undergone little alteration since deposition. {sup 87}Sr/{sup 86}Sr ratios for the matrix and dolomite cements in the reservoir horizons (0.70834-0.70898) are more radiogenic and overlap the range in composition for Late Silurian seawater. Thus, dolomitization might have resulted from brines dominated by Silurian seawater components. Fluid inclusion geothermometry and oxygen isotope compositions of the dolomite indicate formation under maximum burial conditions. Average freezing temperatures are {minus}29C (n = 72) and {minus}36C (n=19), respectively, indicating fluids are calcium- and magnesium-rich brines. {delta}{sup 18}O and {delta}{sup 2}H compositions of fluids in fluid inclusions are similar to data for Michigan basin brines and suggest some interaction with heavy oxygen probably from siliciclastics. These data indicate dolomitization in the Albion-Scipio area occurred under burial conditions from hot brines dominated by a Late Silurian seawater component. The brine may have been slightly modified either through mixture with another basinal fluid or interactions with siliciclastics during its circulation in the basin.

  2. A Quantitative Real-Time PCR-Based Strategy for Molecular Evaluation of Nicotine Conversion in Burley Tobacco.

    PubMed

    Sun, Bo; Xue, Sheng-Ling; Zhang, Fen; Luo, Zhao-Peng; Wu, Ming-Zhu; Chen, Qing; Tang, Hao-Ru; Lin, Fu-Cheng; Yang, Jun

    2015-11-17

    Nornicotine production in Nicotiana tabacum is undesirable because it is the precursor of the carcinogen N'-nitrosonornicotine. In some individual burley tobacco plants, a large proportion of the nicotine can be converted to nornicotine, and this process of nicotine conversion is mediated primarily by enzymatic N-demethylation of nicotine which is controlled mainly by CYP82E4. Here we report a novel strategy based on quantitative real-time polymerase chain reaction (qPCR) method, which analyzed the ratio of nicotine conversion through examining the transcript level of CYP82E4 in burley leaves and do not need ethylene induction before detected. The assay was linear in a range from 1 × 10¹ to 1 × 10⁵ copies/mL of serially diluted standards, and also showed high specificity and reproducibility (93%-99%). To assess its applicability, 55 plants of burley cultivar Ky8959 at leaf maturing stage were analyzed, and the results were in accordance with those from gas chromatograph-mass spectrometry (GC-MS) method. Moreover, a linear correlation existed between conversion level and CYP82E4 transcript abundance. Taken together, the quantitative real-time PCR assay is standardized, rapid and reproducible for estimation of nicotine conversion level in vivo, which is expected to shed new light on monitoring of burley tobacco converter.

  3. Determination of free amino acids in burley tobacco by high performance liquid chromatography.

    PubMed

    Jing, Yanqiu; Zhang, Baolin; Yuan, Xiuxiu; Gao, Yuzhen; Lu, Ping; Wang, Weifeng; Xu, Min

    2016-01-01

    A reversed-phase high performance liquid chromatographic method was developed for determining free amino acids in burley tobacco. The test was done by OPA/3-mercaptopropionic acid as the pre-column derivatizing reagent. Chromatographic column was Elitte C(18) column (4.6 mm × 250 mm i.d., 5 μm). Mobile phase A was 18 mol/l NaAc (pH7.2) including 0.002%(v/v) triethylamine and 0.3%(v/v) furanidine. Mobile phase B was 100 mol/l NaAc (pH7.2)-acetonitrile-methanol (v/v = 1:2:2). The column temperature was 40 °C and the flow rate was 1.0 ml/min. The fluorescence detector was used with 350 nm excitation wave length and 450 nm emission wave length. The average recoveries of the method ranged from 95.3-100.7% with the relative standard deviation of 2.32-9.24%. The method is simple, accurate and has good repeatability. The results of the determination of seventeen kinds of free amino acids in burley leaves were produced by the way of different ratios of cake fertilizer and inorganic fertilizer. The results show that Aspartic acid has the highest content however ratio of cake fertilizer and inorganic fertilizer. The contents of most of the free amino acids are increased and then gradually decreased with the increase in organic manure. The contents of most of the free amino acids are very close at 15:85% ratio and 30:70% ratio of cake fertilizer and inorganic fertilizer. The total amount of free amino acids is the highest at 30:70% ratio of cake fertilizer and inorganic fertilizer. Considering comprehensively, the quality of burley leaves is the best at 30:70% ratio of cake fertilizer and inorganic fertilizer.

  4. Determination of free amino acids in burley tobacco by high performance liquid chromatography

    PubMed Central

    Jing, Yanqiu; Zhang, Baolin; Yuan, Xiuxiu; Gao, Yuzhen; Lu, Ping; Wang, Weifeng; Xu, Min

    2015-01-01

    A reversed-phase high performance liquid chromatographic method was developed for determining free amino acids in burley tobacco. The test was done by OPA/3-mercaptopropionic acid as the pre-column derivatizing reagent. Chromatographic column was Elitte C18 column (4.6 mm × 250 mm i.d., 5 μm). Mobile phase A was 18 mol/l NaAc (pH7.2) including 0.002%(v/v) triethylamine and 0.3%(v/v) furanidine. Mobile phase B was 100 mol/l NaAc (pH7.2)–acetonitrile–methanol (v/v = 1:2:2). The column temperature was 40 °C and the flow rate was 1.0 ml/min. The fluorescence detector was used with 350 nm excitation wave length and 450 nm emission wave length. The average recoveries of the method ranged from 95.3–100.7% with the relative standard deviation of 2.32–9.24%. The method is simple, accurate and has good repeatability. The results of the determination of seventeen kinds of free amino acids in burley leaves were produced by the way of different ratios of cake fertilizer and inorganic fertilizer. The results show that Aspartic acid has the highest content however ratio of cake fertilizer and inorganic fertilizer. The contents of most of the free amino acids are increased and then gradually decreased with the increase in organic manure. The contents of most of the free amino acids are very close at 15:85% ratio and 30:70% ratio of cake fertilizer and inorganic fertilizer. The total amount of free amino acids is the highest at 30:70% ratio of cake fertilizer and inorganic fertilizer. Considering comprehensively, the quality of burley leaves is the best at 30:70% ratio of cake fertilizer and inorganic fertilizer. PMID:26858568

  5. Syn-extensional plutonism and peak metamorphism in the albion-raft river-grouse creek metamorphic core complex

    USGS Publications Warehouse

    Strickland, A.; Miller, E.L.; Wooden, J.L.; Kozdon, R.; Valley, J.W.

    2011-01-01

    The Cassia plutonic complex (CPC) is a group of variably deformed, Oligocene granitic plutons exposed in the lower plate of the Albion-Raft River- Grouse Creek (ARG) metamorphic core complex of Idaho and Utah. The plutons range from granodiorite to garnet-bearing, leucogranite, and during intrusion, sillimanite- grade peak metamorphism and ductile attenuation occurred in the country rocks and normal-sense, amphibolite-grade deformation took place along the Middle Mountain shear zone. U-Pb zircon geochronology from three variably deformed plutons exposed in the lower plate of the ARG metamorphic core complex revealed that each zircon is comprised of inherited cores (dominantly late Archean) and Oligocene igneous overgrowths. Within each pluton, a spread of concordant ages from the Oligocene zircon overgrowths is interpreted as zircon recycling within a long-lived magmatic system. The plutons of the CPC have very low negative whole rock ??Nd values of -26 to -35, and initial Sr values of 0.714 to 0.718, consistent with an ancient, crustal source. Oxygen isotope ratios of the Oligocene zircon overgrowths from the CPC have an average ??18O value of 5.40 ?? 0.63 permil (2SD, n = 65) with a slight trend towards higher ??18O values through time. The ??18O values of the inherited cores of the zircons are more variable at 5.93 ?? 1.51 permil (2SD, n = 29). Therefore, we interpret the plutons of the CPC as derived, at least in part, from melting Archean crust based on the isotope geochemistry. In situ partial melting of the exposed Archean basement that was intruded by the Oligocene plutons of the CPC is excluded as the source for the CPC based on field relationships, age and geochemistry. Correlations between Ti and Hf concentrations in zircons from the CPC suggest that the magmatic system may have become hotter (higher Ti concentration in zircon) and less evolved (lower Hf in zircon concentration) through time. Therefore, the CPC represents prolonged or episodic magmatism

  6. View of the Warrington Avenue Bridge portal, inbound from Pittsburgh ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the Warrington Avenue Bridge portal, inbound from Pittsburgh - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  7. View of the Warrington Avenue Bridge portal, outbound from Pittsburgh ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the Warrington Avenue Bridge portal, outbound from Pittsburgh - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  8. Elevation of Warrington Avenue Bridge and cut stone retaining wall ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation of Warrington Avenue Bridge and cut stone retaining wall southbound on Warrington Avenue - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  9. 43. 253255 AUBURN AVENUE (Jim's Place; Unisex Beauty Shop) NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    43. 253-255 AUBURN AVENUE (Jim's Place; Unisex Beauty Shop) NORTH ELEVATION 44. --- PIEDMONT AVENUE (Pucker House) EAST ELEVATION - 126-255 Auburn Avenue (Commercial Buildings), Auburn Avenue, Atlanta, Fulton County, GA

  10. General view of McClellan Avenue from intersection with Black Avenue, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General view of McClellan Avenue from intersection with Black Avenue, looking northeast - Southern Branch of the National Home for Disabled Volunteer Soldiers , 100 Emancipation Drive, Hampton, Hampton, VA

  11. Alternative splicing of basic chitinase gene PR3b in the low-nicotine mutants of Nicotiana tabacum L. cv. Burley 21

    PubMed Central

    Ma, Haoran; Wang, Feng; Wang, Wenjing; Yin, Guoying; Zhang, Dingyu; Ding, Yongqiang; Timko, Michael P.; Zhang, Hongbo

    2016-01-01

    Two unlinked semi-dominant loci, A (NIC1) and B (NIC2), control nicotine and related alkaloid biosynthesis in Burley tobaccos. Mutations in either or both loci (nic1 and nic2) lead to low nicotine phenotypes with altered environmental stress responses. Here we show that the transcripts derived from the pathogenesis-related (PR) protein gene PR3b are alternatively spliced to a greater extent in the nic1 and nic2 mutants of Burley 21 tobacco and the nic1nic2 double mutant. The alternative splicing results in a deletion of 65 nucleotides and introduces a premature stop codon into the coding region of PR3b that leads to a significant reduction of PR3b specific chitinase activity. Assays of PR3b splicing in F2 individuals derived from crosses between nic1 and nic2 mutants and wild-type plants showed that the splicing phenotype is controlled by the NIC1 and NIC2 loci, even though NIC1 and NIC2 are unlinked loci. Moreover, the transcriptional analyses showed that the splicing patterns of PR3b in the low-nicotine mutants were differentially regulated by jasmonate (JA) and ethylene (ET). These data suggest that the NIC1 and NIC2 loci display differential roles in regulating the alternative splicing of PR3b in Burley 21. The findings in this study have provided valuable information for extending our understanding of the broader effects of the low-nicotine mutants of Burley 21 and the mechanism by which JA and ET signalling pathways post-transcriptionally regulate the activity of PR3b protein. PMID:27664270

  12. Contextual view of building 47 looking across Walnut Avenue, with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 47 looking across Walnut Avenue, with building 521 in foreground; camera facing northeast. - Mare Island Naval Shipyard, Old Administrative Offices, Eighth Street, north side between Railroad Avenue & Walnut Avenue, Vallejo, Solano County, CA

  13. Contextual view of building 47 looking across Walnut Avenue, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 47 looking across Walnut Avenue, showing south elevation; camera facing northwest. - Mare Island Naval Shipyard, Old Administrative Offices, Eighth Street, north side between Railroad Avenue & Walnut Avenue, Vallejo, Solano County, CA

  14. Contextual view looking down California Avenue, showing south and east ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view looking down California Avenue, showing south and east elevations; camera facing northwest. - Mare Island Naval Shipyard, Central Power Plant, California Avenue, norhtwest corner of California Avenue & Seventh Street, Vallejo, Solano County, CA

  15. Contextual view of building 253 looking down Walnut Avenue, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 253 looking down Walnut Avenue, showing south elevation at right; camera facing north. - Mare Island Naval Shipyard, Supply Building, Walnut Avenue, southeast corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  16. Contextual view looking down railroad avenue with building 680 at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view looking down railroad avenue with building 680 at left and building 390 at right; camera facing south. - Mare Island Naval Shipyard, Machine Shop, California Avenue, southwest corner of California Avenue & Thirteenth Street, Vallejo, Solano County, CA

  17. 1. LOOKING EAST FROM 127125 JACKSON AVENUE (INDUSTRIAL COLLOIDS AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. LOOKING EAST FROM 127-125 JACKSON AVENUE (INDUSTRIAL COLLOIDS AND CHEMICALS, INC.) TO SULLIVAN'S SALOON (in background, with domed roof) - Jackson Avenue Warehouse District, 101-131 & 120-122 Jackson Avenue, Knoxville, Knox County, TN

  18. Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  19. Contextual view of building 733 along Cedar Avenue; camera facing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 733 along Cedar Avenue; camera facing southwest. - Mare Island Naval Shipyard, WAVES Officers Quarters, Cedar Avenue, west side between Tisdale Avenue & Eighth Street, Vallejo, Solano County, CA

  20. PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE AVENUE IN CENTER, AND FORD PIQIETTE PLANT ON THE OTHER SIDE. (Duplicate color view of HAER MI-349-1) - 411 Piquette Avenue (Industrial), Detroit, MI

  1. View southwest toward Eldred Avenue from within Friend's Burial Ground, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View southwest toward Eldred Avenue from within Friend's Burial Ground, Benjamin Carr Farm in distance through the trees - Friends' Burial Ground, Eldred & Beacon Avenues, Jamestown, Newport County, RI

  2. 3. HISTORIC PHOTOGRAPH, VIEW TO GRUMMAN AVENUE BRIDGE, CA. COLLECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. HISTORIC PHOTOGRAPH, VIEW TO GRUMMAN AVENUE BRIDGE, CA. COLLECTION CONNECTICUT DEPARTMENT OF TRANSPORTATION. - Merritt Parkway, Grumman Avenue Bridge, Spanning Merritt Parkway, Norwalk, Fairfield County, CT

  3. 6. HISTORIC PHOTOGRAPH, VIEW TO GRUMMAN AVENUE BRIDGE, CA. 1940. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. HISTORIC PHOTOGRAPH, VIEW TO GRUMMAN AVENUE BRIDGE, CA. 1940. COLLECTION CONNECTICUT DEPARTMENT OF TRANSPORTATION. - Merritt Parkway, Grumman Avenue Bridge, Spanning Merritt Parkway, Norwalk, Fairfield County, CT

  4. Microscopy Opening Up New Cancer Discovery Avenues

    Cancer.gov

    Today’s high-powered microscopes are allowing researchers to study the fine details of individual cells and to peer into cells, opening up new avenues of discovery about the inner workings of cells, including the events that can cause healthy cells to tra

  5. Shallow ground-water quality adjacent to burley tobacco fields in northeastern Tennessee and southwestern Virginia, spring 1997

    USGS Publications Warehouse

    Johnson, G.C.; Connell, J.F.

    2001-01-01

    In 1994, the U.S. Geological Survey began an assessment of the upper Tennessee River Basin as part of the National Water-Quality Assessment (NAWQA) Program. A ground-water land-use study conducted in 1996 focused on areas with burley tobacco production in northeastern Tennessee and southwestern Virginia. Land-use studies are designed to focus on specific land uses and to examine natural and human factors that affect the quality of shallow ground water underlying specific types of land use. Thirty wells were drilled in shallow regolith adjacent to and downgradient of tobacco fields in the Valley and Ridge Physiographic Province of the upper Tennessee River Basin. Ground-water samples were collected between June 4 and July 9, 1997, to coincide with the application of the majority of pesticides and fertilizers used in tobacco production. Ground-water samples were analyzed for nutrients, major ions, 79 pesticides, 7 pesticide degradation products, 86 volatile organic compounds, and dissolved organic carbon. Nutrient concentrations were lower than the levels found in similar NAWQA studies across the United States during 1993-95. Five of 30 upper Tennessee River Basin wells (16.7 percent) had nitrate levels exceeding 10 mg/L while 19 percent of agricultural land-use wells nationally and 7.9 percent in the Southeast had nitrate concentrations exceeding 10 mg/L. Median nutrient concentrations were equal to or less than national median concentrations. All pesticide concentrations in the basin were less than established drinking water standards, and pesticides were detected less frequently than average for other NAWQA study units. Atrazine was detected at 8 of 30 (27 percent) of the wells, and deethylatrazine (an atrazine degradation product) was found in 9 (30 percent) of the wells. Metalaxyl was found in 17 percent of the wells, and prometon, flumetralin, dimethomorph, 2,4,5-T, 2,4-D, dichlorprop, and silvex were detected once each (3 percent). Volatile organic compounds

  6. The timing of tertiary metamorphism and deformation in the Albion-Raft River-Grouse Creek metamorphic core complex, Utah and Idaho

    USGS Publications Warehouse

    Strickland, A.; Miller, E.L.; Wooden, J.L.

    2011-01-01

    The Albion-Raft River-Grouse Creek metamorphic core complex of southern Idaho and northern Utah exposes 2.56-Ga orthogneisses and Neoproterozoic metasedimentary rocks that were intruded by 32-25-Ma granitic plutons. Pluton emplacement was contemporaneous with peak metamorphism, ductile thinning of the country rocks, and top-to-thewest, normal-sense shear along the Middle Mountain shear zone. Monazite and zircon from an attenuated stratigraphic section in the Middle Mountain were dated with U-Pb, using a SHRIMP-RG (reverse geometry) ion microprobe. Zircons from the deformed Archean gneiss preserve a crystallization age of 2532 ?? 33 Ma, while monazites range from 32.6 ?? 0.6 to 27.1 ?? 0.6 Ma. In the schist of the Upper Narrows, detrital zircons lack metamorphic overgrowths, and monazites produced discordant U-Pb ages that range from 52.8 ?? 0.6 to 37.5 ?? 0.3 Ma. From the structurally and stratigraphically highest unit sampled, the schist of Stevens Spring, narrow metamorphic rims on detrital zircons yield ages from 140-110 Ma, and monazite grains contained cores that yield an age of 141 ??2 Ma, whereas rims and some whole grains ranged from 35.5 ?? 0.5 to 30.0 ?? 0.4 Ma. A boudinaged pegmatite exposed in Basin Creek is deformed by the Middle Mountains shear zone and yields a monazite age of 27.6 ?? 0.2 Ma. We interpret these data to indicate two periods of monazite and metamorphic zircon growth: a poorly preserved Early Cretaceous period (???140 Ma) that is strongly overprinted by Oligocene metamorphism (???32-27 Ma) related to regional plutonism and extension. ?? 2011 by The University of Chicago.

  7. Cedar Creek at Cedartown, Georgia, floodflow characteristics from West Girard Avenue to the Georgia Avenue Relocation

    USGS Publications Warehouse

    Price, McGlone

    1981-01-01

    In cooperation with the Highway Division, Georgia Department of Transportation, the U.S. Geological Survey determined the backwater effects of existing bridges and dikes on Cedar Creek at Cedartown, Georgia, for the reach from West Girard Avenue to the Georgia Avenue relocation. The maximum backwater effect for the bridges was 1.7 feet in the upstream approach at the Seaboard Coastline Railroad bridge as a combined result of the Georgia Highway 278 bridge and the Seaboard Coastline Railroad bridge. The maximum effect from the existing dikes was 0.7 foot at the approach section of Georgia Highway 278.

  8. 13. Tenth Avenue grade separation: south side with elevator no. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Tenth Avenue grade separation: south side with elevator no. 2 and track shed to left, facing north-northwest - Washburn Crosby Company Elevators No. 2 & 3, 900 & 1000 Second Avenue, South, Minneapolis, Hennepin County, MN

  9. CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE; CAMERA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE; CAMERA FACING SOUTH - Mare Island Naval Shipyard, Bachelor Enlisted Quarters & Offices, Walnut Avenue, east side between D Street & C Street, Vallejo, Solano County, CA

  10. CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE, SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE, SHOWING WEST ELEVATION. CAMERA FACING SOUTH - Mare Island Naval Shipyard, Bachelor Enlisted Quarters & Offices, Walnut Avenue, east side between D Street & C Street, Vallejo, Solano County, CA

  11. 23. Surrender interview site, showing Pemberton Avenue concrete slab road ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Surrender interview site, showing Pemberton Avenue concrete slab road type with gutter (asphalt construction typical on Union and Confederate Avenues), view to the sw. - Vicksburg National Military Park Roads & Bridges, Vicksburg, Warren County, MS

  12. 1. View southeast from Eldred Avenue toward stone wall at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View southeast from Eldred Avenue toward stone wall at corner of Benjamin Carr Farm. Wall moved to current location in 1941-1942. - Benjamin Carr Farm, Route 138 (Eldred Avenue) & Helm Street, Jamestown, Newport County, RI

  13. 3. View facing southeast from Kinsley Avenue, showing a threequarter ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. View facing southeast from Kinsley Avenue, showing a three-quarter view of the facade (north elevation) and west elevation. - Terminal Building, 184 Kinsley Avenue & 11-25 Terminal Way, Providence, Providence County, RI

  14. 2. View facing west from Kinsley Avenue, showing a threequarter ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. View facing west from Kinsley Avenue, showing a three-quarter view of the facade (north elevation) and east elevation. - Terminal Building, 184 Kinsley Avenue & 11-25 Terminal Way, Providence, Providence County, RI

  15. 72. 451 MADISON AVENUE, GRAND STAIR, ZODIAC CLOCK WITH DECORATIVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. 451 MADISON AVENUE, GRAND STAIR, ZODIAC CLOCK WITH DECORATIVE CARVING BY STANFORD WHITE AND AUGUSTUS SAINT-GAUDENS - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  16. Contextual view of building 505 Cedar avenue, showing south and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 505 Cedar avenue, showing south and east elevations; camera facing northwest. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  17. View of east elevation along California Avenue; camera facing west. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of east elevation along California Avenue; camera facing west. - Mare Island Naval Shipyard, Rubber Shop, California Avenue, west side across from Dry Dock 1 near Ninth Street, Vallejo, Solano County, CA

  18. 88. 451 MADISON AVENUE, LIBRARY, SOUTH WALL, WEST CENTRAL SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    88. 451 MADISON AVENUE, LIBRARY, SOUTH WALL, WEST CENTRAL SECTION SHOWING WINDOW AND RADIATOR (Pair with NY-5635-89) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  19. 60. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, WEST MURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, WEST MURAL PAINTING SHOWING A WOMAN (See NY-5635-54 for original location) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  20. VIEW SOUTHWEST FROM NEW YORK AVENUE, SHOWING NORTH WALL OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTHWEST FROM NEW YORK AVENUE, SHOWING NORTH WALL OF STRAW STORAGE BUILDING AND NORTH AND WEST SIDES OF MANUFACTURING BUILDING - Enterprise Pottery, 650 New York Avenue, Trenton, Mercer County, NJ

  1. 8. 451 MADISON AVENUE, MAIN HALL, SOUTH WALL, MOSAIC TYMPANUM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. 451 MADISON AVENUE, MAIN HALL, SOUTH WALL, MOSAIC TYMPANUM OF THREE FIGURES IN BOLD RELIEF ABOVE FIREPLACE - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  2. 1. Building 8 south elevation oblique along Ridge Avenue. View ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Building 8 south elevation oblique along Ridge Avenue. View looking east. - John & James Dobson Carpet Mill (West Parcel), Building No. 8, 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  3. 1. Building 7 south elevation oblique along Ridge Avenue. View ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Building 7 south elevation oblique along Ridge Avenue. View looking east. - John & James Dobson Carpet Mill (West Parcel), Building No. 7, 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  4. 1. General view, corner of Ridge Avenue and Crawford Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. General view, corner of Ridge Avenue and Crawford Street. Building 10 shown center. View looking east. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  5. 6. IRON FENCE SEPARATING GRAY'S FERRY AVENUE AND NAVAL GROUNDS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. IRON FENCE SEPARATING GRAY'S FERRY AVENUE AND NAVAL GROUNDS. FENCE IS ORIGINAL--NOTE GREEK ACROTERIANS. - U. S. Naval Asylum, Biddle Hall, Gray's Ferry Avenue, Philadelphia, Philadelphia County, PA

  6. Close view of the south facade on Constitution Avenue to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close view of the south facade on Constitution Avenue to show main entrance - United States Department of Justice, Constitution Avenue between Ninth & Tenth Streets, Northwest, Washington, District of Columbia, DC

  7. Guideway along Frankford Avenue between Dyre Street and Pratt Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Guideway along Frankford Avenue between Dyre Street and Pratt Street. Looking northeast. Pratt Street station in right mid-ground. - Frankford Elevated, 52100-5400 Frankford Avenue (guideway & stations), Philadelphia, Philadelphia County, PA

  8. VIEW OF BUILDING 10, NORTH SIDE ON PRATT AVENUE, FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF BUILDING 10, NORTH SIDE ON PRATT AVENUE, FACING SOUTH - Roosevelt Base, Fleet Landing Building, Bounded by Richardson & Pratt Avenues, Maryland & West Virginia Streets, Long Beach, Los Angeles County, CA

  9. EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCIUS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCI-US STEEL 'DOUBLE THREE ROOM' COMPANY HOUSE BUILT FOR BLACK ORE MINERS AND THEIR FAMILIES DURING WORLD WAR I. - New Village Worker Houses, New Avenue, Bessemer, Jefferson County, AL

  10. EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCIUS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCI-US STEEL "DOUBLE THREE ROOM" COMPANY HOUSE BUILT FOR BLACK ORE MINERS AND THEIR FAMILIES DURING WORLD WAR I - New Village Worker Houses, New Avenue, Bessemer, Jefferson County, AL

  11. Interior showing both 425 and 427 North Miami Avenue, view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior showing both 425 and 427 North Miami Avenue, view looking west, pressed tin ceiling in 425 North Miami is visible on the left - Chaille Commercial Building, 425-429 North Miami Avenue, Miami, Miami-Dade County, FL

  12. Perspective view looking along the Constitution Avenue facade, showing the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view looking along the Constitution Avenue facade, showing the twenty-seven bays and the three central arches that mark the entrance to the building - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

  13. Close view of the Constitution Avenue elevation to show arched ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close view of the Constitution Avenue elevation to show arched gateways and pedimented pavilion ("Commerce and Communication" sculpted pediment) - Interstate Commerce Commission, Constitution Avenue between Twelfth and Fourteenth streets, Washington, District of Columbia, DC

  14. 6. Corner of fieldstone wall at Towne Avenue (right side ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Corner of fieldstone wall at Towne Avenue (right side of photo) and Base Line Road (background). Decorative border is also shown. - Pitzer Ranch, Rock Wall, 4353 Towne Avenue, Claremont, Los Angeles County, CA

  15. 2. Fieldstone wall along Towne Avenue. Decorative fieldstone landscape border ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Fieldstone wall along Towne Avenue. Decorative fieldstone landscape border is shown. Pitzer-Peairs House is in the background. - Pitzer Ranch, Rock Wall, 4353 Towne Avenue, Claremont, Los Angeles County, CA

  16. Close Up View Of Vermont Avenue Streetscape, Looking North West, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close Up View Of Vermont Avenue Streetscape, Looking North West, Mary McLeod Bethune Council House National Historic Site Is The Second Door From The Left. - 1318 Vermont Avenue, Northwest (House), Washington, District of Columbia, DC

  17. 4. CLOSE UP VIEW OF VERMONT AVENUE STREETSCAPE, LOOKING NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. CLOSE UP VIEW OF VERMONT AVENUE STREETSCAPE, LOOKING NORTH WEST, MARY McLEOD BETHUNE HOUSE IS THE SECOND DOOR FROM THE LEFT. - 1318 Vermont Avenue, Northwest (House), Washington, District of Columbia, DC

  18. 46. Exterior view at the corner of Seventh Avenue and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Exterior view at the corner of Seventh Avenue and Olive Way, looking NE. Opening night film, 'The Broadway Melody,' displayed on the canopy marquee. - Fox Theater, Seventh Avenue & Olive Way, Seattle, King County, WA

  19. 2. VIEW OF SITE A FROM THORNE AVENUE, FACING NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF SITE A FROM THORNE AVENUE, FACING NORTHWEST. (BUILDINGS 120, 117, 121, 122, AND 129 ARE VISIBLE.) - Fort McPherson, World War II Station Hospital, Structures, Bordered by Hardee & Thorne Avenues & Howe Street, Atlanta, Fulton County, GA

  20. 10. Third Melan Bridge on tour route Union Avenue just ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Third Melan Bridge on tour route Union Avenue just beyond tour stop 6, detail from scaffold to the north. - Vicksburg National Military Park Roads & Bridges, Melan Arch Bridges, Spanning various tributaries at Confederate Avenue, Vicksburg, Warren County, MS

  1. VIEW OF 2328 PIEDMONT AVENUE, CHARLES MILLS GAYLEY HOUSE DESIGNED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF 2328 PIEDMONT AVENUE, CHARLES MILLS GAYLEY HOUSE DESIGNED BY JULIA MORGAN, 1905. SEEN FROM SIDEWALK LOOKING NW TOWARDS DURANT AVENUE. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  2. LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 AND 1041 (QUARTERS 1 AND J) AT LEFT. VIEW FACING SOUTHWEST. - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Hale Alii Avenue, Eighth Street, & Avenue D, Pearl City, Honolulu County, HI

  3. 2. AERIAL VIEW, LOOKING WEST, ALONG FIRST AVENUE NORTH, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. AERIAL VIEW, LOOKING WEST, ALONG FIRST AVENUE NORTH, WITH BROWN MARX BUILDING (BOTTOM CENTER TO RIGHT), EMPIRE BUILDING (CENTER TOP) WITH ITS TERRACOTTA-CLAD 20TH STREET AND FIRST AVENUE FACADES, AND JOHN HAND BUILDING - Heaviest Corner on Earth (Commercial), First Avenue, North & Twentieth (20th) Street, North, Birmingham, Jefferson County, AL

  4. View of Hinkley Avenue. Parking Area No. 7 on right, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue. Parking Area No. 7 on right, Building No. 8 on right and Building No. 9 on left. Looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  5. View of Foothill Avenue seen from Building No. 41. Buildings ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Foothill Avenue seen from Building No. 41. Buildings No. 41, 39, 37, 38, and 40 from left to right - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  6. View of Hinkley Avenue from former intersection with Hoffman Boulevard. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue from former intersection with Hoffman Boulevard. Note reconstructed Easter Hill Buildings No. 2, 3, and 4 from left to right at rear. Looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  7. View of Hinkley Avenue looking towards former intersection with Hoffman ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue looking towards former intersection with Hoffman Boulevard. Note former building site of Building No. 1 at right rear. Looking southwest - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  8. View of Hinkley Avenue at Hinkley Square intersection. Note reconstructed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue at Hinkley Square intersection. Note reconstructed Easter Hill Building No. 4 on left and Building No. 6 on right. Looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  9. View of Parking Area No. 32 from Foothill Avenue. Buildings ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Parking Area No. 32 from Foothill Avenue. Buildings No. 23, 24, 34, 25, and 35, from left to right. Looking south - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  10. View of Foothill Avenue. Buildings No. 40, 42, 44, 45, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Foothill Avenue. Buildings No. 40, 42, 44, 45, 41, and 39 seen from left to right. Note rolled curbing. Looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  11. View of Parking Area No. 11 on Hinkley Avenue. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Parking Area No. 11 on Hinkley Avenue. Building No. 14 at left. Looking southeast - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  12. SUBSTRUCTURE AND RAMP DETAIL VIEW OF FIRST AVENUE ON AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SUBSTRUCTURE AND RAMP DETAIL VIEW OF FIRST AVENUE ON- AND OFF-RAMPS, LOOKING SOUTHEAST AT FIRST AVENUE (DEARBORN AND RAILROAD AVENUES SOUTH INTERSECTION). NOTE STEEL AND CONCRETE GIRDERS AND CONCRETE COLUMNS. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

  13. 23. View of west side of South Coweta Avenue south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. View of west side of South Coweta Avenue south of East Ward Street, facing west. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  14. 24. View of west side of South Coweta Avenue south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. View of west side of South Coweta Avenue south of East Ward Street, facing northwest. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  15. 22. View of east side of South Gaskin Avenue at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. View of east side of South Gaskin Avenue at the intersection with East Ashley Street, facing east. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  16. Epigenetic mechanisms in migraine: a promising avenue?

    PubMed

    Eising, Else; A Datson, Nicole; van den Maagdenberg, Arn M J M; Ferrari, Michel D

    2013-01-01

    Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of histone proteins, affecting chromatin structure and gene expression. Besides playing a role in establishing cellular and developmental stage-specific regulation of gene expression, epigenetic processes are also important for programming lasting cellular responses to environmental signals. Epigenetic mechanisms may explain how non-genetic endogenous and exogenous factors such as female sex hormones, stress hormones and inflammation trigger may modulate attack frequency. Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine.

  17. Avenues for crowd science in Hydrology.

    NASA Astrophysics Data System (ADS)

    Koch, Julian; Stisen, Simon

    2016-04-01

    Crowd science describes research that is conducted with the participation of the general public (the crowd) and gives the opportunity to involve the crowd in research design, data collection and analysis. In various fields, scientists have already drawn on underused human resources to advance research at low cost, with high transparency and large acceptance of the public due to the bottom up structure and the participatory process. Within the hydrological sciences, crowd research has quite recently become more established in the form of crowd observatories to generate hydrological data on water quality, precipitation or river flow. These innovative observatories complement more traditional ways of monitoring hydrological data and strengthen a community-based environmental decision making. However, the full potential of crowd science lies in internet based participation of the crowd and it is not yet fully exploited in the field of Hydrology. New avenues that are not primarily based on the outsourcing of labor, but instead capitalize the full potential of human capabilities have to emerge. In multiple realms of solving complex problems, like image detection, optimization tasks, narrowing of possible solutions, humans still remain more effective than computer algorithms. The most successful online crowd science projects Foldit and Galaxy Zoo have proven that the collective of tens of thousands users could clearly outperform traditional computer based science approaches. Our study takes advantage of the well trained human perception to conduct a spatial sensitivity analysis of land-surface variables of a distributed hydrological model to identify the most sensitive spatial inputs. True spatial performance metrics, that quantitatively compare patterns, are not trivial to choose and their applicability is often not universal. On the other hand humans can quickly integrate spatial information at various scales and are therefore a trusted competence. We selected

  18. Promising avenues of therapeutics for bipolar illness

    PubMed Central

    Post, Robert M.

    2008-01-01

    Basic scientific advances in understanding the neuropsychobioloqy of bipolar disorder have given us a multitude of opportunities to explore and exploit new avenues of therapeutics. Pharmacotherapeutic approaches include: neuropeptides (agonists such as thyrotropin-releasing hormone and antagonists such as corticotropin-releasing hormone), neurotrophic factors (especially brain-derived neurotrophic factor), and glutamatergic mechanisms (such as riluzole, ketamine, and antagonists of the NR-2B subunit of the glutamate receptor). Physiological interventions that would offer alternatives to electroconvulsive therapy include: repeated transcranial magnetic stimulation, especially at more intense stimulation parameters; magnetic stimulation therapy (seizures induced more focally by magnetic rather than electrical stimulation with resulting reduced meaning loss); vagal nerve stimulation, and deep brain stimulation. However, these, as well as the panoply of existing treatments, require further intensive investigation to place each of them in the proper therapeutic seguence and combination for the individual patient, based on development of better clinical and biological predictors of response. Large clinical trial networks and development of systematic research in clinical practice settings, such as that featured by the National Cancer institute for cancer chemotherapy, would greatly accelerate the progress in incorporating new, as well as existing, agents into the best treatment strategies. The bipolar disorders, which are increasingly recognized as complex, highly comorbid conditions with a high morbidity and mortality, of which the majority start in childhood and adolescence, are not likely to respond completely to any single new treatment agent, and new public health initiatives and research strategies are needed as much as any new single treatment advance. PMID:18689289

  19. Promising avenues of therapeutics for bipolar illness.

    PubMed

    Post, Robert M

    2008-01-01

    Basic scientific advances in understanding the neuropsychobiology of bipolar disorder have given us a multitude of opportunities to explore and exploit new avenues of therapeutics. Pharmacotherapeutic approaches include: neuropeptides (agonists such as thyrotropin-releasing hormone and antagonists such as corticotropin-releasing hormone), neurotrophic factors (especially brain-derived neurotrophic factor), and glutamatergic mechanisms (such as riluzole, ketamine, and antagonists of the NR-2B subunit of the glutamate receptor). Physiological interventions that would offer alternatives to electroconvulsive therapy include: repeated transcranial magnetic stimulation, especially at more intense stimulation parameters; magnetic stimulation therapy (seizures induced more focally by magnetic rather than electrical stimulation with resulting reduced meaning loss); vagal nerve stimulation, and deep brain stimulation. However, these, as well as the panoply of existing treatments, require further intensive investigation to place each of them in the proper therapeutic sequence and combination for the individual patient, based on development of better clinical and biological predictors of response. Large clinical trial networks and development of systematic research in clinical practice settings, such as that featured by the National Cancer Institute for cancer chemotherapy, would greatly accelerate the progress in incorporating new, as well as existing, agents into the best treatment strategies. The bipolar disorders, which are increasingly recognized as complex, highly comorbid conditions with a high morbidity and mortality, of which the majority start in childhood and adolescence, are not likely to respond completely to any single new treatment agent, and new public health initiatives and research strategies are needed as much as any new single treatment advance.

