Science.gov

Sample records for albright generating stations

  1. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2004-01-01

    During the period October 1, 2003-December 31, 2003, Allegheny Energy Supply Co., LLC (Allegheny) continued with demonstration operations at the Willow Island Generating Station and improvements to the Albright Generating Station cofiring systems. The demonstration operations at Willow Island were designed to document integration of biomass cofiring into commercial operations, including evaluating new sources of biomass supply. The Albright improvements were designed to increase the resource base for the projects, and to address issues that came up during the first year of operations. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations.

  2. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2003-07-01

    During the period April 1, 2003--June 30, 2003, Allegheny Energy Supply Co., LLC (Allegheny) proceeded with demonstration operations at the Willow Island Generating Station and improvements to the Albright Generating Station cofiring systems. The demonstration operations at Willow Island were designed to document integration of biomass cofiring into commercial operations. The Albright improvements were designed to increase the resource base for the projects, and to address issues that came up during the first year of operations. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations.

  3. PROGRESS REPORT: COFIRING PROJECTS FOR WILLOW ISLAND AND ALBRIGHT GENERATING STATIONS

    SciTech Connect

    K. Payette; D. Tillman

    2001-07-01

    During the period April 1, 2001--June 30, 2001, Allegheny Energy Supply Co., LLC (Allegheny) accelerated construction of the Willow Island cofiring project, completed the installation of foundations for the fuel storage facility, the fuel receiving facility, and the processing building. Allegheny received all processing equipment to be installed at Willow Island. Allegheny completed the combustion modeling for the Willow Island project. During this time period construction of the Albright Generating Station cofiring facility was completed, with few items left for final action. The facility was dedicated at a ceremony on June 29. Initial testing of cofiring at the facility commenced. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations. It details the construction activities at both sites along with the combustion modeling at the Willow Island site.

  4. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2003-04-30

    During the period January 1, 2003--March 31, 2003, Allegheny Energy Supply Co., LLC (Allegheny) proceeded with improvements to both the Willow Island and Albright Generating Station cofiring systems. These improvements were designed to increase the resource base for the projects, and to address issues that came up during the first year of operations. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations.

  5. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2001-10-01

    During the period July 1, 2001--September 30, 2001, Allegheny Energy Supply Co., LLC (Allegheny) continued construction of the Willow Island cofiring project, completed the installation of the fuel storage facility, the fuel receiving facility, and the processing building. All mechanical equipment has been installed and electrical construction has proceeded. During this time period significant short term testing of the Albright Generating Station cofiring facility was completed, and the 100-hour test was planned for early October. The testing demonstrated that cofiring at the Albright Generating Station could contribute to a ''4P Strategy''--reduction of SO{sub 2}, NO{sub x}, mercury, and greenhouse gas emissions. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations. It details the construction activities at both sites along with the combustion modeling at the Willow Island site.

  6. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2003-10-01

    During the period July 1, 2003-September 30, 2003, Allegheny Energy Supply Co., LLC (Allegheny) proceeded with demonstration operations at the Willow Island Generating Station and improvements to the Albright Generating Station cofiring systems. The demonstration operations at Willow Island were designed to document integration of bio mass cofiring into commercial operations, including evaluating new sources of biomass supply. The Albright improvements were designed to increase the resource base for the projects, and to address issues that came up during the first year of operations. During this period, a major presentation summarizing the program was presented at the Pittsburgh Coal Conference. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations.

  7. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2002-01-01

    During the period October 1, 2001--December 31, 2001, Allegheny Energy Supply Co., LLC (Allegheny) completed construction of the Willow Island cofiring project. This included completion of the explosion proof electrical wiring, the control system, and the control software. Procedures for system checkout, shakedown, and initial operation were initiated during this period. During this time period the 100-hour test of the Albright Generating Station cofiring facility was completed. The testing demonstrated that cofiring at the Albright Generating Station could reliably contribute to a ''4P Strategy''--reduction of SO{sub 2}, NO{sub x}, mercury, and greenhouse gas emissions over a significant load range. During this period of time Allegheny Energy conducted facility tours of both Albright and Willow Island for the Biomass Interest Group of the Electric Power Research Institute. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations. It details the completion of construction activities at the Willow Island site along with the 100-hr test at the Albright site.

  8. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2003-01-01

    During the period October 1, 2002--December 31, 2002, Allegheny Energy Supply Co., LLC (Allegheny) completed the first year of testing at the Willow Island cofiring project. This included data acquisition and analysis associated with certain operating parameters and environmental results. Over 2000 hours of cofiring operation were logged at Willow Island, and about 4,000 tons of sawdust were burned along with slightly more tire-derived fuel (TDF). The results were generally favorable. During this period, also, a new grinder was ordered for the Albright Generating Station to handle oversized material rejected by the disc screen. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations. It details the test results at Willow Island and summarizes the grinder program at Albright.

  9. DESIGNING AND OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION AND COFIRING SAWDUST WITH COAL AT ALBRIGHT GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2004-06-01

    During the period July 1, 2000-March 31, 2004, Allegheny Energy Supply Co., LLC (Allegheny) conducted an extensive demonstration of woody biomass cofiring at its Willow Island and Albright Generating Stations. This demonstration, cofunded by USDOE and Allegheny, and supported by the Biomass Interest Group (BIG) of EPRI, evaluated the impacts of sawdust cofiring in both cyclone boilers and tangentially-fired pulverized coal boilers. The cofiring in the cyclone boiler--Willow Island Generating Station Unit No.2--evaluated the impacts of sawdust alone, and sawdust blended with tire-derived fuel. The biomass was blended with the coal on its way to the combustion system. The cofiring in the pulverized coal boiler--Albright Generating Station--evaluated the impact of cofiring on emissions of oxides of nitrogen (NO{sub x}) when the sawdust was injected separately into the furnace. The demonstration of woody biomass cofiring involved design, construction, and testing at each site. The results addressed impacts associated with operational issues--capacity, efficiency, and operability--as well as formation and control of airborne emissions such as NO{sub x}, sulfur dioxide (SO{sub 2}2), opacity, and mercury. The results of this extensive program are detailed in this report.

  10. Quantitative and sensitive detection of GNAS mutations causing mccune-albright syndrome with next generation sequencing.

    PubMed

    Narumi, Satoshi; Matsuo, Kumihiro; Ishii, Tomohiro; Tanahashi, Yusuke; Hasegawa, Tomonobu

    2013-01-01

    Somatic activating GNAS mutations cause McCune-Albright syndrome (MAS). Owing to low mutation abundance, mutant-specific enrichment procedures, such as the peptide nucleic acid (PNA) method, are required to detect mutations in peripheral blood. Next generation sequencing (NGS) can analyze millions of PCR amplicons independently, thus it is expected to detect low-abundance GNAS mutations quantitatively. In the present study, we aimed to develop an NGS-based method to detect low-abundance somatic GNAS mutations. PCR amplicons encompassing exons 8 and 9 of GNAS, in which most activating mutations occur, were sequenced on the MiSeq instrument. As expected, our NGS-based method could sequence the GNAS locus with very high read depth (approximately 100,000) and low error rate. A serial dilution study with use of cloned mutant and wildtype DNA samples showed a linear correlation between dilution and measured mutation abundance, indicating the reliability of quantification of the mutation. Using the serially diluted samples, the detection limits of three mutation detection methods (the PNA method, NGS, and combinatory use of PNA and NGS [PNA-NGS]) were determined. The lowest detectable mutation abundance was 1% for the PNA method, 0.03% for NGS and 0.01% for PNA-NGS. Finally, we analyzed 16 MAS patient-derived leukocytic DNA samples with the three methods, and compared the mutation detection rate of them. Mutation detection rate of the PNA method, NGS and PNA-NGS in 16 patient-derived peripheral blood samples were 56%, 63% and 75%, respectively. In conclusion, NGS can detect somatic activating GNAS mutations quantitatively and sensitively from peripheral blood samples. At present, the PNA-NGS method is likely the most sensitive method to detect low-abundance GNAS mutation.

  11. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2001-04-01

    During the period January 1, 2001-March 31, 2001, Allegheny Energy Supply Co., LLC (Allegheny) finalized the engineering of the Willow Island cofiring project, completed the fuel characterizations for both the Willow Island and Albright Generating Station projects, and initiated construction of both projects. Allegheny and its contractor, Foster Wheeler, selected appropriate fuel blends and issued purchase orders for all processing and mechanical equipment to be installed at both sites. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations. The third quarter of the project involved completing the detailed designs for the Willow Island Designer Fuel project. It also included complete characterization of the coal and biomass fuels being burned, focusing upon the following characteristics: proximate and ultimate analysis; higher heating value; carbon 13 nuclear magnetic resonance testing for aromaticity, number of aromatic carbons per cluster, and the structural characteristics of oxygen in the fuel; drop tube reactor testing for high temperature devolatilization kinetics and generation of fuel chars; thermogravimetric analyses (TGA) for char oxidation kinetics; and related testing. The construction at both sites commenced during this quarter, and was largely completed at the Albright Generating Station site.

  12. DESIGNING AN OPPORTUNITY FUEL WITH BIOMASS AND TIRE-DERIVED FUEL FOR COFIRING AT WILLOW ISLAND GENERATING STATION

    SciTech Connect

    K. Payette; D. Tillman

    2001-01-01

    During the period October 1, 2000 - December 31, 2000, Allegheny Energy Supply Co., LLC (Allegheny) executed a Cooperative Agreement with the National Energy Technology Laboratory to implement a major cofiring demonstration at the Willow Island Generating Station Boiler No.2. Willow Island Boiler No.2 is a cyclone boiler. Allegheny also will demonstrate separate injection cofiring at the Albright Generating Station Boiler No.3, a tangentially fired boiler. The Allegheny team includes Foster Wheeler as its primary subcontractor. Additional subcontractors are Cofiring Alternatives and N.S. Harding and Associates. This report summarizes the activities associated with the Designer Opportunity Fuel program, and demonstrations at Willow Island and Albright Generating Stations. The second quarter of the project involved completing the designs for each location. Further, geotechnical investigations proceeded at each site. Preparations were made to perform demolition on two small buildings at the Willow Island site. Fuels strategies were initiated for each site. Test planning commenced for each site. A groundbreaking ceremony was held at the Willow Island site on October 18, with Governor C. Underwood being the featured speaker.

  13. Space Station Freedom solar dynamic power generation

    NASA Technical Reports Server (NTRS)

    Springer, T.; Friefeld, Jerry M.

    1990-01-01

    Viewgraphs on Space Station Freedom solar dynamic power generation are presented. Topics covered include: prime contract activity; key solar dynamic power module requirements; solar dynamic heat receiver technology; and solar concentrator advanced development.

  14. Space Station Freedom solar dynamic power generation

    NASA Technical Reports Server (NTRS)

    Springer, T.; Friefeld, Jerry M.

    1990-01-01

    Viewgraphs on Space Station Freedom solar dynamic power generation are presented. Topics covered include: prime contract activity; key solar dynamic power module requirements; solar dynamic heat receiver technology; and solar concentrator advanced development.

  15. 1. GENERAL VIEW OF FISK STREET ELECTRIC GENERATING STATION COMPLEX, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL VIEW OF FISK STREET ELECTRIC GENERATING STATION COMPLEX, LOOKING SOUTH; IN THE CENTER, BEHIND THE STACK IS THE GENERATING STATION BUILT IN 1959; THE TALL METAL-CLAD BUILDING CONTAINS A COAL BUNKER, COAL PULVERIZER, FURNACE, BOILER, SUPER-HEATER, STEAM PIPES, AND HOT-AIR DUCTS. TO THE RIGHT OF THIS 1959 GENERATING STATION IS THE ORIGINAL POWERHOUSE. - Commonwealth Electric Company, Fisk Street Electrical Generating Station, 1111 West Cermak Avenue, Chicago, Cook County, IL

  16. Next generation SAR demonstration on space station

    SciTech Connect

    Edelstein, Wendy; Kim, Yunjin; Freeman, Anthony; Jordan, Rolando

    1999-01-22

    This paper describes the next generation synthetic aperture radar (SAR) that enables future low cost space-borne radar missions. In order to realize these missions, we propose to use an inflatable, membrane, microstrip antenna that is particularly suitable for low frequency science radar missions. In order to mitigate risks associated with this revolutionary technology, the space station demonstration will be very useful to test the long-term survivability of the proposed antenna. This experiment will demonstrate several critical technology challenges associated with space-inflatable technologies. Among these include space-rigidization of inflatable structures, controlled inflation deployment, flatness and uniform separation of thin-film membranes and RF performance of membrane microstrip antennas. This mission will also verify the in-space performance of lightweight, high performance advanced SAR electronics. Characteristics of this SAR instrument include a capability for high resolution polarimetric imaging. The mission will acquire high quality scientific data using this advanced SAR to demonstrate the utility of these advanced technologies. We will present an inflatable L-band SAR concept for commercial and science applications and a P-band design concept to validate the Biomass SAR mission concept. The ionospheric effects on P-band SAR images will also be examined using the acquired data.

  17. System for a displaying at a remote station data generated at a central station and for powering the remote station from the central station

    NASA Technical Reports Server (NTRS)

    Perry, J. C. (Inventor)

    1980-01-01

    A system for displaying at a remote station data generated at a central station and for powering the remote station from the central station is presented. A power signal is generated at the central station and time multiplexed with the data and then transmitted to the remote station. An energy storage device at the remote station is responsive to the transmitted power signal to provide energizing power for the circuits at the remote station during the time interval data is being transmitted to the remote station. Energizing power for the circuits at the remote station is provided by the power signal itself during the time this signal is transmitted. Preferably the energy storage device is a capacitor which is charged by the power signal during the time the power is transmitted and is slightly discharged during the time the data is transmitted to energize the circuits at the remote station.

  18. 78 FR 782 - Energy Northwest; Columbia Generating Station; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Energy Northwest; Columbia Generating Station; Exemption 1.0 Background Energy Northwest (the licensee) is the holder of Renewed Facility Operating License No. NPF-21, which authorizes operation of the Columbia Generating Station. The...

  19. Cofiring at the Seward Generating Station -- A long term demonstration

    SciTech Connect

    Battista, J.; Tillman, D.; Hughes, E.

    1999-07-01

    GPU Genco, supported by the Electric Power Research Institute and the US Department of Energy, Energy Efficiency and Renewable Energy Office and the Federal Energy Technology Center, is demonstrating cofiring of wood waste with coal using separate injection of prepared wood waste at its Seward Generating Station. The program is based upon 3 previous tests: a program of parametric testing at Shawville Generating Station and two parametric test programs at Seward Generating Station. Foster Wheeler Development Corporation is the primary contractor for the demonstration. The physical plant installed at Seward Generating Station includes a pole barn, a trommel screen, a fuel storage silo, and a pneumatic transport system. Testing of cofiring has been at the 5 to 10% heat input level. This paper summarizes the progression of cofiring testing at GPU Genco, details the facility design and equipment installed at the Seward Generation Station.

  20. Wind generator system for microwave radio relay station

    SciTech Connect

    Yamamura, H.; Eguchi, N.

    1983-10-01

    NTT has introduced a wind generator system at microwave relay stations. It consists of a wind turbine generator as main power source and three diesel driven generators as back up. The wind turbine generator adopts a Darrieus unit as the wind driven blades and generates 8 kW maximum power with strong winds blowing over 15 m/s. Before this introduction, NTT manufactured two different wind turbine generator prototypes, one using a propeller and the other a Darrieus unit, and field tests have been carried out since 1978. This paper describes the field tests and the wind generator system for microwave relay stations.

  1. Sun Glint from Solar Electric Generating Stations

    NASA Image and Video Library

    2004-05-26

    These images, from 8 April 2003 show that depending upon the position of the Sun, the solar power stations in California Mohave Desert can reflect solar energy from their large, mirror-like surfaces directly toward one of NASA Terra cameras.

  2. 76 FR 79227 - Exemption Request Submitted by Oyster Creek Nuclear Generating Station; Exelon Generation Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... COMMISSION Exemption Request Submitted by Oyster Creek Nuclear Generating Station; Exelon Generation Company... Generation Company, LLC (the licensee), for operation of the Oyster Creek Nuclear Generating Station (Oyster... for Oyster Creek and NUREG-1437, Vol. 1, Supplement 28, ``Generic Environmental Impact Statement...

  3. International Space Station (ISS) Addition of Hardware - Computer Generated Art

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This computer generated scene of the International Space Station (ISS) represents the first addition of hardware following the completion of Phase II. The 8-A Phase shows the addition of the S-9 truss.

  4. INVESTIGATION OF WASTE RAG GENERATION AT NAVAL STATION MAYPORT

    EPA Science Inventory

    This report presents the results of an investigation examining pollution prevention alternatives for reducing the volume of waste rags generated at Naval Station Mayport, located near Jacksonville Beach, Florida. he report recommends five specific pollution prevention alternative...

  5. INVESTIGATION OF WASTE RAG GENERATION AT NAVAL STATION MAYPORT

    EPA Science Inventory

    This report presents the results of an investigation examining pollution prevention alternatives for reducing the volume of waste rags generated at Naval Station Mayport, located near Jacksonville Beach, Florida. he report recommends five specific pollution prevention alternative...

  6. 76 FR 19148 - PSEG Nuclear, LLC, Hope Creek Generating Station and Salem Nuclear Generating Station, Units 1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... Station (HCGS) and Salem Nuclear Generating Station, Units 1 and 2 (Salem). Possible alternatives to the proposed action (license renewal) include no action and reasonable alternative energy sources. As discussed... for energy planning decision makers would be unreasonable. This recommendation is based on: (1) The...

  7. Power plant V - Thek generating station

    NASA Astrophysics Data System (ADS)

    Pons, M.

    The design and operating features of a 10 MWe parabolic dish concentrator steam-cycle generating plant are described. The dishes which have 75 sq m area with a concentration factor of 265, were proved in the Themis project. The total field for the 10 MWe would cover 63,100 sq m and require 842 units. Using a water-steam cycle at 50 bars, temperature would never surpass 264 C, with an after-generator condition of 33 bars at 204 C. Preheating the water is intended with a fused salt reservoir containing 570 tons in 350 cu m container, around which condensed water would flow. Maintaining the primary loop at mildly elevated temperatures would permit uninterrupted operation during cloudy periods. A total shutdown would occur if cloudy conditions last more than one hour, and start-up would involve reheating the primary loop, recharging the storage, and then respinning the turbine.

  8. 75 FR 33366 - Exelon Generation Company, LLC; Oyster Creek Nuclear Generating Station; Notice of Withdrawal of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... COMMISSION Exelon Generation Company, LLC; Oyster Creek Nuclear Generating Station; Notice of Withdrawal of..., application for amendment to Facility Operating License No. DPR-16 for the Oyster Creek Nuclear Generating Station (Oyster Creek), located in Ocean County, New Jersey. The proposed amendment would have revised...

  9. Tritium management and removal at Ontario Hydro's nuclear generating stations

    SciTech Connect

    Guglielmi, F.

    1988-09-01

    Tritium of the heavy water systems of Ontario Hydro's Nuclear Generating Stations presents a radiological hazard both to station personnel and to the environment. Careful design of equipment, containment and the use of personal protective equipment reduces but does not remove the hazard. To deal more effectively with the problem, Ontario Hydro plants to remove the tritium in a new facility currently under construction. Accordingly, the management of tritium, by the selective use of the tritium removal facility, will play an important role in reducing the tritium hazards at the stations. This paper describes the models and management techniques used.

  10. 88. Photocopied August 1978. STATION GENERATORS LOOKING EAST FROM THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    88. Photocopied August 1978. STATION GENERATORS LOOKING EAST FROM THE CENTRAL GALLERY, AUGUST 11, 1914. BY THIS DATE MICHIGAN NORTHERN HAD COMPLETED THE INSTALLATION OF GENERATORS IN THE EASTERN HALF OF THE POWER HOUSE AND HAD BEGUN WORK ON THE WEST. THE MOTOR-GENERATORS PURSHASED BY THE M.L.S.P.C. IN 1902 CAN BE SEEN ON THE LEFT BY THE LINE OF COLUMNS. (910) - Michigan Lake Superior Power Company, Portage Street, Sault Ste. Marie, Chippewa County, MI

  11. A Renewably Powered Hydrogen Generation and Fueling Station Community Project

    NASA Technical Reports Server (NTRS)

    Lyons, Valerie J.; Sekura, Linda S.; Prokopius, Paul; Theirl, Susan

    2009-01-01

    The proposed project goal is to encourage the use of renewable energy and clean fuel technologies for transportation and other applications while generating economic development. This can be done by creating an incubator for collaborators, and creating a manufacturing hub for the energy economy of the future by training both white- and blue-collar workers for the new energy economy. Hydrogen electrolyzer fueling stations could be mass-produced, shipped and installed in collaboration with renewable energy power stations, or installed connected to the grid with renewable power added later.

  12. Navajo Generating Station and Air Visibility Regulations: Alternatives and Impacts

    SciTech Connect

    Hurlbut, D. J.; Haase, S.; Brinkman, G.; Funk, K.; Gelman, R.; Lantz, E.; Larney, C.; Peterson, D.; Worley, C.; Liebsch, E.

    2012-01-01

    Pursuant to the Clean Air Act, the U.S. Environmental Protection Agency (EPA) announced in 2009 its intent to issue rules for controlling emissions from Navajo Generating Station that could affect visibility at the Grand Canyon and at several other national parks and wilderness areas. The final rule will conform to what EPA determines is the best available retrofit technology (BART) for the control of haze-causing air pollutants, especially nitrogen oxides. While EPA is ultimately responsible for setting Navajo Generating Station's BART standards in its final rule, it will be the U.S. Department of the Interior's responsibility to manage compliance and the related impacts. This study aims to assist both Interior and EPA by providing an objective assessment of issues relating to the power sector.

  13. Familial Albright`s hereditary osteodystrophy with hypoparathyroidism: Normal structural G{sub s}{alpha} gene

    SciTech Connect

    Shapira, H.; Friedman, E.; Farfel, Z.

    1996-04-01

    Albright`s hereditary osteodystrophy (AHO) is a characteristic skeletal phenotype, including short stature, obesity, round face, and brachydactyly. AHO appears in patients with pseudohypoparathyroidism (PHP) who have resistance to PTH and in their eumetabolic family members who have pseudohypoparathyroidism (PPHP). The differential diagnosis of AHO in families without PHP includes brachydactyly E, whose existence as a distinct entity has been questioned. We studied a patient with familial AHO who presented with hypocalcemia. To our surprise, PTH levels were low, and the response to PTH administration was normal. This is the first case of familial AHO with hypoparathyroidism. The proband`s family included 22 affected subjects spanning 3 generations, who had variable degrees of AHO manifestations, with an autosomal dominant inheritance trait. The metacarpophalangeal pattern profile was typical of that of PHP-PPHP. As deficient activity and inactivating mutations of G{sub s}{alpha} were described in PHP as well as in PPHP, we measured the biological activity of G{sub s} in family members, which was normal. To exclude subtle abnormalities in the G{sub s}{alpha} gene, we sequenced the entire coding region of G{alpha} in the propositus, which was normal. We conclude that hypocalcemia should be adequately evaluated even in the presence of familial AHO, and that familial AHO can occur with a normal coding structural Ga gene. Identification of the molecular defect in familial AHO without PHP will shed light on the pathogenesis of AHO in general. 20 refs., 3 figs.

  14. Next-Generation GPS Station for Hazards Mitigation (Invited)

    NASA Astrophysics Data System (ADS)

    Bock, Y.

    2013-12-01

    Our objective is to better forecast, assess, and mitigate natural hazards, including earthquakes, tsunamis, and extreme storms and flooding through development and implementation of a modular technology for the next-generation in-situ geodetic station to support the flow of information from multiple stations to scientists, mission planners, decision makers, and first responders. The same technology developed under NASA funding can be applied to enhance monitoring of large engineering structures such as bridges, hospitals and other critical infrastructure. Meaningful warnings save lives when issued within 1-2 minutes for destructive earthquakes, several tens of minutes for tsunamis, and up to several hours for extreme storms and flooding, and can be provided by on-site fusion of multiple data types and generation of higher-order data products: GPS/GNSS and accelerometer measurements to estimate point displacements, and GPS/GNSS and meteorological measurements to estimate moisture variability in the free atmosphere. By operating semi-autonomously, each station can then provide low-latency, high-fidelity and compact data products within the constraints of narrow communications bandwidth that often accompanies natural disasters. We have developed a power-efficient, low-cost, plug-in Geodetic Module for fusion of data from in situ sensors including GPS, a strong-motion accelerometer module, and a meteorological sensor package, for deployment at existing continuous GPS stations in southern California; fifteen stations have already been upgraded. The low-cost modular design is scalable to the many existing continuous GPS stations worldwide. New on-the-fly data products are estimated with 1 mm precision and accuracy, including three-dimensional seismogeodetic displacements for earthquake, tsunami and structural monitoring and precipitable water for forecasting extreme weather events such as summer monsoons and atmospheric rivers experienced in California. Unlike more

  15. Engineer and technical training at GPUN's nuclear generating stations

    SciTech Connect

    Coe, R.P. )

    1993-01-01

    GPU Nuclear (GPUN) owns and operates the Oyster Creek and Three Mile Island (TMI) unit I nuclear generating stations. They also continue the recovery efforts of the damaged reactor at TMI-2. Technical training for engineers and support staff is managed by the GPUN Corporate Training Department. The group also manages the Institute of Nuclear Power Operations (INPO)-accredited Engineering Support Personnel (ESP) Training Program and the GPUN New Engineer Training Program. The New Engineer Training Program has been in existence since 1982 and has trained and oriented [approximately]100 new college graduates to the nuclear industry.

  16. 75 FR 52045 - Arizona Public Service Company, Palo Verde Nuclear Generating Station, Unit 3; Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... COMMISSION Arizona Public Service Company, Palo Verde Nuclear Generating Station, Unit 3; Environmental... Palo Verde Nuclear Generating Station (PVNGS), Unit 3, located in Maricopa County, Arizona. Therefore... Statement for the Palo Verde Nuclear Generating Station, NUREG-0841, dated February 1982. Agencies...

  17. Public response to the Diablo Canyon Nuclear Generating Station

    SciTech Connect

    Pijawka, K.D.

    1982-08-01

    The authors examine the nature of the public response to the Diablo Canyon Nuclear Generating Station located in San Luis Obispo, California, from the early 1960s to the present. Four distinct phases of public intervention were discerned, based on change in both plant-related issues and in the nature of the antinuclear constituencies in the region. The level of public concern varied both geographically and temporally and is related to the area's social structure, environmental predispositions, and distribution of plant-related economic benefits. External events, such as the prolonged debate over the risk assessment of the seismic hazard and the Three Mile Island accident were found to be important factors in explaining variation in public concern and political response.

  18. [Recovery of Cushing syndrome revealing McCune-Albright syndrome].

    PubMed

    Halioui-Louhaichi, S; Dridi, Y; Azzabi, O; Selmi, I; Fetni, I; Siala, N; Maherzi, A

    2016-01-01

    Cushing syndrome (CS) is a rare feature of McCune-Albright syndrome. Treatments consist of bilateral adrenalectomy followed by lifelong glucocorticoid and mineralocorticoid treatment. However, cases of spontaneous remission of CS have been reported in the literature. We report a case of McCune-Albright syndrome with CS treated with metyrapone for 30 months with prolonged remission after a 12-year follow-up. Adrenalectomy may be avoided in some cases of CS caused by McCune-Albright syndrome. Metyrapone could be a good alternative to surgical treatment.

  19. Partial Hypopituitarism, Hypoglycemia, and Hyperlipemia in Albright's Dystrophy

    ERIC Educational Resources Information Center

    Sareen, C. K.; And Others

    1974-01-01

    The cases of two mentally retarded adult siblings with the classical features of Albright's osteodystrophy (a disease with characteristics such as short stature and abnormal sexual development) were reported. (Author/DB)

  20. Attached algae of the Lake Erie shoreline near Nanticoke Generating Station

    SciTech Connect

    Kirby, M.K.; Dunford, W.E.

    1981-11-01

    The distribution, species composition, and standing crop of attached algae were surveyed in the splash zone along the shore of Lake Erie from 1971 to 1978 to determine the impact of construction and operation of the Nanticoke Generating Station, a coal-fired power plant. Station operation has had no apparent influence on the spatial distribution of attached algae in the lake stations. However, the discharge of heated condenser cooling water has resulted in an accelerated growth of attached algae in the immediate vicinity of the station early in the growing season, but the effect was not sustained after May. The species composition at sites near the generating station differed from control areas. Three years after the initial operation of the plant the generating station had a lower percent abundance of Cladophora and a higher percent abundance of weakly attached algal species such as Zygnema; this is perhaps attributable to the sheltered conditions in the discharge area of the generating station.

  1. Attached algae of the Lake Erie shoreline near Nanticoke generating station

    SciTech Connect

    Kirby, M.K.; Dunford, W.E.

    1981-01-01

    The distribution, species composition and standing crop of attached algae were surveyed in the splash zone along the shore of Lake Erie from 1971 to 1978 to determine the impact of construction and operation of the Nanticoke Generating Station, a coal-fired power plant. Station operation has had no apparent influence on the spatial distribution of attached algae in the lake stations. However, the discharge of heated condenser cooling water has resulted in an accelerated growth of attached algae in the immediate vicinity of the station early in the growing season, but the effect was not sustained after May. The species composition at sites near the generating station differed from control areas. Three years after the initial operation of the plant the generating station had a lower percent abundance of Cladophora and a higher percent abundance of weakly attached algal species such as Zygnema; this is perhaps attributable to the sheltered conditions in the discharge area of the generating station.

  2. 76 FR 75876 - Record of Decision for the Modification of the Groton Generation Station Interconnection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... Electric Power Cooperative (Basin Electric) to modify its Large Generator Interconnection Agreement (LGIA) with Basin Electric for the Groton Generation Station to eliminate current operating limits on the... has decided to modify its LGIA with Basin Electric for the Groton Generation Station eliminating...

  3. ISSLIVE! Bringing the Space Station to Every Generation

    NASA Technical Reports Server (NTRS)

    Harris, Philip D.; Price, Jennifer B.; Severance, Mark; Blue, Regina; Khan, Ahmed; Healy, Matthew D.; Ehlinger, Jesse B.

    2011-01-01

    Just 200 miles above us, the International Space Station (ISS) is orbiting. Each day, the astronauts on board perform a variety of activities from exercise, science experiments, and maintenance. Yet, many on the ground don?t know about these daily activities. ISSLive! - an education project - is working to bridge this knowledge gap with traditional education channels such as schools, but also non-traditional channels with the non-technical everyday public. ISSLive! provides a website that seamlessly integrates planning and telemetry data, video feeds, 3D models, and iOS and android applications. Through the site, users are able to view astronauts? daily schedules, in plain English alongside the original data. As an example, when an astronaut is working with a science experiment, a user will be able to read about the activity and for more detailed activities follow provided links to view more information -- all integrated into the same site. Live telemetry data from a predefined set can also be provided alongside the activities. For users to learn more, 3D models of the external and internal parts of the ISS are available, allowing users to explore the station and even select sensors, such as temperature, and view a real-time chart of the data. Even ground operations are modelled with a 3D mission control center, providing users information on the various flight control disciplines and showing live data that they would be monitoring. Some unique activities are also highlighted, and have dedicated spaces to explore in more detail. Education is the focus of ISSLive!, even from the beginning when university students participated in the development process as part of their master?s projects. Focus groups at a Houston school showed interest in the project, and excitement towards including ISSLive! in their classroom. Through this inclusion, student?s knowledge can be assessed with projects, oral presentations, and other assignments. For the public citizens outside of the

  4. Converting Limbo Lands to Energy-Generating Stations: Renewable Energy Technologies on Underused, Formerly Contaminated Sites

    SciTech Connect

    Mosey, G.; Heimiller, D.; Dahle, D.; Vimmerstedt, L.; Brady-Sabeff, L.

    2007-10-01

    This report addresses the potential for using 'Limbo Lands' (underused, formerly contaminated sites, landfills, brownfields, abandoned mine lands, etc. ) as sites for renewable energy generating stations.

  5. Impact of air pollution on vegetation near the Columbia Generating Station - Wisconsin power plant impact study

    SciTech Connect

    Tibbitts, T.W.; Will-Wolf, S.; Karnowsky, D.F.; Olszyk, D.M.

    1982-06-01

    The impact of air pollution from the coal-fired Columbia Generating Station upon vegetation was investigated. Air monitoring of 03 and 02 documented levels that occurred before and with operation of the generating station. Field sampling of alfalfa, lichens, and white pines was undertaken before and after initiation of generating station operations. Controlled environmental exposures were undertaken with separate cultivars of crop species grown in the vicinity of the generating station. Alfalfa, carrots, mint, peas, beans, and trembling aspen were exposed to SO2 and O3 to establish minimum threshold pollutant levels for injury from these pollutants.

  6. VentureStar Space Station Docking - Computer generated graphic

    NASA Technical Reports Server (NTRS)

    1996-01-01

    This 42-second clip has the cargo bay doors of the hypothetical future reusable launch vehicle VentureStar opening to reveal the bay door radiators and docking module then slowly approaching the International Space Station and finally docking at Pressurized Mating Adapter #2 attached to node two of the Station.

  7. VentureStar Space Station Docking - Computer generated graphic

    NASA Technical Reports Server (NTRS)

    1996-01-01

    This 42-second clip has the cargo bay doors of the hypothetical future reusable launch vehicle VentureStar opening to reveal the bay door radiators and docking module then slowly approaching the International Space Station and finally docking at Pressurized Mating Adapter #2 attached to node two of the Station.

  8. 76 FR 54502 - Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... Generating Station is located in Richland, Washington. Possible alternatives to the proposed action (license renewal) include no action and reasonable alternative energy sources. Any interested party may submit... COMMISSION Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to...

  9. 33 CFR 165.554 - Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County, Pennsylvania. 165.554 Section 165.554 Navigation and... Areas Fifth Coast Guard District § 165.554 Security Zone; Three Mile Island Generating Station...

  10. 33 CFR 165.554 - Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County, Pennsylvania. 165.554 Section 165.554 Navigation and... Areas Fifth Coast Guard District § 165.554 Security Zone; Three Mile Island Generating Station...

  11. 33 CFR 165.554 - Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County, Pennsylvania. 165.554 Section 165.554 Navigation and... Areas Fifth Coast Guard District § 165.554 Security Zone; Three Mile Island Generating Station...

  12. 33 CFR 165.554 - Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County, Pennsylvania. 165.554 Section 165.554 Navigation and... Areas Fifth Coast Guard District § 165.554 Security Zone; Three Mile Island Generating Station...

  13. 33 CFR 165.554 - Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; Three Mile Island Generating Station, Susquehanna River, Dauphin County, Pennsylvania. 165.554 Section 165.554 Navigation and... Areas Fifth Coast Guard District § 165.554 Security Zone; Three Mile Island Generating Station...

  14. 26. Photocopy of diagram (from Bernhardt Skrotzki's Electric GenerationSteam Stations, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Photocopy of diagram (from Bernhardt Skrotzki's Electric Generation--Steam Stations, New York, New York, 1956, figure I-1) THE GENERAL WAY IN WHICH ELECTRICITY IS CREATED THROUGH THE STEAM GENERATION PROCESS - Portland General Electric Company, Station "L", 1841 Southeast Water Street, Portland, Multnomah County, OR

  15. 75 FR 5631 - Wolf Creek Nuclear Operating Corporation, Wolf Creek Generating Station; Environmental Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ... COMMISSION Wolf Creek Nuclear Operating Corporation, Wolf Creek Generating Station; Environmental Assessment... Wolf Creek Nuclear Operating Corporation (WCNOC, the licensee), for operation of the Wolf Creek... Statement for License Renewal of Nuclear Plants: Wolf Creek Generating Station--Final Report (NUREG-1437...

  16. The third generation SLR station Potsdam no. 7836

    NASA Technical Reports Server (NTRS)

    Fischer, H.; Grunwaldt, Ludwig; Neubert, Reinhart

    1993-01-01

    The new satellite laser ranging (SLR) station Potsdam has been installed during the winter of 1991/1992 in an existing dome near the old ruby laser at Helmert Tower. It has been built around a one-meter-Coude telescope and is equipped by a 50 ps Nd:YAG laser and a SPAD receiver. The first successful Lageos passes were obtained in May 1992 demonstrating 2-3 cm rms at the single photon level. The new station will be used for experimental work and selected campaigns as well.

  17. A healthful options food station can improve satisfaction and generate gross profit in a worksite cafeteria.

    PubMed

    Kimathi, Amber N; Gregoire, Mary B; Dowling, Rebecca A; Stone, Marcelle K

    2009-05-01

    The objectives of this study were to determine customer satisfaction with a healthful options food station offered in a worksite cafeteria and document the financial contribution of such a station. The healthful options station featured daily entrées with fewer than 500 calories and less than 30% of calories from fat. Questionnaires from 655 (24.5% response) employees and students provided data on satisfaction with and usage of the station. The majority of the respondents who had purchased from the healthful options station were female (77.3%), white (51.6%), aged 30 to 50 years (52.0%), and had annual incomes of $60,000 to $100,000 (29.3%) or $20,000 to $39,999 (22.2%). Sales and gross profit from the healthful options station were compared to those of the comfort station. Customers were satisfied with attributes of the healthful options station (means >3 on a 5-point scale). Results of paired t tests suggested that customers who had purchased from the healthful options station rated the station significantly (P<0.001) higher for healthfulness of entrées, food presentation, food quality, overall quality of the cafeteria, length of line, and food choices available compared to their ratings for the cafeteria in general. The healthful options station generated average daily sales of $458 and gross profit of $306. However, the sales and gross profit were significantly (P<0.05) less than the comparison comfort station.

  18. [McCune-Albright syndrome associated with diabetes mellitus].

    PubMed

    Chihaoui, M; Hamza, N; Lamine, F; Jabeur, S; Yazidi, M; Ftouhi, B; Slimane, H

    2012-03-01

    McCune-Albright syndrome (MAS) consists of the triad of polyostotic fibrous dysplasia, cutaneous pigmentation, and multiple endocrine abnormalities. Type 1 diabetes mellitus is not included in MAS. We report the case of an 18-year-old girl who presented with McCune-Albright syndrome. The diagnosis was made by the presence of precocious puberty at the age of 6 years, cutaneous pigmentation, polyostotic fibrous dysplasia, and phosphate diabetes. Type 1 diabetes mellitus developed at the age of 16 years. We discuss this case, the relationship between type 1 diabetes mellitus and MAS, with a literature review.

  19. 77 FR 61645 - Exelon Generation Company, LLC, Victoria County Station Site; Notice of Withdrawal of Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... COMMISSION Exelon Generation Company, LLC, Victoria County Station Site; Notice of Withdrawal of Application...) submitted an application for an Early Site Permit (ESP) for the Victoria County Station (VCS) site located in Victoria County, Texas to the U.S. Nuclear Regulatory Commission (NRC or the Commission)...

  20. Inspiring the Next Generation: The International Space Station Education Accomplishments

    NASA Technical Reports Server (NTRS)

    Alleyne, Camille W.; Hasbrook, Pete; Knowles, Carolyn; Chicoine, Ruth Ann; Miyagawa, Yayoi; Koyama, Masato; Savage, Nigel; Zell, Martin; Biryukova, Nataliya; Pinchuk, Vladimir; hide

    2014-01-01

    The International Space Station (ISS) has a unique ability to capture the imagination of both students and teachers worldwide. Since 2000, the presence of humans onboard ISS has provided a foundation for numerous educational activities aimed at capturing that interest and motivating study in the sciences, technology, engineering and mathematics (STEM). Over 43 million students around the world have participated in ISS-related educational activities. Projects such as YouTube Space Lab, Sally Ride Earth Knowledge-based Acquired by Middle Schools (EarthKAM), SPHERES (Synchronized Position Hold Engage and Reorient Experimental Satellites) Zero-Robotics, Tomatosphere, and MAI-75 events among others have allowed for global student, teacher and public access to space through student classroom investigations and real-time audio and video contacts with crewmembers. Educational activities are not limited to STEM but encompass all aspects of the human condition. This is well illustrated in the Uchu Renshi project, a chain poem initiated by an astronaut while in space and continued and completed by people on Earth. With ISS operations now extended to 2024, projects like these and their accompanying educational materials are available to more students around the world. From very early on in the program's history, students have been provided with a unique opportunity to get involved and participate in science and engineering projects. Many of these projects support inquiry-based learning that allows students to ask questions, develop hypothesis-derived experiments, obtain supporting evidence and identify solutions or explanations. This approach to learning is well-published as one of the most effective ways to inspire students to pursue careers in scientific and technology fields. Ever since the first space station element was launched, a wide range of student experiments and educational activities have been performed, both individually and collaboratively, by all the

  1. Main Generator Seal Oil Supply Reliability Improvements at Southern California Edison's San Onofre Nuclear Generating Station

    SciTech Connect

    Simma, Fred Y.; Chetwynd, Russell J.; Rowe, Stuart A.

    2006-07-01

    This paper presents the justification for the approach, details and results of the Main Generator Seal Oil System reliability enhancements on the San Onofre Nuclear Generating Station, SONGS. The SONGS, Unit 3 experienced substantial turbine damage in early 2001 after the turbine bearings lubrication oil supply failed. During a loss of off-site power incident, power was lost to the two AC powered turbine lubrication oil pumps due to a breaker failure in the switchgear and the DC powered emergency bearing lubricating oil pump failed to start due to a breaker trip. The SONGS turbine generators coasted down from full speed to a full stop without lubricating oil. This resulted in significant bearing, journal and steam path damage that required a four-month duration repair outage during a time period where electricity was in short supply in the State of California. The generator hydrogen sealing system remained operable during this event, however it was recognized during the event follow up investigation that this system had vulnerabilities to failure similar to the bearing lubrication system. In order to prevent a reoccurrence of this extremely costly event, SONGS has taken actions to modify both of these critical turbine generator systems by adding additional, continuously operating pumps with a new, independent power source and independently routed cables. The main challenge was to integrate the additional equipment into the existing lubrication and seal oil systems. The lubrication Oil System was the first system to be retro-fitted and these results already have been presented. Reference 2. This paper provides the result of the reliability enhancements for the Main Generator Seal Oil System, which concludes the turbine/generator critical oil systems reliability improvements, performed by SONGS. It is worth noting that the design team discovered and corrected a number of other significant operational issues, which had been present from the early days and also learned

  2. Converting Limbo Lands to Energy-Generating Stations: Renewable Energy Technologies on Underused, Formerly Contaminated Sites

    EPA Science Inventory

    This report addresses the potential for using "Limbo Lands" as sites for renewable energy generating stations. Limbo Lands are considered as underused, formerly contaminated sites, and include former Superfund sites, landfills, brownfields, abandoned mine lands, former industrial...

  3. GHG PSD Permit: Cheyenne Light, Fuel & Power / Black Hills Power, Inc. – Cheyenne Prairie Generating Station

    EPA Pesticide Factsheets

    This page contains the final PSD permit for the Cheyenne Light, Fuel & Power / Black Hills Power, Inc. Cheyenne Prairie Generating Station, located in Laramie, Wyoming, and operated by Black Hills Service Company.

  4. 77 FR 33004 - Exelon Generation Company, LLC; Clinton Power Station, Unit 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Exelon Generation Company, LLC; Clinton Power Station, Unit 1 AGENCY: Nuclear Regulatory... request for partial site release to Facility Operating License No. NPF-62 issued to Exelon...

  5. Converting Limbo Lands to Energy-Generating Stations: Renewable Energy Technologies on Underused, Formerly Contaminated Sites

    EPA Science Inventory

    This report addresses the potential for using "Limbo Lands" as sites for renewable energy generating stations. Limbo Lands are considered as underused, formerly contaminated sites, and include former Superfund sites, landfills, brownfields, abandoned mine lands, former industrial...

  6. Approach of virtual observations generation of a multi-reference GPS station network

    NASA Astrophysics Data System (ADS)

    Yu, Guorong

    2007-11-01

    The generation of virtual reference station observations to relay the corrections to the rover receiver for use with standard RTK software is one of important architectures of reference station networks RTK positioning. The approach of virtual observations generation based on a multi-reference GPS station network is presented in this paper. Ambiguities for the baselines in the reference network are determined firstly. The inter-reference-station differential spatially-correlated errors are estimated using highly accurate coordinates of the reference stations and resolved ambiguities. These spatially-correlated errors are interpolated among the network region as corrections. These network-generated corrections are used to correct the zero-differential observables of one reference station, which is usually the closest one to the rover (the so-called primary reference station). These corrected zero-differential observables, named virtual observations, are processed using conventional single reference station differential GPS algorithms. A test conducted using regional reference networks in Jiangsu(China) demonstrates the effectiveness of the approach to reduce the time to integer ambiguity resolution, and to increase the distance over which centimeter level accuracies can be achieved.

  7. Acromegaly and McCune-Albright Syndrome

    PubMed Central

    Salenave, Sylvie; Boyce, Alison M.; Collins, Michael T.

    2014-01-01

    Background: McCune-Albright syndrome (MAS) includes the triad of poly/monostotic fibrous dysplasia, café-au-lait spots, and hyperfunctioning endocrinopathies. Acromegaly affects around 20% of MAS patients. Aims: The objective was to review all reported cases of acromegaly associated with MAS. Methods: All studies and case reports of acromegaly in patients with MAS were systematically sought in the world literature up to January 2013. We also included new data (from three unreported cases) and updated data on 23 previously reported patients from our two centers. Results: We reviewed the cases of 112 patients (65 males). Mean age at diagnosis of acromegaly was 24.4 years (range, 3–64). Among the 40 pediatric patients, 23 (57%) had precocious puberty. GH/IGF-1 excess was suggested by accelerated growth in 85% of pediatric cases. Acromegaly was almost always associated with skull base fibrous dysplasia. Modern imaging techniques (computed tomography or magnetic resonance imaging) revealed an adenoma in 54% of the patients (macroadenoma in more than two-thirds). Median GH levels and mean IGF-1 SD score at diagnosis were 57 μg/L (2.8 to 291 μg/L) and 8 (2.3 to 24), respectively. Hyperprolactinemia was present in 81% (mean, 149 μg/L; range, 21–600). Pituitary surgery, performed in 25 cases, very rarely cured the GH/IGF-1 excess. Somatostatin analogs improved GH/IGF-1 levels in most patients but achieved control of acromegaly in only 17 (30%) of 56 patients. Pegvisomant achieved normal IGF-1 levels in 10 of 13 cases. Conclusion: Acromegaly, which is present in 20–30% of patients with MAS, raises particular diagnostic and therapeutic issues. PMID:24517150

  8. Genetics Home Reference: McCune-Albright syndrome

    MedlinePlus

    ... Albright syndrome . The thyroid gland , a butterfly-shaped organ at the base of the neck, may become enlarged (a condition called a goiter) or develop masses called nodules. About 50 percent of affected individuals produce excessive amounts of thyroid hormone (hyperthyroidism), ...

  9. Impact assessment of respirable suspended particulate matter from diesel generator sets used for pumping station.

    PubMed

    Talwar, B; Pipalatkar, P; Gajghate, D G; Nema, P

    2010-10-01

    Prediction of respirable suspended particulate matter impacts of diesel generator sets used for pumping station has been made using meteorological data, information on stack characteristics and emission rate, baseline ambient particulate matter and Industrial Source Complex Short Term (ISCST-3) model. It is observed that particulate matter emission from pumping station-S workplace diesel generator sets ranged from 2.4 to 436.5 mg Nm⁻³ and while at pumping station-C, it ranged from 23.2 to 186.5 mg Nm⁻³. The predicted and ambient respirable suspended particulate matter concentrations are below the national air quality standard for respirable suspended particulate matter in a mixed industrial area. Metals contents in respirable suspended particulate matter indicate the origin of crustal and mobile sources. Therefore, the impact of diesel generator sets used for pumping of crude oil on local air quality would be acceptable.

  10. Is central station generation becoming a white elephant

    SciTech Connect

    Ferguson, J.S.

    1985-03-21

    Cost increases encourage the development of alternative sources of energy, and some of the alternatives currently under development lend themselves to moving the generation location back to load centers. In addition, some alternative sources have short lead times and minimal environmental impact, and are being subsidized through income tax policy. Alternative sources of energy have the potential for beginning to affect the usefulness of electric-generating plants and their high-voltage transmission networks before the end of this century. If this comes about, the electric utility industry may find its position similar to that of the telephone industry - with obsolete facilities not fully depreciated. The scenario discussed here would not come about all at once and may not come about at all. But it is the authors opinion that the chances are greater than fifty-fifty that it or something similar will affect the usefulness of bulk power supply systems sometime during the lifetime of generating units installed during the past ten years.

  11. Gas-turbine expander power generating systems for internal needs of compressor stations of gas-main pipelines

    NASA Astrophysics Data System (ADS)

    Shimanov, A. A.; Biryuk, V. V.; Sheludko, L. P.; Shabanov, K. Yu.

    2017-08-01

    In the framework of this paper, there have been analyzed power station building methods to construct a power station for utilities for gas-main pipelines compressor stations. The application efficiency of turbo expanders in them to expand the power gas of compressor stations' gas compressor units has been shown. New schemes for gas-turbine expander power generating systems have been proposed.

  12. International Space Station United States Oxygen Generator Development Testing

    NASA Technical Reports Server (NTRS)

    Erickson, Robert J.; Mason, Richard K.

    2000-01-01

    A life test of a liquid anode feed oxygen generator assembly (OGA) using SPE(R) (United Technologies Corporation, Hamilton Sundstrand Division) membrane technology was terminated in June of 1999. In the total 15,658 hours of operation at MSFC since delivery in 1995, the OGA has produced 2,103 kilograms (kg) (4,632 pounds mass (lbm)) of oxygen, and 263 kg (579 lbm) of hydrogen. Evaluation of cell stack characteristics and oxygen and hydrogen hydrophilic/hydrophobic membrane separators will be discussed.

  13. Acquisition of wood fuel at the Joseph C. McNeil Generating Station

    SciTech Connect

    Kropelin, W.

    1993-12-31

    The Joseph C. McNeil Generating Station is the world`s largest single boiler, municipally-owned, wood-fired electrical generating plant. The 50 megawatt McNeil Station is located in Burlington, Vermont and is owned by several Vermont public and private electric utilities. The operator and majority owner is the City of Burlington Electric Department (BED). Wood fuel procurement for the McNeil Station has been conducted in an environmentally sensitive way. Harvesting is carried out in conformance with a comprehensive wood chip harvesting policy and monitored by professional foresters. Unpredictable levels of Station operation require rigid adherence to a wood storage plan that minimizes the risk of over heating and spontaneous combustion of stockpiled fuel.

  14. Central station applications planning activities and supporting studies. [application of photovoltaic technology to power generation plants

    NASA Technical Reports Server (NTRS)

    Leonard, S. L.; Siegel, B.

    1980-01-01

    The application of photovoltaic technology in central station (utility) power generation plants is considered. A program of data collection and analysis designed to provide additional information about the subset of the utility market that was identified as the initial target for photovoltaic penetration, the oil-dependent utilities (especially muncipals) of the U.S. Sunbelt, is described along with a series of interviews designed to ascertain utility industry opinions about the National Photovoltaic Program as it relates to central station applications.

  15. Latest developments in advanced network management and cross-sharing of next-generation flux stations

    NASA Astrophysics Data System (ADS)

    Burba, George; Johnson, Dave; Velgersdyk, Michael; Begashaw, Israel; Allyn, Douglas

    2016-04-01

    In recent years, spatial and temporal flux data coverage improved significantly and on multiple scales, from a single station to continental networks, due to standardization, automation, and management of the data collection, and better handling of the extensive amounts of generated data. However, operating budgets for flux research items, such as labor, travel, and hardware, are becoming more difficult to acquire and sustain. With more stations and networks, larger data flows from each station, and smaller operating budgets, modern tools are required to effectively and efficiently handle the entire process, including sharing data among collaborative groups. On one hand, such tools can maximize time dedicated to publications answering research questions, and minimize time and expenses spent on data acquisition, processing, quality control and overall station management. On the other hand, cross-sharing the stations with external collaborators may help leverage available funding, and promote data analyses and publications. A new low-cost, advanced system, FluxSuite, utilizes a combination of hardware, software and web-services to address these specific demands. It automates key stages of flux workflow, minimizes day-to-day site management, and modernizes the handling of data flows: (i) The system can be easily incorporated into a new flux station, or as un upgrade to many presently operating flux stations, via weatherized remotely-accessible microcomputer, SmartFlux 2, with fully digital inputs (ii) Each next-generation station will measure all parameters needed for flux computations in a digital and PTP time-synchronized mode, accepting digital signals from a number of anemometers and data loggers (iii) The field microcomputer will calculate final fully-processed flux rates in real time, including computation-intensive Fourier transforms, spectra, co-spectra, multiple rotations, stationarity, footprint, etc. (iv) Final fluxes, radiation, weather and soil data will

  16. Modeling of a horizontal steam generator for the submerged nuclear power station concept

    SciTech Connect

    Palmrose, D.E.; Herring, J.S.

    1993-01-01

    A submerged nuclear power station has been proposed as an alternative power station with a relatively low environmental impact for use by both industrialized and developing countries. The station would be placed 10 m above the seabed at a depth of 30--100 m and a distance of 10--30 km from shore. The submerged nuclear power station would be manufactured and refueled in a central facility, thus gaining the economies of factoryfabrication and the flexibility of short-lead-time deployment. To minimize the size of the submerged hull, horizontal steam generators are proposed for the primary-to-secondary heat transfer, instead of the more traditional vertical steam generators. The horizontal steam generators for SNPS would be similar in design to the horizontal steam generators used in the N-Reactors except the tube orientation is horizontal (the tube's inlet and outlet connection points on the tubesheet are at the same elevation). Previous RELAP5 input decks for horizontal steam generators have been either very simplistic (Loviisa PWR) or used a vertical tube orientation (N-Reactor). This paper will present the development and testing of a RELAP5 horizontal steam generator model, complete with a simple secondary water level control system, that accounts for the dynamic flow conditions which exist inside horizontal steam generators.

  17. Modeling of a horizontal steam generator for the submerged nuclear power station concept

    SciTech Connect

    Palmrose, D.E.; Herring, J.S.

    1993-05-01

    A submerged nuclear power station has been proposed as an alternative power station with a relatively low environmental impact for use by both industrialized and developing countries. The station would be placed 10 m above the seabed at a depth of 30--100 m and a distance of 10--30 km from shore. The submerged nuclear power station would be manufactured and refueled in a central facility, thus gaining the economies of factoryfabrication and the flexibility of short-lead-time deployment. To minimize the size of the submerged hull, horizontal steam generators are proposed for the primary-to-secondary heat transfer, instead of the more traditional vertical steam generators. The horizontal steam generators for SNPS would be similar in design to the horizontal steam generators used in the N-Reactors except the tube orientation is horizontal (the tube`s inlet and outlet connection points on the tubesheet are at the same elevation). Previous RELAP5 input decks for horizontal steam generators have been either very simplistic (Loviisa PWR) or used a vertical tube orientation (N-Reactor). This paper will present the development and testing of a RELAP5 horizontal steam generator model, complete with a simple secondary water level control system, that accounts for the dynamic flow conditions which exist inside horizontal steam generators.

