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Sample records for aleph delphi l3

  1. Aleph

    SciTech Connect

    2014-08-07

    Aleph is a PIC/DSMC (particle-in-cell/direct simulation Monte Carlo) software package for the simulation of low temperature plasmas. Aleph is intended to be a production quality code capable of handling complex 3D geometries. Unstructured triangular (2D) or tetrahedral (3D) meshes are used to represent simulation domains. Aleph runs either in serial on a single processor or desktop machine, or can be run in parallel using the MPI message-passing library, to enable faster performance on large problems. Aleph employs dynamic load balancing to efficiently harness thousands of processors on high performance computers and enable simulations of up to millions of mesh elements and billions of particles. Multiple decompositions of the same mesh are used: one for the particles, and one for the field solves. Electrostatic fields are computed using an unstructured mesh finite element method (FEM), and the resulting linear systems are solved using solvers from the Trilinos package (http://trilinos.org/).

  2. Aleph

    2014-08-07

    Aleph is a PIC/DSMC (particle-in-cell/direct simulation Monte Carlo) software package for the simulation of low temperature plasmas. Aleph is intended to be a production quality code capable of handling complex 3D geometries. Unstructured triangular (2D) or tetrahedral (3D) meshes are used to represent simulation domains. Aleph runs either in serial on a single processor or desktop machine, or can be run in parallel using the MPI message-passing library, to enable faster performance on large problems.more » Aleph employs dynamic load balancing to efficiently harness thousands of processors on high performance computers and enable simulations of up to millions of mesh elements and billions of particles. Multiple decompositions of the same mesh are used: one for the particles, and one for the field solves. Electrostatic fields are computed using an unstructured mesh finite element method (FEM), and the resulting linear systems are solved using solvers from the Trilinos package (http://trilinos.org/).« less

  3. Aleph Field Solver Challenge Problem Results Summary.

    SciTech Connect

    Hooper, Russell; Moore, Stan Gerald

    2015-01-01

    Aleph models continuum electrostatic and steady and transient thermal fields using a finite-element method. Much work has gone into expanding the core solver capability to support enriched mod- eling consisting of multiple interacting fields, special boundary conditions and two-way interfacial coupling with particles modeled using Aleph's complementary particle-in-cell capability. This report provides quantitative evidence for correct implementation of Aleph's field solver via order- of-convergence assessments on a collection of problems of increasing complexity. It is intended to provide Aleph with a pedigree and to establish a basis for confidence in results for more challeng- ing problems important to Sandia's mission that Aleph was specifically designed to address.

  4. The data acquisition system for ALEPH

    SciTech Connect

    Videau, I.

    1985-08-01

    The ALEPH Collaboration is formed by 27 institutes from nine countries plus CERN and counts about 300 physicists and engineers. Its spokesman is Jack Steinberger (CERN). The ALEPH Detector is being built by the collaboration now, in order to operate at LEP beginning of 1989. LEP is the Large Electron Positron Collider built at CERN. Its initial energy will be of 90GeV (Phase I) and its nominal luminosity 10/sup 32/cm/sup -1/s/sup -1/. It is foreseen to increase the energy of the machine up to about 200 GeV during Phase II.

  5. Boltzmann-Electron Model in Aleph.

    SciTech Connect

    Hughes, Thomas Patrick; Hooper, Russell

    2014-11-01

    We apply the Boltzmann-electron model in the electrostatic, particle-in-cell, finite- element code Aleph to a plasma sheath. By assuming a Boltzmann energy distribution for the electrons, the model eliminates the need to resolve the electron plasma fre- quency, and avoids the numerical "grid instability" that can cause unphysical heating of electrons. This allows much larger timesteps to be used than with kinetic electrons. Ions are treated with the standard PIC algorithm. The Boltzmann-electron model re- quires solution of a nonlinear Poisson equation, for which we use an iterative Newton solver (NOX) from the Trilinos Project. Results for the spatial variation of density and voltage in the plasma sheath agree well with an analytic model

  6. ALEPH2 - A general purpose Monte Carlo depletion code

    SciTech Connect

    Stankovskiy, A.; Van Den Eynde, G.; Baeten, P.; Trakas, C.; Demy, P. M.; Villatte, L.

    2012-07-01

    The Monte-Carlo burn-up code ALEPH is being developed at SCK-CEN since 2004. A previous version of the code implemented the coupling between the Monte Carlo transport (any version of MCNP or MCNPX) and the ' deterministic' depletion code ORIGEN-2.2 but had important deficiencies in nuclear data treatment and limitations inherent to ORIGEN-2.2. A new version of the code, ALEPH2, has several unique features making it outstanding among other depletion codes. The most important feature is full data consistency between steady-state Monte Carlo and time-dependent depletion calculations. The last generation general-purpose nuclear data libraries (JEFF-3.1.1, ENDF/B-VII and JENDL-4) are fully implemented, including special purpose activation, spontaneous fission, fission product yield and radioactive decay data. The built-in depletion algorithm allows to eliminate the uncertainties associated with obtaining the time-dependent nuclide concentrations. A predictor-corrector mechanism, calculation of nuclear heating, calculation of decay heat, decay neutron sources are available as well. The validation of the code on the results of REBUS experimental program has been performed. The ALEPH2 has shown better agreement with measured data than other depletion codes. (authors)

  7. Implications of final L3 measurement of {sigma}{sub tot}({gamma}{gamma}{yields}bb)

    SciTech Connect

    Chyla, Jiri

    2006-02-01

    The excess of data on the total cross section of bb production in {gamma}{gamma} collisions over QCD predictions, observed by L3, OPAL and DELPHI Collaborations at LEP2, has so far defied explanation. The recent final analysis of L3 data has brought important new information concerning the dependence of the observed excess on the {gamma}{gamma} collisions energy W{sub {gamma}}{sub {gamma}}. The implications of this dependence are discussed.

  8. The L3 radiation monitor

    NASA Astrophysics Data System (ADS)

    Ahlen, S.; Goldstein, J.; Marin, A.; Xu, J.; Zhou, B.; Capell, M.; Wu, S.

    1996-02-01

    A radiation monitoring system for the L3 experiment at the Large Electron Positron (LEP) collider is described. This system was installed in the L3 detector in April 1993. It provides information on the instantaneous and integrated radiation dose in the vicinity of the L3 silicon microvertex detector and time expansion chamber, and since April 1994 it has also provided trigger signals for the LEP beam dump in the case of large instantaneous dose rates in the L3 central tracking region.

  9. A search for GMSB sleptons with lifetime at ALEPH

    NASA Astrophysics Data System (ADS)

    Jones, Luke

    2001-10-01

    A search for slepton production via the decay of pair-produced neutralinos has been performed under the assumption that the sleptons have observable lifetime in the detector before each decays to a lepton and a gravitino. Sleptons, neutralinos and gravitinos are particles predicted by the theory of supersymmetry, and are the supersymmetric partners of the Standard Model leptons, neutral bosons and of the graviton respectively. The search was performed in 628 inverse picobarns of data taken by the ALEPH detector at LEP centre-of-mass energies from 189 to 208 GeV. It was motivated by general predictions of Gauge-Mediated Supersymmetry Breaking (GMSB) models in which the lightest supersymmetric particle is always the gravitino. No evidence of the process was found. Model-independent cross-section limits are quoted as a function of neutralino mass, slepton mass and slepton lifetime in the case that the neutralino branching ratios to each slepton are equal at one third (the so-called slepton co-NLSP scenario, where NLSP stands for `Next-to-Lightest Supersymmetric Particle') and in the case that the neutralino decays exclusively to the stau (the stau-NLSP scenario). Excluded regions in the neutralino-stau mass plane are shown for four gravitino masses under model-specific assumptions.

  10. Determination of the QCD coupling from ALEPH τ decay data

    NASA Astrophysics Data System (ADS)

    Pich, Antonio; Rodríguez-Sánchez, Antonio

    2016-08-01

    We present a comprehensive study of the determination of the strong coupling from τ decay, using the most recent release of the experimental ALEPH data. We critically review all theoretical strategies used in previous works and put forward various novel approaches which allow one to study complementary aspects of the problem. We investigate the advantages and disadvantages of the different methods, trying to uncover their potential hidden weaknesses and test the stability of the obtained results under slight variations of the assumed inputs. We perform several determinations, using different methodologies, and find a very consistent set of results. All determinations are in excellent agreement, and allow us to extract a very reliable value for αs(mτ2). The main uncertainty originates in the pure perturbative error from unknown higher orders. Taking into account the systematic differences between the results obtained with the contour-improved perturbation theory and fixed-order perturbation theory prescriptions, we find αs(nf=3 )(mτ2)=0.328 ±0.013 which implies αs(nf=5 )(MZ2)=0.1197 ±0.0015 .

  11. Muon-pair production by atmospheric muons in CosmoALEPH.

    PubMed

    Maciuc, F; Grupen, C; Hashim, N-O; Luitz, S; Mailov, A; Müller, A-S; Putzer, A; Sander, H-G; Schmeling, S; Schmelling, M; Tcaciuc, R; Wachsmuth, H; Ziegler, Th; Zuber, K

    2006-01-20

    Data from a dedicated cosmic ray run of the ALEPH detector were used in a study of muon trident production, i.e., muon pairs produced by muons. Here the overburden and the calorimeters are the target materials while the ALEPH time projection chamber provides the momentum measurements. A theoretical estimate of the muon trident cross section is obtained by developing a Monte Carlo simulation for muon propagation in the overburden and the detector. Two muon trident candidates were found to match the expected theoretical pattern. The observed production rate implies that the nuclear form factor cannot be neglected for muon tridents.

  12. Process to process communication over Fastbus in the data acquisition system of the ALEPH TPC

    SciTech Connect

    Lusiani, A. . Division PPE Scuola Normale Superiore, Pisa )

    1994-02-01

    The data acquisition system of the ALEPH TPC includes a VAX/VMS computer cluster and 36 intelligent Fastbus modules (ALEPH TPPS) running the OS9 multitasking real-time operating system. Dedicated software has been written in order to reliably exchange information over Fastbus between the VAX/VMS cluster and the 36 TPPs to initialize and co-ordinate the microprocessors, and to monitor and debug their operation. The functionality and the performance of this software will be presented together with an overview of the application that rely on it.

  13. The NASA L3 Study

    NASA Technical Reports Server (NTRS)

    Stebbins, Robin

    2016-01-01

    The Astrophysics Implementation Plan calls for a minority role in L3, planned for launch in 2034. L3 The third large mission in ESAs Cosmic Visions 2015-2025 Programme NASA and ESA have been discussing a collaboration for 2 years Gravitational Observatory Advisory Team (GOAT) ESA study evaluating and recommend scientific performance tradeoffs, detection technologies, technology development activities, data analysis capabilities, schedule and cost US representatives: Guido Mueller, Mark Kasevich, Bill Klipstein, RTS Started in October 2014, concluding with a final report in late Marchor early April 2016. ESA solicited interest from ESA Member States in November 2015 NASA is continuing technology development support. ESA is restarting technology development activities.

  14. Multiple Non-Roman Scripts in ALEPH--Israel's Research Library Network.

    ERIC Educational Resources Information Center

    Lazinger, Susan S.; Levi, Judith

    1996-01-01

    Describes software solutions in the recent efforts of ALEPH, Israel's research library network, to create an online catalog system that could support the Roman, Hebrew, Arabic, and Cyrillic alphabets. The result is a multiscript, bidirectional system that uses soft fonts. (BEW)

  15. L3 Interactive Data Language

    2006-09-05

    The L3 system is a computational steering environment for image processing and scientific computing. It consists of an interactive graphical language and interface. Its purpose is to help advanced users in controlling their computational software and assist in the management of data accumulated during numerical experiments. L3 provides a combination of features not found in other environments; these are: - textual and graphical construction of programs - persistence of programs and associated data - directmore » mapping between the scripts, the parameters, and the produced data - implicit hierarchial data organization - full programmability, including conditionals and functions - incremental execution of programs The software includes the l3 language and the graphical environment. The language is a single-assignment functional language; the implementation consists of lexer, parser, interpreter, storage handler, and editing support, The graphical environment is an event-driven nested list viewer/editor providing graphical elements corresponding to the language. These elements are both the represenation of a users program and active interfaces to the values computed by that program.« less

  16. Observation of an excess in the search for the Standard Model Higgs boson at ALEPH

    NASA Astrophysics Data System (ADS)

    ALEPH Collaboration; Barate, R.; De Bonis, I.; Decamp, D.; Ghez, P.; Goy, C.; Jezequel, S.; Lees, J.-P.; Martin, F.; Merle, E.; Minard, M.-N.; Pietrzyk, B.; Bravo, S.; Casado, M. P.; Chmeissani, M.; Crespo, J. M.; Fernandez, E.; Fernandez-Bosman, M.; Garrido, Ll.; Graugés, E.; Lopez, J.; Martinez, M.; Merino, G.; Miquel, R.; Mir, Ll. M.; Pacheco, A.; Paneque, D.; Ruiz, H.; Colaleo, A.; Creanza, D.; De Filippis, N.; de Palma, M.; Iaselli, G.; Maggi, G.; Maggi, M.; Nuzzo, S.; Ranieri, A.; Raso, G.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Tricomi, A.; Zito, G.; Huang, X.; Lin, J.; Ouyang, Q.; Wang, T.; Xie, Y.; Xu, R.; Xue, S.; Zhang, J.; Zhang, L.; Zhao, W.; Abbaneo, D.; Azzurri, P.; Barklow, T.; Boix, G.; Buchmüller, O.; Cattaneo, M.; Cerutti, F.; Clerbaux, B.; Dissertori, G.; Drevermann, H.; Forty, R. W.; Frank, M.; Gianotti, F.; Greening, T. C.; Hansen, J. B.; Harvey, J.; Hutchcroft, D. E.; Janot, P.; Jost, B.; Kado, M.; Lemaitre, V.; Maley, P.; Mato, P.; Minten, A.; Moutoussi, A.; Ranjard, F.; Rolandi, L.; Schlatter, D.; Schmitt, M.; Schneider, O.; Spagnolo, P.; Tejessy, W.; Teubert, F.; Tournefier, E.; Valassi, A.; Ward, J. J.; Wright, A. E.; Ajaltouni, Z.; Badaud, F.; Dessagne, S.; Falvard, A.; Fayolle, D.; Gay, P.; Henrard, P.; Jousset, J.; Michel, B.; Monteil, S.; Montret, J.-C.; Pallin, D.; Pascolo, J. M.; Perret, P.; Podlyski, F.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Nilsson, B. S.; Wäänänen, A.; Daskalakis, G.; Kyriakis, A.; Markou, C.; Simopoulou, E.; Vayaki, A.; Blondel, A.; Brient, J.-C.; Machefert, F.; Rougé, A.; Swynghedauw, M.; Tanaka, R.; Videau, H.; Focardi, E.; Parrini, G.; Zachariadou, K.; Antonelli, A.; Antonelli, M.; Bencivenni, G.; Bologna, G.; Bossi, F.; Campana, P.; Capon, G.; Chiarella, V.; Laurelli, P.; Mannocchi, G.; Murtas, F.; Murtas, G. P.; Passalacqua, L.; Pepe-Altarelli, M.; Chalmers, M.; Halley, A. W.; Kennedy, J.; Lynch, J. G.; Negus, P.; O'Shea, V.; Raeven, B.; Smith, D.; Teixeira-Dias, P.; Thompson, A. S.; Cavanaugh, R.; Dhamotharan, S.; Geweniger, C.; Hanke, P.; Hepp, V.; Kluge, E. E.; Leibenguth, G.; Putzer, A.; Tittel, K.; Werner, S.; Wunsch, M.; Beuselinck, R.; Binnie, D. M.; Cameron, W.; Davies, G.; Dornan, P. J.; Girone, M.; Marinelli, N.; Nowell, J.; Przysiezniak, H.; Sedgbeer, J. K.; Thompson, J. C.; Thomson, E.; White, R.; Ghete, V. M.; Girtler, P.; Kneringer, E.; Kuhn, D.; Rudolph, G.; Bouhova-Thacker, E.; Bowdery, C. K.; Clarke, D. P.; Ellis, G.; Finch, A. J.; Foster, F.; Hughes, G.; Jones, R. W. L.; Pearson, M. R.; Robertson, N. A.; Smizanska, M.; Giehl, I.; Hölldorfer, F.; Jakobs, K.; Kleinknecht, K.; Kröcker, M.; Müller, A.-S.; Nürnberger, H.-A.; Quast, G.; Renk, B.; Rohne, E.; Sander, H.-G.; Schmeling, S.; Wachsmuth, H.; Zeitnitz, C.; Ziegler, T.; Bonissent, A.; Carr, J.; Coyle, P.; Curtil, C.; Ealet, A.; Fouchez, D.; Leroy, O.; Kachelhoffer, T.; Payre, P.; Rousseau, D.; Tilquin, A.; Aleppo, M.; Gilardoni, S.; Ragusa, F.; David, A.; Dietl, H.; Ganis, G.; Heister, A.; Hüttmann, K.; Lütjens, G.; Mannert, C.; Männer, W.; Moser, H.-G.; Schael, S.; Settles, R.; Stenzel, H.; Wolf, G.; Boucrot, J.; Callot, O.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, Ph.; Jacholkowska, A.; Serin, L.; Veillet, J.-J.; Videau, I.; de Vivie de Régie, J.-B.; Yuan, C.; Zerwas, D.; Bagliesi, G.; Boccali, T.; Calderini, G.; Ciulli, V.; Foà, L.; Giammanco, A.; Giassi, A.; Ligabue, F.; Messineo, A.; Palla, F.; Rizzo, G.; Sanguinetti, G.; Sciabà, A.; Sguazzoni, G.; Steinberger, J.; Tenchini, R.; Venturi, A.; Verdini, P. G.; Blair, G. A.; Coles, J.; Cowan, G.; Green, M. G.; Jones, L. T.; Medcalf, T.; Strong, J. A.; Clifft, R. W.; Edgecock, T. R.; Norton, P. R.; Tomalin, I. R.; Bloch-Devaux, B.; Boumediene, D.; Colas, P.; Fabbro, B.; Lançon, E.; Lemaire, M.-C.; Locci, E.; Perez, P.; Rander, J.; Renardy, J.-F.; Rosowsky, A.; Seager, P.; Trabelsi, A.; Tuchming, B.; Vallage, B.; Konstantinidis, N.; Loomis, C.; Litke, A. M.; Taylor, G.; Booth, C. N.; Cartwright, S.; Combley, F.; Hodgson, P. N.; Lehto, M.; Thompson, L. F.; Affholderbach, K.; Böhrer, A.; Brandt, S.; Grupen, C.; Hess, J.; Misiejuk, A.; Prange, G.; Sieler, U.; Borean, C.; Giannini, G.; Gobbo, B.; He, H.; Putz, J.; Rothberg, J.; Wasserbaech, S.; Armstrong, S. R.; Cranmer, K.; Elmer, P.; Ferguson, D. P. S.; Gao, Y.; González, S.; Hayes, O. J.; Hu, H.; Jin, S.; Kile, J.; McNamara, P. A.; Nielsen, J.; Orejudos, W.; Pan, Y. B.; Saadi, Y.; Scott, I. J.; Shao, N.; von Wimmersperg-Toeller, J. H.; Walsh, J.; Wiedenmann, W.; Wu, J.; Wu, S. L.; Wu, X.; Zobernig, G.

    2000-12-01

    A search has been performed for the Standard Model Higgs boson in the data sample collected with the ALEPH detector at LEP, at centre-of-mass energies up to 209GeV. An excess of /3σ beyond the background expectation is found, consistent with the production of the Higgs boson with a mass near 114GeV/c2. Much of this excess is seen in the four-jet analyses, where three high purity events are selected.

  17. Delphi: An Overview, An Application, Some Lessons.

    ERIC Educational Resources Information Center

    Moore, Carl M.; Coke, James G.

    This paper discusses Delphi-a method of utilizing individuals' knowledge, judgment, and opinions to address complex questions and applies the method to a community planning project in Stow, Ohio. There are four phases of any Delphi: (1) exploring the subject under discussion, with each individual contributing pertinent information, (2) reaching an…

  18. The Delphi Method for Graduate Research

    ERIC Educational Resources Information Center

    Skulmoski, Gregory J.; Hartman, Francis T.; Krahn, Jennifer

    2007-01-01

    The Delphi method is an attractive method for graduate students completing masters and PhD level research. It is a flexible research technique that has been successfully used in our program at the University of Calgary to explore new concepts within and outside of the information systems body of knowledge. The Delphi method is an iterative process…

  19. Terminating Sequential Delphi Survey Data Collection

    ERIC Educational Resources Information Center

    Kalaian, Sema A.; Kasim, Rafa M.

    2012-01-01

    The Delphi survey technique is an iterative mail or electronic (e-mail or web-based) survey method used to obtain agreement or consensus among a group of experts in a specific field on a particular issue through a well-designed and systematic multiple sequential rounds of survey administrations. Each of the multiple rounds of the Delphi survey…

  20. Use of software engineering techniques in the design of the ALEPH data acquisition system

    NASA Astrophysics Data System (ADS)

    Charity, T.; McClatchey, R.; Harvey, J.

    1987-08-01

    The SASD methodology is being used to provide a rigorous design framework for various components of the ALEPH data acquisition system. The Entity-Relationship data model is used to describe the layout and configuration of the control and acquisition systems and detector components. State Transition Diagrams are used to specify control applications such as run control and resource management and Data Flow Diagrams assist in decomposing software tasks and defining interfaces between processes. These techniques encourage rigorous software design leading to enhanced functionality and reliability. Improved documentation and communication ensures continuity over the system life-cycle and simplifies project management.

  1. The aleph pictorial electromagnetic calorimeter - A high granularity gaseous calorimeter operated in a high magnetic field

    NASA Astrophysics Data System (ADS)

    Videau, Henri

    1984-09-01

    We outline briefly the general structure of the Aleph detector, to place in context conceptually and physically the electromagnetic calorimeter. The calorimeter is then described, emphasizing the read-out mechanical and electronic structure, which allows adequate granularity; three layers of towers 3×3 cm 2, approximately 210 000 pieces of analog information. We discuss the basic properties of such apparatus with the results of tests performed on a prototype. We emphasize the peculiarities of operating such a wire gas calorimeter in a strong magnetic field parallel to the wires.

  2. Alchemy of the Oracle: The Delphi Technique.

    ERIC Educational Resources Information Center

    Wilhelm, William J.

    2001-01-01

    Discusses the origins and foundations of the Delphi technique. Outlines procedures for using it in research to obtain the insights of experts. Addresses limitations of the technique. (Contains 44 references.) (SK)

  3. Development and validation of ALEPH2 Monte Carlo burn-up code

    SciTech Connect

    Van Den Eynde, G.; Stankovskiy, A.; Fiorito, L.; Broustaut, M.

    2013-07-01

    The ALEPH2 Monte Carlo depletion code has two principal features that make it a flexible and powerful tool for reactor analysis. First of all, its comprehensive nuclear data library ensures the consistency between steady-state Monte Carlo and deterministic depletion modules. It covers neutron and proton induced reactions, neutron and proton fission product yields, spontaneous fission product yields, radioactive decay data and total recoverable energies per fission. Secondly, ALEPH2 uses an advanced numerical solver for the first order ordinary differential equations describing the isotope balances, namely a Radau IIA implicit Runge-Kutta method. The versatility of the code allows using it for time behavior simulation of various systems ranging from single pin model to full-scale reactor model. The code is extensively used for the neutronics design of the MYRRHA research fast spectrum facility which will operate in both critical and sub-critical modes. The code has been validated on the decay heat data from JOYO experimental fast reactor. (authors)

  4. αs analyses from hadronic tau decays with OPAL and ALEPH data

    NASA Astrophysics Data System (ADS)

    Boito, Diogo; Golterman, Maarten; Maltman, Kim; Peris, Santiago

    2016-07-01

    Recently, we extracted the strong coupling, αs(mτ2), from the revised ALEPH data for non-strange hadronic tau decays. Our analysis is based on a method previously used for the determination of the strong coupling from OPAL data. In our strategy, we employ different moments of the spectral functions both with and without pinching, including duality violations, in order to obtain fully self-consistent analyses that do not rely on untested assumptions (such as the smallness of higher dimension contributions in the operation product expansion (OPE)). Here we discuss the αs values obtained from the ALEPH and the OPAL data, the robustness of the analysis, as well as non-perturbative contributions from DVs and the OPE. We show that, although the αs determination is sound, non-perturbative effects limit the accuracy with which one can extract the strong coupling from tau decay data. Finally, we discuss the compatibility of the data sets and the possibility of a combined analysis.

  5. 75 FR 16513 - Delphi Packard Electrical/Electronic Architecture, a Subsidiary of Delphi Corporation, Including...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... was published in the Federal Register on January 25, 2010 (75 FR 3930). At the request of the State... Employment and Training Administration Delphi Packard Electrical/Electronic Architecture, a Subsidiary of..., applicable to workers of Delphi Packard Electrical/Electronic Architecture, a subsidiary of...

  6. College Decisions Made By the Delphi Method.

    ERIC Educational Resources Information Center

    Young, Wanda Ena

    This study reviews literature in which decisions were made using the Delphi method according to a decision model of Deising. This method is used to determine priorities in decision making. Examples are given of areas of study in which the evaluation criteria were social, technical, economic, legal, and political. (JD)

  7. The Stammering Information Programme: A Delphi Study

    ERIC Educational Resources Information Center

    Berquez, Ali E.; Cook, Frances M.; Millard, Sharon K.; Jarvis, Effie

    2011-01-01

    Purpose: To find out what information children, parents and education staff feel would be important to know to support a child who stutters in the educational environment, in order to develop appropriate resources. Method: A Delphi study was carried out to seek the opinions of experts about the information to include. A structured six stage…

  8. The L3 silicon microvertex detector

    NASA Astrophysics Data System (ADS)

    Acciarri, M.; Adam, A.; Adriani, O.; Ahlen, S.; Alcaraz, J.; Ambrosi, G.; Babucci, E.; Baksay, L.; Baschirotto, A.; Battiston, R.; Baur, W.; Bay, A.; Bencze, Gy. L.; Bertucci, B.; Biasini, M.; Bilei, G. M.; Bobbink, G. J.; Boissevain, J. G.; Bosetti, M.; Brooks, M. L.; Burger, W. J.; Busenitz, J.; Camps, C.; Caria, M.; Castellini, G.; Castello, R.; Checcuccl, B.; Chen, A.; Coan, T. E.; Commichau, V.; DiBitonto, D.; Ding, J.; Duinker, P.; Djambazov, L.; Easo, S.; Extermann, P.; Fiandrini, E.; Gabbanini, A.; Goldstein, J.; Gougas, A.; Hangarter, K.; Hauviller, C.; Herve, A.; Hofer, M.; Hofer, T.; Hou, S.; Josa, M. I.; Kapustinsky, J. S.; Kim, D.; Kinnison, W. W.; Kirst, H.; Kornis, J.; Krastev, V. R.; Ladron, P.; Landi, G.; Lebeau, M.; Lecomte, P.; Lee, D. M.; Leiste, R.; Lejeune, E.; Lin, W. T.; Lohmann, W.; Marin, A.; Massetti, R.; Mills, G. B.; Nowak, H.; Okle, M.; Passaleva, G.; Paul, T.; Pauluzzi, M.; Pensotti, S.; Perrin, E.; Produit, N.; Rancoita, P. G.; Rattaggi, M.; Richeux, J.-P.; Santocchia, A.; Siedling, R.; Sachwitz, M.; Schmitz, P.; Schöneich, B.; Servoli, L.; Subham, K.; Susinno, G. F.; Terza, G.; Tesi, M.; Thompson, T.; Tonisch, F.; Toth, J.; Trowitzsch, G.; Viertel, G.; Tuchscherer, H.; Vogt, H.; Wang, S.; Waldmeier, S.; Weill, R.; Xu, J.; Yeh, S. C.; Zhou, B.; Zilizi, G.

    1994-12-01

    The design and construction of the silicon strip microvertex detector (SMD) of the L3 experiment at LEP are described. We present the sensors, readout electronics, data acquisition system, mechanical assembly and support, displacement monitoring systems and radiation monitoring system of the recently installed double-sided, double-layered SMD. This detector utilizes novel and sophisticated techniques for its readout.

  9. Recent LEP2 results on searches for new phenomena

    SciTech Connect

    Pan Yibin

    1998-05-29

    Recent results of searches for supersymmetric particles, Higgs bosons, and other new phenomena at LEP2 are summarized. These results are based on data and analyses from the four LEP experiments: ALEPH, DELPHI, L3, and OPAL. The data were collected during the summer and fall of 1996 with center-of-mass energies of 161 and 172 GeV.

  10. Internet-Based Delphi Research: Case Based Discussion

    NASA Astrophysics Data System (ADS)

    Cole, Zachary Douglas; Donohoe, Holly M.; Stellefson, Michael L.

    2013-03-01

    The interactive capacity of the Internet offers benefits that are intimately linked with contemporary research innovation in the natural resource and environmental studies domains. However, e-research methodologies, such as the e-Delphi technique, have yet to undergo critical review. This study advances methodological discourse on the e-Delphi technique by critically assessing an e-Delphi case study. The analysis suggests that the benefits of using e-Delphi are noteworthy but the authors acknowledge that researchers are likely to face challenges that could potentially compromise research validity and reliability. To ensure that these issues are sufficiently considered when planning and designing an e-Delphi, important facets of the technique are discussed and recommendations are offered to help the environmental researcher avoid potential pitfalls associated with coordinating e-Delphi research.

  11. Internet-Based Delphi Research: Case Based Discussion

    PubMed Central

    Donohoe, Holly M.; Stellefson, Michael L.

    2013-01-01

    The interactive capacity of the Internet offers benefits that are intimately linked with contemporary research innovation in the natural resource and environmental studies domains. However, e-research methodologies, such as the e-Delphi technique, have yet to undergo critical review. This study advances methodological discourse on the e-Delphi technique by critically assessing an e-Delphi case study. The analysis suggests that the benefits of using e-Delphi are noteworthy but the authors acknowledge that researchers are likely to face challenges that could potentially compromise research validity and reliability. To ensure that these issues are sufficiently considered when planning and designing an e-Delphi, important facets of the technique are discussed and recommendations are offered to help the environmental researcher avoid potential pitfalls associated with coordinating e-Delphi research. PMID:23288149

  12. Internet-based Delphi research: case based discussion.

    PubMed

    Cole, Zachary Douglas; Donohoe, Holly M; Stellefson, Michael L

    2013-03-01

    The interactive capacity of the Internet offers benefits that are intimately linked with contemporary research innovation in the natural resource and environmental studies domains. However, e-research methodologies, such as the e-Delphi technique, have yet to undergo critical review. This study advances methodological discourse on the e-Delphi technique by critically assessing an e-Delphi case study. The analysis suggests that the benefits of using e-Delphi are noteworthy but the authors acknowledge that researchers are likely to face challenges that could potentially compromise research validity and reliability. To ensure that these issues are sufficiently considered when planning and designing an e-Delphi, important facets of the technique are discussed and recommendations are offered to help the environmental researcher avoid potential pitfalls associated with coordinating e-Delphi research.

  13. A Delphi forecast of technology in education

    NASA Technical Reports Server (NTRS)

    Robinson, B. E.

    1973-01-01

    The results are reported of a Delphi forecast of the utilization and social impacts of large-scale educational telecommunications technology. The focus is on both forecasting methodology and educational technology. The various methods of forecasting used by futurists are analyzed from the perspective of the most appropriate method for a prognosticator of educational technology, and review and critical analysis are presented of previous forecasts and studies. Graphic responses, summarized comments, and a scenario of education in 1990 are presented.

  14. A monolithic analog multiplexor for the ALEPH electromagnetic calorimeter adapted to operation of LEP at high luminosity

    SciTech Connect

    Veillet, J.J.; Richer, J.P.; Chase, R.L.; Ardelen, J. )

    1992-08-01

    The hybrid analog multiplexor, currently in use on the ALEPH experiment at LEP, is a variation of a previously described system which was designed for 4-bunch operation of LEP, corresponding to a beam crossing period of 22.5 [mu]s, and is not compatible with the proposed 36-bunch (2.5 [mu]s period) operation. The new system described in this paper will operate with a beam crossing period only slightly longer than the trigger delay time and at counting rates greater than 10[sup 4]/s per channel without sacrificing the ease of calibration of the previous system.

  15. Continuing Education for Women. Planning Delphi. Final Report.

    ERIC Educational Resources Information Center

    White, Julia A.; Jillson, Irene A.

    As part of a 2-year study to plan, develop, and offer relevant continuing education programs for women in Pensacola, a Delphi study was conducted to determine the educational needs and priorities of different types of women living in Pensacola. The Delphi method was selected because it is considered an effective way of eliciting the opinions of a…

  16. Career and Technical Education at a Crossroads: A Delphi Study

    ERIC Educational Resources Information Center

    Cutright, Michael W.

    2011-01-01

    Career and technical education in the United States has reached a critical juncture. A three round Delphi method was used to determine a consensus on the future events of career and technical education to better inform educational decision makers. Forty-one individual experts in the field were invited to serve as panelists for the Delphi study and…

  17. Personal Learning Environments and University Teacher Roles Explored Using Delphi

    ERIC Educational Resources Information Center

    Shaikh, Zaffar Ahmed; Khoja, Shakeel Ahmed

    2014-01-01

    This paper presents the results of research using an online Delphi method, which aimed to explore university teacher roles and readiness for learner-centred pedagogy, driven by personal learning environments (PLEs). Using a modified Policy Delphi technique, a group of researchers worked with 34 international experts who are university teachers by…

  18. Using the Delphi Technique to Support Curriculum Development

    ERIC Educational Resources Information Center

    Sitlington, Helen Barbara; Coetzer, Alan John

    2015-01-01

    Purpose: The purpose of this paper is to present an analysis of the use of the Delphi technique to support curriculum development with a view to enhancing existing literature on use of the technique for renewal of business course curricula. Design/methodology/approach: The authors outline the Delphi process for obtaining consensus amongst a…

  19. Using the Delphi Technique in Educational Technology Research

    ERIC Educational Resources Information Center

    Nworie, John

    2011-01-01

    As educational technology practitioners and researchers engage in research in the field, a wide array of research methodologies are available to them. One such methodology is the Delphi Technique. Use of the Delphi Technique offers many benefits, including the ability to obtain expert opinion, build consensus, determine the suitability of the…

  20. The Gravitational Universe - ESA's L3 mission

    NASA Astrophysics Data System (ADS)

    Mueller, Guido; Ando, Masaki; Binetruy, Pierre; Bouyer, Philippe; Cacciapuoti, Luigi; Cruise, Mike; Favata, Fabio; Gehler, Martin; Genzel, Reinhard; Jennrich, Oliver; Kasevich, Mark; Klipstein, Bill; Perryman, Michael; Safa, Frederic; Schutz, Bernard; Stebbins, Robin; Vitale, Stefano

    2015-04-01

    Following the advice of ESA's Senior Survey Committee (SSC) the Science Programme Committee (SPC) decided in November 2013 to select the science theme ``The Gravitational Universe'' for their L3 mission. The Director of Science and Robotic Exploration (D/SRE) has established a Gravitational Observatory Advisory Team (GOAT) to advise on the scientific and technological approaches for a gravitational wave observatory with a planned launch date in 2034. Our team is comprised of scientists from Europe and the US as well as scientists and engineers from ESA and observers from NASA and JAXA. We meet about every ten weeks, evaluate the technical readiness of all necessary technologies, study the science impact of different mission designs, and will advise ESA on the required future technology development. We will report on our progress and plans forward to a future space-based gravitational-wave observatory. For JAXA.

  1. The Effects of L2 Experience on L3 Perception

    ERIC Educational Resources Information Center

    Onishi, Hiromi

    2016-01-01

    This study examines the influence of experience with a second language (L2) on the perception of phonological contrasts in a third language (L3). This study contributes to L3 phonology by examining the influence of L2 phonological perception abilities on the perception of an L3 at the beginner level. Participants were native speakers of Korean…

  2. Charged TGC from 1999 DELPHI Data

    NASA Astrophysics Data System (ADS)

    Fassouliotis, Dimitris

    Measurements of the trilinear gauge boson couplings WWγ and WWZ are presented from data taken by DELPHI in 1999 at an energy ranging from 192 to 202 GeV. Values are extracted with respect to Δ gZ1 and Δ κγ, the differences of the WWZ charge coupling and of the WWγ dipole coupling from their Standard Model values, and λγ, the WWγ quadrupole coupling. The study uses data from the final states jjl ν, jjjj, l X, jjX and γ X, where j represents a quark jet, l an identified lepton and X missing four-momentum. The observations are consistent with the Standard Model predictions.

  3. Performance of the HPC calorimeter in DELPHI

    SciTech Connect

    Chan, A.; Crawley, H.B.; Edsall, D.M. |

    1995-08-01

    The performance of the High-density Projection Chamber (HPC), the barrel electromagnetic calorimeter of the DELPHI experiment, is described. The detector adopts the time projection technique in order to obtain exceptionally fine spatial granularity in the three coordinates ({approximately}2{times}20 mrad{sup 2} in {theta}{times}{phi} with nine samplings along the shower axes), using a limited number of readout channels (18,432). Among the various topics concerning the HPC construction and operation, major emphasis is given to the aspects related to the calibration in energy of the calorimeter, based mainly on the analysis of the detector response to {sup 83m}Kr decays, and to the treatment of aging in the readout proportional counters.

  4. Investigating adaptive grieving styles: a Delphi study.

    PubMed

    Doughty, Elizabeth A

    2009-05-01

    There has been an evolution in the understanding of the nature of grief since S. Freud's initial work, Mourning and Melancholia (1917/1953). Mental health practitioners and researchers have established new models to aid in the conceptualization and treatment of grief issues. The purpose of this study was to examine the opinions of experts in the field of grief regarding elements of a new model of adult bereavement, Martin and Doka's (2000) adaptive grieving styles, using the Delphi Method to identify points of consensus. A survey of 20 experts in the field of thanatology reached consensus on 21 items in which the panelists addressed the uniqueness of the griever, recognized there are multiple factors that influence the grieving process (i.e., culture, personality, and gender), that most bereaved individuals use both cognitive and affective strategies in adapting to bereavement, and that bereaved individuals experience both internal and external pressures to grieve in particular ways.

  5. Evaluation of Nine Consensus Indices in Delphi Foresight Research and Their Dependency on Delphi Survey Characteristics: A Simulation Study and Debate on Delphi Design and Interpretation

    PubMed Central

    Birko, Stanislav; Dove, Edward S.; Özdemir, Vural

    2015-01-01

    The extent of consensus (or the lack thereof) among experts in emerging fields of innovation can serve as antecedents of scientific, societal, investor and stakeholder synergy or conflict. Naturally, how we measure consensus is of great importance to science and technology strategic foresight. The Delphi methodology is a widely used anonymous survey technique to evaluate consensus among a panel of experts. Surprisingly, there is little guidance on how indices of consensus can be influenced by parameters of the Delphi survey itself. We simulated a classic three-round Delphi survey building on the concept of clustered consensus/dissensus. We evaluated three study characteristics that are pertinent for design of Delphi foresight research: (1) the number of survey questions, (2) the sample size, and (3) the extent to which experts conform to group opinion (the Group Conformity Index) in a Delphi study. Their impacts on the following nine Delphi consensus indices were then examined in 1000 simulations: Clustered Mode, Clustered Pairwise Agreement, Conger’s Kappa, De Moivre index, Extremities Version of the Clustered Pairwise Agreement, Fleiss’ Kappa, Mode, the Interquartile Range and Pairwise Agreement. The dependency of a consensus index on the Delphi survey characteristics was expressed from 0.000 (no dependency) to 1.000 (full dependency). The number of questions (range: 6 to 40) in a survey did not have a notable impact whereby the dependency values remained below 0.030. The variation in sample size (range: 6 to 50) displayed the top three impacts for the Interquartile Range, the Clustered Mode and the Mode (dependency = 0.396, 0.130, 0.116, respectively). The Group Conformity Index, a construct akin to measuring stubbornness/flexibility of experts’ opinions, greatly impacted all nine Delphi consensus indices (dependency = 0.200 to 0.504), except the Extremity CPWA and the Interquartile Range that were impacted only beyond the first decimal point (dependency

  6. DELPHI: An introduction to output layout and data content

    SciTech Connect

    Smith, C.F.

    1994-08-16

    DELPHI was the data summary and interpretation code used by gas diagnostics personnel during the period from 1968 through 1986. It was written by Floyd Momyer, and went through several revisions during its period of use. Described here is the final version, which provided the most extensive set of summary tables. Earlier versions of the code lacked some of the capabilities of the final version, but what they did include was of substantially the same format. DELPHI was run against most available input decks in the mid 1980s. Microfiche and hardcopy output were generated. Both now reside in our archives. These reruns used modified input decks, which may not have had the proper {open_quotes}trigger{close_quotes} to instruct DELPHI to output some tables. These tables could, therefore be missing from a printout even though the necessary data was present. Also, modifications to DELPHI did, in some instances, eliminate DELPHIs` capability to correctly output some of the earlier optional tables. This monologue is intended to compliment the archived printout, and to provide enough insight so that someone unfamiliar with the techniques of Gas Diagnostics can retrieve the results at some future date. DELPHI last ran on the CDC-7600 machines, and was not converted to run on the Crays when the CDC-7600`s were decommissioned. DELPHI accepted data from various analytical systems, set up data summary tables, and combined preshot tracer and detector data with these results to calculate the total production of measured species and the indicated fission yields and detector conversions.

  7. SOLID STATE ENERGY CONVERSION ALLIANCE DELPHI SOFC

    SciTech Connect

    Steven Shaffer; Sean Kelly; Subhasish Mukerjee; David Schumann; H. Skip Mieney

    2003-06-09

    The objective of Phase I under this project is to develop a 5 kW Solid Oxide Fuel Cell power system for a range of fuels and applications. During Phase I, the following will be accomplished: Develop and demonstrate technology transfer efforts on a 5 kW stationary distributed power generation system that incorporates steam reforming of natural gas with piped-in water (Demonstration System A); and Initiate development of a 5 kW system for later mass-market automotive auxiliary power unit application, which will incorporate Catalytic Partial Oxidation (CPO) reforming of gasoline, with anode exhaust gas injected into an ultra-lean burn internal combustion engine. This technical progress report covers work performed by Delphi from July through December 2002 under Department of Energy Cooperative Agreement DE-FC-02NT41246 for the 5 kW mass-market automotive (gasoline) auxiliary power unit. This report highlights technical results of the work performed under the following tasks for the automotive 5 kW system: Task 1--System Design and Integration; Task 2--Solid Oxide Fuel Cell Stack Developments; Task 3--Reformer Developments; Task 4--Development of Balance of Plant (BOP) Components; Task 5--Manufacturing Development (Privately Funded); Task 6--System Fabrication; and Task 7--System Testing.

  8. Solid State Energy Conversion Alliance Delphi SOFC

    SciTech Connect

    Steven Shaffer; Sean Kelly; Larry Chick; Subhasish Mukerjee; David Schumann

    2003-05-20

    The objective of Phase I under this project is to develop a 5 kW SOFC power system for a range of fuels and applications. During Phase I, the following will be accomplished: 1. Develop and demonstrate technology transfer efforts on a 5 kW stationary distributed power generation system that incorporates steam reforming of natural gas with piped-in water (Demonstration System A). 2. Initiate development of a 5 kW system for later mass-market automotive auxiliary power unit application, which will incorporate catalytic partial oxidation (CPO) reforming of gasoline, with anode exhaust gas injected into an ultra-lean burn internal combustion engine. This topical report covers work performed by Delphi Automotive Systems from January through June 2002 under DOE Cooperative Agreement DE-FC-02NT41246 for the 5 kW mass-market automotive (gasoline) auxiliary power unit. This report highlights technical results of the work performed under the following tasks for the automotive 5 kW system: 1. System Design and Integration 2. SOFC Stack Development 3. Reformer Development The next anticipated Technical Progress Report will be submitted January 30, 2003 and will include tasks contained within the cooperative agreement including development work on the Demonstration System A, if available.

  9. Application of L3 technology to wavefront sensing

    NASA Astrophysics Data System (ADS)

    Tulloch, Simon M.

    2004-10-01

    The new L3 Technology CCDs from E2V combine sub-electron read noise with high pixel rates. This makes them ideal candidates for wavefront sensing. ING's NAOMI adaptive optics instrument is currently limited by the readout noise of its wavefront sensor CCDs. Upgrading to L3 detectors has the potential to give a large increase in performance; simulations suggest a 2 magnitude improvement to the guide star limit. At ING we have explored the behaviour of various L3 devices in applications ranging from fast photometry, fast spectroscopy through to wavefront sensing. The investigations have been done using our own cryogenic cameras containing L3 devices coupled to an SDSU controller. An integral Peltier packaged CCD60 has also been purchased specifically for the WFS upgrade. This paper describes the progress we have made to date on the L3 wavefront sensor upgrade and our future plans for its use with a Rayleigh laser beacon.

  10. B and D spectroscopy at LEP

    SciTech Connect

    Muheim, Franz

    1999-02-17

    Results from the four LEP experiments ALEPH, DELPHI, L3, and OPAL on the spectroscopy of B and charmed mesons are presented. The predictions of Heavy Quark Effective Theory (HQET) for the masses and the widths of excited L=1 B mesons are supported by a new measurement from L3. A few B{sub c}{sup +} candidate events have masses consistent with the recent CDF observation and the predictions. New results on D** production and B{yields}D**l{nu} are also presented. The evidence for a D*{sup '} meson reported recently by DELPHI is not supported by OPAL and CLEO.

  11. NASA's Preparations for ESA's L3 Gravitational Wave Mission

    NASA Astrophysics Data System (ADS)

    Stebbins, Robin

    2016-03-01

    The European Space Agency (ESA) selected gravitational-wave astrophysics as the science theme for its third large mission opportunity, known as `L3,' under its Cosmic Vision Programme. NASA is seeking a role as an international partner in L3. NASA is: (1) participating in ESA's early mission activities, (2) developing potential US technology contributions, (3) participating in ESA's LISA Pathfinder mission, (4) and conducting a study of how NASA might participate. This talk will survey the status of these activities.

  12. AFP-L3 — EDRN Public Portal

    Cancer.gov

    AFP-L3, also known as lectin-bound AFP, is an isoform of AFP, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. The L3 isoform is specific to malignant tumors and its detected presence may serve to identify patients who could benefit from monitoring for the development of HCC in high risk populations (i.e. chronic hepatitis, liver cirrhosis).

  13. Identifying Threshold Concepts for Information Literacy: A Delphi Study

    ERIC Educational Resources Information Center

    Townsend, Lori; Hofer, Amy R.; Hanick, Silvia Lin; Brunetti, Korey

    2016-01-01

    This study used the Delphi method to engage expert practitioners on the topic of threshold concepts--core ideas and processes in a discipline that students need to grasp in order to progress in their learning, but that are often unspoken or unrecognized by expert practitioners--for information literacy. A panel of experts considered two questions:…

  14. Future Directions in Deinstitutionalization and Education: A Delphi Investigation.

    ERIC Educational Resources Information Center

    Putnam, Joanne W.; Bruininks, Robert H.