  20. 12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING DEVELOPMENT. 'BURBANK FARM' ON RIGHT. TALL TREE TO RIGHT OF STREET LIGHT IS EUCALYPTUS ON WEST OF COTTAGE WHICH IS PLANNED FOR REMOVAL. 13. 'BURBANK FARM' SHOWING BANK CUT CREATED WHEN BODEGA AVENUE ROADBED WAS LOWERED. WPA STONE RETAINING WALL AT BASE OF CUT. LOOKING SOUTHWEST. - Gold Ridge Farm, 7777 Bodega Avenue, Sebastopol, Sonoma County, CA

  1. Management engineering (building no. 4), looking west along Porter Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Management engineering (building no. 4), looking west along Porter Avenue. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  2. 4. Passaic River looking northwest from Ackerman Avenue bridge; Dundee ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Passaic River looking northwest from Ackerman Avenue bridge; Dundee Textile Company Mill at left - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

  3. VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. NOTE OAK GROVE AND UNIVERSITY OF CALIFORNIA FOOTBALL STADIUM AT RIGHT REAR. NOTE STAIRCASE IN MEDIAN. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  4. View from Western Avenue looking northwest down curbside walkway. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View from Western Avenue looking northwest down curbside walkway. Building 15 in left foreground. Illustration of asymmetrical layout and forty-five degree angle of buildings to public street - Harbor Hills Housing Project, 26607 Western Avenue, Lomita, Los Angeles County, CA

  5. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY VIEW OF 2401 PIEDMONT, ALPHA EPSILON PHI HOUSE BY RATCLIFF & RATCLIFF, 1958. SEEN FROM NW CORNER LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  6. VIEW FROM CENTER OF ELM AVENUE, LOOKING WEST INTO SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FROM CENTER OF ELM AVENUE, LOOKING WEST INTO SECTION L. AT LEFT STANDS THE PONDEROUS MCDANIEL MAUSOLEUM, WHICH SHOWS THE INFLUENCE OF FRANK FURNESS ON H. Q. FRENCH’S 1887 DESIGN - Woodlands Cemetery, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

  7. VIEW FACING EAST ON DONNER AVENUE WITH CONVEYOR LEADING TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FACING EAST ON DONNER AVENUE WITH CONVEYOR LEADING TO COKE PLANT TO THE LEFT. REMAINS OF BASIC OXYGEN FURNACE IN CENTER BACKGROUND AND CHURCH ON SCHOONMAKER STREET TO THE RIGHT. - Pittsburgh Steel Company, Monessen Works, Donner Avenue, Monessen, Westmoreland County, PA

  8. Looking west along Railroad Avenue toward the Fire House, visible ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking west along Railroad Avenue toward the Fire House, visible in the center distance, behind the left Sentry House. The historic Marine Barracks (Building 930) is also visible at the far left, and Building 1296 in the right distance - Mare Island Naval Shipyard, South Fire Station, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

  9. View of southwest elevation of Building No. 42. Foothill Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of southwest elevation of Building No. 42. Foothill Avenue in foreground, seen from yard of Building No. 41, Building No. 44 at rear. Looking northeast - Easter Hill Village, Building No. 42, Northwest corner of Foothill Avenue & South Twenty-eighth Street, Richmond, Contra Costa County, CA

  10. 59. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, CENTRAL MURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    59. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, CENTRAL MURAL PAINTING SHOWING WOMAN ON A SWING (See NY-5635-54 for original location) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  11. 3. VIEW OF CENTRAL AVENUE LOOKING WEST FROM JUST EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF CENTRAL AVENUE LOOKING WEST FROM JUST EAST OF THE INTERSECTION OF CENTRAL AVENUE AND THE EAST PERIMETER ROAD. THE ROCKY FLATS PLANT IS ABOUT 16 MILES NORTHWEST OF DENVER ON A PLATEAU AT THE EASTERN EDGE OF THE FRONT RANGE OF THE ROCKY MOUNTAINS. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  12. 1. 319 EAST COMMERCIAL AVENUE IS THE SINGLE STORY BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 319 EAST COMMERCIAL AVENUE IS THE SINGLE STORY BUILDING IN THE CENTER OF THE PHOTOGRAPH. IT IS DISTINGUISHED BY ITS CAST METAL FACADE WITH WOODEN INLAY, AND THE PRESSED METAL CORNICE AT THE PARAPET WALL - Anaconda Historic District, 319 East Commercial Avenue, Anaconda, Deer Lodge County, MT

  13. 2. Building 7 west elevation oblique from Ridge Avenue, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Building 7 west elevation oblique from Ridge Avenue, showing entrance to complex between Building 7 (right) and Building 8 (left). View looking NE. - John & James Dobson Carpet Mill (West Parcel), Building No. 7, 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  14. Context view from intersection of Assiniboine Avenue and H Street ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context view from intersection of Assiniboine Avenue and H Street showing building No. 61 in alignment of government houses, view to north - Fort Peck Indian Boarding School, Employee's Quarters, Northwest corner of Assiniboine Avenue and H Street, Poplar, Roosevelt County, MT

  15. 2. VIEW NORTHWEST FROM NINTH AVENUE (Compare with HABS NO. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW NORTHWEST FROM NINTH AVENUE (Compare with HABS NO. WI-308-89, taken in 1943.) - Fort McCoy, Building No. T-1065, Northeast of Intersection of South Ninth Avenue & South "Y" Street, Block 10, Sparta, Monroe County, WI

  16. DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM EAST SIDE OF CIRCLE LOOKING NORTH AT 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  17. VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. SEEN FROM WEST SIDE OF PIEDMONT AVE. LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 8, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  18. VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. INTERSECTION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. INTERSECTION OF HASTE STREET SEEN AT CENTER DISTANCE. SEEN FROM WEST SIDE OF PIEDMONT AVE. LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 8, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  19. LOOKING WNW, CHEVROLET AVENUE BRIDGE CROSSING FLINT RIVER. BRIDGE CONNECTED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING WNW, CHEVROLET AVENUE BRIDGE CROSSING FLINT RIVER. BRIDGE CONNECTED NORTH AND SOUTH PORTIONS OF FACTORY COMPLEX. DANIEL LUTEN DESIGNED THE BRIDGE, AND ILLINOIS BRIDGE COMPANY BUILT IT IN 1918. THE BRIDGE WAS THE SITE OF THE BATTLE OF RUNNING BULLS IN THE 1936-1937 GM SIT DOWN STRIKE. - Delphi Flint West, 300 Chevrolet Avenue, Flint, Genesee County, MI

  20. 9. ACCESS ROAD FOR NORTHBOUND PARKWAY LANES AT AVENUE 60. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. ACCESS ROAD FOR NORTHBOUND PARKWAY LANES AT AVENUE 60. NOTE RAILING AT LEFT FOR BRIDGE SEEN IN CA-265-T-8. LOOKING 308°N. - Arroyo Seco Parkway, Avenue 60 Bridge, Milepost 28.76, Los Angeles, Los Angeles County, CA

  1. 15. Fifth Melan Bridge on tour route, Union Avenue near ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Fifth Melan Bridge on tour route, Union Avenue near Park Boundary, deck view to the north. (bridge has now been replaced with box culvert.) - Vicksburg National Military Park Roads & Bridges, Melan Arch Bridges, Spanning various tributaries at Confederate Avenue, Vicksburg, Warren County, MS

  2. 16. Fifth Melan Bridge on tour route, Union Avenue near ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Fifth Melan Bridge on tour route, Union Avenue near Park Boundary, closer view of surface showing cracks, view to the south. - Vicksburg National Military Park Roads & Bridges, Melan Arch Bridges, Spanning various tributaries at Confederate Avenue, Vicksburg, Warren County, MS

  3. 14. Fifth Melan Bridge on tour route, Union Avenue near ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Fifth Melan Bridge on tour route, Union Avenue near Park Boundary, elevation view to the north, showing Culvert beyond park boundary. (bridge has now been replaced with box culvert). - Vicksburg National Military Park Roads & Bridges, Melan Arch Bridges, Spanning various tributaries at Confederate Avenue, Vicksburg, Warren County, MS

  4. 2. HISTORIC PHOTOGRAPH, VIEW ALONG NEW CANAAN AVENUE TO MERRITT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. HISTORIC PHOTOGRAPH, VIEW ALONG NEW CANAAN AVENUE TO MERRITT PARKWAY BRIDGE, CA. 1940. COLLECTION CONNECTICUT DEPARTMENT OF TRANSPORTATION. - Merritt Parkway, New Canaan Road/Route 123 Bridge, Spanning New Canaan Road/Route 123, Norwalk, Fairfield County, CT

  5. 17. View of Park Avenue to north across the San ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. View of Park Avenue to north across the San Francisco River. AZ-195 (Arizona Copper Company Manager's House) at right - Clifton Townsite, Confluence of Chase Creek & San Francisco River, Clifton, Greenlee County, AZ

  6. 19. Courtland Avenue Bridge. Stamford, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Courtland Avenue Bridge. Stamford, Fairfield Co., CT. Sec. 9108, MP 35.21. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  7. 75. Blatchley Avenue Bridge. New Haven, New Haven Co., CT. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    75. Blatchley Avenue Bridge. New Haven, New Haven Co., CT. Sec. 4209, MP 74.18. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  8. 39. Fairfield Avenue Bridge. Bridgeport, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. Fairfield Avenue Bridge. Bridgeport, Fairfield Co., CT. Sec. 9108, MP 55.68. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  9. 22. WEST CONFEDERATE AVENUE BRIDGE SPANNING SPANGLER'S RUN. NOTE MORE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. WEST CONFEDERATE AVENUE BRIDGE SPANNING SPANGLER'S RUN. NOTE MORE RANDOM ASHLAR COURSING AND ARCH TO PARAPET. BRIDGE WAS WIDENED BY NPS USING CCC LABOR. VIEW SSE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  10. Unit 3, downstream from Fourth Avenue Bridge Johnstown Local ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Unit 3, downstream from Fourth Avenue Bridge - Johnstown Local Flood Protection Project, Beginning on Conemaugh River approx 3.8 miles downstream from confluence of Little Conemaugh & Stony Creek Rivers at Johnstown, Johnstown, Cambria County, PA

  11. 2. AERIAL VIEW OF ROLLING LIFT BRIDGE. DORCHESTER AVENUE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. AERIAL VIEW OF ROLLING LIFT BRIDGE. DORCHESTER AVENUE IN BACKGROUND. SOUTH STATION VISIBLE AT TOP LEFT. - New York, New Haven & Hartford Railroad, Fort Point Channel Rolling Lift Bridge, Spanning Fort Point Channel, Boston, Suffolk County, MA

  12. 28. Yards north of Branch Avenue Bridge. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Yards north of Branch Avenue Bridge. Providence, Providence Co., RI. Sec. 4116, mp 186.25. - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  13. 27. Yards north of Branch Avenue Bridge. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Yards north of Branch Avenue Bridge. Providence, Providence Co., RI. Sec. 4116, mp 186.25. - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  14. 74. AERIAL VIEW OF MEMORIAL BRIDGE AND MEMORIAL AVENUE LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    74. AERIAL VIEW OF MEMORIAL BRIDGE AND MEMORIAL AVENUE LOOKING EAST AT LINCOLN MEMORIAL. - George Washington Memorial Parkway, Along Potomac River from McLean to Mount Vernon, VA, Mount Vernon, Fairfax County, VA

  15. 9. REYNOLDS AVENUE BRIDGE, ROAD VIEW. NOTE THE GRADE RISES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. REYNOLDS AVENUE BRIDGE, ROAD VIEW. NOTE THE GRADE RISES OVER TRACKS DUE TO INCREASED LOCOMOTIVE SIZES. SEVERAL MONUMENTS WERE MOVED TO FACILITATE THIS. VIEW NE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  16. 15. MEREDITH AVENUE, VIEW WITH LOG RAIL AND BARN. PERHAPS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. MEREDITH AVENUE, VIEW WITH LOG RAIL AND BARN. PERHAPS THE LAST REMAINING EXAMPLE OF CCC BUILT "RUSTIC STYLE" GUARD RAIL IN PARK. VIEW NE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  17. 24. WEST CONFEDERATE AVENUE, DOUBLE CULVERT APPEARS TO BE "BOX", ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. WEST CONFEDERATE AVENUE, DOUBLE CULVERT APPEARS TO BE "BOX", BUT IS PIPE WITH SQUARE HEAD WALL OPENING. NOTE ARCHED TOP STYLE USED BY CCC. VIEW SE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  18. Contextual view of Fyffe Avenue. Police station (building no. 17) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue. Police station (building no. 17) is shown in foreground. Camera facing northwest. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  19. 5. HISTORIC VIEW LOOKING FROM PENNSYLVANIA AVENUE BRIDGE SOUTH TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. HISTORIC VIEW LOOKING FROM PENNSYLVANIA AVENUE BRIDGE SOUTH TO OLD (1907 STEEL-GIRDER) K STREET BRIDGE. MLK LIBRARY. - K Street Bridge, Spanning Rock Creek & Potomac Parkway, Washington, District of Columbia, DC

  20. View of steel warehouses at Gilmore Avenue (building 710 second ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of steel warehouses at Gilmore Avenue (building 710 second in on left); camera facing east. - Naval Supply Annex Stockton, Steel Warehouse Type, Between James & Humphreys Drives south of Embarcadero, Stockton, San Joaquin County, CA

  1. 23. View of Jwing left, at Mercury Avenue, looking west ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. View of J-wing left, at Mercury Avenue, looking west - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  2. 17. View of Mercury Avenue from Apollo Drive, looking north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. View of Mercury Avenue from Apollo Drive, looking north at E-wing - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  3. B & P Tunnel east portal & North Avenue Bridge. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    B & P Tunnel east portal & North Avenue Bridge. Baltimore, Baltimore City, MD. Sec. 1201, MP 96.00. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  4. Wilkins Avenue Bridge. Violetville, Baltimore City, MD. Sec. 1201, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Wilkins Avenue Bridge. Violetville, Baltimore City, MD. Sec. 1201, MP 100.59. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  5. CHESTNUT AVENUE BRIDGE. BOWIE, PRINCE GEORGES CO., MD. Sec. 1201,, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CHESTNUT AVENUE BRIDGE. BOWIE, PRINCE GEORGES CO., MD. Sec. 1201,, MP 120.48. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  6. North Avenue Bridge. Baltimore, Baltimore City, MD. Sec. 1201, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    North Avenue Bridge. Baltimore, Baltimore City, MD. Sec. 1201, MP 96.00. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  7. 68. EAST CONFEDERATE AVENUE, BRIDGE (SECOND), ELEVATION. NOTE EARTH FILL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    68. EAST CONFEDERATE AVENUE, BRIDGE (SECOND), ELEVATION. NOTE EARTH FILL TYPE WITH NO GUARD WALL OR RAIL. (REBUILT BY CCC). VIEW E. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  8. NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), SALT LAKE CITY, UT. VIEW LOOKING SOUTH AT CEMETERY'S NORTH GATE (WPA PROJECT, 1938-1941). - Salt Lake City Cemetery, 200 N Street, Salt Lake City, Salt Lake County, UT

  9. 5. VIEW OF NORTH PARK AVENUE TRAILHEAD PARKING AREA FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW OF NORTH PARK AVENUE TRAILHEAD PARKING AREA FACING SOUTHEAST. - Arches National Park Main Entrance Road, Beginning at U.S. Highway 191, approximately 6 miles north of Moab, Moab, Grand County, UT

  10. 20. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, ARCH DETAIL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, ARCH DETAIL SHOWING BRICK ARCH FOR MAIN SPAN AND STONE VOUSSOIRS. VIEW W. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  11. Looking east along Porter Avenue, management engineering in foreground; supply ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking east along Porter Avenue, management engineering in foreground; supply department storehouse (building no. 5) (Haer no. PA-387-1) to left. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  12. GENERAL VIEW, MAIN ENTRANCE GATES, LOOKING SOUTH ACROSS WOODLANDS AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW, MAIN ENTRANCE GATES, LOOKING SOUTH ACROSS WOODLANDS AVENUE. IN 1933, A CITY OF PHILADELPHIA LAND CONDEMNATION REQUIRED THE DEMOLITION OF AN EXISTING GATEWAY COMPLETED IN 1857 ON PLANS BY JOHN MCARTHUR, JR. PAUL CRET DESIGNED THE NEW GATES IN 1936. THEY WERE COMPLETED THE FOLLOWING YEAR AND MOVED TO THEIR PRESENT LOCATION IN 1948 AFTER ANOTHER CITY LAND CONDEMNATION. - Woodlands Cemetery, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

  13. 22. View looking north on Central Avenue from Washington Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. View looking north on Central Avenue from Washington Street. The Stroud Building (with awnings on the second story) is located on the east (right) side of the street near the center of the block. The original Adams Hotel is seen at the right rear of the photograph Circa 1901-1910. Credit ADLAPR. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

  14. 32. AERIAL VIEW OF ARROYO SECO PARKWAY AT AVENUE 60. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. AERIAL VIEW OF ARROYO SECO PARKWAY AT AVENUE 60. AT&SF RAILROAD BRIDGE AT BACK. NOTE AVENUE 60 ACCESS ROAD AND BRIDGE OVER ARROYO SECO. DEBS PARK HILL AT CENTER IS LOCATION OF CAMERA POSITION FOR PHOTOGRAPHS CA-265-13, CA265-14, AND CA-265-V-4. LOOKING NE. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  15. VIEW OF PIEDMONT AVENUE AT BANCROFT WAY SEEN FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT BANCROFT WAY SEEN FROM WEST SIDE OF PIEDMONT LOOKING SOUTH WITH BRICK WALL RUNNING NORTH TO SOUTH IN FRONT OF 2302 PIEDMONT (F. WOODWARD HOUSE BY EDWARD B. SEELY, 1909). Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  16. GENERAL VIEW, WEST SIDE OF UBER STREET FROM SUSQUEHANNA AVENUE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW, WEST SIDE OF UBER STREET FROM SUSQUEHANNA AVENUE, LOOKING SOUTHWEST. THE PHILADELPHIA REAL ESTATE RECORD AND BUILDERS’ GUIDE ANNOUNCED IN AUGUST 1886 THAT A “COL. FLOOD” HAD “JUST FINISHED” THIRTY-TWO NINE AND TEN-ROOM HOUSES ON UBER STREET, SIXTEEN ON EACH SIDE ARRANGED IN EIGHT PAIRS OF TWO. WILLIS G. HALE WAS THE ARCHITECT USED FOR THE PROJECT. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  17. 5 CFR 551.703 - Avenues of review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT FLSA Claims and Compliance § 551.703 Avenues of review. (a... did not specifically exclude matters under the Act from the scope of the NGP, the claimant must use that NGP as the exclusive administrative remedy for all claims under the Act. There is no right...

  18. 5 CFR 551.703 - Avenues of review.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT FLSA Claims and Compliance § 551.703 Avenues of review. (a... did not specifically exclude matters under the Act from the scope of the NGP, the claimant must use that NGP as the exclusive administrative remedy for all claims under the Act. There is no right...

  19. 5 CFR 551.703 - Avenues of review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT FLSA Claims and Compliance § 551.703 Avenues of review. (a... did not specifically exclude matters under the Act from the scope of the NGP, the claimant must use that NGP as the exclusive administrative remedy for all claims under the Act. There is no right...

  20. 5 CFR 551.703 - Avenues of review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT FLSA Claims and Compliance § 551.703 Avenues of review. (a... did not specifically exclude matters under the Act from the scope of the NGP, the claimant must use that NGP as the exclusive administrative remedy for all claims under the Act. There is no right...

  1. 5 CFR 551.703 - Avenues of review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT FLSA Claims and Compliance § 551.703 Avenues of review. (a... did not specifically exclude matters under the Act from the scope of the NGP, the claimant must use that NGP as the exclusive administrative remedy for all claims under the Act. There is no right...

  2. VIEW SOUTH FROM HAMILTON AVENUE BUILDING 25 LEFT; BUILDING 32 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTH FROM HAMILTON AVENUE BUILDING 25 LEFT; BUILDING 32 MACHINE SHOP (1890) LEFT CENTER BUILDING 31 RIGGER'S SHOP (1890) CENTER BUILDING 28 BLACKSMITH SHOP (1885) RIGHT CENTER; BUILDING 27 PATTERN SHOP (1853) RIGHT - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  3. 69. 129 HILLSIDE AVENUE, BRONX, SUBSTATION, D. C. SIDE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    69. 129 HILLSIDE AVENUE, BRONX, SUBSTATION, D. C. SIDE OF ROTARY VISIBLE-NOTE COPPER BRUSHES IN PLACE OF SLIP RINGS. THE THREE TRANSFORMER '5'S REDUCE VOLTAGE OF CURRENT PASSING TO ROTARY '5'. NOTE ROTARY CONVERTER MOUNTED IN HARDWOOD BASE INDEPENDENT OF SUBSTATION FLOOR. - Interborough Rapid Transit Subway (Original Line), New York County, NY

  4. 70. HILLSIDE AVENUE, BRONX, SUBSTATION, LOOKING SOUTH TO RAISED CONTROL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    70. HILLSIDE AVENUE, BRONX, SUBSTATION, LOOKING SOUTH TO RAISED CONTROL POARD GALLERY. VIEW DOWN ROW OF ROTARY CONVERTERS, ALTERNATING CURRENT SIDE-NOTE SLIP RINGS ON SONVERTED SHAFT JUST AT THE HUB. - Interborough Rapid Transit Subway (Original Line), New York County, NY

  5. Structures of Urban Poverty in Greg Sarris's "Grand Avenue"

    ERIC Educational Resources Information Center

    Dyck, Reginald

    2010-01-01

    Greg Sarris's 1994 "Grand Avenue" offers tough urban stories about a long-fought, still-continuing struggle for survival and self-determination. Sarris's stories present the day-to-day lives of a contemporary, fictional Pomo community living in a multiracial neighborhood not far from their traditional homeland. The stories depict poverty, high…

  6. 14. View of Park Avenue to northeast across the San ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. View of Park Avenue to northeast across the San Francisco River. From left to right can be seen AZ-191 (Clifton Mineral Hot Springs Bath House), AZ-192 (Milk Depot) and AZ-193 (Presbyterian Church). - Clifton Townsite, Confluence of Chase Creek & San Francisco River, Clifton, Greenlee County, AZ

  7. 54. STEEL COMPLEX FROM CLARK AVENUE BRIDGE, LOOKING NORTHEAST. FOUNDRY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    54. STEEL COMPLEX FROM CLARK AVENUE BRIDGE, LOOKING NORTHEAST. FOUNDRY IN FOREGROUND, INGOT MOLDS ON TRACK AT RIGHT, BASIC OXYGEN FURNACE ON TRACK AT RIGHT. - Corrigan, McKinney Steel Company, 3100 East Forty-fifth Street, Cleveland, Cuyahoga County, OH

  8. 1. Photocopy of Photograph. VIEW LOOKING DOWN SOUTHERN AVENUE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of Photograph. VIEW LOOKING DOWN SOUTHERN AVENUE IN TEMPE, ARIZONA, INTO THE BARTLETT-HEARD LAND AND CATTLE COMPANY. Photographer: Unknown, circa 1925. Source: Phoenix Public Library - San Francisco Canal, Between Fortieth & Weir & Thirty-sixth Street & Roeser Road, Phoenix, Maricopa County, AZ

  9. 15. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, MP 30.26. (See HAER No. CT-13 for further documentation on this structure). - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  10. 14. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, MP 30.26. (See HAER No. CT-13 for further documentation on this structure). - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  11. 17. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, MP 30.26. (See HAER No. CT-13 for further documentation on this structure). - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  12. 13. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, MP 30.26. (See HAER No. CT-13 for further documentation on this structure). - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  13. 16. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, MP 30.26. (See HAER No. CT-13 for further documentation on this structure). - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  14. 72. Crown Street, Chapel Street, Court Street & Grand Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. Crown Street, Chapel Street, Court Street & Grand Avenue Bridges. New Haven, New Haven Co., CT. Sec. 9108, MP 72.63/. 71/.80/.94. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  15. 12. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, MP 30.26. (See HAER No. CT-13 for further documentation on this structure). - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  16. Development Plan for Relocation to the Nichols Avenue School

    ERIC Educational Resources Information Center

    21st Century School Fund, 2004

    2004-01-01

    In this report, Thurgood Marshall Academy Public Charter High School (TMA) submits its Development Plan for the renovation and improvements to the Nichols Avenue School building and site, which will serve as the future home for their school. Working with an experienced planning, design and construction team, they have prepared a Development Plan…

  17. 17. VIEW OF RCA COMMUNICATIONS RECEIVING STATION DOWN AVENUE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. VIEW OF RCA COMMUNICATIONS RECEIVING STATION DOWN AVENUE OF MONTEREY CYPRESS. THE TREES WERE CAREFULLY CULTIVATED TO FORM A LANDSCAPED APPROACH TO THE STATION. NOTE ANTENNA FIELD AT LEFT VIEW 312 DEGREES NORTHWEST. - Marconi Radio Sites, Receiving, Point Reyes Station, Marin County, CA

  18. German Round the Corner: Die Whyte Avenue in Edmonton.

    ERIC Educational Resources Information Center

    Wicke, Mariele; Wicke, Rainer E.

    This compilation of interviews and photographs is the result of a German class project entitled Whyte Avenue. The project was carried out by fifth and sixth grade students who were attending an after-school German course in Edmonton, Alberta. The course introduced students to the German language and culture by exposing them to native German…

  19. 5. HANCOCK AVENUE NEAR HIGH WATER MARK LOOKING SOUTH TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. HANCOCK AVENUE NEAR HIGH WATER MARK LOOKING SOUTH TO PENNSYLVANIA MONUMENT. NOTE LINE OF MONUMENTS AND CONTEMPORARY ADAPTATION OF GUTTER, (PAVED WITH YELLOW CAUTION MARKINGS) NOT STONE LINED. VIEW S. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  20. 12. DOUBLEDAY AVENUE NEAR MUMMASBURG ROAD. NOTE TRUNCATED OBSERVATION TOWER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. DOUBLEDAY AVENUE NEAR MUMMASBURG ROAD. NOTE TRUNCATED OBSERVATION TOWER AND ROAD SIGN VARIATIONS (CAST IRON PLACE NAME AT LEFT / AUTO TOUR SIGN AT RIGHT). ALSO NOTE CONCRETE BOLLARDS TO CONTROL PARKING. VIEW S. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  1. 4. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION WITH SEVENTH STREET. THE PLANT HAS MOST OF THE AMENITIES OF A SMALL TOWN - WATER SUPPLY, WASTE WATER TREATMENT, POLICE FORCE, FIRE DEPARTMENT, FOOD SERVICES, HOSPITAL, COMMUNICATIONS NETWORK, STEAM GENERATION, VEHICLE MAINTENANCE, TRANSPORTATION, AND A GOVERNMENT. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  2. View of Frank S. Hackett Memorial Park, Riverdale Avenue overpass ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Frank S. Hackett Memorial Park, Riverdale Avenue overpass (behind trees) and approaches, from rooftop of River House Apartments. Fieldston villas in background, looking south. - Henry Hudson Parkway, Extending 11.2 miles from West 72nd Street to Bronx-Westchester border, New York County, NY

  3. 51. LOOKING NORTHWEST FROM THE CLARK AVENUE BRIDGE. BLAST FURNACES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    51. LOOKING NORTHWEST FROM THE CLARK AVENUE BRIDGE. BLAST FURNACES AND LOWER ORE DOCK CAN BE SEEN AT CENTER; COKE CONVEYOR IS AT LEFT; AT RIGHT, THE TERMINAL TOWER CAN BE SEEN IN THE DISTANCE. - Corrigan, McKinney Steel Company, 3100 East Forty-fifth Street, Cleveland, Cuyahoga County, OH

  4. Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval Medical Center Oakland and Dental Clinic San Francisco Branch Clinics, Building no. 417) is shown at left. Camera facing northwest. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  5. Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval Medical Center Oakland and Dental Clinic San Francisco Branch Clinics, building no. 417) is shown at the center. Camera facing northeast. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  6. What Would Madison Avenue Do? Marketing to Teens

    ERIC Educational Resources Information Center

    Goodstein, Anastasia

    2008-01-01

    Whether one works for Nike or in a library, it is tough to attract an audience. That is where smart marketing can make all the difference. Even though libraries do not have millions of dollars to spend on slick Madison Avenue ad campaigns to entice today's teens, librarians do have access to the media that kids love, and that is a great place to…

  7. Contextual view of Fyffe Avenue between Jones and Boone Drives. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue between Jones and Boone Drives. ASA office (U.S. Border Control Environmental Office Building no. 317) is shown at center. Camera facing east. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  8. View of intersection of Foothill Avenue and South TwentySixth Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of intersection of Foothill Avenue and South Twenty-Sixth Street. Note sports field at center rear. Seen from Foothill Avenue at Parking Area No. 34, looking southwest - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  9. 22. AERIAL VIEW LOOKING EAST DOWN CENTRAL AVENUE FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. AERIAL VIEW LOOKING EAST DOWN CENTRAL AVENUE FROM WEST OF THE ADMINISTRATIVE AND SUPPORT AREA OF THE PLANT. ON THE LEFT (NORTH) SIDE OF THE STREET IN THE FOREGROUND OF THE PHOTOGRAPH IS BUILDING 111, THE GENERAL ADMINISTRATION BUILDING. TO THE EAST OF BUILDING 111 IS BUILDING 112, THE CAFETERIA. FURTHER TO THE EAST IS BUILDING 331, THE VEHICLE MAINTENANCE GARAGE AND FIRE DEPARTMENT; BUILDING 333, THE PAINT SHOP; BUILDING 334, THE ELECTRICAL AND GENERAL MAINTENANCE SHOP; AND BUILDING 551, THE GENERAL WAREHOUSE. ON THE RIGHT (SOUTH) SIDE OF CENTRAL AVENUE, IN THE FOREGROUND IS BUILDING 121, FIREARMS REPAIR. BEHIND BUILDING 121 IS BUILDING 122, EMERGENCY MEDICAL SERVICES, AND BUILDING 123, HEALTH PHYSICS LABORATORY. BUILDING 441, THE PRODUCTION ... - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  10. 7. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION WITH SEVENTH STREET. THE PLANT WAS BUILT ON THE SITE WITH FOUR SEPARATE PRODUCTION AREAS, AND AN ADMINISTRATION AND SUPPORT AREA. THIS PHOTOGRAPH SHOWS THE EASTERN EDGE OF THE CORE ADMINSTRATION AND SUPPORT AREA, BUILT IN THE EARLY 1950S. IN THE LEFT FOREGROUND OF THE PHOTOGRAPH IS BUILDING 442, USED TO TEST ALL HEPA FILTERS ON SITE. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  11. 53. VIEW LOOKING SOUTHWEST FROM THE CLARK AVENUE BRIDGE. REPUBLIC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. VIEW LOOKING SOUTHWEST FROM THE CLARK AVENUE BRIDGE. REPUBLIC SPRAWLS ALONG 798 ACRES ON BOTH SIDES OF THE CUYAHOGA RIVER. IN THE DISTANCE, AT CENTER, BLAST FURNACES NOs. 5 AND 6 AND THE PLANT'S UPPER DOCK CAN BE SEEN. VERTICAL LEFT BRIDGE, IN FOREGROUND, CONNECTS BLAST FURNACES NOs. 1 AND 4 WITH THE STEEL FURNACE AND ROLLING MILL. - Corrigan, McKinney Steel Company, 3100 East Forty-fifth Street, Cleveland, Cuyahoga County, OH

  12. 6. VIEW LOOKING NORTH ON SIXTH STREET, ACROSS CENTRAL AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW LOOKING NORTH ON SIXTH STREET, ACROSS CENTRAL AVENUE. THE BUILDING ON THE RIGHT IS BUILDING 551, BUILT IN 1953 AS A WAREHOUSE AND METAL FABRICATION SHOP. THE BUILDING ON THE LEFT IS BUILDING 334, ALSO BUILT IN 1953, AS THE ELECTRICAL AND GENERAL MAINTENANCE SHOP. IN THE CENTER OF THE PHOTOGRAPH IN THE BACKGROUND IS BUILDING 374, THE AQUEOUS PROCESS WASTE TREATMENT PLANT. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  13. 80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT GUN HILL STATION. 7TH AVENUE EL EXPRESS IS VISIBLE ABOVE THE 3RD AVENUE EL WHICH JOINED ONTO THE SAME STRUCTURE AT GUN HILL ROAD. NOTE: GUN HILL ROAD IS THE NORTH TERMINUS OF THE 3RD AVENUE ELEVATED. TRAINS DID NOT CARRY PASSENGERS BEYOND THIS POINT, ALTHOUGH THE 3RD AVENUE TRACK DID EXTEND FURTHER NORTH FOR SWITCHING PURPOSES AND INTO THE YARDS. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

  14. 8. PARK AVENUE EAST OF CEDAR STREET (400 Block). THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. PARK AVENUE EAST OF CEDAR STREET (400 Block). THE MARCHION HARDWARE BUILDING WAS DESIGNED BY W.W. HISLOP, AND BUILT IN 1895. THE GROUND FLOOR WAS RENOVATED SOME TIME IN THE 1930s. IN THE CENTER IS THE IMPERIAL BLOCK (ca. 1920), AND THE FULLER DRUG COMPANY (1918-1932).THE FULLER SITE WAS OCCUPIED BY THE HIGHLAND THEATER FROM 1932 TO 1972, AND RETAINS MUCH OF THE INTERIOR DECORATION FROM THAT PERIOD - Anaconda Historic District, Park & Commercial Streets, Main Street vicinity, Anaconda, Deer Lodge County, MT

  15. Natural polyphenols based new therapeutic avenues for advanced biomedical applications.

    PubMed

    Agrawal, Megha

    2015-01-01

    Polyphenols are naturally occurring, synthetic or semisynthetic organic compounds that offer a vast array of advanced biomedical applications. The mostly researched polyphenolic compounds are resveratrol and flavanols, notably (-)-epicatechin. The ongoing research on clinically important resveratrol and flavanols has revealed their potentials as extremely efficient drug agents that can be leveraged for new therapeutic designs for combating stroke related injuries, cancer and renal failures. Here, we have highlighted recent developments in this area with an emphasis on the biomedical applications of polyphenols. Also, a perspective on the future research directions has been discussed. We believe that this review would facilitate further research and development of polyphenols as a therapeutic avenue in medical science.

  16. 2. Copy of early 20th century photograph showing Euclid Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Copy of early 20th century photograph showing Euclid Avenue facade, looking norh. Photograph owned by H.D. Koblitz. - F. B. Stearns Company, Euclid & Lakeview Avenues, Cleveland, Cuyahoga County, OH

  17. 1. MEMORIAL HALL AND COURTHOUSE/LIBRARY EAST FRONT FROM CEDAR AVENUE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. MEMORIAL HALL AND COURTHOUSE/LIBRARY EAST FRONT FROM CEDAR AVENUE, CAMERA FACING WEST. - Lancaster County Center, Memorial Hall & Courthouse/Library, 4845 Cedar Avenue, Lancaster, Los Angeles County, CA

  18. 76 FR 51029 - Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron... Mercury site in Iron Mountain, Dickenson County, Michigan with the following settling parties: The.... Comments should reference the Carpenter Avenue Mercury site, Iron Mountain, Dickenson County, Michigan...

  19. 1. General view of underside of AbbeyAvenue branch of the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. General view of underside of Abbey-Avenue branch of the Central viaduct (1886-1888), looking East. This bridge, like the rest of the viaduct, consists of a series of iron and steel spans, supported on iron towers resting on cut-stone foundations. The stairway visible in the photograph led from Scranton Avenue on the valley floor to the bridge deck. - Abbey Avenue Viaduct, Spanning Walworth Valley at Abbey Avenue, Cleveland, Cuyahoga County, OH

  20. 33. 193195 AUBURN AVENUE (Callaway BuildingGeorgia Insurance Brokerage Inc.) (Consolidated ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. 193-195 AUBURN AVENUE (Callaway Building--Georgia Insurance Brokerage Inc.) (Consolidated Mortgage Building--Three Sisters Beauty Shop; Alston & Co. Realty and Property Management) NORTH ELEVATION - 126-255 Auburn Avenue (Commercial Buildings), Auburn Avenue, Atlanta, Fulton County, GA

  1. View of South TwentySixth Street at Foothill Avenue looking at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Sixth Street at Foothill Avenue looking at Cutting Boulevard in center distance, looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  2. View of intersection of Foothill Avenue and South TwentySixth Street ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of intersection of Foothill Avenue and South Twenty-Sixth Street seen from South Twenty-Sixth Street. Note Building No. 35 on right, and Buildings No. 37, 38, 40, from left to center rear, looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  3. View of Hinkley Avenue at intersection with South TwentyEighth Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue at intersection with South Twenty-Eighth Street. Buildings No. 14, 11, 12, 13, 16, and 17 from left to right. Looking west - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  4. View of Foothill Avenue at intersection with South TwentyEighth Street ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Foothill Avenue at intersection with South Twenty-Eighth Street at right. Buildings No. 41, 38, 40, 42, and 43 from left to right. Looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  5. View of South TwentySixth Street at intersection with Hinckley Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Sixth Street at intersection with Hinckley Avenue. Buildings No. 18, 22, 40, 21, 17, and 16 seen from left to right. Looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  6. View of South TwentyEighth Street at intersection with Foothill Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Eighth Street at intersection with Foothill Avenue. Seen from Buildings No. 44, 45, 47, and 41 from left to right. Looking south - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  7. Trained immunity: a new avenue for tuberculosis vaccine development.

    PubMed

    Lerm, M; Netea, M G

    2016-04-01

    Adaptive immunity towards tuberculosis (TB) has been extensively studied for many years. In addition, in recent years the profound contribution of innate immunity to host defence against this disease has become evident. The discovery of pattern recognition receptors, which allow innate immunity to tailor its response to different infectious agents, has challenged the view that this arm of immunity is nonspecific. Evidence is now accumulating that innate immunity can remember a previous exposure to a microorganism and respond differently during a second exposure. Although the specificity and memory of innate immunity cannot compete with the highly sophisticated adaptive immune response, its contribution to host defence against infection and to vaccine-induced immunity should not be underestimated and needs to be explored. Here, we present the concept of trained immunity and discuss how this may contribute to new avenues for control of TB.

  8. Ignored avenues in alpha-synuclein associated proteopathy.

    PubMed

    Chowhan, Rimpy K; Mittal, Shruti; Dar, Tanveer A; Kamal, Mohammad A; Singh, Laishram R

    2014-01-01

    Alpha-Synuclein (αSyn) is a 14 kDa pre-synaptic protein predominantly expressed in various regions of brain comprising neocortex, hippocampus, striatum, thalamus and cerebellum. αSyn aggregates have special neuropathologic relevance for comprehending Parkinson's disease (PD) and other synucleopathies due to the presence of αSyn aggregates in brain of patients suffering from these diseases. Direct relationship between PD and various single nuclear polymorphisms of αSyn further displays an inherent significance of mutated αSyn in increasing the risk for developing PD. So far, various theories have been emerged to explain αSyn mediated neuronal cell toxicity seen in patients with PD, including interaction of αSyn aggregates with biomolecules, vesicle dystrafficking, augmented oxidative stress, mitochondrial dysfunction, and disruption of synaptic function. Despite the advances in understanding of PD pathophysiology, current available treatments are still aiming at giving symptomatic relief. Lately, PD vaccines against αSyn aggregates are also being considered. However, various other avenues for e.g. post-translational and conformational modifications of αSyn, effect of cellular small molecules such as polyamines and osmolytes on αSyn aggregation, still remain unexplored and we believe that therapeutics directed at these ignored targets will surface as a successful combinational therapy for PD. Additionally, understanding mechanisms behind the interplay between PD and other health conditions, such as Gaucher's disease, Cardiovascular disorders, Hypertension, Homocystinuria, Type-II Diabetes, and Cancer are also speculated to provide great insight for novel therapeutic interventions. In the current review, we have precisely discussed all these ignored avenues with their possible clinical implications. Link between PD and other associated diseases has also been extensively reviewed. PMID:25230221

  9. A multi-isotope approach to understanding the evolution of Cenozoic magmatism in the northeastern Basin and Range: Results from igneous rocks in the Albion-Raft River-Grouse Creek metamorphic core complex

    NASA Astrophysics Data System (ADS)

    Konstantinou, A.; Strickland, A.; Miller, E. L.

    2012-12-01

    Deep crustal rocks exposed by extensional processes in metamorphic core complexes provide a unique opportunity to address the magmatic and isotopic evolution of the crust and assess the relative crust versus mantle contributions in Cenozoic igneous rocks exposed in the complexes. The Albion-Raft River-Grouse Creek metamorphic core complex exposes mid-crustal rocks that resided at depths of ~15-20 km before the onset of Cenozoic extension. Three major Cenozoic magmatic events are represented in the complex and have been studied using multiple isotopic systems (whole rock Sr and Nd coupled with the Oxygen isotopes in zircon). These three major events are: (1) 42-31 Ma intrusion of a composite plutonic complex of calc-alkaline composition that intrudes both upper crustal rocks (~5-10 km depth) and deeper rocks. (2) A 32-25 Ma plutonic complex, with evolved calc-alkaline composition that intruded in the middle crust (~12-15 km depth), and (3) A 10-8 Ma bimodal (basalt-rhyolite) suite of volcanic rocks that contain high-T anhydrous mineral assemblages erupted across the complex. The pre-extensional crust consisted of an upper crust composed primarily of Neoproterozoic through Triassic metasedimentary rocks (schist and quartzite at its base and limestone at its top). The middle crust consists of late Archean orthogneiss with evolved composition (metamorphosed peraluminous granite) with average 87Sr/86Sr40~0.800, ɛNd40~ -43.4 and δ18Ozirc ~5.7‰. The lower crust is inferred to have been composed of Precambrian intermediate composition igneous rocks with average 87Sr/86Sr40~0.750, ɛNd40~ -37.5 and δ18Ozirc ~5.9‰, and Precambrian mafic rocks with average 87Sr/86Sr40~0.717, ɛNd40~ -25 and δ18Ozirc ~7.0‰. Existing and new data indicate that the 42-31 Ma upper crustal plutonic complex ranges in isotopic composition from 87Sr/86Sri=0.709-0.712, ɛNdi=-15 to -25 and δ18Ozirc 4.7-6.5‰. The composition of the 32-25 Ma middle crustal plutonic complex ranges from 87Sr

  10. Avenues of access to future science teachers: An interview study

    NASA Astrophysics Data System (ADS)

    Weiss, Richard

    2007-12-01

    This research study explored the experiences of individuals who chose careers in secondary science education by examining two cohorts of science education students in a teacher credential program and a group of current secondary science teachers in their first five years of teaching. Issues of how these individuals became interested in science education and the characteristics common among them were examined. This study explored the educational experiences that appeared to contribute to people becoming science teachers. This study also explored the participants' motivation and key turning point moments that appeared to contribute to their choice to pursue a career in science education. The research design used in this study was a two-year, semi-structured interview protocol. Research was conducted at one main university site and within one local unified school district. During the 2004-2005 and 2005-2006 academic years, twenty-five secondary science pre-service teacher candidates at a University of California were interviewed, and during the 2005-2006 academic year, twenty-five current practicing science teachers within a Southern California unified school district were also interviewed. Data collection consisted of interviews with the fifty participants typically between 30-45 minutes in length. The EZ-Text software program was employed to aid in the analysis of the transcribed interview data. This study found that much of the previous research on the characteristics of entrants to teaching in general was supported, but that some specific differences exist among science teachers and the general population of teachers. The majority of the participants had exposure to internships or tutoring experiences and indicated that this made them more willing to pursue science teaching as a profession. This study found that high achieving female students constituted the entire female portion of the sample and cited teaching as a friendly avenue for females in science. Teacher

  11. Serial femtosecond crystallography opens new avenues for Structural Biology.

    PubMed

    Coe, Jesse; Fromme, Petra

    2016-01-01

    Free electron lasers (FELs) provide X-ray pulses in the femtosecond time domain with up to 10(12) higher photon flux than synchrotrons and open new avenues for the determination of difficult to crystallize proteins, like large complexes and human membrane proteins. While the X-ray pulses are so strong that they destroy any solid material, the crystals diffract before they are destroyed. The most successful application of FELs for biology has been the method of serial femtosecond crystallography (SFX) where nano or microcrystals are delivered to the FEL beam in a stream of their mother liquid at room temperature, which ensures the replenishment of the sample before the next X-ray pulse arrives. New injector technology allows also for the delivery of crystal in lipidic cubic phases or agarose, which reduces the sample amounts for an SFX data set by two orders of magnitude. Time-resolved SFX also allows for analysis of the dynamics of biomolecules, the proof of principle being recently shown for light-induced reactions in photosystem II and photoactive yellow protein. An SFX data sets consist of thousands of single crystal snapshots in random orientations, which can be analyzed now "on the fly" by data analysis programs specifically developed for SFX, but de-novo phasing is still a challenge, that might be overcome by two-color experiments or phasing by shape transforms.