  18. Static analysis of rectifier cabinet for nuclear power generating stations based on finite element method

    NASA Astrophysics Data System (ADS)

    Yin, Qiang; Chen, Tian-jin; Li, Wei-yang; Xiong, Ze-cheng; Ma, Rui

    2017-09-01

    In order to obtain the deformation map and equivalent stress distribution of rectifier cabinet for nuclear power generating stations, the quality distribution of structure and electrical are described, the tensile bond strengths of the rings are checked, and the finite element model of cabinet is set up by ANSYS. The transport conditions of the hoisting state and fork loading state are analyzed. The deformation map and equivalent stress distribution are obtained. The attentive problems are put forward. It is a reference for analysis method and the obtained results for the transport of rectifier cabinet for nuclear power generating stations.

  19. Oral manifestations of McCune-Albright syndrome.

    PubMed

    Aravinda, Konidena; Ratnakar, Pamula; Srinivas, Kandakurti

    2013-01-01

    McCune- Albright Syndrome (MAS) is a rare fibrosseous lesion, characterized by a classic triad of polyostotic fibrous dysplasia (PFD), café -au-lait macules (CALM) and underlying endocrinopathies. We present the oral findings of an interesting case of MAS with relevant review of literature. A 30-year-old male presented to us with swelling of both jaws over a period of two years. Cutaneous examination revealed café - au - lait macule over the back, crossing the midline. Skeletal survey showed expansile, osteolytic, mixed radiolucent- radiopaque lesions in skull and jaw bones. Serum alkaline phosphatase was elevated (388 IU/L), with normal calcium, phosphorus, parathyroid hormone and 25 hydroxy vitamin D levels. Diagnosis of McCune- Albright syndrome was made and he was treated with parenteral bisphosphonates (intravenous Zoledronate 4 mg) and is under follow up for surgical recontouring of the jaws. Early recognition facilitates better treatment and improves prognosis by reducing the morbidity.

  20. Hansen's disease with McCune-Albright syndrome.

    PubMed

    Kumar, Kvs Hari; Dhull, P; Bisht, Ys

    2012-10-01

    McCune-Albright syndrome (MAS) comprises a triad of fibrous dysplasia of bone, café-au-lait macule, and endocrinopathy. The disease is due to activating mutation of G protein-coupled receptor leading to hyperfunction of glands. Hansen's disease is caused by infection with Mycobacterium leprae and is seen with underlying immunosuppressed conditions in genetically predisposed individuals. We recently encountered a patient with Hansen's disease along with underlying MAS and report the same in this report.

  1. Hansen's disease with McCune–Albright syndrome

    PubMed Central

    Kumar, KVS Hari; Dhull, P; Bisht, YS

    2012-01-01

    McCune–Albright syndrome (MAS) comprises a triad of fibrous dysplasia of bone, café-au-lait macule, and endocrinopathy. The disease is due to activating mutation of G protein-coupled receptor leading to hyperfunction of glands. Hansen's disease is caused by infection with Mycobacterium leprae and is seen with underlying immunosuppressed conditions in genetically predisposed individuals. We recently encountered a patient with Hansen's disease along with underlying MAS and report the same in this report. PMID:23326081

  2. 76 FR 1197 - Arizona Public Service Company, Palo Verde Nuclear Generating Station; Notice of Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... additional 20 years of operation for the Palo Verde Nuclear Generating Station (PVNGS). Possible alternatives to the proposed action (license renewal) include no action and reasonable alternative energy sources... renewal for energy planning decision makers would be unreasonable. This recommendation is based on: (1...

  3. 77 FR 22361 - Energy Northwest, Columbia Generating Station; Final Supplement 47 to the Generic Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... site is located approximately 12 miles north of Richland, WA. Possible alternatives to the proposed action (license renewal) include no action and reasonable alternative energy sources. ADDRESSES: Please... COMMISSION Energy Northwest, Columbia Generating Station; Final Supplement 47 to the Generic Environmental...

  4. 77 FR 56238 - Wolf Creek Nuclear Operating Corporation, Wolf Creek Generating Station; Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... COMMISSION Wolf Creek Nuclear Operating Corporation, Wolf Creek Generating Station; Application for Amendment... Public Documents'' and then select ``Begin Web- based ADAMS Search.'' For problems with ADAMS, please... Commission (NRC or the Commission) has granted the request of Wolf Creek Nuclear Operating Corporation (the...

  5. 75 FR 10328 - Wolf Creek Nuclear Operating Corporation, Wolf Creek Generating Station; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... Operating Corporation, Wolf Creek Generating Station; Exemption 1.0 Background Wolf Creek Nuclear Operating Corporation (WCNOC, the licensee) is the holder of Renewed Facility Operating License No. NPF-42, which... those previously imposed by Commission orders issued after the terrorist attacks of September 11, 2001...

  6. Implementation of human factors considerations in a coal fired generating station control room

    SciTech Connect

    Higginbotham, J.W.

    1985-04-01

    Fossil fueled generating station control room design has followed a basically classical approach until recent years. However, as technological advances occurred and were retrofitted into these control rooms, some clashes occurred between the environment and the equipment which negatively impacted the operator's effectiveness. One utility's approach toward implementing the incorporation of new technology devices and of solving the resulting human factors problems is discussed.

  7. Using MapReduce to Improve the Power Generation of the International Space Station

    NASA Astrophysics Data System (ADS)

    Marchetto, William R., II

    The International Space Station (ISS) spends approximately 98% of its time in orbits that experience Earth eclipse. Since the station's solar arrays produce no power when in Earth's shadow, the total power generated decreases substantially, lowering the power budget available to experimental payloads. Therefore, increasing the power output during these eclipsed orbits would be of great benefit to the space station's scientific endeavors. The ISS's current solar array configuration tracks the Sun throughout each orbit, keeping each of its 16 solar panels perpendicular to the Sun at all times. While this is the optimal orientation for solar panels with unobstructed views of the Sun, the space station's solar arrays experience shadowing from the spacecraft's structure as well as from the other solar panels. Deviating from the Sun-tracking scheme at strategic points in certain orbits can provide an increase in power output. The goal of this research was to provide a programmatic solution that increases the power generation capabilities of the ISS in orbits experiencing Earth-eclipse without requiring any physical modifications to the space station's structure. To achieve this goal, a simulator was developed to model the ISS-Earth-Sun environment and calculate the power output of the station's solar arrays based on each panel's orientation and shadowing. Many combinations of array configurations were analyzed, taking into account the physical constraints of the gimbals responsible for rotating the solar panels. The power output of the ISS was improved for the subset of Earth-eclipsed orbits that experience a high degree of shadowing from the station's structure, resulting in an average energy increase of 1.08 kWh per orbit. The power gains were achieved by quickly rotating the solar arrays through the points in each orbit that experienced the highest degree of shadowing.

  8. Effects of a clean coal-fired power generating station on four common Wisconsin lichen species

    SciTech Connect

    Will-Wolf, S.

    1980-01-01

    Algal plasmolysis percentages and other morphological characteristics of Parmelia bolliana Muell. Arg., P. caperata (L.) Ach., P. rudecta Ach., and Physcia millegrana Degel. were compared for specimens growing near to and far from a rural coal-fired generating station in south central Wisconsin. SO/sup 2/ levels were 389 ..mu..g/m/sup 3/, maximum 1 hr level, and 5-9 ..mu..g/m/sup 3/, annual averages. Parmelia bolliana and P. caperata showed evidence of morphological alterations near the station; P. rudecta and Physcia millegrana did not.

  9. Radwaste (DAW) volume reduction cost initiative at the Oyster Creek Nuclear Generation Station

    SciTech Connect

    Wacha, A.H.

    1995-05-01

    Oyster Creek Nuclear Generating Station is a General Electric Mark 1, 620 MWe (Net) Boiling Water Reactor operated by GPU Nuclear Corporation and located in Forked River, New Jersey. The plant began commercial operation on December 23, 1969, and achieved its longest continuous run during cycle 14 (413 days) 2-16-93 to 9-11-94. As part of the industry-wide initiative to reduce nuclear plant O&M costs, the Electric Power Research Institute (EPRI) was asked by GPU Nuclear to assist the Oyster Creek Nuclear Generating Station (OCNGS) in identifying opportunities for reducing the costs associated with its Radwaste Minimization Program for Dry Active Waste (DAW). The purpose of the project was to evaluate the existing generation, minimization, processing and disposal programs and to identify a wide variety of potential mechanisms for reducing waste volumes and associated costs.

  10. On the possibility of generation of cold and additional electric energy at thermal power stations

    NASA Astrophysics Data System (ADS)

    Klimenko, A. V.; Agababov, V. S.; Borisova, P. N.

    2017-06-01

    A layout of a cogeneration plant for centralized supply of the users with electricity and cold (ECCG plant) is presented. The basic components of the plant are an expander-generator unit (EGU) and a vapor-compression thermotransformer (VCTT). At the natural-gas-pressure-reducing stations, viz., gas-distribution stations and gas-control units, the plant is connected in parallel to a throttler and replaces the latter completely or partially. The plant operates using only the energy of the natural gas flow without burning the gas; therefore, it can be classified as a fuelless installation. The authors compare the thermodynamic efficiencies of a centralized cold supply system based on the proposed plant integrated into the thermal power station scheme and a decentralized cold supply system in which the cold is generated by electrically driven vapor-compression thermotransformers installed on the user's premises. To perform comparative analysis, the exergy efficiency was taken as the criterion since in one of the systems under investigation the electricity and the cold are generated, which are energies of different kinds. It is shown that the thermodynamic efficiency of the power supply using the proposed plant proves to be higher within the entire range of the parameters under consideration. The article presents the results of investigating the impact of the gas heating temperature upstream from the expander on the electric power of the plant, its total cooling capacity, and the cooling capacities of the heat exchangers installed downstream from the EGU and the evaporator of the VCTT. The results of calculations are discussed that show that the cold generated at the gas-control unit of a powerful thermal power station can be used for the centralized supply of the cold to the ventilation and conditioning systems of both the buildings of the power station and the neighboring dwelling houses, schools, and public facilities during the summer season.

  11. 33 CFR 165.552 - Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey. 165.552 Section 165.552 Navigation and Navigable... Coast Guard District § 165.552 Security Zone; Oyster Creek Generation Station, Forked River, Ocean...

  12. 33 CFR 165.552 - Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey. 165.552 Section 165.552 Navigation and Navigable... Coast Guard District § 165.552 Security Zone; Oyster Creek Generation Station, Forked River, Ocean...

  13. 33 CFR 165.552 - Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey. 165.552 Section 165.552 Navigation and Navigable... Coast Guard District § 165.552 Security Zone; Oyster Creek Generation Station, Forked River, Ocean...

  14. 33 CFR 165.552 - Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey. 165.552 Section 165.552 Navigation and Navigable... Coast Guard District § 165.552 Security Zone; Oyster Creek Generation Station, Forked River, Ocean...

  15. 33 CFR 165.552 - Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; Oyster Creek Generation Station, Forked River, Ocean County, New Jersey. 165.552 Section 165.552 Navigation and Navigable... Coast Guard District § 165.552 Security Zone; Oyster Creek Generation Station, Forked River, Ocean...

  16. 77 FR 49463 - Southern California Edison, San Onofre Nuclear Generating Station, Units 2 and 3; Application and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Southern California Edison, San Onofre Nuclear Generating Station, Units 2 and 3; Application and... Edison Company (SCE, the licensee) for operation of the San Onofre Nuclear Generating Station...

  17. 76 FR 40944 - PSEG Nuclear, LLC, Salem Nuclear Generating Station, Units 1 and 2; Notice of Issuance of Renewed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... COMMISSION PSEG Nuclear, LLC, Salem Nuclear Generating Station, Units 1 and 2; Notice of Issuance of Renewed... License Nos. DPR-70 and DPR-75 to PSEG Nuclear LLC (the licensee), the operator of the Salem Nuclear Generating Station, Units 1 and 2 (Salem). Renewed Facility Operating License Nos. DPR-70 and DPR-75...

  18. 76 FR 24064 - Arizona Public Service Company, Palo Verde Nuclear Generating Station, Units 1, 2, and 3, Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... COMMISSION [Docket Nos. 50-528, 50-529, 50-530; NRC-2009-0012 Arizona Public Service Company, Palo Verde... of the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (PVNGS). Renewed Facility Operating... Palo Verde Nuclear Generating Station,'' issued January 2011, discusses the Commission's...

  19. 75 FR 8149 - Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... COMMISSION Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3... Verde Nuclear Generating Station (PVNGS, the facility), Units 1, 2, and 3, respectively, located in... different resources than those previously considered in the Final Environmental Statement for the Palo...

  20. Confirmatory Survey Results for the Reactor Building Dome Upper Surfaces, Rancho Saco Nuclear Generating Station

    SciTech Connect

    Wade C. Adams

    2006-10-25

    Results from a confirmatory survey of the upper structural surfaces of the Reactor Building Dome at the Rancho Seco Nuclear Generating Station (RSNGS) performed by the Oak Ridge Institute for Science and Education for the NRC. Also includes results of interlaboratory comparison analyses on several archived soil samples that would be provided by RSNGS personnel. The confirmatory surveys were performed on June 7 and 8, 2006.

  1. Teamwork and technology cope with environmental challenges - environmental compatibility of a major coal fired generating station

    SciTech Connect

    Smith, W.B.

    1996-12-31

    This paper reviews the environmental successes of the SCE&G Cope Station Unit 1, a 385 MW coal fired generating station placed into operation in January, 1996. Teamwork of the owner, South Carolina Electric & Gas Company (SCE&G) and Duke/Fluor Daniel (DFD), the engineer-constructor for the project, resulted in the successful permitting of the 3200 acre site in lower South Carolina for the construction of three generating units totaling 1200 MW. The site is located amid significant wetland areas adjacent to an environmentally significant black water resource, the South Fork Edisto River. SCE&G and D/FD signed the contract for engineering, procurement, and construction of the Cope Generating Station Unit 1 in June of 1991. At the time of contract finalization environmental studies and preparation of an environmental assessment (EA) for the project had been well underway for over 12 months. The environmental assessment began with field studies to perform air monitoring, water quality sampling and biological research. The EA was prepared by an interdisciplinary team from D/FD, including engineers involved in the conceptual design of the plant. The implementation of this interdisciplinary teaming approach resulted in valuable environmental sensitivity which was manifested throughout design and execution of the project.

  2. Radioiodine treatment in McCune-Albright syndrome with hyperthyroidism.

    PubMed

    Chakraborty, Dhritiman; Mittal, Bhagwant Rai; Kashyap, Raghava; Manohar, Kuruva; Bhattacharya, Anish; Bhansali, Anil

    2012-07-01

    McCune-Albright syndrome (MAS) is a sporadic disease characterized by polyostotic fibrous dysplasia, "café-au-lait" spots and hyperfunctional endocrinopathies. Pathophysiological basis is activating mutation of the gene that encodes the alpha subunit of Gs membrane protein that stimulates the intracellular production of cAMP, conferring autonomous secretion of the gland in particular. One of the uncommon endocrine manifestations is hyperthyroidism. We present a patient who had café-au-lait spots, polyostotic fibrous dysplasia and hyperthyroidism. She was treated with radioactive iodine for the symptoms of hyperthyroidism and subsequently relieved from hyperthyroid features.

  3. McCune-Albright syndrome: radiological and MR findings.

    PubMed

    Yongjing, G; Huawei, L; Zilai, P; Bei, D; Hao, J; Kemin, C

    2001-01-01

    McCune-Albright syndrome (MAS) is a non-inherited disorder due to the GNAS1 gene mutation. The syndrome is characterized with the triad of polyostotic fibrous dysplasia, pigmented skin lesions, endocrinopathy, and precocious puberty. We report the case of a 14-year-old boy, presenting with sclerotic type of polyostotic fibrous dysplasia. Radiological methods including plain X-ray film, MR and whole body bone scintigraphy suggested the diagnosis of MAS. MRI provided more directly perceived images and it was more sensitive in demonstrating the lesion: its shape, contents, especially the size of the affected region. Histopathological study and the identification of mutant gene finally confirmed the diagnostic result.

  4. Acrogigantism and facial asymmetry: McCune-Albright syndrome.

    PubMed

    Subbiah, Sridhar; Palikhe, Gaurav; Bhadada, Sanjay Kumar; Mukherjee, Kanchan Kumar; Bhansali, Anil

    2011-01-01

    McCune-Albright syndrome (MAS) is characterized by a triad of poly/monoostotic fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies. Association of MAS with GH excess is rare, and in most of the instances somatotropinoma has not been documented. Treatment of patients of MAS with acromegaly is difficult because of thickened calvarium and dysplastic skull bone. We report a 17-year-old girl, who presented with cranio-facial fibrous dysplasia, café-au-lait macules and also had acromegaly due to pituitary macroadenoma, and treated with gamma knife radiosurgery.

  5. Solar voltaic generator requirements for large-scale central-station

    NASA Astrophysics Data System (ADS)

    Canada, A. H.

    A solar voltaic generation (SVG) reference system is examined in terms of engineering and manufacturing requirements and solar voltaic generator characteristics. The SVG system proposed here is composed of four subsystems chosen to conform to existing sectors of the utility engineering and manufacturing industry and the emerging SVG unit supply industry. The four subsystems are: the SVG subsystem, the transmission and station structure system, the power apparatus subsystem, and the monitoring and control subsystem. The material and engineering requirements for the SVG reference system are compared with those for a typical nuclear power plant.

  6. Models for the transient stability of conventional power generating stations connected to low inertia systems

    NASA Astrophysics Data System (ADS)

    Zarifakis, Marios; Coffey, William T.; Kalmykov, Yuri P.; Titov, Sergei V.

    2017-06-01

    An ever-increasing requirement to integrate greater amounts of electrical energy from renewable sources especially from wind turbines and solar photo-voltaic installations exists and recent experience in the island of Ireland demonstrates that this requirement influences the behaviour of conventional generating stations. One observation is the change in the electrical power output of synchronous generators following a transient disturbance especially their oscillatory behaviour accompanied by similar oscillatory behaviour of the grid frequency, both becoming more pronounced with reducing grid inertia. This behaviour cannot be reproduced with existing mathematical models indicating that an understanding of the behaviour of synchronous generators, subjected to various disturbances especially in a system with low inertia requires a new modelling technique. Thus two models of a generating station based on a double pendulum described by a system of coupled nonlinear differential equations and suitable for analysis of its stability corresponding to infinite or finite grid inertia are presented. Formal analytic solutions of the equations of motion are given and compared with numerical solutions. In particular the new finite grid model will allow one to identify limitations to the operational range of the synchronous generators used in conventional power generation and also to identify limits, such as the allowable Rate of Change of Frequency which is currently set to ± 0.5 Hz/s and is a major factor in describing the volatility of a grid as well as identifying requirements to the total inertia necessary, which is currently provided by conventional power generators only, thus allowing one to maximise the usage of grid connected non-synchronous generators, e.g., wind turbines and solar photo-voltaic installations.

  7. A practical design for an integrated HVDC unit - connected hydro-electric generating station

    SciTech Connect

    Ingram, L. )

    1988-10-01

    To date, several authors (see reference list) have proclaimed benefits which can be achieved by integrating HVDC converter stations directly with generating units. The cost of a significant amount of plant and facilities found in conventional schemes is thereby eliminated. So far as is known however, no detailed studies have been done to quantify these benefits. This paper outlines the results of a study made recently by the Manitoba HVDC Research Centre to determine the practicality of such a scheme. To give credence to the results an actual hydro station design was used incorporating a HVDC thyristor valve scheme in a hypothetical situation. Financial and other benefits were determined for this example together with conclusions and recommendations for future specific projects and further areas of study.

  8. 76 FR 25378 - Exelon Generation Company, LLC; PSEG Nuclear, LLC; Peach Bottom Atomic Power Station, Units 2 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Exelon Generation Company, LLC; PSEG Nuclear, LLC; Peach Bottom Atomic Power Station, Units 2 and... Nos. DPR-44 and DPR-56 for the Peach Bottom Atomic Power Station (PBAPS), Units 2 and 3, located in...

  9. 75 FR 6071 - Exelon Generation Company, LLC; PSEG Nuclear, LLC; Peach Bottom Atomic Power Station Units 2 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Exelon Generation Company, LLC; PSEG Nuclear, LLC; Peach Bottom Atomic Power Station Units 2 and 3... Operating License Nos. DPR-44 and DPR-56 for the Peach Bottom Atomic Power Station (PBAPS), Units 2 and 3...

  10. Using the International Space Station (ISS) Oxygen Generation Assembly (OGA) Is Not Feasible for Mars Transit

    NASA Technical Reports Server (NTRS)

    Jones, Harry W.

    2016-01-01

    A review of two papers on improving the International Space Station (ISS) Oxygen Generation Assembly (OGA) shows that it would not save substantial mass on a Mars transit. The ISS OGA requires redesign for satisfactory operation, even for the ISS. The planned improvements of the OGA for ISS would not be sufficient to make it suitable for Mars, because Mars transit life support has significantly different requirements than ISS. The OGA for Mars should have lower mass, better reliability and maintainability, greater safety, radiation hardening, and capability for quiescent operation. NASA's methodical, disciplined systems engineering process should be used to develop the appropriate system.

  11. Safety research of insulating materials of cable for nuclear power generating station

    NASA Technical Reports Server (NTRS)

    Lee, C. K.; Choi, J. H.; Kong, Y. K.; Chang, H. S.

    1988-01-01

    The polymers PE, EPR, PVC, Neoprene, CSP, CLPE, EP and other similar substances are frequently used as insulation and protective covering for cables used in nuclear power generating stations. In order to test these materials for flame retardation, environmental resistance, and cable specifications, they were given the cable normal test, flame test, chemical tests, and subjected to design analysis and loss of coolant accident tests. Material was collected on spark tests and actual experience standards were established through these contributions and technology was accumulated.

  12. Zooplankton of the waters adjacent to the C. P. Crane generating station. Final report

    SciTech Connect

    Grant, G.C.; Womack, C.J.; Olney, J.E.

    1980-08-01

    Zooplankton population in the Gunpowder River and its tributaries were sampled monthly from July, 1979-March, 1980 in a continuation of similar studies begun in March, 1979. The objective of the study was to determine the effect of the present once-through cooling system of the Crane Power Plant. The principal effect of the C.P. Crane generating station on zooplankton of the area is a displacement of an original freshwater community through the pumping of cooling water from Seneca Creek to Saltpeter Creek.

  13. Solar repowering for electric generation. Northeastern Station Unit 1, Public Service Company of Oklahoma. Final report

    SciTech Connect

    Not Available

    1980-07-15

    The conceptual design and evaluation of solar repowering and electric generating unit of Public Service Company of Oklahoma (PSO) are described in detail. The solar addition would permit, at the design point, a 20% reduction of the fossil fuel consumed by PSO's 150 MWe Northeastern Station Unit 1. The proposed system comprises a tower focus power plant with a water/steam central receiver. This volume presents the trade studies, conceptual design, system performance, economic analysis, and development plan as well as a description of a test program to determine the magnitude of impact that environmental factors have on plant design and performance. (WHK)

  14. Safety research of insulating materials of cable for nuclear power generating station

    NASA Technical Reports Server (NTRS)

    Lee, C. K.; Choi, J. H.; Kong, Y. K.; Chang, H. S.

    1988-01-01

    The polymers PE, EPR, PVC, Neoprene, CSP, CLPE, EP and other similar substances are frequently used as insulation and protective covering for cables used in nuclear power generating stations. In order to test these materials for flame retardation, environmental resistance, and cable specifications, they were given the cable normal test, flame test, chemical tests, and subjected to design analysis and loss of coolant accident tests. Material was collected on spark tests and actual experience standards were established through these contributions and technology was accumulated.

  15. McCune-Albright syndrome presenting with unilateral macroorchidism and bilateral testicular masses.

    PubMed

    Khanna, Geetika; Kantawala, Kartikeya; Shinawi, Marwan; Sarwate, Sandhya; Dehner, Louis P

    2010-12-01

    Bilateral synchronous intratesticular masses are rare but can be caused by metastatic disease to the testicle, primary testicular masses or benign etiologies such as congenital adrenal hyperplasia and granulomatous orchitis. We present an unusual case of McCune-Albright syndrome presenting with unilateral testicular enlargement and bilateral testicular masses secondary to Sertoli cell hyperplasia. To our knowledge, this is a unique case of testicular masses secondary to McCune-Albright syndrome.

  16. 78 FR 27260 - Southern California Edison, San Onofre Nuclear Generating Station, Units 2 and 3 Request for Action

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Southern California Edison, San Onofre Nuclear Generating Station, Units 2 and 3 Request for... Southern California Edison (SCE) to ] submit a license amendment application for the design...

  17. Status of the International Space Station Regenerative ECLSS Water Recovery and Oxygen Generation Systems

    NASA Technical Reports Server (NTRS)

    Bagdigian, Robert M.; Cloud, Dale

    2005-01-01

    NASA is developing three racks containing regenerative water recovery and oxygen generation systems (WRS and OGS) for deployment on the International Space Station (ISS). The major assemblies included in these racks are the Water Processor Assembly (WPA), Urine Processor Assembly (UPA), Oxygen Generation Assembly (OGA), and the Power Supply Module (PSM) supporting the OGA. The WPA and OGA are provided by Hamilton Sundstrand Space Systems International (HSSSI), Inc., while the UPA and PSM are developed in- house by the Marshall Space Flight Center (MSFC). The assemblies have completed the manufacturing phase and are in various stages of testing and integration into the flight racks. This paper summarizes the status as of April 2005 and describes some of the technical challenges encountered and lessons learned over the past year.

  18. Solid polymer electrolyte water electrolysis system development. [to generate oxygen for manned space station applications

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Solid polymer electrolyte technology used in a water electrolysis system (WES) to generate oxygen and hydrogen for manned space station applications was investigated. A four-man rated, low pressure breadboard water electrolysis system with the necessary instrumentation and controls was fabricated and tested. A six man rated, high pressure, high temperature, advanced preprototype WES was developed. This configuration included the design and development of an advanced water electrolysis module, capable of operation at 400 psig and 200 F, and a dynamic phase separator/pump in place of a passive phase separator design. Evaluation of this system demonstrated the goal of safe, unattended automated operation at high pressure and high temperature with an accumulated gas generation time of over 1000 hours.

  19. Simulator verification effort at the South Texas project electric generating station

    SciTech Connect

    Bellmore, P.E.; Albury, C.R.

    1987-01-01

    This paper presents the work being done at Houston Lighting and Power Company to verify the South Texas Project Electric Generating Station (STPEGS) simulator. The purpose of that work is to assure that the STPEGS simulator adequately reflects plant response during normal and abnormal transients. An enhanced understanding of the engineering and organizational needs of a simulator verification program is significant. This paper presents the techniques used to develop a best-estimate model. The best-estimate model generates plant response data for comparison with the STPEGS simulator. A typical licensing model is inadequate for this work because of the conservative assumptions in the model. The authors examine, in this paper, the interaction between the various groups responsible for simulator verification.

  20. A collaborative effort to apply ergonomics to electric utility workers at generating stations.

    PubMed

    Stone, Amy; Marklin, Richard; Seeley, Patricia; Mezei, Gabor

    2011-01-01

    As part of a collaborative approach involving electric utility companies, university researchers, individual contractors and a not-for-profit research institute, two ergonomics teams consisting of skilled utility workers and trained ergonomists, were assembled. These teams were to identify tasks with risk factors for musculoskeletal disorders (MSDs) among workers in fossil-fueled generating stations and and to propose ergonomic interventions for these tasks. One team focused on tasks of electricians and the other focused on tasks of plant operators and mechanics. Several of the tasks were tested in an ergonomics laboratory and at one of the utility's generating stations. We present a sample of the recommended interventions in this paper. An anthropometric analysis of electrical box height recommended the appropriate height for electrical boxes. The results of a field experiment showed that low rolling resistance wheels decreased the forces to initiate and sustain pushing a cart. The same experiment also demonstrated that the forces required to turn a cart with six wheels were lower than the forces equired to turn a cart with four wheels. A collaborative approach to ergonomics proved to be an effective method to identify and assess tasks that are problematic for workers and to develop best practices for these tasks in the electric power industry. This method could be used by other industries in their attempt to decrease the incidence, cost and severity of workplace MSDs. © 2011 - IOS Press and the authors. All rights reserved

  1. Environmental radiological studies in 1989 near the Rancho Seco Nuclear Power Generating Station

    SciTech Connect

    Robison, W.L.; Wong, Kai M.; Jones, H.E.

    1990-11-01

    In December 1988, the Sacramento Municipal Utilities District (SMUD) asked the Lawrence Livermore National Laboratory's (LLNL) Environmental Sciences Division (ENV) to collect sediment, water,and fish samples downstream from the Rancho Seco Nuclear Power Generating Station for analysis of radionuclides to compare with results from earlier surveys in 1984 through 1987 (1--8). ENV was, however, asked to reduce the total number of sample collections to a minimum in this study because of financial constraints. The proposal ENV submitted for the 1989 Environmental Radiological Studies downstream of the Rancho Seco Nuclear Power Generating Station reflected this reduction, but we believe, nevertheless, the 1989 efforts do allow us to make some meaningful comparisons with the previous studies. Cesium-137 is the most significant radionuclide still observed downstream from the Rancho Seco Nuclear Power Plant. Only occasionally is {sup 134}Cs or {sup 60}CO observed. In 1989, the concentration of {sup 137}Cs in the water and fish decreased with distance from the plant to the same level that is was in 1987, and was lower than it had been from 1984 through 1986. The concentration ratio (CR) for {sup 137}Cs in fish is between 1000 and 1500, which is below the NRC default value of 2000. Physical mixing in the creek environment has moved the {sup 137}Cs deeper into the sediment column, thereby reducing the concentration in the top 12 cm relative to that in previous years. 8 refs., 18 figs., 9 tabs.

  2. Development of an HTS hydroelectric power generator for the hirschaid power station

    NASA Astrophysics Data System (ADS)

    Fair, Ruben; Lewis, Clive; Eugene, Joseph; Ingles, Martin

    2010-06-01

    This paper describes the development and manufacture of a 1.7MW, 5.25kV, 28pole, 214rpm hydroelectric power generator consisting of superconducting HTS field coils and a conventional stator. The generator is to be installed at a hydro power station in Hirschaid, Germany and is intended to be a technology demonstrator for the practical application of superconducting technology for sustainable and renewable power generation. The generator is intended to replace and uprate an existing conventional generator and will be connected directly to the German grid. The HTS field winding uses Bi-2223 tape conductor cooled to about 30K using high pressure helium gas which is transferred from static cryocoolers to the rotor via a bespoke rotating coupling. The coils are insulated with multi-layer insulation and positioned over laminated iron rotor poles which are at room temperature. The rotor is enclosed within a vacuum chamber and the complete assembly rotates at 214rpm. The challenges have been significant but have allowed Converteam to develop key technology building blocks which can be applied to future HTS related projects. The design challenges, electromagnetic, mechanical and thermal tests and results are presented and discussed together with applied solutions.

  3. Image diagnosis in McCune-Albright syndrome.

    PubMed

    Defilippi, Claudio; Chiappetta, Domenico; Marzari, Daniela; Mussa, Alessandro; Lala, Roberto

    2006-05-01

    McCune-Albright syndrome consists of polyostotic fibrous dysplasia, precocious puberty and cafè-au-lait skin lesions. Bone lesions are characterized by the presence of fibrous connective tissue with a characteristic whorled pattern and containing trabeculae of immature non-lamellar (woven) bone. They may be solitary (monostotic) or multiple (polyostotic). Commonly involved bones include the femur, tibia, ribs and facial skeleton. In the fibula pseudo-cystic areas and 'ground glass'-like areas, in the femur 'shepherd crook' deformation due to weight on a less resistant bone and secondary to many cortical microfractures, are typical. MRI gives the exact delimitation of the lesions and is especially indicated in the followup of monostotic forms and in the outcome of surgical corrections. Bone scintigraphy with technetium 99 is essential in the follow-up of the disease. Ultrasonography is very useful in ovarian cyst follow-up and in the detection of thyroid and adrenal nodules and testicular microlithiasis.

  4. The Satellite Nuclear Power Station - An option for future power generation.

    NASA Technical Reports Server (NTRS)

    Williams, J. R.; Clement, J. D.

    1973-01-01

    A new concept in nuclear power generation is being explored which essentially eliminates major objections to nuclear power. The Satellite Nuclear Power Station, remotely operated in synchronous orbit, would transmit power safely to the ground by a microwave beam. Fuel reprocessing would take place in space and no radioactive materials would ever be returned to earth. Even the worst possible accident to such a plant should have negligible effect on the earth. An exploratory study of a satellite nuclear power station to provide 10,000 MWe to the earth has shown that the system could weigh about 20 million pounds and cost less than $1000/KWe. An advanced breeder reactor operating with an MHD power cycle could achieve an efficiency of about 50% with a 1100 K radiator temperature. If a hydrogen moderated gas core reactor is used, its breeding ratio of 1.10 would result in a fuel doubling time of a few years. A rotating fluidized bed or NERVA type reactor might also be used. The efficiency of power transmission from synchronous orbit would range from 70% to 80%.

  5. The Satellite Nuclear Power Station - An option for future power generation.

    NASA Technical Reports Server (NTRS)

    Williams, J. R.; Clement, J. D.

    1973-01-01

    A new concept in nuclear power generation is being explored which essentially eliminates major objections to nuclear power. The Satellite Nuclear Power Station, remotely operated in synchronous orbit, would transmit power safely to the ground by a microwave beam. Fuel reprocessing would take place in space and no radioactive materials would ever be returned to earth. Even the worst possible accident to such a plant should have negligible effect on the earth. An exploratory study of a satellite nuclear power station to provide 10,000 MWe to the earth has shown that the system could weigh about 20 million pounds and cost less than $1000/KWe. An advanced breeder reactor operating with an MHD power cycle could achieve an efficiency of about 50% with a 1100 K radiator temperature. If a hydrogen moderated gas core reactor is used, its breeding ratio of 1.10 would result in a fuel doubling time of a few years. A rotating fluidized bed or NERVA type reactor might also be used. The efficiency of power transmission from synchronous orbit would range from 70% to 80%.

  6. International Space Station United States Orbital Segment Oxygen Generation System On-Orbit Operational Experience

    NASA Technical Reports Server (NTRS)

    Erickson, Robert J.; Howe, John, Jr.; Kulp, Galen W.; VanKeuren, Steven P.

    2008-01-01

    The International Space Station (ISS) United States Orbital Segment (USOS) Oxygen Generation System (OGS) was originally intended to be installed in ISS Node 3. The OGS rack delivery was accelerated, and it was launched to ISS in July of 2006 and installed in the US Laboratory Module. Various modification kits were installed to provide its interfaces, and the OGS was first activated in July of 2007 for 15 hours, In October of 2007 it was again activated for 76 hours with varied production rates and day/night cycling. Operational time in each instance was limited by the quantity of feedwater in a Payload Water Reservoir (PWR) bag. Feedwater will be provided by PWR bag until the USOS Water Recovery System (WRS) is delivered to SS in fall of 2008. This paper will discuss operating experience and characteristics of the OGS, as well as operational issues and their resolution.

  7. 33 CFR 165.553 - Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey. 165.553 Section 165.553 Navigation... Limited Access Areas Fifth Coast Guard District § 165.553 Security Zone; Salem and Hope Creek Generation...

  8. 33 CFR 165.553 - Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey. 165.553 Section 165.553 Navigation... Limited Access Areas Fifth Coast Guard District § 165.553 Security Zone; Salem and Hope Creek Generation...

  9. 33 CFR 165.553 - Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey. 165.553 Section 165.553 Navigation... Limited Access Areas Fifth Coast Guard District § 165.553 Security Zone; Salem and Hope Creek Generation...

  10. 33 CFR 165.553 - Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey. 165.553 Section 165.553 Navigation... Limited Access Areas Fifth Coast Guard District § 165.553 Security Zone; Salem and Hope Creek Generation...

  11. 33 CFR 165.553 - Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; Salem and Hope Creek Generation Stations, Delaware River, Salem County, New Jersey. 165.553 Section 165.553 Navigation... Limited Access Areas Fifth Coast Guard District § 165.553 Security Zone; Salem and Hope Creek Generation...

  12. Environmental radiological studies downstream from Rancho Seco Nuclear Power Generating Station

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Dawson, J.W.; Brunk, J.L.; Jokela, T.A.

    1985-03-22

    This report summarizes the information compiled in 1984 while assessing the environmental impact of radionuclides in aquatic releases from the Rancho Seco Nuclear Power Generating Station. Gamma-emitting radionuclides discharged since 1981 are found in many of the dietary components derived from the creeks receiving the effluent wastewater. Some soils and crops are found to contain radionuclides that originate from the contaminated water that was transferred to land during the irrigation season. /sup 134/Cs and /sup 137/Cs are the primary gamma-emitting radionuclides detected in the edible flesh of fish from the creeks. Concentrations in the flesh of fish decreased exponentially with distance from the plant. No significant differences in the /sup 137/Cs activity were found between male and female fish of equal size, but concentrations may vary in fish of different size, with the season and diet. 21% of the total /sup 137/Cs and /sup 134/Cs discharged between 1981 and 1984 is associated with the creek sediments to a distance of 27 km from the plant. Fractions of the missing inventory have been transferred to land during the irrigation season or to downstream regions more distant than 27 km from the plant. The radiocesium content of the sediments in 1984 decreased significantly in a downstream direction, much in the same manner as concentrations decreased in fish. Radioactivity originating from the plant was not above detection limits in any terrestrial food item sampled beyond 6.5 km from the plant. Based on the usage factors provided by individuals interviewed in a 1984 survey, the fish and aquatic-organism ingestion pathway contributed the largest radiological dose to humans utilizing products contaminated with the radionuclides in the liquid wastes discharged from the Rancho Seco Nuclear Power Generating Station in 1984.

  13. Development of the Second Generation International Space Station (ISS) Total Organic Carbon Analyzer (TOCA)

    NASA Technical Reports Server (NTRS)

    Clements, Anna L.; Stinson, Richard G.; VanWie, Michael; Warren, Eric

    2009-01-01

    The second generation International Space Station (ISS) Total Organic Carbon Analyzer s (TOCA) function is to monitor concentrations of Total Organic Carbon (TOC) in ISS water samples. TOC is one measurement that provides a general indication of overall water quality by indicating the potential presence of hazardous chemicals. The data generated from the TOCA is used as a hazard control to assess the quality of the reclaimed and stored water supplies on-orbit and their suitability for crew consumption. This paper details the unique ISS Program requirements, the design of the ISS TOCA, and a brief description of the on-orbit concept-of-operations. The TOCA schematic will be discussed in detail along with specific information regarding key components. The ISS TOCA was designed as a non-toxic TOC analyzer that could be deployed in a flight ready package. This basic concept was developed through laboratory component level testing, two moderate fidelity integrated system breadboard prototypes, a flight-like full scale prototype, as well as lessons learned from the inadequacies of the first unit. The result: a new TOCA unit that is robust in design and includes special considerations to microgravity and the on-orbit ISS environment. TOCA meets the accuracy needs of the ISS Program with a 1,000 to 25,000 g/L range, accurate to within +/-25%.

  14. Development of the Next Generation Gas Trap for the Space Station Internal Thermal Control System

    NASA Technical Reports Server (NTRS)

    Leimkuehler, Thomas O.; Spelbring, Chris; Reeves, Daniel R.; Holt, James M.

    2003-01-01

    The current dual-membrane gas trap is designed to remove non-condensed gases (NCG) from the Internal Thermal Control System (ITCS) coolant on board the International Space Station (ISS). To date it has successfully served its purpose of preventing depriming, overspeed, and shutdown of the ITCS pump. However, contamination in the ITCS coolant has adversely affected the gas venting rate and lifetime of the gas trap, warranting a development effort for a next-generation gas trap. Design goals are to meet or exceed the current requirements to (1) include greater operating ranges and conditions, (2) eliminate reliance on the current hydrophilic tube fabrication process, and (3) increase operational life and tolerance to particulate and microbial growth fouling. In addition, the next generation gas trap will essentially be a 'dropin" design such that no modifications to the ITCS pump package assembly (PPA) will be required, and the implementation of the new design will not affect changes to the ITCS operational conditions, interfaces, or software. This paper will present the initial membrane module design and development work which has included (1) a trade study among several conceptual designs, (2) performance modeling of a hydrophobic-only design, and (3) small-scale development test data for the hydrophobic-only design. Testing has shown that the hydrophobic-only design is capable of performing even better than the current dual-membrane design for both steady-state gas removal and gas slug removal.

  15. Development of the Next Generation Gas Trap for the Space Station Internal Thermal Control System

    NASA Technical Reports Server (NTRS)

    Leimkuehler, Thomas O.; Spelbring, Chris; Reeves, Daniel R.; Holt, James M.

    2003-01-01

    The current dual-membrane gas trap is designed to remove non-condensed gases (NCG) from the Internal Thermal Control System (ITCS) coolant on board the International Space Station (ISS). To date it has successfully served its purpose of preventing depriming, overspeed, and shutdown of the ITCS pump. However, contamination in the ITCS coolant has adversely affected the gas venting rate and lifetime of the gas trap, warranting a development effort for a next-generation gas trap. Design goals are to meet or exceed the current requirements to (1) include greater operating ranges and conditions, (2) eliminate reliance on the current hydrophilic tube fabrication process, and (3) increase operational life and tolerance to particulate and microbial growth fouling. In addition, the next generation gas trap will essentially be a 'dropin" design such that no modifications to the ITCS pump package assembly (PPA) will be required, and the implementation of the new design will not affect changes to the ITCS operational conditions, interfaces, or software. This paper will present the initial membrane module design and development work which has included (1) a trade study among several conceptual designs, (2) performance modeling of a hydrophobic-only design, and (3) small-scale development test data for the hydrophobic-only design. Testing has shown that the hydrophobic-only design is capable of performing even better than the current dual-membrane design for both steady-state gas removal and gas slug removal.

  16. Solar repowering for electric generation. Northeastern Station Unit 1, Public Service Company of Oklahoma

    SciTech Connect

    Not Available

    1980-07-15

    The Department of Energy contracted for Black and Veatch to develop a conceptual design for solar repowering Northeastern Station Unit 1 (NES 1) of the Public Service Company of Oklahoma (PSO). NES 1 is located about 50 km (30 miles) northeast of Tulsa, Oklahoma. This plant was selected because it is representative of candidate plants for repowering and for solar-fossil hybrid operation; it is located in a moderate insolation region, utilizes an efficient reheat cycle with steam conditions characteristic of modern power plants, and has sufficient land for repowering. NES 1 has a subcritical, single reheat turbine-generator and a gas-fired steam generator. The basic repowering configuration was established through a series of trade studies and the criterion that proven technology be used. The system selected has a water/steam receiver which supplies superheated steam to the turbine at a design point flow rate sufficient to displace 20 percent of the unit's fossil fuel consumption. This volume contains the appendices: (A) system requirements specification, and (B) daily insolation profiles. (WHK)

  17. Solar repowering for electric generation: Northeastern Station Unit 1, Public Service Company of Oklahoma. Executive summary

    SciTech Connect

    Not Available

    1980-07-15

    The Department of Energy contracted for Black and Veatch to develop a conceptual design for solar repowering Northeastern Station Unit 1 (NES 1) of the Public Service Company of Oklahoma (PSO). NES 1 is located about 50 km (30 miles) northeast of Tulsa, Oklahoma. This plant was selected because it is representative of candidate plants for repowering and for solar-fossil hybrid operation; it is located in a moderate insolation region, utilizes an efficient reheat cycle with steam conditions characteristic of modern power plants, and has sufficient land for repowering. NES 1 has a subcritical, single reheat turbine-generator and a gas-fired steam generator. The basic repowering configuration was established through a series of trade studies and the criterion that proven technology be used. The system selected has a water/steam receiver which supplies superheated steam to the turbine at a design point flow rate sufficient to displace 20 per cent of the unit's fossil fuel consumption. The hybrid nature of the plant's operation eliminates the need for costly thermal storage. A brief overview of the design, performance, and economics is given. (WHK)

  18. MELCOR Analysis of Steam Generator Tube Creep Rupture in Station Blackout Severe Accident

    SciTech Connect

    Liao, Y.; Vierow, K.

    2005-12-15

    A pressurized water reactor steam generator tube rupture (SGTR) is of concern because it represents a bypass of the containment for radioactive materials to the environment. In a station blackout accident, tube integrity could be threatened by creep rupture, particularly if cracks are present in the tube walls. Methods are developed herein to improve assessment capabilities for SGTR by using the severe-accident code MELCOR. Best-estimate assumptions based on recent research and computational fluid dynamics calculations are applied in the MELCOR analysis to simulate two-dimensional natural circulation and to determine the relative creep-rupture timing in the reactor coolant pressure boundary components. A new method is developed to estimate the steam generator (SG) hottest tube wall temperature and the tube critical crack size for the SG tubes to fail first. The critical crack size for SG tubes to fail first is estimated to be 20% of the wall thickness larger than by a previous analysis. Sensitivity studies show that the failure sequence would change if some assumptions are modified. In particular, the uncertainty in the countercurrent flow limit model could reverse the failure sequence of the SG tubes and surge line.

  19. Development of the Second Generation International Space Station (ISS) Total Organic Carbon Analyzer (TOCA)

    NASA Technical Reports Server (NTRS)

    Clements, Anna L.; Stinson, Richard G.; VanWie, Michael; Warren, Eric

    2009-01-01

    The second generation International Space Station (ISS) Total Organic Carbon Analyzer s (TOCA) function is to monitor concentrations of Total Organic Carbon (TOC) in ISS water samples. TOC is one measurement that provides a general indication of overall water quality by indicating the potential presence of hazardous chemicals. The data generated from the TOCA is used as a hazard control to assess the quality of the reclaimed and stored water supplies on-orbit and their suitability for crew consumption. This paper details the unique ISS Program requirements, the design of the ISS TOCA, and a brief description of the on-orbit concept-of-operations. The TOCA schematic will be discussed in detail along with specific information regarding key components. The ISS TOCA was designed as a non-toxic TOC analyzer that could be deployed in a flight ready package. This basic concept was developed through laboratory component level testing, two moderate fidelity integrated system breadboard prototypes, a flight-like full scale prototype, as well as lessons learned from the inadequacies of the first unit. The result: a new TOCA unit that is robust in design and includes special considerations to microgravity and the on-orbit ISS environment. TOCA meets the accuracy needs of the ISS Program with a 1,000 to 25,000 g/L range, accurate to within +/-25%.

  20. Osteosarcoma in a pregnant patient with McCune-Albright syndrome.

    PubMed

    Kanazawa, Ippei; Yamauchi, Mika; Yano, Shozo; Imanishi, Yasuo; Kitazawa, Riko; Nariai, Yoshiki; Araki, Asuka; Kobayashi, Keisuke; Inaba, Masaaki; Maruyama, Riruke; Yamaguchi, Toru; Sugimoto, Toshitsugu

    2009-09-01

    Malignant transformation of fibrous dysplasia is very rare and has not been previously described in patients with McCune-Albright syndrome in the absence of radiation treatment during gestation. Here, we report a 38-year-old pregnant woman with McCune-Albright syndrome and acromegaly accompanied by osteosarcoma. The patient was in the 6th week of pregnancy, when she visited our hospital. She had multiple fibrous dysplasia, skin pigmentation, and acromegaly. The markedly high bone turnover rate during pregnancy tended to decrease after a normal delivery. Fibrous dysplasia of the lower jaw rapidly increased in the 37th week of pregnancy, and the tumor was surgically resected after delivery. Pathological examination of the resected tumor revealed fibrous dysplasia admixed with osteosarcoma containing chondroblastic and osteoblastic tissue. We firstly reported a case of osteosarcoma in a patient with McCune-Albright syndrome, which rapidly progressed during pregnancy.

  1. Cushing's syndrome caused by nodular adrenal hyperplasia in children with McCune-Albright syndrome.

    PubMed

    Kirk, J M; Brain, C E; Carson, D J; Hyde, J C; Grant, D B

    1999-06-01

    McCune-Albright syndrome consists of fibrous dysplasia of bone, café-au-lait skin pigmentation, and endocrine dysfunction (usually precocious puberty). Other endocrine abnormalities occur in a minority of patients, and of these, Cushing's syndrome is the least often recognized. We present 5 children (4 girls) with features of McCune-Albright syndrome who had Cushing's syndrome in the infantile period (<6 months). In 2 children spontaneous resolution occurred, but the remaining 3 required bilateral adrenalectomy. In addition, all 4 girls have experienced precocious puberty, and 3 children demonstrated radiologic evidence of nephrocalcinosis. Understanding of the underlying defect causing McCune-Albright syndrome emphasizes the importance of searching for other endocrine dysfunction in these children.

  2. Acromegaly with hypophosphataemia: McCune-Albright syndrome.

    PubMed

    Pal, Rimesh; Dutta, Pinaki; Mukherjee, Kanchan Kumar; Bhansali, Anil

    2017-09-28

    A 38-year-old man presented with excessive height gain and progressive enlargement of the extremities since childhood. This was compounded by lower limb deformities over the past 5 years. On examination, his height was 196 cm, he had macroglossia, acral enlargement, seborrhoea, hyperhidrosis-suggesting acrogigantism. He had facial asymmetry, wind-swept deformity of lower limbs and a café-au-lait macule over his trunk. Investigations revealed normal-sized pituitary gland with dysplastic cranial bones. Isotope bone scintigraphy was suggestive of polyostotic fibrous dysplasia. A diagnosis of McCune-Albright syndrome was made and trans-sphenoidal hypophysectomy was undertaken. He had persistent hypophosphataemia. Tubular reabsorption of phosphate adjusted for glomerular filtration rate was low and serum FGF-23 level was high. Ga-DOTATATE scintigraphy showed somatostatin-receptor expression in all the dysplastic lesions. FGF-23 produced by the bony lesions could counteract the phosphate-retaining effect of GH excess resulting in hypophosphataemia, which further worsened following hypophysectomy. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Navajo Generating Station and Clean-Energy Alternatives: Options for Renewables

    SciTech Connect

    Hurlbut, D. J.; Haase, S.; Turchi, C. S.; Burman, K.

    2012-06-01

    In January 2012, the National Renewable Energy Laboratory delivered to the Department of the Interior the first part of a study on Navajo Generating Station (Navajo GS) and the likely impacts of BART compliance options. That document establishes a comprehensive baseline for the analysis of clean energy alternatives, and their ability to achieve benefits similar to those that Navajo GS currently provides. This analysis is a supplement to NREL's January 2012 study. It provides a high level examination of several clean energy alternatives, based on the previous analysis. Each has particular characteristics affecting its relevance as an alternative to Navajo GS. It is assumed that the development of any alternative resource (or portfolio of resources) to replace all or a portion of Navajo GS would occur at the end of a staged transition plan designed to reduce economic disruption. We assume that replacing the federal government's 24.3% share of Navajo GS would be a cooperative responsibility of both the U.S. Bureau of Reclamation (USBR) and the Central Arizona Water Conservation District (CAWCD).

  4. HT to HTO conversion and field experiments near Darlington Nuclear Power Generating Station (DNPGS) site.

    PubMed

    Kim, S B; Stuart, M; Bredlaw, M; Festarini, A; Beaton, D

    2014-06-01

    The Canadian input parameters related to tritiated hydrogen gas (HT) used in tritium dose models are currently based on experiments performed at the Chalk River Laboratories (CRL) site in 1986, 1987 and 1994. There is uncertainty in how well other sites experiencing atmospheric HT releases are represented by these data. In order to address this uncertainty, HT to HTO conversion factors were evaluated at different locations near the Darlington Nuclear Power Generating Station (DNPGS) site using various experimental approaches. These were D2 gas exposure chamber experiments, atmospheric tritium measurements, and HTO and OBT measurements in vegetation and soil. In addition to these field experiments, chamber experiments were conducted using HT gas on field soil samples. The suggested Canadian input parameters for atmospheric tritium releases estimate the total fraction of HT oxidized in air and in soil, at the site, to be up to a maximum of 2.4%. Based on the more limited data obtained near DNPGS in early spring, this fraction would likely be closer to 0.5%. The result suggests that current parameters provide a conservative estimate for the DNPGS site.

  5. Structural integrity analysis of the degraded drywell containment at the Oyster Creek Nuclear generating station.

    SciTech Connect

    Petti, Jason P.

    2007-01-01

    This study examines the effects of the degradation experienced in the steel drywell containment at the Oyster Creek Nuclear Generating Station. Specifically, the structural integrity of the containment shell is examined in terms of the stress limits using the ASME Boiler and Pressure Vessel (B&PV) Code, Section III, Division I, Subsection NE, and examined in terms of buckling (stability) using the ASME B&PV Code Case N-284. Degradation of the steel containment shell (drywell) at Oyster Creek was first observed during an outage in the mid-1980s. Subsequent inspections discovered reductions in the shell thickness due to corrosion throughout the containment. Specifically, significant corrosion occurred in the sandbed region of the lower sphere. Since the presence of the wet sand provided an environment which supported corrosion, a series of analyses were conducted by GE Nuclear Energy in the early 1990s. These analyses examined the effects of the degradation on the structural integrity. The current study adopts many of the same assumptions and data used in the previous GE study. However, the additional computational recourses available today enable the construction of a larger and more sophisticated structural model.

  6. Navajo Generating Station and Federal Resource Planning; Volume 1: Sectoral, Technical, and Economic Trends

    SciTech Connect

    Hurlbut, David; Haase, Scott; Barrows, Clayton; Bird, Lori; Brinkman, Greg; Cook, Jeff; Day, Megan; Diakov, Victor; Hale, Elaine; Keyser, David; Lopez, Anthony; Mai, Trieu; McLaren, Joyce; Reiter, Emerson; Stoll, Brady; Tian, Tian; Cutler, Harvey; Bain, Dominique; Acker, Tom

    2016-11-01

    This study for the U.S. Bureau of Reclamation examines conditions in the electricity sector that are likely to affect federal decisions with respect to Navajo Generating Station (NGS), the largest coal-fired power plant operating in the western United States. The federal government owns 24.3% of the 2.25-gigawatt plant, which amounts to 547 megawatts (MW) of capacity. By focusing on the unique public interests that depend on the federal share of NGS, this baseline study can help the federal government develop a road map for meeting all of its goals with respect to water delivery, clean energy, emission reduction, and economic development. There is no recommendation for action in this report. Rather, its aim is to provide a credible, thorough description of baseline conditions that might affect federal decisions regarding NGS. It describes facts and trends embedded in current data, but there are no conclusions about how Reclamation or DOI should respond to the trends. The interdependencies among the many sectoral trends and federal goals are complex, and the aim of this study is to provide a foundation from which options can be tested in a deliberate manner.

  7. Elimination of redundant thermoluminescent dosemeter monitoring at Oyster Creek nuclear generating station

    SciTech Connect

    Schwartz, P.E.