    1986-01-01

    A total of 33 special education leaders presented forecasts, through a Delphi survey procedure, for the deinstitutionalization of and the residential and education services for the handicapped. It was predicted that the deinstitutionalization movement will not lose its momentum and that community based residential services will become increasingly…

  15. A Delphi Study: The Characteristics of Democratic Schools

    ERIC Educational Resources Information Center

    Korkmaz, H. Eylem; Erden, Münire

    2014-01-01

    The authors aim to identify characteristics of democratic schools. The Delphi technique used in this study is based on attaining a consensus among a group of experts over 3 rounds with 22 experts from 9 countries participating in the first round. By the end of the third round, 339 items referring to democratic school characteristics were…

  16. Electronic-Imen-Delphi (EID): An Online Conferencing Procedure.

    ERIC Educational Resources Information Center

    Passig, David; Sharbat, Aviva

    2000-01-01

    Examines the efficiency of the Imen-Delphi (ID) technique as an electronic procedure for conferencing that helps participants clarify their opinions and expectations regarding preferable and possible futures. Describes an electronic version of the original ID procedure and tested its efficiency among a group of experts on virtual reality and…

  17. Predicting Future Trends in Adult Fitness Using the Delphi Approach.

    ERIC Educational Resources Information Center

    Murray, William F.; Jarman, Boyd O.

    1987-01-01

    This study examines the future of adult fitness from the perspective of experts. The Delphi Technique was used as a measurement tool. Findings revealed that the experts most relied on increased awareness of health and fitness among the elderly as a significant predictor variable. (Author/CB)

  18. Research Areas in Distance Education: A Delphi Study

    ERIC Educational Resources Information Center

    Zawacki-Richter, Olaf

    2009-01-01

    This study had three purposes: Firstly, to develop a categorization of research areas in distance education; secondly, to identify the most important research areas in distance education; and thirdly, to identify the most neglected research areas in distance education. Based on a literature review and a Delphi study, three broad levels or…

  19. Secondary Engineering Competencies: A Delphi Study of Engineering Faculty

    ERIC Educational Resources Information Center

    Harris, Kara S.; Rogers, George E.

    2008-01-01

    The central purpose of this study was to expand upon previous research in relation to competencies that are desired by university engineering faculty in their incoming freshman. This study used a Delphi technique as noted by Paige, Dugger, and Wolansky (1996) and Wicklein (1993) to identify and analyze what secondary education competencies should…

  20. Issues Facing Urban Agriscience Teachers: A Delphi Study

    ERIC Educational Resources Information Center

    Warner, Wendy J.; Washburn, Shannon G.

    2009-01-01

    This national study used the Delphi technique to identify the issues facing urban agriscience teachers. The first round of the study used a questionnaire with one open-ended question to generate responses from the expert panel. In the second round, respondents were asked to rate their level of agreement with 72 issues identified in round one using…

  1. A Delphi Study of Research Priorities in Tech Prep.

    ERIC Educational Resources Information Center

    Farmer, Edgar I.

    1998-01-01

    A Delphi panel of 37 tech-prep subject matter experts identified a national research agenda for tech prep. Highest priorities were as follows: institutionalization of tech prep into the higher education system, instruction based on cognitive science research, and nontraditional teaching methods. (SK)

  2. Expert Consensus on Characteristics of Wisdom: A Delphi Method Study

    ERIC Educational Resources Information Center

    Jeste, Dilip V.; Ardelt, Monika; Blazer, Dan; Kraemer, Helena C.; Vaillant, George; Meeks, Thomas W.

    2010-01-01

    Purpose: Wisdom has received increasing attention in empirical research in recent years, especially in gerontology and psychology, but consistent definitions of wisdom remain elusive. We sought to better characterize this concept via an expert consensus panel using a 2-phase Delphi method. Design and Methods: A survey questionnaire comprised 53…

  3. Health Professionals' Perceptions of Sexual Assault Management: A Delphi Study

    ERIC Educational Resources Information Center

    Jancey, Jonine; Meuleners, Lynn; Phillips, Maureen

    2011-01-01

    Objective: To explore health professionals' perceptions of sexual assault management practices and identify issues related to these practices across Western Australia (WA). Design: A two-round electronic Delphi study was undertaken with health professionals (medical doctors, registered nurses, social workers and managers). Setting: Healthcare…

  4. Establishing a Research Agenda for Art Therapy: A Delphi Study

    ERIC Educational Resources Information Center

    Kaiser, Donna; Deaver, Sarah

    2013-01-01

    Art therapy in the United States is a young profession that would benefit from an identified research agenda to marshal resources more effectively to address gaps in the knowledge base. This article describes a Delphi study of U.S. art therapy researchers who were surveyed on research priorities for the profession. The research panelists were…

  5. Reinforcement of Science Learning through Local Culture: A Delphi Study

    ERIC Educational Resources Information Center

    Nuangchalerm, Prasart

    2008-01-01

    This study aims to explore the ways to reinforce science learning through local culture by using Delphi technique. Twenty four participants in various fields of study were selected. The result of study provides a framework for reinforcement of science learning through local culture on the theme life and environment. (Contains 1 table.)

  6. A Delphi Study to Update CTE Teacher Competencies

    ERIC Educational Resources Information Center

    Manley, R. Adam; Zinser, Richard

    2012-01-01

    Purpose: The purpose of this project was to create a contemporary taxonomy of Career and Technical Education (CTE) teacher competencies in order to evaluate and improve CTE teacher education. Design/methodology/approach: This study utilized a modified Delphi technique with a large sample of CTE experts--teachers, administrators, and…

  7. Identifying Quality Indicators of SAE and FFA: A Delphi Approach

    ERIC Educational Resources Information Center

    Jenkins, Charles Cordell, III; Kitchel, Tracy

    2009-01-01

    The purpose of this study was to determine quality indicators for SAE and FFA according to 36 experts across the United States. This is a part of a larger study looking at all components of the traditional three-circle model. The study utilized the Delphi technique to garner expert opinion about quality indicators in Agricultural Education. For…

  8. Open Educational Resources: A Delphi Study of Instructional Design Quality

    ERIC Educational Resources Information Center

    Emerson, Marnice K.

    2013-01-01

    The purpose of this modified Delphi research study was to investigate instructional designers' beliefs about the instructional strategies and activities to be included in a universal framework for designing quality, self-directed, multimedia, open educational resources (OERs). With the rapid growth of availability and use of OERs by a widely…

  9. Teacher Beliefs About Educational Software: A Delphi Study

    ERIC Educational Resources Information Center

    Williams, Diana L.; Boone, Randall; Kingsley, Karla V.

    2004-01-01

    A Delphi method was used to determine the extent to which current educational software was meeting the needs of teachers; as well as what changes needed to occur in educational software to make it more effective. Five overarching themes emerged: (a) instructional design issues, (b) curriculum, (c) materials, (d) cost, and (e) meeting specific…

  10. High School Agricultural Communications Competencies: A National Delphi Study.

    ERIC Educational Resources Information Center

    Akers, Cindy L.; Vaughn, Paul R.; Haygood, Jacqui D.

    2003-01-01

    In a three-round Delphi study, agriscience faculty (n=75, 43, 41) refined and categorized competencies in 11 topic areas for a high school agricultural communications course. Appropriate topics and competencies for beginning and intermediate levels were identified. (Contains 12 references.) (SK)

  11. Motivation and Discipline in the Vocational Classroom: A Delphi Approach.

    ERIC Educational Resources Information Center

    Ward, William Gary

    One hundred and forty-four strategies and techniques on motivation and discipline in the vocational classroom are listed in the document. The items were generated and subsequently ranked by 130 vocational educators from the 50 States using the Delphi Technique. The total ranking of all items is presented in table 1. The items, grouped into common…

  12. Future Directions for Business Education: A Delphi Study

    ERIC Educational Resources Information Center

    Kesten, Cyril A.; Lambrecht, Judith J.

    2010-01-01

    Purpose: The purpose of this study was to synthesize perceptions from the field about current issues and to propose future directions for the field of business education. Method: A modified three-stage Delphi study was carried out with business educators who attended national conferences and/or belonged to national professional organizations.…

  13. The Delphi: Education and Assessment in Institutional Goal Setting.

    ERIC Educational Resources Information Center

    Fazio, Linda S.

    1985-01-01

    The use of delphi techniques in a school of osteopathic medicine is described to assess and change faculty perceptions of institutional goals and needs such as curriculum orientation, campus design and location, faculty personnel policy, teaching and instructional evaluation, student characteristics and admission policies, and administrative…

  14. How to use the nominal group and Delphi techniques.

    PubMed

    McMillan, Sara S; King, Michelle; Tully, Mary P

    2016-06-01

    Introduction The Nominal Group Technique (NGT) and Delphi Technique are consensus methods used in research that is directed at problem-solving, idea-generation, or determining priorities. While consensus methods are commonly used in health services literature, few studies in pharmacy practice use these methods. This paper provides an overview of the NGT and Delphi technique, including the steps involved and the types of research questions best suited to each method, with examples from the pharmacy literature. Methodology The NGT entails face-to-face discussion in small groups, and provides a prompt result for researchers. The classic NGT involves four key stages: silent generation, round robin, clarification and voting (ranking). Variations have occurred in relation to generating ideas, and how 'consensus' is obtained from participants. The Delphi technique uses a multistage self-completed questionnaire with individual feedback, to determine consensus from a larger group of 'experts.' Questionnaires have been mailed, or more recently, e-mailed to participants. When to use The NGT has been used to explore consumer and stakeholder views, while the Delphi technique is commonly used to develop guidelines with health professionals. Method choice is influenced by various factors, including the research question, the perception of consensus required, and associated practicalities such as time and geography. Limitations The NGT requires participants to personally attend a meeting. This may prove difficult to organise and geography may limit attendance. The Delphi technique can take weeks or months to conclude, especially if multiple rounds are required, and may be complex for lay people to complete. PMID:26846316

  15. L3 Acquisition of German Adjectival Inflection: A Generative Account

    ERIC Educational Resources Information Center

    Jaensch, Carol

    2011-01-01

    Studies testing the knowledge of syntactic properties have resulted in two potentially contrasting proposals in relation to third language acquisition (TLA); the Cumulative Enhancement Model (Flynn et al., 2004), which proposes that previously learned languages will positively affect the acquisition of a third language (L3); and the "second…

  16. Language Switches in L3 Production: Implications for a Polyglot.

    ERIC Educational Resources Information Center

    Williams, Sarah; Hammarberg, Bjorn

    1998-01-01

    Presents results from ongoing research about non-adapted language switches, highlighting a longitudinal study of an adult learner of third-language (L3) Swedish with first-language (L1) English and second-language (L2) German. The study is based on 844 non-adapted language switches. Researchers identified four types of switches. Results indicated…

  17. L2-Accented Speech in L3 Production

    ERIC Educational Resources Information Center

    Wrembel, Magdalena

    2010-01-01

    The paper is aimed at investigating the sources of cross-linguistic influence in the third language (L3) phonology, and, particularly, the impact of the second language (L2) on the phonological acquisition of another foreign language. The study consisted in foreign accent judgements performed by a group of expert judges who were presented with…

  18. The Impact of Analogy on L3 Reading Comprehension

    ERIC Educational Resources Information Center

    Karami, Hossein; Nodoushan, Mohammad Ali Salmani

    2014-01-01

    Little research has been conducted to investigate the effect of analogy on third language (L3, hereafter) reading comprehension though some experts believe that it has facilitating and debilitating effects on L1 and L2 respectively. This article explores the effect of analogies on reading comprehension of expository texts by students of English as…

  19. Verification of a Quality Management Theory: Using a Delphi Study

    PubMed Central

    Mosadeghrad, Ali Mohammad

    2013-01-01

    Background: A model of quality management called Strategic Collaborative Quality Management (SCQM) model was developed based on the quality management literature review, the findings of a survey on quality management assessment in healthcare organisations, semi-structured interviews with healthcare stakeholders, and a Delphi study on healthcare quality management experts. The purpose of this study was to verify the SCQM model. Methods: The proposed model was further developed using feedback from thirty quality management experts using a Delphi method. Further, a guidebook for its implementation was prepared including a road map and performance measurement. Results: The research led to the development of a context-specific model of quality management for healthcare organisations and a series of guidelines for its implementation. Conclusion: A proper model of quality management should be developed and implemented properly in healthcare organisations to achieve business excellence. PMID:24596883

  20. Forensics ergonomics in Spain. Research priorities by the Delphi technique.

    PubMed

    Llaneza Alvarez, F J; Rosal Lopez, G; Peña Suarez, Elsa; Rodriguez Suarez, J

    2012-01-01

    Among the many fields of application of Ergonomics, this research deals with the services offered to Justice from the expertise recognized by the Law on prevention of occupational risks within the framework of the Law of Civil Procedure: Ergonomics forensic also called Legal Ergonomics. In Spain there are experiences since 1995 and an important development and this paper is to investigate the actions required for a more widespread use in trials. Consensus methods such as the Delphi survey technique are being employed to help enhance effective decision-making in the future development of Ergonomics Forensics. The Delphi survey is a group facilitation technique, which is an iterative multistage process, designed to transform opinion into group consensus. It is a flexible approach, that is used commonly within the health and social sciences, however, there is little use and practice of ergonomics as a technique to facilitate the participation of all experts involved: judges, lawyers and expert ergonomists.

  1. A randomized, controlled, blinded study of the safety, immunogenicity and batch consistency of Aleph inactivated split influenza vaccine made in China in Chinese people.

    PubMed

    Li, Shuming; Li, Li; Ai, Xing; Yang, Liqing; Bai, Yunhua; Wang, Zhaoyun; Han, Huixia; Lu, Qiang; Luo, Fengji; Zhang, Zheng; Liu, Chunyu; Xiao, Jun; Shi, Nianmin

    2014-01-01

    To evaluate the safety, immunogenicity and batch consistency of Aleph inactivated split influenza vaccine, 3308 healthy Chinese people more than 3 years old were enrolled in a randomized, controlled, blinded study and divided into four age groups: 3-10 years, 11-17 years, 18-54 years, and more than 55 years. Each age group was then randomized (2:1) to receive either influenza vaccine or control vaccine (recombinant hepatitis B) for one dose. Also each influenza vaccine group was randomized (1:1:1) to receive three different batches of influenza vaccine. Systematic and local adverse reactions for 28 days after vaccination were recorded, and influenza antibody titer was determined by hemagglutination inhibition (HI) assay at 28 days after vaccination. There were significant differences in seroconversion and seroprotection rates achieved post-immunization of three strains of influenza antibody (H1N1, H3N2, B) between experimental group and control group in all age groups (P<0.05). In addition, there were no statistically significant differences in local and systematic reaction rates after vaccination between the experimental and control group in all age groups (P>0.05), except for the systematic reaction rates in the 18-54 years and ≥ 55 years age groups (P<0.05). Thus, Aleph inactivated split influenza vaccine has good safety and immunogenicity.

  2. Identifying the features of an exercise addiction: A Delphi study.

    PubMed

    Macfarlane, Lucy; Owens, Glynn; Cruz, Borja Del Pozo

    2016-09-01

    Objectives There remains limited consensus regarding the definition and conceptual basis of exercise addiction. An understanding of the factors motivating maintenance of addictive exercise behavior is important for appropriately targeting intervention. The aims of this study were twofold: first, to establish consensus on features of an exercise addiction using Delphi methodology and second, to identify whether these features are congruous with a conceptual model of exercise addiction adapted from the Work Craving Model. Methods A three-round Delphi process explored the views of participants regarding the features of an exercise addiction. The participants were selected from sport and exercise relevant domains, including physicians, physiotherapists, coaches, trainers, and athletes. Suggestions meeting consensus were considered with regard to the proposed conceptual model. Results and discussion Sixty-three items reached consensus. There was concordance of opinion that exercising excessively is an addiction, and therefore it was appropriate to consider the suggestions in light of the addiction-based conceptual model. Statements reaching consensus were consistent with all three components of the model: learned (negative perfectionism), behavioral (obsessive-compulsive drive), and hedonic (self-worth compensation and reduction of negative affect and withdrawal). Conclusions Delphi methodology allowed consensus to be reached regarding the features of an exercise addiction, and these features were consistent with our hypothesized conceptual model of exercise addiction. This study is the first to have applied Delphi methodology to the exercise addiction field, and therefore introduces a novel approach to exercise addiction research that can be used as a template to stimulate future examination using this technique.

  3. UTC Power/Delphi SECA CBS Final Report

    SciTech Connect

    Gorman, Michael; Kerr, Rich

    2013-04-04

    The subject report summarizes the results of solid oxide fuel cell development conducted by UTC Power in conjunction with Delphi Automotive Systems under a cost-share program with from October 2008 through March of 2013. Over that period Delphi Automotive Systems developed a nearly four times larger area solid oxide fuel cell stack capable of operating on pre-reformed natural gas and simulated coal gas with durability demonstrated to 5,000 hours and projected to exceed 10,000 hours. The new stack design was scaled to 40-cell stacks with power output in excess of 6.25kW. Delphi also made significant strides in improving the manufacturability, yield and production cost of these solid oxide fuel cells over the course of the program. Concurrently, UTC Power developed a conceptual design for a 120 MW Integrated Gasification Fuel Cell (IGFC) operating on coal syngas with as high as 57% Higher Heating Value (HHV) efficiency as a measure of the feasibility of the technology. Subsequently a 400 kW on-site system preliminary design with 55% Lower Heating Value (LHV) efficiency operating on natural gas was down-selected from eighteen candidate designs. That design was used as the basis for a 25kW breadboard power plant incorporating four Delphi cell stacks that was tested on natural gas before the program was discontinued due to the sale of UTC Power in early 2013. Though the program was cut short of the endurance target of 3,000 hours, many aspects of the technology were proven including: large-area, repeatable cell manufacture, cell stack operation on simulated coal gas and natural gas and integrated power plant operation on natural gas. The potential of the technology for high efficiency stationary electric power generation is clear. Acceptable production costs, durability, and reliability in real world environments are the remaining challenges to commercialization.

  4. Study of Neutral Triple Gauge Couplings in DELPHI

    NASA Astrophysics Data System (ADS)

    Pieri, Lidia

    2002-04-01

    Neutral Triple Gauge boson Couplings ZZZ, ZZ γ and Z γ γ are studied using data collected by the DELPHI detector at LEP at energies between 189 and 208 GeV. The reactions e^+ e^- arrow Z γ, e^+ e^- arrow Z Z and e^+ e^- arrow Z γ^* are used. A summary of the main theoretical aspects of NTGC is given. A summary of the reactions used for deriving limits on these couplings is reported. Current limits are shown.

  5. Photon induced L3 vacancy alignment at tuned photon energies

    NASA Astrophysics Data System (ADS)

    Bansal, Himani; Kaur, Gurpreet; Tiwari, Manoj K.; Mittal, Raj

    2016-04-01

    Photon induced L3 X-ray measurements for Lα/Lℓ cross-section ratios in elements, 66 ⩽ Z ⩽ 83, at tuned photon energies on synchrotron Beamline-16 at Indus-2, India have been used to study the effect of Coster-Kronig (CK) transitions and photon energies on alignment of L3 vacancies. Certainty and reliability of the measurements were checked from comparison of measured Lα and Lℓ fluorescence cross-sections at E1 excitation with available theoretical/empirical/experimental values that required additional measurements for source, geometry and efficiency factor S0GɛLα/ℓ in the used set-up. Fall/rise trend of the ratios with energy for different Z's was found to resemble the off/on-set pattern of CK transitions as pointed out by Bambynek et al. and Campbell. Evaluated alignment parameter A2 values are very much within the limits, 0.05 L3 are aligned (A2 ≦ 0.2) in all the cases. The pattern of A'2 (Coster-Kronig corrected A2) variation with energy for Dy, W, Pt, Hg and Bi resembles our previously reported theoretical patterns that lends mutual support for both current measurements and earlier theoretical results.

  6. A Delphi Study on Staff Bereavement Training in the Intellectual and Developmental Disabilities Field

    ERIC Educational Resources Information Center

    Gray, Jennifer A.; Truesdale, Jesslyn

    2015-01-01

    The Delphi technique was used to obtain expert panel consensus to prioritize content areas and delivery methods for developing staff grief and bereavement curriculum training in the intellectual and developmental disabilities (IDD) field. The Delphi technique was conducted with a panel of 18 experts from formal and informal disability caregiving,…

  7. Reducing Energy Cost and Greenhouse Gas Emission in the Corporate Sector, a Delphi Study

    ERIC Educational Resources Information Center

    Kramer, Maxim L.

    2013-01-01

    The study is titled "Reducing energy cost and GreenHouse Gas emission in the corporate sector, A Delphi Study". The study applied the Delphi methodology and focused on the Green IT solutions that can help the modern corporate organizations with less than 1000 employees to decrease their energy costs and GHG emissions. The study presents…

  8. Concepts and Contexts in Engineering and Technology Education: An International and Interdisciplinary Delphi Study

    ERIC Educational Resources Information Center

    Rossouw, Ammeret; Hacker, Michael; de Vries, Marc J.

    2011-01-01

    Inspired by a similar study by Osborne et al. we have conducted a Delphi study among experts to identify key concepts to be taught in engineering and technology education and relevant and meaningful contexts through which these concepts can be taught and learnt. By submitting the outcomes of the Delphi study to a panel of experts in a two-day…

  9. DELPHI--An Information Resource in a Multivendor Multiprotocol Network Environment.

    ERIC Educational Resources Information Center

    Sedayao, Jeff; And Others

    1992-01-01

    Describes DELPHI, a networked information resource for Intel Corporation that provides a bulletin board, databases, technical memos, hazardous material handling information, and stock quotes. Topics addressed include the diverse network environments at Intel, connecting the services to these environments, experiences with DELPHI, and future plans.…

  10. Advantages and Limitations of the e-Delphi Technique: Implications for Health Education Researchers

    ERIC Educational Resources Information Center

    Donohoe, Holly; Stellefson, Michael; Tennant, Bethany

    2012-01-01

    In the last 30 years, the application of the Delphi technique has been increasing. With the recent availability and established popularity of Internet-based research tools, the Internet has been identified as a means for mitigating Delphi limitations, maximizing its advantages, and expanding the breadth of its application. The discourse on the…

  11. Delphi: Potential Uses in Educational Planning. Project Simu-School: Chicago Component.

    ERIC Educational Resources Information Center

    Skutsch, Margaret; Hall, Diana

    Delphi is a method for obtaining group judgments on factual matters for which precise information may not be available, and on values for which information is a matter of opinion. This paper discusses different applications of the Delphi method to educational planning and attempts to evaluate its potential in resolving the particular needs of the…

  12. Exploration to Identify Professional Dispositions of School Librarians: A Delphi Study

    ERIC Educational Resources Information Center

    Bush, Gail; Jones, Jami L.

    2010-01-01

    This article reports the findings of an exploratory study to identify professional dispositions of school librarians. The authors employed the Delphi method, a qualitative research method that emphasizes expert knowledge and consensus within a particular field. The Delphi panel consisted of members of the editorial boards of nationally recognized…

  13. Projecting Agricultural Education Programs for the 21st Century Using a Modified Delphi Technique.

    ERIC Educational Resources Information Center

    Iverson, Maynard J.

    A modified three-step Delphi procedure was used to conduct a series of national studies of futurists regarded by their peers as top experts in agricultural education. The primary objective was to project enrollments in agricultural education programs for the 21st century. Other study objectives were to ascertain whether the Delphi technique could…

  14. Methodological and Conceptual Issues Confronting a Cross-Country Delphi Study of Educational Program Evaluation

    ERIC Educational Resources Information Center

    Hung, Hsin-Ling; Altschuld, James W.; Lee, Yi-Fang

    2008-01-01

    Although the Delphi is widely used, research on certain methodological issues is somewhat limited. After a brief introduction to the strengths, limitations, and methodological challenges of the technique, we share our experiences (as well as problems encountered) with an electronic Delphi of educational program evaluation (EPE) in the Asia-Pacific…

  15. Effective Decision Making within the Organization: A Comparison of Regular, NGT, and Delphi Group Processes.

    ERIC Educational Resources Information Center

    Crawford, John E.; Cossitt, William B.

    Three group processes--regular face-to-face interacting groups, the nominal group technique (NGT), and Delphi procedures--were compared in terms of their ability to facilitate the quantitative and qualitative productivity of a decision making group. The results unequivocally supported the superiority of the Delphi procedures. Findings also tended…

  16. A hardware and software overview of the Delphi contiguity trigger

    SciTech Connect

    Darbo, G. ); Heck, B.W.; Wildman, J.M. )

    1991-04-01

    The contiguity processor of the Delphi detector, which is composed of 12 Fastbus modules (one for each TPC sector), is the main second-level track trigger component in the experiment. More than 3000 Mips of processing power are achieved by 4608 processing elements (PE) packed in specially designed ASIC IC's. High interconnectivity among PE's (bidimensional lattice) and a highly parallel algorithm (contiguity mask) allow a three-dimensional vertex reconstruction in less than 5{mu}s. In this paper an overview of the single instruction multiple data (SIMD) architecture, together with the programming language and the interactive debugging tools for the processor, are given.

  17. Neutron noise measurements at the Delphi subcritical assembly

    SciTech Connect

    Szieberth, M.; Klujber, G.; Kloosterman, J. L.; De Haas, D.

    2012-07-01

    The paper presents the results and evaluations of a comprehensive set of neutron noise measurements on the Delphi subcritical assembly of the Delft Univ. of Technology. The measurements investigated the effect of different source distributions (inherent spontaneous fission and {sup 252}Cf) and the position of the detectors applied (both radially and vertically). The evaluation of the measured data has been performed by the variance-to-mean ratio (VTMR, Feynman-{alpha}), the autocorrelation (ACF, Rossi-{alpha}) and the cross-correlation (CCF) methods. The values obtained for the prompt decay constant show a strong bias, which depends both on the detector position and on the source distribution. This is due to the presence of higher modes in the system. It has been observed that the {alpha} value fitted is higher when the detector is close to the boundary of the core or to the {sup 252}Cf point-source. The higher alpha-modes have also been observed by fitting functions describing two alpha-modes. The successful set of measurement also provides a good basis for further theoretical investigations including the Monte Carlo simulation of the noise measurements and the calculation of the alpha-modes in the Delphi subcritical assembly. (authors)

  18. Gadamerian philosophical hermeneutics as a useful methodological framework for the Delphi technique

    PubMed Central

    Guzys, Diana; Dickson-Swift, Virginia; Kenny, Amanda; Threlkeld, Guinever

    2015-01-01

    In this article we aim to demonstrate how Gadamerian philosophical hermeneutics may provide a sound methodological framework for researchers using the Delphi Technique (Delphi) in studies exploring health and well-being. Reporting of the use of Delphi in health and well-being research is increasing, but less attention has been given to covering its methodological underpinnings. In Delphi, a structured anonymous conversation between participants is facilitated, via an iterative survey process. Participants are specifically selected for their knowledge and experience with the topic of interest. The purpose of structuring conversation in this manner is to cultivate collective opinion and highlight areas of disagreement, using a process that minimizes the influence of group dynamics. The underlying premise is that the opinion of a collective is more useful than that of an individual. In designing our study into health literacy, Delphi aligned well with our research focus and would enable us to capture collective views. However, we were interested in the methodology that would inform our study. As researchers, we believe that methodology provides the framework and principles for a study and is integral to research integrity. In assessing the suitability of Delphi for our research purpose, we found little information about underpinning methodology. The absence of a universally recognized or consistent methodology associated with Delphi was highlighted through a scoping review we undertook to assist us in our methodological thinking. This led us to consider alternative methodologies, which might be congruent with the key principles of Delphi. We identified Gadamerian philosophical hermeneutics as a methodology that could provide a supportive framework and principles. We suggest that this methodology may be useful in health and well-being studies utilizing the Delphi method. PMID:25948132

  19. Identifying indicators through modified Delphi technique in polytechnics system

    NASA Astrophysics Data System (ADS)

    Nashir, Irdayanti Mat; Mustapha, Ramlee; Yusoff, Abdullah

    2015-02-01

    This study aims to examine how the panel has been selected as experts in assessing indicators of innovative instructional leadership (IIL) administrator in polytechnics based on 222 items were obtained through previous studies. A total of eleven people were selected as the expert panels in a study where expert selection criteria based on their background in the leadership. Experts were interviewed separately. Interviews were carried out for a half hour in their offices. The data obtained were analyzed using Atlas Ti. Overall findings indicate experts agree that a total of 188 items and 14 indicators should be maintained in this innovative instructional leadership instruments and next by using Modified Delphi Technique. The instrument will then be analyzed to obtain findings on the perception of lecturers on every administrator innovative instructional leadership in their respective polytechnics.

  20. Performance of the DELPHI small angle tile calorimeter

    SciTech Connect

    Alvsvaag, S.J.; Maeland, O.A.; Klovning, A.

    1996-06-01

    The DELPHI STIC detector is a lead-scintillator sampling calorimeter with wave length shifting optical fibers used for light collection. The main goal of the calorimeter at LEP100 is to measure the luminosity with an accuracy better than 0.1%. The detector has been in operation since the 1994 LEP run. Presented here is the performance measured during the 1994--1995 LEP runs, with the emphasis on the achieved energy and space resolution, the long-term stability and the efficiency of the detector. The new bunchtrains mode of LEP requires a rather sophisticated trigger and timing scheme which is also presented. To control the trigger efficiency and stability of the calorimeter channels, a LED-based monitoring system has been developed.

  1. Occupational health research priorities in Malaysia: a Delphi study

    PubMed Central

    Sadhra, S; Beach, J; Aw, T; Sheikh-Ahmed, K

    2001-01-01

    OBJECTIVES—As part of a consultancy project on occupational health, the Delphi method was used to identify research priorities in occupational health in Malaysia.
METHODS—Participation was sought from government ministries, industry, and professional organisations, and university departments with an interest in occupational and public health. Two rounds of questionnaires resulted in a final list of priorities, with noticeable differences between participants depending on whether they worked in industry or were from government organisations.
RESULTS—The participation rate of 71% (55 of 78) was obtained for the first questionnaire and 76% (72 of 95) for the second questionnaire. The participants identified occupational health problems for specific groups and industries as the top research priority area (ranked as top priority by 25% of participants). Ministry of Health participants placed emphasis on healthcare workers (52% ranking it as top priority), whereas those from industry identified construction and plantation workers as groups, which should be accorded the highest priority. Evaluation of research and services was given a low priority.
CONCLUSIONS—The priorities for occupational health determined with the Delphi approach showed differences between Malaysia, a developing country, and findings from similar European studies. This may be expected, as differences exist in stages of economic development, types of industries, occupational activities, and cultural attitudes to occupational health and safety. Chemical poisonings and workplace accidents were accorded a high priority. By contrast with findings from western countries, workplace psychosocial problems and musculoskeletal injuries were deemed less important. There also seemed to be greater emphasis on adopting interventions for identified problems based on experience in other countries rather than the need to evaluate local occupational health provisions.


Keywords: occupational

  2. The performance of the DELPHI hadron calorimeter at LEP

    SciTech Connect

    Ajinenko, I.; Beloous, K.; Chudoba, J. |

    1996-06-01

    The DELPHI Hadron Calorimeter was conceived more than ten years ago, as an instrument to measure the energy of hadrons and hadronic jets from e{sup +}e{sup {minus}} collisions at the CERN collider LEP. In addition it was expected to provide a certain degree of discrimination between pions and muons. The detector is a rather simple and relatively inexpensive device consisting of around 20,000 limited streamer plastic tubes, with inductive pad read-out, embedded in the iron yoke of the 1.2 T DELPHI magnet. Its depth is at minimum 6.6 nuclear interaction lengths. The electronics necessary for the pad readout was designed to have an adequate performance for a reasonable cost. This detector has proved over six years of operation to have an entirely satisfactory performance and great reliability; for example less than 1% of the streamer tubes have failed and electronic problems remain at the per mil level. During the past two years an improvement program has been under way. It has been found possible to use the streamer tubes as strips, hence giving better granularity and particle tracking, by reading out the cathode of individual tubes. The constraints on this were considerable because of the inaccessibility of the detectors in the magnet yoke. However, a cheap and feasible solution has been found. The cathode readout leads to an improved energy resolution, better {mu} identification, a better {pi}/{mu} separation and to possibilities of neutral particle separation. The simultaneous anode read-out of several planes of the endcaps of the detector will provide a fast trigger in the forward/backward direction which is an important improvement for LEP200. On the barrel the system will provide a cosmic trigger which is very useful for calibration as counting rates at LEP200 will be very low.

  3. Modified Policy-Delphi study for exploring obesity prevention priorities

    PubMed Central

    Haynes, Emily; Palermo, Claire; Reidlinger, Dianne P

    2016-01-01

    Introduction Until now, industry and government stakeholders have dominated public discourse about policy options for obesity. While consumer involvement in health service delivery and research has been embraced, methods which engage consumers in health policy development are lacking. Conflicting priorities have generated ethical concern around obesity policy. The concept of ‘intrusiveness’ has been applied to policy decisions in the UK, whereby ethical implications are considered through level of intrusiveness to choice; however, the concept has also been used to avert government regulation to address obesity. The concept of intrusiveness has not been explored from a stakeholder's perspective. The aim is to investigate the relevance of intrusiveness and autonomy to health policy development, and to explore consensus on obesity policy priorities of under-represented stakeholders. Methods and analysis The Policy-Delphi technique will be modified using the James Lind Alliance approach to collaborative priority setting. A total of 60 participants will be recruited to represent three stakeholder groups in the Australian context: consumers, public health practitioners and policymakers. A three-round online Policy-Delphi survey will be undertaken. Participants will prioritise options informed by submissions to the 2009 Australian Government Inquiry into Obesity, and rate the intrusiveness of those proposed. An additional round will use qualitative methods in a face-to-face discussion group to explore stakeholder perceptions of the intrusiveness of options. The novelty of this methodology will redress the balance by bringing the consumer voice forward to identify ethically acceptable obesity policy options. Ethics and dissemination Ethical approval was granted by the Bond University Health Research Ethics Committee. The findings will inform development of a conceptual framework for analysing and prioritising obesity policy options, which will be relevant

  4. Identifying appropriate tasks for the preregistration year: modified Delphi technique

    PubMed Central

    Stewart, Jane; O’Halloran, Catherine; Harrigan, Patrick; Spencer, John A; Barton, J Roger; Singleton, Stephen J

    1999-01-01

    Objectives To identify the tasks that should constitute the work of preregistration house officers to provide the basis for the development of a self evaluation instrument. Design Literature review and modified Delphi technique. Setting Northern Deanery within the Northern and Yorkshire office NHS executive. Subjects 67 educational supervisors of preregistration house officers. Main outcome measures Percentage of agreement by educational supervisors to tasks identified from the literature. Results Over 61% of communication items, 70% of on call patient care items, 75% of routine patient care items, 45% of practical procedure items, and over 63% of self management items achieved over 95% agreement that they should be part of the house job of preregistration house officers. Poor agreement was found for the laboratory and clinical investigations that house officers could perform with or without supervision. Conclusions The tasks of house officers were identified but issues in using this method and in devising a universally acceptable list of tasks for preregistration house officers were apparent. Key messagesMore than 100 activities were identified as potential tasks for house officers, and 11 personal abilities were identified as self management skillsThe ability of preregistration house officers to perform all of the tasks independently would be restricted by their experiences and therefore may depend on the specialty in which they workThe deliberation over what are and are not “shared tasks” was evident; some educational supervisors wanted the house officer to be capable of, but not practise, some tasks whereas others did not believe these tasks were within the remit of the house officerThe Delphi technique is a useful method for gaining the autonomous opinions of individuals from a large group of geographically distant members PMID:10417084

  5. Teacher Competencies in Health Education: Results of a Delphi Study

    PubMed Central

    Moynihan, Sharon; Paakkari, Leena; Välimaa, Raili; Jourdan, Didier; Mannix-McNamara, Patricia

    2015-01-01

    Objective The aim of this research study was to identify the core competencies for health education teachers in supporting the development of health literacy among their students. Method/Results A three round Delphi method was employed. Experts in health education were asked to identify core competencies for school health educators. Twenty six participants from the academic field were invited to participate in the study. Twenty participants completed the first round of the Delphi, while eighteen took part in round two and fifteen participated in the final round. Data were collected using an electronic questionnaire. The first round contained an open ended question in which participants were asked to name and define all the competencies they perceived were important. Thematic analysis was undertaken on these data. A list of 36 competencies was created from this round. This list was then returned to the same participants and they were asked to rate each competency on a 7 point semantic differential scale in terms of importance. The resulting data were then analysed. For the final round, participants were presented with a list of 33 competencies and were asked to rank them again, in order of importance. Conclusion Twelve core competencies emerged from the analysis and these competencies comprised of a mixture of knowledge, attitude and skills. The authors suggest that how these competencies are achieved and operationalised in the school context can be quite complex and multi-faceted. While the authors do not seek to generalise from the study they suggest that these competencies are an important input for all stakeholders, in order to question national and international teacher guidelines. In addition the competencies identified may provide a useful starting point for others to undertake deeper analysis of what it means to be an effective health educator in schools. PMID:26630180

  6. Object Pronouns in German L3 Syntax: Evidence for the L2 Status Factor

    ERIC Educational Resources Information Center

    Falk, Ylva; Bardel, Camilla

    2011-01-01

    Several studies on L3 lexicon, and recently also some on L3 syntax, have convincingly shown a qualitative difference between the acquisition of a true L2 and the subsequent acquisition of an L3. Some studies even indicate that L2 takes on a stronger role than L1 in the initial state of L3 syntax (e.g. Bardel and Falk, 2007; Rothman and Cabrelli…

  7. Informing the Age-of-Acquisition Debate: L3 as a Litmus Test

    ERIC Educational Resources Information Center

    Iverson, Michael

    2010-01-01

    Following Cabrelli et al. (What the start of L3 tells us about the end of L2: N-drop in L2 and L3 Portuguese, BUCLD, 2008), Iverson (Competing SLA hypotheses assessed: Comparing heritage and successive Spanish bilinguals of L3 Brazilian Portuguese, Mouton de Gruyter, 2009) and others, I argue that the L3 initial state is an important tool in…

  8. Three decision-making aids: brainstorming, nominal group, and Delphi technique.

    PubMed

    McMurray, A R

    1994-01-01

    The methods of brainstorming, Nominal Group Technique, and the Delphi technique can be important resources for nursing staff development educators who wish to expand their decision-making skills. Staff development educators may find opportunities to use these methods for such tasks as developing courses, setting departmental goals, and forecasting trends for planning purposes. Brainstorming, Nominal Group Technique, and the Delphi technique provide a structured format that helps increase the quantity and quality of participant responses.

  9. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  10. 26 CFR 1.401(l)-3 - Permitted disparity for defined benefit plans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....401(l)-3 Section 1.401(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.401(l)-3... employer-provided benefits under a defined benefit plan is permitted under section 401(l) and this...

  11. 26 CFR 1.7701(l)-3 - Recharacterizing financing arrangements involving fast-pay stock.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... involving fast-pay stock. 1.7701(l)-3 Section 1.7701(l)-3 Internal Revenue INTERNAL REVENUE SERVICE....7701(l)-3 Recharacterizing financing arrangements involving fast-pay stock. (a) Purpose and scope. This... is benefited stock. Example 3. Planned section 302(d) redemptions. (i) Facts. Corporation L,...

  12. L1 and L2 Distance Effects in Learning L3 Dutch

    ERIC Educational Resources Information Center

    Schepens, Job J.; der Slik, Frans; Hout, Roeland

    2016-01-01

    Many people speak more than two languages. How do languages acquired earlier affect the learnability of additional languages? We show that linguistic distances between speakers' first (L1) and second (L2) languages and their third (L3) language play a role. Larger distances from the L1 to the L3 and from the L2 to the L3 correlate with lower…

  13. TES/Aura L3 Ammonia (NH3) Daily (TL3NH3D)

    Atmospheric Science Data Center

    2015-08-28

    TES/Aura L3 Ammonia (NH3) Daily (TL3NH3D) News:  TES News ... Level:  L3 Instrument:  TES/Aura L3 Ammonia Spatial Coverage:  5.3 x 8.5 km Spatial ... Data: TES Order Tool Parameters:  Ammonia Order Data:  Reverb:   Order Data ...

  14. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  15. 26 CFR 1.401(l)-3 - Permitted disparity for defined benefit plans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....401(l)-3 Section 1.401(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY.... § 1.401(l)-3 Permitted disparity for defined benefit plans. (a) Requirements—(1) In general. Disparity... 401(l) and this section for a plan year only if the plan satisfies paragraphs (a)(2) through (a)(6)...

  16. 26 CFR 1.401(l)-3 - Permitted disparity for defined benefit plans.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....401(l)-3 Section 1.401(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY.... § 1.401(l)-3 Permitted disparity for defined benefit plans. (a) Requirements—(1) In general. Disparity... 401(l) and this section for a plan year only if the plan satisfies paragraphs (a)(2) through (a)(6)...

  17. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  18. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  19. 26 CFR 1.401(l)-3 - Permitted disparity for defined benefit plans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....401(l)-3 Section 1.401(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY.... § 1.401(l)-3 Permitted disparity for defined benefit plans. (a) Requirements—(1) In general. Disparity... 401(l) and this section for a plan year only if the plan satisfies paragraphs (a)(2) through (a)(6)...

  20. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  1. Three Unusual Chondrules in the Bovedy (L3) Chondrite

    NASA Astrophysics Data System (ADS)

    Hill, H. G. M.

    1993-07-01

    The Bovedy (L3) chondrite [1] has recently been studied petrographically using SEM and EMPA as part of a general review of the Irish meteorites. The following chondrules are notable: Chondrule 1. A covered thin-section of the Bovedy (Sprucefield) meteorite contains a very highly-strained, ellipsoidal, radiating pyroxene chondrule with a semi-major axis of 2mm. The elongation ratio, 2.6 x, is higher than values published elsewhere [2]. Chondrule 2. A slab of Bovedy (~48 cm^2) contains an exceptionally large, ellipsoidal, porphyritic olivine chondrule (semi-major axis = 1.4 cm, minor axis = 0.8 cm). This is among the largest droplet chondrule on record [2]. The chondrule is texturally identical to other PO chondrules in the meteorite. Chondrule 3. A polished thin-section, prepared from the above slab, contains an ellipsoidal-to-irregular shaped glassy chondrule (Fig. 1). SEM and EMPA confirm a composition of pyroxenitic glass (brown) with globular and elongate inclusions of silica glass (colorless). Representative EMPA of the brown glass (in wt%) is: SiO2 57.49, Al2O3 0.93, Cr2O3 0.38, FeO 14.22, MnO 0.63, MgO 23.32, CaO 2.69, Na2O 1.03 (no other elements detected). This can be recast as a pyroxene with formula Ca(sub)0.10 Na(sub)0.07 Fe(sub)0.43Mg(sub)1.26Al(sub)0.04 Cr(sub)0.01Mn(sub)0.02Si(sub)2.08O(sub)6. The composition corresponds closely with that reported by [3] for a silica pyroxenite clast from the same meteorite. It suggests that the chondrule was derived by rapid melting of the material represented by the clast, which has been interpreted as an igneous fractionate formed in a planetary environment. References: [1] Graham A. L. et al. (1976) GCA, 40, 529-535. [2] Grossman J. N. et al. (1988) In Meteorites and the Early Solar System (J. F. Kerridge and M. S. Matthews, eds.), 619-659, Univ. Arizona. [3] Ruzicka A. and Boynton W. V. (1992) Meteoritics, 27, 283. Fig. 1, which appears here in the hard copy, shows a photograph of chondrule 3 photographed in

  2. DELirium Prediction Based on Hospital Information (Delphi) in General Surgery Patients.

    PubMed

    Kim, Min Young; Park, Ui Jun; Kim, Hyoung Tae; Cho, Won Hyun

    2016-03-01

    To develop a simple and accurate delirium prediction score that would allow identification of individuals with a high probability of postoperative delirium on the basis of preoperative and immediate postoperative data.Postoperative delirium, although transient, is associated with adverse outcomes after surgery. However, there has been no appropriate tool to predict postoperative delirium.This was a prospective observational single-center study, which consisted of the development of the DELirium Prediction based on Hospital Information (Delphi) score (n = 561) and its validation (n = 533). We collected potential risk factors for postoperative delirium, which were identified by conducting a comprehensive review of the literatures.Age, low physical activity, hearing impairment, heavy alcoholism, history of prior delirium, intensive care unit (ICU) admission, emergency surgery, open surgery, and increased preoperative C-reactive protein were identified as independent predictors of postoperative delirium. The Delphi score was generated using logistic regression coefficients. The maximum Delphi score was 15 and the optimal cut-off point identified with the Youden index was 6.5. Generated area under the (AUC) of the receiver operating characteristic (ROC) curve was 0.911 (95% CI: 0.88-0.94). In the validation study, the calculated AUC of the ROC curve based on the Delphi score was 0.938 (95% Cl: 0.91-0.97). We divided the validation cohort into the low-risk group (Delphi score 0-6) and high-risk group (7-15). Sensitivity of Delphi score was 80.8% and specificity 92.5%.Our proposed Delphi score could help health-care provider to predict the development of delirium and make possible targeted intervention to prevent delirium in high-risk surgery patients.

  3. Experience of Delphi technique in the process of establishing consensus on core competencies

    PubMed Central

    Raghav, Pankaja Ravi; Kumar, Dewesh; Bhardwaj, Pankaj

    2016-01-01

    Introduction: The Department of Community Medicine and Family Medicine (CMFM) has been started as a new model for imparting the components of family medicine and delivering health-care services at primary and secondary levels in all six newly established All India Institute of Medical Sciences (AIIMS), but there is no competency-based curriculum for it. The paper aims to share the experience of Delphi method in the process of developing consensus on core competencies of the new model of CMFM in AIIMS for undergraduate medical students in India. Methods: The study adopted different approaches and methods, but Delphi was the most critical method used in this research. In Delphi, the experts were contacted by e-mail and their feedback on the same was analyzed. Results: Two rounds of Delphi were conducted in which 150 participants were contacted in Delphi-I but only 46 responded. In Delphi-II, 26 participants responded whose responses were finally considered for analysis. Three of the core competencies namely clinician, primary-care physician, and professionalism were agreed by all the participants, and the least agreement was observed in the competencies of epidemiologist and medical teacher. The experts having more experience were less consistent as responses were changed from agree to disagree in more than 15% of participants and 6% changed from disagree to agree. Conclusion: Within the given constraints, the final list of competencies and skills for the discipline of CMFM compiled after the Delphi process will provide a useful insight into the development of competency-based curriculum of the subject. PMID:27563586

  4. SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes

    PubMed Central

    Stielow, Christina; Stielow, Bastian; Finkernagel, Florian; Scharfe, Maren; Jarek, Michael; Suske, Guntram

    2014-01-01

    Lethal(3) malignant brain tumour like 2 (L3MBTL2) is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. Here, we show that L3MBTL2 is modified by SUMO2/3 at lysine residues 675 and 700 close to the C-terminus. SUMOylation of L3MBTL2 neither affected its repressive activity in reporter gene assays nor it’s binding to histone tails in vitro. In order to analyse whether SUMOylation affects binding of L3MBTL2 to chromatin, we performed ChIP-Seq analysis with chromatin of wild-type HEK293 cells and with chromatin of HEK293 cells stably expressing either FLAG-tagged SUMOylation-competent or SUMOylation-defective L3MBTL2. Wild-type FLAG-L3MBTL2 and the SUMOylation-defective FLAG-L3MBTL2 K675/700R mutant essentially occupied the same sites as endogenous L3MBTL2 suggesting that SUMOylation of L3MBTL2 does not affect chromatin binding. However, a subset of L3MBTL2-target genes, particularly those with low L3MBTL2 occupancy including pro-inflammatory genes, was de-repressed in cells expressing the FLAG-L3MBTL2 K675/700R mutant. Finally, we provide evidence that SUMOylation of L3MBTL2 facilitates repression of these PRC1.6-target genes by balancing the local H2Aub1 levels established by the ubiquitinating enzyme RING2 and the de-ubiquitinating PR–DUB complex. PMID:24369422

  5. SOLID STATE ENERGY CONVERSION ALLIANCE DELPHI SOLID OXIDE FUEL CELL

    SciTech Connect

    Steven Shaffer; Sean Kelly; Subhasish Mukerjee; David Schumann; Gail Geiger; Kevin Keegan; John Noetzel; Larry Chick

    2003-12-08

    The objective of Phase I under this project is to develop a 5 kW Solid Oxide Fuel Cell power system for a range of fuels and applications. During Phase I, the following will be accomplished: Develop and demonstrate technology transfer efforts on a 5 kW stationary distributed power generation system that incorporates steam reforming of natural gas with the option of piped-in water (Demonstration System A). Initiate development of a 5 kW system for later mass-market automotive auxiliary power unit application, which will incorporate Catalytic Partial Oxidation (CPO) reforming of gasoline, with anode exhaust gas injected into an ultra-lean burn internal combustion engine. This technical progress report covers work performed by Delphi from January 1, 2003 to June 30, 2003, under Department of Energy Cooperative Agreement DE-FC-02NT41246. This report highlights technical results of the work performed under the following tasks: Task 1 System Design and Integration; Task 2 Solid Oxide Fuel Cell Stack Developments; Task 3 Reformer Developments; Task 4 Development of Balance of Plant (BOP) Components; Task 5 Manufacturing Development (Privately Funded); Task 6 System Fabrication; Task 7 System Testing; Task 8 Program Management; and Task 9 Stack Testing with Coal-Based Reformate.