  12. NOVEL AVENUES OF DRUG DISCOVERY AND BIOMARKERS FOR DIABETES MELLITUS

    PubMed Central

    Maiese, Kenneth; Chong, Zhao Zhong; Shang, Yan Chen; Hou, Jinling

    2011-01-01

    Globally, developed nations spend a significant amount of their resources on healthcare initiatives that poorly translate into increased population life expectancy. As an example, the United States devotes sixteen percent of its gross domestic product to healthcare, the highest level in the world, but falls behind other nations that enjoy greater individual life expectancy. These observations point to the need for pioneering avenues of drug discovery to increase lifespan with controlled costs. In particular, innovative drug development for metabolic disorders such as diabetes mellitus (DM) becomes increasingly critical given that the number of diabetic individuals will increase exponentially over the next twenty years. Here we discuss the elucidation and targeting of novel cellular pathways that are intimately tied to oxidative stress in DM for new treatment strategies. Pathways that involve wingless, NAD+ precursors, and cytokines govern complex biological pathways that determine both cell survival and longevity during DM and its complications. Furthermore, the role of these entities as biomarkers for disease can further enhance their utility irrespective of their treatment potential. Greater understanding of the intricacies of these unique cellular mechanisms will shape future drug discovery for DM to provide focused clinical care with limited or absent long-term complications. PMID:20220043

  13. Serial femtosecond crystallography opens new avenues for Structural Biology.

    PubMed

    Coe, Jesse; Fromme, Petra

    2016-01-01

    Free electron lasers (FELs) provide X-ray pulses in the femtosecond time domain with up to 10(12) higher photon flux than synchrotrons and open new avenues for the determination of difficult to crystallize proteins, like large complexes and human membrane proteins. While the X-ray pulses are so strong that they destroy any solid material, the crystals diffract before they are destroyed. The most successful application of FELs for biology has been the method of serial femtosecond crystallography (SFX) where nano or microcrystals are delivered to the FEL beam in a stream of their mother liquid at room temperature, which ensures the replenishment of the sample before the next X-ray pulse arrives. New injector technology allows also for the delivery of crystal in lipidic cubic phases or agarose, which reduces the sample amounts for an SFX data set by two orders of magnitude. Time-resolved SFX also allows for analysis of the dynamics of biomolecules, the proof of principle being recently shown for light-induced reactions in photosystem II and photoactive yellow protein. An SFX data sets consist of thousands of single crystal snapshots in random orientations, which can be analyzed now "on the fly" by data analysis programs specifically developed for SFX, but de-novo phasing is still a challenge, that might be overcome by two-color experiments or phasing by shape transforms. PMID:26786767

  14. Distant view looking west along E. O'Neill Avenue. The side ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Distant view looking west along E. O'Neill Avenue. The side (east) and front (south) of building 257 is in the right foreground. Building 256, 255, 254, and 253 are immediately beyond building 257, with their fronts facing E. O'Neill Avenue. - Fitzsimons General Hospital, Building 257, North side of East O'Neill Avenue, between Tenth & Twelfth Streets, Aurora, Adams County, CO

  15. 53. View looking north along First Street/Dayton Avenue, across covered ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. View looking north along First Street/Dayton Avenue, across covered Dundee Canal prism, toward Botany Worsted Mills - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

  16. 3. VIEW OF SITE A FROM HOOD AVENUE, FACING NORTH/NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF SITE A FROM HOOD AVENUE, FACING NORTH/NORTHWEST. (BUILDINGS 116, 117, 120, 118, 128, AND 122 ARE VISIBLE.) - Fort McPherson, World War II Station Hospital, Structures, Bordered by Hardee & Thorne Avenues & Howe Street, Atlanta, Fulton County, GA

  17. 16. Park Avenue streetscape, looking northwest AZ191 (Clifton Mineral Hot ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Park Avenue streetscape, looking northwest AZ-191 (Clifton Mineral Hot Springs Bath House) at center, AZ-193 (Presbyterian Church) at right. - Clifton Townsite, Confluence of Chase Creek & San Francisco River, Clifton, Greenlee County, AZ

  18. 31. OVERALL VIEW OF COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. OVERALL VIEW OF COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE IN RIGHT FOREGROUND AND ICE HARBOR IN LEFT BACKGROUND. VIEW TO SOUTH. - Dubuque Commercial & Industrial Buildings, Dubuque, Dubuque County, IA

  19. 1. OVERALL VIEW OF DUBUQUE COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. OVERALL VIEW OF DUBUQUE COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE IN CENTER FOREGROUND AND CHICAGO, BURLINGTON AND QUINCY RAILROAD PASSENGER DEPOT IN RIGHT FOREGROUND. VIEW TO NORTH. - Dubuque Commercial & Industrial Buildings, Dubuque, Dubuque County, IA

  20. DC66843 VIEW OF THE INDEPENDENCE AVENUE CORRIDOR SPANNED BY THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DC-668-43 VIEW OF THE INDEPENDENCE AVENUE CORRIDOR SPANNED BY THE •DEPARTMENT OF AGRICULTURE BRIDGES, LOOKING WEST FROM TWELFTH STREET, SW - L'Enfant-McMillan Plan of Washington, DC, Washington, District of Columbia, DC

  1. 18. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, BUILT 189x. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, BUILT 189x. NOTE STRAIGHT ASHLAR COURSING AND RAISED KEYSTONES. VIEW NW. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  2. COLUMN DETAIL WITH SUBSTRUCTURE/STEEL BEAM/CONCRETE BEAM AT FIRST AVENUE ONRAMP. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    COLUMN DETAIL WITH SUBSTRUCTURE/STEEL BEAM/CONCRETE BEAM AT FIRST AVENUE ON-RAMP. TRIANGLE BUILDING AT RIGHT SIDE OF PHOTOGRAPH. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

  3. Fulton Avenue Bridge/Tunnel. Baltimore, Baltimore City, MD. Sec. 1201, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Fulton Avenue Bridge/Tunnel. Baltimore, Baltimore City, MD. Sec. 1201, MP 97.56. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  4. VIEW OF FLAT GRAVE MARKERS AL0NG SAINT MIHIEL AVENUE, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF FLAT GRAVE MARKERS AL0NG SAINT MIHIEL AVENUE, WITH UPRIGHT MARKERS IN BACKGROUND. VIEW TO NORTHWEST. - Los Angeles National Cemetery, 950 South Sepulveda Boulevard, Los Angeles, Los Angeles County, CA

  5. 3. EXTERIOR/STREET LEVEL VIEW, LOOKING WEST ALONG FIRST AVENUE NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. EXTERIOR/STREET LEVEL VIEW, LOOKING WEST ALONG FIRST AVENUE NORTH WITH (LEFT TO RIGHT) CALDWELL-MILNER, MCADORY, JOHN HAND, WOODWARD BUILDINGS AND BROWN MARX BUILDING (RIGHT). ALSO PICTURED IS THE BANK FOR SAVINGS BUILDING (TOP RIGHT) AND THE RAILROAD RESERVATION (TOP LEFT TO RIGHT). VIEW TAKEN AS CITY THAWS FROM A MARCH BLIZZARD. - Heaviest Corner on Earth (Commercial), First Avenue, North & Twentieth (20th) Street, North, Birmingham, Jefferson County, AL

  6. Multi-Uses of Compensatory Programs in Reinforcing the Curriculum of Two Inner-City Schools: English Avenue Elementary School; English Avenue Primary School; 1972-73. Research and Development Report, Volume 7, Number 8, September 1973.

    ERIC Educational Resources Information Center

    Goettee, Margaret; Watts, Larry

    There are two schools bearing the name English Avenue: English Avenue Elementary School and English Avenue Primary School. The primary school, which is within the zone boundaries of the elementary school, provided grades kindergarten through 2; the Follow Through Program operated at all three grade levels. After grade two, the pupils of the…

  7. Lawrence Livermore National Laboratory East Avenue/Emergency Response Planning Traffic Study

    SciTech Connect

    Schmiegel, T

    2002-02-15

    The Lawrence Livermore National Laboratory (LLNL) and the Sandia National Laboratory (SNL) are located at the eastern end of the City of Livermore. Recently the research facilities have been placed on heightened security alerts due to the events of September 11. To respond to the security concerns, LLNL and SNL have proposed to place East Avenue between South Vasco Road and Greenville Road under administrative control. This type of control would require security check points at both ends of this segment of East Avenue, including a truck inspection facility west of the Greenville Road intersection. In this configuration, East Avenue would be closed to general public traffic. The purpose of this traffic study is to determine the potential traffic impact of placing East Avenue under administrative control. The primary focus of the traffic study is to evaluate the proposed modifications to the geometry and operation of East Avenue between South Vasco Road and Greenville Road. The study also includes a review of a traffic study prepared for the closure of East Avenue in 1989 to determine if the assumptions and conclusions of that study remain valid.

  8. Investment Avenues

    NASA Astrophysics Data System (ADS)

    Jain, Priyanka

    2012-11-01

    Investors are a heterogeneous group, they may be large or small, rich or poor, expert or lay man and not all investors need equal degree of protection (Mayya, 1996). An investor has three objectives while investing his money, namely safety of invested money, liquidity position of invested money and return on investment. The return on investment may further be divided into capital gain and the rate of return on investment as interest or dividend. Among all investment options available, securities are considered the most challenging as well as rewarding. Securities include shares, debentures, derivatives, units of mutual funds, Government securities etc. An investor may be an individual or corporate legal entity investing funds with a view to derive maximum economic advantage from investment such as rate of return, capital appreciation, marketability, tax advantage and convenience of investment.The Capital market facilitates mobilization of savings of individuals and pools them into reservoir of capital which can be used for the economic development of a country. An efficient capital market is essential for raising capital by the corporate sector of the economy and for the protection of the interest of investors in corporate securities. There arises a need to strike a balance between raising of capital for economic development on one side and protection of investors on the other. Unless the interests of investors are protected, raising of capital, by corporates is not possible. Like, the primary objective of a senior citizenís asset allocation is the generation of regular income.

  9. Electric avenues

    SciTech Connect

    Stone, P.; Chang, A.

    1994-12-31

    Highly efficient electric drive technology developed originally for defense applications is being applied to the development of all electric shuttle buses for the San Jose International Airport. An innovative opportunity charging system using induction chargers will be incorporated to extend operation hours. The project, if successful, is expected to reduce pollution at the airport and generate jobs for displaced defense workers.

  10. Walnut Springs Interest Unit, Fairmount Avenue School. Primary Unit--Team I.

    ERIC Educational Resources Information Center

    State College Area School District, PA.

    This environmental education teaching guide was designed for primary teachers who may want to develop their own environmental education units or who may wish to integrate the units contained in the guide into their own curriculum. The units in the guide were developed by primary teachers and reflect the experiences of the Fairmont Avenue School…

  11. 166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH AVE. FROM BUILDING 44 SHOWING, FROM LEFT TO RIGHT, BUILDING 46, 48, 55, AND 50 (PART OF ENLISTED BARRACKS COMPLEX), AND BUILDINGS 17, 16, 484, 483, 374, AND 375 (IN THE WAREHOUSE COMPLEX). - Quonset Point Naval Air Station, Roger Williams Way, North Kingstown, Washington County, RI

  12. Expanding the Teaching Games for Understanding Model: New Avenues for Future Research and Practice.

    ERIC Educational Resources Information Center

    Holt, Nicholas L.; Strean, William B.; Bengoechea, Enrique Garcia

    2002-01-01

    Reviews research on the Teaching Games for Understanding (TGfU) approach in physical education, noting that many discussions of TGfU have focused on cognitive and psychomotor learning outcomes and neglected the affective domain. An extended TGfU model is presented, suggesting new avenues for future research and practice (e.g., consideration of…

  13. 19. View to the north of Riverside Avenue. AZ196(J. C. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. View to the north of Riverside Avenue. AZ-196(J. C. Gatti House) at left Part of AZ-197 (Shannon Copper Company Store) can be seen in group of buildings at right - Clifton Townsite, Confluence of Chase Creek & San Francisco River, Clifton, Greenlee County, AZ

  14. 11. Park Avenue Streetscape, looking southeast. AZ184 (Clifton Water and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Park Avenue Streetscape, looking southeast. AZ-184 (Clifton Water and Improvement Company Building), AZ-185 (Tailor Shop), AZ-186(Hampton Block), AZ-187(C. F. Pascoe Undertaking) visible at left. - Clifton Townsite, Confluence of Chase Creek & San Francisco River, Clifton, Greenlee County, AZ

  15. New Avenues for History in Mathematics Education: Mathematical Competencies and Anchoring

    ERIC Educational Resources Information Center

    Jankvist, Uffe Thomas; Kjeldsen, Tinne Hoff

    2011-01-01

    The paper addresses the apparent lack of impact of "history in mathematics education" in mathematics education research in general, and proposes new avenues for research. We identify two general scenarios of integrating history in mathematics education that each gives rise to different problems. The first scenario occurs when history is used as a…

  16. DC66822 VIEW SOUTH TOWARD VIRGINIA AVENUE AND TO WEST POTOMAC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DC-668-22 VIEW SOUTH TOWARD VIRGINIA AVENUE AND TO WEST POTOMAC PARK BEYOND FROM THE ROOF OF THE DEPARTMENT OF THE INTERIOR AT 19TH AND C STREETS, NW - L'Enfant-McMillan Plan of Washington, DC, Washington, District of Columbia, DC

  17. Improving Critical Thinking Skills Using Learning Model Logan Avenue Problem Solving (LAPS)-Heuristic

    ERIC Educational Resources Information Center

    Anggrianto, Desi; Churiyah, Madziatul; Arief, Mohammad

    2016-01-01

    This research was conducted in order to know the effect of Logan Avenue Problem Solving (LAPS)-Heuristic learning model towards critical thinking skills of students of class X Office Administration (APK) in SMK Negeri 1 Ngawi, East Java, Indonesia on material curve and equilibrium of demand and supply, subject Introduction to Economics and…

  18. 75 FR 76036 - American Axle & Manufacturing Detroit Manufacturing Complex Holbrook Avenue and Saint Aubin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... December 10, 2008 (73 FR 75137). The Department's Notice was amended on January 8, 2009 to clarify that the... (subject firm). The Department's Notice was published in the Federal Register on January 15, 2009 (74 FR... Avenue and Saint Aubin Including On-Site Leased Workers From Paint Tech International Detroit,...

  19. Participation Observation: Chinese Mothers and Children at Rhodes Avenue English Classes.

    ERIC Educational Resources Information Center

    Lenskyj, Helen

    Observations of Chinese mothers and children at Rhodes Avenue (Toronto) English classes and nursery confirm the hypothesis that a high level of parental warmth-support and control tends to become, by Canadian standards, overprotectiveness, and tends to result in a submissive, dependent, over-socialized child. Dependency upon the mother for…

  20. 78 FR 19192 - Nexiant, LLC, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... August 15, 2012 (77 FR 49699 (August 16, 2012)), has continued the Regulations in effect under the IEEPA... Bureau of Industry and Security Nexiant, LLC, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying.... Until October 18, 2022, Nexiant, LLC (``Nexiant''), with a last known address at: 2531 West...

  1. Avenues to Prestige among Adolescents in Public and Religiously Affiliated High Schools

    ERIC Educational Resources Information Center

    Suitor, J. Jill; Powers, Rebecca S.; Brown, Rachel

    2004-01-01

    We used data from 1,733 college students to explore whether adolescents' avenues to prestige differ in public and private high schools. Students attending seven large universities during the 1997-98 academic year provided information on the ways in which adolescents in their high schools had gained prestige with peers. The analyses revealed no…

  2. Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues.

    PubMed

    Depp, Colin A; Dev, Sheena; Eyler, Lisa T

    2016-03-01

    Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. Although cognitive impairment is partially independent from mood episodes, depressive symptoms may increase the risk of cognitive impairment in bipolar disorder through inflammatory processes as well as health risks such as obesity and sedentary behavior. Novel treatment avenues at the intersection of bipolar depression and cognitive impairment target inflammation directly or indirectly health behaviors such as diet, physical activity, and sleep hygiene.

  3. Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues.

    PubMed

    Depp, Colin A; Dev, Sheena; Eyler, Lisa T

    2016-03-01

    Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. Although cognitive impairment is partially independent from mood episodes, depressive symptoms may increase the risk of cognitive impairment in bipolar disorder through inflammatory processes as well as health risks such as obesity and sedentary behavior. Novel treatment avenues at the intersection of bipolar depression and cognitive impairment target inflammation directly or indirectly health behaviors such as diet, physical activity, and sleep hygiene. PMID:26876321

  4. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y. 110.84 Section 110.84 Navigation and Navigable Waters COAST GUARD... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black...

  5. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  6. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  7. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  8. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  9. The Copenhagen Accord for limiting global warming: Criteria, constraints, and available avenues

    PubMed Central

    Ramanathan, Veerabhadran; Xu, Yangyang

    2010-01-01

    At last, all the major emitters of greenhouse gases (GHGs) have agreed under the Copenhagen Accord that global average temperature increase should be kept below 2 °C. This study develops the criteria for limiting the warming below 2 °C, identifies the constraints imposed on policy makers, and explores available mitigation avenues. One important criterion is that the radiant energy added by human activities should not exceed 2.5 (range: 1.7–4) watts per square meter (Wm−2) of the Earth's surface. The blanket of man-made GHGs has already added 3 (range: 2.6–3.5) Wm−2. Even if GHG emissions peak in 2015, the radiant energy barrier will be exceeded by 100%, requiring simultaneous pursuit of three avenues: (i) reduce the rate of thickening of the blanket by stabilizing CO2 concentration below 441 ppm during this century (a massive decarbonization of the energy sector is necessary to accomplish this Herculean task), (ii) ensure that air pollution laws that reduce the masking effect of cooling aerosols be made radiant energy-neutral by reductions in black carbon and ozone, and (iii) thin the blanket by reducing emissions of short-lived GHGs. Methane and hydrofluorocarbons emerge as the prime targets. These actions, even if we are restricted to available technologies for avenues ii and iii, can reduce the probability of exceeding the 2 °C barrier before 2050 to less than 10%, and before 2100 to less than 50%. With such actions, the four decades we have until 2050 should be exploited to develop and scale-up revolutionary technologies to restrict the warming to less than 1.5 °C. PMID:20439712

  10. The Copenhagen Accord for limiting global warming: criteria, constraints, and available avenues.

    PubMed

    Ramanathan, Veerabhadran; Xu, Yangyang

    2010-05-01

    At last, all the major emitters of greenhouse gases (GHGs) have agreed under the Copenhagen Accord that global average temperature increase should be kept below 2 degrees C. This study develops the criteria for limiting the warming below 2 degrees C, identifies the constraints imposed on policy makers, and explores available mitigation avenues. One important criterion is that the radiant energy added by human activities should not exceed 2.5 (range: 1.7-4) watts per square meter (Wm(-2)) of the Earth's surface. The blanket of man-made GHGs has already added 3 (range: 2.6-3.5) Wm(-2). Even if GHG emissions peak in 2015, the radiant energy barrier will be exceeded by 100%, requiring simultaneous pursuit of three avenues: (i) reduce the rate of thickening of the blanket by stabilizing CO(2) concentration below 441 ppm during this century (a massive decarbonization of the energy sector is necessary to accomplish this Herculean task), (ii) ensure that air pollution laws that reduce the masking effect of cooling aerosols be made radiant energy-neutral by reductions in black carbon and ozone, and (iii) thin the blanket by reducing emissions of short-lived GHGs. Methane and hydrofluorocarbons emerge as the prime targets. These actions, even if we are restricted to available technologies for avenues ii and iii, can reduce the probability of exceeding the 2 degrees C barrier before 2050 to less than 10%, and before 2100 to less than 50%. With such actions, the four decades we have until 2050 should be exploited to develop and scale-up revolutionary technologies to restrict the warming to less than 1.5 degrees C.

  11. HOT CELL BUILDING, TRA632. CONTEXTUAL VIEW ALONG WALLEYE AVENUE, CAMERA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HOT CELL BUILDING, TRA-632. CONTEXTUAL VIEW ALONG WALLEYE AVENUE, CAMERA FACING EASTERLY. HOT CELL BUILDING IS AT CENTER LEFT OF VIEW; THE LOW-BAY PROJECTION WITH LADDER IS THE TEST TRAIN ASSEMBLY FACILITY, ADDED IN 1968. MTR BUILDING IS IN LEFT OF VIEW. HIGH-BAY BUILDING AT RIGHT IS THE ENGINEERING TEST REACTOR BUILDING, TRA-642. INL NEGATIVE NO. HD46-32-1. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  12. Avenues to prestige among adolescents in public and religiously affiliated high schools.

    PubMed

    Suitor, J Jill; Powers, Rebecca S; Brown, Rachel

    2004-01-01

    We used data from 1,733 college students to explore whether adolescents' avenues to prestige differ in public and private high schools. Students attending seven large universities during the 1997--98 academic year provided information on the ways in which adolescents in their high schools had gained prestige with peers. The analyses revealed no differences by high school type for girls, with the exception of greater emphasis on clothes in public schools as compared with private schools. For boys, the differences were more pronounced. Boys who attended private schools were less likely than those who attended public schools to accrue prestige through clothes and car ownership and more likely to gain prestige through general sociability and having a good reputation. However, boys who attended private schools were more likely to gain prestige through being the class clown. Taken together, the findings show few differences between avenues to prestige for girls in private and public high schools, and differences for boys that are not uniformly in the direction that parents and private school advocates would predict or desire.

  13. Immunomodulation - a disease-modifying avenue for treatment of Huntington's disease?

    PubMed

    Björkqvist, Maria

    2016-06-01

    This Editorial highlights a study published in the current issue of Journal of Neurochemistry by Dobson et al. (), investigating whether the immunomodulatory agent, laquinimod exerts an immunomodulatory effect on isolated Huntington's disease monocytes. In Huntington's disease (HD) a central immune activation is mirrored in the periphery by a low-grade immune response and monocytes isolated from HD gene carriers have been shown pathologically hyperreactive in response to stimulation. This hyperreactive immune system has become recognized as an important feature of HD pathogenesis and the employment of a strategy to affect this hyperreactivity could be a potential disease-modifying avenue in HD. Read the highlighted article 'Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells' on page 782. PMID:27059524

  14. Avenues into Food Planning: A Review of Scholarly Food System Research

    PubMed Central

    Brinkley, Catherine

    2014-01-01

    This review summarizes several avenues of planning inquiry into food systems research, revealing gaps in the literature, allied fields of study and mismatches between scholarly disciplines and the food system life cycle. Planners and scholars in associated fields have identified and defined problems in the food system as ‘wicked’ problems, complex environmental issues that require systemic solutions at the community scale. While food justice scholars have contextualized problem areas, planning scholars have made a broad case for planning involvement in solving these wicked problems while ensuring that the functional and beneficial parts of the food system continue to thrive. This review maps the entry points of scholarly interest in food systems and planning’s contributions to its study, charting a research agenda for the future. PMID:24932131

  15. Results of the radiological survey at 1047 Central Avenue, Albany, New York (AL209)

    SciTech Connect

    Hall, S.C.; Marley, J.L.

    1987-11-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1047 Central Avenue in Albany, New York was the subject of a radiological investigation initiated August 26, 1986. The commercial property consists of a two-story frame building located on an irregular lot. An asphalt drive connects the property to the street. A diagram of the property showing the approximate boundaries and the 6-m grid network established for measurements outside the building is shown. The lot included in the radiological survey was /approximately/18 m wide by 60 m deep. Front and rear views of the property are shown. 13 refs., 5 figs., 5 tabs.

  16. Results of the radiological survey at 7 Maplewood Avenue, Colonie, New York

    SciTech Connect

    Marley, J.L.

    1987-12-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 7 Maplewood Avenue in Colonie, New York, was the subject of a radiological investigation initiated May 8, 1986. The residential property consisted of a house and a garage located on a rectangular lot. An asphalt-paved driveway connected the garage with the street. A diagram of the property showing the approximate boundaries and the 4-m grid network established for measurements outside the house is shown. The lot included in the radiological survey was /approximately/12 m wide by 35.5 m deep. Front and rear views of the property are shown. 13 refs., 5 figs., 5 tabs.

  17. Arc View/Avenue: Coding styles and utility scripts for efficient development

    SciTech Connect

    Ganter, J.

    1996-05-07

    Effectiveness and efficiency of software development can be greatly increased by writing modularized code using informal (styles) and formal (standards) work approaches. Software development is about connecting pieces into a coherent whole. Thus consistent work approaches provide a structure that allows individuals and teams to minimize the time and thought put into making these connections. These investments in structure return even more benefits in the maintenance phase when old code has to be examined by new programmers, or after time has passed. We present some examples of coding style for Avenue: a simplified form of Hungarian notation (notationHungarian, stringCustomerName, etc.), script naming prefixes and suffixes, and options in script headers. We demonstrate several modular, object-like utility scripts that can be used alone or combined into other utilities. These include developer tools such as a System.Echo substitute for Windows, a Window inspector, and a script for detecting and dealing with multiple display resolutions.

  18. Results of the radiological survey at 1052 Central Avenue, Albany, New York (AL208)

    SciTech Connect

    Hall, S.C.; Marley, J.L.

    1987-11-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1052 Central Avenue in Albany, New York, was the subject of a radiological investigation initiated August 26, 1986. The residential property consists of a two-story block and frame house with a separate garage located on a rectangular lot. An asphalt driveway connects the garage to the street. A diagram of the property showing the approximate boundaries and a 6-m grid network established for measurements outside the house is shown. The lot included in the radiological survey was /approximately/17.5 m wide by 43.5 m deep. Front and side views of the property are shown. 13 refs., 5 figs., 5 tabs.

  19. Avenues into Food Planning: A Review of Scholarly Food System Research.

    PubMed

    Brinkley, Catherine

    2013-04-01

    This review summarizes several avenues of planning inquiry into food systems research, revealing gaps in the literature, allied fields of study and mismatches between scholarly disciplines and the food system life cycle. Planners and scholars in associated fields have identified and defined problems in the food system as 'wicked' problems, complex environmental issues that require systemic solutions at the community scale. While food justice scholars have contextualized problem areas, planning scholars have made a broad case for planning involvement in solving these wicked problems while ensuring that the functional and beneficial parts of the food system continue to thrive. This review maps the entry points of scholarly interest in food systems and planning's contributions to its study, charting a research agenda for the future.

  20. Results of the radiological survey at Grant Avenue Memorial Park (MJ028), Maywood, New Jersey

    SciTech Connect

    Foley, R.D.; Crutcher, J.W.; Carrier, R.F.; Floyd, L.M.

    1989-02-01

    The property discussed in this report and properties in its vicinity contaminated with residues from the former Maywood Chemical Works (MCW) were included as a decontamination research and development project under the DOE Formerly Utilized Sites Remedial Action Program. As part of this project, DOE is conducting radiological surveys in the vicinity of the site to identify properties contaminated with residues derived from the MCW. The principal radionuclide of concern is thorium-232. The radiological survey discussed in this report is part of that effort and was conducted, at the request of DOE, by members of the Measurement Applications and Development Group of Oak Ridge National Laboratory. A radiological survey of the property at Grant Avenue Memorial Park, Maywood, New Jersey, was conducted during 1987.

  1. Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

    PubMed Central

    Jariwala, Nidhi

    2016-01-01

    Hepatocellular carcinoma (HCC) accounts for the second largest number of cancer related deaths globally with limited management options for the advanced disease. Although substantial research has identified molecular targets, with strong validation in pre-clinical in vivo studies, translation of therapeutics to clinics has shown modest success. In a recent manuscript in Hepatology, Zhou and Yang et al. unravel a novel p53 associated long non-coding RNA (PRAL) as a potential prognostic marker and molecular target in HCC. Their work provides a promising approach at capitalizing the tumor suppressive role of p53 protein in fighting HCC. More importantly, it emphasizes the evolving significance of long non-coding RNAs (lncRNA) in molecular medicine. Current research trends focus on identifying and understanding roles of lncRNA in regulation of gene expression relevant to multiple disease pathophysiologies thereby presenting a new avenue of research in molecular and translational medicine. PMID:27569205

  2. Results of the radiological survey at 136 West Central Avenue (MJ030), Maywood, New Jersey

    SciTech Connect

    Foley, R.D.; Crutcher, J.W.; Carrier, R.F.; Floyd, L.M.

    1989-02-01

    As a result of the Energy and Water Appropriations Act of Fiscal Year 1984, the property discussed in this report and properties in its vicinity contaminated with residues from the former Maywood Chemical Works (MCW) were included as a decontamination research and development project under the DOE Formerly Utilized Sites Remedial Action Program. As part of this project, DOE is conducting radiological surveys in the vicinity of the site to identify properties contaminated with residues derived from the MCW. The principal radionuclide of concern is thorium-232. The radiological survey discussed in this report is part of that effort and was conducted, at the request of DOE by members of the Measurement Applications and Development Group of Oak Ridge National Laboratory. A radiological survey of the private, residential property at 136 West Central Avenue, Maywood, New Jersey, was conducted during 1987. The survey and sampling of the ground surface and subsurface were carried out on April 29, 1987.

  3. From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system.

    PubMed

    Ueno, Norikiyo; Lodoen, Melissa B

    2015-08-01

    Infection of the central nervous system (CNS) is a significant cause of morbidity and mortality, and treatments available to combat the highly debilitating symptoms of CNS infection are limited. The mechanisms by which pathogens in the circulation overcome host immunity and breach the blood-brain barrier are active areas of investigation. In this review, we discuss recent work that has significantly advanced our understanding of the avenues of pathogen dissemination to the CNS for four eukaryotic pathogens of global health importance: Toxoplasma gondii, Plasmodium falciparum, Trypanosoma brucei, and Cryptococcus neoformans. These studies highlight the remarkable diversity of pathogen strategies for trafficking to the brain and will ultimately contribute to an improved ability to combat life-threatening CNS disease. PMID:26048316

  4. Structure and seismic hazard of the Ventura Avenue anticline and Ventura fault, California

    NASA Astrophysics Data System (ADS)

    Hubbard, J.; Shaw, J. H.; Dolan, J. F.; Pratt, T. L.; McAuliffe, L. J.

    2011-12-01

    The Ventura Avenue anticline, in the western Transverse Ranges, is one of the fastest uplifting structures in southern California, rising at a rate of ~5 mm/yr (Rockwell et al., 1988). However, there is disagreement about whether this structure poses a seismic hazard, due to uncertainty about the nature of the Ventura fault, which lies along the southern margin of the fold. Two models have been proposed: either the Ventura fault extends to seismogenic depths beneath the anticline (e.g., Sarna-Wojcicki et al., 1976), or it is a shallow, bending-moment fault that does not pose a significant seismic hazard (e.g., Yeats, 1982a,b; Huftile and Yeats, 1995). Seismic data across the tip of the Ventura fault suggest that it deforms late Pleistocene and younger strata, implying that the fault system is active. Given that the fault trace extends directly through the city of Ventura, distinguishing between these two interpretations has considerable importance in regional seismic hazard assessments. We use well data, industry seismic reflection profiles, and two seismic profiles acquired by our group in August 2010, to construct a more complete 3D model of the system. Based on dipmeter logs and stratigraphic cutoffs imaged in seismic reflection profiles, we show that the north-dipping Ventura fault extends to seismogenic depth beneath the anticline. Fault offset increases with depth, implying that the Ventura fault has propagated upwards over time. Thus, we interpret the Ventura Avenue anticline to be a fault-propagation fold underlain by an active thrust ramp. A decrease in the uplift rate of the anticline at 30 ka, as measured from uplifted terraces (Rockwell et al., 1988), is consistent with a breakthrough of the Ventura fault at that time, although the fault is still blind as it is buried by a sedimentary cover. In order to assess the hazard of the fault, we examine its regional extent. The Ventura fold trend continues offshore and coincides with a set of oil fields. A 3D

  5. Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

    PubMed Central

    Tobe, Ryuta; Carlson, Bradley A.; Tsuji, Petra A.; Lee, Byeong Jae; Gladyshev, Vadim N.; Hatfield, Dolph L.

    2015-01-01

    A common characteristic of many cancer cells is that they suffer from oxidative stress. They, therefore, require effective redox regulatory systems to combat the higher levels of reactive oxygen species that accompany accelerated growth compared to the normal cells of origin. An elevated dependence on these systems in cancers suggests that targeting these systems may provide an avenue for retarding the malignancy process. Herein, we examined the redox regulatory systems in human liver and lung cancers by comparing human lung adenocarcinoma and liver carcinoma to their respective surrounding normal tissues. Significant differences were found in the two major redox systems, the thioredoxin and glutathione systems. Thioredoxin reductase 1 levels were elevated in both malignancies, but thioredoxin was highly upregulated in lung tumor and only slightly upregulated in liver tumor, while peroxiredoxin 1 was highly elevated in lung tumor, but downregulated in liver tumor. There were also major differences within the glutathione system between the malignancies and their normal tissues. The data suggest a greater dependence of liver on either the thioredoxin or glutathione system to drive the malignancy, while lung cancer appeared to depend primarily on the thioredoxin system. PMID:26569310

  6. Diagnosis of Endometrial-Factor Infertility: Current Approaches and New Avenues for Research

    PubMed Central

    Katzorke, N.; Vilella, F.; Ruiz, M.; Krüssel, J.-S.; Simón, C.

    2016-01-01

    Over the last decade, research to improve success rates in reproductive medicine has focused predominantly on the understanding and optimization of embryo quality. However, the emergence of personalized medicine in ovulation induction and embryology has shifted the focus to assessing the individual status of the endometrium. The endometrium is considered receptive during an individually defined period, the window of implantation (WOI), when the mother permits a blastocyst to attach and implant. This individual receptivity status can now be objectively diagnosed using the endometrial receptivity array (ERA) developed in 2011. The ERA, together with a computational algorithm, detects the unique transcriptomic signature of endometrial receptivity by analyzing 238 differentially expressed genes and reliably predicting the WOI. We and others have illustrated the utility of this personalized diagnostic approach to discriminate between individual physiological variation in endometrial receptivity and unknown endometrial pathology, deemed as causal in recurrent implantation failure (RIF). An international randomized controlled trial (“The ERA as a diagnostic guide for personalized embryo transfer.” ClinicalTrials.gov Identifier: NCT01954758) is underway to determine the clinical value of this endometrial diagnostic intervention in the work-up for reproductive care. In this review, we analyse the current clinical practice in the diagnosis of the endometrial factor together with new avenues of research. PMID:27365540

  7. Treatability of Ninth Avenue Superfund Site ground-water. Final report

    SciTech Connect

    Zappi, M.E.; Teeter, C.; Fleming, E.; Francingues, N.R.

    1991-03-01

    The Ninth Avenue Superfund Site is located in Gary, IN, and has been listed on the US Environmental Protection Agency's National Priorities List since 1973. The site is a 17-acre (68,800-sq m) inactive chemical disposal area within a relatively undeveloped, low-lying area. Past disposal activities resulted in the contamination of the underlying groundwater, predominantly with ketones, benzenes, phenols, and chlorinated aliphatic compounds. Four technologies were evaluated on the bench scale for their ability to remove organic contaminants from a composite of groundwater samples collected from six site observation wells. These technologies were activated sludge (aerobic biotreatment), activated sludge with powdered activated carbon (PAC) addition, air stripping, and activated carbon. The results indicate that activated carbon does not have a high sorptive capacity for the site contaminants. Air stripping did not exhibit a high potential for efficiently removing the contaminants from the composite sample. However, activated sludge indicated potential for removing the site contaminants. The addition of PAC improved contaminant removal. Increased removals of chemical oxygen demand and total organic carbon from the composite sample with increased PAC dose were observed. Activated sludge and PAC/activated carbon were capable of removing all priority pollutants to concentrations at or below detection limits.

  8. Chemical Exfoliation of Layered Superconductors: An Avenue to Synthesize Boron-rich Quasi Two Dimensional Nanostructures

    NASA Astrophysics Data System (ADS)

    Das, Saroj Kumar; Liza James, Asha; Jasuja, Kabeer

    2015-03-01

    Zero-dimensional and one-dimensional boron based nanostructures have presented excellent avenues in the past for utilizing the fascinating science of boron at the atomic level. The research on synthesizing two-dimensional (2-D) boron-based nanostructures is currently in its incipient stages. In this talk, we demonstrate two chemical approaches that yield quasi 2-D boron-rich nanostructures by enabling an exfoliation of a layered boron-based superconductor. While one approach employs the simple tool of ultrasonication in an aqueous phase, the other approach utilizes a chelation mediated strategy based on coordination of metal ions and organic ligands. Both these synthetic routes are shown to result in a processable colloidal dispersion of nanosheets. This talk will present details of the two exfoliation approaches and a comprehensive study of the morphological, chemical and optical properties of the dispersed nanosheets. We will demonstrate that the exfoliated nanosheets undergo an in-situ chemical modification with ionizable functional groups derived from solvent that enable electrostatic stabilization. We will further shown that this functionalization modifies the band structure of the nanosheets which gives rise to photoluminescence and result in physico-chemical properties distinct from the parent superconductor. This ability to synthesize quasi 2-D boron rich nanostructures significantly adds to the current state of literature on born-based quasi-planar nanostructures.

  9. New avenues for treating emotional memory disorders: towards a reconsolidation intervention for posttraumatic stress disorder

    PubMed Central

    Kindt, Merel; van Emmerik, Arnold

    2016-01-01

    The discovery that fear memories may change upon retrieval, a process referred to as memory reconsolidation, opened avenues to develop a revolutionary new treatment for emotional memory disorders. Reconsolidation is a two-phase process in which retrieval of a memory initiates a transient period of memory destabilization, followed by a protein synthesis-dependent restabilization phase. This reconsolidation window offers unique opportunities for amnesic agents to interfere with the process of memory restabilization, thereby weakening or even erasing the emotional expression from specific fear memories. Here we present four uncontrolled case descriptions of patients with symptoms of posttraumatic stress disorder (PTSD) who received a reconsolidation intervention. The intervention basically involves a brief reactivation of the trauma memory aimed to trigger memory destabilization, followed by the intake of one pill of 40 mg propranolol HCl (i.e. a noradrenergic beta-blocker) that should disrupt the process of memory restabilization. We present three cases who showed a steep decline of fear symptoms after only one or two intervention sessions. To illustrate that the translation from basic science to clinical practice is not self-evident, we also present a description of a noneffective intervention in a relatively complex case. Even though the reconsolidation intervention is very promising, the success of the treatment depends on whether the memory reactivation actually triggers memory reconsolidation. Obviously the uncontrolled observations described here warrant further study in placebo-controlled designs. PMID:27536348

  10. Paradoxical thinking as a new avenue of intervention to promote peace

    PubMed Central

    Hameiri, Boaz; Porat, Roni; Bar-Tal, Daniel; Bieler, Atara; Halperin, Eran

    2014-01-01

    In societies involved in an intractable conflict, there are strong socio-psychological barriers that contribute to the continuation and intractability of the conflict. Based on a unique field study conducted in the context of the Israeli–Palestinian conflict, we offer a new avenue to overcome these barriers by exposing participants to a long-term paradoxical intervention campaign expressing extreme ideas that are congruent with the shared ethos of conflict. Results show that the intervention, although counterintuitive, led participants to express more conciliatory attitudes regarding the conflict, particularly among participants with center and right political orientation. Most importantly, the intervention even influenced participants' actual voting patterns in the 2013 Israeli general elections: Participants who were exposed to the paradoxical intervention, which took place in proximity to the general elections, reported that they tended to vote more for dovish parties, which advocate a peaceful resolution to the conflict. These effects were long lasting, as the participants in the intervention condition expressed more conciliatory attitudes when they were reassessed 1 y after the intervention. Based on these results, we propose a new layer to the general theory of persuasion based on the concept of paradoxical thinking. PMID:25024185

  11. Ring expansion reactions of anti-aromatic boroles: a promising synthetic avenue to unsaturated boracycles.

    PubMed

    Barnard, Jonathan H; Yruegas, Sam; Huang, Kexuan; Martin, Caleb D

    2016-08-21

    Conjugated boron heterocycles have emerged as attractive synthetic targets due to their potential in medicinal chemistry and as electronic materials. However, the development of unsaturated boracycles has been hampered by difficulties in their preparation. Recently, a new synthetic avenue to access these species has been developed that takes advantage of the high reactivity of boroles. These five-membered anti-aromatic heterocycles can react with substrates to furnish ring expansion products via the insertion of one, two, or three atoms into the boracyclic ring. The ring expansion can occur via two pathways, the first exploits the activated diene moiety of the heterocycle in Diels-Alder chemistry with the resulting bicyclic species undergoing further rearrangements. The second reaction pathway is initiated by the coordination of the Lewis basic site of a substrate to the highly Lewis acidic boron center rendering the endocyclic B-C bond of the borole nucleophilic, inducing the formation of larger boracycles via attack at the electrophilic site of the substrate. This review summarizes the current state of this chemistry and details the mechanisms leading to the products. The methodologies described herein could very well be extended to other substrates, as well as applied to other anti-aromatic heterocycles.

  12. Results of the radiological survey at 133 Maywood Avenue, Maywood, New Jersey (MJ025)

    SciTech Connect

    Foley, R.D.; Carrier, R.F.; Floyd, L.M.; Crutcher, J.W. )

    1989-10-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 133 Maywood Avenue, Maywood, New Jersey (MJ025), was conducted during 1987. The survey results demonstrate that all radionuclide concentrations and measurements conform to DOE remedial action criteria. All values are at or below typical background values found in northern New Jersey. 5 refs., 2 figs., 3 tabs.

  13. Results of the radiological survey at 266 East Spring Valley Avenue (MJ024), Hackensack, New Jersey

    SciTech Connect

    Foley, R.D.; Crutcher, J.W.; Carrier, R.F.; Floyd, L.M.

    1989-02-01

    As a result of the Energy and Water Appropriations Act of Fiscal Year 1984, the property discussed in this report and properties in its vicinity contaminated with residues from the former Maywood Chemical Works (MCW) were included as a decontamination research and development project under the DOE Formerly Utilized Sites Remedial Action Program. As part of this project, DOE is conducting radiological surveys in the vicinity of the site to identify properties contaminated with residues derived from the MCW. The principal radionuclide of concern is thorium-232. The radiological survey discussed in this report is part of that effort and was conducted, at the request of DOE, by members of the Measurement Applications and Development Group of Oak Ridge National Laboratory. A radiological survey of the private, residential property at 266 East Spring Valley Avenue, Hackensack, New Jersey, was conducted during 1987. The survey and sampling of the ground surface and subsurface were carried out on April 23, 1987. 4 refs., 2 figs., 3 tabs.

  14. Results of the radiological survey at 99 Garibaldi Avenue, Lodi, New Jersey (LJ064)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.; Crutcher, J.W.

    1989-07-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally /sup 232/Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 99 Garibaldi Avenue, Lodi, New Jersey (LJ064), was conducted during 1987. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 4 refs., 8 figs., 3 tabs.

  15. Results of the radiological survey at 108 Avenue E, Lodi, New Jersey (LJ084)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-06-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally /sup 232/Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 108 Avenue E, Lodi, New Jersey (LJ084), was conducted during 1988. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs., 2 figs., 2 tabs.

  16. Results of the radiological survey at 113 Avenue E, Lodi, New Jersey (LJ081)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-06-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally /sup 232/Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 113 Avenue E, Lodi, New Jersey (LJ081), was conducted during 1988. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs, 2 figs., 3 tabs.

  17. Results of the radiological survey at 90 C Avenue, Lodi, New Jersey (LJ079)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-06-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducted an investigative radiological survey during 1988 at 90 C Avenue, Lodi, New Jersey (LJ079), one of the properties in the vicinity of the MCW site. The survey included a gamma radiation scan of the surface and at one meter above the surface, as well as radionuclide sampling of surface and subsurface soil. The survey objective was to determine whether this site was contaminated with radioactive residues derived from MCW, principally /sup 232/Th. Results of the survey demonstrated radionuclide concentrations in excess of DOE remedial action criteria, primarily from the /sup 232/Th decay chain, with some contamination from /sup 226/Ra. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs., 3 figs., 3 tabs.

  18. Polyploid formation created unique avenues for response to selection in Gossypium (cotton).

    PubMed

    Jiang, C; Wright, R J; El-Zik, K M; Paterson, A H

    1998-04-14

    A detailed restriction fragment length polymorphism map was used to determine the chromosomal locations and subgenomic distributions of quantitative trait loci (QTLs) segregating in a cross between cultivars of allotetraploid (AADD) Gossypium hirsutum ("Upland" cotton) and Gossypium barbadense ("Sea Island," "Pima," or "Egyptian" cotton) that differ markedly in the quality and quantity of seed epidermal fibers. Most QTLs influencing fiber quality and yield are located on the "D" subgenome, derived from an ancestor that does not produce spinnable fibers. D subgenome QTLs may partly account for the fact that domestication and breeding of tetraploid cottons has resulted in fiber yield and quality levels superior to those achieved by parallel improvement of "A" genome diploid cottons. The merger of two genomes with different evolutionary histories in a common nucleus appears to offer unique avenues for phenotypic response to selection. This may partly compensate for reduction in quantitative variation associated with polyploid formation and be one basis for the prominence of polyploids among extant angiosperms. These findings impel molecular dissection of the roles of divergent subgenomes in quantitative inheritance in many other polyploids and further exploration of both "synthetic" polyploids and exotic diploid genotypes for agriculturally useful variation.