    1989-01-01

    The Oyster Creek direct radiation monitoring network has long been operating using several time-scale measurements. This network is used to assess the radiation levels during normal plant operations as well as to set the background radiation levels used to determine the radiological impact of a nonroutine release of radioactivity from the plant. Through analysis of the behavior of the monthly and quarterly activity of several types of direct radiation monitoring, the successful elimination of redundant and artificially high measurement techniques has been done in concert with providing the community with most efficient direct radiation monitoring methods. Dose rates from external radiation sources are measured around licensed U.S. Nuclear Regulatory Commission (NRC) facilities using passive detectors known as thermoluminescent dosimeters (TLDs). These detectors provide a quantitative measurement of the radiation levels in the are in which they are placed. The detected radiation could be the result of cosmic or naturally occurring origin in the air and on the ground, prior nuclear weapons testing, and activity from a nuclear facility. This paper describes the TLD network placed around the Oyster Creek nuclear generating station (OCNGS) and the comparisons between TLDs of different manufacturers and of different resident times and the successful elimination of the less accurate monthly TLD for the purpose of cost containment.

  8. Aging management program of the reactor building concrete at Point Lepreau Generating Station

    NASA Astrophysics Data System (ADS)

    Aldea, C.-M.; Shenton, B.; Demerchant, M. M.; Gendron, T.

    2011-04-01

    In order for New Brunswick Power Nuclear (NBPN) to control the risks of degradation of the concrete reactor building at the Point Lepreau Generating Station (PLGS) the development of an aging management plan (AMP) was initiated. The intention of this plan was to determine the requirements for specific structural components of concrete of the reactor building that require regular inspection and maintenance to ensure the safe and reliable operation of the plant. The document is currently in draft form and presents an integrated methodology for the application of an AMP for the concrete of the reactor building. The current AMP addresses the reactor building structure and various components, such as joint sealant and liners that are integral to the structure. It does not include internal components housed within the structure. This paper provides background information regarding the document developed and the strategy developed to manage potential degradation of the concrete of the reactor building, as well as specific programs and preventive and corrective maintenance activities initiated.

  9. Albright's hereditary osteodystrophy (pseudohypoparathyroidism type Ia): clinical case with a novel mutation of GNAS1.

    PubMed

    Garavelli, Livia; Pedori, S; Zanacca, C; Caselli, G; Loiodice, A; Mantovani, G; Ammenti, A; Virdis, Raffaele; Banchini, G

    2005-04-01

    Albright's hereditary osteodystrophy is characterized by ectopic calcification and ossification, round face, short hands and feet with short terminal phalanges, short metacarpals (especially 4th and 5th) and absence of the 4th knuckle (brachydactyly type E). Here we describe a case that recently came to our attention of a girl suffering from seizures caused by hypocalcaemia, in which the clinical diagnosis of Albright's hereditary osteodystrophy and Pseudohypoparathyroidism (PHP) (Pseudohypoparathyroidism Ia) was confirmed by DNA molecular analysis. This analysis revealed a novel mutation of GNAS 1, resulting in the nonsense mutation of exon 13 (CAG-->TAG, codon 384). This result expands the spectrum of GNAS1 mutations associated with this disorder.

  10. Remote-sensing satellite ground station evaluation using QPSK emulator with test pattern and PRBS generation

    NASA Astrophysics Data System (ADS)

    Srinivas, R.; Nithyanandan, L.; Umadevi, G.; Padmavathi, C. S.; Nayani, Radha

    2015-12-01

    In order to validate the performance of X-band (8000-8400 MHz) remote-sensing satellite receive chain, when the satellite is not in the vicinity of ground station, local loop end-end evaluation tests are mandatory to certify the RF downlink and base band receive chain performance. A customised test patterns compatible to IRS satellite series and PRBS sequence are generated, which are modulated using QPSK emulator to check and verify the satellite downlink chain performance. The design and implementation are done using novel digital techniques, and QPSK modulator is integrated with Test pattern and PRBS generator using state-of-art FPGAs. The QPSK emulator output is connected to high-speed fibre optic link which transfers the signal to near field bore-site antenna system. The test signal is thus up converted from 2557.5 MHz (S-band) frequency to required satellite carrier frequency of 8212.5 MHz; the emulated test signal is radiated from bore-site antenna, which simulates real-time satellite data transmission from space. Thus, the signal received by the parabolic dish antenna is down converted to 720 MHz, demodulated, bit synchronized, clock recovered, and frame synchronized. The evaluation of frame sync errors is done for good video data quality check. Also in the QPSK emulator, there is option of PRBS mode. Hence, using this option, the RF downlink and receive chain are evaluated for good Bit error rate (BER). The BER requirement is 1 error (tolerable) in 106 Million bits. The QPSK emulator has the provision to support different frequencies and data rates corresponding to all IRS satellite missions.

  11. 78 FR 47795 - In the Matter of Entergy Nuclear Generation Company Pilgrim Power Station Independent Spent Fuel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    .... Licensees whose ISFSI is collocated with a power reactor may choose to comply with the U.S. Nuclear... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION In the Matter of Entergy Nuclear Generation Company Pilgrim Power Station Independent Spent...

  12. 75 FR 67784 - STP Nuclear Operating Company South Texas Project Electric Generating Station, Units 3 and 4...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... Water Act Section 402(p) Texas Pollutant Discharge Elimination System (TPDES) general permit for... surface water quality. BMPs would be ] described in a Stormwater Pollution Prevention Plan (SWPPP) that... COMMISSION STP Nuclear Operating Company South Texas Project Electric Generating Station, Units 3 and...

  13. 78 FR 45987 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... COMMISSION Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to the Primary Sampling System AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and combined... COLs were issued to Southern Nuclear Operating Company, Inc., and Georgia Power Company, Oglethorpe...

  14. 78 FR 45989 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... COMMISSION Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to the Primary Sampling System AGENCY: Nuclear Regulatory Commission. ACTION: Exemption and combined... COLs were issued to Southern Nuclear Operating Company, Inc., and Georgia Power Company, Oglethorpe...

  15. 75 FR 14211 - Southern California Edison, San Onofre Nuclear Generating Station, Unit 2 and Unit 3; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Southern California Edison, San Onofre Nuclear Generating Station, Unit 2 and Unit 3; Exemption 1.0 Background Southern California Edison (SCE, the licensee) is the holder of the Facility...

  16. 75 FR 71152 - Southern California Edison; San Onofre Nuclear Generating Station, Unit 2 and Unit 3; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Southern California Edison; San Onofre Nuclear Generating Station, Unit 2 and Unit 3; Exemption 1.0 Background Southern California Edison (SCE, the licensee) is the holder of the Facility...

  17. 75 FR 43579 - Exelon Generation Company, LLC; Victoria County Station, Units 1 and 2; Notice of Withdrawal of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Exelon Generation Company, LLC; Victoria County Station, Units 1 and 2; Notice of Withdrawal of Application for a Combined License By letter dated September 2, 2008, Exelon Nuclear Texas Holdings,...

  18. 75 FR 9623 - Arizona Public Service Company, et al.; Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Arizona Public Service Company, et al.; Palo Verde Nuclear Generating Station, Units 1, 2, and 3... Facility Operating License Nos. NPF-41, NPF-51, and NPF- 74, which authorize operation of the Palo...

  19. 75 FR 15745 - Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3... Operating License Nos. NPF-41, NPF-51, and NPF-74, which authorize operation of the Palo Verde...

  20. Status of the Mohave Generation Station pipeline coal dewatering evaluation 1989-1993

    SciTech Connect

    1993-12-31

    In July, 1989 two (2) prototype screen bowl centrifuges were installed at the Mohave Generating Station, Laughlin, Nevada. In the ensuing three year period both centrifuges were evaluated under a variety of operating conditions to assess process capabilities and on-line mechanical reliability. The long-term test format permitted a verification of centrifuge theory through the monitoring of actual machine performance. It further permitted a detailed analysis of mechanical reliability issues conducted throughout approximately 10,000 hours of run time. one of the principal driving forces of the evaluation was the control and moderation of spiraling maintenance costs associated with the existing solid bowl machines. Stringent requirements for on-line availability suggested that premium materials of construction would be justified above and beyond those normally encountered in coal preparation plant designs. Scheduled outages permitted a detailed evaluation of design components and a direct measurement of abrasion/erosion areas of the machines. Analysis of the results obtained to date suggested various improvements to the machine design to improve both process performance and mechanical reliability. The machine rotating assemblies, for example, will incorporate a modified bowl contour to promote even higher recovery than obtained to date. Similarly, to address reliability concerns, premium hardfacing materials will be integrated into the machine design at key wearing points. The desired end result is to obtain machines that can withstand the extremely abrasive coal slurry which represents the feed to the centrifuges. This paper will update the technical presentation entitled {open_quotes}Recent Developments in Pipeline Coal Dewatering{close_quotes} presented at the 1991 Conference.

  1. Cushing Syndrome in the McCune-Albright Syndrome

    PubMed Central

    Brown, Rebecca J.; Kelly, Marilyn H.; Collins, Michael T.

    2010-01-01

    Context: Cushing syndrome (CS) is a rare but potentially fatal feature of McCune-Albright syndrome (MAS). Optimal management, prognostic features, and long-term follow-up of this disorder have not been described. Setting: The study was conducted at an academic tertiary care center. Patients: A total of 112 patients participating in a natural history study at the National Institutes of Health (NIH) were evaluated, and 21 published cases were reviewed. Interventions: Subjects received observation, medical management, or bilateral adrenalectomy. Main Outcome Measures: We measured prevalence, prognostic factors, and natural history. Results: The prevalence of CS among NIH patients was 7.1%. The median age at diagnosis was 3 months. Clinical features included “Cushingoid facies” (66.7%), failure to thrive (60.0%), low birth weight (50.0%), liver disease (36.7%), and heart disease (26.7%). Six patients (20.0%) died, four after adrenalectomy. Death was more likely in patients with comorbid heart disease (odds ratio, 13.3; P < 0.05). Of 23 survivors, 13 underwent adrenalectomy, and 10 exhibited spontaneous resolution. Two patients with spontaneous resolution who were tested later in life (3 and 15 yr after resolution) continued to have low-level, autonomous adrenal function with biochemical adrenal insufficiency. Compared to MAS patients without CS, patients with CS were more likely to have a cognitive/developmental disorder (44.4 vs. 4.8%; P < 0.001; odds ratio, 8.8). Conclusions: Comorbid heart and liver disease were poor prognostic markers and may indicate the need for prompt adrenalectomy. The high incidence of cognitive disorders indicates a need for close developmental follow-up and parental counseling. Patients with spontaneous resolution of CS may develop adrenal insufficiency, and they require long-term monitoring. PMID:20157193

  2. Analysis of the GNAS1 gene in Albright's hereditary osteodystrophy.

    PubMed

    Ahrens, W; Hiort, O; Staedt, P; Kirschner, T; Marschke, C; Kruse, K

    2001-10-01

    Albright's hereditary osteodystrophy (AHO) is characterized by phenotypic signs that typically include brachydactyly and sc calcifications occurring with or without hormone resistance toward PTH or other hormones such as thyroid hormone or gonadotropins. Different inactivating mutations of the gene GNAS1 encoding Gsalpha lead to a reduced Gsalpha protein activity in patients with AHO and pseudohypoparathyroidism type Ia or without resistance to PTH (pseudopseudohypoparathyroidism). We investigated 29 unrelated patients with AHO and pseudohypoparathyroidism type Ia or pseudopseudohypoparathyroidism and their affected family members performing functional and molecular genetic analysis of Gsalpha. In vitro determination of Gsalpha protein activity in erythrocyte membranes was followed by the investigation of the whole coding region of the GNAS1 gene using PCR, nonisotopic single strand conformation analysis, and direct sequencing of the PCR products. All patients showed a reduced Gsalpha protein activity (mean 59% compared with healthy controls). In 21/29 (72%) patients, 15 different mutations in GNAS1 including 11 novel mutations were detected. In addition we add five unrelated patients with a previously described 4 bp deletion in exon 7 (Delta GACT, codon 189/190), confirming the presence of a hot spot for loss of function mutations in GNAS1. In eight patients, no molecular abnormality was found in the GNAS1 gene despite a functional defect of Gsalpha. We conclude that biochemical and molecular analysis of Gsalpha and its gene GNAS1 can be valuable tools to confirm the diagnosis of AHO. However, in some patients with reduced activity of Gsalpha, the molecular defect cannot be detected in the exons encoding the common form of Gsalpha.

  3. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study.

    PubMed

    Wójcik, Sylwia; Koszowski, Rafał; Drozdowska, Bogna; Śmieszek-Wilczewska, Joanna; Raczkowska-Siostrzonek, Agnieszka

    2016-01-01

    McCune Albright syndrome (MCA) is a rare complication of genetic origin. The authors present a case study of a patient with MCA diagnosed with multifocal fibrous dysplasia in his limb and craniofacial bones. The symptoms of the disease in the patient's facial and oral tissue and the treatment administered have been described.

  4. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study

    PubMed Central

    Wójcik, Sylwia; Koszowski, Rafał; Drozdowska, Bogna; Śmieszek-Wilczewska, Joanna; Raczkowska-Siostrzonek, Agnieszka

    2016-01-01

    Abstract McCune Albright syndrome (MCA) is a rare complication of genetic origin. The authors present a case study of a patient with MCA diagnosed with multifocal fibrous dysplasia in his limb and craniofacial bones. The symptoms of the disease in the patient’s facial and oral tissue and the treatment administered have been described. PMID:28352837

  5. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Progress report Sep-Nov 81

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1982-06-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Competition among the species is being analyzed. In the fall of 1981, Teredo bartschi remained in Oyster Creek despite continuous prolonged outages of the Oyster Creek Nuclear Generating Station.

  6. The generation of simple compliance boundaries for mobile communication base station antennas using formulae for SAR estimation.

    PubMed

    Thors, B; Hansson, B; Törnevik, C

    2009-07-07

    In this paper, a procedure is proposed for generating simple and practical compliance boundaries for mobile communication base station antennas. The procedure is based on a set of formulae for estimating the specific absorption rate (SAR) in certain directions around a class of common base station antennas. The formulae, given for both whole-body and localized SAR, require as input the frequency, the transmitted power and knowledge of antenna-related parameters such as dimensions, directivity and half-power beamwidths. With knowledge of the SAR in three key directions it is demonstrated how simple and practical compliance boundaries can be generated outside of which the exposure levels do not exceed certain limit values. The conservativeness of the proposed procedure is discussed based on results from numerical radio frequency (RF) exposure simulations with human body phantoms from the recently developed Virtual Family.

  7. Low earth orbit environmental effects on the Space Station photovoltaic power generation systems

    NASA Technical Reports Server (NTRS)

    Nahra, H. K.

    1988-01-01

    A summary of the low earth orbital environment, its impact on the photovoltaic power systems of the Space Station and the solutions implemented to resolve the environmental concerns or issues are described. Low earth orbital environment (LEO) presents several concerns to the photovoltaic power systems of the Space Station. These concerns include atomic oxygen interaction with the polymeric substrate of the solar arrays, ionized environment effects on the array operating voltage, the effects of the meteoroids and debris impacts and penetration through the different layers of the solar cells and their circuits, and the high energy particle and radiation effects on the overall solar array performance. Potential solutions to some of the degrading environmental interactions that will provide the photovoltaic power system of the Space Station with the desired life are also summarized.

  8. Low Earth orbit environmental effects on the space station photovoltaic power generation systems

    NASA Technical Reports Server (NTRS)

    Nahra, Henry K.

    1987-01-01

    A summary of the Low Earth Orbital Environment, its impact on the Photovoltaic Power systems of the space station and the solutions implemented to resolve the environmental concerns or issues are described. Low Earth Orbital Environment (LEO) presents several concerns to the Photovoltaic power systems of the space station. These concerns include atomic oxygen interaction with the polymeric substrate of the solar arrays, ionized environment effects on the array operating voltage, the effects of the meteoroids and debris impacts and penetration through the different layers of the solar cells and their circuits, and the high energy particle and radiation effects on the overall solar array performance. Potential solutions to some of the degrading environmental interactions that will provide the photovoltaic power system of the space station with the desired life are also summarized.

  9. ECOSTRESS: NASA'S Next-Generation Mission to Measure Evapotranspiration from the International Space Station

    NASA Astrophysics Data System (ADS)

    Fisher, J. B.; Hook, S. J.; Allen, R. G.; Anderson, M. C.; French, A. N.; Hain, C.; Hulley, G. C.; Wood, E. F.

    2015-12-01

    In 2014, NASA selected the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) as part of the call for Earth Venture Instruments. Built and led out of the Jet Propulsion Laboratory (JPL), ECOSTRESS will produce Land Surface Temperature, Evapotranspiration, Water Use Efficiency, and Evaporative Stress Index data products at 38x57 m spatial resolution every few days from the International Space Station. Moreover, because of the shifting orbit of the Space Station, ECOSTRESS will be able to construct a diurnal cycle of measurements enabling detection of, for example, afternoon stomatal closure in water stressed areas; detection is further enhanced in heterogeneous environments (e.g., mixed-species forests, agricultural areas) by the high spatial resolution. ECOSTRESS is scheduled for launch in 2017.

  10. Verification and Validation of the GNSS Stations at the Prototype Core Site for NASA's Next Generation Space Geodesy Network

    NASA Astrophysics Data System (ADS)

    Desai, S. D.; Gross, J.; Haines, B. J.; Stowers, D. A.

    2013-12-01

    Two operational GNSS stations, GODN and GODS, were established within 100 m of each other at the prototype core site of NASA's next generation Space Geodesy Network. The planned network will co-locate each of the four space geodetic techniques, GNSS, SLR, VLBI, and DORIS, with the goal of meeting modern requirements for the International Terrestrial Reference Frame. This prototype site is located at NASA's Geophysical and Astronomical Observatory at the Goddard Space Flight Center. The two GNSS stations at the prototype site have been producing tracking data from the GPS, GLONASS, and Galileo constellations since January 17, 2012. We present results from the verification and validation of these two stations, focusing in particular on GPS-based positioning of these two sites to monitor their relative baseline vector. We compare baseline recovery from independent precise point positioning of each station to a network-based approach. We also show the impact on the baseline as well as station repeatability from various improvements to our processing approach, namely the application of empirical antenna calibrations, elevation-dependent weighting, and site-specific troposphere modeling. Together, these approaches have resulted in a factor of two improvement in the precision of the baseline length. The standard deviation of the baseline vector, when using independent precise positioning of each station, is 0.5, 0.4, 1.6, and 0.4 mm in the east, north, up, and length components. The difference between the GPS-based baseline length and that from an independent local tie survey is < 1 mm.

  11. Recommended practice for fire protection for electric generating plants and high voltage direct current converter stations. 2005 ed.

    SciTech Connect

    2005-07-01

    The standard outlines fire safety recommendations for gas, oil, coal, and alternative fuel electric generating plants including high voltage direct current converter stations and combustion turbine units greater than 7500 hp used for electric generation. Provisions apply to both new and existing plants. The document provides fire prevention and fire protection recommendations for the: safety of construction and operating personnel; physical integrity of plant components; and continuity of plant operations. The 2005 edition includes revisions and new art that clarify existing provisions. 5 annexes.

  12. A test program for predicting and monitoring the emergency diesel generator heat exchangers at Limerick Generating Station and Peach Bottom Atomic Power Station

    SciTech Connect

    Elder, J.J.; Fusegni, L.J.; McFarland, W.J.; Andreone, C.F.

    1995-12-31

    The USNRC issued Generic Letter 89-13, ``Service Water Problems Affecting Safety-Related Equipment`` to all nuclear power plant licensees which requires the implementation of a program to ensure that nuclear safety-related heat exchangers are capable of performing their intended functions. The heat exchangers on the standby emergency diesel generator (EDG) skids are covered by this requirement. PECo and SWEC have developed a program of testing and analysis to monitor the level of fouling in the EDG`s at the Limerick and Peach Bottom nuclear power plants in response to the Generic Letter. The development of an EDG heat exchanger test program is significantly more complex than for most other heat exchangers. This is because the process fluid flows are controlled by self-modulating thermostatic valves to maintain proper process temperature setpoints. As a result, under some test conditions the process flows may be reduced to as little as 20% of their design values. Flow changes of this magnitude significantly affect the performance of the coolers and obscure observation of the effects of fouling if not properly addressed. This paper describes the methods developed by PECo and SWEC to address this problem.

  13. Albright hereditary osteodystrophy with hypothyroidism, normocalcemia, and normal Gs protein activity: a family presenting with congenital osteoma cutis.

    PubMed

    Izraeli, S; Metzker, A; Horev, G; Karmi, D; Merlob, P; Farfel, Z

    1992-07-01

    The syndrome of Albright hereditary osteodystrophy (AHO), pseudohypoparathyroidism (PHP) and pseudopseudohypoparathyroidism (PPHP) is clinically and genetically heterogeneous. Classically, patients with PHP have the skeletal features of AHO, resistance to multiple hormones that work via cAMP such as parathyroid hormone and thyroid stimulating hormone, and deficient activity of Gs protein, the guanine nucleotide-binding protein that stimulates adenylate cyclase. However, patients without hormone resistance but with AHO and Gs deficiency were described (PPHP), as well as patients with multiple hormone resistance but without AHO or Gs deficiency. In a few patients with deficient Gs activity, hypothyroidism rather than hypocalcemia was the initial presentation of the disorder. We describe here a new variant of the syndrome, affecting 5 individuals in a 3 generation family with AHO, normal Gs activity and hypothyroidism. In the first 2 generations, mild features of AHO were present. The 2 sibs in the third generation had severe manifestations of AHO, including mild mental retardation as well as hypothyroidism. Diagnosis of congenital osteoma cutis at birth of the proband led to the diagnosis of the family. Elucidation of the molecular defect will shed light on the relationship between hormone resistance and AHO, as well as on the physiological mechanism of hormonal signal transduction.

  14. Bariatric surgery in an obese patient with Albright hereditary osteodystrophy: a case report.

    PubMed

    Ferrario, Chiara; Gastaldi, Giacomo; Portmann, Luc; Giusti, Vittorio

    2013-04-24

    We report for the first time the case of a patient with Albright hereditary osteodystrophy and pseudopseudohypoparathyroidism who underwent a Roux-en-Y gastric bypass. A 26-year-old obese Caucasian woman with Albright hereditary osteodystrophy with pseudopseudohypoparathyroidism (heterozygous mutation (L272F) in GNAS1 exon 10 on molecular analysis) was treated with gastric bypass. She had the classical features of Albright hereditary osteodystrophy: short stature (138cm), obesity (body mass index 49.5kg/m2), bilateral shortening of the fourth and fifth metacarpals, short neck, round and wide face with bombed front and small eyes. Before the gastric bypass was performed, biochemical determination revealed a slightly low serum calcium level (2.09mmol/L; normal range 2.1 to 2.5mmol/l), and an elevated parathyroid hormone level (87ng/L; normal range 10 to 70ng/L) associated with low vitamin D level (19μg/L; normal range 30 to 50μg/L). Vitamin D supplementation was prescribed before surgery. After the Roux-en-Y gastric bypass, she achieved a progressive substantial weight loss, from 94kg (body mass index 49.5kg/m2) to 49kg (body mass index 25.9kg/m2) in one year. Her weight then stabilized at 50kg (body mass index 26kg/m2) during our three years of follow-up. Before the operation and every three months after it, she was screened for nutritional deficiencies, and serum markers of bone turnover and renal function were monitored. Considering the deficiencies in zinc, magnesium, calcium, vitamin D and vitamin B12, appropriate supplementation was prescribed. Before and two years after the Roux-en-Y gastric bypass, a dual-energy X-ray absorptiometry assessment of bone density was performed that showed no changes on her lumbar column (0.882g/cm2 and both T-score and Z-score of -1.5 standard deviation). In addition, bone microarchitecture with a measurement of her trabecular bone score was found to be normal. This is the first case of Roux-en-Y gastric bypass described in a

  15. Life Science on the International Space Station Using the Next Generation of Cargo Vehicles

    NASA Technical Reports Server (NTRS)

    Robinson, J. A.; Phillion, J. P.; Hart, A. T.; Comella, J.; Edeen, M.; Ruttley, T. M.

    2011-01-01

    With the retirement of the Space Shuttle and the transition of the International Space Station (ISS) from assembly to full laboratory capabilities, the opportunity to perform life science research in space has increased dramatically, while the operational considerations associated with transportation of the experiments has changed dramatically. US researchers have allocations on the European Automated Transfer Vehicle (ATV) and Japanese H-II Transfer Vehicle (HTV). In addition, the International Space Station (ISS) Cargo Resupply Services (CRS) contract will provide consumables and payloads to and from the ISS via the unmanned SpaceX (offers launch and return capabilities) and Orbital (offers only launch capabilities) resupply vehicles. Early requirements drove the capabilities of the vehicle providers; however, many other engineering considerations affect the actual design and operations plans. To better enable the use of the International Space Station as a National Laboratory, ground and on-orbit facility development can augment the vehicle capabilities to better support needs for cell biology, animal research, and conditioned sample return. NASA Life scientists with experience launching research on the space shuttle can find the trades between the capabilities of the many different vehicles to be confusing. In this presentation we will summarize vehicle and associated ground processing capabilities as well as key concepts of operations for different types of life sciences research being launched in the cargo vehicles. We will provide the latest status of vehicle capabilities and support hardware and facilities development being made to enable the broadest implementation of life sciences research on the ISS.

  16. Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome.

    PubMed

    Carney, J Aidan; Young, William F; Stratakis, Constantine A

    2011-09-01

    McCune-Albright syndrome (polyostotic fibrous dysplasia, café-au-lait skin spots, and precocious puberty) is a genetically mosaic disorder with populations of mutant and normal cells in affected organs. Cushing syndrome, a rare feature of the condition, usually affects infants and is the result of corticotropin-independent primary bilateral adrenal disease, usually interpreted as nodular adrenocortical hyperplasia. In this study of 9 patients with Cushing syndrome and McCune-Albright syndrome, light microscopy revealed a characteristic bimorphic pattern of diffuse and nodular hyperplasia and a distinctive form of cortical atrophy with apparent zona glomerulosa hyperplasia in 8 patients, all very young. The pattern could be explained by the presence of a mosaic distribution of mutant and normal cells in the adrenal glands. The findings are different from those in inherited or other forms of genetically caused Cushing syndrome. The ninth patient, aged 17 years, had an adrenal adenoma and diffuse cortical hyperplasia in each adrenal gland.

  17. Goal-driven Automation of a Deep Space Communications Station: A Case Study in Knowledge Engineering for Plan Generation and Execution

    NASA Technical Reports Server (NTRS)

    Hill, R. W., Jr.; Chien, S. A.; Fayyad, K. V.; Chien, S.

    1997-01-01

    This paper describes the application of Artificial Intelligence techniques for plan generation, plan execution, and plan monitoring to automate a Deep Space Communication Station. This automation allows a Communication station to respond to a set of tracking goals by appropriately reconfiguring the communications hardware and software to provide the requested communications services.

  18. Awake Tracheal Intubation in an 8-Year-Old Girl with McCune-Albright Syndrome.

    PubMed

    Bohman, J Kyle; Segura, Leal

    2013-10-01

    An 8-year-old girl with McCune-Albright syndrome presented for resection of a very large fibrous dysplasia mass of the face with significant distortion of the airway anatomy. She had significant obstructive sleep apnea with daytime somnolence and hemoglobin oxygen desaturations while breathing room air preoperatively. We were able to successfully manage her airway by providing IV sedation, topical anesthesia of the airway, and oral fiberoptic intubation in close collaboration with our otorhinolaryngology colleagues.

  19. Aging of nuclear station diesel generators: Evaluation of operating and expert experience: Workshop

    SciTech Connect

    Hoopingarner, K.R.; Vause, J.W.

    1987-08-01

    Pacific Northwest Laboratory (PNL) evaluated operational and expert experience pertaining to the aging degradation of diesel generators in nuclear service. The research, sponsored by the US Nuclear Regulatory Commission (NRC), identified and characterized the contribution of aging to emergency diesel generator failures. This report, Volume II, reports the results of an industry-wide workshop held on May 28 and 29, 1986, to discuss the technical issues associated with aging of nuclear service emergency diesel generators. The technical issues discussed most extensively were: man/machine interfaces, component interfaces, thermal gradients of startup and cooldown and the need for an accurate industry database for trend analysis of the diesel generator system.

  20. Development of a computer program to generate typical measurement values for various systems on a space station

    NASA Technical Reports Server (NTRS)

    Deacetis, Louis A.

    1987-01-01

    The elements of a simulation program written in Ada were developed. The program will eventually serve as a data generator of typical readings from various space station equipment involved with Communications and Tracking, and will simulate various scenarios that may arise due to equipment malfunction or failure, power failure, etc. In addition, an evaluation of the Ada language was made from the viewpoint of a FORTRAN programmer learning Ada for the first time. Various strengths and difficulties associated with the learning and use of Ada are considered.

  1. Effect of Hurricane Andrew on the Turkey Point Nuclear Generating Station from August 20--30, 1992. [Final report

    SciTech Connect

    Hebdon, F.J.

    1993-03-01

    On August 24, 1992, Hurricane Andrew, a Category 4 hurricane, struck the Turkey Point Electrical Generating Station with sustained winds of 145 mph (233 km/h). This is the report of the team that the US Nuclear Regulatory Commission (NRC) and the Institute of Nuclear Power Operations (INPO) jointly sponsored (1) to review the damage that the hurricane caused the nuclear units and the utility`s actions to prepare for the storm and recover from it, and (2) to compile lessons that might benefit other nuclear reactor facilities.

  2. Building the Next Generation of Scientific Explorers through Active Engagement with STEM Experts and International Space Station Resources

    NASA Technical Reports Server (NTRS)

    Graff, P. V.; Vanderbloemen, L.; Higgins, M.; Stefanov, W. L.; Rampe, E.

    2015-01-01

    Connecting students and teachers in classrooms with science, technology, engineering, and mathematics (STEM) experts provides an invaluable opportunity for all. These experts can share the benefits and utilization of resources from the International Space Station (ISS) while sharing and "translating" exciting science being conducted by professional scientists. Active engagement with these STEM experts involves students in the journey of science and exploration in an enthralling and understandable manner. This active engagement, connecting classrooms with scientific experts, helps inspire and build the next generation of scientific explorers in academia, private industry, and government.

  3. A preliminary study on the effects of combined halogenation and thermal recirculation at a coal-fired generating station

    SciTech Connect

    Schnelle, R.C.; Strimple, P.D.

    1995-06-01

    East Bend Station is a single-unit, 650 megawatt, coal-fired generating station, located at Ohio River mile 510, near Rabbit Hash, Kentucky. Zebra mussel (Dreissena polymorpha) veligers were first detected at East Bend on 23 July 1992. Since then, the station has adopted a plan for preventing the settlement of zebra mussel veligers, by utilizing a combined halogenation and thermal recirculation treatment regime. A backflush pipeline was constructed, allowing 100% of the heated service water to be recycled through the intake well. During weekly treatments, the service water return to the river is valved out and water temperature is ramped up to between 31{degrees} - 35{degrees}C. HTH (calcium hypochlorite @65% available chlorine) is then slug-fed directly into the intake well. The temperature is maintained until the chlorine residual is below detectable limits. In addition to the weekly combined treatments, the service water system is also brominated for two hours, three times weekly, to 0.5 mg/1 TRO. Treatment efficacy is monitored, using a plexiglas biobox, seeded with adult mussels obtained from a substrate monitor attached to a barge cell and submerged to a depth of 3 meters. Preliminary results show both treatments to be ineffective for adult kill, however, it is believed that any newly-settle juveniles are being killed. Intake and equipment inspections during an upcoming unit outage will provide further verification. Additional testing, using various halogenation techniques, will be conducted during 1995.

  4. Inspiring the Next Generation: Student Experiments and Educational Activities on the International Space Station, 2000-2006

    NASA Technical Reports Server (NTRS)

    Thomas, Donald A.; Robinson, Julie A.; Tate, Judy; Thumm, Tracy

    2006-01-01

    One important objective of NASA has always been to inspire the next generation. NASA and human space flight have a unique ability to capture the imaginations of both students and teachers. The presence of humans onboard the International Space Station (ISS) for more than five years now has provided a foundation for numerous educational activities aimed at capturing the interest and motivating study in the sciences, technology, engineering, and mathematics. Yet even before the Expedition 1 crew arrived at station in November 2000, experiments with student participation were being conducted onboard ISS in support of NASA missions. One of NASA's protein crystal growth experiments had been delivered to station by the shuttle Atlantis during STS-106 in September 2000 and was returned to Earth six weeks later aboard the shuttle Discovery during the STS-92 mission. From very early on it was recognized that students would have a strong interest in the ISS, and that this would provide a unique opportunity for them to get involved and participate in science and engineering projects on ISS. It should be noted that participation is not limited to U.S. students but involves the 16 International Partner countries and various other countries under special commercial agree

  5. Meteorological Processes Affecting the Transport of Emissions from the Navajo Generating Station to Grand Canyon National Park.

    NASA Astrophysics Data System (ADS)

    Lindsey, Charles G.; Chen, Jun; Dye, Timothy S.; Willard Richards, L.; Blumenthal, Donald L.

    1999-08-01

    During the 1990 Navajo Generating Station (NGS) Winter Visibility Study, a network of surface and upper-air meteorological measurement systems was operated in and around Grand Canyon National Park to investigate atmospheric processes in complex terrain that affected the transport of emissions from the nearby NGS. This network included 15 surface monitoring stations, eight balloon sounding stations (equipped with a mix of rawinsonde, tethersonde, and Airsonde sounding systems), three Doppler radar wind profilers, and four Doppler sodars. Measurements were made from 10 January through 31 March 1990. Data from this network were used to prepare objectively analyzed wind fields, trajectories, and streak lines to represent transport of emissions from the NGS, and to prepare isentropic analyses of the data. The results of these meteorological analyses were merged in the form of a computer animation that depicted the streak line analyses along with measurements of perfluorocarbon tracer, SO2, and sulfate aerosol concentrations, as well as visibility measurements collected by an extensive surface monitoring network. These analyses revealed that synoptic-scale circulations associated with the passage of low pressure systems followed by the formation of high pressure ridges accompanied the majority of cases when NGS emittants appeared to be transported to the Grand Canyon. The authors' results also revealed terrain influences on transport within the topography of the study area, especially mesoscale flows inside the Lake Powell basin and along the plain above the Marble Canyon.

  6. Severe arterial hypertension: a possible complication of McCune-Albright syndrome.

    PubMed

    Ohata, Yasuhisa; Yamamoto, Takehisa; Mori, Ikuko; Kikuchi, Toru; Michigami, Toshimi; Imanishi, Yasuo; Satomura, Kenichi; Ida, Shinobu; Ozono, Keiichi

    2009-07-01

    McCune-Albright syndrome is characterized by café-au-lait spot, multiple endocrine hyperfunction, and polyostotic fibrous dysplasia. A somatic point mutation of Gsalpha protein leads to an increase in the Gsalpha-associated hormone activity in McCune-Albright syndrome. Because cyclic adenosine 3',5'-monophosphate stimulates the dopamine beta hydroxylase gene, an activating mutation of the Gsalpha protein may cause the hyperproduction of norepinephrine via dopamine. We report on a 9-year-old girl with McCune-Albright syndrome complicated by severe arterial hypertension. The urinary excretion of norepinephrine was 5- to 10-fold higher than in age-matched controls. Meta-iodobenzylguanidine scintigraphy and positron emission tomography/computed tomography (PET/CT) revealed no hot spots. These findings suggest that severe hypertension might be due to an activating mutation of Gsalpha protein in sympathetic ganglia. Because of the reported association of GNAS1 gene polymorphism with hypertension, our patient provides further evidence for a role of Gsalpha protein in hypertension.

  7. Albright hereditary osteodystrophy and del(2)(q37.3) in four unrelated individuals

    SciTech Connect

    Phelan, M.C.; Rogers, R.C.; Clarkson, K.B.

    1995-07-31

    Albright hereditary osteodystrophy (AHO) is a condition with characteristic physical findings (short stature, obesity, round face, brachydactyly) but variable biochemical changes (pseudohypoparathyroidism, pseudopseudohypoparathyroidism). Most patients with AHO have decreased activity of the guanine nucleotide-binding protein (G{sub s} protein) that stimulates adenylyl cyclase. The gene encoding the a subunit of the G{sub s} protein (GNAS1) has been mapped to the long arm of chromosome 20. We describe 4 unrelated individuals with apparent AHO, associated with small terminal deletions of chromosome 2. All 4 patients had normal serum calcium levels consistent with pseudopseudohypoparathyroidism. Del(2)(q37) is the first consistent karyotypic abnormality that has been documented in AHO. The finding of the same small terminal deletion in 4 unrelated individuals with a similar phenotype suggests that a gene locus in the 2q37 region is important in the pathogenesis of Albright syndrome. The association of Albright syndrome and the GNAS1 locus on chromosome 20 is well documented. The observation of a second potential disease locus on chromosome 2 may help explain the heterogeneity observed in this disorder. 44 refs., 7 figs.

  8. Albright's syndrome with acromegaly and Hashimoto's thyroiditis: report of a case.

    PubMed

    Huang, T S; Chang, C C; Huang, J S; Hsieh, H C; Chen, F W

    1990-08-01

    The case of a 35-year-old woman with Albright's syndrome, acromegaly and Hashimoto's thyroiditis is presented. She had noted deformity of the left mandible and chest from childhood. She developed persistent galactorrhea and amenorrhea after the delivery of her second child. X ray of the skull, and a head CT, revealed a pituitary tumor and fibrous dysplasia of the left mandible, sphenoid, zygomatic bone and pteryoid plate. Serum GH and PRL levels were markedly elevated. She received recontouring surgery of the left mandible, and a pathological examination confirmed the diagnosis of fibrous dysplasia. Chest X ray also showed fibrous dysplastic change of the left 4th, 5th, 6th and 7th ribs and left clavicle. Because of poor response to bromocriptine, she received a craniotomy to remove the pituitary macroadenoma. Pathological examination of the tumor revealed an acidophilic tumor. Postoperative radiotherapy was given for residual active tumor. She developed adrenal crisis two months after radiotherapy when she discontinued replacement therapy. The diagnosis of Hashimoto's thyroiditis was arrived at by palpation of the goiter, elevated thyroid antibodies, ultrasound pictures of the thyroid, fine needle aspiration cytology and hypothyroidism. To our knowledge, this is the first report of Albright's syndrome with Hashimoto's thyroiditis. The hypothesis of autoimmune disease is proposed to explain the hypofunction of the endocrine glands associated with Albright's syndrome.

  9. Water-related constraints to the development of geothermal electric generating stations

    SciTech Connect

    Robertson, R.C.; Shepherd, A.D.; Rosemarin, C.S.; Mayfield, M.W.

    1981-06-01

    The water-related constraints, which may be among the most complex and variable of the issues facing commercialization of geothermal energy, are discussed under three headings: (1) water requirements of geothermal power stations, (2) resource characteristics of the most promising hydrothermal areas and regional and local water supply situations, and (3) legal issues confronting potential users of water at geothermal power plants in the states in which the resource areas are located. A total of 25 geothermal resource areas in California, New Mexico, Oregon, Idaho, Utah, Hawaii, and Alaska were studied. Each had a hydrothermal resource temperature in excess of 150/sup 0/C (300/sup 0/F) and an estimated 30-year potential of greater than 100-MW(e) capacity.

  10. Formal on-the-job training programs at power generating stations

    SciTech Connect

    Hoch, R.R.

    1996-11-01

    On-the-Job Training (OJT) should be utilized for all posts in the stations. OJT for entry level positions should include training in many mundane areas that are often overlooked such as record keeping (log sheets and log books), proper communications and how to conduct himself or herself on the watch, during either emergency or routine situations. A separate OJT Program should be provided to prepare personnel to qualify for promotion to the next level. (Depending on any common agreements or bargaining unit contracts, OJT Programs can also be used to pre-qualify candidates for promotion to the next level.) By allowing the trainee to retain all OJT Program materials, it will also be available to him or her for continued reference or remedial training. (When an OJT Program is first instituted, it may be validated by issuing it to incumbent personnel and, subsequent, incorporating their comments or corrections.) This paper describes a formal OJT program.

  11. Aging of nuclear station diesel generators: Evaluation of operating and expert experience: Phase 1, Study

    SciTech Connect

    Hoopingarner, K.R.; Vause, J.W.; Dingee, D.A.; Nesbitt, J.F.

    1987-08-01

    Pacific Northwest Laboratory evaluated operational and expert experience pertaining to the aging degradation of diesel generators in nuclear service. The research, sponsored by the US Nuclear Regulatory Commission (NRC), identified and characterized the contribution of aging to emergency diesel generator failures. This report, Volume I, reviews diesel-generator experience to identify the systems and components most subject to aging degradation and isolates the major causes of failure that may affect future operational readiness. Evaluations show that as plants age, the percent of aging-related failures increases and failure modes change. A compilation is presented of recommended corrective actions for the failures identified. This study also includes a review of current, relevant industry programs, research, and standards. Volume II reports the results of an industry-wide workshop held on May 28 and 29, 1986 to discuss the technical issues associated with aging of nuclear service emergency diesel generators.

  12. Solar voltaic generator requirements for large-scale central-station

    SciTech Connect

    Canada, A.H.

    1982-09-01

    Solar Voltaic Generation (SVG) is ready to take its place alongside Coal Fired Generation (CFG) and Boiling Water Reactor Generation (BWRG) as a world strategic energy option in this century. In the U.S. National Energy Policy Plan, selection of an alternative SVG option, providing 10 Quads of prime energy electric generation, would ensure the U.S. as an oil exporting country and consume less capital and materials than the NEPP's coal-nuclear direction. The power engineering of SVG is comprised of four Subsystems, three of which are shown to be outside the photovoltaics industry but well within current utility industry engineering and manufacturing, and current utilities procurement and installation . . . requiring no turn-key contractor. Engineering and manufacturing requirements on the SVG Unit Subsystem and on the fuel (isolation) based plant availability and generation, the only concerns of the photovoltaic industry, are examined in the context of meeting this Solar Voltaic Generation-2000 goal for Energy Decency: Abundant, Affordable, Amicable in the Environment.

  13. Lessons from McCune-Albright syndrome-associated intraductal papillary mucinous neoplasms: : GNAS-activating mutations in pancreatic carcinogenesis.

    PubMed

    Parvanescu, Alina; Cros, Jérôme; Ronot, Maxime; Hentic, Olivia; Grybek, Virginie; Couvelard, Anne; Levy, Philippe; Chanson, Philippe; Ruszniewski, Philippe; Sauvanet, Alain; Gaujoux, Sebastien

    2014-08-01

    GNAS-activating mutations are reported in intraductal papillary mucinous neoplasms (IPMNs) and in McCune-Albright syndrome, characterized by fibrous dysplasia, precocious puberty, and café au lait spots. Recently, IPMNs have been described as a McCune-Albright syndrome-associated tumor, present in about 15% of patients. The aim of the present work was to assess the prevalence of polyostotic fibrous dysplasia and McCune-Albright syndrome among patients operated on for presumptive sporadic IPMNs. All patients operated on for IPMNs between January 1, 2007, and December 31, 2012, with available imaging were retrospectively screened for polyostotic fibrous dysplasia based on their preoperative abdominal or thoracoabdominal spiral computed tomography images. Systematic screening of 272 patients operated on for IPMNs revealed 1 patient with axial and peripheral polyostotic fibrous dysplasia and café au lait spots on clinical examination suggestive of McCune-Albright syndrome. This patient had been operated on for an unusually large invasive colloid adenocarcinoma (pT3N0M0 R0) derived from an intestinal subtype GNAS-mutated IPMN. The patient underwent adjuvant chemotherapy with gemcitabine for 6 months and was alive without recurrence 6 years later. Besides providing additional evidence of a syndromic IPMN as a feature of McCune-Albright syndrome, this observation is further evidence of the functional oncogenic consequences of GNAS mutations in the pancreas.

  14. Multi Station Frequency Response and Polarization of ELF/VLF Signals Generated via Ionospheric Modification

    NASA Astrophysics Data System (ADS)

    Maxworth, Ashanthi; Golkowski, Mark; University of Colorado Denver Team

    2013-10-01

    ELF/VLF wave generation via HF modulated ionospheric heating has been practiced for many years as a unique way to generate waves in the ELF/VLF band (3 Hz - 30 kHz). This paper presents experimental results and associated theoretical modeling from work performed at the High Frequency Active Auroral Research Program (HAARP) facility in Alaska, USA. An experiment was designed to investigate the modulation frequency dependence of the generated ELF/VLF signal amplitudes and polarization at multiple sites at distances of 37 km, 50 km and 99 km from the facility. While no difference is observed for X mode versus O mode modulation of the heating wave, it is found that ELF/VLF amplitude and polarization as a function of modulated ELF/VLF frequency is different for each site. An ionospheric heating code is used to determine the primary current sources leading to the observations.

  15. Weld program for nuclear power station steam generator replacement and disposal projects

    SciTech Connect

    Silvia, A.J.; Clark, H.F.

    1995-12-31

    The Steam Generator Replacement Project at Northeast Utilities` Millstone Unit No. 2 incorporated several welding innovations into its installation and disposal programs. An extensive Weld Procedure and Nondestructive Test Procedure development program was undertaken to ensure the feasibility and practicality of the weld techniques proposed for the steam generator installation and disposal project. The narrow groove technique development program examined porosity, crack sensitivity, and arc blow concerns. Reliable radiographic film interpretation and the ability to perform in-process weld repairs were also investigated. Various welding processes, filler materials and weld joint designs were studied to establish an acceptable weld technique for one-sided girth weld. Alloy steel weld procedures without preheat or postweld heat treatment were developed to ensure sound weldments with appropriate fracture toughness requirements to meet radioactive disposal shipping requirements. The weld procedure development program in conjunction with an established welder qualification and training program ensured a successful field implementation for the steam generator installation and disposal project.

  16. Evaluation of Electrochemically Generated Potable Water Disinfectants for Use on the International Space Station

    NASA Technical Reports Server (NTRS)

    Vega, Leticia; Aber, Gregory; Adam, Niklas; Clements, Anna; Modica, Catherine; Younker, Diane

    2011-01-01

    Microbial contamination and subsequent growth in spacecraft water systems are constant concerns for missions involving human crews. The current potable water disinfectant is iodine; however, with the end of the Space Shuttle program, there is a need to develop redundant biocide systems which are less dependent on hardware that would need to be launched on a regular basis. Three systems for electrochemical production of potable water disinfectants are being assessed for use on the International Space Station (ISS). Since there is a wide variability in the literature with regards to efficacy in both concentration and exposure time of these disinfectants, there is a need to establish baseline efficacy values. This paper describes a series of tests performed in order to establish optimal concentrations and exposure times for four disinfectants against single and mixed species planktonic and biofilm bacteria and to determine whether these electrochemical disinfection devices are able to produce a sufficient amount of chemical in both concentration and volume to act as a biocide for potable water on ISS.

  17. Evaluation of Electrochemically Generated Potable Water Disinfectants for Use on the International Space Station

    NASA Technical Reports Server (NTRS)

    Rodriquez, Branelle; Anderson, Molly; Anderson, Molly; Adam, Niklas; Vega, Leticia; Modica, Catherine; Bodkin, Douglas

    2012-01-01

    Microbial contamination and subsequent growth in spacecraft water systems are constant concerns for missions involving human crews. The current potable water disinfectant for the International Space Station (ISS) is iodine; however, with the end of the Space Shuttle program, there is a need to develop redundant biocide systems that do not require regular up ]mass dependencies. Throughout the course of a year, four different electrochemical systems were investigated as a possible biocide for potable water on the ISS. Research has indicated that there is a wide variability with regards to efficacy in both concentration and exposure time of these disinfectants, therefore baseline efficacy values were established. This paper describes a series of tests performed in order to establish optimal concentrations and exposure times for four disinfectants against single and mixed species planktonic and biofilm bacteria. Results of the testing determined whether these electrochemical disinfection systems are able to produce a sufficient amount of chemical in both concentration and volume to act as a biocide for potable water on ISS.

  18. Space Station Power Generation in Support of the Beta Gimbal Anomaly Resolution

    NASA Technical Reports Server (NTRS)

    Delleur, Ann M.; Propp, Timothy W.

    2003-01-01

    The International Space Station (ISS) is the largest and most complex spacecraft ever assembled and operated in orbit. The first U.S. photovoltaic (PV) module, containing two solar arrays, was launched, installed, and activated in early December 2000. After the first week of continuously rotating the U.S. solar arrays, engineering personnel in the ISS Mission Evaluation Room (MER) observed higher than expected electrical currents on the drive motor in one of the Beta Gimbal Assemblies (BGA), the mechanism used to maneuver a U.S. solar array. The magnitude of the motor currents continued to increase over time on both BGA's, creating concerns about the ability of the gimbals to continue pointing the solar arrays towards the sun, a function critical for continued assembly of the ISS. A number of engineering disciplines convened in May 2001 to address this on-orbit hardware anomaly. This paper reviews the ISS electrical power system (EPS) analyses performed to develop viable operational workarounds that would minimize BGA use while maintaining sufficient solar array power to continue assembly of the ISS. Additionally, EPS analyses performed in support of on-orbit BGA troubleshooting exercises is reviewed. EPS capability analyses were performed using SPACE, a computer code developed by NASA Glenn Research Center (GRC) for the ISS program office.

  19. Evaluation of Electrochemically Generated Potable Water Disinfectants for Use on the International Space Station

    NASA Technical Reports Server (NTRS)

    Rodriquez, Branelle; Anderson, Molly; Adams, Niklas; Vega, Leticia; Botkin, Douglas

    2013-01-01

    Microbial contamination and subsequent growth in spacecraft water systems are constant concerns for missions involving human crews. The current potable water disinfectant for the International Space Station (ISS) is iodine; however, with the end of the Space Shuttle Program, there is a need to develop redundant biocide systems that do not require regular up-mass dependencies. Throughout the course of a year, four different electrochemical systems were investigated as a possible biocide for potable water on the ISS. Research has indicated that a wide variability exists with regards to efficacy in both concentration and exposure time of these disinfectants; therefore, baseline efficacy values were established. This paper describes a series of tests performed to establish optimal concentrations and exposure times for four disinfectants against single and mixed species planktonic and biofilm bacteria. Results of the testing determined whether these electrochemical disinfection systems are able to produce a sufficient amount of chemical in both concentration and volume to act as a biocide for potable water on the ISS.

  20. Space Station Power Generation Investigated in Support of the Beta Gimbal Anomaly Resolution

    NASA Technical Reports Server (NTRS)

    Delleur, Ann M.; Propp, Timothy

    2004-01-01

    The International Space Station (ISS) is the largest and most complex spacecraft ever assembled and operated in orbit. The first U.S. photovoltaic module, containing two solar arrays, was launched, installed, and activated in early December 2000. After the first week of continuously rotating the U.S. solar arrays, engineering personnel in the ISS Mission Evaluation Room observed higher than expected electrical currents on the drive motor in one of the Beta Gimbal Assemblies (BGA), the mechanism used to maneuver a U.S. solar array (see the on-orbit photograph). The magnitude of the motor currents continued to increase over time on both BGAs, creating concerns about the ability of the gimbals to continue pointing the solar arrays towards the Sun, a function critical for continued assembly of the ISS. The BGA provides two critical capabilities to the ISS: (1) transfer of electrical power across a rotating joint and (2) positioning of the solar arrays. A number of engineering disciplines convened in May 2001 to address this on-orbit hardware anomaly. Over the course of a year, many scenarios were developed and used. Only two are discussed here: parked arrays and dual-angle mode.

  1. Chemical mixing model of streamflow generation at La Selva Biological Station, Costa Rica

    NASA Astrophysics Data System (ADS)

    Genereux, David; Pringle, Catherine

    1997-12-01

    La Selva Biological Station occupies an area of lowland tropical rainforest in central Costa Rica. Sodium and chloride data were used to quantify the mixing proportions of local runoff and geothermal groundwater at several sites throughout the stream channel system in late April, at the end of the dry season. The fraction of streamflow accounted for by geothermal groundwater varied spatially between 0 and 0.85, indicating a significant contribution to streamflow and to stream solute loads from geothermal groundwater at some sites. In general, higher inputs of geothermal groundwater were found at lower elevations. Over half the flow from one basin (the Salto) was due to geothermal groundwater, suggesting a minimum annual runoff of about 0.7 m of geothermal groundwater from this basin. A plot of {Na}/{Cl} vs. fraction of geothermal groundwater revealed watershed-scale chemical differences between the two major drainage systems (the Sura and the Salto), differences that were not apparent from a traditional two-solute plot of Cl vs. Na concentration. A small (21 mm) storm produced relatively little change in mixing proportions, as most throughfall was apparently retained in the relatively dry soils.

  2. Space Station momentum control and reboost requirements for two power generation concepts

    NASA Technical Reports Server (NTRS)

    Farmer, J. T.; Lovelace, U. M.; Badi, D. M.; Cuddihy, W. F.

    1986-01-01

    Results are presented of dynamic structural analyses of 75 and 300 kW versions of a solar dynamic (SD) power supply for the Space Station (MSS). The SD is being seriously considered as an alternative to solar panels due to lower areal and mass requirements and higher efficiencies. The functioning principle is to use parabolic concentrators to focus sunlight on a heat engine to boil liquids to drive a turbine. Potential problems are foreseen in terms of the torques which would be experienced by the MSS and the subsequent orbital stability effects. The stability would be altered by changing aerodynmaic drag, altered moment of inertia and angular momentum and the altered center of mass location. The problem is exacerbated by the need to first equip the MSS with solar panels while the SD technology is developed. The analysis shows that the attitude control system will need to be redesigned and resized to accommodate MSS growth with either power system. The effects of the rotating parts of the SD system can be minimized, but further studies are required to determine the effects on the pointing accuracy of the SD, which must be 10 times as precise as that needed by a photovoltaic array.

  3. Equating minimalist snowmelt and runoff generation models via validation with a wireless weather station network

    NASA Astrophysics Data System (ADS)

    Tobin, C. C.; Schaefli, B.; Nicotina, L.; Simoni, S.; Barrenetxea, G.; Parlange, M. B.; Rinaldo, A.

    2011-12-01

    A wireless network of 12 weather stations in the Val Ferret watershed (approximately 21 km2) in the Swiss Alps was used to validate snowmelt models with distributed temperature and radiation data. Using this extensive dataset, an improved yet simplistic degree-day method was compared with a radiation-based method proposed by Hock et al., 1999. The original degree-day approach is a widely used snowmelt model, relating snowmelt directly to air temperature. Numerous hydrological models use this minimalist approach due to its equivalent simplicity. Modifications of this simple method have been proposed in the past which typically incorporate local radiation conditions. However, these modifications generally require more data and/or a finer hydrological grid resolution. Results herein as well as theoretical considerations illustrate that the Hock point or grid-scale method is not always a robust method when combined with spatially explicit rainfall-runoff transformation models. This generalized hydrological application suggests that a simple diurnal cycle of the degree-day melt parameter has the potential to outperform the Hock local radiation-based approach for sub-daily melt simulations. We therefore suggest that the improved degree-day method enables a flexible melt modeling approach, which can be easily adapted into spatially-explicit hydrological models of varying complexity. Furthermore, as this new degree-day method is based upon solely daily temperature extremes, this approach is capable of being adapted for climate change predictions.

