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Sample records for albion avenue burley

  1. 7. VIEW SHOWING SOUTH SIDE OF BURLEY SUBSTATION WITH DRYCLEANERS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW SHOWING SOUTH SIDE OF BURLEY SUBSTATION WITH DRYCLEANERS IN FOREGROUND AND SIDE OF SUBSTATION WITH BREAK BETWEEN 1913-1914 AND 1921 CONSTRUCTION PHASES IN BACKGROUND - Bonneville Power Administration Burley Substation, 1221 Albion Avenue, Burley, Cassia County, ID

  2. 11. INTERIOR VIEW OF BURLEY SUBSTATION, SECOND STORY, LOOKING EAST, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. INTERIOR VIEW OF BURLEY SUBSTATION, SECOND STORY, LOOKING EAST, SHOWING PARTITIONS, POURED-IN-PLACE CONCRETE ROOF AND WATER- DAMAGED SOUTH WALL (BREAK BETWEEN 1913-1914 AND 1921 CONSTRUCTION PHASES IN FOREGROUND) - Bonneville Power Administration Burley Substation, 1221 Albion Avenue, Burley, Cassia County, ID

  3. 3. VIEW SHOWING FRONT HALF OF NORTH SIDE OF BURLEY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW SHOWING FRONT HALF OF NORTH SIDE OF BURLEY SUBSTATION, LOOKING SOUTHWEST. BREAK BETWEEN 1913-1914 AND 1921 CONSTRUCTION PHASES, LOCATED BELOW AND ABOVE RIGHT EDGE OF SECOND WINDOW, FRONT LEFT OF PHOTOGRAPH - Bonneville Power Administration Burley Substation, 1221 Albion Avenue, Burley, Cassia County, ID

  4. 33 CFR 80.1146 - Albion River, CA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Albion River, CA. 80.1146 Section 80.1146 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1146 Albion River, CA. A line drawn on an...

  5. The Albion Street Centre database, Sydney, Australia.

    PubMed

    Gold, J

    1998-01-01

    The Albion Street Centre was established in 1985 as an HIV testing and early management center. More than 22,000 people have been screened for HIV and other blood-borne infections at the Centre, and approximately 3,600 people with HIV/AIDS have been managed there. Approximately 1,600 patients with various stages of HIV disease are currently managed at the Centre by a staff of 60 health care professionals and about 1,000 volunteers. The Albion Street Centre's computer database began recording selected demographic, epidemiologic, clinical, and laboratory characteristics when the first patient presented in 1985. Since then, the complexity and utilization of the database has increased in parallel with improvement in the understanding of the natural history and pathogenesis of HIV infection. Over 100 peer-reviewed publications and presentations have been produced from the database and 45 clinical trials have used the database to identify potential subjects. All data are de-identified and are protected by multiple password codes. Approximately 700 variables are collected from each HIV-positive patient at the initial visit to the Centre and up to 200 variables are added at each subsequent routine clinic visit. The variables collected include the following: standard epidemiologic characteristics; transmission and behavioral parameters, clinical signs and symptoms; laboratory test results; treatments; nutritional history; body composition parameters; psychological assessment results; and management history, including neuropsychological testing. The overall number and characteristics of patients recorded in the database are reported monthly, and are used to plan services, for prevention and educational programs, and as an indicator of the effectiveness of campaigns to encourage HIV-positive people to attend clinics for early management. When these patients have been identified they are invited to participate in the study. Individual patient records are identified and

  6. Health assessment for Albion-Sheridan Township Landfill, Albion, Calhoun County, Michigan, Region 5. CERCLIS No. MID980504450. Preliminary report

    SciTech Connect

    Not Available

    1990-09-10

    The Albion-Sheridan Township Landfill is on the United States Environmental Protection Agency (EPA) National Priorities List (NPL). The Albion-Sheridan Township Landfill is an inactive landfill covering 30 acres located 1 mile east of the City of Albion. Prior to 1966, the site was an uncontrolled dump. From 1966 through 1981, the privately owned, State-permitted landfill accepted municipal refuse and industrial wastes from Albion and nearby Sheridan Township. In 1980, groundwater samples taken from three on-site monitoring wells were found to be contaminated with iron, sodium, potassium, lead, magnesium, calcium, ammonia, total chromium, copper, and zinc. These monitoring wells draw water from the upper aquifer. Soil boring samples taken at the same time revealed the presence of nickel, lead, cyanide, cadmium, chromium, copper, zinc, and iron. Sludge samples taken in 1984 and 1986 contained concentrations of nickel, lead, chloride and cyanide, chromium, and cadmium. The recent preliminary investigation of the on-site barrel contents have tentatively identified potentially flammable hazardous wastes and a variety of VOC's. Based upon information reviewed, this site is of potential public health concern because of possible exposure to hazardous substances at concentrations that may result in adverse health effects. As noted above, human exposure to various contaminants may have occurred or may occur in the future via direct contact, ingestion, and inhalation of contaminants.

  7. Leadership, Engagement, and the Small Liberal Arts College: Albion College and the Smart Community.

    ERIC Educational Resources Information Center

    Mitchell, Peter T.; Levine, Myron A.

    2001-01-01

    Describes the development of a new transformational vision for Albion College in Michigan, which led to a community envisioning process off campus. The result was a new city-college partnership designed to promote the development of the city of Albion as "The Smart Community." (EV)

  8. Results from the UK 3rd generation programme: Albion

    NASA Astrophysics Data System (ADS)

    McEwen, R. K.; Axcell, C.; Knowles, P.; Hoade, K. P.; Wilson, M.; Dennis, P. N. J.; Backhouse, P.; Gordon, N. T.

    2008-10-01

    Following the development of 1st Generation systems in the 1970s, thermal imaging has been in service with the UK armed forces for over 25 years and has proven itself to be a battle winning technology. More recently the wider accessibility to similar technologies within opposing forces has reduced the military advantage provided by these 1st Generation systems and a clear requirement has been identified by the UK MOD for thermal imaging sensors providing increased detection, recognition and identification (DRI) ranges together with a simplified logistical deployment burden and reduced through-life costs. In late 2005, the UK MOD initiated a programme known as "Albion" to develop high performance 3rd Generation single waveband infrared detectors to meet this requirement. At the same time, under a separate programme supporting higher risk technology, a dual waveband infrared detector was also developed. The development phase of the Albion programme has now been completed and prototype detectors are now available and have been integrated into demonstration thermal imaging cameras. The Albion programme has now progressed into the second phase, incorporating both single and dual waveband devices, focussing on low rate initial production (LRIP) and qualification of the devices for military applications. All of the detectors have been fabricated using cadmium mercury telluride material (CMT), grown by metal organic vapour phase epitaxy (MOVPE) on low cost, gallium arsenide (GaAs) substrates and bump bonded to the silicon read out circuit (ROIC). This paper discusses the design features of the 3rd Generation detectors developed in the UK together with the results obtained from the prototype devices both in the laboratory and when integrated into field deployable thermal imaging cameras.

  9. 3. Photocopy of photograph ('Town and Community Planning, Walter Burley ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of photograph ('Town and Community Planning, Walter Burley Griffin,' Western Architect, Vol. 19, No. 8, August, 1913, following page 80) ca 1913 MAIN FACADE AND GARAGE FACADE - Arthur L. Rule House, 11 South Rock Glen, Mason City, Cerro Gordo County, IA

  10. Preliminary Observations on Drusy Vugs in the Albion Iron Meteorite

    NASA Astrophysics Data System (ADS)

    Marvin, U. B.; Petaev, M. I.; Kempton, R.

    1996-03-01

    A 22.28-kg mass of iron, found in Albion, Washington, in the winter of 1966-1967 remained unknown until 1991 when the finder brought it to Carleton B. Moore at Arizona State University. Moore identified it as a meteorite and sent a sample to John A. Wasson at UCLA who classified it as a IVA fine octahedrite. This iron is unique in having vugs, ranging in length from 4 to 9 mm, scattered throughout the otherwise orderly Widmanstatten structure. Drusy spheroids cover the walls and partially fill some of the vugs. We have analyzed the constituents of one vug (Vug-A) and the metals surrounding it. The drusy spheroids consist mainly of small, irregular grains of kamacite containing 2-3.5 wt.% Ni and several rounded masses of tetrataenite (55.6 wt.% Ni). Both metals are enmeshed in troilite which appears to have invaded and corroded them. Daubreelite (FeCr2S4) in euhedral grains is scattered through the spheroids and elsewhere in the iron. It formed earlier than the troilite which contains no chromium and shows no sign of reaction where the two are in contact. A phosphide mineral in euhedral to subhedral grains, 3-15 um across, also occurs in the spheroids. Our analyses of sixteen grains yielded a consistent composition of [Ni 0.54 (Fe 0.46)3.7 P], which we are examining as a new species. The spheroids are rimmed with kamacite and show clear evidence of having grown in stages during the passage of a fluid or vapor phase. We regard the vugs as primary features inherited from bubbles in the cooling melt that remained open during formation of the Widmanstatten structures. Previous investigators have attributed masses of troilite-kamacite intergrowths to shock-melting of troilite nodules. However, we find it difficult to envision shock processes opening cavities, lining them with drusy minerals, and giving rise to a new phosphide without damaging the metal in which we find no evidence of shock effects. We are investigating further our hypothesis that the unique vugs in the

  11. Pathophysiology of the thalassemias. The Albion Walter Hewlett Award presentation.

    PubMed Central

    Schrier, S L

    1997-01-01

    The Albion Walter Hewlett Award (named for Professor of Medicine and Chair of the Stanford Department of Medicine 1916-1925) recognizes a role model, accomplished in discovery of the biological sciences and at the same time a consummate and compassionate physician. In introductory remarks, Dr. Stanley L. Schrier, Professor of Medicine (Hematology), the tenth recipient of the Award, indicated that the person so identified is no longer a viable model in academic medicine. The loss of this sort of person is serious because this appropriately trained physician-investigator was uniquely positioned to study pathophysiology, defined as the processes by which disordered biology produces disease. He used his own studies on the clinical manifestations of the thalassemias to clarify what he meant by pathophysiology. Thus he and his colleagues first defined membrane material properties of alpha and beta thalassemic RBC membranes and the states of hydration of alpha and beta thalassemic RBC and found them to be strikingly divergent. The biochemical counterparts of these alterations proved to be the accumulation of the excess unmatched partially oxidized globin chains on the membrane skeleton. In vitro studies with chemical oxidants selectively oxidized alpha and beta globin chains which then attached to the RBC membrane skeleton and reproduced the membrane material properties characteristic of beta and alpha thalassemia respectively. Many of these alterations had occurred prior to the reticulocyte stage so that pursuit of pathophysiology shifted to studies of marrow erythroid precursors, and it was shown that in beta thalassemia major there was accelerated programmed cell death as well as defective assembly of the membrane skeleton. Images Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Figure 8. PMID:9291745

  12. 7 CFR 29.75a - Display of burley tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Display of burley tobacco on auction warehouse floors... § 29.75a Display of burley tobacco on auction warehouse floors in designated markets. (a)(1) Each lot of burley tobacco displayed for sale on auction warehouse floors shall have a minimum space of...

  13. Summary of Hydrologic and Geochemical Investigations of the Albion Basin, Little Cottonwood Canyon, Alta, Utah

    NASA Astrophysics Data System (ADS)

    Skalbeck, J.; Clancy, J.; Kraus, J.

    2013-12-01

    This hydrologic and geochemical investigation of the Albion Basin was initiated in August 2005 as a background study that included reviewing existing reports, publications, maps, and other available data and preparing a phased research plan. Annual field investigations have continued with the goal to evaluate watershed characteristics of the Albion Basin and provide scientific information that can be used in watershed management decisions. In August 2006, ten piezometers were installed in the Albion Basin for water level and water chemistry monitoring at three wetland areas (Albion Basin Fen, Catherine's Pass, and Collins/Sugarloaf) and in the streambed of Little Cottonwood Creek. In August 2012, a single piezometer was installed in the Patsy Marley wetland area. The August 2013 field season represents the 8th monitoring period for this investigation. Annual monitoring consists of collecting: (1) automated water levels using pressure transducers, (2) manual water levels using an electronic sounder, (3) field water parametes (temperature, pH, electrical conductivity), and (4) water samples for laboratory chemical analysis of major cations and anions. Water samples have been collected from piezometers, springs, and surface water to characterize the potential source water for the wetland areas. In 2011 and 2012, snow samples were collected for laboratory chemical analysis to characterize the water chemistry from precipitation. A reconnaissance survey of springs located in each of the wetland areas within the basin was performed during the August 2013 record general vegetation and rock type, water field water parameter measurements, and relative flow characteristics. The goal is to assess the contribution of source water for each of the wetland areas and to identify water source areas and flow paths within the basin. In general the water sample results represent calcium, magnesium bicarbonate fresh water. These results, along with the snow sample results, provide for

  14. Celebrating 130 Years of the Alvan Clark Telescope at Albion College

    NASA Astrophysics Data System (ADS)

    Zellner, Nicolle; Smeltekop, N. Garrett

    2014-01-01

    This year, 2013-2014, marks the 130th anniversary of the 8” Alvan Clark refracting telescope and observatory building at Albion College, an undergraduate college in Albion, MI. Completed in 1884, the observatory is an excellent example of a nineteenth century astronomical building; its telescope is still useable and other instruments (Fauth and Company sidereal clock, transit telescope, and chronograph) are in very good condition. The building has a long history, serving once as a barracks for World War I soldiers, and the telescope has helped to train the next generation of scientists, from Forest Ray Moulton (Class of 1894) to present-day students. Several times each year, the telescope is open to the public and to the campus community for public observing events, and during the anniversary year, several other activities are planned. I will describe the history of our observatory and its people and give an overview of the events planned for this year.

  15. 7 CFR 29.75a - Display of burley tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Display of burley tobacco on auction warehouse floors... COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS TOBACCO INSPECTION Regulations Mandatory Inspection § 29.75a Display of burley tobacco on auction warehouse floors in designated markets. (a)(1) Each...

  16. 7 CFR 29.75a - Display of burley tobacco on auction warehouse floors in designated markets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Display of burley tobacco on auction warehouse floors... COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS TOBACCO INSPECTION Regulations Mandatory Inspection § 29.75a Display of burley tobacco on auction warehouse floors in designated markets. (a)(1) Each...

  17. 5. VIEW FROM MERRITTS AVENUE LOOKING SOUTHWEST ACROSS TECHWOOD AVENUE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW FROM MERRITTS AVENUE LOOKING SOUTHWEST ACROSS TECHWOOD AVENUE TOWARD 448-514 TECHWOOD AVENUE. - Techwood Homes (Public Housing), Bounded by North Avenue, Parker Street, William Street & Lovejoy Street, Atlanta, Fulton County, GA

  18. REPORT ON WASTE SOURCE MONITORING IN THE BURLEY, IDAHO AREA, 1974

    EPA Science Inventory

    At the request of EPA Region 10, NFIC-D conducted waste source monitoring in the Burley, Idaho area (17040209) from October 21-28, 1974 to provide an input to the water quality predictive mathematical model which covers the Milner Reservoir reach of the Snake River. Each waste s...

  19. VIEW OF PIEDMONT AVENUE AT INTERSECTION OF DURANT AVENUE WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT INTERSECTION OF DURANT AVENUE WITH DOME OF THE INTERNATIONAL HOUSE AT 2299 PIEDMONT AVENUE. BY GEORGE W. KELHAM, 1929, SEEN FROM SW CORNER LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  20. Avenue of approach generation

    SciTech Connect

    Powell, D.R.; Storm, G.

    1988-01-01

    Los Alamos National Laboratory is conducting research on developing a dynamic planning capability within an Army corps level combat simulation. Central to this research is the development of a computer based ability to ''understand'' terrain and how it is used in military planning. Such a capability demands data structures that adequately represent terrain features used in the planning process. These features primarily relate to attributes of mobility and visibility. Mobility concepts are abstracted to networks of mobility corridors. Notions of visibility are, for the purposes of planning, incorporated into the definition of key terrain. Prior work at Los Alamos has produced algorithms to generate mobility corridors from digitized terrain data. Mobility corridors, by definition, are the building blocks for avenues of approach, and the latter are the context in which key terrain is defined. The purpose of this paper is to describe recent work in constructing avenues of approach, characterization of avenues using summary characteristics, and their role in military planning. 7 refs., 4 figs., 1 tab.

  1. Albion: cost-effective 3rd generation high-performance thermal imaging in the UK

    NASA Astrophysics Data System (ADS)

    McEwen, R. K.; Lupton, M.; Lawrence, M.; Knowles, P.; Wilson, M.; Dennis, P. N. J.; Gordon, N. T.; Lees, D. J.; Parsons, J. F.

    2006-09-01

    The first generation of high performance thermal imaging sensors in the UK was based on two axis opto-mechanical scanning systems and small (4-16 element) arrays of the SPRITE detector, developed during the 1970s. Almost two decades later, a 2nd Generation system, STAIRS C was introduced, based on single axis scanning and a long linear array of approximately 3000 elements. This paper addresses the development of the UK's 3rd Generation High Performance Thermal Imaging sensor systems, under a programme known as "Albion". Three new high performance detectors, manufactured in cadmium mercury telluride, operating in both MWIR and LWIR, providing high resolution and sensitivities without need for opto-mechanical scanning systems will be described. The CMT material is grown by MOVPE on low cost substrates and bump bonded to the silicon read out circuit (ROIC). All three detectors are designed to fit with existing standard Integrated Detector Cooling Assemblies (IDCAs). The two largest detectors will be integrated with field demonstrator cameras providing MWIR and LWIR solutions that can rapidly be tailored to specific military requirements. The remaining detector will be a LWIR device with a smart ROIC, facilitating integration times much longer than can typically be achieved with focal plane arrays and consequently yield very high thermal sensitivity. This device will be demonstrated in a lab based camera system.

  2. Albion: the UK 3rd generation high-performance thermal imaging programme

    NASA Astrophysics Data System (ADS)

    McEwen, R. K.; Lupton, M.; Lawrence, M.; Knowles, P.; Wilson, M.; Dennis, P. N. J.; Gordon, N. T.; Lees, D. J.; Parsons, J. F.

    2007-04-01

    The first generation of high performance thermal imaging sensors in the UK was based on two axis opto-mechanical scanning systems and small (4-16 element) arrays of the SPRITE detector, developed during the 1970s. Almost two decades later, a 2nd Generation system, STAIRS C was introduced, based on single axis scanning and a long linear array of approximately 3000 elements. The UK has now begun the industrialisation of 3 rd Generation High Performance Thermal Imaging under a programme known as "Albion". Three new high performance cadmium mercury telluride arrays are being manufactured. The CMT material is grown by MOVPE on low cost substrates and bump bonded to the silicon read out circuit (ROIC). To maintain low production costs, all three detectors are designed to fit with existing standard Integrated Detector Cooling Assemblies (IDCAs). The two largest focal planes are conventional devices operating in the MWIR and LWIR spectral bands. A smaller format LWIR device is also described which has a smart ROIC, enabling much longer stare times than are feasible with conventional pixel circuits, thus achieving very high sensitivity. A new reference surface technology for thermal imaging sensors is described, based on Negative Luminescence (NL), which offers several advantages over conventional peltier references, improving the quality of the Non-Uniformity Correction (NUC) algorithms.

  3. VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. 2325 PIEDMONT (MRS. F.W. FISH HOUSE DESIGNED BY CHARLES S. KAISER, 1910. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  4. VIEW OF PIEDMONT AVENUE AT INTERSECTION OF DURANT AVENUE. SEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT INTERSECTION OF DURANT AVENUE. SEEN FROM NW CORNER LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  5. VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. Photograph by Brian Grogan, July 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  6. A Quantitative Real-Time PCR-Based Strategy for Molecular Evaluation of Nicotine Conversion in Burley Tobacco

    PubMed Central

    Sun, Bo; Xue, Sheng-Ling; Zhang, Fen; Luo, Zhao-Peng; Wu, Ming-Zhu; Chen, Qing; Tang, Hao-Ru; Lin, Fu-Cheng; Yang, Jun

    2015-01-01

    Nornicotine production in Nicotiana tabacum is undesirable because it is the precursor of the carcinogen N′-nitrosonornicotine. In some individual burley tobacco plants, a large proportion of the nicotine can be converted to nornicotine, and this process of nicotine conversion is mediated primarily by enzymatic N-demethylation of nicotine which is controlled mainly by CYP82E4. Here we report a novel strategy based on quantitative real-time polymerase chain reaction (qPCR) method, which analyzed the ratio of nicotine conversion through examining the transcript level of CYP82E4 in burley leaves and do not need ethylene induction before detected. The assay was linear in a range from 1 × 101 to 1 × 105 copies/mL of serially diluted standards, and also showed high specificity and reproducibility (93%–99%). To assess its applicability, 55 plants of burley cultivar Ky8959 at leaf maturing stage were analyzed, and the results were in accordance with those from gas chromatograph-mass spectrometry (GC-MS) method. Moreover, a linear correlation existed between conversion level and CYP82E4 transcript abundance. Taken together, the quantitative real-time PCR assay is standardized, rapid and reproducible for estimation of nicotine conversion level in vivo, which is expected to shed new light on monitoring of burley tobacco converter. PMID:26593897

  7. Determination of free amino acids in burley tobacco by high performance liquid chromatography

    PubMed Central

    Jing, Yanqiu; Zhang, Baolin; Yuan, Xiuxiu; Gao, Yuzhen; Lu, Ping; Wang, Weifeng; Xu, Min

    2015-01-01

    A reversed-phase high performance liquid chromatographic method was developed for determining free amino acids in burley tobacco. The test was done by OPA/3-mercaptopropionic acid as the pre-column derivatizing reagent. Chromatographic column was Elitte C18 column (4.6 mm × 250 mm i.d., 5 μm). Mobile phase A was 18 mol/l NaAc (pH7.2) including 0.002%(v/v) triethylamine and 0.3%(v/v) furanidine. Mobile phase B was 100 mol/l NaAc (pH7.2)–acetonitrile–methanol (v/v = 1:2:2). The column temperature was 40 °C and the flow rate was 1.0 ml/min. The fluorescence detector was used with 350 nm excitation wave length and 450 nm emission wave length. The average recoveries of the method ranged from 95.3–100.7% with the relative standard deviation of 2.32–9.24%. The method is simple, accurate and has good repeatability. The results of the determination of seventeen kinds of free amino acids in burley leaves were produced by the way of different ratios of cake fertilizer and inorganic fertilizer. The results show that Aspartic acid has the highest content however ratio of cake fertilizer and inorganic fertilizer. The contents of most of the free amino acids are increased and then gradually decreased with the increase in organic manure. The contents of most of the free amino acids are very close at 15:85% ratio and 30:70% ratio of cake fertilizer and inorganic fertilizer. The total amount of free amino acids is the highest at 30:70% ratio of cake fertilizer and inorganic fertilizer. Considering comprehensively, the quality of burley leaves is the best at 30:70% ratio of cake fertilizer and inorganic fertilizer. PMID:26858568

  8. Determination of free amino acids in burley tobacco by high performance liquid chromatography.

    PubMed

    Jing, Yanqiu; Zhang, Baolin; Yuan, Xiuxiu; Gao, Yuzhen; Lu, Ping; Wang, Weifeng; Xu, Min

    2016-01-01

    A reversed-phase high performance liquid chromatographic method was developed for determining free amino acids in burley tobacco. The test was done by OPA/3-mercaptopropionic acid as the pre-column derivatizing reagent. Chromatographic column was Elitte C(18) column (4.6 mm × 250 mm i.d., 5 μm). Mobile phase A was 18 mol/l NaAc (pH7.2) including 0.002%(v/v) triethylamine and 0.3%(v/v) furanidine. Mobile phase B was 100 mol/l NaAc (pH7.2)-acetonitrile-methanol (v/v = 1:2:2). The column temperature was 40 °C and the flow rate was 1.0 ml/min. The fluorescence detector was used with 350 nm excitation wave length and 450 nm emission wave length. The average recoveries of the method ranged from 95.3-100.7% with the relative standard deviation of 2.32-9.24%. The method is simple, accurate and has good repeatability. The results of the determination of seventeen kinds of free amino acids in burley leaves were produced by the way of different ratios of cake fertilizer and inorganic fertilizer. The results show that Aspartic acid has the highest content however ratio of cake fertilizer and inorganic fertilizer. The contents of most of the free amino acids are increased and then gradually decreased with the increase in organic manure. The contents of most of the free amino acids are very close at 15:85% ratio and 30:70% ratio of cake fertilizer and inorganic fertilizer. The total amount of free amino acids is the highest at 30:70% ratio of cake fertilizer and inorganic fertilizer. Considering comprehensively, the quality of burley leaves is the best at 30:70% ratio of cake fertilizer and inorganic fertilizer. PMID:26858568

  9. Syn-extensional plutonism and peak metamorphism in the albion-raft river-grouse creek metamorphic core complex

    USGS Publications Warehouse

    Strickland, A.; Miller, E.L.; Wooden, J.L.; Kozdon, R.; Valley, J.W.

    2011-01-01

    The Cassia plutonic complex (CPC) is a group of variably deformed, Oligocene granitic plutons exposed in the lower plate of the Albion-Raft River- Grouse Creek (ARG) metamorphic core complex of Idaho and Utah. The plutons range from granodiorite to garnet-bearing, leucogranite, and during intrusion, sillimanite- grade peak metamorphism and ductile attenuation occurred in the country rocks and normal-sense, amphibolite-grade deformation took place along the Middle Mountain shear zone. U-Pb zircon geochronology from three variably deformed plutons exposed in the lower plate of the ARG metamorphic core complex revealed that each zircon is comprised of inherited cores (dominantly late Archean) and Oligocene igneous overgrowths. Within each pluton, a spread of concordant ages from the Oligocene zircon overgrowths is interpreted as zircon recycling within a long-lived magmatic system. The plutons of the CPC have very low negative whole rock ??Nd values of -26 to -35, and initial Sr values of 0.714 to 0.718, consistent with an ancient, crustal source. Oxygen isotope ratios of the Oligocene zircon overgrowths from the CPC have an average ??18O value of 5.40 ?? 0.63 permil (2SD, n = 65) with a slight trend towards higher ??18O values through time. The ??18O values of the inherited cores of the zircons are more variable at 5.93 ?? 1.51 permil (2SD, n = 29). Therefore, we interpret the plutons of the CPC as derived, at least in part, from melting Archean crust based on the isotope geochemistry. In situ partial melting of the exposed Archean basement that was intruded by the Oligocene plutons of the CPC is excluded as the source for the CPC based on field relationships, age and geochemistry. Correlations between Ti and Hf concentrations in zircons from the CPC suggest that the magmatic system may have become hotter (higher Ti concentration in zircon) and less evolved (lower Hf in zircon concentration) through time. Therefore, the CPC represents prolonged or episodic magmatism

  10. 43. 253255 AUBURN AVENUE (Jim's Place; Unisex Beauty Shop) NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    43. 253-255 AUBURN AVENUE (Jim's Place; Unisex Beauty Shop) NORTH ELEVATION 44. --- PIEDMONT AVENUE (Pucker House) EAST ELEVATION - 126-255 Auburn Avenue (Commercial Buildings), Auburn Avenue, Atlanta, Fulton County, GA

  11. Contextual view along Blake Avenue showing north and west elevations; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view along Blake Avenue showing north and west elevations; camera facing southeast. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  12. Contextual view of building 253 looking down Walnut Avenue, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 253 looking down Walnut Avenue, showing south elevation at right; camera facing north. - Mare Island Naval Shipyard, Supply Building, Walnut Avenue, southeast corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  13. 2. HISTORIC PHOTOGRAPH OF CLINTON AVENUE BRIDGE, CA. 1940. COLLECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. HISTORIC PHOTOGRAPH OF CLINTON AVENUE BRIDGE, CA. 1940. COLLECTION CONNECTICUT DEPARTMENT OF TRANSPORTATION. - Merritt Parkway, Clinton Avenue/North Clinton Avenue Bridge, Spanning Merritt Parkway, Westport, Fairfield County, CT

  14. 23. General view of Second Avenue from Broadway looking toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. General view of Second Avenue from Broadway looking toward Church Street HABS TENN 19-NASH, 14-2 - Second Avenue North, Commercial District, Second Avenue North between Broadway & Church Streets, Nashville, Davidson County, TN

  15. FACILITY 858, PORTION OF NORTHEAST SIDE (APRON AVENUE SIDE), SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACILITY 858, PORTION OF NORTHEAST SIDE (APRON AVENUE SIDE), SHOWING CHEVRON DESIGN OVER FORMER PASSAGEWAY, OBLIQUE VIEW FACING WEST. - Schofield Barracks Military Reservation, Quadrangle K Barracks Type, Between Wilson Street & Capron Avenue near Williston Avenue, Wahiawa, Honolulu County, HI

  16. Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  17. PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE AVENUE IN CENTER, AND FORD PIQIETTE PLANT ON THE OTHER SIDE. (Duplicate color view of HAER MI-349-1) - 411 Piquette Avenue (Industrial), Detroit, MI

  18. View of Mueller property along East Avenue, looking northeast. Mueller ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Mueller property along East Avenue, looking northeast. Mueller house in the foreground and row of magnolia trees along East Avenue. - Ernst Mueller House, 6563 East Avenue, Rancho Cucamonga, San Bernardino County, CA

  19. 1. LOOKING EAST FROM 127125 JACKSON AVENUE (INDUSTRIAL COLLOIDS AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. LOOKING EAST FROM 127-125 JACKSON AVENUE (INDUSTRIAL COLLOIDS AND CHEMICALS, INC.) TO SULLIVAN'S SALOON (in background, with domed roof) - Jackson Avenue Warehouse District, 101-131 & 120-122 Jackson Avenue, Knoxville, Knox County, TN

  20. Contextual view of building 47 looking across Walnut Avenue, with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 47 looking across Walnut Avenue, with building 521 in foreground; camera facing northeast. - Mare Island Naval Shipyard, Old Administrative Offices, Eighth Street, north side between Railroad Avenue & Walnut Avenue, Vallejo, Solano County, CA

  1. Contextual view of building 47 looking across Walnut Avenue, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 47 looking across Walnut Avenue, showing south elevation; camera facing northwest. - Mare Island Naval Shipyard, Old Administrative Offices, Eighth Street, north side between Railroad Avenue & Walnut Avenue, Vallejo, Solano County, CA

  2. View southwest toward Eldred Avenue from within Friend's Burial Ground, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View southwest toward Eldred Avenue from within Friend's Burial Ground, Benjamin Carr Farm in distance through the trees - Friends' Burial Ground, Eldred & Beacon Avenues, Jamestown, Newport County, RI

  3. Microscopy Opening Up New Cancer Discovery Avenues

    Cancer.gov

    Today’s high-powered microscopes are allowing researchers to study the fine details of individual cells and to peer into cells, opening up new avenues of discovery about the inner workings of cells, including the events that can cause healthy cells to tra

  4. An Early Cretaceous garnet pressure-temperature path recording synconvergent burial and exhumation from the hinterland of the Sevier orogenic belt, Albion Mountains, Idaho

    NASA Astrophysics Data System (ADS)

    Kelly, Eric D.; Hoisch, Thomas D.; Wells, Michael L.; Vervoort, Jeffrey D.; Beyene, Mengesha A.

    2015-08-01

    Rocks may undergo complex pressure-temperature ( P- T) histories during orogenesis in response to alternating episodes of synconvergent burial and exhumation. In this study, chemical zoning in garnets combined with textural and chemical evidence from the schist of Willow Creek in the Albion Mountains of south-central Idaho (USA), reveals a complex P- T path during the early stages of Sevier orogenesis. The distribution of quartz inclusions combined with internal resorption features establishes a hiatus in garnet growth. Chemical zoning was simulated using a G-minimization approach to yield a P- T path consisting of three distinct pressure changes during increasing temperature, defining an "N" shape. Lu-Hf isochron ages from multiple garnet fractions and whole-rock analyses in two samples are 132.1 ± 2.4 and 138.7 ± 3.5 Ma. The samples were collected from the hanging wall of the Basin-Elba thrust fault and yielded results similar to those previously obtained from the footwall. This leads to several conclusions: (1) Both the hanging wall and footwall experienced the same metamorphic event, (2) the paths document a previously unrecognized crustal thickening and synorogenic extension cycle that fills an important time gap in the shortening history of the Sevier retroarc, suggesting progressive eastward growth of the orogen rather than a two-stage history, and (3) episodes of extensional exhumation during protracted convergent orogenesis are increasingly well recognized and highlight the dynamic behavior of orogenic belts.

  5. Shallow ground-water quality adjacent to burley tobacco fields in northeastern Tennessee and southwestern Virginia, spring 1997

    USGS Publications Warehouse

    Johnson, G.C.; Connell, J.F.

    2001-01-01

    In 1994, the U.S. Geological Survey began an assessment of the upper Tennessee River Basin as part of the National Water-Quality Assessment (NAWQA) Program. A ground-water land-use study conducted in 1996 focused on areas with burley tobacco production in northeastern Tennessee and southwestern Virginia. Land-use studies are designed to focus on specific land uses and to examine natural and human factors that affect the quality of shallow ground water underlying specific types of land use. Thirty wells were drilled in shallow regolith adjacent to and downgradient of tobacco fields in the Valley and Ridge Physiographic Province of the upper Tennessee River Basin. Ground-water samples were collected between June 4 and July 9, 1997, to coincide with the application of the majority of pesticides and fertilizers used in tobacco production. Ground-water samples were analyzed for nutrients, major ions, 79 pesticides, 7 pesticide degradation products, 86 volatile organic compounds, and dissolved organic carbon. Nutrient concentrations were lower than the levels found in similar NAWQA studies across the United States during 1993-95. Five of 30 upper Tennessee River Basin wells (16.7 percent) had nitrate levels exceeding 10 mg/L while 19 percent of agricultural land-use wells nationally and 7.9 percent in the Southeast had nitrate concentrations exceeding 10 mg/L. Median nutrient concentrations were equal to or less than national median concentrations. All pesticide concentrations in the basin were less than established drinking water standards, and pesticides were detected less frequently than average for other NAWQA study units. Atrazine was detected at 8 of 30 (27 percent) of the wells, and deethylatrazine (an atrazine degradation product) was found in 9 (30 percent) of the wells. Metalaxyl was found in 17 percent of the wells, and prometon, flumetralin, dimethomorph, 2,4,5-T, 2,4-D, dichlorprop, and silvex were detected once each (3 percent). Volatile organic compounds

  6. The timing of tertiary metamorphism and deformation in the Albion-Raft River-Grouse Creek metamorphic core complex, Utah and Idaho

    USGS Publications Warehouse

    Strickland, A.; Miller, E.L.; Wooden, J.L.

    2011-01-01

    The Albion-Raft River-Grouse Creek metamorphic core complex of southern Idaho and northern Utah exposes 2.56-Ga orthogneisses and Neoproterozoic metasedimentary rocks that were intruded by 32-25-Ma granitic plutons. Pluton emplacement was contemporaneous with peak metamorphism, ductile thinning of the country rocks, and top-to-thewest, normal-sense shear along the Middle Mountain shear zone. Monazite and zircon from an attenuated stratigraphic section in the Middle Mountain were dated with U-Pb, using a SHRIMP-RG (reverse geometry) ion microprobe. Zircons from the deformed Archean gneiss preserve a crystallization age of 2532 ?? 33 Ma, while monazites range from 32.6 ?? 0.6 to 27.1 ?? 0.6 Ma. In the schist of the Upper Narrows, detrital zircons lack metamorphic overgrowths, and monazites produced discordant U-Pb ages that range from 52.8 ?? 0.6 to 37.5 ?? 0.3 Ma. From the structurally and stratigraphically highest unit sampled, the schist of Stevens Spring, narrow metamorphic rims on detrital zircons yield ages from 140-110 Ma, and monazite grains contained cores that yield an age of 141 ??2 Ma, whereas rims and some whole grains ranged from 35.5 ?? 0.5 to 30.0 ?? 0.4 Ma. A boudinaged pegmatite exposed in Basin Creek is deformed by the Middle Mountains shear zone and yields a monazite age of 27.6 ?? 0.2 Ma. We interpret these data to indicate two periods of monazite and metamorphic zircon growth: a poorly preserved Early Cretaceous period (???140 Ma) that is strongly overprinted by Oligocene metamorphism (???32-27 Ma) related to regional plutonism and extension. ?? 2011 by The University of Chicago.

  7. Synextensional magmatism leading to crustal flow in the Albion-Raft River-Grouse Creek metamorphic core complex, northeastern Basin and Range

    NASA Astrophysics Data System (ADS)

    Konstantinou, Alexandros; Strickland, Ariel; Miller, Elizabeth; Vervoort, Jeffrey; Fisher, Christopher M.; Wooden, Joseph; Valley, John

    2013-09-01

    study addresses the origin of granitic magmas in the Albion-Raft River-Grouse Creek (ARG) metamorphic core complex and environs and how these inform us about the deep crustal processes leading to crustal flow and the formation of the ARG. SHRIMP-RG U-Pb zircon ages, whole-rock geochemical data (major and trace element data, as well as Sr and Nd isotopes), and zircon geochemistry (in situ O-isotope, Hf-isotope, and trace element compositions) from Eocene to Oligocene magmas now exposed at three structural levels of the ARG show that the 41-32 Ma Emigrant Pass and the 32-25 Ma Cassia plutonic complexes have a common origin, sharing a deep crustal "hot zone" that remained above solidus temperatures for at least 16 Myr. This magmatism is part of the protracted magmatism that swept southward across the western U.S. between ˜42 and 21 Ma, inferred to be the result of foundering of the shallow Farallon slab. Isotopic modeling of geochemical data from these magmas suggests that between 41 and 32 Ma, the influx of mantle-derived basalt into the lower crust triggered large-scale hybrid magmatism generating calc-alkaline magmas that erupted and intruded the upper crust and significantly weakened the lower and middle crust. Between 32 and 25 Ma, this "hot zone" incorporated large amounts of continental crustal melts, resulting in greater mobility of the lower and middle crust, driving middle crustal flow and the formation of granitic plutons that rose to shallower levels of the crust forming the granite-cored gneiss domes of the ARG.

  8. Cedar Creek at Cedartown, Georgia, floodflow characteristics from West Girard Avenue to the Georgia Avenue Relocation

    USGS Publications Warehouse

    Price, McGlone

    1981-01-01

    In cooperation with the Highway Division, Georgia Department of Transportation, the U.S. Geological Survey determined the backwater effects of existing bridges and dikes on Cedar Creek at Cedartown, Georgia, for the reach from West Girard Avenue to the Georgia Avenue relocation. The maximum backwater effect for the bridges was 1.7 feet in the upstream approach at the Seaboard Coastline Railroad bridge as a combined result of the Georgia Highway 278 bridge and the Seaboard Coastline Railroad bridge. The maximum effect from the existing dikes was 0.7 foot at the approach section of Georgia Highway 278.

  9. 1. View along centerline of Palm Avenue showing setting; 208 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View along centerline of Palm Avenue showing setting; 208 Palm at extreme left; note commercial intrusion at right; view to southwest. - T.J. Young Cottage, 208 Palm Avenue, Santa Barbara, Santa Barbara County, CA

  10. 1. View southeast from Eldred Avenue toward stone wall at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View southeast from Eldred Avenue toward stone wall at corner of Benjamin Carr Farm. Wall moved to current location in 1941-1942. - Benjamin Carr Farm, Route 138 (Eldred Avenue) & Helm Street, Jamestown, Newport County, RI

  11. 1. AERIAL VIEW, LOOKING WEST ALONG NORTH AVENUE. BRIDGE No. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. AERIAL VIEW, LOOKING WEST ALONG NORTH AVENUE. BRIDGE No. Z-2 AT CENTER LEFT OF FRAME. - Chicago, Milwaukee & St. Paul Railway, Bridge No. Z-2, Spanning North Branch Canal at North Cherry Avenue, Chicago, Cook County, IL

  12. 88. 451 MADISON AVENUE, LIBRARY, SOUTH WALL, WEST CENTRAL SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    88. 451 MADISON AVENUE, LIBRARY, SOUTH WALL, WEST CENTRAL SECTION SHOWING WINDOW AND RADIATOR (Pair with NY-5635-89) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  13. 6. IRON FENCE SEPARATING GRAY'S FERRY AVENUE AND NAVAL GROUNDS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. IRON FENCE SEPARATING GRAY'S FERRY AVENUE AND NAVAL GROUNDS. FENCE IS ORIGINAL--NOTE GREEK ACROTERIANS. - U. S. Naval Asylum, Biddle Hall, Gray's Ferry Avenue, Philadelphia, Philadelphia County, PA

  14. EXTERIOR VIEW, POWELL AVENUE (SOUTH) ELEVATION, PEDESTRIAN PASSAGEWAY AT LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR VIEW, POWELL AVENUE (SOUTH) ELEVATION, PEDESTRIAN PASSAGEWAY AT LEFT SIDE OF UNDERPASS - Twentieth Street Underpass, At Railroad Reservation, Twentieth Street at the Tracks between Morris & Powell Avenues, Birmingham, Jefferson County, AL

  15. 72. 451 MADISON AVENUE, GRAND STAIR, ZODIAC CLOCK WITH DECORATIVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. 451 MADISON AVENUE, GRAND STAIR, ZODIAC CLOCK WITH DECORATIVE CARVING BY STANFORD WHITE AND AUGUSTUS SAINT-GAUDENS - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  16. NORTH PORTAL OF VIADUCT WHERE IT MERGES WITH AURORA AVENUE; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH PORTAL OF VIADUCT WHERE IT MERGES WITH AURORA AVENUE; DENNY PARK AT TOP MIDDLE OF PICTURE. TOP OF PORTAL INTERSECTS WITH SEVENTH AVENUE ON THE DIAGONAL. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

  17. 8. 451 MADISON AVENUE, MAIN HALL, SOUTH WALL, MOSAIC TYMPANUM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. 451 MADISON AVENUE, MAIN HALL, SOUTH WALL, MOSAIC TYMPANUM OF THREE FIGURES IN BOLD RELIEF ABOVE FIREPLACE - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  18. FACING NORTH ALONG TERRACE AVENUE OF MAINTENANCE SHED AND LANDSCAPING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACING NORTH ALONG TERRACE AVENUE OF MAINTENANCE SHED AND LANDSCAPING IN NORTHEASTERN CORNER OF PARK - Candler Park Historic District, Roughly bounded by Moreland, Dekalb, McLendon & Harold Avenues, Matthews Street & Clifton Terrace, Atlanta, Fulton County, GA

  19. 2. VIEW OF SITE A FROM THORNE AVENUE, FACING NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF SITE A FROM THORNE AVENUE, FACING NORTHWEST. (BUILDINGS 120, 117, 121, 122, AND 129 ARE VISIBLE.) - Fort McPherson, World War II Station Hospital, Structures, Bordered by Hardee & Thorne Avenues & Howe Street, Atlanta, Fulton County, GA

  20. Perspective view looking along the Constitution Avenue facade, showing the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view looking along the Constitution Avenue facade, showing the twenty-seven bays and the three central arches that mark the entrance to the building - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

  1. 46. Exterior view at the corner of Seventh Avenue and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Exterior view at the corner of Seventh Avenue and Olive Way, looking NE. Opening night film, 'The Broadway Melody,' displayed on the canopy marquee. - Fox Theater, Seventh Avenue & Olive Way, Seattle, King County, WA

  2. 13. Tenth Avenue grade separation: south side with elevator no. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Tenth Avenue grade separation: south side with elevator no. 2 and track shed to left, facing north-northwest - Washburn Crosby Company Elevators No. 2 & 3, 900 & 1000 Second Avenue, South, Minneapolis, Hennepin County, MN

  3. Original blackandwhite print, VIEW OF UNFINISHED FACADE AT PENNSYLVANIA AVENUE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Original black-and-white print, VIEW OF UNFINISHED FACADE AT PENNSYLVANIA AVENUE AND ELEVENTH STREET - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

  4. 2. VIEW SHOWING WEST ELEVATION, EAST SIDE OF MEYER AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW SHOWING WEST ELEVATION, EAST SIDE OF MEYER AVENUE. Shows 499-501, Munoz House (AZ-73-37) on far right. - Antonio Bustamente House, 485-489 South Meyer Avenue & 186 West Kennedy Street, Tucson, Pima County, AZ

  5. VIEW SHOWING WEST ELEVATION, EAST SIDE OF MEYER AVENUE. SHOWS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SHOWING WEST ELEVATION, EAST SIDE OF MEYER AVENUE. SHOWS 499-501, MUNOZ HOUSE (AZ-73-37) ON FAR RIGHT - Antonio Bustamente House, 485-489 South Meyer Avenue & 186 West Kennedy Street, Tucson, Pima County, AZ

  6. Contextual view of building 505 Cedar avenue, showing south and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 505 Cedar avenue, showing south and east elevations; camera facing northwest. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  7. CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE; CAMERA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE; CAMERA FACING SOUTH - Mare Island Naval Shipyard, Bachelor Enlisted Quarters & Offices, Walnut Avenue, east side between D Street & C Street, Vallejo, Solano County, CA

  8. CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE, SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE, SHOWING WEST ELEVATION. CAMERA FACING SOUTH - Mare Island Naval Shipyard, Bachelor Enlisted Quarters & Offices, Walnut Avenue, east side between D Street & C Street, Vallejo, Solano County, CA

  9. Close view of the Constitution Avenue elevation to show arched ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close view of the Constitution Avenue elevation to show arched gateways and pedimented pavilion ("Commerce and Communication" sculpted pediment) - Interstate Commerce Commission, Constitution Avenue between Twelfth and Fourteenth streets, Washington, District of Columbia, DC

  10. Close view of the south facade on Constitution Avenue to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close view of the south facade on Constitution Avenue to show main entrance - United States Department of Justice, Constitution Avenue between Ninth & Tenth Streets, Northwest, Washington, District of Columbia, DC

  11. View of east elevation along California Avenue; camera facing west. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of east elevation along California Avenue; camera facing west. - Mare Island Naval Shipyard, Rubber Shop, California Avenue, west side across from Dry Dock 1 near Ninth Street, Vallejo, Solano County, CA

  12. 41. 451 MADISON AVENUE, DINING ROOM, NORTH WALL, DETAIL OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. 451 MADISON AVENUE, DINING ROOM, NORTH WALL, DETAIL OF LEATHER DOOR PANEL WITH DECORATIVE NAILHEAD PATTERN - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  13. 4. AERIAL VIEW OF SEGMENT OF VIRGINIA AVENUE BETWEEN SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. AERIAL VIEW OF SEGMENT OF VIRGINIA AVENUE BETWEEN SOUTH CAPITOL AND FOURTH STREET, SE, LOOKING EAST. VIEW INCLUDES GARFIELD PARK, RESERVATION NO. 17. - Virginia Avenue, Washington, District of Columbia, DC

  14. Contextual view along Blake Avenue showing north and west elevations; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view along Blake Avenue showing north and west elevations; camera facing southeast. - Mare Island Naval Shipyard, Magazine No. 2, Railroad Avenue, west side near intersection with Imhoff Road, Vallejo, Solano County, CA

  15. Overview looking parallel to Avenue E down the south side ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Overview looking parallel to Avenue E down the south side of Facility 1C. Avenue E (Russell Avenue) to the left hand side of the shot. Parallel parking area in front of Facility 1C. Taken from Facility 207. View facing northwest. - U.S. Naval Base, Pearl Harbor, Administration Office Annex--Southeast Extension, Avenue E between Seventh & Eighth Streets, Pearl City, Honolulu County, HI

  16. 2. AERIAL VIEW, LOOKING WEST, ALONG FIRST AVENUE NORTH, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. AERIAL VIEW, LOOKING WEST, ALONG FIRST AVENUE NORTH, WITH BROWN MARX BUILDING (BOTTOM CENTER TO RIGHT), EMPIRE BUILDING (CENTER TOP) WITH ITS TERRACOTTA-CLAD 20TH STREET AND FIRST AVENUE FACADES, AND JOHN HAND BUILDING - Heaviest Corner on Earth (Commercial), First Avenue, North & Twentieth (20th) Street, North, Birmingham, Jefferson County, AL

  17. LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 AND 1041 (QUARTERS 1 AND J) AT LEFT. VIEW FACING SOUTHWEST. - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Hale Alii Avenue, Eighth Street, & Avenue D, Pearl City, Honolulu County, HI

  18. 1. AERIAL VIEW FROM THE SW OF NORTH AVENUE BRIDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. AERIAL VIEW FROM THE SW OF NORTH AVENUE BRIDGE TO THE RIGHT. CHICAGO, MILWAUKEE AND ST PAUL 'Z-2' RAILROAD BRIDGE ON RIGHT. - North Avenue Bridge, Spanning North Branch of Chicago River at West North Avenue, Chicago, Cook County, IL

  19. View of Foothill Avenue. Buildings No. 40, 42, 44, 45, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Foothill Avenue. Buildings No. 40, 42, 44, 45, 41, and 39 seen from left to right. Note rolled curbing. Looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  20. View of Hinkley Avenue looking towards former intersection with Hoffman ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue looking towards former intersection with Hoffman Boulevard. Note former building site of Building No. 1 at right rear. Looking southwest - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  1. View of Parking Area No. 11 on Hinkley Avenue. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Parking Area No. 11 on Hinkley Avenue. Building No. 14 at left. Looking southeast - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  2. View of Parking Area No. 32 from Foothill Avenue. Buildings ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Parking Area No. 32 from Foothill Avenue. Buildings No. 23, 24, 34, 25, and 35, from left to right. Looking south - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  3. View of Hinkley Avenue from former intersection with Hoffman Boulevard. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue from former intersection with Hoffman Boulevard. Note reconstructed Easter Hill Buildings No. 2, 3, and 4 from left to right at rear. Looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  4. View of Hinkley Avenue at Hinkley Square intersection. Note reconstructed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue at Hinkley Square intersection. Note reconstructed Easter Hill Building No. 4 on left and Building No. 6 on right. Looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  5. View of Foothill Avenue seen from Building No. 41. Buildings ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Foothill Avenue seen from Building No. 41. Buildings No. 41, 39, 37, 38, and 40 from left to right - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  6. View of Hinkley Avenue. Parking Area No. 7 on right, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue. Parking Area No. 7 on right, Building No. 8 on right and Building No. 9 on left. Looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  7. VIEW OF 2328 PIEDMONT AVENUE, CHARLES MILLS GAYLEY HOUSE DESIGNED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF 2328 PIEDMONT AVENUE, CHARLES MILLS GAYLEY HOUSE DESIGNED BY JULIA MORGAN, 1905. SEEN FROM SIDEWALK LOOKING NW TOWARDS DURANT AVENUE. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  8. 24. View of west side of South Coweta Avenue south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. View of west side of South Coweta Avenue south of East Ward Street, facing northwest. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  9. 22. View of east side of South Gaskin Avenue at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. View of east side of South Gaskin Avenue at the intersection with East Ashley Street, facing east. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  10. 23. View of west side of South Coweta Avenue south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. View of west side of South Coweta Avenue south of East Ward Street, facing west. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  11. Avenues for crowd science in Hydrology.