  19. Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation

    PubMed Central

    McKee, Robert A.; Wingert, Rebecca A.

    2016-01-01

    Recent research has shown that fully developed organs can be decellularized, resulting in a complex scaffold and extracellular matrix (ECM) network capable of being populated with other cells. This work has resulted in a growing field in bioengineering focused on the isolation, characterization, and modification of organ derived acellular scaffolds and their potential to sustain and interact with new cell populations, a process termed reseeding. In this review, we cover contemporary advancements in the bioengineering of kidney scaffolds including novel work showing that reseeded donor scaffolds can be transplanted and can function in recipients using animal models. Several major areas of the field are taken into consideration, including the decellularization process, characterization of acellular and reseeded scaffolds, culture conditions, and cell sources. Finally, we discuss future avenues based on the advent of 3D bioprinting and recent developments in kidney organoid cultures as well as animal models of renal genesis. The ongoing mergers and collaborations between these fields hold the potential to produce functional kidneys that can be generated ex vivo and utilized for kidney transplantations in patients suffering with renal disease. PMID:27375844

  20. New avenues to heavy right-handed neutrinos with pair production at hadronic colliders

    NASA Astrophysics Data System (ADS)

    Kang, Zhaofeng; Ko, P.; Li, Jinmian

    2016-04-01

    In many models incorporating the type-I seesaw mechanism, the right-handed neutrino (N ) couples to heavy vector/scalar bosons and thereby has resonant pair production. It has barely received attention thus far; however, it may provide the best avenue to probe TeV scale N without requiring anomalously large mixing between N and the active neutrino νL . In this paper we explore the discovery prospects of (mainly heavy) N pair production at the 14 TeV LHC and future 100 TeV p p collider, based on the three signatures: (1) trilepton from N (→ℓWℓ)N (→ℓWh) with Wℓ/h being the leptonically/hadronically decaying W ; (2) boosted di-Higgs boson plus ET from N (→νLh )N (→νLh ) ; (3) a single boosted Higgs boson with leptons and ET from N (→ℓWℓ)N (→νLh ) . At the 100 TeV collider, we also consider the situation when the Higgs boson is overboosted, thus losing its jet substructure. Interpreting our tentative results in the benchmark model, the local B -L model, we find that the (multi-) TeV scale N can be probed at the (100) 14 TeV colliders.

  1. ATP synthesis revisited: new avenues for the management of mitochondrial diseases.

    PubMed

    Bagkos, Georgios; Koufopoulos, Kostas; Piperi, Christina

    2014-01-01

    Mitochondrial dysfunction has been implicated in the development of a wide spectrum of major human diseases, including diabetes mellitus, heart disorders, neurodegeneration and cancer. Several therapeutic approaches targeting mitochondrial function have been applied in most cases without however the desired outcome. The limited effectiveness of these therapeutic schemes is due to the fact that several important aspects of mitochondrial function have not been elucidated as yet, including the detailed mechanism of ATP production. Although it is known that electron transport chain (ETC) is the central machinery responsible for mitochondrial oxidative ATP production, major important functions attributed to ETC are still unresolved while other activities which are in fact carried out by the ETC have been overlooked. This review revisits ATP synthesis providing a detailed account of the experimentally-verified ETC functions focused on the ability of ETC to act as an electro-electric converter, able to accept different electrons from any given energy source (light, food or metals) in order to produce the correct voltage and store it in the form of electrostatic potentials (mitochondrial membrane potential). This stored electric energy, in the order of 3x10(7) V/m, can then be used by F1F0 ATP synthase for ATP production. The present review provides supportive evidence that this ETC function suffices to fully explain the missing parts of ATP production, thus redirecting the current therapeutic schemes for the management of mitochondrial diseases to a more complete and effective avenue. PMID:24372303

  2. 75 FR 11914 - Chrysler, LLC, Mack Avenue Engine Plants 1 & 2, Power Train Division, Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Division, Detroit, Michigan. The notice was published in the Federal Register on December 18, 2008 (73 FR..., Including On-Site Leased Workers From Caravan Knight Facilities Management LLC; Detroit, MI; Amended... Management LLC were employed on-site at the Detroit, Michigan location of Chrysler, LLC, Mack Avenue...

  3. 78 FR 19195 - RH International, LLC, 2531 West Maryland Avenue, Tampa, FL 33629, Respondent, Mohammad Reza (a/k...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ..., the most recent being that of August 15, 2012 (77 FR 49699, August 16, 2012), has continued the... Bureau of Industry and Security RH International, LLC, 2531 West Maryland Avenue, Tampa, FL 33629...; Order Denying Export Privileges A. Denial of Export Privileges of RH International, LLC On October...

  4. 78 FR 19194 - P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... being that of August 15, 2012 (77 FR 49699 (August 16, 2012)), has continued the Regulations in effect... Bureau of Industry and Security P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying... Division, P&P Computers (``P&P'') was convicted of violating the International Emergency Economic...

  5. Viral ecology of organic and inorganic particles in aquatic systems: avenues for further research

    PubMed Central

    Weinbauer, M.G.; Bettarel, Y.; Cattaneo, R.; Luef, B.; Maier, C.; Motegi, C.; Peduzzi, P.; Mari, X.

    2016-01-01

    Viral abundance and processes in the water column and sediments are well studied for some systems; however, we know relatively little about virus–host interactions on particles and how particles influence these interactions. Here we review virus–prokaryote interactions on inorganic and organic particles in the water column. Profiting from recent methodological progress, we show that confocal laser scanning microscopy in combination with lectin and nucleic acid staining is one of the most powerful methods to visualize the distribution of viruses and their hosts on particles such as organic aggregates. Viral abundance on suspended matter ranges from 105 to 1011 ml−1. The main factors controlling viral abundance are the quality, size and age of aggregates and the exposure time of viruses to aggregates. Other factors such as water residence time likely act indirectly. Overall, aggregates appear to play a role of viral scavengers or reservoirs rather than viral factories. Adsorption of viruses to organic aggregates or inorganic particles can stimulate growth of the free-living prokaryotic community, e.g. by reducing viral lysis. Such mechanisms can affect microbial diversity, food web structure and biogeochemical cycles. Viral lysis of bacterio- and phytoplankton influences the formation and fate of aggregates and can, for example, result in a higher stability of algal flocs. Thus, viruses also influence carbon export; however, it is still not clear whether they short-circuit or prime the biological pump. Throughout this review, emphasis has been placed on defining general problems and knowledge gaps in virus–particle interactions and on providing avenues for further research, particularly those linked to global change. PMID:27478304

  6. Results of the radiological survey at 110 E Hunter Avenue, Maywood, New Jersey (MJ022)

    SciTech Connect

    Foley, R.D.; Carrier, R.F.; Floyd, L.M.; Crutcher, J.W. )

    1989-09-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 110 E. Hunter Avenue, Maywood, New Jersey (MJ022), was conducted during 1987. Following the removal of a small chunk of material showing elevated gamma exposure rates, all radionuclide concentrations and measurements conformed to DOE remedial action criteria. The slightly elevated radionuclide concentrations found in other soil samples were the result of naturally enhances radioactivity characteristic of some environmental materials such as coal ash and were unrelated to operations at the MCW site. The survey data demonstrate that the property requires no further action on the part of DOE. 4 refs., 2 figs., 3 tabs.

  7. Cathodoluminescence (CL) Petrography of UHP-metamorphic Rocks: New Avenues for Petrological Applications

    NASA Astrophysics Data System (ADS)

    Schertl, H.; Neuser, R.

    2007-12-01

    Since the first application of CL microscopy on rock samples (Sippel, 1965; Marfunin, 1979), this technique has become a standard tool in mineralogy. First CL-studies, however, have mainly focused on sedimentary rocks and on zircon-zonations connected with ion probe dating. Here, we would like demonstrate the great advantages of a hot cathode CL microscope applied to UHP metamorphic rocks, in particular in conjunction with electronmicroprobe (EMP)-studies. The compilation of data presented include samples from Dora Maira/Italy, Kokchetav/Kazakhstan, Sulu/China, Western Gneiss region/Norway and Pohorje/Slovenia. Colored images of important but otherwise invisible growth features and internal structures of minerals, like small-scale growth zoning, inhomogeneities, exsolution lamellae, dissolution and deformational effects etc. can be easily achieved within seconds. Examples shown are oscillatory zoning patterns of garnet and kyanite, change of morphology during growth, regular and irregular zoning patterns of garnet, jadeite, omphacite, carbonates, clinopyroxene (partly with cracking/annealing structures), exsolution textures (dolomite/Mg-calcite; K-feldspar/pyroxene), different CL-colours of SiO2-phases (coesite: bluish- green, quartz: dark red to violet, chalcedony: yellow), and special features of accessory minerals like zircon, diamond, apatite, and bearthite. Although being mainly descriptive, the conclusions drawn open new avenues for petrological applications. The knowledge of detailed structural characteristics of rock-forming minerals has an invaluable impact on the more precise and detailed derivation of PT-paths and thus on the evolution of geodynamic processes with any metamorphic rocks involved. Thus we propose the CL-technique to be used more intensively for routine investigations of thin sections as a pathfinder prior to chemical characterization by EMP.

  8. Avenues and barriers to access of services for immigrant elders: state and local policies for OAA units on aging.

    PubMed

    Okafor, Maria C

    2009-07-01

    The diversification and aging of the US population has been at the root of many political and policy debates in recent years. Of particular interest has been the place of immigrants in an aging society, and what rights these immigrants are entitled to. The objective of this article is to describe the current avenues and barriers to access of services for immigrant elders and examine potential solutions for reform. The article begins with a historical overview of the policy issue, followed by the current status of the issue in the United States and suggestions for reform.

  9. Results of the independent radiological verification survey at 108 Avenue E, Lodi, New Jersey (LJ084V)

    SciTech Connect

    Rodriguez, R.E.; Johnson, C.A.

    1996-09-01

    Thorium ores were processed by the Maywood Chemical Works until the property was sold to Stepan Chemical Company in 1959. Wastes were stored at what is now called the Maywood Interim Storage Site (MISS), owned by the US Department of Energy (DOE). Because of the migration of residuals off site into the surrounding areas, the Stepan property and several vicinity properties were designated for remedial action under the 1984 Energy and Water Development Appropriations Act. The DOE conducted radiological surveys of these sites to evaluate current radiological conditions as part of the Formerly Utilized Sites Remedial Action Program (FUSRAP). In 1988, radiological surveys of some private residential properties on Avenue E in Lodi, New Jersey were conducted by members of an ORNL radiological survey team. Results of this survey indicated radiological contamination in excess of the DOE criteria for surface contamination at this vicinity property (108 Avenue E), and it was recommended for remediation. In the fall of 1995, a verification survey of this vicinity property was conducted by ORNL, the independent verification contractor for this effort, in conjunction with decontamination operations conducted under the supervision of Bechtel National Incorporated. The verification survey included complete surface gamma scans of the grounds and the collection of soil samples for radionuclide analysis. This report describes the radiological verification survey of this residential property.

  10. The Potential of GIS as a Management Tool for Avenue Trees Population in Small Communities; a Case Study of Idi-Shin Community, Ibadan, Nigeria

    NASA Astrophysics Data System (ADS)

    Olokeogun, O. S.; Akintola, O. O.; Abodunrin, E. K.

    2016-06-01

    This study demonstrates the potentials of Geographic Information System (GIS) as a management tool for avenue trees (Street trees) populations in small communities (using Idi-Ishin community, Ibadan, Nigeria as a case study). GIS is a decision support system which integrate data or set of data from different sources, bringing them under the same referencing system in a computer system. An Ikonos Imagery (1m Spatial Resolution) of the study area was digitized to produce a digital map using ArcGIS 10.1 version. The avenue trees species ≥ 5cm diameter at breast height (DBH) was selected for enumeration. These trees were then measured and tagged. The Height, Girth and Geographic location (X &Y coordinate) of the trees were measured with Haga altimeter, Girthing tape and Hand held Global Positioning System (GPS) respectively. The species and families of the trees enumerated were also identified. Data were analysed for basal area (BA) and volume (V). A total number of 43 avenue trees were assessed in Idi-Ishin Community. Roystonea regia accounted for the majority of the avenue trees (25.58%), followed by Polyanthia longiflora (23.26%), Gliricida seprium (20.93%), Eucalyptus toreliana (13.95%), Delunix regea (6.98%). However Terminalia catapa, Terminalia radii, Azadrachita indica and Newbodia levis had the same abundance of 2.33%. It was also observed that the benefits derived from these avenue trees includes; Carbon sequestration, Beautification, Wind break and shade. A spatial relational database was created for the assessed avenue trees using ArcCatalog of ArcGIS 10.1 version. Based on the findings from the study (which serves as baseline information for the management of the avenue trees in the study area), it was therefore recommended that subsequent assessment should be carried out at 3-5 year interval in other to ensure proper and continuous monitoring and updating of the data.

  11. Influence of avenue-trees on air quality at the urban neighborhood scale. Part I: quality assurance studies and turbulent Schmidt number analysis for RANS CFD simulations.

    PubMed

    Gromke, Christof; Blocken, Bert

    2015-01-01

    Flow and dispersion of traffic pollutants in a generic urban neighborhood with avenue-trees were investigated with Computational Fluid Dynamics (CFD). In Part I of this two-part contribution, quality assessment and assurance for CFD simulations in urban and vegetation configurations were addressed,before in Part II flow and dispersion in a generic urban neighborhood with multiple layouts of avenue trees were studied. In a first step, a grid sensitivity study was performed that inferred that a cell count of 20 per building height and 12 per canyon width is sufficient for reasonable grid insensitive solutions. Next, the performance of the realizable k-ε turbulence model in simulating urban flows and of the applied vegetation model in simulating flow and turbulence in trees was validated. Finally, based on simulations of street canyons with and without avenue-trees, an appropriate turbulent Schmidt number or modeling dispersion in the urban neighborhood was determined as Sc(t) =0.5.

  12. Avenues to Inspiration

    ERIC Educational Resources Information Center

    Campbell, Ashley

    2011-01-01

    Integrating the worlds of art and science can be a perfect tool for engaging students who wouldn't be initially interested in a science class. Even those students who love science may delve deeper into the subject when it's associated with art. One way to make this connection is to explore the life and work of great nature artists of the past and…

  13. A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

    PubMed Central

    Wu, Liangcai; Xu, Qianqian; Zhang, Haohai; Li, Ming; Zhu, Chengpei; Jiang, Minjie; Sang, Xinting; Zhao, Yi; Sun, Qiang; Zhao, Haitao

    2016-01-01

    Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition, and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding–non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage, and DNA repair. Kaplan–Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored. PMID:27539025

  14. The compensatory renin-angiotensin system in the central regulation of arterial pressure: new avenues and new challenges.

    PubMed

    Mendoza, Alberto; Lazartigues, Eric

    2015-08-01

    Hypertension is a widespread condition that affects millions of people around the world and has a major impact in public health. The classic renin-angiotensin system is a complex system comprised of multiple peptides and pathways that have been the driver of drug development over the years to control hypertension. However, there are still patients whose hypertension is very difficult to control with current drugs and strategies, thus motivating further research in this field. In the past two decades, important discoveries have expanded our knowledge of this system and new pathways are emerging that are helping us understand the complex interaction taking place not only in the periphery, but also in the central nervous system where the renin-angiotensin system is also very active. A new arm, called the ACE2/Ang-(1-7)/Mas receptor axis, was shown to exert antihypertensive properties and serve as a counterbalance to the classic ACE/angiotensin II/AT1 receptor axis, in this way modulating or even counteracting the negative effects of angiotensin II in blood pressure regulation and water retention. Modulation of this new axis through ACE2 activation, ADAM17 regulation or AT1 receptor internalization are some of the novel avenues and challenges that have the potential to become a target for new drug research and development for the treatment of hypertension.

  15. Radiological assessment and remedial action report for the ''Son of Lansdowne'' property, 186 North Lansdowne Avenue, Lansdowne, Pennsylvania

    SciTech Connect

    Smith, W.H.; Wynveen, R.A.

    1987-08-01

    This document reports the results of a radiological assessment and remedial action program conducted by Argonne National Laboratory personnel at a radioactively contaminated private residence in Lansdowne, Pennsylvania. The program was conducted on the residence at 186 Lansdowne Avenue. The survey conducted by the ANL personnel indicated that several dozen areas or spots of contamination were present on all floors and the basement of the three-story house. Contamination was found on furniture, carpeting, walls, floors, woodwork, and ceilings. Remedial action undertaken to remove the contamination ranged from scrubbing, to scraping, to shaving of wood, to removal and disposal of items and material that could not be adequately decontaminated. Outdoors, contaminated soil was removed from the backyard, and the driveway was dug up so the contaminated subsurface material could be removed. The remedial action generated quantities of radioactive waste, including four 55-gallon drums and one M-III bin (120 ft/sup 3/) containing floor tile, concrete, personal items, furniture, floor scrapings, vermiculite absorbed scrub water, and other items. In addition, there were 24 M-III bins containing approximately 112 tons of contaminated soil and rock from the two contaminated areas in the backyard and from the contaminated subsurface of the driveway. 2 refs., 39 figs., 12 tabs.

  16. 77 FR 27082 - StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ... December 28, 2010, applicable to workers and former workers of StarTek USA, Inc., Greeley, Colorado. The Department's notice of determination was published in the Federal Register on January 14, 2011 (76 FR 2717... Employment and Training Administration StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA,...

  17. Regional gravity and magnetic surveys in the Albion Mountains area of southern Idaho

    USGS Publications Warehouse

    Mabey, Don R.; Wilson, Carol W.

    1973-01-01

    Fault-bounded basins containing several thousand feet of sedimentary and volcanic rock of Cenozoic age are indicated by gravity lows in the Oakley area and in Upper-Raft River and Raft River Valleys. A gravity low and a magnetic high in the north end of Raft River Valley extends over the Cotterel Mountains and into Marsh Creek valley. These anomalies may reflect a Tertiary caldera. A gravity high and a magnetic high in the Raft River Valley south of Malta suggests a buried intrusive that may be the source of heat for the thermal waters in that area.

  18. Superfund Record of Decision (EPA Region 2): Mannheim Avenue Dump site, Galloway Township, Atlantic County, NJ. (First remedial action), September 1990. Final report

    SciTech Connect

    Not Available

    1990-09-27

    The 2-acre Mannheim Avenue Dump site is a former municipally-owned industrial waste landfill in Galloway Township, Atlantic County, New Jersey. Surrounding land use is rural residential, and many residents and facilities in the area use ground water as their drinking water supply. Beginning in 1964, drummed industrial wastes, including TCE degreasing sludge, leaded porcelain fragments, and municipal waste, were buried onsite in 35 waste mounds. In 1982, a State survey indicated the presence of many unburied and leaking drums onsite. Sampling from 1985 to 1986, revealed ground water contamination onsite. In 1989, 35 mounds of contaminated soil were disposed of offsite. The Record of Decision (ROD) addresses ground water contamination at the site. The primary contaminants of concern affecting the ground water are VOCs including benzene and TCE.

  19. Black Television: Avenue of Power

    ERIC Educational Resources Information Center

    Douglas, Pamela

    1973-01-01

    Analyzes a few of the prominent issues in black television, examining public television, commercial television, black ownership of stations, cable television, and some projections for the future. (Author/JM)

  20. Acacia Avenue and Coronation Street

    ERIC Educational Resources Information Center

    Rees, Christopher; Edmunds, Philip Turnbull

    1971-01-01

    Summarizes some of the more significant findings from a survey of two socially and economically disparate areas in Nottinghamshire, and calls for a less limited approach to university adult education in Britain. (Editor/AN)

  1. Madison Avenue vs. the Environmentalists

    ERIC Educational Resources Information Center

    Sandman, Peter M.

    1973-01-01

    The Chevron F-310 advertising program is studied as an example of large companies' use of environmental and conservation themes for attracting customers. The effects of such advertising on the society are discussed. (JP)

  2. Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

    PubMed

    Smith, Breland; Medda, Federico; Gokhale, Vijay; Dunckley, Travis; Hulme, Christopher

    2012-11-21

    With 24.3 million people affected in 2005 and an estimated rise to 42.3 million in 2020, dementia is currently a leading unmet medical need and costly burden on public health. Seventy percent of these cases have been attributed to Alzheimer's disease (AD), a neurodegenerative pathology whose most evident symptom is a progressive decline in cognitive functions. Dual specificity tyrosine phosphorylation regulated kinase-1A (DYRK1A) is important in neuronal development and plays a variety of functional roles within the adult central nervous system. The DYRK1A gene is located within the Down syndrome critical region (DSCR) on human chromosome 21 and current research suggests that overexpression of DYRK1A may be a significant factor leading to cognitive deficits in people with Alzheimer's disease (AD) and Down syndrome (DS). Currently, treatment options for cognitive deficiencies associated with Down syndrome, as well as Alzheimer's disease, are extremely limited and represent a major unmet therapeutic need. Small molecule inhibition of DYRK1A activity in the brain may provide an avenue for pharmaceutical intervention of mental impairment associated with AD and other neurodegenerative diseases. We herein review the current state of the art in the development of DYRK1A inhibitors. PMID:23173067

  3. Results of the radiological survey at the Firemen's Memorial Park and Fire Hall No. 2, Garibaldi Avenue and Kennedy Drive, Lodi, New Jersey (LJ066)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.; Crutcher, J.W. )

    1989-08-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of the gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, the Firemen's Memorial Park and Fire Hall 2, Garibaldi Avenue and Kennedy Drive, Lodi, New Jersey (LJ066) was conducted during 1987. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 4 refs., 10 figs., 3 tabs.

  4. D-subgenome bias of Xcm resistance genes in tetraploid Gossypium (cotton) suggests that polyploid formation has created novel avenues for evolution.

    PubMed

    Wright, R J; Thaxton, P M; El-Zik, K M; Paterson, A H

    1998-08-01

    A detailed RFLP map was used to determine the chromosomal locations and subgenomic distributions of cotton (Gossypium) genes/QTLs that confer resistance to the bacterial blight pathogen, Xanthomonas campestris pv. malvacearum (Xcm). Genetic mapping generally corroborated classic predictions regarding the number and dosage effects of genes conferring Xcm resistance. One recessive allele (b6) was a noteworthy exception to the genetic dominance of most plant resistance alleles. This recessive allele appeared to uncover additional QTLs from both resistant and ostensibly susceptible genotypes, some of which corresponded in location to resistance (R)-genes effective against other Xcm races. One putatively "defeated" resistance allele (B3) reduced severity of Xcm damage by "virulent" races. Among the six resistance genes derived from tetraploid cottons, five (83%) mapped to D-subgenome chromosomes-if each subgenome were equally likely to evolve new R-gene alleles, this level of bias would occur in only about 1.6% of cases. Possible explanations of this bias include biogeographic factors, differences in evolutionary rates between subgenomes, gene conversion or other intergenomic exchanges that escaped detection by genetic mapping, or other factors. A significant D-subgenome bias of Xcm resistance genes may suggest that polyploid formation has offered novel avenues for phenotypic response to selection.

  5. Three-dimensional visualization maps of suspended-sediment concentrations during placement of dredged material in 21st Avenue West Channel Embayment, Duluth-Superior Harbor, Duluth, Minnesota, 2015

    USGS Publications Warehouse

    Groten, Joel T.; Ellison, Christopher A.; Mahoney, Mollie H.

    2016-06-30

    Excess sediment in rivers and estuaries poses serious environmental and economic challenges. The U.S. Army Corps of Engineers (USACE) routinely dredges sediment in Federal navigation channels to maintain commercial shipping operations. The USACE initiated a 3-year pilot project in 2013 to use navigation channel dredged material to aid in restoration of shoreline habitat in the 21st Avenue West Channel Embayment of the Duluth-Superior Harbor. Placing dredged material in the 21st Avenue West Channel Embayment supports the restoration of shallow bay aquatic habitat aiding in the delisting of the St. Louis River Estuary Area of Concern.The U.S. Geological Survey, in cooperation with the USACE, collected turbidity and suspended-sediment concentrations (SSCs) in 2014 and 2015 to measure the horizontal and vertical distribution of SSCs during placement operations of dredged materials. These data were collected to help the USACE evaluate the use of several best management practices, including various dredge material placement techniques and a silt curtain, to mitigate the dispersion of suspended sediment.Three-dimensional visualization maps are a valuable tool for assessing the spatial displacement of SSCs. Data collection was designed to coincide with four dredged placement configurations that included periods with and without a silt curtain as well as before and after placement of dredged materials. Approximately 230 SSC samples and corresponding turbidity values collected in 2014 and 2015 were used to develop a simple linear regression model between SSC and turbidity. Using the simple linear regression model, SSCs were estimated for approximately 3,000 turbidity values at approximately 100 sampling sites in the 21st Avenue West Channel Embayment of the Duluth-Superior Harbor. The estimated SSCs served as input for development of 12 three-dimensional visualization maps.

  6. Champion Avenue School: A Historical Analysis.

    ERIC Educational Resources Information Center

    Randolph, Adah Ward

    A historical and qualitative analysis of a northern urban de facto segregated school is presented that explains the unique factors of the school's history that led to the maintenance of the school today. The focus is on the school's context, its historical and present-day leadership, and its past and present teachers. In considering the school's…

  7. Pharmaceutical technology management--profitable business avenue.

    PubMed

    Puthli, Shivanand P

    2010-01-01

    Growing research expenditure, regulatory framework and generic erosion have forced pharmaceutical companies globally to resort to pharmaceutical technology management (PTM). Indeed, the pharmaceutical industry has witnessed the impact of innovative drug delivery and device technologies and their influence on business. PTM has given a new business insight with greater profits and enhancement of product franchise. Promising breakthrough technologies have not been able to reach a commercial platform largely owing to lack of capital at the preliminary stages of the product development program. Intellectual property plays a considerable role in protecting innovative technologies. Joint ventures and strategic alliances also become important for commercializing a new technology. The synergy of PTM with options of in-licensing is expected to infuse newer opportunities to the pharmaceutical business. PMID:20017657

  8. Varroa destructor: research avenues towards sustainable control

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pollination by honeybees plays a key role in the functioning of ecosystems and optimization of agricultural yields. Severe honeybee colony losses worldwide have raised concerns about the sustainability of these pollination services. In most cases, bee morbidity appears to be the product of many inte...

  9. Passageway: An Avenue into the Future.

    ERIC Educational Resources Information Center

    Madison, Marion; Marson, Alvin; Reese, KiKi

    The PASSAGEWAY Project (Program To Assist Secondary Students in Achieving Gainful Employment for West Alabama Youth) sought to increase the academic, social, and job skills of high-risk and dropout special education students. A cooperative program of the University of West Alabama, public schools, businesses, and social service agencies, the…

  10. Future Avenues to Decrease Uremic Toxin Concentration.

    PubMed

    Vanholder, Raymond C; Eloot, Sunny; Glorieux, Griet L R L

    2016-04-01

    In this article, we review approaches for decreasing uremic solute concentrations in chronic kidney disease and in particular, in end-stage renal disease (ESRD). The rationale to do so is the straightforward relation between concentration and biological (toxic) effect for most toxins. The first section is devoted to extracorporeal strategies (kidney replacement therapy). In the context of high-flux hemodialysis and hemodiafiltration, we discuss increasing dialyzer blood and dialysate flows, frequent and/or extended dialysis, adsorption, bioartificial kidney, and changing physical conditions within the dialyzer (especially for protein-bound toxins). The next section focuses on the intestinal generation of uremic toxins, which in return is stimulated by uremic conditions. Therapeutic options are probiotics, prebiotics, synbiotics, and intestinal sorbents. Current data are conflicting, and these issues need further study before useful therapeutic concepts are developed. The following section is devoted to preservation of (residual) kidney function. Although many therapeutic options may overlap with therapies provided before ESRD, we focus on specific aspects of ESRD treatment, such as the risks of too-strict blood pressure and glycemic regulation and hemodynamic changes during dialysis. Finally, some recommendations are given on how research might be organized with regard to uremic toxins and their effects, removal, and impact on outcomes of uremic patients. PMID:26500179

  11. Spontaneous Play: An Avenue for Intellectual Development.

    ERIC Educational Resources Information Center

    Almy, Millie

    1966-01-01

    It is generally conceded that there is much for a child to learn while attending nursery school, but the teacher is often unsure as to what type of curriculum or program will best assure such learning. Specifically, although play has been part of all nursery school programs, it is questioned whether spontaneous play (that is, relatively…

  12. Additional insights. Commentary on “the musical stroop effect: opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

    PubMed

    Akiva-Kabiri, Lilach; Henik, Avishai

    2014-01-01

    In their paper "The Musical Stroop Effect: Opening a New Avenue to Research on Automatisms," Grégoire, Perruchet, and Poulin-Charronnat (2013) use a musical Stroop-like task to demonstrate the automaticity of musical note naming in musicians. In addition, the authors suggest that music training can serve as a tool in order to study the acquisition of automaticity. In the following commentary, we aim to address three main issues concerning the paper by Grégoire et al. (2013). First, we will suggest some additional interpretations of the results; specifically, we will relate to the association between music and space. Second, we will discuss a methodological issue dealing with interference, facilitation, and the role of the neutral condition. We suggest that the study by Grégoire et al. (2013) lacks a proper neutral condition and thus it is impossible to assert that the congruency effect is interference based. Third, we will discuss the authors' suggestion of using the musical Stroop effect as a tool for studying automatism. We consider the practical relevance of music training as a tool for studying the acquisition of automaticity by pointing out that music training is highly heterogeneous. PMID:24449650

  13. Additional insights. Commentary on “the musical stroop effect: opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

    PubMed

    Akiva-Kabiri, Lilach; Henik, Avishai

    2014-01-01

    In their paper "The Musical Stroop Effect: Opening a New Avenue to Research on Automatisms," Grégoire, Perruchet, and Poulin-Charronnat (2013) use a musical Stroop-like task to demonstrate the automaticity of musical note naming in musicians. In addition, the authors suggest that music training can serve as a tool in order to study the acquisition of automaticity. In the following commentary, we aim to address three main issues concerning the paper by Grégoire et al. (2013). First, we will suggest some additional interpretations of the results; specifically, we will relate to the association between music and space. Second, we will discuss a methodological issue dealing with interference, facilitation, and the role of the neutral condition. We suggest that the study by Grégoire et al. (2013) lacks a proper neutral condition and thus it is impossible to assert that the congruency effect is interference based. Third, we will discuss the authors' suggestion of using the musical Stroop effect as a tool for studying automatism. We consider the practical relevance of music training as a tool for studying the acquisition of automaticity by pointing out that music training is highly heterogeneous.

  14. 76 FR 51053 - Notice of Public Meetings, Twin Falls District Resource Advisory Council, Idaho

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    .... That afternoon, the RAC will return to the Burley Fire Conference room to discuss Wilderness and Wild... meet at the Burley BLM Fire Conference Room, located at 3630 Overland Ave., Burley, Idaho 83318....

  15. Computers: New Avenues for Engineering Students at the Community College.

    ERIC Educational Resources Information Center

    Brillhart, Lia; Shawhan, Douglas

    At Triton College, student involvement with computers as a continued, multifaceted process is considered a primary objective of the physics and engineering department. To that end, the department implemented a low cost diverse program. The computer uses presented include labs, algorithms, testing, individual projects, drills, graphics, simulation,…

  16. A new avenue for lithium: intervention in traumatic brain injury.

    PubMed

    Leeds, Peter R; Yu, Fengshan; Wang, Zhifei; Chiu, Chi-Tso; Zhang, Yumin; Leng, Yan; Linares, Gabriel R; Chuang, De-Maw

    2014-06-18

    Traumatic brain injury (TBI) is a leading cause of disability and death from trauma to central nervous system (CNS) tissues. For patients who survive the initial injury, TBI can lead to neurodegeneration as well as cognitive and motor deficits, and is even a risk factor for the future development of neurodegenerative disorders such as Alzheimer's disease. Preclinical studies of multiple neuropathological and neurodegenerative disorders have shown that lithium, which is primarily used to treat bipolar disorder, has considerable neuroprotective effects. Indeed, emerging evidence now suggests that lithium can also mitigate neurological deficits incurred from TBI. Lithium exerts neuroprotective effects and stimulates neurogenesis via multiple signaling pathways; it inhibits glycogen synthase kinase-3 (GSK-3), upregulates neurotrophins and growth factors (e.g., brain-derived neurotrophic factor (BDNF)), modulates inflammatory molecules, upregulates neuroprotective factors (e.g., B-cell lymphoma-2 (Bcl-2), heat shock protein 70 (HSP-70)), and concomitantly downregulates pro-apoptotic factors. In various experimental TBI paradigms, lithium has been shown to reduce neuronal death, microglial activation, cyclooxygenase-2 induction, amyloid-β (Aβ), and hyperphosphorylated tau levels, to preserve blood-brain barrier integrity, to mitigate neurological deficits and psychiatric disturbance, and to improve learning and memory outcome. Given that lithium exerts multiple therapeutic effects across an array of CNS disorders, including promising results in preclinical models of TBI, additional clinical research is clearly warranted to determine its therapeutic attributes for combating TBI. Here, we review lithium's exciting potential in ameliorating physiological as well as cognitive deficits induced by TBI.

  17. Towards new avenues in the management of lupus glomerulonephritis.

    PubMed

    Mok, C C

    2016-04-01

    Renal involvement in systemic lupus erythematosus (SLE) carries substantial morbidity and mortality. Conventional immunosuppressive agents (cyclophosphamide and azathioprine) have suboptimal efficacy and substantial toxicity. Mycophenolate mofetil has emerged as an alternative agent for both induction and maintenance therapy in lupus nephritis because of its reduced gonadal toxicity, despite its failure to demonstrate superiority over cyclophosphamide in pivotal studies. The calcineurin inhibitor tacrolimus has equivalent efficacy to cyclophosphamide and mycophenolate mofetil for inducing remission of lupus nephritis. Although rituximab has shown promise in refractory lupus nephritis, combining rituximab with mycophenolate mofetil as initial therapy offers no additional benefit. Considerable interethnic variation is evident in the efficacy and tolerability of the various immunosuppressive regimens, which necessitates individualized treatment and comparison of the efficacy of new regimens across different ethnic groups. For example, low-dose combinations of tacrolimus and mycophenolate mofetil seem to be more effective than pulse cyclophosphamide as induction therapy in Chinese patients. The same regimen has also been used successfully to treat refractory proliferative and membranous lupus nephritis in patients of various ethnic groups. Finally, novel serum and urinary biomarkers are being validated for diagnosis, prognostic stratification and early recognition of flares in lupus nephritis. PMID:26729459

  18. Nanodelivery: An Emerging Avenue for Nutraceuticals and Drug Delivery.

    PubMed

    Aklakur, Md; Asharf Rather, Mohd; Kumar, Neeraj

    2016-10-25

    Aquaculture has been globally recognized as the fastest growing food production sector which plays a major role in meeting the increasing demand for animal protein requirement. A consensus is growing that a dramatic increase in aquaculture is needed to supply future aquatic food needs. However, there are sustained problems with the aquaculture like disease outbreaks, chemical pollution, the environmental destruction, and inefficient feed utilization. These altogether raise question mark on sustainability of aquaculture. In spite of the several strategy adopted on national and international level, as improved laboratory facilities, diagnostic expertise, and control and therapeutic strategies in order to handle disease outbreaks more effectively. Aquaculture industry is under uncertainty and the progress has not matched that of the rapidly developing aquaculture sector. In order to control disease prevalence and ensure better health of system and sustainable production, the sector demand more technical innovation for the drug use, disease treatment, water quality management, production of tailored fish for suiting better health, productivity drive by epigenetic and nutrigenomic interaction, better breeding success by efficient delivery of maturation and spawning inducing agent, nutraceutical delivery for rapid growth promotion and culture time reduction, successful use of autotransgenic, and effective vaccine. Nanotechnology has a tremendous potential to revolutionize agriculture and allied fields including aquaculture and fisheries. For these multiple purposes effort, importance of nanotechnology and nanodelivery of drugs, vaccine, nutraceutical, inducing hormones, and growth-promoting anabolics open tremendous opportunity. The paper has been targeted to delineate the possible future application of nanodelivery for the aquaculture development.

  19. Vulnerability and Gambling Addiction: Psychosocial Benchmarks and Avenues for Intervention

    ERIC Educational Resources Information Center

    Suissa, Amnon Jacob

    2011-01-01

    Defined by researchers as "a silent epidemic" the gambling phenomenon is a social problem that has a negative impact on individuals, families and communities. Among these effects, there is exasperating evidence of comprised community networks, a deterioration of family and social ties, psychiatric co-morbidity, suicides and more recently,…

  20. "Avenue ASL:" Transforming Curriculum through Design and Innovation

    ERIC Educational Resources Information Center

    Miller, Charles; Hooper, Simon; Rose, Susan

    2008-01-01

    Between 1998 and 2002, enrollment in American Sign Language (ASL) curricula at the postsecondary level has increased 433% nationally, representing the largest enrollment percentage gain of all world languages. This unprecedented demand for ASL linguistic study has created a wide range of instructional challenges, the most pervasive of which…

  1. Gorgias on Madison Avenue: Sophistry and the Rhetoric of Advertising.

    ERIC Educational Resources Information Center

    Matcuk, Matt

    Using sophistic theory and focusing on intersections in the practice and reception of sophistry and advertising, a study analyzed a contemporary advertising campaign. A number of extrinsic similarities between sophistic and advertising rhetoric exist: their commercial basis, their popular reception as dishonest speech, and the reception of both as…

  2. Nonsteroidal anti-inflammatory drug gastropathy: new avenues for safety

    PubMed Central

    Roth, Sanford H

    2011-01-01

    Chronic oral or systemic nonselective nonsteroidal anti-inflammatory drug (NSAID) therapy, ubiquitously used by physicians to treat osteoarthritis-associated pain, is associated with a wide range of symptomatic adverse events, the most frequent and serious of which is gastropathy. Although cardiovascular and renal problems are a very real concern, they are significantly less frequent. These complications can be life-threatening in at-risk populations such as older adults, who are common users of long-term oral systemic NSAID therapy. Topical NSAID formulations deliver effective doses of analgesics directly to the affected joints, thereby limiting systemic exposure and potentially the risk of systemic adverse events, such as gastropathy and serious cardiovascular events. There are currently two topical NSAIDs approved by the US Food and Drug Administration for osteoarthritis-associated pain, as well as for the signs and symptoms of osteoarthritis. This review discusses the relative safety, and the gastrointestinal, cardiovascular, and renal risks of chronic oral or systemic NSAID therapy and topical NSAID formulations in patients with osteoarthritis. PMID:21753867

  3. Dietary delivery: A new avenue for microRNA therapeutics?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Many people carefully monitor their food choices, adhering to the philosophy that you are what you eat. Recent research adds to a new wrinkle to that old adage, suggesting that dietary small RNAs (sRNAs) can control the gene expression of the consumer and may provide an effective, noninvasive, and i...

  4. Nanodelivery: An Emerging Avenue for Nutraceuticals and Drug Delivery.

    PubMed

    Aklakur, Md; Asharf Rather, Mohd; Kumar, Neeraj

    2016-10-25

    Aquaculture has been globally recognized as the fastest growing food production sector which plays a major role in meeting the increasing demand for animal protein requirement. A consensus is growing that a dramatic increase in aquaculture is needed to supply future aquatic food needs. However, there are sustained problems with the aquaculture like disease outbreaks, chemical pollution, the environmental destruction, and inefficient feed utilization. These altogether raise question mark on sustainability of aquaculture. In spite of the several strategy adopted on national and international level, as improved laboratory facilities, diagnostic expertise, and control and therapeutic strategies in order to handle disease outbreaks more effectively. Aquaculture industry is under uncertainty and the progress has not matched that of the rapidly developing aquaculture sector. In order to control disease prevalence and ensure better health of system and sustainable production, the sector demand more technical innovation for the drug use, disease treatment, water quality management, production of tailored fish for suiting better health, productivity drive by epigenetic and nutrigenomic interaction, better breeding success by efficient delivery of maturation and spawning inducing agent, nutraceutical delivery for rapid growth promotion and culture time reduction, successful use of autotransgenic, and effective vaccine. Nanotechnology has a tremendous potential to revolutionize agriculture and allied fields including aquaculture and fisheries. For these multiple purposes effort, importance of nanotechnology and nanodelivery of drugs, vaccine, nutraceutical, inducing hormones, and growth-promoting anabolics open tremendous opportunity. The paper has been targeted to delineate the possible future application of nanodelivery for the aquaculture development. PMID:25830230

  5. DOE ZERH Case Study: Sunroc Builders, Bates Avenue, Lakeland, FL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning affordable home in the hot-humid climate that got HERS 57 without PV, with 6.5” SIP walls and 8.25” SIP roof; uninsulated slab foundation; fresh air intake; SEER 16 ducted air source heat pump.

  6. Lagrangian avenues of transport in the Earth's mantle.

    PubMed

    Schneider, Judit; Schmalzl, Joerg; Tél, Tamás

    2007-09-01

    A method of visualizing and characterizing stirring structures of high Rayleigh number geophysical flows whose time dependence is strongly aperiodic is presented. To this end, the system is leaked by defining a smaller region of the flow, so that a particle is considered to be escaped if it enters this region. By means of an ensemble of nonescaped tracers, we are able to characterize stirring and transport processes by visualizing the converging and stretching filamentations (stable and unstable manifolds) in the flow. The method indicates that the present-day Earth's mantle is not well stirred because the time that has passed since the formation of the Earth has not been long enough for the flow of the mantle to generate efficient stirring, and observations reveal indeed the existence of reservoirs of different materials.

  7. New Project Details Low-Income Schools' Avenues to Success

    ERIC Educational Resources Information Center

    Sawchuk, Stephen

    2008-01-01

    The principal of Noyes Education Campus in the District of Columbia remembers when, in exchange for hefty staff bonuses for outstanding performance, the school hosted a team of visitors armed with video cameras, tape recorders, and piles of interview questions. The focus of their queries: To what did the school attribute its success? What had made…

  8. New avenues for phase matching in nonlinear hyperbolic metamaterials

    NASA Astrophysics Data System (ADS)

    Duncan, C.; Perret, L.; Palomba, S.; Lapine, M.; Kuhlmey, B. T.; de Sterke, C. Martijn

    2015-03-01

    Nonlinear optical processes, which are of paramount importance in science and technology, involve the generation of new frequencies. This requires phase matching to avoid that light generated at different positions interferes destructively. Of the two original approaches to achieve this, one relies on birefringence in optical crystals, and is therefore limited by the dispersion of naturally occurring materials, whereas the other, quasi-phase-matching, requires direct modulation of material properties, which is not universally possible. To overcome these limitations, we propose to exploit the unique dispersion afforded by hyperbolic metamaterials, where the refractive index can be arbitrarily large. We systematically analyse the ensuing opportunities and demonstrate that hyperbolic phase matching can be achieved with a wide range of material parameters, offering access to the use of nonlinear media for which phase matching cannot be achieved by other means. With the rapid development in the fabrication of hyperbolic metamaterials, our approach is destined to bring significant advantages over conventional techniques for the phase matching of a variety of nonlinear processes.