  4. Investigation into the High Voltage Shutdown of the Oxygen Generator System in the International Space Station

    NASA Technical Reports Server (NTRS)

    Carpenter, Joyce E.; Gentry, Gregory J.; Diderich, Greg S.; Roy, Robert J.; Golden, John L.; VanKeuren, Steve; Steele, John W.; Rector, Tony J.; Varsik, Jerome D.; Montefusco, Daniel J.; Wilson, Mark E.; Worthy, Erica S.

    2012-01-01

    The Oxygen Generation System (OGS) Hydrogen Dome Assembly Orbital Replacement Unit (ORU) serial number 00001 suffered a cell stack high-voltage shutdown on July 5, 2010. The Hydrogen Dome Assembly ORU was removed and replaced with the on-board spare ORU serial number 00002 to maintain OGS operation. The Hydrogen Dome Assembly ORU was returned from ISS on STS-133/ULF-5 in March 2011 with test, teardown and evaluation (TT&E) and failure analysis to follow.

  5. The development of thyroid storm in a child with McCune-Albright syndrome after orthopedic surgery.

    PubMed

    Lawless, S T; Reeves, G; Bowen, J R

    1992-09-01

    To report a case of thyroid storm that developed in a child with McCune-Albright syndrome after orthopedic surgery. The development of thyroid storm has not previously been described after surgery in a child. Descriptive case report. Pediatric intensive care unit. Patient with McCune-Albright syndrome who developed thyroid storm. SELECTION PROCEDURES AND INTERVENTIONS: Clinical features and treatment of thyroid storm are described. A highly sensitive immunochemiluminometric thyroid-stimulating hormone assay to help diagnose hyperthyroid states is also described. Before all operative procedures, children at high risk for thyroid dysfunction, including patients with McCune-Albright syndrome, should be screened and observed closely for the development of thyroid storm.

  6. Electrical Power Generated from Tidal Currents and Delivered to USCG Station Eastport, ME

    DTIC Science & Technology

    2011-01-21

    and can be highly  variable. Multiple analytical approaches are available for predicting the energy production  by a  hydrokinetic   turbine  at any given...35 Theory of Operation The ORPC Pre-Commercial Beta Turbine Generator Unit (“Beta TGU”) uses a hydrokinetic cross flow turbine based on Darrieus... turbine technology as its prime mover. The TGU is the core of ORPC’s proprietary technology and it uses hydrokinetic advanced design cross-flow

  7. Environmental radiological studies downstream from the Rancho Seco Nuclear Power Generating Station, 1985

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Brunk, J.L.; Jokela, T.A.

    1986-02-06

    Information compiled in 1985 while assessing the environmental impact of radionuclides previously discharged with aqueous releases from the Rancho Seco Nuclear Power Generating Plant is presented. In October 1984, the quantities of gamma-emitting radionuclides in water discharged to Clay Creek from the plant were reduced below operationally defined detection limits for liquid effluents. However, radionuclides previously discharged persist in the downstream environment and are found in many aquatic dietary components. /sup 134/Cs and /sup 137/Cs are the primary gamma-emitting radionuclides detected in the edible flesh of different fish, crayfish, and frogs. Coefficients for exponential equations are generated, from a least square analysis, that relate the change in concentration of /sup 137/Cs in fish to distance downstream and time between March and October 1985. Concentrations of /sup 137/Cs in surface creek sediments also decreased in the downstream direction much in the same manner as concentrations decreased in fish. However, there was no significant difference in the radiocesium concentrations in surface sediements collected from comparable locations during both 1984 and 1985.

  8. Seismic structural fragility investigation for the San Onofre Nuclear Generating Station, Unit 1 (Project I); SONGS-1 AFWS Project

    SciTech Connect

    Wesley, D.A.; Hashimoto, P.S.

    1982-04-01

    An evaluation of the seismic capacities of several of the San Onofre Nuclear Generating Station, Unit 1 (SONGS-1) structures was conducted to determine input to the overall probabilistic methodology developed by Lawrence Livermore National Laboratory. Seismic structural fragilities to be used as input consist of median seismic capacities and their variabilities due to randomness and uncertainty. Potential failure modes were identified for each of the SONGS-1 structures included in this study by establishing the seismic load-paths and comparing expected load distributions to available capacities for the elements of each load-path. Particular attention was given to possible weak links and details. The more likely failure modes were screened for more detailed investigation.

  9. The potential of biomass and animal waste of Turkey and the possibilities of these as fuel in thermal generating stations

    SciTech Connect

    Acaroglu, M.; Aksoy, A.S.; Oeguet, H.

    1999-05-01

    In this study, the potential of important biomass energy sources and animal solid wastes of Turkey were determined and the potential of these as a source of fuel in thermal generating stations to produce electricity was studied. The effects of biomass and lignite coal usage on the environment were reported comparatively. Considering total cereal products and fatty seed plants, approximately 50--65 million tons per year of biomass and 11,051 million tons of solid matter animal waste are produced, and 60% of biomass is seen as possible to use for energy. The primary energy of applicable biomass was evaluated as 467--623 Peta Joule (PJ) and the energy of animal residues as 50,172 PJ. This amount of energy is equal to 22--27% of Turkey`s annual primary energy consumption, (6,308 million tons of oil equivalent).

  10. Paralleling of two dissimilar main step-up transformers at the South Texas Project Electric Generating Station

    SciTech Connect

    Clark, L.H. ); Sinha, V.P.; Vaccaro, M.P. )

    1990-01-01

    The Main Step-up Transformers (MSTs) for each of the two units at the South Texas Project Electric Generating Station (STPEGS) consist of two parallel three phase transformer banks. As originally installed the transformers were of identical shell for design from a single manufacturer. Recently a high voltage bushing faulted to ground on one of the transformer, resulting in extensive transformer damage both internally and externally. As a result, the damaged transformer could not be repaired in place and required replacement. Since the lead time for an identical new transformer was at least one year and repair could take 6 to 8 months, a search for a compatible transformer was initiated. As a result of this search, four transformers were identified for initial analysis. Each one of these transformers was analyzed to determine which would be the most suitable for the application, from both electrical and physical aspects.

  11. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Progress report, December 1981-February 1982

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1982-08-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Competition among the species is being analyzed. In the winter of 1981, the generating station experienced a prolonged outage. The reproductive cycle of the shipworms was not extended. Teredo bartschi was very abundant at one station in Oyster Creek and moderately abundant at a second, but did not exist elsewhere in Barnegat Bay. Some specimens of Teredo bartschi contained larvae in the gills in February. According to laboratory experiments, Teredo navalis is able to remain active at temperatures as low as 4/sup 0/C, whereas T. bartschi ceases activity (withdraws its siphons) at about 13/sup 0/C. 12 tables.

  12. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Progress report, March-May 1982

    SciTech Connect

    Hoagland, K.E.

    1982-11-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Competition among the species is being analyzed. The adult population of Teredo bartschi survived the winter and spring of 1981-1982 better than it did previous cold periods without a thermal effluent. Lack of an effluent was due to a prolonged outage of the generating station. There was no spring outbreak of shipworms. The introduced species appears established at one station near but outside of Oyster Creek. Three teredinid species coexist in Oyster Creek. Larvae of T. bartschi and T. navalis have similar responses to reduced salinity. Bankia gouldi is the fastest-growing of the teredinids found in New Jersey, and as the lowest annual mortality.

  13. Sudden onset vision loss in an 8-year-old female with McCune-Albright syndrome.

    PubMed

    Kim, David; Wysong, Ashley; Lai, Jennifer; Alcorn, Deborah M; Benjamin, Latanya T

    2014-01-01

    We describe a case of an 8-year-old girl with large irregular café au lait macules on the right cheek and right lower extremity presenting with sudden onset vision loss and found to have polyostotic fibrous dysplasia on imaging. The classic triad of McCune-Albright syndrome is discussed along with the importance of recognition in patients with partial presentation. This case also highlights a rare and potentially devastating neurologic complication of McCune-Albright syndrome, as well as the need for early diagnosis and continual surveillance in these patients.

  14. Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy.

    PubMed

    Ringel, M D; Schwindinger, W F; Levine, M A

    1996-07-01

    Inactivating and activating mutations in the gene encoding G alpha s (GNAS1) are known to be the basis for 2 well-described contrasting clinical disorders, Albright hereditary osteodystrophy (AHO) and McCune-Albright syndrome (MAS). AHO is an autosomal dominant disorder due to germline mutations in GNAS1 that decrease expression or function of G alpha s protein. Loss of G alpha s function leads to tissue resistance to multiple hormones whose receptors couple to G alpha s. By contrast, MAS results from postzygotic somatic mutations in GNAS1 that lead to enhanced function of G alpha s protein. Acquisition of the activating mutation early in life leads to a more generalized distribution of the mosaicism and is associated with the classic clinical triad of polyostotic fibrous dysplasia, endocrine hyperfunction, and café au lait skin lesions described in MAS. Acquisition of a similar activating mutation in GNAS1 later in life presumably accounts for the restricted distribution of the gsp oncogene, and is associated with the development of isolated lesions (for example, fibrous dysplasia, pituitary or thyroid tumors) without other manifestations of MAS. Tissues that are affected by loss of G alpha s function in AHO are also affected by gain of G alpha s function in MAS, thus identifying specific tissues in which the second messenger cAMP plays a dominant role in cell growth, proliferation, or function. Further investigations of the functions of G alpha s and other members of the GTPase binding protein family will provide more insight into the pathogenesis and clinical manifestations of human disease.

  15. Endoscopic Decompression for Optic Neuropathy in McCune-Albright Syndrome.

    PubMed

    Noh, Jung-Hoon; Kong, Doo-Sik; Seol, Ho Jun; Shin, Hyung Jin

    2014-09-01

    McCune-Albright syndrome (MAS) is characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies including human growth hormone excess. Acromegaly as a manifestation of endocrine hyperfunction with MAS is uncommon. Surgical excision may be challenging due to the associated severe fibrous dysplasia of the skull base. Through the endoscopic procedures, we treated a case of MAS presenting with compressive optic neuropathy due to fibrous dysplasia and acromegaly caused by growth hormone secreting pituitary adenoma. We reviewed the literature on GH excess in MAS to highlight its surgical and medical challenges.

  16. Endoscopic Decompression for Optic Neuropathy in McCune-Albright Syndrome

    PubMed Central

    Noh, Jung-Hoon; Kong, Doo-Sik; Seol, Ho Jun

    2014-01-01

    McCune-Albright syndrome (MAS) is characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies including human growth hormone excess. Acromegaly as a manifestation of endocrine hyperfunction with MAS is uncommon. Surgical excision may be challenging due to the associated severe fibrous dysplasia of the skull base. Through the endoscopic procedures, we treated a case of MAS presenting with compressive optic neuropathy due to fibrous dysplasia and acromegaly caused by growth hormone secreting pituitary adenoma. We reviewed the literature on GH excess in MAS to highlight its surgical and medical challenges. PMID:25368777

  17. FluxSuite: a New Scientific Tool for Advanced Network Management and Cross-Sharing of Next-Generation Flux Stations

    NASA Astrophysics Data System (ADS)

    Burba, G. G.; Johnson, D.; Velgersdyk, M.; Beaty, K.; Forgione, A.; Begashaw, I.; Allyn, D.

    2015-12-01

    Significant increases in data generation and computing power in recent years have greatly improved spatial and temporal flux data coverage on multiple scales, from a single station to continental flux networks. At the same time, operating budgets for flux teams and stations infrastructure are getting ever more difficult to acquire and sustain. With more stations and networks, larger data flows from each station, and smaller operating budgets, modern tools are needed to effectively and efficiently handle the entire process. This would help maximize time dedicated to answering research questions, and minimize time and expenses spent on data processing, quality control and station management. Cross-sharing the stations with external institutions may also help leverage available funding, increase scientific collaboration, and promote data analyses and publications. FluxSuite, a new advanced tool combining hardware, software and web-service, was developed to address these specific demands. It automates key stages of flux workflow, minimizes day-to-day site management, and modernizes the handling of data flows: Each next-generation station measures all parameters needed for flux computations Field microcomputer calculates final fully-corrected flux rates in real time, including computation-intensive Fourier transforms, spectra, co-spectra, multiple rotations, stationarity, footprint, etc. Final fluxes, radiation, weather and soil data are merged into a single quality-controlled file Multiple flux stations are linked into an automated time-synchronized network Flux network manager, or PI, can see all stations in real time, including fluxes, supporting data, automated reports, and email alerts PI can assign rights, allow or restrict access to stations and data: selected stations can be shared via rights-managed access internally or with external institutions Researchers without stations could form "virtual networks" for specific projects by collaborating with PIs from

  18. Woody biomass-based bioenergy development at the Atikokan Power Generating Station: Local perceptions and public opinions

    NASA Astrophysics Data System (ADS)

    Baten, Cassia Sanzida

    To tackle climate change, reduce air pollution and promote development of renewable energy, the Ontario government is investing in the conversion of the coal-based Atikokan Power Generating Station (APGS) in Atikokan, Ontario, to woody biomass feedstock. This research offers one of the first looks at the perspectives of different individuals and groups on converting woody biomass to energy. Using a combination of study instruments which include literature review, surveys, interviews with key informants, semi-structured interviews, and focus group discussions, this dissertation uses qualitative research to provide a picture of the public's opinions and attitudes towards the APGS biomass energy development. Given Ontario's huge and sustainably managed forest resource, woody biomass is expected to be a major component of renewable energy production in Ontario. The move towards renewable energy that replaces fossil fuels with woody biomass will have considerable socio-economic implications for local and First Nation communities living in and around the bioenergy power generating station. Findings indicate that there is wide support for biomass utilization at the APGS by local people, especially since the project would create sustainable employment. The connection of woody biomass-based energy generation and rural community development provides opportunities and challenges for Atikokan's economic development. Respondents identified economic, environmental and social barriers to biomass utilization, and emphasized trust and transparency as key elements in the successful implementation of the APGS project. As demand for woody biomass-based energy increases, special attention will be needed to ensure and maintain the social, economic and environmental sustainability of biomass use at the APGS. In this research, respondents' views about biomass utilization for energy mainly focused on forest-related issues rather than energy. In Atikokan much of the project's social

  19. Integrated mild gasification processing at the Homer City Electric Power Generating Station site. Final report, July 1989--June 1993

    SciTech Connect

    Battista, J.J.; Zawadzki, E.A.

    1993-07-01

    A new process for the production of commercial grade coke, char, and carbon products has been evaluated by Penelec/NYSEG. The process, developed by Coal Technology Corporation, CTC, utilizes a unique screw reactor to produce a devolatilized char from a wide variety of coals for the production of commercial grade coke for use in blast furnaces, foundries, and other processes requiring high quality coke. This process is called the CTC Mild Gasification Process (MGP). The process economics are significantly enhanced by integrating the new technology into an existing power generating complex. Cost savings are realized by the coke producer, the coke user, and the electric utility company. Site specific economic studies involving the Homer City Generating Station site in Western Pennsylvania, confirmed that an integrated MGP at the Homer City site, using coal fines produced at the Homer City Coal Preparation Plant, would reduce capital and operating costs significantly and would enable the HC Owners to eliminate thermal dryers, obtain low cost fuel in the form of combustible gases and liquids, and obtain lower cost replacement coal on the spot market. A previous report, identified as the Interim Report on the Project, details the technical and economic studies.

  20. [Mazabraud and McCune-Albright syndromes in association : A case of two very rare orthopaedic tumour entities].

    PubMed

    Schwarze, M; Weber, M-A; Mechtersheimer, G; Lehner, B; Renker, E K

    2017-02-21

    We report on a 47-year-old woman with unilateral fibrous dysplasia and three intramuscular masses. Medical imaging revealed possible intramuscular myxomas, so that the suspected diagnosis was Mazabraud syndrome. After biopsy, the suspected diagnosis was verified by histology and molecular pathology. Due to endocrine abnormalities in the patient's medical history, McCune-Albright syndrome has was also verified.

  1. Endoscopic transsphenoidal excision of a GH-PRL-secreting pituitary macroadenoma in a patient with McCune-Albright syndrome.

    PubMed

    Natarajan, Manikandan S; Prabhu, Krishna; Chacko, Geeta; Rajaratnam, Simon; Chacko, Ari G

    2012-02-01

    We describe an endoscopic transsphenoidal excision of a GH-PRL-secreting pituitary adenoma and remodeling of frontotemporal fibrous dysplasia in a patient with McCune-Albright syndrome. Sphenoid dysplasia rendered transsphenoidal surgery challenging, but a study of the radiological anatomy and good surgical planning made this feasible. Medical therapy and radiation was required for persistent acromegaly after surgery.

  2. [Genetic counseling in osteodystrophy Albright's syndrome. Part II. GNAS1 gene and encoded protein function, genetic forecast and treatment].

    PubMed

    Janusz, Leszek; Morawska, Justyna; Wasilewska, Ewa; Sierakowski, Stanisław; Midro, Alina T

    2010-01-01

    In this article we describe localization and structure of genes from GNAS1 cluster, which mutations are responsible for characteristic group of features described mainly as Albright's syndrome. We present the capabilities of expressions of different phenotypes depending on types of molecular changes and possibilities of genetic prognosis with problems need to be solved in interdisciplinary support.

  3. Stressing of turbine-generator-exciter shafts by variable-frequency currents superimposed on DC currents in asynchronous HVDC links and following disturbances at converter stations

    SciTech Connect

    Hammons, T.J.; Bremner, J.J. )

    1994-09-01

    Ripple currents on the DC side of both HVDC synchronous and asynchronous. Links together with cleared HVDC and AC system disturbances can excite in some circumstances onerous torsional vibrations in large steam generator shafts. The problem has assumed importance in recent months on account of the HVDC Link between Scotland and Northern Ireland going ahead, on account of the proposed Eire/Wales Link, and because AC/DC/AC couplers are to be installed extensively to interconnect the East and West European Grid Systems. This paper discusses and analyses excitation of shaft torsional vibrations in steam turbine-generator-exciter shafts in close proximity to HVDC converter stations by (1) variable-frequency ripple currents superimposed on the DC currents in asynchronous Links, and (2) disturbances at bi-polar converter stations. The time response and tables show that for the systems studied variable-frequency ripple currents superimposed on the DC current in asynchronous Links can excite shaft torsional vibrations, the very small noncharacteristic currents could result in onerous shaft torques which might damage the machine, and that DC line faults at converter stations in close proximity of steam turbine-generator units can excite onerous turbine-generator shaft torsional response. Detailed simulation of the HVDC converter and generator is necessary for precise assessments of shaft torsional response following HVDC converter station faults. 500MW, 660MW, 1000MW and 1300MW machines are considered in the analyses that are made.

  4. McCune Albright syndrome in association with excessive GH secretion: case report.

    PubMed

    Özsu, Elif; Mutlu, Gül Yeşiltepe; Çizmecioğlu, Filiz Mine; Hatun, Şükrü

    2015-06-01

    McCune-Albright Syndrome is a rare syndrome characterized with excessive function of peripheral endocrine organs and activating mutations of the stimulatory G protein alpha subunit are involved in the pathogenesis. The three main findings of the disease include hyperpigmented café au lait spots, fibrous dysplasia and increased endocrine functions and excessive secretion of growth hormone is observed in 21% of the patients. Clinical signs may be missed in these patients because of precocious puberty and craniofacial fibrous dysplasia. Since radiotherapy causes to sarcomatous changes and transsphenoidal surgery may cause to severe thickening in the cranial bones, they are not appropriate treatment options and medical treatment is recommended. Bromocriptine, cabergoline and octreotide or different combinations of these drugs are used in treatment and pegvisomant has also been used in recent years. Here, we present a male patient aged 12 years and 7 months to show gigantism as a rare clinical reflection of McCune-Albright Syndrome with an excessive height (197 cm), café au lait spots, growht hormone levels which could not be supressed with oral glucose tolerance test and increased prolactin levels.

  5. Treatment of Pathological Bone Fractures in a Patient with McCune-Albright Syndrome.

    PubMed

    Kollerova, Jana; Koller, Tomas; Zelinkova, Zuzana; Kostalova, Ludmila; Payer, Juraj

    2013-01-01

    McCune-Albright syndrome is a rare genetic disorder with typical skeletal and endocrine manifestations. The disease course is complicated by recurrent fractures resulting from polyostotic fibrous dysplasia and the treatment is thus primarily directed at the reduction of the risk of fractures. However, due to the complex mechanism of the skeletal damage the standard antiporotic therapeutics are ineffective. We report here a case of a 31-year-old female, diagnosed with the McCune-Albright syndrome in early childhood. She was suffering from extensive bone involvement, complicated by recurrent fractures despite the treatment with bisphosphonates. In addition, the disease course was complicated by the impairment of several endocrine functions-precocious puberty, hyperestrogenism, and hyperthyroidism for which a total thyroidectomy was performed. During the operation, two enlarged parathyroid glands were removed. This resulted in severe hypocalcaemia in the postoperative period with a need for supplementation with very high calcium and vitamin D doses. After this episode, the patient has remained free of fractures. We discuss here the corrected thyroid function, the supplementation with unconventionally high doses of vitamin D and calcium, and the termination of bisphosphonates treatment as presumable factors contributing to the reduced fracture risk in this patient.

  6. Allergic manifestations and cutaneous histamine responses in patients with McCune Albright syndrome

    PubMed Central

    2013-01-01

    Background McCune Albright syndrome (MAS) is a rare disorder characterized by precocious puberty, café-au-lait spots, and fibrous dysplasia. Its cause is an activating mutation in the GNAS gene, encoding a subunit of the stimulatory G protein, Gsalpha (Gsα). The action of any mediator that signals via Gsα and cyclic AMP can be up regulated in MAS. We had observed gastritis, gastroesophageal reflux, and anaphylaxis in McCune Albright patients. Objective As histamine is known to signal via histamine 1 (H1) and histamine 2 (H2) receptors, which couple with stimulatory G proteins, we attempted to mechanistically link histamine responsiveness to the activating GNAS mutation. We hypothesized that responsiveness to histamine skin testing would differ between MAS patients and healthy controls. Patients and methods After obtaining informed consent, we performed a systematic review of histamine responsiveness and allergic manifestations in 11 MAS patients and 11 sex-matched, Tanner-stage matched controls. We performed skin prick testing, quantifying the orthogonal diameters of wheals and erythema. We also quantitated G protein mRNA expression. Results The peak wheal and flare responses to histamine were significantly higher in MAS patients compared to controls. Conclusions This study suggests that MAS patients may be at risk for exaggerated histamine responsiveness compared to unaffected controls. PMID:23663565

  7. A case of neonatal McCune-Albright syndrome with Cushing syndrome and hyperthyroidism.

    PubMed

    Yoshimoto, M; Nakayama, M; Baba, T; Uehara, Y; Niikawa, N; Ito, M; Tsuji, Y

    1991-10-01

    We describe a female newborn infant with McCune-Albright syndrome. In addition to the cutaneous pigmentation, she had apparent manifestations of hyperthyroidism and Cushing syndrome since birth. X-ray examinations showed many scattered lucencies in multiple bones. Endocrinological findings were as follows: serum T 4 276 nmol/l; free T 4 125 pmol/l; TSH less than 1 mU/l; serum cortisol greater than 2210 nmol/l; plasma ACTH less than 10 pg/ml; urinary free cortisol 865 nmol/day; estradiol 0.36 nmol/l. Regardless of treatment with antithyroid drugs and an inhibitor of 3 beta-hydroxysteroid dehydrogenase, the patient died of cardiac failure at the age of 4 months. Autopsy findings included a follicle cyst in the right ovary and multinodular hyperplasia in the thyroid and both adrenals. To our knowledge such a severe neonatal form of McCune-Albright syndrome has not been described in the literature.

  8. Fuller Albright. His concept of postmenopausal osteoporosis and what came of it.

    PubMed

    Forbes, A P

    1991-08-01

    Fifty years ago Albright contributed the following to understanding osteoporosis: (1) He recognized it as a deficiency of formation, not of mineralization of bone matrix; (2) he observed that 40 of 42 patients with osteoporosis before age 65 were women past menopause or young women postoophorectomy; (3) he concluded that estrogen stimulates osteoblasts (a conclusion later challenged); (4) he demonstrated by metabolic balance studies that estrogen causes a positive calcium balance in postmenopausal osteoporosis; (5) he introduced periodic progesterone to prevent or treat endometrial hyperplasia from prolonged estrogen therapy; and (6) he showed that long-term therapy arrested vertebral damage and height loss in postmenopausal osteoporosis and prevented them if started early. Since Albright's time, more sensitive methods of assessing bone density have replaced conventional roentgenograms. Some large scale trials of estrogen have indicated increased bone density and fewer fractures. Unopposed estrogen increases risk of endometrial cancer and decreases mortality from other cancers, myocardial infarction, stroke, and osteoporosis. Trials of calcitonin, diphosphonates, fluoride, vitamin D, and high calcium intake have not proved more effective than estrogen.

  9. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Progress report, 1 March-31 May 1980

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1980-12-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. The native species Teredo navalis and Bankia gouldi coexist with the introduced T. bartschi in Oyster Creek, at the mouth of Forked River and on the coast of the bay between the two creeks. Heavy mortality occurred in all species during winter and spring when the generating station was not operating. Temperature and salinity tolerance tests begun during April and May, 1980, were not completed by the end of May because the adult shipworms proved to be very resistant to drastic changes in these physical parameters.

  10. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Interim report 1 Sep 79-28 Feb 80

    SciTech Connect

    Hoagland, K.E.; Crocket, L.; Turner, R.D.

    1980-11-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Relative destructiveness and competition among the species are being analyzed. Teredo bartschi caused almost complete destruction of panels in Oyster Creek during the summer of 1979. Reproduction and settlement of this species continued into October. The native species Teredo navalis and Bankia gouldi coexist with T. bartschi in Oyster Creek. The greatest shipworm damage is in Oyster Creek. Heavy mortality occurs in all species during winter, especially in winters such as 1979-80 when the generating station is not operating. Adults of all three species can survive for at least 30 days at salinities from 5 to 45 parts per thousand by weight. They can withstand abrupt salinity changes.

  11. Proposal for all-optical generation of multiple-frequency millimeter-wave signals for RoF system with multiple base stations using FWM in SOA.

    PubMed

    Zhang, Chongfu; Wang, Leyang; Qiu, Kun

    2011-07-18

    An approach for the multiple-frequency millimeter-wave (mm-wave) signals generation is proposed and demonstrated, specifically, which can be applied to a radio-over-fiber (RoF) system with multiple base stations (BSs). In this scheme, optical double sideband (ODSB) modulation is achieved using a Mach-Zehnder modulator (MZM) to generate the two-sideband signals. New frequencies of the optical signals are obtained by using four-wave mixing (FWM) in a semiconductor optical amplifier (SOA). At the BSs, two different frequencies are achieved using a comb optical filter (COF), and which then input a photodiode (PD) to generate the mm-wave signals with the frequencies of 20, 40 or 60 GHz for different BSs, by mixing of these frequencies components. Experimental results verify that the proposed multiple-frequency mm-wave signals generation scheme for a RoF system with multiple base stations can work properly.

  12. Modernization of the first-generation Intercosmos laser rangefinder at the Zvenigorod experimental satellite-tracking station of the Astronomical Council of the USSR Academy of Sciences

    NASA Astrophysics Data System (ADS)

    Matveev, D. T.; Chepurnov, B. D.

    Test results obtained during 1980-1981 at the Zvenigorod station are presented for the Intercosmos laser rangefinder which was modified in various ways: e.g., optical components of the laser were replaced, and the mechanical Q-switch of the laser resonator was replaced by a phototropic Q-switch. Improved reliability was noted, and the ranging accuracy was increased by 1.5-2 times. It is concluded that the Zvenigorod tests indicate that the first-generation Intercosmos laser rangefinder can be effectively modernized at other Intercosmos tracking stations.

  13. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Quarterly report, 1 September-30 November 1980

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1981-04-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Relative destructiveness and competition among the species are being analyzed. The native species Teredo navalis and Bankia gouldi coexist with the introduced T. bartschi in Oyster Creek and at the mouth of Forked River.

  14. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Progress report 1 Jun-31 Aug 80

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1981-02-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Relative destructiveness and competition among the species are being analyzed. The native species Teredo navalis and Bankia gouldi coexist with the introduced T. bartschi in Oyster Creek. Teredo bartschi can withstand higher temperatures than the native species, but all species suffer osmotic stress at 6 parts per thousand by weight.

  15. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Quarterly progress report 1 Dec 80-28 Feb 81

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1981-08-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Relative destructiveness and competition among the species are being analyzed. The native species Teredo navalis and Bankia gouldi coexist with the introduced T. bartschi in Oyster Creek and at the mouth of Forked River. An increase in mortality occurred in January. By February, Teredo bartschi was found only at Bayside.

  16. The effects of scrubber installation at the Navajo Generating Station on particulate sulfur and visibility levels in the Grand Canyon.

    PubMed

    Green, Mark; Farber, Rob; Lien, Nghi; Gebhart, Kristi; Molenar, John; Iyer, Hari; Eatough, Delbert

    2005-11-01

    Grand Canyon National Park (GCNP) is a mandatory Class I federal area that is afforded visibility protection under the Federal Clean Air Act. In this paper, we have examined the effects on visibility and particulate sulfur (Sp) at GCNP as a result of reducing sulfur dioxide (SO2) emissions by 90% from the Navajo Generating Station (NGS). Scrubbers were retrofitted to each of the three units at NGS during 1997, 1998, and 1999. The Inter-agency Monitoring of Protected Visual Environments aerosol network database affords us an opportunity to examine trends in Sp and extinction both prescrubber and postscrubber. The NGS impacts GCNP primarily during the winter (December to February). During winter, at times, there are fogs, stratus, and high-relative humidity in the Grand Canyon. When the NGS plume interacts with these fogs and stratus, rapid conversion of SO2 to Sp can occur. A variety of analytical techniques were used, including cumulative frequency plots of Sp and extinction, and chemical mass balance and tracer source apportionment analysis. We also deployed P value statistical analysis of "extreme" Sp values. Before scrubbers were installed, values of Sp approaching 2 microg/m3 were occasionally observed. Because scrubbers have been installed, high levels of Sp have been markedly reduced. Statistical P value analysis suggests that these reductions were significant. Furthermore, we have also observed that Sp has been reduced throughout the cumulative frequency curve during winter by approximately 33% since scrubbers were installed. By contrast, during summer when the NGS impact on the Canyon is minimal, there has been only a relatively small decrease in Sp.

  17. Estimating cancer risk in relation to tritium exposure from routine operation of a nuclear-generating station in Pickering, Ontario.

    PubMed

    Wanigaratne, S; Holowaty, E; Jiang, H; Norwood, T A; Pietrusiak, M A; Brown, P

    2013-09-01

    Evidence suggests that current levels of tritium emissions from CANDU reactors in Canada are not related to adverse health effects. However, these studies lack tritium-specific dose data and have small numbers of cases. The purpose of our study was to determine whether tritium emitted from a nuclear-generating station during routine operation is associated with risk of cancer in Pickering, Ontario. A retrospective cohort was formed through linkage of Pickering and north Oshawa residents (1985) to incident cancer cases (1985-2005). We examined all sites combined, leukemia, lung, thyroid and childhood cancers (6-19 years) for males and females as well as female breast cancer. Tritium estimates were based on an atmospheric dispersion model, incorporating characteristics of annual tritium emissions and meteorology. Tritium concentration estimates were assigned to each cohort member based on exact location of residence. Person-years analysis was used to determine whether observed cancer cases were higher than expected. Cox proportional hazards regression was used to determine whether tritium was associated with radiation-sensitive cancers in Pickering. Person-years analysis showed female childhood cancer cases to be significantly higher than expected (standardized incidence ratio [SIR] = 1.99, 95% confidence interval [CI]: 1.08-3.38). The issue of multiple comparisons is the most likely explanation for this finding. Cox models revealed that female lung cancer was significantly higher in Pickering versus north Oshawa (HR = 2.34, 95% CI: 1.23-4.46) and that tritium was not associated with increased risk. The improved methodology used in this study adds to our understanding of cancer risks associated with low-dose tritium exposure. Tritium estimates were not associated with increased risk of radiationsensitive cancers in Pickering.

  18. McCune-Albright syndrome: persistence of autonomous ovarian hyperfunction during adolescence and early adult age.

    PubMed

    Matarazzo, Patrizia; Lala, Roberto; Andreo, Maria; Einaudi, Silvia; Altare, Franco; Viora, Elsa; Buzi, Fabio; De Luca, Filippo; De Sanctis, Vincenzo; Rigon, Franco; Wasniewska, Malgorzata; de Sanctis, Luisa; de Sanctis, Carlo

    2006-05-01

    Gonadal hyperfunction is the most frequent endocrine dysfunction in females with McCune-Albright syndrome (MAS). Peripheral precocious puberty is usually the first MAS manifestation in children, characterized by episodes of hypersecretion of estrogens with a consequent reduction in gonadotropin secretion. Little is known about the course of this endocrine disease in adolescence and during young adult life. The aim of this study was to evaluate ovarian function in 10 females with MAS (age 11.4-20.1 years) to detect the persistence of autonomous ovarian hyperfunction throughout and following adolescence, after at least 1 year wash out of any treatment for precocious puberty. LH, FSH, estradiol, prolactin, androgen secretion, ovarian and breast sonography in luteal and follicular phases of some menstrual cycles were evaluated. We demonstrated the persistence of some ovarian autonomy, documented by hyperestrogenism and/or low or absent gonadotropin secretion and/or ovarian cysts.

  19. Dental Perspectives in Fibrous Dysplasia and McCune-Albright Syndrome

    PubMed Central

    Akintoye, Sunday O.; Boyce, Alison M.; Collins, Michael T.

    2013-01-01

    McCune-Albright syndrome (MAS) is a rare multisystem disorder characterized by the triad of polyostotic fibrous dysplasia (PFD), endocrine disorders and café-au-lait skin pigmentation. Ninety percent of MAS patients have FD lesions in the craniofacial area, resulting in significant orofacial deformity, dental disorders, bone pain and compromised oral health. Maxillo-mandibular FD is also associated with dental developmental disorders, malocclusion, and high caries index. There is limited data on the outcomes of dental treatments in maxillo-mandibular FD/MAS patients, because clinicians and researchers have limited access to patients, and there are concerns that dental surgery may activate quiescent jaw FD lesions to grow aggressively. This report highlights current perspectives on dental management issues associated with maxillo-mandibular FD within the context of MAS. PMID:23953425

  20. Low serum free thyroxine level in a girl with McCune-Albright syndrome.

    PubMed

    Roosimaa, Mart; Pajuväli, Anett; Peet, Aleksandr; Tillmann, Vallo

    2015-01-05

    A 17-year-old girl with McCune-Albright syndrome (MAS) was suspected of having central hypothyroidism based on an inappropriately normal thyroid-stimulating hormone (TSH) and low free thyroxine (fT4). She was clinically euthyroid and her pituitary appeared normal on MRI. Treatment of hypothyroidism with levothyroxine resulted in suppression of TSH with a low fT4 and high free triiodothyronine (fT3) concentration and hence iatrogenic hyperthyroidism was diagnosed. After discontinuation of levothyroxine, the TSH and fT3 normalised while fT4 remained low. Increased conversion of thyroxine (T4) to triiodothyronine (T3) can be part of MAS. Therefore, fT3 and fT4 should both be measured when evaluating thyroid function in patients with MAS.

  1. Dental perspectives in fibrous dysplasia and McCune-Albright syndrome.

    PubMed

    Akintoye, Sunday O; Boyce, Alison M; Collins, Michael T

    2013-09-01

    McCune-Albright syndrome (MAS) is a rare multisystem disorder characterized by the triad of polyostotic fibrous dysplasia (FD), endocrine disorders, and café-au-lait skin pigmentation. Ninety percent of MAS patients have FD lesions in the craniofacial area, resulting in significant orofacial deformity, dental disorders, bone pain, and compromised oral health. Maxillomandibular FD is also associated with dental developmental disorders, malocclusion, and high caries index. There are limited data on the outcomes of dental treatments in maxillomandibular FD/MAS patients, because clinicians and researchers have limited access to patients, and there are concerns that dental surgery may activate quiescent jaw FD lesions to grow aggressively. This report highlights current perspectives on dental management issues associated with maxillomandibular FD within the context of MAS.

  2. McCune-Albright syndrome mimicking malignancy: an endocrine disease from oncologist's perspective.

    PubMed

    Genç, D Bahar; Özkan, M Alp; Büyükgebiz, Atilla

    2012-09-01

    Fibrous dysplasia (FD) is categorized as either monostotic or polyostotic and may occur as a component of McCune-Albright syndrome (MAS). Imaging findings can mimic neoplastic diseases. We present a case of MAS initially suspected to have neoplastic disease. A 9-year-old girl was admitted to pediatric emergency with ataxia. Upon hospitalization, an extradural mass was seen on cranial magnetic resonance imaging (MRI) and the bone survey showed lytic lesions in the long bones. The patient was referred to the pediatric oncology department with a presumptive diagnosis of Langerhans cell histiocytosis or metastatic tumor. Further investigations demonstrated that the patient had MAS and coexisting postinfectious cerebellitis. The findings in this patient demonstrate that the radiographic findings and the clinical presentation of FD and MAS may be similar to those of malignant diseases.

  3. Fibrous Dysplasia/McCune-Albright Syndrome: Clinical and Translational Perspectives.

    PubMed

    Robinson, Cemre; Collins, Michael T; Boyce, Alison M

    2016-10-01

    Fibrous dysplasia (FD) is an uncommon and debilitating skeletal disorder resulting in fractures, deformity, functional impairment, and pain. It arises from post-zygotic somatic activating mutations in GNAS, in the cAMP-regulating transcript α-subunit, Gsα. Constitutive Gs signaling results in activation of adenylyl cyclase and dysregulated cAMP production. In the skeleton, this leads to the development of FD lesions with abnormal bone matrix, trabeculae, and collagen, produced by undifferentiated mesenchymal cells. FD may occur in isolation or in combination with extraskeletal manifestations, including hyperfunctioning endocrinopathies and café-au-lait macules, termed McCune-Albright syndrome (MAS). This review summarizes current clinical and translational perspectives in FD/MAS, with an emphasis on FD pathogenesis, natural history, pre-clinical and clinical investigation, and future directions.

  4. Neonatal McCune-Albright syndrome with survival beyond two years.

    PubMed

    Pierce, Melinda; Scottoline, Brian

    2016-11-01

    McCune-Albright syndrome (MAS) is a rare disease resulting from a somatic, mosaic mutation of GNAS1 encoding the Gs α subunit of the G-protein coupled membrane receptor responsible for multiple hormonal signaling cascades. We present a patient with neonatal MAS who initially presented with neonatal diabetes and concern for congenital cardiac disease, and subsequently was found to have significant ACTH-independent neonatal Cushing syndrome. Her course included multi-system organ involvement, although she initially did not have obvious findings consistent with the MAS classic triad of café-au-lait macules, fibrous dysplasia, or peripheral precocious puberty. After medical and surgical treatment, she remains the only reported survivor of neonatal MAS. This clinical report alerts clinicians to the possibility of this disease in neonates with non-classical endocrine and non-endocrine manifestations of MAS, and demonstrates that this very early presentation is potentially survivable. © 2016 Wiley Periodicals, Inc.

  5. Eight-year follow-up of a girl with McCune-Albright syndrome.

    PubMed

    Aycan, Zehra; Önder, Aşan; Çetinkaya, Semra

    2011-01-01

    McCune-Albright syndrome (MAS) is characterized by the triad of fibrous dysplasia (FD), cafe-au-lait spots and precocious puberty (PP). We report a 14-year-old girl with MAS who has been followed-up for 8 years. She was referred for multiple fractures and vaginal bleeding at age 5.9 years. She had peripheral PP, FD, and osteoporosis and was diagnosed as MAS. The patient was treated with aromatase inhibitors and bisphosphonates. She had no menses during aromatase inhibitor treatment. Her growth rate and bone maturation were in normal ranges while on treatment. She had one new fracture on the seventh year of follow- up in spite of bisphosphonate treatment.

  6. Transsphenoidal approach for pituitary adenomas in patients with McCune-Albright syndrome.

    PubMed

    Dou, Wanchen; Di, Xiao; Wang, Renzhi; Zhu, Huijuan; Yao, Yong; Deng, Kan; Feng, Ming; Li, Guilin; Wei, Junji

    2013-06-01

    The feasibility of transsphenoidal approach under a guidance of neuronavigation was explored to remove pituitary adenomas for patients with McCune-Albright syndrome (MAS). From August, 2008 to July, 2010, there were 5 patients diagnosed with MAS associated with a pituitary adenoma in our department of Peking Union Medical College Hospital. All the patients underwent transsphenoidal surgery for the removal of pituitary adenomas with the assistant of neuronavigation and all the procedures went uneventfully. Four of the five patients have got cured radiologically by imaging and 3 of them have got cured based on endocrinological criteria. Transsphenoidal approach under the neuronavigational guidance is a safe and effective management for the MAS patients with pituitary adenomas.

  7. A Case of McCune-Albright Syndrome with Associated Multiple Endocrinopathies

    PubMed Central

    Sung, Sang Hun; Shon, Ho Sang; Kim, Hong Tae; Choi, Woo Young; Seo, Chang Jin; Lee, Joo Hyoung

    2007-01-01

    McCune-Albright syndrome (MAS) is a rare disorder that develops from an activating mutation in the Gs gene. It is characterized by an association with Polyostotic fibrous dysplasia, and precocious puberty, Caf-au-lait pigmentation, and other endocrinopathies that result from the hyperactivity of a variety of endocrine glands. Recently we encountered a patient with MAS with fibrous dysplasia, skin pigmentation, acromegaly, hyperprolactinemia and a thyroid nodule. A 23-year-old male presented for an evaluation of a change in his facial structures. Fibrous dysplasia was diagnosed by a bone biopsy and radiographic studies. The GH level increased paradoxically after an oral glucose load. The plasma prolactin, IGF-1 and alkaline phosphatase were high. Thyroid ultrasonography revealed multiple nodules. The brain MRI demonstrated a mass in the left pituitary gland. Genetic analysis identified a change from Arg (CGT) at codon 201 to Cys (TGT). PMID:17427647

  8. Persistent hyperestrogenism after precocious puberty in young females with McCune-Albright syndrome.

    PubMed

    Lala, Roberto; Andreo, Maria; Pucci, Angela; Matarazzo, Patrizia

    2007-08-01

    In this review we report the literature about ovarian function of young women with McCune-Albright Syndrome and describe our personal experience in the follow-up of a small cohort.Collectively, the existing data demonstrate that ovarian hyperfunction with ovarian cysts and hyperestrogenism persists in those women who had precocious puberty. The recording of menstrual cycles and the analysis of gonadotropin and estrogen secretion indicate that, when hypothalamic-pituitary pubertal activation begins, alternating episodes of gonadotropin control and ovarian autonomy can be seen. The persistence of estrogen hypersecretion causes menstrual disturbances and hypofertility. The long term consequences of this condition are hypothesized to be an increased risk of ductal breast cancer, which seems to be higher when growth hormone hypersecretion is also present. Therefore, young MAS women should receive counseling regarding fertility and ongoing surveillance for the development of estrogen related diseases.

  9. Laparoscopic management of ovarian cysts in peripheral precocious puberty of McCune-Albright syndrome.

    PubMed

    Gesmundo, Roberto; Guanà, Riccardo; Valfrè, Laura; De Sanctis, Luisa; Matarazzo, Patrizia; Marzari, Daniela; Lala, Roberto

    2006-05-01

    Ovarian cysts are common in peripheral precocious puberty in McCune-Albright syndrome (MAS). The clinical course of these cysts is unpredictable due to episodes of hyperestrogenism typical of MAS ovarian hyperfunction. In persistent and recurrent large ovarian cysts with sustained estrogen hypersecretion and relevant clinical disturbances (increased linear growth and bone age maturation, vaginal bleeding and psychological disturbances) treatment is mandatory. Experimental courses of estrogen-blocking drugs may have insufficient or nil therapeutic effects. In these cases and when molecular analysis is required to obtain MAS diagnosis as in isolated peripheral precocious puberty, surgery is the option. Laparoscopy minimizes surgical aggression and facilitates obtaining tissue samples for molecular analysis, and sometimes relieves hyperestrogenism with the excision of hyperactive ovarian areas. It can be conducted with trans-umbilical laparoscopic ovarian cystectomy (TULOC) before 3 years of age and with traditional techniques afterwards.

  10. Sinus pauses and high-grade atrioventricular block in Albright's hereditary osteodystrophy with pseudopseudohypoparathyroidism

    PubMed Central

    Rahmat, N; Venables, P

    2013-01-01

    Albright's hereditary osteodystrophy (AHO) is a rare inherited syndrome involving the molecular defects in the gene encoding the α subunit of the stimulatory G protein (Gsα). AHO has several variants, mainly pseudohypoparathyroidism (PHP) and pseudopseudohypoparathyroidism (PPHP). We present a family that share the same inactivating GNAS1 mutation, the daughter being affected by PPHP and her late father with PHP. The daughter, in her late teens, presented with a long history of presyncopal and syncopal attacks. Her father died suddenly in his mid-40 s. As expected, her laboratory tests to date have shown normal biochemistry and hormonal levels. Subsequently, an implantable loop recorder was inserted. This demonstrated extreme sinus pauses of >11 s and also high-grade atrioventricular block. A dual-chamber pacemaker was therefore inserted. PMID:23814007

  11. A novel GNAS1 mutation in a German family with Albright's hereditary osteodystrophy.

    PubMed

    Klagge, A; Jessnitzer, B; Pfaeffle, R; Stumvoll, M; Fuhrer, D

    2010-10-01

    Albright's hereditary osteodystrophy (AHO) is an inherited disorder and results from heterozygous loss of function mutation within the human G (s)α gene (GNAS1). AHO appears in two phenotypes, that may occur within the same family. Pseudohypoparathyroidism type Ia (PHP Ia) comprises the clinical features of AHO associated with parathyroid hormone (PTH) resistance while pseudo-pseudohypoparathyroidism (PPHP) includes AHO features without PTH resistance. In the present study we report a mother and a daughter with PPHP and PHP Ia respectively. The 13 exons of GNAS1 were analysed by PCR and direct sequencing. We identified a heterozygous missense mutation in exon 1. This novel mutation results in a stop at codon 35 and a truncated non-functional GNAS1 protein. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

  12. Albright's hereditary osteodystrophy associated with cerebellar pilocytic astrocytoma: coincidence or genetic relationship?

    PubMed

    Sobottka, S B; Huebner, A; Haase, M; Ahrens, W; Rupprecht, E; Schackert, H K; Schackert, G

    2001-01-01

    Albright's hereditary osteodystrophy (AHO) is a rare inherited disease characterized by skeletal abnormalities, short stature, and, in some cases, resistance to parathyroid hormone, resulting in pseudohypoparathyroidism (PHP). Heterozygous inactivating mutations of the GNAS1 gene are responsible for reduced activity of the alpha subunit of the Gs protein (G(Salpha)), a protein that mediates hormone signal transduction across cell membranes. G(salpha) is also known to have oncogenic potentials, leading to the development of human pituitary tumors and Leydig cell tumors. Here, we report the 1st case, a 3.5-year-old girl, with classic AHO phenotype and PHP type 1A associated with a cerebellar pilocytic astrocytoma. Coincidence or genetic relationships of both diseases are discussed according to molecular findings and current literature. Copyright 2001 S. Karger AG, Basel

  13. Resistance to growth hormone releasing hormone and gonadotropins in Albright's hereditary osteodystrophy.

    PubMed

    Mantovani, Giovanna; Spada, Anna

    2006-05-01

    Heterozygous inactivating mutations in the Gs alpha gene cause Albright's hereditary osteo-dystrophy (AHO). Consistent with the observation that only maternally inherited mutations lead to resistance to hormone action (pseudohypoparathyroidism type Ia [PHP-Ia), recent studies have provided evidence for a predominant maternal origin of Gs alpha transcripts in endocrine organs, such as thyroid, gonad and pituitary. Accordingly, patients with PHP-Ia display variable degrees of resistance to parathyroid hormone (PTH), thyroid stimulating hormone (TSH), gonadotropins and growth hormone (GH) releasing hormone (GHRH). Although the incidence and the clinical and biochemical characteristics of PTH and TSH resistance have been widely investigated and described, the cause and significance of the reproductive dysfunction in AHO is still poorly understood. The clinical finding of alterations of GH secretion in these patients was described for the first time only 2 years ago. The present report briefly reviews the literature focusing on the actual knowledge about these last two subjects.

  14. McCune–Albright syndrome with craniofacial dysplasia: Clinical review and surgical management

    PubMed Central

    Belsuzarri, Telmo Augusto Barba; Araujo, João Flavio Mattos; Melro, Carlos Alberto Morassi; Neves, Maick Willen Fernandes; Navarro, Juliano Nery; Brito, Leandro Gomes; Pontelli, Luis Otavio Carneiro; de Abreu Mattos, Luis Gustavo; Gonçales, Tiago Fernandes; Zeviani, Wolnei Marques

    2016-01-01

    Background: Fibrous dysplasia (FD) is a benign fibro-osseous lesion related to an abnormal bone development and replacement by fibrous tissue. FD has three clinical patterns namely monostotic, polyostotic, and the McCune–Albright syndrome (MAS). MAS is a rare genetic disorder (about 3% of all FD's) that comprises a triad of polyostotic FD, café-au-lait skin macules, and precocious puberty. MAS can involve the orbit region and cause stenosis in the optic canal, leading the patient to a progressive visual loss. Methods: We reported a case of craniofacial FD in MAS in a 9-year-old male with progressive visual loss, submitted to optic nerve decompression by fronto-orbito-zygomatic approach, with total recovery. A research was made at Bireme, PubMed, Cochrane, LILACS, and MEDLINE with the keywords: FD/craniofacial/McCune–Albright/Optic compression for the clinical review. Results: A clinical review of the disease was made, the multiple, clinical, and surgical management options were presented, and the case report was reported. Conclusion: MAS is a rare disease with a progressive polyostotic FD. Whenever it affects the orbit region, the optic canal, and it is associated with a progressive visual loss, the urgent optic nerve decompression is mandatory, either manually or with a rapid drill. It is known that aggressive approach is associated with less recurrence; it is also associated with worsening of the visual loss in optic nerve decompression. In MAS cases, multiple and less aggressive surgeries seem to be more suitable. PMID:27057395

  15. Mutations of the G sup s. alpha. -subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis

    SciTech Connect

    Weinstein, L.S.; Friedman, E.; Collins, R.M.; Spiegel, A.M.; Gejman, P.V.; Kadowaki, Takashi; Gershon, E.S. )

    1990-11-01

    Affected members of most kindreds with Albright hereditary osteodystrophy have a partial deficiency of functional G{sub s}, the guanine nucleotide-binding protein that stimulates adenylyl cyclase. By use of the polymerase chain reaction to amplify genomic fragments with the attachment of a high-melting G+C-rich region (GC clamp) and analysis of these fragments by denaturing gradient gel electrophoresis, heterozygous mutations in the G{sub s} {alpha}-subunit at the donor splice junction of intron 10 and a coding frameshift created by a single base deletion within exon 10. The findings illustrate the heterogeneity of genetic defects in Albright hereditary osteodystrophy and the usefulness of the polymerase chain reaction-denaturing gradient gel electrophoresis method to search rapidly for mutations in a large candidate gene.

  16. Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis.

    PubMed Central

    Weinstein, L S; Gejman, P V; Friedman, E; Kadowaki, T; Collins, R M; Gershon, E S; Spiegel, A M

    1990-01-01

    Affected members of most kindreds with Albright hereditary osteodystrophy have a partial deficiency of functional Gs, the guanine nucleotide-binding protein that stimulates adenylyl cyclase. By use of the polymerase chain reaction to amplify genomic fragments with the attachment of a high-melting G + C-rich region (GC clamp) and analysis of these fragments by denaturing gradient gel electrophoresis, heterozygous mutations in the Gs alpha-subunit gene were found in two kindreds. These included a G----C substitution at the donor splice junction of intron 10 and a coding frameshift created by a single base deletion within exon 10. The findings illustrate the heterogeneity of genetic defects in Albright hereditary osteodystrophy and the usefulness of the polymerase chain reaction-denaturing gradient gel electrophoresis method to search rapidly for mutations in a large candidate gene. Images PMID:2122458

  17. Post-Flight Microbial Analysis of Samples from the International Space Station Water Recovery System and Oxygen Generation System

    NASA Technical Reports Server (NTRS)

    Birmele, Michele N.

    2011-01-01

    The Regenerative, Environmental Control and Life Support System (ECLSS) on the International Space Station (ISS) includes the the Water Recovery System (WRS) and the Oxygen Generation System (OGS). The WRS consists of a Urine Processor Assembly (UPA) and Water Processor Assembly (WPA). This report describes microbial characterization of wastewater and surface samples collected from the WRS and OGS subsystems, returned to KSC, JSC, and MSFC on consecutive shuttle flights (STS-129 and STS-130) in 2009-10. STS-129 returned two filters that contained fluid samples from the WPA Waste Tank Orbital Recovery Unit (ORU), one from the waste tank and the other from the ISS humidity condensate. Direct count by microscopic enumeration revealed 8.38 x 104 cells per mL in the humidity condensate sample, but none of those cells were recoverable on solid agar media. In contrast, 3.32 x lOs cells per mL were measured from a surface swab of the WRS waste tank, including viable bacteria and fungi recovered after S12 days of incubation on solid agar media. Based on rDNA sequencing and phenotypic characterization, a fungus recovered from the filter was determined to be Lecythophora mutabilis. The bacterial isolate was identified by rDNA sequence data to be Methylobacterium radiotolerans. Additional UPA subsystem samples were returned on STS-130 for analysis. Both liquid and solid samples were collected from the Russian urine container (EDV), Distillation Assembly (DA) and Recycle Filter Tank Assembly (RFTA) for post-flight analysis. The bacterium Pseudomonas aeruginosa and fungus Chaetomium brasiliense were isolated from the EDV samples. No viable bacteria or fungi were recovered from RFTA brine samples (N= 6), but multiple samples (N = 11) from the DA and RFTA were found to contain fungal and bacterial cells. Many recovered cells have been identified to genus by rDNA sequencing and carbon source utilization profiling (BiOLOG Gen III). The presence of viable bacteria and fungi from WRS

  18. Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome.