  6. Recovery in Psychosis: A Delphi Study With Experts by Experience

    PubMed Central

    Law, Heather; Morrison, Anthony P.

    2014-01-01

    This study aimed to establish consensus about the meaning of recovery among individuals with experience of psychosis. A Delphi approach was utilized to allow a large sample of service users to be anonymously consulted about their views on recovery. Service users were invited to take part in a 3-stage consultation process. A total of 381 participants gave their views on recovery in the main stage of this study, with 100 of these taking part in the final review stage. The final list of statements about recovery included 94 items, which were rated as essential or important by >80% of respondents. These statements covered items which define recovery, factors which help recovery, factors which hinder recovery, and factors which show that someone is recovering. As far as we are aware, it is the first study to identify areas of consensus in relation to definitions of recovery from a service user perspective, which are typically reported to be an idiosyncratic process. Implications and recommendations for clinical practice and future research are discussed. PMID:24727194

  7. Recovery in psychosis: a Delphi study with experts by experience.

    PubMed

    Law, Heather; Morrison, Anthony P

    2014-11-01

    This study aimed to establish consensus about the meaning of recovery among individuals with experience of psychosis. A Delphi approach was utilized to allow a large sample of service users to be anonymously consulted about their views on recovery. Service users were invited to take part in a 3-stage consultation process. A total of 381 participants gave their views on recovery in the main stage of this study, with 100 of these taking part in the final review stage. The final list of statements about recovery included 94 items, which were rated as essential or important by >80% of respondents. These statements covered items which define recovery, factors which help recovery, factors which hinder recovery, and factors which show that someone is recovering. As far as we are aware, it is the first study to identify areas of consensus in relation to definitions of recovery from a service user perspective, which are typically reported to be an idiosyncratic process. Implications and recommendations for clinical practice and future research are discussed.

  8. A combined ANP-delphi approach to evaluate sustainable tourism

    SciTech Connect

    Garcia-Melon, Monica

    2012-04-15

    The evaluation of sustainable tourism strategies promoted by National Parks (NP) related stakeholders is a key concern for NP managers. To help them in their strategic evaluation procedures, in this paper we propose a methodology based on the Analytic Network Process and a Delphi-type judgment-ensuring procedure. The approach aims at involving stakeholders in a participatory and consensus-building process. The methodology was applied to Los Roques NP in Venezuela. The problem included three sustainable tourism strategies defined by the stakeholders: eco-efficient resorts, eco-friendly leisure activities and ecological transportation systems. Representatives of eight stakeholders participated in the methodology. 13 sustainability criteria were selected. Results provide some important insights into the overall philosophy and underlying participants' conception of what sustainable development of Los Roques NP means. This conception is broadly shared by stakeholders as they coincided in the weights of most of the criteria, which were assigned individually through the questionnaire. It is particularly noteworthy that tourists and environmentalists almost fully match in their assessments of criteria but not of the alternatives. Moreover, there is a great agreement in the final assessment. This suggests that the regular contact among the different stakeholders, i.e. tourists with inhabitants, authorities with environmentalists, tour operators with representatives of the ministry, etc. has led to a common understanding of the opportunities and threats for the NP. They all agreed that the procedure enhances participation and transparency and it is a necessary source of information and support for their decisions.

  9. Competencies of specialised wound care nurses: a European Delphi study.

    PubMed

    Eskes, Anne M; Maaskant, Jolanda M; Holloway, Samantha; van Dijk, Nynke; Alves, Paulo; Legemate, Dink A; Ubbink, Dirk T; Vermeulen, Hester

    2014-12-01

    Health care professionals responsible for patients with complex wounds need a particular level of expertise and education to ensure optimum wound care. However, uniform education for those working as wound care nurses is lacking. We aimed to reach consensus among experts from six European countries as to the competencies for specialised wound care nurses that meet international professional expectations and educational systems. Wound care experts including doctors, wound care nurses, lecturers, managers and head nurses were invited to contribute to an e-Delphi study. They completed online questionnaires based on the Canadian Medical Education Directives for Specialists framework. Suggested competencies were rated on a 9-point Likert scale. Consensus was defined as an agreement of at least 75% for each competence. Response rates ranged from 62% (round 1) to 86% (rounds 2 and 3). The experts reached consensus on 77 (80%) competences. Most competencies chosen belonged to the domain 'scholar' (n = 19), whereas few addressed those associated with being a 'health advocate' (n = 7). Competencies related to professional knowledge and expertise, ethical integrity and patient commitment were considered most important. This consensus on core competencies for specialised wound care nurses may help achieve a more uniform definition and education for specialised wound care nurses. PMID:23374671

  10. Competencies of specialised wound care nurses: a European Delphi study.

    PubMed

    Eskes, Anne M; Maaskant, Jolanda M; Holloway, Samantha; van Dijk, Nynke; Alves, Paulo; Legemate, Dink A; Ubbink, Dirk T; Vermeulen, Hester

    2014-12-01

    Health care professionals responsible for patients with complex wounds need a particular level of expertise and education to ensure optimum wound care. However, uniform education for those working as wound care nurses is lacking. We aimed to reach consensus among experts from six European countries as to the competencies for specialised wound care nurses that meet international professional expectations and educational systems. Wound care experts including doctors, wound care nurses, lecturers, managers and head nurses were invited to contribute to an e-Delphi study. They completed online questionnaires based on the Canadian Medical Education Directives for Specialists framework. Suggested competencies were rated on a 9-point Likert scale. Consensus was defined as an agreement of at least 75% for each competence. Response rates ranged from 62% (round 1) to 86% (rounds 2 and 3). The experts reached consensus on 77 (80%) competences. Most competencies chosen belonged to the domain 'scholar' (n = 19), whereas few addressed those associated with being a 'health advocate' (n = 7). Competencies related to professional knowledge and expertise, ethical integrity and patient commitment were considered most important. This consensus on core competencies for specialised wound care nurses may help achieve a more uniform definition and education for specialised wound care nurses.

  11. 76 FR 46852 - Workers From Kelly Services, Working On-Site at Delphi Automotive Systems, LLC, Powertrain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... Employment and Training Administration Workers From Kelly Services, Working On-Site at Delphi Automotive... workers from Kelly Services working on-site at Delphi Automotive Systems, LLC, El Paso, Texas. The workers... subject firm in its' entirety should read leased workers from Kelly Services, working on-site at...

  12. 78 FR 48467 - Delphi Automotive Systems, LLC, Products and Service Solutions Division, Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Department's notice of determination was published in the Federal Register on February 22, 2013 (Volume 78 FR... Employment and Training Administration Delphi Automotive Systems, LLC, Products and Service Solutions... workers of Delphi Automotive Systems, LLC, Product and Service Solutions Division, Original...

  13. Examining the Roles of Blended Learning Approaches in Computer-Supported Collaborative Learning (CSCL) Environments: A Delphi Study

    ERIC Educational Resources Information Center

    So, Hyo-Jeong; Bonk, Curtis J.

    2010-01-01

    In this study, a Delphi method was used to identify and predict the roles of blended learning approaches in computer-supported collaborative learning (CSCL) environments. The Delphi panel consisted of experts in online learning from different geographic regions of the world. This study discusses findings related to (a) pros and cons of blended…

  14. Development of criteria for evaluating clinical response in thyroid eye disease (CRI-TED) using a modified Delphi technique

    PubMed Central

    Douglas, Raymond S.; Tsirbas, Angelo; Gordon, Mark; Lee, Diana; Khadavi, Nicole; Garneau, Helene Chokron; Goldberg, Robert A.; Cahill, Kenneth; Dolman, Peter J.; Elner, Victor; Feldon, Steve; Lucarelli, Mark; Uddin, Jimmy; Kazim, Michael; Smith, Terry J.; Khanna, Dinesh

    2014-01-01

    To identify components of a provisional clinical response index for thyroid eye disease (CRI-TED) using a modified Delphi technique. The International Thyroid Eye Disease Society (ITEDS) conducted a structured, 3-round Delphi exercise establishing consensus for a core set of measures for clinical trials in TED. The steering committee discussed the results in a face-to-face meeting (nominal group technique) and evaluated each criterion with respect to its feasibility, reliability, redundancy, and validity. Redundant measures were consolidated or excluded. Criteria were parsed into 11 domains for the Delphi surveys. Eighty four respondents participated in the Delphi-1 survey, providing 220 unique items. Ninety- two members (100% of the respondents from Delphi 1 plus eight new participants) responded in Delphi-2 and rated the same 220 items. Sixty-four members (76% of participants) rated 153 criteria in Delphi-3 (67 criteria were excluded due to redundancy). Criteria with a mean greater than 6 (1 least appropriate to 9 most appropriate) were further evaluated by the nominal group technique and provisional core measures were chosen. Using a Delphi exercise, we developed provisional core measures for assessing disease activity and severity in clinical trials of therapies for TED. These measures will be iteratively refined for use in multicenter clinical trials. PMID:19752424

  15. Core Competencies of the Certified Pediatric Doctor of Chiropractic: Results of a Delphi Consensus Process.

    PubMed

    Hewitt, Elise; Hestbaek, Lise; Pohlman, Katherine A

    2016-04-01

    An outline of the minimum core competencies expected from a certified pediatric doctor of chiropractic was developed using a Delphi consensus process. The initial set of seed statements and substatements was modeled on competency documents used by organizations that oversee chiropractic and medical education. These statements were distributed to the Delphi panel, reaching consensus when 80% of the panelists approved each segment. The panel consisted of 23 specialists in chiropractic pediatrics (14 females) from across the broad spectrum of the chiropractic profession. Sixty-one percent of panelists had postgraduate pediatric certifications or degrees, 39% had additional graduate degrees, and 74% were faculty at a chiropractic institution and/or in a postgraduate pediatrics program. The panel were initially given 10 statements with related substatements formulated by the study's steering committee. On all 3 rounds of the Delphi process the panelists reached consensus; however, multiple rounds occurred to incorporate the valuable qualitative feedback received. PMID:26739669

  16. Developing a Framework for Ankle Function: A Delphi Study

    PubMed Central

    Snyder, Kelli R.; Evans, Todd A.; Neibert, Peter J.

    2014-01-01

    Context: Addressing clinical outcomes is paramount to providing effective health care, yet there is no consensus regarding the appropriate outcomes to address after ankle injuries. Compounding the problem is the repetitive nature of lateral ankle sprains, referred to as functional (FAI) or chronic (CAI) ankle instability. Although they are commonly used terms in practice and research, FAI and CAI are inconsistently defined and assessed. Objective: To establish definitions of a healthy/normal/noninjured ankle, FAI, and CAI, as well as their characteristics and assessment techniques. Design: Delphi study. Setting: Telephone interviews and electronic surveys. Patients or Other Participants: Sixteen experts representing the fields of ankle function and treatment, ankle research, and outcomes assessment and research were selected as panelists. Data Collection and Analysis: A telephone interview produced feedback regarding the definition of, functional characteristics of, and assessment techniques for a healthy/normal/noninjured ankle, an unhealthy/acutely injured ankle, and FAI/CAI. Those data were compiled, reduced, and returned through electronic surveys and were either included by reaching consensus (80% agreement) or excluded. Results: The definitions of a healthy/normal/noninjured ankle and FAI reached consensus. Experts did not agree on a definition of CAI. Eleven functional characteristics of a healthy/normal/noninjured ankle, 32 functional characteristics of an unhealthy/acutely injured ankle, and 13 characteristics of FAI were agreed upon. Conclusions: Although a consensus was reached regarding the definitions and functional characteristics of a healthy/normal/noninjured ankle and FAI, the experts could only agree on 1 characteristic to include in the FAI definition. Several experts did, however, provide additional comments that reinforced the differences in the interpretation of those concepts. Although the experts could not agree on the definition of CAI, its

  17. SOLID STATE ENERGY CONVERSION ALLIANCE DELPHI SOLID OXIDE FUEL CELL

    SciTech Connect

    Steven Shaffer; Sean Kelly; Subhasish Mukerjee; David Schumann; Gail Geiger; Kevin Keegan; Larry Chick

    2004-05-07

    The objective of this project is to develop a 5 kW Solid Oxide Fuel Cell power system for a range of fuels and applications. During Phase I, the following will be accomplished: Develop and demonstrate technology transfer efforts on a 5 kW stationary distributed power generation system that incorporates steam reforming of natural gas with the option of piped-in water (Demonstration System A). Initiate development of a 5 kW system for later mass-market automotive auxiliary power unit application, which will incorporate Catalytic Partial Oxidation (CPO) reforming of gasoline, with anode exhaust gas injected into an ultra-lean burn internal combustion engine. This technical progress report covers work performed by Delphi from July 1, 2003 to December 31, 2003, under Department of Energy Cooperative Agreement DE-FC-02NT41246. This report highlights technical results of the work performed under the following tasks: Task 1 System Design and Integration; Task 2 Solid Oxide Fuel Cell Stack Developments; Task 3 Reformer Developments; Task 4 Development of Balance of Plant (BOP) Components; Task 5 Manufacturing Development (Privately Funded); Task 6 System Fabrication; Task 7 System Testing; Task 8 Program Management; Task 9 Stack Testing with Coal-Based Reformate; and Task 10 Technology Transfer from SECA CORE Technology Program. In this reporting period, unless otherwise noted Task 6--System Fabrication and Task 7--System Testing will be reported within Task 1 System Design and Integration. Task 8--Program Management, Task 9--Stack Testing with Coal Based Reformate, and Task 10--Technology Transfer from SECA CORE Technology Program will be reported on in the Executive Summary section of this report.

  18. Drugs foresight 2020: a Delphi expert panel study

    PubMed Central

    2014-01-01

    Background Historically substance misuse has been relatively common in western countries, but comparatively few Finns report drug use. The Drugs 2020 study aimed at foreseeing changes in the drug situation in Finland by the year 2020. Methods The Delphi method was used, utilizing drug experts of the EU national network in Finland. Results Marked growth was foreseen in drug use, especially in synthetic designer drugs and misuse of medicinal drugs. Significant increase was also expected in growing cannabis at home. However, the control of drug market was expected to shift more into the hands of organized crime. No consensus was reached on how drug prices will develop in the time period. Drug use is likely to remain punishable although the use and possession of cannabis may be treated less severely. It seems likely that health and social services resources will be directed towards medicinal treatment. Conclusions Foresight can be utilized in preparing for the future; desirable developments can be fostered, and measures can be taken to curb probable but undesirable lines of development. Based on the results of this study, the experts’ view is that it is highly likely that the Finnish society will have to prepare for an increase in the demand for drug-related care, both in terms of content of the care and financing the services. Also, the forecasted increase in the role of legal prescription medicine used as intoxicants will call for efforts not only in changing prescription practices but in border and police control measures, as well. Parallel developments have been foreseen in the UK and Sweden, and it is likely that similar trends will actualize also in other western countries. PMID:24885142

  19. Core competencies for UK occupational health nurses: a Delphi study

    PubMed Central

    Demou, E.; Kiran, S.; Gaffney, M.; Stevenson, M.; Macdonald, E. B.

    2016-01-01

    Background Occupational health nurses (OHNs) play a pivotal role in the delivery of occupational health (OH) services. Specific competency guidance has been developed in a number of countries, including the UK. While it is acknowledged that UK OHN practice has evolved in recent years, there has been no formal research to capture these developments to ensure that training and curricula remain up-to-date and reflect current practice. Aims To identify current priorities among UK OHNs of the competencies required for OH practice. Methods A modified Delphi study undertaken among representative OHN networks in the UK. This formed part of a larger study including UK and international occupational physicians. The study was conducted in two rounds using a questionnaire based on available guidance on training competencies for OH practice, the published literature, expert panel reviews and conference discussions. Results Consensus among OHNs was high with 7 out of the 12 domains scoring 100% in rating. ‘Good clinical care’ was the principal domain ranked most important, followed by ‘general principles of assessment & management of occupational hazards to health’. ‘Research methods’ and ‘teaching & educational supervision’ were considered least important. Conclusions This study has established UK OHNs’ current priorities on the competencies required for OH practice. The timing of this paper is opportune with the formal launch of the Faculty of Occupational Health Nursing planned in 2018 and should inform the development of competency requirements as part of the Faculty’s goals for standard setting in OHN education and training. PMID:27492470

  20. Language Interference and Language Learning Techniques Transfer in L2 and L3 Immersion Programs.

    ERIC Educational Resources Information Center

    Aronin, Larissa; Toubkin, Lynne

    2002-01-01

    Examines the relationships between the first (L1), second (L2), and third (L3) language in immersion programs for Russian-speaking students in Israel. Two parallel and similar immersion programs, which were carried out for the same population, but with different target languages (L2 Hebrew and L3 English), are described. Presents tentative…

  1. L3 Syntactic Transfer Selectivity and Typological Determinacy: The Typological Primacy Model

    ERIC Educational Resources Information Center

    Rothman, Jason

    2011-01-01

    The present article addresses the following question: what variables condition syntactic transfer? Evidence is provided in support of the position that third language (L3) transfer is selective, whereby, at least under certain conditions, it is driven by the typological proximity of the target L3 measured against the other previously acquired…

  2. L2 and L3 Ultimate Attainment: An Investigation of Two Parameters

    ERIC Educational Resources Information Center

    Hermas, Abdelkader

    2014-01-01

    This study considers the upper limit of ultimate attainment in the L2 French and L3 English of trilingual learners. The learners are native speakers of Moroccan Arabic who started learning L2 French at eight and L3 English at 16. They are advanced in both languages. Four constructions representing the verb movement and null subject parameter were…

  3. Examining the Impact of L2 English on L3 Selves: A Case Study

    ERIC Educational Resources Information Center

    Henry, Alastair

    2011-01-01

    In this Swedish case study of four upper secondary students engaged in simultaneous second language (L2; English) and third language (L3; Spanish, French and Russian) learning, a possible selves perspective was used to investigate the impact of English on L3 motivation. Using a maximum variation sampling strategy, participants were selected from a…

  4. The Acquisition of L3 English Vowels by Infant German-Italian Bilinguals

    ERIC Educational Resources Information Center

    Missaglia, Federica

    2010-01-01

    This paper is concerned with a specific case of L3 acquisition: the starting position for English vowel acquisition by infant German-Italian bilinguals will be investigated in light of prototype theory. The chosen example of triple language contact is characterised by consecutive bilingualism as the basis of L3 acquisition, where the learners' L2…

  5. The Bilingual Advantage in L3 Learning: A Developmental Study of Rhotic Sounds

    ERIC Educational Resources Information Center

    Kopecková, Romana

    2016-01-01

    Facilitative effects of bilingualism on general aspects of third language (L3) proficiency have been demonstrated in numerous studies conducted in bilingual communities and classrooms around the world. When it comes to L3 phonology, however, empirical evidence has been scarce and inconclusive in respect to the question of whether and/or how…

  6. Seeking consensus through the use of the Delphi technique in health sciences research.

    PubMed

    Falzarano, Mary; Pinto Zipp, Genevieve

    2013-01-01

    The purposes of this paper are to explain how the Delphi technique has been used as a research methodology for seeking consensus among experts in the health science literature and to offer a model for its future use. The authors discuss the proposed model by exploring how the Delphi technique was used to develop a survey tool to explore mentoring practices of health science faculty members. The authors' aims are to explain the use of this methodological approach in obtaining face and content validity of survey tools and to apprize the scholarly community in the health sciences of the relevance of the model.

  7. Review of weak mixing angle results at SLC and LEP

    SciTech Connect

    Woods, M.

    1995-10-01

    In this paper, the authors review recent precise measurements of the weak mixing angle by the SLD experiment at SLC and by the ALEPH, DELPHI, L3, and OPAL experiments at LEP. If they assume that the Minimal Standard Model provides a complete description of the quark and lepton couplings to the Z boson, they find sin{sup 2} {theta}{sub W}{sup eff} = 0.23143 {+-} 0.00028. If this assumption is relaxed to apply to lepton couplings only, they find sin{sup 2}{theta}{sub W}{sup eff} = 0.23106 {+-} 0.00035. They compare these results with other precision electroweak tests.

  8. Search for CP Violating Neutral Higgs Bosons in the MSSM at LEP

    SciTech Connect

    Bechtle, Philip; /SLAC

    2006-03-13

    The LEP collaborations ALEPH, DELPHI, L3 and OPAL have searched for the neutral Higgs bosons which are predicted within the framework of the Minimal Supersymmetric Standard Model (MSSM). The data of the four collaborations are statistically combined and show no significant excess of events which would indicate the production of Higgs bosons. The search results are thus used to set upper bounds on the cross sections of various Higgs-like event topologies and limits on MSSM benchmark models, including CP-conserving and CP-violating scenarios. Here, the limits on the model parameters of the CP-violating benchmark scenario CPX and derivates of this scenario are shown.

  9. Constraints on the Z-Z Prime mixing angle from data measured for the process e{sup +}e{sup -} {yields} W{sup +}W{sup -} at the LEP2 collider

    SciTech Connect

    Andreev, Vas. V.; Pankov, A. A.

    2012-01-15

    An analysis of effects induced by new neutral gauge Z Prime bosons was performed on the basis of data from the OPAL, DELPHI, ALEPH, and L3 experiments devoted to measuring differential cross sections for the process of the annihilation production of pairs of charged gauge W{sup {+-}} bosons at the LEP2 collider. By using these experimental data, constraints on the Z Prime -boson mass and on the angle of Z-Z Prime mixing were obtained for a number of extended gauge models.

  10. Mutations in the Bacterial Ribosomal Protein L3 and Their Association with Antibiotic Resistance

    PubMed Central

    Klitgaard, Rasmus N.; Ntokou, Eleni; Nørgaard, Katrine; Biltoft, Daniel; Hansen, Lykke H.; Trædholm, Nicolai M.; Kongsted, Jacob

    2015-01-01

    Different groups of antibiotics bind to the peptidyl transferase center (PTC) in the large subunit of the bacterial ribosome. Resistance to these groups of antibiotics has often been linked with mutations or methylations of the 23S rRNA. In recent years, there has been a rise in the number of studies where mutations have been found in the ribosomal protein L3 in bacterial strains resistant to PTC-targeting antibiotics but there is often no evidence that these mutations actually confer antibiotic resistance. In this study, a plasmid exchange system was used to replace plasmid-carried wild-type genes with mutated L3 genes in a chromosomal L3 deletion strain. In this way, the essential L3 gene is available for the bacteria while allowing replacement of the wild type with mutated L3 genes. This enables investigation of the effect of single mutations in Escherichia coli without a wild-type L3 background. Ten plasmid-carried mutated L3 genes were constructed, and their effect on growth and antibiotic susceptibility was investigated. Additionally, computational modeling of the impact of L3 mutations in E. coli was used to assess changes in 50S structure and antibiotic binding. All mutations are placed in the loops of L3 near the PTC. Growth data show that 9 of the 10 mutations were well accepted in E. coli, although some of them came with a fitness cost. Only one of the mutants exhibited reduced susceptibility to linezolid, while five exhibited reduced susceptibility to tiamulin. PMID:25845869

  11. The Criticality of Verbal Immediacy in Online Instruction: A Modified Delphi Study

    ERIC Educational Resources Information Center

    Bailie, Jeffrey L.

    2012-01-01

    In this 2011 investigation, a modified Delphi technique was introduced to determine whether an informed group of post-secondary online faculty and students could arrive at a consensus regarding the importance of previously recognized verbal immediacy behaviors. Two expert panels were presented with Gorham's (1988) Verbal Immediacy Scale and tasked…

  12. A Classical Delphi Study to Identify the Barriers of Pursuing Green Information and Communication Technologies

    ERIC Educational Resources Information Center

    Gotay, Jose Antonio

    2013-01-01

    This qualitative, classical Delphi study served to explore the apparent lack of corporate commitment to prioritized Green Information Communication Technologies (ICTs), which could delay the economic and social benefits for maximizing the use of natural energy resources in a weak economy. The purpose of this study was to examine the leadership…

  13. A Quality Scorecard for the Administration of Online Education Programs: A Delphi Study

    ERIC Educational Resources Information Center

    Shelton, Kaye

    2010-01-01

    As the demands for public accountability increase for the higher education, institutions are seeking methods for continuous improvement in order to demonstrate quality within programs and processes, including those provided through online education. A six round Delphi study was undertaken with 43 seasoned administrators of online education…

  14. Assessment Leaders' Perspectives of Institutional Cultures of Assessment: A Delphi Study

    ERIC Educational Resources Information Center

    Fuller, Matthew; Henderson, Susan; Bustamante, Rebecca

    2015-01-01

    Institutional cultures of assessment are praised as beneficial to student learning. Yet, extant studies have not explored the theoretical foundations and pragmatic approaches to shaping cultures of assessment. The researchers used the Delphi method to explore 10 higher education assessment leaders' attitudes and theoretical perspectives regarding…

  15. Development of a School Nursing Research Agenda in Florida: A Delphi Study

    ERIC Educational Resources Information Center

    Gordon, Shirley C.; Barry, Charlotte D.

    2006-01-01

    Research is important to the image, visibility, and viability of school nursing. Each state school nursing association should evaluate member commitment to school nursing research based on their unique set of financial, educational, and organizational resources. A 3-round Delphi study was conducted in which Florida school nurses identified…

  16. The Semiconductor Industry and Emerging Technologies: A Study Using a Modified Delphi Method

    ERIC Educational Resources Information Center

    Jordan, Edgar A.

    2010-01-01

    The purpose of this qualitative descriptive study was to determine what leaders in the semiconductor industry thought the future of computing would look like and what emerging materials showed the most promise to overcome the current theoretical limit of 10 nanometers for silicon dioxide. The researcher used a modified Delphi technique in two…

  17. Assessing the Trends and Challenges of Teaching Marketing Abroad: A Delphi Approach

    ERIC Educational Resources Information Center

    Kelley, Craig A.

    2007-01-01

    The past 20 years have seen a growth in the teaching of marketing in business schools around the world. This article reports the trends and challenges that will face U.S. marketing educators teaching abroad over the next 10 years. Predictions are from a Delphi panel of U.S. marketing educators experienced in teaching marketing abroad to non-U.S.…

  18. Towards an Understanding of Instructional Design Heuristics: An Exploratory Delphi Study

    ERIC Educational Resources Information Center

    York, Cindy S.; Ertmer, Peggy A.

    2011-01-01

    Evidence suggests that experienced instructional designers often use heuristics and adapted models when engaged in the instructional design problem-solving process. This study used the Delphi technique to identify a core set of heuristics designers reported as being important to the success of the design process. The overarching purpose of the…

  19. Recommended Skill Requirements of Recent Management Information Systems Graduates for Employment: A Modified Delphi Study

    ERIC Educational Resources Information Center

    Strnad, Michael A., Sr.

    2013-01-01

    The purpose of this Modified Delphi study was to achieve a consensus and forecast a prediction from expert IT hiring managers on what skills are required of MIS graduates for employment. In doing so, guidance could be provided to academic leaders who design curricula for MIS students on the required skills for employment. This study was conducted…

  20. 75 FR 41521 - Delphi Corporation, Automotive Holding Group, Plant 6, Currently Known as General Motors...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ..., Flint, Michigan and Delphi Corporation, Automotive Holding Group, Plant 2, including on-site leased workers from Securitas, EDS, Bartech and Mays Chemicals, Flint, ] Michigan. The Department's Notice of..., Mays Chemicals, Interim Physicians, LLC and HSS Material Management, Flint, Michigan (TA-W-62,069)...

  1. 75 FR 41521 - Delphi Corporation, Automotive Holding Group, Instrument Cluster Plant, Currently Known as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ..., including on-site leased workers from Securitas, EDS, Bartech and Mays Chemicals, Flint, Michigan. The... on-site at the Flint, Michigan location of Delphi Corporation. The Department has determined that... Holding Group, Instrument Cluster Plant, currently known as General Motors Corporation, Flint,...

  2. Identifying the Professional Development Needs of Adjunct Faculty Using an Online Delphi

    ERIC Educational Resources Information Center

    Cuddie, Stephani B.

    2016-01-01

    The purpose of this online Delphi was to explore the professional development needs and preferences of adjunct faculty, specifically those who teach online. The study involved adjunct faculty who were categorized by their self-selected type of adjunct faculty member: specialist, aspiring academic, professional/freelancer, and career-ender. Through…

  3. A Modified Delphi Technique for Obtaining Consensus on Institutional Research Priorities. Research Brief.

    ERIC Educational Resources Information Center

    Hecht, Alfred R.

    This document describes a modified Delphi technique for use in establishing research needs and priorities at the institutional level. Six steps are essential to the technique: identification of needs, collection of rankings of the relative importance of the identified needs by institutional administrators, calculation of the rank of identified…

  4. Workplace Issues in Extension--A Delphi Study of Extension Educators

    ERIC Educational Resources Information Center

    Kroth, Michael; Peutz, Joey

    2011-01-01

    Using the Delphi technique, expert Extension educators identified and prioritized those workplace issues they believe will be the most important to attract, motivate, and retain Extension educators/agents over the next 5 to 7 years. Obtaining and then utilizing a talented, highly motivated workforce during a period when many will be retiring will…

  5. Identification of Researchable Topics on International Agricultural Education. A Delphi Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.; Madou-Bangurah, Kabba

    A modified Delphi technique was used to identify topics in international agricultural education considered by eight experts on agricultural education to be areas needing research. All eight (100%) of the experts completed the first-round mail questionnaire, and seven (87.5%) completed the second and third rounds. Survey category areas were as…

  6. The Future of Information Literacy in Academic Libraries: A Delphi Study

    ERIC Educational Resources Information Center

    Saunders, Laura

    2009-01-01

    Information literacy is a central tenet of academic librarianship. However, technological advancements coupled with drastic changes in users' information needs and expectations are having a great impact on this service, leading practitioners to wonder how programs may evolve. Based on a Delphi study, this article surveyed 13 information literacy…

  7. A Delphi Survey on Citizenship Education in Asean Countries: Findings for Brunei

    ERIC Educational Resources Information Center

    Salleh, Hajah Sallimah Haji Mohammed; Laxman, Kumar; Jawawi, Rosmawijah

    2015-01-01

    The aim of the Delphi Survey was to elucidate Bruneian Education experts' responses to five questions regarding their knowledge and understanding of the charateristics of citizenship education viz. Environment, Coexistence, Culture, Social Justice and Equity, Democracy, Sustainable Development, Interdependence, Foreign Language, Social Welfare,…

  8. A Delphi Investigation into Future Trends in E-Learning in Israel

    ERIC Educational Resources Information Center

    Aharony, Noa; Bronstein, Jenny

    2014-01-01

    The purpose of this study is to investigate the views and opinions of e-learning experts regarding future trends in the e-learning arena. The Delphi technique was chosen as a method of study. This technique is an efficient and effective group communication process designed to systematically elicit judgments from experts in their selected area of…

  9. Modified Delphi Investigation of Exercise Science in Physical Education Teacher Education

    ERIC Educational Resources Information Center

    Bulger, Sean M.; Housner, Lynn D.

    2007-01-01

    The purpose of this study was to determine the critical exercise science competencies and associated instructional methods recommended for inclusion in the physical education teacher education curriculum. The two-round modified Delphi procedure involved the repeated circulation of a questionnaire to a small panel of content experts. The Delphi…

  10. Identifying Core Mobile Learning Faculty Competencies Based Integrated Approach: A Delphi Study

    ERIC Educational Resources Information Center

    Elbarbary, Rafik Said

    2015-01-01

    This study is based on the integrated approach as a concept framework to identify, categorize, and rank a key component of mobile learning core competencies for Egyptian faculty members in higher education. The field investigation framework used four rounds Delphi technique to determine the importance rate of each component of core competencies…

  11. Identification of Core Competencies for an Undergraduate Food Safety Curriculum Using a Modified Delphi Approach

    ERIC Educational Resources Information Center

    Johnston, Lynette M.; Wiedmann, Martin; Orta-Ramirez, Alicia; Oliver, Haley F.; Nightingale, Kendra K.; Moore, Christina M.; Stevenson, Clinton D.; Jaykus, Lee-Ann

    2014-01-01

    Identification of core competencies for undergraduates in food safety is critical to assure courses and curricula are appropriate in maintaining a well-qualified food safety workforce. The purpose of this study was to identify and refine core competencies relevant to postsecondary food safety education using a modified Delphi method. Twenty-nine…

  12. Reflections of Tomorrow: Lifelong Learning and the Public Library (A Delphi Study). Excerpts.

    ERIC Educational Resources Information Center

    Weingand, Darlene E.

    This study focuses on the question of whether the public library can or will be one of the non-formal providers of lifelong learning in Minnesota, and uses the Delphi method to discover in what way the public library as it is perceived by various publics could become an active participant in this dimension of the educational process. Five groups…

  13. Development of a Computer-Assisted Instruction (CAI) Program on the Delphi Technique.

    ERIC Educational Resources Information Center

    McCurdy, Carol

    The concept of Delphi technique was presented in a computer-assisted instruction (CAI) module designed for educational administration classes or inservice training of administrators. Instructional Dialogue Facility (IDF) Author Language on a 2000F Hewlett-Packard time-sharing system was used to write the sequence. Instructional objectives,…

  14. Development of an Adolescent Alcohol Misuse Intervention Based on the Prototype Willingness Model: A Delphi Study

    ERIC Educational Resources Information Center

    Davies, Emma; Martin, Jilly; Foxcroft, David

    2016-01-01

    Purpose: The purpose of this paper is to report on the use of the Delphi method to gain expert feedback on the identification of behaviour change techniques (BCTs) and development of a novel intervention to reduce adolescent alcohol misuse, based on the Prototype Willingness Model (PWM) of health risk behaviour. Design/methodology/approach: Four…

  15. Expert consensus building using e-Delphi for necrotizing enterocolitis risk assessment

    PubMed Central

    Gephart, Sheila M.; Effken, Judith A.; McGrath, Jacqueline M.; Reed, Pamela G.

    2013-01-01

    Objective To confirm content validity of GutCheckNEC, a risk index for necrotizing enterocolitis (NEC) and to determine the level of agreement among experts about NEC risk factors in premature infants. Design Electronic Delphi method (e-Delphi). Setting Online electronic surveys and email communication supported by an interactive study website. Participants Nurses and physicians (N=35) from four countries and across the United States who rated themselves as at least moderately expert about NEC risk. Methods e-Delphi involved three rounds of surveys and qualitative thematic analysis of experts’ comments. Surveys continued until criteria for consensus and/or stability were met. Results Of 64 initial items, 43 were retained representing 33 risk factors (final GutCheckNEC CVI=.77). Two broad themes about NEC risk emerged from 242 comments: the impact of individual physiologic vulnerability and variation in neonatal intensive care unit (NICU) clinicians’ practices. Controversy arose over the impact of treatments on NEC, including probiotics, packed red blood cell (PRBC) transfusions, and patent ductus arteriosus (PDA) management using indomethacin. Conclusion GutCheckNEC achieved borderline content validity for a new scale. The e-Delphi process yielded a broad perspective on areas in which experts both share and lack consensus on NEC risk. Future testing is underway to reduce the number of risk items to the most parsimonious set for a clinically useful risk tool and test reliability. PMID:23600525

  16. Comparing Management Models of Secondary Schools in Tamaulipas, Mexico: An Exploration with a Delphi Method

    ERIC Educational Resources Information Center

    Navarro-Leal, Marco Aurelio; Garcia, Concepcion Nino; Saldivar, Luisa Caballero

    2012-01-01

    For a preliminary exploration of management models between two secondary schools, a Delphi method was used in order to identify and focus relevant topics for a larger research. A first approximation with this method proved to be a heuristic tool to focus and define some categories and guidelines of enquiry. It was found that in both of the schools…

  17. A Delphi Study on Technology Enhanced Learning (TEL) Applied on Computer Science (CS) Skills

    ERIC Educational Resources Information Center

    Porta, Marcela; Mas-Machuca, Marta; Martinez-Costa, Carme; Maillet, Katherine

    2012-01-01

    Technology Enhanced Learning (TEL) is a new pedagogical domain aiming to study the usage of information and communication technologies to support teaching and learning. The following study investigated how this domain is used to increase technical skills in Computer Science (CS). A Delphi method was applied, using three-rounds of online survey…

  18. Co-Creating Nano-Imaginaries: Report of a Delphi-Exercise

    ERIC Educational Resources Information Center

    Deblonde, Marian; Van Oudheusden, Michiel; Evers, Johan; Goorden, Lieve

    2008-01-01

    In the first phase of the research project Nanotechnologies for Tomorrow's Society (www.nanosoc.be), the research consortium explored a variety of futuristic visions or technoscientific imaginaries. This exploration took the form of a Policy Delphi, adapted to the particular objective of jointly constructing nano-imaginaries, taking participants'…

  19. Consulting the Delphi: A New Idea for Collecting Student Feedback through the Two Survey Method (TSM)

    ERIC Educational Resources Information Center

    Finelli, Cynthia J.; Wright, Mary C.; Pinder-Grover, Tershia

    2010-01-01

    The Two Survey Method (TSM) is a new time-efficient tool for gathering formative student feedback. Based on the Delphi technique, the TSM uses iterative surveys to develop student consensus about key strengths and suggestions for instruction. Evaluation data indicate that both faculty and students are satisfied with the method's efficiency and the…

  20. Delphi in Criminal Justice Policy: A Case Study on Judgmental Forecasting

    ERIC Educational Resources Information Center

    Loyens, Kim; Maesschalck, Jeroen; Bouckaert, Geert

    2011-01-01

    This article provides an in-depth case study analysis of a pilot project organized by the section "Strategic Analysis" of the Belgian Federal Police. Using the Delphi method, which is a judgmental forecasting technique, a panel of experts was questioned about future developments of crime, based on their expertise in criminal or social trends. The…

  1. Incorporating Nonparametric Statistics into Delphi Studies in Library and Information Science

    ERIC Educational Resources Information Center

    Ju, Boryung; Jin, Tao

    2013-01-01

    Introduction: The Delphi technique is widely used in library and information science research. However, many researchers in the field fail to employ standard statistical tests when using this technique. This makes the technique vulnerable to criticisms of its reliability and validity. The general goal of this article is to explore how…

  2. Consensus and Controversy in Sexual Assault Prevention and Intervention: A Delphi Study.

    ERIC Educational Resources Information Center

    Brown, Vivian B.; And Others

    Sexual assault literature reveals inconsistencies regarding important issues in establishing prevention and intervention standards. The Delphi inquiry technique was used to examine concepts and criteria for practice and to explore assumptions and value dilemmas in sexual assault prevention and treatment. Expert judgments were made by 51…

  3. Increasing Activeness and Learning Outcomes by Developing Borland Delphi 7.0 Application as Instructional Media

    ERIC Educational Resources Information Center

    Setyorini, Dyna; Churiyah, Madziatul

    2016-01-01

    This study aims to produce instructional media of petty cash fund with Borland Delphi 7.0 application in the Finance Administration subject, Managing Petty Cash Fund material in class XII APK in Vocational High School (SMK) Negeri 1 Pasuruan, East Java, Indonesia. This study used "Research and Development" (R&D) design procedures…

  4. Endocarditis associated with Wohlfahrtiimonas chitiniclastica in a short-beaked common dolphin (Delphinus delphis).

    PubMed

    Josue, Diaz-Delgado; Eva, Sierra; Isabel, Vela Ana; Lucas, Dominguez; Marisa, Andrada; Manuel, Arbelo; Antonio, Fernandez

    2015-01-01

    Wohlfahrtiimonas chitiniclastica is a rare cause of fatal septicemia in humans, and recently reported in a white-tailed deer (Odocoileus virginianus). We describe fatal septicemia associated with W. chitiniclastica in a short-beaked common dolphin (Delphinus delphis) with fibrinosuppurative and necrotizing pulmonic, aortic, and mitral valve endocarditis. PMID:25375942

  5. Current Developments in Education in Mexico and Trends for the 1980s: A Modified Delphi Project.

    ERIC Educational Resources Information Center

    Sanders, Stanley G.

    Twenty-nine professional educators at the Universidad Autonoma de Guadalajara and post-graduate students of educational administration participated in a study to identify trends in education based on change in the society and the environment. Researchers used a modification of Delphi Technique, an intuitive method for organizing and sharing the…

  6. The Learner-Centered Instructional Design Model: A Modified Delphi Study

    ERIC Educational Resources Information Center

    Melsom, Duane Allan

    2010-01-01

    The learner-centered instructional design model redefines the standard linear instructional design model to form a circular model where the learner's needs are the first item considered in the development of instruction. The purpose of this modified Delphi study was to have a panel of experts in the instructional design field review the…

  7. The Competencies and Characteristics Required of an Effective Project Manager: A Web-Based Delphi Study

    ERIC Educational Resources Information Center

    Brill, Jennifer M.; Bishop, M. J.; Walker, Andrew E.

    2006-01-01

    In this study, we explore the competencies required for a project manager to be effective in the workplace. We used a Web-based Delphi method to lead experienced project managers through an anonymous consensus-building process consisting of two rounds of surveys. The Round I analysis of 147 respondents, all with 20 or more years of project…

  8. Research Priorities for YouTube and Video-Sharing Technologies: A Delphi Study

    ERIC Educational Resources Information Center

    Snelson, Chareen; Rice, Kerry; Wyzard, Constance

    2012-01-01

    Online video-sharing services, particularly YouTube, have gained an audience of billions of users including educators and scholars. While the academic literature provides some evidence that YouTube has been studied and written about, little is known about priorities for YouTube research. The study employed the Delphi method to obtain a consensus…

  9. Designing Graduate-Level Plant Breeding Curriculum: A Delphi Study of Private Sector Stakeholder Opinions

    ERIC Educational Resources Information Center

    Miller, Jane K.; Repinski, Shelby L.; Hayes, Kathryn N.; Bliss, Frederick A.; Trexler, Cary J.

    2011-01-01

    A broad-based survey using the Delphi method was conducted to garner current information from private sector stakeholders and build consensus opinions supporting key ideas for enhancing plant breeder education and training. This study asked respondents to suggest and rate topics and content they deemed most important to plant breeding graduate…

  10. Factors Influencing Continuing Professional Development: A Delphi Study among Nursing Experts

    ERIC Educational Resources Information Center

    Brekelmans, Gerard; Poell, Rob F.; van Wijk, Kees

    2013-01-01

    Purpose: The aim of this paper is to present an inventory of expert opinions on the factors that influence the participation of registered nurses in continuing professional development (CPD) activities. Design/methodology/approach: A Delphi study was conducted among 38 Dutch experts (nursing employers, managers, education institutions, and…

  11. Financial Leadership Competencies for Public College and University Presidential Leaders in Georgia: A Delphi Study

    ERIC Educational Resources Information Center

    Jones, Susan M.

    2011-01-01

    The purpose of the mixed-method Delphi study is to identify the financial leadership competencies considered most important in operating public higher education institutions. The current study also determined whether differences existed in the perceptions of participants' age, level of education, years of service as a president, the number of…

  12. Trends that FCS Education Should Address: A Delphi Study Reveals Top 16

    ERIC Educational Resources Information Center

    Alexander, Karen L.; Davis, Kimberlee

    2011-01-01

    This study used the Delphi method to identify trends of importance to family and consumer sciences (FCS) education. A panel of 21 FCS education experts identified 16 trends and evaluated them by importance, desirability, feasibility, and confidence in validity of the trend. Nutrition appeared as a top priority, followed by consumer economics. The…

  13. Mode analysis of photonic crystal L3 cavities in self-suspended lithium niobate membranes

    SciTech Connect

    Diziain, Séverine Geiss, Reinhard; Zilk, Matthias; Schrempel, Frank; Kley, Ernst-Bernhard; Pertsch, Thomas; Tünnermann, Andreas

    2013-12-16

    We report on a multimodal analysis of photonic crystal L3 cavities milled in lithium niobate free-standing membranes. The classical L3 cavity geometry is compared to an L3 cavity containing a second lattice superimposed on the primary one. Those two different geometries are investigated in terms of vertical radiation and quality (Q) factor for each mode of the cavities. Depending on the cavity geometry, some modes undergo an enhancement of their vertical radiation into small angles while other modes experience a higher Q factor. Experimental characterizations are corroborated by three-dimensional finite difference time domain simulations.

  14. Critical roles of DNase1l3l in lens nuclear degeneration in zebrafish.

    PubMed

    Iida, Atsumi; Tabata, Yoko; Baba, Yukihiro; Fujii, Tomoaki; Watanabe, Sumiko

    2014-11-01

    The vertebrate lens undergoes organelle and nuclear degradation during lens development, allowing the lens to become transparent. DNase2b is an enzyme responsible for nuclear degradation in the mouse lens; however, dnase2b expression in zebrafish showed a distribution pattern that differed from that in mice. No zebrafish dnase2b was detected by reverse-transcription polymerase chain reaction until around 120 h postfertilization (hpf), suggesting that dnase2b is not expressed in the critical period for lens nuclear degradation, which corresponds to 56-74 hpf. However, public database searches have indicated that dnase1l3l is strongly and specifically expressed in embryonic zebrafish lens. Whole mount in situ hybridization showed that dnase1l3l expression began around 36 hpf and was found exclusively in the lens until the adult stage. Morpholino (MO)-dependent downregulation of dnase1l3l expression during early development in zebrafish led to the failure of nuclear degradation in the lens. Immunostaining of lens sections showed that expression of Pax6, Prox1 and β-catenin was comparable to the control in the early stage of development in dnase1l3l-MO injected embryos. However, downregulation of expression of these genes in lens was not observed in dnase1l3l-MO-treated zebrafish at 72 hpf, suggesting that the lens development was halted. Taken together, we showed that dnase1l3l plays major roles in nuclear degradation in zebrafish lens development. No homologous gene was found in other species in public databases, suggesting that dnase1l3l developed and acquired its function specifically in zebrafish.