  9. Matrix Metalloproteinases and Minocycline: Therapeutic Avenues for Fragile X Syndrome

    PubMed Central

    Siller, Saul S.; Broadie, Kendal

    2012-01-01

    Fragile X syndrome (FXS) is the most common known genetic form of intellectual disability and autism spectrum disorders. FXS patients suffer a broad range of other neurological symptoms, including hyperactivity, disrupted circadian activity cycles, obsessive-compulsive behavior, and childhood seizures. The high incidence and devastating effects of this disease state make finding effective pharmacological treatments imperative. Recently, reports in both mouse and Drosophila FXS disease models have indicated that the tetracycline derivative minocycline may hold great therapeutic promise for FXS patients. Both models strongly suggest that minocycline acts on the FXS disease state via inhibition of matrix metalloproteinases (MMPs), a class of zinc-dependent extracellular proteases important in tissue remodeling and cell-cell signaling. Recent FXS clinical trials indicate that minocycline may be effective in treating human patients. In this paper, we summarize the recent studies in Drosophila and mouse FXS disease models and human FXS patients, which indicate that minocycline may be an effective FXS therapeutic treatment, and discuss the data forming the basis for the proposed minocycline mechanism of action as an MMP inhibitor. PMID:22685676

  10. Diabetic Macular Edema: From Old Concepts to New Therapeutic Avenues

    PubMed Central

    Mansour, Ahmad M; Pulido, Jose S; Arevalo, J Fernando

    2015-01-01

    Diabetic macular edema (DME) is a significant cause of blindness in the working population and is currently challenging to treat. Current interventions include focal laser or intravitreal injections. This article outlines a new treatment protocol based on the theory that peripheral ischemia is the precursor to angiogenesis, which will ultimately gather its momentum at the fovea. Extreme peripheral light laser panretinal photocoagulation (PRP) back to the equator reduces excessive production of the vascular endothelial growth factor (VEGF) in the eye. This decreases VEGF-induced DME and provides long-term protection against the development of neovascularization. Initial exacerbation of DME often accompanies PRP. Therefore, injections of anti-VEGF agents (with or without dexamethasone implants) initially can forestall worsening of DME and prevent loss of vision. However, on the other hand, applying peripheral PRP and intraocular injections can induce posterior vitreous detachment (PVD). This could help release vitreomacular adhesions (VMA) and vitreomacular traction (VMT), thereby decreasing DME severity and improving the response to intravitreal injections. In the current approach, peripheral retinal photocoagulation should stop the drive for VEGF release; moreover, laser ablation should produce secondary, accidental, and beneficial PVD. This approach precludes focal laser therapy and paves the path for prolonged intervals between anti-VEGF therapy. PMID:27800500

  11. Advancements and Avenues in Nanophytomedicines for Better Pharmacological Responses.

    PubMed

    Saraf, Swarnlata; Gupta, Anshita; Alexander, Amit; Khan, Junaid; Jangde, Manmohan; Saraf, Shailendra

    2015-06-01

    Novel drugs delivery systems (NDDS), formulations from plant actives and extracts are still a matter of thrust and hot cake among the researchers working with phytomedicine. Novel delivery systems such as polymeric liposomes, colloidisomes, aquasomes, ethosomes, niosomes, proliposomes, phytosomes, nanoparticles, nanocapsules, nanoemulsions, microsphere and transferosomes have been proven to be a better carrier for delivery of the phyto-constituents as already done by various eminent scientists. Due to increased bioavailability, protection from toxicity, enhancement of pharmacological activity, enhancement of stability, improved tissue macrophages distribution, sustained delivery, and protection from physical and chemical degradation novel delivery systems are more suitable delivery system in compare to the conventional systems. This articled, highlight the remarkable findings in the recent past by innovators exclusively working on novel drug delivery systems for phyto-constituents. PMID:26369014

  12. Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.

    PubMed

    Chevalier, Nina; Tan, Jian K; Mason, Linda J; Robert, Remy; McKenzie, Craig I; Lim, Florence; Wong, Connie H; Macia, Laurence; Thorburn, Alison N; Russ, Brendan E; Masters, Seth L; Mackay, Charles R

    2016-09-01

    Environmental factors contribute to development of autoimmune diseases. For instance, human autoimmune arthritis can associate with intestinal inflammation, cigarette smoking, periodontal disease, and various infections. The cellular and, molecular pathways whereby such remote challenges might precipitate arthritis or flares remain unclear. Here, we used a transfer model of self-reactive arthritis-inducing CD4(+) cells from KRNtg mice that, upon transfer, induce a very mild form of autoinflammatory arthritis in recipient animals. This model enabled us to identify external factors that greatly aggravated disease. We show that several distinct challenges precipitated full-blown arthritis, including intestinal inflammation through DSS-induced colitis, and bronchial stress through Influenza infection. Both triggers induced strong IL-17 expression primarily in self-reactive CD4(+) cells in lymph nodes draining the site of inflammation. Moreover, treatment of mice with IL-1β greatly exacerbated arthritis, while transfer of KRNtg CD4(+) cells lacking IL-1R significantly reduced disease and IL-17 expression. Thus, IL-1β enhances the autoaggressive potential of self-reactive CD4(+) cells, through increased Th17 differentiation, and this influences inflammatory events in the joints. We propose that diverse challenges that cause remote inflammation (lung infection or colitis, etc.) result in IL-1β-driven Th17 differentiation, and this precipitates arthritis in genetically susceptible individuals. Thus the etiology of autoimmune inflammatory arthritis likely relates to diverse triggers that converge to a common pathway involving IL-1β production and Th17 cell distribution. PMID:27427404

  13. Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.

    PubMed

    Chevalier, Nina; Tan, Jian K; Mason, Linda J; Robert, Remy; McKenzie, Craig I; Lim, Florence; Wong, Connie H; Macia, Laurence; Thorburn, Alison N; Russ, Brendan E; Masters, Seth L; Mackay, Charles R

    2016-09-01

    Environmental factors contribute to development of autoimmune diseases. For instance, human autoimmune arthritis can associate with intestinal inflammation, cigarette smoking, periodontal disease, and various infections. The cellular and, molecular pathways whereby such remote challenges might precipitate arthritis or flares remain unclear. Here, we used a transfer model of self-reactive arthritis-inducing CD4(+) cells from KRNtg mice that, upon transfer, induce a very mild form of autoinflammatory arthritis in recipient animals. This model enabled us to identify external factors that greatly aggravated disease. We show that several distinct challenges precipitated full-blown arthritis, including intestinal inflammation through DSS-induced colitis, and bronchial stress through Influenza infection. Both triggers induced strong IL-17 expression primarily in self-reactive CD4(+) cells in lymph nodes draining the site of inflammation. Moreover, treatment of mice with IL-1β greatly exacerbated arthritis, while transfer of KRNtg CD4(+) cells lacking IL-1R significantly reduced disease and IL-17 expression. Thus, IL-1β enhances the autoaggressive potential of self-reactive CD4(+) cells, through increased Th17 differentiation, and this influences inflammatory events in the joints. We propose that diverse challenges that cause remote inflammation (lung infection or colitis, etc.) result in IL-1β-driven Th17 differentiation, and this precipitates arthritis in genetically susceptible individuals. Thus the etiology of autoimmune inflammatory arthritis likely relates to diverse triggers that converge to a common pathway involving IL-1β production and Th17 cell distribution.

  14. Avenue T: Using Film as "Entree" in Teaching about Transgender

    ERIC Educational Resources Information Center

    Walters, Andrew S.; Rehma, Kae

    2013-01-01

    Educators from a variety of disciplines include the concept of transgender and multiple gender identities in course curricula. The "T" (denoting the specific inclusion of transgender) in the popular acronym LGBT (lesbian, gay, bisexual, transgender) often is given less pedagogical attention than is sexual orientation, and the transgender…

  15. Youth Sport Programs: An Avenue to Foster Positive Youth Development

    ERIC Educational Resources Information Center

    Fraser-Thomas, Jessica L.; Cote, Jean; Deakin, Janice

    2005-01-01

    Concern about the growth in adolescent problem behaviours (e.g. delinquency, drug use) has led to increased interest in positive youth development, and a surge in funding for "after school programs." We evaluate the potential of youth sport programs to foster positive development, while decreasing the risk of problem behaviours. Literature on the…

  16. Great Decisions: Low Cost Avenue to Expanded Community

    ERIC Educational Resources Information Center

    Krebs, Virginia

    1974-01-01

    Discussed a program of group discussion, sponsored by the Foreign Policy Association, a New York-based, non-partisan organization for world affairs education, that may have all the features needed to enhance its community service involvement with a minimum of staff and expense. (Author/RK)

  17. New avenues for phase matching in nonlinear hyperbolic metamaterials.

    PubMed

    Duncan, C; Perret, L; Palomba, S; Lapine, M; Kuhlmey, B T; de Sterke, C Martijn

    2015-01-01

    Nonlinear optical processes, which are of paramount importance in science and technology, involve the generation of new frequencies. This requires phase matching to avoid that light generated at different positions interferes destructively. Of the two original approaches to achieve this, one relies on birefringence in optical crystals, and is therefore limited by the dispersion of naturally occurring materials, whereas the other, quasi-phase-matching, requires direct modulation of material properties, which is not universally possible. To overcome these limitations, we propose to exploit the unique dispersion afforded by hyperbolic metamaterials, where the refractive index can be arbitrarily large. We systematically analyse the ensuing opportunities and demonstrate that hyperbolic phase matching can be achieved with a wide range of material parameters, offering access to the use of nonlinear media for which phase matching cannot be achieved by other means. With the rapid development in the fabrication of hyperbolic metamaterials, our approach is destined to bring significant advantages over conventional techniques for the phase matching of a variety of nonlinear processes. PMID:25757863

  18. Gold-Catalyzed Cyclization Processes: Pivotal Avenues for Organic Synthesis.

    PubMed

    Kumar, Amit; Singh, Sukhdev; Sharma, Sunil K; Parmar, Virinder S; Van der Eycken, Erik V

    2016-02-01

    Over the years, gold catalysis has materialized as an incredible synthetic approach among the scientific community. Due to the trivial reaction conditions and great functional compatibility, these progressions are synthetically expedient, because practitioners can implement them to build intricate architectures from readily amassed building blocks with high bond forming indices. The incendiary growth of gold catalysts in organic synthesis has been demonstrated as one of the most prevailing soft Lewis acids for electrophilic activation of carbon-carbon multiple bonds towards a great assortment of nucleophiles. Nowadays, organic chemists consistently employ gold catalysts to carry out a diverse array of organic transformations to build unprecedented molecular architectures. Despite all these achievements and a plethora of reports, many vital challenges remain. In this account, we describe the reactivity of various gold catalysts towards cyclization processes developed over the years. These protocols give access to a wide scope of polyheterocyclic structures, containing different medium-sized ring skeletons. This is interesting, as the quest for highly selective reactions to assemble diversely functionalized products has attracted much attention. We envisage that these newly developed chemo-, regio-, and diastereoselective protocols could provide an expedient route to architecturally cumbersome heterocycles of importance for the pharmaceutical industry.

  19. Exploration of the Emotional Avenues of Career Change.

    ERIC Educational Resources Information Center

    Chope, Robert C.

    The emotional fallout from rapid, dramatic job market changes can severely and adversely affect the job search and job change process. It can cause inappropriate, precipitous emotional reactions that can block a job seeker's effectiveness at different times and stages of each job search. This paper demonstrates how individuals can find their way…

  20. The Role of Women in Television: Avenues for Change.

    ERIC Educational Resources Information Center

    Britton, Helen Ann

    During the 1960's educators became aware that the role models presented by educational materials to minority children helped shape the role that the children ultimately occupied in the society. Similarly, it has been observed that the media presents a negative image of women which may result in unfulfilling role adaptation, a process which becomes…

  1. Molecular marker systems in insects: current trends and future avenues.

    PubMed

    Behura, Susanta K

    2006-10-01

    Insects comprise the largest species composition in the entire animal kingdom and possess a vast undiscovered genetic diversity and gene pool that can be better explored using molecular marker techniques. Current trends of application of DNA marker techniques in diverse domains of insect ecological studies show that mitochondrial DNA (mtDNA), microsatellites, random amplified polymorphic DNA (RAPD), expressed sequence tags (EST) and amplified fragment length polymorphism (AFLP) markers have contributed significantly for progresses towards understanding genetic basis of insect diversity and for mapping medically and agriculturally important genes and quantitative trait loci in insect pests. Apart from these popular marker systems, other novel approaches including transposon display, sequence-specific amplification polymorphism (S-SAP), repeat-associated polymerase chain reaction (PCR) markers have been identified as alternate marker systems in insect studies. Besides, whole genome microarray and single nucleotide polymorphism (SNP) assays are becoming more popular to screen genome-wide polymorphisms in fast and cost effective manner. However, use of such methodologies has not gained widespread popularity in entomological studies. The current study highlights the recent trends of applications of molecular markers in insect studies and explores the technological advancements in molecular marker tools and modern high throughput genotyping methodologies that may be applied in entomological researches for better understanding of insect ecology at molecular level.

  2. International study tours: an avenue for personal growth.

    PubMed

    O'Reilly, Frances L; McCaw, William; Matt, John J; Kero, Patty

    2013-01-01

    This article consists of four integral parts of a complex process leading to successful implementation of international study tours. Our role as faculty members, in the development of these study tours, began with the proactive, reflective practice of examining our cultural experiences, perceptions, and understandings of our cultural knowledge, dispositions, and skills. Through these tours, educators from other countries and cultures come to The University of Montana and experience a collaboration of ideas and acquire a better understanding of education in the United States. To be successful these study tours need to go beyond content and include a variety of less tangible aspects ranging from the Initial Request for Proposals to the culminating activities. These study tours have led to the empowerment of educational leaders becoming instruments of positive change in their homeland. In turn, the relationships developed have transformed the faculty presenters and the institution in ways that are both measurable and immeasurable. Human relationships based on mutual respect and dignity underlie the success of educational tours.

  3. Community-Based Education and Rural Development. Site Visit to Nebraska. Rural Funders Working Group Case Study.

    ERIC Educational Resources Information Center

    Doeden, Carol Lee

    In September 2000, grantmakers from around the country traveled to three Nebraska communities--Albion, Crete, and Henderson--to see how community-based education can positively affect the economic, environmental, and cultural development of a rural community. In Albion, the school is an open laboratory in which students, teachers, and parents work…

  4. Mesenchymal stem cell-derived exosomes: A novel potential therapeutic avenue for cardiac regeneration.

    PubMed

    Safari, S; Malekvandfard, F; Babashah, S; Alizadehasl, A; Sadeghizadeh, M; Motavaf, M

    2016-01-01

    Coronary artery diseases (CADs) represent a significant cause of death worldwide. During recent decades the rate of cardiovascular mortality has been declined as a result of modern medicine and surgery. However, despite the fact that cardiac cells, including cardiomyocytes (CMCs), vascular smooth muscle cells (VSMC) and vascular endothelial cells (VEC), can be regenerated by cardiac adult stem cell, the regenerative capacity of these cells are limited and inadequate to functionally regenerate heart damaged tissue. Thus, growth reserve of the heart fails to restore the structural integrity of the myocardium after infarction and healing is associated with scar formation. An explanation for this is that cardiac reside stem cells are present throughout the infarction site but die rapidly by apoptosis. Furthermore, microenvironment surrounding the damage site is not promising for the cells survival and renewal. Hence, recent advances in the stem cell therapy have emerged as an attractive approach to replace the lost cells. In this context, mesenchymal stem cells (MSCs) has considered as one of the most promising candidates for regeneration of cardiac cells, lost upon injury. The regenerative capacity of MSCs has primarily been centered on the hypothesis that these cells would engraft, differentiate and replace damaged cardiac cells. However, experimental and clinical observations so far have failed to establish if this differentiated is considerably relevant to MSCs cardiac regenerative properties. Recent reports have suggested that these therapeutic properties, at least in part, are mediated by paracrine factors released from MSCs. This review provides a concise summary of current evidences supporting the paracrine hypothesis of MSCs. In particular, the scope of this review focuses on the role of MSC-derived exosome (MSC-EXs) as a therapeutic modality for the treatment of CADs, particularly ischemic myocardial dysfunctions. PMID:27453275

  5. Rapid synthesis of barium titanate microcubes using composite-hydroxides-mediated avenue

    SciTech Connect

    He, Xi; Ouyang, Jing Jin, Jiao; Yang, Huaming

    2014-04-01

    Highlights: • Barium titanate oxides microcubes can be synthesized within 1 min. • Composite-hydroxides-mediated strategy provided a possible large scale production. • BST obtained in the strategy showed fairly good crystallinity and tetragonality. - Abstract: This paper reports the rapid synthesis of barium titanate (BaTiO{sub 3}, BTO) microcubes via composite-hydroxides-mediated reaction within 1 min. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersion spectrum (EDS) results confirmed both cubic and tetragonal lattices in the sample and the uniform microcubes with an average size of 1 μm. Ultraviolet–visible (UV–vis) spectrum indicated that the band gap of the BTO powder was 3.05 eV. Ferroelectric polarization vs. electric field (P–E) tests showed that the ferroelectric domains had formed in the as-synthesized BTO microcubes and sintered ceramics. BTO ceramics sintered at 1100 °C for 3 h showed fairly good tetragonality and possessed a maximum polarization of 0.21 μC/cm{sup 2}, indicating that the sintering temperature for the BTO powders prepared via this method was relatively low. The process and equipment reported herein provided a potential method for the rapid synthesis of titanate based perovskites.

  6. Heterogeneous reactions of glyoxal on mineral particles: A new avenue for oligomers and organosulfate formation

    NASA Astrophysics Data System (ADS)

    Shen, Xiaoli; Wu, Huihui; Zhao, Yue; Huang, Dao; Huang, Liubin; Chen, Zhongming

    2016-04-01

    Glyoxal (GL) plays a crucial role in the formation of secondary organic aerosols (SOA), because it is highly water soluble and capable of oligomerization. This is the first study to describe irreversible heterogeneous reactions of GL on clean and acidic gas-aged SiO2, α-Al2O3, and CaCO3 particles, as models of real mineral particles, at various relative humidity and without irradiation and gas phase oxidants. A series of products, including oligomers, organosulfates, and organic acids, which contribute to SOA formation, were produced. GL uptake on SO2-aged α-Al2O3 enabled the oxidation of surface S(IV) to S(VI). The presence of adsorbed water on particles favored GL uptake and the formation of oligomers and organosulfate, but it suppressed organic acid formation. In addition, the aging process enhanced the positive effect of adsorbed water on GL uptake. These findings will further our understanding of the GL sink and SOA sources in the atmosphere.

  7. Pendular proteins in gases and new avenues for characterization of macromolecules by ion mobility spectrometry

    PubMed Central

    Shvartsburg, Alexandre A.; Noskov, Sergei Y.; Purves, Randy W.; Smith, Richard D.

    2009-01-01

    Polar molecules align in electric fields when the dipole energy (proportional to field intensity E × dipole moment p) exceeds the thermal rotational energy. Small molecules have low p and align only at inordinately high E or upon extreme cooling. Many biomacromolecules and ions are strong permanent dipoles that align at E achievable in gases and room temperature. The collision cross-sections of aligned ions with gas molecules generally differ from orientationally averaged quantities, affecting ion mobilities measured in ion mobility spectrometry (IMS). Field asymmetric waveform IMS (FAIMS) separates ions by the difference between mobilities at high and low E and hence can resolve and identify macroion conformers based on the mobility difference between pendular and free rotor states. The exceptional sensitivity of that difference to ion geometry and charge distribution holds the potential for a powerful method for separation and characterization of macromolecular species. Theory predicts that the pendular alignment of ions in gases at any E requires a minimum p that depends on the ion mobility, gas pressure, and temperature. At ambient conditions used in current FAIMS systems, p for realistic ions must exceed ≈300–400 Debye. The dipole moments of proteins statistically increase with increasing mass, and such values are typical above ≈30 kDa. As expected for the dipole-aligned regime, FAIMS analyses of protein ions and complexes of ≈30–130 kDa show an order-of-magnitude expansion of separation space compared with smaller proteins and other ions. PMID:19351899

  8. Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

    PubMed

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P; Thorn, Katherine J; Christianson, David W

    2011-08-11

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of α,α-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2-methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional α-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase.

  9. A microbial avenue to cell cycle control in the plant superkingdom.

    PubMed

    Tulin, Frej; Cross, Frederick R

    2014-10-01

    Research in yeast and animals has resulted in a well-supported consensus model for eukaryotic cell cycle control. The fit of this model to early diverging eukaryotes, such as the plant kingdom, remains unclear. Using the green alga Chlamydomonas reinhardtii, we developed an efficient pipeline, incorporating robotics, semiautomated image analysis, and deep sequencing, to molecularly identify >50 genes, mostly conserved in higher plants, specifically required for cell division but not cell growth. Mutated genes include the cyclin-dependent kinases CDKA (resembling yeast and animal Cdk1) and the plant-specific CDKB. The Chlamydomonas cell cycle consists of a long G1 during which cells can grow >10-fold, followed by multiple rapid cycles of DNA replication and segregation. CDKA and CDKB execute nonoverlapping functions: CDKA promotes transition between G1 and entry into the division cycle, while CDKB is essential specifically for spindle formation and nuclear division, but not for DNA replication, once CDKA-dependent initiation has occurred. The anaphase-promoting complex is required for similar steps in the Chlamydomonas cell cycle as in Opisthokonts; however, the spindle assembly checkpoint, which targets the APC in Opisthokonts, appears severely attenuated in Chlamydomonas, based on analysis of mutants affecting microtubule function. This approach allows unbiased integration of the consensus cell cycle control model with innovations specific to the plant lineage.

  10. Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier

    PubMed Central

    Villa, Carlos H; Pan, Daniel C; Zaitsev, Sergei; Cines, Douglas B; Siegel, Donald L; Muzykantov, Vladimir R

    2015-01-01

    For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics, biodistribution, controlled release and pharmacodynamics. Approaches include encapsulation of drugs within erythrocytes, as well as coupling of drugs onto the red cell surface. This review focuses on the latter approach, and examines the delivery of red blood cell (RBC)-surface-bound anti-inflammatory, anti-thrombotic and anti-microbial agents, as well as RBC carriage of nanoparticles. Herein, we discuss the progress that has been made in surface loading approaches, and address in depth the issues relevant to surface loading of RBC, including intrinsic features of erythrocyte membranes, immune considerations, potential surface targets and techniques for the production of affinity ligands. PMID:26228773

  11. Traversing the Avenues of Change: The Difficult Road of Teacher Education Reform.

    ERIC Educational Resources Information Center

    Beck, Judy; Shanks, Joyce

    This case study examines programmatic change over two years of reforming a teacher education program. Two teacher educators kept ongoing journals of events, reflecting on program faculty's work and progress in supporting change. Early in the process, their journals highlighted labor intensification, with faculty members facing multiple…

  12. Can the american high school become an avenue of advancement for all?

    PubMed

    Balfanz, Robert

    2009-01-01

    As the twenty-first century opens, says Robert Balfanz, the United States is developing a deep social consensus that American high schools should ensure that all adolescents graduate from high school prepared for postsecondary schooling and training. Balfanz asks how well high schools are succeeding in this mission and whether they can ultimately fulfill it. Balfanz first surveys the structure and demographics of today's high schools. Forty percent of white students attend high schools that are 90 percent or more white, while roughly one-third of Latino and African American students attend high schools that are 90 percent or more minority. Minority students are also much more likely than white students to attend high schools that confront the challenges of concentrated poverty. In predominantly white, affluent suburban school districts, nearly every student arrives ready for high school work and then graduates. In all-minority inner city schools in high-poverty neighborhoods, most entering students lack a good middle school education and only half to two-thirds graduate. With only a third to a half of high school graduates today prepared to succeed in college, how likely is it that American high schools will succeed in their mission of preparing all students for additional schooling or training? Balfanz argues that reforms over the past twenty-five years offer some hope. The standards and accountability movement has made the American high school a more focused and academic place. College preparatory course-taking has increased substantially, as has standardized testing. Mandatory exit exams have been imposed. And during the past decade, in particular, reformers have made a concerted effort to improve the low-performing high schools that serve low-income and minority students. Investments by the federal government and by foundations have led to the development of several types of reforms that have been proven effective, thus raising hopes that the nation's lowest-performing high schools can better serve their students. Still, the American high school has a considerable way to go to be able to prepare all students for further schooling or training. To advance all its students, it must find a way to bring to scale the methods and mechanisms, conditions, and know-how that have enabled a few low-performing high schools to achieve this transformation.

  13. Hazelwood Interim Storage Site environmental report for calendar year 1992, 9200 Latty Avenue, Hazelwood, Missouri

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Hazelwood Interim storage Site (HISS) and surrounding area, provides the results for 1992, and discusses applicable environmental standards and requirements with which the results were compared. HISS is located in eastern Missouri in the City of Hazelwood (St. Louis County) and occupies approximately 2.2 ha (5.5 acres). Environmental monitoring of HISS began in 1984 when the site was assigned to the US Department of Energy (DOE) as part of the decontamination research and development project authorized by Congress under the 1984 Energy and Water Development Appropriations Act. DOE placed responsibility for HISS under the Formerly Utilized Sites Remedial Action Program (FUSRAP), which was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. In 1992 there were no environmental occurrences or unplanned contaminant releases as defined in DOE requirements and in the Superfund Amendment and Reauthorization Act (SARA) Title III of CERCLA.

  14. Arrhythmogenic right ventricular dysplasia/cardiomyopathy: new avenues for diagnosis and treatment

    PubMed Central

    van der Wall, E.E.; Bootsma, M.; Wellens, H.J.J.; Bax, J.J.; de Roos, A.; Schalij, M.J.

    2003-01-01

    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a heart muscle disorder of unknown course that is characterised pathologically by fatty or fibrofatty replacement of the right ventricular myocardium and electrical instability. Clinical manifestations include structural and functional malformations of the right ventricle, electrocardiographic abnormalities, and presentation of ventricular tachycardias with left bundle branch pattern or sudden death. The disease is often familial with an autosomal inheritance. In addition to right ventricular dilatation, right ventricular aneurysms are typical deformities of ARVD/C and they are distributed in the so-called 'triangle of dysplasia', i.e. the right ventricular outflow tract, apex and infundibulum. Ventricular aneurysms at these sites can be considered highly suggestive for ARVD/C. Another typical hallmark of ARVD/C is fatty or fibrofatty infiltration of the right ventricular free wall with potential extension to the left ventricle. These functional and morphological characteristics are relevant to clinical imaging investigations such as contrast angiography, echocardiography, radionuclide angiography, ultrafast-computed tomography and magnetic resonance (MR) imaging. Among these techniques, MR imaging allows the most comprehensive assessment of the heart, in particular because it provides functional and flow-dynamic information in addition to anatomic images. Furthermore, MR imaging offers the specific advantage of visualising adipose infiltration as a bright signal of the right ventricular myocardium. Non-pharmacological treatment by radio-frequency ablation and implantable defibrillators will play an increasing role in the treatment of patients with ARVD/C, especially in case of drug ineffectivity. Despite new diagnostic and therapeutic approaches in ARVD/C, there remain many unanswered issues since the current guidelines present criteria that are highly specific but lack sensitivity. Therefore, optimal assessment of diagnostic criteria would require a prospective evaluation from a large population obtained by an international registry. ImagesFigure 1Figure 2 PMID:25696140

  15. Technology: Student Animation Projects: An Avenue to Promote Creativity and Learning

    ERIC Educational Resources Information Center

    Siegle, Del

    2014-01-01

    Using readily available technology, students of all ages can easily create impressive animated products. Animation allows educators to capitalize on the natural desire that students of all ages hold to tell stories and share their understanding of the world. In the course of planning their animations, students conduct research on topics, organize…

  16. Art as an Avenue to Science Literacy: Teaching Nanotechnology through Stained Glass

    ERIC Educational Resources Information Center

    Duncan, Kimberly A.; Johnson, Chris; McElhinny, Kyle; Ng, Steve; Cadwell, Katie D.; Zenner Petersen, Greta M.; Johnson, Angela; Horoszewski, Dana; Gentry, Ken; Lisensky, George; Crone, Wendy C.

    2010-01-01

    Nanoscale science and engineering (NSE) and nanotechnology are emerging fields that have captured the attention of scientists and engineers, as well as mainstream media. However, the general public is relatively unaware of NSE, and schools (both K-12 and undergraduate institutions) rarely include nanotechnology as part of their curriculum. To help…

  17. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues.

    PubMed

    Obulesu, M; Rao, Dowlathabad Muralidhara

    2011-01-01

    Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms. These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtisufolia (Sicklepod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), and Salvia officinalis (Garden sage, common sage). PMID:21716802

  18. On Avenues to Kindling Wide Interests in the Elementary School: Knowledges and Values.

    ERIC Educational Resources Information Center

    Brandwein, Paul

    1987-01-01

    A curriculum model is presented for stimulating wide interests at the elementary level, to develop a student pool that would sustain a nationwide residential high school for the gifted. The model presents 16 conceptual schemes for developing curricula in social sciences, humanities and sciences. (Author/KM)

  19. Electric Avenue. A Utility Company's Work Experience Program Broadens Opportunities for Students.

    ERIC Educational Resources Information Center

    Ingles, Pat

    1994-01-01

    A job skills partnership between Southern California Edison Company and local high schools pairs juniors and seniors with journeyworker mentors for a year, experiencing six-week rotations in maintenance, operations, administration, warehouse, and technical occupations. (JOW)

  20. Assessment of stricturing Crohn's disease: Current clinical practice and future avenues

    PubMed Central

    Bettenworth, Dominik; Nowacki, Tobias M; Cordes, Friederike; Buerke, Boris; Lenze, Frank

    2016-01-01

    Crohn’s disease (CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy (anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of non-invasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. PMID:26811643

  1. Holidays in the Public School Kindergarten: An Avenue for Emerging Religious and Spiritual Literacy.

    ERIC Educational Resources Information Center

    Myers, Michal Elaine; Myers, Barbara Kimes

    2002-01-01

    Addresses holidays in the curriculum and concerns raised for educators about how to be inclusive and recognize students' different cultures. Presents a sample approach to exploring holidays in the classroom, including techniques for brainstorming, celebration activities, children's individual experiences, expanding experiences, engaging families,…

  2. Aggression, Violence and Injury in Minor League Ice Hockey: Avenues for Prevention of Injury

    PubMed Central

    Cusimano, Michael D.; Ilie, Gabriela; Mullen, Sarah J.; Pauley, Christopher R.; Stulberg, Jennifer R.; Topolovec-Vranic, Jane; Zhang, Stanley

    2016-01-01

    Background In North America, more than 800,000 youth are registered in organized ice hockey leagues. Despite the many benefits of involvement, young players are at significant risk for injury. Body-checking and aggressive play are associated with high frequency of game-related injury including concussion. We conducted a qualitative study to understand why youth ice hockey players engage in aggressive, injury-prone behaviours on the ice. Methods Semi-structured interviews were conducted with 61 minor ice hockey participants, including male and female players, parents, coaches, trainers, managers and a game official. Players were aged 13–15 playing on competitive body checking teams or on non-body checking teams. Interviews were manually transcribed, coded and analyzed for themes relating to aggressive play in minor ice hockey. Results Parents, coaches, teammates and the media exert a large influence on player behavior. Aggressive behavior is often reinforced by the player’s social environment and justified by players to demonstrate loyalty to teammates and especially injured teammates by seeking revenge particularly in competitive, body-checking leagues. Among female and male players in non-body checking organizations, aggressive play is not reinforced by the social environment. These findings are discussed within the framework of social identity theory and social learning theory, in order to understand players’ need to seek revenge and how the social environment reinforces aggressive behaviors. Conclusion This study provides a better understanding of the players’ motivations and environmental influences around aggressive and violent play which may be conducive to injury. The findings can be used to help design interventions aimed at reducing aggression and related injuries sustained during ice hockey and sports with similar cultures and rules. PMID:27258426

  3. Molecular epidemiology in cancer risk assessment and prevention: recent progress and avenues for future research.

    PubMed Central

    Wogan, G N

    1992-01-01

    Molecular epidemiology is increasingly being applied in studies of cancer risks derived from exposure to environmental carcinogens of both endogenous and exogenous origins. Analytical methods have been developed that are capable of detecting and quantifying levels of covalent adducts of several important classes of carcinogens with cellular DNA and blood proteins. Methods of sufficient sensitivity and specificity to detect ambient levels of exposure are in current use. These are being used in studies related to tobacco use (polycyclic aromatic hydrocarbons, aromatic amines, tobacco-specific nitrosamines); dietary exposures (aflatoxins, N-nitrosamines, heterocyclic amines); medicinal exposures (cisplatin, alkylating agents, 8-methoxypsoralen, ultraviolet photoproducts); occupational exposures (aromatic amines, polycyclic aromatic hydrocarbons, oxides of ethylene and styrene, and vinyl chloride); and oxidative damage (8-hydroxyguanine, thymine glycol). Methodologic improvements together with their expanded use in feasibility studies continue to produce results that support the validity of this approach for detecting and quantifying exposure to carcinogens. Genetic markers are also being used to detect early biological responses in efforts to link carcinogen exposure to initiating events in the carcinogenesis process. These include, in addition to traditional cytogenetic markers (e.g., chromosomal aberrations, sister chromatid exchange, micronuclei), other alterations in chromosomal structure such as restriction fragment length polymorphisms, loss of heterozygosity, and translocation markers. Specific genetic changes have recently been identified as critical molecular events in the initiation and development of many cancers. Important among these are activation of oncogenes, especially those of the ras family, and inactivation of tumor-suppressor genes (e.g., p53 and Rb) by point mutations and/or chromosomal deletions and other structural changes. Although some of these changes are known to occur in chemically induced tumors of experimental animals, the possible role of chemical carcinogens in the induction of genetic abnormalities in human cancers has yet to be determined. Continuing investigations employing the methods of molecular epidemiology promise to provide further evidence concerning these relationships. Future investigations employing newly developed molecular biological methods, in particular those based on polymerase chain reaction amplification of DNA, to identify alterations in DNA and chromosomal structure, combined with methods for characterizing exposure to carcinogens and early effects, have great potential for further elucidating the role of genotoxic agents in the etiology of human cancers and also for the development of strategies for their prevention. PMID:1486846

  4. Grassland-cropping rotations: An avenue for agricultural diversification to reconcile high production with environmental quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity...

  5. Avenues and incentives for commercial use of a low-gravity environment

    NASA Technical Reports Server (NTRS)

    Brown, R. L.; Zoller, L. K.

    1981-01-01

    The scientific and commercial utilization of the low-g environments for materials research and for process and product development is considered. Any products of commercial interest which necessitate processing in space will probably be low volume, high value items. To encourage the commercialization of materials processing in low-g, NASA, in parallel with establishing and demonstrating the scientific/technological precepts for analyzing and using a low-g environment, is establishing the legal and management mechanisms to share in the cost and risk of early commercial ventures, and is now working with commercial firms on a case-by basis to explore applications of this new technology to specific needs of the company.

  6. [Media coverage of suicide: From the epidemiological observations to prevention avenues].

    PubMed

    Notredame, Charles-Édouard; Pauwels, Nathalie; Walter, Michel; Danel, Thierry; Vaiva, Guillaume

    2015-12-01

    Media coverage of suicide can result in increased morbi-mortality suicidal rates, due to an imitation process in those who are particularly vulnerable. This phenomenon is known as "Werther effect". Werther effect's magnitude depends on several qualitative and quantitative characteristics of the media coverage, in a dose-effect relationship. An extensive (in terms of audience and history repetition) and salient coverage (glorification of suicide, description of the suicidal method, etc.) increases the risk of contagion. Celebrities' suicide is particularly at risk of Werther effect. Media may also have a preventive role with respect to suicide. Indeed, according to "Papageno effect", journalists could, under certain conditions, help preventing suicide when reporting suicide stories. Two main theories in the field of social psychology have been proposed to account for Werther and Papageno effects: social learning theory and differential identification. Identification of Werther and Papageno effects uncovers new responsibilities and potentialities for the journalists in terms of public health. Their description provides a basis for promising targeted prevention actions. PMID:26358670

  7. Public avenues to private spaces: Democratic politics and the control of automobile pollution

    SciTech Connect

    Rajan, S.C.

    1994-01-01

    Automobile pollution policy is an institutional concern because it represents the political problem of addressing one of the ill-effects of mass driving within urban regions. In the United States, where automobility is most pervasive, the social and cultural institutions that make driving an ineluctable feature of everyday life tend to be taken for granted. On the one hand, an idealogy of individualism appears to forestall critical discussion on these aspects within civil society; on the other, reliance on technological solutions and a prevailing culture of interest-group politics help contract the space for normative reasoning within policy discourse. Ironically, though, the more people drive, the more [open quotes]auto[close quotes]-inflicted the problems of air pollution, and the more likely it is that the contradictions of these non-participatory and technocratic forms could generate crises of policy. The predicament of automobile pollution policy then comprises a paralysis in the state's continued capacity to response to what it perceives to be a double-gesture made by its citizens; they demand clean air but are unwilling to take responsibility for achieving it, especially if it involves setting limits on automobile usage. Using both theoretical arguments and empirical and historical evidence from California, this dissertation argues that official readings of automobile pollution control are constricted because they rely on an individualist metaphor which only generates elaborate techniques of risk management in response, thus moving away from a shared public effort towards normative discourse. Yet, it its also critical of approaches that would shift the blame to individual motorists and their vehicles by implying that the problem arises from the employment of a few [open quotes]gross emitters[close quotes] that need to be selectively targeted.

  8. The Importance of Acidification in Atopic Eczema: An Underexplored Avenue for Treatment

    PubMed Central

    Panther, David J.; Jacob, Sharon E.

    2015-01-01

    Atopic dermatitis is a form of dermatitis commonly seen in children and adults. Its pathophysiology is complex and is centered on the barrier function of the epidermis. An important aspect of the skin’s barrier is pH, which in turn affects a number of parameters such as the skin flora, protease function, and mediators of inflammation and pruritus. Normal pH for non-neonatal skin is acidic and ranges from 4 to 6. Skin pH in atopic dermatitis patients is often increased into the neutral to basic range, and the resulting cascade of changes contributes to the phenotype of atopic dermatitis. Therefore, the maintenance of normal skin pH remains an important topic in understanding and treating atopic dermatitis. This article will review skin pH and its impact on normal barrier function, pathological pH changes in atopic dermatitis, and the therapeutic considerations related to restoring and maintaining pH balance. PMID:26239459

  9. Snow flake shaped gold nanostructures templated on graphene: an avenue to fabricate novel nano electronic devices

    NASA Astrophysics Data System (ADS)

    Jasuja, Kabeer; Berry, Vikas

    2009-03-01

    Non spherical gold nanoparticles such as rods, multipods, polygons, cubes, stars and branched nanostructures have generated significant research attention in the past few years. Such anisotropic nano structures have been shown to exhibit size and shape dependent properties which are either significantly different or highly pronounced from their spherical counterparts. The unique properties of anisotropic nanostructures (such as localized surface plasmon resonance and surface enhanced fluorescence) make these ideal candidates for a broad range of emerging applications in photonics, opto-electronics, biomedical labeling, sensing and imaging. One of the foremost challenges in utilizing such properties is integrating the anisotropic gold nanostructures into devices which can justifiably tap these properties. Here we demonstrate a simple colloidal synthetic route that results in the formation of snow-flake shaped nanostructures of gold (Au SFs) templated on the nano-sheets of Graphene-oxide(GO). Graphene nanosheets have generated renewed interest in recent years due to their unique 2-dimensional nature and associated electronic, physical and chemical properties. An assembly of Au SFs supported on GO sheets will not only give way to the next generation electronic and optoelectronic nanodevices but will also find wide ranging applications in a number of industrially relevant reactions such as catalysis, fuel cell technology and pollution control.

  10. Image of Women in Advertisements: A Preliminary Study of Avenues for Change.

    ERIC Educational Resources Information Center

    Butler-Paisley, Matilda, Ed.; And Others

    The Center for Research on Women (CROW) at Stanford University along with the Communication Department, the Psychology Department, and the School of Education conducted a study on the image of women in advertising and suggested ways to improve women's image in the advertising media. With the objective of sponsoring some alternatives to expedite…

  11. DOE ZERH Case Study: Heirloom Design Build, Euclid Avenue, Atlanta, GA

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning custom home in the mixed-humid climate that got a HERS 50 without PV, with 2x6 16” on center walls with R-19 ocsf; basement with R-28 ccsf, R-5 rigid foam under slab; sealed attic with R-28 ocsf under roof deck; 22.8 SEER; 12.5 HSPF heat pump.

  12. Non-Verbal Communication Training: An Avenue for University Professionalizing Programs?

    ERIC Educational Resources Information Center

    Gazaille, Mariane

    2011-01-01

    In accordance with today's workplace expectations, many university programs identify the ability to communicate as a crucial asset for future professionals. Yet, if the teaching of verbal communication is clearly identifiable in most university programs, the same cannot be said of non-verbal communication (NVC). Knowing the importance of the…

  13. Ike and the GOP in 1956: Madison Avenue Comes to the Aid of the Party.

    ERIC Educational Resources Information Center

    Allen, Craig M.

    This paper argues that Dwight Eisenhower's use of television in the political campaign in 1956 helped mark the rise of the centralized presidential campaign strategy. To determine the impact of television on this campaign and describe the campaign's inner workings, the paper recounts (1) the Republican dilemma over the use of television and the…

  14. Free-electron lasers: new avenues in molecular physics and photochemistry.

    PubMed

    Ullrich, Joachim; Rudenko, Artem; Moshammer, Robert

    2012-01-01

    Free-electron lasers are fourth-generation light sources that deliver extremely intense (>10(12) photons per pulse), ultrashort (∼10(-14) s = 10 fs) light pulses at up to kilohertz repetition rates with unprecedented coherence properties and span a broad wavelength regime from soft (∼10 eV) to hard X-ray energies (∼15 keV). They thus enable a whole suite of novel experiments in molecular physics and chemistry: Inspecting radiation-induced reactions in cold molecular ions provides unprecedented insight into the photochemistry of interstellar clouds and upper planetary atmospheres; double core-hole photoelectron spectroscopy offers enhanced sensitivity for chemical analysis; the dynamics of highly excited molecular states, pumped by vacuum ultraviolet pulses, can be inspected; and vacuum ultraviolet or X-ray probe pulses generally hold the promise to trace chemical reactions along an entire reaction coordinate with atomic spatial and temporal resolution. This review intends to provide a first overview on upcoming possibilities, emerging technologies, pioneering results, and future perspectives in this exciting field.