    NASA Astrophysics Data System (ADS)

    Koch, Julian; Stisen, Simon

    2016-04-01

    Crowd science describes research that is conducted with the participation of the general public (the crowd) and gives the opportunity to involve the crowd in research design, data collection and analysis. In various fields, scientists have already drawn on underused human resources to advance research at low cost, with high transparency and large acceptance of the public due to the bottom up structure and the participatory process. Within the hydrological sciences, crowd research has quite recently become more established in the form of crowd observatories to generate hydrological data on water quality, precipitation or river flow. These innovative observatories complement more traditional ways of monitoring hydrological data and strengthen a community-based environmental decision making. However, the full potential of crowd science lies in internet based participation of the crowd and it is not yet fully exploited in the field of Hydrology. New avenues that are not primarily based on the outsourcing of labor, but instead capitalize the full potential of human capabilities have to emerge. In multiple realms of solving complex problems, like image detection, optimization tasks, narrowing of possible solutions, humans still remain more effective than computer algorithms. The most successful online crowd science projects Foldit and Galaxy Zoo have proven that the collective of tens of thousands users could clearly outperform traditional computer based science approaches. Our study takes advantage of the well trained human perception to conduct a spatial sensitivity analysis of land-surface variables of a distributed hydrological model to identify the most sensitive spatial inputs. True spatial performance metrics, that quantitatively compare patterns, are not trivial to choose and their applicability is often not universal. On the other hand humans can quickly integrate spatial information at various scales and are therefore a trusted competence. We selected

  12. 12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING DEVELOPMENT. 'BURBANK FARM' ON RIGHT. TALL TREE TO RIGHT OF STREET LIGHT IS EUCALYPTUS ON WEST OF COTTAGE WHICH IS PLANNED FOR REMOVAL. 13. 'BURBANK FARM' SHOWING BANK CUT CREATED WHEN BODEGA AVENUE ROADBED WAS LOWERED. WPA STONE RETAINING WALL AT BASE OF CUT. LOOKING SOUTHWEST. - Gold Ridge Farm, 7777 Bodega Avenue, Sebastopol, Sonoma County, CA

  13. Management engineering (building no. 4), looking west along Porter Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Management engineering (building no. 4), looking west along Porter Avenue. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  14. ENTRANCE GATE AND MEMORIAL AVENUE APPROACH, LOOKING INTO CEMETERY WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ENTRANCE GATE AND MEMORIAL AVENUE APPROACH, LOOKING INTO CEMETERY WITH ADMINISTRATION BUILDING IN BACKGROUND. VIEW TO NORTHWEST. - Mountain Home National Cemetery, Mountain Home, Washington County, TN

  15. View of southwest elevation of Building No. 42. Foothill Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of southwest elevation of Building No. 42. Foothill Avenue in foreground, seen from yard of Building No. 41, Building No. 44 at rear. Looking northeast - Easter Hill Village, Building No. 42, Northwest corner of Foothill Avenue & South Twenty-eighth Street, Richmond, Contra Costa County, CA

  16. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY VIEW OF 2401 PIEDMONT, ALPHA EPSILON PHI HOUSE BY RATCLIFF & RATCLIFF, 1958. SEEN FROM NW CORNER LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  17. 61. PHOTOCOPY OF MAP OF EXISTING CONDITIONS BETWEEN MASSACHUSETTS AVENUE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. PHOTOCOPY OF MAP OF EXISTING CONDITIONS BETWEEN MASSACHUSETTS AVENUE AND POTOMAC RIVER, FROM REPORT ON THE IMPROVEMENT OF VALLEY OF ROCK CREEK, FROM MASSACHUSETTS AVENUE TO THE MOUTH OF THE CREEK, SENATE DOC. No. 458, 60th CONG., 1st SESS., 1908 - Rock Creek & Potomac Parkway, Washington, District of Columbia, DC

  18. Looking west along Railroad Avenue toward the Fire House, visible ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking west along Railroad Avenue toward the Fire House, visible in the center distance, behind the left Sentry House. The historic Marine Barracks (Building 930) is also visible at the far left, and Building 1296 in the right distance - Mare Island Naval Shipyard, South Fire Station, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

  19. 1. 319 EAST COMMERCIAL AVENUE IS THE SINGLE STORY BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 319 EAST COMMERCIAL AVENUE IS THE SINGLE STORY BUILDING IN THE CENTER OF THE PHOTOGRAPH. IT IS DISTINGUISHED BY ITS CAST METAL FACADE WITH WOODEN INLAY, AND THE PRESSED METAL CORNICE AT THE PARAPET WALL - Anaconda Historic District, 319 East Commercial Avenue, Anaconda, Deer Lodge County, MT

  20. LOOKING WNW, CHEVROLET AVENUE BRIDGE CROSSING FLINT RIVER. BRIDGE CONNECTED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING WNW, CHEVROLET AVENUE BRIDGE CROSSING FLINT RIVER. BRIDGE CONNECTED NORTH AND SOUTH PORTIONS OF FACTORY COMPLEX. DANIEL LUTEN DESIGNED THE BRIDGE, AND ILLINOIS BRIDGE COMPANY BUILT IT IN 1918. THE BRIDGE WAS THE SITE OF THE BATTLE OF RUNNING BULLS IN THE 1936-1937 GM SIT DOWN STRIKE. - Delphi Flint West, 300 Chevrolet Avenue, Flint, Genesee County, MI

  1. VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. SEEN FROM WEST SIDE OF PIEDMONT AVE. LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 8, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  2. VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. INTERSECTION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF DWIGHT WAY. INTERSECTION OF HASTE STREET SEEN AT CENTER DISTANCE. SEEN FROM WEST SIDE OF PIEDMONT AVE. LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 8, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  3. 9. 451 MADISON AVENUE, MAIN HALL, SOUTH WALL, MOSAIC TYMPANUM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. 451 MADISON AVENUE, MAIN HALL, SOUTH WALL, MOSAIC TYMPANUM WITH SHELL AND URN MOTIF ENTITLED 'PAX' BY AUGUSTUS SAINT-GAUDENS TO WEST OF FIREPLACE - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  4. Context view from intersection of Assiniboine Avenue and H Street ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context view from intersection of Assiniboine Avenue and H Street showing building No. 61 in alignment of government houses, view to north - Fort Peck Indian Boarding School, Employee's Quarters, Northwest corner of Assiniboine Avenue and H Street, Poplar, Roosevelt County, MT

  5. 3. VIEW OF CENTRAL AVENUE LOOKING WEST FROM JUST EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF CENTRAL AVENUE LOOKING WEST FROM JUST EAST OF THE INTERSECTION OF CENTRAL AVENUE AND THE EAST PERIMETER ROAD. THE ROCKY FLATS PLANT IS ABOUT 16 MILES NORTHWEST OF DENVER ON A PLATEAU AT THE EASTERN EDGE OF THE FRONT RANGE OF THE ROCKY MOUNTAINS. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  6. VIEW FROM CENTER OF ELM AVENUE, LOOKING WEST INTO SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FROM CENTER OF ELM AVENUE, LOOKING WEST INTO SECTION L. AT LEFT STANDS THE PONDEROUS MCDANIEL MAUSOLEUM, WHICH SHOWS THE INFLUENCE OF FRANK FURNESS ON H. Q. FRENCH’S 1887 DESIGN - Woodlands Cemetery, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

  7. 39. Drawing entitled 5000 Wissahickon Avenue, North and East Elevations. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. Drawing entitled 5000 Wissahickon Avenue, North and East Elevations. Leon Clemmer A.I.A. & Associates, Wyncote, Pennsylvania, for the General Services Administration, Public Buildings Service, Washington, D.C. (undated) - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

  8. VIEW OF PIEDMONT AVENUE AT INTERSECTION OF DURANT STREET. SEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT INTERSECTION OF DURANT STREET. SEEN FROM NW CORNER LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  9. VIEW OF PIEDMONT AVENUE AT BANCROFT WAY. SEEN FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT BANCROFT WAY. SEEN FROM WEST SIDE OF PIEDMONT LOOKING SE. INTERNATIONAL HOUSE ON THE NORTHEAST SIDE AT 2299 PIEDMONT BY GEORGE W. KELHAM, 1929. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  10. VIEW OF PIEDMONT AVENUE AND MEDIAN. REPLICATING WERNER HEGEMANN PHOTO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AND MEDIAN. REPLICATING WERNER HEGEMANN PHOTO TAKEN CIRCA 1909 SEEN FROM TRAFFIC CIRCLE AT CHANNING WAY LOOKING NW. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  11. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM SW CORNER TOWARDS 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. LOOKING NORTH. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  12. VIEW OF PIEDMONT AVENUE NEAR NORTH END OF STADIUM. SEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NEAR NORTH END OF STADIUM. SEEN FROM EAST SIDE OF PIEDMONT LOOKING SOUTH. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  13. VIEW OF PIEDMONT AVENUE AT INTERSECTION OF HASTE STREET, CHATEAU ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT INTERSECTION OF HASTE STREET, CHATEAU APARTMENTS BY CLARENCE CASEBOLT DAKIN, 1929 AT 2747 HASTE ON WEST SIDE OF PIEDMONT. LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 8, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  14. VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY LOOKING SOUTHWEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY LOOKING SOUTHWEST ACROSS MEDIAN FROM MEMORIAL STADIUM. Photograph by Fredrica Drotos and Michael Kelly, July 16, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  15. VIEW OF PIEDMONT AVENUE AT INTERSECTION OF HASTE STREET, NOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT INTERSECTION OF HASTE STREET, NOTE RECONSTRUCTION OF MEDIAN FROM PREVIOUS VIEW IN PHOTOGRAPH CA-2-5. LOOKING NW. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  16. VIEW OF PIEDMONT AVENUE AT BANCROFT WAY, REPLICATING WERNER HEGEMANN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT BANCROFT WAY, REPLICATING WERNER HEGEMANN PHOTO CIRCA 1909, SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  17. VIEW OF WEST SIDE OF PIEDMONT AVENUE NEAR INTERSECTION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF WEST SIDE OF PIEDMONT AVENUE NEAR INTERSECTION OF CHANNING WAY. LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  18. VIEW OF PIEDMONT AVENUE AT INTERSECTION WITH DWIGHT WAY. SEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT INTERSECTION WITH DWIGHT WAY. SEEN FROM SW CORNER LOOKING NW. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  19. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM NE CORNER LOOKING SW. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  20. VIEW OF PIEDMONT AVENUE AT CHANNING WAY. NOTE LANDSCAPE FEATURES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT CHANNING WAY. NOTE LANDSCAPE FEATURES PRIOR TO RECONSTRUCTION AND NEW CURBING AS SEEN IN PHOTOGRAPH NO. CA-2-8. LOOKING NE. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  1. DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM EAST SIDE OF CIRCLE LOOKING NORTH AT 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  2. NORTH END OF PIEDMONT AVENUE. STADIUM AT LEFT REAR. SEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH END OF PIEDMONT AVENUE. STADIUM AT LEFT REAR. SEEN FROM WEST SIDE OF PIEDMONT LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  3. ALTERNATE VIEW OF PIEDMONT AVENUE AT BANCROFT WAY. SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ALTERNATE VIEW OF PIEDMONT AVENUE AT BANCROFT WAY. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  4. 6. VIEW FROM AVENUE 26 BRIDGE OF ARROYO SECO PARKWAY. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW FROM AVENUE 26 BRIDGE OF ARROYO SECO PARKWAY. NOTE CHANGE IN ELEVATION OF SOUTHBOUND LANES TO MEET GRADE FOR ELYSIAN PARK ROAD CUT. INTERSTATE I-5 IN CENTER REAR. LOOKING 232°SW. - Arroyo Seco Parkway, Avenue 26 Bridge, Milepost 25.91, Los Angeles, Los Angeles County, CA

  5. VIEW OF PIEDMONT AVENUE AT ENTRANCE ROAD TO UNIVERSITY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT ENTRANCE ROAD TO UNIVERSITY OF CALIFORNIA FACULTY CLUB. NOTE CHANGE IN LEVELS OF NORTH AND SOUTH BOUND SIDES OF ROAD. LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  6. 1. VIEW SHOWING WEST ELEVATION ON SOUTH MEYER AVENUE & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW SHOWING WEST ELEVATION ON SOUTH MEYER AVENUE & 186 W. KENNEDY ST., NORTH SIDE OF BUILDING ON SOUTH SIDE OF WEST KENNEDY ST. - Antonio Bustamente House, 485-489 South Meyer Avenue & 186 West Kennedy Street, Tucson, Pima County, AZ

  7. 4. View west of Eldred Avenue towards the Jamestown Bridge, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. View west of Eldred Avenue towards the Jamestown Bridge, Benjamin Carr Farm to the south (left), Friends' Burial Ground to the north (right) in the background with stone wall and Cedar Hill Cemetery to the north (right) in the foreground with white picket fence. (See also HABS No. RI-398) - Benjamin Carr Farm, Route 138 (Eldred Avenue) & Helm Street, Jamestown, Newport County, RI

  8. 4. Passaic River looking northwest from Ackerman Avenue bridge; Dundee ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Passaic River looking northwest from Ackerman Avenue bridge; Dundee Textile Company Mill at left - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

  9. 16. Fifth Melan Bridge on tour route, Union Avenue near ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Fifth Melan Bridge on tour route, Union Avenue near Park Boundary, closer view of surface showing cracks, view to the south. - Vicksburg National Military Park Roads & Bridges, Melan Arch Bridges, Spanning various tributaries at Confederate Avenue, Vicksburg, Warren County, MS

  10. VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. NOTE OAK GROVE AND UNIVERSITY OF CALIFORNIA FOOTBALL STADIUM AT RIGHT REAR. NOTE STAIRCASE IN MEDIAN. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  11. Contextual view of building A266 along blake avenue, showing north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building A266 along blake avenue, showing north and west elevations, camera facing southeast. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  12. 5. HISTORIC VIEW LOOKING FROM PENNSYLVANIA AVENUE BRIDGE SOUTH TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. HISTORIC VIEW LOOKING FROM PENNSYLVANIA AVENUE BRIDGE SOUTH TO OLD (1907 STEEL-GIRDER) K STREET BRIDGE. MLK LIBRARY. - K Street Bridge, Spanning Rock Creek & Potomac Parkway, Washington, District of Columbia, DC

  13. 27. Yards north of Branch Avenue Bridge. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Yards north of Branch Avenue Bridge. Providence, Providence Co., RI. Sec. 4116, mp 186.25. - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  14. 28. Yards north of Branch Avenue Bridge. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Yards north of Branch Avenue Bridge. Providence, Providence Co., RI. Sec. 4116, mp 186.25. - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  15. VIEW SOUTHSOUTH CLINTON AVENUE BUILDING 35 CLINTON ST. WIRE MILL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTH-SOUTH CLINTON AVENUE BUILDING 35 CLINTON ST. WIRE MILL (1899) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  16. View of steel warehouses at Gilmore Avenue (building 710 second ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of steel warehouses at Gilmore Avenue (building 710 second in on left); camera facing east. - Naval Supply Annex Stockton, Steel Warehouse Type, Between James & Humphreys Drives south of Embarcadero, Stockton, San Joaquin County, CA

  17. 5. VIEW OF NORTH PARK AVENUE TRAILHEAD PARKING AREA FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW OF NORTH PARK AVENUE TRAILHEAD PARKING AREA FACING SOUTHEAST. - Arches National Park Main Entrance Road, Beginning at U.S. Highway 191, approximately 6 miles north of Moab, Moab, Grand County, UT

  18. Looking east along Porter Avenue, management engineering in foreground; supply ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking east along Porter Avenue, management engineering in foreground; supply department storehouse (building no. 5) (Haer no. PA-387-1) to left. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  19. NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), SALT LAKE CITY, UT. VIEW LOOKING SOUTH AT CEMETERY'S NORTH GATE (WPA PROJECT, 1938-1941). - Salt Lake City Cemetery, 200 N Street, Salt Lake City, Salt Lake County, UT

  20. 20. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, ARCH DETAIL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, ARCH DETAIL SHOWING BRICK ARCH FOR MAIN SPAN AND STONE VOUSSOIRS. VIEW W. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  1. 9. REYNOLDS AVENUE BRIDGE, ROAD VIEW. NOTE THE GRADE RISES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. REYNOLDS AVENUE BRIDGE, ROAD VIEW. NOTE THE GRADE RISES OVER TRACKS DUE TO INCREASED LOCOMOTIVE SIZES. SEVERAL MONUMENTS WERE MOVED TO FACILITATE THIS. VIEW NE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  2. 15. MEREDITH AVENUE, VIEW WITH LOG RAIL AND BARN. PERHAPS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. MEREDITH AVENUE, VIEW WITH LOG RAIL AND BARN. PERHAPS THE LAST REMAINING EXAMPLE OF CCC BUILT "RUSTIC STYLE" GUARD RAIL IN PARK. VIEW NE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  3. 24. WEST CONFEDERATE AVENUE, DOUBLE CULVERT APPEARS TO BE "BOX", ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. WEST CONFEDERATE AVENUE, DOUBLE CULVERT APPEARS TO BE "BOX", BUT IS PIPE WITH SQUARE HEAD WALL OPENING. NOTE ARCHED TOP STYLE USED BY CCC. VIEW SE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  4. VIEW ALONG OHIO AVENUE, LOOKING TOWARD 1905 BAND BARRACKS (BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW ALONG OHIO AVENUE, LOOKING TOWARD 1905 BAND BARRACKS (BUILDING 61 O)CENTER AND FORAGE HOUSE (BUILDING 476)LEFT. VIEW TO NORTHWEST - Plattsburgh Air Force Base, U.S. Route 9, Plattsburgh, Clinton County, NY

  5. 24. Looking E toward Boston harbor along NEC; Berkley Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Looking E toward Boston harbor along NEC; Berkley Avenue Bridge in foreground. Boston, Suffolk Co., MA. Sec. 4116, MP 227.99. - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  6. Contextual view of Fyffe Avenue. Police station (building no. 17) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue. Police station (building no. 17) is shown in foreground. Camera facing northwest. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  7. 4. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, SHOWING DETAIL OF TRACK WORK AND OVERHEAD WIRING - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  8. 9. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING SOUTHEAST FROM WAREHOUSE, SHOWING TRACK MATERIAL STORED IN YARD - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  9. 23. View of Jwing left, at Mercury Avenue, looking west ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. View of J-wing left, at Mercury Avenue, looking west - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  10. 17. View of Mercury Avenue from Apollo Drive, looking north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. View of Mercury Avenue from Apollo Drive, looking north at E-wing - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  11. 22. WEST CONFEDERATE AVENUE BRIDGE SPANNING SPANGLER'S RUN. NOTE MORE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. WEST CONFEDERATE AVENUE BRIDGE SPANNING SPANGLER'S RUN. NOTE MORE RANDOM ASHLAR COURSING AND ARCH TO PARAPET. BRIDGE WAS WIDENED BY NPS USING CCC LABOR. VIEW SSE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  12. 2. HISTORIC PHOTOGRAPH, VIEW ALONG NEW CANAAN AVENUE TO MERRITT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. HISTORIC PHOTOGRAPH, VIEW ALONG NEW CANAAN AVENUE TO MERRITT PARKWAY BRIDGE, CA. 1940. COLLECTION CONNECTICUT DEPARTMENT OF TRANSPORTATION. - Merritt Parkway, New Canaan Road/Route 123 Bridge, Spanning New Canaan Road/Route 123, Norwalk, Fairfield County, CT

  13. VIADUCT LOOKING SOUTHEAST WHERE IT CROSSES ELLIOTT AVENUE AT BOTTOM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIADUCT LOOKING SOUTHEAST WHERE IT CROSSES ELLIOTT AVENUE AT BOTTOM OF PICTURE AND PASSES ALONG WATERFRONT PARK AND PIKE PLACE. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

  14. 22. View looking north on Central Avenue from Washington Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. View looking north on Central Avenue from Washington Street. The Stroud Building (with awnings on the second story) is located on the east (right) side of the street near the center of the block. The original Adams Hotel is seen at the right rear of the photograph Circa 1901-1910. Credit ADLAPR. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

  15. GENERAL VIEW, MAIN ENTRANCE GATES, LOOKING SOUTH ACROSS WOODLANDS AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW, MAIN ENTRANCE GATES, LOOKING SOUTH ACROSS WOODLANDS AVENUE. IN 1933, A CITY OF PHILADELPHIA LAND CONDEMNATION REQUIRED THE DEMOLITION OF AN EXISTING GATEWAY COMPLETED IN 1857 ON PLANS BY JOHN MCARTHUR, JR. PAUL CRET DESIGNED THE NEW GATES IN 1936. THEY WERE COMPLETED THE FOLLOWING YEAR AND MOVED TO THEIR PRESENT LOCATION IN 1948 AFTER ANOTHER CITY LAND CONDEMNATION. - Woodlands Cemetery, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

  16. VIEW OF PIEDMONT AVENUE AT BANCROFT WAY SEEN FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT BANCROFT WAY SEEN FROM WEST SIDE OF PIEDMONT LOOKING SOUTH WITH BRICK WALL RUNNING NORTH TO SOUTH IN FRONT OF 2302 PIEDMONT (F. WOODWARD HOUSE BY EDWARD B. SEELY, 1909). Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  17. VIEW OF PIEDMONT AVENUE AT BANCROFT WAY. SEEN FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT BANCROFT WAY. SEEN FROM WEST SIDE OF PIEDMONT REPLICATING HISTORIC PHOTOGRAPH CIRCA 1912 TAKEN FROM NORTH SIDE OF BANCROFT WAY. NOTE INTERNATIONAL HOUSE AT 2299 PIEDMONT ON EAST SIDE OF MEDIAN. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  18. VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. NOTE STAIRCASE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. NOTE STAIRCASE IN MEDIAN IS SAME AS SEEN IN PHOTO NO. CA-2-30, NOTE DOME OF INTERNATIONAL HOUSE AT 2299 PIEDMONT SEEN ACROSS THE MEDIAN IN THE SOUTHEAST FROM WEST SIDE OF PIEDMONT LOOKING SSE. Photograph by Fredrica Drotos and Michael Kelly, July 16, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  19. DETAIL VIEW OF NORTH BOUND LANE OF PIEDMONT AVENUE BEFORE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF NORTH BOUND LANE OF PIEDMONT AVENUE BEFORE INTERSECTION OF DURANT STREET. NOTE RECONSTRUCTION OF MEDIAN CURBING FROM PHOTOGRAPH NO. CA-2-19. NOTE GREENE AND GREENE HOUSE (THORSEN HOUSE) AT RIGHT REAR. LOOKING NORTH. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  20. GENERAL VIEW, WEST SIDE OF UBER STREET FROM SUSQUEHANNA AVENUE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW, WEST SIDE OF UBER STREET FROM SUSQUEHANNA AVENUE, LOOKING SOUTHWEST. THE PHILADELPHIA REAL ESTATE RECORD AND BUILDERS’ GUIDE ANNOUNCED IN AUGUST 1886 THAT A “COL. FLOOD” HAD “JUST FINISHED” THIRTY-TWO NINE AND TEN-ROOM HOUSES ON UBER STREET, SIXTEEN ON EACH SIDE ARRANGED IN EIGHT PAIRS OF TWO. WILLIS G. HALE WAS THE ARCHITECT USED FOR THE PROJECT. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  1. 69. 129 HILLSIDE AVENUE, BRONX, SUBSTATION, D. C. SIDE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    69. 129 HILLSIDE AVENUE, BRONX, SUBSTATION, D. C. SIDE OF ROTARY VISIBLE-NOTE COPPER BRUSHES IN PLACE OF SLIP RINGS. THE THREE TRANSFORMER '5'S REDUCE VOLTAGE OF CURRENT PASSING TO ROTARY '5'. NOTE ROTARY CONVERTER MOUNTED IN HARDWOOD BASE INDEPENDENT OF SUBSTATION FLOOR. - Interborough Rapid Transit Subway (Original Line), New York County, NY

  2. 5. HANCOCK AVENUE NEAR HIGH WATER MARK LOOKING SOUTH TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. HANCOCK AVENUE NEAR HIGH WATER MARK LOOKING SOUTH TO PENNSYLVANIA MONUMENT. NOTE LINE OF MONUMENTS AND CONTEMPORARY ADAPTATION OF GUTTER, (PAVED WITH YELLOW CAUTION MARKINGS) NOT STONE LINED. VIEW S. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  3. 12. DOUBLEDAY AVENUE NEAR MUMMASBURG ROAD. NOTE TRUNCATED OBSERVATION TOWER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. DOUBLEDAY AVENUE NEAR MUMMASBURG ROAD. NOTE TRUNCATED OBSERVATION TOWER AND ROAD SIGN VARIATIONS (CAST IRON PLACE NAME AT LEFT / AUTO TOUR SIGN AT RIGHT). ALSO NOTE CONCRETE BOLLARDS TO CONTROL PARKING. VIEW S. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  4. 17. VIEW OF RCA COMMUNICATIONS RECEIVING STATION DOWN AVENUE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. VIEW OF RCA COMMUNICATIONS RECEIVING STATION DOWN AVENUE OF MONTEREY CYPRESS. THE TREES WERE CAREFULLY CULTIVATED TO FORM A LANDSCAPED APPROACH TO THE STATION. NOTE ANTENNA FIELD AT LEFT VIEW 312 DEGREES NORTHWEST. - Marconi Radio Sites, Receiving, Point Reyes Station, Marin County, CA

  5. What Would Madison Avenue Do? Marketing to Teens

    ERIC Educational Resources Information Center

    Goodstein, Anastasia

    2008-01-01

    Whether one works for Nike or in a library, it is tough to attract an audience. That is where smart marketing can make all the difference. Even though libraries do not have millions of dollars to spend on slick Madison Avenue ad campaigns to entice today's teens, librarians do have access to the media that kids love, and that is a great place to…

  6. LAWRENCE AVENUE UNDERFLOW SEWER SYSTEM: MONITORING AND EVALUATION

    EPA Science Inventory

    A new and bold concept in design of urban drainage systems was developed as a step forward in the solution of combined sewer overflow problems. A deep tunnel in bed rock about 200 to 250 feet (61 to 76 m) below the surface was designed and constructed for the Lawrence Avenue drai...

  7. VIEW SOUTH FROM HAMILTON AVENUE BUILDING 25 LEFT; BUILDING 32 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTH FROM HAMILTON AVENUE BUILDING 25 LEFT; BUILDING 32 MACHINE SHOP (1890) LEFT CENTER BUILDING 31 RIGGER'S SHOP (1890) CENTER BUILDING 28 BLACKSMITH SHOP (1885) RIGHT CENTER; BUILDING 27 PATTERN SHOP (1853) RIGHT - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  8. 4. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION WITH SEVENTH STREET. THE PLANT HAS MOST OF THE AMENITIES OF A SMALL TOWN - WATER SUPPLY, WASTE WATER TREATMENT, POLICE FORCE, FIRE DEPARTMENT, FOOD SERVICES, HOSPITAL, COMMUNICATIONS NETWORK, STEAM GENERATION, VEHICLE MAINTENANCE, TRANSPORTATION, AND A GOVERNMENT. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  9. VIEW NORTH ON SOUTH CLINTON AVENUE LEFT CENTERBUILDING 7 MACHINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW NORTH ON SOUTH CLINTON AVENUE LEFT CENTER-BUILDING 7 MACHINE SHOP (1901 LEFT 1890 RIGHT) RIGHT-BUILDING 79 EMPLOYMENT OFFICE (1919) RIGHT CENTER-2 STORY-BUILDING 10 STORE HOUSE (1927) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  10. Contextual view of Fyffe Avenue between Jones and Boone Drives. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue between Jones and Boone Drives. ASA office (U.S. Border Control Environmental Office Building no. 317) is shown at center. Camera facing east. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  11. Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval Medical Center Oakland and Dental Clinic San Francisco Branch Clinics, Building no. 417) is shown at left. Camera facing northwest. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  12. Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue and Boone Drive. Dispensary (Naval Medical Center Oakland and Dental Clinic San Francisco Branch Clinics, building no. 417) is shown at the center. Camera facing northeast. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  13. View of intersection of Foothill Avenue and South TwentySixth Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of intersection of Foothill Avenue and South Twenty-Sixth Street. Note sports field at center rear. Seen from Foothill Avenue at Parking Area No. 34, looking southwest - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  14. 22. AERIAL VIEW LOOKING EAST DOWN CENTRAL AVENUE FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. AERIAL VIEW LOOKING EAST DOWN CENTRAL AVENUE FROM WEST OF THE ADMINISTRATIVE AND SUPPORT AREA OF THE PLANT. ON THE LEFT (NORTH) SIDE OF THE STREET IN THE FOREGROUND OF THE PHOTOGRAPH IS BUILDING 111, THE GENERAL ADMINISTRATION BUILDING. TO THE EAST OF BUILDING 111 IS BUILDING 112, THE CAFETERIA. FURTHER TO THE EAST IS BUILDING 331, THE VEHICLE MAINTENANCE GARAGE AND FIRE DEPARTMENT; BUILDING 333, THE PAINT SHOP; BUILDING 334, THE ELECTRICAL AND GENERAL MAINTENANCE SHOP; AND BUILDING 551, THE GENERAL WAREHOUSE. ON THE RIGHT (SOUTH) SIDE OF CENTRAL AVENUE, IN THE FOREGROUND IS BUILDING 121, FIREARMS REPAIR. BEHIND BUILDING 121 IS BUILDING 122, EMERGENCY MEDICAL SERVICES, AND BUILDING 123, HEALTH PHYSICS LABORATORY. BUILDING 441, THE PRODUCTION ... - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  15. 53. VIEW LOOKING SOUTHWEST FROM THE CLARK AVENUE BRIDGE. REPUBLIC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. VIEW LOOKING SOUTHWEST FROM THE CLARK AVENUE BRIDGE. REPUBLIC SPRAWLS ALONG 798 ACRES ON BOTH SIDES OF THE CUYAHOGA RIVER. IN THE DISTANCE, AT CENTER, BLAST FURNACES NOs. 5 AND 6 AND THE PLANT'S UPPER DOCK CAN BE SEEN. VERTICAL LEFT BRIDGE, IN FOREGROUND, CONNECTS BLAST FURNACES NOs. 1 AND 4 WITH THE STEEL FURNACE AND ROLLING MILL. - Corrigan, McKinney Steel Company, 3100 East Forty-fifth Street, Cleveland, Cuyahoga County, OH

  16. 7. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION WITH SEVENTH STREET. THE PLANT WAS BUILT ON THE SITE WITH FOUR SEPARATE PRODUCTION AREAS, AND AN ADMINISTRATION AND SUPPORT AREA. THIS PHOTOGRAPH SHOWS THE EASTERN EDGE OF THE CORE ADMINSTRATION AND SUPPORT AREA, BUILT IN THE EARLY 1950S. IN THE LEFT FOREGROUND OF THE PHOTOGRAPH IS BUILDING 442, USED TO TEST ALL HEPA FILTERS ON SITE. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  17. 6. VIEW LOOKING NORTH ON SIXTH STREET, ACROSS CENTRAL AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW LOOKING NORTH ON SIXTH STREET, ACROSS CENTRAL AVENUE. THE BUILDING ON THE RIGHT IS BUILDING 551, BUILT IN 1953 AS A WAREHOUSE AND METAL FABRICATION SHOP. THE BUILDING ON THE LEFT IS BUILDING 334, ALSO BUILT IN 1953, AS THE ELECTRICAL AND GENERAL MAINTENANCE SHOP. IN THE CENTER OF THE PHOTOGRAPH IN THE BACKGROUND IS BUILDING 374, THE AQUEOUS PROCESS WASTE TREATMENT PLANT. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  18. 8. PARK AVENUE EAST OF CEDAR STREET (400 Block). THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. PARK AVENUE EAST OF CEDAR STREET (400 Block). THE MARCHION HARDWARE BUILDING WAS DESIGNED BY W.W. HISLOP, AND BUILT IN 1895. THE GROUND FLOOR WAS RENOVATED SOME TIME IN THE 1930s. IN THE CENTER IS THE IMPERIAL BLOCK (ca. 1920), AND THE FULLER DRUG COMPANY (1918-1932).THE FULLER SITE WAS OCCUPIED BY THE HIGHLAND THEATER FROM 1932 TO 1972, AND RETAINS MUCH OF THE INTERIOR DECORATION FROM THAT PERIOD - Anaconda Historic District, Park & Commercial Streets, Main Street vicinity, Anaconda, Deer Lodge County, MT

  19. 80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT GUN HILL STATION. 7TH AVENUE EL EXPRESS IS VISIBLE ABOVE THE 3RD AVENUE EL WHICH JOINED ONTO THE SAME STRUCTURE AT GUN HILL ROAD. NOTE: GUN HILL ROAD IS THE NORTH TERMINUS OF THE 3RD AVENUE ELEVATED. TRAINS DID NOT CARRY PASSENGERS BEYOND THIS POINT, ALTHOUGH THE 3RD AVENUE TRACK DID EXTEND FURTHER NORTH FOR SWITCHING PURPOSES AND INTO THE YARDS. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

  20. Fitzsimons General Hospital, Bachelor Officers' Quarters/Officers' Club, West Harlowe Avenue, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Fitzsimons General Hospital, Bachelor Officers' Quarters/Officers' Club, West Harlowe Avenue, South side, 200 feet West of intersection of West Harlow Avenue & South First Street, Aurora, Adams County, CO

  1. 1. MEMORIAL HALL AND COURTHOUSE/LIBRARY EAST FRONT FROM CEDAR AVENUE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. MEMORIAL HALL AND COURTHOUSE/LIBRARY EAST FRONT FROM CEDAR AVENUE, CAMERA FACING WEST. - Lancaster County Center, Memorial Hall & Courthouse/Library, 4845 Cedar Avenue, Lancaster, Los Angeles County, CA

  2. 3. GENERAL VIEW AT 148TH ST. WILLIS AVENUE, 149TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. GENERAL VIEW AT 148TH ST. - WILLIS AVENUE, 149TH ST. STATION. TRANSFER STRUCTURE TO SUBWAY IS LIGHT COLOR BUILDING IN FOREGROUND. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

  3. 2. Copy of early 20th century photograph showing Euclid Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Copy of early 20th century photograph showing Euclid Avenue facade, looking norh. Photograph owned by H.D. Koblitz. - F. B. Stearns Company, Euclid & Lakeview Avenues, Cleveland, Cuyahoga County, OH

  4. Contextual view of building A266 along blake avenue, showing north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building A266 along blake avenue, showing north and west elevations, camera facing southeast. - Mare Island Naval Shipyard, Magazine No. 2, Railroad Avenue, west side near intersection with Imhoff Road, Vallejo, Solano County, CA

  5. 1. General view of underside of AbbeyAvenue branch of the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. General view of underside of Abbey-Avenue branch of the Central viaduct (1886-1888), looking East. This bridge, like the rest of the viaduct, consists of a series of iron and steel spans, supported on iron towers resting on cut-stone foundations. The stairway visible in the photograph led from Scranton Avenue on the valley floor to the bridge deck. - Abbey Avenue Viaduct, Spanning Walworth Valley at Abbey Avenue, Cleveland, Cuyahoga County, OH

  6. PHOTOCOPY OF DRAWING NO. F860, DIVISION AVENUE STATION, EAST ELEVATION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PHOTOCOPY OF DRAWING NO. F-860, DIVISION AVENUE STATION, EAST ELEVATION AND DETAILS, DRAWN BY W.H.C., MAR. 22, 1915. COURTESY OF THE DEPARTMENT OF PUBLIC UTILITIES, DIVISION OF WATER, CITY OF CLEVELAND. - Division Avenue Pumping Station & Filtration Plant, West 45th Street and Division Avenue, Cleveland, Cuyahoga County, OH

  7. 33. 193195 AUBURN AVENUE (Callaway BuildingGeorgia Insurance Brokerage Inc.) (Consolidated ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. 193-195 AUBURN AVENUE (Callaway Building--Georgia Insurance Brokerage Inc.) (Consolidated Mortgage Building--Three Sisters Beauty Shop; Alston & Co. Realty and Property Management) NORTH ELEVATION - 126-255 Auburn Avenue (Commercial Buildings), Auburn Avenue, Atlanta, Fulton County, GA

  8. View of South TwentySixth Street at intersection with Hinckley Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Sixth Street at intersection with Hinckley Avenue. Buildings No. 18, 22, 40, 21, 17, and 16 seen from left to right. Looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  9. View of South TwentyEighth Street at intersection with Foothill Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Eighth Street at intersection with Foothill Avenue. Seen from Buildings No. 44, 45, 47, and 41 from left to right. Looking south - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  10. View of Hinkley Avenue at intersection with South TwentyEighth Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue at intersection with South Twenty-Eighth Street. Buildings No. 14, 11, 12, 13, 16, and 17 from left to right. Looking west - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  11. View of Foothill Avenue at intersection with South TwentyEighth Street ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Foothill Avenue at intersection with South Twenty-Eighth Street at right. Buildings No. 41, 38, 40, 42, and 43 from left to right. Looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  12. View of intersection of Foothill Avenue and South TwentySixth Street ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of intersection of Foothill Avenue and South Twenty-Sixth Street seen from South Twenty-Sixth Street. Note Building No. 35 on right, and Buildings No. 37, 38, 40, from left to center rear, looking east - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  13. View of South TwentySixth Street at Foothill Avenue looking at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Sixth Street at Foothill Avenue looking at Cutting Boulevard in center distance, looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  14. Trained immunity: a new avenue for tuberculosis vaccine development.