  15. DelPhi Web Server: A comprehensive online suite for electrostatic calculations of biological macromolecules and their complexes.

    PubMed

    Sarkar, Subhra; Witham, Shawn; Zhang, Jie; Zhenirovskyy, Maxim; Rocchia, Walter; Alexov, Emil

    2013-01-01

    Here we report a web server, the DelPhi web server, which utilizes DelPhi program to calculate electrostatic energies and the corresponding electrostatic potential and ionic distributions, and dielectric map. The server provides extra services to fix structural defects, as missing atoms in the structural file and allows for generation of missing hydrogen atoms. The hydrogen placement and the corresponding DelPhi calculations can be done with user selected force field parameters being either Charmm22, Amber98 or OPLS. Upon completion of the calculations, the user is given option to download fixed and protonated structural file, together with the parameter and Delphi output files for further analysis. Utilizing Jmol viewer, the user can see the corresponding structural file, to manipulate it and to change the presentation. In addition, if the potential map is requested to be calculated, the potential can be mapped onto the molecule surface. The DelPhi web server is available from http://compbio.clemson.edu/delphi_webserver.

  16. DelPhi Web Server: A comprehensive online suite for electrostatic calculations of biological macromolecules and their complexes

    PubMed Central

    Sarkar, Subhra; Witham, Shawn; Zhang, Jie; Zhenirovskyy, Maxim; Rocchia, Walter; Alexov, Emil

    2011-01-01

    Here we report a web server, the DelPhi web server, which utilizes DelPhi program to calculate electrostatic energies and the corresponding electrostatic potential and ionic distributions, and dielectric map. The server provides extra services to fix structural defects, as missing atoms in the structural file and allows for generation of missing hydrogen atoms. The hydrogen placement and the corresponding DelPhi calculations can be done with user selected force field parameters being either Charmm22, Amber98 or OPLS. Upon completion of the calculations, the user is given option to download fixed and protonated structural file, together with the parameter and Delphi output files for further analysis. Utilizing Jmol viewer, the user can see the corresponding structural file, to manipulate it and to change the presentation. In addition, if the potential map is requested to be calculated, the potential can be mapped onto the molecule surface. The DelPhi web server is available from http://compbio.clemson.edu/delphi_webserver. PMID:24683424

  17. ESA’s L3 mission: A space-based gravitational-wave observatory

    NASA Astrophysics Data System (ADS)

    Mueller, Guido

    2016-04-01

    ESA selected the Gravitational Universe as the science theme for one of its future L-class missions. L3 will measure gravitational waves in the 10µHz to 100mHz window; probably the richest of all gravitational wave windows. Expected sources in this frequency band range from massive black hole mergers to extreme mass ratio inspirals to compact galactic binary systems.The L3 mission is expected to be based on the eLISA/LISA design which was submitted by the eLISA consortium as a notional mission concept. NASA started discussions with ESA how to join L3 and participates in ESA’s Gravitational Observatory Advisory Team. NASA is also in the process of setting up its own L3-Study team to look at potential US contributions to L3. This group will also act as the US partner for the eLISA consortium. In summary, the space component of the GW community has gained significant momentum over the last 12 months and a successful pathfinder mission and potential GW discoveries by Advanced LIGO and/or pulsar timing arrays should further strengthen the case for LISA.

  18. Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension

    PubMed Central

    Liu, Xin; Hu, Cheng; Bao, Minghui; Li, Jing; Liu, Xiaoyan; Tan, Xuerui; Zhou, Yong; Chen, Yequn; Wu, Shouling; Chen, Shuohua; Zhang, Rong; Jiang, Feng; Jia, Weiping; Wang, Xingyu; Yang, Xinchun; Cai, Jun

    2016-01-01

    Hypertension is a major global health burden and a leading risk factor for cardiovascular diseases. Although its heritability has been documented previously, contributing loci identified to date account for only a small fraction of blood pressure (BP) variation, which strongly suggests the existence of undiscovered variants. To identify novel variants, we conducted a three staged genetic study in 21,990 hypertensive cases and normotensive controls. Four single nucleotide polymorphisms (SNPs) at three new genes (L3MBTL4 rs403814, Pmeta = 6.128 × 10−9; LOC729251, and TCEANC) and seven SNPs at five previously reported genes were identified as being significantly associated with hypertension. Through functional analysis, we found that L3MBTL4 is predominantly expressed in vascular smooth muscle cells and up-regulated in spontaneously hypertensive rats. Rats with ubiquitous over-expression of L3MBTL4 exhibited significantly elevated BP, increased thickness of the vascular media layer and cardiac hypertrophy. Mechanistically, L3MBTL4 over-expression could lead to down-regulation of latent transforming growth factor-β binding protein 1 (LTBP1), and phosphorylation activation of the mitogen-activated protein kinases (MAPK) signaling pathway, which is known to trigger the pathological progression of vascular remodeling and BP elevation. These findings pinpointed L3MBTL4 as a critical contributor to the development and progression of hypertension and uncovers a novel target for therapeutic intervention. PMID:27480026

  19. a Measurement of Charged Triple Gauge Couplings with Delphi at Lep

    NASA Astrophysics Data System (ADS)

    Tobin, Mark

    2003-02-01

    The data taken by DELPHI at centre of mass energies between 189 and 209 GeV is used to place preliminary limits on the Trilinear Gauge Boson Couplings (TGCs) associated to W+W- production at LEP2. The preliminary values of the parameters Δ gz1 , λγ and Δκγ were extracted from data with jjlv, jjjj and jjX final states, where j, l and X represent a jet, a lepton and missing energy respectively. These preliminary results are the first results from DELPHI with the inclusion of a complete set of O(αem) corrections to the W pair cross-section. All results were found to be in agreement with Standard Model predictions.

  20. Determinants of adolescents' ineffective and improved coping with cyberbullying: a Delphi study.

    PubMed

    Jacobs, Niels C L; Dehue, Francine; Völlink, Trijntje; Lechner, Lilian

    2014-06-01

    The study's aim was to obtain an overview of all relevant variables involved in ineffective coping behavior and improvement in coping behavior as it pertains to cyberbullying among adolescents, in order to systematically develop a theory- and evidence-based intervention. This was done by means of a three round online Delphi study. First, 20 key experts listed possible relevant determinants. Next, 70 experts scored these determinants on their relevance and finally, experts rerated relevance of each determinant based on group median scores. The experts agreed that 115 items are relevant for ineffective (62) or improvement in (53) coping behavior. New found determinants were the extent to which one can adjust behavior upon feedback, impulsivity, self-confidence, communication style, personality, decision-making skills, conflict resolution skills, previous participation in personal resilience training, social relationships, rumors and self-disclosure. We conclude that the Delphi technique is useful in discovering new and relevant determinants of behavior. PMID:24793384

  1. The DELPHI distributed information system for exchanging LEP machine related information

    NASA Astrophysics Data System (ADS)

    Dönszelmann, M.; Gaspar, C.

    1994-12-01

    An information management system was designed and implemented to interchange information between the DELPHI experiment at CERN and the monitoring/control system for the LEP (Large Electron Positron Collider) accelerator. This system is distributed and communicates with many different sources and destinations (LEP) using different types of communication. The system itself communicates internally via a communication system based on a publish-and-subscribe mechanism, DIM (Distributed Information Manager). The information gathered by this system is used for on-line as well as off-line data analysis. Therefore it logs the information to a database and makes it available to operators and users via DUI (DELPHI User Interface). The latter was extended to be capable of displaying "time-evolution" plots. It also handles a protocol, implemented using a finite state machine, SMI (State Management Interface), for (semi-)automatic running of the Data Acquisition System and the Slow Controls System.

  2. 76 FR 29274 - Interstate Electronics Corp., a Subsidiary of L-3 Communications Including On-Site Leased Workers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... Employment and Training Administration Interstate Electronics Corp., a Subsidiary of L-3 Communications... Electronics Corp., a subsidiary of L-3 Communications, including on-site leased workers from Bently Global... Interstate Electronics Corp., a subsidiary of L-3 Communications. The Department has determined that...

  3. Transfer to the Collinear Libration Point L3 in the Sun-Earth+Moon System

    NASA Technical Reports Server (NTRS)

    Hou, Xi-yun; Tang, Jing-shi; Liu, Lin

    2007-01-01

    The collinear libration point L3 of the sun-earth+moon system is an ideal place for some space missions. Although there has been a great amount of work concerning the applications of the other two collinear libration points L1 and L2, little work has been done about the point L3. In this paper, the dynamics of the libration points was briefly introduced first. Then a way to transfer the spacecraft to the collinear libration point L3 via the invariant manifolds of the other two collinear libration points was proposed. Theoretical works under the model of circular restricted three-body problem were done. For the sun-earth+moon system, this model is a good approximation. The results obtained are useful when a transfer trajectory under the real solar system is designed.

  4. Width of atomic L2 and L3 vacancy states near Z=30.

    NASA Technical Reports Server (NTRS)

    Yin, L. I.; Adler, I.; Chen, M. H.; Crasemann, B.

    1973-01-01

    Results of an investigation of the discontinuity in the L2 level width and the L3-M45M45/L2-M45M45 Auger intensity ratio at Z=30. The afore-mentioned intensity ratio is found to undergo a sudden decrease at Z=30. Relative L2 and L3 level widths of Cu and Zn are derived from photoelectron spectra; while the L3 width increases from Cu to Zn, the L2 width of Cu is greater than that of Zn, contrary to the general trend. The above-mentioned discontinuity is traced to a discontinuity in the Coster-Kronig transition probability f sub 23 predicted in earlier calculations.

  5. Action of different monoterpenic compounds against Anisakis simplex s.l. L3 larvae.

    PubMed

    Hierro, I; Valero, A; Pérez, P; González, P; Cabo, M M; Montilla, M P; Navarro, M C

    2004-01-01

    Different natural monoterpenes (geraniol, citronellol, citral, carvacrol, cuminaldehyde and eugenol) are studied in vitro against Anisakis simplex s.l. L3 larvae, employing perillaldehyde as a reference substance. Final concentrations used were: 12.50, 6.25 and 3.12 microg/ml for each of the tested products. The parameters average survival, survival 50 and maximum survival were determined at 4, 8, 24 and 48 hours after the start of the experiment. All tested products, except eugenol, were active at the highest concentration (12.50 microg/ml). The damage caused to A. simplex s.l. L3 was by examining histological sections. The antioxidant activity of the tested products by DPPH free radical scavenging does not appear to be associated with their larvicide activity against A. simplex s.l. L3.

  6. Developing consensus-based policy solutions for medicines adherence for Europe: a delphi study

    PubMed Central

    2012-01-01

    Background Non-adherence to prescribed medication is a pervasive problem that can incur serious effects on patients’ health outcomes and well-being, and the availability of resources in healthcare systems. This study aimed to develop practical consensus-based policy solutions to address medicines non-adherence for Europe. Methods A four-round Delphi study was conducted. The Delphi Expert Panel comprised 50 participants from 14 countries and was representative of: patient/carers organisations; healthcare providers and professionals; commissioners and policy makers; academics; and industry representatives. Participants engaged in the study remotely, anonymously and electronically. Participants were invited to respond to open questions about the causes, consequences and solutions to medicines non-adherence. Subsequent rounds refined responses, and sought ratings of the relative importance, and operational and political feasibility of each potential solution to medicines non-adherence. Feedback of individual and group responses was provided to participants after each round. Members of the Delphi Expert Panel and members of the research group participated in a consensus meeting upon completion of the Delphi study to discuss and further refine the proposed policy solutions. Results 43 separate policy solutions to medication non-adherence were agreed by the Panel. 25 policy solutions were prioritised based on composite scores for importance, and operational and political feasibility. Prioritised policy solutions focused on interventions for patients, training for healthcare professionals, and actions to support partnership between patients and healthcare professionals. Few solutions concerned actions by governments, healthcare commissioners, or interventions at the system level. Conclusions Consensus about practical actions necessary to address non-adherence to medicines has been developed for Europe. These actions are also applicable to other regions. Prioritised

  7. Patient safety priorities in mental healthcare in Switzerland: a modified Delphi study

    PubMed Central

    Mascherek, Anna C

    2016-01-01

    Objective Identifying patient safety priorities in mental healthcare is an emerging issue. A variety of aspects of patient safety in medical care apply for patient safety in mental care as well. However, specific aspects may be different as a consequence of special characteristics of patients, setting and treatment. The aim of the present study was to combine knowledge from the field and research and bundle existing initiatives and projects to define patient safety priorities in mental healthcare in Switzerland. The present study draws on national expert panels, namely, round-table discussion and modified Delphi consensus method. Design As preparation for the modified Delphi questionnaire, two round-table discussions and one semistructured questionnaire were conducted. Preparative work was conducted between May 2015 and October 2015. The modified Delphi was conducted to gauge experts' opinion on priorities in patient safety in mental healthcare in Switzerland. In two independent rating rounds, experts made private ratings. The modified Delphi was conducted in winter 2015. Results Nine topics were defined along the treatment pathway: diagnostic errors, non-drug treatment errors, medication errors, errors related to coercive measures, errors related to aggression management against self and others, errors in treatment of suicidal patients, communication errors, errors at interfaces of care and structural errors. Conclusions Patient safety is considered as an important topic of quality in mental healthcare among experts, but it has been seriously neglected up until now. Activities in research and in practice are needed. Structural errors and diagnostics were given highest priority. From the topics identified, some are overlapping with important aspects of patient safety in medical care; however, some core aspects are unique. PMID:27496233

  8. Planning for chemical incidents by implementing a Delphi based consensus study

    PubMed Central

    Crawford, I; Mackway-Jones, K; Russell, D; Carley, S

    2004-01-01

    This paper provides a practical approach to the difficulties surrounding planning for chemical incidents, based upon the results of a Delphi based consensus study. It is intended to offer advice, which can be implemented at regional and local prehospital and hospital level. The phases of the response that are covered include preparation, management of the incident, delivery of medical support during the incident, and recovery and support after the incident. PMID:14734368

  9. Advanced Use of Wolrd-Wide Web in the Online System of Delphi

    NASA Astrophysics Data System (ADS)

    DöNszelmann, M.; Carvalho, D.; Mundim, L. M.; Du, S.; Rodden, K.; TennebØ, F.

    The World-Wide Web technology is used by the DELPHI experiment at CERN to provide easy access to information of the `On-line System'. WWW technology on both client and server side is used in five different projects. The World-Wide Web has its advantages concerning the network technology, the practical user interface and its scalability. It however also demands a stateless protocol and format negotiation.

  10. Development of the Assessment Items of Debris Flow Using the Delphi Method

    NASA Astrophysics Data System (ADS)

    Byun, Yosep; Seong, Joohyun; Kim, Mingi; Park, Kyunghan; Yoon, Hyungkoo

    2016-04-01

    In recent years in Korea, Typhoon and the localized extreme rainfall caused by the abnormal climate has increased. Accordingly, debris flow is becoming one of the most dangerous natural disaster. This study aimed to develop the assessment items which can be used for conducting damage investigation of debris flow. Delphi method was applied to classify the realms of assessment items. As a result, 29 assessment items which can be classified into 6 groups were determined.

  11. The setting of standards for agricultural nitrogen emissions: a case study of the Delphi technique.

    PubMed

    Angus, A J; Hodge, I D; McNally, S; Sutton, M A

    2003-12-01

    The Delphi technique is a means of aggregating the judgement of a panel of experts in order to improve the quality of decision-making. This paper provides a case study of the technique by undertaking a three-round Delphi study to determine a package of best available techniques to reduce nitrogen emissions from a poultry unit under the Integrated Pollution Prevention and Control Directive (IPPC). Forms of nitrogen addressed included ammonia (NH3), nitrous oxide (N2O) nitrogen oxides (NOx), dusts and nitrate (NO3-), with the study providing a means to prioritise the pollution concerns on different spatial scales. The priority pollutant issues were the contribution of NH3 to eutrophication, the global cooling effect of NH4+ aerosol, the role of NH4+ as a vector for atmospheric transport of NOx and SO2, the contribution of N2O to global warming, and NO3- leaching. Reduced nitrogen (NHx) was rated as a priority on all scales, while N2O and NO3- were rated as priorities only on global and local scales, respectively. The study indicated the need for abatement techniques at each stage of poultry rearing and waste management, with particular attention to reduce NH3 emissions, reflecting the priority pollutant concerns. Measures identified by the panel include maintenance of dry litter, low emission removal of litter from housing and storage of litter under cover. Once the litter has left the farm, this should either be used as a biofuel for electricity generation or rapidly incorporated into agricultural soils. The amounts and timing of manure application should be tuned to crop needs. Uncertainties in the Delphi technique limit its suitability as a stand-alone decision making tool. However, the Delphi technique proved useful in identifying priority pollutant issues, areas of agreement, disagreement and where information is lacking. This demonstrates its use when dealing with the complex issues of prioritising pollution issues and abatement approaches.

  12. Single and coupled L3 photonic crystal cavities for cavity-QED experiments

    NASA Astrophysics Data System (ADS)

    Bonato, Cristian; Hagemeier, Jenna; Gerace, Dario; Thon, Susanna M.; Kim, Hyochul; Beirne, Gareth; Bakker, Morten; Andreani, Lucio C.; Petroff, Pierre M.; van Exter, Martin P.; Bouwmeester, Dirk

    2012-06-01

    Here we discuss the experimental characterization of the spatial far-field profiles for the confined modes in a photonic crystal cavity of the L3 type, finding a good agreement with FDTD simulations. We then link the far-field profiles to relevant features of the cavity mode near-fields, using a simple Fabry-Perot resonator model. Finally, we describe a technique for independent all-electrical control of the wavelength of quantum dots in separated L3 cavities, coupled by a waveguide, by electrical isolation via proton implantation

  13. Genetically designed L3 photonic crystal nanocavities with measured quality factor exceeding one million

    SciTech Connect

    Lai, Y.; Badolato, A.; Pirotta, S.; Urbinati, G.; Gerace, D.; Galli, M.; Minkov, M.; Savona, V.

    2014-06-16

    We report on the experimental realization of ultra-high quality factor (Q) designs of the L3-type photonic crystal nanocavity. Based on genetic optimization of the positions of few nearby holes, our design drastically improves the performance of the conventional L3 as experimentally confirmed by direct measurement of Q ≃ 2 × 10{sup 6} in a silicon-based photonic crystal membrane. Our devices rank among the highest Q/V ratios ever reported in photonic crystal cavities, holding great promise for the realization of integrated photonic platforms based on ultra-high-Q resonators.

  14. Use of a Delphi panel to establish consensus for recommended uses of selected balance assessment approaches.

    PubMed

    McGinnis, Patricia Q; Wainwright, Susan F; Hack, Laurita M; Nixon-Cave, Kim; Michlovitz, Susan

    2010-08-01

    The Delphi survey is a useful mechanism to make recommendations for clinical judgments in the absence of practice guidelines for evidence-based decision making. Although there is a great deal of literature about the topic of various methods of balance assessment, decisions about application of research evidence for clinical practice may be subject to personal interpretation and/or biases of the reader. In this study, a panel of informed experts was used through a Delphi process to establish consensus regarding the recommended use of selected balance assessment methods based on the literature. Selective recruitment of experienced faculty members with advanced degrees and/or specialist certification in the content area identified seven knowledgeable informants. The panel participated in three rounds of discussion to develop a consensus-based summary of the recommended use of balance assessment methods commonly used in clinical practice and suggest how those measures fit within the framework of the Patient/Client Management Model of physical therapy practice. The outcomes of the Delphi process form a basis for recommended practice in the examination of patients with balance deficits and serve as a starting point in the development of evidence-based practice guidelines.

  15. A Delphi-matrix approach to SEA and its application within the tourism sector in Taiwan

    SciTech Connect

    Kuo, N.-W. . E-mail: ibis@ntcn.edu.tw; Hsiao, T.-Y.; Yu, Y.-H.

    2005-04-15

    Strategic Environmental Assessment (SEA) is a procedural tool and within the framework of SEA, several different types of analytical methods can be used in the assessment. However, the impact matrix used currently in Taiwan has some disadvantages. Hence, a Delphi-matrix approach to SEA is proposed here to improve the performance of Taiwan's SEA. This new approach is based on the impact matrix combination with indicators of sustainability, and then the Delphi method is employed to collect experts' opinions. In addition, the assessment of National Floriculture Park Plan and Taiwan Flora 2008 Program is taken as an example to examine this new method. Although international exhibition is one of the important tourism (economic) activities, SEA is seldom about tourism sector. Finally, the Delphi-matrix approach to SEA for tourism development plan is established containing eight assessment topics and 26 corresponding categories. In summary, three major types of impacts: resources' usages, pollution emissions, and local cultures change are found. Resources' usages, such as water, electricity, and natural gas demand, are calculated on a per capita basis. Various forms of pollution resulting from this plan, such as air, water, soil, waste, and noise, are also identified.

  16. Anatomical Society core regional anatomy syllabus for undergraduate medicine: the Delphi process.

    PubMed

    Smith, C F; Finn, G M; Stewart, J; McHanwell, S

    2016-01-01

    A modified Delphi method was employed to seek consensus when revising the UK and Ireland's core syllabus for regional anatomy in undergraduate medicine. A Delphi panel was constructed involving 'expert' (individuals with at least 5 years' experience in teaching medical students anatomy at the level required for graduation). The panel (n = 39) was selected and nominated by members of Council and/or the Education Committee of the Anatomical Society and included a range of specialists including surgeons, radiologists and anatomists. The experts were asked in two stages to 'accept', 'reject' or 'modify' (first stage only) each learning outcome. A third stage, which was not part of the Delphi method, then allowed the original authors of the syllabus to make changes either to correct any anatomical errors or to make minor syntax changes. From the original syllabus of 182 learning outcomes, removing the neuroanatomy component (163), 23 learning outcomes (15%) remained unchanged, seven learning outcomes were removed and two new learning outcomes added. The remaining 133 learning outcomes were modified. All learning outcomes on the new core syllabus achieved over 90% acceptance by the panel.

  17. Structural Setting and Upper Quaternary landscape evolution at Delphi, Central Greece

    NASA Astrophysics Data System (ADS)

    Kranis, H.; Skourtsos, E.; Gouliotis, L.; Lozios, S.

    2012-04-01

    We present an alternative view of the active tectonics and landscape evolution of the Delphi archaeological site, located on the southern margin of Mt Parnassos, central Greece, based on detailed geological mapping. The tectonic grain of the area provides the key to understanding the nature and degree of tectonic activity and associated natural hazards in this worldwide famous site, on the northern margin of the Corinth Rift. The dominant structure is a gently north-dipping thrust fault (SPT), which marks the southern boundary of Mt Parnassos. This thrust brings the Mesozoic carbonates over the flysch members of the Parnassos Unit. Intense folding is observed at all scales and the hanging-wall of the thrust corresponds to an overturned anticline, thrusted over the flysch, the latter cropping out along the south-facing mountain slope and the adjacent valley of Pleistos. The hanging-wall block of the SPT is intensely fractured; a dominant set of steep discontinuities, east and west of the archaeological site has facilitated slope failure, with some of them accommodating minor amounts of dip-slip displacement. One of them is identified as an active structure ("Delphi Fault") exposed after road improvement works several years ago. This surface can be mapped for only ~150 m east and 1.3 km west of Delphi: detailed geological mapping showed that it invariably belongs to the hanging-wall of the SPT, which has a total length of ca 25 km. Slope failure processes, which appear to be dominant at least during the Upper Quaternary years have led to the accumulation of sizeable blocks (measuring from 0.2 - 3.5km2) which have slipped on the incompetent, impermeable clastics that form the footwall of the SPT. We therefore suggest that the structure identified as the "Delphi Fault" belongs to a set of subvertical discontinuities which have developed on the culmination of an overturned anticline, on the hanging-wall block of a major thrust fault. This surface is associated with

  18. Establishing key components of yoga interventions for musculoskeletal conditions: a Delphi survey

    PubMed Central

    2014-01-01

    Background Evidence suggests yoga is a safe and effective intervention for the management of physical and psychosocial symptoms associated with musculoskeletal conditions. However, heterogeneity in the components and reporting of clinical yoga trials impedes both the generalization of study results and the replication of study protocols. The aim of this Delphi survey was to address these issues of heterogeneity, by developing a list of recommendations of key components for the design and reporting of yoga interventions for musculoskeletal conditions. Methods Recognised experts involved in the design, conduct, and teaching of yoga for musculoskeletal conditions were identified from a systematic review, and invited to contribute to the Delphi survey. Forty-one of the 58 experts contacted, representing six countries, agreed to participate. A three-round Delphi was conducted via electronic surveys. Round 1 presented an open-ended question, allowing panellists to individually identify components they considered key to the design and reporting of yoga interventions for musculoskeletal conditions. Thematic analysis of Round 1 identified items for quantitative rating in Round 2; items not reaching consensus were forwarded to Round 3 for re-rating. Results Thirty-six panellists (36/41; 88%) completed the three rounds of the Delphi survey. Panellists provided 348 comments to the Round 1 question. These comments were reduced to 49 items, grouped under five themes, for rating in subsequent rounds. A priori group consensus of ≥80% was reached on 28 items related to five themes concerning defining the yoga intervention, types of yoga practices to include in an intervention, delivery of the yoga protocol, domains of outcome measures, and reporting of yoga interventions for musculoskeletal conditions. Additionally, a priori consensus of ≥50% was reached on five items relating to minimum values for intervention parameters. Conclusions Expert consensus has provided a non

  19. Generative Syntactic Transfer in L2 and L3 Acquisition via the Channel of Translation

    ERIC Educational Resources Information Center

    Shooshtari, Zohreh Gooniband

    2009-01-01

    The purpose of this study was two-fold: it primarily intended to incorporate some insights into the newly-explored field of L3A: secondly, it aimed to highlight the significance of translation as a valid language activity in exploring the native language influence on non-native language acquisition process. To this end, it investigated the…

  20. What Variables Condition Syntactic Transfer? A Look at the L3 Initial State

    ERIC Educational Resources Information Center

    Rothman, Jason; Cabrelli Amaro, Jennifer

    2010-01-01

    This study investigates transfer at the third-language (L3) initial state, testing between the following possibilities: (1) the first language (L1) transfer hypothesis (an L1 effect for all adult acquisition), (2) the second language (L2) transfer hypothesis, where the L2 blocks L1 transfer (often referred to in the recent literature as the "L2…

  1. Double Object Constructions in L3 English: An Exploratory Study of Morphological and Semantic Constraints

    ERIC Educational Resources Information Center

    Agirre, Ainara Imaz; García Mayo, María del Pilar

    2014-01-01

    The present study examines the acquisition of double object constructions (DOCs) ("Susan gave Peter an apple") by 90 Basque/Spanish learners of English as a third language (L3). The aim of this study was to explore whether (i) learners established a distinction when accepting DOCs vs. prepositional phrase constructions (PPCs)…

  2. Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion.

    PubMed

    Kraft-Sheleg, Ortal; Zaffryar-Eilot, Shelly; Genin, Olga; Yaseen, Wesal; Soueid-Baumgarten, Sharon; Kessler, Ofra; Smolkin, Tatyana; Akiri, Gal; Neufeld, Gera; Cinnamon, Yuval; Hasson, Peleg

    2016-03-01

    For muscles to function, myofibers have to stretch and anchor at the myotendinous junction (MTJ), a region rich in extracellular matrix (ECM). Integrin signaling is required for MTJ formation, and mutations affecting the cascade lead to muscular dystrophies in mice and humans. Underlying mechanisms for integrin activation at the MTJ and ECM modifications regulating its signaling are unclear. We show that lysyl oxidase-like 3 (LoxL3) is a key regulator of integrin signaling that ensures localized control of the cascade. In LoxL3 mutants, myofibers anchor prematurely or overshoot to adjacent somites, and are loose and lack tension. We find that LoxL3 complexes with and directly oxidizes Fibronectin (FN), an ECM scaffold protein and integrin ligand enriched at the MTJ. We identify a mechanism whereby localized LoxL3 secretion from myofiber termini oxidizes FN, enabling enhanced integrin activation at the tips of myofibers and ensuring correct positioning and anchoring of myofibers along the MTJ. PMID:26954549

  3. Inter- and Intralingual Lexical Influences in Advanced Learners' French L3 Oral Production

    ERIC Educational Resources Information Center

    Lindqvist, Christina

    2010-01-01

    The present study investigates lexical inter- and intralingual influences in the oral production of 14 very advanced learners of French L3. Lexical deviances are divided into two main categories: formal influence and meaning-based influence. The results show that, as predicted with respect to advanced learners, meaning-based influence is the most…

  4. L1/L2/L3 Writing Development: Longitudinal Case Study of a Japanese Multicompetent Writer

    ERIC Educational Resources Information Center

    Kobayashi, Hiroe; Rinnert, Carol

    2013-01-01

    This longitudinal case study, supplemented by cross-sectional comparisons among five groups of writers with differing backgrounds, investigates how Natsu, a Japanese multilingual writer, developed her L1, L2 (English), and L3 (Chinese) writing competence over two and a half years. To create a comprehensive picture of this multilingual writer, the…

  5. An Experimental Study of Early L3 Development: Age, Bilingualism and Classroom Exposure

    ERIC Educational Resources Information Center

    Stafford, Catherine A.; Sanz, Cristina; Bowden, Harriet Wood

    2010-01-01

    This research investigated Spanish-English bilingual adults' initial learning of a third language (L3), Latin, comparing the learning processes and outcomes of early- and late-onset bilinguals. Thirty-three participants were classified as Early or Late Bilinguals according to their age of arrival to the USA, and they were introduced to Latin by…

  6. Epb41l3 suppresses esophageal squamous cell carcinoma invasion and inhibits MMP2 and MMP9 expression.

    PubMed

    Zeng, Rong; Huang, Jun-Peng; Li, Xu Feng; Xiong, Wei-Bin; Wu, Gang; Jiang, Zhao-Jing; Song, Shu-Jie; Li, Ji-Qiang; Zheng, Yan-Fang; Zhang, Ji-Ren

    2016-04-01

    EPB41L3 may play a role as a metastasis suppressor by supporting regular arrangements of actin stress fibres and alleviating the increase in cell motility associated with enhanced metastatic potential. Downregulation of epb41l3 has been observed in many cancers, but the role of this gene in esophageal squamous cell carcinoma (ESCC) remains unclear. Our study aimed to determine the effect of epb41l3 on ESCC cell migration and invasion. We investigated epb41l3 protein expression in tumour and non-tumour tissues by immunohistochemical staining. Expression in the non-neoplastic human esophageal cell line Het-1a and four ESCC cell lines - Kyse150, Kyse510, Kyse450 and Caes17 - was assessed by quantitative Polymerase Chain Reaction (qPCR) and Western blotting. Furthermore, an EPB41L3 overexpression plasmid and EPB41L3-specific small interfering RNA were used to upregulate EPB41L3 expression in Kyse150 cells and to downregulate EPB41L3 expression in Kyse450 cells, respectively. Cell migration and invasion were evaluated by wound healing and transwell assays, respectively. The expression levels of p-AKT, matrix metalloproteinase (MMP)2 and MMP9 were evaluated. Expression of epb41l3 was significantly lower in tumour tissues than in non-tumour tissues and in ESCC cell lines compared with the Het-1a cell line. Kyse450 and Caes17 cells exhibited higher expression of epb41l3 than Kyse150 and Kyse510 cells. Overexpressing epb41l3 decreased Kyse150 cell migration and invasion, whereas EPB41L3-specific small interfering RNA silencing increased these functions in Kyse450 cells. Furthermore, overexpressing epb41l3 led to downregulation of MMP2 and MMP9 in Kyse150 and Kyse510 cells. Our findings reveal that EPB41L3 suppresses tumour cell invasion and inhibits MMP2 and MMP9 expression in ESCC cells.

  7. DelPhi web server v2: incorporating atomic-style geometrical figures into the computational protocol

    PubMed Central

    Smith, Nicholas; Witham, Shawn; Sarkar, Subhra; Zhang, Jie; Li, Lin; Li, Chuan; Alexov, Emil

    2012-01-01

    Summary: A new edition of the DelPhi web server, DelPhi web server v2, is released to include atomic presentation of geometrical figures. These geometrical objects can be used to model nano-size objects together with real biological macromolecules. The position and size of the object can be manipulated by the user in real time until desired results are achieved. The server fixes structural defects, adds hydrogen atoms and calculates electrostatic energies and the corresponding electrostatic potential and ionic distributions. Availability and implementation: The web server follows a client–server architecture built on PHP and HTML and utilizes DelPhi software. The computation is carried out on supercomputer cluster and results are given back to the user via http protocol, including the ability to visualize the structure and corresponding electrostatic potential via Jmol implementation. The DelPhi web server is available from http://compbio.clemson.edu/delphi_webserver. Contact: nsmith@clemson.edu, ealexov@clemson.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:22531215

  8. A Research Study Using the Delphi Method to Define Essential Competencies for a High School Game Art and Design Course Framework at the National Level

    ERIC Educational Resources Information Center

    Mack, Nayo Corenus-Geneva

    2011-01-01

    This research study reports the findings of a Delphi study conducted to determine the essential competencies and objectives for a high school Game Art and Design course framework at the national level. The Delphi panel consisted of gaming, industry and educational experts from all over the world who were members of the International Game…

  9. Determining the Essential Components of State and Institution Dual Credit Program Policy in New Mexico: A Delphi Study with High School and College Experts

    ERIC Educational Resources Information Center

    Carlson, Gregory Dean

    2013-01-01

    The purpose of this Delphi study was to determine the essential components of dual credit in New Mexico. Dual credit experts from colleges and high schools in New Mexico were asked to participate in a three-round Delphi study to determine what the future policy of dual credit should be, and why it should be that way. Definitions of dual credit may…

  10. Using the Internet to Improve HRD Research: The Case of the Web-Based Delphi Research Technique to Achieve Content Validity of an HRD-Oriented Measurement

    ERIC Educational Resources Information Center

    Hatcher, Tim; Colton, Sharon

    2007-01-01

    Purpose: The purpose of this article is to highlight the results of the online Delphi research project; in particular the procedures used to establish an online and innovative process of content validation and obtaining "rich" and descriptive information using the internet and current e-learning technologies. The online Delphi was proven to be an…

  11. Revising the worksheet with L3: a language and environment foruser-script interaction

    SciTech Connect

    Hohn, Michael H.

    2008-01-22

    This paper describes a novel approach to the parameter anddata handling issues commonly found in experimental scientific computingand scripting in general. The approach is based on the familiarcombination of scripting language and user interface, but using alanguage expressly designed for user interaction and convenience. The L3language combines programming facilities of procedural and functionallanguages with the persistence and need-based evaluation of data flowlanguages. It is implemented in Python, has access to all Pythonlibraries, and retains almost complete source code compatibility to allowsimple movement of code between the languages. The worksheet interfaceuses metadata produced by L3 to provide selection of values through thescriptit self and allow users to dynamically evolve scripts withoutre-running the prior versions. Scripts can be edited via text editors ormanipulated as structures on a drawing canvas. Computed values are validscripts and can be used further in other scripts via simplecopy-and-paste operations. The implementation is freely available underan open-source license.

  12. L1, L2, and L3 subshell fluorescence yields: Updated database and new empirical values

    NASA Astrophysics Data System (ADS)

    Sahnoune, Y.; Kahoul, A.; Kasri, Y.; Deghfel, B.; Medjadi, D. E.; Khalfallah, F.; Daoudi, S.; Aylikçi, V.; Küp Aylikçi, N.; Nekkab, M.

    2016-08-01

    In this paper, a summary of experimental data published in the period of time between 1955 to february-2016 was presented in a tabular form for Li subshell fluorescence yields (ωL1 ,ωL2 andωL3) taken from different sources. First, a critical examination of these data using the weighted average valuesωLi-W was presented. Then, an interpolation using the famous analytical function (ωLi-W / (1 -ωLi-W)) 1 / 4 vs the atomic number Z was proformed to deduce a new empirical Li subshell fluorescence yields for elements in the range 40≤Z≤96 for ωL1 and ωL2 and 23≤Z≤96 for ωL3 . At last, our calculated empirical Li subshell fluorescence yields have been compared with other theoretical and empirical values reported in the literature.

  13. Operationalizing the TANIC and NICA-L3/L4 Tools to Improve Informatics Competencies.

    PubMed

    Sipes, Carolyn; McGonigle, Dee; Hunter, Kathy; Hebda, Toni; Hill, Taryn; Lamblin, Jean

    2016-01-01

    Two tools were developed for nurses to self-assess different levels of informatics competencies. The TANIC is used for all nurses to self-assess; the NICA-L3/L4 is a tool for the informatics nurse specialist (INS) to self-assess skill levels. There are 167 informatics items in the TANIC and 178 advanced informatics items in the NICA-L3/L4. These tools were piloted; the results presented here. Based on the evaluation, the tools have been integrated into informatics courses at the BSN and MSN programs at Chamberlain College of Nursing, and presented in two AACN webinars and other national conferences. Numerous requests have been honored to provide the tools for other schools of nursing to use in their courses, including DNP programs. Other requests include those from CNIOs and managers to include in their job descriptions for informatics nurses. PMID:27332209

  14. Astronomical imaging with L3CCDs: detector performance and high-speed controller design

    NASA Astrophysics Data System (ADS)

    Mackay, Craig; Basden, Alistair; Bridgeland, Mick

    2004-09-01

    L3CCDs represent a major step in CCD performance with great potential for astronomical applications because of their ability to work at very high pixel rates with negligible readout noise. This paper describes the results of tests on some of the L3CCDs now available and discusses how the operating conditions may be optimised for a variety of different applications. In particular, at high gain they can be used for photon counting work at photon rates well in excess of one photon per pixel per second. Readout rates which can be as high as 35MHz are entirely practical for a number of astronomical applications. This paper describes some of the compromises and trade-offs that have to be made in designing high-speed controllers to work effectively with these devices. The importance of integrating high-speed controllers for astronomy with significant amount of real-time processing power is also discussed.

  15. Large High Performance Optics for Spaceborne Missions: L-3 Brashear Experience and Capability

    NASA Technical Reports Server (NTRS)

    Canzian, Blaise; Gardopee, George; Clarkson, Andrew; Hull, Tony; Borucki, William J.

    2010-01-01

    Brashear is a division of L-3 Communications, Integrated Optical Systems. Brashear is well known for the ground-based telescopes it has manufactured at its facilities and delivered to satisfied customers. Optics from meter-class up to 8.3 meters diameter have been fabricated in Brashear's facilities. Brashear has demonstrated capabilities for large spaceborne optics. We describe in this paper both legacy and new Brashear capabilities for high performance spaceborne optics.

  16. In vivo Loads in the Lumbar L3-4 Disc during a Weight Lifting Extension

    PubMed Central

    Wang, Shaobai; Park, Won Man; Kim, Yoon Hyuk; Cha, Thomas; Wood, Kirkham; Li, Guoan

    2014-01-01

    Background Knowledge of in vivo human lumbar loading is critical for understanding the lumbar function and for improving surgical treatments of lumbar pathology. Although numerous experimental measurements and computational simulations have been reported, non-invasive determination of in vivo spinal disc loads is still a challenge in biomedical engineering. The object of the study is to investigate the in vivo human lumbar disc loads using a subject-specific and kinematic driven finite element approach. Methods Three dimensional (3D) lumbar spine models of three living subjects were created using MR images. A 3D finite element model of the L3-4 disc, including the annulus fibrosus and nucleus pulposus, was built for each subject. The endplate kinematics of the L3-4 segment of each subject during a dynamic weight lifting extension was determined using a dual fluoroscopic imaging technique. The endplate kinematics was used as displacement boundary conditions of the subject specific finite element model of the L3-4 disc to calculate the in-vivo disc forces and moments during the weight lifting activity. Findings During the weight lifting extension, the L3-4 disc experienced maximum shear load of about 230 N or 0.34 bodyweight at the flexion position and maximum compressive load of 1500 N or 2.28 bodyweight at the upright position. The disc experienced a primary flexion-extension moment during the motion which reached a maximum of 4.2 Nm at upright position with stretched arms holding the weight. Interpretation This study provided quantitative data on in vivo disc loading that could help understand intrinsic biomechanics of the spine and improve surgical treatment of pathological discs using fusion or arthroplasty techniques. PMID:24345591

  17. Probing magnetostructural correlations in multiferroic HoA l3(BO3) 4

    NASA Astrophysics Data System (ADS)

    Zhang, H.; Yu, T.; Chen, Z.; Nelson, C. S.; Bezmaternykh, L. N.; Abeykoon, A. M. M.; Tyson, T. A.

    2015-09-01

    The system HoA l3(BO3) 4 has recently been found to exhibit a large magnetoelectric effect. To understand the mechanism, macroscopic and atomic level properties of HoA l3(BO3) 4 were explored by temperature and magnetic field dependent heat capacity measurements, pressure and temperature dependent x-ray diffraction measurements, as well as temperature and magnetic field dependent x-ray absorption fine structure measurements. The experimental work was complemented by density functional theory calculations. An anomalous change in the structure is found in the temperature range where large magnetoelectric effects occur. No significant structural change or distortion of the Ho O6 polyhedra is seen to occur with magnetic field. However, the magnetic field dependent structural measurements reveal enhanced correlation between neighboring Ho O6 polyhedra. This observed response is seen to saturate near 3 T. A qualitative atomic level description of the mechanism behind the large electric polarization induced by magnetic fields in the general class of RA l3(BO3) 4 systems (R = rare earth) is developed.

  18. Cognition and Mood-Related Behaviors in L3mbtl1 Null Mutant Mice

    PubMed Central

    Shen, Erica Y.; Jiang, Yan; Mao, Wenjie; Futai, Kensuke; Hock, Hanno; Akbarian, Schahram

    2015-01-01

    Alterations in histone lysine methylation and epigenetic regulators of gene expression could play a role in the neurobiology and treatment of patients diagnosed with mood spectrum disorder, including depression and anxiety. Mutations and altered expression of various lysine methyltransferases (KMTs) and demethylases (KDMs) have been linked to changes in motivational and emotional behaviors in preclinical model systems. However, it is not known whether regulators operating downstream of histone lysine methylation could affect mood-related behavior. Malignant Brain Tumor (MBT) domain ‘chromatin reader’ proteins bind to methylated histone lysine residues and associate with chromatin remodeling complexes to facilitate or repress gene expression. MBT proteins, including the founding member, L3mbtl1, maintain high levels of expression in neurons of the mature brain. Here, we exposed L3mbtl1 null mutant mice to a wide range of tests exploring cognition and mood-relevant behaviors at baseline and in the context of social isolation, as a stressor to elicit depression-related behavior in susceptible mice. L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms. This was not associated with a more generalized neurological dysfunction because cognition and memory remained unaltered in comparison to controls. These findings warrant further investigations on the role of MBT chromatin reader proteins in the context of emotional and affective behaviors. PMID:25849281

  19. A DELPHI STUDY OF RISK FACTORS FOR ACHILLES TENDINOPATHY- OPINIONS OF WORLD TENDON EXPERTS

    PubMed Central

    Watson, Paul J.; Barry, Simon

    2016-01-01

    Background and Purpose Achilles tendinopathy can be a debilitating chronic condition for both active and inactive individuals. The identification of risk facors is important both in preventing but also treating tendinopathy, many factors have been proposed but there is a lack of primary epidemiological data. The purpose of this study was to develop a statement of expert consensus on risk factors for Achilles tendinopathy in active and sedentary patient populations to inform a primary epidemiological study. Study design Delphi study Methods and Measures An online Delphi study was completed inviting participation from world tendon experts. The consensus was developed using three rounds of the Delphi technique. The first round developed a complete list of potential risk factors, the second round refined this list but also separated the factors into two population groups – active/athletic and inactive/sedentary. The third round ranked this list in order of perceived importance. Results Forty-four experts were invited to participate, 16 participated in the first round (response rate 40%) and two dropped out in the second round (resulting in a response rate of 35%). A total of 27 intrinsic and eight extrinsic risk factors were identified during round one. During round two only 12 intrinsic and five extrinsic risk factors were identified as important in active/athletic tendinopathy while 14 intrinsic and three extrinsic factors were identified as important for inactive/sedentary tendinopathy. Conclusions Risk factors for Achilles tendinopathy were identified based on expert consensus, and these factors provide a basis for primary epidemiological studies. Plantarflexor strength was identified as the primary modifiable factor in the active/athletic group while systemic factors were identified as important in the inactive/sedentary group, many of the potential factors suggested for either group were non-modifiable. Non-modifiable factors include: previous tendinopathy

  20. Designing Excellence and Quality Model for Training Centers of Primary Health Care: A Delphi Method Study

    PubMed Central

    TABRIZI, Jafar-Sadegh; FARAHBAKHSH, Mostafa; SHAHGOLI, Javad; RAHBAR, Mohammad Reza; NAGHAVI-BEHZAD, Mohammad; AHADI, Hamid-Reza; AZAMI-AGHDASH, Saber

    2015-01-01

    Background: Excellence and quality models are comprehensive methods for improving the quality of healthcare. The aim of this study was to design excellence and quality model for training centers of primary health care using Delphi method. Methods: In this study, Delphi method was used. First, comprehensive information were collected using literature review. In extracted references, 39 models were identified from 34 countries and related sub-criteria and standards were extracted from 34 models (from primary 39 models). Then primary pattern including 8 criteria, 55 sub-criteria, and 236 standards was developed as a Delphi questionnaire and evaluated in four stages by 9 specialists of health care system in Tabriz and 50 specialists from all around the country. Results: Designed primary model (8 criteria, 55 sub-criteria, and 236 standards) were concluded with 8 criteria, 45 sub-criteria, and 192 standards after 4 stages of evaluations by specialists. Major criteria of the model are leadership, strategic and operational planning, resource management, information analysis, human resources management, process management, costumer results, and functional results, where the top score was assigned as 1000 by specialists. Functional results had the maximum score of 195 whereas planning had the minimum score of 60. Furthermore the most and the least sub-criteria was for leadership with 10 sub-criteria and strategic planning with 3 sub-criteria, respectively. Conclusion: The model that introduced in this research has been designed following 34 reference models of the world. This model could provide a proper frame for managers of health system in improving quality. PMID:26576350

  1. Stereoselective L-[3H]quinuclidinyl benzilate-binding sites in nervous tissue of Aplysia californica: evidence for muscarinic receptors.

    PubMed

    Murray, T F; Mpitsos, G J; Siebenaller, J F; Barker, D L

    1985-12-01

    The muscarinic antagonist L-[3H]quinuclidinyl benzilate (L-[3H]QNB) binds with a high affinity (Kd = 0.77 nM) to a single population of specific sites (Bmax = 47 fmol/mg of protein) in nervous tissue of the gastropod mollusc, Aplysia. The specific L-[3H]QNB binding is displaced stereoselectively by the enantiomers of benzetimide, dexetimide, and levetimide. The pharmacologically active enantiomer, dexetimide, is more potent than levetimide as an inhibitor of L-[3H]QNB binding. Moreover, the muscarinic cholinergic ligands, scopolamine, atropine, oxotremorine, and pilocarpine are effective inhibitors of the specific L-[3H]QNB binding, whereas nicotinic receptor antagonists, decamethonium and d-tubocurarine, are considerably less effective. These pharmacological characteristics of the L-[3H]QNB-binding site provide evidence for classical muscarinic receptors in Aplysia nervous tissue. The physiological relevance of the dexetimide-displaceable L-[3H]QNB-binding site was supported by the demonstration of the sensitivity of the specific binding to thermal denaturation. Specific binding of L-[3H]QNB was also detected in nervous tissue of another marine gastropod, Pleurobranchaea californica. The characteristics of the Aplysia L-[3H]QNB-binding site are in accordance with studies of numerous vertebrate and invertebrate tissues indicating that the muscarinic cholinergic receptor site has been highly conserved through evolution. PMID:4078624

  2. Pulmonary angiomatosis and hemangioma in common dolphins (Delphinus delphis) stranded in Canary Islands.

    PubMed

    Díaz-Delgado, Josué; Arbelo, Manuel; Sacchini, Simona; Quesada-Canales, Óscar; Andrada, Marisa; Rivero, Miguel; Fernández, Antonio

    2012-08-01

    Vascular tumors and disorders, like angiomatosis, are rarely described in cetacean species. A retrospective histological study was carried out on lung samples from 35 common dolphins (Delphinus delphis) stranded in the Canary Islands coasts looking for morphological vascular changes and likely related causes. Twenty-five out of thirty-five (71%) common dolphins showed focal or multifocal angiomatosis-like lesions. A high association between this type of vascular proliferation and parasitic infestation was observed. In addition, a single pulmonary cavernous hemangioma not previously reported in common dolphins is presented.