  15. Binding of [alpha, alpha]-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design

    SciTech Connect

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P.; Thorn, Katherine J.; Christianson, David W.

    2011-10-21

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of {alpha},{alpha}-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2-methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional {alpha}-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase.

  16. New research avenues in toxicology: 7-gas N-Gas Model, toxicant suppressants, and genetic toxicology.

    PubMed

    Levin, B C

    1996-12-31

    Three research areas -- a 7-gas N-Gas Model, toxicant suppressants, and genetic toxicology -- are presented as new research approaches in toxicology. The current 6-gas N-Gas Model predicts the toxic potency of the combustion products of materials based on the toxicological interactions of the fire gases carbon monoxide (CO), carbon dioxide (CO2), low oxygen (O2) concentrations, hydrogen cyanide (HCN), hydrogen chloride, and hydrogen bromide. The present research includes nitrogen dioxide (NO2) in a new 7-gas model which incorporates the synergistic effects of NO2 and CO2, the antagonistic effects of NO2 and HCN, and the additive effects of NO2 with CO and low O2. The area of toxicant suppressants concerns chemicals, which when added to a material, will inhibit or reduce the concentration of a specific toxic gas normally generated during thermal decomposition of that material. The effectiveness of this approach was demonstrated at the US National Institute of Standards and Technology when HCN generation was reduced by 90% and the resultant toxicity of the combustion products was lowered by 50% when a flexible polyurethane (FPU) foam was treated with 0.1% (by weight) cuprous oxide (Cu2O). Although melamine-treated FPU foams are being promoted as more fire safe than standard foams, a melamine-treated foam generated 10 times more HCN than a foam without melamine. The addition of Cu2O to this melamine foam also reduced the HCN generation by 90%. The genetic toxicology research entails the examination of DNA damage that results from the exposure of human cells to various environmental toxicants and gases.

  17. Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues

    PubMed Central

    Konar, Arpita; Singh, Padmanabh; Thakur, Mahendra K.

    2016-01-01

    Age-associated cognitive decline is an inevitable phenomenon that predisposes individuals for neurological and psychiatric disorders eventually affecting the quality of life. Scientists have endeavored to identify the key molecular switches that drive cognitive decline with advancing age. These newly identified molecules are then targeted as recovery of cognitive aging and related disorders. Cognitive decline during aging is multi-factorial and amongst several factors influencing this trajectory, gene expression changes are pivotal. Identifying these genes would elucidate the neurobiological underpinnings as well as offer clues that make certain individuals resilient to withstand the inevitable age-related deteriorations. Our laboratory has focused on this aspect and investigated a wide spectrum of genes involved in crucial brain functions that attribute to senescence induced cognitive deficits. We have recently identified master switches in the epigenome regulating gene expression alteration during brain aging. Interestingly, these factors when manipulated by chemical or genetic strategies successfully reverse the age-related cognitive impairments. In the present article, we review findings from our laboratory and others combined with supporting literary evidences on molecular switches of brain aging and their potential as recovery targets. PMID:27114845

  18. Results of the radiological survey at State Route 17 Becker Avenue, Maywood, New Jersey (MJ033)

    SciTech Connect

    Foley, R.D.; Carrier, R.F.

    1990-03-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. 5 refs., 2 figs., 3 tabs.

  19. Step-by-Step Activities to Accompany The Dale Avenue Performance Objectives Model.

    ERIC Educational Resources Information Center

    Schenberg, Rhoda; And Others

    This kit contains performance objectives (stated in behavioral terms) for several areas of school-related skills and suggested activities and materials for teaching those skills to young children. The areas included are: (1) listening, (2) naming, (3) observing, (4) speaking, (5) writing and motor skills, (6) perceptual motor skills, (7)…

  20. Dale Avenue School Early Childhood Education Center Project. Research Bulletin Volume III, No. 2, June 1973.

    ERIC Educational Resources Information Center

    Paterson Board of Education, NJ.

    Reported are results of an evaluation of the handwriting skills of first, second, and third level students who were part of an urban early childhood education project for culturally disadvantaged children in Paterson, New Jersey. Provided is a summary of A. Gesell and F. Ilg's recommendations for handwriting instruction for kindergarten through…

  1. DOE ZERH Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning production home in the cold climate that got a HERS 38 without PV, with staggered 2x4 studs every 8”on a 2x6 plate with dense-packed R-25 cellulose, basement with 3” XPS exterior and 2: XPS under slab; a vented attic with spray foam top plates and R-60 blown cellulose; 96% AFUE furnace, 14 SEER AC, plus fresh air intake.

  2. Oxytocin enables novelty seeking and creative performance through upregulated approach: evidence and avenues for future research.

    PubMed

    De Dreu, Carsten K W; Baas, Matthijs; Boot, Nathalie C

    2015-01-01

    Oxytocin is an evolutionary ancient hypothalamic neuropeptide well known for its role in reproduction, social bonding, and group affiliation. Recent work has linked oxytocin in humans to creative cognition--the ability to produce insights, ideas, and problem solutions that are original and potentially useful. Here we review this literature, focusing on the relationship between (1) single-nucleotide polymorphisms in the oxytocin receptor (OXTR) gene; endogenous oxytocin from blood plasma, and intranasal administration of oxytocin (vs placebo), and (2) creativity-related traits (e.g., novelty seeking, extraversion, and openness to experience), and behaviors (e.g., exploration, divergent thinking, original ideation, and problem solving). Findings are interpreted in the context of the dual pathway to creativity model and except for OXTR: (1) reveal a weak to moderate but consistent association between oxytocin and creativity, which emerges because (2) oxytocin enables the cognitive flexibility pathway more than persistent information processing. Findings can be best understood in terms of oxytocin's putative effects on dopaminergic activity and concomitant approach tendency.

  3. Avenues of international cooperation in power plants life assessment and management

    SciTech Connect

    Isreb, M.

    1999-11-01

    The present paper examines various attributes, sources of funding and areas of international cooperation in power plants life assessment and management. The attributes discussed in the paper are themes, strategies, benefits and mechanism. Next, the paper focuses on the Australian-American cooperation and sources of funding. In this regard, the paper concentrates on major funding organizations from Australia and the United States such as the Australian Department of Employment, Education, Training and Youth Affairs (DEETYA), the Australian Department of Industry, Science and Tourism (DIST) and the American National Science Foundation (NSF). Finally, the paper presents the area of cooperation in line with the major thrust of the Australian power industry. The paper examines possible subject areas of international cooperation, in relation to efficiency, diversification of fuels and thermal and environmental aspects.

  4. Pseudospectral sampling of Gaussian basis sets as a new avenue to high-dimensional quantum dynamics

    NASA Astrophysics Data System (ADS)

    Heaps, Charles

    This thesis presents a novel approach to modeling quantum molecular dynamics (QMD). Theoretical approaches to QMD are essential to understanding and predicting chemical reactivity and spectroscopy. We implement a method based on a trajectory-guided basis set. In this case, the nuclei are propagated in time using classical mechanics. Each nuclear configuration corresponds to a basis function in the quantum mechanical expansion. Using the time-dependent configurations as a basis set, we are able to evolve in time using relatively little information at each time step. We use a basis set of moving frozen (time-independent width) Gaussian functions that are well-known to provide a simple and efficient basis set for nuclear dynamics. We introduce a new perspective to trajectory-guided Gaussian basis sets based on existing numerical methods. The distinction is based on the Galerkin and collocation methods. In the former, the basis set is tested using basis functions, projecting the solution onto the functional space of the problem and requiring integration over all space. In the collocation method, the Dirac delta function tests the basis set, projecting the solution onto discrete points in space. This effectively reduces the integral evaluation to function evaluation, a fundamental characteristic of pseudospectral methods. We adopt this idea for independent trajectory-guided Gaussian basis functions. We investigate a series of anharmonic vibrational models describing dynamics in up to six dimensions. The pseudospectral sampling is found to be as accurate as full integral evaluation, while the former method is fully general and integration is only possible on very particular model potential energy surfaces. Nonadiabatic dynamics are also investigated in models of photodissociation and collinear triatomic vibronic coupling. Using Ehrenfest trajectories to guide the basis set on multiple surfaces, we observe convergence to exact results using hundreds of basis functions. The pseudospectral sampling of Gaussian basis functions introduces a new and efficient means of calculating the underlying quantum mechanics associated with trajectory-guided basis sets. We also discuss the conceptual connections to the quantum trajectory method and the benefits of solving quantum mechanics on a discrete grid. We include a chapter studying the strengths and weaknesses of the parametric two-electron reduced-density-matrix (p2-RDM) method for systems susceptible to delocalization error. Density matrix methods are known to overestimate the energetic effects of electron delocalization, including severe effects such as diatomic dissociation to fractionally charged atoms. We consider the role of delocalization error in p2-RDM and demonstrate that the p2-RDM is resistant to delocalization error in challenging cases.

  5. Carbohydrate-based species recognition in sea urchin fertilization: another avenue for speciation?

    PubMed

    Biermann, Christiane H; Marks, Jessica A; Vilela-Silva, Ana-Cristina E S; Castro, Michelle O; Mourão, Paulo A S

    2004-01-01

    Spawning marine invertebrates are excellent models for studying fertilization and reproductive isolating mechanisms. To identify variation in the major steps in sea urchin gamete recognition, we studied sperm activation in three closely related sympatric Strongylocentrotus species. Sperm undergo acrosomal exocytosis upon contact with sulfated polysaccharides in the egg-jelly coat. This acrosome reaction exposes the protein bindin and is therefore a precondition for sperm binding to the egg. We found that sulfated carbohydrates from egg jelly induce the acrosome reaction species specifically in S. droebachiensis and S. pallidus. There appear to be no other significant barriers to interspecific fertilization between these two species. Other species pairs in the same genus acrosome react nonspecifically to egg jelly but exhibit species-specific sperm binding. We thus show that different cell-cell communication systems mediate mate recognition among very closely related species. By comparing sperm reactions to egg-jelly compounds from different species and genera, we identify the major structural feature of the polysaccharides required for the specific recognition by sperm: the position of the glycosidic bond of the sulfated alpha-L-fucans. We present here one of the few examples of highly specific pure-carbohydrate signal transduction. In this system, a structural change in a polysaccharide has far-reaching ecological and evolutionary consequences.

  6. Japan Fulbright Memorial Fund Program Opens New Avenues for Effective Technology Integration into Education

    NASA Astrophysics Data System (ADS)

    Paoletti, Franco; Carlucci, Lisa Marie

    2006-04-01

    Technology is increasingly playing a major role in today's education often integrated into instruction to become one of the teacher's most effective and often indispensable tools used in the classroom. It can be said that the use of technology at the beginning of this new millennium is affecting the instructional process and it is changing some of its basic connotations. The presented work analyzes the impact of various technologies on education emphasizing the advantages provided by a successful integration, the obstacles encountered along the way, and the methodologies currently used in the process. ``Educational exchange can turn nations into people, contributing as no other form of communication can to the humanizing of international relations'' (Senator J.M. Fulbright). Technology of this modern era is providing the indispensable tool to achieve this superior level of communication overcoming historical, cultural, and language barriers. In the context of the Japan Fulbright Memorial Fund (JFMF) Teacher Program, we analyze the impact of technology on educational cross-cultural exchanges to raise awareness and interest of the scientific/educational community on the need of establishing stronger international relations promoting world peace and global prosperity.

  7. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues

    PubMed Central

    Obulesu, M; Rao, Dowlathabad Muralidhara

    2011-01-01

    Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms. These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtisufolia (Sicklepod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), and Salvia officinalis (Garden sage, common sage). PMID:21716802

  8. Pointing the Way: Possible Avenues of Development in the Field of Mathematics Education

    ERIC Educational Resources Information Center

    Ross, Vicki

    2005-01-01

    An essay review of "Assessing Children's Mathematical Knowledge: Social Class, Sex and Problem Solving" by Barry Cooper and Mirad Dunne, Philadelphia: Open University Press, 2000; "Talking Mathematics in School: Studies in Teaching and Learning," Ed. Magdalene Lampert and Merrie L. Blunk, New York: Teachers College Press, 1998; "Reconstructing…

  9. Grassland-Cropping Rotations: An Avenue for Agricultural Diversification to Reconcile High Production with Environmental Quality.

    PubMed

    Lemaire, Gilles; Gastal, François; Franzluebbers, Alan; Chabbi, Abad

    2015-11-01

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity at all levels of organization, i.e., field, farm, landscape, and region. Therefore, we postulate that negative environmental impacts of modern agriculture are due more to production simplification than to inherent characteristics of agricultural productivity. Thus by enhancing diversity within agricultural systems, it should be possible to reconcile high quantity and quality of food production with environmental quality. Intensification of livestock and cropping systems separately within different specialized regions inevitably leads to unacceptable environmental impacts because of the overly uniform land use system in intensive cereal areas and excessive N-P loads in intensive animal areas. The capacity of grassland ecosystems to couple C and N cycles through microbial-soil-plant interactions as a way for mitigating the environmental impacts of intensive arable cropping system was analyzed in different management options: grazing, cutting, and ley duration, in order to minimize trade-offs between production and the environment. We suggest that integrated crop-livestock systems are an appropriate strategy to enhance diversity. Sod-based rotations can temporally and spatially capture the benefits of leys for minimizing environmental impacts, while still maintaining periods and areas of intensive cropping. Long-term experimental results illustrate the potential of such systems to sequester C in soil and to reduce and control N emissions to the atmosphere and hydrosphere. PMID:26070897

  10. Radiological re-survey results at 146 West Central Avenue, Maywood, New Jersey (MJ034)

    SciTech Connect

    Murray, M.E.; Johnson, C.A.

    1994-05-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from 1916 to 1959. During the early years of operation, MCW stored wastes and residues in low-lying areas west of the processing facilities and consequently some of the residuals containing radioactive materials migrated offsite to the surrounding area. Subsequently, the U.S. Department of Energy (DOE) designated for remedial action the old MCW property and several vicinity properties. Additionally, in 1984, the property at 146 West Central Ave., Maywood, New Jersey and properties in its vicinity were included as a decontamination research and development project under the DOE Formerly Utilized Sites Remedial Action Program. In 1987 and 1988, at the request of DOE, Oak Ridge National Laboratory (ORNL) conducted a radiological survey on this property. A report describing this survey was published in 1989. A second radiological survey by ORNL was conducted on this property in May 1993 at the request of DOE after an ad hoc radiological survey, requested by the property owner and conducted by Bechtel National, Inc. (BNI), identified some contamination not previously found by ORNL. The purpose of the second ORNL survey was to determine whether radioactive materials from the old MCW were present on the property, and if so, if radioactive materials present were above guidelines. A certified civil survey was requisitioned by ORNL to determine actual property boundaries before beginning the radiological re-survey. The re-survey included a surface gamma scan and the collection of a large number of soil samples for radionuclide analyses. Results of this survey demonstrated that although elevated residual thorium-232 contamination was present in a few isolated spots on the southern end of the backyard, it did not exceed DOE guidelines.

  11. The applicability of OSL as a sedimentological proxy: new avenues to distinguish extreme events

    NASA Astrophysics Data System (ADS)

    Lopez, G. I.

    2012-12-01

    Signature underwater tsunami deposits have been relatively recently found in the upper Mediterranean shelf offshore Israel. They have been attributed as a potential cause for the demise of the ancient Roman city of Caesarea Maritima and its artificial Herodian harbour of Sebastos. Present annual large winter storm activity (2010-2011; waves heights up to 14 m) has severely impacted the area, showing increased coastal erosion and rigorous movement of nearshore sands, complicating the stratigraphical histories of the near offshore record. Recent sedimentological and geoarchaeological studies conducted in and around the harbour have been aimed to investigate extreme event characterization by different means, using Optically Stimulated Luminescence (OSL). A comparative study of modern and palaeo-storm sediments was launched in order to obtain physical correlation between offshore sediments, enabling further comparison with historical tsunami deposits, as well as modern and ancient sands emplaced during normal marine conditions. A suite of previously collected and identified sediment samples was selected from the same area where the modern storm analogues were collected. The palaeo-samples came from long-vertical hydraulic percussion cores (14-30 m depths) and small horizontal tubes pushed into excavated underwater sediment walls (2-12 m depths). The uniqueness of OSL relays on its capacity to date the last time a mineral grain was effectively exposed to sunlight, just prior to its burial. It is intrinsically related to final depositional process, which should reflect the completeness of the OSL signal resetting (zeroing process), evidenced by the normality and modality of the Equivalent Dose (DE) distribution. In Optical Dating, DE over-dispersion values have been used as a measure of inhomogeneitiy in the natural palaeo-dose of sediments. Such heterogeneity can be due to an array of causes, including insufficient zeroing during transport and deposition, or turbation processes after burial. Environments where sediments are well exposed to daylight at deposition (e.g. aeolian and some coastal) do not show extreme over-dispersion values but rather well clustered DE's as noted by probability-distribution plots. The degrees of variance and skewness of Gaussian or relative-probability distributions are intrinsically related to the scatter factor. Hence, the latter could be used to differentiate between depositional mechanisms and/or environmental settings. In this study, the single-aliquot regenerative-dose (SAR) protocol was used to measure the OSL signals from single grains of quartz from tsunami, storm and normal marine conditions deposits. Over-dispersion analyses were conducted on all samples. Preliminary results suggest the possibility of differentiating between all three types of deposits based on pre-established over-dispersion values and representative single-dose population distributions. Further comparative OSL experiments are currently being carried out on other known tsunamigenic analogues to further evaluate OSL signal behaviours and constrain the findings (2011 Tohoku Tsunami; 1979 night Petatlán Tsunami). Rather than a dating tool, OSL was used to identify signal patterns exclusive to known depositional conditions, in hope of applying it as sedimentological proxy in event stratigraphy and palaeoseismic tsunami research.

  12. Participation in Field Learning and Teaching Opportunities: Avenues to Research and Publication

    ERIC Educational Resources Information Center

    Albert, Donald; Strait, John; Fujimoto-Strait, Ava

    2016-01-01

    Field experiences continue to be a hallmark of a geographer's education and, for that matter, reeducation, as we all strive to remain current in the real world. Academic geographers beginning their ascent towards tenure and promotion might consider augmenting their portfolios with materials emerging from field teaching and learning activities.

  13. Probabilistic inversion in the context of EM studies: Where we are and avenues for the future

    NASA Astrophysics Data System (ADS)

    Linde, Niklas; Rosas-Carbajal, Marina

    2016-04-01

    Modern Markov chain Monte Carlo (MCMC) algorithms can explore the posterior distribution of highly non-linear inverse problems in moderately high dimensions. For instance, 2-D magnetotelluric inversion is feasible for several hundreds of independent model parameters. At present, 3-D applications are limited to a few tenths of model parameters, but even such low dimensions make MCMC useful in time-lapse inversions when using appropriate model parameterizations. It is straightforward to invert for the noise level of the data (i.e., hierarchical Bayes) and the appropriate strength of the prior constraints (i.e., empirical Bayes). It is even possible to consider the dimension of the problem as an unknown (i.e., reversible-jump or transdimensional inversion). Nevertheless, persistent problems that plague MCMC inversions in geophysics include the choice of the prior probability density function, overly simplistic descriptions of data and modeling errors in the likelihood function, as well as truncation errors or spectral leakage that are inevitable when describing the Earth by a finite number of parameters. This leads to uncertainty estimates that often are overly optimistic (or alternatively limited by a too restrictive set of hypotheses) and final results that at times are only vaguely more informative than those obtained by classical Occam inversions. We argue that formal model selection, multiple-point statistics and approximate Bayesian computation may offer solutions to overcome some of these outstanding issues.

  14. The Madison Avenue Effect: How drug presentation style influences adherence and outcome in patients with asthma

    PubMed Central

    Clerisme-Beaty, Emmanuelle M; Bartlett, Susan J; Teague, W. Gerald; Lima, John; Irvin, Charles G; Cohen, Rubin; Castro, Mario; Wise, Robert A; Rand, Cynthia S

    2010-01-01

    Background Little is known about how drug presentation influences medication adherence. Objective Examine the effect of an educational program aimed at increasing expectations of treatment benefit on medication adherence. Methods Data are analyzed from 99 participants who underwent electronic drug monitoring during TAPE (Trial of Asthma Patient Education), a randomized placebo-controlled multi-center trial. Participants with suboptimally-controlled asthma were randomized to placebo or montelukast in conjunction with a presentation mode that was either neutral or designed to increase outcome expectancy. Adherence was monitored electronically over 4 weeks, and was defined as ≥ 80% use of prescribed doses. Outcome expectancy, peak expiratory flow, pre-bronchodilator forced expiratory volume, asthma control (ACQ), and asthma-related quality of life were assessed at baseline and at the 4-week follow-up. Results Average electronic medication adherence was 69.9%. There was a significant interaction between presentation mode and drug assignment, with participants in the enhanced/montelukast group having a higher change in outcome expectancy (Δ 2.1 points, p < 0.001) and better medication adherence (odds ratio 4.0, CI 1.1, 14.3) compared to those in the neutral/placebo group. There was no difference in asthma symptoms, quality of life, or clinical outcomes based on presentation mode. Rather, increased outcome expectancy was associated with modest improvements in asthma symptoms after adjusting for presentation mode, drug assignment, and medication adherence. Conclusion The use of an enhanced presentation aimed at increasing outcome expectancy may lead to improved medication adherence. PMID:21281871

  15. Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier.

    PubMed

    Villa, Carlos H; Pan, Daniel C; Zaitsev, Sergei; Cines, Douglas B; Siegel, Donald L; Muzykantov, Vladimir R

    2015-07-01

    For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics, biodistribution, controlled release and pharmacodynamics. Approaches include encapsulation of drugs within erythrocytes, as well as coupling of drugs onto the red cell surface. This review focuses on the latter approach, and examines the delivery of red blood cell (RBC)-surface-bound anti-inflammatory, anti-thrombotic and anti-microbial agents, as well as RBC carriage of nanoparticles. Herein, we discuss the progress that has been made in surface loading approaches, and address in depth the issues relevant to surface loading of RBC, including intrinsic features of erythrocyte membranes, immune considerations, potential surface targets and techniques for the production of affinity ligands.

  16. Implementing and Simulating Dynamic Traffic Assignment with Intelligent Transportation Systems in Cube Avenue

    NASA Technical Reports Server (NTRS)

    Foytik, Peter; Robinson, Mike

    2010-01-01

    As urban populations and traffic congestion levels increase, effective use of information and communication tools and intelligent transportation systems as becoming increasingly important in order to maximize the efficiency of transportation networks. The appropriate placement and employment of these tools within a network is critical to their effectiveness. This presentation proposes and demonstrates the use of a commercial transportation simulation tool to simulate dynamic traffic assignment and rerouting to model route modifications as a result of traffic information.

  17. 78 FR 11142 - Connor Hayden Kraegel, 19917 Spurrier Avenue, Poolesville, MD 20837; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... and willfully exporting from the United States a set of AN/AVS-6 night vision goggles, which is... successive Presidential Notices, the most recent being that of August 15, 2012 (77 FR 49699 (August 16,...

  18. The unexplored avenues of human skin: electromagnetic properties in the sub-THz band

    NASA Astrophysics Data System (ADS)

    Feldman, Y.; Safrai, E.; Ben Ishai, P.; Puzenko, A.; Agranat, A. J.; Caduff, A.

    2012-03-01

    Recent studies of the minute morphology of the skin by optical coherence tomography showed that the sweat ducts in human skin become helically shaped tubes in the Epidermis and are filled with an aqueous solution. When considered as entities embedded in a dielectric media, they resemble helical antennas. The spectral response obtained by our computer simulations coincides with the analytical prediction of antenna theory and support this hypothesis, if a fast enough current mechanism exists in the duct. In particular the strongest spectral response of the simulation was noted around the predicted frequencies (240 GHz and 380 GHz) for the respective normal and axial modes of the helical structure. Furthermore, circular dichroism of the reflected electromagnetic field is a characteristic property of such helical antennas and it was shown that it is indeed a characteristic of the simulation model. Fast proton hopping is posited as the current mechanism. Consequently experimental evidence is presented that the spectral response of the skin in the sub-Terahertz region is governed by the level of activity of the perspiration system. This in turn is moderated by the Sympathetic Nerve Response and is demonstrated by the correlation to physiological stress as manifested by the pulse rate and the systolic blood pressure. These physical relaxations are tonic in nature (lasting more than a minute). Could the phasic characteristic of emotional excitation also be evident in the reflection coefficient? By applying techniques borrowed from psychiatric science we hope to answer this point in our paper.

  19. Bioinformatics goes to school--new avenues for teaching contemporary biology.

    PubMed

    Wood, Louisa; Gebhardt, Philipp

    2013-01-01

    Since 2010, the European Molecular Biology Laboratory's (EMBL) Heidelberg laboratory and the European Bioinformatics Institute (EMBL-EBI) have jointly run bioinformatics training courses developed specifically for secondary school science teachers within Europe and EMBL member states. These courses focus on introducing bioinformatics, databases, and data-intensive biology, allowing participants to explore resources and providing classroom-ready materials to support them in sharing this new knowledge with their students. In this article, we chart our progress made in creating and running three bioinformatics training courses, including how the course resources are received by participants and how these, and bioinformatics in general, are subsequently used in the classroom. We assess the strengths and challenges of our approach, and share what we have learned through our interactions with European science teachers.

  20. Technical and Vocational Education in Cameroon and Critical Avenues for Development

    ERIC Educational Resources Information Center

    Che, S. Megan

    2007-01-01

    Technical and vocational education (TVE) can influence development and economic progress for post-colonial societies. Some newly independent sub-Saharan African countries attempted curricular transformation that might produce a skilled workforce through widespread access to versions of TVE. In Cameroon, no such post-colonial curricular revolution…

  1. Grassland-Cropping Rotations: An Avenue for Agricultural Diversification to Reconcile High Production with Environmental Quality.

    PubMed

    Lemaire, Gilles; Gastal, François; Franzluebbers, Alan; Chabbi, Abad

    2015-11-01

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity at all levels of organization, i.e., field, farm, landscape, and region. Therefore, we postulate that negative environmental impacts of modern agriculture are due more to production simplification than to inherent characteristics of agricultural productivity. Thus by enhancing diversity within agricultural systems, it should be possible to reconcile high quantity and quality of food production with environmental quality. Intensification of livestock and cropping systems separately within different specialized regions inevitably leads to unacceptable environmental impacts because of the overly uniform land use system in intensive cereal areas and excessive N-P loads in intensive animal areas. The capacity of grassland ecosystems to couple C and N cycles through microbial-soil-plant interactions as a way for mitigating the environmental impacts of intensive arable cropping system was analyzed in different management options: grazing, cutting, and ley duration, in order to minimize trade-offs between production and the environment. We suggest that integrated crop-livestock systems are an appropriate strategy to enhance diversity. Sod-based rotations can temporally and spatially capture the benefits of leys for minimizing environmental impacts, while still maintaining periods and areas of intensive cropping. Long-term experimental results illustrate the potential of such systems to sequester C in soil and to reduce and control N emissions to the atmosphere and hydrosphere.

  2. Collision-Induced Spectra: AN Avenue to Investigate Microscopic-Scale Diffusion in Fluids

    NASA Astrophysics Data System (ADS)

    Herrebout, Wouter A.; van der Veken, Benjamin J.; Kouzov, Alexander

    2014-06-01

    New data on the IR spectra induced by intermolecular interactions in liquid cryogenic mixtures at T=89 K (O2 in LAr and LN2 and binary O2-Ar solutions in LN2) are reported. The induced fundamental bands appear as diffuse pedestals (with FWHH≈100 cm-1) on which weak, paradoxically sharp lines (FWHH≈2 cm-1) develop at the 2326 and 1552 cm-1 frequencies of the free-molecule vibrational transitions in N2 and O2, respectively. In LAr and LN2 these lines were carefully separated and studied at varied O2 concentrations up to c=0.23 mole fractions (mf). While the 1552 cm-1 line scales as c[O2]2 and thus is induced by the O2-O2 interactions in a bulk of cryosolvent (Ar, N2), the 2326 cm-1 feature varies linearly with c[O2] and hence is caused by interaction of a guest (O2) with a vibrating host (N_2). The impurity induction mechanism was further supported by our data on the binary O2-Ar solutions in LN2 %for which the spectra were recorded at the fixed c[O2] (0.03 and 0.06 mf) and the varied c% [Ar]≤0.2 mf. Both series revealed the same (linear) enhancement of the sharp N2 line by argon, in an accord with our previous studies of the Ar-LN2 system. The results suggest that the resonance 2326 cm-1 feature is primarily due to the local distortion of the first coordination sphere around a vibrating N_2 by a guest molecule. We also notice that the resonance lines should be due to the dispersion- and overlap-induced dipole moments independent on the rotational degrees of freedom. As our previous studies of the H2-LNe system showed, the unusual line sharpness is a conspicuous manifestation of the relative solvent-solute and solute-solute translations dramatically retarded in a liquid by a fast velocity relaxation, an effect directly related to the microscopic-scale diffusion. The collision-induced spectra thus open up new vistas for studies of microscopic liquid dynamics. W.A. Herrebout, A.A. Stolov, E.J. Sluyts, and B.J. van der Veken, Chem. Phys. Lett. 295, 223 (1998) J.E. Bohr and K.L.C. Hunt, J. Chem. Phys. 86, 5441 (1987) W. A. Herrebout, B. J. van der Veken, and A. P. Kouzov, Phys.Rev. Lett. 101, 093001 (2008) W. A. Herrebout, B. J. van der Veken, and A. P. Kouzov, J. Chem. Phys. 137, 084509 (2012)

  3. The musical Stroop effect. Opening a new avenue to research on automatisms.

    PubMed

    Grégoire, Laurent; Perruchet, Pierre; Poulin-Charronnat, Bénédicte

    2013-01-01

    The usual color-word Stroop task, as well as most other Stroop-like paradigms, has provided invaluable information on the automaticity of word reading. However, investigating automaticity through reading alone has inherent limitations. This study explored whether a Stroop-like effect could be obtained by replacing word reading with note naming in musicians. Note naming shares with word reading the crucial advantage of being intensively practiced over years by musicians, hence allowing to investigate levels of automatism that are out of reach of laboratory settings. But the situation provides much greater flexibility in manipulating practice. For instance, even though training in musical notation is often conducted in parallel with the acquisition of literacy skills during childhood, many exceptions make that it can be easily decoupled from age. Supporting the possibility of exploiting note naming as a new tool for investigating automatisms, musicians asked to process note names written inside note pictures in incongruent positions on a staff were significantly slowed down in both a go/no-go task (Experiment 1) and a verbal task (Experiment 2) with regard to a condition in which note names were printed inside note pictures in congruent positions. PMID:23548983

  4. The Role of Monocytes in Ischemic Stroke Pathobiology: New Avenues to Explore.

    PubMed

    ElAli, Ayman; Jean LeBlanc, Noëmie

    2016-01-01

    Ischemic stroke accounts for the majority of stroke cases and constitutes a major cause of death and disability in the industrialized world. Inflammation has been reported to constitute a major component of ischemic stroke pathobiology. In the acute phase of ischemic stroke, microglia, the resident macrophages of the brain, are activated, followed by several infiltration waves of different circulating immune cells into the brain. Among these circulating immune cells, monocytes have been shown to play a particularly important role. Following their infiltration, monocytes differentiate into potent phagocytic cells, the monocyte-derived macrophages (MDMs), in the ischemic brain. Initially, the presence of these cells was considered as marker of an exacerbated inflammatory response that contributes to brain damage. However, the recent reports are suggesting a more complex and multiphasic roles of these cells in ischemic stroke pathobiology. Monocytes constitute a heterogeneous group of cells, which comprises two major subsets in rodent and three major subsets in human. In both species, two equivalent subsets exist, the pro-inflammatory subset and the anti-inflammatory subset. Recent data have demonstrated that ischemic stroke differentially regulate monocyte subsets, which directly affect ischemic stroke pathobiology and may have direct implications in ischemic stroke therapies. Here, we review the recent findings that addressed the role of different monocyte subsets in ischemic stroke pathobiology, and the implications on therapies. PMID:26941641

  5. Exploring Symmetry as an Avenue to the Computational Design of Large Protein Domains

    SciTech Connect

    Fortenberry, Carie; Bowman, Elizabeth Anne; Proffitt, Will; Dorr, Brent; Combs, Steven; Harp, Joel; Mizoue, Laura; Meiler, Jens

    2012-03-15

    It has been demonstrated previously that symmetric, homodimeric proteins are energetically favored, which explains their abundance in nature. It has been proposed that such symmetric homodimers underwent gene duplication and fusion to evolve into protein topologies that have a symmetric arrangement of secondary structure elements - 'symmetric superfolds'. Here, the ROSETTA protein design software was used to computationally engineer a perfectly symmetric variant of imidazole glycerol phosphate synthase and its corresponding symmetric homodimer. The new protein, termed FLR, adopts the symmetric ({beta}{alpha}){sub 8} TIM-barrel superfold. The protein is soluble and monomeric and exhibits two-fold symmetry not only in the arrangement of secondary structure elements but also in sequence and at atomic detail, as verified by crystallography. When cut in half, FLR dimerizes readily to form the symmetric homodimer. The successful computational design of FLR demonstrates progress in our understanding of the underlying principles of protein stability and presents an attractive strategy for the in silico construction of larger protein domains from smaller pieces.

  6. Exploring exercise as an avenue for the treatment of anxiety disorders

    PubMed Central

    DeBoer, Lindsey B; Powers, Mark B; Utschig, Angela C; Otto, Michael W; Smits, Jasper AJ

    2012-01-01

    Anxiety disorders constitute a significant public health problem. Current gold standard treatments are limited in their effectiveness, prompting the consideration of alternative approaches. In this review, we examine the evidence for exercise as an intervention for anxiety disorders. This evidence comes from population studies, studies of nonclinical anxiety reduction, as well as a limited number of studies of clinically anxious individuals. All of these studies provide converging evidence for consistent beneficial effects of exercise on anxiety, and are consistent with a variety of accounts of the mechanism of anxiety reduction with exercise. Further study of clinical populations is encouraged, as are studies of the mechanism of change of exercise interventions, which have the potential to help refine exercise intervention strategies. Likewise, studies that identify moderators of treatment efficacy will assist clinicians in deciding how and for whom to prescribe exercise. PMID:23002943

  7. 75 FR 17139 - Proposed CERCLA Section 122(h) Cost Recovery Settlement for the Kentucky Avenue Wellfield...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... York. The Settling Party agrees to pay EPA $82,000 in reimbursement of certain response costs related to the performance of the work incurred by EPA at the Site. The settlement includes a covenant by...

  8. Osage Avenue Is Burning: The Influence of Race upon Crisis Public Relations in Philadelphia.

    ERIC Educational Resources Information Center

    Bishop, Robert L.; Boles, Wendy Gotchel

    A study examined public relations aspects of the police confrontation and bombing of the revolutionary Black group, MOVE, in Philadelphia, in which 11 persons were killed, 250 were left homeless, and 61 homes were destroyed. It explored if and how race affected the crisis and whether Black media and general media were treated differently. City…

  9. Powder-Coated Towpreg: Avenues to Near Net Shape Fabrication of High Performance Composites

    NASA Technical Reports Server (NTRS)

    Johnston, N. J.; Cano, R. J.; Marchello, J. M.; Sandusky, D. A.

    1995-01-01

    Near net shape parts were fabricated from powder-coated preforms. Key issues including powder loss during weaving and tow/tow friction during braiding were addressed, respectively, by fusing the powder to the fiber prior to weaving and applying a water-based gel to the towpreg prior to braiding. A 4:1 debulking of a complex 3-D woven powder-coated preform was achieved in a single step utilizing expansion rubber molding. Also, a process was developed for using powder-coated towpreg to fabricate consolidated ribbon having good dimensional integrity and low voids. Such ribbon will be required for in situ fabrication of structural components via heated head advanced tow placement. To implement process control and ensure high quality ribbon, the ribbonizer heat transfer and pulling force were modeled from fundamental principles. Most of the new ribbons were fabricated from dry polyarylene ether and polymide powders.

  10. Composite Avenue beyond the Standard Model ---Legacy of Sakata in LHC Era---

    NASA Astrophysics Data System (ADS)

    Yamawaki, K.

    Higgs boson may be a composite particle as Sakata vigorously looked for never-ending substructures of Nature. He proposed the Sakata model for hadrons, which was the prototype of the quark model and thus lauched the last Revolution in particle physics continued all the way up to Kabayashi-Maskawa work which completed the Standard Model today. Inspired by Sakata's spirit we shall discuss composite Higgs boson in various models of our own for the dynamical symmetry breaking with large anomalous dimension: The techni-dilaton in the walking technicolor (WTC) with gamma_m ≃ 1, the bar t t composite (``top-Higgs'') in the top-quark condensate model with gamma_m ≃ 2, and their variants in the models with 1 < gamma_m < 2 (strong ETC Technicolor, etc.). Among others we will focus on WTC which has an approximate scale symmetry in the region relevant to the dynamical mass generation. Such a conformal gauge dynamics is characterized by the essential singularity scaling, breakdown of the Ginzburg-Landau/Gell-Mann-Levy effective theory, and also by a large anomalous dimension gamma_m = 1. In contrast to the folklore that Technicolor is a ``Higgsless theory'', there exists a composite Higgs, techni-dilaton, in the WTC as a composite pseudo Nambu-Goldstone boson associated with the spontaneously broken (approximate) scale symmetry, with its mass only arising from the (nonperturbative) scale anomaly and hence being much smaller than those of other techni-hadrons. The techni-dilaton has a mass typically of order 500-600 GeV and can be discovered at LHC. We shall also touch upon the endeavor to discover WTC on the lattice.

  11. Oxytocin enables novelty seeking and creative performance through upregulated approach: evidence and avenues for future research.

    PubMed

    De Dreu, Carsten K W; Baas, Matthijs; Boot, Nathalie C

    2015-01-01

    Oxytocin is an evolutionary ancient hypothalamic neuropeptide well known for its role in reproduction, social bonding, and group affiliation. Recent work has linked oxytocin in humans to creative cognition--the ability to produce insights, ideas, and problem solutions that are original and potentially useful. Here we review this literature, focusing on the relationship between (1) single-nucleotide polymorphisms in the oxytocin receptor (OXTR) gene; endogenous oxytocin from blood plasma, and intranasal administration of oxytocin (vs placebo), and (2) creativity-related traits (e.g., novelty seeking, extraversion, and openness to experience), and behaviors (e.g., exploration, divergent thinking, original ideation, and problem solving). Findings are interpreted in the context of the dual pathway to creativity model and except for OXTR: (1) reveal a weak to moderate but consistent association between oxytocin and creativity, which emerges because (2) oxytocin enables the cognitive flexibility pathway more than persistent information processing. Findings can be best understood in terms of oxytocin's putative effects on dopaminergic activity and concomitant approach tendency. PMID:26267407

  12. Luminescence dating of interglacial coastal depositional systems: Recent developments and future avenues of research

    NASA Astrophysics Data System (ADS)

    Lamothe, Michel

    2016-08-01

    Luminescence dating offers new opportunities to explore the evolution of Quaternary marine coastal facies and landforms. This review highlights the main advances in luminescence geochronology of interglacial coastal sediments through the analysis of 547 luminescence ages, most of which were published during the last decade. The majority of these reported luminescence investigations have been carried out along passive margin coasts. Since the turn of the century, the discovery of a normalization procedure known as Single Aliquot Regeneration (SAR) has drastically reduced data scatter and improved precision, with the consequence that quartz SAR optically-stimulated luminescence OSL has become the dating protocol of choice for the Last Interglacial (LIG) period. A more complex technique, known as thermally-transferred OSL (TT-OSL), is presumably proposed for dating older interglacials of the Mid-Pleistocene and beyond. Feldspar luminescence is increasingly being applied to dating Pleistocene sea level high stands due to a much higher dose saturation level than quartz OSL. The use of feldspar IRSL (Infrared-stimulated luminescence) is limited by the occurrence of variable, but ubiquitous anomalous fading (AF). Following the advent of AF-correction methods, several Middle Pleistocene sites have been amenable to dating, albeit with significant related uncertainties. Recently, new protocols involving the measurement of post-IR IRSL at elevated temperatures have yielded relatively coherent ages for interglacial sediments up to ca. 300 ka. Quartz OSL/TT-OSL, AF-corrected IRSL, and post-IR IRSL ages are generally correlated with periods of sea level high stands. A few ages are reported from the early and middle part of the Middle Pleistocene, as MIS11, 9 and more commonly MIS7 high stands are documented in strongly uplifting active margin coasts. However, by far the most obvious age peak corresponds to the end of the LIG. The MIS5e shoreline is probably the most studied and luminescence-dated coastal feature of all, as the chronology of the sea level markers is crucial to assess global eustatic sea level variations through the course of the last interglacial. Nevertheless, the observed abundance of young (100-120 ka) luminescence ages for presumed MIS5e sediments may underline methodological issues, and/or reflect the higher preservation potential of late regressive sequences. On the other hand, the occurrence of geographically distant reports of MIS5a high stand might reflect a true eustatic origin for this event. Age analysis supports the impression of general reliability of luminescence for the timing of former sea level high stands. There is a clear need to address issues in dose rate variability, in the phenomenology of fading in feldspar, and in the behaviour of luminescence growth with dose, both in laboratory and natural conditions. These could be addressed and properly evaluated by dating different minerals, as multiple or single grains, with consequent variable internal dose rates. More robust practices in the application of luminescence dating techniques could eventually constrain the age uncertainties to no better than 2-3%. Therefore, the strength of luminescence as a dating tool is more in terms of its extended age range and the ubiquity of datable material.

  13. Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease.