    PubMed

    Lerm, M; Netea, M G

    2016-04-01

    Adaptive immunity towards tuberculosis (TB) has been extensively studied for many years. In addition, in recent years the profound contribution of innate immunity to host defence against this disease has become evident. The discovery of pattern recognition receptors, which allow innate immunity to tailor its response to different infectious agents, has challenged the view that this arm of immunity is nonspecific. Evidence is now accumulating that innate immunity can remember a previous exposure to a microorganism and respond differently during a second exposure. Although the specificity and memory of innate immunity cannot compete with the highly sophisticated adaptive immune response, its contribution to host defence against infection and to vaccine-induced immunity should not be underestimated and needs to be explored. Here, we present the concept of trained immunity and discuss how this may contribute to new avenues for control of TB. PMID:26602369

  15. Ignored avenues in alpha-synuclein associated proteopathy.

    PubMed

    Chowhan, Rimpy K; Mittal, Shruti; Dar, Tanveer A; Kamal, Mohammad A; Singh, Laishram R

    2014-01-01

    Alpha-Synuclein (αSyn) is a 14 kDa pre-synaptic protein predominantly expressed in various regions of brain comprising neocortex, hippocampus, striatum, thalamus and cerebellum. αSyn aggregates have special neuropathologic relevance for comprehending Parkinson's disease (PD) and other synucleopathies due to the presence of αSyn aggregates in brain of patients suffering from these diseases. Direct relationship between PD and various single nuclear polymorphisms of αSyn further displays an inherent significance of mutated αSyn in increasing the risk for developing PD. So far, various theories have been emerged to explain αSyn mediated neuronal cell toxicity seen in patients with PD, including interaction of αSyn aggregates with biomolecules, vesicle dystrafficking, augmented oxidative stress, mitochondrial dysfunction, and disruption of synaptic function. Despite the advances in understanding of PD pathophysiology, current available treatments are still aiming at giving symptomatic relief. Lately, PD vaccines against αSyn aggregates are also being considered. However, various other avenues for e.g. post-translational and conformational modifications of αSyn, effect of cellular small molecules such as polyamines and osmolytes on αSyn aggregation, still remain unexplored and we believe that therapeutics directed at these ignored targets will surface as a successful combinational therapy for PD. Additionally, understanding mechanisms behind the interplay between PD and other health conditions, such as Gaucher's disease, Cardiovascular disorders, Hypertension, Homocystinuria, Type-II Diabetes, and Cancer are also speculated to provide great insight for novel therapeutic interventions. In the current review, we have precisely discussed all these ignored avenues with their possible clinical implications. Link between PD and other associated diseases has also been extensively reviewed. PMID:25230221

  16. Avenues of access to future science teachers: An interview study

    NASA Astrophysics Data System (ADS)

    Weiss, Richard

    2007-12-01

    This research study explored the experiences of individuals who chose careers in secondary science education by examining two cohorts of science education students in a teacher credential program and a group of current secondary science teachers in their first five years of teaching. Issues of how these individuals became interested in science education and the characteristics common among them were examined. This study explored the educational experiences that appeared to contribute to people becoming science teachers. This study also explored the participants' motivation and key turning point moments that appeared to contribute to their choice to pursue a career in science education. The research design used in this study was a two-year, semi-structured interview protocol. Research was conducted at one main university site and within one local unified school district. During the 2004-2005 and 2005-2006 academic years, twenty-five secondary science pre-service teacher candidates at a University of California were interviewed, and during the 2005-2006 academic year, twenty-five current practicing science teachers within a Southern California unified school district were also interviewed. Data collection consisted of interviews with the fifty participants typically between 30-45 minutes in length. The EZ-Text software program was employed to aid in the analysis of the transcribed interview data. This study found that much of the previous research on the characteristics of entrants to teaching in general was supported, but that some specific differences exist among science teachers and the general population of teachers. The majority of the participants had exposure to internships or tutoring experiences and indicated that this made them more willing to pursue science teaching as a profession. This study found that high achieving female students constituted the entire female portion of the sample and cited teaching as a friendly avenue for females in science. Teacher

  17. Serial femtosecond crystallography opens new avenues for Structural Biology.

    PubMed

    Coe, Jesse; Fromme, Petra

    2016-01-01

    Free electron lasers (FELs) provide X-ray pulses in the femtosecond time domain with up to 10(12) higher photon flux than synchrotrons and open new avenues for the determination of difficult to crystallize proteins, like large complexes and human membrane proteins. While the X-ray pulses are so strong that they destroy any solid material, the crystals diffract before they are destroyed. The most successful application of FELs for biology has been the method of serial femtosecond crystallography (SFX) where nano or microcrystals are delivered to the FEL beam in a stream of their mother liquid at room temperature, which ensures the replenishment of the sample before the next X-ray pulse arrives. New injector technology allows also for the delivery of crystal in lipidic cubic phases or agarose, which reduces the sample amounts for an SFX data set by two orders of magnitude. Time-resolved SFX also allows for analysis of the dynamics of biomolecules, the proof of principle being recently shown for light-induced reactions in photosystem II and photoactive yellow protein. An SFX data sets consist of thousands of single crystal snapshots in random orientations, which can be analyzed now "on the fly" by data analysis programs specifically developed for SFX, but de-novo phasing is still a challenge, that might be overcome by two-color experiments or phasing by shape transforms. PMID:26786767

  18. Distant view looking west along E. O'Neill Avenue. The side ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Distant view looking west along E. O'Neill Avenue. The side (east) and front (south) of building 257 is in the right foreground. Building 256, 255, 254, and 253 are immediately beyond building 257, with their fronts facing E. O'Neill Avenue. - Fitzsimons General Hospital, Building 257, North side of East O'Neill Avenue, between Tenth & Twelfth Streets, Aurora, Adams County, CO

  19. 53. View looking north along First Street/Dayton Avenue, across covered ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. View looking north along First Street/Dayton Avenue, across covered Dundee Canal prism, toward Botany Worsted Mills - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

  20. 3. VIEW OF SITE A FROM HOOD AVENUE, FACING NORTH/NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF SITE A FROM HOOD AVENUE, FACING NORTH/NORTHWEST. (BUILDINGS 116, 117, 120, 118, 128, AND 122 ARE VISIBLE.) - Fort McPherson, World War II Station Hospital, Structures, Bordered by Hardee & Thorne Avenues & Howe Street, Atlanta, Fulton County, GA

  1. 31. OVERALL VIEW OF COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. OVERALL VIEW OF COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE IN RIGHT FOREGROUND AND ICE HARBOR IN LEFT BACKGROUND. VIEW TO SOUTH. - Dubuque Commercial & Industrial Buildings, Dubuque, Dubuque County, IA

  2. 1. OVERALL VIEW OF DUBUQUE COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. OVERALL VIEW OF DUBUQUE COMMERCIAL/INDUSTRIAL DISTRICT, WITH CENTRAL AVENUE IN CENTER FOREGROUND AND CHICAGO, BURLINGTON AND QUINCY RAILROAD PASSENGER DEPOT IN RIGHT FOREGROUND. VIEW TO NORTH. - Dubuque Commercial & Industrial Buildings, Dubuque, Dubuque County, IA

  3. VIEW OF CHAPEL/ADMINISTRATION BUILDING, WITH CONSTITUTION AVENUE AND “BIVOUAC OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CHAPEL/ADMINISTRATION BUILDING, WITH CONSTITUTION AVENUE AND “BIVOUAC OF THE DEAD” PLAQUES IN FOREGROUND. VIEW TO NORTH. - Los Angeles National Cemetery, 950 South Sepulveda Boulevard, Los Angeles, Los Angeles County, CA

  4. 18. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, BUILT 189x. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. WEST CONFEDERATE AVENUE BRIDGE SPANNING CODON'S RUN, BUILT 189x. NOTE STRAIGHT ASHLAR COURSING AND RAISED KEYSTONES. VIEW NW. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  5. DC66843 VIEW OF THE INDEPENDENCE AVENUE CORRIDOR SPANNED BY THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DC-668-43 VIEW OF THE INDEPENDENCE AVENUE CORRIDOR SPANNED BY THE •DEPARTMENT OF AGRICULTURE BRIDGES, LOOKING WEST FROM TWELFTH STREET, SW - L'Enfant-McMillan Plan of Washington, DC, Washington, District of Columbia, DC

  6. COLUMN DETAIL WITH SUBSTRUCTURE/STEEL BEAM/CONCRETE BEAM AT FIRST AVENUE ONRAMP. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    COLUMN DETAIL WITH SUBSTRUCTURE/STEEL BEAM/CONCRETE BEAM AT FIRST AVENUE ON-RAMP. TRIANGLE BUILDING AT RIGHT SIDE OF PHOTOGRAPH. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

  7. 76 FR 51029 - Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron... Mercury site in Iron Mountain, Dickenson County, Michigan with the following settling parties: The Salvation Army of Wauwatosa, Wisconsin, and the Trinity United Lutheran Church of Iron Mountain,...

  8. 3. EXTERIOR/STREET LEVEL VIEW, LOOKING WEST ALONG FIRST AVENUE NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. EXTERIOR/STREET LEVEL VIEW, LOOKING WEST ALONG FIRST AVENUE NORTH WITH (LEFT TO RIGHT) CALDWELL-MILNER, MCADORY, JOHN HAND, WOODWARD BUILDINGS AND BROWN MARX BUILDING (RIGHT). ALSO PICTURED IS THE BANK FOR SAVINGS BUILDING (TOP RIGHT) AND THE RAILROAD RESERVATION (TOP LEFT TO RIGHT). VIEW TAKEN AS CITY THAWS FROM A MARCH BLIZZARD. - Heaviest Corner on Earth (Commercial), First Avenue, North & Twentieth (20th) Street, North, Birmingham, Jefferson County, AL

  9. Lawrence Livermore National Laboratory East Avenue/Emergency Response Planning Traffic Study

    SciTech Connect

    Schmiegel, T

    2002-02-15

    The Lawrence Livermore National Laboratory (LLNL) and the Sandia National Laboratory (SNL) are located at the eastern end of the City of Livermore. Recently the research facilities have been placed on heightened security alerts due to the events of September 11. To respond to the security concerns, LLNL and SNL have proposed to place East Avenue between South Vasco Road and Greenville Road under administrative control. This type of control would require security check points at both ends of this segment of East Avenue, including a truck inspection facility west of the Greenville Road intersection. In this configuration, East Avenue would be closed to general public traffic. The purpose of this traffic study is to determine the potential traffic impact of placing East Avenue under administrative control. The primary focus of the traffic study is to evaluate the proposed modifications to the geometry and operation of East Avenue between South Vasco Road and Greenville Road. The study also includes a review of a traffic study prepared for the closure of East Avenue in 1989 to determine if the assumptions and conclusions of that study remain valid.

  10. Electric avenues

    SciTech Connect

    Stone, P.; Chang, A.

    1994-12-31

    Highly efficient electric drive technology developed originally for defense applications is being applied to the development of all electric shuttle buses for the San Jose International Airport. An innovative opportunity charging system using induction chargers will be incorporated to extend operation hours. The project, if successful, is expected to reduce pollution at the airport and generate jobs for displaced defense workers.

  11. Investment Avenues

    NASA Astrophysics Data System (ADS)

    Jain, Priyanka

    2012-11-01

    Investors are a heterogeneous group, they may be large or small, rich or poor, expert or lay man and not all investors need equal degree of protection (Mayya, 1996). An investor has three objectives while investing his money, namely safety of invested money, liquidity position of invested money and return on investment. The return on investment may further be divided into capital gain and the rate of return on investment as interest or dividend. Among all investment options available, securities are considered the most challenging as well as rewarding. Securities include shares, debentures, derivatives, units of mutual funds, Government securities etc. An investor may be an individual or corporate legal entity investing funds with a view to derive maximum economic advantage from investment such as rate of return, capital appreciation, marketability, tax advantage and convenience of investment.The Capital market facilitates mobilization of savings of individuals and pools them into reservoir of capital which can be used for the economic development of a country. An efficient capital market is essential for raising capital by the corporate sector of the economy and for the protection of the interest of investors in corporate securities. There arises a need to strike a balance between raising of capital for economic development on one side and protection of investors on the other. Unless the interests of investors are protected, raising of capital, by corporates is not possible. Like, the primary objective of a senior citizenís asset allocation is the generation of regular income.

  12. Improving Critical Thinking Skills Using Learning Model Logan Avenue Problem Solving (LAPS)-Heuristic

    ERIC Educational Resources Information Center

    Anggrianto, Desi; Churiyah, Madziatul; Arief, Mohammad

    2016-01-01

    This research was conducted in order to know the effect of Logan Avenue Problem Solving (LAPS)-Heuristic learning model towards critical thinking skills of students of class X Office Administration (APK) in SMK Negeri 1 Ngawi, East Java, Indonesia on material curve and equilibrium of demand and supply, subject Introduction to Economics and…

  13. VIEW NORTHSOUTH CLINTON AVENUE LEFTBUILDING 10CLINTON STREET STOREHOUSE (1927) CENTERBUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW NORTH-SOUTH CLINTON AVENUE LEFT-BUILDING 10-CLINTON STREET STOREHOUSE (1927) CENTER-BUILDING 35-ELMER STREET WIRE MILL (1899) RIGHT-BUILDING 54-FLAT SHOP 3 A (1924) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  14. 75 FR 76036 - American Axle & Manufacturing Detroit Manufacturing Complex Holbrook Avenue and Saint Aubin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... December 10, 2008 (73 FR 75137). The Department's Notice was amended on January 8, 2009 to clarify that the... (subject firm). The Department's Notice was published in the Federal Register on January 15, 2009 (74 FR... Avenue and Saint Aubin Including On-Site Leased Workers From Paint Tech International Detroit,...

  15. Expanding the Teaching Games for Understanding Model: New Avenues for Future Research and Practice.

    ERIC Educational Resources Information Center

    Holt, Nicholas L.; Strean, William B.; Bengoechea, Enrique Garcia

    2002-01-01

    Reviews research on the Teaching Games for Understanding (TGfU) approach in physical education, noting that many discussions of TGfU have focused on cognitive and psychomotor learning outcomes and neglected the affective domain. An extended TGfU model is presented, suggesting new avenues for future research and practice (e.g., consideration of…

  16. Walnut Springs Interest Unit, Fairmount Avenue School. Primary Unit--Team I.

    ERIC Educational Resources Information Center

    State College Area School District, PA.

    This environmental education teaching guide was designed for primary teachers who may want to develop their own environmental education units or who may wish to integrate the units contained in the guide into their own curriculum. The units in the guide were developed by primary teachers and reflect the experiences of the Fairmont Avenue School…

  17. GAIN: Early Implementation Experiences and Lessons. California's Greater Avenues for Independence Program.

    ERIC Educational Resources Information Center

    Riccio, James; And Others

    California's Greater Avenues for Independence (GAIN) program requires that large numbers of welfare recipients receive job training and preparation for employment. A survey of the program analyzed early operations in 8 of the first 10 counties to implement it; data were gathered from program staff, case records, and field research of the first…

  18. Participation Observation: Chinese Mothers and Children at Rhodes Avenue English Classes.

    ERIC Educational Resources Information Center

    Lenskyj, Helen

    Observations of Chinese mothers and children at Rhodes Avenue (Toronto) English classes and nursery confirm the hypothesis that a high level of parental warmth-support and control tends to become, by Canadian standards, overprotectiveness, and tends to result in a submissive, dependent, over-socialized child. Dependency upon the mother for…

  19. Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues.

    PubMed

    Depp, Colin A; Dev, Sheena; Eyler, Lisa T

    2016-03-01

    Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. Although cognitive impairment is partially independent from mood episodes, depressive symptoms may increase the risk of cognitive impairment in bipolar disorder through inflammatory processes as well as health risks such as obesity and sedentary behavior. Novel treatment avenues at the intersection of bipolar depression and cognitive impairment target inflammation directly or indirectly health behaviors such as diet, physical activity, and sleep hygiene. PMID:26876321

  20. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  1. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  2. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  3. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  4. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Black Rock Channel opposite foot... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning...

  5. 76 FR 22729 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant #1, Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... December 18, 2008 (73 FR 77067). In order to avoid an overlap in worker group coverage, the Department is... Employment and Training Administration Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant 1..., LLC, Power Train Division, Mack Avenue Engine Plant 1, including on-site leased workers of...

  6. Detailed modelling of the wind comfort in a city avenue at the pedestrian level

    NASA Astrophysics Data System (ADS)

    Amorim, J. H.; Valente, J.; Pimentel, C.; Miranda, A. I.; Borrego, C.

    2012-10-01

    The interrelations between microclimatic conditions and urban morphology determine the comfort of pedestrians in a city. This work evaluates the wind comfort, based on international criteria, in a 1.1 km long avenue. For this purpose the CFD model Fluent was applied. 3D virtual simulation domain was constructed from GIS file of the area using a CAD tool. Results show a very complex wind flow in this urban canyon, as a result of its architectural characteristics and relative wind direction. The orientation of the canyon relative to the prevailing wind direction, its configuration (namely its aspect ratio), the presence of tall buildings in the edge of the avenue, and the absence of trees, induce a swirling flow that increases in speed along its length, as a typical channelling effect. As a consequence, comfort conditions are very distinct in the different sections of the avenue. Based on this work, the areas that do not meet the comfort criterion were identified, supporting the implementation of adequate mitigation measures (as natural or artificial windbreakers).

  7. The Copenhagen Accord for limiting global warming: Criteria, constraints, and available avenues

    PubMed Central

    Ramanathan, Veerabhadran; Xu, Yangyang

    2010-01-01

    At last, all the major emitters of greenhouse gases (GHGs) have agreed under the Copenhagen Accord that global average temperature increase should be kept below 2 °C. This study develops the criteria for limiting the warming below 2 °C, identifies the constraints imposed on policy makers, and explores available mitigation avenues. One important criterion is that the radiant energy added by human activities should not exceed 2.5 (range: 1.7–4) watts per square meter (Wm−2) of the Earth's surface. The blanket of man-made GHGs has already added 3 (range: 2.6–3.5) Wm−2. Even if GHG emissions peak in 2015, the radiant energy barrier will be exceeded by 100%, requiring simultaneous pursuit of three avenues: (i) reduce the rate of thickening of the blanket by stabilizing CO2 concentration below 441 ppm during this century (a massive decarbonization of the energy sector is necessary to accomplish this Herculean task), (ii) ensure that air pollution laws that reduce the masking effect of cooling aerosols be made radiant energy-neutral by reductions in black carbon and ozone, and (iii) thin the blanket by reducing emissions of short-lived GHGs. Methane and hydrofluorocarbons emerge as the prime targets. These actions, even if we are restricted to available technologies for avenues ii and iii, can reduce the probability of exceeding the 2 °C barrier before 2050 to less than 10%, and before 2100 to less than 50%. With such actions, the four decades we have until 2050 should be exploited to develop and scale-up revolutionary technologies to restrict the warming to less than 1.5 °C. PMID:20439712

  8. HOT CELL BUILDING, TRA632. CONTEXTUAL VIEW ALONG WALLEYE AVENUE, CAMERA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HOT CELL BUILDING, TRA-632. CONTEXTUAL VIEW ALONG WALLEYE AVENUE, CAMERA FACING EASTERLY. HOT CELL BUILDING IS AT CENTER LEFT OF VIEW; THE LOW-BAY PROJECTION WITH LADDER IS THE TEST TRAIN ASSEMBLY FACILITY, ADDED IN 1968. MTR BUILDING IS IN LEFT OF VIEW. HIGH-BAY BUILDING AT RIGHT IS THE ENGINEERING TEST REACTOR BUILDING, TRA-642. INL NEGATIVE NO. HD46-32-1. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  9. Results of the radiological survey at 16 Yardboro Avenue, Albany, New York (AL137)

    SciTech Connect

    Marley, J.L.

    1987-12-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 16 Yardboro Avenue in Albany, New York was the subject of a radiological investigation initiated May 5, 1986. The residential property consists of a two-story house located on a rectangular lot. An asphalt driveway was on the east side of the house, with broken paving extending to a building at the rear of the lot. A diagram of the property showing the approximate boundaries and the 5-m grid network established for measurements outside the house is shown. The lot included in the radiological survey was /approximately/19 m wide by 35 m deep. Front and rear views of the property are shown. 13 refs., 5 figs., 5 tabs.

  10. Results of the radiological survey at 8 Maplewood Avenue, Colonie, New York (AL180)

    SciTech Connect

    Espegren, M.L.; Marley, J.L.

    1987-12-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminate with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 8 Maplewood Avenue in Colonie, New York was the subject of a radiological investigation initiated July 23, 1986. The residential property consists of a one-story frame house located on a rectangular lot. An asphalt driveway connects the house to the street. A diagram of the property showing the approximate boundaries and the 4-m grid network established for measurements outside the house is shown. The lot included in the radiological survey was /approximately/12 m wide by 35 m deep. Front and rear views of the property are shown. 13 refs., 5 figs., 5 tabs.

  11. Results of the radiological survey at 1110 Central Avenue, Albany, New York (AL215)

    SciTech Connect

    Marley, J.L.; Carrier, R.F.

    1988-02-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1110 Central Avenue in Albany, New York (AL215) was the subject of a radiological investigation initiated May 4, 1987. This commercial property consists of a one-story concrete block office building (Building 1), a one-story concrete block warehouse (Building 2), and four connected storage buildings constructed variously of wood, metal, or concrete block. The structures are situated on an irregularly shaped lot. A diagram of the property showing the approximate boundaries and the 10-m grid network established for measurements outside the buildings is shown. The lot included in the radiological survey was /approximately/45 m wide by 98 m deep. Two views of the property are shown. 13 refs., 6 figs., 5 tabs.

  12. Results of the radiological survey at 7 Maplewood Avenue, Colonie, New York

    SciTech Connect

    Marley, J.L.

    1987-12-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 7 Maplewood Avenue in Colonie, New York, was the subject of a radiological investigation initiated May 8, 1986. The residential property consisted of a house and a garage located on a rectangular lot. An asphalt-paved driveway connected the garage with the street. A diagram of the property showing the approximate boundaries and the 4-m grid network established for measurements outside the house is shown. The lot included in the radiological survey was /approximately/12 m wide by 35.5 m deep. Front and rear views of the property are shown. 13 refs., 5 figs., 5 tabs.

  13. Arc View/Avenue: Coding styles and utility scripts for efficient development

    SciTech Connect

    Ganter, J.

    1996-05-07

    Effectiveness and efficiency of software development can be greatly increased by writing modularized code using informal (styles) and formal (standards) work approaches. Software development is about connecting pieces into a coherent whole. Thus consistent work approaches provide a structure that allows individuals and teams to minimize the time and thought put into making these connections. These investments in structure return even more benefits in the maintenance phase when old code has to be examined by new programmers, or after time has passed. We present some examples of coding style for Avenue: a simplified form of Hungarian notation (notationHungarian, stringCustomerName, etc.), script naming prefixes and suffixes, and options in script headers. We demonstrate several modular, object-like utility scripts that can be used alone or combined into other utilities. These include developer tools such as a System.Echo substitute for Windows, a Window inspector, and a script for detecting and dealing with multiple display resolutions.

  14. Results of the radiological survey at 1052 Central Avenue, Albany, New York (AL208)

    SciTech Connect

    Hall, S.C.; Marley, J.L.

    1987-11-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1052 Central Avenue in Albany, New York, was the subject of a radiological investigation initiated August 26, 1986. The residential property consists of a two-story block and frame house with a separate garage located on a rectangular lot. An asphalt driveway connects the garage to the street. A diagram of the property showing the approximate boundaries and a 6-m grid network established for measurements outside the house is shown. The lot included in the radiological survey was /approximately/17.5 m wide by 43.5 m deep. Front and side views of the property are shown. 13 refs., 5 figs., 5 tabs.

  15. Avenues into Food Planning: A Review of Scholarly Food System Research

    PubMed Central

    Brinkley, Catherine

    2014-01-01

    This review summarizes several avenues of planning inquiry into food systems research, revealing gaps in the literature, allied fields of study and mismatches between scholarly disciplines and the food system life cycle. Planners and scholars in associated fields have identified and defined problems in the food system as ‘wicked’ problems, complex environmental issues that require systemic solutions at the community scale. While food justice scholars have contextualized problem areas, planning scholars have made a broad case for planning involvement in solving these wicked problems while ensuring that the functional and beneficial parts of the food system continue to thrive. This review maps the entry points of scholarly interest in food systems and planning’s contributions to its study, charting a research agenda for the future. PMID:24932131

  16. From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system.

    PubMed

    Ueno, Norikiyo; Lodoen, Melissa B

    2015-08-01

    Infection of the central nervous system (CNS) is a significant cause of morbidity and mortality, and treatments available to combat the highly debilitating symptoms of CNS infection are limited. The mechanisms by which pathogens in the circulation overcome host immunity and breach the blood-brain barrier are active areas of investigation. In this review, we discuss recent work that has significantly advanced our understanding of the avenues of pathogen dissemination to the CNS for four eukaryotic pathogens of global health importance: Toxoplasma gondii, Plasmodium falciparum, Trypanosoma brucei, and Cryptococcus neoformans. These studies highlight the remarkable diversity of pathogen strategies for trafficking to the brain and will ultimately contribute to an improved ability to combat life-threatening CNS disease. PMID:26048316

  17. Results of the radiological survey at 136 West Central Avenue (MJ030), Maywood, New Jersey

    SciTech Connect

    Foley, R.D.; Crutcher, J.W.; Carrier, R.F.; Floyd, L.M.

    1989-02-01

    As a result of the Energy and Water Appropriations Act of Fiscal Year 1984, the property discussed in this report and properties in its vicinity contaminated with residues from the former Maywood Chemical Works (MCW) were included as a decontamination research and development project under the DOE Formerly Utilized Sites Remedial Action Program. As part of this project, DOE is conducting radiological surveys in the vicinity of the site to identify properties contaminated with residues derived from the MCW. The principal radionuclide of concern is thorium-232. The radiological survey discussed in this report is part of that effort and was conducted, at the request of DOE by members of the Measurement Applications and Development Group of Oak Ridge National Laboratory. A radiological survey of the private, residential property at 136 West Central Avenue, Maywood, New Jersey, was conducted during 1987. The survey and sampling of the ground surface and subsurface were carried out on April 29, 1987.

  18. Reproductive delays in mammals: an unexplored avenue for post-copulatory sexual selection.

    PubMed

    Orr, Teri J; Zuk, Marlene

    2014-11-01

    Numerous mammalian taxa exhibit reproductive delays, pauses in reproduction that occur between mating and fertilization, between fertilization and implantation of the embryo, or after an embryo has implanted. Of the 27 mammalian orders, 9 are known to exhibit reproductive delays, including Diptrotodontia, Dasyuromorphia, Eulipotyphyta, Cingulata, Carnivora, Rodentia, Chiroptera, Lagomorpha and Cetartiodactyla. Most researchers interested in delays have focused on their evolutionary origins. However, the consequences of these delays have not been considered fully. Given the lengthening of the period over which reproduction occurs, it is possible that this unique aspect of reproduction facilitates post-copulatory sexual selection. When considered in the context of sexual selection, delays may allow sperm competition and female manipulation of fertilization (cryptic female choice) as well as other post-copulatory processes. We investigate the potential for reproductive delays to facilitate post-copulatory sexual selection and suggest avenues for research that may further our knowledge of sexual selection. We also provide a general review of reproductive delays in mammals. PMID:24517909

  19. New avenues to heavy right-handed neutrinos with pair production at hadronic colliders

    NASA Astrophysics Data System (ADS)

    Kang, Zhaofeng; Ko, P.; Li, Jinmian

    2016-04-01

    In many models incorporating the type-I seesaw mechanism, the right-handed neutrino (N ) couples to heavy vector/scalar bosons and thereby has resonant pair production. It has barely received attention thus far; however, it may provide the best avenue to probe TeV scale N without requiring anomalously large mixing between N and the active neutrino νL . In this paper we explore the discovery prospects of (mainly heavy) N pair production at the 14 TeV LHC and future 100 TeV p p collider, based on the three signatures: (1) trilepton from N (→ℓWℓ)N (→ℓWh) with Wℓ/h being the leptonically/hadronically decaying W ; (2) boosted di-Higgs boson plus ET from N (→νLh )N (→νLh ) ; (3) a single boosted Higgs boson with leptons and ET from N (→ℓWℓ)N (→νLh ) . At the 100 TeV collider, we also consider the situation when the Higgs boson is overboosted, thus losing its jet substructure. Interpreting our tentative results in the benchmark model, the local B -L model, we find that the (multi-) TeV scale N can be probed at the (100) 14 TeV colliders.

  20. Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

    PubMed Central

    Tobe, Ryuta; Carlson, Bradley A.; Tsuji, Petra A.; Lee, Byeong Jae; Gladyshev, Vadim N.; Hatfield, Dolph L.

    2015-01-01

    A common characteristic of many cancer cells is that they suffer from oxidative stress. They, therefore, require effective redox regulatory systems to combat the higher levels of reactive oxygen species that accompany accelerated growth compared to the normal cells of origin. An elevated dependence on these systems in cancers suggests that targeting these systems may provide an avenue for retarding the malignancy process. Herein, we examined the redox regulatory systems in human liver and lung cancers by comparing human lung adenocarcinoma and liver carcinoma to their respective surrounding normal tissues. Significant differences were found in the two major redox systems, the thioredoxin and glutathione systems. Thioredoxin reductase 1 levels were elevated in both malignancies, but thioredoxin was highly upregulated in lung tumor and only slightly upregulated in liver tumor, while peroxiredoxin 1 was highly elevated in lung tumor, but downregulated in liver tumor. There were also major differences within the glutathione system between the malignancies and their normal tissues. The data suggest a greater dependence of liver on either the thioredoxin or glutathione system to drive the malignancy, while lung cancer appeared to depend primarily on the thioredoxin system. PMID:26569310

  1. Paradoxical thinking as a new avenue of intervention to promote peace.

    PubMed

    Hameiri, Boaz; Porat, Roni; Bar-Tal, Daniel; Bieler, Atara; Halperin, Eran

    2014-07-29

    In societies involved in an intractable conflict, there are strong socio-psychological barriers that contribute to the continuation and intractability of the conflict. Based on a unique field study conducted in the context of the Israeli-Palestinian conflict, we offer a new avenue to overcome these barriers by exposing participants to a long-term paradoxical intervention campaign expressing extreme ideas that are congruent with the shared ethos of conflict. Results show that the intervention, although counterintuitive, led participants to express more conciliatory attitudes regarding the conflict, particularly among participants with center and right political orientation. Most importantly, the intervention even influenced participants' actual voting patterns in the 2013 Israeli general elections: Participants who were exposed to the paradoxical intervention, which took place in proximity to the general elections, reported that they tended to vote more for dovish parties, which advocate a peaceful resolution to the conflict. These effects were long lasting, as the participants in the intervention condition expressed more conciliatory attitudes when they were reassessed 1 y after the intervention. Based on these results, we propose a new layer to the general theory of persuasion based on the concept of paradoxical thinking. PMID:25024185

  2. Results of the radiological survey at 1155-57 Central Avenue, Colonie, New York (AL216)

    SciTech Connect

    Marley, J.L.; Carrier, R.F.

    1988-02-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1155-57 Central Avenue in Colonie, New York was the subject of a radiological investigation initiated May 7, 1987. This commercial property consists of two separate buildings on an asphalt and concrete-paved lot. A diagram of the property showing the approximate boundaries and the 8-m grid network established for measurements outside the buildings is shown. The larger of the two buildings, Building 1, has been constructed in sections that vary in size, number of levels (1 or 2), and basic materials (frame, concrete block, or meal). Building 2 is a one-story metal structure. The rectangular lot included in the survey was /approximately/33 m wide by 75 deep. Front and rear views of the property are shown. 13 refs., 5 figs., 5 tabs.

  3. Diagnosis of Endometrial-Factor Infertility: Current Approaches and New Avenues for Research

    PubMed Central

    Katzorke, N.; Vilella, F.; Ruiz, M.; Krüssel, J.-S.; Simón, C.

    2016-01-01

    Over the last decade, research to improve success rates in reproductive medicine has focused predominantly on the understanding and optimization of embryo quality. However, the emergence of personalized medicine in ovulation induction and embryology has shifted the focus to assessing the individual status of the endometrium. The endometrium is considered receptive during an individually defined period, the window of implantation (WOI), when the mother permits a blastocyst to attach and implant. This individual receptivity status can now be objectively diagnosed using the endometrial receptivity array (ERA) developed in 2011. The ERA, together with a computational algorithm, detects the unique transcriptomic signature of endometrial receptivity by analyzing 238 differentially expressed genes and reliably predicting the WOI. We and others have illustrated the utility of this personalized diagnostic approach to discriminate between individual physiological variation in endometrial receptivity and unknown endometrial pathology, deemed as causal in recurrent implantation failure (RIF). An international randomized controlled trial (“The ERA as a diagnostic guide for personalized embryo transfer.” ClinicalTrials.gov Identifier: NCT01954758) is underway to determine the clinical value of this endometrial diagnostic intervention in the work-up for reproductive care. In this review, we analyse the current clinical practice in the diagnosis of the endometrial factor together with new avenues of research. PMID:27365540

  4. Ring expansion reactions of anti-aromatic boroles: a promising synthetic avenue to unsaturated boracycles.

    PubMed

    Barnard, Jonathan H; Yruegas, Sam; Huang, Kexuan; Martin, Caleb D

    2016-08-21

    Conjugated boron heterocycles have emerged as attractive synthetic targets due to their potential in medicinal chemistry and as electronic materials. However, the development of unsaturated boracycles has been hampered by difficulties in their preparation. Recently, a new synthetic avenue to access these species has been developed that takes advantage of the high reactivity of boroles. These five-membered anti-aromatic heterocycles can react with substrates to furnish ring expansion products via the insertion of one, two, or three atoms into the boracyclic ring. The ring expansion can occur via two pathways, the first exploits the activated diene moiety of the heterocycle in Diels-Alder chemistry with the resulting bicyclic species undergoing further rearrangements. The second reaction pathway is initiated by the coordination of the Lewis basic site of a substrate to the highly Lewis acidic boron center rendering the endocyclic B-C bond of the borole nucleophilic, inducing the formation of larger boracycles via attack at the electrophilic site of the substrate. This review summarizes the current state of this chemistry and details the mechanisms leading to the products. The methodologies described herein could very well be extended to other substrates, as well as applied to other anti-aromatic heterocycles. PMID:27345619

  5. New avenues for treating emotional memory disorders: towards a reconsolidation intervention for posttraumatic stress disorder

    PubMed Central

    Kindt, Merel; van Emmerik, Arnold

    2016-01-01

    The discovery that fear memories may change upon retrieval, a process referred to as memory reconsolidation, opened avenues to develop a revolutionary new treatment for emotional memory disorders. Reconsolidation is a two-phase process in which retrieval of a memory initiates a transient period of memory destabilization, followed by a protein synthesis-dependent restabilization phase. This reconsolidation window offers unique opportunities for amnesic agents to interfere with the process of memory restabilization, thereby weakening or even erasing the emotional expression from specific fear memories. Here we present four uncontrolled case descriptions of patients with symptoms of posttraumatic stress disorder (PTSD) who received a reconsolidation intervention. The intervention basically involves a brief reactivation of the trauma memory aimed to trigger memory destabilization, followed by the intake of one pill of 40 mg propranolol HCl (i.e. a noradrenergic beta-blocker) that should disrupt the process of memory restabilization. We present three cases who showed a steep decline of fear symptoms after only one or two intervention sessions. To illustrate that the translation from basic science to clinical practice is not self-evident, we also present a description of a noneffective intervention in a relatively complex case. Even though the reconsolidation intervention is very promising, the success of the treatment depends on whether the memory reactivation actually triggers memory reconsolidation. Obviously the uncontrolled observations described here warrant further study in placebo-controlled designs. PMID:27536348

  6. Vascular Toxicities of Cancer Therapies: The Old and the New - An Evolving Avenue.

    PubMed

    Herrmann, Joerg; Yang, Eric H; Iliescu, Cezar A; Cilingiroglu, Mehmet; Charitakis, Konstantinos; Hakeem, Abdul; Toutouzas, Konstantinos; Leesar, Massoud A; Grines, Cindy L; Marmagkiolis, Konstantinos

    2016-03-29

    Since the late 1990s, there has been a steady decline in cancer-related mortality, in part related to the introduction of so-called targeted therapies. Intended to interfere with a specific molecular pathway, these therapies have, paradoxically, led to a number of effects off their intended cancer tissue or molecular targets. The latest examples are tyrosine kinase inhibitors targeting the Philadelphia Chromosome mutation product, which have been associated with progressive atherosclerosis and acute vascular events. In addition, agents designed to interfere with the vascular growth factor signaling pathway have vascular side effects ranging from hypertension to arterial events and cardiomyocyte toxicity. Interestingly, the risk of cardiotoxicity with drugs such as trastuzumab is predicted by preexisting cardiovascular risk factors and disease, posing the question of a vascular component to the pathophysiology. The effect on the coronary circulation has been the leading explanation for the cardiotoxicity of 5-fluorouracil and may be the underlying the mechanism of presentation of apical ballooning syndrome with various chemotherapeutic agents. Classical chemotherapeutic agents such as cisplatin, often used in combination with bleomycin and vinca alkaloids, can lead to vascular events including acute coronary thrombosis and may be associated with an increased long-term cardiovascular risk. This review is intended to provide an update on the evolving spectrum of vascular toxicities with cancer therapeutics, particularly as they pertain to clinical practice, and to the conceptualization of cardiovascular diseases, as well. Vascular toxicity with cancer therapy: the old and the new, an evolving avenue. PMID:27022039

  7. Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation

    PubMed Central

    McKee, Robert A.; Wingert, Rebecca A.

    2016-01-01

    Recent research has shown that fully developed organs can be decellularized, resulting in a complex scaffold and extracellular matrix (ECM) network capable of being populated with other cells. This work has resulted in a growing field in bioengineering focused on the isolation, characterization, and modification of organ derived acellular scaffolds and their potential to sustain and interact with new cell populations, a process termed reseeding. In this review, we cover contemporary advancements in the bioengineering of kidney scaffolds including novel work showing that reseeded donor scaffolds can be transplanted and can function in recipients using animal models. Several major areas of the field are taken into consideration, including the decellularization process, characterization of acellular and reseeded scaffolds, culture conditions, and cell sources. Finally, we discuss future avenues based on the advent of 3D bioprinting and recent developments in kidney organoid cultures as well as animal models of renal genesis. The ongoing mergers and collaborations between these fields hold the potential to produce functional kidneys that can be generated ex vivo and utilized for kidney transplantations in patients suffering with renal disease. PMID:27375844

  8. Results of the radiological survey at 108 Avenue E, Lodi, New Jersey (LJ084)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-06-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally /sup 232/Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 108 Avenue E, Lodi, New Jersey (LJ084), was conducted during 1988. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs., 2 figs., 2 tabs.

  9. Results of the radiological survey at 99 Garibaldi Avenue, Lodi, New Jersey (LJ064)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.; Crutcher, J.W.

    1989-07-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally /sup 232/Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 99 Garibaldi Avenue, Lodi, New Jersey (LJ064), was conducted during 1987. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 4 refs., 8 figs., 3 tabs.

  10. Results of the radiological survey at 90 C Avenue, Lodi, New Jersey (LJ079)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-06-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducted an investigative radiological survey during 1988 at 90 C Avenue, Lodi, New Jersey (LJ079), one of the properties in the vicinity of the MCW site. The survey included a gamma radiation scan of the surface and at one meter above the surface, as well as radionuclide sampling of surface and subsurface soil. The survey objective was to determine whether this site was contaminated with radioactive residues derived from MCW, principally /sup 232/Th. Results of the survey demonstrated radionuclide concentrations in excess of DOE remedial action criteria, primarily from the /sup 232/Th decay chain, with some contamination from /sup 226/Ra. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs., 3 figs., 3 tabs.

  11. Results of the radiological survey at 113 Avenue E, Lodi, New Jersey (LJ081)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-06-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally /sup 232/Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 113 Avenue E, Lodi, New Jersey (LJ081), was conducted during 1988. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs, 2 figs., 3 tabs.

  12. Paradoxical thinking as a new avenue of intervention to promote peace

    PubMed Central

    Hameiri, Boaz; Porat, Roni; Bar-Tal, Daniel; Bieler, Atara; Halperin, Eran

    2014-01-01

    In societies involved in an intractable conflict, there are strong socio-psychological barriers that contribute to the continuation and intractability of the conflict. Based on a unique field study conducted in the context of the Israeli–Palestinian conflict, we offer a new avenue to overcome these barriers by exposing participants to a long-term paradoxical intervention campaign expressing extreme ideas that are congruent with the shared ethos of conflict. Results show that the intervention, although counterintuitive, led participants to express more conciliatory attitudes regarding the conflict, particularly among participants with center and right political orientation. Most importantly, the intervention even influenced participants' actual voting patterns in the 2013 Israeli general elections: Participants who were exposed to the paradoxical intervention, which took place in proximity to the general elections, reported that they tended to vote more for dovish parties, which advocate a peaceful resolution to the conflict. These effects were long lasting, as the participants in the intervention condition expressed more conciliatory attitudes when they were reassessed 1 y after the intervention. Based on these results, we propose a new layer to the general theory of persuasion based on the concept of paradoxical thinking. PMID:25024185

  13. Invited commentary: Personality phenotype and mortality--new avenues in genetic, social, and clinical epidemiology.

    PubMed

    Chapman, Benjamin P

    2013-09-01

    In this issue of the Journal, Jokela et al. (Am J Epidemiol. 2013;178(5):667-675) scrutinize the association between personality phenotype and all-cause mortality in remarkable detail by using an "individual-participant meta-analysis" design. Across 7 large cohorts varying in demographics and methods of personality measurement, they find varying prospective associations for 4 dimensions of the five-factor (or "Big Five") model of personality, but robust and consistent prospective associations for Big Five dimension of "conscientiousness." Jokela et al. place an important exclamation point on a long era of study of this topic and hint directly and indirectly at new avenues for this line of research. I consider the following 3 areas particularly rife for further inquiry: the role of genetics in personality and health studies; the role of personality in social inequalities in health; and the health policy and clinical implications of work like that of Jokela et al., including the potential role of personality phenotype in the evolution of personalized medicine. PMID:23911611

  14. 78 FR 19195 - RH International, LLC, 2531 West Maryland Avenue, Tampa, FL 33629, Respondent, Mohammad Reza (a/k...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ..., the most recent being that of August 15, 2012 (77 FR 49699, August 16, 2012), has continued the..., Respondent, Mohammad Reza (a/k/a Ray) Hajian, 2531 West Maryland Avenue, Tampa, FL 33629, Related Person.../a ``Ray'') Hajian (``Hajian'') is the owner and operator of RH International. Hajian pled...

  15. 75 FR 11916 - Chrysler Group LLC, Formerly Known as Chrysler LLC, Conner Avenue Assembly Plant, Including On...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... known as Chrysler, LLC, Conner Avenue Assembly Plant, Detroit, Michigan. The notice was published in the Federal Register on November 5, 2009 (74 FR 57337). At the request of the State Agency, the Department... Assembly Plant, Including On-Site Leased Workers From Aerotek, CDI, Syncreon and Caravan Knight...

  16. GAIN: Program Strategies, Participation Patterns, and First-Year Impacts in Six Counties. California's Greater Avenues for Independence Program.

    ERIC Educational Resources Information Center

    Riccio, James; Friedlander, Daniel

    The first findings of an evaluation of California's welfare-to-work program, Greater Avenues for Independence (GAIN), related to its impact on employment, earnings, and welfare payments. The impact results came from a study of applicants for and recipients of Aid to Families with Dependent Children (AFDC) in six counties and were limited to the…

  17. 78 FR 19194 - P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... being that of August 15, 2012 (77 FR 49699 (August 16, 2012)), has continued the Regulations in effect... Bureau of Industry and Security P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying... Division, P&P Computers (``P&P'') was convicted of violating the International Emergency Economic...

  18. 76 FR 27366 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plants #1 And #2, Including On-Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... notice was published in the Federal Register on April 22, 2011 (76 FR 22731). The notice was amended on..., 2011 (76 FR 22729). At the request of a company official, the Department reviewed the certification for... Employment and Training Administration Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plants...

  19. Viral ecology of organic and inorganic particles in aquatic systems: avenues for further research

    PubMed Central

    Weinbauer, M.G.; Bettarel, Y.; Cattaneo, R.; Luef, B.; Maier, C.; Motegi, C.; Peduzzi, P.; Mari, X.

    2016-01-01

    Viral abundance and processes in the water column and sediments are well studied for some systems; however, we know relatively little about virus–host interactions on particles and how particles influence these interactions. Here we review virus–prokaryote interactions on inorganic and organic particles in the water column. Profiting from recent methodological progress, we show that confocal laser scanning microscopy in combination with lectin and nucleic acid staining is one of the most powerful methods to visualize the distribution of viruses and their hosts on particles such as organic aggregates. Viral abundance on suspended matter ranges from 105 to 1011 ml−1. The main factors controlling viral abundance are the quality, size and age of aggregates and the exposure time of viruses to aggregates. Other factors such as water residence time likely act indirectly. Overall, aggregates appear to play a role of viral scavengers or reservoirs rather than viral factories. Adsorption of viruses to organic aggregates or inorganic particles can stimulate growth of the free-living prokaryotic community, e.g. by reducing viral lysis. Such mechanisms can affect microbial diversity, food web structure and biogeochemical cycles. Viral lysis of bacterio- and phytoplankton influences the formation and fate of aggregates and can, for example, result in a higher stability of algal flocs. Thus, viruses also influence carbon export; however, it is still not clear whether they short-circuit or prime the biological pump. Throughout this review, emphasis has been placed on defining general problems and knowledge gaps in virus–particle interactions and on providing avenues for further research, particularly those linked to global change. PMID:27478304

  20. Results of the radiological survey at 110 E Hunter Avenue, Maywood, New Jersey (MJ022)

    SciTech Connect

    Foley, R.D.; Carrier, R.F.; Floyd, L.M.; Crutcher, J.W. )

    1989-09-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 110 E. Hunter Avenue, Maywood, New Jersey (MJ022), was conducted during 1987. Following the removal of a small chunk of material showing elevated gamma exposure rates, all radionuclide concentrations and measurements conformed to DOE remedial action criteria. The slightly elevated radionuclide concentrations found in other soil samples were the result of naturally enhances radioactivity characteristic of some environmental materials such as coal ash and were unrelated to operations at the MCW site. The survey data demonstrate that the property requires no further action on the part of DOE. 4 refs., 2 figs., 3 tabs.

  1. Management of endocrine disease: Cystic fibrosis-related diabetes: novel pathogenic insights opening new therapeutic avenues.

    PubMed

    Barrio, Raquel

    2015-04-01

    Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR). CFTR is primarily present in epithelial cells of the airways, intestine and in cells with exocrine and endocrine functions. Mutations in the gene encoding the channel protein complex (CFTR) cause alterations in the ionic composition of secretions from the lung, gastrointestinal tract, liver, and also the pancreas. CF-related diabetes (CFRD), the most common complication of CF, has a major detrimental impact on pulmonary function, nutrition and survival. Glucose derangements in CF seem to start from early infancy and, even when the pathophysiology is multifactorial, insulin insufficiency is clearly a major component. Consistently, recent evidence has confirmed that CFTR is an important regulator of insulin secretion by islet β-cells. In addition, several other mechanisms were also recognized from cellular and animals models also contributing to either β-cell mass reduction or β-cell malfunction. Understanding such mechanisms is crucial for the development of the so-called 'transformational' therapies in CF, including the preservation of insulin secretion. Innovative therapeutic approaches aim to modify specific CFTR mutant proteins or positively modulate their function. CFTR modulators have recently shown in vitro capacity to enhance insulin secretion and thereby potential clinical utility in CFDR, including synergistic effects between corrector and potentiator drugs. The introduction of incretins and the optimization of exocrine pancreatic replacement complete the number of therapeutic options of CFRD besides early diagnosis and implementation of insulin therapy. This review focuses on the recently identified pathogenic mechanisms leading to CFRD relevant for the development of novel pharmacological avenues in CFRD therapy. PMID:25336504

  2. Results of the radiological survey at the Niagara-Mohawk property, Railroad Avenue, Colonie, New York (AL218)

    SciTech Connect

    Marley, J.L.; Carrier, R.F.

    1987-12-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The Niagara-Mohawk property on Railroad Avenue in Colonie, New York, was the subject of a radiological investigation initiated June 11, 1987. This commercial property is an irregularly shaped lot partially occupied by an electric power substation and associated transmission lines. Portions of the property that were swampy and heavily vegetated were inaccessible to the survey team. There are no buildings on the property. A diagram showing the approximate boundaries and the 15-m grid network established for measurements on the property is shown. The lot included in the radiological survey was /approximately/45 m wide by 246 m deep. Two views of the property are shown. 13 refs., 6 figs., 4 tabs.

  3. The Potential of GIS as a Management Tool for Avenue Trees Population in Small Communities; a Case Study of Idi-Shin Community, Ibadan, Nigeria

    NASA Astrophysics Data System (ADS)

    Olokeogun, O. S.; Akintola, O. O.; Abodunrin, E. K.

    2016-06-01

    This study demonstrates the potentials of Geographic Information System (GIS) as a management tool for avenue trees (Street trees) populations in small communities (using Idi-Ishin community, Ibadan, Nigeria as a case study). GIS is a decision support system which integrate data or set of data from different sources, bringing them under the same referencing system in a computer system. An Ikonos Imagery (1m Spatial Resolution) of the study area was digitized to produce a digital map using ArcGIS 10.1 version. The avenue trees species ≥ 5cm diameter at breast height (DBH) was selected for enumeration. These trees were then measured and tagged. The Height, Girth and Geographic location (X &Y coordinate) of the trees were measured with Haga altimeter, Girthing tape and Hand held Global Positioning System (GPS) respectively. The species and families of the trees enumerated were also identified. Data were analysed for basal area (BA) and volume (V). A total number of 43 avenue trees were assessed in Idi-Ishin Community. Roystonea regia accounted for the majority of the avenue trees (25.58%), followed by Polyanthia longiflora (23.26%), Gliricida seprium (20.93%), Eucalyptus toreliana (13.95%), Delunix regea (6.98%). However Terminalia catapa, Terminalia radii, Azadrachita indica and Newbodia levis had the same abundance of 2.33%. It was also observed that the benefits derived from these avenue trees includes; Carbon sequestration, Beautification, Wind break and shade. A spatial relational database was created for the assessed avenue trees using ArcCatalog of ArcGIS 10.1 version. Based on the findings from the study (which serves as baseline information for the management of the avenue trees in the study area), it was therefore recommended that subsequent assessment should be carried out at 3-5 year interval in other to ensure proper and continuous monitoring and updating of the data.