  3. Primary central nervous system T-cell lymphoma in a common dolphin (Delphinus delphis).

    PubMed

    Arbelo, M; Espinosa de los Monteros, A; Herráez, P; Suárez-Bonnet, A; Andrada, M; Rivero, M; Grau-Bassas, E R; Fernández, A

    2014-01-01

    This report describes the pathological findings in an adult female short-beaked common dolphin (Delphinus delphis) stranded alive in the Canary Islands. Necropsy examination revealed the presence of a nodular neoplastic growth in the central nervous system (CNS) at the level of the thalamus. Microscopical examination revealed the mass to be a lymphoma and immunohistochemical labelling demonstrated a T-cell origin. No significant lesions were observed in other organs, including lymphoid organs. This is the first report of a primary T-cell lymphoma in the CNS in cetaceans. PMID:24650893

  4. Cost estimation: An expert-opinion approach. [cost analysis of research projects using the Delphi method (forecasting)

    NASA Technical Reports Server (NTRS)

    Buffalano, C.; Fogleman, S.; Gielecki, M.

    1976-01-01

    A methodology is outlined which can be used to estimate the costs of research and development projects. The approach uses the Delphi technique a method developed by the Rand Corporation for systematically eliciting and evaluating group judgments in an objective manner. The use of the Delphi allows for the integration of expert opinion into the cost-estimating process in a consistent and rigorous fashion. This approach can also signal potential cost-problem areas. This result can be a useful tool in planning additional cost analysis or in estimating contingency funds. A Monte Carlo approach is also examined.

  5. Evaluation dimensions for collaborative mental health services in primary care systems in latin america: results of a Delphi group.

    PubMed

    Sapag, Jaime C; Rush, Brian; Barnsley, Jan

    2015-05-01

    This article presents the results of a Delphi group to identify the dimensions of an evaluation framework for collaborative mental health care (CMHC) in Latin America. A three-round Delphi process was implemented with 26 experts from Latin America and Canada to identify main areas of consensus, as well as disagreements, about the importance and feasibility of potential evaluation dimensions previously identified in Mexico, Nicaragua and Chile. Participants validated 40 evaluation dimensions. They strongly endorsed a comprehensive evaluation framework for CMHC in Latin America. This study represents a solid foundation for developing an evaluation framework for CMHC. PMID:24961356

  6. Cross-Linguistic Influence in Third Language Perception: L2 and L3 Perception of Japanese Contrasts

    ERIC Educational Resources Information Center

    Onishi, Hiromi

    2013-01-01

    This dissertation examines the possible influence of language learners' second language (L2) on their perception of phonological contrasts in their third language (L3). Previous studies on Third Language Acquisition (TLA) suggest various factors as possible sources of cross-linguistic influence in the acquisition of an L3. This dissertation…

  7. The Development of Suppletive and Affixal Tense and Agreement Morphemes in the L3 English of Basque-Spanish Bilinguals

    ERIC Educational Resources Information Center

    Garcia Mayo, Maria del Pilar; Villarreal Olaizola, Izaskun

    2011-01-01

    This article examines the third language (L3) developing morphology of 78 Basque-Spanish bilinguals following a Content and Language Integrated Learning (CLIL) program and a mainstream English as a foreign language (non-CLIL) program. The analysis of cross-sectional and longitudinal oral data shows that (1) the omission of inflection in the L3

  8. Clitics and Object Expression in the L3 Acquisition of Brazilian Portuguese: Structural Similarity Matters for Transfer

    ERIC Educational Resources Information Center

    Montrul, Silvina; Dias, Rejanes; Santos, Helade

    2011-01-01

    This article addresses the role of previously acquired languages in the acquisition of a third language (L3) in two experimental studies on object expression in Brazilian Portuguese (BP). Participants were English-speaking learners of BP as L3 with knowledge of Spanish as a second language (L2) and Spanish-speaking learners of BP with knowledge of…

  9. Strategies to promote better research on oral health in Africa: A Delphi consensus study

    PubMed Central

    Kanoute, Aïda; Faye, Daouda; Bourgeois, Denis

    2014-01-01

    Background: Research on oral health contributes to improved health outcomes; it is an indispensable tool in health policy. But how to fill the gaps in research oral health and to strengthen its capacity is the question. The main objective of the present study is to identify the current status of oral health research and potential strategies, thereby strengthening the research infrastructure and capacity. Delphi consultation, in the perspective of assisting decision-makers to identify strategies to promote better research on oral health in Africa, was initiated. Design and Methods: The panels of 30 experts were asked to complete the questionnaire with 42 items into four groups by web survey. Each indicator statement was considered to be in consensus if the expert's opinion rating was of “A or B” for more than 75% in a scale of seven categories. Quantitative analysis was made from the answers of Delphi round. Results: There was a strong consensus about three items concerning the role of oral health research, the development of research policy for oral health going through an effective governance of research institutes, migration of researchers and fund raising. Conclusion: This study shows strong many dispersal opinions by experts, but highlights the need for to improve the effectiveness of oral health research capacity strengthening activities. Africa's researchers, policy makers and partners will have to give special attention to ensuring that knowledge generated from oral health research is acted on to improve health for all. PMID:24808689

  10. Research Priorities for NCD Prevention and Climate Change: An International Delphi Survey.

    PubMed

    Colagiuri, Ruth; Boylan, Sinead; Morrice, Emily

    2015-10-01

    Climate change and non-communicable diseases (NCDs) are arguably the greatest global challenges of the 21st Century. However, the confluence between them remains under-examined and there is little evidence of a comprehensive, systematic approach to identifying research priorities to mitigate their joint impact. Consequently, we: (i) convened a workshop of academics (n = 25) from the Worldwide Universities Network to identify priority areas at the interface between NCDs and climate change; (ii) conducted a Delphi survey of international opinion leaders in public health and relevant other disciplines; and (iii) convened an expert panel to review and advise on final priorities. Three research areas (water security; transport; conceptualising NCD harms to support policy formation) were listed among the top 10 priorities by >90% of Delphi respondents, and ranked among the top 12 priorities by >60% of respondents who ranked the order of priority. A fourth area (reducing the carbon footprint of cities) was ranked highest by the same >60% of respondents. Our results are consistent with existing frameworks on health and climate change, and extends them by focusing specifically on NCDs. Researching these priorities could progress understanding of climate change and NCDs, and inform global and national policy decisions for mitigating associated harms. PMID:26501301

  11. Research Priorities for NCD Prevention and Climate Change: An International Delphi Survey

    PubMed Central

    Colagiuri, Ruth; Boylan, Sinead; Morrice, Emily

    2015-01-01

    Climate change and non-communicable diseases (NCDs) are arguably the greatest global challenges of the 21st Century. However, the confluence between them remains under-examined and there is little evidence of a comprehensive, systematic approach to identifying research priorities to mitigate their joint impact. Consequently, we: (i) convened a workshop of academics (n = 25) from the Worldwide Universities Network to identify priority areas at the interface between NCDs and climate change; (ii) conducted a Delphi survey of international opinion leaders in public health and relevant other disciplines; and (iii) convened an expert panel to review and advise on final priorities. Three research areas (water security; transport; conceptualising NCD harms to support policy formation) were listed among the top 10 priorities by >90% of Delphi respondents, and ranked among the top 12 priorities by >60% of respondents who ranked the order of priority. A fourth area (reducing the carbon footprint of cities) was ranked highest by the same >60% of respondents. Our results are consistent with existing frameworks on health and climate change, and extends them by focusing specifically on NCDs. Researching these priorities could progress understanding of climate change and NCDs, and inform global and national policy decisions for mitigating associated harms. PMID:26501301

  12. Refining compliance surveys to measure the smokefree status of jurisdictions using the Delphi method

    PubMed Central

    Kumar, R.; Lal, P.; Sharma, D.; Singh, R. J.

    2013-01-01

    Setting: Compliance assessment surveys are cost-effective means of assessing smokefree status in a jurisdiction. Assigning weights to assessment criteria (indicators) can also inform law implementers and policy makers about the effectiveness of the enforcement of smokefree rules. Objective: To develop a standardised measure for compliance surveys using the Delphi method in India. Design: Tobacco control experts from India comprising different constituencies and jurisdictions met for a half-day workshop in August 2012 to deliberate on how weights can be assigned to criteria for smokefree status. Using the Delphi method, the relevance and ranking of criteria from an existing protocol for measuring compliance was evaluated. Results: Consensus was reached on all five compliance survey indicators through three rigorous rounds of discussion. The highest priority was assigned to the absence of the act of smoking in public places (33%), followed by the display of no-smoking signage in public places (32%), absence of cigarette butts or bidi stubs (15%), absence of smoking aids (10%) and absence of tobacco smoke and ash (10%). Conclusion: Tobacco control advocates can effectively inform local policy makers using weights that prioritise directed enforcement and targeted interventions, which in turn will ensure stronger compliance and sustainable smokefree settings. PMID:26393059

  13. Guidelines for using the Delphi Technique to develop habitat suitability index curves

    USGS Publications Warehouse

    Crance, Johnie H.

    1987-01-01

    Habitat Suitability Index (SI) curves are one method of presenting species habitat suitability criteria. The curves are often used with the Habitat Evaluation Procedures (HEP) and are necessary components of the Instream Flow Incremental Methodology (IFIM) (Armour et al. 1984). Bovee (1986) described three categories of SI curves or habitat suitability criteria based on the procedures and data used to develop the criteria. Category I curves are based on professional judgment, with 1ittle or no empirical data. Both Category II (utilization criteria) and Category III (preference criteria) curves have as their source data collected at locations where target species are observed or collected. Having Category II and Category III curves for all species of concern would be ideal. In reality, no SI curves are available for many species, and SI curves that require intensive field sampling often cannot be developed under prevailing constraints on time and costs. One alternative under these circumstances is the development and interim use of SI curves based on expert opinion. The Delphi technique (Pill 1971; Delbecq et al. 1975; Linstone and Turoff 1975) is one method used for combining the knowledge and opinions of a group of experts. The purpose of this report is to describe how the Delphi technique may be used to develop expert-opinion-based SI curves.

  14. Identifying Ethical Issues in Mental Health Research with Minors Adolescents: Results of a Delphi Study.

    PubMed

    Hiriscau, Elisabeta Ioana; Stingelin-Giles, Nicola; Wasserman, Danuta; Reiter-Theil, Stella

    2016-01-01

    Research with minors, especially for preventive purposes, e.g., suicide prevention, investigating risk or self-destructive behaviors such as deviance, drug abuse, or suicidal behavior, is ethically sensitive. We present a Delphi study exploring the ethical implications of the needs formulated by researchers in an international pre-conference who would benefit from ethics support and guidance in conducting Mental Health Research with minors. The resulting List of Ethical Issues (LEI) was submitted to a 2-rounds Delphi process via the Internet, including 34 multidisciplinary experts. In the first round, the experts reviewed the LEI and completed a questionnaire. Results from this round were analyzed and grouped in nine categories comprising 40 items. In the second round, the experts had to agree/disagree with the needs expressed in the LEI leading to a final list of 25 ethical issues considered relevant for Mental Health Research with minors such as: confidentiality of the sensitive data, competence for consenting alone and risk of harm and stigma related to the methodology used in research. It was shown that studies like SEYLE (Saving and Empowering Young Lives in Europe) trigger among researchers wishes to obtain specific recommendations helping to comply with standards for good practice in conducting research with minors. PMID:27187425

  15. Alternative method of highway traffic safety analysis for developing countries using delphi technique and Bayesian network.

    PubMed

    Mbakwe, Anthony C; Saka, Anthony A; Choi, Keechoo; Lee, Young-Jae

    2016-08-01

    Highway traffic accidents all over the world result in more than 1.3 million fatalities annually. An alarming number of these fatalities occurs in developing countries. There are many risk factors that are associated with frequent accidents, heavy loss of lives, and property damage in developing countries. Unfortunately, poor record keeping practices are very difficult obstacle to overcome in striving to obtain a near accurate casualty and safety data. In light of the fact that there are numerous accident causes, any attempts to curb the escalating death and injury rates in developing countries must include the identification of the primary accident causes. This paper, therefore, seeks to show that the Delphi Technique is a suitable alternative method that can be exploited in generating highway traffic accident data through which the major accident causes can be identified. In order to authenticate the technique used, Korea, a country that underwent similar problems when it was in its early stages of development in addition to the availability of excellent highway safety records in its database, is chosen and utilized for this purpose. Validation of the methodology confirms the technique is suitable for application in developing countries. Furthermore, the Delphi Technique, in combination with the Bayesian Network Model, is utilized in modeling highway traffic accidents and forecasting accident rates in the countries of research.

  16. Research Priorities for NCD Prevention and Climate Change: An International Delphi Survey.

    PubMed

    Colagiuri, Ruth; Boylan, Sinead; Morrice, Emily

    2015-10-16

    Climate change and non-communicable diseases (NCDs) are arguably the greatest global challenges of the 21st Century. However, the confluence between them remains under-examined and there is little evidence of a comprehensive, systematic approach to identifying research priorities to mitigate their joint impact. Consequently, we: (i) convened a workshop of academics (n = 25) from the Worldwide Universities Network to identify priority areas at the interface between NCDs and climate change; (ii) conducted a Delphi survey of international opinion leaders in public health and relevant other disciplines; and (iii) convened an expert panel to review and advise on final priorities. Three research areas (water security; transport; conceptualising NCD harms to support policy formation) were listed among the top 10 priorities by >90% of Delphi respondents, and ranked among the top 12 priorities by >60% of respondents who ranked the order of priority. A fourth area (reducing the carbon footprint of cities) was ranked highest by the same >60% of respondents. Our results are consistent with existing frameworks on health and climate change, and extends them by focusing specifically on NCDs. Researching these priorities could progress understanding of climate change and NCDs, and inform global and national policy decisions for mitigating associated harms.

  17. TCM Pattern Questionnaire for Lateral Elbow Pain: Development of an Instrument via a Delphi Process.

    PubMed

    Gadau, Marcus; Zhang, Shi-Ping; Yeung, Wing-Fai; Bian, Zhao-Xiang; Lu, Ai-Ping

    2016-01-01

    Individualized acupuncture treatment has been practiced for pain therapy. This study used acupuncture treatment for lateral elbow pain (LEP) as an example to study the diagnostic practice of individualized acupuncture treatment. A provisional version of LEP pattern questionnaire was developed based on a recent systematic review on TCM pattern diagnosis for LEP. A Delphi panel of 33 clinical experts from seven different countries was formed, and the Delphi survey was conducted in Chinese and English language for two rounds. Consensus was achieved from all 26 panelists who responded to the second round on 243 items of the instrument, which included a 72-question-long questionnaire. The mean level of expert consensus on the items of the final questionnaire was 85%. Consensus was found on four TCM patterns that could underlie LEP, namely, the wind-cold-dampness pattern, the qi stagnation and blood stasis pattern, the dual deficiency of qi and blood pattern, and the retained dampness-heat pattern. A list of signs and symptoms indicating one of the four TCM patterns and a list of preferred treatment modalities for each pattern were also generated. Our instrument shows considerable content validity. Further validity and reliability studies are under way.

  18. TCM Pattern Questionnaire for Lateral Elbow Pain: Development of an Instrument via a Delphi Process.

    PubMed

    Gadau, Marcus; Zhang, Shi-Ping; Yeung, Wing-Fai; Bian, Zhao-Xiang; Lu, Ai-Ping

    2016-01-01

    Individualized acupuncture treatment has been practiced for pain therapy. This study used acupuncture treatment for lateral elbow pain (LEP) as an example to study the diagnostic practice of individualized acupuncture treatment. A provisional version of LEP pattern questionnaire was developed based on a recent systematic review on TCM pattern diagnosis for LEP. A Delphi panel of 33 clinical experts from seven different countries was formed, and the Delphi survey was conducted in Chinese and English language for two rounds. Consensus was achieved from all 26 panelists who responded to the second round on 243 items of the instrument, which included a 72-question-long questionnaire. The mean level of expert consensus on the items of the final questionnaire was 85%. Consensus was found on four TCM patterns that could underlie LEP, namely, the wind-cold-dampness pattern, the qi stagnation and blood stasis pattern, the dual deficiency of qi and blood pattern, and the retained dampness-heat pattern. A list of signs and symptoms indicating one of the four TCM patterns and a list of preferred treatment modalities for each pattern were also generated. Our instrument shows considerable content validity. Further validity and reliability studies are under way. PMID:27525024

  19. Identification of Translational Dermatology Research Priorities in the UK; Results of an e-Delphi Exercise

    PubMed Central

    Healy, E.; Reynolds, N.J.

    2016-01-01

    Summary Background Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2,000 different skin diseases, thus there are considerable challenges in seeking to undertake research on each of these disorders. Objective This eDelphi exercise was conducted in order to generate a list of translational dermatology research questions which are regarded as a priority for further investigations. Results During the first phase of the eDelphi, 228 research questions were generated by an expert panel which included clinical academic dermatologists, clinical dermatologists, non-clinical scientists, dermatology trainees and representatives from patient support groups. Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders / genodermatoses, 37 questions on skin cancer and 8 miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma (SCC) and melanoma), there were a number of cross-cutting themes which identified a need to investigate mechanisms / pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusion It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the UK and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of subjects with skin disorders. PMID:26149834

  20. Electric and hybrid electric vehicles: A technology assessment based on a two-stage Delphi study

    SciTech Connect

    Vyas, A.D.; Ng, H.K.; Santini, D.J.; Anderson, J.L.

    1997-12-01

    To address the uncertainty regarding future costs and operating attributes of electric and hybrid electric vehicles, a two stage, worldwide Delphi study was conducted. Expert opinions on vehicle attributes, current state of the technology, possible advancements, costs, and market penetration potential were sought for the years 2000, 2010, and 2020. Opinions related to such critical components as batteries, electric drive systems, and hybrid vehicle engines, as well as their respective technical and economic viabilities, were also obtained. This report contains descriptions of the survey methodology, analytical approach, and results of the analysis of survey data, together with a summary of other factors that will influence the degree of market success of electric and hybrid electric vehicle technologies. Responses by industry participants, the largest fraction among all the participating groups, are compared with the overall responses. An evaluation of changes between the two Delphi stages is also summarized. An analysis of battery replacement costs for various types is summarized, and variable operating costs for electric and hybrid vehicles are compared with those of conventional vehicles. A market penetration analysis is summarized, in which projected market shares from the survey are compared with predictions of shares on the basis of two market share projection models that use the cost and physical attributes provided by the survey. Finally, projections of market shares beyond the year 2020 are developed by use of constrained logit models of market shares, statistically fitted to the survey data.

  1. Identifying Ethical Issues in Mental Health Research with Minors Adolescents: Results of a Delphi Study

    PubMed Central

    Hiriscau, Elisabeta Ioana; Stingelin-Giles, Nicola; Wasserman, Danuta; Reiter-Theil, Stella

    2016-01-01

    Research with minors, especially for preventive purposes, e.g., suicide prevention, investigating risk or self-destructive behaviors such as deviance, drug abuse, or suicidal behavior, is ethically sensitive. We present a Delphi study exploring the ethical implications of the needs formulated by researchers in an international pre-conference who would benefit from ethics support and guidance in conducting Mental Health Research with minors. The resulting List of Ethical Issues (LEI) was submitted to a 2-rounds Delphi process via the Internet, including 34 multidisciplinary experts. In the first round, the experts reviewed the LEI and completed a questionnaire. Results from this round were analyzed and grouped in nine categories comprising 40 items. In the second round, the experts had to agree/disagree with the needs expressed in the LEI leading to a final list of 25 ethical issues considered relevant for Mental Health Research with minors such as: confidentiality of the sensitive data, competence for consenting alone and risk of harm and stigma related to the methodology used in research. It was shown that studies like SEYLE (Saving and Empowering Young Lives in Europe) trigger among researchers wishes to obtain specific recommendations helping to comply with standards for good practice in conducting research with minors. PMID:27187425

  2. Estimating the impact of interventions on cause-specific maternal mortality: a Delphi approach

    PubMed Central

    2013-01-01

    Background Approximately 287,000 women die of causes related to pregnancy and childbirth every year. While effective interventions exist to prevent maternal death, high quality impact evaluations for these interventions are often lacking. Methods We conducted a Delphi process consisting of three rounds in which we asked maternal health experts to provide effectiveness estimates for 31 intervention-cause of death pairs relating to maternal mortality. Anonymous feedback in the form of medians and histograms for each question was given to experts following the first and second rounds. A diverse panel of 37 experts completed all three rounds, for a final response rate 80.4%. Results This Delphi process produced a total of 31 effectiveness estimates for key maternal interventions on cause-specific maternal mortality. Overall, many interventions had high estimated effectiveness, with the majority of interventions having effectiveness estimates above 70%. Where possible, the estimates of effectiveness of interventions were compared to previous efforts and in general there was strong agreement between the estimates in this exercise as compared to those of earlier efforts. Conclusions There are many maternal health interventions with high estimated effectiveness that, with expansion of effective delivery channels, have the potential to have a large impact on reducing maternal mortality worldwide.

  3. First aid guidelines for psychosis in Asian countries: A Delphi consensus study

    PubMed Central

    Jorm, Anthony F; Minas, Harry; Langlands, Robyn L; Kelly, Claire M

    2008-01-01

    Background Guidelines for how a member of the public should give first aid to a person who is becoming psychotic have been developed for English-speaking countries. However, these guidelines may not be appropriate for use in other cultures. A study was therefore carried out to examine whether it was possible to achieve consensus on guidelines that could apply in a range of Asian countries. Methods A Delphi consensus study was carried out with a panel of 28 Asian mental health clinicians drawn from Cambodia, China, Hong Kong, Indonesia, Japan, Malaysia, Mongolia, South Korea, Sri Lanka, Taiwan, Thailand and Vietnam. The panel was given a 211 item questionnaire about possible first aid actions and asked to rate whether they thought these should be included in guidelines. Panel members were invited to propose additional items. Results After three Delphi rounds, there were 128 items that were rated as "essential" or "important" by 80% or more of the panel members. These items covered: recognition of psychosis, encouraging and assisting the person to seek help, how to interact with the person, responding to acute psychosis, responding to aggression, and what to do if the person refuses to get professional help. Conclusion Despite the diversity of the countries involved, there was consensus on a core set of first aid items that were considered as suitable for assisting a psychotic person. Future work is needed to develop guidelines for specific countries. PMID:18291042

  4. Identifying management competencies for health care executives: review of a series of Delphi studies.

    PubMed

    Hudak, R P; Brooke, P P; Finstuen, K

    2000-01-01

    This analysis reviews a selected body of research that identifies the essential areas of management expertise required of future health care executives. To ensure consistency, six studies are analyzed, utilizing the Delphi technique, to query a broad spectrum of experts in different fields and sites of health care management. The analysis identifies a number of management competencies, i.e., managerial capabilities, which current and aspiring health care executives, in various settings and with differing educational backgrounds, should possess to enhance the probability of their success in current and future positions of responsibility. In addition, this review identifies the skills (technical expertise), knowledge (facts and principles) and abilities (physical, mental or legal power) required to support achievement of these competencies. Leadership and resource management, including cost and finance dimensions, are the highest-rated requisite management competencies. The dominant skills, knowledge and abilities (SKAs) are related to interpersonal skills. The lowest-rated SKAs are related to job-specific, technical skills. Recommendations include the review of this research by formal and continuing education programs to determine the content of their courses and areas for future research. Similarly, current health care executives should assess this research to assist in identifying competency gaps. Lastly, this analysis recommends that the Delphi technique, as a valid and replicable methodology, be applied toward the study of non-executive health care managers, e.g., students, clinicians, mid-level managers and integrated systems administrators, to determine their requisite management competencies and SKAs.

  5. TCM Pattern Questionnaire for Lateral Elbow Pain: Development of an Instrument via a Delphi Process

    PubMed Central

    Bian, Zhao-Xiang

    2016-01-01

    Individualized acupuncture treatment has been practiced for pain therapy. This study used acupuncture treatment for lateral elbow pain (LEP) as an example to study the diagnostic practice of individualized acupuncture treatment. A provisional version of LEP pattern questionnaire was developed based on a recent systematic review on TCM pattern diagnosis for LEP. A Delphi panel of 33 clinical experts from seven different countries was formed, and the Delphi survey was conducted in Chinese and English language for two rounds. Consensus was achieved from all 26 panelists who responded to the second round on 243 items of the instrument, which included a 72-question-long questionnaire. The mean level of expert consensus on the items of the final questionnaire was 85%. Consensus was found on four TCM patterns that could underlie LEP, namely, the wind-cold-dampness pattern, the qi stagnation and blood stasis pattern, the dual deficiency of qi and blood pattern, and the retained dampness-heat pattern. A list of signs and symptoms indicating one of the four TCM patterns and a list of preferred treatment modalities for each pattern were also generated. Our instrument shows considerable content validity. Further validity and reliability studies are under way. PMID:27525024

  6. Alternative method of highway traffic safety analysis for developing countries using delphi technique and Bayesian network.

    PubMed

    Mbakwe, Anthony C; Saka, Anthony A; Choi, Keechoo; Lee, Young-Jae

    2016-08-01

    Highway traffic accidents all over the world result in more than 1.3 million fatalities annually. An alarming number of these fatalities occurs in developing countries. There are many risk factors that are associated with frequent accidents, heavy loss of lives, and property damage in developing countries. Unfortunately, poor record keeping practices are very difficult obstacle to overcome in striving to obtain a near accurate casualty and safety data. In light of the fact that there are numerous accident causes, any attempts to curb the escalating death and injury rates in developing countries must include the identification of the primary accident causes. This paper, therefore, seeks to show that the Delphi Technique is a suitable alternative method that can be exploited in generating highway traffic accident data through which the major accident causes can be identified. In order to authenticate the technique used, Korea, a country that underwent similar problems when it was in its early stages of development in addition to the availability of excellent highway safety records in its database, is chosen and utilized for this purpose. Validation of the methodology confirms the technique is suitable for application in developing countries. Furthermore, the Delphi Technique, in combination with the Bayesian Network Model, is utilized in modeling highway traffic accidents and forecasting accident rates in the countries of research. PMID:27183516

  7. Criteria for Site Selection of Temporary Shelters after Earthquakes: a Delphi Panel

    PubMed Central

    Soltani, Ahmad; Ardalan, Ali; Darvishi Boloorani, Ali; Haghdoost, AliAkbar; Hosseinzadeh-Attar, Mohammad Javad

    2015-01-01

    Introduction: After a devastating earthquake, the site selection for the sheltering of earthquake victims is an important task. In order to generate a list of appropriate criteria for deciding on temporary sheltering site selection, we systematically combined the experience of experts and the findings of published documents in this study. Methods: Having explored published papers, we generated a list of criteria for the selection of the best location for temporary sheltering. In the next step, all criteria were presented to a group of experts in Iran and after a scientific discussion, the list was updated. In the last step, the final list of criteria was developed using the Delphi method in three rounds. Results: Based on our previous systematic review, 27 criteria were presented for sheltering site selection. Expert interviews added 12 more items to them. The Delphi process approved 21 criteria of all proposed ones. These items then grouped into four categories: land suitability, socio-cultural considerations, service availability and disaster risk reduction. Discussion: After an earthquake, our list of criteria may help the disaster team to select the best locations for temporary sheltering with minimum confusion. The consent of the earthquake victims and cost reduction of the operation would be the minimum benefits of using the appropriate criteria. These criteria also could be used by researchers to make objective and reproducible assessments of temporary sheltering site selection. Key words: Criteria, Earthquake, Model, Site selection, Temporary shelter, PMID:26693079

  8. STEM integration in middle school career and technical education programs: A Delphi design study

    NASA Astrophysics Data System (ADS)

    Wu-Rorrer, Billy Ray

    The purpose of this qualitative method study with a Delphi research design sought to determine how STEM programs can be effectively integrated into middle school career and technical education programs by local, state, and national educators, administrators, directors, specialists, and curriculum writers. The significance of the study is to provide leaders in CTE with a greater awareness, insight, and strategies about how CTE programs can more effectively integrate academics into career and technical education programs through STEM-related programming. The findings will increase the limited amount of available literature providing best practice strategies for the integration of STEM curriculum into middle school CTE programs. One basic question has guided this research: How can STEM programs be effectively integrated into middle school career and technical education programs? A total of twelve strategies were identified. The strategies of real-world applications and administrative buy-in were the two predominant strategies consistently addressed throughout the review of literature and all three sub-questions in the research study. The Delphi design study consisted of pilot round and three rounds of data collection on barriers, strategies, and professional development for STEM integration in middle school career and technical education programs. Four panelists participated in the pilot round, and 16 panel members not involved in the pilot round participated in the three rounds of questioning and consensus building. In the future, more comprehensive studies can build upon this foundational investigation of middle school CTE programs.

  9. Identifying management competencies for health care executives: review of a series of Delphi studies.

    PubMed

    Hudak, R P; Brooke, P P; Finstuen, K

    2000-01-01

    This analysis reviews a selected body of research that identifies the essential areas of management expertise required of future health care executives. To ensure consistency, six studies are analyzed, utilizing the Delphi technique, to query a broad spectrum of experts in different fields and sites of health care management. The analysis identifies a number of management competencies, i.e., managerial capabilities, which current and aspiring health care executives, in various settings and with differing educational backgrounds, should possess to enhance the probability of their success in current and future positions of responsibility. In addition, this review identifies the skills (technical expertise), knowledge (facts and principles) and abilities (physical, mental or legal power) required to support achievement of these competencies. Leadership and resource management, including cost and finance dimensions, are the highest-rated requisite management competencies. The dominant skills, knowledge and abilities (SKAs) are related to interpersonal skills. The lowest-rated SKAs are related to job-specific, technical skills. Recommendations include the review of this research by formal and continuing education programs to determine the content of their courses and areas for future research. Similarly, current health care executives should assess this research to assist in identifying competency gaps. Lastly, this analysis recommends that the Delphi technique, as a valid and replicable methodology, be applied toward the study of non-executive health care managers, e.g., students, clinicians, mid-level managers and integrated systems administrators, to determine their requisite management competencies and SKAs. PMID:11183260

  10. Identifying Ethical Issues in Mental Health Research with Minors Adolescents: Results of a Delphi Study.

    PubMed

    Hiriscau, Elisabeta Ioana; Stingelin-Giles, Nicola; Wasserman, Danuta; Reiter-Theil, Stella

    2016-05-11

    Research with minors, especially for preventive purposes, e.g., suicide prevention, investigating risk or self-destructive behaviors such as deviance, drug abuse, or suicidal behavior, is ethically sensitive. We present a Delphi study exploring the ethical implications of the needs formulated by researchers in an international pre-conference who would benefit from ethics support and guidance in conducting Mental Health Research with minors. The resulting List of Ethical Issues (LEI) was submitted to a 2-rounds Delphi process via the Internet, including 34 multidisciplinary experts. In the first round, the experts reviewed the LEI and completed a questionnaire. Results from this round were analyzed and grouped in nine categories comprising 40 items. In the second round, the experts had to agree/disagree with the needs expressed in the LEI leading to a final list of 25 ethical issues considered relevant for Mental Health Research with minors such as: confidentiality of the sensitive data, competence for consenting alone and risk of harm and stigma related to the methodology used in research. It was shown that studies like SEYLE (Saving and Empowering Young Lives in Europe) trigger among researchers wishes to obtain specific recommendations helping to comply with standards for good practice in conducting research with minors.

  11. Automating the design of image processing pipelines for novel color filter arrays: local, linear, learned (L3) method

    NASA Astrophysics Data System (ADS)

    Tian, Qiyuan; Lansel, Steven; Farrell, Joyce E.; Wandell, Brian A.

    2014-03-01

    The high density of pixels in modern color sensors provides an opportunity to experiment with new color filter array (CFA) designs. A significant bottleneck in evaluating new designs is the need to create demosaicking, denoising and color transform algorithms tuned for the CFA. To address this issue, we developed a method(local, linear, learned or L3) for automatically creating an image processing pipeline. In this paper we describe the L3 algorithm and illustrate how we created a pipeline for a CFA organized as a 2×2 RGB/Wblock containing a clear (W) pixel. Under low light conditions, the L3 pipeline developed for the RGB/W CFA produces images that are superior to those from a matched Bayer RGB sensor. We also use L3 to learn pipelines for other RGB/W CFAs with different spatial layouts. The L3 algorithm shortens the development time for producing a high quality image pipeline for novel CFA designs.

  12. An Analysis of Factors that Inhibit Business Use of User-Centered Design Principles: A Delphi Study

    ERIC Educational Resources Information Center

    Hilton, Tod M.

    2010-01-01

    The use of user-centered design (UCD) principles has a positive impact on the use of web-based interactive systems in customer-centric organizations. User-centered design methodologies are not widely adopted in organizations due to intraorganizational factors. A qualitative study using a modified Delphi technique was used to identify the factors…

  13. Identifying Areas of Tension in the Field of Technology-Enhanced Learning: Results of an International Delphi Study

    ERIC Educational Resources Information Center

    Plesch, Christine; Kaendler, Celia; Rummel, Nikol; Wiedmann, Michael; Spada, Hans

    2013-01-01

    Despite steady progress in research in technology-enhanced learning (TEL), the translation of research findings and technology into educational practices falls short of expectations. We present five Areas of Tension which were identified and evaluated in an international Delphi study on TEL. These tensions might impede a more comprehensive…

  14. Identification of Response Options to Artisanal and Small-Scale Gold Mining (ASGM) in Ghana via the Delphi Process

    PubMed Central

    Basu, Avik; Phipps, Sean; Long, Rachel; Essegbey, George; Basu, Niladri

    2015-01-01

    The Delphi technique is a means of facilitating discussion among experts in order to develop consensus, and can be used for policy formulation. This article describes a modified Delphi approach in which 27 multi-disciplinary academics and 22 stakeholders from Ghana and North America were polled about ways to address negative effects of small-scale gold mining (ASGM) in Ghana. In early 2014, the academics, working in disciplinary groups, synthesized 17 response options based on data aggregated during an Integrated Assessment of ASGM in Ghana. The researchers participated in two rounds of Delphi polling in March and April 2014, during which 17 options were condensed into 12. Response options were rated via a 4-point Likert scale in terms of benefit (economic, environmental, and benefit to people) and feasibility (economic, social/cultural, political, and implementation). The six highest-scoring options populated a third Delphi poll, which 22 stakeholders from diverse sectors completed in April 2015. The academics and stakeholders also prioritized the response options using ranking exercises. The technique successfully gauged expert opinion on ASGM, and helped identify potential responses, policies and solutions for the sector. This is timely given that improvement to the ASGM sector is an important component within the UN Minamata Convention. PMID:26378557

  15. Essential Concepts of Nanoscale Science and Technology for High School Students Based on a Delphi Study by the Expert Community

    ERIC Educational Resources Information Center

    Sakhnini, Sohair; Blonder, Ron

    2015-01-01

    Nanoscale science and technology (NST) is an important new field in modern science. In the current study, we seek to answer the question: "What are the essential concepts of NST that should be taught in high school"? A 3-round Delphi study methodology was applied based on 2 communities of experts in nanotechnology research and science…

  16. Convergence on the Guidelines for Designing a Web-Based Art-Teacher Education Curriculum: A Delphi Study.

    ERIC Educational Resources Information Center

    Yang, Yu Nu

    The rise of the World Wide Web as a new information processing technology has attracted the attention of educators worldwide. The purpose of this study was to seek a consensus among art education experts regarding how the Web should be integrated into the art teacher education curricula. The Delphi Method was applied for seeking a consensus. A…

  17. "Normal" and "Inappropriate" Childhood Sexual Behaviours: Findings from a Delphi Study of Professionals in the United Kingdom

    ERIC Educational Resources Information Center

    Vosmer, Susanne; Hackett, Simon; Callanan, Margie

    2009-01-01

    This paper presents the results of a three-stage Delphi study examining the current level of consensus among 24 professionals in the United Kingdom regarding definitions of and distinctions between normal, inappropriate and sexually abusive behaviours in children under 10 years, as well as factors influencing their views. Although firm conclusions…

  18. Understanding and Defining Cognitive Style and Learning Style: A Delphi Study in the Context of Educational Psychology

    ERIC Educational Resources Information Center

    Armstrong, Steven J.; Peterson, Elizabeth R.; Rayner, Stephen G.

    2012-01-01

    This report outlines the findings from a Delphi study designed to establish consensus on the definitions of cognitive style and learning style amongst an international style researcher community. The study yields long-needed definitions for each construct that reflect high levels of agreement. In a field that has been criticised for a bewildering…

  19. The Finnish Delphi Study: Forecasting the Extent of Information Technology Use in Libraries in 1996 and 2010.

    ERIC Educational Resources Information Center

    Koskiala, Sinnikka; Huhtanen, Anni

    1989-01-01

    Describes a Delphi study in which Finnish experts predicted the extent of information technology use in libraries and information centers. Predictions are summarized in the areas of workstations; fax and electronic mail; videotex; print, electronic, and optical publishing; indexing and storage of sounds and images; speech recognition and scanning…

  20. A Study to Identify the Training Needs of Life Insurance Sales Representatives in Taiwan Using the Delphi Approach

    ERIC Educational Resources Information Center

    Fan, Chiang Ku; Cheng, Chen-Liang

    2006-01-01

    This article reports a study conducted to identify the needs for continuing professional development for life insurance sales representatives and to examine the competencies needed by those sales representatives. A modified Delphi technique was used. Most life insurance companies in the USA implement an education and training plan advocated by the…

  1. Practices and Challenges in Educational Program Evaluation in the Asia-Pacific Region: Results of a Delphi Study

    ERIC Educational Resources Information Center

    Lee, Yi-Fang; Altschuld, James W.; Hung, Hsin-Ling

    2008-01-01

    While educational program evaluation has become more important in recent years because of increasing governmental demands for accountability, little is known about the development of and issues in regard to this topic in the Asia-Pacific region. The findings from a Delphi study conducted in a number of relevant countries are provided in this…

  2. Identification of Response Options to Artisanal and Small-Scale Gold Mining (ASGM) in Ghana via the Delphi Process.

    PubMed

    Basu, Avik; Phipps, Sean; Long, Rachel; Essegbey, George; Basu, Niladri

    2015-09-10

    The Delphi technique is a means of facilitating discussion among experts in order to develop consensus, and can be used for policy formulation. This article describes a modified Delphi approach in which 27 multi-disciplinary academics and 22 stakeholders from Ghana and North America were polled about ways to address negative effects of small-scale gold mining (ASGM) in Ghana. In early 2014, the academics, working in disciplinary groups, synthesized 17 response options based on data aggregated during an Integrated Assessment of ASGM in Ghana. The researchers participated in two rounds of Delphi polling in March and April 2014, during which 17 options were condensed into 12. Response options were rated via a 4-point Likert scale in terms of benefit (economic, environmental, and benefit to people) and feasibility (economic, social/cultural, political, and implementation). The six highest-scoring options populated a third Delphi poll, which 22 stakeholders from diverse sectors completed in April 2015. The academics and stakeholders also prioritized the response options using ranking exercises. The technique successfully gauged expert opinion on ASGM, and helped identify potential responses, policies and solutions for the sector. This is timely given that improvement to the ASGM sector is an important component within the UN Minamata Convention.

  3. Critical Factors Affecting the Assessment of Student Learning Outcomes: A Delphi Study of the Opinions of Community College Personnel

    ERIC Educational Resources Information Center

    Somerville, Jerry

    2008-01-01

    The purpose of this qualitative study was to identify critically important factors that affect the meaningful assessment of student learning outcomes and study why these factors were critically important. A three-round Delphi process was used to solicit the opinions of individuals who were actively involved in student learning outcomes assessment…

  4. Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate

    SciTech Connect

    Misaghi, S.; Galardy, P.J.; Meester, W.J.; Ovaa, H.; Ploegh, H.L.; Gaudet, R.

    2009-03-24

    Ubiquitin C-terminal hydrolases (UCHs) comprise a family of small ubiquitin-specific proteases of uncertain function. Although no cellular substrates have been identified for UCHs, their highly tissue-specific expression patterns and the association of UCH-L1 mutations with human disease strongly suggest a critical role. The structure of the yeast UCH Yuh1-ubiquitin aldehyde complex identified an active site crossover loop predicted to limit the size of suitable substrates. We report the 1.45 {angstrom} resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases. This structure confirms the predicted mechanism of the inhibitor and allows the direct comparison of a UCH family enzyme in the free and ligand-bound state. We also show the efficient hydrolysis by human UCH-L3 of a 13-residue peptide in isopeptide linkage with ubiquitin, consistent with considerable flexibility in UCH substrate size. We propose a model for the catalytic cycle of UCH family members which accounts for the hydrolysis of larger ubiquitin conjugates.

  5. The Formation and Evolution of Energetic Transient Proton Belts Near L = 3

    NASA Astrophysics Data System (ADS)

    Claudepierre, S. G.; Roeder, J. L.; Blake, J. B.; Fennell, J. F.

    2011-12-01

    Solar energetic particle (SEP) events are one of many space weather events that can be hazardous to spacecraft operating in the near-Earth plasma environment. During an SEP, energetic protons (~20 MeV) can penetrate deep into the magnetosphere, at times to very low L shells (L~3). Under some circumstances, these injected protons can become stably trapped and persist for many days, thus forming a new proton belt in a region that is typically devoid of energetic protons. This can serve as a potential unforeseen hazard for spacecraft operating in this region of geospace. We use recent observations from the Polar-CEPPAD investigation and HEO spacecraft to examine the formation and evolution of energetic transient proton belts near L = 3. We consider several events where transient proton belts are associated with storm-sudden commencements driven by interplanetary shocks. Angular distributions obtained from the CEPPAD-HIST sensor on-board the Polar spacecraft reveal features that are difficult to reconcile with standard trapped particle theory. For example, the pitch-angle distributions are observed to vary substantially on timescales faster than what would be expected for a diffusive mechanism. We compare the HIST observations with simultaneous measurements in HEO and explore possible explanations for the rapid changes observed in the angular distributions.

  6. Exome sequencing identified a missense mutation of EPS8L3 in Marie Unna hereditary hypotrichosis

    PubMed Central

    Zhang, Xin; Guo, Bi-Rong; Cai, Li-Qiong; Jiang, Tao; Sun, Liang-Dan; Cui, Yong; Hu, Jing-Chu; Zhu, Jun; Chen, Gang; Tang, Xian-Fa; Sun, Guang-Qing; Tang, Hua-Yang; Liu, Yuan; Li, Min; Li, Qi-Bin; Cheng, Hui; Gao, Min; Li, Ping; Yang, Xu; Zuo, Xian-Bo; Zheng, Xiao-Dong; Wang, Pei-Guang; Wang, Jian; Wang, Jun; Liu, Jian-Jun; Yang, Sen; Li, Ying-Rui; Zhang, Xue-Jun

    2012-01-01

    Background Marie Unna hereditary hypotrichosis (MUHH) is an autosomal dominant disorder characterised by coarse, wiry, twisted hair developed in early childhood and subsequent progressive hair loss. MUHH is a genetically heterogeneous disorder. No gene in 1p21.1–1q21.3 region responsible for MUHH has been identified. Methods Exome sequencing was performed on two affected subjects, who had normal vertex hair and modest alopecia, and one unaffected individual from a four-generation MUHH family of which our previous linkage study mapped the MUHH locus on chromosome 1p21.1–1q21.3. Results We identified a missense mutation in EPS8L3 (NM_024526.3: exon2: c.22G->A:p.Ala8Thr) within 1p21.1–1q21.3. Sanger sequencing confirmed the cosegregation of this mutation with the disease phenotype in the family by demonstrating the presence of the heterozygous mutation in all the eight affected and absence in all the seven unaffected individuals. This mutation was found to be absent in 676 unrelated healthy controls and 781 patients of other disease from another unpublished project of our group. Conclusions Taken together, our results suggest that EPS8L3 is a causative gene for MUHH, which was helpful for advancing us on understanding of the pathogenesis of MUHH. Our study also has further demonstrated the effectiveness of combining exome sequencing with linkage information for identifying Mendelian disease genes. PMID:23099647

  7. Study plan to identify long term national telecommunications need and priorities applying Delphi techniques (handbook). [technological forecasting - United States of America

    NASA Technical Reports Server (NTRS)

    1974-01-01

    A handbook that explains the basic Delphi methodology and discusses modified Delphi techniques is presented. The selection of communications experts to participate in a study, the construction of questionnaires on potential communications developments, and requisite technology is treated. No two modified Delphi studies were the same, which reflects the flexibility and adaptability of the technique. Each study must be specifically tailored to a particular case, and consists of seeking a consensus of opinion among experts about a particular subject and attendant conditions that may prevail in the future.

  8. PIPc study: development of indicators of potentially inappropriate prescribing in children (PIPc) in primary care using a modified Delphi technique

    PubMed Central

    Barry, Emma; O'Brien, Kirsty; Cooper, Janine; Redmond, Patrick; Hughes, Carmel M; Bennett, Kathleen; Fahey, Tom; Smith, Susan M

    2016-01-01

    Objective There is limited evidence regarding the quality of prescribing for children in primary care. Several prescribing criteria (indicators) have been developed to assess the appropriateness of prescribing in older and middle-aged adults but few are relevant to children. The objective of this study was to develop a set of prescribing indicators that can be applied to prescribing or dispensing data sets to determine the prevalence of potentially inappropriate prescribing in children (PIPc) in primary care settings. Design Two-round modified Delphi consensus method. Setting Irish and UK general practice. Participants A project steering group consisting of academic and clinical general practitioners (GPs) and pharmacists was formed to develop a list of indicators from literature review and clinical expertise. 15 experts consisting of GPs, pharmacists and paediatricians from the Republic of Ireland and the UK formed the Delphi panel. Results 47 indicators were reviewed by the project steering group and 16 were presented to the Delphi panel. In the first round of this exercise, consensus was achieved on nine of these indicators. Of the remaining seven indicators, two were removed following review of expert panel comments and discussion of the project steering group. The second round of the Delphi process focused on the remaining five indicators, which were amended based on first round feedback. Three indicators were accepted following the second round of the Delphi process and the remaining two indicators were removed. The final list consisted of 12 indicators categorised by respiratory system (n=6), gastrointestinal system (n=2), neurological system (n=2) and dermatological system (n=2). Conclusions The PIPc indicators are a set of prescribing criteria developed for use in children in primary care in the absence of clinical information. The utility of these criteria will be tested in further studies using prescribing databases. PMID:27601499

  9. Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP

    PubMed Central

    Russo, Annapina; Catillo, Morena; Esposito, Davide; Briata, Paola; Pietropaolo, Concetta; Russo, Giulia

    2011-01-01

    Alternative pre-mRNA splicing (AS) is a major mechanism that allows proteomic variability in eukaryotic cells. However, many AS events result in mRNAs containing a premature termination codon, which are degraded by nonsense-mediated mRNA decay (NMD) pathway. We have previously demonstrated that human rpL3 autoregulates its expression through the association of AS with NMD. In fact, overexpression of rpL3 promotes downregulation of canonical splicing and upregulation of alternative splicing that produces an NMD-targeted mRNA isoform. The result of these events is a decreased production of rpL3. We have also identified heterogeneous nuclear ribonucleoprotein (hnRNP) H1 as a splicing factor involved in the regulation of rpL3 alternative splicing and identified its regulatory cis-elements within intron 3 transcript. Here, we report that NPM and KHSRP are two newly identified proteins involved in the regulation of rpL3 gene expression via AS-NMD. We demonstrate that hnRNP H1, KHSRP and NPM can be found associated, and present also in ribonucleoproteins (RNPs) including rpL3 and intron 3 RNA in vivo, and describe protein–protein and RNA–protein interactions. Moreover, our data provide an insight on the crucial role of hnRNP H1 in the regulation of the alternative splicing of the rpL3 gene. PMID:21705779

  10. Linking NHS data for pediatric pharmacovigilance: Results of a Delphi survey

    PubMed Central

    Hopf, Y.M.; Francis, J.; Helms, P.J.; Haughney, J.; Bond, C.