    PubMed

    Zorzi, Francesca; Calabrese, Emma; Monteleone, Giovanni

    2015-12-01

    In Crohn's disease, one of the two major forms of inflammatory bowel diseases in human beings, persistent and chronic inflammation promotes fibrotic processes thereby facilitating formation of strictures, the most common indication for surgical intervention in this disorder. The pathogenesis of Crohn's disease-associated fibrosis is not fully understood, but variants of genes involved in the recognition of microbial components/products [e.g. CARD15 (caspase-activating recruitment domain 15) and ATG16L1 (autophagy-related 16-like 1)] are associated with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional alterations of cells involved in the fibrogenic process, as well as molecules that stimulate such cells to produce elevated amounts of collagen and other ECM-related proteins. In the present review, we assess the current knowledge about cellular and molecular mediators of intestinal fibrosis and describe results of recent studies aimed at testing the preventive/therapeutic effect of compounds in experimental models of intestinal fibrosis.

  14. Basic Advances and New Avenues in Therapy of Spinal Cord Injury

    PubMed Central

    Dobkin, Bruce H.; Havton, Leif A.

    2014-01-01

    The prospects for successful clinical trials of neuroprotective and neurorestorative interventions for patients with acute and chronic myelopathies depend on preclinical animal models of injury and repair that reflect the human condition. Remarkable progress continues in the attempt to promote connections between the brain and the sensory and motor neurons below a spinal cord lesion. Recent experiments demonstrate the potential for biological therapies to regenerate or remyelinate axons and to incorporate new neural cells into the milieu of a traumatic spinal cord injury. The computational flexibility and plasticity of the sensorimotor systems of the brain, spinal cord, and motor unit make functional use of new circuitry feasible in patients. To incorporate residual and new pathways, neural repair strategies must be coupled to rehabilitation therapies that drive activity-dependent plasticity for walking, for reaching and grasping, and for bowel and bladder control. Prevention of pain and dysautonomia are also clinical targets. Research aims to define the temporal windows of opportunity for interventions, test the safety and efficacy of delivery systems of agents and cells, and provide a better understanding of the cascades of gene expression and cell interactions both acutely and chronically after injury. These bench-to-bedside studies are defining the neurobiology of spinal cord injury rehabilitation. PMID:14746521

  15. Avenues for Scientist Involvement in Earth and Space Science Education and Public Outreach (Invited)

    NASA Astrophysics Data System (ADS)

    Peticolas, L. M.; Gross, N. A.; Hsu, B. C.; Shipp, S. S.; Buxner, S.; Schwerin, T. G.; Smith, D.; Meinke, B. K.

    2013-12-01

    NASA's Science Mission Directorate (SMD) Science Education and Public Outreach (E/PO) Forums are charged with engaging, extending, supporting, and coordinating the community of E/PO professionals and scientists involved in Earth and space science education activities. This work is undertaken to maximize the effectiveness and efficiency of the overall national NASA science education and outreach effort made up of individual efforts run by these education professionals. This includes facilitating scientist engagement in education and outreach. A number of resources and opportunities for involvement are available for scientists involved in - or interested in being involved in - education or outreach. The Forums provide opportunities for earth and space scientists to stay informed, communicate, collaborate, leverage existing programs and partnerships, and become more skilled education practitioners. Interested scientists can receive newsletters, participate in monthly calls, interact through an online community workspace, and attend E/PO strategic meetings. The Forums also provide professional development opportunities on a myriad of topics, from common pre-conceptions in science, to program evaluation, to delivering effective workshops. Thematic approaches, such as Earth Science Week (http://www.earthsciweek.org), and the Year of the Solar System (http://solarsystem.nasa.gov/yss) are coordinated by the Forums; through these efforts resources are presented topically, in a manner that can be easily ported into diverse learning environments. Information about the needs of audiences with which scientists interact - higher education, K-12 education, informal education, and public - are provided by SMD's Audience-Based Working Groups. Their findings and recommendations are made available to inform the activities and products of E/PO providers so they are able to better serve these audiences. Also available is a 'one-stop shop' of SMD E/PO products and resources that can be used in conjunction with E/PO activities, NASA Wavelength (http://nasawavelength.org). Further supporting higher-education efforts, the Forums coordinate a network of science faculty, bringing them together at science conferences to share resources and experiences and to discuss pertinent education research. An online higher education clearinghouse, EarthSpace (http://www.lpi.usra.edu/earthspace), has been developed to provide faculty with news and funding information, the latest education research and resources for teaching undergraduates, and undergraduate course materials, including lectures, labs, and homework. This presentation will explore the Science E/PO Forums' pathways and tools available to support scientists involved in - or interested in being involved in - E/PO.

  16. Avenues for Scientist Involvement in Planetary Science Education and Public Outreach

    NASA Astrophysics Data System (ADS)

    Shipp, S. S.; Buxner, S.; Cobabe-Ammann, E. A.; Dalton, H.; Bleacher, L.; Scalice, D.

    2012-12-01

    The Planetary Science Education and Public Outreach (E/PO) Forum is charged by NASA's Science Mission Directorate (SMD) with engaging, extending, and supporting the community of E/PO professionals and scientists involved in planetary science education activities in order to help them more effectively and efficiently share NASA science with all learners. A number of resources and opportunities for involvement are available for planetary scientists involved in - or interested in being involved in - E/PO. The Forum provides opportunities for community members to stay informed, communicate, collaborate, leverage existing programs and partnerships, and become more skilled education practitioners. Interested planetary scientists can receive newsletters, participate in monthly calls, interact through an online community workspace, and attend annual E/PO community meetings and meetings of opportunity at science and education conferences. The Forum also provides professional development opportunities on a myriad of topics, from common pre-conceptions in planetary science to program evaluation, to delivering effective workshops. Thematic approaches, such as the Year of the Solar System (http://solarsystem.nasa.gov/yss), are coordinated by the Forum; through these efforts resources are presented topically, in a manner that can be easily ported into diverse learning environments. Information about the needs of audiences with which scientists interact - higher education, K-12 education, informal education, and public - currently is being researched by SMD's Audience-Based Working Groups. Their findings and recommendations will be made available to inform the activities and products of E/PO providers so they are able to better serve these audiences. Also in production is a "one-stop-shop" of SMD E/PO products and resources that can be used in conjunction with E/PO activities. Further supporting higher-education efforts, the Forum coordinates a network of planetary science faculty, bringing them together at science conferences to share resources and experiences and to discuss pertinent education research. An online higher education clearinghouse, (EarthSpace - http://www.lpi.usra.edu/earthspace), has been developed to provide faculty with news and funding information, the latest education research and resources for teaching undergraduates, and undergraduate course materials, including lectures, labs, and homework. The presentation will explore the Planetary Science E/PO Forum pathways and tools available to support scientists involved in - or interested in being involved in - E/PO.

  17. The musical Stroop effect. Opening a new avenue to research on automatisms.

    PubMed

    Grégoire, Laurent; Perruchet, Pierre; Poulin-Charronnat, Bénédicte

    2013-01-01

    The usual color-word Stroop task, as well as most other Stroop-like paradigms, has provided invaluable information on the automaticity of word reading. However, investigating automaticity through reading alone has inherent limitations. This study explored whether a Stroop-like effect could be obtained by replacing word reading with note naming in musicians. Note naming shares with word reading the crucial advantage of being intensively practiced over years by musicians, hence allowing to investigate levels of automatism that are out of reach of laboratory settings. But the situation provides much greater flexibility in manipulating practice. For instance, even though training in musical notation is often conducted in parallel with the acquisition of literacy skills during childhood, many exceptions make that it can be easily decoupled from age. Supporting the possibility of exploiting note naming as a new tool for investigating automatisms, musicians asked to process note names written inside note pictures in incongruent positions on a staff were significantly slowed down in both a go/no-go task (Experiment 1) and a verbal task (Experiment 2) with regard to a condition in which note names were printed inside note pictures in congruent positions.

  18. Qualifications Frameworks: The Avenue towards the Convergence of European Higher Education?

    ERIC Educational Resources Information Center

    Karseth, Berit; Solbrekke, Tone Dyrdal

    2010-01-01

    This article analyses one of the most important aspects of the journey towards the vision of a European Higher Education Area, namely the development of a "new architecture" in which compatible qualifications frameworks are one of the main building blocks. The overall question addressed concerns how and whether signatory countries of the Bologna…

  19. Brief Communication: Future avenues for permafrost science from the perspective of early career researchers

    NASA Astrophysics Data System (ADS)

    Fritz, M.; Deshpande, B. N.; Bouchard, F.; Högström, E.; Malenfant-Lepage, J.; Morgenstern, A.; Nieuwendam, A.; Oliva, M.; Paquette, M.; Rudy, A. C. A.; Siewert, M. B.; Sjöberg, Y.; Weege, S.

    2015-08-01

    Accelerating climate change and increased economic and environmental interests in permafrost-affected regions have resulted in an acute need for more directed permafrost research. In June 2014, 88 early career researchers convened to identify future priorities for permafrost research. This multidisciplinary forum concluded that five research topics deserve greatest attention: permafrost landscape dynamics, permafrost thermal modeling, integration of traditional knowledge, spatial distribution of ground ice, and engineering issues. These topics underline the need for integrated research across a spectrum of permafrost-related domains and constitute a contribution to the Third International Conference on Arctic Research Planning (ICARP III).

  20. Brief Communication: Future avenues for permafrost science from the perspective of early career researchers

    NASA Astrophysics Data System (ADS)

    Fritz, M.; Deshpande, B. N.; Bouchard, F.; Högtröm, E.; Lepage, J.; Morgenstern, A.; Nieuwendam, A.; Oliva, M.; Paquette, M.; Rudy, A. C. A.; Siewert, M. B.; Sjöberg, Y.; Weege, S.

    2015-02-01

    Accelerating climate change and increased economic and environmental interest in permafrost-affected regions have resulted in an acute need for more directed permafrost research. In June 2014, 88 early career researchers convened to identify future priorities for permafrost research. This multidisciplinary forum concluded that five research topics deserve greatest attention: permafrost landscape dynamics; permafrost thermal modelling; integration of traditional knowledge; spatial analysis of permafrost types and vulnerability; and engineering issues. These topics underline the need for integrated research across a spectrum of permafrost-related domains and constitute a contribution to the Third International Conference on Arctic Research Planning (ICARP III).

  1. Integrating movement ecology with biodiversity research - exploring new avenues to address spatiotemporal biodiversity dynamics.

    PubMed

    Jeltsch, Florian; Bonte, Dries; Pe'er, Guy; Reineking, Björn; Leimgruber, Peter; Balkenhol, Niko; Schröder, Boris; Buchmann, Carsten M; Mueller, Thomas; Blaum, Niels; Zurell, Damaris; Böhning-Gaese, Katrin; Wiegand, Thorsten; Eccard, Jana A; Hofer, Heribert; Reeg, Jette; Eggers, Ute; Bauer, Silke

    2013-01-01

    Movement of organisms is one of the key mechanisms shaping biodiversity, e.g. the distribution of genes, individuals and species in space and time. Recent technological and conceptual advances have improved our ability to assess the causes and consequences of individual movement, and led to the emergence of the new field of 'movement ecology'. Here, we outline how movement ecology can contribute to the broad field of biodiversity research, i.e. the study of processes and patterns of life among and across different scales, from genes to ecosystems, and we propose a conceptual framework linking these hitherto largely separated fields of research. Our framework builds on the concept of movement ecology for individuals, and demonstrates its importance for linking individual organismal movement with biodiversity. First, organismal movements can provide 'mobile links' between habitats or ecosystems, thereby connecting resources, genes, and processes among otherwise separate locations. Understanding these mobile links and their impact on biodiversity will be facilitated by movement ecology, because mobile links can be created by different modes of movement (i.e., foraging, dispersal, migration) that relate to different spatiotemporal scales and have differential effects on biodiversity. Second, organismal movements can also mediate coexistence in communities, through 'equalizing' and 'stabilizing' mechanisms. This novel integrated framework provides a conceptual starting point for a better understanding of biodiversity dynamics in light of individual movement and space-use behavior across spatiotemporal scales. By illustrating this framework with examples, we argue that the integration of movement ecology and biodiversity research will also enhance our ability to conserve diversity at the genetic, species, and ecosystem levels.

  2. Tethers in space: Birth and growth of a new avenue to space utilization

    NASA Technical Reports Server (NTRS)

    Vontiesenhausen, G.

    1984-01-01

    The evolution of the ideas of tether applications in space are traced from its origin in the last century past a dormant period of sixty-five years to the mid-seventies. At that time as a consequence of major revival efforts, NASA entered into serious investigations of the theoretical and practical feasibility of a large number of tethered concepts in space. These efforts culminated in the establishment of the Tethered Satellite System Project now at NASA in the advanced development phase. Extensive planning efforts are described, first, through a Tether Applications in Space Workshop which generated additional concepts and provided overall assessments and recommendations to NASA, and then through a NASA inter-center Tether Applications in Space Task Group which generated a four year program plan in the areas of further studies, technology, work and science and applications of tethers in space. An outlook into the future of tether applications that approaches some of the goals of the early visionaries is offered.

  3. Recent Developments in Neurofibromatoses and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues

    PubMed Central

    Rauen, Katherine A.; Huson, Susan M.; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H.; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M.; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H.; Zenker, Martin; Upadhyaya, Meena

    2014-01-01

    Neurofibromatosis type 1 was the first RASopathy and is now one of many RASopathies that are caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Their common underlying pathogenetic etiology causes significant overlap in phenotypic features which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium “Recent Developments in Neurofibromatoses and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues” chronicle this timely and topical clinical translational research symposium. The overarching goal was to bring together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras pathway syndromes to discuss the most state-of-the-art basic science and clinical issues in an effort to spark collaborations directed towards the best practices and therapies for individuals with RASopathies. PMID:25393061

  4. Re-experiencing traumatic events in PTSD: new avenues in research on intrusive memories and flashbacks

    PubMed Central

    Brewin, Chris R.

    2015-01-01

    Posttraumatic flashbacks, consisting of the intrusive re-experiencing of traumatic experiences in the present, have been more clearly defined for the first time in DSM-5 and have been identified as a unique symptom of posttraumatic stress disorder in the proposed ICD-11 diagnostic criteria. Relatively little research into flashbacks has been conducted, however, and new research efforts are required to understand the cognitive and biological basis of this important symptom. In addition, there is considerable scope for research into how flashbacks should be assessed and into flashbacks occurring in different contexts, such as psychosis or intensive care. PMID:25994019

  5. Unlocking the Genetic Diversity of Maize Landraces with Doubled Haploids Opens New Avenues for Breeding

    PubMed Central

    Strigens, Alexander; Schipprack, Wolfgang; Reif, Jochen C.; Melchinger, Albrecht E.

    2013-01-01

    Landraces are valuable genetic resources for broadening the genetic base of elite germplasm in maize. Extensive exploitation of landraces has been hampered by their genetic heterogeneity and heavy genetic load. These limitations may be overcome by the in-vivo doubled haploid (DH) technique. A set of 132 DH lines derived from three European landraces and 106 elite flint (EF) lines were genotyped for 56,110 single nucleotide polymorphism (SNP) markers and evaluated in field trials at five locations in Germany in 2010 for several agronomic traits. In addition, the landraces were compared with synthetic populations produced by intermating DH lines derived from the respective landrace. Our objectives were to (1) evaluate the phenotypic and molecular diversity captured within DH lines derived from European landraces, (2) assess the breeding potential (usefulness) of DH lines derived from landraces to broaden the genetic base of the EF germplasm, and (3) compare the performance of each landrace with the synthetic population produced from the respective DH lines. Large genotypic variances among DH lines derived from landraces allowed the identification of DH lines with grain yields comparable to those of EF lines. Selected DH lines may thus be introgressed into elite germplasm without impairing its yield level. Large genetic distances of the DH lines to the EF lines demonstrated the potential of DH lines derived from landraces to broaden the genetic base of the EF germplasm. The comparison of landraces with their respective synthetic population showed no yield improvement and no reduction of phenotypic diversity. Owing to the low population structure and rapid decrease of linkage disequilibrium within populations of DH lines derived from landraces, these would be an ideal tool for association mapping. Altogether, the DH technology opens new opportunities for characterizing and utilizing the genetic diversity present in gene bank accessions of maize. PMID:23451190

  6. Reaching adolescent girls through social networking: a new avenue for smoking prevention messages.

    PubMed

    Struik, Laura Louise; Bottorff, Joan L; Jung, Mary; Budgen, Claire

    2012-09-01

    Because adolescent girls are being targeted on social networking sites by the tobacco industry, new online tobacco control (TC) initiatives are needed. The purpose of this interpretive descriptive study was to explore adolescent girls' perspectives on the use of social networking sites to deliver TC messages targeting young women. Focus groups were conducted with 17 girls aged 16 to 19. Seven TC messages were provided for evaluation and as context for discussion about the delivery of TC messages on social networking sites. Data were analyzed for themes, which included concerns about the effectiveness of current TC messages and the stereotypical representations of gender, factors perceived to influence the effectiveness of TC messages on social networking sites, and suggestions for enhancing the effectiveness of TC messages placed on social networking sites. Endorsement of TC messaging on social networking sites suggests that this medium is an untapped resource for smoking prevention.

  7. Religious and Spiritual Beliefs: An Avenue to Explore End-of-Life Issues

    ERIC Educational Resources Information Center

    Reiner, Summer M.

    2007-01-01

    This literature review highlights the relationship between spirituality and/or religion and how people respond in the face of impending death. Attitudes toward physician-assisted suicide and hospice are explored. The author also offers recommendations to counselors for addressing religious and spiritual concerns.

  8. Grassland-Cropping Rotations: An Avenue for Agricultural Diversification to Reconcile High Production with Environmental Quality

    NASA Astrophysics Data System (ADS)

    Lemaire, Gilles; Gastal, François; Franzluebbers, Alan; Chabbi, Abad

    2015-11-01

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity at all levels of organization, i.e., field, farm, landscape, and region. Therefore, we postulate that negative environmental impacts of modern agriculture are due more to production simplification than to inherent characteristics of agricultural productivity. Thus by enhancing diversity within agricultural systems, it should be possible to reconcile high quantity and quality of food production with environmental quality. Intensification of livestock and cropping systems separately within different specialized regions inevitably leads to unacceptable environmental impacts because of the overly uniform land use system in intensive cereal areas and excessive N-P loads in intensive animal areas. The capacity of grassland ecosystems to couple C and N cycles through microbial-soil-plant interactions as a way for mitigating the environmental impacts of intensive arable cropping system was analyzed in different management options: grazing, cutting, and ley duration, in order to minimize trade-offs between production and the environment. We suggest that integrated crop-livestock systems are an appropriate strategy to enhance diversity. Sod-based rotations can temporally and spatially capture the benefits of leys for minimizing environmental impacts, while still maintaining periods and areas of intensive cropping. Long-term experimental results illustrate the potential of such systems to sequester C in soil and to reduce and control N emissions to the atmosphere and hydrosphere.

  9. New avenues for regulation of lipid metabolism by thyroid hormones and analogs

    PubMed Central

    Senese, Rosalba; Lasala, Pasquale; Leanza, Cristina; de Lange, Pieter

    2014-01-01

    Weight loss due to negative energy balance is a goal in counteracting obesity and type 2 diabetes mellitus. The thyroid is known to be an important regulator of energy metabolism through the action of thyroid hormones (THs). The classic, active TH, 3,5,3′-triiodo-L-thyronine (T3) acts predominantly by binding to nuclear receptors termed TH receptors (TRs), that recognize TH response elements (TREs) on the DNA, and so regulate transcription. T3 also acts through “non-genomic” pathways that do not necessarily involve TRs. Lipid-lowering therapies have been suggested to have potential benefits, however, the establishment of comprehensive therapeutic strategies is still awaited. One drawback of using T3 in counteracting obesity has been the occurrence of heart rhythm disturbances. These are mediated through one TR, termed TRα. The end of the previous century saw the exploration of TH mimetics that specifically bind to TR beta in order to prevent cardiac disturbances, and TH derivatives such as 3,5-diiodo-L-thyronine (T2), that possess interesting biological activities. Several TH derivatives and functional analogs have low affinity for the TRs, and are suggested to act predominantly through non-genomic pathways. All this has opened new perspectives in thyroid physiology and TH derivative usage as anti-obesity therapies. This review addresses the pros and cons of these compounds, in light of their effects on energy balance regulation and on lipid/cholesterol metabolism. PMID:25538628

  10. New avenues for regulation of lipid metabolism by thyroid hormones and analogs.

    PubMed

    Senese, Rosalba; Lasala, Pasquale; Leanza, Cristina; de Lange, Pieter

    2014-01-01

    Weight loss due to negative energy balance is a goal in counteracting obesity and type 2 diabetes mellitus. The thyroid is known to be an important regulator of energy metabolism through the action of thyroid hormones (THs). The classic, active TH, 3,5,3'-triiodo-L-thyronine (T3) acts predominantly by binding to nuclear receptors termed TH receptors (TRs), that recognize TH response elements (TREs) on the DNA, and so regulate transcription. T3 also acts through "non-genomic" pathways that do not necessarily involve TRs. Lipid-lowering therapies have been suggested to have potential benefits, however, the establishment of comprehensive therapeutic strategies is still awaited. One drawback of using T3 in counteracting obesity has been the occurrence of heart rhythm disturbances. These are mediated through one TR, termed TRα. The end of the previous century saw the exploration of TH mimetics that specifically bind to TR beta in order to prevent cardiac disturbances, and TH derivatives such as 3,5-diiodo-L-thyronine (T2), that possess interesting biological activities. Several TH derivatives and functional analogs have low affinity for the TRs, and are suggested to act predominantly through non-genomic pathways. All this has opened new perspectives in thyroid physiology and TH derivative usage as anti-obesity therapies. This review addresses the pros and cons of these compounds, in light of their effects on energy balance regulation and on lipid/cholesterol metabolism.

  11. An Avenue for Challenging Sexism: Examining the High School Sociology Classroom

    ERIC Educational Resources Information Center

    Stevens, Kaylene Mae; Martell, Christopher C.

    2016-01-01

    In this interpretative qualitative study, the researchers investigated the beliefs and practices of six high school sociology teachers in relation to the teaching of gender. Using a feminist lens, this study employed mixed methods, analyzing teacher interviews, observations, and classroom artifacts. The results showed that the teachers viewed…

  12. [Media coverage of suicide: From the epidemiological observations to prevention avenues].

    PubMed

    Notredame, Charles-Édouard; Pauwels, Nathalie; Walter, Michel; Danel, Thierry; Vaiva, Guillaume

    2015-12-01

    Media coverage of suicide can result in increased morbi-mortality suicidal rates, due to an imitation process in those who are particularly vulnerable. This phenomenon is known as "Werther effect". Werther effect's magnitude depends on several qualitative and quantitative characteristics of the media coverage, in a dose-effect relationship. An extensive (in terms of audience and history repetition) and salient coverage (glorification of suicide, description of the suicidal method, etc.) increases the risk of contagion. Celebrities' suicide is particularly at risk of Werther effect. Media may also have a preventive role with respect to suicide. Indeed, according to "Papageno effect", journalists could, under certain conditions, help preventing suicide when reporting suicide stories. Two main theories in the field of social psychology have been proposed to account for Werther and Papageno effects: social learning theory and differential identification. Identification of Werther and Papageno effects uncovers new responsibilities and potentialities for the journalists in terms of public health. Their description provides a basis for promising targeted prevention actions.

  13. Pendular Proteins in Gases and New Avenues for Characterization of Macromolecules by Ion Mobility Spectrometry

    SciTech Connect

    Shvartsburg, Alexandre A.; Noskov, Sergei; Purves, Randy; Smith, Richard D.

    2009-04-21

    Polar molecules align in electric fields when the dipole energy (proportional to field intensity E × dipole moment p) exceeds the thermal rotational energy. Small molecules have low p and align only at inordinately high E or upon extreme cooling. Many biomacromolecules and ions are strong permanent dipoles and may align at E achievable in gases and room temperature. The collision cross sections of aligned ions with gas molecules generally differ from orientationally averaged quantities, affecting ion mobilities measured in ion mobility spectrometry (IMS). Field asymmetric waveform IMS (FAIMS) separates ions by the difference between mobilities at high and low E and hence can resolve and identify macroion conformers based on the mobility difference between pendular and free rotor states. An exceptional sensitivity of that difference to the ion geometry and charge distribution holds the potential for a powerful new method for separation and characterization of macromolecular species. Theory predicts that the pendular alignment of ions in gases at any E requires a minimum p depending on the ion mobility, gas pressure, and temperature. At ambient conditions used in current FAIMS systems, the p for realistic ions must exceed ~300 - 400 Debye. The dipole moments of proteins statistically increase with increasing mass, and such values are typical above ~30 kDa. FAIMS analyses of protein ions and complexes of ~30 - 130 kDa show an order-of-magnitude expansion of separation space compared to smaller proteins and other ions, consistent with expectations for the dipole-aligned regime.

  14. Whole-body turbo STIR MR imaging: controversies and avenues for development.

    PubMed

    Kavanagh, Eoin; Smith, Clare; Eustace, Stephen

    2003-09-01

    The idea of a non-ionizing high-resolution technique to screen the entire body for occult disease is immensely appealing. This article outlines an evolving technique, controversies and clinical application of whole-body scanning using MRI with turbo short tau inversion recovery tissue excitation.

  15. Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals

    PubMed Central

    Sargis, Robert M

    2015-01-01

    The global epidemic of metabolic disease is a clear and present danger to both individual and societal health. Understanding the myriad factors contributing to obesity and diabetes is essential for curbing their decades-long expansion. Emerging data implicate environmental endocrine disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes. The phenylsulfamide fungicide and anti-fouling agent tolylfluanid (TF) was recently added to the list of EDCs promoting metabolic dysfunction. Dietary exposure to this novel metabolic disruptor promoted weight gain, increased adiposity, and glucose intolerance as well as systemic and cellular insulin resistance. Interestingly, the increase in body weight and adipose mass was not a consequence of increased food consumption; rather, it may have resulted from disruptions in diurnal patterns of energy intake, raising the possibility that EDCs may promote metabolic dysfunction through alterations in circadian rhythms. While these studies provide further evidence that EDCs may promote the development of obesity and diabetes, many questions remain regarding the clinical factors that modulate patient-specific consequences of EDC exposure, including the impact of genetics, diet, lifestyle, underlying disease, pharmacological treatments, and clinical states of fat redistribution. Currently, little is known regarding the impact of these factors on an individual’s susceptibility to environmentally-mediated metabolic disruption. Advances in these areas will be critical for translating EDC science into the clinic to enable physicians to stratify an individual’s risk of developing EDC-induced metabolic disease and to provide direction for treating exposed patients. PMID:27011951

  16. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-82)

    SciTech Connect

    Howington, John

    2002-08-13

    Vegetation Management for twenty-four Substations in the Burley District. BPA proposes total vegetation management (bare ground) in the electrical substations, and, noxious weed management and maintenance of landscaping within the property boundaries of the listed facilities. These facilities are all located within the Burley District of the Idaho Falls Region.

  17. "Health law, ethics and policy: challenges and new avenues for the 21st century and new millennium".

    PubMed

    Bates, P W

    1999-01-01

    The 50th anniversary of the World Health Organization on 7th April 1998 stands at the dawn of a new century and millennium. These symbolic markers encourage reflection on past achievements, scrutiny of current problems, and contemplation of the possibilities and practicalities of coordinated action to promote the global vision of 'Health For All'. Will that global vision remain inspirational, important and inclusive enough to sustain policy commitment, and unite diverse regional, national and local customs and traditions in ethics, human rights and laws so as to overcome inequities in health status, and improve health systems and health services?"

  18. 75 FR 78978 - Record of Decision for the 158th Fighter Wing's Proposed Realignment of National Guard Avenue and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... meet recommended stand-off distance between perimeter fence and mission critical resources and personnel). The decision was based on matters discussed in the Final Environmental Impact Statement...

  19. Changing Course: Thurgood Marshall College Fund President Johnny Taylor Seeks New Partnerships and Avenues of Support for Public HBCUs

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    When veteran educator Dr. N. Joyce Payne handed the reins of the organization she founded, the Thurgood Marshall College Fund, to entertainment lawyer and board member Johnny Taylor, Taylor began pursuing a remake of the prestigious group that has turned it on its head in just a matter of months. Today, with just more than a year of leading the…

  20. Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons.

    PubMed

    Sampedro-Piquero, P; Castilla-Ortega, E; Zancada-Menendez, C; Santín, L J; Begega, A

    2016-08-25

    The use of more ethological animal models to study the neurobiology of anxiety has increased in recent years. We assessed the effect of an environmental enrichment (EE) protocol (24h/day over a period of two months) on anxiety-related behaviors when aged Wistar rats (21months old) were confronted with cat odor stimuli. Owing to the relationship between GABAergic interneurons and the anxiety-related neuronal network, we examined changes in the expression of Parvalbumin (PV) and 67kDa form of glutamic acid decarboxylase (GAD-67) immunoreactive cells in different brain regions involved in stress response. Behavioral results revealed that enriched rats traveled further and made more grooming behaviors during the habituation session. In the cat odor session, they traveled longer distances and they showed more active interaction with the odor stimuli and less time in freezing behavior. Zone analysis revealed that the enriched group spent more time in the intermediate zone according to the proximity of the predator odor. Regarding the neurobiological data, the EE increased the expression of PV-positive cells in some medial prefrontal regions (cingulate (Cg) and prelimbic (PL) cortices), whereas the GAD-67 expression in the basolateral amygdala was reduced in the enriched group. Our results suggest that EE is able to reduce anxiety-like behaviors in aged animals even when ethologically relevant stimuli are used. Moreover, GABAergic interneurons could be involved in mediating this resilient behavior. PMID:27235742

  1. Medical use of cannabis in Australia: "medical necessity" defences under current Australian law and avenues for reform.

    PubMed

    Martin, Charles

    2014-06-01

    The possession of cannabis is an offence in all Australian jurisdictions. No exception is made for medical use under any of the State and Territory Drug Acts, nor the Commonwealth's pharmaceutical regulation scheme. Nevertheless, questions remain about the scope for defences argued on the basis of necessitous medical use. More fundamentally the increasingly favourable light in which the medical use of cannabis is growing to be seen by state and national legislatures overseas raises important questions about the need for reform of Australian drug laws. This article explores those questions. PMID:25087368

  2. Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design1

    PubMed Central

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P.; Thorn, Katherine J.; Christianson, David W.

    2011-01-01

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design, and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of α,α-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2- methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional α-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase. PMID:21728378

  3. ASSESSING UST CORRECTIVE ACTION TECHNOLOGIES: LESSONS LEARNED ABOUT IN SITU AIR SPARGING AT THE DENISON AVENUE SITE - CLEVELAND, OH

    EPA Science Inventory

    In situ air sparging (IAS) has been proposed and installed at an increasing number of sites to address contamination in both the saturated and unsaturated zones. Because of the lack of experimental and substantive performance data, however, the actual performance and effectivene...

  4. Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy.

    PubMed

    Perney, Nicolas M; Braddick, Lucy; Jurna, Martin; Garbacik, Erik T; Offerhaus, Herman L; Serpell, Louise C; Blanch, Ewan; Holden-Dye, Lindy; Brocklesby, William S; Melvin, Tracy

    2012-01-01

    Coherent anti-Stokes Raman scattering (CARS) microscopy is applied for the first time for the evaluation of the protein secondary structure of polyglutamine (polyQ) aggregates in vivo. Our approach demonstrates the potential for translating information about protein structure that has been obtained in vitro by X-ray diffraction into a microscopy technique that allows the same protein structure to be detected in vivo. For these studies, fibres of polyQ containing peptides (D(2)Q(15)K(2)) were assembled in vitro and examined by electron microscopy and X-ray diffraction methods; the fibril structure was shown to be cross β-sheet. The same polyQ fibres were evaluated by Raman spectroscopy and this further confirmed the β-sheet structure, but indicated that the structure is highly rigid, as indicated by the strong Amide I signal at 1659 cm(-1). CARS spectra were simulated using the Raman spectrum taking into account potential non-resonant contributions, providing evidence that the Amide I signal remains strong, but slightly shifted to lower wavenumbers. Combined CARS (1657 cm(-1)) and multi-photon fluorescence microscopy of chimeric fusions of yellow fluorescent protein (YFP) with polyQ (Q40) expressed in the body wall muscle cells of Caenorhabditis elegans nematodes (1 day old adult hermaphrodites) revealed diffuse and foci patterns of Q40-YFP that were both fluorescent and exhibited stronger CARS (1657 cm(-1)) signals than in surrounding tissues at the resonance for the cross β-sheet polyQ in vitro. PMID:22911702

  5. Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.

    PubMed

    Makarev, Evgeny; Cantor, Charles; Zhavoronkov, Alex; Buzdin, Anton; Aliper, Alexander; Csoka, Anotonei Benjamin

    2014-12-01

    Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, "AMD Medicine", and discovered differential pathway activation profiles in samples of human RPE/choroid from AMD patients and controls. We identified 29 pathways in RPE-choroid AMD phenotypes: 27 pathways were activated in AMD compared to controls, and 2 pathways were activated in controls compared to AMD. In AMD, we identified a graded activation of pathways related to wound response, complement cascade, and cell survival. Also, there was downregulation of two pathways responsible for apoptosis. Furthermore, significant activation of pro-mitotic pathways is consistent with dedifferentiation and cell proliferation events, which occur early in the pathogenesis of AMD. Significantly, we discovered new global pathway activation signatures of AMD involved in the cell-based inflammatory response: IL-2, STAT3, and ERK. The ultimate aim of our research is to achieve a better understanding of signaling pathways involved in AMD pathology, which will eventually lead to better treatments. PMID:25543336

  6. 76 FR 22729 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant #1, Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... December 18, 2008 (73 FR 77067). In order to avoid an overlap in worker group coverage, the Department is..., Including On-Site Leased Workers From Caravan Knight, Detroit, MI; Amended Certification Regarding... Knight, Detroit, Michigan. The workers are engaged in the production of automotive engines. The...

  7. 76 FR 27366 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plants #1 And #2, Including On-Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... notice was published in the Federal Register on April 22, 2011 (76 FR 22731). The notice was amended on..., 2011 (76 FR 22729). At the request of a company official, the Department reviewed the certification for... And 2, Including On-Site Leased Workers from Caravan Knight, Detroit, MI; Amended...

  8. Drell-Yan process as an avenue to test a noncommutative standard model at the Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    J, Selvaganapathy; Das, Prasanta Kumar; Konar, Partha

    2016-06-01

    We study the Drell-Yan process at the Large Hadron Collider in the presence of the noncommutative extension of the standard model. Using the Seiberg-Witten map, we calculate the production cross section to first order in the noncommutative parameter Θμ ν . Although this idea has been evolving for a long time, only a limited amount of phenomenological analysis has been completed, and this was mostly in the context of the linear collider. An outstanding feature from this nonminimal noncommutative standard model not only modifies the couplings over the SM production channel but also allows additional nonstandard vertices which can play a significant role. Hence, in the Drell-Yan process, as studied in the present analysis, one also needs to account for the gluon fusion process at the tree level. Some of the characteristic signatures, such as oscillatory azimuthal distributions, are an outcome of the momentum-dependent effective couplings. We explore the noncommutative scale ΛNC≥0.4 TeV , considering different machine energy ranging from 7 to 13 TeV.

  9. Confirmatory/release survey of the property at 71 Pearce Avenue (Former EAD Building) in Tonawanda, New York

    SciTech Connect

    Salame-Alfie, A.; Alibozek, R.

    1995-12-31

    EAD Metallurgical, Inc., operated a facility in Tonawanda, New York, in which it utilized Americium 241 (Am-241) for the production of foil sources for use in smoke detectors. EAD was in operation between 1977 and 1983. By 1983, the company started losing money, and decided to relocate to Mexico. Before closing down its Tonawanda operation, however, it was required by the New York State Department of Labor (DOL) to decontaminate its facility to limits specified by DOL. No records of discharges to the sewer system were kept during this decontamination effort. Unsuccessful decontamination efforts by several EAD employees and contractors left the building contaminated, in particular the concrete floors and walls. To determine the scope of work for the decontamination project, staff from the New York State Departments of Health (DOH) and Environmental Conservation (DEC) conducted a Characterization Survey of the facility in 1993. This survey identified contamination levels of Am-241 in excess of release limits throughout the building, in the soil outside the facility, in pipes for sewage and interior drainage, and in an 8 x 8 x 11 foot sump pit in the building. DOH issued a request for proposals in early 1994 for the decontamination and subsequent decommissioning of the former EAD building, and NES/IES Inc. (NES) was awarded the contract to perform the remediation. DOH`s assignment was to provide an on-site presence to insure the completion of all agreed upon tasks, according to the terms of the contract and work plans submitted by NES. Additionally, the DOH staff acted as a liaison between NES, DOH, DEC and DOL central offices to review, comment and approve all changes or modifications to NES`s approach to the decontamination efforts. The assigned staff was also responsible for conducting confirmatory sampling and surveys of all areas deemed releasable to DOL and DEC criteria by NES.

  10. Biosynthesis of metallic nanoparticles using plant derivatives and their new avenues in pharmacological applications - An updated report.

    PubMed

    Kuppusamy, Palaniselvam; Yusoff, Mashitah M; Maniam, Gaanty Pragas; Govindan, Natanamurugaraj

    2016-07-01

    The field of nanotechnology mainly encompasses with biology, physics, chemistry and material sciences and it develops novel therapeutic nanosized materials for biomedical and pharmaceutical applications. The biological syntheses of nanoparticles are being carried out by different macro-microscopic organisms such as plant, bacteria, fungi, seaweeds and microalgae. The biosynthesized nanomaterials have been effectively controlling the various endemic diseases with less adverse effect. Plant contains abundant natural compounds such as alkaloids, flavonoids, saponins, steroids, tannins and other nutritional compounds. These natural products are derived from various parts of plant such as leaves, stems, roots shoots, flowers, barks, and seeds. Recently, many studies have proved that the plant extracts act as a potential precursor for the synthesis of nanomaterial in non-hazardous ways. Since the plant extract contains various secondary metabolites, it acts as reducing and stabilizing agents for the bioreduction reaction to synthesized novel metallic nanoparticles. The non-biological methods (chemical and physical) are used in the synthesis of nanoparticles, which has a serious hazardous and high toxicity for living organisms. In addition, the biological synthesis of metallic nanoparticles is inexpensive, single step and eco-friendly methods. The plants are used successfully in the synthesis of various greener nanoparticles such as cobalt, copper, silver, gold, palladium, platinum, zinc oxide and magnetite. Also, the plant mediated nanoparticles are potential remedy for various diseases such as malaria, cancer, HIV, hepatitis and other acute diseases.

  11. Social Media as Avenue for Personal Learning for Educators: Personal Learning Networks Encourage Application of Knowledge and Skills

    ERIC Educational Resources Information Center

    Eller, Linda S.

    2012-01-01

    Social media sites furnish an online space for a community of practice to create relationships and trust, collaboration and connections, and a personal learning environment. Social networking sites, both public and private, have common elements: member profiles, groups, discussions, and forums. A community of practice brings participants together…

  12. The emerging role of epigenetics in pulmonary arterial hypertension: an important avenue for clinical trials (2015 Grover Conference Series)

    PubMed Central

    Ryan, John J.

    2016-01-01

    Abstract Epigenetics is an emerging field of research and clinical trials in cancer therapy that also has applications for pulmonary arterial hypertension (PAH), as there is evidence that epigenetic control of gene expression plays a significant role in PAH. The three types of epigenetic modification include DNA methylation, histone modification, and RNA interference. All three have been shown to be involved in the development of PAH. Currently, the enzymes that perform these modifications are the primary targets of neoplastic therapy. These targets are starting to be explored for therapies in PAH, mostly in animal models. In this review we summarize the basics of each type of epigenetic modification and the known sites and molecules involved in PAH, as well as current targets and prospects for clinical trials. PMID:27683604

  13. Biosynthesis of metallic nanoparticles using plant derivatives and their new avenues in pharmacological applications - An updated report.

    PubMed

    Kuppusamy, Palaniselvam; Yusoff, Mashitah M; Maniam, Gaanty Pragas; Govindan, Natanamurugaraj

    2016-07-01

    The field of nanotechnology mainly encompasses with biology, physics, chemistry and material sciences and it develops novel therapeutic nanosized materials for biomedical and pharmaceutical applications. The biological syntheses of nanoparticles are being carried out by different macro-microscopic organisms such as plant, bacteria, fungi, seaweeds and microalgae. The biosynthesized nanomaterials have been effectively controlling the various endemic diseases with less adverse effect. Plant contains abundant natural compounds such as alkaloids, flavonoids, saponins, steroids, tannins and other nutritional compounds. These natural products are derived from various parts of plant such as leaves, stems, roots shoots, flowers, barks, and seeds. Recently, many studies have proved that the plant extracts act as a potential precursor for the synthesis of nanomaterial in non-hazardous ways. Since the plant extract contains various secondary metabolites, it acts as reducing and stabilizing agents for the bioreduction reaction to synthesized novel metallic nanoparticles. The non-biological methods (chemical and physical) are used in the synthesis of nanoparticles, which has a serious hazardous and high toxicity for living organisms. In addition, the biological synthesis of metallic nanoparticles is inexpensive, single step and eco-friendly methods. The plants are used successfully in the synthesis of various greener nanoparticles such as cobalt, copper, silver, gold, palladium, platinum, zinc oxide and magnetite. Also, the plant mediated nanoparticles are potential remedy for various diseases such as malaria, cancer, HIV, hepatitis and other acute diseases. PMID:27330378

  14. Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons.

    PubMed

    Sampedro-Piquero, P; Castilla-Ortega, E; Zancada-Menendez, C; Santín, L J; Begega, A

    2016-08-25

    The use of more ethological animal models to study the neurobiology of anxiety has increased in recent years. We assessed the effect of an environmental enrichment (EE) protocol (24h/day over a period of two months) on anxiety-related behaviors when aged Wistar rats (21months old) were confronted with cat odor stimuli. Owing to the relationship between GABAergic interneurons and the anxiety-related neuronal network, we examined changes in the expression of Parvalbumin (PV) and 67kDa form of glutamic acid decarboxylase (GAD-67) immunoreactive cells in different brain regions involved in stress response. Behavioral results revealed that enriched rats traveled further and made more grooming behaviors during the habituation session. In the cat odor session, they traveled longer distances and they showed more active interaction with the odor stimuli and less time in freezing behavior. Zone analysis revealed that the enriched group spent more time in the intermediate zone according to the proximity of the predator odor. Regarding the neurobiological data, the EE increased the expression of PV-positive cells in some medial prefrontal regions (cingulate (Cg) and prelimbic (PL) cortices), whereas the GAD-67 expression in the basolateral amygdala was reduced in the enriched group. Our results suggest that EE is able to reduce anxiety-like behaviors in aged animals even when ethologically relevant stimuli are used. Moreover, GABAergic interneurons could be involved in mediating this resilient behavior.