  4. Avenues to Inspiration

    ERIC Educational Resources Information Center

    Campbell, Ashley

    2011-01-01

    Integrating the worlds of art and science can be a perfect tool for engaging students who wouldn't be initially interested in a science class. Even those students who love science may delve deeper into the subject when it's associated with art. One way to make this connection is to explore the life and work of great nature artists of the past and…

  5. Radiological assessment and remedial action report for the ''Son of Lansdowne'' property, 186 North Lansdowne Avenue, Lansdowne, Pennsylvania

    SciTech Connect

    Smith, W.H.; Wynveen, R.A.

    1987-08-01

    This document reports the results of a radiological assessment and remedial action program conducted by Argonne National Laboratory personnel at a radioactively contaminated private residence in Lansdowne, Pennsylvania. The program was conducted on the residence at 186 Lansdowne Avenue. The survey conducted by the ANL personnel indicated that several dozen areas or spots of contamination were present on all floors and the basement of the three-story house. Contamination was found on furniture, carpeting, walls, floors, woodwork, and ceilings. Remedial action undertaken to remove the contamination ranged from scrubbing, to scraping, to shaving of wood, to removal and disposal of items and material that could not be adequately decontaminated. Outdoors, contaminated soil was removed from the backyard, and the driveway was dug up so the contaminated subsurface material could be removed. The remedial action generated quantities of radioactive waste, including four 55-gallon drums and one M-III bin (120 ft/sup 3/) containing floor tile, concrete, personal items, furniture, floor scrapings, vermiculite absorbed scrub water, and other items. In addition, there were 24 M-III bins containing approximately 112 tons of contaminated soil and rock from the two contaminated areas in the backyard and from the contaminated subsurface of the driveway. 2 refs., 39 figs., 12 tabs.

  6. Public health assessment for Plymouth Avenue Landfill, Deland, Volusia County, Florida, Region 4. Cerclis No. FLD984167569. Final report

    SciTech Connect

    Not Available

    1994-08-24

    The Plymouth Avenue Landfill is about 1.75 miles west of the City of DeLand in rural western Volusia County, Florida. From 1971 to 1988 it was a Class I landfill and received all types of nonhazardous industrial and municipal solid waste. From June 1978 to October 1980, the landfill reportedly received 4,500 gallons per week of process waste slurry from the Brunswick Corporation. The authors selected the following contaminants of concern: barium, chromium, 1,2-dichloroethene, iron, nitrate, sulfate, and vinyl chloride. Ingestion of ground water is a past completed human exposure pathway. Concentrations of the contaminants of concern found so far are unlikely to have caused illness in the nearby residents. Analysis of water samples has been inadequate, however, to assess the public health threat from ingestion of sulfate, giardia, or vinyl chloride. Based on the information currently available, the authors classify the public health hazard at this landfill as indeterminate. Groundwater sampling is needed to determine the extent of vinyl chloride contamination.

  7. A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

    PubMed Central

    Wu, Liangcai; Xu, Qianqian; Zhang, Haohai; Li, Ming; Zhu, Chengpei; Jiang, Minjie; Sang, Xinting; Zhao, Yi; Sun, Qiang; Zhao, Haitao

    2016-01-01

    Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition, and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding–non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage, and DNA repair. Kaplan–Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored. PMID:27539025

  8. 77 FR 27082 - StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ... December 28, 2010, applicable to workers and former workers of StarTek USA, Inc., Greeley, Colorado. The Department's notice of determination was published in the Federal Register on January 14, 2011 (76 FR 2717... Employment and Training Administration StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA,...

  9. GAIN in the Community Colleges: A Report on the 1990-91 Survey on Participants and Funding in the Greater Avenues for Independence Program.

    ERIC Educational Resources Information Center

    Hill, Jim

    Created in 1985, the Greater Avenues for Independence (GAIN) program is a comprehensive effort by the state of California to provide education, employment, and support services to help welfare recipients enter the workforce. California's GAIN is now part of the national Job Opportunities and Basic Skills (JOBS) program, established in 1988. In…

  10. Influence of avenue-trees on air quality at the urban neighborhood scale. Part I: quality assurance studies and turbulent Schmidt number analysis for RANS CFD simulations.

    PubMed

    Gromke, Christof; Blocken, Bert

    2015-01-01

    Flow and dispersion of traffic pollutants in a generic urban neighborhood with avenue-trees were investigated with Computational Fluid Dynamics (CFD). In Part I of this two-part contribution, quality assessment and assurance for CFD simulations in urban and vegetation configurations were addressed,before in Part II flow and dispersion in a generic urban neighborhood with multiple layouts of avenue trees were studied. In a first step, a grid sensitivity study was performed that inferred that a cell count of 20 per building height and 12 per canyon width is sufficient for reasonable grid insensitive solutions. Next, the performance of the realizable k-ε turbulence model in simulating urban flows and of the applied vegetation model in simulating flow and turbulence in trees was validated. Finally, based on simulations of street canyons with and without avenue-trees, an appropriate turbulent Schmidt number or modeling dispersion in the urban neighborhood was determined as Sc(t) =0.5. PMID:25463716

  11. Influence of avenue-trees on air quality at the urban neighborhood scale. Part II: traffic pollutant concentrations at pedestrian level.

    PubMed

    Gromke, Christof; Blocken, Bert

    2015-01-01

    Flow and dispersion of traffic-emitted pollutants were studied in a generic urban neighborhood for various avenue-tree layouts by employing 3D steady RANS simulations with the realizable k-ε turbulence model. In comparison to the tree-free situation quantitative and qualitative changes with flow reversal in the wind field were observed. Low to moderate increases (<13.2%) in the neighborhood-averaged pollutant concentration were found at pedestrian level. An approximately 1% increase in the neighborhood-averaged concentration was obtained with each percent of the street canyon volumes being occupied by vegetation for occupation fractions between 4 and 14%. The overall pattern of concentration changes relative to the tree-free situation was similar for all avenue-tree layouts. However, pronounced locally restricted decreases or increases in concentration (-87 to +1378%) occurred. The results indicate the necessity to account for existing or planned avenue-trees in neighborhood scaled is dispersion studies. Their consideration is prerequisite for reliable urban air quality assessment. PMID:25463712

  12. Defibrillation at a football stadium: an experiment with Brighton and Hove Albion

    PubMed Central

    Jaggarao, N S V; Sless, H; Grainger, R; Vincent, R; Chamberlain, D A

    1982-01-01

    Over a five-year period arrangements have been made to increase the prospects of resuscitation for victims of sudden death at a large football stadium. Seven cases of ventricular fibrillation occurred. Four were resuscitated successfully and were subsequently discharged from hospital. PMID:6805564

  13. 76 FR 37807 - Albion Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... project) to be located on the Blackstone River, in the Town of Cumberland, in Providence County, Rhode... Atlantic utility pole number 31-1 in Cumberland, Rhode Island; and (6) fish passage/protection...

  14. Results of the radiological survey of State of New York land between 80--110 Yardboro Avenue, Albany, New York (AL151)

    SciTech Connect

    Hall, S.C.; Marley, J.L.

    1987-12-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property between 80--110 Yardboro Avenue, Albany, New York, was the subject of a radiological investigation initiated June 8, 1986. The property consists of a vacant parcel with not structures on a rectangular lot. A concrete slab extends onto the lot from the property to the east. A diagram of the property showing the approximate boundaries and the 20-m grid network established for measurements are shown. The rectangular area included in the radiological survey was /approximately/120 m wide by 34 m deep. Two views of the property are shown. The red brick building partially showing in the background is the former NL Industries Plant. 13 refs., 6 figs., 4 tabs.

  15. Superfund Record of Decision (EPA Region 2): Mannheim Avenue Dump site, Galloway Township, Atlantic County, NJ. (First remedial action), September 1990. Final report

    SciTech Connect

    Not Available

    1990-09-27

    The 2-acre Mannheim Avenue Dump site is a former municipally-owned industrial waste landfill in Galloway Township, Atlantic County, New Jersey. Surrounding land use is rural residential, and many residents and facilities in the area use ground water as their drinking water supply. Beginning in 1964, drummed industrial wastes, including TCE degreasing sludge, leaded porcelain fragments, and municipal waste, were buried onsite in 35 waste mounds. In 1982, a State survey indicated the presence of many unburied and leaking drums onsite. Sampling from 1985 to 1986, revealed ground water contamination onsite. In 1989, 35 mounds of contaminated soil were disposed of offsite. The Record of Decision (ROD) addresses ground water contamination at the site. The primary contaminants of concern affecting the ground water are VOCs including benzene and TCE.

  16. Acacia Avenue and Coronation Street

    ERIC Educational Resources Information Center

    Rees, Christopher; Edmunds, Philip Turnbull

    1971-01-01

    Summarizes some of the more significant findings from a survey of two socially and economically disparate areas in Nottinghamshire, and calls for a less limited approach to university adult education in Britain. (Editor/AN)

  17. Genomic Avenue to Avian Colisepticemia

    PubMed Central

    Huja, Sagi; Oren, Yaara; Trost, Eva; Brzuszkiewicz, Elzbieta; Biran, Dvora; Blom, Jochen; Goesmann, Alexander; Gottschalk, Gerhard; Hacker, Jörg

    2015-01-01

    ABSTRACT Here we present an extensive genomic and genetic analysis of Escherichia coli strains of serotype O78 that represent the major cause of avian colisepticemia, an invasive infection caused by avian pathogenic Escherichia coli (APEC) strains. It is associated with high mortality and morbidity, resulting in significant economic consequences for the poultry industry. To understand the genetic basis of the virulence of avian septicemic E. coli, we sequenced the entire genome of a clinical isolate of serotype O78—O78:H19 ST88 isolate 789 (O78-9)—and compared it with three publicly available APEC O78 sequences and one complete genome of APEC serotype O1 strain. Although there was a large variability in genome content between the APEC strains, several genes were conserved, which are potentially critical for colisepticemia. Some of these genes are present in multiple copies per genome or code for gene products with overlapping function, signifying their importance. A systematic deletion of each of these virulence-related genes identified three systems that are conserved in all septicemic strains examined and are critical for serum survival, a prerequisite for septicemia. These are the plasmid-encoded protein, the defective ETT2 (E. coli type 3 secretion system 2) type 3 secretion system ETT2sepsis, and iron uptake systems. Strain O78-9 is the only APEC O78 strain that also carried the regulon coding for yersiniabactin, the iron binding system of the Yersinia high-pathogenicity island. Interestingly, this system is the only one that cannot be complemented by other iron uptake systems under iron limitation and in serum. PMID:25587010

  18. Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

    PubMed Central

    2012-01-01

    With 24.3 million people affected in 2005 and an estimated rise to 42.3 million in 2020, dementia is currently a leading unmet medical need and costly burden on public health. Seventy percent of these cases have been attributed to Alzheimer’s disease (AD), a neurodegenerative pathology whose most evident symptom is a progressive decline in cognitive functions. Dual specificity tyrosine phosphorylation regulated kinase-1A (DYRK1A) is important in neuronal development and plays a variety of functional roles within the adult central nervous system. The DYRK1A gene is located within the Down syndrome critical region (DSCR) on human chromosome 21 and current research suggests that overexpression of DYRK1A may be a significant factor leading to cognitive deficits in people with Alzheimer’s disease (AD) and Down syndrome (DS). Currently, treatment options for cognitive deficiencies associated with Down syndrome, as well as Alzheimer’s disease, are extremely limited and represent a major unmet therapeutic need. Small molecule inhibition of DYRK1A activity in the brain may provide an avenue for pharmaceutical intervention of mental impairment associated with AD and other neurodegenerative diseases. We herein review the current state of the art in the development of DYRK1A inhibitors. PMID:23173067

  19. First study on anthropogenic Pt, Pd, and Rh levels in soils from major avenues of São Paulo City, Brazil.

    PubMed

    Ribeiro, A P; Figueiredo, A M G; Sarkis, J E S; Hortellani, M A; Markert, B

    2012-12-01

    Over the last years, investigations on the increase of platinum (Pt), palladium (Pd), and rhodium (Rh) levels in urban environments of big cities all over the world - especially to catalytic converters emissions - have been grown up enormously. São Paulo City is the 6th largest megacity in the world having about 20 million inhabitants and an ever increasing seven million motor vehicle fleet. In spite of this, there has never been an investigation regarding Pt, Pd, and Rh levels in the city. In the present study, Pt, Pd, and Rh concentrations were determined in soils adjacent to seven main high-density traffic avenues in the metropolitan region of São Paulo City. Inductively coupled plasma mass spectrometry was employed - after ultrasound-assisted aqua regia leaching - as analytical technigue. The results showed concentration levels up to 378 ng g(-1) for Pd, 208 ng g(-1) for Pt, and 0.2 to 45 ng g(-1) for Rh. These levels are much higher than those considered for the geochemical background of soils, indicating a catalytic converter source. Due to the different Pt/Pd/Rh ratio in Brazilian automobile catalytic converters, lower levels of Pt/Pd ratios compared with other similar studies were observed. The obtained results are the first data for monitoring Pt, Pd, and Rh pollution in São Paulo City soils. PMID:22322405

  20. Results of the radiological survey at the Firemen's Memorial Park and Fire Hall No. 2, Garibaldi Avenue and Kennedy Drive, Lodi, New Jersey (LJ066)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.; Crutcher, J.W. )

    1989-08-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of the gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, the Firemen's Memorial Park and Fire Hall 2, Garibaldi Avenue and Kennedy Drive, Lodi, New Jersey (LJ066) was conducted during 1987. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 4 refs., 10 figs., 3 tabs.

  1. Three-dimensional visualization maps of suspended-sediment concentrations during placement of dredged material in 21st Avenue West Channel Embayment, Duluth-Superior Harbor, Duluth, Minnesota, 2015

    USGS Publications Warehouse

    Groten, Joel T.; Ellison, Christopher A.; Mahoney, Mollie H.

    2016-01-01

    Excess sediment in rivers and estuaries poses serious environmental and economic challenges. The U.S. Army Corps of Engineers (USACE) routinely dredges sediment in Federal navigation channels to maintain commercial shipping operations. The USACE initiated a 3-year pilot project in 2013 to use navigation channel dredged material to aid in restoration of shoreline habitat in the 21st Avenue West Channel Embayment of the Duluth-Superior Harbor. Placing dredged material in the 21st Avenue West Channel Embayment supports the restoration of shallow bay aquatic habitat aiding in the delisting of the St. Louis River Estuary Area of Concern.The U.S. Geological Survey, in cooperation with the USACE, collected turbidity and suspended-sediment concentrations (SSCs) in 2014 and 2015 to measure the horizontal and vertical distribution of SSCs during placement operations of dredged materials. These data were collected to help the USACE evaluate the use of several best management practices, including various dredge material placement techniques and a silt curtain, to mitigate the dispersion of suspended sediment.Three-dimensional visualization maps are a valuable tool for assessing the spatial displacement of SSCs. Data collection was designed to coincide with four dredged placement configurations that included periods with and without a silt curtain as well as before and after placement of dredged materials. Approximately 230 SSC samples and corresponding turbidity values collected in 2014 and 2015 were used to develop a simple linear regression model between SSC and turbidity. Using the simple linear regression model, SSCs were estimated for approximately 3,000 turbidity values at approximately 100 sampling sites in the 21st Avenue West Channel Embayment of the Duluth-Superior Harbor. The estimated SSCs served as input for development of 12 three-dimensional visualization maps.

  2. Varroa destructor: research avenues towards sustainable control

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A recent review article about sustainable control of Varroa mites implies that little progress has been made in developing and applying honey bees that have genetic resistance to mites. Here we explain some of the successes that have resulted from research into genetic resistance In sum, we suggest ...

  3. Future Avenues to Decrease Uremic Toxin Concentration.

    PubMed

    Vanholder, Raymond C; Eloot, Sunny; Glorieux, Griet L R L

    2016-04-01

    In this article, we review approaches for decreasing uremic solute concentrations in chronic kidney disease and in particular, in end-stage renal disease (ESRD). The rationale to do so is the straightforward relation between concentration and biological (toxic) effect for most toxins. The first section is devoted to extracorporeal strategies (kidney replacement therapy). In the context of high-flux hemodialysis and hemodiafiltration, we discuss increasing dialyzer blood and dialysate flows, frequent and/or extended dialysis, adsorption, bioartificial kidney, and changing physical conditions within the dialyzer (especially for protein-bound toxins). The next section focuses on the intestinal generation of uremic toxins, which in return is stimulated by uremic conditions. Therapeutic options are probiotics, prebiotics, synbiotics, and intestinal sorbents. Current data are conflicting, and these issues need further study before useful therapeutic concepts are developed. The following section is devoted to preservation of (residual) kidney function. Although many therapeutic options may overlap with therapies provided before ESRD, we focus on specific aspects of ESRD treatment, such as the risks of too-strict blood pressure and glycemic regulation and hemodynamic changes during dialysis. Finally, some recommendations are given on how research might be organized with regard to uremic toxins and their effects, removal, and impact on outcomes of uremic patients. PMID:26500179

  4. Migraine: current therapeutic targets and future avenues.

    PubMed

    Arulmozhi, D K; Veeranjaneyulu, A; Bodhankar, S L

    2006-04-01

    Migraine is characterized by attacks of intense pulsatile and throbbing headache, typically unilateral in nature with or without aura. Migraine affects a substantial fraction (10-20 %) of the world population (more women than men). With regard to the pathophysiology of migraine, several theories have been proposed; the major three are vascular (due to cerebral vasodilatation), neurological (abnormal neurological firing) and neurogenic dural inflammation (release of inflammatory neuropeptides). The drugs used to treat migraine can be divided into two groups: agents that abolish the acute migraine headache and agents aimed at prevention. The acutely acting antimigraine agents (5-HT(1B/1D) receptor agonists) stimulated research interest in the field of migraine. Currently prophylactic treatments for migraine include calcium channel blockers, 5-HT(2) receptor antagonists, beta-adrenoceptor blockers and gamma-amino butyric acid (GABA) agonists. Unfortunately, many of these treatments are non-specific and not always effective. Despite progress, the complex etiology of migraine requires further research, the condition often remains undiagnosed and available therapies are underused. In this review, the evidence that linked the different theories of migraine with its pathophysiology is considered. Furthermore, the present therapeutic targets and future approaches for the acute and prophylactic treatment of migraine are critically evaluated. PMID:16611154

  5. Creating New Avenues for CTE Teacher Development.

    ERIC Educational Resources Information Center

    Szuminski, Kathleen A.

    2002-01-01

    A model program for onsite teacher development to prepare and retain exemplary career and technical education teachers was designed to meet the needs of new teachers who came from industry backgrounds. Core elements include partnership with business- industry and universities and ongoing support for teaching strategies. (JOW)

  6. Alphabet Avenue: Wordplay in the Fast Lane.

    ERIC Educational Resources Information Center

    Morice, Dave

    This collection of palindromes, pangrams, acrostics, word squares and word ladders, visual and numerical puzzles, silly names, and much more is designed to delight, surprise, and challenge both the novice and the expert player of word games. It uses the metaphor of a busy, cosmopolitan city to showcase three facets of words: forms of letters,…

  7. Varroa destructor: research avenues towards sustainable control

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pollination by honeybees plays a key role in the functioning of ecosystems and optimization of agricultural yields. Severe honeybee colony losses worldwide have raised concerns about the sustainability of these pollination services. In most cases, bee morbidity appears to be the product of many inte...

  8. Avenues for rehabilitation of auricular defects.

    PubMed

    Nanda, Aditi; Jain, Veena; Kabra, Sri Krishna

    2012-01-01

    Irrespective of the cause, abnormalities in shape, size, and position of body organs are often perceived as looking wrong. This perception can subject the individual to significant peer ridicule and social ostracism. Rehabilitation of patients with auricular defects can either be done by reconstructive surgery or by prosthetic means. The article draws a comparison between the implant-supported prosthesis and reconstructive surgery, listing the benefits, limitations, indications and contraindications of both the techniques. As both the available techniques give excellent results in appropriately selected situations, the restorative team must present all the alternatives to the patient and choose judiciously the better of the two. PMID:22842256

  9. Sialylation: an Avenue to Target Cancer Cells.

    PubMed

    Vajaria, Bhairavi N; Patel, Kinjal R; Begum, Rasheedunnisa; Patel, Prabhudas S

    2016-07-01

    Tumorigenesis and metastasis are frequently associated with altered structure and expression of oligosaccharides on cell surface glycoproteins and glycolipids. The expression of sialylated glycoconjugates has been shown to change during development, differentiation, disease and oncogenic transformation. Abnormal sialylation in cancer cell is a distinctive feature associated with malignant properties including invasiveness and metastatic potential. The alterations in sialylation is accompanied by changes in sialic acid, sialidase activity, sialyltransferase (ST) activity or sialoproteins. The present review summarizes the reports on alterations of sialic acid, linkage specific STs and sialoproteins, sialidase activity together with different subtypes of ST and sialidases mRNA expressions in various cancers like lung, breast, oral, cervical, ovarian, pancreatic etc. Sialic acids are widely distributed in nature as terminal sugars of oligosaccharides attached to proteins or lipids. The increase shedding of sialic acid observed in malignant tumors may be due to different types of sialidases. The amount of sialic acid is governed by levels of sialidases and STs. Various types of STs are also involved in formation of different types sialylated tumor associated carbohydrate antigens which plays important role in metastasis. The alterations associated with sialylation aids in early diagnosis, prognosis and post treatment monitoring in various cancers. Recently newer drugs targeting different interplays of sialylation have been developed, which might have profound effect in inhibiting sialylation and thus cancer metastasis and infiltration. PMID:26685886

  10. Additional insights. Commentary on “the musical stroop effect: opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

    PubMed

    Akiva-Kabiri, Lilach; Henik, Avishai

    2014-01-01

    In their paper "The Musical Stroop Effect: Opening a New Avenue to Research on Automatisms," Grégoire, Perruchet, and Poulin-Charronnat (2013) use a musical Stroop-like task to demonstrate the automaticity of musical note naming in musicians. In addition, the authors suggest that music training can serve as a tool in order to study the acquisition of automaticity. In the following commentary, we aim to address three main issues concerning the paper by Grégoire et al. (2013). First, we will suggest some additional interpretations of the results; specifically, we will relate to the association between music and space. Second, we will discuss a methodological issue dealing with interference, facilitation, and the role of the neutral condition. We suggest that the study by Grégoire et al. (2013) lacks a proper neutral condition and thus it is impossible to assert that the congruency effect is interference based. Third, we will discuss the authors' suggestion of using the musical Stroop effect as a tool for studying automatism. We consider the practical relevance of music training as a tool for studying the acquisition of automaticity by pointing out that music training is highly heterogeneous. PMID:24449650

  11. Guide to Pre-Planning. A Guide to be Used in Preparation of Classes Attending Albion Hills Conservation Field Centre or Claremont Conservation Field Centre. Revised Edition.

    ERIC Educational Resources Information Center

    Snell, Blanche E.

    The purpose of this pre-planning guide is to assist those in charge of classes in residence that attend the Conservation Field Center during the school week. The guide provides necessary details on clothing, spending money, health and safety, the role of the parent, duties and housekeeping rules, daily time schedules and programs. It is noted that…

  12. 76 FR 52687 - Notice of Intent To Prepare a Resource Management Plan (RMP) Amendment and Associated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Associated Environmental Assessment for the Castle Rocks and Cedar Fields Areas, Burley Field Office, ID... 1976, as amended, the Bureau of Land Management (BLM) Burley Field Office, Burley, Idaho intends to... pertinent to this proposal may be examined at the Burley Field Office. FOR FURTHER INFORMATION...

  13. Advancements and Avenues in Nanophytomedicines for Better Pharmacological Responses.

    PubMed

    Saraf, Swarnlata; Gupta, Anshita; Alexander, Amit; Khan, Junaid; Jangde, Manmohan; Saraf, Shailendra

    2015-06-01

    Novel drugs delivery systems (NDDS), formulations from plant actives and extracts are still a matter of thrust and hot cake among the researchers working with phytomedicine. Novel delivery systems such as polymeric liposomes, colloidisomes, aquasomes, ethosomes, niosomes, proliposomes, phytosomes, nanoparticles, nanocapsules, nanoemulsions, microsphere and transferosomes have been proven to be a better carrier for delivery of the phyto-constituents as already done by various eminent scientists. Due to increased bioavailability, protection from toxicity, enhancement of pharmacological activity, enhancement of stability, improved tissue macrophages distribution, sustained delivery, and protection from physical and chemical degradation novel delivery systems are more suitable delivery system in compare to the conventional systems. This articled, highlight the remarkable findings in the recent past by innovators exclusively working on novel drug delivery systems for phyto-constituents. PMID:26369014

  14. Towards new avenues in the management of lupus glomerulonephritis.

    PubMed

    Mok, C C

    2016-04-01

    Renal involvement in systemic lupus erythematosus (SLE) carries substantial morbidity and mortality. Conventional immunosuppressive agents (cyclophosphamide and azathioprine) have suboptimal efficacy and substantial toxicity. Mycophenolate mofetil has emerged as an alternative agent for both induction and maintenance therapy in lupus nephritis because of its reduced gonadal toxicity, despite its failure to demonstrate superiority over cyclophosphamide in pivotal studies. The calcineurin inhibitor tacrolimus has equivalent efficacy to cyclophosphamide and mycophenolate mofetil for inducing remission of lupus nephritis. Although rituximab has shown promise in refractory lupus nephritis, combining rituximab with mycophenolate mofetil as initial therapy offers no additional benefit. Considerable interethnic variation is evident in the efficacy and tolerability of the various immunosuppressive regimens, which necessitates individualized treatment and comparison of the efficacy of new regimens across different ethnic groups. For example, low-dose combinations of tacrolimus and mycophenolate mofetil seem to be more effective than pulse cyclophosphamide as induction therapy in Chinese patients. The same regimen has also been used successfully to treat refractory proliferative and membranous lupus nephritis in patients of various ethnic groups. Finally, novel serum and urinary biomarkers are being validated for diagnosis, prognostic stratification and early recognition of flares in lupus nephritis. PMID:26729459

  15. New avenues for anti-epileptic drug discovery and development.

    PubMed

    Löscher, Wolfgang; Klitgaard, Henrik; Twyman, Roy E; Schmidt, Dieter

    2013-10-01

    Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications fail to control seizures in 20-30% of patients. However, our understanding of the mechanisms mediating the development of epilepsy and the causes of drug resistance has grown substantially over the past decade, providing opportunities for the discovery and development of more efficacious anti-epileptic and anti-epileptogenic drugs. In this Review we discuss how previous preclinical models and clinical trial designs may have hampered the discovery of better treatments. We propose that future anti-epileptic drug development may be improved through a new joint endeavour between academia and the industry, through the identification and application of tools for new target-driven approaches, and through comparative preclinical proof-of-concept studies and innovative clinical trials designs. PMID:24052047

  16. Gorgias on Madison Avenue: Sophistry and the Rhetoric of Advertising.

    ERIC Educational Resources Information Center

    Matcuk, Matt

    Using sophistic theory and focusing on intersections in the practice and reception of sophistry and advertising, a study analyzed a contemporary advertising campaign. A number of extrinsic similarities between sophistic and advertising rhetoric exist: their commercial basis, their popular reception as dishonest speech, and the reception of both as…

  17. New avenues for phase matching in nonlinear hyperbolic metamaterials.

    PubMed

    Duncan, C; Perret, L; Palomba, S; Lapine, M; Kuhlmey, B T; de Sterke, C Martijn

    2015-01-01

    Nonlinear optical processes, which are of paramount importance in science and technology, involve the generation of new frequencies. This requires phase matching to avoid that light generated at different positions interferes destructively. Of the two original approaches to achieve this, one relies on birefringence in optical crystals, and is therefore limited by the dispersion of naturally occurring materials, whereas the other, quasi-phase-matching, requires direct modulation of material properties, which is not universally possible. To overcome these limitations, we propose to exploit the unique dispersion afforded by hyperbolic metamaterials, where the refractive index can be arbitrarily large. We systematically analyse the ensuing opportunities and demonstrate that hyperbolic phase matching can be achieved with a wide range of material parameters, offering access to the use of nonlinear media for which phase matching cannot be achieved by other means. With the rapid development in the fabrication of hyperbolic metamaterials, our approach is destined to bring significant advantages over conventional techniques for the phase matching of a variety of nonlinear processes. PMID:25757863

  18. Youth Sport Programs: An Avenue to Foster Positive Youth Development

    ERIC Educational Resources Information Center

    Fraser-Thomas, Jessica L.; Cote, Jean; Deakin, Janice

    2005-01-01

    Concern about the growth in adolescent problem behaviours (e.g. delinquency, drug use) has led to increased interest in positive youth development, and a surge in funding for "after school programs." We evaluate the potential of youth sport programs to foster positive development, while decreasing the risk of problem behaviours. Literature on the…

  19. Gold-Catalyzed Cyclization Processes: Pivotal Avenues for Organic Synthesis.

    PubMed

    Kumar, Amit; Singh, Sukhdev; Sharma, Sunil K; Parmar, Virinder S; Van der Eycken, Erik V

    2016-02-01

    Over the years, gold catalysis has materialized as an incredible synthetic approach among the scientific community. Due to the trivial reaction conditions and great functional compatibility, these progressions are synthetically expedient, because practitioners can implement them to build intricate architectures from readily amassed building blocks with high bond forming indices. The incendiary growth of gold catalysts in organic synthesis has been demonstrated as one of the most prevailing soft Lewis acids for electrophilic activation of carbon-carbon multiple bonds towards a great assortment of nucleophiles. Nowadays, organic chemists consistently employ gold catalysts to carry out a diverse array of organic transformations to build unprecedented molecular architectures. Despite all these achievements and a plethora of reports, many vital challenges remain. In this account, we describe the reactivity of various gold catalysts towards cyclization processes developed over the years. These protocols give access to a wide scope of polyheterocyclic structures, containing different medium-sized ring skeletons. This is interesting, as the quest for highly selective reactions to assemble diversely functionalized products has attracted much attention. We envisage that these newly developed chemo-, regio-, and diastereoselective protocols could provide an expedient route to architecturally cumbersome heterocycles of importance for the pharmaceutical industry. PMID:26554536

  20. Computers: New Avenues for Engineering Students at the Community College.

    ERIC Educational Resources Information Center

    Brillhart, Lia; Shawhan, Douglas

    At Triton College, student involvement with computers as a continued, multifaceted process is considered a primary objective of the physics and engineering department. To that end, the department implemented a low cost diverse program. The computer uses presented include labs, algorithms, testing, individual projects, drills, graphics, simulation,…

  1. The California fuel cell partnership: an avenue to clean air

    NASA Astrophysics Data System (ADS)

    Lloyd, Alan C.

    The California Fuel Cell Partnership presently consists of eight private companies, two state agencies and a federal government representative that will attempt to demonstrate the feasibility of fuel cell cars and buses. California has attempted to advance the commercialization of zero-emission vehicles for much of the past decade to help the state reduce its high levels of air pollution. A special advisory panel convened by the California Air Resources Board concluded last year that fuel cell technology could meet the key requirements for automobiles. The successful commercialization of fuel cell vehicles would help to reduce the levels of ozone, fine particles and toxic air contaminants that pose health risks to California's population. This technology can also help to reduce carbon dioxide emissions. California regulations now encourage the development of zero and near-zero emission vehicle technologies, including fuel cells. The Fuel Cell Partnership will operate approximately 50 fuel cell cars and buses until the year 2003 in order to produce important information on the vehicles and fueling infrastructure needed to support them.

  2. Experimental Project in Physics Education or New Avenues for Women

    ERIC Educational Resources Information Center

    Pollack, Betty L.; Little, Lee K.

    1973-01-01

    Discusses experience of conducting a project designed to interest and train women in physics, involving student recruitment, course design, laboratory work planning, and counseling services. Included are surveyed faculty and graduate student comments and participants' attitudes toward the project. (CC)

  3. Dietary delivery: A new avenue for microRNA therapeutics?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Many people carefully monitor their food choices, adhering to the philosophy that you are what you eat. Recent research adds to a new wrinkle to that old adage, suggesting that dietary small RNAs (sRNAs) can control the gene expression of the consumer and may provide an effective, noninvasive, and i...

  4. New Project Details Low-Income Schools' Avenues to Success

    ERIC Educational Resources Information Center

    Sawchuk, Stephen

    2008-01-01

    The principal of Noyes Education Campus in the District of Columbia remembers when, in exchange for hefty staff bonuses for outstanding performance, the school hosted a team of visitors armed with video cameras, tape recorders, and piles of interview questions. The focus of their queries: To what did the school attribute its success? What had made…

  5. Avenues of Hope: Art Therapy and the Resolution of Trauma.

    ERIC Educational Resources Information Center

    Appleton, Valerie

    2001-01-01

    Describes a method for using art therapy with adolescents in crisis. The model defines four trauma stages and associated art therapy goals. Presents an example of the model through a case study, including the art therapy approaches and method for assessing the art work and art processes. Proposes that hope is experienced through art and generative…

  6. Neuropathic orofacial pain: cannabinoids as a therapeutic avenue.

    PubMed

    McDonough, Patrick; McKenna, Joseph P; McCreary, Christine; Downer, Eric J

    2014-10-01

    Neuropathic orofacial pain (NOP) exists in several forms including pathologies such as burning mouth syndrome (BMS), persistent idiopathic facial pain (PIFP), trigeminal neuralgia (TN) and postherpetic neuralgia (PHN). BMS and PIFP are classically diagnosed by excluding other facial pain syndromes. TN and PHN are most often diagnosed based on a typical history and presenting pain characteristics. The pathophysiology of some of these conditions is still unclear and hence treatment options tend to vary and include a wide variety of treatments including cognitive behaviour therapy, anti-depressants, anti-convulsants and opioids; however such treatments often have limited efficacy with a great amount of inter-patient variability and poorly tolerated side effects. Analgesia is one the principal therapeutic targets of the cannabinoid system and many studies have demonstrated the efficacy of cannabinoid compounds in the treatment of neuropathic pain. This review will investigate the potential use of cannabinoids in the treatment of symptoms associated with NOP. PMID:25150831

  7. Nanodelivery: An Emerging Avenue for Nutraceuticals and Drug Delivery.

    PubMed

    Aklakur, Md; Asharf Rather, Mohd; Kumar, Neeraj

    2016-10-25

    Aquaculture has been globally recognized as the fastest growing food production sector which plays a major role in meeting the increasing demand for animal protein requirement. A consensus is growing that a dramatic increase in aquaculture is needed to supply future aquatic food needs. However, there are sustained problems with the aquaculture like disease outbreaks, chemical pollution, the environmental destruction, and inefficient feed utilization. These altogether raise question mark on sustainability of aquaculture. In spite of the several strategy adopted on national and international level, as improved laboratory facilities, diagnostic expertise, and control and therapeutic strategies in order to handle disease outbreaks more effectively. Aquaculture industry is under uncertainty and the progress has not matched that of the rapidly developing aquaculture sector. In order to control disease prevalence and ensure better health of system and sustainable production, the sector demand more technical innovation for the drug use, disease treatment, water quality management, production of tailored fish for suiting better health, productivity drive by epigenetic and nutrigenomic interaction, better breeding success by efficient delivery of maturation and spawning inducing agent, nutraceutical delivery for rapid growth promotion and culture time reduction, successful use of autotransgenic, and effective vaccine. Nanotechnology has a tremendous potential to revolutionize agriculture and allied fields including aquaculture and fisheries. For these multiple purposes effort, importance of nanotechnology and nanodelivery of drugs, vaccine, nutraceutical, inducing hormones, and growth-promoting anabolics open tremendous opportunity. The paper has been targeted to delineate the possible future application of nanodelivery for the aquaculture development. PMID:25830230

  8. Review: New diagnostic and therapeutic avenues for mesothelioma.

    PubMed

    Paracha, Usman Zafar; Hayat, Khezar; Ali, Muhammad; Qadir, Muhammad Imran

    2015-07-01

    Mesothelioma is a rare form of cancer affecting the mesothelium lining. It is usually caused by asbestos exposure or exposure to nanofibers. Median survival is less than one year in the mesothelioma patients. Due to its severity, there is a dire necessity to find out new diagnostic and therapeutic strategies. Some recent strategies could help us in fighting against mesothelioma. Diagnostic tools include a range of biomarkers or biotechnological procedure. Therapeutic tools include chemotherapeutic strategies along with immunotherapy, gene therapy and alternative therapy. PMID:26142533

  9. Matrix Metalloproteinases and Minocycline: Therapeutic Avenues for Fragile X Syndrome

    PubMed Central

    Siller, Saul S.; Broadie, Kendal

    2012-01-01

    Fragile X syndrome (FXS) is the most common known genetic form of intellectual disability and autism spectrum disorders. FXS patients suffer a broad range of other neurological symptoms, including hyperactivity, disrupted circadian activity cycles, obsessive-compulsive behavior, and childhood seizures. The high incidence and devastating effects of this disease state make finding effective pharmacological treatments imperative. Recently, reports in both mouse and Drosophila FXS disease models have indicated that the tetracycline derivative minocycline may hold great therapeutic promise for FXS patients. Both models strongly suggest that minocycline acts on the FXS disease state via inhibition of matrix metalloproteinases (MMPs), a class of zinc-dependent extracellular proteases important in tissue remodeling and cell-cell signaling. Recent FXS clinical trials indicate that minocycline may be effective in treating human patients. In this paper, we summarize the recent studies in Drosophila and mouse FXS disease models and human FXS patients, which indicate that minocycline may be an effective FXS therapeutic treatment, and discuss the data forming the basis for the proposed minocycline mechanism of action as an MMP inhibitor. PMID:22685676

  10. Nonsteroidal anti-inflammatory drug gastropathy: new avenues for safety

    PubMed Central

    Roth, Sanford H

    2011-01-01

    Chronic oral or systemic nonselective nonsteroidal anti-inflammatory drug (NSAID) therapy, ubiquitously used by physicians to treat osteoarthritis-associated pain, is associated with a wide range of symptomatic adverse events, the most frequent and serious of which is gastropathy. Although cardiovascular and renal problems are a very real concern, they are significantly less frequent. These complications can be life-threatening in at-risk populations such as older adults, who are common users of long-term oral systemic NSAID therapy. Topical NSAID formulations deliver effective doses of analgesics directly to the affected joints, thereby limiting systemic exposure and potentially the risk of systemic adverse events, such as gastropathy and serious cardiovascular events. There are currently two topical NSAIDs approved by the US Food and Drug Administration for osteoarthritis-associated pain, as well as for the signs and symptoms of osteoarthritis. This review discusses the relative safety, and the gastrointestinal, cardiovascular, and renal risks of chronic oral or systemic NSAID therapy and topical NSAID formulations in patients with osteoarthritis. PMID:21753867

  11. The Role of Women in Television: Avenues for Change.

    ERIC Educational Resources Information Center

    Britton, Helen Ann

    During the 1960's educators became aware that the role models presented by educational materials to minority children helped shape the role that the children ultimately occupied in the society. Similarly, it has been observed that the media presents a negative image of women which may result in unfulfilling role adaptation, a process which becomes…

  12. Avenue T: Using Film as "Entree" in Teaching about Transgender

    ERIC Educational Resources Information Center

    Walters, Andrew S.; Rehma, Kae

    2013-01-01

    Educators from a variety of disciplines include the concept of transgender and multiple gender identities in course curricula. The "T" (denoting the specific inclusion of transgender) in the popular acronym LGBT (lesbian, gay, bisexual, transgender) often is given less pedagogical attention than is sexual orientation, and the transgender…

  13. Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.

    PubMed

    Chevalier, Nina; Tan, Jian K; Mason, Linda J; Robert, Remy; McKenzie, Craig I; Lim, Florence; Wong, Connie H; Macia, Laurence; Thorburn, Alison N; Russ, Brendan E; Masters, Seth L; Mackay, Charles R

    2016-09-01

    Environmental factors contribute to development of autoimmune diseases. For instance, human autoimmune arthritis can associate with intestinal inflammation, cigarette smoking, periodontal disease, and various infections. The cellular and, molecular pathways whereby such remote challenges might precipitate arthritis or flares remain unclear. Here, we used a transfer model of self-reactive arthritis-inducing CD4(+) cells from KRNtg mice that, upon transfer, induce a very mild form of autoinflammatory arthritis in recipient animals. This model enabled us to identify external factors that greatly aggravated disease. We show that several distinct challenges precipitated full-blown arthritis, including intestinal inflammation through DSS-induced colitis, and bronchial stress through Influenza infection. Both triggers induced strong IL-17 expression primarily in self-reactive CD4(+) cells in lymph nodes draining the site of inflammation. Moreover, treatment of mice with IL-1β greatly exacerbated arthritis, while transfer of KRNtg CD4(+) cells lacking IL-1R significantly reduced disease and IL-17 expression. Thus, IL-1β enhances the autoaggressive potential of self-reactive CD4(+) cells, through increased Th17 differentiation, and this influences inflammatory events in the joints. We propose that diverse challenges that cause remote inflammation (lung infection or colitis, etc.) result in IL-1β-driven Th17 differentiation, and this precipitates arthritis in genetically susceptible individuals. Thus the etiology of autoimmune inflammatory arthritis likely relates to diverse triggers that converge to a common pathway involving IL-1β production and Th17 cell distribution. PMID:27427404

  14. DOE ZERH Case Study: Sunroc Builders, Bates Avenue, Lakeland, FL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning affordable home in the hot-humid climate that got HERS 57 without PV, with 6.5” SIP walls and 8.25” SIP roof; uninsulated slab foundation; fresh air intake; SEER 16 ducted air source heat pump.

  15. Dietary delivery: a new avenue for microRNA therapeutics?

    PubMed

    Hirschi, Kendal D; Pruss, Gail J; Vance, Vicki

    2015-08-01

    Many people carefully monitor their food choices, adhering to the philosophy that 'you are what you eat'. Recent research adds a new wrinkle to that old adage, suggesting that dietary small RNAs (sRNAs) can control the gene expression of the consumer and may provide an effective, noninvasive, and inexpensive therapy for many human diseases. PMID:26113189

  16. Avenues to Success--Developing a Thriving Technology Education Program

    ERIC Educational Resources Information Center

    Wynn, Gary

    2008-01-01

    Across the USA, technology education has faced many challenges over the past several decades. Educational changes and reform at all levels seem to have had a positive effect on the required classes or "core" courses. As a result, "elective" courses seem to be delegated to a secondary role in a student's education. In Greenfield-Central High…

  17. Vulnerability and Gambling Addiction: Psychosocial Benchmarks and Avenues for Intervention

    ERIC Educational Resources Information Center

    Suissa, Amnon Jacob

    2011-01-01

    Defined by researchers as "a silent epidemic" the gambling phenomenon is a social problem that has a negative impact on individuals, families and communities. Among these effects, there is exasperating evidence of comprised community networks, a deterioration of family and social ties, psychiatric co-morbidity, suicides and more recently,…

  18. Great Decisions: Low Cost Avenue to Expanded Community

    ERIC Educational Resources Information Center

    Krebs, Virginia

    1974-01-01

    Discussed a program of group discussion, sponsored by the Foreign Policy Association, a New York-based, non-partisan organization for world affairs education, that may have all the features needed to enhance its community service involvement with a minimum of staff and expense. (Author/RK)

  19. Community-Based Education and Rural Development. Site Visit to Nebraska. Rural Funders Working Group Case Study.

    ERIC Educational Resources Information Center

    Doeden, Carol Lee

    In September 2000, grantmakers from around the country traveled to three Nebraska communities--Albion, Crete, and Henderson--to see how community-based education can positively affect the economic, environmental, and cultural development of a rural community. In Albion, the school is an open laboratory in which students, teachers, and parents work…

  20. New avenues in the directed deprotometallation of aromatics: recent advances in directed cupration.

    PubMed

    Harford, Philip J; Peel, Andrew J; Chevallier, Floris; Takita, Ryo; Mongin, Florence; Uchiyama, Masanobu; Wheatley, Andrew E H

    2014-10-14

    Recent advances in the selective deprotometallation of aromatic reagents using alkali metal cuprates are reported. The ability of these synergic bases to effect deprotonation under the influence of a directing group is explored in the context of achieving new and more efficient organic transformations whilst encouraging greater ancillary group tolerance by the base. Developments in our understanding of the structural chemistry of alkali metal cuprates are reported, with both Gilman cuprates of the type R2CuLi and Lipshutz and related cuprates of the type R2Cu(X)Li2 (X = inorganic anion) elucidated and rationalised in terms of ligand sterics. The generation of new types of cuprate motif are introduced through the development of adducts between different classes of cuprate. The use of DFT methods to interrogate the mechanistic pathways towards deprotonative metallation is described. Theoretical modelling of in situ rearrangements undergone by the cuprate base are discussed, with a view to understanding the relationship between R2CuLi and R2Cu(X)Li2, their interconversion and the implications of this for cuprate reactivity. The advent of a new class of adduct between different cuprate types is developed and interpreted in terms of the options for expelling LiX from R2Cu(X)Li2. Applications in the field of medicinal chemistry and (hetero)arene derivatization are explored. PMID:24919957

  1. How In-Training Secondary Education Teachers Think. Avenues for Intervention

    ERIC Educational Resources Information Center

    Perez-Sanchez, Antonio Miguel; Gilar-Corbi, Raquel; Gonzales-Gomez, Carla

    2007-01-01

    Introduction: The aim of this research is to analyse the thinking of teachers-in-training for compulsory secondary education, in order to facilitate the work of education and guidance at secondary schools. Method: The participants were 265 students in the "CAP" program (course for the Pedagogical Aptitude Certificate). The instrument used was a…

  2. A new avenue for high efficiency solar cells: interaction of hot electrons with plasmons (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Kempa, Krzysztof; Naughton, Michael J.

    2015-09-01

    Hot electrons rapidly dissipate their extra free energy, typically into heat. This is the origin of the Shockley-Queisser efficiency limit of the single junction solar cells. An even faster mechanism of electron-plasmon scattering is available in metals. We demonstrate by detailed simulations, that an ultra-thin solar cell with a composite metamaterial/plasmonic collector could yield efficiency exceeding the Shockley-Quasar limit. The composite collector has a double function: firstly, it is designed to participate in efficiently trapping light, and secondly, it is a plasmonic resonator tuned to absorb the energy of hot electrons, thus protecting them from phonon losses.