    PubMed

    Tessaris, Daniele; Matarazzo, Patrizia; Mussa, Alessandro; Tuli, Gerdi; Verna, Francesca; Fiore, Ludovica; Lala, Roberto

    2012-01-01

    McCune-Albright Syndrome (MAS) is a congenital endocrine disorder due to mosaic tissutal hyper-function. We describe a boy with a molecularly confirmed MAS, clinically evident with congenital café-au-lait spots, bone fibrous dysplasia, hyperthyroidism, and renal phosphate wasting syndrome. At 4.6 years of age he disclosed a rapid progression of peripheral puberty, so we decided to treat him with bicalutamide 25 mg/day and anastrozole 1 mg/day. Combined third generation aromatase inhibitors - competitive androgen receptor blockers were employed in familial male precocious puberty (FMPP). Combined treatment was performed for 49 months from the age of 4.6 to 6.7 years. The patient underwent clinical, laboratory, and instrumental evaluation twice a year from the first admission to the current age. This treatment caused a rapid normalization of growth velocity, subsequent reduction of penile androgenization, and stabilization of testicular volume. The therapy was well tolerated for all its duration and neither side effects, nor secondary hypothalamic activation were noted. This report provides further evidence of effectiveness and safety of combined third generation aromatase inhibitors - competitive androgen receptor blockers in male precocious peripheral puberty, firstly employed in male MAS, and contributes to expand the spectrum of disorders in which their employment may reveal promising.

  19. Polyostotic fibrous dysplasia with gigantism and huge pelvic tumor: a rare case of McCune-Albright syndrome.

    PubMed

    Sakayama, Kenshi; Sugawara, Yoshifumi; Kidani, Teruki; Fujibuchi, Taketsugu; Kito, Katsumi; Tanji, Nozomu; Nakamura, Atsushi

    2011-06-01

    We report a rare case of polyostotic fibrous dysplasia on endocrine hyperfunction with elevated human growth hormone and normal serum level of prolactin. There were some differential points of gender, gigantism, endocrine function, and GNAS gene from McCune-Albright syndrome. Malignant transformation was suspected in the pelvic tumor from imaging because rapid growth of the tumor by imaging was observed; however, no malignant change occurred in this case.

  20. [McCune-Albright syndrome revealed by Blaschko-linear café-au-lait spots on the back].

    PubMed

    Jung, A-J; Soskin, S; Paris, F; Lipsker, D

    2016-01-01

    McCune-Albright syndrome is a rare sporadic disease defined by the triad of café-au-lait spots, fibrous dysplasia of bone and endocrine disorder. Diagnosis is classically confirmed by the presence of bone lesions or precocious puberty. We report a case of McCune-Albright syndrome diagnosed solely on the basis of the cutaneous signs. A four-year-old girl was seen in our clinic due to the presence of congenital café-au-lait spots on her back. These macules were irregular, with jagged borders, and were disposed in a broad band on the left shoulder and in the lumbar region, in a Blaschko-linear pattern. McCune-Albright syndrome was immediately suspected, despite the absence of other signs of the disease. Genetic assessment carried out a year and a half later confirmed the diagnosis, with arginine substitution at position 201 of Gs alpha protein. The child was still asymptomatic. Regular radiographic and endocrine assessments remained normal for three years until the sudden appearance at the age of seven years of precocious puberty and radiographic evidence of fibrous dysplasia of the right hand. Café-au-lait spots are very common in the general population. An underlying genetic disorder should only be sought when such spots are multiple. However, in the case of McCune-Albright syndrome, it is the irregular borders and the Blaschko-linear arrangement of the spots in broad irregular bands that are pathognomonic, reflecting as they do the genetic mosaicism characteristic of this disease. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  1. Solid radioactive waste management facility design for managing CANDU{sup R} 600 MW nuclear generating station re-tube/refurbishment Waste Streams

    SciTech Connect

    Pontikakis, N.; Hopkins, J.; Scott, D.; Bajaj, V.; Nosella, L.

    2007-07-01

    The main design features of the re-tube canisters, waste handling equipment and waste containers designed by Atomic Energy of Canada Limited (AECL{sup R}) and implemented in support of the re-tube/refurbishment activities for Candu 600 MW nuclear generating stations are described in this paper. The re-tube/refurbishment waste characterization and the waste management principles, which form the basis of the design activities, are also briefly outlined. (authors)

  2. Second Generation International Space Station (ISS) Total Organic Carbon Analyzer (TOCA) Verification Testing and On-Orbit Performance Results

    NASA Technical Reports Server (NTRS)

    Bentley, Nicole L.; Thomas, Evan A.; VanWie, Michael; Morrison, Chad; Stinson, Richard G.

    2010-01-01

    The Total Organic Carbon Analyzer (TOGA) is designed to autonomously determine recovered water quality as a function of TOC. The current TOGA has been on the International Space Station since November 2008. Functional checkout and operations revealed complex operating considerations. Specifically, failure of the hydrogen catalyst resulted in the development of an innovative oxidation analysis method. This method reduces the activation time and limits the hydrogen produced during analysis, while retaining the ability to indicate TOC concentrations within 25% accuracy. Subsequent testing and comparison to archived samples returned from the Station and tested on the ground yield high confidence in this method, and in the quality of the recovered water.

  3. Space Station

    NASA Image and Video Library

    1989-08-01

    In response to President Reagan's directive to NASA to develop a permanent marned Space Station within a decade, part of the State of the Union message to Congress on January 25, 1984, NASA and the Administration adopted a phased approach to Station development. This approach provided an initial capability at reduced costs, to be followed by an enhanced Space Station capability in the future. This illustration depicts the baseline configuration, which features a 110-meter-long horizontal boom with four pressurized modules attached in the middle. Located at each end are four photovoltaic arrays generating a total of 75-kW of power. Two attachment points for external payloads are provided along this boom. The four pressurized modules include the following: A laboratory and habitation module provided by the United States; two additional laboratories, one each provided by the European Space Agency (ESA) and Japan; and an ESA-provided Man-Tended Free Flyer, a pressurized module capable of operations both attached to and separate from the Space Station core. Canada was expected to provide the first increment of a Mobile Serving System.

  4. A new method to assess mercury emissions: a study of three coal-fired electric-generating power station configurations.

    PubMed

    Boylan, Helen M; Cain, Randy D; Kingston, H M

    2003-11-01

    U.S. Environmental Protection Agency (EPA) Method 7473 for the analysis of mercury (Hg) by thermal decomposition, amalgamation, and atomic absorption spectroscopy has proved successful for use in Hg assessment at coal-fired power stations. In an analysis time of approximately 5 min per sample, this instrumental methodology can directly analyze total Hg--with no discrete sample preparation--in the solid matrices associated with a coal-fired power plant, including coal, fly ash, bottom ash, and flue gas desulfurization (FGD) material. This analysis technique was used to investigate Hg capture by coal combustion byproducts (CCBs) in three different coal-fired power plant configurations. Hg capture and associated emissions were estimated by partial mass balance. The station equipped with an FGD system demonstrated 68% capture on FGD material and an emissions estimate of 18% (11 kg/yr) of total Hg input. The power plant equipped with low oxides of nitrogen burners and an electrostatic precipitator (ESP) retained 43% on the fly ash and emitted 57% (51 kg/yr). The station equipped with conventional burners and an ESP retained less than 1% on the fly ash, emitting an estimated 99% (88 kg/yr) of Hg. Estimated Hg emissions demonstrate good agreement with EPA data for the power stations investigated.

  5. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Progress report, September-November 1981

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1982-06-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Competition among the species is being analyzed. In the fall of 1981, Teredo bartschi remained in Oyster Creek despite continuous prolonged outages of the Oyster Creek Nuclear Generating Station. It did not spread to Forked River or Waretown as it had done in other years when the effluent was present. The peak in larval production and settlement of T. bartschi occurred between September and October. Settlement of shipworms occurred on no monthly panels except those in Oyster Creek during the period of this report. Laboratory experiments revealed that T. bartschi becomes inactive at 5/sup 0/C (24/sup 0///sub 00/) and T. navalis shows signs of osmotic stress below 10/sup 0///sub 00/ at 18/sup 0/C. The shipworms in Barnegat Bay do not show a preference for settling at the mudline when the substrate is not limited.

  6. 76 FR 45301 - PSEG Nuclear LLC, Hope Creek Generating Station; Notice of Issuance of Renewed Facility Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... generation, natural gas combined-cycle generation, combined alternative, and the no-action alternative. The....'' HCGS is a boiling water reactor located in Lower Alloways Creek Township, Salem County, New Jersey....

  7. Craniospinal Polyostotic Fibrous Dysplasia, Aneurysmal Bone Cysts, and Chiari Type 1 Malformation Coexistence in a Patient with McCune-Albright Syndrome.

    PubMed

    Urgun, Kamran; Yılmaz, Baran; Toktaş, Zafer Orkun; Akakın, Akın; Konya, Deniz; Demir, Mustafa Kemal; Kılıç, Türker

    2016-01-01

    Aneurysmal bone cysts (ABCs) are defined as benign cystic lesions of bone composed of blood-filled spaces. ABCs may be a secondary pathology superimposed on fibrous dysplasia (FD). Concomitant FD and ABC in relation with McCune-Albright syndrome is an extremely rare condition. Here, we report concomitant, double ABCs in bilateral occipital regions and FD from the skull base to the C2 vertebra with Chiari type 1 malformation. A 14-year-old female with a diagnosis of McCune-Albright syndrome presented with swellings at the back of her head. The lesions were consistent with ABCs and were totally resected with reconstruction of the calvarial defects. The coexistence of FD, bilateral occipital ABCs, and Chiari malformation type 1 in a McCune-Albright patient is an extremely rare condition and, to our knowledge, has not been reported to date. Exact diagnosis and appropriate surgical treatment usually lead to a good outcome.

  8. Generating a representative signal of coal ash content to anticipate combustion control in a thermal power station.

    PubMed

    Prieto-Fernández, Ismael; Santurio-Díaz, José M; Folgueras-Díaz, Belén; López-Bobo, M Rosario; Fernández-Viar, Pedro

    2004-05-01

    This paper describes the possibilities of continuously measuring coal ash in the boiler feeding circuit of a thermal power station so that the measurement can be used as a signal for the boiler combustion control system. An installation was designed, at semi-industrial scale, that could faithfully reproduce the operation of a belt feeder. In order to measure the ash content, a natural radioactivity meter was installed and a large number of coal samples with different ranks and grain sizes were tested, eventually showing the possibility of achieving the objective.

  9. Characterization of alternative electric generation technologies for the SPS comparative assessment: volume 2, central-station technologies

    SciTech Connect

    Not Available

    1980-08-01

    The SPS Concept Development and Evaluation Program includes a comparative assessment. An early first step in the assessment process is the selection and characterization of alternative technologies. This document describes the cost and performance (i.e., technical and environmental) characteristics of six central station energy alternatives: (1) conventional coal-fired powerplant; (2) conventional light water reactor (LWR); (3) combined cycle powerplant with low-Btu gasifiers; (4) liquid metal fast breeder reactor (LMFBR); (5) photovoltaic system without storage; and (6) fusion reactor.

  10. McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia

    PubMed Central

    2012-01-01

    Fibrous dysplasia (FD) is sometimes accompanied by extraskeletal manifestations that can include any combination of café-au-lait macules, hyperfunctioning endocrinopathies, such as gonadotropin-independent precocious puberty, hyperthyroidism, growth hormone excess, FGF23-mediated renal phosphate wasting, and/or Cushing syndrome, as well as other less common features. The combination of any of these findings, with or without FD, is known as McCune-Albright syndrome (MAS). The broad spectrum of involved tissues and the unpredictable combination of findings owe to the fact that molecular defect is due to dominant activating mutations in the widely expressed signaling protein, Gsα, and the fact these mutations arises sporadically, often times early in development, prior to gastrulation, and can distribute across many or few tissues. The complexity can be mastered by a systematic screening of potentially involved tissues and cognizance that the pattern of involved tissues is established, to some degree, in utero. Thorough testing allows the clinician to establish, often times at presentation, the full extent of the disease, and importantly as well what tissues are unaffected. Treatment and follow-up can then be focused on affected systems and a meaningful prognosis can be offered to the patient and family. The authors outline screening and treatment strategies that allow for effective management of the extraskeletal manifestations of FD. PMID:22640971

  11. McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia.

    PubMed

    Collins, Michael T; Singer, Frederick R; Eugster, Erica

    2012-05-24

    Fibrous dysplasia (FD) is sometimes accompanied by extraskeletal manifestations that can include any combination of café-au-lait macules, hyperfunctioning endocrinopathies, such as gonadotropin-independent precocious puberty, hyperthyroidism, growth hormone excess, FGF23-mediated renal phosphate wasting, and/or Cushing syndrome, as well as other less common features. The combination of any of these findings, with or without FD, is known as McCune-Albright syndrome (MAS). The broad spectrum of involved tissues and the unpredictable combination of findings owe to the fact that molecular defect is due to dominant activating mutations in the widely expressed signaling protein, Gsα, and the fact these mutations arises sporadically, often times early in development, prior to gastrulation, and can distribute across many or few tissues.The complexity can be mastered by a systematic screening of potentially involved tissues and cognizance that the pattern of involved tissues is established, to some degree, in utero. Thorough testing allows the clinician to establish, often times at presentation, the full extent of the disease, and importantly as well what tissues are unaffected. Treatment and follow-up can then be focused on affected systems and a meaningful prognosis can be offered to the patient and family. The authors outline screening and treatment strategies that allow for effective management of the extraskeletal manifestations of FD.

  12. McCune-Albright syndrome revealed by hyperthyroidism at advanced age.

    PubMed

    Elhaï, Muriel; Meunier, Marine; Kahan, André; Cormier, Catherine

    2011-12-01

    We report a case of a 38-year-old woman admitted to our service for diagnosis of osteolytic lesions. She suffered from back, lumbar and costal pain at the time a hyperthyroidism, related to multinodular goiter, was diagnosed. The pain remained despite the cure of hyperthyroidism. Cutaneous examination revealed café au lait skin spots. Analysis of the phosphocalcic metabolism allowed the diagnosis of phosphate diabetes. X-ray showed lytic lesions involving the ribs with thinning of the cortex and vertebral fractures of the dorsal spine. The computed tomography revealed lytic lesions with a typical "ground glass" appearance involving the spine, ribs, sternum, iliac bones and sacrum. The presence of this clinical triad allowed the diagnosis of McCune-Albright syndrome (MAS). The treatment consisted in vitamin D supplementation, and high doses of both oral phosphate and calcitriol to treat the phosphate diabetes as well as cycles of intravenous pamidronate administration to relieve bone pain. We report an uncommon case of the diagnosis of MAS at an advanced age following hyperthyroidism. We believe that the disease was revealed by an increase in bone turnover due to hyperthyroidism.

  13. USA paralympic team archer with McCune Albright Syndrome: a retrospective case report.

    PubMed

    Larsen, Nick; Nyland, John; Roberts, Craig S

    2010-01-01

    This retrospective case report describes a 22-year-old woman with McCune Albright Syndrome who was an archery Bronze Medalist at the 2008 USA Paralympic Games. The subject completed the Medical Outcome Survey Short Form-36 (SF-36) and the Hip Dysfunction and Osteoarthritis Score (HOOS). SF-36 scores met or exceeded those for National Collegiate Athletic Association (NCAA) female athletes, and age and gender matched USA norms for vitality, mental health and role emotional subscales. General health was lower than NCAA female athletes. Physical functioning, role: physical, bodily pain and social functioning subscale scores were lower than both comparison groups. HOOS symptom subscale scores revealed disabilities with walking (performed with crutches), hip abduction and stair climbing. Target archery does not require the lower extremity strength and motion required by many other sports. Identifying the ideal time to undergo total hip arthroplasty is difficult. As total hip arthroplasty becomes less invasive, more durable, with greater modular options, and with lower revision rates, more young patients will likely benefit. Serial SF-36 and HOOS surveys may help patients and surgeons better delineate symptom, functional limitation and disability changes across the early lifespan assisting surgical timing decisions while balancing existing function, quality of life values and near future technological advances.

  14. Bisphosphonate treatment of bone fibrous dysplasia in McCune-Albright syndrome.

    PubMed

    Lala, Roberto; Matarazzo, Patrizia; Andreo, Maria; Marzari, Daniela; Bellone, Jaele; Corrias, Andrea; de Sanctis, Carlo

    2006-05-01

    One of the main features of McCune-Albright syndrome is bone fibrous dysplasia (BFD) often associated with severe clinical outcomes, such as bone pain, bone deformities and pathological fractures. Medical treatment with bisphosphonates started 15 years ago. Recent trials in pediatric patients with BFD have shown encouraging results. We evaluated long-term efficacy and safety of pamidronate treatment of BFD in children and adolescents with MAS. The drug was administered at 4 month-1 year intervals according to alkaline phosphatase levels. The study included 14 patients (10 females and 4 males between the ages of 5.3 and 18.7 years) with moderate or severe BFD. Follow up lasted 1.9-9 years. Bone pain, fractures, deformities, and bone turnover markers were evaluated before every therapeutic course. The study shows the beneficial effects of long-term bisphosponate treatment on BFD lesions leading to reduced fracture rate and bone pain, and radiological evidence of long bone lesion healing.

  15. A Case of Atypical McCune-Albright Syndrome with Vaginal Bleeding

    PubMed Central

    Rostampour, Noushin; Hashemipour, Mahin; Kelishadi, Roya; Hovsepian, Silva; Hekmatnia, Ali

    2011-01-01

    Background McCune-Albright syndrome (MAS) is a rare non-inherited disorder characterized by the clinical triad of precocious puberty, cafe-au-lait skin lesions, and fibrous dysplasia of bone. Case Presentation We report a girl with MAS, presenting initially with vaginal bleeding at the age of 17 months. Ultrasonography revealed unilateral ovarian cysts and ureteral and ovarian enlargement. Considering the clinical and paraclinical findings, the patient diagnosed as a case of gonadotropin-independent precocious puberty was treated with medroxy-progestrone acetate (MPA) for three months. During the follow up, recurrent episodes of bleeding, ovarian activation and cyst formation, as well as breast size development were reported. At the age of 5.5 years, fibrous dysplasia was detected, which in coexistence with precocious puberty confirmed the diagnosis of MAS. The patient had no cafe-au-lait skin macles during follow up. Conclusion Considering that clinical manifestations of MAS appear later in the course of recurrent periods of ovarian activation and cyst formation, a careful clinical observation and follow up of patients is necessary and the diagnosis of MAS must be kept in mind in cases with gonadotropin-independent precocious puberty. PMID:23056821

  16. Parental origin of Gs alpha gene mutations in Albright's hereditary osteodystrophy.

    PubMed Central

    Wilson, L C; Oude Luttikhuis, M E; Clayton, P T; Fraser, W D; Trembath, R C

    1994-01-01

    Heterozygous mutations of the Gs alpha gene leading to reduced Gs alpha activity have been identified in patients with Albright's hereditary osteodystrophy (AHO). However, AHO may be associated with hormone resistance (pseudohypoparathyroidism type Ia, PHPIa) or a normal response (pseudo-pseudohypoparathyroidism, PPHP). As both disorders may occur within the same family, the relationship between Gs alpha genotype and phenotype remains unresolved. The AHO phenotype may be dependent upon the sex of the parent transmitting the Gs alpha mutation, perhaps through a gene imprinting mechanism. We have used an intragenic Gs alpha FokI polymorphism to determine the parental origin of Gs alpha gene mutations in sporadic and familial AHO. We now show that a de novo G-->A substitution at the exon 5 donor splice junction in a child with PPHP was paternally derived. Furthermore, in a female with PPHP, the Gs alpha abnormality was shown to be of paternal origin, while subsequent maternal processing and transmission resulted in PHPIa in two offspring. As transmission of PPHP has rarely been reported, determining parental origin of the disease allele in sporadic cases may provide insight into the mechanism of hormone resistance in AHO. Images PMID:7853365

  17. Space Station

    NASA Image and Video Library

    1991-01-01

    In 1982, the Space Station Task Force was formed, signaling the initiation of the Space Station Freedom Program, and eventually resulting in the Marshall Space Flight Center's responsibilities for Space Station Work Package 1.

  18. Property Analysis of the Real-Time Uncalibrated Phase Delay Product Generated by Regional Reference Stations and Its Influence on Precise Point Positioning Ambiguity Resolution.

    PubMed

    Zhang, Yong; Wang, Qing; Jiang, Xinyuan

    2017-05-19

    The real-time estimation of the wide-lane and narrow-lane Uncalibrated Phase Delay (UPD) of satellites is realized by real-time data received from regional reference station networks; The properties of the real-time UPD product and its influence on real-time precise point positioning ambiguity resolution (RTPPP-AR) are experimentally analyzed according to real-time data obtained from the regional Continuously Operating Reference Stations (CORS) network located in Tianjin, Shanghai, Hong Kong, etc. The results show that the real-time wide-lane and narrow-lane UPD products differ significantly from each other in time-domain characteristics; the wide-lane UPDs have daily stability, with a change rate of less than 0.1 cycle/day, while the narrow-lane UPDs have short-term stability, with significant change in one day. The UPD products generated by different regional networks have obvious spatial characteristics, thus significantly influencing RTPPP-AR: the adoption of real-time UPD products employing the sparse stations in the regional network for estimation is favorable for improving the regional RTPPP-AR up to 99%; the real-time UPD products of different regional networks slightly influence PPP-AR positioning accuracy. After ambiguities are successfully fixed, the real-time dynamic RTPPP-AR positioning accuracy is better than 3 cm in the plane and 8 cm in the upward direction.

  19. Next Generation Fast RF Interlock Module and ATCA Adapter for ILC High Availability RF Test Station Demonstration

    SciTech Connect

    Larsen, R

    2009-10-17

    High availability interlocks and controls are required for the ILC (International Linear Collider) L-Band high power RF stations. A new F3 (Fast Fault Finder) VME module has been developed to process both fast and slow interlocks using FPGA logic to detect the interlock trip excursions. This combination eliminates the need for separate PLC (Programmable Logic Controller) control of slow interlocks. Modules are chained together to accommodate as many inputs as needed. In the next phase of development the F3's will be ported to the new industry standard ATCA (Advanced Telecom Computing Architecture) crate (shelf) via a specially designed VME adapter module with IPMI (Intelligent Platform Management Interface). The goal is to demonstrate auto-failover and hot-swap for future partially redundant systems.

  20. Low-level radioactive waste from nuclear power generating stations: Characterization, classification and assessment of activated metals and waste streams

    SciTech Connect

    Thomas, V.W.; Robertson, D.E.; Thomas, C.W.

    1993-02-01

    Since the enactment of 10 CFR Part 61, additional difficult-to-measure long-lived radionuclides, not specified in Tables 1 2 of Part 61, have been identified (e.g., {sup 108m}Ag, {sup 93}Mo, {sup 36}Cl, {sup 10}Be, {sup 113m}Cd, {sup 121m}Sn, {sup 126}Sn, {sup 93m}Nb) that may be of concern in certain types of waste. These nuclides are primarily associated with activated metal and perhaps other nuclear power low-level waste (LLW) being sent to disposal facilities. The concentration of a radionuclide in waste materials is normally determined by direct measurement or by indirect calculational methods, such as using a scaling factor to relate inferred concentration of a difficult-to-measure radionuclide to another that is easily measured. The total disposal site inventory of certain difficult-to-measure radionuclides (e.g., {sup 14}C, {sup 129}I, and {sup 99}Tc) often control the total quantities of radioactive waste permitted in LLW burial facilities. Overly conservative scaling factors based on lower limits of detection (LLD), often used in the nuclear power industry to estimate these controlling nuclides, could lead to premature closure of a disposal facility. Samples of LLW (Class B and C activated metals [AM] and other waste streams) are being collected from operating nuclear power stations and analyzed for radionuclides covered in 10 CFR Part 61 and the additional difficult-to-measure radionuclides. This analysis will enhance the NRC`s understanding of the distribution and projected quantities of radionuclides within AM and LLW streams from commercial nuclear power stations. This research will also provide radiological characterization of AM specimens for others to use in leach-rate and lysimeter experiments to determine nuclide releases and subsequent movement in natural soil environments.

  1. Low-level radioactive waste from nuclear power generating stations: Characterization, classification and assessment of activated metals and waste streams

    SciTech Connect

    Thomas, V.W.; Robertson, D.E.; Thomas, C.W.

    1993-02-01

    Since the enactment of 10 CFR Part 61, additional difficult-to-measure long-lived radionuclides, not specified in Tables 1 2 of Part 61, have been identified (e.g., [sup 108m]Ag, [sup 93]Mo, [sup 36]Cl, [sup 10]Be, [sup 113m]Cd, [sup 121m]Sn, [sup 126]Sn, [sup 93m]Nb) that may be of concern in certain types of waste. These nuclides are primarily associated with activated metal and perhaps other nuclear power low-level waste (LLW) being sent to disposal facilities. The concentration of a radionuclide in waste materials is normally determined by direct measurement or by indirect calculational methods, such as using a scaling factor to relate inferred concentration of a difficult-to-measure radionuclide to another that is easily measured. The total disposal site inventory of certain difficult-to-measure radionuclides (e.g., [sup 14]C, [sup 129]I, and [sup 99]Tc) often control the total quantities of radioactive waste permitted in LLW burial facilities. Overly conservative scaling factors based on lower limits of detection (LLD), often used in the nuclear power industry to estimate these controlling nuclides, could lead to premature closure of a disposal facility. Samples of LLW (Class B and C activated metals [AM] and other waste streams) are being collected from operating nuclear power stations and analyzed for radionuclides covered in 10 CFR Part 61 and the additional difficult-to-measure radionuclides. This analysis will enhance the NRC's understanding of the distribution and projected quantities of radionuclides within AM and LLW streams from commercial nuclear power stations. This research will also provide radiological characterization of AM specimens for others to use in leach-rate and lysimeter experiments to determine nuclide releases and subsequent movement in natural soil environments.

  2. Second by second prediction of solar power generation based on cloud shadow behavior estimation near a power station

    NASA Astrophysics Data System (ADS)

    Nomura, Ryohei; Harigai, Toru; Suda, Yoshiyuki; Takikawa, Hirofumi

    2017-01-01

    Photovoltaic (PV) power generation has a particular problem for grid cooperation in that output can fluctuate due to the shadows created by clouds. If we can grasp the behavior of cloud shadows beforehand, then it may be possible to forecast output fluctuations. In this study, we want to prove if it is possible to calculate power output variation from the accumulated cloud shadow data. Cloud shadow behavior was measured from the ground by photodiodes (PDs) and the cloud shadow vector was calculated from the position and time difference. The time from the calculated cloud shadow vector to the arrival of the cloud shadow and the power generation output was calculated and compared with the actual solar power generation output. Thus, we confirmed that we can predict power generation output from a high correlation of two outputs. We found that prediction is possible, with high precision, at a short distance.

  3. A case of craniofacial fibrous dysplasia associated with McCune-Albright syndrome lost to follow-up.

    PubMed

    Williams, Robert Gareth Michael

    2015-02-26

    McCune-Albright syndrome is a rare fibro-osseous syndrome characterised by a classic triad of fibrous dysplasia (FD), café-au-lait macules and various underlying endocrinopathies. This case report describes how a patient was rediagnosed by a general dental practitioner following attendance for a routine dental examination. The patient had been previously diagnosed with the condition 28 years earlier but no follow-up or monitoring of her condition had taken place. As a result, she was found to have several undiagnosed and untreated complications of the disease including FD of the mandible, optic neuropathy and potential thyroid involvement.

  4. Polyostotic Fibrous Dysplasia in McCune-Albright Syndrome Demonstrated on 68Ga-DOTATATE PET/CT.

    PubMed

    Hennessy, Grace; Shetty, Deepa; Loh, Han; Bui, Chuong; Le, Ken; Mansberg, Robert

    2016-12-01

    A 33-year-old woman with McCune-Albright syndrome was referred for a Ga-DOTATATE PET/CT study for evaluation and staging of a biopsy-proven pancreatic tail neuroendocrine tumor. The scan demonstrated intense focal octreopeptide uptake corresponding to the known neuroendocrine tumor at the pancreatic tail/splenic hilum. There was no evidence of octreopeptide-avid metastases. Diffuse octreopeptide uptake was demonstrated in multiple bones involving the right side of the skeleton. The concurrent CT demonstrated corresponding expansile lucent changes consistent with the known fibrous dysplasia.

  5. Differential diagnosis in young women with oligomenorrhea and the pseudo-pseudohypoparathyroidism variant of Albright's hereditary osteodystrophy.

    PubMed

    Halal, F; Van Dop, C; Lord, J

    1985-07-01

    Oligomenorrhea was the reason for consultation in three individuals (two sisters and one unrelated woman) with the pseudo-pseudohypoparathyroidism (PPHP) variant of Albright's hereditary osteodystrophy (AHO). All had short stature, Ullrich-Turner-like signs, acral anomalies typical of AHO/brachydactyly E, and hypogonadism. One of the three individuals also had reduced erythrocyte NS (a membrane nucleotide regulatory protein that is required for functional coupling of stimulatory hormone receptors and catalytic adenylate cyclase) activity as described in the pseudohypoparathyroidism variant of AHO. The differential diagnosis of young women with the PPHP phenotype is discussed with special reference to Ullrich-Turner syndrome, brachydactyly E, the "resistant ovary" syndrome, and acrodysostosis.

  6. A case of craniofacial fibrous dysplasia associated with McCune-Albright syndrome lost to follow-up

    PubMed Central

    Williams, Robert Gareth Michael

    2015-01-01

    McCune-Albright syndrome is a rare fibro-osseous syndrome characterised by a classic triad of fibrous dysplasia (FD), café-au-lait macules and various underlying endocrinopathies. This case report describes how a patient was rediagnosed by a general dental practitioner following attendance for a routine dental examination. The patient had been previously diagnosed with the condition 28 years earlier but no follow-up or monitoring of her condition had taken place. As a result, she was found to have several undiagnosed and untreated complications of the disease including FD of the mandible, optic neuropathy and potential thyroid involvement. PMID:25721837

  7. Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone.

    PubMed

    Bianco, P; Riminucci, M; Majolagbe, A; Kuznetsov, S A; Collins, M T; Mankani, M H; Corsi, A; Bone, H G; Wientroub, S; Spiegel, A M; Fisher, L W; Robey, P G

    2000-01-01

    Activating missense mutations of the GNAS1 gene, encoding the alpha subunit of the stimulatory G protein (Gs), have been identified in patients with the McCune-Albright syndrome (MAS; characterized by polyostotic fibrous dysplasia, café au lait skin pigmentation, and endocrine disorders). Because fibrous dysplasia (FD) of bone also commonly occurs outside of the context of typical MAS, we asked whether the same mutations could be identified routinely in non-MAS FD lesions. We analyzed a series of 8 randomly obtained, consecutive cases of non-MAS FD and identified R201 mutations in the GNAS1 gene in all of them by sequencing cDNA generated by amplification of genomic DNA using a standard primer set and by using a novel, highly sensitive method that uses a protein nucleic acid (PNA) primer to block amplification of the normal allele. Histologic findings were not distinguishable from those observed in MAS-related FD and included subtle changes in cell shape and collagen texture putatively ascribed to excess endogenous cyclic adenosine monophosphate (cAMP). Osteomalacic changes (unmineralized osteoid) were prominent in lesional FD bone. In an in vivo transplantation assay, stromal cells isolated from FD failed to recapitulate a normal ossicle; instead, they generated a miniature replica of fibrous dysplasia. These data provide evidence that occurrence of GNAS1 mutations, previously noted in individual cases of FD, is a common and perhaps constant finding in non-MAS FD. These findings support the view that FD, MAS, and nonskeletal isolated endocrine lesions associated with GNAS1 mutations represent a spectrum of phenotypic expressions (likely reflecting different patterns of somatic mosaicism) of the same basic disorder. We conclude that mechanisms underlying the development of the FD lesions, and hopefully mechanism-targeted therapeutic approaches to be developed, must also be the same in MAS and non-MAS FD.

  8. Generation of high-resolution wind fields from the dense meteorological station network WegenerNet in South-Eastern Austria

    NASA Astrophysics Data System (ADS)

    Schlager, Christoph; Kirchengast, Gottfried; Fuchsberger, Jürgen

    2016-04-01

    To investigate weather and climate on a local scale as well as for evaluating regional climate models (RCMs) the Wegener Center at the University of Graz established the long-term field experiment WegenerNet Feldbach region, a dense grid of 153 meteorological stations. The observations of these stations are managed by an automatic WegenerNet Processing system. This system includes a quality check of collected observations and a Data Product Generator (DPG), among other subsystems. Products already implemented in the DPG are gridded weather and climate products, generated from the main parameters temperature, precipitation and relative humidity (Kirchengast et. al., Bull. Amer. Meteor. Soc., 95, 227-242, 2014). Missing elements are gridded wind fields from wind observations. Wind is considered as one of the most difficult meteorological variables to model and depends on many different parameters such as topography and surface roughness. Therefore a simple interpolation can only be performed in case of uniform characteristics of landscape. The presentation introduces our method of generation of wind fields from near real-time observations of the WegenerNet. Purpose of this work is to provide a database with 3D wind fields in a high spatial and time resolution as addition to the existing products, for evaluating convection permitting climate models as well as investigating weather and climate on a local scale. Core of the application is the diagnostic California Meteorological Model (CALMET). This model computes 3D wind fields based on meteorological observational data, a digital elevation model and land use categories. The application generates the required input files from meteorological stations of the WegenerNet Feldbach region and triggers the start of the CALMET model with these input files. In a next step the modeled wind fields are stored automatically every 30 minutes with a spatial resolution of 100 x 100 m in the WegenerNet database. To verify the

  9. NASA Education Activities on the International Space Station: A National Laboratory for Inspiring, Engaging, Educating and Employing the Next Generation

    NASA Technical Reports Server (NTRS)

    Severance, Mark T.; Tate-Brown, Judy; McArthur, Cynthia L.

    2010-01-01

    The International Space Station (ISS) National Lab Education Project has been created as a part of the ISS National Lab effort mandated by the U.S. Congress The project seeks to expand ISS education of activities so that they reach a larger number of students with clear educational metrics of accomplishments. This paper provides an overview of several recent ISS educational payloads and activities. The expected outcomes of the project, consistent with those of the NASA Office of Education, are also described. NASA performs numerous education activities as part of its ISS program. These cover the gamut from formal to informal educational opportunities in grades Kindergarten to grade 12, Higher Education (undergraduate and graduate University) and informal educational venues (museums, science centers, exhibits). Projects within the portfolio consist of experiments performed onboard the ISS using onboard resources which require no upmass, payloads flown to ISS or integrated into ISS cargo vehicles, and ground based activities that follow or complement onboard activities. Examples include ground based control group experiments, flight or experiment following lesson plans, ground based activities involving direct interaction with ISS or ground based activities considering ISS resources in their solution set. These projects range from totally NASA funded to projects which partner with external entities. These external agencies can be: other federal, state or local government agencies, commercial entities, universities, professional organizations or non-profit organizations. This paper will describe the recent ISS education activities and discuss the approach, outcomes and metrics associated with the projects.

  10. McCune-Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas.

    PubMed

    Madsen, Helen; Borges, Manuel Thomas; Kerr, Janice M; Lillehei, Kevin O; Kleinschmidt-Demasters, B K

    2011-08-01

    McCune-Albright syndrome (MAS) is a postzygotic (non-germline) disorder characterized by polyostotic fibrous dysplasia, cafe-au-lait macules and hypersecretory endocrinopathies. A significant percentage of MAS patients have pituitary adenomas that are either growth hormone (GH) or mixed GH/prolactin (PRL)-producing. Surgical excision may be challenging-or even impossible-due to the associated severe fibrous dysplasia of the skull base. Treatment relies on an interdisciplinary, multi-modal approach from endocrinologists, neurosurgeons and radiation oncologists. We present two cases of women with MAS and GH-secreting pituitary adenomas, encountered in our 30-year experience with pituitary diseases. The first patient successfully underwent transsphenoidal surgical resection for a pituitary microadenoma in 1997 (at age 18) and again in 2009 for recurrent disease, with a significant reduction in IGF-1 level. Immunohistochemistry (IHC) and electron microscopy (EM), performed on both specimens, showed a mammosomatotroph adenoma with GH, PRL, alpha subunit (+) IHC, with increased fibrous bodies developing over the 13-year interval. Focal hyperplasia could be discerned. EM in 1997 showed an admixture of mammosomatotrophs, mature lactotrophs and somatotrophs, with a bimodal population identified in 2009. The second MAS patient had long-standing polyostotic fibrous dysplasia, but was only recently diagnosed with GH excess and a pituitary adenoma, at the age of 29 years. Surgical resection was not advised in this patient because of the massive obstructive skull-base fibrous dysplasia. Medical therapy was initiated with somatostatin analogues, although responses in both patients have been suboptimal to date. We review the literature on GH excess in MAS to highlight its surgical and medical challenges.

  11. Progressive osseous heteroplasia, as an isolated entity or overlapping with Albright hereditary osteodystrophy.

    PubMed

    Lin, Maria H; Numbenjapon, Nawaporn; Germain-Lee, Emily L; Pitukcheewanont, Pisit

    2015-07-01

    Progressive osseous heteroplasia (POH) is a condition of invasive heterotopic ossification. Reports of patients with mild POH with Albright hereditary osteodystrophy (AHO), specifically pseudohypoparathyroidism type Ia (PHP Ia) with hormonal resistance, suggest the possibility of a common molecular basis. GNAS has been implicated to account for overlapping features of POH and PHP Ia. Case 1: A 4-year-old boy with obesity, speech delay, and expanding subcutaneous masses on buttock/forearm. Physical exam revealed round facies and brachydactyly. Blood tests showed normal Ca, P, Mg, 25-OH vitamin D levels but elevated parathyroid hormone (PTH) and thyroid-stimulating hormone (TSH). Abdominal computed tomography (CT) showed areas with calcifications in the subcutaneous tissue, fat, and muscle. Pathology of excised tissue revealed ossifications. Genomic study revealed no GNAS mutation. He had POH and PHP Ia. Case 2: A 3-year-old boy with painful ossifications in the left lower extremity. Lab tests were notable for elevated PTH and high-normal TSH. The CT-scan showed subcutaneous/intramuscular calcifications. Genetic testing showed GNAS mutation in exon 12 [c.1024C>T (R342X)]. Patient had POH and PHP Ia. Case 3: A 9-year-old boy with knee pain and subcutaneous ossifications in back and upper/lower extremity, causing significantly limited joint mobility. Lab tests were normal. The CT-scan showed areas corresponding to subcutaneous/intramuscular ossifications throughout torso and extremities, consistent with POH. There was no GNAS mutation. Patients with heterotopic ossifications present with a wide spectrum of disease. Although GNAS-based mutations have been postulated to account for overlapping features of AHO and POH, normal DNA studies in certain patients with POH/AHO suggest that there may exist other molecular/epigenetic mechanisms explaining their overlapping features.

  12. Studies of aerosol formation in power plant plumes—II. Secondary aerosol formation in the Navajo generating station plume

    NASA Astrophysics Data System (ADS)

    Wilson, J. C.; McMurry, P. H.

    Aerosol and gas measurements were made with the University of Minnesota Mobile Laboratory (UMML) during the VISTTA program (26 June, 1979 to 13 July, 1979) near Page, Arizona. The UMML was stationed on Zilnez Mesa (36.79°N, 110.63°W, elevation 2,200 m) approx. 65 km east of the Navajo coal-hred power plant. Measurements were made both in and out of the power plant plume and were made during the day and night. Measured parameters included aerosol size distributions, Aitken nuclei count, ozone and sulfur dioxide concentrations, the aerosol light scattering coefficient and meteorological parameters including ultraviolet radiation intensity. Concentrations of NO and NO x were occasionally measured. Data show clear evidence of gas-to-particle conversion in the plume with aerosol volume being added in the 0.01 μm-0.32 μm dia. range and new particles being formed. The observed excess aerosol volume depends strongly upon the SO 2 concentrations and the time of day with none observed in plume parcels which were not exposed to sunlight. This implies that the excess aerosol in the plume was secondary and was not due to primary particulate emissions from the stack. The fraction of sulfur appearing in the aerosol was inferred from the measurements of SO 2 concentrations and excess aerosol volume concentrations in the plume and was found to correlate with the time integral of the UV flux density received by the plume parcels since pollutant emission. The observed rate of SO 2 conversion was found to be 1.9 ± 0.8% h-1 at noon, with a diurnal average of 0.9 ± 0.4 % h-1.

  13. International Space Station (ISS)

    NASA Image and Video Library

    1995-04-17

    This computer generated scene of the International Space Station (ISS) represents the first addition of hardware following the completion of Phase II. The 8-A Phase shows the addition of the S-9 truss.

  14. Development of elements of the condition monitoring system of turbo generators of thermal power stations and nuclear power plants

    NASA Astrophysics Data System (ADS)

    Kumenko, A. I.; Kostyukov, V. N.; Kuz'minykh, N. Yu.; Boichenko, S. N.; Timin, A. V.

    2017-08-01

    The rationale is given for the improvement of the regulatory framework for the use of shaft sensors for the in-service condition monitoring of turbo generators and the development of control systems of shaft surfacing and misalignments of supports. A modern concept and a set of methods are proposed for the condition monitoring of the "shaft line-thrust bearing oil film-turbo generator supports" system elements based on the domestic COMPACS® technology. The system raw data are design, technology, installation, and operating parameters of the turbo generator as well as measured parameters of the absolute vibration of supports and mechanical quantities, relative displacements and relative vibration of the rotor teeth in accordance with GOST R 55263-2012. The precalculated shaft line assembly line in the cold state, the nominal parameters of rotor teeth positions on the dynamic equilibrium curve, the static and dynamic characteristics of the oil film of thrust bearings, and the shaft line stiffness matrix of unit support displacements have been introduced into the system. Using the COMPACS-T system, it is planned to measure positions and oscillations of rotor teeth, to count corresponding static and dynamic characteristics of the oil film, and the static and dynamic loads in the supports in real time. Using the obtained data, the system must determine the misalignments of supports and corrective alignments of rotors of coupling halves, voltages in rotor teeth, welds, and bolts of the coupling halves, and provide automatic conclusion if condition monitoring parameters correspond to standard values. A part of the methodological support for the proposed system is presented, including methods for determining static reactions of supports under load, the method for determining shaft line stiffness matrices, and the method for solving the inverse problem, i.e., the determination of the misalignments of the supports by measurements of rotor teeth relative positions in bearing

  15. Three intragenic suppressors of a GTPase-deficient allele of GNAS associated with McCune-Albright syndrome.

    PubMed

    Turcic, Kyle; Tobar-Rubin, Raquel; Janevska, Daniela; Carroll, Julie; Din, Eraj; Alvarez, Rebecca; Haick, Jennifer; Pals-Rylaarsdam, Robin

    2014-06-01

    Gain-of-function mutations in heterotrimeric G-protein α subunits are associated with a variety of human diseases. McCune-Albright syndrome (MAS) is caused by mutations in GNAS, the gene encoding Gs. Alterations at Arg201 significantly reduce the GTPase activity of the protein, rendering it constitutively active. In this study, we have constructed a library of random mutations in a constitutively active yeast GPA1 gene carrying a mutation homologous to the McCune-Albright allele (Arg297His). Intragenic suppressors found at sites with homology to the human Gs protein were tested for their ability to suppress the constitutive activity of an Arg201His mutation in Gs. Three intragenic suppressors, at Phe142, Arg231, and Leu266, were able to suppress elevated basal cAMP responses caused by Arg201His when expressed in HEK293 cells. A range of amino acid substitutions was introduced at each of these sites to investigate the chemical requirements for intragenic suppression. The ability of Gs proteins carrying the suppressor mutations alone to mediate receptor-induced cAMP production was measured. These results offer potential sites on Gs that could serve as drug targets for MAS therapies.

  16. Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.

    PubMed

    Salpea, Paraskevi; Stratakis, Constantine A

    2014-04-05

    Endocrine neoplasia syndromes feature a wide spectrum of benign and malignant tumors of endocrine and non-endocrine organs associated with other clinical manifestations. This study outlines the main clinical features, genetic basis, and molecular mechanisms behind two multiple endocrine neoplasia syndromes that share quite a bit of similarities, but one can be inherited whereas the other is always sporadic, Carney complex (CNC) and McCune-Albright (MAS), respectively. Spotty skin pigmentation, cardiac and other myxomas, and different types of endocrine tumors and other characterize Carney complex, which is caused largely by inactivating Protein kinase A, regulatory subunit, type I, Alpha (PRKAR1A) gene mutations. The main features of McCune-Albright are fibrous dysplasia of bone (FD), café-au-lait macules and precocious puberty; the disease is caused by activating mutations in the Guanine Nucleotide-binding protein, Alpha-stimulating activity polypeptide (GNAS) gene which are always somatic. We review the clinical manifestations of the two syndromes and provide an update on their molecular genetics.

  17. McCune Albright syndrome - association of fibrous dysplasia, café-au-lait skin spots and hyperthyroidism - case report.

    PubMed

    Raus, Iulian; Coroiu, Roxana Elena

    2016-01-01

    McCune-Albright syndrome is a rare sporadic disease characterized by bone fibrous dysplasia, café-au-lait skin spots and a variable association of hyperfunctional endocrine disorders. Fibrous dysplasia (FD), which can involve the craniofacial, axial, and appendicular skeleton, may range from an isolated, asymptomatic monostotic lesion to a severe disabling polyostotic disease involving the entire skeleton. A twenty-five-year old male patient presented to our clinic with recently developed heart palpitations. He had also been feeling pain in the right femur since he was younger, without any trauma history, leading to difficulties of ambulation and limping occasionally. His physical examination revealed café-au-lait spots with irregular borders and right testicular agenesis. Laboratory findings identified hyperthyroidism with hyperparathyroidism. Radiographs of the pelvis revealed multiple lytic lesions of the right femur and magnetic resonance imaging (MRI) characterized these lesions as specific to fibrous dysplasia of the bone, without any insufficiency fracture at this level. The association of café-au-lait skin spots with bone fibrous dysplasia, and hyperthyroidism in this patient suggested the diagnosis of McCune - Albright syndrome.

  18. Integrated gasification combined cycle power stations -- A view of the future and the relevance of the European project at Puertollano for electricity generators

    SciTech Connect

    Dartheney, A.; Jaud, P.; Davidson, B.; Hotchkiss, R.

    1994-12-31

    Electricity generators must adapt to changing constraints and opportunities. Changes in technology and business environment relative fuel prices, emission control technology and public expectations - have been considerable over the last decade. Future stability is unlikely. National Power (NP) is constructing and operating gas fired stations. Electricite de France (EDF) is retrofitting its fossil fired power stations and experimenting with new technologies such as circulating fluid bed boilers. Both are interested in other options for solid fuels. Capital cost, efficiency, operational and maintenance costs and environmental performance are important. Combustion technologies can incorporate gas cleaning during or after combustion. Gasification technologies permit gas cleaning before the main combustion stage. The relative merits of the two technologies are considered in this paper. Essential developments for widespread implementation are considered. The role of the European Integrated Gasification Combined Cycle project in advancing the gasification option is considered by utilities who are looking to apply the experience in future plant. Developments for future gasification based power plants are discussed.

  19. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station. Progress report, June-August 1982

    SciTech Connect

    Hoagland, K.E.

    1982-12-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Competition among the species is being analyzed. Adult populations of Teredo bartschi existed in both Oyster Creek and Forked River in the summer of 1982, but the species was rare. There was no large settlement of this or any other teredinid species in Barnegat Bay. Teredo navalis was the most common species in the monthly panels. The fouling community reached its maximum yearly diversity in June-July. There was a thermal effluent causing a ..delta..T of 3 to 4/sup 0/C during most of the summer, and salinity in Oyster Creek and Forked River was similar to that of Barnegat Bay. The lack of a shipworm outbreak in 1982 may be related to the low ..delta..T in summer, plus the lack of a thermal effluent in the preceding winter-spring period.

  20. Ecological studies of wood-boring bivalves and fouling organisms in the vicinity of the Oyster Creek Nuclear Generating Station. Final report, September 1976-December 1982

    SciTech Connect

    Hoagland, K.E.

    1983-10-01

    The species composition, distribution, and population dynamics of wood-boring bivalves were studied using wood test panels at 20 stations in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Physiological tolerances of three teredinid species were investigated in the laboratory and correlated with field values of temperature, salinity, siltation, precipitation, and plant operations. The interaction of boring and fouling organisms was examined. There is a definite correlation between the operation of the power plant and teredinid outbreaks. Increased salinity and water flow as well as temperature are responsible. After 1976, most of the damage in Oyster Creek was done by the introduced subtropical species Teredo bartschi. It can respond faster than native species to environmental change. Although Oyster Creek contributed larvae to neighboring parts of Barnegat Bay, its role as a breeding ground was limited. Some elements of the fouling community may be antagonistic to shipworm growth. Fouling was increased in both biomass and species richness in Oyster Creek when compared with creek controls, but the fouling community in Oyster Creek was less stable than that in other areas. Lower salinity limits for the teredinids were within the salinity range found in Oyster Creek but not within the range found in the control creeks. 71 references, 9 figures, 39 tables.

  1. Analysis of populations of boring and fouling organisms in the vicinity of the Oyster Creek Nuclear Generating Station. Quarterly progress report No. 12, Jun-Aug 79

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1980-07-01

    The growth, distribution, and species composition of marine borers (primarily shipworms) and fouling organisms are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 18 localities. Our most recent findings covering June-August, 1979, are that at least one subtropical species of the borer family Teredinidae, Teredo bartschi, continues to live in Oyster Creek and can breed in Forked River, although many die off in winter in Forked River and the species may have to recolonize. A few of the subtropical T. furcifera also survive in Oyster Creek but cause negligible damage at present, compared with T. bartschi. The summer, 1979, outbreak of T. bartschi in Oyster Creek was severe, causing nearly total destruction to wood panels. The breeding season for T. bartschi was the same as in 1978. Some fouling organisms were present in Oyster Creek that are absent in control creek stations due to low salinity.

  2. [Russian oxygen generation system "Elektron-VM": hydrogen content in electrolytically produced oxygen for breathing by International Space Station crews].

    PubMed

    Proshkin, V Yu; Kurmazenko, E A

    2014-01-01

    The article presents the particulars of hydrogen content in electrolysis oxygen produced aboard the ISS Russian segment by oxygen generator "Elektron-VM" (SGK) for crew breathing. Hydrogen content was estimated as in the course of SGK operation in the ISS RS, so during the ground life tests. According to the investigation of hydrogen sources, the primary path of H2 appearance in oxygen is its diffusion through the porous diaphragm separating the electrolytic-cell cathode and anode chambers. Effectiveness of hydrogen oxidation in the SGK reheating unit was evaluated.

  3. Development of a System to Generate Near Real Time Tropospheric Delay and Precipitable Water Vapor in situ at Geodetic GPS Stations, to Improve Forecasting of Severe Weather Events

    NASA Astrophysics Data System (ADS)

    Moore, A. W.; Bock, Y.; Geng, J.; Gutman, S. I.; Laber, J. L.; Morris, T.; Offield, D. G.; Small, I.; Squibb, M. B.

    2012-12-01

    We describe a system under development for generating ultra-low latency tropospheric delay and precipitable water vapor (PWV) estimates in situ at a prototype network of geodetic GPS sites in southern California, and demonstrating their utility in forecasting severe storms commonly associated with flooding and debris flow events along the west coast of North America through infusion of this meteorological data at NOAA National Weather Service (NWS) Forecast Offices and the NOAA Earth System Research Laboratory (ESRL). The first continuous geodetic GPS network was established in southern California in the early 1990s and much of it was converted to real-time (latency <1s) high-rate (1Hz) mode over the following decades. GPS stations are multi-purpose and can also provide estimates of tropospheric zenith delays, which can be converted into mm-accuracy PWV using collocated pressure and temperature measurements, the basis for GPS meteorology (Bevis et al. 1992, 1994; Duan et al. 1996) as implemented by NOAA with a nationwide distribution of about 300 GPS-Met stations providing PW estimates at subhourly resolution currently used in operational weather forecasting in the U.S. We improve upon the current paradigm of transmitting large quantities of raw data back to a central facility for processing into higher-order products. By operating semi-autonomously, each station will provide low-latency, high-fidelity and compact data products within the constraints of the narrow communications bandwidth that often occurs in the aftermath of natural disasters. The onsite ambiguity-resolved precise point positioning solutions are enabled by a power-efficient, low-cost, plug-in Geodetic Module for fusion of data from in situ sensors including GPS and a low-cost MEMS meteorological sensor package. The decreased latency (~5 minutes) PW estimates will provide the detailed knowledge of the distribution and magnitude of PW that NWS forecasters require to monitor and predict severe winter

  4. Multiple-Station Observation of Frequency Dependence and Polarization Characteristics of ELF/VLF waves generated via Ionospheric Modification

    NASA Astrophysics Data System (ADS)

    Maxworth, A. S.; Golkowski, M.; Cohen, M.; Moore, R. C.

    2014-12-01

    Generation of Extremely Low Frequency (ELF) and Very Low Frequency (VLF) signals through ionospheric modification has been practiced for many years. Heating the lower ionosphere with high power HF waves allows for modulation of natural current systems. Our experiments were carried out at the High Frequency Active Auroral Research Program (HAARP) facility in Alaska, USA. In this experiment, the ionosphere was heated with a vertical amplitude modulating signal and the modulation frequency was changed sequentially within an array of 40 frequencies followed by a frequency ramp. The observed magnetic field amplitude and polarization of the generated ELF/VLF signals were analyzed for multiple sites and as a function of modulation frequency. Our three observation sites: Chistochina, Paxson and Paradise are located within 36km (azimuth 47.7°), 50.2km (azimuth -20°) and 99km (azimuth 80.3°) respectively. We show that the peak amplitudes observed as a function of frequency result from vertical resonance in the Earth-ionosphere waveguide and can be used to diagnose the D-region profile. Polarization analysis showed that out of the three sites Paxson shows the highest circularity in the magnetic field polarization, compared to Chistochina and Paradise which show highly linear polarizations. The experimental results were compared with a theoretical simulation model results and it was clear that in both cases, the modulated Hall current dominates the observed signals at Chistochina and Paradise sites and at Paxson there is an equal contribution from Hall and Pedersen currents. The Chistochina site shows the highest magnetic field amplitudes in both experimental and simulation environments. Depending upon the experimental and simulation observations at the three sites, a radiation pattern for the HAARP ionospheric heater can be mapped

  5. Ecological studies of wood-boring bivalves in the vicinity of the Oyster Creek Nuclear Generating Station: progress report June-August 1981. Quarterly progress report 1 Jun-31 Aug 81

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1982-01-01

    The species composition, distribution, and population dynamics of wood-boring bivalves are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 12 stations. Physiological tolerances of 3 species are also under investigation in the laboratory. Competition among the species is being analyzed. In the summer of 1981, Teredo bartschi occurred in large numbers at one station in Oyster Creek, but did not appear in significant numbers in Forked River.

  6. 78 FR 45990 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ...The U.S. Nuclear Regulatory Commission (NRC) is granting both an exemption to allow a departure from the certification information of Tier 1 of the generic design control document (DCD) and is issuing License Amendment No. 8 to Combined Licenses (COL), NPF-91 and NPF-92. The COLs were issued to Southern Nuclear Operating Company, Inc., and Georgia Power Company, Oglethorpe Power Corporation, Municipal Electric Authority of Georgia, and the City of Dalton, Georgia (the licensee); for construction and operation of the Vogtle Electric Generating Plant (VEGP), Units 3 and 4, located in Burke County, Georgia. The amendment requests to revise the design of the bracing used to support the Turbine Building structure. This request requires changing Tier 1 information found in the Design Description portion of Updated Final Safety Analysis Report (UFSAR) Section 3.3, ``Buildings.'' The granting of the exemption allows the changes to Tier 1 information asked for in the amendment. Because the acceptability of the exemption was determined in part by the acceptability of the amendment, the exemption and amendment are being issued concurrently.