  15. Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues

    PubMed Central

    Dravis, Christopher; Henkemeyer, Mark

    2011-01-01

    We report that the disruption of bidirectional signaling between ephrin-B2 and EphB receptors impairs morphogenetic cell-cell septation and closure events during development of the embryonic midline. A novel role for reverse signaling is identified in tracheoesophageal foregut septation, as animals lacking the cytoplasmic domain of ephrin-B2 present with laryngotracheoesophageal cleft (LTEC), while both EphB2/EphB3 forward signaling and ephrin-B2 reverse signaling are shown to be required for midline fusion of the palate. In a third midline event, EphB2/EphB3 are shown to mediate ventral abdominal wall closure by acting principally as ligands to stimulate ephrin-B reverse signaling. Analysis of new ephrin-B26YFΔV and ephrin-B2ΔV mutants that specifically ablate ephrin-B2 tyrosine phosphorylation- and/or PDZ domain-mediated signaling indicate there are at least two distinct phosphorylation-independent components of reverse signaling. These involve both PDZ domain interactions and a non-canonical SH2/PDZ-independent form of reverse signaling that may utilize associations with claudin family tetraspan molecules, as EphB2 and activated ephrin-B2 molecules are specifically co-localized with claudins in epithelia at the point of septation. Finally, the developmental phenotypes described here mirror common human midline birth defects found with the VACTERL association, suggesting a molecular link to bidirectional signaling through B-subclass Ephs and ephrins. PMID:21539827

  16. Electroretinographic modifications induced by agomelatine: a novel avenue to the understanding of the claimed antidepressant effect of the drug?

    PubMed Central

    Fornaro, Michele; Bandini, Fabio; Cestari, Luca; Cordano, Christian; Ogliastro, Carla; Albano, Claudio; De Berardis, Domenico; Martino, Matteo; Escelsior, Andrea; Rocchi, Giulio; Fornaro, Pantaleo; De Pasquale, Concetta

    2014-01-01

    Background Agomelatine, the first melatonergic antidepressant, has been postulated to enhance the dopaminergic activity at the central nervous system by 5-hydroxytryptamine receptor type 2C (5-HT2C) antagonism, yet the impact of melatonergic agonism on this pathway is unclear. Previous studies employing simplified, yet reliable, proxy (retinal) measures of the central nervous system dopaminergic activity, namely the standard electroretinogram (ERG) technique, suggested a reduction of the dopaminergic activity of the main ERG parameter, the b-wave, by pure melatonin, notably a hormone devoid of any antidepressant activity. Therefore, the antidepressant effects of the melatonergic antidepressant drug agomelatine should be reflected by a differential b-wave trend at ERG versus the effect exerted by pure melatonin, which was eventually found to be due to a contrasting effect on central dopaminergic transmission between the two drugs. Objective and methods The aim of the present preliminary ERG study carried out on healthy volunteers (n=23) receiving agomelatine was to explore the impact of this antidepressant drug on b-wave amplitude and latency of cones in daylight conditions using standard ERG. Results As postulated, agomelatine induced an enhancement of retinal dopaminergic activity, in contrast to what has been previously documented for melatonin. Conclusion Given the limits of this explorative study, especially the lack of a control group and that of a luminance response function to measure retinal sensitivity, further studies in clinical samples are recommended to allow more tenable conclusions about the potential role of ERG in discriminating between 5-HT antagonism and melatonergic (MT) agonism in relationship to the claimed antidepressant effect of agomelatine. PMID:24899809

  17. The Use of Several Diverse Methodologies for Increasing Pupil Achievement: Wesley Avenue Elementary School, 1972-73.

    ERIC Educational Resources Information Center

    Russell, Gail; Gaskin, Comer

    Since many of the children attending Wesley School come from homes which have a low income base, it qualifies for federally funded compensatory services. The educational program at Wesley was unique in that the various compensatory programs in operation reflected the use of several diverse methodologies for improving pupil achievement. The total…

  18. Momentum and Turbulent Kinetic Energy Budgets Within the Park Avenue Street Canyon During the Joint Urban 2003 Field Campaign

    NASA Astrophysics Data System (ADS)

    Nelson, Matthew A.; Pardyjak, Eric R.; Klein, Petra

    2011-07-01

    Very few attempts have so far been made to quantify the momentum and turbulent kinetic energy (TKE) budgets within real urban canopies. In this study, sonic anemometer data obtained during the Joint Urban 2003 field campaign in Oklahoma City, U.S.A. were used for calculating the momentum and TKE budgets within a real-world urban street canyon. Sonic anemometers were deployed on multiple towers in the lower half of the canyon. Gradients in all three principal directions were included in the analyses. The storage and buoyancy terms were found to have negligible contributions to both the momentum and TKE budgets. The momentum budgets were generally found to be more complex than a simple balance of two physical processes. The horizontal terms were found to have significant and sometimes dominant contributions to the momentum and TKE budgets.

  19. (13)CHD2-CEST NMR spectroscopy provides an avenue for studies of conformational exchange in high molecular weight proteins.

    PubMed

    Rennella, Enrico; Huang, Rui; Velyvis, Algirdas; Kay, Lewis E

    2015-10-01

    An NMR experiment for quantifying slow (millisecond) time-scale exchange processes involving the interconversion between visible ground state and invisible, conformationally excited state conformers is presented. The approach exploits chemical exchange saturation transfer (CEST) and makes use of (13)CHD2 methyl group probes that can be readily incorporated into otherwise highly deuterated proteins. The methodology is validated with an application to a G48A Fyn SH3 domain that exchanges between a folded conformation and a sparsely populated and transiently formed unfolded ensemble. Experiments on a number of different protein systems, including a 360 kDa half-proteasome, establish that the sensitivity of this (13)CHD2 (13)C-CEST technique can be upwards of a factor of 5 times higher than for a previously published (13)CH3 (13)C-CEST approach (Bouvignies and Kay in J Biomol NMR 53:303-310, 2012), suggesting that the methodology will be powerful for studies of conformational exchange in high molecular weight proteins.

  20. A new avenue to the synthesis of GAG-mimicking polymers highly promoting neural differentiation of embryonic stem cells.

    PubMed

    Wang, Mengmeng; Lyu, Zhonglin; Chen, Gaojian; Wang, Hongwei; Yuan, Yuqi; Ding, Kaiguo; Yu, Qian; Yuan, Lin; Chen, Hong

    2015-10-28

    A new strategy for the fabrication of glycosaminoglycan (GAG) analogs was proposed by copolymerizing the sulfonated unit and the glyco unit, 'splitted' from the sulfated saccharide building blocks of GAGs. The synthetic polymers can promote cell proliferation and neural differentiation of embryonic stem cells with the effects even better than those of heparin.

  1. Stroke recovery and prevention barriers among young African-American men: Potential avenues to reduce health disparities

    PubMed Central

    Blixen, Carol; Perzynski, Adam; Cage, Jamie; Smyth, Kathleen; Moore, Shirley; Sila, Cathy; Pundik, Svetlana; Sajatovic, Martha

    2016-01-01

    Background African-Americans (AA) who experience a first time stroke are younger, and have double the stroke rate and more post-stroke complications than other Americans. Objective To assess perceived post-stroke care barriers among younger AA men and their care partners (CPs) in order to inform development of acceptable and effective improvements in post-stroke care for this high-risk group. Methods Ten community-dwelling AA stroke survivors and 7 of their care partners (CPs) participated in focus groups and advisory board meetings. Survivors had stroke or transient ischemic attack within one year and a Barthel ADL Index >60. In focus groups, using a semi-structured interview guide, survivors and CPs identified self-perceived barriers and facilitators to post-stroke care. Thematic analysis of session transcripts and the constant comparative method were used to generate themes. Results Survivor age ranged from 34 to 64. Mean Barthel was 95.5. CPs, all AA women, ranged in age from 49–61. CPs were 5 wives, a fianceé and a niece. Participants cited multiple personal, social, and societal stroke recovery challenges. While hypertension and smoking risks were acknowledged, stress, depression, PTSD, anger/frustration, personal identity change, and difficulty communicating unique needs as AA men were much more frequently noted. Facilitators included family support, stress reduction and dietary changes. Conclusions Younger AA men and their CPs perceive multiple post-stroke care barriers. Biological risk reduction education may not capture all salient aspects of health management for AA stroke survivors. Leveraging family and community strengths, addressing psychological health, and directly engaging patients with healthcare teams may improve care management. PMID:25341388

  2. A Random Walk Down University Avenue: Life Paths, Life Events, and Personality Trait Change at the Transition to University Life

    PubMed Central

    Lüdtke, Oliver; Roberts, Brent W.; Trautwein, Ulrich; Nagy, Gabriel

    2013-01-01

    This longitudinal study examined the relation between continuity and change in the Big Five personality traits and life events. Approximately 2,000 German students were tracked from high school to university or to vocational training or work, with 3 assessments over 4 years. Life events were reported retrospectively at the 2nd and 3rd assessment. Latent curve analyses were used to assess change in personality traits, revealing 3 main findings. First, mean-level changes in the Big Five factors over the 4 years were in line with the maturity principle, indicating increasing psychological maturity from adolescence to young adulthood. Second, personality development was characterized by substantive individual differences relating to the life path followed; participants on a more vocationally oriented path showed higher increases in conscientiousness and lower increases in agreeableness than their peers at university. Third, initial level and change in the Big Five factors (especially Neuroticism and Extraversion) were linked to the occurrence of aggregated as well as single positive and negative life events. The analyses suggest that individual differences in personality development are associated with life transitions and individual life experiences. PMID:21744977

  3. Solution NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation.

    PubMed

    Rosenzweig, Rina; Kay, Lewis E

    2016-02-10

    Solution-based NMR spectroscopy has been an important tool for studying the structure and dynamics of relatively small proteins and protein complexes with aggregate molecular masses under approximately 50 kDa. The development of new experiments and labeling schemes, coupled with continued improvements in hardware, has significantly reduced this size limitation, enabling atomic-resolution studies of molecular machines in the 1 MDa range. In this Perspective, some of the important advances are highlighted in the context of studies of molecular chaperones involved in protein disaggregation. New insights into the structural biology of disaggregation obtained from NMR studies are described, focusing on the unique capabilities of the methodology for obtaining atomic-resolution descriptions of dynamic systems.

  4. In vivo pharmacological evaluations of novel olanzapine analogues in rats: a potential new avenue for the treatment of schizophrenia.

    PubMed

    Jafari, Somayeh; Huang, Xu-Feng; Andrews, Jessica L; Fernandez-Enright, Francesca

    2013-01-01

    Olanzapine (Olz) is one of the most effective antipsychotic drugs commonly used for treating schizophrenia. Unfortunately, Olz administration is associated with severe weight gain and metabolic disturbances. Both patients and clinicians are highly interested in the development of new antipsychotics which are as effective as atypical antipsychotics but which have a lower propensity to induce metabolic side effects. In the present study, we examined two new derivatives of Olz; OlzEt (2-ethyl-4-(4'-methylpiperazin-1'-yl)-10Hbenzo[b]thieno[2,3-e][1,4]diazepine), and OlzHomo (2-ethyl-4-(4'-methyl-1',4'-diazepan-1'-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepine), for their tendency to induce weight gain in rats. Weight gain and metabolic changes were measured in female Sprague Dawley rats. Animals were treated orally with Olz, OlzEt, OlzHomo (3 or 6 mg/kg/day), or vehicle (n = 8), three times daily at eight-hour intervals for 5 weeks. Furthermore, a phencyclidine (PCP)-treated rat model was used to examine the prevention of PCP-induced hyperlocomotor activity relevant for schizophrenia therapy. Male Sprague Dawley rats were pre-treated with a single dose (3 mg/kg/day) of Olz, OlzEt, OlzHomo, or vehicle (n = 12), for 2 weeks. Locomotor activity was recorded following a subcutaneous injection with either saline or PCP (10 mg/kg). Olz was found to induce weight gain, hyperphagia, visceral fat accumulation, and metabolic changes associated with reduced histamatergic H1 receptor density in the hypothalamus of treated rats. In contrast, OlzEt and OlzHomo presented promising antipsychotic effects, which did not induce weight gain or fat deposition in the treated animals. Behavioural analysis showed OlzEt to attenuate PCP-induced hyperactivity to a level similar to that of Olz; however, OlzHomo showed a lower propensity to inhibit these stereotyped behaviours. Our data suggest that the therapeutic effectiveness of OlzHomo may be delivered at a higher dose than that of Olz and OlzEt. Overall, OlzEt and OlzHomo may offer a better pharmacological profile than Olz for treating patients with schizophrenia. Clinical trials are needed to test this hypothesis.

  5. Super Searchers on Madison Avenue: Top Advertising and Marketing Professionals Share Their Online Research Strategies. Super Searchers, Volume XI.

    ERIC Educational Resources Information Center

    Villamora, Grace Avellana

    This book presents interviews with 13 research professionals that contain favorite online search strategies and research tools, anecdotes, "how to" survival tips, and best-practice examples. The appendix lists referenced sites and sources in the following categories: (1) online resources; (2) books, annuals, newsletters, magazines, and articles;…

  6. The emerging role of epigenetics in pulmonary arterial hypertension: an important avenue for clinical trials (2015 Grover Conference Series)

    PubMed Central

    Ryan, John J.

    2016-01-01

    Abstract Epigenetics is an emerging field of research and clinical trials in cancer therapy that also has applications for pulmonary arterial hypertension (PAH), as there is evidence that epigenetic control of gene expression plays a significant role in PAH. The three types of epigenetic modification include DNA methylation, histone modification, and RNA interference. All three have been shown to be involved in the development of PAH. Currently, the enzymes that perform these modifications are the primary targets of neoplastic therapy. These targets are starting to be explored for therapies in PAH, mostly in animal models. In this review we summarize the basics of each type of epigenetic modification and the known sites and molecules involved in PAH, as well as current targets and prospects for clinical trials.

  7. Stakeholders’ perception on the organization of chronic care: a SWOT analysis to draft avenues for health care reforms

    PubMed Central

    2014-01-01

    Background Adequate care for individuals living with chronic illnesses calls for a healthcare system redesign, moving from acute, disease-centered to patient-centered models. The aim of this study was to identify Belgian stakeholders’ perceptions on the strengths, weaknesses, opportunities and threats of the healthcare system for people with chronic diseases in Belgium. Methods Four focus groups were held with stakeholders from the micro and meso level, in addition to two interviews with stakeholders who could not attend the focus group sessions. Data collection and the discussion were based on the Chronic Care model. Thematic analysis of the transcripts allowed for the identification of the strengths, weaknesses, opportunities and threats of the current health care system with focus on chronic care. Results Informants stressed the overall good quality of the acute health care system and the level of reimbursement of care as an important strength of the current system. In contrast, the lack of integration of care was identified as one of the biggest weaknesses of today’s health care system, along with the unclear definitions of the roles and functions of health professionals involved in care processes. Patient education to support self-management exists for patients with diabetes and/or terminal kidney failure but not for those living with other or multiple chronic conditions. The current overall fee-for-service system is a barrier to integrated care, as are the lack of incentives for integrated care. Attending multidisciplinary meetings, for example, is underfinanced to date. Finally, clinical information systems lack interoperability, which further impedes the information flow across settings and disciplines. Conclusion Our study’s methods allowed for the identification of problematic domains in the health system for people living with chronic conditions. These findings provided useful insights surrounding perceived priorities. This methodology may inspire other countries faced with the challenge of drafting reforms to tackle the issue of chronic care. PMID:24742204

  8. 77 FR 74504 - Proposed Low-Effect Habitat Conservation Plan for the State-Route 99/Cartmill Avenue Interchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... fairy shrimp and the San Joaquin kit fox. The applicant would implement a conservation strategy program... listed species will be included as covered species in the applicant's proposed HCP: San Joaquin kit fox... the Endangered San Joaquin Kit Fox Prior to or During Ground Disturbance.'' Other avoidance...

  9. A novel potential therapeutic avenue for autism: Design, synthesis and pharmacophore generation of SSRIs with dual action

    PubMed Central

    Ghoneim, Ola M.; Ibrahim, Diaa A.; El-Deeb, Ibrahim M.; Lee, So Ha; Booth, Raymond G.

    2014-01-01

    Autism symptoms are currently modulated by Selective Serotonin Reuptake Inhibitors (SSRIs). SSRIs slow onset of action limits their efficiency. The established synergistic activity of SSRIs and 5HT1B/1D autoreceptors antagonists motivated us to incorporate SSRIs and 5HT1B/1D antagonists in one ‘hybrid’ molecule. A library of virtual ‘hybrid’ molecules was designed using the tethering technique. A pharmacophore model was generated derived from 16 structurally diverse SSRIs (Ki = 0.013–5000 nM) and used as 3D query. Compounds with fit values (≥2) were chosen for synthesis and subsequent in vitro biological evaluation. Our pharmacophore model is a promising milestone to a class of SSRIs with dual action. PMID:21982496

  10. The emerging role of epigenetics in pulmonary arterial hypertension: an important avenue for clinical trials (2015 Grover Conference Series).

    PubMed

    Huston, Jessica H; Ryan, John J

    2016-09-01

    Epigenetics is an emerging field of research and clinical trials in cancer therapy that also has applications for pulmonary arterial hypertension (PAH), as there is evidence that epigenetic control of gene expression plays a significant role in PAH. The three types of epigenetic modification include DNA methylation, histone modification, and RNA interference. All three have been shown to be involved in the development of PAH. Currently, the enzymes that perform these modifications are the primary targets of neoplastic therapy. These targets are starting to be explored for therapies in PAH, mostly in animal models. In this review we summarize the basics of each type of epigenetic modification and the known sites and molecules involved in PAH, as well as current targets and prospects for clinical trials. PMID:27683604

  11. Red blood cells open promising avenues for longitudinal studies of ageing in laboratory, non-model and wild animals.

    PubMed

    Stier, Antoine; Reichert, Sophie; Criscuolo, Francois; Bize, Pierre

    2015-11-01

    Ageing is characterized by a progressive deterioration of multiple physiological and molecular pathways, which impair organismal performance and increase risks of death with advancing age. Hence, ageing studies must identify physiological and molecular pathways that show signs of age-related deterioration, and test their association with the risk of death and longevity. This approach necessitates longitudinal sampling of the same individuals, and therefore requires a minimally invasive sampling technique that provides access to the larger spectrum of physiological and molecular pathways that are putatively associated with ageing. The present paper underlines the interest in using red blood cells (RBCs) as a promising target for longitudinal studies of ageing in vertebrates. RBCs provide valuable information on the following six pathways: cell maintenance and turnover (RBC number, size, and heterogeneity), glucose homeostasis (RBC glycated haemoglobin), oxidative stress parameters, membrane composition and integrity, mitochondrial functioning, and telomere dynamics. The last two pathways are specific to RBCs of non-mammalian species, which possess a nucleus and functional mitochondria. We present the current knowledge about RBCs and age-dependent changes in these pathways in non-model and wild species that are especially suitable to address questions related to ageing using longitudinal studies. We discuss how the different pathways relate with survival and lifespan and give information on their genetic and environmental determinants to appraise their evolutionary potential.

  12. Radiation-induced carboxylation of chloroacetate ion: An avenue for making value-added products from carbon dioxide

    SciTech Connect

    Getoff, N.

    1997-12-31

    The major theme of this paper is the radiation-induced carboxylation monochloroacetic acid. The formation of various products originating from chloroacetate ion, CO{sub 2}, CO or/and formate was studied as a function of substrate concentration, absorbed radiation dose etc. Malonic acid and oxalic acid were found to be the major products in addition to succinic, maleic and citric acids. Small yields of other organic compounds were also found. The results from these studies will be reported.

  13. Radiological assessment report for the Lansdowne property, 105-107 East Stratford Avenue, Lansdowne, Pennsylvania, October-December 1984

    SciTech Connect

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Flynn, K.F.

    1985-09-01

    Areas with elevated levels of radioactivity were found throughout both residences, as well as on the surrounding property. Contamination was also found in the garage behind the 105 East structure. The 105 East residence had substantially more contamination than the 107 East residence, as was expected. The chimneys, particularly the rear chimney, from the 105 East residence had extensive contamination, indicating that contaminated materials may have been burned at the site. The high background radiation emanating from this residence made it difficult to establish the relatively lower levels of contamination in the 107 East residence. The property surrounding the 105 East residence was found to have substantial contamination scattered throughout, with the highest level occurring in the backyard. The soil surface contamination seemed to drop markedly (but not entirely) at the property lines. The property surrounding 107 East was found to be less contaminated, although the background radiation emanating from the adjoining area made it difficult to establish the degree of surface or near-surface contamination from surface surveys. Subsurface investigation of the soil surrounding the structure indicated that radium contamination was widespread and extended to a depth of eight feet at some locations. There was evidence that some of this contamination extended onto adjoining properties and may have been transported off the site via subsurface migration. Additionally, analysis of samples from access points in the residence sewer system effluent established that the system was contaminated. 3 refs., 26 figs., 13 tabs.

  14. The three avenues of gerontology: from basic research to clinical gerontology and anti-aging medicine. Another French paradox.

    PubMed

    Robert, Leslie

    2004-06-01

    This is a contribution to the debate raised by the position statement on aging ( 1) and comments ( 2) concerning the rapid increase of anti-aging medicine. After a short summary of the history of social attitude to aging and the emergence of experimental gerontology, the French situation is described, emphasizing the economic basis of this phenomenon: increasing insurance fees and tightly controlled honoraria push an increasing number of physicians to this new discipline. No lack of communication seems to be involved between basic gerontologists and physicians ( 2). Anti-aging medicine profits of the increasing population of seniors who want to remain healthy, look young and dislike to consult geriatricians. And also of the fact that no over-the-counter delivery of drugs is available in France. For these reasons there is no serious hope to stop it otherwise than by state legislation. PMID:15215259

  15. Constraints, synergies and avenues for scaling up breastfeeding, antibiotics for pneumonia and IMCI interventions in the Cusco region, Peru

    PubMed Central

    Gericke, Christian A

    2012-01-01

    Objective: The purpose of this qualitative case study was to assess the feasibility of scaling up exclusive breastfeeding for 6 months, antibiotics for pneumonia and integrated management of childhood illness (IMCI) child interventions in three districts of the Cusco region, Peru. Methods: During field visits, constraints, synergies and solutions to the implementation of the selected interventions were collected through observational recording and interviews of mothers, health workers, and health managers/decision makers. Results are presented for each intervention according to the health system level where they occurred: mother/community, health worker, health centre, and political/managerial levels. Findings: This case study demonstrates that it is feasible to scale up exclusive breastfeeding, antibiotics for pneumonia and IMCI interventions in poverty-stricken rural areas of a low-income country. Factors that helped and hindered the implementation were identified for each intervention. Conclusions: The need for a coherent multi-sector approach that includes regulation, implementation and monitoring of health policies and education of all involved stakeholders was apparent. This study also demonstrates that global health interventions need to undergo local adaptation. Identifying local constraints and facilitating factors in a systematic way as proposed in this study is a useful step to increase their effectiveness and reach at the local level and to identify areas for improvement in the original intervention policies. PMID:24358831

  16. Providing an Avenue for Individual Enhancement: The Challenge for Vocational-Technical Education and Training in Nigeria.

    ERIC Educational Resources Information Center

    Khaleel, Ibrahim Adamu

    Nigeria's social and economic conditions at and after independence necessitated changes in educational and employment policy. At independence, in 1960, unification and economic development were necessary to galvanize the country's direction. Control and domination of the economy by foreigners deprived the country of the development of an…

  17. Radiological assessment report for the University of Rochester Annex, 400 Elmwood Avenue, Rochester, New York, April-May 1984

    SciTech Connect

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Flynn, K.F.

    1984-12-01

    In light of the results of the comprehensive radiological assessment of the annex and auxiliary facilities, the following conclusions can be made: There is no immediate hazard from the elevated levels of radioactivity detected; however, some of these levels are above criteria. The radon, thoron, actinon, long-lived particulates, and tritium in the air are all below criteria for unrestricted use. Some ductwork has been identified as being contaminated. All ductwork must, therefore, be considered potentially contaminated. Since several floor drains were found to exhibit elevated readings, and the samples had elevated concentrations of radionuclides, it must be concluded that the drain and sewer systems of the Annex are contaminated with radioactive material. Since the samples collected from the storm and sewer systems outside the building also had elevated concentrations of radionuclides, these systems are also considered contaminated with radioactive material. The grounds around the Annex have exhibited background concentrations of radionuclides. Two rooms, B-330 and B-332, were inaccessible for survey due to the presence of stored furniture and equipment. Therefore, no comment about their radiological status can be made. At the common baseboard for Room C-12 and C-16 and on the floor below the tile in Room C-40, contamination appeared to be masked by construction modifications. Other areas of the Annex must also be considered potentially contaminated where modifications may have masked the contamination.

  18. Cave levels of Trenton-Black River in south-central Michigan

    SciTech Connect

    De Haas, R.J.; Jones, M.W.

    1984-12-01

    Four generalized cave levels of the Trenton-Black River in south-central Michigan are most notable because of lost circulation zones in productive field areas. The uppermost cave level extends about 250 ft (76 m) into the Trenton. It is best developed in the widest, most productive areas of Albion-Scipio, where the drill bit dropped as much as 62 ft (19 m). About 59 productive wells in Albion-Scipio lost circulation at this level. The upper middle level includes the lower, slightly argillaceous Trenton, and the uppermost Black River formation. This level is developed to some extent in all fields, and is a common zone of solution-collapse brecciation. Because this level is collapsed, lost circulation is less common. The lower middle level below the Black River shale is not penetrated by many wells in Albion-Scipio. Where penetrated, it is developed in all fields, and is the main producer in most smaller fields. About 26 wells in Albion-Scipio lost circulation at this level, with the drill bit dropping as much as 80 ft (24 m). The lowermost cave level extends into the Glenwood Shale. It is the most widely developed level, but is intersected by few productive holes. Only seven wells lost circulation at this level in Albion-Scipio, but the drill bit has dropped as much as 8 ft (2.4 m) in the Glenwood. This cave level effectively drained some oil from reservoirs where the oil-water contact intersects the Glenwood.

  19. 7 CFR 29.3061 - Strength (tensile).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS TOBACCO INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3061 Strength (tensile). The stress a tobacco leaf can bear without tearing....

  20. 7 CFR 29.3061 - Strength (tensile).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATIONS TOBACCO INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3061 Strength (tensile). The stress a tobacco leaf can bear without tearing....

  1. 7 CFR 29.3061 - Strength (tensile).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATIONS TOBACCO INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3061 Strength (tensile). The stress a tobacco leaf can bear without tearing....

  2. 7 CFR 29.3061 - Strength (tensile).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATIONS TOBACCO INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3061 Strength (tensile). The stress a tobacco leaf can bear without tearing....

  3. 7 CFR 29.3032 - Injury.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3032..., insects, or weather conditions; insecticides, fungicides, or cell growth inhibitors;...

  4. 7 CFR 29.3032 - Injury.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3032..., insects, or weather conditions; insecticides, fungicides, or cell growth inhibitors;...

  5. 7 CFR 29.3032 - Injury.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3032..., insects, or weather conditions; insecticides, fungicides, or cell growth inhibitors;...

  6. 7 CFR 29.3032 - Injury.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... INSPECTION Standards Official Standard Grades for Burley Tobacco (u.s. Type 31 and Foreign Type 93) § 29.3032..., insects, or weather conditions; insecticides, fungicides, or cell growth inhibitors;...

  7. 7 CFR 29.401 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... or burley tobacco. (n) Pesticide. Any substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest, and any substance or mixture of substances intended for use...

  8. 7 CFR 29.401 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... a plant regulator, defoliant, or desiccant. (o) Pesticide certification. A document issued by the... or burley tobacco. (n) Pesticide. Any substance or mixture of substances intended for preventing... any banned pesticide. (p) Prohibited pesticide residue. The maximum concentration of residue...

  9. To designate the United States courthouse located at 222 West 7th Avenue in Anchorage, Alaska, as the "James M. Fitzgerald United States Courthouse".

    THOMAS, 112th Congress

    Rep. Young, Don [R-AK-At Large

    2011-10-13

    10/14/2011 Referred to the Subcommittee on Economic Development, Public Buildings and Emergency Management. (All Actions) Notes: For further action, see S.1710, which became Public Law 112-101 on 3/14/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  10. New avenue in the treatment of temporal lobe epilepsy by classical anti-epileptics: A hypothetical establishment of executioner Caspase 3 inactivation by molecular modeling

    PubMed Central

    Aanandhi, M. Vijey; Bhattacherjee, Debojit; Ray, Anirban; George, P. Samuel Gideon

    2015-01-01

    Patients with temporal lobe epilepsy (TLE) are prescribed first-line antiepileptic drugs and surgery to the management of this disorder. Unfortunately, the surgical treatment has been shown to be beneficial for the selected patients but fails to provide a seizure-free outcome in 20–30% of TLE patients. In our present study, we investigate the possibilities of marketed antiepileptic drugs in a different manner to improve the present situation in TLE. Molecular docking simulation study and various open source computational tools were used to perform the study. AutoDock 4.2 MGL tools, Pymol visualize tools, Patch dock server, and Swarm Dock servers (protein-protein docking) were used to perform the molecular modeling. FTsite and computed atlas of surface topography of protein open source server were used to understand the pocket and ligand binding information respectively. Toxtree application was used to determine the toxicity profile of the drug by Cramers rule. The obtained molecular docking models (Caspase 3, Procaspase 8, and Fas-associated death domain [FADD]) with selected compounds (Clonazepam, Clobazepam, and Retigabine) showed promising trio blocking event of FADD, Caspase 3, and Procaspase 8 (−6.66 kcal, −8.1 kcal, 6.46 kcal) by Clonazepam respectively. Protein-protein interaction study (Swarm Dock, Patch Dock server) indicated promising results that helped to establish our hypothesis. Toxtree showed a quantitative structure toxicity relationship report that helps to clarify the toxicity of the selected compounds. Clonazepam showed a trio inhibition property that may lead to develop a new era of the new generation benzodiazepine prototype drugs in the future. Filtered compounds will further process for higher in vitro, in vivo models for better understanding of the mechanism. PMID:25878976

  11. New avenues for ligand-mediated processes--expanding metal reactivity by the use of redox-active catechol, o-aminophenol and o-phenylenediamine ligands.

    PubMed

    Broere, Daniël L J; Plessius, Raoul; van der Vlugt, Jarl Ivar

    2015-10-01

    Redox-active ligands have evolved from being considered spectroscopic curiosities - creating ambiguity about formal oxidation states in metal complexes - to versatile and useful tools to expand on the reactivity of (transition) metals or to even go beyond what is generally perceived possible. This review focusses on metal complexes containing either catechol, o-aminophenol or o-phenylenediamine type ligands. These ligands have opened up a new area of chemistry for metals across the periodic table. The portfolio of ligand-based reactivity invoked by these redox-active entities will be discussed. This ranges from facilitating oxidative additions upon d(0) metals or cross coupling reactions with cobalt(iii) without metal oxidation state changes - by functioning as an electron reservoir - to intramolecular ligand-to-substrate single-electron transfer to create a reactive substrate-centered radical on a Pd(ii) platform. Although the current state-of-art research primarily consists of stoichiometric and exploratory reactions, several notable reports of catalysis facilitated by the redox-activity of the ligand will also be discussed. In conclusion, redox-active ligands containing catechol, o-aminophenol or o-phenylenediamine moieties show great potential to be exploited as reversible electron reservoirs, donating or accepting electrons to activate substrates and metal centers and to enable new reactivity with both early and late transition as well as main group metals. PMID:26148803

  12. Global calcium transducer P-type Ca²⁺-ATPases open new avenues for agriculture by regulating stress signalling.

    PubMed

    Huda, Kazi Md Kamrul; Banu, Mst Sufara Akhter; Tuteja, Renu; Tuteja, Narendra

    2013-08-01

    Food security is in danger under the continuous growing threat of various stresses including climate change and global warming, which ultimately leads to a reduction in crop yields. Calcium plays a very important role in many signal transduction pathways including stress signalling. Different extracellular stimuli trigger increases in cytosolic calcium, which is detrimental to plants. To cope with such stresses, plants need to develop efficient efflux mechanisms to maintain ionic homeostasis. The Ca(2+)-ATPases are members of the P-type ATPase superfamily, which perform many fundamental processes in organisms by actively transporting ions across cellular membranes. In recent years, many studies have revealed that, as well as efflux mechanisms, Ca(2+)-ATPases also play critical roles in sensing calcium fluctuations and relaying downstream signals by activating definitive targets, thus modulating corresponding metabolic pathways. As calcium-activated calmodulin (CaM) is reported to play vital roles in stress tolerance, the presence of a unique CaM-binding site in type IIB Ca(2+)-ATPases indicates their potential role in biotic as well as abiotic stress tolerance. The key roles of Ca(2+)-ATPases in transport systems and stress signalling in cellular homeostasis are addressed in this review. A complete understanding of plant defence mechanisms under stress will allow bioengineering of improved crop plants, which will be crucial for food security currently observed worldwide in the context of global climate changes. Overall, this article covers classification, evolution, structural aspects of Ca(2+)-ATPases, and their emerging roles in plant stress signalling.

  13. Avenues of Entry into the World of Western Art Music: Exposing Students to Western Art Music Informally Is One Way to Promote Appreciation for This Music

    ERIC Educational Resources Information Center

    Szabo, Moira

    2005-01-01

    Throughout the author's teaching career of the last thirty years, he has thought a great deal about how to prepare children for meaningful encounters with Western art music, a type of music that is not normally a part of their listening environments. (Many young people consider it music of the grey-haired generation.) The Western art music he was…

  14. Gender Differences in Expressed Interests in Engineering-Related Fields ACT 30-Year Data Analysis Identified Trends and Suggested Avenues to Reverse Trends

    ERIC Educational Resources Information Center

    Iskander, E. Tiffany; Gore, Paul A., Jr.; Furse, Cynthia; Bergerson, Amy

    2013-01-01

    Historically, women have been underrepresented in the Science, Technology, Engineering, and Math (STEM) fields both as college majors and in the professional community. This disturbing trend, observed in many countries, is more serious and evident in American universities and is reflected in the U.S. workforce statistics. In this article, we…

  15. Maywood Interim Storage Site environmental report for calendar year 1992, 100 West Hunter Avenue, Maywood, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Maywood Interim Storage Site (MISS) and provides the results for 1992. Environmental monitoring of MISS began in 1984, when the site was assigned to DOE by Congress through the Energy and Water Development Appropriations Act and was placed under DOE`s Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. MISS is part of a National Priorities List (NPL) site. The environmental surveillance program at MISS includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-232, and total uranium in surface water, sediment, and groundwater. Additionally, chemical analysis includes metals and organic compounds in surface water and groundwater and metals in sediments. This program assists in fulfilling the DOE objective of measuring and monitoring effluents from DOE activities and calculating hypothetical doses to members of the general public. Monitoring results are compared with applicable Environmental Protection Agency (EPA) and state standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements. Environmental standards are established to protect public health and the environment. The radiological data for all media sampled support the conclusion that doses to the public are not distinguishable from natural background radiation.

  16. Superfund Record of Decision (EPA Region 2): Nascolite Corporation, Doris Avenue, cities of Millville and Vineland, Cumberland County, NJ. (Second remedial action), June 1991. Final report

    SciTech Connect

    Not Available

    1991-06-28

    The 17.5-acre Nascolite site is an inactive acrylic and plexiglass sheet manufacturing plant in Millville, Cumberland County, New Jersey. The site lies within the New Jersey coastal plain and overlies clay, silt, sand, and gravel layers. The majority of the site is wooded, with a wetland located in the southwestern portion. In 1980, although the State ordered the plant to stop discharging wastewaters into the onsite drainage ditch, well water monitoring conducted during 1981 identified VOC-contamination in these wells. In 1984, the State identified over one hundred 55-gallon drums and several underground storage tanks buried onsite. In 1987, the State ordered Nascolite to remove some of the drums, and later during 1987 and 1988, EPA removed the remaining drums offsite. The ROD addresses contaminated onsite soil, sediment, and buildings. The primary contaminant of concern affecting the soil, sediment, and debris is the inorganic contaminant lead; and VOCs including benzene, PCE, TCE, toluene, and xylenes. The selected remedial action for the site is included.

  17. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy.

    PubMed

    Daughton, Christian G

    2003-05-01

    Since the 1980s, the occurrence of pharmaceuticals and personal care products (PPCPs) as trace environmental pollutants, originating primarily from consumer use and actions rather than manufacturer effluents, continues to become more firmly established. Although PPCPs typically have been identified in surface and ground waters, some are also undoubtedly associated with solid phases such as suspended particulates, sediments, and sewage sludges, despite their relatively high affinity for water. Often amenable to degradation, their continual introduction to waste-receiving waters results from their widespread, continuous, combined use by individuals and domestic animals, giving PPCPs a "pseudo-persistence" in the environment. Little is known about the environmental or human health hazards that might be posed by chronic, subtherapeutic levels of these bioactive substances or their transformation products. The continually growing, worldwide importance of freshwater resources, however, underscores the need for ensuring that any aggregate or cumulative impacts on (or from) water supplies are minimized. Despite the paucity of effects data from long-term, simultaneous exposure at low doses to multiple xenobiotics (particularly non-target-organism exposure to PPCPs), a wide range of proactive actions could be implemented to reduce or minimize the introduction of PPCPs to the environment. Most of these actions fall under what could be envisioned as a holistic stewardship program--overseen by the health care industry and consumers alike. Significantly, such a stewardship program would benefit not just the environment; additional, collateral benefits could automatically accrue, including reducing consumers' medication expenses and improving patient health and consumer safety. In this article, the first of a two-part mini-monograph describing the "green pharmacy," I focus initially on the background behind the imperative for an ecologically oriented stewardship program for PPCPs. I then present a broad spectrum of possible source control/reduction actions, controlled largely by the health care industry, that could minimize the disposition of PPCPs to the environment. This two-part mini-monograph attempts to capture cohesively for the first time the wide spectrum of actions available for minimizing the release of PPCPs to the environment. A major objective is to generate an active dialog or debate across the many disciplines that must become actively involved to design and implement a successful approach to life-cycle stewardship of PPCPs.

  18. Colonie Interim Storage Site environmental report for calendar year 1992, 1130 Central Avenue, Colonie, New York. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Colonie Interim Storage Site (CISS) and provides the results for 1992. The site is located in eastern New York State, approximately 6.4 km (4.0 mi) northwest of downtown Albany. From 1958 to 1984, National Lead (NL) Industries used the facility to manufacture various components from depleted and enriched uranium natural thorium. Environmental monitoring of CISS began in 1984 when Congress added, the site to the US Department of Energy`s (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP is a program established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. The environmental surveillance program at CISS includes sampling networks for external gamma radiation exposure and for thorium-232 and total uranium concentrations in surface water, sediment, and groundwater. Several chemical parameters are also measured in groundwater, including total metals, volatile organics, and water quality parameters. This surveillance program assists in fulfilling the DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses. Results are compared with applicable Environmental Protection Agency (EPA) and New York State Department of Environmental Conservation (NYSDEC) standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements.

  19. Cost-effective bifacial dye-sensitized solar cells with transparent iron selenide counter electrodes. An avenue of enhancing rear-side electricity generation capability

    NASA Astrophysics Data System (ADS)

    Liu, Juan; Tang, Qunwei; He, Benlin; Yu, Liangmin

    2015-02-01

    Alloy materials have established themselves as alternative electrocatalysts for electrochemical devices because of their cost-effectiveness, high conductivity, good electrocatalytic activity, and reasonable stability. Aiming at reducing fabrication cost without sacrificing power conversion efficiency of dye-sensitized solar cells (DSSCs), we report the feasibility of designing transparent and cost-effective Fe-Se alloy counter electrodes for bifacial DSSCs. Due to the rapid charge transfer ability and electrocatalytic activity, maximum front and rear efficiencies of 7.64% and 4.95% are measured for the DSSC with FeSe alloy electrode in comparison with 6.97% and 3.56% from Pt-based solar cell. The impressive results along with simple synthesis highlight the potential application of Fe-Se alloys in robust bifacial DSSCs.

  20. In-flight verification of avalanche photodiodes: avenue to a low-cost solution to measure suprathermal particles for future missions

    NASA Astrophysics Data System (ADS)

    Ogasawara, K.; Bonnell, J. W.; Christian, E. R.; Desai, M. I.; Grubbs, G. A., II; Jahn, J. M.; Livi, S. A.; Kanekal, S. G.; Llera, K.; McComas, D. J.; Michell, R.; Samara, M.; Vines, S. K.

    2014-12-01

    Flight operation results and plans of Avalanche Photodiodes (APDs) to measure suprathermal particles (a ~few keV up to ~100s of keV) are summarized in this presentation. Ions and electrons in this energy range play crucial roles in many fundamental processes of space plasmas including particle heating and acceleration, providing source material for the energetic particles accelerated near the Sun, the heliosphere, and in geospace. Characterizing these populations poses serious technical challenges because this energy region lies between the two most commonly used particle detection techniques, i.e., that used by thermal or plasma instruments and by Solid-State Detector (SSD)-based energetic particle telescopes, which are limited by typical SSD threshold energies of >10s keV. Our previous work has already demonstrated that a new type of low-noise, low-threshold Avalanche Photo-Diode (APD) has an intrinsic noise level of 0.9 keV, and can therefore enable high-energy resolution measurements of suprathermal electrons and ions. In addition, APDs provide suitable solutions for space plasma detectors in low-cost missions/platform because of their light-weight, small-size, power-saving features. This study presents two low-cost missions (a sounding rocket and a CubeSat) that implement APDs as particle detectors: (1) The Medium-energy Electron SPectrometer (MESP) sensor aboard a sounding rocket was launched from Poker Flat Research Range on 3 March 2014 as a part of Ground-to-Rocket Electrodynamics-Electrons Correlative Experiment (GREECE) mission. MESP successfully measured the precipitating electrons from 2 to 200 keV in 100-ms time resolution by using 2 APDs and 1 SSD. We show the overall results and the comparison with an MCP-based instrument results. (2) The Miniaturized Electron and pRoton Telescope (MERiT) on the Compact Radiation bElt Explorer (CeREs) to study charged particle dynamics in the Earth's radiation belts. CeREs will be flown as part of a 3U CubeSat in a high-inclination low-Earth orbit in 2015. MERiT is designed to measure suprathermal to relativistic electrons from ~5 keV up to10 MeV, and 4 APDs will be applied to cover the lower portion of the energy range. Along with the calibration efforts, we will present predicted in-orbit performances of these APD detectors in the CeREs mission.