    2016-01-01

    Background Adverse drug events are a major cause of patient safety incidents. Current systems of pharmacovigilance under-report adverse drug reactions (ADRs), especially in children, leading to delays in their identification. This is of particular concern, as children especially have an increased vulnerability to ADRs. Objectives The objective was to seek consensus among healthcare professionals (HCPs) about barriers and facilitators to the linkage of routinely collected health data for pediatric pharmacovigilance in Scotland. Methods A Delphi survey was conducted with a random sample of HCPs including nurses, pharmacists and doctors, working in primary or secondary care, in Scotland. Participants were identified from sampling frames of the target professionals such as an NHS workforce list for general practitioners and recruited by postal invitation. A total of 819 HCPs were invited to take part. Those agreeing to participate were given the option of completing the questionnaires online or as hard copy. Reminders were sent twice at a fortnightly interval. Questions content included description of professional role as well as testing for the willingness to support the proposed project and was informed by the Theoretical Domains Framework of Behavior Change (TDF) and earlier qualitative work. Three Delphi rounds were administered, including a first round for item generation. Results 121 of those invited agreed to take part (15%). The first round of the Delphi study included 21 open questions and generated over a 1000 individual statements from 61 participants that returned the questionnaires (50.4%). These were rationalized to 149 items for the second round in which participants rated their views on the importance (or not) of each item on a 9-point Likert scale (strongly disagree – strongly agree). After the third round, there was consensus on items that focused on professional standards, and practical requirements, overall there was support for data linkage and a

  11. A Delphi Process to Optimize Quality and Performance of Drug Evaluation in Neonates

    PubMed Central

    Legrand, Frederic; Boulkedid, Rym; Elie, Valery; Leroux, Stephanie; Valls, Elizabeth; Van den Anker, Johannes N.; Jacqz-Aigrain, Evelyne

    2014-01-01

    Background Neonatal trials remain difficult to conduct for several reasons: in particular the need for study sites to have an existing infrastructure in place, with trained investigators and validated quality procedures to ensure good clinical, laboratory practices and a respect for high ethical standards. The objective of this work was to identify the major criteria considered necessary for selecting neonatal intensive care units that are able to perform drug evaluations competently. Methodology and Main Findings This Delphi process was conducted with an international multidisciplinary panel of 25 experts from 13 countries, selected to be part of two committees (a scientific committee and an expert committee), in order to validate criteria required to perform drug evaluation in neonates. Eighty six items were initially selected and classified under 7 headings: “NICUs description - Level of care” (21), “Ability to perform drug trials: NICU organization and processes (15), “Research Experience” (12), “Scientific competencies and area of expertise” (8), “Quality Management” (16), “Training and educational capacity” (8) and “Public involvement” (6). Sixty-one items were retained and headings were rearranged after the first round, 34 were selected after the second round. A third round was required to validate 13 additional items. The final set includes 47 items divided under 5 headings. Conclusion A set of 47 relevant criteria will help to NICUs that want to implement, conduct or participate in drug trials within a neonatal network identify important issues to be aware of. Summary Points 1) Neonatal trials remain difficult to conduct for several reasons: in particular the need for study sites to have an existing infrastructure in place, with trained investigators and validated quality procedures to ensure good clinical, laboratory practices and a respect for high ethical standards. 2) The present Delphi study was conducted with an

  12. Antihelmintic effects of nutmeg (Myristica fragans) on Anisakis simplex L3 larvae obtained from Micromesistius potassou.

    PubMed

    López, Víctor; Gerique, Javier; Langa, Elisa; Berzosa, César; Valero, Marta Sofía; Gómez-Rincón, Carlota

    2015-06-01

    Anisakis simplex is a foodborne pathogen that can produce human infections and allergic reactions due to the high consumption of raw fish. The seeds of Myristica fragans (Myristicaceae), popularly known as nutmeg, are worldwide used as a culinary spice due to its flavour and properties in food preservation. A nutmeg extract was prepared, analyzed, screened for cytotoxicity and tested against Anisakis simplex L3 larvae. In order to detect the biologically active constituents of the extract, myristicin was tested on the larvae. An acetylcholinesterase inhibition bioassay was also carried out to investigate the antihelmintic mechanism of action. Our results demonstrate that nutmeg exerts antihelmintic effects on Anisakis simplex, being myristicin one of the active compounds. The extract induced a high rate of dead anisakis at concentrations between 0.5 and 0.7 mg/ml without being considered cytotoxic; however, an inhibition of acetylcholinesterase was discarded as the molecular mechanism involved in the activity.

  13. Activity of tea tree (Melaleuca alternifolia) essential oil against L3 larvae of Anisakis simplex.

    PubMed

    Gómez-Rincón, Carlota; Langa, Elisa; Murillo, Paula; Valero, Marta Sofía; Berzosa, César; López, Víctor

    2014-01-01

    Nematicidal activity of Melaleuca alternifolia essential oil, commonly known as tea tree oil (TTO), was assayed in vitro against L3 larvae of Anisakis simplex. The results showed a mortality of 100% for concentrations between 7 and 10 μL/mL after 48 h of incubation, obtaining an LD50 value of 4.53 μL/mL after 24 hours and 4.27 μL/mL after 48 hours. Concentration-dependent inhibition of acetylcholinesterase was observed for tea tree essential oil showing inhibition values of 100% at 100 μL/mL. This fact suggests that TTO may act as an AChE inhibitor. Terpinen-4-ol was discarded as main larvicide compound as it did not show larvicidal or anticholinesterase activity. The data obtained suggest that the essential oil of Melaleuca alternifolia may have a great therapeutic potential for the treatment of human anisakiasis.

  14. Knockout from {sup 46}Ar:l=3 neutron removal and deviations from eikonal theory

    SciTech Connect

    Gade, A.; Bazin, D.; Enders, J.; Hu, Z.; Mueller, W.F.; Bertulani, C.A.; Brown, B.A.; Campbell, C.M.; Church, J.A.; Dinca, D.C.; Glasmacher, T.; Hansen, P.G.; Olliver, H.; Perry, B.C.; Sherrill, B.M.; Terry, J.R.; Yurkewicz, K.L.; Kemper, K.W.; Roeder, B.T.; Riley, L.A.

    2005-05-01

    The {sup 9}Be({sup 46}Ar,{sup 45}Ar+{gamma})X one-neutron removal reaction has been studied in inverse kinematics at 70 MeV/nucleon. Coincidences with {gamma} rays served to disentangle knockout events leading to the {sup 45}Ar ground state. The measured partial cross section corresponds to a spectroscopic factor of 4.9(7). The residue momentum distribution is compared with new calculations based on eikonal theory and represents the first case of an l=3 neutron removal, as is expected for populating a 0f{sub 7/2} hole in the N=28 projectile. However, the measured {sup 45}Ar momentum distribution has a marked low-momentum tail suggestive of dissipative effects whereas the eikonal model predictions are symmetric. The angular distribution of the residues confirms that there is a deviation from the model.

  15. Radiative corrections to the Dalitz plot of K{sub l3}{sup {+-}} decays

    SciTech Connect

    Juarez-Leon, C.; Martinez, A.; Neri, M.; Torres, J. J.; Flores-Mendieta, Ruben

    2011-03-01

    We calculate the model-independent radiative corrections to the Dalitz plot of K{sub l3}{sup {+-}} decays to the order of ({alpha}/{pi})(q/M{sub 1}), where q is the momentum transfer and M{sub 1} is the mass of the kaon. The final results are presented, first, with the triple integration over the variables of the bremsstrahlung photon ready to be performed numerically and, second, in an analytical form. These two forms are useful to cross-check on one another and with other calculations. This paper is organized to make it accessible and reliable in the analysis of the Dalitz plot of precision experiments and is not compromised to fixing the form factors at predetermined values. It is assumed that the real photons are kinematically discriminated. Otherwise, our results have a general model-independent applicability.

  16. Synthesis and characteristics of an aspartame analogue, L-asparaginyl L-3-phenyllactic acid methyl ester.

    PubMed

    Tao, Hu; Cui, Da-Fu; Zhang, You-Shang

    2004-06-01

    An aspartame analogue, L-asparaginyl L-3-phenyllactic acid methyl ester was synthesized with aspartic acid replaced by asparagine and peptide bond replaced by ester bond. The aspartic acid of aspartame could be replaced by asparagine as reported in the literature. In this analogue, the hydrogen of amide group could still form a hydrogen bond with the oxygen of ester bond and the ester bond was isosteric with peptide bond. However, the product was not sweet, showing that the peptide bond could not be replaced by ester bond. The peptide C-N bond behaves as a double bond that is not free to rotate and the C, O, N and H atoms are in the same plane. The replacement of peptide bond by ester bond destroyed the unique conformation of peptide bond, resulting in the loss of sweet taste.

  17. Antihelmintic effects of nutmeg (Myristica fragans) on Anisakis simplex L3 larvae obtained from Micromesistius potassou.

    PubMed

    López, Víctor; Gerique, Javier; Langa, Elisa; Berzosa, César; Valero, Marta Sofía; Gómez-Rincón, Carlota

    2015-06-01

    Anisakis simplex is a foodborne pathogen that can produce human infections and allergic reactions due to the high consumption of raw fish. The seeds of Myristica fragans (Myristicaceae), popularly known as nutmeg, are worldwide used as a culinary spice due to its flavour and properties in food preservation. A nutmeg extract was prepared, analyzed, screened for cytotoxicity and tested against Anisakis simplex L3 larvae. In order to detect the biologically active constituents of the extract, myristicin was tested on the larvae. An acetylcholinesterase inhibition bioassay was also carried out to investigate the antihelmintic mechanism of action. Our results demonstrate that nutmeg exerts antihelmintic effects on Anisakis simplex, being myristicin one of the active compounds. The extract induced a high rate of dead anisakis at concentrations between 0.5 and 0.7 mg/ml without being considered cytotoxic; however, an inhibition of acetylcholinesterase was discarded as the molecular mechanism involved in the activity. PMID:25890576

  18. Activity of tea tree (Melaleuca alternifolia) essential oil against L3 larvae of Anisakis simplex.

    PubMed

    Gómez-Rincón, Carlota; Langa, Elisa; Murillo, Paula; Valero, Marta Sofía; Berzosa, César; López, Víctor

    2014-01-01

    Nematicidal activity of Melaleuca alternifolia essential oil, commonly known as tea tree oil (TTO), was assayed in vitro against L3 larvae of Anisakis simplex. The results showed a mortality of 100% for concentrations between 7 and 10 μL/mL after 48 h of incubation, obtaining an LD50 value of 4.53 μL/mL after 24 hours and 4.27 μL/mL after 48 hours. Concentration-dependent inhibition of acetylcholinesterase was observed for tea tree essential oil showing inhibition values of 100% at 100 μL/mL. This fact suggests that TTO may act as an AChE inhibitor. Terpinen-4-ol was discarded as main larvicide compound as it did not show larvicidal or anticholinesterase activity. The data obtained suggest that the essential oil of Melaleuca alternifolia may have a great therapeutic potential for the treatment of human anisakiasis. PMID:24967378

  19. Optimised Post-Exposure Image Sharpening Code for L3-CCD Detectors

    SciTech Connect

    Harding, Leon K.; Butler, Raymond F.; Redfern, R. Michael; Sheehan, Brendan J.; McDonald, James

    2008-02-22

    As light from celestial bodies traverses Earth's atmosphere, the wavefronts are distorted by atmospheric turbulence, thereby lowering the angular resolution of ground-based imaging. Rapid time-series imaging enables Post-Exposure Image Sharpening (PEIS) techniques, which employ shift-and-add frame registration to remove the tip-tilt component of the wavefront error--as well as telescope wobble, thus benefiting all observations. Further resolution gains are possible by selecting only frames with the best instantaneous seeing--a technique sometimes calling 'Lucky Imaging'. We implemented these techniques in the 1990s, with the TRIFFID imaging photon-counting camera, and its associated data reduction software. The software was originally written for time-tagged photon-list data formats, recorded by detectors such as the MAMA. This paper describes our deep re-structuring of the software to handle the 2-d FITS images produced by Low Light Level CCD (L3-CCD) cameras, which have sufficient time-series resolution (>30 Hz) for PEIS. As before, our code can perform straight frame co-addition, use composite reference stars, perform PEIS under several different algorithms to determine the tip/tilt shifts, store 'quality' and shift information for each frame, perform frame selection, and generate exposure-maps for photometric correction. In addition, new code modules apply all 'static' calibrations (bias subtraction, dark subtraction and flat-fielding) to the frames immediately prior to the other algorithms. A unique feature of our PEIS/Lucky Imaging code is the use of bidirectional wiener-filtering. Coupled with the far higher sensitivity of the L3-CCD over the previous TRIFFID detectors, much fainter reference stars and much narrower time windows can be used.

  20. Future directions in clinical child and adolescent psychology: a Delphi survey.

    PubMed

    James, Rochelle L; Roberts, Michael C

    2009-10-01

    This study sought to identify the future directions in three domains: clinical practice, research, and training of clinical child and adolescent psychologists in the upcoming decade. Doctoral-level active members in the field were surveyed via a two-round Delphi survey (45 in round 1; 35 in round 2). Evidence-based practice received the greatest consensus by the participants and highest rank in each of the three domains. Other highly ranked clinical practice directions included prevention and early diagnosis and treatment, and clinical services for specific psychological problems. Research directions focused on biological and social factors interactions in the etiology and treatment and specific child and adolescent disorders. In the training domain, major directions included the pursuit of specialty training in child and adolescent psychology and training emphasizing the biological basis of behavior. Implications of these future directions are discussed.

  1. International mobility technology research: a Delphi study to identify challenges and compensatory strategies.

    PubMed

    Jefferds, Alexandra N; Pearlman, Jon L; Wee, Joy; Cooper, Rory A

    2011-01-01

    We sought to identify logistical and ethical challenges to performing wheelchair-related research in low- and middle-income countries and to generate a list of compensatory strategies to address these challenges. Thirteen individuals with experience in the field participated in an online Delphi study. The surveys asked participants to identify research challenges, suggest strategies to address the selected challenges, and critique each other's strategies. Participants identified challenges in the use of research techniques, compensation for participation that does not result coercion, oral and written translation materials, funding for research, collaboration with local professionals, and "respect for persons." Effective international mobility research requires time, cultural sensitivity, collaboration, and careful planning. An understanding of these requirements can allow researchers to anticipate and compensate for common pitfalls of their work, thus making the research more productive and beneficial to subjects. Future research is required to verify the general effectiveness of compensatory strategies.

  2. International mobility technology research: a Delphi study to identify challenges and compensatory strategies.

    PubMed

    Jefferds, Alexandra N; Pearlman, Jon L; Wee, Joy; Cooper, Rory A

    2011-01-01

    We sought to identify logistical and ethical challenges to performing wheelchair-related research in low- and middle-income countries and to generate a list of compensatory strategies to address these challenges. Thirteen individuals with experience in the field participated in an online Delphi study. The surveys asked participants to identify research challenges, suggest strategies to address the selected challenges, and critique each other's strategies. Participants identified challenges in the use of research techniques, compensation for participation that does not result coercion, oral and written translation materials, funding for research, collaboration with local professionals, and "respect for persons." Effective international mobility research requires time, cultural sensitivity, collaboration, and careful planning. An understanding of these requirements can allow researchers to anticipate and compensate for common pitfalls of their work, thus making the research more productive and beneficial to subjects. Future research is required to verify the general effectiveness of compensatory strategies. PMID:22256672

  3. Wilderness Emergency Medical Services Medical Director Course: core content developed with Delphi technique.

    PubMed

    Millin, Michael G; Hawkins, Seth; Demond, Anthony; Stiller, Gregory; McGinnis, Henderson D; Baker Rogers, Janna; Smith, William R

    2015-06-01

    The National Association of Emergency Medical Services Physicians' (NAEMSP) position on the role of medical oversight within an operational Emergency Medical Service (EMS) program highlights the importance of integrating specially trained medical directors within the structure of these programs. In response, the NAEMSP Wilderness EMS (WEMS) Committee recognized the need for the development of an educational curriculum to provide physicians with the unique skills needed to be a medical director for a WEMS agency. This paper describes the Delphi process used to create the subject matter core content, as well as the actual core content developed. This core content was the foundation for the development of a specific WEMS medical director curriculum, the Wilderness EMS Medical Director Course.

  4. Prerequisites to providing culturally competent care to Mexican migrant farmworkers: a Delphi study.

    PubMed

    Kim-Godwin, Yeoun Soo; Alexander, Judith W; Felton, Gwen; Mackey, Marlene C; Kasakoff, Alice

    2006-01-01

    The purpose of this study was to identify prerequisites to providing culturally competent care to Mexican migrant farmworkers. A national sample of nurse experts who worked with Mexican migrant farmworkers (N = 93 [50.2%] in round 1; and N = 142 [54.8%] in round 2) participated during the period of August 1998 to April 1999. Using a two-round modified Delphi method, a list of 89 items was generated. The nurse experts agreed that the 89 items identified were prerequisites to cultural competence, showing consensus rates of 85.4% in round 1 and 88.8% in round 2. The prerequisites to culturally competent care identified by participants encompassed caring, cultural sensitivity, cultural knowledge (general/specific), cultural abilities/skills, and others (bi-cultural status; cultural and learning experiences).

  5. Parenting to prevent body dissatisfaction and unhealthy eating patterns in preschool children: a Delphi consensus study.

    PubMed

    Hart, Laura M; Damiano, Stephanie R; Chittleborough, Philip; Paxton, Susan J; Jorm, Anthony F

    2014-09-01

    Interventions to prevent body dissatisfaction and unhealthy eating patterns are needed in early childhood. Identifying effective parenting strategies would be useful for parents and prevention researchers. To develop expert consensus, an online Delphi study was conducted with experts (N=28, Mage=44.34) who rated statements describing potential parenting strategies gleaned from a systematic literature search. If 90-100% rated a statement as either Essential or Important, it was endorsed as a guideline. From a total of 335 statements 153 were endorsed. Despite some areas of disagreement, including whether parents should weigh their child or discourage weighing, experts were able to reach consensus on a wide range of issues, such as how to discuss healthy eating with children. The developed guidelines provide a novel and required resource for parents, and a framework for researchers developing interventions to prevent the onset of body dissatisfaction and unhealthy eating patterns in early childhood. PMID:25084034

  6. Determination of problematic ICD-9-CM subcategories for further study of coding performance: Delphi method.

    PubMed

    Zeng, Xiaoming; Bell, Paul D

    2011-01-01

    In this study, we report on a qualitative method known as the Delphi method, used in the first part of a research study for improving the accuracy and reliability of ICD-9-CM coding. A panel of independent coding experts interacted methodically to determine that the three criteria to identify a problematic ICD-9-CM subcategory for further study were cost, volume, and level of coding confusion caused. The Medicare Provider Analysis and Review (MEDPAR) 2007 fiscal year data set as well as suggestions from the experts were used to identify coding subcategories based on cost and volume data. Next, the panelists performed two rounds of independent ranking before identifying Excisional Debridement as the subcategory that causes the most confusion among coders. As a result, they recommended it for further study aimed at improving coding accuracy and variation. This framework can be adopted at different levels for similar studies in need of a schema for determining problematic subcategories of code sets.

  7. Naturopathic Management of Females with Cervical Atypia: A Delphi Process to Explore Current Practice

    PubMed Central

    Leaver, Cynthia Ann; Miller-Davis, Claiborne; Wallen, Gwenyth R.

    2013-01-01

    Background Human papillomavirus is the most significant factor contributing to cervical cancer. Naturopathic doctors (NDs) implement an integrative approach to treat cervical atypia. This study explored practice consensus and variance among NDs. Methods A purposefully selected panel of six NDs participated in a modified Delphi study to validate practice. Three electronic web-based surveys were completed over nine months. Results Local and systemic treatments were included in all ND protocols. Six protocols included cervical cancer screening guidelines, green tea suppositories, and oral folic acid. Five protocols included oral green tea, diindoylemethane (DIM), and cartenoids. Four protocols incorporated Vitamin C. Two NDs considered escharotics when managing cervical atypia. All NDs included health behavior management in their protocols. Conclusion Naturopathic management of cervical atypia varies across practitioners. However, in general, elements of management include (1) cervical cancer screening guidelines, (2) local and systemic treatments, (3) health behavior/lifestyle recommendations, and (4) immune system support. PMID:23399786

  8. Core competencies for health professionals' training in pediatric behavioral sleep care: a Delphi study.

    PubMed

    Boerner, Katelynn E; Coulombe, J Aimée; Corkum, Penny

    2015-01-01

    The need to train non-sleep-specialist health professionals in evidence-based pediatric behavioral sleep care is well established. The objective of the present study was to develop a list of core competencies for training health professionals in assisting families of 1- to 10-year old children with behavioral insomnia of childhood. A modified Delphi methodology was employed, involving iterative rounds of surveys that were administered to 46 experts to obtain consensus on a core competency list. The final list captured areas relevant to the identification and treatment of pediatric behavioral sleep problems. This work has the potential to contribute to the development of training materials to prepare non-sleep-specialist health professionals to identify and treat pediatric behavioral sleep problems, ideally within stepped-care frameworks.

  9. Which are the best information sources for identifying emerging health care technologies? An international Delphi survey.

    PubMed

    Robert, G; Gabbay, J; Stevens, A

    1998-01-01

    The purpose of this survey was to assess potential information sources for identifying new health care technologies. A three-round Delphi study was conducted, involving 38 selected experts who suggested and assessed potential sources by applying agreed criteria. Twenty-six potential information sources were considered. Timeliness, time efficiency, and sensitivity were important criteria in determining which were the most important sources. The eight recommended sources were: pharmaceutical journals, pharmaceutical and biotechnology companies, specialist medical journals, key medical journals, medical engineering companies, private health care providers, newsletters and bulletins from other health technology assessment agencies, and groups of expert health professionals. There is a need to use a combination of sources because the most useful sources will vary according to the type of technology under consideration.

  10. A national Delphi to determine developmental progression of quality and safety competencies in nursing education.

    PubMed

    Barton, Amy J; Armstrong, Gail; Preheim, Gayle; Gelmon, Sherril B; Andrus, Lynne C

    2009-01-01

    Quality and Safety Education for Nurses (QSEN) faculty outlined 6 competency domains: patient-centered care, teamwork and collaboration, evidence-based practice, quality improvement, safety, and informatics. In this study, 18 subject matter experts participated in a web-based modified Delphi survey between October 2008 and February 2009 to determine whether there was consensus on the developmental progression of knowledge, skill, and attitude elements within the QSEN competencies. Support for creation of curricular threads to facilitate student progressive achievement of the QSEN competencies was validated. Competency development related to the individual patient was emphasized early in the curriculum, whereas teams and systems were emphasized later. Complex concepts such as teamwork and collaboration, evidence-based practice, quality improvement, and informatics were emphasized in advanced courses. Experts outlined a developmental approach in curriculum design, which would potentially encourage practice, reinforcement of learning, and recognition of context of care.

  11. The DELPHI Hadron Calorimeter module characteristics in the saturated proportional mode of its detector operation

    NASA Astrophysics Data System (ADS)

    Filatova, N. A.; Gotra, Yu. N.; Kadyrov, R. B.; Pozdnyakov, V. N.; Ryzhov, V. N.; Sadovsky, A. B.; Spassov, Tz.; Timofeev, V. G.; Tsyganov, E. N.; Tyapkin, I. A.; Vodopianov, A. S.; Zimin, N. I.; Zinchenko, A. I.

    1989-07-01

    A preamplifier allowing an increase in the sensitivity of the already produced DELPHI Hadron Calorimeter front-end electronics up to 0.1 pC is described. The presented preamplifier permits a considerable reduction of the gas gain and transition to the saturated avalanche mode region. The HC barrel module characteristics in the proportional mode of its detector operation are explored. The possibility of selecting muon tracks in the HC and using them for detector triggering has been investigated. It is shown that the transition to the proportional mode does not worsen the main characteristics of the HC and the reliability of its detectors will be considerably increased. The investigation has been performed at the Laboratory of High Energies, JINR.

  12. Needs assessment for training in interprofessional skills in Swiss primary care: a Delphi study.

    PubMed

    Junod Perron, Noelle; Cerutti, Bernard; Picchiottino, Patricia; Empeyta, Sebastien; Cinter, Francoise; van Gessel, Elisabeth

    2014-05-01

    Despite the importance of appropriate interprofessional collaboration in health care, it is still insufficiently taught in health professions education. The aim of the study was to conduct a needs assessment among health professionals on the themes and skills to be taught during interprofessional education programs in the context of Swiss primary care. A three round Delphi electronic survey was carried out in order to identify priority themes and skills to be included in such a program. Participants comprised 12 categories of health professionals. Seventy-two participated in the first, 41 in the second and 43 in the third round. Patient communication, case management of chronic conditions, therapeutic patient education, health promotion and prevention, ethics and medication were the most important themes identified. The most important skill was regarded as "to define and then share tasks and responsibilities between professionals". Sub-analysis revealed that both priority themes and skills chosen differed between health professional categories.

  13. Perspectives on academic health sciences libraries in the 1980s: indicators from a Delphi study.

    PubMed Central

    Matheson, N W

    1982-01-01

    A Delphi study was undertaken to identify the changes in library roles and functions that the directors of academic health sciences libraries believe will occur over the next decade. The methodology is described and the results are summarized. Two scenarios resulted: one, highly desirable; the other, highly probable. They overlap by 64%. Library directors expect moderate evolutionary changes in the next ten years. Users are perceived to be the force maintaining the status quo, while technology is the force advancing change. The adoption of technology is seen as desirable and within the libraries' span of control. Education and service roles of librarians will expand. Library and institutional priorities are seen as obstacles to change. PMID:7037086

  14. Identifying the critical financial ratios for stocks evaluation: A fuzzy delphi approach

    NASA Astrophysics Data System (ADS)

    Mokhtar, Mazura; Shuib, Adibah; Mohamad, Daud

    2014-12-01

    Stocks evaluation has always been an interesting and challenging problem for both researchers and practitioners. Generally, the evaluation can be made based on a set of financial ratios. Nevertheless, there are a variety of financial ratios that can be considered and if all ratios in the set are placed into the evaluation process, data collection would be more difficult and time consuming. Thus, the objective of this paper is to identify the most important financial ratios upon which to focus in order to evaluate the stock's performance. For this purpose, a survey was carried out using an approach which is based on an expert judgement, namely the Fuzzy Delphi Method (FDM). The results of this study indicated that return on equity, return on assets, net profit margin, operating profit margin, earnings per share and debt to equity are the most important ratios.

  15. Meningoencephalitis and arthritis associated with Brucella ceti in a short-beaked common dolphin (Delphinus delphis).

    PubMed

    Davison, Nicholas J; Barnett, James E F; Perrett, Lorraine L; Dawson, Claire E; Perkins, Matthew W; Deaville, Robert C; Jepson, Paul D

    2013-07-01

    Brucella species infection in marine mammal species has been reported to have a global distribution. In 2007, the description of Brucella ceti was published and formally adopted for those isolates originating from cetaceans and pathologic lesions similar to those seen in terrestrial mammals infected with Brucella spp. have been associated with its isolation. Brucella ceti infection specific to the central nervous system has been described in two species of cetacean: striped dolphins (Stenella coeruleoalba) in Europe and Costa Rica and an Atlantic white-sided dolphin (Lagenorhynchus acutus) in the UK. We describe the first report, to our knowledge, of B. ceti-associated meningitis and arthritis in a third species, the short-beaked common dolphin (Delphinus delphis), in an animal that stranded in the UK. PMID:23778612

  16. [Retrospective evaluation of occupational exposure in epidemiologic studies. Use of the Delphi method].

    PubMed

    Goldberg, M; Leclerc, A; Chastang, J F; Goldberg, P; Brodeur, J M; Fuhrer, R; Segnan, N

    1986-01-01

    A method, based on the Delphi technique, for evaluating occupational risks in a quantifiable manner was devised in the course of a case-control study on respiratory cancers in the nickel mining and refining industry in New Caledonia. There were four stages in the evaluation process: identification of eleven potential carcinogenic factors in the company during the 1930-1977 period; grouping of a limited number of work-stations; evaluation of exposure levels for the different factors for each workstation; computation of the cumulative value of exposure for each subject under study. A partial validation study shows that this kind of approach may prove useful for future occupational epidemiological studies. PMID:3547516

  17. Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.

    PubMed

    Schmiegelow, Kjeld; Attarbaschi, Andishe; Barzilai, Shlomit; Escherich, Gabriele; Frandsen, Thomas Leth; Halsey, Christina; Hough, Rachael; Jeha, Sima; Kato, Motohiro; Liang, Der-Cherng; Mikkelsen, Torben Stamm; Möricke, Anja; Niinimäki, Riitta; Piette, Caroline; Putti, Maria Caterina; Raetz, Elizabeth; Silverman, Lewis B; Skinner, Roderick; Tuckuviene, Ruta; van der Sluis, Inge; Zapotocka, Ester

    2016-06-01

    Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects. This is because reported frequencies vary widely across studies, partly because of diverse definitions of toxic effects. Using the Delphi method, 15 international childhood acute lymphoblastic leukaemia study groups assessed acute lymphoblastic leukaemia protocols to address toxic effects that were to be considered by the Ponte di Legno working group. 14 acute toxic effects (hypersensitivity to asparaginase, hyperlipidaemia, osteonecrosis, asparaginase-associated pancreatitis, arterial hypertension, posterior reversible encephalopathy syndrome, seizures, depressed level of consciousness, methotrexate-related stroke-like syndrome, peripheral neuropathy, high-dose methotrexate-related nephrotoxicity, sinusoidal obstructive syndrome, thromboembolism, and Pneumocystis jirovecii pneumonia) that are serious but too rare to be addressed comprehensively within any single group, or are deemed to need consensus definitions for reliable incidence comparisons, were selected for assessment. Our results showed that none of the protocols addressed all 14 toxic effects, that no two protocols shared identical definitions of all toxic effects, and that no toxic effect definition was shared by all protocols. Using the Delphi method over three face-to-face plenary meetings, consensus definitions were obtained for all 14 toxic effects. In the overall assessment of outcome of acute lymphoblastic leukaemia treatment, these expert opinion-based definitions will allow reliable comparisons of frequencies and severities of acute toxic effects across treatment protocols, and facilitate international research on cause, guidelines for treatment adaptation, preventive strategies, and development of consensus algorithms for reporting on acute lymphoblastic leukaemia treatment. PMID:27299279

  18. Using a Delphi process to define priorities for prison health research in Canada

    PubMed Central

    Kouyoumdjian, Fiona G; Schuler, Andrée; McIsaac, Kathryn E; Pivnick, Lucie; Matheson, Flora I; Brown, Glenn; Kiefer, Lori; Silva, Diego; Hwang, Stephen W

    2016-01-01

    Objectives A large number of Canadians spend time in correctional facilities each year, and they are likely to have poor health compared to the general population. Relatively little health research has been conducted in Canada with a focus on people who experience detention or incarceration. We aimed to conduct a Delphi process with key stakeholders to define priorities for research in prison health in Canada for the next 10 years. Setting We conducted a Delphi process using an online survey with two rounds in 2014 and 2015. Participants We invited key stakeholders in prison health research in Canada to participate, which we defined as persons who had published research on prison health in Canada since 1994 and persons in the investigators’ professional networks. We invited 143 persons to participate in the first round and 59 participated. We invited 137 persons to participate in the second round and 67 participated. Primary and secondary outcome measures Participants suggested topics in the first round, and these topics were collated by investigators. We measured the level of agreement among participants that each collated topic was a priority for prison health research in Canada for the next 10 years, and defined priorities based on the level of agreement. Results In the first round, participants suggested 71 topics. In the second round, consensus was achieved that a large number of suggested topics were research priorities. Top priorities were diversion and alternatives to incarceration, social and community re-integration, creating healthy environments in prisons, healthcare in custody, continuity of healthcare, substance use disorders and the health of Aboriginal persons in custody. Conclusions Generated in an inclusive and systematic process, these findings should inform future research efforts to improve the health and healthcare of people who experience detention and incarceration in Canada. PMID:26769790

  19. Delphi Consensus Recommendations: Intraoperative Technique and Postoperative Management of Patients with Natrelle 410 Implants

    PubMed Central

    Brown, Mitchell H.; Hedén, Per; Luan, Jie; Munhoz, Alexandre Mendonça; Carter, Mollie

    2015-01-01

    Background: Anatomically shaped, form-stable Natrelle 410 breast implants were approved in Europe in 1993 and in the United States in 2013. Although general guidelines for breast augmentation are available, the distinctive characteristics of Natrelle 410 warrant specific guidelines for this device. The goal of this study was to generate consensus recommendations for intraoperative technique and postoperative management with Natrelle 410 in primary breast augmentation. Methods: Surgeons were invited to participate in the study, which used a modified Delphi method. Participants completed 2 rounds of online surveys; the second survey (Recommendations Survey) was generated based on first survey results. Respondents also listed top priorities for use of Natrelle 410. Results: Participants (n = 22) reached consensus on 15 of 18 perioperative and surgical techniques; dual-plane placement, tight pockets, and limiting the boundaries of dissection were among intraoperative techniques considered most important for Natrelle 410. Consensus was reached for 18 of 32 items regarding postoperative management and 6 of 9 open-ended postoperative activity restrictions. Consensus on activity restrictions with specified time limits were similar to consensus recommendations on general restrictions. Top participant-identified intraoperative and postoperative management practices for Natrelle 410 were dual-plane placement of the implant and wearing a bra postoperatively, respectively. Conclusions: The Delphi method identified consensus recommendations on a broad range of intraoperative techniques and postoperative management practices for primary breast augmentation with Natrelle 410. These recommendations and priorities provide surgeons with a framework that, together with the surgeon’s experience, will contribute to optimal clinical outcomes with Natrelle 410. PMID:26893982

  20. Identification of the critical elements of environmental literacy: A Delphi study

    NASA Astrophysics Data System (ADS)

    Hoffmann, Johannes Oswald

    The overall purpose of this study was to obtain the opinions of environmental experts regarding the three identified levels of environmental literacy: nominal, functional, and operational. Specifically, this study was performed to identify and rank for importance the critical elements of environmental literacy as perceived by practicing environmental professionals. The Delphi technique was utilized to identify and refine the critical elements of environmental literacy by eliciting the opinions of experts in the environmental field. The research was conducted as a two-phase project. Phase I employed environmental experts who were Certified Environmental Professionals (CEPs) of the National Association of Environmental Professionals. In Phase II, the elements identified by Panel I were compared with the opinions elicited from Panel II, a group of managers and educators from Texas. Median scores were used to rank the elements. Elements meeting the criteria for inclusion became the final list of critical elements. The results of this study revealed that of the 79 critical elements of environmental literacy suggested by research sources and Panel I, 59 were rated for inclusion in the final list of elements. A significant difference (p < .05) was found for only 10 of the 79 elements by Panel II. Research involving environmental problems and issues indicated that in order for environmental-education programs to be successful, environmental literacy must be clearly identified and defined. As a statement of group opinion among a national panel of practicing environmental professionals, the Delphi technique produced a list of 59 critical elements of environmental literacy, and the importance of each element was determined by the use of the median. A comparison of results between Rounds 2 and 3 and the follow-up study revealed limited significant differences in median ratings. It was concluded that the final list of elements and their rankings represent the opinions of

  1. Mental Health First Aid guidelines for helping a suicidal person: a Delphi consensus study in India

    PubMed Central

    2010-01-01

    Background This study aimed to develop guidelines for how a member of the Indian public should provide mental health first aid to a person who is suicidal. Methods The guidelines were produced by developing a questionnaire containing possible first aid actions and asking an expert panel of Indian mental health clinicians to rate whether each action should be included in the guidelines. The content of the questionnaire was based on a systematic search of the relevant evidence and claims made by authors of consumer and carer guides and websites. Experts were recruited by SC, EC and HM. The panel members were asked to complete the questionnaire by web survey. Three rounds of the rating were carried and, at the end of each round, items that reached the consensus criterion were selected for inclusion in the guidelines. During the first round, panel members were also asked to suggest any additional actions that were not covered in the original questionnaire (to include items that are relevant to local cultural circumstances, values, and social norms.). Responses to the open-ended questions were used to generate new items. Results The output from the Delphi process was a set of agreed upon action statements. The Delphi process started with 138 statements, 30 new items were written based on suggestions from panel members and, of these 168 items, 71 met the consensus criterion. These statements were used to develop the guidelines appended to this paper. Translated versions of the guidelines will be produced and used for training. Conclusions There are a number of actions that are considered to be useful for members of the public when they encounter someone who is experiencing suicidal thoughts or engaging in suicidal behaviour. Although the guidelines are designed for members of the public, they may also be helpful to non-mental health professionals working in health and welfare settings. PMID:20167125

  2. Mental Health First Aid guidelines for helping a suicidal person: a Delphi consensus study in Japan

    PubMed Central

    2011-01-01

    Background This study aimed to develop guidelines for how a member of the Japanese public should provide mental health first aid to a person who is suicidal. Methods The guidelines were produced by developing a questionnaire containing possible first aid actions and asking an expert panel of 32 Japanese mental health professionals to rate whether each action should be included in the guidelines. The content of the questionnaire was based on a systematic search of the relevant evidence and claims made by authors of consumer and carer guides and websites. The panel members were asked to complete the questionnaire by web survey. Three rounds of the rating were carried and, at the end of each round, items that reached the consensus criterion were selected for inclusion in the guidelines. During the first round, panel members were also asked to suggest any additional actions that were not covered in the original questionnaire (to include items that are relevant to local cultural circumstances, values, and social norms). Responses to these open-ended questions were used to generate new items. Results The output from the Delphi process was a set of agreed upon action statements. The Delphi process started with 138 statements, 38 new items were written based on suggestions from panel members and, of these 176 items, 56 met the consensus criterion. These statements were used to develop the guidelines appended to this article. Conclusions There are a number of actions that are considered to be useful for members of the Japanese public when they encounter someone who is experiencing suicidal thoughts or engaging in suicidal behaviour. Although the guidelines are designed for members of the public, they may also be helpful to health professionals working in health and welfare settings who do not have clinical mental health training. PMID:21592409

  3. Using the Delphi and Snow Card Techniques to Build Consensus Among Diverse Community and Academic Stakeholders

    PubMed Central

    Rideout, Catlin; Gil, Rosa; Browne, Ruth; Calhoon, Claudia; Rey, Mariano; Gourevitch, Marc; Trinh-Shevrin, Chau

    2013-01-01

    Background: The New York University– New York City Health and Hospitals Corporation (NYU-HHC) Clinical and Translational Science Institute (CTSI) used a community-based participatory research (CBPR) and consensus-building approach among its community advisory board (CAB) and steering committee (SC) members to formulate research priorities to foster shared research collaborations. Methods: The Delphi technique is a methodology used to generate consensus from diverse perspectives and organizational agendas through a multi-method, iterative approach to collecting data. A series of on-line surveys was conducted with CAB members to identify health and research priorities from the community perspective. Subsequently, CAB and SC members were brought together and the snow card approach was utilized to narrow to two priority areas for shared research collaborations. Results: Cardiovascular disease (CVD)/obesity and mental health were identified as health disparity areas for shared research collaborations within a social determinants framework. In response, two workgroups were formed with leadership provided by three co-chairs representing the three constituents of the NYU-HHC CTSI: NYU faculty, HHC providers, and community leaders Conclusions: The Delphi approach fostered ownership and engagement with community partners because it was an iterative process that required stakeholders’ input into decision making. The snow card technique allowed for organizing of a large number of discrete ideas. Results have helped to inform the overall CTSI research agenda by defining action steps, and setting an organizing framework to tackle two health disparity areas. The process helped ensure that NYUHHC CTSI research and community engagement strategies are congruent with community priorities.

  4. Terminology, Taxonomy, and Facilitation of Motor Learning in Clinical Practice: Protocol of a Delphi Study

    PubMed Central

    Bleijlevens, Michel HC; Beurskens, Anna JHM; Rasquin, Sascha M; Halfens, Jos; Wilson, Mark R; Masters, Rich S; Lexis, Monique A; Braun, Susy M

    2013-01-01

    Background Facilitating motor learning in patients during clinical practice is complex, especially in people with cognitive impairments. General principles of motor learning are available for therapists to use in their practice. However, the translation of evidence from the different fields of motor learning for use in clinical practice is problematic due to lack of uniformity in definition and taxonomy of terms related to motor learning. Objective The objective of this paper was to describe the design of a Delphi technique to reach consensus on definitions, descriptions, and taxonomy used within motor learning and to explore experts’ opinions and experiences on the application of motor learning in practice. Methods A heterogeneous sample of at least 30 international experts on motor learning will be recruited. Their opinions regarding several central topics on motor learning using a Delphi technique will be collected in 3 sequential rounds. The questionnaires in the 3 rounds will be developed based on the literature and answers of experts from earlier rounds. Consensus will be reached when at least 70% of the experts agree on a certain topic. Free text comments and answers from open questions on opinions and experiences will be described and clustered into themes. Results This study is currently ongoing. It is financially supported by Stichting Alliantie Innovatie (Innovation Alliance Foundation), RAAK-international (Registration number: 2011-3-33int). Conclusions The results of this study will enable us to summarize and categorize expert knowledge and experiences in a format that should be more accessible for therapists to use in support of their clinical practice. Unresolved aspects will direct future research. PMID:23685621

  5. Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs

    PubMed Central

    Huisman, Christian; van der Wijst, Monique GP; Falahi, Fahimeh; Overkamp, Juul; Karsten, Gellért; Terpstra, Martijn M; Kok, Klaas; van der Zee, Ate GJ; Schuuring, Ed; Wisman, G Bea A; Rots, Marianne G

    2015-01-01

    Epigenetic silencing of tumor suppressor genes (TSGs) is considered a significant event in the progression of cancer. For example, EPB41L3, a potential biomarker in cervical cancer, is often silenced by cancer-specific promoter methylation. Artificial transcription factors (ATFs) are unique tools to re-express such silenced TSGs to functional levels; however, the induced effects are considered transient. Here, we aimed to improve the efficiency and sustainability of gene re-expression using engineered zinc fingers fused to VP64 (ZF-ATFs) or DNA methylation modifiers (ZF-Tet2 or ZF-TDG) and/or by co-treatment with epigenetic drugs [5-aza-2′-deoxycytidine or Trichostatin A (TSA)]. The EPB41L3-ZF effectively bound its methylated endogenous locus, as also confirmed by ChIP-seq. ZF-ATFs reactivated the epigenetically silenced target gene EPB41L3 (∼10-fold) in breast, ovarian, and cervical cancer cell lines. Prolonged high levels of EPB41L3 (∼150-fold) induction could be achieved by short-term co-treatment with epigenetic drugs. Interestingly, for otherwise ineffective ZF-Tet2 or ZF-TDG treatments, TSA facilitated re-expression of EPB41L3 up to twofold. ATF-mediated re-expression demonstrated a tumor suppressive role for EPB41L3 in cervical cancer cell lines. In conclusion, epigenetic reprogramming provides a novel way to improve sustainability of re-expression of epigenetically silenced promoters. PMID:25830725

  6. Characterizing substrate selectivity of ubiquitin C-terminal hydrolase-L3 using engineered α-linked ubiquitin substrates.

    PubMed

    Navarro, Mario F; Carmody, Lisa; Romo-Fewell, Octavio; Lokensgard, Melissa E; Love, John J

    2014-12-30

    The ubiquitin-proteasome system (UPS) is highly complex and entails the concerted actions of many enzymes that function to ubiquitinate proteins targeted to the proteasome as well as enzymes that remove and recycle ubiquitin for additional rounds of proteolysis. Ubiquitin C-terminal hydrolase-L3 (UCH-L3) is a human cytosolic deubiquitinase whose precise biological function is not known. It is believed to hydrolyze small peptides or chemical adducts from the C-terminus of ubiquitin that may be remnant from proteasomal processing. In addition, UCH-L3 is a highly effective biotechnological tool that is used to produce small or unstable peptides/proteins recalcitrant to production in Escherichia coli expression systems. Previous research, which explored the substrate selectivity of UCH-L3, demonstrated a substrate size limitation for proteins/peptides expressed as α-linked C-terminal fusions to ubiquitin and also suggested that an additional substrate property may affect UCH-L3 hydrolysis [ Larsen , C. N. et al. (1998) Biochemistry 37 , 3358 - 3368 ]. Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis. In addition, we show that the thermal stabilities of the engineered substrates are not altered by fusion to ubiquitin and offer a possible mechanism as to how ubiquitin affects the structural and unfolding properties of natural in vivo targets.

  7. Essential Concepts of Nanoscale Science and Technology for High School Students Based on a Delphi Study by the Expert Community

    NASA Astrophysics Data System (ADS)

    Sakhnini, Sohair; Blonder, Ron

    2015-07-01

    Nanoscale science and technology (NST) is an important new field in modern science. In the current study, we seek to answer the question: 'What are the essential concepts of NST that should be taught in high school'? A 3-round Delphi study methodology was applied based on 2 communities of experts in nanotechnology research and science education. Eight essential concepts in NST were identified. Each concept is accompanied by its explanation, definition, importance and includes subcategories that compose it. Three concepts emerged in the Delphi study, which were not identified before: functionality, classification of nanomaterials, and the making of nanotechnology. Differences between the concepts suggested by the 2 communities of experts were found. The results of this study serve as a tool to examine different nanotechnology programs that were reported thus far and to make recommendations for designing a NST program for high school students that includes the essential concepts.