  7. Environmental radiological studies conducted during 1986 in the vicinity of the Rancho Seco Nuclear Power Generating Station

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Brunk, J.L.; Jokela, T.A.

    1987-03-01

    This report summarizes the information compiled in 1986 for our assessment of the environmental impact of radionuclides discharged with aqueous releases from the Rancho Seco Nuclear Power Generating Plant. In October 1984, a liquid-effluent control program was initiated that significantly reduced the quantities of radionuclides discharged with liquid waste from the plant. However, results from our sampling program in 1986 indicate that previously discharged radionuclides persist in the downstream environment and are found in many aquatic dietary components although at concentrations much lower than those measured in 1984 and 1985. The greatly reduced activities in the dietary components from the aquatic environment attest to the effectiveness of the liquid-effluent control program. Concentrations in the flesh of fish from the creeks have decreased over time and with distance from the plant outfall. The mean concentration of /sup 137/Cs in fish collected from Laguna Creek at locations more than 7.5 km from Rancho Seco is now comparable to the concentration determined in fresh-water fish randomly selected from Chicago, Illinois, markets. By August 1986, the mean concentration of /sup 137/Cs in the flesh of bluegill had fallen to 7% of the concentration measured in fish from comparable locations in 1984 and was 30% of the mean concentration measured in these fish during August 1985. Stable potassium in the water plays a major role in the accumulation of /sup 137/Cs by fish. Concentrations of /sup 137/Cs in the surface sections of creek sediments also declined between the end of 1984 and 1986 with an effective half-life of approximately 2 y. Surface soils collected around a perimeter 11 km from Rancho Seco and from ranchlands closer to the plant showed only concentrations of /sup 137/Cs originating from global fallout. Soils previously irrigated with Clay Creek water retain levels of both /sup 134/Cs and /sup 137/Cs.

  8. Evaluation of a main steam line break with induced, multiple tube ruptures: A comparison of NUREG 1477 (Draft) and transient methodologies Palo Verde Nuclear Generating Station

    SciTech Connect

    Parrish, K.R.

    1995-09-01

    This paper presents the approach taken to analyze the radiological consequences of a postulated main steam line break event, with one or more tube ruptures, for the Palo Verde Nuclear Generating Station. The analysis was required to support the restart of PVNGS Unit 2 following the steam generator tube rupture event on March 14, 1993 and to justify continued operation of Units 1 and 3. During the post-event evaluation, the NRC expressed concern that Unit 2 could have been operating with degraded tubes and that similar conditions could exist in Units 1 and 3. The NRC therefore directed that a safety assessment be performed to evaluate a worst case scenario in which a non-isolable main steam line break occurs inducing one or more tube failures in the faulted steam generator. This assessment was to use the generic approach described in NUREG 1477, Voltage-Based Interim Plugging Criteria for Steam Generator Tubes - Task Group Report. An analysis based on the NUREG approach was performed but produced unacceptable results for off-site and control room thyroid doses. The NUREG methodology, however, does not account for plant thermal-hydraulic transient effects, system performance, or operator actions which could be credited to mitigate dose consequences. To deal with these issues, a more detailed analysis methodology was developed using a modified version of the Combustion Engineering Plant Analysis Code, which examines the dose consequences for a main steam line break transient with induced tube failures for a spectrum equivalent to 1 to 4 double ended guillotine U-tube breaks. By incorporating transient plant system responses and operator actions, the analysis demonstrates that the off-site and control room does consequences for a MSLBGTR can be reduced to acceptable limits. This analysis, in combination with other corrective and recovery actions, provided sufficient justification for continued operation of PVNGS Units 1 and 3, and for the subsequent restart of Unit 2.

  9. Evaluation test on a landfill gas-fired turbine at the Los Angeles County Sanitation District's Puente Hill Landfill Electric Generation Station. Air pollution test report

    SciTech Connect

    Not Available

    1986-07-01

    A cooperative test program was conducted from February 25 through February 27, 1986 by Air Resources Board (ARB) and South Coast Air Quality Management District (SCAQMD) staff to evaluate the gaseous constituents from untreated landfill gas used to fuel a turbine and the emissions from that turbine located at the Los Angeles County Sanitation District's Puente Hills Electric Generating Station. The turbine was fueled with gases generated by the anaerobic decomposition of buried refuse at the Los Angeles County Sanitation District's Puente Hills Landfill. Emissions of criteria pollutant as determined from ARB test data are reported. Mass flow rates and destruction and removal efficiencies (DRE) of non-criteria pollutant compounds determined at the stack from SCQAMD bag-sample test data and mass-flow rates and DRE's for chlorinated and aromatic compounds determined from data from ARB resin samples are presented. Destruction and removal efficiencies based on mass-flow rates for chlorinated compounds ranged from 17 to 99+ percent and for aromatic compounds ranged from negative to 99+ percent. The possible formation of the compounds - chlorinated dioxins, furans, and polychlorinated biphenyls - was considered and samples were taken for analyses for these compounds. Dioxins, furans, and polychlorinated biphenyls were not detected in the inlet nor the outlet gas stream samples.

  10. [STEM on Station Education

    NASA Technical Reports Server (NTRS)

    Lundebjerg, Kristen

    2016-01-01

    The STEM on Station team is part of Education which is part of the External Relations organization (ERO). ERO has traditional goals based around BHAG (Big Hairy Audacious Goal). The BHAG model is simplified to a saying: Everything we do stimulates actions by others to advance human space exploration. The STEM on Station education initiate is a project focused on bringing off the earth research and learning into classrooms. Educational resources such as lesson plans, activities to connect with the space station and STEM related contests are available and hosted by the STEM on Station team along with their partners such as Texas Instruments. These educational activities engage teachers and students in the current happenings aboard the international space station, inspiring the next generation of space explorers.

  11. Space Station

    NASA Image and Video Library

    1972-01-01

    This is an artist's concept of a modular space station. In 1970 the Marshall Space Flight Center arnounced the completion of a study concerning a modular space station that could be launched by the planned-for reusable Space Shuttle. The study envisioned a space station composed of cylindrical sections 14 feet in diameter and of varying lengths joined to form any one of a number of possible shapes. The sections were restricted to 14 feet in diameter and 58 feet in length to be consistent with a shuttle cargo bay size of 15 by 60 feet. Center officials said that the first elements of the space station could be in orbit by about 1978 and could be manned by three or six men. This would be an interim space station with sections that could be added later to form a full 12-man station by the early 1980s.

  12. Space station

    NASA Technical Reports Server (NTRS)

    Stewart, Donald F.; Hayes, Judith

    1989-01-01

    The history of American space flight indicates that a space station is the next logical step in the scientific pursuit of greater knowledge of the universe. The Space Station and its complement of space vehicles, developed by NASA, will add new dimensions to an already extensive space program in the United States. The Space Station offers extraordinary benefits for a comparatively modest investment (currently estimated at one-ninth the cost of the Apollo Program). The station will provide a permanent multipurpose facility in orbit necessary for the expansion of space science and technology. It will enable significant advancements in life sciences research, satellite communications, astronomy, and materials processing. Eventually, the station will function in support of the commercialization and industrialization of space. Also, as a prerequisite to manned interplanetary exploration, the long-duration space flights typical of Space Station missions will provide the essential life sciences research to allow progressively longer human staytime in space.

  13. Space Station

    NASA Technical Reports Server (NTRS)

    Anderton, D. A.

    1985-01-01

    The official start of a bold new space program, essential to maintain the United States' leadership in space was signaled by a Presidential directive to move aggressively again into space by proceeding with the development of a space station. Development concepts for a permanently manned space station are discussed. Reasons for establishing an inhabited space station are given. Cost estimates and timetables are also cited.

  14. Pituitary and ovarian abnormalities demonstrated by CT and ultrasound in children with features of the McCune-Albright syndrome

    SciTech Connect

    Rieth, K.G.; Comite, F.; Shawker, T.H.; Cutler, G.B. Jr.

    1984-11-01

    In a random series of 97 children referred to the National Institutes of Health with a presumptive diagnosis of precocious puberty, eight girls were found to have features of the McCune-Albright syndrome, including fibrous dysplasia of bone and/or skin lesions resembling cafe au lait spots. Radiographic evaluation of these patients included computed tomography of the head and pelvic ultrasound. The pituitary glands were suspicious for abnormality in five of the eight girls. Seven girls underwent pelvic ultrasound, and in all of them the ovaries were considered to be abnormal for their chronological age; in addition, two had functional ovarian cysts. The role of diagnostic radiological studies in the diagnosis of this syndrome is discussed.

  15. Microbial Challenge Testing of Single Liquid Cathode Feed Water Electrolysis Cells for the International Space Station (ISS) Oxygen Generator Assembly (OGA)

    NASA Technical Reports Server (NTRS)

    Roy, Robert J.; Wilson, Mark E.; Diderich, Greg S.; Steele, John W.

    2011-01-01

    The International Space Station (ISS) Oxygen Generator Assembly (OGA) operational performance may be adversely impacted by microbiological growth and biofilm formation over the electrolysis cell membranes. Biofilms could hinder the transport of water from the bulk fluid stream to the membranes and increase the cell concentration overpotential resulting in higher cell voltages and a shorter cell life. A microbial challenge test was performed on duplicate single liquid-cathode feed water electrolysis cells to evaluate operational performance with increasing levels of a mixture of five bacteria isolated from ISS and Space Shuttle potable water systems. Baseline performance of the single water electrolysis cells was determined for approximately one month with deionized water. Monthly performance was also determined following each inoculation of the feed tank with 100, 1000, 10,000 and 100,000 cells/ml of the mixed suspension of test bacteria. Water samples from the feed tank and recirculating water loops for each cell were periodically analyzed for enumeration and speciation of bacteria and total organic carbon. While initially a concern, this test program has demonstrated that the performance of the electrolysis cell is not adversely impacted by feed water containing the five species of bacteria tested at a concentration measured as high as 1,000,000 colony forming units (CFU)/ml. This paper presents the methodologies used in the conduct of this test program along with the performance test results at each level of bacteria concentration.

  16. Microbial Challenge Testing of Single Liquid Cathode Feed Water Electrolysis Cells for the International Space Station (ISS) Oxygen Generator Assembly (OGA)

    NASA Technical Reports Server (NTRS)

    Diderich, Greg S.; Roy, Robert J.; Steele, John W.; Van Keuren, Steven P.; Wilson, Mark E.

    2010-01-01

    The International Space Station (ISS) Oxygen Generator Assembly (OGA) operational performance may be adversely impacted by microbiological growth and biofilm formation over the electrolysis cell membranes. Biofilms could hinder the transport of water from the bulk fluid stream to the membranes and increase the cell resistance resulting in higher cell voltages and a shorter cell life. A microbial challenge test was performed on duplicate single liquid cathode feed electrolyzer cells to evaluate operational performance with increasing levels of a mixture of five bacteria isolated from ISS and Space Shuttle potable water systems. Baseline performance of the single water electrolysis cells was determined for approximately one month with deionized water. Monthly performance was also determined following each inoculation of the feed tank with 100, 1000, 10,000 and 100,000 cells/ml of the mixed suspension of test bacteria. Water samples from the feed tank and recirculating water loops for each cell were periodically analyzed for enumeration and speciation of bacteria and total organic carbon. While initially a concern, this test program has demonstrated that the performance of the electrolysis cell is not adversely impacted by feed water containing the five species of bacteria tested at a concentration measured as high as 1,000,000 colony forming units (CFU)/ml. This paper presents the methodologies used in the conduct of this test program along with the performance test results at each level of bacteria concentration.

  17. The Current Status of the Space Station Biological Research Project: a Core Facility Enabling Multi-Generational Studies under Slectable Gravity Levels

    NASA Astrophysics Data System (ADS)

    Santos, O.

    2002-01-01

    The Space Station Biological Research Project (SSBRP) has developed a new plan which greatly reduces the development costs required to complete the facility. This new plan retains core capabilities while allowing for future growth. The most important piece of equipment required for quality biological research, the 2.5 meter diameter centrifuge capable of accommodating research specimen habitats at simulated gravity levels ranging from microgravity to 2.0 g, is being developed by NASDA, the Japanese space agency, for the SSBRP. This is scheduled for flight to the ISS in 2007. The project is also developing a multi-purpose incubator, an automated cell culture unit, and two microgravity habitat holding racks, currently scheduled for launch in 2005. In addition the Canadian Space Agency is developing for the project an insect habitat, which houses Drosophila melanogaster, and provides an internal centrifuge for 1 g controls. NASDA is also developing for the project a glovebox for the contained manipulation and analysis of biological specimens, scheduled for launch in 2006. This core facility will allow for experimentation on small plants (Arabidopsis species), nematode worms (C. elegans), fruit flies (Drosophila melanogaster), and a variety of microorganisms, bacteria, yeast, and mammalian cells. We propose a plan for early utilization which focuses on surveys of changes in gene expression and protein structure due to the space flight environment. In the future, the project is looking to continue development of a rodent habitat and a plant habitat that can be accommodated on the 2.5 meter centrifuge. By utilizing the early phases of the ISS to broadly answer what changes occur at the genetic and protein level of cells and organisms exposed to the ISS low earth orbit environment, we can generate interest for future experiments when the ISS capabilities allow for direct manipulation and intervention of experiments. The ISS continues to hold promise for high quality, long

  18. Prediction and modeling of the two-dimensional separation characteristic of a steam generator at a nuclear power station with VVER-1000 reactors

    NASA Astrophysics Data System (ADS)

    Parchevsky, V. M.; Guryanova, V. V.

    2017-01-01

    A computational and experimental procedure for construction of the two-dimensional separation curve (TDSC) for a horizontal steam generator (SG) at a nuclear power station (NPS) with VVER-reactors. In contrast to the conventional one-dimensional curve describing the wetness of saturated steam generated in SG as a function of the boiler water level at one, usually rated, load, TDSC is a function of two variables, which are the level and the load of SGB that enables TDSC to be used for wetness control in a wide load range. The procedure is based on two types of experimental data obtained during rated load operation: the nonuniformity factor of the steam load at the outlet from the submerged perforated sheet (SPS) and the dependence of the mass water level in the vicinity of the "hot" header on the water level the "cold" end of SG. The TDSC prediction procedure is presented in the form of an algorithm using SG characteristics, such as steam load and water level as the input and giving the calculated steam wetness at the output. The zoneby-zone calculation method is used. The result is presented in an analytical form (as an empirical correlation) suitable for uploading into controllers or other controls. The predicted TDSC can be used during real-time operation for implementation of different wetness control scenarios (for example, if the effectiveness is a priority, then the minimum water level, minimum wetness, and maximum turbine efficiency should be maintained; if safety is a priority, then the maximum level at the allowable wetness and the maximum water inventory should be kept), for operation of NPS in controlling the frequency and power in a power system, at the design phase (as a part of the simulation complex for verification of design solutions), during construction and erection (in developing software for personnel training simulators), during commissioning tests (to reduce the duration and labor-intensity of experimental activities), and for training.

  19. Space Station

    NASA Image and Video Library

    1952-01-01

    This is a von Braun 1952 space station concept. In a 1952 series of articles written in Collier's, Dr. Wernher von Braun, then Technical Director of the Army Ordnance Guided Missiles Development Group at Redstone Arsenal, wrote of a large wheel-like space station in a 1,075-mile orbit. This station, made of flexible nylon, would be carried into space by a fully reusable three-stage launch vehicle. Once in space, the station's collapsible nylon body would be inflated much like an automobile tire. The 250-foot-wide wheel would rotate to provide artificial gravity, an important consideration at the time because little was known about the effects of prolonged zero-gravity on humans. Von Braun's wheel was slated for a number of important missions: a way station for space exploration, a meteorological observatory and a navigation aid. This concept was illustrated by artist Chesley Bonestell.

  20. Tamoxifen-associated hirsutism: an unusual side effect in a 5-year-old girl with McCune-Albright syndrome.

    PubMed

    Kırmızıbekmez, Heves; Yesiltepe Mutlu, Rahime Gül; Dursun, Fatma; İşgüven, Şükriye Pınar

    2015-09-01

    Tamoxifen, a selective estrogen receptor modulator, has been used in the treatment of peripheral precocious puberty. A 5-year and 3-month-old girl, diagnosed with McCune-Albright syndrome, came in with abnormal hair growth approximately 2 months after the initiation of tamoxifen. The pattern of terminal hair on the skin following the administration of the drug and the exclusion of other causes suggested tamoxifen-induced hirsutism.

  1. Hepato-pancreato-biliary lesions are present in both Carney complex and McCune Albright syndrome: comments on P. Salpea and C. Stratakis.

    PubMed

    Gaujoux, Sébastien; Chanson, Philippe; Bertherat, Jérôme; Sauvanet, Alain; Ruszniewski, Philippe

    2014-01-25

    One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are one additional feature shared both by Carney complex and McCune Albright syndrome.

  2. Oral Alendronate Treatment for Severe Polyostotic Fibrous Dysplasia due to McCune-Albright Syndrome in a Child: A Case Report

    PubMed Central

    2010-01-01

    Polyostotic fibrous dysplasia (FD) associated to McCune-Albright Syndrome (MAS) often leads to fractures, deformities, and bone pain resulting in bad quality of life. Parenteral bisphosphonates have been used in children and adolescents to improve these symptoms with few adverse effects. We evaluated the response to oral Alendronate in a girl with severe MAS FD and observed improved quality of life with reduction of bone pain. PMID:20976302

  3. Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy.

    PubMed Central

    Levine, M A; Ahn, T G; Klupt, S F; Kaufman, K D; Smallwood, P M; Bourne, H R; Sullivan, K A; Van Dop, C

    1988-01-01

    Patients who have pseudohypoparathyroidism type I associated with Albright hereditary osteodystrophy commonly have a genetic deficiency of the alpha subunit of the G protein that stimulates adenylyl cyclase (alpha Gs) (ATP pyrophosphate-lyase, EC 4.6.1.1). To discover the molecular mechanism that causes alpha Gs deficiency in these patients, we examined eight kindreds with one or more members affected with Albright hereditary osteodystrophy or pseudohypoparathyroidism and alpha Gs deficiency. In these families, alpha Gs deficiency and the Albright hereditary osteodystrophy phenotype were transmitted together in a dominant inheritance pattern. Using a cDNA hybridization probe for alpha Gs, restriction analysis with several endonucleases showed no abnormalities of restriction fragments or gene dosage. RNA blot and dot blot analysis of total RNA from cultured fibroblasts obtained from the patients revealed approximately equal to 50% reduced mRNA levels for alpha Gs in affected members of six of the pedigrees but normal levels in affected members of the two other pedigrees, compared to mRNA levels in fibroblasts from unaffected individuals. By contrast, mRNA levels encoding the alpha subunit of the G protein that inhibits adenylyl cyclase were not altered. Our findings suggest that several molecular mechanisms produce alpha Gs deficiency in patients with pseudohypoparathyroidism type Ia and that major gene rearrangements or deletions are not a common cause for alpha Gs deficiency in pseudohypoparathyroidism type I. Images PMID:2829196

  4. Space Station

    NASA Image and Video Library

    1969-01-01

    This picture illustrates a concept of a 33-Foot-Diameter Space Station Leading to a Space Base. In-house work of the Marshall Space Flight Center, as well as a Phase B contract with the McDornel Douglas Astronautics Company, resulted in a preliminary design for a space station in 1969 and l970. The Marshall-McDonnel Douglas approach envisioned the use of two common modules as the core configuration of a 12-man space station. Each common module was 33 feet in diameter and 40 feet in length and provided the building blocks, not only for the space station, but also for a 50-man space base. Coupled together, the two modules would form a four-deck facility: two decks for laboratories and two decks for operations and living quarters. Zero-gravity would be the normal mode of operation, although the station would have an artificial gravity capability. This general-purpose orbital facility was to provide wide-ranging research capabilities. The design of the facility was driven by the need to accommodate a broad spectrum of activities in support of astronomy, astrophysics, aerospace medicine, biology, materials processing, space physics, and space manufacturing. To serve the needs of Earth observations, the station was to be placed in a 242-nautical-mile orbit at a 55-degree inclination. An Intermediate-21 vehicle (comprised of Saturn S-IC and S-II stages) would have launched the station in 1977.

  5. Space Station

    NASA Image and Video Library

    1991-01-01

    This artist's concept depicts the Space Station Freedom as it would look orbiting the Earth, illustrated by Marshall Space Flight Center artist, Tom Buzbee. Scheduled to be completed in late 1999, this smaller configuration of the Space Station featured a horizontal truss structure that supported U.S., European, and Japanese Laboratory Modules; the U.S. Habitation Module; and three sets of solar arrays. The Space Station Freedom was an international, permanently marned, orbiting base to be assembled in orbit by a series of Space Shuttle missions that were to begin in the mid-1990's.

  6. Space Station

    NASA Image and Video Library

    1991-01-01

    This artist's concept depicts the Space Station Freedom as it would look orbiting the Earth; illustrated by Marshall Space Flight Center artist, Tom Buzbee. Scheduled to be completed in late 1999, this smaller configuration of the Space Station features a horizontal truss structure that supported U.S., European, and Japanese Laboratory Modules; the U.S. Habitation Module; and three sets of solar arrays. The Space Station Freedom was an international, permanently marned, orbiting base to be assembled in orbit by a series of Space Shuttle missions that were to begin in the mid-1990's.

  7. Stations Outdoors

    ERIC Educational Resources Information Center

    Madison, John P.; And Others

    1976-01-01

    Described is a program of outdoor education utilizing activity-oriented learning stations. Described are 13 activities including: a pond study, orienteering, nature crafts, outdoor mathematics, linear distance measurement, and area measurement. (SL)

  8. Space Station

    NASA Image and Video Library

    1970-01-01

    This is an illustration of the Space Base concept. In-house work of the Marshall Space Flight Center, as well as a Phase B contract with the McDornel Douglas Astronautics Company, resulted in a preliminary design for a space station in 1969 and l970. The Marshall-McDonnel Douglas approach envisioned the use of two common modules as the core configuration of a 12-man space station. Each common module was 33 feet in diameter and 40 feet in length and provided the building blocks, not only for the space station, but also for a 50-man space base. Coupled together, the two modules would form a four-deck facility: two decks for laboratories and two decks for operations and living quarters. Zero-gravity would be the normal mode of operation, although the station would have an artificial-gravity capability. This general-purpose orbital facility was to provide wide-ranging research capabilities. The design of the facility was driven by the need to accommodate a broad spectrum of activities in support of astronomy, astrophysics, aerospace medicine, biology, materials processing, space physics, and space manufacturing. To serve the needs of Earth observations, the station was to be placed in a 242-nautical-mile orbit at a 55-degree inclination. An Intermediate-21 vehicle (comprised of Saturn S-IC and S-II stages) would have launched the station in 1977.

  9. UMTS Network Stations

    NASA Astrophysics Data System (ADS)

    Hernandez, C.

    2010-09-01

    The weakness of small island electrical grids implies a handicap for the electrical generation with renewable energy sources. With the intention of maximizing the installation of photovoltaic generators in the Canary Islands, arises the need to develop a solar forecasting system that allows knowing in advance the amount of PV generated electricity that will be going into the grid, from the installed PV power plants installed in the island. The forecasting tools need to get feedback from real weather data in "real time" from remote weather stations. Nevertheless, the transference of this data to the calculation computer servers is very complicated with the old point to point telecommunication systems that, neither allow the transfer of data from several remote weather stations simultaneously nor high frequency of sampling of weather parameters due to slowness of the connection. This one project has developed a telecommunications infrastructure that allows sensorizadas remote stations, to send data of its sensors, once every minute and simultaneously, to the calculation server running the solar forecasting numerical models. For it, the Canary Islands Institute of Technology has added a sophisticated communications network to its 30 weather stations measuring irradiation at strategic sites, areas with high penetration of photovoltaic generation or that have potential to host in the future photovoltaic power plants connected to the grid. In each one of the stations, irradiance and temperature measurement instruments have been installed, over inclined silicon cell, global radiation on horizontal surface and room temperature. Mobile telephone devices have been installed and programmed in each one of the weather stations, which allow the transfer of their data taking advantage of the UMTS service offered by the local telephone operator. Every minute the computer server running the numerical weather forecasting models receives data inputs from 120 instruments distributed

  10. Power Station Design

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Kuljian Corporation provides design engineering and construction management services for power generating plants in more than 20 countries. They used WASP (Calculating Water and Steam Properties), a COSMIC program to optimize power station design. This enabled the company to substantially reduce lead time and software cost in a recent design project.

  11. International Space Station (ISS)

    NASA Image and Video Library

    1995-04-17

    International Cooperation Phase III: A Space Shuttle docked to the International Space Station (ISS) in this computer generated representation of the ISS in its completed and fully operational state with elements from the U.S., Europe, Canada, Japan, and Russia.

  12. 5. Conveyors 'C' through 'K' (built 1940) south of Station, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Conveyors 'C' through 'K' (built 1940) south of Station, looking northeast from hurricane barrier. - Manchester Street Generating Station, Conveyors, 460 Eddy Street, Providence, Providence County, RI

  13. Space Station

    NASA Image and Video Library

    1971-01-01

    This is an artist's concept of the Research and Applications Modules (RAM). Evolutionary growth was an important consideration in space station plarning, and another project was undertaken in 1971 to facilitate such growth. The RAM study, conducted through a Marshall Space Flight Center contract with General Dynamics Convair Aerospace, resulted in the conceptualization of a series of RAM payload carrier-sortie laboratories, pallets, free-flyers, and payload and support modules. The study considered two basic manned systems. The first would use RAM hardware for sortie mission, where laboratories were carried into space and remained attached to the Shuttle for operational periods up to 7 days. The second envisioned a modular space station capability that could be evolved by mating RAM modules to the space station core configuration. The RAM hardware was to be built by Europeans, thus fostering international participation in the space program.

  14. Space Station

    NASA Image and Video Library

    1986-08-01

    In response to President Reagan's directive to NASA to develop a permanent marned Space Station within a decade, part of the State of the Union message to Congress on January 25, 1984, NASA and the Administration adopted a phased approach to Station development. This approach provided an initial capability at reduced costs, to be followed by an enhanced Space Station capability in the future. This illustration depicts a configuration with enhanced capabilities. It builds on the horizontal boom and module pattern of the revised baseline. This configuration would feature dual keels, two vertical spines 105-meters long joined by upper and lower booms. The structure carrying the modules would become a transverse boom of a basically rectangular structure. The two new booms, 45-meters in length, would provide extensive accommodations for attached payloads, and would offer a wide field of view. Power would be increased significantly, with the addition if a 50-kW solar dynamic power system.

  15. Solar power station

    SciTech Connect

    Wenzel, J.

    1982-11-30

    Solar power station with semiconductor solar cells for generating electric power is described, wherein the semiconductor solar cells are provided on a member such as a balloon or a kite which carries the solar cells into the air. The function of the balloon or kite can also be fulfilled by a glider or airship. The solar power station can be operated by allowing the system to ascend at sunrise and descend at sunset or when the wind is going to be too strong in order to avoid any demage.

  16. Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas.

    PubMed

    Wood, Laura D; Noë, Michaël; Hackeng, Wenzel; Brosens, Lodewijk A A; Bhaijee, Feriyl; Debeljak, Marija; Yu, Jun; Suenaga, Masaya; Singhi, Aatur D; Zaheer, Atif; Boyce, Alison; Robinson, Cemre; Eshleman, James R; Goggins, Michael G; Hruban, Ralph H; Collins, Michael T; Lennon, Anne Marie; Montgomery, Elizabeth A

    2017-02-10

    McCune-Albright Syndrome (MAS) is a rare sporadic syndrome caused by post-zygotic mutations in the GNAS oncogene, leading to constitutional mosaicism for these alterations. Somatic activating GNAS mutations also commonly occur in several gastrointestinal and pancreatic neoplasms, but the spectrum of abnormalities in these organs in patients with MAS has yet to be systematically described. We report comprehensive characterization of the upper gastrointestinal tract in seven patients with MAS and identify several different types of polyps, including gastric heterotopia/metaplasia (7/7), gastric hyperplastic polyps (5/7), fundic gland polyps (2/7), and a hamartomatous polyp (1/7). In addition, one patient had an unusual adenomatous lesion at the gastroesophageal junction with high-grade dysplasia. In the pancreas, all patients had endoscopic ultrasound findings suggestive of intraductal papillary mucinous neoplasm (IPMN), but only two patients met the criteria for surgical intervention. Both of these patients had IPMNs at resection, one with low-grade dysplasia and one with high-grade dysplasia. GNAS mutations were identified in the majority of lesions analyzed, including both IPMNs and the adenomatous lesion from the gastroesophageal junction. These studies suggest that there is a broad spectrum of abnormalities in the gastrointestinal tract and pancreas in patients with MAS and that patients with MAS should be evaluated for gastrointestinal pathology, some of which may warrant clinical intervention due to advanced dysplasia.

  17. Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome.

    PubMed

    Alves, Cresio; Silva, Sheila Ferreira

    2012-01-01

    We report a long-term follow-up on the use of anastrozole in the treatment of peripheral precocious puberty (PP) in McCune-Albright syndrome (MAS). A girl, age 3 years and 9 months, was diagnosed with MAS due to PP, café-au-lait spots, and polyostotic fibrous dysplasia. Serum estradiol was elevated, and gonadotropins were suppressed. Pelvic ultrasound showed an enlarged uterus and a follicle cyst (13 mm) in the left ovary. Bone scintigraphy showed osteogenic lesions on the skull, humerus, tibia, and acetabulum. Bone age was 3 years and 5 months at the chronological age of 3 years. After 36 months of treatment with anastrozole (1 mg/day), there was suppression of breast growth, normalization of growth velocity and serum estradiol, and disappearance of ovarian cysts. However, there was increase in uterine volume, advancement of bone age, and two episodes of vaginal bleeding (18th and 24th months). This report shows the partial benefit of anastrozole in the treatment of peripheral PP of girls with MAS.

  18. Mineralization, alteration, and hydrothermal metamorphism of the ophiolite-hosted Turner-Albright sulfide deposit, southwestern Oregon

    USGS Publications Warehouse

    Zierenberg, R.A.; Shanks, Wayne C.; Seyfried, W.E.; Koski, R.A.; Strickler, M.D.

    1988-01-01

    The Turner-Albright sulfide deposit, part of the Josephine ophiolite, formed on and below the seafloor during Late Jurassic volcanism at a back arc spreading center. Ore fluids were probably localized by faults which were active on the seafloor at the time of sulfide deposition. The uppermost massive sulfide formed on the seafloor at hydrothermal vents. The bulk of the sulfide mineralization formed below the seafloor within olivine basalt hyaloclastite erupted near the time of mineralization. Infiltration of hydrothermal fluid into the hyaloclastite altered the rock. The fluid responsible for the hydrothermal alteration was evolved seawater with low pH and Mg and high Fe. The average value of sulfide and the difference between sulfide and contemporaneous seawater sulfate values are similar to ophiolite-hosted sulfide deposits in Cyprus. Mudstone and clinopyroxene basalt above the sulfide horizons were not altered by the ore-transporting hydrothermal fluid, but these rocks were hydrothermally metamorphosed by altered seawater heated by deep circulation into hot oceanic crust. This subseafloor metamorphism produced a mineral assemblage typical of prehnite-pumpellyite facies metamorphism. Exchange with altered seawater increased the whole-rock ??18O of the basalts to values of 9.4-11.2%. -from Authors

  19. Characterization of a de novo 43-bp deletion of the Gs[alpha] gene (GNAS1) in Albright hereditary osteodystrophy

    SciTech Connect

    Luttikhuis, M.E.M.O.; Trembath, R.C. ); Wilson, L.C. Institute of Child Health, London ); Leonard, J.V. )

    1994-05-15

    Albright hereditary osteodystrophy (AHO) is an autosomal dominant disorder characterized by short stature, obesity, mental retardation, subcutaneous calcification, and brachy-metaphalangia. Two distinct forms of AHO exist; pseudohypoparathyroidism type I (PHPI) and pseudopseudohypoparathyrodism (PPHP). The classification is dependent upon the presence or absence, respectively, of resistance to parathyroid and other hormones that bind to Gs-protein-coupled membrane receptors stimulating adenylyl cyclase. Gs is a heterotrimeric protein comprising [alpha], [beta], and [gamma]-subunits encoded by separate genes. Genomic DNA was isolated from peripheral leukocytes from 13 unrelated AHO patients. Exon 4 and flanking intronic sequence of GNAS1 were PCR amplified. A single PCR product corresponding to the expected 159-bp fragment was identified in 12 affected individuals with either PHPIa or PPHP. In patient 10285 an additional smaller fragment was detected but was not present in either of the unaffected parents. These two fragments were isolated from a 2% agarose gel. Direct sequencing of the smaller fragment revealed a 43-bp deletion comprising at least 35 hp of the 3[prime] end of exon 4 and the donor splice site of intron 4 and extending into the following intro. The 43-bp deletion would lead to a premature stop codon, 62 codons downstream of the deletion. The de novo mutation reported here is the largest deletion in the Gs[alpha] gene described so far for AHO patients.

  20. Unique skin changes in a case of Albright hereditary osteodystrophy caused by a rare GNAS1 mutation.

    PubMed

    Klaassens, M; Blom, E W; Schrander, J J P; Ris-Stalpers, C; Nieuwenhuijzen Kruseman, A C; van Steensel, M A M; Schrander-Stumpel, C T R M

    2010-03-01

    Albright hereditary osteodystrophy (AHO) is a syndrome of short stature, obesity, brachydactyly and subcutaneous calcifications with pseudohypoparathyroidism (PHP; leading to hypocalcaemia, hyperphosphataemia and elevated levels of parathyroid hormone, PTH). It was first described over 60 years ago. Since then, much has been learned about the aetiology of AHO which has been shown to be caused by heterozygous loss-of-function mutations within the GNAS1 gene. GNAS1 is subject to imprinting leading to phenotypic heterogeneity within kindreds with one mutation. Patients with AHO often present with symptoms of hypocalcaemia and/or with subcutaneous calcifications. The latter is thought to be the typical skin abnormality in AHO. We describe a family with AHO and hormone resistance (PHP type Ia) resulting from a rare mutation in GNAS1. The proband presented with small subcutaneous calcifications in the helix of the right ear and concentrated in a sharply demarcated zone of subcutaneous and dermal hypoplasia. This abnormality has so far not been described in patients with AHO. We speculate on the mechanism of dermal hypoplasia and resistance to PTH and suggest that subcutanous or dermal hypoplasia might be another feature which can be present in patients with AHO.

  1. A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy.

    PubMed

    Weinstein, L S; Gejman, P V; de Mazancourt, P; American, N; Spiegel, A M

    1992-08-01

    Several heterozygous mutations within the gene encoding the alpha-subunit of Gs (GNAS1), the G protein that stimulates adenylyl cyclase, have been previously identified in patients with Albright hereditary osteodystrophy (AHO). We have now identified a fourth GNAS1 mutation from an AHO patient. Amplification by the polymerase chain reaction (PCR) of a genomic fragment encompassing GNAS1 exons 7 and 8 from one patient resulted in a product with aberrant migration on nondenaturing polyacrylamide and agarose gels. Direct DNA sequencing identified a 4-bp deletion in one allele of exon 7 encoding a frameshift with a premature stop codon. Analysis of lymphocyte RNA by reverse transcription-PCR and direct sequencing showed that the GNAS1 allele bearing the mutation is not expressed as mRNA. Consistent with this, Northern analysis revealed an approximate 50% deficiency in steady-state levels of GNAS1 mRNA. These findings further illustrate the heterogeneity of GNAS1 gene defects in AHO.

  2. Molecular analysis of the GNAS1 gene for the correct diagnosis of Albright hereditary osteodystrophy and pseudohypoparathyroidism.

    PubMed

    De Sanctis, Luisa; Romagnolo, Damiano; Olivero, Martina; Buzi, Fabio; Maghnie, Mohamad; Scirè, Giuseppe; Crino, Antonio; Baroncelli, Giampiero Igli; Salerno, Mariacarolina; Di Maio, Salvatore; Cappa, Marco; Grosso, Salvatore; Rigon, Franco; Lala, Roberto; De Sanctis, Carlo; Dianzani, Irma

    2003-05-01

    Pseudohypoparathyroidism (PHP) is a heterogeneous disease characterized by PTH resistance and classified as types Ia, Ib, Ic, and II, according to its different pathogenesis and phenotype. PHP-Ia patients show Gsalpha protein deficiency, PTH resistance, and typical Albright hereditary osteodystrophy (AHO). Heterozygous mutations in the GNAS1 gene encoding the Gsalpha protein have been identified both in PHP-Ia and in pseudopseudohypoparathyroidism (PPHP), a disorder with isolated AHO. A single GNAS1 mutation may be responsible for both PHP-Ia and PPHP in the same family when inherited from the maternal and the paternal allele, respectively, suggesting that GNAS1 is an imprinted gene. To evaluate whether molecular diagnosis is a useful tool to characterize AHO and PHP when testing for Gsalpha activity and PTH resistance is not available, we have performed GNAS1 mutational analysis in 43 patients with PTH resistance and/or AHO. Sequencing of the whole coding region of the GNAS1 gene identified 11 mutations in 18 PHP patients, eight of which have not been reported previously. Inheritance was ascertained in 13 cases, all of whom had PHP-Ia: the mutated alleles were inherited from the mothers, who had AHO (PPHP), consistent with the proposed imprinting mechanism. GNAS1 molecular analysis confirmed the diagnosis of PHP-Ia and PPHP in the mutated patients. Our results stress the usefulness of this approach to obtain a complete diagnosis, expand the GNAS1 mutation spectrum, and illustrate the wide mutation heterogeneity of PHP and PHP-Ia.

  3. Searching for Arg201 mutations in the GNAS1 gene in Italian patients with McCune-Albright syndrome.

    PubMed

    de Sanctis, Luisa; Romagnolo, Damiano; Greggio, Nella; Genitori, Lorenzo; Lala, Roberto; de Sanctis, Carlo

    2002-01-01

    McCune-Albright syndrome (MAS) is a rare disease caused by somatic postzygotic mutations at Arg201 in the GNAS1 gene that encodes for the Gsalpha protein. Arg201 mutations are gain-of-function mutations in affected tissues (including bone, skin, endocrine glands and other tissues) that result in the activation of cAMP. We used a polymerase chain reaction(PCR)-based technique for the selective enrichment and analysis of the Arg201 mutant allele in 27 different tissues from 24 Italian patients with one or more signs of MAS. Arg201 mutations were identified in 13 different tissues (48.1%) from 11 patients (45.8%). Mutation detection rates differed across the various types of tissue samples, and the mutation was not always found in every tissue sample from the same patient. To overcome problems in the analysis of mutations in somatic mosaicism, as occurs in MAS, a highly sensitive molecular technique should be applied, the most appropriate tissue source selected, and various affected tissues from the same patient analyzed.

  4. A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.

    PubMed

    Schwindinger, W F; Miric, A; Zimmerman, D; Levine, M A

    1994-10-14

    Albright hereditary osteodystrophy (AHO) is an autosomal-dominant disorder characterized by decreased expression of Gs alpha and widespread tissue resistance to hormones that activate adenylyl cyclase. We identified a single mutation, R385H, in the Gs alpha gene of a subject with AHO who had evidence for a dysfunctional Gs alpha protein. The R385H substitution is near the carboxyl terminus of the Gs alpha protein and is located five amino acids upstream of the R389P mutation that uncouples Gs alpha from cell surface receptors in the unc clone of S49 murine lymphoma. To test the biological activity of the R385H mutant, we transiently expressed wild type, R385H, and R389P Gs alpha cDNAs in COS-1 cells. Neither of the mutant Gs alpha proteins stimulated adenylyl cyclase in response to l-isoproterenol (1 to 30 microM). By contrast, both mutant Gs alpha proteins showed activation of adenylyl cyclase in response to forskolin (10 microM) and fluoroaluminate (10 mM). We propose that the R385H mutation produces a Gs alpha molecule that is unable to interact with hormone receptors and results in uncoupling of adenylyl cyclase from cell surface receptors. This uncoupling mutation represents a new type of molecular defect that can result in AHO.

  5. Pseudohypoparathyroidism type Ia. Albright hereditary osteodystrophy: a model for research on G protein-coupled receptors and genomic imprinting.

    PubMed

    Simon, A; Koppeschaar, H P; Roijers, J F; Höppener, J W; Lips, C J

    2000-03-01

    Pseudohypoparathyroidism type Ia (PHP Ia) is a hereditary endocrine disorder, characterised by resistance to parathyroid hormone (PTH), causing disturbance of calcium homeostasis, and to several other polypeptide hormones. Patients with PHP Ia exhibit a complex of somatic abnormalities, termed Albright hereditary osteodystrophy (AHO). Treatment with vitamin D derivatives alleviates symptoms of hypocalcemia and may prevent bone demineralisation. PTH, like many polypeptide hormones, exerts its effects via a G protein-coupled cell surface receptor. PHP Ia is caused by a heterozygous, inactivating mutation in the gene for the alpha-subunit of the Gs protein, which disrupts Gs-protein-coupled signal transduction pathways. Several mutations have been described. When the mutation is inherited from the mother, the offspring will develop PHP Ia, i.e., both hormonal resistance and somatic abnormalities. When the mutation is derived from the father, children will have normal hormone responses while exhibiting the somatic features of AHO; this form of the disorder is called pseudopseudohypoparathyroidism (PPHP). A combination of tissue-specific genomic imprinting and haploinsufficiency may explain the occurrence of PPHP, and the fact that not all Gs-mediated polypeptide hormone actions are affected equally. PHP may therefore serve as a model in studying the pleiotropic consequences of impaired Gs-mediated signal transduction.

  6. A case of McCune-Albright syndrome associated with pituitary GH adenoma: therapeutic process and autopsy.

    PubMed

    Liu, Fuyi; Li, Wenting; Yao, Yong; Li, Guilin; Yang, Yi; Dou, Wanchen; Zhong, Dingrong; Wang, Lin; Zhu, Xiangdong; Hu, Hua; Zhang, Jianmin; Wang, Renzhi; Chen, Gao

    2011-01-01

    McCune-Albright syndrome (MAS) is a clinical syndrome with low incidence, and its concurrence with pituitary GH adenoma is rare. Little of the history, treatment and outcome has been studied. Follow-up of a 37-year-old male patient of MAS associated with pituitary GH adenoma was performed continuously recording the disease development and the treatment process until death, after which an autopsy was performed. Radiation therapy (RT) efficaciously controlled GH hypersecretion, however, it may have been the cause of the malignant transformation of the dysplastic bone tissue, which eventually caused brain hernia and death; autopsy demonstrated that the cranium had significant thickening (as much as 10 cm), the pathological diagnosis was fibrous dysplasia of bone associated with chondrosarcoma; and undifferentiated chondrosarcoma with malignant fibrous histocytoma subtype in the sellar region; nodular goiter with the thyroid gland, one nodus was pathologically demonstrated as papillary carcinoma. GH adenoma, present in a patient with MAS, might be cured by RT; but the risk of malignant transformation of the dysplastic bone tissue in the field of irradiation make it controversial. Lessons from the case reported here told us that we should take great caution when recommending RT for patients like this.

  7. Observation Station

    ERIC Educational Resources Information Center

    Rutherford, Heather

    2011-01-01

    This article describes how a teacher integrates science observations into the writing center. At the observation station, students explore new items with a science theme and use their notes and questions for class writings every day. Students are exposed to a variety of different topics and motivated to write in different styles all while…

  8. Space Station

    NASA Image and Video Library

    1985-12-01

    Skylab's success proved that scientific experimentation in a low gravity environment was essential to scientific progress. A more permanent structure was needed to provide this space laboratory. President Ronald Reagan, on January 25, 1984, during his State of the Union address, claimed that the United States should exploit the new frontier of space, and directed NASA to build a permanent marned space station within a decade. The idea was that the space station would not only be used as a laboratory for the advancement of science and medicine, but would also provide a staging area for building a lunar base and manned expeditions to Mars and elsewhere in the solar system. President Reagan invited the international community to join with the United States in this endeavour. NASA and several countries moved forward with this concept. By December 1985, the first phase of the space station was well underway with the design concept for the crew compartments and laboratories. Pictured are two NASA astronauts, at Marshall Space Flight Center's (MSFC) Neutral Buoyancy Simulator (NBS), practicing construction techniques they later used to construct the space station after it was deployed.

  9. The Calern atmospheric turbulence station

    NASA Astrophysics Data System (ADS)

    Chabé, Julien; Ziad, Aziz; Fantéï-Caujolle, Yan; Aristidi, Éric; Renaud, Catherine; Blary, Flavien; Marjani, Mohammed

    2016-07-01

    From its long expertise in Atmospheric Optics, the Observatoire de la Côte d'Azur and the J.L. Lagrange Laboratory have equipped the Calern Observatory with a station of atmospheric turbulence measurement (CATS: Calern Atmospheric Turbulence Station). The CATS station is equipped with a set of complementary instruments for monitoring atmospheric turbulence parameters. These new-generation instruments are autonomous within original techniques for measuring optical turbulence since the first meters above the ground to the borders of the atmosphere. The CATS station is also a support for our training activities as part of our Masters MAUCA and OPTICS, through the organization of on-sky practical works.

  10. 35. SITE BUILDING 004 ELECTRIC POWER STATION CONTROL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. SITE BUILDING 004 - ELECTRIC POWER STATION - CONTROL ROOM OF ELECTRIC POWER STATION WITH DIESEL ENGINE POWERED ELECTRIC GENERATION EQUIPMENT IN BACKGROUND. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  11. 2. Conveyor 'N' (built ca. 1950) north of Station and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Conveyor 'N' (built ca. 1950) north of Station and connecting to South Street Station, looking northeast. - Manchester Street Generating Station, Conveyors, 460 Eddy Street, Providence, Providence County, RI

  12. Generations.

    PubMed

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  13. Space Station reference configuration description

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The data generated by the Space Station Program Skunk Works over a period of 4 months which supports the definition of a Space Station reference configuration is documented. The data were generated to meet these objectives: (1) provide a focal point for the definition and assessment of program requirements; (2) establish a basis for estimating program cost; and (3) define a reference configuration in sufficient detail to allow its inclusion in the definition phase Request for Proposal (RFP).

  14. ILRS Station Reporting

    NASA Technical Reports Server (NTRS)

    Noll, Carey E.; Pearlman, Michael Reisman; Torrence, Mark H.

    2013-01-01

    Network stations provided system configuration documentation upon joining the ILRS. This information, found in the various site and system log files available on the ILRS website, is essential to the ILRS analysis centers, combination centers, and general user community. Therefore, it is imperative that the station personnel inform the ILRS community in a timely fashion when changes to the system occur. This poster provides some information about the various documentation that must be maintained. The ILRS network consists of over fifty global sites actively ranging to over sixty satellites as well as five lunar reflectors. Information about these stations are available on the ILRS website (http://ilrs.gsfc.nasa.gov/network/stations/index.html). The ILRS Analysis Centers must have current information about the stations and their system configuration in order to use their data in generation of derived products. However, not all information available on the ILRS website is as up-to-date as necessary for correct analysis of their data.

  15. Population exposure to electromagnetic fields generated by radio base stations: evaluation of the urban background by using provisional model and instrumental measurements.

    PubMed

    Anglesio, L; Benedetto, A; Bonino, A; Colla, D; Martire, F; Saudino Fusette, S; d'Amore, G

    2001-01-01

    Electromagnetic radiation, which is used by broadcasting and mobile telephone systems to transmit information, permeates the city environment. In order to properly evaluate population exposure to electromagnetic fields, knowledge of their intensity and spectral components is necessary. In this study the results of radiofrequency field monitoring carried out in Torino, a large town located in the north-west of Italy are shown: the variation of the electromagnetic field strength is evaluated as a function of the height from the ground, the location in the urban area and the frequency. separating the contributions of the different sources (broadcasting antennas and radio base stations for mobile phones). Furthermore, the contribution of the radio base stations is theoretically evaluated, adding the emissions off all installations situated in Torino and examining the field strength maps calculated, considering the orography, for different heights. The theoretical values are also compared with those measured in the frequency range of mobile telephony emissions.

  16. Pseudohypoparathyroidism and GNAS epigenetic defects: clinical evaluation of albright hereditary osteodystrophy and molecular analysis in 40 patients.

    PubMed

    Mantovani, Giovanna; de Sanctis, Luisa; Barbieri, Anna Maria; Elli, Francesca M; Bollati, Valentina; Vaira, Valentina; Labarile, Pamela; Bondioni, Sara; Peverelli, Erika; Lania, Andrea G; Beck-Peccoz, Paolo; Spada, Anna

    2010-02-01

    The two main subtypes of pseudohypoparathyroidism (PHP), PHP-Ia and -Ib, are caused by mutations in GNAS exons 1-13 and methylation defects in the imprinted GNAS cluster, respectively. PHP-Ia patients show Albright hereditary osteodystrophy (AHO) and resistance toward PTH and additional hormones, whereas PHP-Ib patients do not have AHO, and hormone resistance appears to be limited to PTH and TSH. Recently, methylation defects have been detected in few patients with PHP and mild AHO, indicating a molecular overlap between the two forms. The aim of the study was to screen patients with clinically diagnosed PHP-Ia for methylation defects and to investigate the presence of correlations between the molecular findings and AHO severity. We investigated differential methylation of GNAS regions and STX16 microdeletions in genomic DNA from 40 patients with sporadic AHO and multihormone resistance, with no mutations in Gsalpha-coding GNAS exons. Molecular analysis showed GNAS cluster imprinting defects in 24 of the 40 patients analyzed. No STX16 deletion was detected. The presence of imprinting defects was not associated with the severity of AHO or with specific AHO signs. We report the largest series of the literature of patients with clinical AHO and multihormone resistance and no mutation in the Gsalpha gene. Our findings of frequent GNAS imprinting defects further confirm the existence of an overlap between molecular and clinical features of PHP-Ia and PHP-Ib and highlight the necessity of a new clinical classification of the disease that takes into account the recent knowledge on the molecular basis underlying these defects.

  17. Identification of two novel deletion mutations within the Gs alpha gene (GNAS1) in Albright hereditary osteodystrophy.

    PubMed

    Yu, D; Yu, S; Schuster, V; Kruse, K; Clericuzio, C L; Weinstein, L S

    1999-09-01

    Albright hereditary osteodystrophy (AHO) is a genetic disorder characterized by short stature, skeletal defects, and obesity. Within AHO kindreds, some affected family members have only the somatic features of AHO [pseudopseudohypoparathyroidism (PPHP)], whereas others have these features in association with resistance to multiple hormones that stimulate adenylyl cyclase within their target tissues [pseudohypoparathyroidism type Ia (PHP Ia)]. Affected members of most AHO kindreds (both those with PPHP and those with PHP Ia) have a partial deficiency of Gs alpha, the alpha-subunit of the G protein that couples receptors to adenylyl cyclase stimulation, and in a number of cases heterozygous loss of function mutations within the Gs alpha gene (GNAS1) have been identified. Using PCR with the attachment of a high melting domain (GC-clamp) and temperature gradient gel electrophoresis, two novel heterozygous frameshift mutations within GNAS1 were found in two AHO kindreds. In one kindred all affected members (both PHP Ia and PPHP) had a heterozygous 2-bp deletion in exon 8, whereas in the second kindred a heterozygous 2-bp deletion in exon 4 was identified in all affected members examined. In both cases the frameshift encoded a premature termination codon several codons downstream of the deletion. In the latter kindred affected members were previously shown to have decreased levels of GNAS1 messenger ribonucleic acid expression. These results further underscore the genetic heterogeneity of AHO and provides further evidence that PHP Ia and PPHP are two clinical presentations of a common genetic defect. Serial measurements of thyroid function in members of kindred 1 indicate that TSH resistance progresses with age and becomes more evident after the first year of life.

  18. McCune-Albright syndrome: a detailed pathological and genetic analysis of disease effects in an adult patient.

    PubMed

    Vasilev, Vladimir; Daly, Adrian F; Thiry, Albert; Petrossians, Patrick; Fina, Frederic; Rostomyan, Liliya; Silvy, Monique; Enjalbert, Alain; Barlier, Anne; Beckers, Albert

    2014-10-01

    McCune Albright syndrome (MAS) is a clinical association of endocrine and nonendocrine anomalies caused by postzygotic mutation of the GNAS1 gene, leading to somatic activation of the stimulatory α-subunit of G protein (Gsα). Important advances have been made recently in describing pathological characteristics of many MAS-affected tissues, particularly pituitary, testicular, and adrenal disease. Other rarer disease related features are emerging. The objective of the investigation was to study the pathological and genetic findings of MAS on a tissue-by-tissue basis in classically and nonclassically affected tissues. This was a comprehensive autopsy and genetic analysis. The study was conducted at a tertiary referral university hospital. An adult male patient with MAS and severe disease burden including gigantism was the subject of the study. Interventions included clinical, hormonal, and radiographic studies and gross and microscopic pathology analyses, conventional PCR, and droplet digital PCR analyses of affected and nonaffected tissues. Pathological findings and the presence of GNAS1 mutations were measured. The patient was diagnosed with MAS syndrome at 6 years of age based on the association of café-au-lait spots and radiological signs of polyostotic fibrous dysplasia. Gigantism developed and hyperprolactinemia, hypogonadotropic hypogonadism, and hyperparathyroidism were diagnosed throughout the adult period. The patient died at the age of 39 years from a pulmonary embolism. A detailed study revealed mosaiscism for the p.R201C GNAS1 mutation distributed across many endocrine and nonendocrine tissues. These genetically implicated tissues included rare or previously undescribed disease associations including primary hyperparathyroidism and hyperplasia of the thymus and endocrine pancreas. This comprehensive pathological study of a single patient highlights the complex clinical profile of MAS and illustrates important advances in understanding the

  19. Gigantism treated by pure endoscopic endonasal approach in a case of McCune-Albright syndrome with sphenoid fibrous dysplasia: a case report.

    PubMed

    Sharifi, Guive; Jalessi, Maryam; Sarvghadi, Farzaneh; Farhadi, Mohammad

    2013-12-01

    McCune-Albright syndrome (MAS) is an uncommon polyostotic manifestation of fibrous dysplasia in association with at least one endocrinopathy that is mostly associated with precocious puberty and hyperpigmented skin macules named café-au-lait spots. We present an atypical manifestation of McCune-Albright syndrome in a 19-year-old man with the uncommon association of polyostotic fibrous dysplasia and gigantism in the absence of café-au-lait spots and precocious puberty. He presented with a height increase to 202 cm in the previous 3 years, which had become more progressive in the few months prior. Physical examination revealed only a mild facial asymmetry; however, a computed tomography (CT) scan discovered vast areas of voluminous bones with ground-glass density and thickening involving the craniofacial bones and skull base. Magnetic resonance imaging (MRI) found a right stalk shift of the pituitary with a 20 mm pituitary adenoma. We describe the diagnostic and endoscopic endonasal transsphenoidal approach for excision of the tumor.