  3. Heterogeneous reactions of glyoxal on mineral particles: A new avenue for oligomers and organosulfate formation

    NASA Astrophysics Data System (ADS)

    Shen, Xiaoli; Wu, Huihui; Zhao, Yue; Huang, Dao; Huang, Liubin; Chen, Zhongming

    2016-04-01

    Glyoxal (GL) plays a crucial role in the formation of secondary organic aerosols (SOA), because it is highly water soluble and capable of oligomerization. This is the first study to describe irreversible heterogeneous reactions of GL on clean and acidic gas-aged SiO2, α-Al2O3, and CaCO3 particles, as models of real mineral particles, at various relative humidity and without irradiation and gas phase oxidants. A series of products, including oligomers, organosulfates, and organic acids, which contribute to SOA formation, were produced. GL uptake on SO2-aged α-Al2O3 enabled the oxidation of surface S(IV) to S(VI). The presence of adsorbed water on particles favored GL uptake and the formation of oligomers and organosulfate, but it suppressed organic acid formation. In addition, the aging process enhanced the positive effect of adsorbed water on GL uptake. These findings will further our understanding of the GL sink and SOA sources in the atmosphere.

  4. Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier.

    PubMed

    Villa, Carlos H; Pan, Daniel C; Zaitsev, Sergei; Cines, Douglas B; Siegel, Donald L; Muzykantov, Vladimir R

    2015-07-01

    For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics, biodistribution, controlled release and pharmacodynamics. Approaches include encapsulation of drugs within erythrocytes, as well as coupling of drugs onto the red cell surface. This review focuses on the latter approach, and examines the delivery of red blood cell (RBC)-surface-bound anti-inflammatory, anti-thrombotic and anti-microbial agents, as well as RBC carriage of nanoparticles. Herein, we discuss the progress that has been made in surface loading approaches, and address in depth the issues relevant to surface loading of RBC, including intrinsic features of erythrocyte membranes, immune considerations, potential surface targets and techniques for the production of affinity ligands. PMID:26228773

  5. Pseudospectral sampling of Gaussian basis sets as a new avenue to high-dimensional quantum dynamics

    NASA Astrophysics Data System (ADS)

    Heaps, Charles

    This thesis presents a novel approach to modeling quantum molecular dynamics (QMD). Theoretical approaches to QMD are essential to understanding and predicting chemical reactivity and spectroscopy. We implement a method based on a trajectory-guided basis set. In this case, the nuclei are propagated in time using classical mechanics. Each nuclear configuration corresponds to a basis function in the quantum mechanical expansion. Using the time-dependent configurations as a basis set, we are able to evolve in time using relatively little information at each time step. We use a basis set of moving frozen (time-independent width) Gaussian functions that are well-known to provide a simple and efficient basis set for nuclear dynamics. We introduce a new perspective to trajectory-guided Gaussian basis sets based on existing numerical methods. The distinction is based on the Galerkin and collocation methods. In the former, the basis set is tested using basis functions, projecting the solution onto the functional space of the problem and requiring integration over all space. In the collocation method, the Dirac delta function tests the basis set, projecting the solution onto discrete points in space. This effectively reduces the integral evaluation to function evaluation, a fundamental characteristic of pseudospectral methods. We adopt this idea for independent trajectory-guided Gaussian basis functions. We investigate a series of anharmonic vibrational models describing dynamics in up to six dimensions. The pseudospectral sampling is found to be as accurate as full integral evaluation, while the former method is fully general and integration is only possible on very particular model potential energy surfaces. Nonadiabatic dynamics are also investigated in models of photodissociation and collinear triatomic vibronic coupling. Using Ehrenfest trajectories to guide the basis set on multiple surfaces, we observe convergence to exact results using hundreds of basis functions. The pseudospectral sampling of Gaussian basis functions introduces a new and efficient means of calculating the underlying quantum mechanics associated with trajectory-guided basis sets. We also discuss the conceptual connections to the quantum trajectory method and the benefits of solving quantum mechanics on a discrete grid. We include a chapter studying the strengths and weaknesses of the parametric two-electron reduced-density-matrix (p2-RDM) method for systems susceptible to delocalization error. Density matrix methods are known to overestimate the energetic effects of electron delocalization, including severe effects such as diatomic dissociation to fractionally charged atoms. We consider the role of delocalization error in p2-RDM and demonstrate that the p2-RDM is resistant to delocalization error in challenging cases.

  6. Pointing the Way: Possible Avenues of Development in the Field of Mathematics Education

    ERIC Educational Resources Information Center

    Ross, Vicki

    2005-01-01

    An essay review of "Assessing Children's Mathematical Knowledge: Social Class, Sex and Problem Solving" by Barry Cooper and Mirad Dunne, Philadelphia: Open University Press, 2000; "Talking Mathematics in School: Studies in Teaching and Learning," Ed. Magdalene Lampert and Merrie L. Blunk, New York: Teachers College Press, 1998; "Reconstructing…

  7. Public avenues to private spaces: Democratic politics and the control of automobile pollution

    SciTech Connect

    Rajan, S.C.

    1994-01-01

    Automobile pollution policy is an institutional concern because it represents the political problem of addressing one of the ill-effects of mass driving within urban regions. In the United States, where automobility is most pervasive, the social and cultural institutions that make driving an ineluctable feature of everyday life tend to be taken for granted. On the one hand, an idealogy of individualism appears to forestall critical discussion on these aspects within civil society; on the other, reliance on technological solutions and a prevailing culture of interest-group politics help contract the space for normative reasoning within policy discourse. Ironically, though, the more people drive, the more [open quotes]auto[close quotes]-inflicted the problems of air pollution, and the more likely it is that the contradictions of these non-participatory and technocratic forms could generate crises of policy. The predicament of automobile pollution policy then comprises a paralysis in the state's continued capacity to response to what it perceives to be a double-gesture made by its citizens; they demand clean air but are unwilling to take responsibility for achieving it, especially if it involves setting limits on automobile usage. Using both theoretical arguments and empirical and historical evidence from California, this dissertation argues that official readings of automobile pollution control are constricted because they rely on an individualist metaphor which only generates elaborate techniques of risk management in response, thus moving away from a shared public effort towards normative discourse. Yet, it its also critical of approaches that would shift the blame to individual motorists and their vehicles by implying that the problem arises from the employment of a few [open quotes]gross emitters[close quotes] that need to be selectively targeted.

  8. Technology: Student Animation Projects: An Avenue to Promote Creativity and Learning

    ERIC Educational Resources Information Center

    Siegle, Del

    2014-01-01

    Using readily available technology, students of all ages can easily create impressive animated products. Animation allows educators to capitalize on the natural desire that students of all ages hold to tell stories and share their understanding of the world. In the course of planning their animations, students conduct research on topics, organize…

  9. New Avenues of Special Education Resources: Sesame Street Programming for the Exceptional Child.

    ERIC Educational Resources Information Center

    Hayes, LaMarian

    Reviewed are some of the steps taken by Sesame Street staff in developing initial educational television programing for children with retarded development and having mental age of 3 to 5 years old. Three programing objectives are outlined: (1) to make selected elements of Sesame Street's curriculum more comprehensible to mentally retarded (MR)…

  10. Avenues for Scientist Involvement in Planetary Science Education and Public Outreach

    NASA Astrophysics Data System (ADS)

    Shipp, S. S.; Buxner, S.; Cobabe-Ammann, E. A.; Dalton, H.; Bleacher, L.; Scalice, D.

    2012-12-01

    The Planetary Science Education and Public Outreach (E/PO) Forum is charged by NASA's Science Mission Directorate (SMD) with engaging, extending, and supporting the community of E/PO professionals and scientists involved in planetary science education activities in order to help them more effectively and efficiently share NASA science with all learners. A number of resources and opportunities for involvement are available for planetary scientists involved in - or interested in being involved in - E/PO. The Forum provides opportunities for community members to stay informed, communicate, collaborate, leverage existing programs and partnerships, and become more skilled education practitioners. Interested planetary scientists can receive newsletters, participate in monthly calls, interact through an online community workspace, and attend annual E/PO community meetings and meetings of opportunity at science and education conferences. The Forum also provides professional development opportunities on a myriad of topics, from common pre-conceptions in planetary science to program evaluation, to delivering effective workshops. Thematic approaches, such as the Year of the Solar System (http://solarsystem.nasa.gov/yss), are coordinated by the Forum; through these efforts resources are presented topically, in a manner that can be easily ported into diverse learning environments. Information about the needs of audiences with which scientists interact - higher education, K-12 education, informal education, and public - currently is being researched by SMD's Audience-Based Working Groups. Their findings and recommendations will be made available to inform the activities and products of E/PO providers so they are able to better serve these audiences. Also in production is a "one-stop-shop" of SMD E/PO products and resources that can be used in conjunction with E/PO activities. Further supporting higher-education efforts, the Forum coordinates a network of planetary science faculty, bringing them together at science conferences to share resources and experiences and to discuss pertinent education research. An online higher education clearinghouse, (EarthSpace - http://www.lpi.usra.edu/earthspace), has been developed to provide faculty with news and funding information, the latest education research and resources for teaching undergraduates, and undergraduate course materials, including lectures, labs, and homework. The presentation will explore the Planetary Science E/PO Forum pathways and tools available to support scientists involved in - or interested in being involved in - E/PO.

  11. [Media coverage of suicide: From the epidemiological observations to prevention avenues].

    PubMed

    Notredame, Charles-Édouard; Pauwels, Nathalie; Walter, Michel; Danel, Thierry; Vaiva, Guillaume

    2015-12-01

    Media coverage of suicide can result in increased morbi-mortality suicidal rates, due to an imitation process in those who are particularly vulnerable. This phenomenon is known as "Werther effect". Werther effect's magnitude depends on several qualitative and quantitative characteristics of the media coverage, in a dose-effect relationship. An extensive (in terms of audience and history repetition) and salient coverage (glorification of suicide, description of the suicidal method, etc.) increases the risk of contagion. Celebrities' suicide is particularly at risk of Werther effect. Media may also have a preventive role with respect to suicide. Indeed, according to "Papageno effect", journalists could, under certain conditions, help preventing suicide when reporting suicide stories. Two main theories in the field of social psychology have been proposed to account for Werther and Papageno effects: social learning theory and differential identification. Identification of Werther and Papageno effects uncovers new responsibilities and potentialities for the journalists in terms of public health. Their description provides a basis for promising targeted prevention actions. PMID:26358670

  12. Recent Developments in Neurofibromatoses and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues

    PubMed Central

    Rauen, Katherine A.; Huson, Susan M.; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H.; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M.; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H.; Zenker, Martin; Upadhyaya, Meena

    2014-01-01

    Neurofibromatosis type 1 was the first RASopathy and is now one of many RASopathies that are caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Their common underlying pathogenetic etiology causes significant overlap in phenotypic features which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium “Recent Developments in Neurofibromatoses and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues” chronicle this timely and topical clinical translational research symposium. The overarching goal was to bring together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras pathway syndromes to discuss the most state-of-the-art basic science and clinical issues in an effort to spark collaborations directed towards the best practices and therapies for individuals with RASopathies. PMID:25393061

  13. Radiological re-survey results at 146 West Central Avenue, Maywood, New Jersey (MJ034)

    SciTech Connect

    Murray, M.E.; Johnson, C.A.

    1994-05-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from 1916 to 1959. During the early years of operation, MCW stored wastes and residues in low-lying areas west of the processing facilities and consequently some of the residuals containing radioactive materials migrated offsite to the surrounding area. Subsequently, the U.S. Department of Energy (DOE) designated for remedial action the old MCW property and several vicinity properties. Additionally, in 1984, the property at 146 West Central Ave., Maywood, New Jersey and properties in its vicinity were included as a decontamination research and development project under the DOE Formerly Utilized Sites Remedial Action Program. In 1987 and 1988, at the request of DOE, Oak Ridge National Laboratory (ORNL) conducted a radiological survey on this property. A report describing this survey was published in 1989. A second radiological survey by ORNL was conducted on this property in May 1993 at the request of DOE after an ad hoc radiological survey, requested by the property owner and conducted by Bechtel National, Inc. (BNI), identified some contamination not previously found by ORNL. The purpose of the second ORNL survey was to determine whether radioactive materials from the old MCW were present on the property, and if so, if radioactive materials present were above guidelines. A certified civil survey was requisitioned by ORNL to determine actual property boundaries before beginning the radiological re-survey. The re-survey included a surface gamma scan and the collection of a large number of soil samples for radionuclide analyses. Results of this survey demonstrated that although elevated residual thorium-232 contamination was present in a few isolated spots on the southern end of the backyard, it did not exceed DOE guidelines.

  14. Radiological re-survey results at 130 West Central Avenue, Maywood, New Jersey (MJ029)

    SciTech Connect

    Murray, M.E.; Johnson, C.A.

    1994-01-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from 1916 to 1959. During the early years of operation, MCW stored wastes and residues in low-lying areas west of the processing facilities and consequently some of the residuals containing radioactive materials migrated offsite to the surrounding area. Subsequently, the U.S. Department of Energy (DOE), designated for remedial action the old MCW property and several vicinity properties. Additionally, in 1984, the property at 130 West Central Ave., Maywood, New Jersey and properties in its vicinity were included as a decontamination research and development project under the DOE Formerly Utilized Sites Remedial Action Program. In 1987 and 1988, at the request of DOE, ORNL conducted a radiological survey on this property. A second radiological survey by ORNL was conducted on this property in May, 1993 at the request of DOE after an ad hoc radiological survey, requested by a new property owner and conducted by Bechtel National, Inc. (BNI), identified some contamination not previously found by ORNL. The purpose of the survey was to determine if residuals from the old MCW were present on the property, and if so, if any radiological elements present were above guidelines. A certified civil survey was requisitioned by ORNL to determine actual property boundaries before beginning the radiological survey. The radiological re-survey included a surface gamma scan and the collection of a large number of soil samples for radionuclide analyses.

  15. Avenues for Scientist Involvement in Earth and Space Science Education and Public Outreach (Invited)

    NASA Astrophysics Data System (ADS)

    Peticolas, L. M.; Gross, N. A.; Hsu, B. C.; Shipp, S. S.; Buxner, S.; Schwerin, T. G.; Smith, D.; Meinke, B. K.

    2013-12-01

    NASA's Science Mission Directorate (SMD) Science Education and Public Outreach (E/PO) Forums are charged with engaging, extending, supporting, and coordinating the community of E/PO professionals and scientists involved in Earth and space science education activities. This work is undertaken to maximize the effectiveness and efficiency of the overall national NASA science education and outreach effort made up of individual efforts run by these education professionals. This includes facilitating scientist engagement in education and outreach. A number of resources and opportunities for involvement are available for scientists involved in - or interested in being involved in - education or outreach. The Forums provide opportunities for earth and space scientists to stay informed, communicate, collaborate, leverage existing programs and partnerships, and become more skilled education practitioners. Interested scientists can receive newsletters, participate in monthly calls, interact through an online community workspace, and attend E/PO strategic meetings. The Forums also provide professional development opportunities on a myriad of topics, from common pre-conceptions in science, to program evaluation, to delivering effective workshops. Thematic approaches, such as Earth Science Week (http://www.earthsciweek.org), and the Year of the Solar System (http://solarsystem.nasa.gov/yss) are coordinated by the Forums; through these efforts resources are presented topically, in a manner that can be easily ported into diverse learning environments. Information about the needs of audiences with which scientists interact - higher education, K-12 education, informal education, and public - are provided by SMD's Audience-Based Working Groups. Their findings and recommendations are made available to inform the activities and products of E/PO providers so they are able to better serve these audiences. Also available is a 'one-stop shop' of SMD E/PO products and resources that can be used in conjunction with E/PO activities, NASA Wavelength (http://nasawavelength.org). Further supporting higher-education efforts, the Forums coordinate a network of science faculty, bringing them together at science conferences to share resources and experiences and to discuss pertinent education research. An online higher education clearinghouse, EarthSpace (http://www.lpi.usra.edu/earthspace), has been developed to provide faculty with news and funding information, the latest education research and resources for teaching undergraduates, and undergraduate course materials, including lectures, labs, and homework. This presentation will explore the Science E/PO Forums' pathways and tools available to support scientists involved in - or interested in being involved in - E/PO.

  16. The Importance of Acidification in Atopic Eczema: An Underexplored Avenue for Treatment

    PubMed Central

    Panther, David J.; Jacob, Sharon E.

    2015-01-01

    Atopic dermatitis is a form of dermatitis commonly seen in children and adults. Its pathophysiology is complex and is centered on the barrier function of the epidermis. An important aspect of the skin’s barrier is pH, which in turn affects a number of parameters such as the skin flora, protease function, and mediators of inflammation and pruritus. Normal pH for non-neonatal skin is acidic and ranges from 4 to 6. Skin pH in atopic dermatitis patients is often increased into the neutral to basic range, and the resulting cascade of changes contributes to the phenotype of atopic dermatitis. Therefore, the maintenance of normal skin pH remains an important topic in understanding and treating atopic dermatitis. This article will review skin pH and its impact on normal barrier function, pathological pH changes in atopic dermatitis, and the therapeutic considerations related to restoring and maintaining pH balance. PMID:26239459

  17. Assessment of stricturing Crohn's disease: Current clinical practice and future avenues

    PubMed Central

    Bettenworth, Dominik; Nowacki, Tobias M; Cordes, Friederike; Buerke, Boris; Lenze, Frank

    2016-01-01

    Crohn’s disease (CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy (anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of non-invasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. PMID:26811643

  18. Binding of [alpha, alpha]-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design

    SciTech Connect

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P.; Thorn, Katherine J.; Christianson, David W.

    2011-10-21

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of {alpha},{alpha}-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2-methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional {alpha}-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase.

  19. DOE ZERH Case Study: Heirloom Design Build, Euclid Avenue, Atlanta, GA

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning custom home in the mixed-humid climate that got a HERS 50 without PV, with 2x6 16” on center walls with R-19 ocsf; basement with R-28 ccsf, R-5 rigid foam under slab; sealed attic with R-28 ocsf under roof deck; 22.8 SEER; 12.5 HSPF heat pump.

  20. Catalyst free visible light induced cycloaddition as an avenue for polymer ligation.

    PubMed

    Lederhose, Paul; Wüst, Kilian N R; Barner-Kowollik, Christopher; Blinco, James P

    2016-05-21

    The current study introduces a tetrazole species able to perform a rapid, visible light induced nitrile imine-mediated tetrazole-ene cycloaddition (NITEC). Full conversion of the tetrazole species under mild, catalyst free conditions is reported. Importantly, the visible light ligation technology is applied as a method for the modification and ligation of polymers featuring the rapid, clean and exclusive formation of the desired cycloadduct. PMID:27004740

  1. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues.

    PubMed

    Obulesu, M; Rao, Dowlathabad Muralidhara

    2011-01-01

    Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms. These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtisufolia (Sicklepod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), and Salvia officinalis (Garden sage, common sage). PMID:21716802

  2. Art as an Avenue to Science Literacy: Teaching Nanotechnology through Stained Glass

    ERIC Educational Resources Information Center

    Duncan, Kimberly A.; Johnson, Chris; McElhinny, Kyle; Ng, Steve; Cadwell, Katie D.; Zenner Petersen, Greta M.; Johnson, Angela; Horoszewski, Dana; Gentry, Ken; Lisensky, George; Crone, Wendy C.

    2010-01-01

    Nanoscale science and engineering (NSE) and nanotechnology are emerging fields that have captured the attention of scientists and engineers, as well as mainstream media. However, the general public is relatively unaware of NSE, and schools (both K-12 and undergraduate institutions) rarely include nanotechnology as part of their curriculum. To help…

  3. Luminescence dating of interglacial coastal depositional systems: Recent developments and future avenues of research

    NASA Astrophysics Data System (ADS)

    Lamothe, Michel

    2016-08-01

    Luminescence dating offers new opportunities to explore the evolution of Quaternary marine coastal facies and landforms. This review highlights the main advances in luminescence geochronology of interglacial coastal sediments through the analysis of 547 luminescence ages, most of which were published during the last decade. The majority of these reported luminescence investigations have been carried out along passive margin coasts. Since the turn of the century, the discovery of a normalization procedure known as Single Aliquot Regeneration (SAR) has drastically reduced data scatter and improved precision, with the consequence that quartz SAR optically-stimulated luminescence OSL has become the dating protocol of choice for the Last Interglacial (LIG) period. A more complex technique, known as thermally-transferred OSL (TT-OSL), is presumably proposed for dating older interglacials of the Mid-Pleistocene and beyond. Feldspar luminescence is increasingly being applied to dating Pleistocene sea level high stands due to a much higher dose saturation level than quartz OSL. The use of feldspar IRSL (Infrared-stimulated luminescence) is limited by the occurrence of variable, but ubiquitous anomalous fading (AF). Following the advent of AF-correction methods, several Middle Pleistocene sites have been amenable to dating, albeit with significant related uncertainties. Recently, new protocols involving the measurement of post-IR IRSL at elevated temperatures have yielded relatively coherent ages for interglacial sediments up to ca. 300 ka. Quartz OSL/TT-OSL, AF-corrected IRSL, and post-IR IRSL ages are generally correlated with periods of sea level high stands. A few ages are reported from the early and middle part of the Middle Pleistocene, as MIS11, 9 and more commonly MIS7 high stands are documented in strongly uplifting active margin coasts. However, by far the most obvious age peak corresponds to the end of the LIG. The MIS5e shoreline is probably the most studied and luminescence-dated coastal feature of all, as the chronology of the sea level markers is crucial to assess global eustatic sea level variations through the course of the last interglacial. Nevertheless, the observed abundance of young (100-120 ka) luminescence ages for presumed MIS5e sediments may underline methodological issues, and/or reflect the higher preservation potential of late regressive sequences. On the other hand, the occurrence of geographically distant reports of MIS5a high stand might reflect a true eustatic origin for this event. Age analysis supports the impression of general reliability of luminescence for the timing of former sea level high stands. There is a clear need to address issues in dose rate variability, in the phenomenology of fading in feldspar, and in the behaviour of luminescence growth with dose, both in laboratory and natural conditions. These could be addressed and properly evaluated by dating different minerals, as multiple or single grains, with consequent variable internal dose rates. More robust practices in the application of luminescence dating techniques could eventually constrain the age uncertainties to no better than 2-3%. Therefore, the strength of luminescence as a dating tool is more in terms of its extended age range and the ubiquity of datable material.

  4. DOE ZERH Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning production home in the cold climate that got a HERS 38 without PV, with staggered 2x4 studs every 8”on a 2x6 plate with dense-packed R-25 cellulose, basement with 3” XPS exterior and 2: XPS under slab; a vented attic with spray foam top plates and R-60 blown cellulose; 96% AFUE furnace, 14 SEER AC, plus fresh air intake.

  5. Powder-Coated Towpreg: Avenues to Near Net Shape Fabrication of High Performance Composites

    NASA Technical Reports Server (NTRS)

    Johnston, N. J.; Cano, R. J.; Marchello, J. M.; Sandusky, D. A.

    1995-01-01

    Near net shape parts were fabricated from powder-coated preforms. Key issues including powder loss during weaving and tow/tow friction during braiding were addressed, respectively, by fusing the powder to the fiber prior to weaving and applying a water-based gel to the towpreg prior to braiding. A 4:1 debulking of a complex 3-D woven powder-coated preform was achieved in a single step utilizing expansion rubber molding. Also, a process was developed for using powder-coated towpreg to fabricate consolidated ribbon having good dimensional integrity and low voids. Such ribbon will be required for in situ fabrication of structural components via heated head advanced tow placement. To implement process control and ensure high quality ribbon, the ribbonizer heat transfer and pulling force were modeled from fundamental principles. Most of the new ribbons were fabricated from dry polyarylene ether and polymide powders.

  6. Bioinformatics Goes to School—New Avenues for Teaching Contemporary Biology

    PubMed Central

    Wood, Louisa; Gebhardt, Philipp

    2013-01-01

    Since 2010, the European Molecular Biology Laboratory's (EMBL) Heidelberg laboratory and the European Bioinformatics Institute (EMBL-EBI) have jointly run bioinformatics training courses developed specifically for secondary school science teachers within Europe and EMBL member states. These courses focus on introducing bioinformatics, databases, and data-intensive biology, allowing participants to explore resources and providing classroom-ready materials to support them in sharing this new knowledge with their students. In this article, we chart our progress made in creating and running three bioinformatics training courses, including how the course resources are received by participants and how these, and bioinformatics in general, are subsequently used in the classroom. We assess the strengths and challenges of our approach, and share what we have learned through our interactions with European science teachers. PMID:23785266

  7. Avenues of international cooperation in power plants life assessment and management

    SciTech Connect

    Isreb, M.

    1999-11-01

    The present paper examines various attributes, sources of funding and areas of international cooperation in power plants life assessment and management. The attributes discussed in the paper are themes, strategies, benefits and mechanism. Next, the paper focuses on the Australian-American cooperation and sources of funding. In this regard, the paper concentrates on major funding organizations from Australia and the United States such as the Australian Department of Employment, Education, Training and Youth Affairs (DEETYA), the Australian Department of Industry, Science and Tourism (DIST) and the American National Science Foundation (NSF). Finally, the paper presents the area of cooperation in line with the major thrust of the Australian power industry. The paper examines possible subject areas of international cooperation, in relation to efficiency, diversification of fuels and thermal and environmental aspects.

  8. Angiotensin II Receptor Blocker Neprilysin Inhibitor (ARNI): New Avenues in Cardiovascular Therapy.

    PubMed

    Volpe, M; Tocci, G; Battistoni, A; Rubattu, S

    2015-09-01

    The burden of cardiovascular disease (CVD) is continuously and progressively raising worldwide. Essential hypertension is a major driver of cardiovascular events, including coronary artery disease, myocardial infarction, ischemic stroke and congestive heart failure. This latter may represent the final common pathway of different cardiovascular diseases, and it is often mediated by progressive uncontrolled hypertension. Despite solid advantages derived from effective and sustained blood pressure control, and the widespread availability of effective antihypertensive medications, the vast majority of the more than 1 billion hypertensive patients worldwide continue to have uncontrolled hypertension. Among various factors that may be involved, the abnormal activation of neurohormonal systems is one consistent feature throughout the continuum of cardiovascular diseases. These systems may initiate biologically meaningful "injury responses". However, their sustained chronic overactivity often may induce and maintain the progression from hypertension towards congestive heart failure. The renin-angiotensin-aldosteron system, the sympathetic nervous system and the endothelin system are major neurohormonal stressor systems that are not only able to elevate blood pressure levels by retaining water and sodium, but also to play a role in the pathophysiology of cardiovascular diseases. More recently, the angiotensin receptor neprilysin inhibitor (ARNI) represents a favourable approach to inhibit neutral endopeptidase (NEP) and suppress the RAAS via blockade of the AT1 receptors, without the increased risk of angioedema. LCZ696, the first-in-class ARNI, has already demonstrated BP lowering efficacy in patients with hypertension, in particular with respect to systolic blood pressure levels, improved cardiac biomarkers, cardiac remodelling and prognosis in patients with heart failure. This manuscript will briefly overview the main pathophysiological and therapeutic aspects of ARNI in the clinical management of hypertension and heart failure. PMID:26100410

  9. Japan Fulbright Memorial Fund Program Opens New Avenues for Effective Technology Integration into Education

    NASA Astrophysics Data System (ADS)

    Paoletti, Franco; Carlucci, Lisa Marie

    2006-04-01

    Technology is increasingly playing a major role in today's education often integrated into instruction to become one of the teacher's most effective and often indispensable tools used in the classroom. It can be said that the use of technology at the beginning of this new millennium is affecting the instructional process and it is changing some of its basic connotations. The presented work analyzes the impact of various technologies on education emphasizing the advantages provided by a successful integration, the obstacles encountered along the way, and the methodologies currently used in the process. ``Educational exchange can turn nations into people, contributing as no other form of communication can to the humanizing of international relations'' (Senator J.M. Fulbright). Technology of this modern era is providing the indispensable tool to achieve this superior level of communication overcoming historical, cultural, and language barriers. In the context of the Japan Fulbright Memorial Fund (JFMF) Teacher Program, we analyze the impact of technology on educational cross-cultural exchanges to raise awareness and interest of the scientific/educational community on the need of establishing stronger international relations promoting world peace and global prosperity.

  10. The applicability of OSL as a sedimentological proxy: new avenues to distinguish extreme events

    NASA Astrophysics Data System (ADS)

    Lopez, G. I.

    2012-12-01

    Signature underwater tsunami deposits have been relatively recently found in the upper Mediterranean shelf offshore Israel. They have been attributed as a potential cause for the demise of the ancient Roman city of Caesarea Maritima and its artificial Herodian harbour of Sebastos. Present annual large winter storm activity (2010-2011; waves heights up to 14 m) has severely impacted the area, showing increased coastal erosion and rigorous movement of nearshore sands, complicating the stratigraphical histories of the near offshore record. Recent sedimentological and geoarchaeological studies conducted in and around the harbour have been aimed to investigate extreme event characterization by different means, using Optically Stimulated Luminescence (OSL). A comparative study of modern and palaeo-storm sediments was launched in order to obtain physical correlation between offshore sediments, enabling further comparison with historical tsunami deposits, as well as modern and ancient sands emplaced during normal marine conditions. A suite of previously collected and identified sediment samples was selected from the same area where the modern storm analogues were collected. The palaeo-samples came from long-vertical hydraulic percussion cores (14-30 m depths) and small horizontal tubes pushed into excavated underwater sediment walls (2-12 m depths). The uniqueness of OSL relays on its capacity to date the last time a mineral grain was effectively exposed to sunlight, just prior to its burial. It is intrinsically related to final depositional process, which should reflect the completeness of the OSL signal resetting (zeroing process), evidenced by the normality and modality of the Equivalent Dose (DE) distribution. In Optical Dating, DE over-dispersion values have been used as a measure of inhomogeneitiy in the natural palaeo-dose of sediments. Such heterogeneity can be due to an array of causes, including insufficient zeroing during transport and deposition, or turbation processes after burial. Environments where sediments are well exposed to daylight at deposition (e.g. aeolian and some coastal) do not show extreme over-dispersion values but rather well clustered DE's as noted by probability-distribution plots. The degrees of variance and skewness of Gaussian or relative-probability distributions are intrinsically related to the scatter factor. Hence, the latter could be used to differentiate between depositional mechanisms and/or environmental settings. In this study, the single-aliquot regenerative-dose (SAR) protocol was used to measure the OSL signals from single grains of quartz from tsunami, storm and normal marine conditions deposits. Over-dispersion analyses were conducted on all samples. Preliminary results suggest the possibility of differentiating between all three types of deposits based on pre-established over-dispersion values and representative single-dose population distributions. Further comparative OSL experiments are currently being carried out on other known tsunamigenic analogues to further evaluate OSL signal behaviours and constrain the findings (2011 Tohoku Tsunami; 1979 night Petatlán Tsunami). Rather than a dating tool, OSL was used to identify signal patterns exclusive to known depositional conditions, in hope of applying it as sedimentological proxy in event stratigraphy and palaeoseismic tsunami research.

  11. Lab-on-fiber technology: a new avenue for optical nanosensors

    NASA Astrophysics Data System (ADS)

    Consales, Marco; Pisco, Marco; Cusano, Andrea

    2012-12-01

    The "lab-on-fiber" concept envisions novel and highly functionalized technological platforms completely integrated in a single optical fiber that would allow the development of advanced devices, components and sub-systems to be incorporated in modern optical systems for communication and sensing applications. The realization of integrated optical fiber devices requires that several structures and materials at nano- and micro-scale are constructed, embedded and connected all together to provide the necessary physical connections and light-matter interactions. This paper reviews the strategies, the main achievements and related devices in the lab-on-fiber roadmap discussing perspectives and challenges that lie ahead.

  12. Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues

    PubMed Central

    Konar, Arpita; Singh, Padmanabh; Thakur, Mahendra K.

    2016-01-01

    Age-associated cognitive decline is an inevitable phenomenon that predisposes individuals for neurological and psychiatric disorders eventually affecting the quality of life. Scientists have endeavored to identify the key molecular switches that drive cognitive decline with advancing age. These newly identified molecules are then targeted as recovery of cognitive aging and related disorders. Cognitive decline during aging is multi-factorial and amongst several factors influencing this trajectory, gene expression changes are pivotal. Identifying these genes would elucidate the neurobiological underpinnings as well as offer clues that make certain individuals resilient to withstand the inevitable age-related deteriorations. Our laboratory has focused on this aspect and investigated a wide spectrum of genes involved in crucial brain functions that attribute to senescence induced cognitive deficits. We have recently identified master switches in the epigenome regulating gene expression alteration during brain aging. Interestingly, these factors when manipulated by chemical or genetic strategies successfully reverse the age-related cognitive impairments. In the present article, we review findings from our laboratory and others combined with supporting literary evidences on molecular switches of brain aging and their potential as recovery targets. PMID:27114845

  13. Dale Avenue School Early Childhood Education Center Project. Research Bulletin, Volume I, No 1, December 1970.

    ERIC Educational Resources Information Center

    Paterson Board of Education, NJ.

    Published prior to the 1970 implementation of a Paterson, New Jersey, Title III early childhood program for 120 pre-kindergarten and 120 kindergarten aged disadvantaged children, the bulletin describes the school and student population, the evaluation procedure, differences between experimental and control groups, results of pretesting, the eight…

  14. Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation.

    PubMed

    Oliveri, Valentina; Bellia, Francesco; Pietropaolo, Adriana; Vecchio, Graziella

    2015-09-28

    Mounting evidence suggests an important role of cyclodextrins in providing protection in neurodegenerative disorders. Metal dyshomeostasis is reported to be a pathogenic factor in neurodegeneration because it could be responsible for damage involving oxidative stress and protein aggregation. As such, metal ions represent an effective target. To improve the metal-binding ability of cyclodextrin, we synthesized three new 8-hydroxyquinoline-cyclodextrin conjugates with difunctionalized cyclodextrins. In particular, the 3-difunctionalized regioisomer represents the first example of cyclodextrin with two pendants at the secondary rim, resulting in a promising compound. The derivatives have significant antioxidant capacity and the powerful activity in inhibiting self-induced amyloid-β aggregation seems to be led by synergistic effects of both cyclodextrin and hydroxyquinoline. Moreover, the derivatives are also able to complex metal ions and to inhibit metal-induced protein aggregation. Therefore, these compounds could have potential as therapeutic agents in diseases related to protein aggregation and metal dyshomeostasis. PMID:26298549

  15. Hazelwood Interim Storage Site environmental report for calendar year 1992, 9200 Latty Avenue, Hazelwood, Missouri

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Hazelwood Interim storage Site (HISS) and surrounding area, provides the results for 1992, and discusses applicable environmental standards and requirements with which the results were compared. HISS is located in eastern Missouri in the City of Hazelwood (St. Louis County) and occupies approximately 2.2 ha (5.5 acres). Environmental monitoring of HISS began in 1984 when the site was assigned to the US Department of Energy (DOE) as part of the decontamination research and development project authorized by Congress under the 1984 Energy and Water Development Appropriations Act. DOE placed responsibility for HISS under the Formerly Utilized Sites Remedial Action Program (FUSRAP), which was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. In 1992 there were no environmental occurrences or unplanned contaminant releases as defined in DOE requirements and in the Superfund Amendment and Reauthorization Act (SARA) Title III of CERCLA.

  16. New avenues for regulation of lipid metabolism by thyroid hormones and analogs.

    PubMed

    Senese, Rosalba; Lasala, Pasquale; Leanza, Cristina; de Lange, Pieter

    2014-01-01

    Weight loss due to negative energy balance is a goal in counteracting obesity and type 2 diabetes mellitus. The thyroid is known to be an important regulator of energy metabolism through the action of thyroid hormones (THs). The classic, active TH, 3,5,3'-triiodo-L-thyronine (T3) acts predominantly by binding to nuclear receptors termed TH receptors (TRs), that recognize TH response elements (TREs) on the DNA, and so regulate transcription. T3 also acts through "non-genomic" pathways that do not necessarily involve TRs. Lipid-lowering therapies have been suggested to have potential benefits, however, the establishment of comprehensive therapeutic strategies is still awaited. One drawback of using T3 in counteracting obesity has been the occurrence of heart rhythm disturbances. These are mediated through one TR, termed TRα. The end of the previous century saw the exploration of TH mimetics that specifically bind to TR beta in order to prevent cardiac disturbances, and TH derivatives such as 3,5-diiodo-L-thyronine (T2), that possess interesting biological activities. Several TH derivatives and functional analogs have low affinity for the TRs, and are suggested to act predominantly through non-genomic pathways. All this has opened new perspectives in thyroid physiology and TH derivative usage as anti-obesity therapies. This review addresses the pros and cons of these compounds, in light of their effects on energy balance regulation and on lipid/cholesterol metabolism. PMID:25538628

  17. Participation in Field Learning and Teaching Opportunities: Avenues to Research and Publication

    ERIC Educational Resources Information Center

    Albert, Donald; Strait, John; Fujimoto-Strait, Ava

    2016-01-01

    Field experiences continue to be a hallmark of a geographer's education and, for that matter, reeducation, as we all strive to remain current in the real world. Academic geographers beginning their ascent towards tenure and promotion might consider augmenting their portfolios with materials emerging from field teaching and learning activities.

  18. Avenues to Professional Learning Online: Technology Tips and Tools for Professional Development in Gifted Education

    ERIC Educational Resources Information Center

    Little, Catherine A.; Housand, Brian C.

    2011-01-01

    The use of online methods for professional development activities is on the rise, with more schools exploring creative ways of providing teacher learning opportunities. Online professional development offers a promising direction for providing increased learning opportunities, promoting professional collaboration, and supporting teacher facility…

  19. Statistical challenges of quality of life and cancer: new avenues for future research.

    PubMed

    Boyer, Laurent; Baumstarck, Karine; Michel, Pierre; Boucekine, Mohamed; Anota, Amelie; Bonnetain, Franck; Coste, Joel; Falissard, Bruno; Guilleux, Alice; Hardouin, Jean-Benoit; Loundou, Anderson; Mercier, Mariette; Mesbah, Mounir; Rouquette, Alexandra; Sebille, Veronique; Verdam, Mathilde G E; Ghattas, Badih; Guillemin, Francis; Auquier, Pascal

    2014-02-01

    Statistical modeling conference on the quality of life measurements of the French National Platform of Quality of Life and Cancer Faculty of Science in Luminy, Marseille, France, 12-13 September 2013 The French National Platform of Quality of Life and Cancer and the statistical team of the Mathematical Institute of Luminy undertook a successful first conference addressing the statistical challenges of measuring the quality of life in the field of oncology. More than 15 presentations were made over a 2-day period by the Faculty of Sciences in Luminy. The conference managed to assemble participants from different disciplines, such as mathematics and statistics, public health, epidemiology and psychology, to debate the key statistical and methodological issues of quality of life measurement and analysis. Three main topics were covered in this conference: the treatment of missing data, the development of item banking and computerised adaptive testing and the detection/understanding of response shift. PMID:24378121

  20. Pendular proteins in gases and new avenues for characterization of macromolecules by ion mobility spectrometry

    PubMed Central

    Shvartsburg, Alexandre A.; Noskov, Sergei Y.; Purves, Randy W.; Smith, Richard D.

    2009-01-01

    Polar molecules align in electric fields when the dipole energy (proportional to field intensity E × dipole moment p) exceeds the thermal rotational energy. Small molecules have low p and align only at inordinately high E or upon extreme cooling. Many biomacromolecules and ions are strong permanent dipoles that align at E achievable in gases and room temperature. The collision cross-sections of aligned ions with gas molecules generally differ from orientationally averaged quantities, affecting ion mobilities measured in ion mobility spectrometry (IMS). Field asymmetric waveform IMS (FAIMS) separates ions by the difference between mobilities at high and low E and hence can resolve and identify macroion conformers based on the mobility difference between pendular and free rotor states. The exceptional sensitivity of that difference to ion geometry and charge distribution holds the potential for a powerful method for separation and characterization of macromolecular species. Theory predicts that the pendular alignment of ions in gases at any E requires a minimum p that depends on the ion mobility, gas pressure, and temperature. At ambient conditions used in current FAIMS systems, p for realistic ions must exceed ≈300–400 Debye. The dipole moments of proteins statistically increase with increasing mass, and such values are typical above ≈30 kDa. As expected for the dipole-aligned regime, FAIMS analyses of protein ions and complexes of ≈30–130 kDa show an order-of-magnitude expansion of separation space compared with smaller proteins and other ions. PMID:19351899

  1. The musical Stroop effect. Opening a new avenue to research on automatisms.

    PubMed

    Grégoire, Laurent; Perruchet, Pierre; Poulin-Charronnat, Bénédicte

    2013-01-01

    The usual color-word Stroop task, as well as most other Stroop-like paradigms, has provided invaluable information on the automaticity of word reading. However, investigating automaticity through reading alone has inherent limitations. This study explored whether a Stroop-like effect could be obtained by replacing word reading with note naming in musicians. Note naming shares with word reading the crucial advantage of being intensively practiced over years by musicians, hence allowing to investigate levels of automatism that are out of reach of laboratory settings. But the situation provides much greater flexibility in manipulating practice. For instance, even though training in musical notation is often conducted in parallel with the acquisition of literacy skills during childhood, many exceptions make that it can be easily decoupled from age. Supporting the possibility of exploiting note naming as a new tool for investigating automatisms, musicians asked to process note names written inside note pictures in incongruent positions on a staff were significantly slowed down in both a go/no-go task (Experiment 1) and a verbal task (Experiment 2) with regard to a condition in which note names were printed inside note pictures in congruent positions. PMID:23548983

  2. Arrhythmogenic right ventricular dysplasia/cardiomyopathy: new avenues for diagnosis and treatment

    PubMed Central

    van der Wall, E.E.; Bootsma, M.; Wellens, H.J.J.; Bax, J.J.; de Roos, A.; Schalij, M.J.

    2003-01-01

    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a heart muscle disorder of unknown course that is characterised pathologically by fatty or fibrofatty replacement of the right ventricular myocardium and electrical instability. Clinical manifestations include structural and functional malformations of the right ventricle, electrocardiographic abnormalities, and presentation of ventricular tachycardias with left bundle branch pattern or sudden death. The disease is often familial with an autosomal inheritance. In addition to right ventricular dilatation, right ventricular aneurysms are typical deformities of ARVD/C and they are distributed in the so-called 'triangle of dysplasia', i.e. the right ventricular outflow tract, apex and infundibulum. Ventricular aneurysms at these sites can be considered highly suggestive for ARVD/C. Another typical hallmark of ARVD/C is fatty or fibrofatty infiltration of the right ventricular free wall with potential extension to the left ventricle. These functional and morphological characteristics are relevant to clinical imaging investigations such as contrast angiography, echocardiography, radionuclide angiography, ultrafast-computed tomography and magnetic resonance (MR) imaging. Among these techniques, MR imaging allows the most comprehensive assessment of the heart, in particular because it provides functional and flow-dynamic information in addition to anatomic images. Furthermore, MR imaging offers the specific advantage of visualising adipose infiltration as a bright signal of the right ventricular myocardium. Non-pharmacological treatment by radio-frequency ablation and implantable defibrillators will play an increasing role in the treatment of patients with ARVD/C, especially in case of drug ineffectivity. Despite new diagnostic and therapeutic approaches in ARVD/C, there remain many unanswered issues since the current guidelines present criteria that are highly specific but lack sensitivity. Therefore, optimal assessment of diagnostic criteria would require a prospective evaluation from a large population obtained by an international registry. ImagesFigure 1Figure 2 PMID:25696140

  3. 78 FR 11142 - Connor Hayden Kraegel, 19917 Spurrier Avenue, Poolesville, MD 20837; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... successive Presidential Notices, the most recent being that of August 15, 2012 (77 FR 49699 (August 16, 2012... and willfully exporting from the United States a set of AN/AVS-6 night vision goggles, which...

  4. OBSERVATIONAL STUDIES VS. RANDOMIZED CONTROLLED TRIALS: AVENUES TO CAUSAL INFERENCE IN NEPHROLOGY

    PubMed Central

    Kovesdy, Csaba P; Kalantar-Zadeh, Kamyar

    2011-01-01

    A common frustration for practicing Nephrologists is the adage that the lack of randomized controlled trials (RCTs) does not allow us to establish causality, but merely associations. The field of Nephrology, like many other disciplines, has been suffering from a lack of RCTs. The view that short of RCTs there is no reliable evidence has hampered our ability to ascertain the best course of action for our patients. However, many clinically important questions in medicine and public health such as the association of smoking and lung cancer are not amenable to RCTs due to ethical or other considerations. Whereas RCTs unquestionably hold many advantages over observational studies, it should be recognized that they also have many flaws that render them fallible under certain circumstances. We provide a description of the various pros and cons of RCTs and of observational studies using examples from the Nephrology literature, and argue that it is simplistic to rank them solely based on pre-conceived notions about the superiority of one over the other. We also discuss methods whereby observational studies can become acceptable tools for causal inferences. Such approaches are especially important in a field like Nephrology where there are myriads of potential interventions based on complex pathophysiologic states, but where properly designed and conducted RCTs for all of these will probably never materialize. PMID:22364796

  5. Innovation in Parent Education: Self-Reflection and Dialogue as Avenues of Learning.

    ERIC Educational Resources Information Center

    Anderson, Lorraine Kvistberg; Thomas, Ruth G.

    A constructivist approach to parent education that enabled parents to be active participants in reflection and dialogue processes was tested in a study. Instruction was designed to stimulate and support self-reflection and dialogue processes enabling parents to be active participants in constructing new meanings to their child rearing practices.…

  6. Grassland-Cropping Rotations: An Avenue for Agricultural Diversification to Reconcile High Production with Environmental Quality.