  8. Evidence-based development of a post-surgical lumbar discectomy leaflet intervention: a Delphi consensus study

    PubMed Central

    Goodwin, P C; Wright, C C; Allan, C; Crowther, L; Darley, C; Heap, A; Paul, E; White, L; Rushton, A

    2015-01-01

    Objective To produce free, expert-informed postoperative information for lumbar discectomy patients, satisfying UK National Health Service Information Standards. Design A mixed methods approach utilising the Delphi technique and focus groups. Setting Five spinal centres across the UK. Participants Panel members included 23 physiotherapists, 11 patients and 17 spinal surgeons. Intervention Three rounds of questionnaires including open and closed questions and attendance at a clinician/patient focus group. Results Response rates of 85%, 26% and 35% were achieved for the Delphi rounds. Ten clinicians and six patients participated in the focus groups. Consensus for leaflet sections was achieved in round 1 and content in round 3. The focus groups informed further revisions. Conclusions A consensually agreed, Information Standard compliant, patient lumbar discectomy leaflet was produced containing: (1) normal spine anatomy; (2) anatomy disc herniation and surgery; (3) back protection strategies and (4) frequently asked questions. Illustrations of exercises enable tailoring to the individual patient. PMID:25762227

  9. Small bowel entrapment and ureteropelvic junction disruption associated with L3 Chance fracture-dislocation.

    PubMed

    Pesenti, Sebastien; Blondel, Benjamin; Faure, Alice; Peltier, Emilie; Launay, Franck; Jouve, Jean-Luc

    2016-09-16

    Paediatric Chance fracture are rare lesions but often associated with abdominal injuries. We herein present the case of a seven years old patient who sustained an entrapment of small bowel and an ureteropelvic disruption associated with a Chance fracture and spine dislocation following a traffic accident. Initial X-rays and computed tomographic (CT) scan showed a Chance fracture with dislocation of L3 vertebra, with an incarceration of a small bowel loop in the spinal canal and a complete section of the left lumbar ureter. Paraplegia was noticed on the initial neurological examination. A posterior L2-L4 osteosynthesis was performed firstly. In a second time she underwent a sus umbilical laparotomy to release the incarcerated jejunum loop in the spinal canal. An end-to-end anastomosis was performed on a JJ probe to suture the left injured ureter. One month after the traumatism, she started to complain of severe headaches related to a leakage of cerebrospinalis fluid. Three months after the traumatism there was a clear regression of the leakage. One year after the trauma, an anterior intervertebral fusion was done. At final follow-up, no neurologic recovery was noticed. In case of Chance fracture, all physicians should think about abdominal injuries even if the patient is asymptomatic. Initial abdominal CT scan and magnetic resonance imaging provide in such case crucial info for management of the spine and the associated lesions. PMID:27672641

  10. Small bowel entrapment and ureteropelvic junction disruption associated with L3 Chance fracture-dislocation

    PubMed Central

    Pesenti, Sebastien; Blondel, Benjamin; Faure, Alice; Peltier, Emilie; Launay, Franck; Jouve, Jean-Luc

    2016-01-01

    Paediatric Chance fracture are rare lesions but often associated with abdominal injuries. We herein present the case of a seven years old patient who sustained an entrapment of small bowel and an ureteropelvic disruption associated with a Chance fracture and spine dislocation following a traffic accident. Initial X-rays and computed tomographic (CT) scan showed a Chance fracture with dislocation of L3 vertebra, with an incarceration of a small bowel loop in the spinal canal and a complete section of the left lumbar ureter. Paraplegia was noticed on the initial neurological examination. A posterior L2-L4 osteosynthesis was performed firstly. In a second time she underwent a sus umbilical laparotomy to release the incarcerated jejunum loop in the spinal canal. An end-to-end anastomosis was performed on a JJ probe to suture the left injured ureter. One month after the traumatism, she started to complain of severe headaches related to a leakage of cerebrospinalis fluid. Three months after the traumatism there was a clear regression of the leakage. One year after the trauma, an anterior intervertebral fusion was done. At final follow-up, no neurologic recovery was noticed. In case of Chance fracture, all physicians should think about abdominal injuries even if the patient is asymptomatic. Initial abdominal CT scan and magnetic resonance imaging provide in such case crucial info for management of the spine and the associated lesions. PMID:27672641

  11. Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization

    PubMed Central

    Wang, Meijiao; Yu, Tinghe; Hu, Lina; Cheng, Zhi; Li, Min

    2016-01-01

    Ubiquitin C-terminal hydrolase L3 (UCHL3) belongs to the group of deubiquitinating enzymes and plays a part in apoptosis of germ cells and the differentiation of spermatocytes into spermatids. However, the exact role of UCHL3 in human spermatogenesis and sperm function remains unknown. Here we examined the level and activity of UCHL3 in spermatozoa from men with asthenozoospermia (A), oligoasthenozoospermia (OA) or normozoospermia (N). Immunofluorescence indicated that UCHL3 was mainly localized in the acrosome and throughout the flagella, and western blotting revealed a lower level in A or OA compared with N (p < 0.05). The catalytic activity of UCHL3 was decreased in spermatozoa from A or OA (p < 0.05, p < 0.001, respectively). The level and activity of UCHL3 were positively correlated with sperm count, concentration and motility. The UCHL3 level was positively correlated with the normal fertilization rate (FR) and percentage of embryos suitable for transfer/cryopreservation of in vitro fertilization (IVF). The UCHL3 activity was also positively correlated with FR, the percentage of embryos suitable for transfer/cryopreservation and high-quality embryos rate of IVF. Aforementioned correlations were not manifested in intra-cytoplasmic sperm injection (ICSI). These findings suggest that UCHL3 may play a role in male infertility. PMID:27780264

  12. Valence determination of rare earth elements in lanthanide silicates by L 3-XANES spectroscopy

    NASA Astrophysics Data System (ADS)

    Kravtsova, Antonina N.; Guda, Alexander A.; Goettlicher, Joerg; Soldatov, Alexander V.; Taroev, Vladimir K.; Kashaev, Anvar A.; Suvorova, Lyudmila F.; Tauson, Vladimir L.

    2016-05-01

    Lanthanide silicates have been hydrothermally synthesized using Cu and Ni containers. Chemical formulae of the synthesized compounds correspond to K3Eu[Si6O15] 2H2O, HK6Eu[Si10O25], K7Sm3[Si12O32], K2Sm[AlSi4O12] 0.375H2O, K4Yb2[Si8O21], K4Ce2[Al2Si8O24]. The oxidation state of lanthanides (Eu, Ce, Tb, Sm, Yb) in these silicates has been determined using XANES spectroscopy at the Eu, Ce, Tb, Sm, Yb, L 3- edges. The experimental XANES spectra were recorded using the synchrotron radiation source ANKA (Karlsruhe Institute of Technology) and the X-ray laboratory spectrometer Rigaku R- XAS. By comparing the absorption edge energies and white line intensities of the silicates with the ones of reference spectra the oxidation state of lanthanides Eu, Ce, Tb, Sm, Yb has been found to be equal to +3 in all investigated silicates except of the Ce-containing silicate from the run in Cu container where the cerium oxidation state ranges from +3 (Ce in silicate apatite and in a KCe silicate with Si12O32 layers) to +4 (starting CeO2 or oxidized Ce2O3).

  13. Observation of Δ| k - l| = 3 Transitions in the ν 3Band of H 3O +

    NASA Astrophysics Data System (ADS)

    Uy, D.; White, E. T.; Oka, T.

    1997-06-01

    Although the vibration-rotation spectrum of H3O+has been studied extensively, there has been no experimental information on the value of theCrotational constant because of the absence of any observed Δ|k - l| ≠ 0 forbidden transitions. However, as pointed out by Verhoeveet al.in their far-infrared spectroscopic work [P. Verhoeve, M. Versluis, J. J. Ter Meulen, W. L. Meerts, and A. Dynamus,Chem. Phys. Lett.161,195-201 (1989)], a near degeneracy exists between some (J, 0)+and (J, 3)-ground state rotation-inversion levels, which causes sizable shifts in these levels due to off-diagonal centrifugal distortion. These shifts were observed in the ground state combination differences of the ν3fundamental transitions. We have observed 11 forbidden Δ|k - l| = 3 transitions to the ν3band induced by the mixing in the ground state and involving theJ= 7, 9, and 11 levels, and determined the energy difference between differentKlevels, theCrotational constant, and the off-diagonal centrifugal distortion mixing coefficient.

  14. Activity of Tea Tree (Melaleuca alternifolia) Essential Oil against L3 Larvae of Anisakis simplex

    PubMed Central

    Langa, Elisa; Murillo, Paula

    2014-01-01

    Nematicidal activity of Melaleuca alternifolia essential oil, commonly known as tea tree oil (TTO), was assayed in vitro against L3 larvae of Anisakis simplex. The results showed a mortality of 100% for concentrations between 7 and 10 μL/mL after 48 h of incubation, obtaining an LD50 value of 4.53 μL/mL after 24 hours and 4.27 μL/mL after 48 hours. Concentration-dependent inhibition of acetylcholinesterase was observed for tea tree essential oil showing inhibition values of 100% at 100 μL/mL. This fact suggests that TTO may act as an AChE inhibitor. Terpinen-4-ol was discarded as main larvicide compound as it did not show larvicidal or anticholinesterase activity. The data obtained suggest that the essential oil of Melaleuca alternifolia may have a great therapeutic potential for the treatment of human anisakiasis. PMID:24967378

  15. A turn-key Concept for active cancellation of Global Positioning System L3 Signal

    NASA Astrophysics Data System (ADS)

    Nigra, Lou; Lewis, B. M.; Edgar, C. E.; Perillat, P.; Quintero, L.; Stanimirovic, S.; Gallagher, J. S., III

    2011-01-01

    We present a concept, developed at the National Astronomy and Ionosphere Center (NAIC) at Arecibo, Puerto Rico, for suppression of Global Positioning System (GPS) signals in the 305 m dish radio receiver path prior to backend processing. The subsystem does not require an auxiliary antenna and is intended for easy integration with radio telescope systems with a goal of being a turnkey addition to virtually any facility. We have focused on detection and cancellation of the GPS L3 signal at 1381.05 MHz which, during periodic test modes and particularly during system-wide tests, interfere with observations of objects in a range of redshifts that includes the Coma supercluster, for example. The signal can dynamically change modulation modes and our scheme has demonstrated, through simulations using actual sampled telescope data, the ability to acquire and track these signals as well as detect the mode changes in order to apply cancellation or blanking, as appropriate. The subsystem can also be adapted to GPS L1 (1575.42 MHz), L2C (1227.6 MHz), and others. A follow-up is underway to develop a prototype to deploy and evaluate at NAIC.

  16. Ultralow bias power all-optical photonic crystal memory realized with systematically tuned L3 nanocavity

    SciTech Connect

    Kuramochi, Eiichi Nozaki, Kengo; Shinya, Akihiko; Taniyama, Hideaki; Notomi, Masaya; Takeda, Koji; Matsuo, Shinji; Sato, Tomonari

    2015-11-30

    An InP photonic crystal nanocavity with an embedded InGaAsP active region is a unique technology that has realized an all-optical memory with a sub-micro-watt operating power and limitless storage time. In this study, we employed an L3 design with systematic multi-hole tuning, which realized a higher loaded Q factor (>40 000) and a lower mode volume (0.9 μm{sup 3}) than a line-defect-based buried-heterostructure nanocavity (16 000 and 2.2 μm{sup 3}). Excluding the active region realized a record loaded Q factor (210 000) in all for InP-based nanocavities. The minimum bias power for bistable memory operation was reduced to 2.3 ± 0.3 nW, which is about 1/10 of the previous record of 30 nW. This work further established the capability of a bistable nanocavity memory for use in future ultralow-power-consumption on-chip integrated photonics.

  17. Active faulting at Delphi, Greece: Seismotectonic remarks and a hypothesis for the geologic environment of a myth

    NASA Astrophysics Data System (ADS)

    Piccardi, Luigi

    2000-07-01

    Historical data are fundamental to the understanding of the seismic history of an area. At the same time, knowledge of the active tectonic processes allows us to understand how earthquakes have been perceived by past cultures. Delphi is one of the principal archaeological sites of Greece, the main oracle of Apollo. It was by far the most venerated oracle of the Greek ancient world. According to tradition, the mantic proprieties of the oracle were obtained from an open chasm in the earth. Delphi is directly above one of the main antithetic active faults of the Gulf of Corinth Rift, which bounds Mount Parnassus to the south. The geometry of the fault and slip-parallel lineations on the main fault plane indicate normal movement, with minor right-lateral slip component. Combining tectonic data, archaeological evidence, historical sources, and a reexamination of myths, it appears that the Helice earthquake of 373 B.C. ruptured not only the master fault of the Gulf of Corinth Rift at Helice, but also the antithetic fault at Delphi, similarly to the Corinth earthquake of 1981. Moreover, the presence of an active fault directly below the temples of the oldest sanctuary suggests that the mythological oracular chasm might well have been an ancient tectonic surface rupture.

  18. A web-based delphi study for eliciting helpful criteria in the positive diagnosis of hemophagocytic syndrome in adult patients.

    PubMed

    Hejblum, Gilles; Lambotte, Olivier; Galicier, Lionel; Coppo, Paul; Marzac, Christophe; Aumont, Cédric; Fardet, Laurence

    2014-01-01

    The diagnosis of the reactive form of hemophagocytic syndrome in adults remains particularly difficult since none of the clinical or laboratory manifestations are specific. We undertook a study in order to elicit which features constitute helpful criteria for a positive diagnosis. In this Delphi study, the features investigated in the questionnaire and the experts invited to participate in the survey were issued from a bibliographic search. The questionnaire was iteratively proposed to experts via a web-based application with a feedback of the results observed at the preceding Delphi round. Experts were asked to label each investigated criterion in one of the following categories: absolutely required, important, of minor interest, or not assessable in the routine practice environment. A positive consensus was a priori defined as at least 75% answers observed in the categories absolutely required and important. The questionnaire investigated 26 criteria and 24 experts originating from 13 countries participated in the second and final Delphi round. A positive consensus was reached for the nine following criteria: unilineage cytopenia, bicytopenia, pancytopenia, presence of hemophagocytosis pictures on a bone marrow aspirate or on a tissue biopsy, high ferritin level, fever, organomegaly, presence of a predisposing underlying disease, and high level of lactate dehydrogenase. A negative consensus was reached for 13 criteria, and an absence of consensus was observed for 4 criteria. The study constitutes the first initiative to date for defining international guidelines devoted to the positive diagnosis of the reactive form of hemophagocytic syndrome.

  19. USING THE DELPHI TECHNIQUE TO DEVELOP EFFECTIVENESS INDICATORS FOR SOCIAL MARKETING COMMUNICATION TO REDUCE HEALTH-RISK BEHAVIORS AMONG YOUTH.

    PubMed

    Vantamay, Nottakrit

    2015-09-01

    This study aimed to develop effectiveness indicators for social marketing communication to reduce health-risk behaviors among Thai youth by using the Delphi technique. The Delphi technique is a research approach used to gain consensus through a series of two or more rounds of questionnaire surveys where information and results are fed back to panel members between each round and it has been extensively used to generate many indicators relevant to health behaviors. The Delphi technique was conducted in 3 rounds by consulting a panel of 15 experts in the field of social marketing communication for public health campaigns in Thailand. We found forty-nine effectiveness indicators in eight core components reached consensus. These components were: 1) attitude about health-risk behavior reduction, 2) subjective norms, 3) perceived behavioral control, 4) intention to reduce health-risk behaviors, 5) practices for reducing health-risk behaviors, 6) knowledge about the dangers and impact of health-risk behaviors, 7) campaign brand equity, and 8) communication networks. These effectiveness indicators could be applied by health promotion organizations for evaluating the effectiveness of social marketing communication to effectively reduce health-risk behaviors among youth.

  20. From ignorance to evidence? The use of programme evaluation in conservation: Evidence from a Delphi survey of conservation experts.

    PubMed

    Curzon, Hannah Fay; Kontoleon, Andreas

    2016-09-15

    Persistent gaps in the evidence base regarding the performance of conservation policies has put pressure on the conservation policy field to adopt 'best practice' programme evaluation methods. These are methods that account for the counterfactual and are able to attribute causality between a conservation policy and specific observable environmental and social impacts. Despite this pressure, use of such methods continues to be rare. This paper uses the Delphi technique to provide the first systematic assessment of the reasons behind the apparent hesitation of conservation practitioners to adopt rigorous policy impact evaluation methods. The Delphi study consisted of two online questionnaires conducted on conservation policy experts. The results presented confirm that the use of rigorous impact evaluation methods in conservation is still very limited but this, crucially, is not because conservationists are ignorant of these methods or their advantages. In fact, considerable effort is being made to develop and improve evidence standards but these efforts have largely been thwarted by large financial and time related constraints that mean even elementary evaluations are hard to achieve. The results from this Delphi study allow us to provide more realistic recommendations on how impact evaluation studies can be more widely embraced and implemented in conservation practice.

  1. Highly efficient and exact method for parallelization of grid-based algorithms and its implementation in DelPhi

    PubMed Central

    Li, Chuan; Li, Lin; Zhang, Jie; Alexov, Emil

    2012-01-01

    The Gauss-Seidel method is a standard iterative numerical method widely used to solve a system of equations and, in general, is more efficient comparing to other iterative methods, such as the Jacobi method. However, standard implementation of the Gauss-Seidel method restricts its utilization in parallel computing due to its requirement of using updated neighboring values (i.e., in current iteration) as soon as they are available. Here we report an efficient and exact (not requiring assumptions) method to parallelize iterations and to reduce the computational time as a linear/nearly linear function of the number of CPUs. In contrast to other existing solutions, our method does not require any assumptions and is equally applicable for solving linear and nonlinear equations. This approach is implemented in the DelPhi program, which is a finite difference Poisson-Boltzmann equation solver to model electrostatics in molecular biology. This development makes the iterative procedure on obtaining the electrostatic potential distribution in the parallelized DelPhi several folds faster than that in the serial code. Further we demonstrate the advantages of the new parallelized DelPhi by computing the electrostatic potential and the corresponding energies of large supramolecular structures. PMID:22674480

  2. USING THE DELPHI TECHNIQUE TO DEVELOP EFFECTIVENESS INDICATORS FOR SOCIAL MARKETING COMMUNICATION TO REDUCE HEALTH-RISK BEHAVIORS AMONG YOUTH.

    PubMed

    Vantamay, Nottakrit

    2015-09-01

    This study aimed to develop effectiveness indicators for social marketing communication to reduce health-risk behaviors among Thai youth by using the Delphi technique. The Delphi technique is a research approach used to gain consensus through a series of two or more rounds of questionnaire surveys where information and results are fed back to panel members between each round and it has been extensively used to generate many indicators relevant to health behaviors. The Delphi technique was conducted in 3 rounds by consulting a panel of 15 experts in the field of social marketing communication for public health campaigns in Thailand. We found forty-nine effectiveness indicators in eight core components reached consensus. These components were: 1) attitude about health-risk behavior reduction, 2) subjective norms, 3) perceived behavioral control, 4) intention to reduce health-risk behaviors, 5) practices for reducing health-risk behaviors, 6) knowledge about the dangers and impact of health-risk behaviors, 7) campaign brand equity, and 8) communication networks. These effectiveness indicators could be applied by health promotion organizations for evaluating the effectiveness of social marketing communication to effectively reduce health-risk behaviors among youth. PMID:26863866

  3. 26 CFR 36.3121(l)(3)-1 - Termination of agreement by domestic corporation or by reason of change in stock ownership.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... corporation or by reason of change in stock ownership. 36.3121(l)(3)-1 Section 36.3121(l)(3)-1 Internal... OF INCOME TAX AT SOURCE CONTRACT COVERAGE OF EMPLOYEES OF FOREIGN SUBSIDIARIES § 36.3121(l)(3)-1... domestic corporation. (1) A domestic corporation which has entered into an agreement under section...

  4. 26 CFR 36.3121(l)(3)-1 - Termination of agreement by domestic corporation or by reason of change in stock ownership.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... corporation or by reason of change in stock ownership. 36.3121(l)(3)-1 Section 36.3121(l)(3)-1 Internal... OF INCOME TAX AT SOURCE CONTRACT COVERAGE OF EMPLOYEES OF FOREIGN SUBSIDIARIES § 36.3121(l)(3)-1... domestic corporation. (1) A domestic corporation which has entered into an agreement under section...

  5. Economic instruments for obesity prevention: results of a scoping review and modified delphi survey

    PubMed Central

    2011-01-01

    Background Comprehensive, multi-level approaches are required to address obesity. One important target for intervention is the economic domain. The purpose of this study was to synthesize existing evidence regarding the impact of economic policies targeting obesity and its causal behaviours (diet, physical activity), and to make specific recommendations for the Canadian context. Methods Arksey and O'Malley's (2005) methodological framework for conducting scoping reviews was adopted for this study and this consisted of two phases: 1) a structured literature search and review, and 2) consultation with experts in the research field through a Delphi survey and an in-person expert panel meeting in April 2010. Results Two key findings from the scoping review included 1) consistent evidence that weight outcomes are responsive to food and beverage prices. The debate on the use of food taxes and subsidies to address obesity should now shift to how best to address practical issues in designing such policies; and 2) very few studies have examined the impact of economic instruments to promote physical activity and clear policy recommendations cannot be made at this time. Delphi survey findings emphasised the relatively modest impact any specific economic instrument would have on obesity independently. Based on empirical evidence and expert opinion, three recommendations were supported. First, to create and implement an effective health filter to review new and current agricultural polices to reduce the possibility that such policies have a deleterious impact on population rates of obesity. Second, to implement a caloric sweetened beverage tax. Third, to examine how to implement fruit and vegetable subsidies targeted at children and low income households. Conclusions In terms of economic interventions, shifting from empirical evidence to policy recommendation remains challenging. Overall, the evidence is not sufficiently strong to provide clear policy direction. Additionally

  6. Flood-inundation maps for the Tippecanoe River near Delphi, Indiana

    USGS Publications Warehouse

    Menke, Chad D.; Bunch, Aubrey R.; Kim, Moon H.

    2013-01-01

    Digital flood-inundation maps for an 11-mile reach of the Tippecanoe River that extends from County Road W725N to State Road 18 below Oakdale Dam, Indiana (Ind.), were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent of flooding corresponding to selected water levels (stages) at USGS streamgage 03333050, Tippecanoe River near Delphi, Ind. Current conditions at the USGS streamgages in Indiana may be obtained online at http://waterdata.usgs.gov/in/nwis/current/?type=flow. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often co-located at USGS streamgages. That forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, water-surface profiles were simulated for the stream reach by means of a hydraulic one-dimensional step-backwater model. The model was calibrated by using the most current stage-discharge relation at USGS streamgage 03333050, Tippecanoe River near Delphi, Ind., and USGS streamgage 03332605, Tippecanoe River below Oakdale Dam, Ind. The hydraulic model was then used to simulate 13 water-surface profiles for flood stages at 1-foot intervals reference to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the

  7. Development of disaster mental health guidelines through the Delphi process in Japan

    PubMed Central

    2012-01-01

    Background The mental health community in Japan had started reviewing the country’s disaster mental health guidelines before the Great East Japan Earthquake, aiming to revise them based on evidence and experience accumulated in the last decade. Given the wealth of experience and knowledge acquired in the field by many Japanese mental health professionals, we decided to develop the guidelines through systematic consensus building and selected the Delphi method. Methods After a thorough literature review and focus group interviews, 96 items regarding disaster mental health were included in Delphi Round 1. Of 100 mental health professionals experienced in disaster response who were invited to participate, 97 agreed. The appropriateness of each statement was assessed by the participants using a Likert scale (1: extremely inappropriate, 9: very appropriate) and providing free comments in three rounds. Consensus by experts was defined as an average score of ≥7 for which ≥70% of participants assigned this score, and items reaching consensus were included in the final guidelines. Results Overall, of the 96 items (89 initially asked and 7 added items), 77 items were agreed on (46 items in Round 1, and 19 positive and 12 negative agreed on items in Round 2). In Round 2, three statements with which participants agreed most strongly were: 1) A protocol for emergency work structure and information flow should be prepared in normal times; 2) The mental health team should attend regular meetings on health and medicine to exchange information; and 3) Generally, it is recommended not to ask disaster survivors about psychological problems at the initial response but ask about their present worries and physical condition. Three statements with which the participants disagreed most strongly in this round were: 1) Individuals should be encouraged to provide detailed accounts of their experiences; 2) Individuals should be provided with education if they are interested in receiving

  8. Complete genome sequence of the strain Defluviitoga tunisiensis L3, isolated from a thermophilic, production-scale biogas plant.

    PubMed

    Maus, Irena; Cibis, Katharina Gabriela; Wibberg, Daniel; Winkler, Anika; Stolze, Yvonne; König, Helmut; Pühler, Alfred; Schlüter, Andreas

    2015-06-10

    An anaerobic, thermophilic bacterium belonging to the phylum Thermotogae was isolated from a rural, thermophilic biogas plant (54°C) producing methane-rich biogas from maize silage, barley, cattle and pig manure. Here we report the first complete genome sequence of the Defluviitoga tunisiensis strain L3, an isolate from the family Thermotogaceae. The strain L3 encodes several genes predicted to be involved in utilization of a large diversity of complex carbohydrates including cellobiose and xylan for the production of acetate, hydrogen (H2) and carbon dioxide (CO2). The genome sequence of D. tunisiensis L3 provides the basis for biotechnological exploitation of genetic determinants playing an important role in thermophilic fermentation processes utilizing renewable primary products.

  9. Double photoexcitation involving 2p and 4f electrons in L3 -edge x-ray absorption spectra of protactinium

    NASA Astrophysics Data System (ADS)

    Hennig, Christoph; Le Naour, Claire; Auwer, Christophe Den

    2008-06-01

    The L3 -edge x-ray absorption spectrum of Pa(V) fluoride in aqueous solution show clear evidence for the double photoexcitation involving 2p and 4f electrons. A comparison with the [2p4f] double-electron excitations observed in the L3 -edge x-ray absorption spectra of other actinides (thorium, uranium, neptunium, plutonium, and americium) indicates a monotonic increase in the excitation energy. The sharp edgelike structure of the multielectron excitation reveals the origin of a shake-up channel.

  10. Nurses' expert opinions of workplace interventions for a healthy working environment: a Delphi survey.

    PubMed

    Doran, Diane; Clarke, Sean; Hayes, Laureen; Nincic, Vera

    2014-09-01

    Much has been written about interventions to improve the nursing work environment, yet little is known about their effectiveness. A Delphi survey of nurse experts was conducted to explore perceptions about workplace interventions in terms of feasibility and likelihood of positive impact on nurse outcomes such as job satisfaction and nurse retention. The interventions that received the highest ratings for likelihood of positive impact included: bedside handover to improve communication at shift report and promote patient-centred care; training program for nurses in dealing with violent or aggressive behaviour; development of charge nurse leadership team; training program focused on creating peer-supportive atmospheres and group cohesion; and schedule that recognizes work balance and family demands. The overall findings are consistent with the literature that highlights the importance of communication and teamwork, nurse health and safety, staffing and scheduling practices, professional development and leadership and mentorship. Nursing researchers and decision-makers should work in collaboration to implement and evaluate interventions for promoting practice environments characterized by effective communication and teamwork, professional growth and adequate support for the health and well-being of nurses. PMID:25676080

  11. DELPHI: A Pathfinder to LCAS on board the International Space Station

    NASA Astrophysics Data System (ADS)

    DeForest, C. E.; Howard, T. A.; Laurent, G. T.; Diller, J.

    2014-12-01

    NASA's venerable LCAS sounding rocket program has been the primary means to test new space instrumentation for space physics, for over 60 years. Recently, new LCAS pathways have been introduced for instruments and science that require longer exposure than a sounding rocket affords. The International Space Station (ISS) offers similar infrastructure to a sounding rocket, with ample mass and volume, controlled attitude, and predefined and generous power and telemetry interfaces. The DEmonstration LEO Polarizing Heliospheric Imager is an LCAS mission that pioneers replacing the SPARCS+black brant stack with the ISS itself, to exploit the environment afforded by the ISS and demonstrate new instrumentation on-orbit. DELPHI is a solar off-pointed heliospheric imager that demonstrates the use of pB/B and quantitative photometry to locate solar wind features in 3-D with high spatial resolution, in a few-month mission. It makes use of the stable environment and high telemetry volume (1Mbps) on ISS to improve image quality with ground postprocessing. It is built on the ISS-standard ExPA interface and robotically deployed from the Space-X Dragon trunk to an external mount location. We will discuss some of the engineering and programmatic trades go with designing an orbital sounding-rocket-class instrument, and advocate using ISS as a future platform for instrument development.

  12. Developing an industry-oriented safety curriculum using the Delphi technique.

    PubMed

    Chen, Der-Fa; Wu, Tsung-Chih; Chen, Chi-Hsiang; Chang, Shu-Hsuan; Yao, Kai-Chao; Liao, Chin-Wen

    2016-09-01

    In this study, we examined the development of industry-oriented safety degree curricula at a college level. Based on a review of literature on the practices and study of the development of safety curricula, we classified occupational safety and health curricula into the following three domains: safety engineering, health engineering, and safety and health management. We invited 44 safety professionals to complete a four-round survey that was designed using a modified Delphi technique. We used Chi-square statistics to test the panel experts' consensus on the significance of the items in the three domains and employed descriptive statistics to rank the participants' rating of each item. The results showed that the top three items for each of the three domains were Risk Assessment, Dangerous Machinery and Equipment, and Fire and Explosion Prevention for safety engineering; Ergonomics, Industrial Toxicology, and Health Risk Assessment for health engineering; and Industrial Safety and Health Regulations, Accident Investigation and Analysis, and Emergency Response for safety and health management. Only graduates from safety programmes who possess practical industry-oriented abilities can satisfy industry demands and provide value to the existence of college safety programmes.

  13. Prevention of adolescents' music-induced hearing loss due to discotheque attendance: a Delphi study.

    PubMed

    Vogel, I; Brug, J; Van der Ploeg, C P B; Raat, H

    2009-12-01

    Noise-induced hearing loss is a significant social and public health problem, which is found in increasing numbers of adolescents. Young people are particularly likely to expose themselves to potentially damaging loud sounds during leisure activities. Visiting discotheques is one of the most popular leisure activities of young people. Only a few minutes exposure to the sound levels played in discotheques can cause permanent hearing loss. Since little is known about what constitutes effective prevention strategies, we explored the opinions and ideas of 30 experts in a qualitative study consisting of a three-round web-based Delphi study. The main parties involved in the prevention of music-induced hearing loss due to discotheque attendance are as follows: the adolescents themselves, followed by the government, discotheque owners, decorators of discotheques and disk jockeys (DJs). None of the identified protective behaviors of adolescents was considered to be feasible. Five environmental interventions were identified as being both relevant and feasible; of these, the most important were that loudspeakers must be placed further away from the visitors and that discotheques have attractive, low-volume and clearly indicated 'chill-out rooms'. Effective prevention strategies to avoid music-induced hearing loss among adolescents due to discotheque attendance need to be taken primarily by discotheque owners and disk jockeys.

  14. Batteries for electric drive vehicles: Evaluation of future characteristics and costs through a Delphi study

    SciTech Connect

    Vyas, A.D.; Ng, H.K.; Anderson, J.L.; Santini, D.J.

    1997-07-01

    Uncertainty about future costs and operating attributes of electric drive vehicles (EVs and HEVs) has contributed to considerable debate regarding the market viability of such vehicles. One way to deal with such uncertainty, common to most emerging technologies, is to pool the judgments of experts in the field. Data from a two-stage Delphi study are used to project the future costs and operating characteristics of electric drive vehicles. The experts projected basic vehicle characteristics for EVs and HEVs for the period 2000-2020. They projected the mean EV range at 179 km in 2000, 270 km in 2010, and 358 km in 2020. The mean HEV range on battery power was projected as 145 km in 2000, 212 km in 2010, and 244 km in 2020. Experts` opinions on 10 battery technologies are analyzed and characteristics of initial battery packs for the mean power requirements are presented. A procedure to compute the cost of replacement battery packs is described, and the resulting replacement costs are presented. Projected vehicle purchase prices and fuel and maintenance costs are also presented. The vehicle purchase price and curb weight predictions would be difficult to achieve with the mean battery characteristics. With the battery replacement costs added to the fuel and maintenance costs, the conventional ICE vehicle is projected to have a clear advantage over electric drive vehicles through the projection period.

  15. DARE Train-the-Trainer Pedagogy Development Using 2-Round Delphi Methodology

    PubMed Central

    Kua, Phek Hui Jade; Soon, Swee Sung

    2016-01-01

    The Dispatcher-Assisted first REsponder programme aims to equip the public with skills to perform hands-only cardiopulmonary resuscitation (CPR) and to use an automated external defibrillator (AED). By familiarising them with instructions given by a medical dispatcher during an out-of-hospital cardiac arrest call, they will be prepared and empowered to react in an emergency. We aim to formalise curriculum and standardise the way information is conveyed to the participants. A panel of 20 experts were chosen. Using Delphi methodology, selected issues were classified into open-ended and close-ended questions. Consensus for an item was established at a 70% agreement rate within the panel. Questions that had 60%–69% agreement were edited and sent to the panel for another round of voting. After 2 rounds of voting, 70 consensus statements were agreed upon. These covered the following: focus of CPR; qualities and qualifications of trainers; recognition of agonal breathing; head-tilt-chin lift; landmark for chest compression; performance of CPR when injuries are present; trainers' involvement in training lay people; modesty of female patients during CPR; AED usage; content of trainer's manual; addressing of questions and answers; updates-dissemination to trainers and attendance of refresher courses. Recommendations for pedagogy for trainers of dispatcher-assisted CPR programmes were developed. PMID:27660757

  16. Designing a balanced scorecard for a tertiary care hospital in Pakistan: a modified Delphi group exercise.

    PubMed

    Rabbani, Fauziah; Jafri, Syed M Wasim; Abbas, Farhat; Shah, Mairaj; Azam, Syed Iqbal; Shaikh, Babar Tasneem; Brommels, Mats; Tomson, Goran

    2010-01-01

    Balanced Scorecards (BSC) are being implemented in high income health settings linking organizational strategies with performance data. At this private university hospital in Pakistan an elaborate information system exists. This study aimed to make best use of available data for better performance management. Applying the modified Delphi technique an expert panel of clinicians and hospital managers reduced a long list of indicators to a manageable size. Indicators from existing documents were evaluated for their importance, scientific soundness, appropriateness to hospital's strategic plan, feasibility and modifiability. Panel members individually rated each indicator on a scale of 1-9 for the above criteria. Median scores were assigned. Of an initial set of 50 indicators, 20 were finally selected to be assigned to the four BSC quadrants. These were financial (n = 4), customer or patient (n = 4), internal business or quality of care (n = 7) and innovation/learning or employee perspectives (n = 5). A need for stringent definitions, international benchmarking and standardized measurement methods was identified. BSC compels individual clinicians and managers to jointly work towards improving performance. This scorecard is now ready to be implemented by this hospital as a performance management tool for monitoring indicators, addressing measurement issues and enabling comparisons with hospitals in other settings.

  17. The Role Descriptions of Triage Nurse in Emergency Department: A Delphi Study

    PubMed Central

    Ebrahimi, Mohsen; Mazlom, Reza; Heydari, Abbas; Nassehi, Asra; Jafari, Mojtaba

    2016-01-01

    Background. Triage nurses play a pivotal role in the emergency department. However some researchers have attempted to expand triage nurse's role; remarkable discrepancies exist among scholarly communities. The aim was to develop a role description of triage nurse relying on the experts. Methods. A modified Delphi study consisting of 3 rounds was performed from March to October 2014. In the first round, an extensive review of the literature was conducted. Expert selection was conducted through a purposeful sample of 38 emergency medicine experts. Results. Response rates for the second and third rounds were 37% and 58%. Average age of panelists was (38.42 ± 5.94) years. Thirty-nine out of 54 items reached to the final round. Prioritizing had the higher agreement rate and least agreement on triage related interventions. Conclusion. Triage nursing as a relatively new role for nurses needs significant development to be practiced. Comprehensive educational programs and developmental research are required to support diagnostic and therapeutic interventions in triage practice by nurses. PMID:27382500

  18. Required competencies of occupational physicians: a Delphi survey of UK customers

    PubMed Central

    Reetoo, K; Harrington, J; Macdonald, E

    2005-01-01

    Background: Occupational physicians can contribute to good management in healthy enterprises. The requirement to take into account the needs of the customers when planning occupational health services is well established. Aims: To establish the priorities of UK employers, employees, and their representatives regarding the competencies they require from occupational physicians; to explore the reasons for variations of the priorities in different groups; and to make recommendations for occupational medicine training curricula in consideration of these findings. Methods: This study involved a Delphi survey of employers and employees from public and private organisations of varying business sizes, and health and safety specialists as well as trade union representatives throughout the UK. It was conducted in two rounds by a combination of computer assisted telephone interview (CATI) and postal survey techniques, using a questionnaire based on the list of competencies described by UK and European medical training bodies. Results: There was broad consensus about the required competencies of occupational physicians among the respondent subgroups. All the competencies in which occupational physicians are trained were considered important by the customers. In the order of decreasing importance, the competencies were: Law and Ethics, Occupational Hazards, Disability and Fitness for Work, Communication, Environmental Exposures, Research Methods, Health Promotion, and Management. Conclusion: The priorities of customers differed from previously published occupational physicians' priorities. Existing training programmes for occupational physicians should be regularly reviewed and where necessary, modified to ensure that the emphasis of training meets customer requirements. PMID:15901889

  19. Innovations and trends in meat consumption: an application of the Delphi method in Spain.

    PubMed

    Chamorro, Antonio; Miranda, Francisco J; Rubio, Sergio; Valero, Víctor

    2012-12-01

    The meat sector in Spain is an important industry. However, traditional consumption is changing as a result of the country's economic crisis and the new structure of households. The objective of the present study was to identify trends in meat consumption in Spain extrapolated to 2016, and the main innovations that should be of interest to firms in the sector. The study was conducted in 2011 using the Delphi method with the participation of 26 experts. The results showed that, while the demand for meat will not vary significantly in amount, it will do so in composition, with chicken replacing beef as the meat of most importance in the shopping basket. In addition, significant growth is expected in certified meat, but the demand for organic meat will not take off. Neither will there be no significant changes in end purchase formats, but there will be a clear trend in consumers' purchasing decision criteria away from price, external appearance and origin towards quality certification and the attributes of the packaging. With respect to end purchase channels, the experts estimate that the current trend will be accentuated with increasing market share for large supermarkets and major distribution brands.

  20. Quality issues concerning genetic counselling for presymptomatic testing: a European Delphi study.

    PubMed

    Paneque, Milena; Sequeiros, Jorge; Skirton, Heather

    2015-11-01

    Genetic counselling for presymptomatic testing is complex, bringing both ethical and practical questions. There are protocols for counselling but a scarcity of literature regarding quality assessment of such counselling practice. Generic quality assessment tools for genetic services are not specific to presymptomatic testing (PST). Therefore, the aim of this study was to identify aspects of effective counselling practice in PST for late-onset neurological disorders. We used the Delphi method to ascertain the views of relevant European experts in genetic counselling practice, ascertained via published literature and nomination by practitioners. Ethical approval was obtained. Questionnaires were sent electronically to a list of 45 experts, (Medical Doctors, Geneticists, Genetic Counsellors and Genetic Nurses), who each contributed to one to three rounds. In the first round, we provided a list of relevant indicators of quality of practice from a literature review. Experts were requested to evaluate topics in four domains: (a) professional standards; (b) service standards; (c) the consultant's perspective; and (d) protocol standards. We then removed items receiving less than 65% approval and added new issues suggested by experts. The second round was performed for the refinement of issues and the last round was aimed at achieving final consensus on high-standard indicators of quality, for inclusion in the assessment tool. The most relevant indicators were related to (1) consultant-centred practice and (2) advanced counselling and interpersonal skills of professionals. Defined high-standard indicators can be used for the development of a new tool for quality assessment of PST counselling practice.

  1. Future directions for research in laboratory medicine: the findings of a Delphi survey of stakeholders.

    PubMed

    Maibach, H; Keenlyside, R; Fitzmaurice, D; Brogan, D; Essien, J

    1998-01-01

    In July 1995, we asked 101 experts to anticipate future areas for research in clinical laboratory medicine using a modified Delphi survey approach. The panel included academicians, clinical laboratory professionals, laboratory managers, practicing physicians public health officials, hospital administrators, and representatives of manufacturing industries, managed care organizations, commercial laboratories, and government health agencies. The participants predicted fewer laboratories, more automation, and fewer skilled staff needed in the future. The consensus was that laboratory quality assurance will focus on patient outcomes and be benchmarked against peer groups. They agreed that quality assurance routinely will be integrated into testing kits. Measures derived from medical informatics, such as outcomes analysis and utilization statistics, will become a standard feature of health care. A major area of concern was the effect that reorganizing health care and striving for cost containment will have on laboratory services. These views were consistent with those expressed by participants at a CDC conference on the frontiers of laboratory medicine research held shortly after the study was completed. These topics by now are familiar to most laboratory professionals, and we urge them to explore the many research issues raised with their colleagues in their clinical laboratories, health-care organizations, and industry.

  2. Innovations and trends in meat consumption: an application of the Delphi method in Spain.

    PubMed

    Chamorro, Antonio; Miranda, Francisco J; Rubio, Sergio; Valero, Víctor

    2012-12-01

    The meat sector in Spain is an important industry. However, traditional consumption is changing as a result of the country's economic crisis and the new structure of households. The objective of the present study was to identify trends in meat consumption in Spain extrapolated to 2016, and the main innovations that should be of interest to firms in the sector. The study was conducted in 2011 using the Delphi method with the participation of 26 experts. The results showed that, while the demand for meat will not vary significantly in amount, it will do so in composition, with chicken replacing beef as the meat of most importance in the shopping basket. In addition, significant growth is expected in certified meat, but the demand for organic meat will not take off. Neither will there be no significant changes in end purchase formats, but there will be a clear trend in consumers' purchasing decision criteria away from price, external appearance and origin towards quality certification and the attributes of the packaging. With respect to end purchase channels, the experts estimate that the current trend will be accentuated with increasing market share for large supermarkets and major distribution brands. PMID:22878051

  3. Common dolphin ( Delphinus delphis) habitat preferences using data from two platforms of opportunity

    NASA Astrophysics Data System (ADS)

    Moura, André E.; Sillero, Neftalí; Rodrigues, Ana

    2012-01-01

    Cetaceans are difficult to observe in the wild, and demand complex logistics for dedicated collection of biological data. As such, the distribution of most cetacean species is still poorly understood. Ecological niche models are useful in studying species distributions and their ecological determinants, and platforms of opportunity (e.g. commercial nautical operators) can provide an alternative source for that data in cetaceans. In this study, we modelled common dolphin ( Delphinus delphis) habitat preferences using ecological niche modelling and presence data obtained from distinct platforms of opportunity in two different areas in the Portuguese coast (west and south mainland Portugal) for the period 2005-2007. Models from southern Portugal were projected to western Portugal and vice-versa, to check for robustness in predicting the species ecological niche. Our results show that data from platforms of opportunity can result in robust ecological models and provide extremely useful information on cetacean ecology. We found that common dolphins exhibit a patchy distribution pattern over the Portuguese coastline, and identified key habitats for their occurrence. The most important variable associated with this species' distribution was chlorophyll concentration which, given the results from previous research, we hypothesise reflects an ecological specialisation on pelagic schooling fish. Given that the most abundant schooling fish species in Portugal is increasingly overexploited and in constant decline, more attention should be given to the conservation of common dolphin in Portuguese waters.

  4. Target outcomes for long-term oral health care in dementia: a Delphi approach.

    PubMed

    Jones, J A; Brown, E J; Volicer, L

    2000-01-01

    This study developed a list of target outcomes for long-term oral health care in persons with dementia. A three-round Delphi study was used to develop a list of target outcomes. Participants included 99 staff and 171 family members associated with the Dementia Special Care Unit in Bedford, MA. In Round 1 participants were asked to list five outcomes for long-term oral health care. Items were grouped, redundancies removed, and fed back in Round 2, when participants scored the items from 1 (least important) to 10 (most important). Round 2 responses were tabulated and the top 20 were fed back for scoring in Round 3. The top 10 target outcomes in decreasing order of importance were: patient will be free from oral pain, patient will not be at risk for aspiration, emergency dental treatment will be available when needed, prevent mouth infections, daily mouth care is as much a part of daily care as shaving or brushing hair, prevent discomfort from loose teeth or sore gums, teeth will be brushed thoroughly once a day, staff will be able to provide oral hygiene care as needed, provide dental care to prevent problems eating, and recognize oral problems early. Family and professional caregivers were remarkably consistent in their identification of the top 10 outcomes. Further work is needed to ensure broad international and interdisciplinary acceptance (including families and the long-term care residents themselves) of target outcomes for long-term oral health care in persons with dementia. PMID:11243056

  5. Target outcomes for long-term oral health care in dementia: a Delphi approach.

    PubMed

    Jones, J A; Brown, E J; Volicer, L

    2000-01-01

    This study developed a list of target outcomes for long-term oral health care in persons with dementia. A three-round Delphi study was used to develop a list of target outcomes. Participants included 99 staff and 171 family members associated with the Dementia Special Care Unit in Bedford, MA. In Round 1 participants were asked to list five outcomes for long-term oral health care. Items were grouped, redundancies removed, and fed back in Round 2, when participants scored the items from 1 (least important) to 10 (most important). Round 2 responses were tabulated and the top 20 were fed back for scoring in Round 3. The top 10 target outcomes in decreasing order of importance were: patient will be free from oral pain, patient will not be at risk for aspiration, emergency dental treatment will be available when needed, prevent mouth infections, daily mouth care is as much a part of daily care as shaving or brushing hair, prevent discomfort from loose teeth or sore gums, teeth will be brushed thoroughly once a day, staff will be able to provide oral hygiene care as needed, provide dental care to prevent problems eating, and recognize oral problems early. Family and professional caregivers were remarkably consistent in their identification of the top 10 outcomes. Further work is needed to ensure broad international and interdisciplinary acceptance (including families and the long-term care residents themselves) of target outcomes for long-term oral health care in persons with dementia.

  6. Barriers to clinical adoption of next generation sequencing: Perspectives of a policy Delphi panel.

    PubMed

    Messner, Donna A; Al Naber, Jennifer; Koay, Pei; Cook-Deegan, Robert; Majumder, Mary; Javitt, Gail; Deverka, Patricia; Dvoskin, Rachel; Bollinger, Juli; Curnutte, Margaret; Chandrasekharan, Subhashini; McGuire, Amy

    2016-09-01

    This research aims to inform policymakers by engaging expert stakeholders to identify, prioritize, and deliberate the most important and tractable policy barriers to the clinical adoption of next generation sequencing (NGS). A 4-round Delphi policy study was done with a multi-stakeholder panel of 48 experts. The first 2 rounds of online questionnaires (reported here) assessed the importance and tractability of 28 potential barriers to clinical adoption of NGS across 3 major policy domains: intellectual property, coverage and reimbursement, and FDA regulation. We found that: 1) proprietary variant databases are seen as a key challenge, and a potentially intractable one; 2) payer policies were seen as a frequent barrier, especially a perceived inconsistency in standards for coverage; 3) relative to other challenges considered, FDA regulation was not strongly perceived as a barrier to clinical use of NGS. Overall the results indicate a perceived need for policies to promote data-sharing, and a desire for consistent payer coverage policies that maintain reasonably high standards of evidence for clinical utility, limit testing to that needed for clinical care decisions, and yet also flexibly allow for clinician discretion to use genomic testing in uncertain circumstances of high medical need. PMID:27668172

  7. Environmental and occupational health research and training needs in Colombia: A Delphi study

    PubMed Central

    Rodríguez-Villamizar, Laura A.; González, Beatriz Elena; Vera, Lina María; Patz, Jonathan; Bautista, Leonelo E.