  20. McCune Albright syndrome - association of fibrous dysplasia, café-au-lait skin spots and hyperthyroidism – case report

    PubMed Central

    RAUS, IULIAN; COROIU, ROXANA ELENA

    2016-01-01

    McCune–Albright syndrome is a rare sporadic disease characterized by bone fibrous dysplasia, café-au-lait skin spots and a variable association of hyperfunctional endocrine disorders. Fibrous dysplasia (FD), which can involve the craniofacial, axial, and appendicular skeleton, may range from an isolated, asymptomatic monostotic lesion to a severe disabling polyostotic disease involving the entire skeleton. A twenty-five-year old male patient presented to our clinic with recently developed heart palpitations. He had also been feeling pain in the right femur since he was younger, without any trauma history, leading to difficulties of ambulation and limping occasionally. His physical examination revealed café-au-lait spots with irregular borders and right testicular agenesis. Laboratory findings identified hyperthyroidism with hyperparathyroidism. Radiographs of the pelvis revealed multiple lytic lesions of the right femur and magnetic resonance imaging (MRI) characterized these lesions as specific to fibrous dysplasia of the bone, without any insufficiency fracture at this level. The association of café-au-lait skin spots with bone fibrous dysplasia, and hyperthyroidism in this patient suggested the diagnosis of McCune – Albright syndrome. PMID:27857528

  1. Space Station

    NASA Image and Video Library

    1977-01-01

    The Marshall Space Flight Center (MSFC) and the Johnson Space Center (JSC) were each awarded 16-month contracts in April 1976 for the Space Station Systems Analysis Study (SSSAS). Grumman Aerospace Corporation was MSFC's contractor and McDornell Douglas Aerospace Company was JSC's contractor. The goal of this study was to formulate plans for a permanent operational base and laboratory facility in Earth orbit in addition to developing a space construction base design for implementing the program. An expended Space Shuttle external tank was to be the central core platform of the base, and additional pressurized modules could be added to provide laboratory facilities. This artist's concept depicts a space construction base design for implementing the SSSAS.

  2. Space Station Power System issues

    NASA Technical Reports Server (NTRS)

    Forestieri, A. F.

    1985-01-01

    A number of attractive options are available for the Space Station Power System. These include a photovoltaic system or solar dynamic system for power generation, batteries or fuel cells for energy storage and ac or dc for power management and distribution. These options are being explored during the present preliminary design and definition phase of the Space Station Program. Final selections are presently targeted for January 1986.

  3. Low temperature conversion (LTC)--an alternative method to treat sludge generated in an industrial wastewater treatment station--batch and continuous process comparison.

    PubMed

    Vieira, G E G; Romeiro, G A; Sella, S M; Damasceno, R N; Pereira, R G

    2009-02-01

    In this work low temperature conversion (LTC) process was applied in a dried sludge from a petrochemical industry wastewater treatment station located in Rio de Janeiro, Brazil. The process was performed in two modes: continuous and batch-scale. This process produced a pyrolysis oil (continuous 14%; batch-scale 40% yield); pyrolytic char (continuous 46%; batch-scale 56% yield); gas and water. Pyrolysis oil fraction was analyzed by gas chromatographic mass spectrometry (GCMS) and the main components identified were toluene, ethylbenzene, styrene, isopropyl benzene, alpha-methylstyrene, butanenitrile and 1,3- biphenyl propane. Metals content, sulfur content and calorific value have been determined for the pyrolysis oil fraction. The results showed that the pyrolysis oil obtained could be used for industrial purposes and/or as energetic matrix.

  4. International Space Station (ISS)

    NASA Image and Video Library

    2001-02-01

    The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient, and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This photograph shows the development Water Processor located in two racks in the ECLSS test area at the Marshall Space Flight Center. Actual waste water, simulating Space Station waste, is generated and processed through the hardware to evaluate the performance of technologies in the flight Water Processor design.

  5. Intragenic suppression of a constitutively active allele of Gsα associated with McCune-Albright syndrome.

    PubMed

    Tobar-Rubin, Raquel; Sultan, Dahlia; Janevska, Daniela; Turcic, Kyle; Carroll, Julie; Ooms, Laura; Pals-Rylaarsdam, Robin

    2013-04-01

    McCune-Albright syndrome (MAS) is a human genetic disorder caused by a mutation that constitutively activates the G(s)α subunit by abolishing GTP hydrolysis. MAS patients suffer from a range of endocrinopathies as well as polyostotic fibrous dysplasia of bone. We previously identified an intragenic suppressor of the MAS mutation in a yeast system, which substituted two residues in the GTP-binding site of Gpa1: L318P and D319V to suppress the constitutive activity of an R297H mutation, corresponding to the human F222P, D223V, and R201H mutations respectively. To extend these studies, the human GNAS gene was subjected to site-directed mutagenesis. Constructs expressing the MAS mutation (R201H), the MAS mutation plus the mutations homologous to the yeast suppressors (R201H, F222P/D223V), or the yeast suppressor mutation alone (F222P/D223V) were transfected into HEK293 cells, and basal and receptor-stimulated cAMP levels were measured. Expression of R201H increased the basal cAMP levels and decreased the EC(50) for hormone-stimulated cAMP production. These effects were dependent on the amount of R201H protein expressed. R201H, F222P/D223V abolished the constitutive activity of the MAS mutation and caused responses to hormone that were not different from those measured in cells expressing WT G(s)α. Interestingly, F222P/D223V behaved similar to R201H in causing increases in basal cAMP production, thus demonstrating constitutive activity. Substitution of another acidic (E) or polar (N, T, and G) amino acid at position 223 caused no suppression of R201H activity, while substitution of a second nonpolar amino acid (A) at this position partially suppressed, and the larger polar I residue completely suppressed the effects of R201H.

  6. Outcome of Long-Term Bisphosphonate Therapy in McCune-Albright Syndrome and Polyostotic Fibrous Dysplasia.

    PubMed

    Majoor, Bas Cj; Appelman-Dijkstra, Natasha M; Fiocco, Martha; van de Sande, Michiel Aj; Dijkstra, Pd Sander; Hamdy, Neveen At

    2017-02-01

    McCune-Albright syndrome (MAS) is a rare bone disorder characterized by fibrous dysplasia (FD), endocrinopathies, and café-au-lait patches. FD patients have been shown to respond favorably to treatment with bisphosphonates, but data are scarce in the more severe polyostotic form (PFD), including MAS, and factors determining treatment outcome are not known, particularly in the long-term. We evaluated the biochemical (bone turnover markers [BTMs]) and clinical (pain reduction) outcome of bisphosphonate therapy in 11 patients with MAS and 30 patients with PFD: median duration of treatment 6 years (range, 2 to 25 years). Prognostic factors for treatment outcome were identified in both groups. Patients with MAS were younger at diagnosis (p = 0.001), all had precocious puberty, and four (36%) had additional growth hormone (GH) excess associated with severe craniofacial FD. Extent of skeletal disease was more severe in MAS compared to PFD. MAS patients had higher serum alkaline phosphatase (ALP) concentrations (p = 0.005), higher skeletal burden scores (p < 0.001), and more fractures (p = 0.021). MAS patients had also higher levels of FGF-23 (p = 0.008) and higher prevalence of hypophosphatemia (p = 0.013). Twenty-four of 30 PFD patients (80%) demonstrated a complete clinical and biochemical response within a year of starting treatment (p = 0.015), compared to only four of 11 MAS patients (36%). There were no nonresponders. In the whole group, FGF-23, total ALP, P1NP, and CTX positively correlated with skeletal burden scores (all p ≤ 0.001), which was the only significant risk factor for an incomplete response to bisphosphonate therapy (p < 0.01). Our data suggest a beneficial and safe outcome of long-term bisphosphonate therapy in the majority of patients with PFD, although response to therapy was limited by the higher skeletal disease burden in MAS patients. In the PFD/MAS population studied, the only identified prognostic factor

  7. Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome.

    PubMed

    Akintoye, Sunday O; Chebli, Caroline; Booher, Susan; Feuillan, Penelope; Kushner, Harvey; Leroith, Derek; Cherman, Natasha; Bianco, Paolo; Wientroub, Shlomo; Robey, Pamela Gehron; Collins, Michael T

    2002-11-01

    McCune-Albright syndrome (MAS) is a disorder characterized by the triad of café-au-lait skin pigmentation, polyostotic fibrous dysplasia of bone, and hyperfunctioning endocrinopathies, including GH excess. The molecular etiology of the disease is postzygotic activating mutations of the GNAS1 gene product, G(s)alpha. The term gsp oncogene has been assigned to these mutations due to their association with certain neoplasms. The aim of this study was to estimate the prevalence of GH excess in MAS, characterize the clinical and endocrine manifestations, and describe the response to treatment. Fifty-eight patients with MAS were screened, and 22 with stigmata of acromegaly and/or elevated GH or IGF-I underwent oral glucose tolerance testing. Twelve patients (21%) had GH excess, based on failure to suppress serum GH on oral glucose tolerance test, and underwent a TRH test, serial GH sampling from 2000-0800 h, and magnetic resonance imaging of the sella. We found that vision and hearing deficits were more common in patients with GH excess (4 of 12, 33%) than those without (2 of 56, 4%). Of interest, patients with a history of precocious puberty and GH excess who had reached skeletal maturity achieved normal adult height despite a history of early epiphyseal fusion. All 9 patients tested had an increase in serum GH after TRH, 11 of 12 (92%) had hyperprolactinemia, and all 8 tested had detectable or elevated nighttime GH levels. Pituitary adenoma was detected in 4 of 12 (33%) patients. All patients with elevated IGF-I levels were treated with cabergoline (7 patients), long-acting octreotide (LAO; 8 patients), or a combination of cabergoline and LAO (4 patients). In six of the seven patients (86%) treated with cabergoline, serum IGF-I decreased, but not to the normal range. In the eight patients treated with LAO alone, IGF-I decreased, and, in four, returned to the normal range. The remaining 4 patients were treated with a combination of cabergoline and LAO. For them

  8. A reagentless technology to prevent biofouling on the surfaces of equipment at nuclear and thermal power stations using generators of OH radicals and ozone

    NASA Astrophysics Data System (ADS)

    Izyumov, S. V.; Shchekotov, E. Yu.; Shchekotov, D. E.; Krutskikh, D. A.

    2011-07-01

    We present the results obtained from the development and tests of a reagentless method to prevent biofouling in water cooling systems of equipment using generators of OH radicals and ozone constructed on the basis of impulse ultraviolet xenon lamps producing light with a wavelength of 172 nm.

  9. Aerospace crew station design

    NASA Technical Reports Server (NTRS)

    Carr, Gerald P. (Editor); Montemerlo, Melvin D. (Editor)

    1984-01-01

    Consideration is given to spacecraft cockpits and work stations, commercial aircraft cockpits and crew stations, high performance aircraft cockpits and crew stations, and space stations and habitat crew stations. Particular attention is given to an historical review of NASA manned spacecraft crew stations, ESA spacelab crew stations, the evolution of commercial aircraft flight station design, Boeing 757/767 flight deck, a historical review of Concorde flight deck design, trends in the cockpit design of new European fighters, and state-of-the-art applications for Space Station crew interface design.

  10. Space station contamination considerations

    NASA Technical Reports Server (NTRS)

    Leger, L.; Ehlers, H.; Jacobs, S.

    1986-01-01

    The external induced environment generated by space station activity, or more specifically by gases, particles, and light background is discussed. These contaminant species must be controlled if sensitive systems, such as solar energy collectors or science experiments exposed to the external environment are to function properly. The requirements generally set limits on the level of gas species, matter deposited on surfaces and light background levels over various spectral regions. They also address environment monitoring and contamination controls during manufacturing. Limits on effluent release and system leakages are in turn derived from these requirements.

  11. Space station ventilation study

    NASA Technical Reports Server (NTRS)

    Colombo, G. V.; Allen, G. E.

    1972-01-01

    A ventilation system design and selection method which is applicable to any manned vehicle were developed. The method was used to generate design options for the NASA 33-foot diameter space station, all of which meet the ventilation system design requirements. System characteristics such as weight, volume, and power were normalized to dollar costs for each option. Total system costs for the various options ranged from a worst case $8 million to a group of four which were all approximately $2 million. A system design was then chosen from the $2 million group and is presented in detail. A ventilation system layout was designed for the MSFC space station mockup which provided comfortable, efficient ventilation of the mockup. A conditioned air distribution system design for the 14-foot diameter modular space station, using the same techniques, is also presented. The tradeoff study resulted in the selection of a system which costs $1.9 million, as compared to the alternate configuration which would have cost $2.6 million.

  12. Report to the NRC on guidance for preparing scenarios for emergency preparedness exercises at nuclear generating stations. Draft report for comment

    SciTech Connect

    Martin, G. F.; Hickey, E. E.; Moeller, M. P.; Schultz, D. H.; Bethke, G. W.

    1986-03-01

    A scenario guidance handbook was prepared to assist emergency planners in developing scenarios for emergency preparedness exercises at nuclear power plants. The handbook provides guidance for the development of the objectives of an exercise, the descriptions of scenario events and responses, and the instructions to the participants. Information concerning implementation of the scenario, critiques and findings, and generation and format of scenario data are also included. Finally, examples of manual calculational techniques for producing radiological data are included as an appendix.

  13. Boxberg III-2 x 500 MW units: Refurbishing and environmental protection measures on the 815 T/H steam generator of works II in Boxberg Power Station

    SciTech Connect

    Cossman, R.; Fritz, M.; Bauchmueller, R.

    1995-12-01

    The object of the upgrading measures on the steam generators is: (1) To comply with the requirements of the German antipollution law, which imposes a permissible NO{sub x} content in the flue gas of less than 200 Mg/m{sup 3} STP and a CO content of less than 250 Mg/m{sup 3} STP. (2) To increase the boiler efficiency and availability and the efficiency of the water/steam cycle.

  14. Onyx embolization of an intraosseous pseudoaneurysm of the middle meningeal artery in a patient with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome.

    PubMed

    Settecase, Fabio; Nicholson, Andrew D; Amans, Matthew R; Higashida, Randall T; Halbach, Van V; Cooke, Daniel L; Dowd, Christopher F; Hetts, Steven W

    2016-03-01

    A 13-year-old boy with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome presented with an enlarging "lump" on his right forehead. A head CT scan revealed a polyostotic fibrous dysplasia involving the entire skull. A 3.4-cm right frontal osseous cavity and an overlying right forehead subcutaneous soft-tissue mass were seen, measuring 5.2 cm in diameter and 1.6 cm thick. Ultrasound of the cavity and overlying mass showed swirling of blood and an arterialized waveform. MRI revealed an en plaque meningioma underlying the cavity. An intraosseous pseudoaneurysm fed by 3 distal anterior division branches of the right middle meningeal artery (MMA) with contrast extravasation was found on angiography. Two MMA feeders were embolized with Onyx, with anterograde filling of the intraosseous cavity with Onyx. A small pocket of residual intracavity contrast filling postembolization from a smaller third MMA feeder eventually thrombosed and the forehead lump regressed.

  15. G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.

    PubMed

    Rao, V V; Schnittger, S; Hansmann, I

    1991-05-01

    Guanine nucleotide-binding proteins, also known as G proteins, mediate intracellular responses to a wide variety of extracellular stimuli. A variety of genes that specify the synthesis of the components of guanine nucleotide proteins have been identified. One of these proteins, termed Gs alpha (GNAS1), is the G protein component of the olfactory signal transduction cascade. Mutations in the GNAS1 gene leading to Gs alpha protein deficiency are known to be associated with pseudohypoparathyroidism Ia (Albright hereditary osteodystrophy) and certain pituitary tumors with acromegaly. Studies on the human--mouse somatic cell hybrids provisionally assigned this gene to chromosome 20. We have now confirmed this localization on chromosome 20 and regionally assigned the GNAS1 gene to 20q12-q13.2 by in situ hybridization.

  16. Association of Exposure to Radio-Frequency Electromagnetic Field Radiation (RF-EMFR) Generated by Mobile Phone Base Stations with Glycated Hemoglobin (HbA1c) and Risk of Type 2 Diabetes Mellitus.

    PubMed

    Meo, Sultan Ayoub; Alsubaie, Yazeed; Almubarak, Zaid; Almutawa, Hisham; AlQasem, Yazeed; Hasanato, Rana Muhammed

    2015-11-13

    Installation of mobile phone base stations in residential areas has initiated public debate about possible adverse effects on human health. This study aimed to determine the association of exposure to radio frequency electromagnetic field radiation (RF-EMFR) generated by mobile phone base stations with glycated hemoglobin (HbA1c) and occurrence of type 2 diabetes mellitus. For this study, two different elementary schools (school-1 and school-2) were selected. We recruited 159 students in total; 96 male students from school-1, with age range 12-16 years, and 63 male students with age range 12-17 years from school-2. Mobile phone base stations with towers existed about 200 m away from the school buildings. RF-EMFR was measured inside both schools. In school-1, RF-EMFR was 9.601 nW/cm² at frequency of 925 MHz, and students had been exposed to RF-EMFR for a duration of 6 h daily, five days in a week. In school-2, RF-EMFR was 1.909 nW/cm² at frequency of 925 MHz and students had been exposed for 6 h daily, five days in a week. 5-6 mL blood was collected from all the students and HbA1c was measured by using a Dimension Xpand Plus Integrated Chemistry System, Siemens. The mean HbA1c for the students who were exposed to high RF-EMFR was significantly higher (5.44 ± 0.22) than the mean HbA1c for the students who were exposed to low RF-EMFR (5.32 ± 0.34) (p = 0.007). Moreover, students who were exposed to high RF-EMFR generated by MPBS had a significantly higher risk of type 2 diabetes mellitus (p = 0.016) relative to their counterparts who were exposed to low RF-EMFR. It is concluded that exposure to high RF-EMFR generated by MPBS is associated with elevated levels of HbA1c and risk of type 2 diabetes mellitus.

  17. Association of Exposure to Radio-Frequency Electromagnetic Field Radiation (RF-EMFR) Generated by Mobile Phone Base Stations with Glycated Hemoglobin (HbA1c) and Risk of Type 2 Diabetes Mellitus

    PubMed Central

    Meo, Sultan Ayoub; Alsubaie, Yazeed; Almubarak, Zaid; Almutawa, Hisham; AlQasem, Yazeed; Muhammed Hasanato, Rana

    2015-01-01

    Installation of mobile phone base stations in residential areas has initiated public debate about possible adverse effects on human health. This study aimed to determine the association of exposure to radio frequency electromagnetic field radiation (RF-EMFR) generated by mobile phone base stations with glycated hemoglobin (HbA1c) and occurrence of type 2 diabetes mellitus. For this study, two different elementary schools (school-1 and school-2) were selected. We recruited 159 students in total; 96 male students from school-1, with age range 12–16 years, and 63 male students with age range 12–17 years from school-2. Mobile phone base stations with towers existed about 200 m away from the school buildings. RF-EMFR was measured inside both schools. In school-1, RF-EMFR was 9.601 nW/cm2 at frequency of 925 MHz, and students had been exposed to RF-EMFR for a duration of 6 h daily, five days in a week. In school-2, RF-EMFR was 1.909 nW/cm2 at frequency of 925 MHz and students had been exposed for 6 h daily, five days in a week. 5–6 mL blood was collected from all the students and HbA1c was measured by using a Dimension Xpand Plus Integrated Chemistry System, Siemens. The mean HbA1c for the students who were exposed to high RF-EMFR was significantly higher (5.44 ± 0.22) than the mean HbA1c for the students who were exposed to low RF-EMFR (5.32 ± 0.34) (p = 0.007). Moreover, students who were exposed to high RF-EMFR generated by MPBS had a significantly higher risk of type 2 diabetes mellitus (p = 0.016) relative to their counterparts who were exposed to low RF-EMFR. It is concluded that exposure to high RF-EMFR generated by MPBS is associated with elevated levels of HbA1c and risk of type 2 diabetes mellitus. PMID:26580639

  18. International Space Station Overview

    NASA Technical Reports Server (NTRS)

    Bates, William V., Jr.

    1999-01-01

    The overview of the International Space Station (ISS) is comprised of the program vision and mission; Space Station uses; definition of program phases; as well as descriptions and status of several scheduled International Space Station Overview assembly flights.

  19. Intelligent Virtual Station (IVS)

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The Intelligent Virtual Station (IVS) is enabling the integration of design, training, and operations capabilities into an intelligent virtual station for the International Space Station (ISS). A viewgraph of the IVS Remote Server is presented.

  20. Space Station Freedom

    NASA Technical Reports Server (NTRS)

    1991-01-01

    In 1982, the Space Station Task Force was formed, signaling the initiation of the Space Station Freedom Program, and eventually resulting in the Marshall Space Flight Center's responsibilities for Space Station Work Package 1.

  1. Intelligent Virtual Station (IVS)

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The Intelligent Virtual Station (IVS) is enabling the integration of design, training, and operations capabilities into an intelligent virtual station for the International Space Station (ISS). A viewgraph of the IVS Remote Server is presented.

  2. A disruptive mutation in exon 3 of the GNAS gene with albright hereditary osteodystrophy, normocalcemic pseudohypoparathyroidism, and selective long transcript variant Gsalpha-L deficiency.

    PubMed

    Thiele, Susanne; Werner, Ralf; Ahrens, Wiebke; Hoppe, Ute; Marschke, Christine; Staedt, Pia; Hiort, Olaf

    2007-05-01

    The GNAS gene encodes the alpha-subunit of stimulatory G proteins, which play a crucial role in intracellular signal transduction of peptide and neurotransmitter receptors. In addition to transcript variants that differ in their first exon due to different promoters, there are two long (Gsalpha-L) and two short (Gsalpha-S) splice variants, created by alternative splicing. Heterozygous inactivating maternally inherited mutations of GNAS lead to a phenotype in which Albright hereditary osteodystrophy is associated with pseudohypoparathyroidism type Ia. The GNAS gene of a 10-yr-old girl with brachymetacarpia, mental retardation, normocalcemic pseudohypoparathyroidism, and hypothyroidism was investigated. We found a heterozygous insertion of an adenosine in exon 3 altering codon 85 and leading to a frame shift inducing a stop codon in exon 4. Molecular studies of cDNA from blood RNA demonstrated normal, biallelic expression of Gsalpha-S transcripts, whereas expression of Gsalpha-L transcripts from the maternal allele was reduced. Immunoblot analysis revealed a reduced Gsalpha-L protein level to about 50%, whereas the protein level of Gsalpha-S was unaltered. Furthermore, the Gsalpha protein activity in erythrocyte membranes was diminished to about 75% of normal. Both the reduced activity and the mutation were also found in the mother and the affected younger brother. This report demonstrates the first evidence for a pathogenic mutation in exon 3 of the GNAS gene. The mutation is associated with a phenotype of Albright hereditary osteodystrophy and pseudohypoparathyroidism type Ia due to selective deficiency of Gsalpha-L and a partial reduction of Gsalpha activity.

  3. RF Environment Test on a Proposed Site for the Sensor Station of the Next Generation Satellite Navigation System, GALILEO: I. The Result of the Test on the Vicinity of KVN Tamla Site in the Year of 2006 by KASI

    NASA Astrophysics Data System (ADS)

    Jo, Jung Hyun; Je, Do-Hyeung; Cho, Sungki; Choi, Byung Kyu; Baek, Jeongho; Lee, Daekyu; Chung, Hyunsoo; Lim, Hyung-Chul; Cho, Jung-Ho; Lee, Woo-Kyoung; Jung, Sung-Wook; Park, Jong-Uk; Choe, Nammi

    2008-03-01

    As the next generation of global satellite navigation system, the Galileo project is about to witness an initial orbit validation stage as the successful test of navigation message transmission from Giove-A in 2007. The Space Geodesy division and the Radio Astronomy division of the Korea Astronomy & Space Science Institute had collaborated on the field survey for the Galileo Sensor Station (GSS) RF environment of the proposed site near Jeju Tamla University from August 3rd to August 5th, 2006. The power spectrums were measured in full-band (800 ˜ 2000 MHz) and in-band (E5, E6 and L1 band) in frequency domain for 24 hours respectively. Finally, we performed a time domain analysis to characterize strong in-band interference source based on the result of the previous step.

  4. Submerged AUV Charging Station

    NASA Technical Reports Server (NTRS)

    Jones, Jack A.; Chao, Yi; Curtin, Thomas

    2014-01-01

    Autonomous Underwater Vehicles (AUVs) are becoming increasingly important for military surveillance and mine detection. Most AUVs are battery powered and have limited lifetimes of a few days to a few weeks. This greatly limits the distance that AUVs can travel underwater. Using a series of submerged AUV charging stations, AUVs could travel a limited distance to the next charging station, recharge its batteries, and continue to the next charging station, thus traveling great distances in a relatively short time, similar to the Old West “Pony Express.” One solution is to use temperature differences at various depths in the ocean to produce electricity, which is then stored in a submerged battery. It is preferred to have the upper buoy submerged a reasonable distance below the surface, so as not to be seen from above and not to be inadvertently destroyed by storms or ocean going vessels. In a previous invention, a phase change material (PCM) is melted (expanded) at warm temperatures, for example, 15 °C, and frozen (contracted) at cooler temperatures, for example, 8 °C. Tubes containing the PCM, which could be paraffin such as pentadecane, would be inserted into a container filled with hydraulic oil. When the PCM is melted (expanded), it pushes the oil out into a container that is pressurized to about 3,000 psi (approx equals 20.7 MPa). When a valve is opened, the high-pressure oil passes through a hydraulic motor, which turns a generator and charges a battery. The low-pressure oil is finally reabsorbed into the PCM canister when the PCM tubes are frozen (contracted). Some of the electricity produced could be used to control an external bladder or a motor to the tether line, such that depth cycling is continued for a very long period of time. Alternatively, after the electricity is generated by the hydraulic motor, the exiting low-pressure oil from the hydraulic motor could be vented directly to an external bladder on the AUV, such that filling of the bladder

  5. Space station user's handbook

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A user's handbook for the modular space station concept is presented. The document is designed to acquaint science personnel with the overall modular space station program, the general nature and capabilities of the station itself, some of the scientific opportunities presented by the station, the general policy governing its operation, and the relationship between the program and participants from the scientific community.

  6. 36. SITE BUILDING 004 ELECTRIC POWER STATION CLOSE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. SITE BUILDING 004 - ELECTRIC POWER STATION - CLOSE UP VIEW OF 1200 HORSEPOWER STANDBY POWER DIESEL ENGINE/GENERATOR SETS. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  7. 38. SITE BUILDING 004 ELECTRIC POWER STATION AT INTERIOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. SITE BUILDING 004 - ELECTRIC POWER STATION AT INTERIOR - OBLIQUE VIEW AT FLOOR LEVEL SHOWING DIESEL ENGINE/GENERATOR SET NUMBER 5. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  8. 37. SITE BUILDING 004 ELECTRIC POWER STATION ELEVATED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. SITE BUILDING 004 - ELECTRIC POWER STATION - ELEVATED VIEW OF FIVE (5) 1200 HORSEPOWER STANDBY - POWER DIESEL ENGINE/GENERATOR SETS. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  9. 21. EASTWEST SECTION THROUGH MIDPOINT OF STATION (Drawing 4921841040) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. EAST-WEST SECTION THROUGH MIDPOINT OF STATION (Drawing 49218-41040) - Cabot Station Electric Generating Plant, Gantry Crane, Montague City Road, Turners Falls vicinity, Montague, Franklin County, MA

  10. Space Station Spartan study

    NASA Technical Reports Server (NTRS)

    Lane, J. H.; Schulman, J. R.; Neupert, W. M.

    1985-01-01

    The required extension, enhancement, and upgrading of the present Spartan concept are described to conduct operations from the space station using the station's unique facilities and operational features. The space station Spartan (3S), the free flyer will be deployed from and returned to the space station and will conduct scientific missions of much longer duration than possible with the current Spartan. The potential benefits of a space station Spartan are enumerated. The objectives of the study are: (1) to develop a credible concept for a space station Spartan; and (2) to determine the associated requirements and interfaces with the space station to help ensure that the 3S can be properly accommodated.

  11. 12. VIEW OF OPERATING ROOMRCA COMMUNICATION REC STATION (THIS ROOM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF OPERATING ROOM-RCA COMMUNICATION REC STATION (THIS ROOM WAS ORIGINALLY A MOTOR GENERATOR FACILITY AND SUPPLIED DC POWER TO AN EARLIER GENERATION OF POINT-TO-POINT RECEIVERS ON SECOND FLOOR). VIEW SHOWS TRANSMITTER CONTROL STATION AND AUDIO CONTROL STATION (LEFT, WATKINS-JOHNSON WJ-8718-23. HP RECEIVERS AND KENWOOD R-5000 COMMUNICATIONS RECEIVERS (220 DEGREES). - Marconi Radio Sites, Receiving, Point Reyes Station, Marin County, CA

  12. OSSA Space Station waste inventory

    NASA Technical Reports Server (NTRS)

    Rasmussen, Daryl N.; Johnson, Catherine C.; Bosley, John J.; Curran, George L.; Mains, Richard

    1987-01-01

    NASA's Office of Space Science and Applications has compiled an inventory of the types and quantities of the wastes that will be generated by the Space Station's initial operational phase in 35 possible mission scenarios. The objective of this study was the definition of waste management requirements for both the Space Station and the Space Shuttles servicing it. All missions, when combined, will produce about 5350 kg of gaseous, liquid and solid wastes every 90 days. A characterization has been made of the wastes in terms of toxicity, corrosiveness, and biological activity.

  13. OSSA Space Station waste inventory

    NASA Technical Reports Server (NTRS)

    Rasmussen, Daryl N.; Johnson, Catherine C.; Bosley, John J.; Curran, George L.; Mains, Richard

    1987-01-01

    NASA's Office of Space Science and Applications has compiled an inventory of the types and quantities of the wastes that will be generated by the Space Station's initial operational phase in 35 possible mission scenarios. The objective of this study was the definition of waste management requirements for both the Space Station and the Space Shuttles servicing it. All missions, when combined, will produce about 5350 kg of gaseous, liquid and solid wastes every 90 days. A characterization has been made of the wastes in terms of toxicity, corrosiveness, and biological activity.

  14. International Space Station (ISS)

    NASA Image and Video Library

    2006-12-09

    Against a black night sky, the Space Shuttle Discovery and its seven-member crew head toward Earth-orbit and a scheduled linkup with the International Space Station (ISS). Liftoff from the Kennedy Space Center's launch pad 39B occurred at 8:47 p.m. (EST) on Dec. 9, 2006 in what was the first evening shuttle launch since 2002. The primary mission objective was to deliver and install the P5 truss element. The P5 installation was conducted during the first of three space walks, and involved use of both the shuttle and station’s robotic arms. The remainder of the mission included a major reconfiguration and activation of the ISS electrical and thermal control systems, as well as delivery of Zvezda Service Module debris panels, which will increase ISS protection from potential impacts of micro-meteorites and orbital debris. Two major payloads developed at the Marshall Space Flight Center (MSFC) were also delivered to the Station. The Lab-On-A Chip Application Development Portable Test System (LOCAD-PTS) and the Water Delivery System, a vital component of the Station’s Oxygen Generation System.

  15. Draper Station Analysis Tool

    NASA Technical Reports Server (NTRS)

    Bedrossian, Nazareth; Jang, Jiann-Woei; McCants, Edward; Omohundro, Zachary; Ring, Tom; Templeton, Jeremy; Zoss, Jeremy; Wallace, Jonathan; Ziegler, Philip

    2011-01-01

    Draper Station Analysis Tool (DSAT) is a computer program, built on commercially available software, for simulating and analyzing complex dynamic systems. Heretofore used in designing and verifying guidance, navigation, and control systems of the International Space Station, DSAT has a modular architecture that lends itself to modification for application to spacecraft or terrestrial systems. DSAT consists of user-interface, data-structures, simulation-generation, analysis, plotting, documentation, and help components. DSAT automates the construction of simulations and the process of analysis. DSAT provides a graphical user interface (GUI), plus a Web-enabled interface, similar to the GUI, that enables a remotely located user to gain access to the full capabilities of DSAT via the Internet and Webbrowser software. Data structures are used to define the GUI, the Web-enabled interface, simulations, and analyses. Three data structures define the type of analysis to be performed: closed-loop simulation, frequency response, and/or stability margins. DSAT can be executed on almost any workstation, desktop, or laptop computer. DSAT provides better than an order of magnitude improvement in cost, schedule, and risk assessment for simulation based design and verification of complex dynamic systems.

  16. International Space Station (ISS)

    NASA Image and Video Library

    2000-01-01

    This diagram shows the flow of water recovery and management in the International Space Station (ISS). The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center is responsible for the regenerative ECLSS hardware, as well as providing technical support for the rest of the system. The regenerative ECLSS, whose main components are the Water Recovery System (WRS), and the Oxygen Generation System (OGS), reclaims and recycles water oxygen. The ECLSS maintains a pressurized habitation environment, provides water recovery and storage, maintains and provides fire detection/ suppression, and provides breathable air and a comfortable atmosphere in which to live and work within the ISS. The ECLSS hardware will be located in the Node 3 module of the ISS.

  17. International Space Station (ISS)

    NASA Image and Video Library

    2000-01-01

    This diagram shows the flow of recyclable resources in the International Space Station (ISS). The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center is responsible for the regenerative ECLSS hardware, as well as providing technical support for the rest of the system. The regenerative ECLSS, whose main components are the Water Recovery System (WRS), and the Oxygen Generation System (OGS), reclaims and recycles water and oxygen. The ECLSS maintains a pressurized habitation environment, provides water recovery and storage, maintains and provides fire detection / suppression, and provides breathable air and a comfortable atmosphere in which to live and work within the ISS. The ECLSS hardware will be located in the Node 3 module of the ISS.

  18. Local control stations

    SciTech Connect

    Brown, W.S.; Higgins, J.C.; Wachtel, J.A.

    1993-05-01

    This paper describes research concerning the effects of human engineering design at local control stations (i.e., operator interfaces located outside the control room) on human performance and plant safety. The research considered both multifunction panels (e.g. remote shutdown panels) as well as single-function interfaces (e.g., valves, breakers, gauges, etc.). Changes in performance shaping factors associated with variations in human engineering at LCSs were estimated based on expert opinion. By means of a scaling procedure, these estimates were used to modify the human error probabilities in a PRA model, which was then employed to generate estimates of plant risk and scoping-level value/impact ratios for various human engineering upgrades. Recent documentation of human engineering deficiencies at single-function LCSs was also reviewed, and an assessment of the current status of LCSs with respect to human engineering was conducted.

  19. Space Station Technology Summary

    NASA Technical Reports Server (NTRS)

    Iacabucci, R.; Evans, S.; Briley, G.; Delventhal, R. A.; Braunscheidel, E.

    1989-01-01

    The completion of the Space Station Propulsion Advanced Technology Programs established an in-depth data base for the baseline gaseous oxygen/gaseous hydrogen thruster, the waste gas resistojet, and the associated system operations. These efforts included testing of a full end-to-end system at National Aeronautics and Space Administration (NASA)-Marshall Space Flight Center (MSFC) in which oxygen and hydrogen were generated from water by electrolysis at 6.89 MPa (1,000 psia), stored and fired through the prototype thruster. Recent end-to-end system tests which generate the oxygen/hydrogen propellants by electrolysis of water at 20.67 MPa (3,000 psia) were completed on the Integrated Propulsion Test Article (IPTA) at NASA-Johnson Space Center (JSC). Resistojet testing has included 10,000 hours of life testing, plume characterization, and electromagnetic interference (EMI) testing. Extensive 25-lbf thruster testing was performed defining operating performance characteristics across the required mixture ratio and thrust level ranges. Life testing has accumulated 27 hours of operation on the prototype thruster. A total of seven injectors and five thrust chambers were fabricated to the same basic design. Five injectors and three thrust chambers designed to incorporate improved life, performance, and producibility characteristics are ready for testing. Five resistojets were fabricated and tested, with modifications made to improve producibility. The lessons learned in the area of producibility for both the O2/H2 thrusters and for the resistojet have resolved critical fabrication issues. The test results indicate that all major technology issues for long life and reliability for space station application were resolved.

  20. 47 CFR 73.877 - Station logs for LPFM stations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Station logs for LPFM stations. 73.877 Section... BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.877 Station logs for LPFM stations. The licensee of each LPFM station must maintain a station log. Each log entry must include the time and date...

  1. 47 CFR 73.877 - Station logs for LPFM stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Station logs for LPFM stations. 73.877 Section... BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.877 Station logs for LPFM stations. The licensee of each LPFM station must maintain a station log. Each log entry must include the time and date...

  2. 47 CFR 73.877 - Station logs for LPFM stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Station logs for LPFM stations. 73.877 Section... BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.877 Station logs for LPFM stations. The licensee of each LPFM station must maintain a station log. Each log entry must include the time and date...

  3. 47 CFR 73.877 - Station logs for LPFM stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Station logs for LPFM stations. 73.877 Section... BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.877 Station logs for LPFM stations. The licensee of each LPFM station must maintain a station log. Each log entry must include the time and date...

  4. 47 CFR 73.877 - Station logs for LPFM stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Station logs for LPFM stations. 73.877 Section... BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.877 Station logs for LPFM stations. The licensee of each LPFM station must maintain a station log. Each log entry must include the time and date...

  5. Station Tour: Russian Segment

    NASA Image and Video Library

    Expedition 33 Commander Suni Williams concludes her tour of the International Space Station with a visit to the Russian segment, which includes Zarya, the first segment of the station launched in 1...

  6. IPALCO's Proposed Patriot, Indiana Generating Station

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  7. BACT Baseline for Louisa Generating Station

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  8. Radio spectrum surveillance station

    NASA Technical Reports Server (NTRS)

    Hersey, D. R.

    1979-01-01

    The paper presents a general and functional description of a low-cost surveillance station designed as the first phase of NASA's program to develop a radio spectrum surveillance capability for deep space stations for identifying radio frequency interference sources. The station described has identified several particular interferences and is yielding spectral signature data which, after cataloging, will serve as a library for rapid identification of frequently observed interference. Findings from the use of the station are discussed.

  9. International Space Station (ISS)

    NASA Image and Video Library

    1997-07-20

    Photograph shows the International Space Station Laboratory Module under fabrication at Marshall Space Flight Center (MSFC), Building 4708 West High Bay. Although management of the U.S. elements for the Station were consolidated in 1994, module and node development continued at MSFC by Boeing Company, the prime contractor for the Space Station.

  10. Space Station Live: Station Communications Upgrade

    NASA Image and Video Library

    NASA Public Affairs Officer Nicole Cloutier-Lemasters recently spoke with Penny Roberts, one of the leads for the International Space Station Avionics and Software group, about the upgrade of the K...

  11. International Space Station (ISS)

    NASA Image and Video Library

    2000-09-01

    The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center (MSFC) in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This is a close-up view of ECLSS Oxygen Generation System (OGS) rack. The ECLSS Group at the MSFC oversees the development of the OGS, which produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen lost due to experiment use, airlock depressurization, module leakage, and carbon dioxide venting. The OGS consists primarily of the Oxygen Generator Assembly (OGA), provided by the prime contractor, the Hamilton Sundstrand Space Systems, International (HSSSI) in Windsor Locks, Cornecticut and a Power Supply Module (PSM), supplied by the MSFC. The OGA is comprised of a cell stack that electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the Water Recovery System and the separators that remove the gases from water after electrolysis. The PSM provides the high power to the OGA needed to electrolyze the water.

  12. Definition status of the U.S. Space Station system

    NASA Technical Reports Server (NTRS)

    Craig, M. K.

    1986-01-01

    The configuration, design, and capabilities of the Space Station are briefly reviewed. In particular, attention is given to the truss structure, photovoltaic and solar dynamic power generation systems, pressurized habitation and laboratory modules, and provisions for extravehicular activity. The discussion covers the Space Station assembly sequence, and the main elements of the power, communication, environmental, and life support systems of the Space Station.

  13. 49. Photocopy of scale drawing (from Station 'L' office files, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    49. Photocopy of scale drawing (from Station 'L' office files, Portland, Oregon) Portland General Electric in house drawings, 1930 FLOW DIAGRAM OF THE STEAM GENERATION PROCESS AT STATION 'L' - Portland General Electric Company, Station "L", 1841 Southeast Water Street, Portland, Multnomah County, OR

  14. Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome.

    PubMed

    Xu, Jia; Li, Xi; Lv, Chang-Sheng; Chen, Ying; Wang, Meng; Liu, Jian-Feng; Gui, Lai

    2014-09-01

    McCune-Albright syndrome (MAS) is a rare, post-zygotic (non-germline) disorder, characterized by hypersecretory endocrinopathies, fibrous dysplasia of the bone and café-au-lait macules. The most common endocrine dysfunction is gonadal hyperfunction; thus, hypersecretion of growth hormones (GHs) as a manifestation of endocrine hyperfunction in MAS is rarely reported. MAS affects both genders, although the majority of cases have been reported in young females. Atypical presentations of MAS, with only one or two of the classic symptoms, have been previously described, but remain particularly challenging due to the lack of a diagnostic phenotype. In patients with atypical MAS, analysis of mutations in the gene of the α-subunit of the stimulatory G-protein is limited; thus, diagnosis is based on clinical judgment. In the present study, a male with polyostotic fibrous dysplasia and GH-secreting pituitary adenomas, diagnosed with atypical MAS, was reported. The pituitary adenoma was effectively treated with radiotherapy and the patient underwent surgery for the polyostotic fibrous dysplasia, with marked improvements observed in appearance.

  15. Unilateral adrenalectomy can be an alternative therapy for infantile onset Cushing' s syndrome caused by ACTH-independent macronodular adrenal hyperplasia with McCune-Albright syndrome.

    PubMed

    Hamajima, Takashi; Maruwaka, Kaori; Homma, Keiko; Matsuo, Kumihiro; Fujieda, Kenji; Hasegawa, Tomonobu

    2010-01-01

    We report herein the case of a 1-year-old boy with McCune-Albright syndrome (MAS) who presented with infantile-onset Cushing' s syndrome caused by ACTH independent macronodular adrenal hyperplasia (AIMAH). Abdominal CT, MRI, and adrenal scintigraphy with (131)I-adosterol identified bilateral adrenal involvement with the left adrenal gland being larger and functionally more active. Unilateral adrenalectomy of the left gland was performed and ameliorated many clinical symptoms, such as Cushingoid appearance and height restriction, and it also normalized many endocrinological data, such as diurnal rhythms of ACTH and cortisol, ACTH and cortisol responses to CRH, and urinary 24 hr free cortisol. Glucocorticoid was replaced for the first 1 year and 6 months after the operation. One adrenal crisis episode occurred at 3 weeks after the operation, but none have occurred since. These results suggest that unilateral adrenalectomy of the larger gland can be an alternative therapy for infantile onset Cushing' s syndrome caused by AIMAH with MAS, when asymmetric involvement is evident and the smaller gland is not markedly enlarged.

  16. Hypothyroidism in McCune-Albright Syndrome and Role of Bone Scan in Management of Fibrous Dysplasia: An Unusual Case Scenario with Review of Literature.

    PubMed

    Kumar, Narvesh; Kheruka, Subhash Chand; Singh, Rani Kunti R; Ravina, Mudalsha; Dutta, Deepanksha; Gambhir, Sanjay

    2017-01-01

    The McCune-Albright syndrome (MAS) is a triad of café-au-lait skin pigmentation, precocious puberty (PP), and polyostotic fibrous dysplasia of bone (FD). In general, FD seems to be the most common component of MAS but very rarely precocious puberty can be found in association with café-au-lait skin pigmentation in the absence of FD (about 1% of the cases). Therefore, a more clinically relevant definition of MAS is fibrous dysplasia of bone (FD) and at least one of the typical hyperfunctioning endocrinopathy and/or café-au-lait spots, with almost any combination possible. Bone scan can be the modality of choice to look for bone disease burden of fibrous dysplasia in most patients of MAS and may change the management accordingly. Most of the cases of MAS reported worldwide are associated with hyperthyroidism, up to best of our knowledge on the basis of literature search in pubmed and Google; no case was reported with hypothyroidism. Herein, we report a 12-year-old girl diagnosed with MAS and associated hypothyroidism. We have also reviewed the MAS related literature.

  17. Hypothyroidism in McCune–Albright Syndrome and Role of Bone Scan in Management of Fibrous Dysplasia: An Unusual Case Scenario with Review of Literature

    PubMed Central

    Kumar, Narvesh; Kheruka, Subhash Chand; Singh, Rani Kunti R.; Ravina, Mudalsha; Dutta, Deepanksha; Gambhir, Sanjay

    2017-01-01

    The McCune–Albright syndrome (MAS) is a triad of café-au-lait skin pigmentation, precocious puberty (PP), and polyostotic fibrous dysplasia of bone (FD). In general, FD seems to be the most common component of MAS but very rarely precocious puberty can be found in association with café-au-lait skin pigmentation in the absence of FD (about 1% of the cases). Therefore, a more clinically relevant definition of MAS is fibrous dysplasia of bone (FD) and at least one of the typical hyperfunctioning endocrinopathy and/or café-au-lait spots, with almost any combination possible. Bone scan can be the modality of choice to look for bone disease burden of fibrous dysplasia in most patients of MAS and may change the management accordingly. Most of the cases of MAS reported worldwide are associated with hyperthyroidism, up to best of our knowledge on the basis of literature search in pubmed and Google; no case was reported with hypothyroidism. Herein, we report a 12-year-old girl diagnosed with MAS and associated hypothyroidism. We have also reviewed the MAS related literature. PMID:28242980

  18. Glomerular-specific imprinting of the mouse Gs{alpha} gene: How does this relate to hormone resistance in Albright hereditary osteodystrophy?

    SciTech Connect

    Williamson, C.M.; Dutton, E.R.; Seymour, A.

    1996-09-01

    The gene for alpha-stimulating guanine-nucleotide binding polypeptide, Gnas, has been considered as a candidate for the imprinting effects ascribed to distal mouse Chromosome (Chr) 2. Its human homologue (GNAS1) appears, from clinical and biochemical studies of patients with Albright hereditary ostodystrophy, to be paternally imprinted. GNAS1 maps to 20q13, a region that shows linkage conservation with distal mouse Chr 2. We have mapped Gnas within the imprinting region on distal Chr 2 by linkage analysis. To establish if Gnas is imprinted, we have looked for expression differences in tissues taken from mice carrying maternal duplication/paternal deficiency for distal Chr 2 (MatDp2) and its reciprocal (PatDp2). RNA in situ hybridization revealed high levels of Gnas mRNA in glomeruli of PatDp2 embryos at late gestation and lower levels in glomeruli of MatDp2 embryos. These results strongly suggest that Gnas is maternally imprinted and suggest that the mouse gene may be imprinted in a manner opposite the predicted in human. 42 refs., 4 figs.

  19. Odontoiatric perspectives and osteonecrosis of the jaw as a possible adverse effect of bisphosphonates therapy in fibrous dysplasia and McCune-Albright syndrome.

    PubMed

    Tessaris, Daniele; Matarazzo, Patrizia; Lala, Roberto; Defabianis, Patrizia

    2016-03-01

    McCune-Albright syndrome (MAS) is characterized by the triad of polyostotic bone fibrous dysplasia (PFD), endocrine disorders, and café-au-lait skin pigmentation. Ninety percent of MAS patients have fibrous dysplasia (FD) craniofacial lesions. Osteonecrosis of the jaw (ONJ) has been described as an adverse side effect of bisphosphonate therapy. The aim of the study was to investigate evidence of clinical and/or radiological signs of ONJ in FD/MAS pediatric patients due to bisphosphonate therapy and describe odontoiatric tools in this population. Thirteen FD/MAS patients were enrolled. All patients during pediatric age have been treated with pamidronate infusions. They underwent complete oral clinical examination. Ortopantomography and/or CT were evaluated in all cases. No patient developed ONJ. None of them showed radiological signs different from jaw FD. In spite of the low number of patients enrolled, results confirm that, in this population, ONJ can be ruled out as a chronic adverse side effect of bisphosphonate therapy.

  20. A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune–Albright syndrome

    PubMed Central

    Karadag, Abdullah; Riminucci, Mara; Bianco, Paolo; Cherman, Natasha; Kuznetsov, Sergei A.; Nguyen, Nga; Collins, Michael T.; Robey, Pamela G.; Fisher, Larry W.

    2004-01-01

    Somatic mutations are present in various proportions in numerous developmental pathologies. Somatic activating missense mutations of the GNAS gene encoding the Gsα protein have previously been shown to be the cause of fibrous dysplasia of bone (FD)/McCune-Albright syndrome (MAS). Because in MAS patients, tissues as diverse as melanocytes, gonads and bone are affected, it is generally accepted that the GNAS mutation in this disease must have occurred early in development. Interestingly, it has been shown that the development of an active FD lesion may require both normal and mutant cells. Studies of the somatic mosaic states of FD/MAS and many other somatic diseases need an accurate method to determine the ratio of mutant to normal cells in a given tissue. A new method for quantification of the mutant:normal ratio of cells using a PNA hybridization probe-based FRET technique was developed. This novel technique, with a linear sensitivity of 2.5% mutant alleles, was used to detect the percentage mutant cells in a number of tissue and cell culture samples derived from FD/MAS lesions and could easily be adapted for the quantification of mutations in a large spectrum of diseases including cancer. PMID:15096559

  1. Deletion mutations of the Bs-alpha gene in patients with Albright hereditary osteodystrophy: Possible mutation hot-spot in exon 7

    SciTech Connect

    Weinstein, L.S.; Hainline, B.E.; Schuster, V.

    1994-09-01

    Albright hereditary osteodystrophy (AHO) is an autosomal dominant disease characterized by short stature, centripetal obesity, subcutaneous ossifications and focal brachydactyly. Patients with this disorder may have these features alone (pseudopseudohypoparathyroidism) or these features in association with resistance to multiple hormones which raise intracellular cAMP (pseudohypoparathyroidism, PHP). In most kindreds, affected members have decreased function of the G protein Gs and decreased levels of the Gs{alpha}-subunit. Heterozygous inactivating mutations of the Gs{alpha} gene have been previously identified in AHO. Exons 2-13 of the Gs{alpha} gene and their splice junctions were PCR-amplified and the products analyzed by temperature gradient gel electrophoresis (TGGE) and direct sequencing. Using this approach, a new heterozygous 2 bp deletion in exon 4 creating a premature stop codon was identified in 5 affected members of a previously reported family. The mutation was not present in an unaffected family member. We also have identified a previously reported 4 bp deletion in the coding region of exon 7 in 2 further unrelated sporadic cases of PHP. In one case, the mutation was absent in her siblings and in both parents, confirming that this is a de novo mutation in this patient. This specific 4 bp deletion has now been reported in 4 PHP patients, at least 3 of whom are unrelated. These results suggest that this region of the Gs{alpha} gene may be a hot-spot for deletions.

  2. Three-Quarters Adrenalectomy for Infantile-Onset Cushing Syndrome due to Bilateral Adrenal Hyperplasia in McCune-Albright Syndrome.

    PubMed

    Itonaga, Tomoyo; Goto, Hironori; Toujigamori, Manabu; Ohno, Yasuharu; Korematsu, Seigo; Izumi, Tatsuro; Narumi, Satoshi; Hasegawa, Tomonobu; Ihara, Kenji

    2017-05-19

    Bilateral adrenalectomy is performed in cases with infantile-onset Cushing syndrome due to bilateral adrenal hyperplasia in McCune-Albright syndrome (MAS) because severe Cushing syndrome with heart failure and liver dysfunction can have a lethal outcome. This procedure can completely ameliorate hypercortisolism, although lifetime steroid replacement therapy and steps to prevent adrenal crisis are necessary. Recently, the efficacy of unilateral adrenalectomy has been reported in adult cases of bilateral macronodular adrenal hyperplasia, but there is no consensus regarding the appropriate surgical treatment for bilateral adrenal hyperplasia in MAS. A 6-month-old girl presented with café-au-lait spots, short stature, central obesity, a moon face, and hypertension. Endocrinological tests and imaging studies led to the diagnosis of ACTH-independent Cushing syndrome due to bilateral adrenal hyperplasia induced by MAS. "Three-quarters adrenalectomy", namely right-sided total adrenalectomy and left-sided half adrenalectomy, was carried out. An activating mutation of the GNAS1 gene (p.Arg201Cys) was identified in the adrenal tissues. Since the operation, our patient has been in a state of clinical remission for more than 2 years. Our original surgical intervention, three-quarters adrenalectomy, may be a new treatment option for Cushing syndrome associated with MAS. © 2017 S. Karger AG, Basel.

  3. A new heterozygous mutation (L338N) in the human Gsalpha (GNAS1) gene as a cause for congenital hypothyroidism in Albright's hereditary osteodystrophy.

    PubMed

    Pohlenz, Joachim; Ahrens, Wiebke; Hiort, Olaf

    2003-04-01

    To identify the molecular defect by which psychomotor retardation is caused in two brothers with congenital hypothyroidism who received adequate treatment with l-thyroxine. A six-year-old boy presented with psychomotor retardation and congenital primary hypothyroidism (CH). The patient had a normal blood thyrotrophin (TSH) level on neonatal screening, but low total serum thyroxine and triiodothyronine concentrations prompting thyroid hormone substitution shortly after birth. Nevertheless, psychomotor development was retarded and the patient underwent further investigation. Typical features of Albright's hereditary osteodystrophy (AHO) such as round face, obesity, and shortened 1st, 4th and 5th metacarpals were found. Further investigation confirmed AHO with pseudohypoparathyroidism (PHP) type Ia. The boy had a mild resistance to parathyroid hormone and a reduced adenylyl cyclase stimulating protein (Gsalpha) activity in erythrocytes. DNA analysis detected a new heterozygous mutation (L338N) in the Gsalpha protein (GNAS1) gene. This mutation was also present in the patient's brother who had similar features and was also treated with thyroid hormone because of CH, and in the phenotypically normal-looking mother who had a normal calcium metabolism but a reduced Gsalpha protein activity in erythrocytes suggestive of pseudopseudohypoparathyroidism. In patients with CH, in whom the neurological outcome is poor even under adequate thyroid hormone substitution, PHP Ia may be suspected, especially when symptoms of AHO are present.

  4. Postpubertal Persistent Hyperestrogenemia in McCune-Albright Syndrome: Unilateral Oophorectomy Improved Fertility but Detected an Unexpected Borderline Epithelial Ovarian Tumor.