    PubMed

    Lemaire, Gilles; Gastal, François; Franzluebbers, Alan; Chabbi, Abad

    2015-11-01

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity at all levels of organization, i.e., field, farm, landscape, and region. Therefore, we postulate that negative environmental impacts of modern agriculture are due more to production simplification than to inherent characteristics of agricultural productivity. Thus by enhancing diversity within agricultural systems, it should be possible to reconcile high quantity and quality of food production with environmental quality. Intensification of livestock and cropping systems separately within different specialized regions inevitably leads to unacceptable environmental impacts because of the overly uniform land use system in intensive cereal areas and excessive N-P loads in intensive animal areas. The capacity of grassland ecosystems to couple C and N cycles through microbial-soil-plant interactions as a way for mitigating the environmental impacts of intensive arable cropping system was analyzed in different management options: grazing, cutting, and ley duration, in order to minimize trade-offs between production and the environment. We suggest that integrated crop-livestock systems are an appropriate strategy to enhance diversity. Sod-based rotations can temporally and spatially capture the benefits of leys for minimizing environmental impacts, while still maintaining periods and areas of intensive cropping. Long-term experimental results illustrate the potential of such systems to sequester C in soil and to reduce and control N emissions to the atmosphere and hydrosphere. PMID:26070897

  7. Long Circulating Lectin Conjugated Paclitaxel Loaded Magnetic Nanoparticles: A New Theranostic Avenue for Leukemia Therapy

    PubMed Central

    Singh, Abhalaxmi; Dilnawaz, Fahima; Sahoo, Sanjeeb Kumar

    2011-01-01

    Amongst all leukemias, Bcr-Abl positive chronic myelogenous leukemia (CML) confers resistance to native drug due to multi drug resistance and also resistance to p53 and fas ligand pathways. In the present study, we have investigated the efficacy of microtubule stabilizing paclitaxel loaded magnetic nanoparticles (pac-MNPs) to ascertain its cytotoxic effect on Bcr-Abl positive K562 cells. For active targeted therapy, pac-MNPs were functionalized with lectin glycoprotein which resulted in higher cellular uptake and lower IC50 value suggesting the efficacy of targeted delivery of paclitaxel. Both pac-MNPs and lectin conjugated pac-MNPs have a prolonged circulation time in serum suggesting increased bioavailability and therapeutics index of paclitaxel in vivo. Further, the molecular mechanism pertaining to pac-induced cytotoxicity was analyzed by studying the involvement of different apoptotic pathway proteins by immunoblotting and quantitative PCR. Our study revealed simultaneous activation of JNK pathway leading to Bcr-Abl instability and the extrinsic apoptotic pathway after pac-MNPs treatment in two Bcr-Abl positive cell lines. In addition, the MRI data suggested the potential application of MNPs as imaging agent. Thus our in vitro and in vivo results strongly suggested the pac-MNPs as a future prospective theranostic tool for leukemia therapy. PMID:22110595

  8. The Creative Arts: An Avenue to Wellness among Native American Indians.

    ERIC Educational Resources Information Center

    Herring, Roger D.

    1997-01-01

    Describes how creative arts are enmeshed in historical and contemporary Native spiritual and humanistic value systems. Claims that the interconnectedness of creative arts and Native existence represents a feasible option for helping professionals who work with this population. Presents examples to support the potential of this intervention. (RJM)

  9. Tethers in space: Birth and growth of a new avenue to space utilization

    NASA Technical Reports Server (NTRS)

    Vontiesenhausen, G.

    1984-01-01

    The evolution of the ideas of tether applications in space are traced from its origin in the last century past a dormant period of sixty-five years to the mid-seventies. At that time as a consequence of major revival efforts, NASA entered into serious investigations of the theoretical and practical feasibility of a large number of tethered concepts in space. These efforts culminated in the establishment of the Tethered Satellite System Project now at NASA in the advanced development phase. Extensive planning efforts are described, first, through a Tether Applications in Space Workshop which generated additional concepts and provided overall assessments and recommendations to NASA, and then through a NASA inter-center Tether Applications in Space Task Group which generated a four year program plan in the areas of further studies, technology, work and science and applications of tethers in space. An outlook into the future of tether applications that approaches some of the goals of the early visionaries is offered.

  10. Oxytocin enables novelty seeking and creative performance through upregulated approach: evidence and avenues for future research.

    PubMed

    De Dreu, Carsten K W; Baas, Matthijs; Boot, Nathalie C

    2015-01-01

    Oxytocin is an evolutionary ancient hypothalamic neuropeptide well known for its role in reproduction, social bonding, and group affiliation. Recent work has linked oxytocin in humans to creative cognition--the ability to produce insights, ideas, and problem solutions that are original and potentially useful. Here we review this literature, focusing on the relationship between (1) single-nucleotide polymorphisms in the oxytocin receptor (OXTR) gene; endogenous oxytocin from blood plasma, and intranasal administration of oxytocin (vs placebo), and (2) creativity-related traits (e.g., novelty seeking, extraversion, and openness to experience), and behaviors (e.g., exploration, divergent thinking, original ideation, and problem solving). Findings are interpreted in the context of the dual pathway to creativity model and except for OXTR: (1) reveal a weak to moderate but consistent association between oxytocin and creativity, which emerges because (2) oxytocin enables the cognitive flexibility pathway more than persistent information processing. Findings can be best understood in terms of oxytocin's putative effects on dopaminergic activity and concomitant approach tendency. PMID:26267407

  11. Exploring Symmetry as an Avenue to the Computational Design of Large Protein Domains

    SciTech Connect

    Fortenberry, Carie; Bowman, Elizabeth Anne; Proffitt, Will; Dorr, Brent; Combs, Steven; Harp, Joel; Mizoue, Laura; Meiler, Jens

    2012-03-15

    It has been demonstrated previously that symmetric, homodimeric proteins are energetically favored, which explains their abundance in nature. It has been proposed that such symmetric homodimers underwent gene duplication and fusion to evolve into protein topologies that have a symmetric arrangement of secondary structure elements - 'symmetric superfolds'. Here, the ROSETTA protein design software was used to computationally engineer a perfectly symmetric variant of imidazole glycerol phosphate synthase and its corresponding symmetric homodimer. The new protein, termed FLR, adopts the symmetric ({beta}{alpha}){sub 8} TIM-barrel superfold. The protein is soluble and monomeric and exhibits two-fold symmetry not only in the arrangement of secondary structure elements but also in sequence and at atomic detail, as verified by crystallography. When cut in half, FLR dimerizes readily to form the symmetric homodimer. The successful computational design of FLR demonstrates progress in our understanding of the underlying principles of protein stability and presents an attractive strategy for the in silico construction of larger protein domains from smaller pieces.

  12. Probabilistic inversion in the context of EM studies: Where we are and avenues for the future

    NASA Astrophysics Data System (ADS)

    Linde, Niklas; Rosas-Carbajal, Marina

    2016-04-01

    Modern Markov chain Monte Carlo (MCMC) algorithms can explore the posterior distribution of highly non-linear inverse problems in moderately high dimensions. For instance, 2-D magnetotelluric inversion is feasible for several hundreds of independent model parameters. At present, 3-D applications are limited to a few tenths of model parameters, but even such low dimensions make MCMC useful in time-lapse inversions when using appropriate model parameterizations. It is straightforward to invert for the noise level of the data (i.e., hierarchical Bayes) and the appropriate strength of the prior constraints (i.e., empirical Bayes). It is even possible to consider the dimension of the problem as an unknown (i.e., reversible-jump or transdimensional inversion). Nevertheless, persistent problems that plague MCMC inversions in geophysics include the choice of the prior probability density function, overly simplistic descriptions of data and modeling errors in the likelihood function, as well as truncation errors or spectral leakage that are inevitable when describing the Earth by a finite number of parameters. This leads to uncertainty estimates that often are overly optimistic (or alternatively limited by a too restrictive set of hypotheses) and final results that at times are only vaguely more informative than those obtained by classical Occam inversions. We argue that formal model selection, multiple-point statistics and approximate Bayesian computation may offer solutions to overcome some of these outstanding issues.

  13. Molecular epidemiology in cancer risk assessment and prevention: recent progress and avenues for future research.

    PubMed Central

    Wogan, G N

    1992-01-01

    Molecular epidemiology is increasingly being applied in studies of cancer risks derived from exposure to environmental carcinogens of both endogenous and exogenous origins. Analytical methods have been developed that are capable of detecting and quantifying levels of covalent adducts of several important classes of carcinogens with cellular DNA and blood proteins. Methods of sufficient sensitivity and specificity to detect ambient levels of exposure are in current use. These are being used in studies related to tobacco use (polycyclic aromatic hydrocarbons, aromatic amines, tobacco-specific nitrosamines); dietary exposures (aflatoxins, N-nitrosamines, heterocyclic amines); medicinal exposures (cisplatin, alkylating agents, 8-methoxypsoralen, ultraviolet photoproducts); occupational exposures (aromatic amines, polycyclic aromatic hydrocarbons, oxides of ethylene and styrene, and vinyl chloride); and oxidative damage (8-hydroxyguanine, thymine glycol). Methodologic improvements together with their expanded use in feasibility studies continue to produce results that support the validity of this approach for detecting and quantifying exposure to carcinogens. Genetic markers are also being used to detect early biological responses in efforts to link carcinogen exposure to initiating events in the carcinogenesis process. These include, in addition to traditional cytogenetic markers (e.g., chromosomal aberrations, sister chromatid exchange, micronuclei), other alterations in chromosomal structure such as restriction fragment length polymorphisms, loss of heterozygosity, and translocation markers. Specific genetic changes have recently been identified as critical molecular events in the initiation and development of many cancers. Important among these are activation of oncogenes, especially those of the ras family, and inactivation of tumor-suppressor genes (e.g., p53 and Rb) by point mutations and/or chromosomal deletions and other structural changes. Although some of these changes are known to occur in chemically induced tumors of experimental animals, the possible role of chemical carcinogens in the induction of genetic abnormalities in human cancers has yet to be determined. Continuing investigations employing the methods of molecular epidemiology promise to provide further evidence concerning these relationships. Future investigations employing newly developed molecular biological methods, in particular those based on polymerase chain reaction amplification of DNA, to identify alterations in DNA and chromosomal structure, combined with methods for characterizing exposure to carcinogens and early effects, have great potential for further elucidating the role of genotoxic agents in the etiology of human cancers and also for the development of strategies for their prevention. PMID:1486846

  14. Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals

    PubMed Central

    Sargis, Robert M

    2015-01-01

    The global epidemic of metabolic disease is a clear and present danger to both individual and societal health. Understanding the myriad factors contributing to obesity and diabetes is essential for curbing their decades-long expansion. Emerging data implicate environmental endocrine disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes. The phenylsulfamide fungicide and anti-fouling agent tolylfluanid (TF) was recently added to the list of EDCs promoting metabolic dysfunction. Dietary exposure to this novel metabolic disruptor promoted weight gain, increased adiposity, and glucose intolerance as well as systemic and cellular insulin resistance. Interestingly, the increase in body weight and adipose mass was not a consequence of increased food consumption; rather, it may have resulted from disruptions in diurnal patterns of energy intake, raising the possibility that EDCs may promote metabolic dysfunction through alterations in circadian rhythms. While these studies provide further evidence that EDCs may promote the development of obesity and diabetes, many questions remain regarding the clinical factors that modulate patient-specific consequences of EDC exposure, including the impact of genetics, diet, lifestyle, underlying disease, pharmacological treatments, and clinical states of fat redistribution. Currently, little is known regarding the impact of these factors on an individual’s susceptibility to environmentally-mediated metabolic disruption. Advances in these areas will be critical for translating EDC science into the clinic to enable physicians to stratify an individual’s risk of developing EDC-induced metabolic disease and to provide direction for treating exposed patients. PMID:27011951

  15. The Madison Avenue Effect: How drug presentation style influences adherence and outcome in patients with asthma

    PubMed Central

    Clerisme-Beaty, Emmanuelle M; Bartlett, Susan J; Teague, W. Gerald; Lima, John; Irvin, Charles G; Cohen, Rubin; Castro, Mario; Wise, Robert A; Rand, Cynthia S

    2010-01-01

    Background Little is known about how drug presentation influences medication adherence. Objective Examine the effect of an educational program aimed at increasing expectations of treatment benefit on medication adherence. Methods Data are analyzed from 99 participants who underwent electronic drug monitoring during TAPE (Trial of Asthma Patient Education), a randomized placebo-controlled multi-center trial. Participants with suboptimally-controlled asthma were randomized to placebo or montelukast in conjunction with a presentation mode that was either neutral or designed to increase outcome expectancy. Adherence was monitored electronically over 4 weeks, and was defined as ≥ 80% use of prescribed doses. Outcome expectancy, peak expiratory flow, pre-bronchodilator forced expiratory volume, asthma control (ACQ), and asthma-related quality of life were assessed at baseline and at the 4-week follow-up. Results Average electronic medication adherence was 69.9%. There was a significant interaction between presentation mode and drug assignment, with participants in the enhanced/montelukast group having a higher change in outcome expectancy (Δ 2.1 points, p < 0.001) and better medication adherence (odds ratio 4.0, CI 1.1, 14.3) compared to those in the neutral/placebo group. There was no difference in asthma symptoms, quality of life, or clinical outcomes based on presentation mode. Rather, increased outcome expectancy was associated with modest improvements in asthma symptoms after adjusting for presentation mode, drug assignment, and medication adherence. Conclusion The use of an enhanced presentation aimed at increasing outcome expectancy may lead to improved medication adherence. PMID:21281871

  16. Grassland-Cropping Rotations: An Avenue for Agricultural Diversification to Reconcile High Production with Environmental Quality

    NASA Astrophysics Data System (ADS)

    Lemaire, Gilles; Gastal, François; Franzluebbers, Alan; Chabbi, Abad

    2015-11-01

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity at all levels of organization, i.e., field, farm, landscape, and region. Therefore, we postulate that negative environmental impacts of modern agriculture are due more to production simplification than to inherent characteristics of agricultural productivity. Thus by enhancing diversity within agricultural systems, it should be possible to reconcile high quantity and quality of food production with environmental quality. Intensification of livestock and cropping systems separately within different specialized regions inevitably leads to unacceptable environmental impacts because of the overly uniform land use system in intensive cereal areas and excessive N-P loads in intensive animal areas. The capacity of grassland ecosystems to couple C and N cycles through microbial-soil-plant interactions as a way for mitigating the environmental impacts of intensive arable cropping system was analyzed in different management options: grazing, cutting, and ley duration, in order to minimize trade-offs between production and the environment. We suggest that integrated crop-livestock systems are an appropriate strategy to enhance diversity. Sod-based rotations can temporally and spatially capture the benefits of leys for minimizing environmental impacts, while still maintaining periods and areas of intensive cropping. Long-term experimental results illustrate the potential of such systems to sequester C in soil and to reduce and control N emissions to the atmosphere and hydrosphere.

  17. Aggression, Violence and Injury in Minor League Ice Hockey: Avenues for Prevention of Injury

    PubMed Central

    Cusimano, Michael D.; Ilie, Gabriela; Mullen, Sarah J.; Pauley, Christopher R.; Stulberg, Jennifer R.; Topolovec-Vranic, Jane; Zhang, Stanley

    2016-01-01

    Background In North America, more than 800,000 youth are registered in organized ice hockey leagues. Despite the many benefits of involvement, young players are at significant risk for injury. Body-checking and aggressive play are associated with high frequency of game-related injury including concussion. We conducted a qualitative study to understand why youth ice hockey players engage in aggressive, injury-prone behaviours on the ice. Methods Semi-structured interviews were conducted with 61 minor ice hockey participants, including male and female players, parents, coaches, trainers, managers and a game official. Players were aged 13–15 playing on competitive body checking teams or on non-body checking teams. Interviews were manually transcribed, coded and analyzed for themes relating to aggressive play in minor ice hockey. Results Parents, coaches, teammates and the media exert a large influence on player behavior. Aggressive behavior is often reinforced by the player’s social environment and justified by players to demonstrate loyalty to teammates and especially injured teammates by seeking revenge particularly in competitive, body-checking leagues. Among female and male players in non-body checking organizations, aggressive play is not reinforced by the social environment. These findings are discussed within the framework of social identity theory and social learning theory, in order to understand players’ need to seek revenge and how the social environment reinforces aggressive behaviors. Conclusion This study provides a better understanding of the players’ motivations and environmental influences around aggressive and violent play which may be conducive to injury. The findings can be used to help design interventions aimed at reducing aggression and related injuries sustained during ice hockey and sports with similar cultures and rules. PMID:27258426

  18. Religious and Spiritual Beliefs: An Avenue to Explore End-of-Life Issues

    ERIC Educational Resources Information Center

    Reiner, Summer M.

    2007-01-01

    This literature review highlights the relationship between spirituality and/or religion and how people respond in the face of impending death. Attitudes toward physician-assisted suicide and hospice are explored. The author also offers recommendations to counselors for addressing religious and spiritual concerns.

  19. Monitoring Fatigue Status with HRV Measures in Elite Athletes: An Avenue Beyond RMSSD?

    PubMed

    Schmitt, Laurent; Regnard, Jacques; Millet, Grégoire P

    2015-01-01

    Among the tools proposed to assess the athlete's "fatigue," the analysis of heart rate variability (HRV) provides an indirect evaluation of the settings of autonomic control of heart activity. HRV analysis is performed through assessment of time-domain indices, the square root of the mean of the sum of the squares of differences between adjacent normal R-R intervals (RMSSD) measured during short (5 min) recordings in supine position upon awakening in the morning and particularly the logarithm of RMSSD (LnRMSSD) has been proposed as the most useful resting HRV indicator. However, if RMSSD can help the practitioner to identify a global "fatigue" level, it does not allow discriminating different types of fatigue. Recent results using spectral HRV analysis highlighted firstly that HRV profiles assessed in supine and standing positions are independent and complementary; and secondly that using these postural profiles allows the clustering of distinct sub-categories of "fatigue." Since, cardiovascular control settings are different in standing and lying posture, using the HRV figures of both postures to cluster fatigue state embeds information on the dynamics of control responses. Such, HRV spectral analysis appears more sensitive and enlightening than time-domain HRV indices. The wealthier information provided by this spectral analysis should improve the monitoring of the adaptive training-recovery process in athletes. PMID:26635629

  20. Monitoring Fatigue Status with HRV Measures in Elite Athletes: An Avenue Beyond RMSSD?

    PubMed Central

    Schmitt, Laurent; Regnard, Jacques; Millet, Grégoire P.

    2015-01-01

    Among the tools proposed to assess the athlete's “fatigue,” the analysis of heart rate variability (HRV) provides an indirect evaluation of the settings of autonomic control of heart activity. HRV analysis is performed through assessment of time-domain indices, the square root of the mean of the sum of the squares of differences between adjacent normal R-R intervals (RMSSD) measured during short (5 min) recordings in supine position upon awakening in the morning and particularly the logarithm of RMSSD (LnRMSSD) has been proposed as the most useful resting HRV indicator. However, if RMSSD can help the practitioner to identify a global “fatigue” level, it does not allow discriminating different types of fatigue. Recent results using spectral HRV analysis highlighted firstly that HRV profiles assessed in supine and standing positions are independent and complementary; and secondly that using these postural profiles allows the clustering of distinct sub-categories of “fatigue.” Since, cardiovascular control settings are different in standing and lying posture, using the HRV figures of both postures to cluster fatigue state embeds information on the dynamics of control responses. Such, HRV spectral analysis appears more sensitive and enlightening than time-domain HRV indices. The wealthier information provided by this spectral analysis should improve the monitoring of the adaptive training-recovery process in athletes. PMID:26635629

  1. Beyond DOtS: avenues ahead in the management of tuberculosis.

    PubMed

    Chaudhury, Ranjit Roy; Thatte, Urmila

    2003-01-01

    India has almost 30% of the global burden of tuberculosis (TB)--one person dies of the disease every minute in our country. India has mounted the second-largest DOTS programme in the world to control this disease. However, DOTS has its limitations and newer approaches have been developed over the years to overcome the global burden of tuberculosis. Problems with health facilities, patients, drugs and the disease itself constitute some of the hurdles in the implementation of the DOTS programme. In an attempt to go beyond DOTS, the WHO launched the 'Stop TB Initiative' in 1988. Against the background of irrational antituberculosis drug use, which contributes to increasing drug resistance, the effective involvement of private healthcare providers is imperative to achieve better geographical and patient coverage for the implementation of DOTS. The WHO is currently addressing the issue of involving private practitioners in tuberculosis control in a programme called Public-Private Mix DOTS (PPM DOTS). The Stop TB Initiative is also active in the area of dual infection with HIV and tuberculosis, and the initiatives that have been taken in this area include 'ProTEST', community contribution to tuberculosis care, and development and dissemination of training materials and guidelines. The DOTS-Plus strategy for the management of multidrug resistant (MDR)-TB and the establishment of the Green Light Committee to review project applications in this area are initiatives taken to curb the problem of drug resistance in tuberculosis. Even decades after the introduction of the DOTS strategy, much needs to be done to expand the services to the entire population; it is now essential to develop strategies that go beyond DOTS. PMID:14765625

  2. G protein-coupled receptors as oncogenic signals in glioma: emerging therapeutic avenues

    PubMed Central

    Cherry, Allison E; Stella, Nephi

    2014-01-01

    Gliomas are the most common malignant intracranial tumors. Newly developed targeted therapies for these cancers aim to inhibit oncogenic signals, many of which emanate from receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR). Unfortunately, the first generation treatments targeting these oncogenic signals provide little survival benefit in both mouse xenograft models and human patients. The search for new treatment options has uncovered several G protein-coupled receptor (GPCR) candidates and generated a growing interest in this class of proteins as alternative therapeutic targets for the treatment of various cancers, including GBM. GPCRs constitute a large family of membrane receptors that influence oncogenic pathways through canonical and non-canonical signaling. Accordingly, evidence indicates that GPCRs display a unique ability to crosstalk with receptor tyrosine kinases, making them important molecular components controlling tumorigenesis. This review summarizes the current research on GPCR functionality in gliomas and explores the potential of modulating these receptors to treat this devastating disease. PMID:25158675

  3. Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

    PubMed

    Timmers, Silvie; Hesselink, Matthijs K C; Schrauwen, Patrick

    2013-07-01

    The number of people suffering from metabolic disorders is dramatically increasing worldwide. The need for new therapeutic strategies to combat this growing epidemic of metabolic diseases is therefore also increasing. In 2003, resveratrol was discovered to be a small molecule activator of sirtuin 1 (SIRT1), an important molecular target regulating cellular energy metabolism and mitochondrial homeostasis. Rodent studies have clearly demonstrated the potential of resveratrol to improve various metabolic health parameters. To date, however, only limited clinical data are available that have systematically examined the health benefits of resveratrol in metabolically challenged humans. This short review will give an overview of the currently available clinical studies examining the effects of resveratrol on obesity and type 2 diabetes from a human perspective. PMID:23855469

  4. An inexorable trend of and major avenues to the diversion of China's agricultural labour force.

    PubMed

    Xu, T; Ye, Z

    1986-07-01

    The diversion of agricultural labor force to other sectors of the work force is a necessary course every country has to experience in a certain historical stage as a result of development. The diversion of farm labor indicates a new level of social productivity; mankind can get more products by less labor and the new domain of human activities is continuously exploited. With the improvement of China's agricultural modernization and the increase in farm laborers over the past 30 years, surplus farm labor has reached 30% or .15 billion. The projected rural labor force will reach .45 billion by 2000, but all the arable land of China's rural areas can only accommodate .135 billion by the turn of the century; therefore, more than 300 million agricultural laborers must be diverted to other sectors. Some actions that may divert agricultural workers include: 1) developing the rural family economy in the areas of industry, commerce, communication, transportation, building, and services; 2) rapidly developing town enterprises to offer jobs in the food, forage, building, transportation and service industries; 3) actively developing and building small cities and towns to divert the agricultural population to a nonagricultural population. This will improve the productivity arrangement, adjust the distribution of rural-urban population, organize the exchange of materials, qualified personnel and information, and upgrade the science and education level of the whole nation; 4) encouraging farmers to settle their own grain ration and raise funds while going to towns and border areas to trade goods. PMID:12268826

  5. Non-Verbal Communication Training: An Avenue for University Professionalizing Programs?

    ERIC Educational Resources Information Center

    Gazaille, Mariane

    2011-01-01

    In accordance with today's workplace expectations, many university programs identify the ability to communicate as a crucial asset for future professionals. Yet, if the teaching of verbal communication is clearly identifiable in most university programs, the same cannot be said of non-verbal communication (NVC). Knowing the importance of the…

  6. Avenues and incentives for commercial use of a low-g environment

    NASA Technical Reports Server (NTRS)

    Brown, R. L.; Zoller, L. K.

    1981-01-01

    The processing of materials in a low-gravity (low-g) or microgravity environment is investigated by NASA for scientific and commercial utilization, and process and product development. The elimination of gravity is shown to create unique materials, and improve ground-based processes, such as convection, sedimentation, buoyancy, and containerless processing. Commercial applications are discussed, including the manufacturing of silicon ribbon, turbine blades, and various pharmaceuticals in space. Commercial incentives and needs are also discussed, including the technical exchange agreement, in which NASA and a company agree to cooperate in the conduct and analysis of research programs. In addition to establishing and demonstrating scientific and technological precepts for analyzing and using low-g environments, NASA is establishing legal and management mechanisms to share cost and risk of early commercial ventures.

  7. Can the American High School become an Avenue of Advancement for All?

    ERIC Educational Resources Information Center

    Balfanz, Robert

    2009-01-01

    As the twenty-first century opens, says Robert Balfanz, the United States is developing a deep social consensus that American high schools should ensure that all adolescents graduate from high school prepared for postsecondary schooling and training. Balfanz asks how well high schools are succeeding in this mission and whether they can ultimately…

  8. Grassland-cropping rotations: An avenue for agricultural diversification to reconcile high production with environmental quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity...

  9. Keep the fire burning: Current avenues in the quest of treating mitochondrial disorders.

    PubMed

    Tischner, Christin; Wenz, Tina

    2015-09-01

    Mitochondrial diseases are very heterogeneous in their genetic cause and clinical manifestation. During the last few decades progress has been made in the diagnosis of mitochondrial diseases, but an established therapy is so far lacking. Several experimental strategies targeting different points of intervention are currently being assessed world-wide. Numerous mouse models of OXPHOS disorders have become available enabling further optimization and validation of therapeutic strategies and paving the way for future clinical trials. In this review, we provide an update on current developments towards treatment as well as the potential and status of transition into therapeutic use. PMID:26134435

  10. Ike and the GOP in 1956: Madison Avenue Comes to the Aid of the Party.

    ERIC Educational Resources Information Center

    Allen, Craig M.

    This paper argues that Dwight Eisenhower's use of television in the political campaign in 1956 helped mark the rise of the centralized presidential campaign strategy. To determine the impact of television on this campaign and describe the campaign's inner workings, the paper recounts (1) the Republican dilemma over the use of television and the…

  11. The unexplored avenues of human skin: electromagnetic properties in the sub-THz band

    NASA Astrophysics Data System (ADS)

    Feldman, Y.; Safrai, E.; Ben Ishai, P.; Puzenko, A.; Agranat, A. J.; Caduff, A.

    2012-03-01

    Recent studies of the minute morphology of the skin by optical coherence tomography showed that the sweat ducts in human skin become helically shaped tubes in the Epidermis and are filled with an aqueous solution. When considered as entities embedded in a dielectric media, they resemble helical antennas. The spectral response obtained by our computer simulations coincides with the analytical prediction of antenna theory and support this hypothesis, if a fast enough current mechanism exists in the duct. In particular the strongest spectral response of the simulation was noted around the predicted frequencies (240 GHz and 380 GHz) for the respective normal and axial modes of the helical structure. Furthermore, circular dichroism of the reflected electromagnetic field is a characteristic property of such helical antennas and it was shown that it is indeed a characteristic of the simulation model. Fast proton hopping is posited as the current mechanism. Consequently experimental evidence is presented that the spectral response of the skin in the sub-Terahertz region is governed by the level of activity of the perspiration system. This in turn is moderated by the Sympathetic Nerve Response and is demonstrated by the correlation to physiological stress as manifested by the pulse rate and the systolic blood pressure. These physical relaxations are tonic in nature (lasting more than a minute). Could the phasic characteristic of emotional excitation also be evident in the reflection coefficient? By applying techniques borrowed from psychiatric science we hope to answer this point in our paper.

  12. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues

    PubMed Central

    Obulesu, M; Rao, Dowlathabad Muralidhara

    2011-01-01

    Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms. These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtisufolia (Sicklepod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), and Salvia officinalis (Garden sage, common sage). PMID:21716802

  13. Image of Women in Advertisements: A Preliminary Study of Avenues for Change.

    ERIC Educational Resources Information Center

    Butler-Paisley, Matilda, Ed.; And Others

    The Center for Research on Women (CROW) at Stanford University along with the Communication Department, the Psychology Department, and the School of Education conducted a study on the image of women in advertising and suggested ways to improve women's image in the advertising media. With the objective of sponsoring some alternatives to expedite…

  14. Brief Communication: Future avenues for permafrost science from the perspective of early career researchers

    NASA Astrophysics Data System (ADS)

    Fritz, M.; Deshpande, B. N.; Bouchard, F.; Högström, E.; Malenfant-Lepage, J.; Morgenstern, A.; Nieuwendam, A.; Oliva, M.; Paquette, M.; Rudy, A. C. A.; Siewert, M. B.; Sjöberg, Y.; Weege, S.

    2015-08-01

    Accelerating climate change and increased economic and environmental interests in permafrost-affected regions have resulted in an acute need for more directed permafrost research. In June 2014, 88 early career researchers convened to identify future priorities for permafrost research. This multidisciplinary forum concluded that five research topics deserve greatest attention: permafrost landscape dynamics, permafrost thermal modeling, integration of traditional knowledge, spatial distribution of ground ice, and engineering issues. These topics underline the need for integrated research across a spectrum of permafrost-related domains and constitute a contribution to the Third International Conference on Arctic Research Planning (ICARP III).

  15. Brief Communication: Future avenues for permafrost science from the perspective of early career researchers

    NASA Astrophysics Data System (ADS)

    Fritz, M.; Deshpande, B. N.; Bouchard, F.; Högtröm, E.; Lepage, J.; Morgenstern, A.; Nieuwendam, A.; Oliva, M.; Paquette, M.; Rudy, A. C. A.; Siewert, M. B.; Sjöberg, Y.; Weege, S.

    2015-02-01

    Accelerating climate change and increased economic and environmental interest in permafrost-affected regions have resulted in an acute need for more directed permafrost research. In June 2014, 88 early career researchers convened to identify future priorities for permafrost research. This multidisciplinary forum concluded that five research topics deserve greatest attention: permafrost landscape dynamics; permafrost thermal modelling; integration of traditional knowledge; spatial analysis of permafrost types and vulnerability; and engineering issues. These topics underline the need for integrated research across a spectrum of permafrost-related domains and constitute a contribution to the Third International Conference on Arctic Research Planning (ICARP III).

  16. Can the american high school become an avenue of advancement for all?

    PubMed

    Balfanz, Robert

    2009-01-01

    As the twenty-first century opens, says Robert Balfanz, the United States is developing a deep social consensus that American high schools should ensure that all adolescents graduate from high school prepared for postsecondary schooling and training. Balfanz asks how well high schools are succeeding in this mission and whether they can ultimately fulfill it. Balfanz first surveys the structure and demographics of today's high schools. Forty percent of white students attend high schools that are 90 percent or more white, while roughly one-third of Latino and African American students attend high schools that are 90 percent or more minority. Minority students are also much more likely than white students to attend high schools that confront the challenges of concentrated poverty. In predominantly white, affluent suburban school districts, nearly every student arrives ready for high school work and then graduates. In all-minority inner city schools in high-poverty neighborhoods, most entering students lack a good middle school education and only half to two-thirds graduate. With only a third to a half of high school graduates today prepared to succeed in college, how likely is it that American high schools will succeed in their mission of preparing all students for additional schooling or training? Balfanz argues that reforms over the past twenty-five years offer some hope. The standards and accountability movement has made the American high school a more focused and academic place. College preparatory course-taking has increased substantially, as has standardized testing. Mandatory exit exams have been imposed. And during the past decade, in particular, reformers have made a concerted effort to improve the low-performing high schools that serve low-income and minority students. Investments by the federal government and by foundations have led to the development of several types of reforms that have been proven effective, thus raising hopes that the nation's lowest-performing high schools can better serve their students. Still, the American high school has a considerable way to go to be able to prepare all students for further schooling or training. To advance all its students, it must find a way to bring to scale the methods and mechanisms, conditions, and know-how that have enabled a few low-performing high schools to achieve this transformation. PMID:21141703

  17. Unlocking the Genetic Diversity of Maize Landraces with Doubled Haploids Opens New Avenues for Breeding

    PubMed Central

    Strigens, Alexander; Schipprack, Wolfgang; Reif, Jochen C.; Melchinger, Albrecht E.

    2013-01-01

    Landraces are valuable genetic resources for broadening the genetic base of elite germplasm in maize. Extensive exploitation of landraces has been hampered by their genetic heterogeneity and heavy genetic load. These limitations may be overcome by the in-vivo doubled haploid (DH) technique. A set of 132 DH lines derived from three European landraces and 106 elite flint (EF) lines were genotyped for 56,110 single nucleotide polymorphism (SNP) markers and evaluated in field trials at five locations in Germany in 2010 for several agronomic traits. In addition, the landraces were compared with synthetic populations produced by intermating DH lines derived from the respective landrace. Our objectives were to (1) evaluate the phenotypic and molecular diversity captured within DH lines derived from European landraces, (2) assess the breeding potential (usefulness) of DH lines derived from landraces to broaden the genetic base of the EF germplasm, and (3) compare the performance of each landrace with the synthetic population produced from the respective DH lines. Large genotypic variances among DH lines derived from landraces allowed the identification of DH lines with grain yields comparable to those of EF lines. Selected DH lines may thus be introgressed into elite germplasm without impairing its yield level. Large genetic distances of the DH lines to the EF lines demonstrated the potential of DH lines derived from landraces to broaden the genetic base of the EF germplasm. The comparison of landraces with their respective synthetic population showed no yield improvement and no reduction of phenotypic diversity. Owing to the low population structure and rapid decrease of linkage disequilibrium within populations of DH lines derived from landraces, these would be an ideal tool for association mapping. Altogether, the DH technology opens new opportunities for characterizing and utilizing the genetic diversity present in gene bank accessions of maize. PMID:23451190

  18. Rapid synthesis of barium titanate microcubes using composite-hydroxides-mediated avenue

    SciTech Connect

    He, Xi; Ouyang, Jing Jin, Jiao; Yang, Huaming

    2014-04-01

    Highlights: • Barium titanate oxides microcubes can be synthesized within 1 min. • Composite-hydroxides-mediated strategy provided a possible large scale production. • BST obtained in the strategy showed fairly good crystallinity and tetragonality. - Abstract: This paper reports the rapid synthesis of barium titanate (BaTiO{sub 3}, BTO) microcubes via composite-hydroxides-mediated reaction within 1 min. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersion spectrum (EDS) results confirmed both cubic and tetragonal lattices in the sample and the uniform microcubes with an average size of 1 μm. Ultraviolet–visible (UV–vis) spectrum indicated that the band gap of the BTO powder was 3.05 eV. Ferroelectric polarization vs. electric field (P–E) tests showed that the ferroelectric domains had formed in the as-synthesized BTO microcubes and sintered ceramics. BTO ceramics sintered at 1100 °C for 3 h showed fairly good tetragonality and possessed a maximum polarization of 0.21 μC/cm{sup 2}, indicating that the sintering temperature for the BTO powders prepared via this method was relatively low. The process and equipment reported herein provided a potential method for the rapid synthesis of titanate based perovskites.

  19. Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier

    PubMed Central

    Villa, Carlos H; Pan, Daniel C; Zaitsev, Sergei; Cines, Douglas B; Siegel, Donald L; Muzykantov, Vladimir R

    2015-01-01

    For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics, biodistribution, controlled release and pharmacodynamics. Approaches include encapsulation of drugs within erythrocytes, as well as coupling of drugs onto the red cell surface. This review focuses on the latter approach, and examines the delivery of red blood cell (RBC)-surface-bound anti-inflammatory, anti-thrombotic and anti-microbial agents, as well as RBC carriage of nanoparticles. Herein, we discuss the progress that has been made in surface loading approaches, and address in depth the issues relevant to surface loading of RBC, including intrinsic features of erythrocyte membranes, immune considerations, potential surface targets and techniques for the production of affinity ligands. PMID:26228773

  20. Developing Instruction in Oral History: A New Avenue for Speech Communication.

    ERIC Educational Resources Information Center

    Clark, E. Culpepper; And Others

    1981-01-01

    Describes a program of advanced instruction which attempts to merge the theory of speech communication and the practice of oral history. Is concerned with how meaning is constructed through conversation between interviewer and interviewee. Includes theoretical and methodological problems inherent in producing oral histories, field research, and…

  1. New avenues for regulation of lipid metabolism by thyroid hormones and analogs

    PubMed Central

    Senese, Rosalba; Lasala, Pasquale; Leanza, Cristina; de Lange, Pieter

    2014-01-01

    Weight loss due to negative energy balance is a goal in counteracting obesity and type 2 diabetes mellitus. The thyroid is known to be an important regulator of energy metabolism through the action of thyroid hormones (THs). The classic, active TH, 3,5,3′-triiodo-L-thyronine (T3) acts predominantly by binding to nuclear receptors termed TH receptors (TRs), that recognize TH response elements (TREs) on the DNA, and so regulate transcription. T3 also acts through “non-genomic” pathways that do not necessarily involve TRs. Lipid-lowering therapies have been suggested to have potential benefits, however, the establishment of comprehensive therapeutic strategies is still awaited. One drawback of using T3 in counteracting obesity has been the occurrence of heart rhythm disturbances. These are mediated through one TR, termed TRα. The end of the previous century saw the exploration of TH mimetics that specifically bind to TR beta in order to prevent cardiac disturbances, and TH derivatives such as 3,5-diiodo-L-thyronine (T2), that possess interesting biological activities. Several TH derivatives and functional analogs have low affinity for the TRs, and are suggested to act predominantly through non-genomic pathways. All this has opened new perspectives in thyroid physiology and TH derivative usage as anti-obesity therapies. This review addresses the pros and cons of these compounds, in light of their effects on energy balance regulation and on lipid/cholesterol metabolism. PMID:25538628

  2. Basic Advances and New Avenues in Therapy of Spinal Cord Injury

    PubMed Central

    Dobkin, Bruce H.; Havton, Leif A.

    2014-01-01

    The prospects for successful clinical trials of neuroprotective and neurorestorative interventions for patients with acute and chronic myelopathies depend on preclinical animal models of injury and repair that reflect the human condition. Remarkable progress continues in the attempt to promote connections between the brain and the sensory and motor neurons below a spinal cord lesion. Recent experiments demonstrate the potential for biological therapies to regenerate or remyelinate axons and to incorporate new neural cells into the milieu of a traumatic spinal cord injury. The computational flexibility and plasticity of the sensorimotor systems of the brain, spinal cord, and motor unit make functional use of new circuitry feasible in patients. To incorporate residual and new pathways, neural repair strategies must be coupled to rehabilitation therapies that drive activity-dependent plasticity for walking, for reaching and grasping, and for bowel and bladder control. Prevention of pain and dysautonomia are also clinical targets. Research aims to define the temporal windows of opportunity for interventions, test the safety and efficacy of delivery systems of agents and cells, and provide a better understanding of the cascades of gene expression and cell interactions both acutely and chronically after injury. These bench-to-bedside studies are defining the neurobiology of spinal cord injury rehabilitation. PMID:14746521

  3. Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research

    PubMed Central

    Kipps, Emma; Tan, David S. P.; Kaye, Stan B.

    2015-01-01

    Malignant ascites presents a considerable clinical challenge to the management of ovarian cancer, but also provides a wealth of opportunities for translational research. The accessibility of ascitic fluid and its cellular components make it an excellent source of tumour tissue for the investigation of prognostic and predictive biomarkers, pharmacodynamic markers and for molecular profiling analysis. In this Opinion article, we discuss recent advances in our understanding of its pathophysiology, the development of new methods to characterize its molecular features and how these findings can be used to improve the treatment of malignant ascites, particularly in the context of ovarian cancer. PMID:23426401

  4. Composite Avenue beyond the Standard Model ---Legacy of Sakata in LHC Era---

    NASA Astrophysics Data System (ADS)

    Yamawaki, K.

    Higgs boson may be a composite particle as Sakata vigorously looked for never-ending substructures of Nature. He proposed the Sakata model for hadrons, which was the prototype of the quark model and thus lauched the last Revolution in particle physics continued all the way up to Kabayashi-Maskawa work which completed the Standard Model today. Inspired by Sakata's spirit we shall discuss composite Higgs boson in various models of our own for the dynamical symmetry breaking with large anomalous dimension: The techni-dilaton in the walking technicolor (WTC) with gamma_m ≃ 1, the bar t t composite (``top-Higgs'') in the top-quark condensate model with gamma_m ≃ 2, and their variants in the models with 1 < gamma_m < 2 (strong ETC Technicolor, etc.). Among others we will focus on WTC which has an approximate scale symmetry in the region relevant to the dynamical mass generation. Such a conformal gauge dynamics is characterized by the essential singularity scaling, breakdown of the Ginzburg-Landau/Gell-Mann-Levy effective theory, and also by a large anomalous dimension gamma_m = 1. In contrast to the folklore that Technicolor is a ``Higgsless theory'', there exists a composite Higgs, techni-dilaton, in the WTC as a composite pseudo Nambu-Goldstone boson associated with the spontaneously broken (approximate) scale symmetry, with its mass only arising from the (nonperturbative) scale anomaly and hence being much smaller than those of other techni-hadrons. The techni-dilaton has a mass typically of order 500-600 GeV and can be discovered at LHC. We shall also touch upon the endeavor to discover WTC on the lattice.

  5. Avenues and incentives for commercial use of a low-gravity environment

    NASA Technical Reports Server (NTRS)

    Brown, R. L.; Zoller, L. K.

    1981-01-01

    The scientific and commercial utilization of the low-g environments for materials research and for process and product development is considered. Any products of commercial interest which necessitate processing in space will probably be low volume, high value items. To encourage the commercialization of materials processing in low-g, NASA, in parallel with establishing and demonstrating the scientific/technological precepts for analyzing and using a low-g environment, is establishing the legal and management mechanisms to share in the cost and risk of early commercial ventures, and is now working with commercial firms on a case-by basis to explore applications of this new technology to specific needs of the company.

  6. Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin?

    PubMed

    Yousaf, Farhanah; Spinowitz, Bruce

    2016-03-01

    Anemia of chronic kidney disease (CKD) is common and is associated with diminished quality of life, cognitive impairment, cardiovascular morbidity, hospitalizations, and mortality. As the prevalence of end-stage renal disease continues to rise, the management of anemia represents a growing economic burden. Erythropoiesis-stimulating agents (ESA) are the mainstay of anemia management but their use is limited due to the associated cardiovascular adverse events. Prolyl hydroxylase domain enzyme (PHD) inhibitors are a new class of drugs that stabilize the hypoxia-inducible factors and are under clinical investigation for the treatment of renal anemia. The advantages of PHD inhibitors include the oral route of administration, improved iron profile, restoration of diurnal rhythm of erythropoietin secretion, and endogenous erythropoietin production near physiological range. Emerging but limited data indicates a small blood pressure lowering effect of PHD inhibitors. The effect of PHD inhibitors on cardiovascular endpoints and the potential risks of CKD progression and pulmonary hypertension remains to be addressed in the ongoing clinical trials. PMID:26894597

  7. Developing effective, culturally appropriate avenues to FASD diagnosis and prevention in northern Canada.

    PubMed

    Salmon, Amy; Clarren, Sterling K

    2011-09-01

    This article describes 2 research initiatives that are being undertaken by members of the Canada Northwest FASD Research Network, involving collaborations between researchers, clinicians, service providers and community members in the Canadian North. Improving both the diagnosis and prevention of FASD requires evidence-based approaches to clinical and social service delivery that are capable of accounting for the unique contours of the geographic, regional and cultural diversities in which women become pregnant and in which families live. Although FASD has been a priority for communities and governments in northern Canada, research capacity has not been available to support the development of the context-specific knowledge needed to inform policy and practice in this region. Moreover, there have not been adequate mechanisms for transferring practice-based knowledge from the Canadian North to researchers and service providers in the South, who might make use of this knowledge to inform their own practice. Herein, we highlight the ways in which reciprocal knowledge exchange involving CanFASD Northwest researchers at academic health science centres and diverse stakeholder groups is supporting multi-directional capacity building in FASD diagnosis and prevention. PMID:21878184

  8. Pendular Proteins in Gases and New Avenues for Characterization of Macromolecules by Ion Mobility Spectrometry

    SciTech Connect

    Shvartsburg, Alexandre A.; Noskov, Sergei; Purves, Randy; Smith, Richard D.

    2009-04-21

    Polar molecules align in electric fields when the dipole energy (proportional to field intensity E × dipole moment p) exceeds the thermal rotational energy. Small molecules have low p and align only at inordinately high E or upon extreme cooling. Many biomacromolecules and ions are strong permanent dipoles and may align at E achievable in gases and room temperature. The collision cross sections of aligned ions with gas molecules generally differ from orientationally averaged quantities, affecting ion mobilities measured in ion mobility spectrometry (IMS). Field asymmetric waveform IMS (FAIMS) separates ions by the difference between mobilities at high and low E and hence can resolve and identify macroion conformers based on the mobility difference between pendular and free rotor states. An exceptional sensitivity of that difference to the ion geometry and charge distribution holds the potential for a powerful new method for separation and characterization of macromolecular species. Theory predicts that the pendular alignment of ions in gases at any E requires a minimum p depending on the ion mobility, gas pressure, and temperature. At ambient conditions used in current FAIMS systems, the p for realistic ions must exceed ~300 - 400 Debye. The dipole moments of proteins statistically increase with increasing mass, and such values are typical above ~30 kDa. FAIMS analyses of protein ions and complexes of ~30 - 130 kDa show an order-of-magnitude expansion of separation space compared to smaller proteins and other ions, consistent with expectations for the dipole-aligned regime.