    PubMed

    Chevalier, Nicolas; Paris, Françoise; Fontana, Sylvie; Delotte, Jérôme; Gaspari, Laura; Ferrari, Patricia; Sultan, Charles; Fénichel, Patrick

    2015-12-01

    McCune-Albright syndrome (MAS), due to a somatic mutation of the GNAS1 gene, begins usually in girls with peripheral precocious puberty. Ovarian autonomy may persist in adulthood with acyclic hyperestrogenemia, infertility, and a potential risk of estrogen-dependent cancer. A 22-year-old woman, with MAS, was referred for infertility with left macropolycystic ovary, hyperestrogenemia, and chronic anovulation unsuccessfully treated by controlled hyperstimulation. Once ovarian cyst punctures and cDNA analysis verified that GNAS1 mutation was restricted to the left ovary, unilateral ovariectomy was performed. It improved right ovarian function, allowed an in vitro fertilization-induced pregnancy, but revealed an unexpected borderline epithelial ovarian tumor. Several breast cancers have already been reported in young MAS patients but not a borderline epithelial ovarian tumor. In this context, we would recommend that persistent hyperestrogenemia in an adult be corrected and gynecological follow-up of the breasts, ovaries, and endometrium be implemented. Copyright © 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  5. RDCI, the vasoactive intestinal peptide receptor: a candidate gene for the features of Albright hereditary osteodystrophy associated with deletion of 2q37.

    PubMed Central

    Power, M M; James, R S; Barber, J C; Fisher, A M; Wood, P J; Leatherdale, B A; Flanagan, D E; Hatchwell, E

    1997-01-01

    Albright hereditary osteodystrophy (AHO) is an autosomal dominant disorder characterised by the presence of brachymetaphalangism, short stature, obesity, and mental retardation. Variable biochemical changes many represent either pseudohypoparathyroidism (PHP) owing to resistance to parathormone (PTH) or pseudopseudohypoparathyroidism (PPHP) with no hormone resistance. In most cases of AHO, reduced levels of Gs alpha have been found and a number of deactivating mutations in the gene for Gs alpha located on chromosome 20q13 have been described. Recently a number of people with an AHO-like phenotype have been reported in whom a deletion of chromosomal region 2q37 has been found in the absence of biochemical abnormalities or a reduction in Gs alpha activity. We present a further female patient with a cytogenetically visible deletion of 2q37, an AHO-like phenotype, and unusual biochemistry suggesting moderate PTH resistance. The vasoactive intestinal peptide receptor (RDCI) has recently been mapped to 2q37 and we propose that this is a candidate gene, hemizygosity of which affects signal transduction and leads to the AHO-like phenotype found in patients with 2q37 deletions. Images PMID:9138150

  6. RDCI, the vasoactive intestinal peptide receptor: a candidate gene for the features of Albright hereditary osteodystrophy associated with deletion of 2q37.

    PubMed

    Power, M M; James, R S; Barber, J C; Fisher, A M; Wood, P J; Leatherdale, B A; Flanagan, D E; Hatchwell, E

    1997-04-01

    Albright hereditary osteodystrophy (AHO) is an autosomal dominant disorder characterised by the presence of brachymetaphalangism, short stature, obesity, and mental retardation. Variable biochemical changes many represent either pseudohypoparathyroidism (PHP) owing to resistance to parathormone (PTH) or pseudopseudohypoparathyroidism (PPHP) with no hormone resistance. In most cases of AHO, reduced levels of Gs alpha have been found and a number of deactivating mutations in the gene for Gs alpha located on chromosome 20q13 have been described. Recently a number of people with an AHO-like phenotype have been reported in whom a deletion of chromosomal region 2q37 has been found in the absence of biochemical abnormalities or a reduction in Gs alpha activity. We present a further female patient with a cytogenetically visible deletion of 2q37, an AHO-like phenotype, and unusual biochemistry suggesting moderate PTH resistance. The vasoactive intestinal peptide receptor (RDCI) has recently been mapped to 2q37 and we propose that this is a candidate gene, hemizygosity of which affects signal transduction and leads to the AHO-like phenotype found in patients with 2q37 deletions.

  7. Combining Real-Time COLD- and MAMA-PCR TaqMan Techniques to Detect and Quantify R201 GNAS Mutations in the McCune-Albright Syndrome
.

    PubMed

    de Sanctis, Luisa; Galliano, Ilaria; Montanari, Paola; Matarazzo, Patrizia; Tessaris, Daniele; Bergallo, Massimiliano

    2017-01-01

    The McCune-Albright syndrome (MAS) is a potentially severe disorder hallmarked by fibrous bone dysplasia, café-au-lait skin spots, and endocrine hyperfunction. It is caused by postzygotic activating mutations at the R201 codon of the GNAS gene, leading to a state of somatic mosaicism. Our aim was to improve the mutation detection rate and to quantify the presence of R201 GNAS mutations in different DNA samples from MAS patients. Real-time COLD- and MAMA-PCR TaqMan techniques were combined to search for R201 mutations in the DNA of blood or affected tissues from 16 previously molecularly characterized MAS patients, from a further 84 subjects with MAS signs who were R201 negative at RFLP analysis, and from 36 controls. The ability of this new method to provide quantitative data was tested in the serial dilution of wild-type, R201H, or R201C cloned plasmid DNA samples; the mutant abundance was measured by spectrophotometry. A linear correlation between the true and the relative mutant abundance was observed until 2.5%, indicating a reliable quantification of R201 mutations. The assay's sensitivity was 0.05%, similar to that of previously described molecular methods. The real-time COLD-MAMA-PCR approach is a rapid, efficient, and inexpensive molecular technique for the identification of mutant alleles poorly represented in DNA samples.
. © 2017 S. Karger AG, Basel.

  8. Space Station attached payloads

    NASA Technical Reports Server (NTRS)

    Clark, Lenwood G.

    1990-01-01

    The Space Station Freedom is being designed and developed with user requirements being used to shape the configuration. Plans include accommodation provisions for a wide variety of attached payloads including the Earth sciences research activities which are the focus of this conference. The station program is even beginning some preliminary payload manifesting which involves planning for accommodation of payload during the station's assembly flights. Potential payload organizations should be aware of the station's plans for payload accommodations so as to guide their own payload activities for future space station use.

  9. Neuroradiology viewing station

    NASA Astrophysics Data System (ADS)

    Lou, Shyhliang A.; Lufkin, Robert B.; Valentino, Daniel J.; Huang, H. K.; Hanafee, William; Jabour, Bradly; Bentsen, John R.; Duckwiler, Gary R.; Dion, Jacques E.

    1990-07-01

    A distributed CT/MR digital viewing station for the neuroradiology section has been developed and is being evaluated in our department. The major components of the station consist of a SUN host computer, a PIXAR II image processor, and four 1K x 1K progressive video monitors. The software modules operating in the station include an image acquisition process, a local database process, and an user image display and processing process. Functions provided by the station are described. Preliminary results obtained from clinical evaluation are reported. Future plans to refine the station are presented.

  10. Hydrogen Generator

    NASA Technical Reports Server (NTRS)

    1983-01-01

    A unit for producing hydrogen on site is used by a New Jersey Electric Company. The hydrogen is used as a coolant for the station's large generator; on-site production eliminates the need for weekly hydrogen deliveries. High purity hydrogen is generated by water electrolysis. The electrolyte is solid plastic and the control system is electronic. The technology was originally developed for the Gemini spacecraft.

  11. Automating existing stations

    SciTech Connect

    Little, J.E.

    1986-09-01

    The task was to automate 20 major compressor stations along ANR Pipeline Co.'s Southeastern and Southwestern pipelines in as many months. Meeting this schedule required standardized hardware and software design. Working with Bristol Babcock Co., ANR came up with an off-the-shelf station automation package suitable for a variety of compressor stations. The project involved 148 engines with 488,880-hp in the 20 stations. ANR Pipeline developed software for these engines and compressors, including horsepower prediction and efficiency. The system places processors ''intelligence'' at each station and engine to monitor and control operations. The station processor receives commands from the company's gas dispatch center at Detroit and informs dispatchers of alarms, conditions, and decision it makes. The automation system is controlled by the Detroit center through a central communications network. Operating orders from the center are sent to the station processor, which obeys orders using the most efficient means of operation at the station's disposal. In a malfunction, a control and communications backup system takes over. Commands and information are directly transmitted between the center and the individual compressor stations. Stations receive their orders based on throughput, with suction and discharge pressure overrides. Additionally, a discharge temperature override protects pipeline coatings.

  12. Space station molecular sieve development

    NASA Technical Reports Server (NTRS)

    Chang, C.; Rousseau, J.

    1986-01-01

    An essential function of a space environmental control system is the removal of carbon dioxide (CO2) from the atmosphere to control the partial pressure of this gas at levels lower than 3 mm Hg. The use of regenerable solid adsorbents for this purpose was demonstrated effectively during the Skylab mission. Earlier sorbent systems used zeolite molecular sieves. The carbon molecular sieve is a hydrophobic adsorbent with excellent potential for space station application. Although carbon molecular sieves were synthesized and investigated, these sieves were designed to simulate the sieving properties of 5A zeolite and for O2/N2 separation. This program was designed to develop hydrophobic carbon molecular sieves for CO2 removal from a space station crew environment. It is a first phase effort involved in sorbent material development and in demonstrating the utility of such a material for CO2 removal on space stations. The sieve must incorporate the following requirements: it must be hydrophobic; it must have high dynamic capacity for carbon dioxide at the low partial pressure of the space station atmosphere; and it must be chemiclly stable and will not generate contaminants.

  13. Automatic Weather Station (AWS) Lidar

    NASA Technical Reports Server (NTRS)

    Rall, Jonathan A.R.; Abshire, James B.; Spinhirne, James D.; Smith, David E. (Technical Monitor)

    2000-01-01

    An autonomous, low-power atmospheric lidar instrument is being developed at NASA Goddard Space Flight Center. This compact, portable lidar will operate continuously in a temperature controlled enclosure, charge its own batteries through a combination of a small rugged wind generator and solar panels, and transmit its data from remote locations to ground stations via satellite. A network of these instruments will be established by co-locating them at remote Automatic Weather Station (AWS) sites in Antarctica under the auspices of the National Science Foundation (NSF). The NSF Office of Polar Programs provides support to place the weather stations in remote areas of Antarctica in support of meteorological research and operations. The AWS meteorological data will directly benefit the analysis of the lidar data while a network of ground based atmospheric lidar will provide knowledge regarding the temporal evolution and spatial extent of Type la polar stratospheric clouds (PSC). These clouds play a crucial role in the annual austral springtime destruction of stratospheric ozone over Antarctica, i.e. the ozone hole. In addition, the lidar will monitor and record the general atmospheric conditions (transmission and backscatter) of the overlying atmosphere which will benefit the Geoscience Laser Altimeter System (GLAS). Prototype lidar instruments have been deployed to the Amundsen-Scott South Pole Station (1995-96, 2000) and to an Automated Geophysical Observatory site (AGO 1) in January 1999. We report on data acquired with these instruments, instrument performance, and anticipated performance of the AWS Lidar.

  14. Space station propulsion test bed

    NASA Technical Reports Server (NTRS)

    Briley, G. L.; Evans, S. A.

    1989-01-01

    A test bed was fabricated to demonstrate hydrogen/oxygen propulsion technology readiness for the intital operating configuration (IOC) space station application. The test bed propulsion module and computer control system were delivered in December 1985, but activation was delayed until mid-1986 while the propulsion system baseline for the station was reexamined. A new baseline was selected with hydrogen/oxygen thruster modules supplied with gas produced by electrolysis of waste water from the space shuttle and space station. As a result, an electrolysis module was designed, fabricated, and added to the test bed to provide an end-to-end simulation of the baseline system. Subsequent testing of the test bed propulsion and electrolysis modules provided an end-to-end demonstration of the complete space station propulsion system, including thruster hot firings using the oxygen and hydrogen generated from electrolysis of water. Complete autonomous control and operation of all test bed components by the microprocessor control system designed and delivered during the program was demonstrated. The technical readiness of the system is now firmly established.

  15. Space Station-Baseline Configuration

    NASA Technical Reports Server (NTRS)

    1989-01-01

    In response to President Reagan's directive to NASA to develop a permanent marned Space Station within a decade, part of the State of the Union message to Congress on January 25, 1984, NASA and the Administration adopted a phased approach to Station development. This approach provided an initial capability at reduced costs, to be followed by an enhanced Space Station capability in the future. This illustration depicts the baseline configuration, which features a 110-meter-long horizontal boom with four pressurized modules attached in the middle. Located at each end are four photovoltaic arrays generating a total of 75-kW of power. Two attachment points for external payloads are provided along this boom. The four pressurized modules include the following: A laboratory and habitation module provided by the United States; two additional laboratories, one each provided by the European Space Agency (ESA) and Japan; and an ESA-provided Man-Tended Free Flyer, a pressurized module capable of operations both attached to and separate from the Space Station core. Canada was expected to provide the first increment of a Mobile Serving System.

  16. A new Space Station power system

    NASA Technical Reports Server (NTRS)

    Landis, Geoffrey A.

    1988-01-01

    A new concept for a Space Station power system is proposed which reduces the drag effect of the solar panels and eliminates eclipsing by the Earth. The solar generator is physically separated from the Space Station, and power transmitted to the station by a microwave beam. The power station can thus be placed high enough that drag is not a significant factor. For a resonant orbit where the ratio of periods s:p is a ratio of odd integers, and the orbital planes nearly perpendicular, an orbit can be chosen such that the line of sight is never blocked if the lower orbit has an altitude greater than calculatable mininum. For the 1:3 resonance, this minimum altitude is 0.5 r(e). Finally, by placing the power station into a sun-synchronous orbit, it can be made to avoid shadowing by the Earth, thus providing continuous power.

  17. Space station, 1959 to . .

    NASA Astrophysics Data System (ADS)

    Butler, G. V.

    1981-04-01

    Early space station designs are considered, taking into account Herman Oberth's first space station, the London Daily Mail Study, the first major space station design developed during the moon mission, and the Manned Orbiting Laboratory Program of DOD. Attention is given to Skylab, new space station studies, the Shuttle and Spacelab, communication satellites, solar power satellites, a 30 meter diameter radiometer for geological measurements and agricultural assessments, the mining of the moons, and questions of international cooperation. It is thought to be very probable that there will be very large space stations at some time in the future. However, for the more immediate future a step-by-step development that will start with Spacelab stations of 3-4 men is envisaged.

  18. Space Station Freedom Utilization Conference

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The topics addressed in Space Station Freedom Utilization Conference are: (1) space station freedom overview and research capabilities; (2) space station freedom research plans and opportunities; (3) life sciences research on space station freedom; (4) technology research on space station freedom; (5) microgravity research and biotechnology on space station freedom; and (6) closing plenary.

  19. Photovoltaic central station step and touch potential considerations in grounding system design

    NASA Technical Reports Server (NTRS)

    Engmann, G.

    1983-01-01

    The probability of hazardous step and touch potentials is an important consideration in central station grounding system design. Steam turbine generating station grounding system design is based on accepted industry practices and there is extensive in-service experience with these grounding systems. A photovoltaic (PV) central station is a relatively new concept and there is limited experience with PV station grounding systems. The operation and physical configuration of a PV central station is very different from a steam electric station. A PV station bears some similarity to a substation and the PV station step and touch potentials might be addressed as they are in substation design. However, the PV central station is a generating station and it is appropriate to examine the effect that the differences and similarities of the two types of generating stations have on step and touch potential considerations.

  20. Alternative strategies for space station financing

    NASA Technical Reports Server (NTRS)

    Walklet, D. C.; Heenan, A. T.

    1983-01-01

    The attributes of the proposed space station program are oriented toward research activities and technologies which generate long term benefits for mankind. Unless such technologies are deemed of national interest and thus are government funded, they must stand on their own in the market place. Therefore, the objectives of a United States space station should be based on commercial criteria; otherwise, such a project attracts no long term funding. There is encouraging evidence that some potential space station activities should generate revenues from shuttle related projects within the decade. Materials processing concepts as well as remote sensing indicate substantial potential. Futhermore, the economics and thus the commercial feasibility of such projects will be improved by the operating efficiencies available with an ongoing space station program.

  1. Space station power system

    NASA Technical Reports Server (NTRS)

    Baraona, Cosmo R.

    1987-01-01

    The major requirements and guidelines that affect the space station configuration and power system are explained. The evolution of the space station power system from the NASA program development-feasibility phase through the current preliminary design phase is described. Several early station concepts are described and linked to the present concept. Trade study selections of photovoltaic system technologies are described in detail. A summary of present solar dynamic and power management and distribution systems is also given.

  2. Technology for space station

    NASA Astrophysics Data System (ADS)

    Colladay, R. S.; Carlisle, R. F.

    1984-10-01

    Some of the most significant advances made in the space station discipline technology program are examined. Technological tasks and advances in the areas of systems/operations, environmental control and life support systems, data management, power, thermal considerations, attitude control and stabilization, auxiliary propulsion, human capabilities, communications, and structures, materials, and mechanisms are discussed. An overview of NASA technology planning to support the initial space station and the evolutionary growth of the space station is given.

  3. Optimization of station battery replacement

    NASA Astrophysics Data System (ADS)

    Jancauskas, J. R.; Shook, D. A.

    1994-08-01

    During a loss of ac power at a nuclear generating station (including diesel generators), batteries provide the source of power which is required to operate safety-related components. Because traditional lead-acid batteries have a qualified life of 20 years, the batteries must be replaced a minimum of once during a station's lifetime, twice if license extension is pursued, and more often depending on actual in-service dates and the results of surveillance tests. Replacement of batteries often occurs prior to 20 years as a result of systems changes caused by factors such as Station Blackout Regulations, control system upgrades, incremental load growth, and changes in the operating times of existing equipment. Many of these replacement decisions are based on the predictive capabilities of manual design basis calculations. The inherent conservatism of manual calculations may result in battery replacements occurring before actually required. Computerized analysis of batteries can aid in optimizing the timing of replacements as well as in interpreting service test data. Computerized analysis also provides large benefits in maintaining the as-configured load profile and corresponding design margins, while also providing the capability to quickly analyze proposed modifications and respond to internal and external audits.

  4. Space Station operations

    NASA Technical Reports Server (NTRS)

    Gray, R. H.

    1985-01-01

    An evaluation of the success of the Space Station will be based on the service provided to the customers by the Station crew, the productivity of the crew, and the costs of operation. Attention is given to details regarding Space Station operations, a summary of operational philosophies and requirements, logistics and resupply operations, prelaunch processing and launch operations, on-orbit operations, aspects of maintainability and maintenance, habitability, and questions of medical care. A logistics module concept is considered along with a logistics module processing timeline, a habitability module concept, and a Space Station rescue mission.

  5. Control of space stations

    NASA Technical Reports Server (NTRS)

    Lee, K. Y.

    1983-01-01

    A study is made to develop controllers for the NASA-JSC Triangular Space Station and evaluate their performances to make recommendations for structural design and/or control alternatives. The control system design assumes the rigid body of the Space Station and developes the lumped parameter control system by using the Inverse Optimal Control Theory. In order to evaluate the performance of the control system, a Parameter Estimation algorithm is being developed which will be used in modeling an equivalent but simpler Space Station model. Finally, a scaled version of the Space Station is being built for the purpose of physical experiments to evaluate the control system performance.

  6. Space Station fluid resupply

    NASA Astrophysics Data System (ADS)

    Winters, Al

    Viewgraphs on space station fluid resupply are presented. Space Station Freedom is resupplied with supercritical O2 and N2 for the ECLSS and USL on a 180 day resupply cycle. Resupply fluids are stored in the subcarriers on station between resupply cycles and transferred to the users as required. ECLSS contingency fluids (O2 and N2) are supplied and stored on station in a gaseous state. Efficiency and flexibility are major design considerations. Subcarrier approach allows multiple manifest combinations. Growth is achieved by adding modular subcarriers.

  7. Station Crew Celebrates Christmas

    NASA Image and Video Library

    Aboard the orbiting International Space Station, Expedition 34 Commander Kevin Ford, Russian Flight Engineers Oleg Novitskiy, Evgeny Tarelkin and Roman Romanenko, NASA Flight Engineer Tom Marshburn...

  8. Infrared monitoring of the Space Station environment

    NASA Technical Reports Server (NTRS)

    Kostiuk, Theodor; Jennings, Donald E.; Mumma, Michael J.

    1988-01-01

    The measurement and monitoring of infrared emission in the environment of the Space Station has a twofold importance - for the study of the phenomena itself and as an aid in planning and interpreting Station based infrared experiments. Spectral measurements of the infrared component of the spacecraft glow will, along with measurements in other spectral regions, provide data necessary to fully understand and model the physical and chemical processes producing these emissions. The monitoring of the intensity of these emissions will provide background limits for Space Station based infrared experiments and permit the determination of optimum instrument placement and pointing direction. Continuous monitoring of temporal changes in the background radiation (glow) will also permit better interpretation of Station-based infrared earth sensing and astronomical observations. The primary processes producing infrared emissions in the Space Station environment are: (1) Gas phase excitations of Station generated molecules ( e.g., CO2, H2O, organics...) by collisions with the ambient flux of mainly O and N2. Molecular excitations and generation of new species by collisions of ambient molecules with Station surfaces. They provide a list of resulting species, transition energies, excitation cross sections and relevant time constants. The modeled spectrum of the excited species occurs primarily at wavelengths shorter than 8 micrometer. Emissions at longer wavelengths may become important during rocket firing or in the presence of dust.

  9. Data quality control of ADSN Broadband stations

    NASA Astrophysics Data System (ADS)

    Alili, Azouaou; Yelles-chaouche, Abd el karim; Allili, Toufik; Messemen, Walid

    2014-05-01

    In this work we present the analysis of continuous waveform of the Algerian digital seismic network recorded during five years from 2008 to 2013 for twenty broadband stations using the power spectral densities (PSDs) and their corresponding probability density functions (PDFs) algorithm of McNamara, and Buland (2004). ADSN Broadband stations data quality is one main concern and interest of ADSN technical team. Indeed, the quality of the data from broadband stations is continuously controlled in quasi-realtime using "PQLX" (Pascal Quick Look eXtended) software to compute the PDFs and PSDs during the operation of the stations at different frequency range. At each station the level of noise is shown, which we can see diurnal and seasonal variation. From the data analysis, most of the ADSN Broadband stations display good records in the several frequency domains in relation with their site installation. However some of stations near the urban areas could present some noisy disturbances. This led sometimes to generate some ghost events. In the low frequency, some stations could be still influenced by the temperature variations. This long period of records from 2008 to 2013, led us to analyze and control the several stations year by year taking into account the seasons and to know about their work during five years. This analysis is also very important to improve in the future quality of station installation and choose the optimal station design in aim to reduce cultural noise and large fluctuation of temperature and pressure. Key words: PQLX, PDFs, PSDs, Broad Band

  10. Contamination of optical surfaces. [Space Station

    NASA Technical Reports Server (NTRS)

    Arnold, Graham S.; Hall, David F.

    1988-01-01

    The effect of molecular contamination on Space Station optical surfaces is examined. In particular, contamination of solar voltaic power sources and optical solar reflectors for thermal control or solar dynamic power generation is addressed. The published Space Station requirements for molecular contamination accretion and for the monitoring of such accretion is discussed in the context of the historical performance of space systems. Specific reference is made to the results from the Spacecraft Charging at High Altitudes (SCATHA) ML12 experiment.

  11. International Space Station (ISS)

    NASA Image and Video Library

    2001-02-01

    The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient, and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This photograph shows the fifth generation Urine Processor Development Hardware. The Urine Processor Assembly (UPA) is a part of the Water Recovery System (WRS) on the ISS. It uses a chase change process called vapor compression distillation technology to remove contaminants from urine. The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the Water Processor Assembly (WPA). The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. Product water quality is monitored primarily through conductivity measurements. Unacceptable water is sent back through the WPA for reprocessing. Clean water is sent to a storage tank.

  12. International Space Station (ISS)

    NASA Image and Video Library

    2001-03-01

    The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This photograph shows the mockup of the the ECLSS to be installed in the Node 3 module of the ISS. From left to right, shower rack, waste management rack, Water Recovery System (WRS) Rack #2, WRS Rack #1, and Oxygen Generation System (OGS) rack are shown. The WRS provides clean water through the reclamation of wastewaters and is comprised of a Urine Processor Assembly (UPA) and a Water Processor Assembly (WPA). The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the WPA. The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. The OGS produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen loss. The OGS is comprised of a cell stack, which electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the WRS, and the separators that remove the gases from the water after electrolysis.

  13. "Life without nuclear power": A nuclear plant retirement formulation model and guide based on economics. San Onofre Nuclear Generating Station case: Economic impacts and reliability considerations leading to plant retirement

    NASA Astrophysics Data System (ADS)

    Wasko, Frank

    Traditionally, electric utilities have been slow to change and very bureaucratic in nature. This culture, in and of itself, has now contributed to a high percentage of United States electric utilities operating uneconomical nuclear plants (Crooks, 2014). The economic picture behind owning and operating United States nuclear plants is less than favorable for many reasons including rising fuel, capital and operating costs (EUCG, 2012). This doctoral dissertation is specifically focused on life without nuclear power. The purpose of this dissertation is to create a model and guide that will provide electric utilities who currently operate or will operate uneconomical nuclear plants the opportunity to economically assess whether or not their nuclear plant should be retired. This economic assessment and stakeholder analysis will provide local government, academia and communities the opportunity to understand how Southern California Edison (SCE) embraced system upgrade import and "voltage support" opportunities to replace "base load" generation from San Onofre Nuclear Generating Station (SONGS) versus building new replacement generation facilities. This model and guide will help eliminate the need to build large replacement generation units as demonstrated in the SONGS case analysis. The application of The Nuclear Power Retirement Model and Guide will provide electric utilities with economic assessment parameters and an evaluation assessment progression needed to better evaluate when an uneconomical nuclear plant should be retired. It will provide electric utilities the opportunity to utilize sound policy, planning and development skill sets when making this difficult decision. There are currently 62 nuclear power plants (with 100 nuclear reactors) operating in the United States (EIA, 2014). From this group, 38 are at risk of early retirement based on the work of Cooper (2013). As demonstrated in my model, 35 of the 38 nuclear power plants qualify to move to the economic

  14. Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.

    PubMed Central

    Schwindinger, W F; Francomano, C A; Levine, M A

    1992-01-01

    McCune-Albright syndrome (MAS) is characterized by polyostotic fibrous dysplasia, café-au-lait lesions, and a variety of endocrine disorders, including precocious puberty, hyperthyroidism, hypercortisolism, growth hormone excess, and hyperprolactinemia. The diverse metabolic abnormalities seen in MAS share the involvement of cells that respond to extracellular signals through activation of the hormone-sensitive adenylyl cyclase system (EC 4.6.1.1). Mutations that lead to constitutive activation of Gs alpha, the guanine nucleotide-binding regulatory protein that stimulates adenylyl cyclase activity, have been identified in a subset of human growth hormone-secreting pituitary tumors and human thyroid tumors. We report here the identification of a mutation in the gene encoding Gs alpha in a patient with MAS. Denaturing gradient gel electrophoresis was used to analyze amplified DNA fragments including exon 8 or exon 9 of the Gs alpha gene. In one subject with MAS a G-to-A transition was found in exon 8 of one of the two alleles encoding Gs alpha. This single-base substitution results in the replacement of arginine by histidine at position 201 of the mature Gs alpha protein. Semiquantitative analysis of amplified DNA indicated that the mutant allele was less prevalent than the wild-type allele in peripheral leukocytes and was present in very low levels in skin. These findings support the previous contention that the segmental distribution and variable expression of the cutaneous, skeletal, and endocrine manifestations of MAS reflect an underlying somatic mosaicism. Further, these results suggest that the molecular basis of MAS is a postzygotic mutation in Gs alpha that causes constitutive activation of adenylyl cyclase. Images PMID:1594625

  15. "Inventive" Learning Stations

    ERIC Educational Resources Information Center

    Jarrett, Olga

    2010-01-01

    Learning stations can be used for myriad purposes--to teach concepts, integrate subject matter, build interest, and allow for inquiry--the possibilities are limited only by the imagination of the teacher and the supplies available. In this article, the author shares suggestions and a checklist for setting up successful learning stations. In…

  16. International Space Station (ISS)

    NASA Image and Video Library

    2006-07-06

    Though very close to the International Space Station, the majority of Discovery's underside is visible in this frame. The image was captured by one of the Expedition 13 crew members onboard the International Space Station (ISS) during the STS-121 Rotating Pitch Maneuver (RPM) survey prior to docking of the two spacecraft.

  17. Summit Station Skiway Review

    DTIC Science & Technology

    2013-03-01

    delivery of personnel and materials, is by skied airplanes (currently Twin Otters and LC-130s) or by annual traverse. To support aircraft, the station...Station during the first sea - son (2009) of skiway construction at Pegasus Airfield (Haehnel et al. 2013) but consistently lower than densities of

  18. International Space Station (ISS)

    NASA Image and Video Library

    2007-08-13

    Back dropped by the blue and white Earth is a Materials International Space Station Experiment (MISSE) on the exterior of the Station. The photograph was taken during the second bout of STS-118 Extra Vehicular Activity (EVA). MISSE collects information on how different materials weather in the environment of space.

  19. International Space Station (ISS)

    NASA Image and Video Library

    2000-12-01

    This image of the International Space Station in orbit was taken from the Space Shuttle Endeavour prior to docking. Most of the Station's components are clearly visible in this photograph. They are the Node 1 or Unity Module docked with the Functional Cargo Block or Zarya (top) that is linked to the Zvezda Service Module. The Soyuz spacecraft is at the bottom.

  20. "Inventive" Learning Stations

    ERIC Educational Resources Information Center

    Jarrett, Olga

    2010-01-01

    Learning stations can be used for myriad purposes--to teach concepts, integrate subject matter, build interest, and allow for inquiry--the possibilities are limited only by the imagination of the teacher and the supplies available. In this article, the author shares suggestions and a checklist for setting up successful learning stations. In…

  1. Space station dynamics

    NASA Technical Reports Server (NTRS)

    Berka, Reg

    1990-01-01

    Structural dynamic characteristics and responses of the Space Station due to the natural and induced environment are discussed. Problems that are peculiar to the Space Station are also discussed. These factors lead to an overall acceleration environment that users may expect. This acceleration environment can be considered as a loading, as well as a disturbance environment.

  2. Pamidronic acid and cabergoline as effective long-term therapy in a 12-year-old girl with extended facial polyostotic fibrous dysplasia, prolactinoma and acromegaly in McCune-Albright syndrome: a case report.

    PubMed

    Classen, Carl Friedrich; Mix, Monika; Kyank, Ulrike; Hauenstein, Christina; Haffner, Dieter

    2012-01-24

    McCune-Albright syndrome is a complex inborn disorder due to early embryonal postzygotic somatic activating mutations in the GNAS1 gene. The phenotype is very heterogeneous and includes polyostotic fibrous dysplasia, typically involving the facial skull, numerous café-au-lait spots and autonomous hyperfunctions of several endocrine systems, leading to hyperthyroidism, hypercortisolism, precocious puberty and acromegaly. Here, we describe a 12-year-old Caucasian girl with severe facial involvement of fibrous dysplasia, along with massive acromegaly due to growth hormone excess and precocious puberty, with a prolactinoma. Our patient was treated with a bisphosphonate and the prolactin antagonist, cabergoline, resulting in the inhibition of fibrous dysplasia and involution of both the prolactinoma and growth hormone excess. During a follow-up of more than two years, no severe side effects were noted. Treatment with bisphosphonates in combination with cabergoline is a suitable option in patients with McCune-Albright syndrome, especially in order to circumvent surgical interventions in patients suffering from polyostotic fibrous dysplasia involving the skull base.

  3. Pamidronic acid and cabergoline as effective long-term therapy in a 12-year-old girl with extended facial polyostotic fibrous dysplasia, prolactinoma and acromegaly in McCune-Albright syndrome: a case report

    PubMed Central

    2012-01-01

    Introduction McCune-Albright syndrome is a complex inborn disorder due to early embryonal postzygotic somatic activating mutations in the GNAS1 gene. The phenotype is very heterogeneous and includes polyostotic fibrous dysplasia, typically involving the facial skull, numerous café-au-lait spots and autonomous hyperfunctions of several endocrine systems, leading to hyperthyroidism, hypercortisolism, precocious puberty and acromegaly. Case presentation Here, we describe a 12-year-old Caucasian girl with severe facial involvement of fibrous dysplasia, along with massive acromegaly due to growth hormone excess and precocious puberty, with a prolactinoma. Our patient was treated with a bisphosphonate and the prolactin antagonist, cabergoline, resulting in the inhibition of fibrous dysplasia and involution of both the prolactinoma and growth hormone excess. During a follow-up of more than two years, no severe side effects were noted. Conclusion Treatment with bisphosphonates in combination with cabergoline is a suitable option in patients with McCune-Albright syndrome, especially in order to circumvent surgical interventions in patients suffering from polyostotic fibrous dysplasia involving the skull base. PMID:22273876

  4. International Space Station (ISS)

    NASA Image and Video Library

    2002-04-16

    Docked to the International Space Station (ISS), a Soyuz vehicle (foreground) and the Space Shuttle Atlantis were photographed by a crew member in the Pirs docking compartment on the orbital outpost. Atlantis launched on April 8, 2002, carrying the the STS-110 mission which prepared the ISS for future space walks by installing and outfitting the 43-foot-long Starboard side S0 (S-zero) truss and preparing the first railroad in space, the Mobile Transporter. The 27,000 pound S0 truss was the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. This central truss segment also includes a flatcar called the Mobile Transporter and rails that will become the first "space railroad," which will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. STS-110 Extravehicular Activity (EVA) marked the first use of the Station's robotic arm to maneuver space walkers around the Station and was the first time all of a shuttle crew's scapulas were based out of the Station's Quest Airlock.

  5. International Space Station (ISS)

    NASA Image and Video Library

    2001-03-13

    Astronaut Paul W. Richards, STS-102 mission specialist, works in the cargo bay of the Space Shuttle Discovery during the second of two scheduled space walks. Richards, along with astronaut Andy Thomas, spent 6.5 hours outside the International Space Station (ISS), continuing work to outfit the station and prepare for delivery of its robotic arm. STS-102 delivered the first Multipurpose Logistics Modules (MPLM) named Leonardo, which was filled with equipment and supplies to outfit the U.S. Destiny Laboratory Module. The Leonardo MPLM is the first of three such pressurized modules that will serve as the ISS' moving vans, carrying laboratory racks filled with equipment, experiments, and supplies to and from the Station aboard the Space Shuttle. The cylindrical module is approximately 21-feet long and 15- feet in diameter, weighing almost 4.5 tons. It can carry up to 10 tons of cargo in 16 standard Space Station equipment racks. Of the 16 racks the module can carry, 5 can be furnished with power, data, and fluid to support refrigerators or freezers. In order to function as an attached station module as well as a cargo transport, the logistics module also includes components that provide life support, fire detection and suppression, electrical distribution, and computer functions. NASA's 103rd overall mission and the 8th Space Station Assembly Flight, STS-102 mission also served as a crew rotation flight. It delivered the Expedition Two crew to the Station and returned the Expedition One crew back to Earth.

  6. Overview of guideway, Pratt Street Station, Bridge Street Station and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Overview of guideway, Pratt Street Station, Bridge Street Station and train yard, looking east. Dyre street in foreground. - Frankford Elevated, 52100-5400 Frankford Avenue (guideway & stations), Philadelphia, Philadelphia County, PA

  7. 4. EASTBOUND VIEW. NORTH TRACK WAITING STATION ON LEFT. STATION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. EASTBOUND VIEW. NORTH TRACK WAITING STATION ON LEFT. STATION ON RIGHT. NOTE TUNNEL IN BACKGROUND. - Baltimore & Ohio Railroad, Harpers Ferry Station, Potomac Street, Harpers Ferry, Jefferson County, WV

  8. About the Smart Weather Station

    NASA Astrophysics Data System (ADS)

    Bogdan, Mihai

    2016-12-01

    Until recently, the Romanian weather stations utilized ordinary transducers that acquire useful information related to the desired physical inputs. These inputs will be converted into electrical signals easy to be processed by analog to digital converters. This paper proposed a new approach based on smart sensors system that change the interior behavior in order to optimize data acquirements from the environment. The smart sensor characteristics are stored into himself in a transducer electronic data sheet form (TEDS). The intelligent transducer generat together with the measured analogic signal also a digital interface. Through this interface the transducer's catalog data can be read from the transducer.

  9. Station Climatic Summaries, Asia

    DTIC Science & Technology

    1989-07-01

    MANDALAY 480420 8809 (OCDS) .................................................. .022 MYITKYINA 480080 8809 (OCDS...0 1 0 0 0 2 0 5 2 1 06-20 LST 8 3 # 1 # 1 1 2 4 10 11 13 4 ECR-KRW-7a OZi OPERATIONAL CLIMATIC DATA SUMMARY STATION: MANDALAY , BM STATION #: 480420...18-20 LST # 0 # 0 # 1 0 2 1 # 1 1 1 06-20 LST 1 2 2 1 1 1 2 1 1 1 2 5 1 ECR-KRW-6 oZ3 OPERATIONAL CLIMATIC DATA SUPPLEMENT STATION: MANDALAY , BM

  10. International Space Station (ISS)

    NASA Image and Video Library

    1997-06-01

    Artist's digital concept of the International Space Station (ISS), a gateway to permanent human presence in space, after all assembly is completed in Year 2003. The Station will be powered by almost an acre of solar panels and have a mass of almost one million pounds. Station modules are being provided by the United States, Russia, Japan, and Europe. Canada is providing a mechanical arm and Canada Hand. Sixteen countries are cooperating to provide a multidisciplinary laboratory, technology test bed, and observatory that will provide an unprecedented undertaking in scientific, technological, and international experimentation.

  11. Madrid space station

    NASA Technical Reports Server (NTRS)

    Fahnestock, R. J.; Renzetti, N. A.

    1975-01-01

    The Madrid space station, operated under bilateral agreements between the governments of the United States and Spain, is described in both Spanish and English. The space station utilizes two tracking and data acquisition networks: the Deep Space Network (DSN) of the National Aeronautics and Space Administration and the Spaceflight Tracking and Data Network (STDN) operated under the direction of the Goddard Space Flight Center. The station, which is staffed by Spanish employees, comprises four facilities: Robledo 1, Cebreros, and Fresnedillas-Navalagamella, all with 26-meter-diameter antennas, and Robledo 2, with a 64-meter antenna.

  12. The space station

    NASA Technical Reports Server (NTRS)

    Munoz, Abraham

    1988-01-01

    Conceived since the beginning of time, living in space is no longer a dream but rather a very near reality. The concept of a Space Station is not a new one, but a redefined one. Many investigations on the kinds of experiments and work assignments the Space Station will need to accommodate have been completed, but NASA specialists are constantly talking with potential users of the Station to learn more about the work they, the users, want to do in space. Present configurations are examined along with possible new ones.

  13. Space Station Induced Monitoring

    NASA Technical Reports Server (NTRS)

    Spann, James F. (Editor); Torr, Marsha R. (Editor)

    1988-01-01

    This report contains the results of a conference convened May 10-11, 1988, to review plans for monitoring the Space Station induced environment, to recommend primary components of an induced environment monitoring package, and to make recommendations pertaining to suggested modifications of the Space Station External Contamination Control Requirements Document JSC 30426. The contents of this report are divided as Follows: Monitoring Induced Environment - Space Station Work Packages Requirements, Neutral Environment, Photon Emission Environment, Particulate Environment, Surface Deposition/Contamination; and Contamination Control Requirements.

  14. Space station operations management

    NASA Technical Reports Server (NTRS)

    Cannon, Kathleen V.

    1989-01-01

    Space Station Freedom operations management concepts must be responsive to the unique challenges presented by the permanently manned international laboratory. Space Station Freedom will be assembled over a three year period where the operational environment will change as significant capability plateaus are reached. First Element Launch, Man-Tended Capability, and Permanent Manned Capability, represent milestones in operational capability that is increasing toward mature operations capability. Operations management concepts are being developed to accomodate the varying operational capabilities during assembly, as well as the mature operational environment. This paper describes operations management concepts designed to accomodate the uniqueness of Space Station Freedoom, utilizing tools and processes that seek to control operations costs.

  15. Crew interface with a telerobotic control station

    NASA Technical Reports Server (NTRS)

    Mok, Eva

    1987-01-01

    A method for apportioning crew-telerobot tasks has been derived to facilitate the design of a crew-friendly telerobot control station. To identify the most appropriate state-of-the-art hardware for the control station, task apportionment must first be conducted to identify if an astronaut or a telerobot is best to execute the task and which displays and controls are required for monitoring and performance. Basic steps that comprise the task analysis process are: (1) identify space station tasks; (2) define tasks; (3) define task performance criteria and perform task apportionment; (4) verify task apportionment; (5) generate control station requirements; (6) develop design concepts to meet requirements; and (7) test and verify design concepts.

  16. Enabler operator station

    NASA Technical Reports Server (NTRS)

    Bailey, Andrea; Kietzman, John; King, Shirlyn; Stover, Rae; Wegner, Torsten

    1992-01-01

    The objective of this project was to design an onboard operator station for the conceptual Lunar Work Vehicle (LWV). The LWV would be used in the colonization of a lunar outpost. The details that follow, however, are for an Earth-bound model. The operator station is designed to be dimensionally correct for an astronaut wearing the current space shuttle EVA suit (which include life support). The proposed operator station will support and restrain an astronaut as well as to provide protection from the hazards of vehicle rollover. The threat of suit puncture is eliminated by rounding all corners and edges. A step-plate, located at the front of the vehicle, provides excellent ease of entry and exit. The operator station weight requirements are met by making efficient use of rigid members, semi-rigid members, and woven fabrics.

  17. Space Station Software Recommendations

    NASA Technical Reports Server (NTRS)

    Voigt, S. (Editor)

    1985-01-01

    Four panels of invited experts and NASA representatives focused on the following topics: software management, software development environment, languages, and software standards. Each panel deliberated in private, held two open sessions with audience participation, and developed recommendations for the NASA Space Station Program. The major thrusts of the recommendations were as follows: (1) The software management plan should establish policies, responsibilities, and decision points for software acquisition; (2) NASA should furnish a uniform modular software support environment and require its use for all space station software acquired (or developed); (3) The language Ada should be selected for space station software, and NASA should begin to address issues related to the effective use of Ada; and (4) The space station software standards should be selected (based upon existing standards where possible), and an organization should be identified to promulgate and enforce them. These and related recommendations are described in detail in the conference proceedings.

  18. Space station data flow

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The results of the space station data flow study are reported. Conceived is a low cost interactive data dissemination system for space station experiment data that includes facility and personnel requirements and locations, phasing requirements and implementation costs. Each of the experiments identified by the operating schedule is analyzed and the support characteristics identified in order to determine data characteristics. Qualitative and quantitative comparison of candidate concepts resulted in a proposed data system configuration baseline concept that includes a data center which combines the responsibility of reprocessing, archiving, and user services according to the various agencies and their responsibility assignments. The primary source of data is the space station complex which provides through the Tracking Data Relay Satellite System (TDRS) and by space shuttle delivery data from experiments in free flying modules and orbiting shuttles as well as from the experiments in the modular space station itself.

  19. The Space Station Chronicles

    NASA Image and Video Library

    As early as the nineteenth century, writers and artists and scientists around the world began to publish their visions of a crewed outpost in space. Learn about the history of space stations, from ...

  20. Station Assembly Animation

    NASA Image and Video Library

    This animation depicts the assembly of the International Space Station since Nov. 20, 1998, with the delivery of the Zarya module, through May 16, 2011, with the delivery of the EXPRESS Logistics C...

  1. Space station propulsion technology

    NASA Technical Reports Server (NTRS)

    Briley, G. L.

    1986-01-01

    The progress on the Space Station Propulsion Technology Program is described. The objectives are to provide a demonstration of hydrogen/oxygen propulsion technology readiness for the Initial Operating Capability (IOC) space station application, specifically gaseous hydrogen/oxygen and warm hydrogen thruster concepts, and to establish a means for evolving from the IOC space station propulsion to that required to support and interface with advanced station functions. The evaluation of concepts was completed. The accumulator module of the test bed was completed and, with the microprocessor controller, delivered to NASA-MSFC. An oxygen/hydrogen thruster was modified for use with the test bed and successfully tested at mixture ratios from 4:1 to 8:1.

  2. Station Commander Praises AMS

    NASA Image and Video Library

    When asked what's the most important International Space Station experiment, Commander Chris Hadfield names the Alpha Magnetic Spectrometer-2, a state-of-the-art particle physics detector that coul...

  3. Multiple Craft Stations.

    ERIC Educational Resources Information Center

    Johns, Mary Sue

    1980-01-01

    Described are three craft stations (claywork, papermaking, and stamp designing) for intermediate grade students, to correlate with their classroom study which focused on Ohio: its history, geography, cities, industries, products and famous natives. (KC)

  4. Space Station Food System

    NASA Technical Reports Server (NTRS)

    Thurmond, Beverly A.; Gillan, Douglas J.; Perchonok, Michele G.; Marcus, Beth A.; Bourland, Charles T.

    1986-01-01

    A team of engineers and food scientists from NASA, the aerospace industry, food companies, and academia are defining the Space Station Food System. The team identified the system requirements based on an analysis of past and current space food systems, food systems from isolated environment communities that resemble Space Station, and the projected Space Station parameters. The team is resolving conflicts among requirements through the use of trade-off analyses. The requirements will give rise to a set of specifications which, in turn, will be used to produce concepts. Concept verification will include testing of prototypes, both in 1-g and microgravity. The end-item specification provides an overall guide for assembling a functional food system for Space Station.

  5. Enabler operator station

    NASA Astrophysics Data System (ADS)

    Bailey, Andrea; Keitzman, John; King, Shirlyn; Stover, Rae; Wegner, Torsten

    The objective of this project was to design an onboard operator station for the conceptual Lunar Work Vehicle (LWV). This LWV would be used in the colonization of a lunar outpost. The details that follow, however, are for an earth-bound model. Several recommendations are made in the appendix as to the changes needed in material selection for the lunar environment. The operator station is designed dimensionally correct for an astronaut wearing the current space shuttle EVA suit (which includes life support). The proposed operator station will support and restrain an astronaut as well as provide protection from the hazards of vehicle rollover. The threat of suit puncture is eliminated by rounding all corners and edges. A step-plate, located at the front of the vehicle, provides excellent ease of entry and exit. The operator station weight requirements are met by making efficient use of grid members, semi-rigid members and woven fabrics.

  6. International Space Station (ISS)

    NASA Image and Video Library

    1994-04-20

    An artist's concept of a fully deployed International Space Station (ISS) Alpha. The ISS-A is a multidisciplinary laboratory, technology test bed, and observatory that will provide an unprecedented undertaking in scientific, technological, and international experiments.

  7. International Space Station (ISS)

    NASA Image and Video Library

    2000-02-01

    A section of the International Space Station truss assembly arrived at the Marshall Space Flight Center on NASA's Super Guppy cargo plane for structural and design testing as well as installation of critical flight hardware.

  8. International Space Station (ISS)

    NASA Image and Video Library

    2000-12-01

    This image of the International Space Station (ISS) in orbit was taken during a fly-around inspection by the Space Shuttle Endeavour after successfull attachment of the 240-foot-long, 38-foot-wide solar array.

  9. International Space Station (ISS)

    NASA Image and Video Library

    1994-09-21

    Artist's concept of the final configuration of the International Space Station (ISS) Alpha. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide an unprecedented undertaking in scientific, technological, and international experimentation.

  10. Space Station Live! Tour

    NASA Image and Video Library

    NASA is using the Internet and smartphones to provide the public with a new inside look at what happens aboard the International Space Station and in the Mission Control Center. NASA Public Affairs...

  11. Space Station Software Issues

    NASA Technical Reports Server (NTRS)

    Voigt, S. (Editor); Beskenis, S. (Editor)

    1985-01-01

    Issues in the development of software for the Space Station are discussed. Software acquisition and management, software development environment, standards, information system support for software developers, and a future software advisory board are addressed.

  12. Destination Station Atlanta

    NASA Image and Video Library

    Destination Station was recently in Atlanta from April 15 through April 21. During the week, NASA visited schools, hospitals, museums, and the city’s well known Atlanta Science Tavern Meet Up gro...

  13. Applicability of Virtual Reference Stations for Static and Kinematic Positioning

    NASA Astrophysics Data System (ADS)

    Kalita, Jakub; Rzepecka, Zofia

    2013-04-01

    There is a possibility to generate artificial observations for a particular position by using a known Virtual Reference Station technique. It is done by transferring the observations from a physical reference station and interpolating the biases, usually using a network of reference stations. Theoretically, the measurements can replace the physical reference receiver and both, simplify and improve the processing of static and kinematic measurements. Here, the VRS is used as a control station for static and kinematic post-processing taking advantage of the network of reference stations by interpolating ionospheric and tropospheric biases to location of measurement. However previous computational experiments showed that the generated virtual observations are strongly correlated with the observations gathered at the nearest physical reference station. The previous studies were performed at close vicinity of the physical reference station. For further investigations of these correlations, and the issue of how do they influence processing results, a field experiment was designed and performed, in which the real measurements were taken at various distances from the physical reference station. Basing on these measurements, the correlations between the reference station and VRS stations were studied. The unknown physical stations were determined and used as a comparison for VRS measurements. Also, the applicability of VRS observations for static and kinematic processing was validated. To assure independence of calculations and results, besides commercial software (GNSS Solutions and LGO) chosen Precise Point Positioning services were used. The VRS data were obtained from the POZGEO-D service of the ASG-EUPOS network.

  14. International Space Station (ISS)

    NASA Image and Video Library

    2000-10-01

    Not long after separation of the Space Shuttle Discovery from the International Space Station (ISS), a crew member was able to use a 70mm handheld camera to grab this image of the station, featuring its newest additions. Backdropped against the blackness of space, the Z1 truss structure and its anterna, as well as the new Pressurized Mating Adapter (PMA-3), are visible in the foreground.

  15. International Space Station (ISS)

    NASA Image and Video Library

    2001-04-28

    A Canadian "handshake" in space occurred on April 28, 2001, as the Canadian-built space station robotic arm (Canadarm-2) transferred its launch cradle over to Endeavor's robotic arm. Marning the controls from the shuttle's aft flight deck, Canadian Mission Specialist Chris A. Hadfield of the Canadian Space Agency (CSA) was instrumental in the activity. The Spacelab pallet that carried the Canadarm2 robotic arm to the station was developed at the Marshall Space Flight Center (MSFC) in Huntsville, Alabama.

  16. International Space Station (ISS)

    NASA Image and Video Library

    2002-04-17

    This close-up view of the International Space Station (ISS), newly equipped with its new 27,000-pound S0 (S-zero) truss, was photographed by an astronaut aboard the Space Shuttle Atlantis STS-110 upon its ISS flyaround mission while pulling away from the ISS. The STS-110 mission prepared the Station for future spacewalks by installing and outfitting the 43-foot-long S0 truss and preparing the first railroad in space, the Mobile Transporter. The 27,000 pound S0 truss was the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. This central truss segment also includes a flatcar called the Mobile Transporter and rails that will become the first "space railroad," which will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. STS-110 Extravehicular Activity (EVA) marked the first use of the Station's robotic arm to maneuver spacewalkers around the station and was the first time all of a Shuttle crew's spacewalks were based out of the Station's Quest Airlock. It was also the first Shuttle to use three Block II Main Engines. The Space Shuttle Orbiter Atlantis STS-110 mission, was launched April 8, 2002 and returned to Earth April 19, 2002.

  17. International Space Station (ISS)

    NASA Image and Video Library

    2002-04-14

    STS-110 mission specialist Lee M.E. Morin carries an affixed 35 mm camera to record work which is being performed on the International Space Station (ISS). Working with astronaut Jerry L. Ross (out of frame), the duo completed the structural attachment of the S0 (s-zero) truss, mating two large tripod legs of the 13 1/2 ton structure to the station's main laboratory during a 7-hour, 30-minute space walk. The STS-110 mission prepared the Station for future space walks by installing and outfitting the 43-foot-long S0 truss and preparing the Mobile Transporter. The S0 Truss was the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. This central truss segment also includes a flatcar called the Mobile Transporter and rails that will become the first "space railroad," which will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. Milestones of the S-110 mission included the first time the ISS robotic arm was used to maneuver space walkers around the Station and marked the first time all space walks were based out of the Station's Quest Airlock. It was also the first Shuttle to use three Block II Main Engines. The Space Shuttle Orbiter Atlantis, STS-110 mission, was launched April 8, 2002 and returned to Earth April 19, 2002.

  18. International Space Station (ISS)

    NASA Image and Video Library

    2002-04-17

    This close-up view of the International Space Station (ISS), newly equipped with its new 27,000-pound S0 (S-zero) truss, was photographed by an astronaut aboard the Space Shuttle Atlantis STS-110 during its ISS flyaround mission while pulling away from the ISS. The STS-110 mission prepared the Station for future spacewalks by installing and outfitting the 43-foot-long S0 truss and preparing the first railroad in space, the Mobile Transporter. The 27,000 pound S0 truss was the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. This central truss segment also includes a flatcar called the Mobile Transporter and rails that will become the first "space railroad," which will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. STS-110 Extravehicular Activity (EVA) marked the first use of the Station's robotic arm to maneuver spacewalkers around the Station and was the first time all of a shuttle crew's spacewalks were based out of the Station's Quest Airlock. It was also the first Shuttle to use three Block II Main Engines. The Space Shuttle Orbiter Atlantis STS-110 mission, was launched April 8, 2002 and returned to Earth April 19, 2002.

  19. International Space Station (ISS)

    NASA Image and Video Library

    2002-04-17

    This close-up view of the International Space Station (ISS), newly equipped with its new 27,000 pound S0 (S-zero) truss, was photographed by an astronaut aboard the Space Shuttle Atlantis STS-110 during its ISS fly-around mission while pulling away from the ISS. The STS-110 mission prepared the Station for future spacewalks by installing and outfitting the 43-foot-long S0 truss and preparing the first railroad in space, the Mobile Transporter. The 27,000 pound S0 truss was the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. This central truss segment also includes a flatcar called the Mobile Transporter and rails that will become the first "space railroad," which will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. STS-110 Extravehicular Activity (EVA) marked the first use of the Station's robotic arm to manuever spacewalkers around the Station and was the first time all of a shuttle crew's spacewalks were based out of the Station's Quest Airlock. It was also the first Shuttle to use three Block II Main Engines. The Space Shuttle Orbiter Atlantis STS-110 mission, was launched April 8, 2002 and returned to Earth April 19, 2002.

  20. International Space Station (ISS)

    NASA Image and Video Library

    2002-04-17

    This close-up view of the International Space Station (ISS), newly equipped with its new 27,000- pound S0 (S-zero) truss, was photographed by an astronaut aboard the Space Shuttle Atlantis STS-110 mission following its undocking from the ISS. The STS-110 mission prepared the Station for future spacewalks by installing and outfitting the 43-foot-long S0 truss and preparing the first railroad in space, the Mobile Transporter. The 27,000 pound S0 truss was the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. This central truss segment also includes a flatcar called the Mobile Transporter and rails that will become the first "space railroad," which will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. STS-110 Extravehicular Activity (EVA) marked the first use of the Station's robotic arm to maneuver spacewalkers around the Station and was the first time all of a shuttle crew's spacewalks were based out of the Station's Quest Airlock. It was also the first Shuttle to use three Block II Main Engines. The Space Shuttle Orbiter Atlantis STS-110 mission, was launched April 8, 2002 and returned to Earth April 19, 2002.