  9. Peer Contexts in Schools: Avenues Toward Behavioral Health in Early Adolescence.

    PubMed

    Cappella, Elise; Hwang, Sophia H J

    2015-01-01

    Peer contexts play an important role in the behavioral health of early adolescents in schools. Behavioral health involves the observable academic and social behaviors that relate to and influence youths' subsequent health and development. Setting-level research on peer networks and social norms indicates these aspects of peer contexts vary by peer group, classroom, and school and dynamically relate to individual students' academic and social behaviors. Yet, although peer contexts are both influential and potentially malleable, little research examines the effects of school and classroom interventions on the development and maintenance of positive and productive peer contexts in schools. The current article identifies school structures and classroom processes theorized to directly or indirectly shift peer networks and social norms-and thereby increase the behavioral health of early adolescents in schools. We discuss the need for more rigorous and relevant research to better understand the role of schools and classrooms in strengthening these peer contexts and promoting behavioral health in early adolescence. PMID:26332925

  10. New avenues to efficient chemical synthesis of exchange coupled hard/soft nanocomposite magnet.

    PubMed

    Lee, Don Keun; Cha, Hyun Gil; Kim, Young Hwan; Kim, Chang Woo; Ji, Eun Sun; Kang, Young Soo

    2009-07-01

    Nd-Fe-B ultrafine amorphous alloy particles were prepared by reaction of metal ions with borohydride in aqueous solution. Monodispersed Fe nanoparticles were synthesized under an argon atmosphere via thermal decomposition of Fe(2+)-oleate2. Exchange coupled Nd2Fe14B/Fe nanocomposite magnets have been prepared by self-assembly using surfactant. The crystal structure of the synthesized nanoparticles was identified by using X-ray powder diffraction (XRD). The size and shape of nanoparticles were obtained by transmission electron microscope (TEM). Thermogravimetry using a microbalance with magnetic field gradient positioned below the sample was used for the measurement of a thermomagnetic analysis (TMA) curve showing the downward magnetic force versus temperature. PMID:19916473

  11. Is Emotional Working Memory Training a New Avenue of AD Treatment? A review.

    PubMed

    Mammarella, Nicola

    2014-02-01

    Emotional working memory training is a new area of research. In this study, we review a series of recent works describing a range of emotional working memory interventions that go from training single affective working memory function to teaching emotion regulation strategies. Generally speaking, research to date has established that emotional working memory may be preserved in Alzheimer's disease. However, much work remains to be done in clarifying what aspects of affective domain is preserved, and testing short- and long-term effects of the trainings as well as their generalization to everyday affective functioning. We conclude by offering suggestions about the development of emotional working memory training for Alzheimer's patients. PMID:24490115

  12. Electric Avenue. A Utility Company's Work Experience Program Broadens Opportunities for Students.

    ERIC Educational Resources Information Center

    Ingles, Pat

    1994-01-01

    A job skills partnership between Southern California Edison Company and local high schools pairs juniors and seniors with journeyworker mentors for a year, experiencing six-week rotations in maintenance, operations, administration, warehouse, and technical occupations. (JOW)

  13. Mesenchymal stem cell-derived exosomes: A novel potential therapeutic avenue for cardiac regeneration.

    PubMed

    Safari, S; Malekvandfard, F; Babashah, S; Alizadehasl, A; Sadeghizadeh, M; Motavaf, M

    2016-01-01

    Coronary artery diseases (CADs) represent a significant cause of death worldwide. During recent decades the rate of cardiovascular mortality has been declined as a result of modern medicine and surgery. However, despite the fact that cardiac cells, including cardiomyocytes (CMCs), vascular smooth muscle cells (VSMC) and vascular endothelial cells (VEC), can be regenerated by cardiac adult stem cell, the regenerative capacity of these cells are limited and inadequate to functionally regenerate heart damaged tissue. Thus, growth reserve of the heart fails to restore the structural integrity of the myocardium after infarction and healing is associated with scar formation. An explanation for this is that cardiac reside stem cells are present throughout the infarction site but die rapidly by apoptosis. Furthermore, microenvironment surrounding the damage site is not promising for the cells survival and renewal. Hence, recent advances in the stem cell therapy have emerged as an attractive approach to replace the lost cells. In this context, mesenchymal stem cells (MSCs) has considered as one of the most promising candidates for regeneration of cardiac cells, lost upon injury. The regenerative capacity of MSCs has primarily been centered on the hypothesis that these cells would engraft, differentiate and replace damaged cardiac cells. However, experimental and clinical observations so far have failed to establish if this differentiated is considerably relevant to MSCs cardiac regenerative properties. Recent reports have suggested that these therapeutic properties, at least in part, are mediated by paracrine factors released from MSCs. This review provides a concise summary of current evidences supporting the paracrine hypothesis of MSCs. In particular, the scope of this review focuses on the role of MSC-derived exosome (MSC-EXs) as a therapeutic modality for the treatment of CADs, particularly ischemic myocardial dysfunctions. PMID:27453275

  14. Technical and Vocational Education in Cameroon and Critical Avenues for Development

    ERIC Educational Resources Information Center

    Che, S. Megan

    2007-01-01

    Technical and vocational education (TVE) can influence development and economic progress for post-colonial societies. Some newly independent sub-Saharan African countries attempted curricular transformation that might produce a skilled workforce through widespread access to versions of TVE. In Cameroon, no such post-colonial curricular revolution…

  15. Dual Diaspora and Barrio Art: Art as an Avenue for Learning English

    ERIC Educational Resources Information Center

    Craig, Dorothy Valcarcel; Paraiso, Johnna

    2008-01-01

    This study examined student artwork as free expression in order to conduct an analysis of diaspora as related to urban, middle school students learning English. Subjects consisted of middle school students representing a variety of countries with Spanish being the primary first language of the majority of participants. Using a qualitative approach…

  16. Implementing and Simulating Dynamic Traffic Assignment with Intelligent Transportation Systems in Cube Avenue

    NASA Technical Reports Server (NTRS)

    Foytik, Peter; Robinson, Mike

    2010-01-01

    As urban populations and traffic congestion levels increase, effective use of information and communication tools and intelligent transportation systems as becoming increasingly important in order to maximize the efficiency of transportation networks. The appropriate placement and employment of these tools within a network is critical to their effectiveness. This presentation proposes and demonstrates the use of a commercial transportation simulation tool to simulate dynamic traffic assignment and rerouting to model route modifications as a result of traffic information.

  17. Re-experiencing traumatic events in PTSD: new avenues in research on intrusive memories and flashbacks

    PubMed Central

    Brewin, Chris R.

    2015-01-01

    Posttraumatic flashbacks, consisting of the intrusive re-experiencing of traumatic experiences in the present, have been more clearly defined for the first time in DSM-5 and have been identified as a unique symptom of posttraumatic stress disorder in the proposed ICD-11 diagnostic criteria. Relatively little research into flashbacks has been conducted, however, and new research efforts are required to understand the cognitive and biological basis of this important symptom. In addition, there is considerable scope for research into how flashbacks should be assessed and into flashbacks occurring in different contexts, such as psychosis or intensive care. PMID:25994019

  18. 76 FR 55701 - Landmarks Committee of the National Park System Advisory Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... County, AZ. Poston Elementary School, Unit I, La Paz County, AZ. California Nuestra Se ora Reina De La Paz, Kern County, CA. Port of Nova Albion Historic and Archeological District, Marin County,...

  19. Polyglutamine aggregate structure in vitro and in vivo; new avenues for coherent anti-Stokes Raman scattering microscopy.

    PubMed

    Perney, Nicolas M; Braddick, Lucy; Jurna, Martin; Garbacik, Erik T; Offerhaus, Herman L; Serpell, Louise C; Blanch, Ewan; Holden-Dye, Lindy; Brocklesby, William S; Melvin, Tracy

    2012-01-01

    Coherent anti-Stokes Raman scattering (CARS) microscopy is applied for the first time for the evaluation of the protein secondary structure of polyglutamine (polyQ) aggregates in vivo. Our approach demonstrates the potential for translating information about protein structure that has been obtained in vitro by X-ray diffraction into a microscopy technique that allows the same protein structure to be detected in vivo. For these studies, fibres of polyQ containing peptides (D(2)Q(15)K(2)) were assembled in vitro and examined by electron microscopy and X-ray diffraction methods; the fibril structure was shown to be cross β-sheet. The same polyQ fibres were evaluated by Raman spectroscopy and this further confirmed the β-sheet structure, but indicated that the structure is highly rigid, as indicated by the strong Amide I signal at 1659 cm(-1). CARS spectra were simulated using the Raman spectrum taking into account potential non-resonant contributions, providing evidence that the Amide I signal remains strong, but slightly shifted to lower wavenumbers. Combined CARS (1657 cm(-1)) and multi-photon fluorescence microscopy of chimeric fusions of yellow fluorescent protein (YFP) with polyQ (Q40) expressed in the body wall muscle cells of Caenorhabditis elegans nematodes (1 day old adult hermaphrodites) revealed diffuse and foci patterns of Q40-YFP that were both fluorescent and exhibited stronger CARS (1657 cm(-1)) signals than in surrounding tissues at the resonance for the cross β-sheet polyQ in vitro. PMID:22911702

  20. Momentum and Turbulent Kinetic Energy Budgets Within the Park Avenue Street Canyon During the Joint Urban 2003 Field Campaign

    NASA Astrophysics Data System (ADS)

    Nelson, Matthew A.; Pardyjak, Eric R.; Klein, Petra

    2011-07-01

    Very few attempts have so far been made to quantify the momentum and turbulent kinetic energy (TKE) budgets within real urban canopies. In this study, sonic anemometer data obtained during the Joint Urban 2003 field campaign in Oklahoma City, U.S.A. were used for calculating the momentum and TKE budgets within a real-world urban street canyon. Sonic anemometers were deployed on multiple towers in the lower half of the canyon. Gradients in all three principal directions were included in the analyses. The storage and buoyancy terms were found to have negligible contributions to both the momentum and TKE budgets. The momentum budgets were generally found to be more complex than a simple balance of two physical processes. The horizontal terms were found to have significant and sometimes dominant contributions to the momentum and TKE budgets.

  1. PET and SPECT imaging of the opioid system: receptors, radioligands and avenues for drug discovery and development.

    PubMed

    Lever, John R

    2007-01-01

    As we celebrate the bicentennial of the isolation of morphine by Sertürner, opioids continue to dominate major sectors of the analgesic market worldwide. The pharmaceutical industry stands to benefit greatly from molecular imaging in preclinical and early clinical trials of new or improved opioid drugs. At this juncture, it seems fitting to summarize the past twenty or so years of research on molecular imaging of the opioid system from the viewpoint of drug discovery and development. Opioid receptors were first imaged in human volunteers by positron emission tomography (PET) in 1984. Now, quantitative PET imaging of the major opioid receptor types (micro, delta , kappa) is possible in the brain and peripheral organs of healthy persons and patient populations. Radioligands are under development for single photon emission computed tomography (SPECT) of opioid receptors as well. These functional, nuclear imaging techniques can trace the fate of radiolabeled molecules directly, but non-invasively, and allow precise pharmacokinetic and pharmacodynamic measurements. Molecular imaging provides unique data that can aid in selecting the best drug candidates, determining optimal dosing regimens, clearing regulatory hurdles and lowering risks of failure. Using a historical perspective, this review touches on opioid receptors as drug targets, and focuses on the status and use of radiotracers for opioid receptor PET and SPECT. Selected studies are discussed to illustrate the power of molecular imaging for facilitating opioid drug discovery and development. PMID:17266587

  2. 75 FR 11914 - Chrysler, LLC, Mack Avenue Engine Plants 1 & 2, Power Train Division, Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Division, Detroit, Michigan. The notice was published in the Federal Register on December 18, 2008 (73 FR..., Including On-Site Leased Workers From Caravan Knight Facilities Management LLC; Detroit, MI; Amended... Jeep Grand Cherokee. New information shows that workers leased from Caravan Knight...

  3. Super Searchers on Madison Avenue: Top Advertising and Marketing Professionals Share Their Online Research Strategies. Super Searchers, Volume XI.

    ERIC Educational Resources Information Center

    Villamora, Grace Avellana

    This book presents interviews with 13 research professionals that contain favorite online search strategies and research tools, anecdotes, "how to" survival tips, and best-practice examples. The appendix lists referenced sites and sources in the following categories: (1) online resources; (2) books, annuals, newsletters, magazines, and articles;…

  4. Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?

    PubMed Central

    Titova, Lyubov V.; Ayesheshim, Ayesheshim K.; Golubov, Andrey; Rodriguez-Juarez, Rocio; Woycicki, Rafal; Hegmann, Frank A.; Kovalchuk, Olga

    2013-01-01

    Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum and is non-ionizing. We show that exposure of artificial human skin tissue to intense, picosecond-duration THz pulses affects expression levels of numerous genes associated with non-melanoma skin cancers, psoriasis and atopic dermatitis. Genes affected by intense THz pulses include nearly half of the epidermal differentiation complex (EDC) members. EDC genes, which are mapped to the chromosomal human region 1q21, encode for proteins that partake in epidermal differentiation and are often overexpressed in conditions such as psoriasis and skin cancer. In nearly all the genes differentially expressed by exposure to intense THz pulses, the induced changes in transcription levels are opposite to disease-related changes. The ability of intense THz pulses to cause concerted favorable changes in the expression of multiple genes implicated in inflammatory skin diseases and skin cancers suggests potential therapeutic applications of intense THz pulses. PMID:23917523

  5. Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons.

    PubMed

    Sampedro-Piquero, P; Castilla-Ortega, E; Zancada-Menendez, C; Santín, L J; Begega, A

    2016-08-25

    The use of more ethological animal models to study the neurobiology of anxiety has increased in recent years. We assessed the effect of an environmental enrichment (EE) protocol (24h/day over a period of two months) on anxiety-related behaviors when aged Wistar rats (21months old) were confronted with cat odor stimuli. Owing to the relationship between GABAergic interneurons and the anxiety-related neuronal network, we examined changes in the expression of Parvalbumin (PV) and 67kDa form of glutamic acid decarboxylase (GAD-67) immunoreactive cells in different brain regions involved in stress response. Behavioral results revealed that enriched rats traveled further and made more grooming behaviors during the habituation session. In the cat odor session, they traveled longer distances and they showed more active interaction with the odor stimuli and less time in freezing behavior. Zone analysis revealed that the enriched group spent more time in the intermediate zone according to the proximity of the predator odor. Regarding the neurobiological data, the EE increased the expression of PV-positive cells in some medial prefrontal regions (cingulate (Cg) and prelimbic (PL) cortices), whereas the GAD-67 expression in the basolateral amygdala was reduced in the enriched group. Our results suggest that EE is able to reduce anxiety-like behaviors in aged animals even when ethologically relevant stimuli are used. Moreover, GABAergic interneurons could be involved in mediating this resilient behavior. PMID:27235742

  6. Changing Course: Thurgood Marshall College Fund President Johnny Taylor Seeks New Partnerships and Avenues of Support for Public HBCUs

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    When veteran educator Dr. N. Joyce Payne handed the reins of the organization she founded, the Thurgood Marshall College Fund, to entertainment lawyer and board member Johnny Taylor, Taylor began pursuing a remake of the prestigious group that has turned it on its head in just a matter of months. Today, with just more than a year of leading the…

  7. Electroretinographic modifications induced by agomelatine: a novel avenue to the understanding of the claimed antidepressant effect of the drug?

    PubMed Central

    Fornaro, Michele; Bandini, Fabio; Cestari, Luca; Cordano, Christian; Ogliastro, Carla; Albano, Claudio; De Berardis, Domenico; Martino, Matteo; Escelsior, Andrea; Rocchi, Giulio; Fornaro, Pantaleo; De Pasquale, Concetta

    2014-01-01

    Background Agomelatine, the first melatonergic antidepressant, has been postulated to enhance the dopaminergic activity at the central nervous system by 5-hydroxytryptamine receptor type 2C (5-HT2C) antagonism, yet the impact of melatonergic agonism on this pathway is unclear. Previous studies employing simplified, yet reliable, proxy (retinal) measures of the central nervous system dopaminergic activity, namely the standard electroretinogram (ERG) technique, suggested a reduction of the dopaminergic activity of the main ERG parameter, the b-wave, by pure melatonin, notably a hormone devoid of any antidepressant activity. Therefore, the antidepressant effects of the melatonergic antidepressant drug agomelatine should be reflected by a differential b-wave trend at ERG versus the effect exerted by pure melatonin, which was eventually found to be due to a contrasting effect on central dopaminergic transmission between the two drugs. Objective and methods The aim of the present preliminary ERG study carried out on healthy volunteers (n=23) receiving agomelatine was to explore the impact of this antidepressant drug on b-wave amplitude and latency of cones in daylight conditions using standard ERG. Results As postulated, agomelatine induced an enhancement of retinal dopaminergic activity, in contrast to what has been previously documented for melatonin. Conclusion Given the limits of this explorative study, especially the lack of a control group and that of a luminance response function to measure retinal sensitivity, further studies in clinical samples are recommended to allow more tenable conclusions about the potential role of ERG in discriminating between 5-HT antagonism and melatonergic (MT) agonism in relationship to the claimed antidepressant effect of agomelatine. PMID:24899809

  8. Constraints, synergies and avenues for scaling up breastfeeding, antibiotics for pneumonia and IMCI interventions in the Cusco region, Peru

    PubMed Central

    Gericke, Christian A

    2012-01-01

    Objective: The purpose of this qualitative case study was to assess the feasibility of scaling up exclusive breastfeeding for 6 months, antibiotics for pneumonia and integrated management of childhood illness (IMCI) child interventions in three districts of the Cusco region, Peru. Methods: During field visits, constraints, synergies and solutions to the implementation of the selected interventions were collected through observational recording and interviews of mothers, health workers, and health managers/decision makers. Results are presented for each intervention according to the health system level where they occurred: mother/community, health worker, health centre, and political/managerial levels. Findings: This case study demonstrates that it is feasible to scale up exclusive breastfeeding, antibiotics for pneumonia and IMCI interventions in poverty-stricken rural areas of a low-income country. Factors that helped and hindered the implementation were identified for each intervention. Conclusions: The need for a coherent multi-sector approach that includes regulation, implementation and monitoring of health policies and education of all involved stakeholders was apparent. This study also demonstrates that global health interventions need to undergo local adaptation. Identifying local constraints and facilitating factors in a systematic way as proposed in this study is a useful step to increase their effectiveness and reach at the local level and to identify areas for improvement in the original intervention policies. PMID:24358831

  9. A novel potential therapeutic avenue for autism: Design, synthesis and pharmacophore generation of SSRIs with dual action

    PubMed Central

    Ghoneim, Ola M.; Ibrahim, Diaa A.; El-Deeb, Ibrahim M.; Lee, So Ha; Booth, Raymond G.

    2014-01-01

    Autism symptoms are currently modulated by Selective Serotonin Reuptake Inhibitors (SSRIs). SSRIs slow onset of action limits their efficiency. The established synergistic activity of SSRIs and 5HT1B/1D autoreceptors antagonists motivated us to incorporate SSRIs and 5HT1B/1D antagonists in one ‘hybrid’ molecule. A library of virtual ‘hybrid’ molecules was designed using the tethering technique. A pharmacophore model was generated derived from 16 structurally diverse SSRIs (Ki = 0.013–5000 nM) and used as 3D query. Compounds with fit values (≥2) were chosen for synthesis and subsequent in vitro biological evaluation. Our pharmacophore model is a promising milestone to a class of SSRIs with dual action. PMID:21982496

  10. Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues

    PubMed Central

    Dravis, Christopher; Henkemeyer, Mark

    2011-01-01

    We report that the disruption of bidirectional signaling between ephrin-B2 and EphB receptors impairs morphogenetic cell-cell septation and closure events during development of the embryonic midline. A novel role for reverse signaling is identified in tracheoesophageal foregut septation, as animals lacking the cytoplasmic domain of ephrin-B2 present with laryngotracheoesophageal cleft (LTEC), while both EphB2/EphB3 forward signaling and ephrin-B2 reverse signaling are shown to be required for midline fusion of the palate. In a third midline event, EphB2/EphB3 are shown to mediate ventral abdominal wall closure by acting principally as ligands to stimulate ephrin-B reverse signaling. Analysis of new ephrin-B26YFΔV and ephrin-B2ΔV mutants that specifically ablate ephrin-B2 tyrosine phosphorylation- and/or PDZ domain-mediated signaling indicate there are at least two distinct phosphorylation-independent components of reverse signaling. These involve both PDZ domain interactions and a non-canonical SH2/PDZ-independent form of reverse signaling that may utilize associations with claudin family tetraspan molecules, as EphB2 and activated ephrin-B2 molecules are specifically co-localized with claudins in epithelia at the point of septation. Finally, the developmental phenotypes described here mirror common human midline birth defects found with the VACTERL association, suggesting a molecular link to bidirectional signaling through B-subclass Ephs and ephrins. PMID:21539827

  11. A Random Walk Down University Avenue: Life Paths, Life Events, and Personality Trait Change at the Transition to University Life

    PubMed Central

    Lüdtke, Oliver; Roberts, Brent W.; Trautwein, Ulrich; Nagy, Gabriel

    2013-01-01

    This longitudinal study examined the relation between continuity and change in the Big Five personality traits and life events. Approximately 2,000 German students were tracked from high school to university or to vocational training or work, with 3 assessments over 4 years. Life events were reported retrospectively at the 2nd and 3rd assessment. Latent curve analyses were used to assess change in personality traits, revealing 3 main findings. First, mean-level changes in the Big Five factors over the 4 years were in line with the maturity principle, indicating increasing psychological maturity from adolescence to young adulthood. Second, personality development was characterized by substantive individual differences relating to the life path followed; participants on a more vocationally oriented path showed higher increases in conscientiousness and lower increases in agreeableness than their peers at university. Third, initial level and change in the Big Five factors (especially Neuroticism and Extraversion) were linked to the occurrence of aggregated as well as single positive and negative life events. The analyses suggest that individual differences in personality development are associated with life transitions and individual life experiences. PMID:21744977

  12. (13)CHD2-CEST NMR spectroscopy provides an avenue for studies of conformational exchange in high molecular weight proteins.

    PubMed

    Rennella, Enrico; Huang, Rui; Velyvis, Algirdas; Kay, Lewis E

    2015-10-01

    An NMR experiment for quantifying slow (millisecond) time-scale exchange processes involving the interconversion between visible ground state and invisible, conformationally excited state conformers is presented. The approach exploits chemical exchange saturation transfer (CEST) and makes use of (13)CHD2 methyl group probes that can be readily incorporated into otherwise highly deuterated proteins. The methodology is validated with an application to a G48A Fyn SH3 domain that exchanges between a folded conformation and a sparsely populated and transiently formed unfolded ensemble. Experiments on a number of different protein systems, including a 360 kDa half-proteasome, establish that the sensitivity of this (13)CHD2 (13)C-CEST technique can be upwards of a factor of 5 times higher than for a previously published (13)CH3 (13)C-CEST approach (Bouvignies and Kay in J Biomol NMR 53:303-310, 2012), suggesting that the methodology will be powerful for studies of conformational exchange in high molecular weight proteins. PMID:26271302

  13. Exploratory studies of new avenues to achieve high electromechanical response and high dielectric constant in polymeric materials

    NASA Astrophysics Data System (ADS)

    Huang, Cheng

    High performance soft electronic materials are key elements in advanced electronic devices for broad range applications including capacitors, actuators, artificial muscles and organs, smart materials and structures, microelectromechanical (MEMS) and microfluidic devices, acoustic devices and sensors. This thesis exploits new approaches to improve the electromechanical response and dielectric response of these materials. By making use of novel material phenomena such as large anisotropy in dipolar response in liquid crystals (LCs) and all-organic composites in which high dielectric constant organic solids and conductive polymers are either physically blended into or chemically grafted to a polymer matrix, we demonstrate that high dielectric constant and high electromechanical conversion efficiency comparable to that in ceramic materials can be achieved. Nano-composite approach can also be utilized to improve the performance of the electronic electroactive polymers (EAPs) and composites, for example, exchange coupling between the fillers and matrix with very large dielectric contrast can lead to significantly enhance the dielectric response as well as electromechanical response when the heterogeneity size of the composite is comparable to the exchange length. In addition to the dielectric composites, in which high dielectric constant fillers raise the dielectric constant of composites, conductive percolation can also lead to high dielectric constant in polymeric materials. An all-polymer percolative composite is introduced which exhibits very high dielectric constant (>7,000). The flexible all-polymer composites with a high dielectric constant make it possible to induce a high electromechanical response under a much reduced electric field in the field effect electroactive polymer (EAP) actuators (a strain of 2.65% with an elastic energy density of 0.18 J/cm3 can be achieved under a field of 16 V/mum). Agglomeration of the particles can also be effectively prevented by in situ preparation. High dielectric constant copper phthalocyanine oligomer and conductive polyaniline oligomer were successfully bonded to polyurethane backbone to form fully functionalized nano-phase polymers. Improvement of dispersibility of oligomers in polymer matrix makes the system self-organize the nanocomposites possessing oligomer nanophase (below 30nm) within the fully functionalized polymers. The resulting nanophase polymers significantly enhance the interface effect, which through the exchange coupling raises the dielectric response markedly above that expected from simple mixing rules for dielectric composites. Consequently, these nano-phase polymers offer a high dielectric constant (a dielectric constant near 1,000 at 20 Hz), improve the breakdown field and mechanical properties, and exhibit high electromechanical response. A longitudinal strain of more than -14% can be induced under a much reduced field, 23 V/mum, with an elastic energy density of higher than 1 J/cm3. The elastic modulus is as high as 100MPa, and a transverse strain is 7% under the same field. (Abstract shortened by UMI.)

  14. Radiological assessment report for the University of Rochester Annex, 400 Elmwood Avenue, Rochester, New York, April-May 1984

    SciTech Connect

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Flynn, K.F.

    1984-12-01

    In light of the results of the comprehensive radiological assessment of the annex and auxiliary facilities, the following conclusions can be made: There is no immediate hazard from the elevated levels of radioactivity detected; however, some of these levels are above criteria. The radon, thoron, actinon, long-lived particulates, and tritium in the air are all below criteria for unrestricted use. Some ductwork has been identified as being contaminated. All ductwork must, therefore, be considered potentially contaminated. Since several floor drains were found to exhibit elevated readings, and the samples had elevated concentrations of radionuclides, it must be concluded that the drain and sewer systems of the Annex are contaminated with radioactive material. Since the samples collected from the storm and sewer systems outside the building also had elevated concentrations of radionuclides, these systems are also considered contaminated with radioactive material. The grounds around the Annex have exhibited background concentrations of radionuclides. Two rooms, B-330 and B-332, were inaccessible for survey due to the presence of stored furniture and equipment. Therefore, no comment about their radiological status can be made. At the common baseboard for Room C-12 and C-16 and on the floor below the tile in Room C-40, contamination appeared to be masked by construction modifications. Other areas of the Annex must also be considered potentially contaminated where modifications may have masked the contamination.

  15. New avenues for improving pancreatic ductal adenocarcinoma (PDAC) treatment: Selective stroma depletion combined with nano drug delivery.

    PubMed

    Bhaw-Luximon, Archana; Jhurry, Dhanjay

    2015-12-28

    The effectiveness of chemotherapy in PDAC is hampered by the dynamic interaction between stroma and cancer cell. The two opposing schools of thought - non-depletion of the stroma vs its depletion - to better drug efficacy are here discussed. Disrupting stroma-cancer cell interaction to reduce tumor progression and promote apoptosis is identified as the new direction of treatment for PDAC. Clinical data have shown that elimination of fibrosis and blockade of the Hedgehog pathway in stroma effectively promote drug delivery to tumor site and apoptosis. Reduced stiffness of ECM, lower fibrosis, higher permeability and higher blood flow after stroma depletion increase drug delivery. Combination strategies involving selective stroma depletion coupled with chemotherapy is currently proving to be the most efficient at clinical level. Striking the right balance between fibrosis depletion and angiogenesis promotion resulting in enhanced drug delivery and apoptosis is a major challenge. The use of nano drug delivery devices coupled with stroma depletion is emerging as the next phase treatment for PDAC. The breakthrough to combat PDAC will likely be a combination of early diagnosis and the emerging chemotherapy strategies. PMID:26415628

  16. To homogenize, or not to homogenize, that is the question: Quartz-hosted melt inclusion analysis avenues

    NASA Astrophysics Data System (ADS)

    Mercer, C. N.; Roberge, J.; Todorov, T. I.; Hofstra, A. H.

    2013-12-01

    Melt inclusions hosted in quartz can provide the only direct information about the pressure, temperature, and melt composition of pre-eruptive rhyolitic magmas, many of which are the precursors to mineralizing aqueous fluids [1]. With ideal, rapidly-quenched pumice samples, analysis of glassy quartz-hosted melt inclusions is relatively straightforward. These data can be directly interpreted to represent snapshots of metal and volatile concentrations during magma crystallization and degassing. However, most ore deposit-related igneous samples are non-ideal; being older, potentially hydrothermally altered, and often crystallized due to slow cooling in subvolcanic regions (e.g., porphyry-type deposits). In this case, analysis of crystalline melt inclusions in quartz is not straightforward and resulting data must be meticulously examined before interpretation. Many melt inclusions may have experienced post-entrapment modifications [1] such as diffusion of elements (e.g., H, Li, Na, Ag, Cu) [2], which may lead to changes in measured oxygen fugacity. Slowly cooled inclusions may crystallize, producing a heterogeneous "micro-rock" that cannot be analyzed by spectroscopic methods or electron microprobe. While crystallized inclusions can be homogenized in a high-temperature furnace, many new problems may arise such as inclusion decrepitation [3], diffusion of elements [2], and incorporation of too little or too much Si from the inclusion rim or host crystal. However, if unwanted homogenization effects are minimized by choosing ideal experimental conditions, then these homogenized inclusions can be analyzed by traditional FTIR and electron microprobe methods. The electron microprobe data from homogenized inclusions can be used as accurate internal standards for laser ablation-ICP-MS data reduction. Alternatively, crystalline inclusions can be directly analyzed for major and trace elements by laser ablation-ICP-MS [4], which considerably reduces sample preparation time, but requires the critical assumption of an internal standard value in order to extract elemental concentrations from mass spectrometry counts. We present and compare examples of analysis techniques for both ideal (e.g., Bishop Tuff) and non-ideal (e.g., Hideaway Park rhyolite) sample suites, and discuss the assumptions and sacrifices made to maximize the information that can be collected from melt inclusions. Though non-ideal melt inclusion samples present many analytical challenges, they preserve a valuable (and in some cases the only) source of information regarding magmatic processes leading to ore formation. [1] Audétat (in press) Geochemistry of Mineral Resources: Treatise of Geochemistry, 2nd edition. [2] Zajacz (2009) Geochimica et Cosmochimica Acta, 73, 3013-3027. [3] Bodnar (2006) Melt Inclusions in Plutonic Rocks, 36, 1-25. [4] Halter (2002) Chemical Geology, 183, 63-86.

  17. ASSESSING UST CORRECTIVE ACTION TECHNOLOGIES: LESSONS LEARNED ABOUT IN SITU AIR SPARGING AT THE DENISON AVENUE - CLEVELAND, OH

    EPA Science Inventory

    In situ air sparging (IAS) has been used at an increasing number of sites to address groundwater contamination. ecause of the lack of substantive performance data, however, the actual effectiveness of this system is not known. he EPA Office of Research and Development Risk Reduct...

  18. Radiation-induced carboxylation of chloroacetate ion: An avenue for making value-added products from carbon dioxide

    SciTech Connect

    Getoff, N.

    1997-12-31

    The major theme of this paper is the radiation-induced carboxylation monochloroacetic acid. The formation of various products originating from chloroacetate ion, CO{sub 2}, CO or/and formate was studied as a function of substrate concentration, absorbed radiation dose etc. Malonic acid and oxalic acid were found to be the major products in addition to succinic, maleic and citric acids. Small yields of other organic compounds were also found. The results from these studies will be reported.

  19. Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions

    PubMed Central

    Makarev, Evgeny; Cantor, Charles; Zhavoronkov, Alex; Buzdin, Anton; Aliper, Alexander; Csoka, Antonei Benjamin

    2014-01-01

    Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, “AMD Medicine”, and discovered differential pathway activation profiles in samples of human RPE/choroid from AMD patients and controls. We identified 29 pathways in RPE-choroid AMD phenotypes: 27 pathways were activated in AMD compared to controls, and 2 pathways were activated in controls compared to AMD. In AMD, we identified a graded activation of pathways related to wound response, complement cascade, and cell survival. Also, there was downregulation of two pathways responsible for apoptosis. Furthermore, significant activation of pro-mitotic pathways is consistent with dedifferentiation and cell proliferation events, which occur early in the pathogenesis of AMD. Significantly, we discovered new global pathway activation signatures of AMD involved in the cell-based inflammatory response: IL-2, STAT3, and ERK. The ultimate aim of our research is to achieve a better understanding of signaling pathways involved in AMD pathology, which will eventually lead to better treatments. PMID:25543336

  20. Is story-based blended learning a promising avenue for skin and sexual health education? Results from the PAEDIMED project.

    PubMed

    Apfelbacher, Christian J; Deimling, Erika; Wulfhorst, Britta; Adler, Frederic; Diepgen, Thomas L; Linder, Dennis; Blenk, Holger; Stosiek, Nikolaus; Reinmann, Gabi

    2010-03-01

    The PAEDIMED study group developed a learning and teaching scenario for school health education in the area of skin and sexual health in Italy, Romania and Germany, combining web-based and traditional learning ("blended learning"). A questionnaire-based needs assessment and context analysis were conducted, based on which an education scenario was designed. Particular emphasis was put on emotional and motivational aspects, using narrative components in the didactic concept. The design process occupied a central role in the project (design-based research). Evaluation was both formative and summative. Continuous feedback was obtained from relevant stakeholders. Following a prototypical implementation, the scenario was evaluated using questionnaires. The results revealed a high level of acceptance of the education scenario as well as an increase in students' knowledge concerning skin and sexual health. Evaluation also suggested that health education is highly influenced by cultural background and habits as well as diverse contextual and personal conditions. PMID:20169298

  1. Stakeholders’ perception on the organization of chronic care: a SWOT analysis to draft avenues for health care reforms

    PubMed Central

    2014-01-01

    Background Adequate care for individuals living with chronic illnesses calls for a healthcare system redesign, moving from acute, disease-centered to patient-centered models. The aim of this study was to identify Belgian stakeholders’ perceptions on the strengths, weaknesses, opportunities and threats of the healthcare system for people with chronic diseases in Belgium. Methods Four focus groups were held with stakeholders from the micro and meso level, in addition to two interviews with stakeholders who could not attend the focus group sessions. Data collection and the discussion were based on the Chronic Care model. Thematic analysis of the transcripts allowed for the identification of the strengths, weaknesses, opportunities and threats of the current health care system with focus on chronic care. Results Informants stressed the overall good quality of the acute health care system and the level of reimbursement of care as an important strength of the current system. In contrast, the lack of integration of care was identified as one of the biggest weaknesses of today’s health care system, along with the unclear definitions of the roles and functions of health professionals involved in care processes. Patient education to support self-management exists for patients with diabetes and/or terminal kidney failure but not for those living with other or multiple chronic conditions. The current overall fee-for-service system is a barrier to integrated care, as are the lack of incentives for integrated care. Attending multidisciplinary meetings, for example, is underfinanced to date. Finally, clinical information systems lack interoperability, which further impedes the information flow across settings and disciplines. Conclusion Our study’s methods allowed for the identification of problematic domains in the health system for people living with chronic conditions. These findings provided useful insights surrounding perceived priorities. This methodology may inspire other countries faced with the challenge of drafting reforms to tackle the issue of chronic care. PMID:24742204

  2. 75 FR 78978 - Record of Decision for the 158th Fighter Wing's Proposed Realignment of National Guard Avenue and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Department of the Air Force Record of Decision for the 158th Fighter Wing's Proposed Realignment of National...: On November 18, 2010, the United States Air Force signed the ROD for the 158th Fighter...

  3. Drell-Yan process as an avenue to test a noncommutative standard model at the Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    J, Selvaganapathy; Das, Prasanta Kumar; Konar, Partha

    2016-06-01

    We study the Drell-Yan process at the Large Hadron Collider in the presence of the noncommutative extension of the standard model. Using the Seiberg-Witten map, we calculate the production cross section to first order in the noncommutative parameter Θμ ν . Although this idea has been evolving for a long time, only a limited amount of phenomenological analysis has been completed, and this was mostly in the context of the linear collider. An outstanding feature from this nonminimal noncommutative standard model not only modifies the couplings over the SM production channel but also allows additional nonstandard vertices which can play a significant role. Hence, in the Drell-Yan process, as studied in the present analysis, one also needs to account for the gluon fusion process at the tree level. Some of the characteristic signatures, such as oscillatory azimuthal distributions, are an outcome of the momentum-dependent effective couplings. We explore the noncommutative scale ΛNC≥0.4 TeV , considering different machine energy ranging from 7 to 13 TeV.

  4. Stroke recovery and prevention barriers among young African-American men: Potential avenues to reduce health disparities

    PubMed Central

    Blixen, Carol; Perzynski, Adam; Cage, Jamie; Smyth, Kathleen; Moore, Shirley; Sila, Cathy; Pundik, Svetlana; Sajatovic, Martha

    2016-01-01

    Background African-Americans (AA) who experience a first time stroke are younger, and have double the stroke rate and more post-stroke complications than other Americans. Objective To assess perceived post-stroke care barriers among younger AA men and their care partners (CPs) in order to inform development of acceptable and effective improvements in post-stroke care for this high-risk group. Methods Ten community-dwelling AA stroke survivors and 7 of their care partners (CPs) participated in focus groups and advisory board meetings. Survivors had stroke or transient ischemic attack within one year and a Barthel ADL Index >60. In focus groups, using a semi-structured interview guide, survivors and CPs identified self-perceived barriers and facilitators to post-stroke care. Thematic analysis of session transcripts and the constant comparative method were used to generate themes. Results Survivor age ranged from 34 to 64. Mean Barthel was 95.5. CPs, all AA women, ranged in age from 49–61. CPs were 5 wives, a fianceé and a niece. Participants cited multiple personal, social, and societal stroke recovery challenges. While hypertension and smoking risks were acknowledged, stress, depression, PTSD, anger/frustration, personal identity change, and difficulty communicating unique needs as AA men were much more frequently noted. Facilitators included family support, stress reduction and dietary changes. Conclusions Younger AA men and their CPs perceive multiple post-stroke care barriers. Biological risk reduction education may not capture all salient aspects of health management for AA stroke survivors. Leveraging family and community strengths, addressing psychological health, and directly engaging patients with healthcare teams may improve care management. PMID:25341388

  5. Estradiol-15 alpha-hydroxylation: a new avenue of estrogen metabolism in peri-implantation pig blastocysts.

    PubMed

    Chakraborty, C; Davis, D L; Dey, S K

    1990-02-01

    Pig blastocysts have the capacity to convert estradiol into catechol estrogens. Our present study shows that they also have the capacity to hydroxylate estradiol in cycloaliphatic C-atom 15, and this aliphatic hydroxylation reaction is more predominate than the aromatic hydroxylations. The conversion of [4-14C]estradiol to [4-14C]15 alpha-hydroxyestradiol by mitochondrial-rich/microsomal fractions was examined by isolation of this product using reversed phase high-performance liquid chromatography (HPLC) attached to a radiometric flow detector, and its identification by gas chromatography-mass spectrometry. The enzyme kinetics for estrogen 15 alpha-hydroxylase were performed in the pig blastocyst obtained on Day 13 of pregnancy (Day 0 = first acceptance of the male). The enzyme follows classical Michaelis-Menten kinetics. The apparent Kms for estradiol were 2.47 and 1.85 microM, and the apparent Vmaxs were 0.25 and 0.197 nmol/mg/min in the mitochondrial-rich and microsomal fractions, respectively. The enzyme activity was inhibited by different steroidal compounds and non-steroidal estrogens, as well as by CO, SKF-525A, piperonyl butoxide and antibody to cytochrome P450 reductase. Ontogenesis of the blastocyst's estrogen 15 alpha-hydroxylase follows a similar pattern to that of estrogen-2/4-hydroxylase. Thus, highest activity was observed on Days 12 and 13 and lowest was on Day 15 of pregnancy. Furthermore, the enzyme is abundant primarily in the extraembryonic tissues rather than in the embryo proper. The abundance of the enzyme in the extraembryonic tissues, and its surge at a critical time of pregnancy recognition and just prior to implantation suggest that 15 alpha-hydroxylated estradiol could be involved in these processes. PMID:2155354

  6. Social Media as Avenue for Personal Learning for Educators: Personal Learning Networks Encourage Application of Knowledge and Skills

    ERIC Educational Resources Information Center

    Eller, Linda S.

    2012-01-01

    Social media sites furnish an online space for a community of practice to create relationships and trust, collaboration and connections, and a personal learning environment. Social networking sites, both public and private, have common elements: member profiles, groups, discussions, and forums. A community of practice brings participants together…

  7. Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design1

    PubMed Central

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P.; Thorn, Katherine J.; Christianson, David W.

    2011-01-01

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design, and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of α,α-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2- methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional α-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase. PMID:21728378

  8. Confirmatory/release survey of the property at 71 Pearce Avenue (Former EAD Building) in Tonawanda, New York

    SciTech Connect

    Salame-Alfie, A.; Alibozek, R.

    1995-12-31

    EAD Metallurgical, Inc., operated a facility in Tonawanda, New York, in which it utilized Americium 241 (Am-241) for the production of foil sources for use in smoke detectors. EAD was in operation between 1977 and 1983. By 1983, the company started losing money, and decided to relocate to Mexico. Before closing down its Tonawanda operation, however, it was required by the New York State Department of Labor (DOL) to decontaminate its facility to limits specified by DOL. No records of discharges to the sewer system were kept during this decontamination effort. Unsuccessful decontamination efforts by several EAD employees and contractors left the building contaminated, in particular the concrete floors and walls. To determine the scope of work for the decontamination project, staff from the New York State Departments of Health (DOH) and Environmental Conservation (DEC) conducted a Characterization Survey of the facility in 1993. This survey identified contamination levels of Am-241 in excess of release limits throughout the building, in the soil outside the facility, in pipes for sewage and interior drainage, and in an 8 x 8 x 11 foot sump pit in the building. DOH issued a request for proposals in early 1994 for the decontamination and subsequent decommissioning of the former EAD building, and NES/IES Inc. (NES) was awarded the contract to perform the remediation. DOH`s assignment was to provide an on-site presence to insure the completion of all agreed upon tasks, according to the terms of the contract and work plans submitted by NES. Additionally, the DOH staff acted as a liaison between NES, DOH, DEC and DOL central offices to review, comment and approve all changes or modifications to NES`s approach to the decontamination efforts. The assigned staff was also responsible for conducting confirmatory sampling and surveys of all areas deemed releasable to DOL and DEC criteria by NES.

  9. Providing an Avenue for Individual Enhancement: The Challenge for Vocational-Technical Education and Training in Nigeria.

    ERIC Educational Resources Information Center

    Khaleel, Ibrahim Adamu

    Nigeria's social and economic conditions at and after independence necessitated changes in educational and employment policy. At independence, in 1960, unification and economic development were necessary to galvanize the country's direction. Control and domination of the economy by foreigners deprived the country of the development of an…

  10. Radiological assessment report for the Lansdowne property, 105-107 East Stratford Avenue, Lansdowne, Pennsylvania, October-December 1984

    SciTech Connect

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Flynn, K.F.

    1985-09-01

    Areas with elevated levels of radioactivity were found throughout both residences, as well as on the surrounding property. Contamination was also found in the garage behind the 105 East structure. The 105 East residence had substantially more contamination than the 107 East residence, as was expected. The chimneys, particularly the rear chimney, from the 105 East residence had extensive contamination, indicating that contaminated materials may have been burned at the site. The high background radiation emanating from this residence made it difficult to establish the relatively lower levels of contamination in the 107 East residence. The property surrounding the 105 East residence was found to have substantial contamination scattered throughout, with the highest level occurring in the backyard. The soil surface contamination seemed to drop markedly (but not entirely) at the property lines. The property surrounding 107 East was found to be less contaminated, although the background radiation emanating from the adjoining area made it difficult to establish the degree of surface or near-surface contamination from surface surveys. Subsurface investigation of the soil surrounding the structure indicated that radium contamination was widespread and extended to a depth of eight feet at some locations. There was evidence that some of this contamination extended onto adjoining properties and may have been transported off the site via subsurface migration. Additionally, analysis of samples from access points in the residence sewer system effluent established that the system was contaminated. 3 refs., 26 figs., 13 tabs.

  11. Mitochondrial cytochrome c oxidase subunit 1 (cox1) gene sequence of Spirocerca lupi (Nematoda, Spirurida): avenues for potential implications.

    PubMed

    Traversa, Donato; Costanzo, Francesca; Iorio, Raffaella; Aroch, Itamar; Lavy, Eran

    2007-05-31

    Canine spirocercosis is a life-threatening parasitosis caused by Spirocerca lupi (Nematoda, Spirurida) that is presently emerging in several countries. This study characterised an informative region within the mitochondrial (mtDNA) gene encoding for the cytochrome c oxidase subunit 1 (cox1) of S. lupi by Polymerase Chain Reaction (PCR)-coupled sequencing. Specimens from five different countries in Europe, Asia and Africa were examined and two different sequence variants of cox1 (i.e. haplotypes) were determined, displaying nucleotidic variation at 6 of 689 positions. All of these positions were invariable among all the parasite individuals from Europe (haplotype 1) and among the African and Asian individuals (haplotype 2), but differed between Europe and Asia/Africa. The S. lupi cox1 sequences were consistent with those of other common Spirurida previously reported at both nucleotidic and phylogenetic levels. This study provides molecular information essential for identification of the nematode, irrespective of its life cycle stage. Crucial implications for the specific molecular diagnosis of clinical spirocercosis and investigation of the evolution, population genetics, ecology and epidemiology of S. lupi are discussed. PMID:17428608

  12. Biosynthesis of metallic nanoparticles using plant derivatives and their new avenues in pharmacological applications - An updated report.

    PubMed

    Kuppusamy, Palaniselvam; Yusoff, Mashitah M; Maniam, Gaanty Pragas; Govindan, Natanamurugaraj

    2016-07-01

    The field of nanotechnology mainly encompasses with biology, physics, chemistry and material sciences and it develops novel therapeutic nanosized materials for biomedical and pharmaceutical applications. The biological syntheses of nanoparticles are being carried out by different macro-microscopic organisms such as plant, bacteria, fungi, seaweeds and microalgae. The biosynthesized nanomaterials have been effectively controlling the various endemic diseases with less adverse effect. Plant contains abundant natural compounds such as alkaloids, flavonoids, saponins, steroids, tannins and other nutritional compounds. These natural products are derived from various parts of plant such as leaves, stems, roots shoots, flowers, barks, and seeds. Recently, many studies have proved that the plant extracts act as a potential precursor for the synthesis of nanomaterial in non-hazardous ways. Since the plant extract contains various secondary metabolites, it acts as reducing and stabilizing agents for the bioreduction reaction to synthesized novel metallic nanoparticles. The non-biological methods (chemical and physical) are used in the synthesis of nanoparticles, which has a serious hazardous and high toxicity for living organisms. In addition, the biological synthesis of metallic nanoparticles is inexpensive, single step and eco-friendly methods. The plants are used successfully in the synthesis of various greener nanoparticles such as cobalt, copper, silver, gold, palladium, platinum, zinc oxide and magnetite. Also, the plant mediated nanoparticles are potential remedy for various diseases such as malaria, cancer, HIV, hepatitis and other acute diseases. PMID:27330378

  13. 77 FR 74504 - Proposed Low-Effect Habitat Conservation Plan for the State-Route 99/Cartmill Avenue Interchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... fairy shrimp and the San Joaquin kit fox. The applicant would implement a conservation strategy program... listed species will be included as covered species in the applicant's proposed HCP: San Joaquin kit fox... the Endangered San Joaquin Kit Fox Prior to or During Ground Disturbance.'' Other avoidance...

  14. ASSESSING UST CORRECTIVE ACTION TECHNOLOGIES: LESSONS LEARNED ABOUT IN SITU AIR SPARGING AT THE DENISON AVENUE SITE - CLEVELAND, OH

    EPA Science Inventory

    In situ air sparging (IAS) has been proposed and installed at an increasing number of sites to address contamination in both the saturated and unsaturated zones. Because of the lack of experimental and substantive performance data, however, the actual performance and effectivene...

  15. 7 CFR 29.8001 - Designation of tobacco markets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., 1936. 1 FR 1416. (f) Kentucky Burley—Type 31 Bowling Green, KyCynthiana, Ky. Horse Cave, Ky. Mt... July 5, 1996 61 FR 27997. (mmm) Kentucky Burley Horse Cave-Glasgow-Greensburg, KY July 15, 1996 61...

  16. 7 CFR 29.8001 - Designation of tobacco markets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., 1936. 1 FR 1416. (f) Kentucky Burley—Type 31 Bowling Green, KyCynthiana, Ky. Horse Cave, Ky. Mt... July 5, 1996 61 FR 27997. (mmm) Kentucky Burley Horse Cave-Glasgow-Greensburg, KY July 15, 1996 61...

  17. 7 CFR 29.8001 - Designation of tobacco markets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., 1936. 1 FR 1416. (f) Kentucky Burley—Type 31 Bowling Green, KyCynthiana, Ky. Horse Cave, Ky. Mt... July 5, 1996 61 FR 27997. (mmm) Kentucky Burley Horse Cave-Glasgow-Greensburg, KY July 15, 1996 61...

  18. 7 CFR 29.8001 - Designation of tobacco markets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., 1936. 1 FR 1416. (f) Kentucky Burley—Type 31 Bowling Green, KyCynthiana, Ky. Horse Cave, Ky. Mt... July 5, 1996 61 FR 27997. (mmm) Kentucky Burley Horse Cave-Glasgow-Greensburg, KY July 15, 1996 61...

  19. 7 CFR 29.8001 - Designation of tobacco markets.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., 1936. 1 FR 1416. (f) Kentucky Burley—Type 31 Bowling Green, KyCynthiana, Ky. Horse Cave, Ky. Mt... July 5, 1996 61 FR 27997. (mmm) Kentucky Burley Horse Cave-Glasgow-Greensburg, KY July 15, 1996 61...

  20. 77 FR 5507 - Turlock Irrigation District, Modesto Irrigation District; Notice of Proposed Restricted Service...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Me-Wuk Indians, North Fork Mono Tribe, Southern Sierra Miwuk Nation, Chicken Ranch Rancheria of Me..., Chicken Ranch Rancheria of Me-Wuk Indians, P.O. Box 1159, Jamestown, CA 95327. Silvia Burley...

  1. 7 CFR 29.401 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... or burley tobacco. (n) Pesticide. Any substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest, and any substance or mixture of substances intended for use...

  2. 7 CFR 29.401 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... or burley tobacco. (n) Pesticide. Any substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest, and any substance or mixture of substances intended for use...

  3. Gender Differences in Expressed Interests in Engineering-Related Fields ACT 30-Year Data Analysis Identified Trends and Suggested Avenues to Reverse Trends

    ERIC Educational Resources Information Center

    Iskander, E. Tiffany; Gore, Paul A., Jr.; Furse, Cynthia; Bergerson, Amy

    2013-01-01

    Historically, women have been underrepresented in the Science, Technology, Engineering, and Math (STEM) fields both as college majors and in the professional community. This disturbing trend, observed in many countries, is more serious and evident in American universities and is reflected in the U.S. workforce statistics. In this article, we…

  4. New avenue in the treatment of temporal lobe epilepsy by classical anti-epileptics: A hypothetical establishment of executioner Caspase 3 inactivation by molecular modeling.

    PubMed

    Aanandhi, M Vijey; Bhattacherjee, Debojit; Ray, Anirban; George, P Samuel Gideon

    2015-01-01

    Patients with temporal lobe epilepsy (TLE) are prescribed first-line antiepileptic drugs and surgery to the management of this disorder. Unfortunately, the surgical treatment has been shown to be beneficial for the selected patients but fails to provide a seizure-free outcome in 20-30% of TLE patients. In our present study, we investigate the possibilities of marketed antiepileptic drugs in a different manner to improve the present situation in TLE. Molecular docking simulation study and various open source computational tools were used to perform the study. AutoDock 4.2 MGL tools, Pymol visualize tools, Patch dock server, and Swarm Dock servers (protein-protein docking) were used to perform the molecular modeling. FTsite and computed atlas of surface topography of protein open source server were used to understand the pocket and ligand binding information respectively. Toxtree application was used to determine the toxicity profile of the drug by Cramers rule. The obtained molecular docking models (Caspase 3, Procaspase 8, and Fas-associated death domain [FADD]) with selected compounds (Clonazepam, Clobazepam, and Retigabine) showed promising trio blocking event of FADD, Caspase 3, and Procaspase 8 (-6.66 kcal, -8.1 kcal, 6.46 kcal) by Clonazepam respectively. Protein-protein interaction study (Swarm Dock, Patch Dock server) indicated promising results that helped to establish our hypothesis. Toxtree showed a quantitative structure toxicity relationship report that helps to clarify the toxicity of the selected compounds. Clonazepam showed a trio inhibition property that may lead to develop a new era of the new generation benzodiazepine prototype drugs in the future. Filtered compounds will further process for higher in vitro, in vivo models for better understanding of the mechanism. PMID:25878976

  5. To designate the facility of the United States Postal Service located at 16300 Broadway Avenue in Maple Heights, Ohio, as the "Daniel Kondas Post Office".

    THOMAS, 112th Congress

    Rep. Fudge, Marcia L. [D-OH-11

    2011-05-02

    05/13/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Predicting the Weather and Building the Boats: Full Service Schools as One Avenue to School Success for All of America's Children

    ERIC Educational Resources Information Center

    Kronick, Robert F.

    2003-01-01

    This article describes the evolution of full service schools. Full service schools stress prevention, collaboration and systems change. Prevention is geared toward corrections, mental health and welfare, all topics of keen interest to people working in and studying criminal justice. By providing mental health services at the school for both…

  7. To designate the facility of the United States Postal Service located at 1449 West Avenue in Bronx, New York, as the "Private Isaac T. Cortes Post Office".

    THOMAS, 111th Congress

    Rep. Crowley, Joseph [D-NY-7

    2010-09-23

    12/22/2010 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  8. Multiphoton ionization of N2 by the third harmonic of a Nd:YAG laser - A new avenue for air diagnostics

    NASA Technical Reports Server (NTRS)

    Laufer, Gabriel; Krauss, Roland H.; Grinstead, Jay H.

    1991-01-01

    Laser-induced N2 ionization is accomplished using a commercially available Nd:YAG laser, and confirmed by means of ion-collection and spectral measurements. Neutral N2 is excited by six photons of the third harmonic frequency, or 355 nm, and is transformed to an ionized state. The radiation at 355 nm is separated from the fundamental and frequency-doubled Nd:YAG radiation to guarantee monochromatic incident radiation. Intense lines near 391.4 nm are found in the initial laser polarization and for a 90-degree rotation of polarization. The radiation at 391.4 nm is associated with an incoherent laser-induced flourescence process related to an ionized-state transition, and increases quadratically with laser power. A 45-mJ laser pulse focused to a diameter of 17 microns can produce an ion concentration of 3.25 x 10 to the 13th ions/cu cm. The large ion concentration and robust fluorescence signal make this technique an efficient method for time-of-flight velocimetry and in-flight testing.

  9. Solar space heating system at the Seeley G. Mudd Education Building, Pacific School of Religion, 1798 Scenic Avenue, Berkeley California 94708. Final report

    SciTech Connect

    Not Available

    1981-12-01

    Large areas of south facing glass allow winter sunlight to penetrate the building, while overhangs provide summer shading. High ceilings allow deep penetration of this light for space heating and natural lighting. Massive construction stores solar radiation for evening warmth and provides a buffer from extreme temperature fluctuations. Natural ventilation will provide cooling. The system consists of 720 square feet of roof-mounted, liquid, flat plate solar collectors and three 350 gallon fiberglass storage tanks. The acceptance and performance tests are discussed. Also discusseed are: collector selection, construction contract, costs, and economics.

  10. New avenue in the treatment of temporal lobe epilepsy by classical anti-epileptics: A hypothetical establishment of executioner Caspase 3 inactivation by molecular modeling

    PubMed Central

    Aanandhi, M. Vijey; Bhattacherjee, Debojit; Ray, Anirban; George, P. Samuel Gideon

    2015-01-01

    Patients with temporal lobe epilepsy (TLE) are prescribed first-line antiepileptic drugs and surgery to the management of this disorder. Unfortunately, the surgical treatment has been shown to be beneficial for the selected patients but fails to provide a seizure-free outcome in 20–30% of TLE patients. In our present study, we investigate the possibilities of marketed antiepileptic drugs in a different manner to improve the present situation in TLE. Molecular docking simulation study and various open source computational tools were used to perform the study. AutoDock 4.2 MGL tools, Pymol visualize tools, Patch dock server, and Swarm Dock servers (protein-protein docking) were used to perform the molecular modeling. FTsite and computed atlas of surface topography of protein open source server were used to understand the pocket and ligand binding information respectively. Toxtree application was used to determine the toxicity profile of the drug by Cramers rule. The obtained molecular docking models (Caspase 3, Procaspase 8, and Fas-associated death domain [FADD]) with selected compounds (Clonazepam, Clobazepam, and Retigabine) showed promising trio blocking event of FADD, Caspase 3, and Procaspase 8 (−6.66 kcal, −8.1 kcal, 6.46 kcal) by Clonazepam respectively. Protein-protein interaction study (Swarm Dock, Patch Dock server) indicated promising results that helped to establish our hypothesis. Toxtree showed a quantitative structure toxicity relationship report that helps to clarify the toxicity of the selected compounds. Clonazepam showed a trio inhibition property that may lead to develop a new era of the new generation benzodiazepine prototype drugs in the future. Filtered compounds will further process for higher in vitro, in vivo models for better understanding of the mechanism. PMID:25878976

  11. Determining the Most Important Physiological and Agronomic Traits Contributing to Maize Grain Yield through Machine Learning Algorithms: A New Avenue in Intelligent Agriculture

    PubMed Central

    Shekoofa, Avat; Emam, Yahya; Shekoufa, Navid; Ebrahimi, Mansour; Ebrahimie, Esmaeil

    2014-01-01

    Prediction is an attempt to accurately forecast the outcome of a specific situation while using input information obtained from a set of variables that potentially describe the situation. They can be used to project physiological and agronomic processes; regarding this fact, agronomic traits such as yield can be affected by a large number of variables. In this study, we analyzed a large number of physiological and agronomic traits by screening, clustering, and decision tree models to select the most relevant factors for the prospect of accurately increasing maize grain yield. Decision tree models (with nearly the same performance evaluation) were the most useful tools in understanding the underlying relationships in physiological and agronomic features for selecting the most important and relevant traits (sowing date-location, kernel number per ear, maximum water content, kernel weight, and season duration) corresponding to the maize grain yield. In particular, decision tree generated by C&RT algorithm was the best model for yield prediction based on physiological and agronomical traits which can be extensively employed in future breeding programs. No significant differences in the decision tree models were found when feature selection filtering on data were used, but positive feature selection effect observed in clustering models. Finally, the results showed that the proposed model techniques are useful tools for crop physiologists to search through large datasets seeking patterns for the physiological and agronomic factors, and may assist the selection of the most important traits for the individual site and field. In particular, decision tree models are method of choice with the capability of illustrating different pathways of yield increase in breeding programs, governed by their hierarchy structure of feature ranking as well as pattern discovery via various combinations of features. PMID:24830330

  12. Delirium in Hospitalized Patients: Implications of Current Evidence on Clinical Practice and Future Avenues for Research—A Systematic Evidence Review

    PubMed Central

    Khan, Babar A.; Zawahiri, Mohammed; Campbell, Noll L.; Fox, George C.; Weinstein, Eric J.; Nazir, Arif; Farber, Mark O.; Buckley, John D.; MacLullich, Alasdair; (UK), MRCP; Boustani, Malaz A.

    2013-01-01

    BACKGROUND Despite the significant burden of delirium among hospitalized adults, critical appraisal of systematic data on delirium diagnosis, pathophysiology, treatment, prevention, and outcomes is lacking. PURPOSE To provide evidence-based recommendations for delirium care to practitioners, and identify gaps in delirium research. DATA SOURCES Medline, PubMed, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) information systems fromJanuary 1966 to April 2011. STUDY SELECTION All published systematic evidence reviews (SERs) on delirium were evaluated. DATA EXTRACTION Three reviewers independently extracted the data regarding delirium risk factors, diagnosis, prevention, treatment, and outcomes, and critically appraised each SER as good, fair, or poor using the United States Preventive Services Task Force criteria. DATA SYNTHESIS Twenty-two SERs graded as good or fair provided the data. Age, cognitive impairment, depression, anticholinergic drugs, and lorazepam use were associated with an increased risk for developing delirium. The Confusion Assessment Method (CAM) is reliable for delirium diagnosis outside of the intensive care unit. Multicomponent nonpharmacological interventions are effective in reducing delirium incidence in elderly medical patients. Low-dose haloperidol has similar efficacy as atypical antipsychotics for treating delirium. Delirium is associated with poor outcomes independent of age, severity of illness, or dementia. CONCLUSION Delirium is an acute, preventable medical condition with short- and long-term negative effects on a patient’s cognitive and functional states. PMID:22684893

  13. Avenues of Entry into the World of Western Art Music: Exposing Students to Western Art Music Informally Is One Way to Promote Appreciation for This Music

    ERIC Educational Resources Information Center

    Szabo, Moira

    2005-01-01

    Throughout the author's teaching career of the last thirty years, he has thought a great deal about how to prepare children for meaningful encounters with Western art music, a type of music that is not normally a part of their listening environments. (Many young people consider it music of the grey-haired generation.) The Western art music he was…

  14. Assessing UST corrective action technologies: Lessons learned about in situ air sparging at the Denison Avenue Site, Cleveland, Ohio. Project report

    SciTech Connect

    Clark, T.R.; Chaudet, R.E.; Johnson, R.L.

    1994-12-01

    In situ air sparging (IAS) has been used at an increasing number of sites to address groundwater contamination. Because of the lack of substantive performance data, however, the actual effectiveness of the system is not known. The EPA Office of Research and Development Risk reduction Engineering Laboratory (ORD RREL) with the EPA Region 5 Office of Underground Storage Tanks, the Ohio State Fire Marshal, and BP Exploration & Oil, Inc. (BP) participated in a field evaluation of an IAS system at a petroleum leaking UST site in Cleveland, Ohio. The purpose of the study was to provide performance data that will be independently evaluated by EPA to better understand IAS effectiveness. The report presents the site and monitoring data provided by BP over a 2-year period. The chemical data indicated an overall decrease of BTEX concentrations in groundwater to nondetectable levels shortly after startup of the IAS system. Variability in the chemical and process data also precludes making any definitive link between the decrease in contaminant concentrations and IAS performance at this site.

  15. In-flight verification of avalanche photodiodes: avenue to a low-cost solution to measure suprathermal particles for future missions

    NASA Astrophysics Data System (ADS)

    Ogasawara, K.; Bonnell, J. W.; Christian, E. R.; Desai, M. I.; Grubbs, G. A., II; Jahn, J. M.; Livi, S. A.; Kanekal, S. G.; Llera, K.; McComas, D. J.; Michell, R.; Samara, M.; Vines, S. K.

    2014-12-01

    Flight operation results and plans of Avalanche Photodiodes (APDs) to measure suprathermal particles (a ~few keV up to ~100s of keV) are summarized in this presentation. Ions and electrons in this energy range play crucial roles in many fundamental processes of space plasmas including particle heating and acceleration, providing source material for the energetic particles accelerated near the Sun, the heliosphere, and in geospace. Characterizing these populations poses serious technical challenges because this energy region lies between the two most commonly used particle detection techniques, i.e., that used by thermal or plasma instruments and by Solid-State Detector (SSD)-based energetic particle telescopes, which are limited by typical SSD threshold energies of >10s keV. Our previous work has already demonstrated that a new type of low-noise, low-threshold Avalanche Photo-Diode (APD) has an intrinsic noise level of 0.9 keV, and can therefore enable high-energy resolution measurements of suprathermal electrons and ions. In addition, APDs provide suitable solutions for space plasma detectors in low-cost missions/platform because of their light-weight, small-size, power-saving features. This study presents two low-cost missions (a sounding rocket and a CubeSat) that implement APDs as particle detectors: (1) The Medium-energy Electron SPectrometer (MESP) sensor aboard a sounding rocket was launched from Poker Flat Research Range on 3 March 2014 as a part of Ground-to-Rocket Electrodynamics-Electrons Correlative Experiment (GREECE) mission. MESP successfully measured the precipitating electrons from 2 to 200 keV in 100-ms time resolution by using 2 APDs and 1 SSD. We show the overall results and the comparison with an MCP-based instrument results. (2) The Miniaturized Electron and pRoton Telescope (MERiT) on the Compact Radiation bElt Explorer (CeREs) to study charged particle dynamics in the Earth's radiation belts. CeREs will be flown as part of a 3U CubeSat in a high-inclination low-Earth orbit in 2015. MERiT is designed to measure suprathermal to relativistic electrons from ~5 keV up to10 MeV, and 4 APDs will be applied to cover the lower portion of the energy range. Along with the calibration efforts, we will present predicted in-orbit performances of these APD detectors in the CeREs mission.

  16. EGF-R small inhibitors and anti-EGF-R antibodies: advantages and limits of a new avenue in anticancer therapy.

    PubMed

    Caraglia, Michele; Marra, Monica; Meo, Giuseppina; Addeo, Santolo R; Tagliaferri, Pierosandro; Budillon, Alfredo

    2006-06-01

    Cellular receptors for the Epidermal Growth Factor (EGF-R) are members of the ErbB receptor family and are considered important targets for the experimental treatment of human cancer. Monoclonal antibodies as well as small tyrosine kinase inhibitors (TKIs) have been developed and have undergone extensive evaluation in preclinical and clinical studies based on the general idea that EGF-R plays a critical role on the growth and survival of human tumors. This assumption has been derived by the successful development of BCR/ABL tyrosine kinase inhibitors in human chronic myeloid leukemia as well as on the activity of therapy with monoclonal antibodies (mAb) in breast cancer and lymphoproliferative diseases. It is now becoming clear that factors regulating sensitivity to kinase inhibitors may differ from monoclonal antibodies and that the molecules targeted by interfering drugs must be prioritaire for growth and survival of those specific tumors in order to achieve valuable results. In this article, we will describe the signal transduction pathways regulated by EGF-R and the principal pharmacological and biotechnological agents directed against EGF-R. We will discuss the significance of targeting the EGF-R driven survival pathways and the compensatory intracellular survival mechanisms that counteract the specific EGF-R inhibition and are the cause of the poor clinical results derived from study based on the use of these agents. We will describe new multipotent TKIs that target also other members of ErbB family (i.e. ErbB2) blocking one of the compensatory mechanism that can be triggered in cancer cells. Moreover, we will report new patent on bispecific mAbs that bind EGF-R and immune effectors in order to increase the immunological function of this agent that could be the basis of the different clinical results achieved with the use of TKI and mAbs. Finally, we will propose a pharmacological model able to make cancer cells dependent on EGF-R for their survival and proliferation and we will discuss the relevance of patenting also new therapeutical strategies and not only the simple drug. PMID:18221038

  17. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy.

    PubMed Central

    Daughton, Christian G

    2003-01-01

    Since the 1980s, the occurrence of pharmaceuticals and personal care products (PPCPs) as trace environmental pollutants, originating primarily from consumer use and actions rather than manufacturer effluents, continues to become more firmly established. Although PPCPs typically have been identified in surface and ground waters, some are also undoubtedly associated with solid phases such as suspended particulates, sediments, and sewage sludges, despite their relatively high affinity for water. Often amenable to degradation, their continual introduction to waste-receiving waters results from their widespread, continuous, combined use by individuals and domestic animals, giving PPCPs a "pseudo-persistence" in the environment. Little is known about the environmental or human health hazards that might be posed by chronic, subtherapeutic levels of these bioactive substances or their transformation products. The continually growing, worldwide importance of freshwater resources, however, underscores the need for ensuring that any aggregate or cumulative impacts on (or from) water supplies are minimized. Despite the paucity of effects data from long-term, simultaneous exposure at low doses to multiple xenobiotics (particularly non-target-organism exposure to PPCPs), a wide range of proactive actions could be implemented to reduce or minimize the introduction of PPCPs to the environment. Most of these actions fall under what could be envisioned as a holistic stewardship program--overseen by the health care industry and consumers alike. Significantly, such a stewardship program would benefit not just the environment; additional, collateral benefits could automatically accrue, including reducing consumers' medication expenses and improving patient health and consumer safety. In this article, the first of a two-part mini-monograph describing the "green pharmacy," I focus initially on the background behind the imperative for an ecologically oriented stewardship program for PPCPs. I then present a broad spectrum of possible source control/reduction actions, controlled largely by the health care industry, that could minimize the disposition of PPCPs to the environment. This two-part mini-monograph attempts to capture cohesively for the first time the wide spectrum of actions available for minimizing the release of PPCPs to the environment. A major objective is to generate an active dialog or debate across the many disciplines that must become actively involved to design and implement a successful approach to life-cycle stewardship of PPCPs. PMID:12727606

  18. To designate the United States courthouse located at 222 West 7th Avenue in Anchorage, Alaska, as the "James M. Fitzgerald United States Courthouse".

    THOMAS, 112th Congress

    Rep. Young, Don [R-AK-At Large

    2011-10-13

    10/14/2011 Referred to the Subcommittee on Economic Development, Public Buildings and Emergency Management. (All Actions) Notes: For further action, see S.1710, which became Public Law 112-101 on 3/14/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  19. Quantitative Analysis of Therapeutic Drugs in Dried Blood Spot Samples by Paper Spray Mass Spectrometry: An Avenue to Therapeutic Drug Monitoring

    NASA Astrophysics Data System (ADS)

    Manicke, Nicholas Edward; Abu-Rabie, Paul; Spooner, Neil; Ouyang, Zheng; Cooks, R. Graham

    2011-09-01

    A method is presented for the direct quantitative analysis of therapeutic drugs from dried blood spot samples by mass spectrometry. The method, paper spray mass spectrometry, generates gas phase ions directly from the blood card paper used to store dried blood samples without the need for complex sample preparation and separation; the entire time for preparation and analysis of blood samples is around 30 s. Limits of detection were investigated for a chemically diverse set of some 15 therapeutic drugs; hydrophobic and weakly basic drugs, such as sunitinib, citalopram, and verapamil, were found to be routinely detectable at approximately 1 ng/mL. Samples were prepared by addition of the drug to whole blood. Drug concentrations were measured quantitatively over several orders of magnitude, with accuracies within 10% of the expected value and relative standard deviation (RSD) of around 10% by prespotting an internal standard solution onto the paper prior to application of the blood sample. We have demonstrated that paper spray mass spectrometry can be used to quantitatively measure drug concentrations over the entire therapeutic range for a wide variety of drugs. The high quality analytical data obtained indicate that the technique may be a viable option for therapeutic drug monitoring.

  20. Colonie Interim Storage Site environmental report for calendar year 1992, 1130 Central Avenue, Colonie, New York. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Colonie Interim Storage Site (CISS) and provides the results for 1992. The site is located in eastern New York State, approximately 6.4 km (4.0 mi) northwest of downtown Albany. From 1958 to 1984, National Lead (NL) Industries used the facility to manufacture various components from depleted and enriched uranium natural thorium. Environmental monitoring of CISS began in 1984 when Congress added, the site to the US Department of Energy`s (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP is a program established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. The environmental surveillance program at CISS includes sampling networks for external gamma radiation exposure and for thorium-232 and total uranium concentrations in surface water, sediment, and groundwater. Several chemical parameters are also measured in groundwater, including total metals, volatile organics, and water quality parameters. This surveillance program assists in fulfilling the DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses. Results are compared with applicable Environmental Protection Agency (EPA) and New York State Department of Environmental Conservation (NYSDEC) standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements.

  1. The extraction of neural information from the surface EMG for the control of upper-limb prostheses: emerging avenues and challenges.

    PubMed

    Farina, Dario; Jiang, Ning; Rehbaum, Hubertus; Holobar, Aleš; Graimann, Bernhard; Dietl, Hans; Aszmann, Oskar C

    2014-07-01

    Despite not recording directly from neural cells, the surface electromyogram (EMG) signal contains information on the neural drive to muscles, i.e., the spike trains of motor neurons. Using this property, myoelectric control consists of the recording of EMG signals for extracting control signals to command external devices, such as hand prostheses. In commercial control systems, the intensity of muscle activity is extracted from the EMG and used for single degrees of freedom activation (direct control). Over the past 60 years, academic research has progressed to more sophisticated approaches but, surprisingly, none of these academic achievements has been implemented in commercial systems so far. We provide an overview of both commercial and academic myoelectric control systems and we analyze their performance with respect to the characteristics of the ideal myocontroller. Classic and relatively novel academic methods are described, including techniques for simultaneous and proportional control of multiple degrees of freedom and the use of individual motor neuron spike trains for direct control. The conclusion is that the gap between industry and academia is due to the relatively small functional improvement in daily situations that academic systems offer, despite the promising laboratory results, at the expense of a substantial reduction in robustness. None of the systems so far proposed in the literature fulfills all the important criteria needed for widespread acceptance by the patients, i.e. intuitive, closed-loop, adaptive, and robust real-time ( 200 ms delay) control, minimal number of recording electrodes with low sensitivity to repositioning, minimal training, limited complexity and low consumption. Nonetheless, in recent years, important efforts have been invested in matching these criteria, with relevant steps forwards. PMID:24760934

  2. Student Voice or Empowerment? Examining the Role of School-Based Youth-Adult Partnerships as an Avenue toward Focusing on Social Justice

    ERIC Educational Resources Information Center

    Mitra, Dana L.

    2006-01-01

    Drawing on the parallel literature on increasing student voice in the field of education and on building youth-adult partnerships in the youth development field, this article examines the place of young people in efforts to increase social justice in school settings. Through an examination of thirteen youth-adult partnership initiatives, it…

  3. Challenges in managing amniotic fluid embolism: an up-to-date perspective on diagnostic testing with focus on novel biomarkers and avenues for future research.

    PubMed

    Stawicki, Stanislaw P; Papadimos, Thomas J

    2014-01-01

    Amniotic fluid embolism (AFE) continues to pose a formidable clinical challenge with its high rate of morbidity and mortality. A novel biomarker that acts as an early warning system for the clinician would be a welcomed addition to our medical armamentarium. Here we review the state of diagnosing AFE with our current methods of evaluation and testing along with recently discovered potential biomarkers that may be clinically efficacious. Additionally we explore the future of proteomics, lipidomics, and transcriptomics as tools to identify potential novel signaling pathways and biomarkers. PMID:24804725

  4. Cost-effective bifacial dye-sensitized solar cells with transparent iron selenide counter electrodes. An avenue of enhancing rear-side electricity generation capability

    NASA Astrophysics Data System (ADS)

    Liu, Juan; Tang, Qunwei; He, Benlin; Yu, Liangmin

    2015-02-01

    Alloy materials have established themselves as alternative electrocatalysts for electrochemical devices because of their cost-effectiveness, high conductivity, good electrocatalytic activity, and reasonable stability. Aiming at reducing fabrication cost without sacrificing power conversion efficiency of dye-sensitized solar cells (DSSCs), we report the feasibility of designing transparent and cost-effective Fe-Se alloy counter electrodes for bifacial DSSCs. Due to the rapid charge transfer ability and electrocatalytic activity, maximum front and rear efficiencies of 7.64% and 4.95% are measured for the DSSC with FeSe alloy electrode in comparison with 6.97% and 3.56% from Pt-based solar cell. The impressive results along with simple synthesis highlight the potential application of Fe-Se alloys in robust bifacial DSSCs.

  5. New avenues for ligand-mediated processes--expanding metal reactivity by the use of redox-active catechol, o-aminophenol and o-phenylenediamine ligands.

    PubMed

    Broere, Daniël L J; Plessius, Raoul; van der Vlugt, Jarl Ivar

    2015-10-01

    Redox-active ligands have evolved from being considered spectroscopic curiosities - creating ambiguity about formal oxidation states in metal complexes - to versatile and useful tools to expand on the reactivity of (transition) metals or to even go beyond what is generally perceived possible. This review focusses on metal complexes containing either catechol, o-aminophenol or o-phenylenediamine type ligands. These ligands have opened up a new area of chemistry for metals across the periodic table. The portfolio of ligand-based reactivity invoked by these redox-active entities will be discussed. This ranges from facilitating oxidative additions upon d(0) metals or cross coupling reactions with cobalt(iii) without metal oxidation state changes - by functioning as an electron reservoir - to intramolecular ligand-to-substrate single-electron transfer to create a reactive substrate-centered radical on a Pd(ii) platform. Although the current state-of-art research primarily consists of stoichiometric and exploratory reactions, several notable reports of catalysis facilitated by the redox-activity of the ligand will also be discussed. In conclusion, redox-active ligands containing catechol, o-aminophenol or o-phenylenediamine moieties show great potential to be exploited as reversible electron reservoirs, donating or accepting electrons to activate substrates and metal centers and to enable new reactivity with both early and late transition as well as main group metals. PMID:26148803

  6. Interactive Read-Alouds--An Avenue for Enhancing Children's Language for Thinking and Understanding: A Review of Recent Research

    ERIC Educational Resources Information Center

    Lennox, Sandra

    2013-01-01

    Enhancing young children's early literacy achievement is a top priority in many countries. There is a considerable body of research demonstrating young children's language development as a critical factor in reading and later academic success. Implementation of high quality literacy instruction has the potential to improve literacy…

  7. Implementing an Information Desk: Avenues toward Increased Quality of Reference and Loan Services. Summary and Evaluation of the Information Desk Experiment.

    ERIC Educational Resources Information Center

    Williams, Karen

    During the spring semester of 1987, the University of Arizona implemented an experimental information desk as a means of improving the quality of service to patrons by relieving congestion at the reference desk. Services at this desk, which was staffed by reference personnel during the first phase of the project, included serving as the initial…

  8. Superfund Record of Decision (EPA Region 2): Nascolite Corporation, Doris Avenue, cities of Millville and Vineland, Cumberland County, NJ. (Second remedial action), June 1991. Final report

    SciTech Connect

    Not Available

    1991-06-28

    The 17.5-acre Nascolite site is an inactive acrylic and plexiglass sheet manufacturing plant in Millville, Cumberland County, New Jersey. The site lies within the New Jersey coastal plain and overlies clay, silt, sand, and gravel layers. The majority of the site is wooded, with a wetland located in the southwestern portion. In 1980, although the State ordered the plant to stop discharging wastewaters into the onsite drainage ditch, well water monitoring conducted during 1981 identified VOC-contamination in these wells. In 1984, the State identified over one hundred 55-gallon drums and several underground storage tanks buried onsite. In 1987, the State ordered Nascolite to remove some of the drums, and later during 1987 and 1988, EPA removed the remaining drums offsite. The ROD addresses contaminated onsite soil, sediment, and buildings. The primary contaminant of concern affecting the soil, sediment, and debris is the inorganic contaminant lead; and VOCs including benzene, PCE, TCE, toluene, and xylenes. The selected remedial action for the site is included.

  9. Middlesex Sampling Plant environmental report for calendar year 1992, 239 Mountain Avenue, Middlesex, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Middlesex Sampling Plant (MSP) and provides the results for 1992. The site, in the Borough of Middlesex, New Jersey, is a fenced area and includes four buildings and two storage piles that contain 50,800 m{sup 3} of radioactive and mixed hazardous waste. More than 70 percent of the MSP site is paved with asphalt. The MSP facility was established in 1943 by the Manhattan Engineer District (MED) to sample, store, and/or ship uranium, thorium, and beryllium ores. In 1955 the Atomic Energy Commission (AEC), successor to MED, terminated the operation and later used the site for storage and limited sampling of thorium residues. In 1967 AEC activities ceased, onsite structures were decontaminated, and the site was certified for unrestricted use under criteria applicable at that time. In 1980 the US Department of Energy (DOE) initiated a multiphase remedial action project to clean up several vicinity properties onto which contamination from the plant had migrated. Material from these properties was consolidated into the storage piles onsite. Environmental surveillance of MSP began in 1980 when Congress added the site to DOE`s Formerly Utilized Sites Remedial Action Program. The environmental surveillance program at MSP includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-230, thorium-232, and total uranium in surface water, sediment, and groundwater. Additionally, chemical analyses are performed to detect metals and organic compounds in surface water and groundwater and metals in sediments. This program assists in fulfilling th DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses.

  10. Maywood Interim Storage Site environmental report for calendar year 1992, 100 West Hunter Avenue, Maywood, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Maywood Interim Storage Site (MISS) and provides the results for 1992. Environmental monitoring of MISS began in 1984, when the site was assigned to DOE by Congress through the Energy and Water Development Appropriations Act and was placed under DOE`s Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. MISS is part of a National Priorities List (NPL) site. The environmental surveillance program at MISS includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-232, and total uranium in surface water, sediment, and groundwater. Additionally, chemical analysis includes metals and organic compounds in surface water and groundwater and metals in sediments. This program assists in fulfilling the DOE objective of measuring and monitoring effluents from DOE activities and calculating hypothetical doses to members of the general public. Monitoring results are compared with applicable Environmental Protection Agency (EPA) and state standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements. Environmental standards are established to protect public health and the environment. The radiological data for all media sampled support the conclusion that doses to the public are not distinguishable from natural background radiation.

  11. iDNA from terrestrial haematophagous leeches as a wildlife surveying and monitoring tool - prospects, pitfalls and avenues to be developed.

    PubMed

    Schnell, Ida Bærholm; Sollmann, Rahel; Calvignac-Spencer, Sébastien; Siddall, Mark E; Yu, Douglas W; Wilting, Andreas; Gilbert, M Thomas P

    2015-01-01

    Invertebrate-derived DNA (iDNA) from terrestrial haematophagous leeches has recently been proposed as a powerful non-invasive tool with which to detect vertebrate species and thus to survey their populations. However, to date little attention has been given to whether and how this, or indeed any other iDNA-derived data, can be combined with state-of-the-art analytical tools to estimate wildlife abundances, population dynamics and distributions. In this review, we discuss the challenges that face the application of existing analytical methods such as site-occupancy and spatial capture-recapture (SCR) models to terrestrial leech iDNA, in particular, possible violations of key assumptions arising from factors intrinsic to invertebrate parasite biology. Specifically, we review the advantages and disadvantages of terrestrial leeches as a source of iDNA and summarize the utility of leeches for presence, occupancy, and spatial capture-recapture models. The main source of uncertainty that attends species detections derived from leech gut contents is attributable to uncertainty about the spatio-temporal sampling frame, since leeches retain host-blood for months and can move after feeding. Subsequently, we briefly address how the analytical challenges associated with leeches may apply to other sources of iDNA. Our review highlights that despite the considerable potential of leech (and indeed any) iDNA as a new survey tool, further pilot studies are needed to assess how analytical methods can overcome or not the potential biases and assumption violations of the new field of iDNA. Specifically we argue that studies to compare iDNA sampling with standard survey methods such as camera trapping, and those to improve our knowledge on leech (and other invertebrate parasite) physiology, taxonomy, and ecology will be of immense future value. PMID:26430464

  12. [Practices and interventions related to the work integration of people with a severe mental illness: work outcomes and avenues of research].

    PubMed

    Pachoud, B; Corbière, M

    2014-06-01

    Sustained work integration for people with a severe mental illness or handicap psychique in French (e.g., schizophrenia) is an important issue in our society today. Indeed, work is not only an essential factor in people's social integration but is also a stepping-stone toward recovery for this clientele. Well-defined programs and services related to work integration were developed and studied over the last three decades. Although the work integration of people with severe mental illness has been studied extensively in the Anglo-Saxon literature, the impact of these studies on the traditional beliefs and services in France remains uncertain. In terms of the scope of the studies so far, there has been an initial interest lasting over many years to uncover individual characteristics of people with severe mental illness which would best predict job tenure. Since, studies have been increasingly investigating various supports in order to facilitate the work integration process. These supports can be illustrated as direct supports or accommodations offered in the workplace, as needed, particularly when people with severe mental illness choose to disclose their mental disorder in the workplace. This awareness of the impact of the workplace environment on the work integration of people with a severe mental illness increases the need to find solutions and develop environmentally sensitive clinical strategies to overcome difficulties during the work integration. To illustrate this thematic, in this special issue, we have gathered together studies conducted in different countries but who share the focus on work integration of people with a severe mental illness. To reflect the advancement in this domain, this special issue is divided in three parts. The first part consists of the presentation of different types of vocational programs: supported employment programs, social firms, and hybrid models. Supported employment programs are very well documented in the specialised literature and are recognized as an evidence-based practice across the world to help people get competitive employment. Social firms is an another alternative model for facilitating the work integration of people with severe mental illness but has to date scarcely been studied empirically. Other hybrid vocational programs implemented in Québec (Canada) and France and inspired by supported employment programs and social firms' principles, are also described. The second part of this special issue is related to the presentation of two adjunct clinical interventions for helping people with a severe mental illness in their work integration, and more particularly for increasing job tenure: cognitive remediation and group cognitive behavioral therapy. Cognitive remediation was developed to reduce the impact of cognitive deficits, such as memory or attention, in people with a severe mental illness whereas group cognitive behavioral therapy was developed to change the dysfunctional beliefs and behaviours that might hinder job tenure in people receiving supported employment services. Finally, the third part of this special issue presents two papers on the influence of the workplace, of stakeholders from the organization (e.g., employers, supervisors) and of the work environment on the work integration of people with severe mental illness. The first paper discusses disclosure of the mental illness in the workplace and its positive and negative consequences such as receiving work accommodations and experiencing stigma, respectively. In the last paper, psychological processes during the hiring process are presented to better understand the elements related to discrimination and stigma during the work integration of people with severe mental illness. PMID:24929973

  13. MicroRNAs in Schizophrenia: Implications for Synaptic Plasticity and Dopamine-Glutamate Interaction at the Postsynaptic Density. New Avenues for Antipsychotic Treatment Under a Theranostic Perspective.

    PubMed

    de Bartolomeis, Andrea; Iasevoli, Felice; Tomasetti, Carmine; Buonaguro, Elisabetta F

    2015-12-01

    Despite dopamine-glutamate aberrant interaction that has long been considered a relevant landmark of psychosis pathophysiology, several aspects of these two neurotransmitters reciprocal interaction remain to be defined. The emerging role of postsynaptic density (PSD) proteins at glutamate synapse as a molecular "lego" making a functional hub where different signals converge may add a new piece of information to understand how dopamine-glutamate interaction may work with regard to schizophrenia pathophysiology and treatment. More recently, compelling evidence suggests a relevant role for microRNA (miRNA) as a new class of dopamine and glutamate modulators with regulatory functions in the reciprocal interaction of these two neurotransmitters. Here, we aimed at addressing the following issues: (i) Do miRNAs have a role in schizophrenia pathophysiology in the context of dopamine-glutamate aberrant interaction? (ii) If miRNAs are relevant for dopamine-glutamate interaction, at what level this modulation takes place? (iii) Finally, will this knowledge open the door to innovative diagnostic and therapeutic tools? The biogenesis of miRNAs and their role in synaptic plasticity with relevance to schizophrenia will be considered in the context of dopamine-glutamate interaction, with special focus on miRNA interaction with PSD elements. From this framework, implications both for biomarkers identification and potential innovative interventions will be considered. PMID:25394379

  14. Transcriptome Characterization of Developing Bean (Phaseolus vulgaris L.) Pods from Two Genotypes with Contrasting Seed Zinc Concentrations.

    PubMed

    Astudillo-Reyes, Carolina; Fernandez, Andrea C; Cichy, Karen A

    2015-01-01

    Dry bean (Phaseolus vulgaris L.) seeds are a rich source of dietary zinc, especially for people consuming plant-based diets. Within P. vulgaris there is at least two-fold variation in seed Zn concentration. Genetic studies have revealed seed Zn differences to be controlled by a single gene in two closely related navy bean genotypes, Albion and Voyager. In this study, these two genotypes were grown under controlled fertilization conditions and the Zn concentration of various plant parts was determined. The two genotypes had similar levels of Zn in their leaves and pods but Voyager had 52% more Zn in its seeds than Albion. RNA was sequenced from developing pods of both genotypes. Transcriptome analysis of these genotypes identified 27,198 genes in the developing bean pods, representing 86% of the genes in the P. vulgaris genome (v 1.0 DOE-JGI and USDA-NIFA). Expression was detected in 18,438 genes. A relatively small number of genes (381) were differentially expressed between Albion and Voyager. Differentially expressed genes included three genes potentially involved in Zn transport, including zinc-regulated transporter, iron regulated transporter like (ZIP), zinc-induced facilitator (ZIF) and heavy metal associated (HMA) family genes. In addition 12,118 SNPs were identified between the two genotypes. Of the gene families related to Zn and/or Fe transport, eleven genes were found to contain SNPs between Albion and Voyager. PMID:26367119

  15. Transcriptome Characterization of Developing Bean (Phaseolus vulgaris L.) Pods from Two Genotypes with Contrasting Seed Zinc Concentrations

    PubMed Central

    Astudillo-Reyes, Carolina; Fernandez, Andrea C.; Cichy, Karen A.

    2015-01-01

    Dry bean (Phaseolus vulgaris L.) seeds are a rich source of dietary zinc, especially for people consuming plant-based diets. Within P. vulgaris there is at least two-fold variation in seed Zn concentration. Genetic studies have revealed seed Zn differences to be controlled by a single gene in two closely related navy bean genotypes, Albion and Voyager. In this study, these two genotypes were grown under controlled fertilization conditions and the Zn concentration of various plant parts was determined. The two genotypes had similar levels of Zn in their leaves and pods but Voyager had 52% more Zn in its seeds than Albion. RNA was sequenced from developing pods of both genotypes. Transcriptome analysis of these genotypes identified 27,198 genes in the developing bean pods, representing 86% of the genes in the P. vulgaris genome (v 1.0 DOE-JGI and USDA-NIFA). Expression was detected in 18,438 genes. A relatively small number of genes (381) were differentially expressed between Albion and Voyager. Differentially expressed genes included three genes potentially involved in Zn transport, including zinc-regulated transporter, iron regulated transporter like (ZIP), zinc-induced facilitator (ZIF) and heavy metal associated (HMA) family genes. In addition 12,118 SNPs were identified between the two genotypes. Of the gene families related to Zn and/or Fe transport, eleven genes were found to contain SNPs between Albion and Voyager. PMID:26367119

  16. New Media. [SITE 2001 Section].

    ERIC Educational Resources Information Center

    McNeil, Sara, Ed.

    This document contains the following papers on new media from the SITE (Society for Information Technology & Teacher Education) 2001 conference: "Interactive Multimedia Problem-Based Learning: Evaluating Its Use in Pre-Service Teacher Education" (Peter Albion); "Digital Audio Production for the Web" (Jeffrey W. Bauer and Marianne T. Bauer);…

  17. A Case Study of Liberal Arts Colleges in the 21st Century: Understanding Organizational Change and Evolution in Higher Education

    ERIC Educational Resources Information Center

    Baker, Vicki L.; Baldwin, Roger G.

    2015-01-01

    We draw upon the evolutionary model of change in order to examine the organizational transformation of three liberal arts colleges (Albion College, Allegheny College, Kenyon College). Relying on our prior research (Baker, Baldwin, & Makker, 2012), we seek to continue our exploration and understanding of the evolution occurring in the important…

  18. From Racism to Hope

    ERIC Educational Resources Information Center

    Longhurst, Jessie

    2013-01-01

    This article describes the two-day "Healing in Racism" training received by Jessie Longhurst when she was a teenager in her hometown of Albion, Michigan. She accepted an invitation from her father to attend the program, and states that the training gave her a better understanding of what it means to be African American in our country,…

  19. 76 FR 71124 - Safety Advisory: Unauthorized Marking of Compressed Gas Cylinders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... authorized requalification company and properly marked. FOR FURTHER INFORMATION CONTACT: Morgan Welding and... high pressure DOT cylinders. The evidence suggests that if a cylinder purchased from Morgan Welding and... cylinders from service and contact Morgan Welding and Supply, Albion, MI for further instructions....

  20. Compariative analysis of strawberry total phenolics via fast blue BB vs. folin-ciocalteu: assay interference by ascorbic acid

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Strawberry (Fragaria ×ananassa Duchesne ex Rozier) fruit were harvested from two field plots of five day-neutral cultivars: Albion, Monterey, Portola, San Andreas and Seacape. Marketable (salable) berries were harvested from each plot on 22 and 25 August, and unblemished fully ripe fruit were selec...