    2015-01-01

    Introduction Environmental factors contribute with 16% of the burden of disease in Colombia. A main obstacle in implementing national and regional environmental and occupational health policies is the limited knowledge on the local ability to study and control the impact of harmful exposures on health. Objective To identify needs for research and training in environmental and occupational health in Colombia. Materials and methods We conducted a three-round hybrid Delphi study. A group of environmental and occupational health Colombian experts (n=16) from government agencies, universities, and research centers was recruited to participate in the study. Expert’s opinions on research and training needs were gathered through online questionnaires, followed by an in-person meeting. The percentage of agreement and the coefficient of variation were used to measure consensus. Results Air pollution and chemical products were considered the most important environmental and occupational exposures, due to their significant impact on chronic non-communicable diseases, such as respiratory diseases, cardiovascular diseases, and cancer. Research on the effects of outdoor air pollution on cardiovascular and respiratory diseases was considered of the greatest importance. Priority training areas included environmental and occupational health risk assessment, exposure modeling, advanced statistical methods, urban planning, occupational safety and hygiene, and epidemiology and toxicology. Conclusions These findings provide a valuable input for the definition and implementation of national environmental and occupational health policies and for the development of a regional hub aimed at strengthening the capacity for research and training in Colombia. PMID:26535742

  8. Prescribing for Australians living with dementia: study protocol using the Delphi technique

    PubMed Central

    Page, Amy; Potter, Kathleen; Clifford, Rhonda; McLachlan, Andrew; Etherton-Beer, Christopher

    2015-01-01

    Introduction Prescribing is complicated for people living with dementia, and careful consideration should be given to continuing and initiating all medicines. This study aims to elicit opinion and gain consensus on appropriate medicine use for people living with dementia in Australia to create a consensus-based list of explicit prescribing criteria. Methods and analysis A Delphi technique will be used to develop explicit criteria of medication use in adults aged 65 years and above. An interdisciplinary panel of Australian experts in geriatric therapeutics will be convened that will consist of a minimum of 10 participants. To develop the consensus-based criteria, this study will use an iterative, anonymous, multistaged approach with controlled feedback. Round 1 questionnaire will be administered, and subsequently qualitatively analysed. The round 1 results will be fed back to the panel members, and a round 2 questionnaire developed using questions on a five-point Likert scale. This process will repeat until consensus is developed, or diminishing returns are noted. Ethics and dissemination All participants will be provided with a participant information sheet, and sign a written consent form. Ethical approval has been granted from the University of Western Australia's Human Research Ethics Committee (HREC) (reference: RA/4/1/7172). We expect that data from this study will result in a paper published in a peer-reviewed clinical journal and will also present the results at conferences. PMID:26264272

  9. Nurses' expert opinions of workplace interventions for a healthy working environment: a Delphi survey.

    PubMed

    Doran, Diane; Clarke, Sean; Hayes, Laureen; Nincic, Vera

    2014-09-01

    Much has been written about interventions to improve the nursing work environment, yet little is known about their effectiveness. A Delphi survey of nurse experts was conducted to explore perceptions about workplace interventions in terms of feasibility and likelihood of positive impact on nurse outcomes such as job satisfaction and nurse retention. The interventions that received the highest ratings for likelihood of positive impact included: bedside handover to improve communication at shift report and promote patient-centred care; training program for nurses in dealing with violent or aggressive behaviour; development of charge nurse leadership team; training program focused on creating peer-supportive atmospheres and group cohesion; and schedule that recognizes work balance and family demands. The overall findings are consistent with the literature that highlights the importance of communication and teamwork, nurse health and safety, staffing and scheduling practices, professional development and leadership and mentorship. Nursing researchers and decision-makers should work in collaboration to implement and evaluate interventions for promoting practice environments characterized by effective communication and teamwork, professional growth and adequate support for the health and well-being of nurses.

  10. DARE Train-the-Trainer Pedagogy Development Using 2-Round Delphi Methodology

    PubMed Central

    Kua, Phek Hui Jade; Soon, Swee Sung

    2016-01-01

    The Dispatcher-Assisted first REsponder programme aims to equip the public with skills to perform hands-only cardiopulmonary resuscitation (CPR) and to use an automated external defibrillator (AED). By familiarising them with instructions given by a medical dispatcher during an out-of-hospital cardiac arrest call, they will be prepared and empowered to react in an emergency. We aim to formalise curriculum and standardise the way information is conveyed to the participants. A panel of 20 experts were chosen. Using Delphi methodology, selected issues were classified into open-ended and close-ended questions. Consensus for an item was established at a 70% agreement rate within the panel. Questions that had 60%–69% agreement were edited and sent to the panel for another round of voting. After 2 rounds of voting, 70 consensus statements were agreed upon. These covered the following: focus of CPR; qualities and qualifications of trainers; recognition of agonal breathing; head-tilt-chin lift; landmark for chest compression; performance of CPR when injuries are present; trainers' involvement in training lay people; modesty of female patients during CPR; AED usage; content of trainer's manual; addressing of questions and answers; updates-dissemination to trainers and attendance of refresher courses. Recommendations for pedagogy for trainers of dispatcher-assisted CPR programmes were developed.

  11. Designing a balanced scorecard for a tertiary care hospital in Pakistan: a modified Delphi group exercise.

    PubMed

    Rabbani, Fauziah; Jafri, Syed M Wasim; Abbas, Farhat; Shah, Mairaj; Azam, Syed Iqbal; Shaikh, Babar Tasneem; Brommels, Mats; Tomson, Goran

    2010-01-01

    Balanced Scorecards (BSC) are being implemented in high income health settings linking organizational strategies with performance data. At this private university hospital in Pakistan an elaborate information system exists. This study aimed to make best use of available data for better performance management. Applying the modified Delphi technique an expert panel of clinicians and hospital managers reduced a long list of indicators to a manageable size. Indicators from existing documents were evaluated for their importance, scientific soundness, appropriateness to hospital's strategic plan, feasibility and modifiability. Panel members individually rated each indicator on a scale of 1-9 for the above criteria. Median scores were assigned. Of an initial set of 50 indicators, 20 were finally selected to be assigned to the four BSC quadrants. These were financial (n = 4), customer or patient (n = 4), internal business or quality of care (n = 7) and innovation/learning or employee perspectives (n = 5). A need for stringent definitions, international benchmarking and standardized measurement methods was identified. BSC compels individual clinicians and managers to jointly work towards improving performance. This scorecard is now ready to be implemented by this hospital as a performance management tool for monitoring indicators, addressing measurement issues and enabling comparisons with hospitals in other settings. PMID:20191594

  12. A decision-making framework for total ownership cost management of complex systems: A Delphi study

    NASA Astrophysics Data System (ADS)

    King, Russel J.

    This qualitative study, using a modified Delphi method, was conducted to develop a decision-making framework for the total ownership cost management of complex systems in the aerospace industry. The primary focus of total ownership cost is to look beyond the purchase price when evaluating complex system life cycle alternatives. A thorough literature review and the opinions of a group of qualified experts resulted in a compilation of total ownership cost best practices, cost drivers, key performance factors, applicable assessment methods, practitioner credentials and potential barriers to effective implementation. The expert panel provided responses to the study questions using a 5-point Likert-type scale. Data were analyzed and provided to the panel members for review and discussion with the intent to achieve group consensus. As a result of the study, the experts agreed that a total ownership cost analysis should (a) be as simple as possible using historical data; (b) establish cost targets, metrics, and penalties early in the program; (c) monitor the targets throughout the product lifecycle and revise them as applicable historical data becomes available; and (d) directly link total ownership cost elements with other success factors during program development. The resultant study framework provides the business leader with incentives and methods to develop and implement strategies for controlling and reducing total ownership cost over the entire product life cycle when balancing cost, schedule, and performance decisions.

  13. Clarifying concepts of food parenting practices. A Delphi study with an application to snacking behavior.

    PubMed

    Gevers, D W M; Kremers, S P J; de Vries, N K; van Assema, P

    2014-08-01

    Inconsistencies in measurements of food parenting practices continue to exist. Fundamental to this problem is the lack of clarity about what is understood by different concepts of food parenting practices. The purpose of this study was to clarify food parenting practice concepts related to snacking. A three round Delphi study among an international group of experts (n = 63) was conducted. In the first round, an open-ended survey was used to collect food parenting practice descriptions and concept labels associated with those practices. In the second round, participants were asked to match up descriptions with the appropriate concept labels. The third and final round allowed participants to reconsider how descriptions and concept labels were matched, taking into account the opinions expressed in round two. Round one produced 408 descriptions of food parenting practices and 110 different concept names. Round two started with 116 descriptions of food parenting practices and 20 concept names. On 40 descriptions, consensus regarding the underlying concept name was reached in round two. Of the remaining 76 descriptions, consensus on 47 descriptions regarding the underlying concept name was reached in round three. The present study supports the essential process of consensus development with respect to food parenting practices concepts. PMID:24732407

  14. Microwave window breakdown experiments and simulations on the UM/L-3 relativistic magnetron.

    PubMed

    Hoff, B W; Mardahl, P J; Gilgenbach, R M; Haworth, M D; French, D M; Lau, Y Y; Franzi, M

    2009-09-01

    Experiments have been performed on the UM/L-3 (6-vane, L-band) relativistic magnetron to test a new microwave window configuration designed to limit vacuum side breakdown. In the baseline case, acrylic microwave windows were mounted between three of the waveguide coupling cavities in the anode block vacuum housing and the output waveguides. Each of the six 3 cm deep coupling cavities is separated from its corresponding anode cavity by a 1.75 cm wide aperture. In the baseline case, vacuum side window breakdown was observed to initiate at single waveguide output powers close to 20 MW. In the new window configuration, three Air Force Research Laboratory-designed, vacuum-rated directional coupler waveguide segments were mounted between the coupling cavities and the microwave windows. The inclusion of the vacuum side power couplers moved the microwave windows an additional 30 cm away from the anode apertures. Additionally, the Lucite microwave windows were replaced with polycarbonate windows and the microwave window mounts were redesigned to better maintain waveguide continuity in the region around the microwave windows. No vacuum side window breakdown was observed in the new window configuration at single waveguide output powers of 120+MW (a factor of 3 increase in measured microwave pulse duration and factor of 3 increase in measured peak power over the baseline case). Simulations were performed to investigate likely causes for the window breakdown in the original configuration. Results from these simulations have shown that in the original configuration, at typical operating voltage and magnetic field ranges, electrons emitted from the anode block microwave apertures strike the windows with a mean kinetic energy of 33 keV with a standard deviation of 14 keV. Calculations performed using electron impact angle and energy data predict a first generation secondary electron yield of 65% of the primary electron population. The effects of the primary aperture electron

  15. Whole-body kinetics and dosimetry of L-3--123I-iodo-alpha-methyltyrosine.

    PubMed

    Schmidt, D; Langen, K J; Herzog, H; Wirths, J; Holschbach, M; Kiwit, J C; Ziemons, K; Coenen, H H; Müller-Gärtner, H

    1997-09-01

    The synthetic amino acid L-3--123I-iodo-alpha-methyltyrosine (IMT) is currently under clinical evaluation as a single-photon emission tomography (SPET) tracer of amino acid uptake in brain tumours. So far, dosimetric data in respect of IMT are not available. Therefore we investigated the whole-body distribution of IMT in six patients with cerebral gliomas and the radiation doses were estimated. Whole-body scans were acquired at 1.5, 3 and 5 h after i.v. injection of 370-550 MBq IMT. The bladder was voided prior to each scan and the radioactivity excreted in the urine was measured. Based on the MIRD-11 method and the updated MIRDOSE3, the mean absorbed doses for various organs and the effective dose were calculated from geometric means of the anterior and posterior whole-body scans using seven source organs and the residence time. IMT was predominantly excreted by the kidneys (52.8%+/-11.5% at 1.5 h p.i., 63.0%+/-15.7% at 3 h p.i. and 74.6%+/-9.8% at 5 h p.i.). No organ system other than the urinary tract showed significant retention of the tracer. Early whole-body scans revealed slightly increased tracer uptake in the liver and in the bowel. Highest absorbed doses were found for the urinary bladder wall (0.047 mGy/MBq), the kidneys (0.010 mGy/MBq), the lower large intestinal wall (0.011 mGy/MBq) and the upper large intestinal wall (0.008 mGy/MBq). The effective dose according to ICRP 60 was estimated to be 0.0073 mSv/MBq for adults. This leads to an effective dose of 3.65 mSv in a typical brain SPET study using 500 MBq IMT. The MIRDOSE3 scheme yielded similar results. Thus, in spite of the relatively high tracer dose required for optimal brain scanning, radiation exposure in SPET studies with IMT is in the normal range of routine nuclear medicine investigations. PMID:9283111

  16. LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells.

    PubMed

    Zanelatto, Leonardo Campos; Silva, Patrícia Benites Gonçalves da; Sartori, Daniele; Panis, Carolina; Lepri, Sandra; Fátima, Ângelo de; Mantovani, Mário Sérgio

    2016-01-01

    The identification of antitumoral substances is the focus of intense biomedical research. Two structural analogues of thalidomide, LNO3 and L3, are two synthetic compounds that might possess such antitumor properties. We evaluated the toxicological effects of these substances, including cytotoxicity, genotoxicity and induction of apoptosis in HTC cells. Additionally, the production of free radicals (nitric oxide and superoxide) was investigated, and the expression of caspases genes 3, 8, and 9 were determined by RT-qPCR. The compounds exhibited cytotoxic effects that resulted in inhibited cell proliferation. LNO3 showed to be more effective and toxic than L3 in all assays. LNO3 stimulated the release of NO and superoxide, which was accompanied by the formation of peroxynitrite. Apoptosis was induced in a dose-dependent manner by both compounds; however, the expression of caspases 3, 8 and 9 was unchanged. These results suggested that L3 and LNO3 possess antiproliferative and pro-apoptotic effects in HTC cells. Additionally, although they exhibited cytotoxicity, L3 and LNO3 might be useful coadjuvants in tumor treatment studies. PMID:27303908

  17. LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells

    PubMed Central

    Zanelatto, Leonardo Campos; da Silva, Patrícia Benites Gonçalves; Sartori, Daniele; Panis, Carolina; Lepri, Sandra; de Fátima, Ângelo; Mantovani, Mário Sérgio

    2016-01-01

    Abstract The identification of antitumoral substances is the focus of intense biomedical research. Two structural analogues of thalidomide, LNO3 and L3, are two synthetic compounds that might possess such antitumor properties. We evaluated the toxicological effects of these substances, including cytotoxicity, genotoxicity and induction of apoptosis in HTC cells. Additionally, the production of free radicals (nitric oxide and superoxide) was investigated, and the expression of caspases genes 3, 8, and 9 were determined by RT-qPCR. The compounds exhibited cytotoxic effects that resulted in inhibited cell proliferation. LNO3 showed to be more effective and toxic than L3 in all assays. LNO3 stimulated the release of NO and superoxide, which was accompanied by the formation of peroxynitrite. Apoptosis was induced in a dose-dependent manner by both compounds; however, the expression of caspases 3, 8 and 9 was unchanged. These results suggested that L3 and LNO3 possess antiproliferative and pro-apoptotic effects in HTC cells. Additionally, although they exhibited cytotoxicity, L3 and LNO3 might be useful coadjuvants in tumor treatment studies. PMID:27303908

  18. The Multilingual Reader: Advantages in Understanding and Decoding German Sentence Structure when Reading German as an L3

    ERIC Educational Resources Information Center

    Peyer, Elisabeth; Kaiser, Irmtraud; Berthele, Raphael

    2010-01-01

    This study investigates Italian and French students' grammatical problems while reading in German as an L3 or L4. For the study, we developed a reading test which consists of invented encyclopaedia articles on imaginary animals. These articles enabled us to test various grammatical structures for their receptive difficulty. This paper discusses…

  19. A single amino acid in the helicase domain of PMMoV-S is responsible for its enhanced accumulation in C. chinense (L(3)L(3)) plants at 32°C.

    PubMed

    Tena, Fátima; Molina-Galdeano, Myriam; Serra, Maria Teresa; García-Luque, Isabel

    2012-05-25

    In Capsicum chinense (L(3)L(3)) plants a higher accumulation of the tobamovirus Pepper mild mottle virus strain S (PMMoV-S) as compared to the Italian strain PMMoV-I is detected when plants are grown at 32°C. By using a reverse genetic approach, we have established that a single amino acid at position 898 in the helicase domain of the polymerase protein, outside of the conserved regions of the helicase, is critical for the higher accumulation of PMMoV-S observed. It also is necessary for both increased accumulation of viral RNA of both polarities in pepper protoplasts and enhanced cell-to-cell movement in C. chinense plants. The influence of thermoresistance of PMMoV-S, a P(1,2) pathotype, and its prevalence on pepper cultivars over PMMoV-I, a P(1,2,3), pathotype, is discussed.

  20. Cyclosporine A prevents the generation of single positive (Lyt2+ L3T4-, Lyt2- L3T4+) mature T cells, but not single positive (Lyt2+ T3-) Immature thymocytes, in newborn mice.

    PubMed

    Heeg, K; Bendigs, S; Wagner, H

    1989-12-01

    The influence of cyclosporine A (CsA) on T-cell maturation was investigated in newborn mice. CsA treatment during the pre- and postnatal periods resulted in a hypoplasia of peripheral lymphatic organs, and absence of mature T3+ T cells in lymph nodes and spleens; no functional T-cell reactivity was observed. In thymuses of CsA-treated mice, no T3+ single positive Lyt2+ or T3+L3T4+ thymocytes could be found, but double positive (DP) cells were readily detected. A thymocyte subset with the phenotype Lyt2+L3T4-T3- was still discernible; this population was non-functional in vitro. The data show that the maturation of single positive (SP) T cells is critically influenced by CsA; under the conditions used here we found no evidence that 'leaky' autoreactive SP T cells develop in CsA-treated newborn mice.

  1. Management of problematic behaviours among individuals on long-term opioid therapy: protocol for a Delphi study

    PubMed Central

    Merlin, Jessica S; Young, Sarah R; Azari, Soraya; Becker, William C; Liebschutz, Jane M; Pomeranz, Jamie; Roy, Payel; Saini, Shalini; Starrels, Joanna L; Edelman, E Jennifer

    2016-01-01

    Introduction Given the sharp rise in opioid prescribing and heightened recognition of opioid addiction and overdose, opioid safety has become a priority. Clinical guidelines on long-term opioid therapy (LTOT) for chronic pain consistently recommend routine monitoring and screening for problematic behaviours. Yet, there is no consensus definition regarding what constitutes a problematic behaviour, and recommendations for appropriate management to inform front-line providers, researchers and policymakers are lacking. This creates a barrier to effective guideline implementation. Thus, our objective is to present the protocol for a Delphi study designed to: (1) elicit expert opinion to identify the most important problematic behaviours seen in clinical practice and (2) develop consensus on how these behaviours should be managed in the context of routine clinical care. Methods/analysis We will include clinical experts, defined as individuals who provide direct patient care to adults with chronic pain who are on LTOT in an ambulatory setting, and for whom opioid prescribing for chronic non-malignant pain is an area of expertise. The Delphi study will be conducted online in 4 consecutive rounds. Participants will be asked to list problematic behaviours and identify which behaviours are most common and challenging. They will then describe how they would manage the most frequently occurring common and challenging behaviours, rating the importance of each management strategy. Qualitative analysis will be used to categorise behaviours and management strategies, and consensus will be based on a definition established a priori. Ethics/dissemination This study has been approved by the Institutional Review Board (IRB) of the University of Alabama at Birmingham (UAB). This study will generate Delphi-based expert consensus on the management of problematic behaviours that arise in individuals on LTOT, which we will publish and disseminate to appropriate professional societies

  2. Stratigraphy, structure, and zonation of large Silurian reef at Delphi, Indiana

    SciTech Connect

    Archer, A.W.; Bottjer, D.J.; Droste, J.B.; Horowitz, A.S.; Kelly, S.M.; Krisher, D.L.; Shaver, R.H.

    1980-01-01

    A Silurian reef complex at Delphi, Indiana, consists of two subcircular reefs occupying an area of about 4 sq mi (10.6 sq km). The reef is more than 400 ft (62 m) thick, has a volume of about 0.15 cu mi (0.64 cu km), and effected as much as 75 ft (23 m) of compaction-induced drape in the overlying Middle Devonian strata. Stratigraphically, the complex extends upward from Salamonie (Middle Silurian) into Salina rocks (Upper Silurian). Growth of the complex proceeded through alternating periods of lateral expansion and restriction as reflected in the cross-sectional geometry of at least one of the reefs. These growth characteristics probably reflect the conditions that led to cyclic deposition of carbonate and evaporite rocks in the Michigan basin during Middle to Late Silurian time. Present dips along reef flanks locally exceed 35/sup 0/ but structural and stratigraphic analyses suggest that original depositional slopes may have been more gentle, that reef tops were never appreciably more than 200 ft (60 m) above the seafloor (although reef thicknesses of several hundred feet were attained before erosion), and that the central parts of the main reef masses were occupied by relatively rigid and volumetrically litle changing structural cores. Biozones include: two central areas of highest organic-framework buildup characterized by corals and stromatoporoids and flanking zones characterized separately by echinodermal and other debris, pentamerid brachiopods, gastropods, and fine debris and chert. The zonal distribution is similar to that already proposed for the large Silurian reef at Monon, Indiana, and somewhat resembles that proposed for the reef at Thornton, Illinois. These similarities and the fact of zonation in itself help to support the conclusion that the often debated Silurian buildups in the Great Lakes area satisfy all but the most rigid definitions of ecologic (organic-framework) reefs. 8 figures, 1 table.

  3. Identification of performance indicators for emergency centres in South Africa: results of a Delphi study

    PubMed Central

    Hodkinson, Peter; Wallis, Lee

    2010-01-01

    Background Emergency medicine is a rapidly developing field in South Africa (SA) and other developing nations. There is a need to develop performance indicators that are relevant and easy to measure. This will allow identification of areas for improvement, create standards of care and allow inter-institutional comparisons to be made. There is evidence from the international literature that performance measures do lead to performance improvements. Aims To develop a broad-based consensus document detailing quality measures for use in SA Emergency Centres (ECs). Methods A three-round modified Delphi study was conducted over e-mail. A panel of experts representing the emergency medicine field in SA was formed. Participants were asked to provide potential performance indicators for use in SA, under subheaders of the various disciplines that are seen in emergency patients. These statements were collated and sent out to the panel for scoring on a 9-point Lickert scale. Statements that did not reach a predefined consensus were sent back to the panellist for reconsideration. Results Consensus was reached on 99 out of 153 (65%) of the performance indicators proposed. These were further refined, and a synopsis of the statements is presented, classified as to whether the statements were thought to be feasible or not in the current circumstances. Conclusions A synopsis of the useful and feasible performance indicators is presented. The majority are structural and performance-based indicators appropriate to the development of the field in SA. Further refinement and research is needed to implement these indicators. Electronic supplementary material The online version of this article (doi:10.1007/s12245-010-0240-6) contains supplementary material, which is available to authorized users. PMID:21373303

  4. What clinical activities do advanced-practice registered dietitian nutritionists perform? Results of a Delphi study.

    PubMed

    Brody, Rebecca A; Byham-Gray, Laura; Touger-Decker, Riva; Passannante, Marian R; Rothpletz Puglia, Pamela; O'Sullivan Maillet, Julie

    2014-05-01

    Activities performed by advanced-practice registered dietitian nutritionists (RDNs) have yet to be clearly elucidated. The study aimed to gain consensus on the practice activities of advanced-practice RDNs who provide direct clinical nutrition care. A three-round Delphi study was conducted. Purposive sampling identified 117 RDN experts working as clinicians and/or managers in direct care settings that met inclusion criteria for advanced-level practice. In Round 1, 85 experts provided open-ended advanced-level practice activities linked to the Nutrition Care Process sections. Using content analysis, the responses were coded into activity statements. In Round 2, experts rated the essentiality of these activities. In Round 3, experts re-rated statements not reaching consensus while viewing their previous rating, the group median, and comments. Median ratings of 1.0 to 3.0 were defined as essential, 4.0 were neither essential nor nonessential, and 5.0 to 7.0 were nonessential. Consensus was reached when the interquartile range of responses to each question was <2.0. Seventy-six (89.4%) experts completed all rounds. From 770 comments, 129 activity statements were generated. All statements reached consensus: 97.7% as essential; 0.8% as nonessential; and 1.5% as neither. Of essential activities, 67.5% were highly essential with limited variability (median=1.0; interquartile range≤2.0). Advanced-practice RDNs' tasks are patient-centered and reflect complex care; involve a comprehensive and discriminating approach; are grounded in advanced knowledge and expertise in clinical nutrition; include use of advanced interviewing, education, and counseling strategies; and require communication with patient, families, and the health care team. The high-level of consensus from experts suggest advanced-level clinical nutrition practice exists and can be defined.

  5. The prospects for hybrid electric vehicles, 2005-2020 : results of a Delphi Study.

    SciTech Connect

    Ng, H. K.; Santini, D. J.; Vyas, A. D.

    1999-07-22

    The introduction of Toyota's hybrid electric vehicle (HEV), the Prius, in Japan has generated considerable interest in HEV technology among US automotive experts. In a follow-up survey to Argonne National Laboratory's two-stage Delphi Study on electric and hybrid electric vehicles (EVs and HEVs) during 1994-1996, Argonne researchers gathered the latest opinions of automotive experts on the future ''top-selling'' HEV attributes and costs. The experts predicted that HEVs would have a spark-ignition gasoline engine as a power plant in 2005 and a fuel cell power plant by 2020. The projected 2020 fuel shares were about equal for gasoline and hydrogen, with methanol a distant third. In 2020, HEVs are predicted to have series-drive, moderate battery-alone range and cost significantly more than conventional vehicles (CVs). The HEV is projected to cost 66% more than a $20,000 CV initially and 33% more by 2020. Survey respondents view batteries as the component that contributes the most to the HEV cost increment. The mean projection for battery-alone range is 49 km in 2005, 70 km in 2010, and 92 km in 2020. Responding to a question relating to their personal vision of the most desirable HEV and its likely characteristics when introduced in the US market in the next decade, the experts predicted their ''vision'' HEV to have attributes very similar to those of the ''top-selling'' HEV. However, the ''vision'' HEV would cost significantly less. The experts projected attributes of three leading batteries for HEVs and projected acceleration times on battery power alone. The resulting battery packs are evaluated, and their initial and replacement costs are analyzed. These and several other opinions are summarized.

  6. Prioritization of future research topics for children's hospice care by its key stakeholders: a Delphi study.

    PubMed

    Malcolm, C; Knighting, K; Forbat, L; Kearney, N

    2009-07-01

    The Delphi process, widely used in health research to seek consensus on key issues amongst large stakeholder groups, was adopted to allow families, hospice staff/volunteers and linked professionals to identify and prioritize future research priorities for children's hospice care. In the qualitative Round 1, interviews with families (n = 5), linked professionals (n = 18) and focus groups with hospice staff and volunteers (n = 44) led to the generation of 56 research topics categorised within 14 broad themes. To give a larger number of stakeholders (n = 621) (including families n = 293; hospice staff/volunteers n = 216 and professionals n = 112) the opportunity to rate the importance of each research topic and seek group consensus on the future research priorities for children's hospice care, subsequent Rounds 2 and 3 involved the use of postal questionnaires. Response rates to questionnaires were 44% in Round 2 (274/621) and 83% in Round 3 (204/247). Participants prioritized research topics relating to 1) hospice and respite care needs of young people (aged 16 +), 2) pain and symptom management and 3) bereavement and end-of-life care. There was wide acknowledgement by those took part in the process of the difficulty in rating the topics, and emphasis on the fact that all of the topics raised during the project are of high importance and merit further research. The current salient issues perceived by key stakeholders as being the research priorities for children's hospice care were identified. Addressing these priority topics for research would further contribute to the development of a much needed evidence base in children's hospice and palliative care research and optimise the delivery of children's hospice services that are underpinned by valid and robust research.

  7. Development of Health Equity Indicators in Primary Health Care Organizations Using a Modified Delphi

    PubMed Central

    Wong, Sabrina T.; Browne, Annette J.; Varcoe, Colleen; Lavoie, Josée; Fridkin, Alycia; Smye, Victoria; Godwin, Olive; Tu, David

    2014-01-01

    Objective The purpose of this study was to develop a core set of indicators that could be used for measuring and monitoring the performance of primary health care organizations' capacity and strategies for enhancing equity-oriented care. Methods Indicators were constructed based on a review of the literature and a thematic analysis of interview data with patients and staff (n = 114) using procedures for qualitatively derived data. We used a modified Delphi process where the indicators were circulated to staff at the Health Centers who served as participants (n = 63) over two rounds. Indicators were considered part of a priority set of health equity indicators if they received an overall importance rating of>8.0, on a scale of 1–9, where a higher score meant more importance. Results Seventeen indicators make up the priority set. Items were eliminated because they were rated as low importance (<8.0) in both rounds and were either redundant or more than one participant commented that taking action on the indicator was highly unlikely. In order to achieve health care equity, performance at the organizational level is as important as assessing the performance of staff. Two of the highest rated “treatment” or processes of care indicators reflects the need for culturally safe and trauma and violence-informed care. There are four indicators that can be used to measure outcomes which can be directly attributable to equity responsive primary health care. Discussion These indicators and subsequent development of items can be used to measure equity in the domains of treatment and outcomes. These areas represent targets for higher performance in relation to equity for organizations (e.g., funding allocations to ongoing training in equity-oriented care provision) and providers (e.g., reflexive practice, skill in working with the health effects of trauma). PMID:25478914

  8. Standardised method for reporting exercise programmes: protocol for a modified Delphi study

    PubMed Central

    Slade, Susan C; Dionne, Clermont E; Underwood, Martin; Buchbinder, Rachelle

    2014-01-01

    Introduction Exercise is integral to health across the lifespan and important for people with chronic health conditions. A systematic review of exercise trials for chronic conditions reported suboptimal descriptions of the evaluated interventions and concluded that this hinders interpretation and replication. The aim of this project is to develop a standardised method for reporting essential exercise programme details being evaluated in clinical trials. Methods and analysis A modified Delphi technique will be used to gain consensus among international exercise experts. We will use three sequential rounds of anonymous online questionnaires to refine a standardised checklist. A draft checklist of potentially relevant items was developed based on the results of a systematic review of exercise systematic reviews. An international panel of experts was identified by exercise systematic review authorship, established international profile in exercise research and practice and by peer referral. In round 1, the international panel of experts will be asked to rate the importance of each draft item and provide additional suggestions for revisions or new items. Consensus will be considered reached if at least 70% of the panel strongly agree/disagree that an item should be included or excluded. Where agreement is not reached or there are suggestions for altered or new items, these will be taken to round 2 together with an aggregated summary of round 1 responses. Following the second round, a ranking of item importance will be made to rationalise the number of items. The final template will be distributed to panel members for approval. Ethics and dissemination Ethics approval was received from The Cabrini Institute Ethics Committee, Melbourne, Australia (HREC 02-07-04-14). We plan to use a stepwise process to develop and refine a standardised and internationally agreed template for explicit reporting of exercise programmes. The template will be generalisable across all types of

  9. Building consensus on key priorities for rural health care in South Africa using the Delphi technique

    PubMed Central

    Versteeg, Marije; du Toit, Lilo; Couper, Ian

    2013-01-01

    Background South Africa is currently undergoing major health system restructuring in an attempt to improve health outcomes and reduce inequities in access. Such inequities exist between private and public health care and within the public health system itself. Experience shows that rural health care can be disadvantaged in policy formulation despite good intentions. The objective of this study was to identify the major challenges and priority interventions for rural health care provision in South Africa thereby contributing to pro-rural health policy dialogue. Methods The Delphi technique was used to develop consensus on a list of statements that was generated through interviews and literature review. A panel of rural health practitioners and other stakeholders was asked to indicate their level of agreement with these statements and to rank the top challenges in and interventions required for rural health care. Results Response rates ranged from 83% in the first round (n=44) to 64% in the final round (n=34). The top five priorities were aligned to three of the WHO health system building blocks: human resources for health (HRH), governance, and finance. Specifically, the panel identified a need to focus on recruitment and support of rural health professionals, the employment of managers with sufficient and appropriate skills, a rural-friendly national HRH plan, and equitable funding formulae. Conclusion Specific policies and strategies are required to address the greatest rural health care challenges and to ensure improved access to quality health care in rural South Africa. In addition, a change in organisational climate and a concerted effort to make a career in rural health appealing to health care workers and adequate funding for rural health care provision are essential. PMID:23364081

  10. International perspective on common core competencies for occupational physicians: a modified Delphi study

    PubMed Central

    Lalloo, Drushca; Demou, Evangelia; Kiran, Sibel; Cloeren, Marianne; Mendes, René; Macdonald, Ewan B

    2016-01-01

    Objectives The competencies required of occupational physicians (OPs) have been the subject of peer-reviewed research in Europe and individual countries around the world. In the European Union (EU), there has been development of guidance on training and common competencies, but little research has extended beyond this. The aim of this study was to obtain consensus on and identify the common core competencies required of OPs around the world. Methods A modified Delphi study was carried out among representative organisations and networks of OPs in a range of countries around the world. It was conducted in 2 rounds using a questionnaire based on the specialist training syllabus of a number of countries, expert panel reviews and conference discussions. Results Responses were received from 51 countries around the world, with the majority from Europe (60%; 59%) and North and South America (24%; 32%) in rounds 1 and 2, respectively. General principles of assessment and management of occupational hazards to health and good clinical care were jointly considered most important in ranking when compared with the other topic areas. Assessment of disability and fitness for work, communication skills and legal and ethical issues completed the top five. In both rounds, research methods and teaching and educational supervision were considered least important. Conclusions This study has established the current priorities among OPs across 51 countries of the common competencies required for occupational health (OH) practice. These findings can serve as a platform for the development of common core competencies/qualifications within specific geographical regions or internationally. This is particularly pertinent with globalisation of commerce and free movement within the EU. PMID:27076063

  11. Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus

    PubMed Central

    Arab, Juan P; Claro, Juan C; Arancibia, Juan P; Contreras, Jorge; Gómez, Fernando; Muñoz, Cristian; Nazal, Leyla; Roessler, Eric; Wolff, Rodrigo; Arrese, Marco; Benítez, Carlos

    2016-01-01

    AIM To propose several alternatives treatment of type 1 hepatorenal syndrome (HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension. METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature. Each expert was designated to review and answer a question. They generated draft statements for evaluation by all the experts. Additional input was obtained from medical community. In order to reach consensus, a modified three-round Delphi technique method was used. According to United States Preventive Services Task Force criteria, the quality of the evidence and level of recommendation supporting each statement was graded. RESULTS Nine questions were formulated. The available evidence was evaluated considering its quality, number of patients included in the studies and the consistency of its results. The generated questions were answered by the expert panel with a high level of agreement. Thus, a therapeutic algorithm was generated. The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice. On the other hand the use of the combination of octreotide, midodrine and albumin without vasoconstrictors was discouraged. The role of several other options was also evaluated and the available evidence was explored and discussed. Liver transplantation is considered the definitive treatment for HRS-1. The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature, the quality of the evidence and the benefits, adverse effects and availability of the therapeutic tools described. CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1.

  12. An algorithm for tailoring pharmacotherapy for smoking cessation: results from a Delphi panel of international experts

    PubMed Central

    Bader, P; McDonald, P; Selby, P

    2009-01-01

    Background: Evidence-based smoking cessation guidelines recommend nicotine replacement therapy (NRT), bupropion SR and varenicline as first-line therapy in combination with behavioural interventions. However, there are limited data to guide clinicians in recommending one form over another, using combinations, or matching individual smokers to particular forms. Objective: To develop decision rules for clinicians to guide differential prescribing practices and tailoring of pharmacotherapy for smoking cessation. Methods: A Delphi approach was used to build consensus among a panel of 37 international experts from various health disciplines. Through an iterative process, panellists responded to three rounds of questionnaires. Participants identified and ranked “best practices” used by them to tailor pharmacotherapy to aid smoking cessation. An independent panel of 10 experts provided cross-validation of findings. Results: There was a 100% response rate to all three rounds. A high level of consensus was achieved in determining the most important priorities: (1) factors to consider in prescribing pharmacotherapy: evidence, patient preference, patient experience; (2) combinations based on: failed attempt with monotherapy, patients with breakthrough cravings, level of tobacco dependence; (3) specific combinations, main categories: (a) two or more forms of NRT, (b) bupropion + form of NRT; (4) specific combinations, subcategories: (1a) patch + gum, (1b) patch + inhaler, (1c) patch + lozenge; (2a) bupropion + patch, (2b) bupropion + gum; (5) impact of comorbidities on selection of pharmacotherapy: contraindications, specific pharmacotherapy useful for certain comorbidities, dual purpose medications; (6) frequency of monitoring determined by patient needs and type of pharmacotherapy. Conclusion: An algorithm and guide were developed to assist clinicians in prescribing pharmacotherapy for smoking cessation. There appears to be good justification for “off-label” use such

  13. Incorporating the Delphi Technique to investigate renewable energy technology transfer in Saudi Arabia

    NASA Astrophysics Data System (ADS)

    Al-Otaibi, Nasir K.

    Saudi Arabia is a major oil-producing nation facing a rapidly-growing population, high unemployment, climate change, and the depletion of its natural resources, potentially including its oil supply. Technology transfer is regarded as a means to diversify countries' economies beyond their natural resources. This dissertation examined the opportunities and barriers to utilizing technology transfer successfully to build renewable energy resources in Saudi Arabia to diversify the economy beyond oil production. Examples of other developing countries that have successfully used technology transfer to transform their economies are explored, including Japan, Malayasia, and the United Arab Emirates. Brazil is presented as a detailed case study to illustrate its transition to an economy based to a much greater degree than before on renewable energy. Following a pilot study, the Delphi Method was used in this research to gather the opinions of a panel of technology transfer experts consisting of 10 heterogeneous members of different institutions in the Kingdom of Saudi Arabia, including aviation, telecommunication, oil industry, education, health systems, and military and governmental organizations. In three rounds of questioning, the experts identified Education, Dependence on Oil, and Manpower as the 3 most significant factors influencing the potential for success of renewable energy technology transfer for Saudi Arabia. Political factors were also rated toward the "Very Important" end of a Likert scale and were discussed as they impact Education, Oil Dependence, and Manpower. The experts' opinions are presented and interpreted. They form the basis for recommended future research and discussion of how in light of its political system and its dependence on oil, Saudi Arabia can realistically move forward on renewable energy technology transfer and secure its economic future.

  14. Identifying Markers of Dignity-Conserving Care in Long-Term Care: A Modified Delphi Study

    PubMed Central

    Thompson, Genevieve N.; McArthur, Jennifer; Doupe, Malcolm

    2016-01-01

    Ensuring that people living in nursing homes (NHs) are afforded with dignity in their daily lives is an essential and humane concern. Promoting dignity-conserving care is fundamentally important. By nature, however, this care is all-encompassing and holistic, and from current knowledge it is challenging to create explicit strategies for measuring dignity-conserving care. In practice the majority of current NH indicators of quality care are derived from information that is routinely collected on NH residents using the RAI-Minimum Data Set (MDS). In this regard, issues that are more tangible to resident dignity such as being treated with respect, compassion, and having opportunities to engage with others are not adequately captured in current NH quality of care indicators. An initial set of markers was created by conducting an integrative literature review of existing markers and indicators of dignity in the NH setting. A modified Delphi process was used to prioritize essential dignity-conserving care markers for use by NH providers, based on factors such as the importance to fostering a culture of dignity, the impact it may have on the residents, and how achievable it is in practice. Through this consensus building technique, we were able to develop a comprehensive set of markers that capture the range and diversity of important dignity-conserving care strategies for use in NHs. The final 10 markers were judged as having high face validity by experts in the field and have explicit implications for enhancing the provision of daily dignified care to NH residents. These markers make an important addition to the traditional quality indicators used in the NH setting and as such, bridge an important gap in addressing the psychosocial and the less easily quantified needs of NH residents. PMID:27304853

  15. Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus

    PubMed Central

    Rollan, Antonio; Arab, Juan Pablo; Camargo, M Constanza; Candia, Roberto; Harris, Paul; Ferreccio, Catterina; Rabkin, Charles S; Gana, Juan Cristóbal; Cortés, Pablo; Herrero, Rolando; Durán, Luisa; García, Apolinaria; Toledo, Claudio; Espino, Alberto; Lustig, Nicole; Sarfatis, Alberto; Figueroa, Catalina; Torres, Javier; Riquelme, Arnoldo

    2014-01-01

    AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature. METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria. RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included: (1) when available, urea breath and stool antigen test (HpSA) should be used for non-invasive diagnosis; (2) detect and eradicate Helicobacter pylori (H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer; (3) further investigate implementation issues and health outcomes of H. pylori eradication for primary prevention of gastric cancer in high-risk populations; (4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment; (5) routinely assess eradication success post-treatment in clinical settings; and (6) select second- and third-line therapies according to antibiotic susceptibility testing. CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. PMID:25152601

  16. CATALISE: A Multinational and Multidisciplinary Delphi Consensus Study. Identifying Language Impairments in Children

    PubMed Central

    Snowling, Margaret J.; Thompson, Paul A.; Greenhalgh, Trisha

    2016-01-01

    Delayed or impaired language development is a common developmental concern, yet there is little agreement about the criteria used to identify and classify language impairments in children. Children's language difficulties are at the interface between education, medicine and the allied professions, who may all adopt different approaches to conceptualising them. Our goal in this study was to use an online Delphi technique to see whether it was possible to achieve consensus among professionals on appropriate criteria for identifying children who might benefit from specialist services. We recruited a panel of 59 experts representing ten disciplines (including education, psychology, speech-language therapy/pathology, paediatrics and child psychiatry) from English-speaking countries (Australia, Canada, Ireland, New Zealand, United Kingdom and USA). The starting point for round 1 was a set of 46 statements based on articles and commentaries in a special issue of a journal focusing on this topic. Panel members rated each statement for both relevance and validity on a seven-point scale, and added free text comments. These responses were synthesised by the first two authors, who then removed, combined or modified items with a view to improving consensus. The resulting set of statements was returned to the panel for a second evaluation (round 2). Consensus (percentage reporting 'agree' or 'strongly agree') was at least 80 percent for 24 of 27 round 2 statements, though many respondents qualified their response with written comments. These were again synthesised by the first two authors. The resulting consensus statement is reported here, with additional summary of relevant evidence, and a concluding commentary on residual disagreements and gaps in the evidence base. PMID:27392128

  17. Key components of anaphylaxis management plans: consensus findings from a national electronic Delphi study

    PubMed Central

    Worth, Allison; Nurmatov, Ulugbek; Sheikh, Aziz

    2010-01-01

    Objectives There is no international consensus on the components of anaphylaxis management plans and responsibility for their design and delivery is contested. We set out to establish consensus among relevant specialist and generalist clinicians on this issue to inform future randomized controlled trials. Design A two-round electronic Delphi study completed by a 25-person, multidisciplinary expert panel. Participants scored the importance of a range of statements on anaphylaxis management, identified from a systematic review of the literature, on a five-point scale ranging from ‘very important’ to ‘irrelevant’. Consensus was defined a priori as being achieved if 80% or more of panel members rated a statement as ‘important’ or ‘very important’ after Round 2. Setting Primary and secondary care and academic settings in the UK and Ireland. Participants Twenty-five medical, nursing and allied health professionals. Main outcome measures Consensus on the key components of anaphylaxis management plans. Results The response rate was 84% (n = 21) for Round 1 and 96% (n = 24) for Round 2. The key components of emergency care on which consensus was achieved included: awareness of trigger factors (100%); recognition and emergency management of reactions of different severity (100%); and clear information on adrenaline (epinephrine) use (100%). Consensus on longer-term management issues included: clear written guidelines on anaphylaxis management (96%); annual review of plans (87%); and plans that were tailored to individual needs (82%). Conclusions This national consensus-building exercise generated widespread agreement that emergency plans need to be simple, clear and generic, making them easy to implement in a crisis. In contrast, long-term plans need to be negotiated between patient/carers and professionals, and tailored to individual needs. The effectiveness of this expert-agreed long-term plan now needs to be evaluated rigorously. PMID:21103134

  18. Identifying Markers of Dignity-Conserving Care in Long-Term Care: A Modified Delphi Study.

    PubMed

    Thompson, Genevieve N; McArthur, Jennifer; Doupe, Malcolm

    2016-01-01

    Ensuring that people living in nursing homes (NHs) are afforded with dignity in their daily lives is an essential and humane concern. Promoting dignity-conserving care is fundamentally important. By nature, however, this care is all-encompassing and holistic, and from current knowledge it is challenging to create explicit strategies for measuring dignity-conserving care. In practice the majority of current NH indicators of quality care are derived from information that is routinely collected on NH residents using the RAI-Minimum Data Set (MDS). In this regard, issues that are more tangible to resident dignity such as being treated with respect, compassion, and having opportunities to engage with others are not adequately captured in current NH quality of care indicators. An initial set of markers was created by conducting an integrative literature review of existing markers and indicators of dignity in the NH setting. A modified Delphi process was used to prioritize essential dignity-conserving care markers for use by NH providers, based on factors such as the importance to fostering a culture of dignity, the impact it may have on the residents, and how achievable it is in practice. Through this consensus building technique, we were able to develop a comprehensive set of markers that capture the range and diversity of important dignity-conserving care strategies for use in NHs. The final 10 markers were judged as having high face validity by experts in the field and have explicit implications for enhancing the provision of daily dignified care to NH residents. These markers make an important addition to the traditional quality indicators used in the NH setting and as such, bridge an important gap in addressing the psychosocial and the less easily quantified needs of NH residents. PMID:27304853

  19. Development of mental health first aid guidelines for suicidal ideation and behaviour: A Delphi study

    PubMed Central

    Kelly, Claire M; Jorm, Anthony F; Kitchener, Betty A; Langlands, Robyn L

    2008-01-01

    Background Suicide is a statistically rare event, but devastating to those left behind and one of the worst possible outcomes associated with mental illness. Although a friend, family member or co-worker may be the first person to notice that a person is highly distressed, few have the knowledge and skills required to assist. Simple guidelines may help such a person to encourage a suicidal individual to seek professional help or decide against suicide. Methods This research was conducted using the Delphi methodology, a method of reaching consensus in a panel of experts. Experts recruited to the panels included 22 professionals, 10 people who had been suicidal in the past and 6 carers of people who had been suicidal in the past. Statements about how to assist someone who is thinking about suicide were sourced through a systematic search of both professional and lay literature. The guidelines were written using the items most consistently endorsed by all three panels. Results Of 114 statements presented to the panels, 30 were accepted. These statements were used to develop the guidelines appended to this paper. Conclusion There are a number of actions which are considered to be useful for members of the public when they encounter someone who is experiencing suicidal thoughts or engaging in suicidal behaviour. These guidelines will be useful in revision of curricula of mental health first aid and suicide intervention training programs. They can also be used by members of the public who want immediate information about how to assist a suicidal person. PMID:18366657

  20. Development of mental health first aid guidelines for panic attacks: a Delphi study

    PubMed Central

    Kelly, Claire M; Jorm, Anthony F; Kitchener, Betty A

    2009-01-01

    Background Panic attacks are common, and while they are not life-threatening events, they can lead to the development of panic disorder and agoraphobia. Appropriate help at the time that a panic attack occurs may decrease the fear associated with the attack and reduce the risk of developing an anxiety disorder. However, few people have the knowledge and skills required to assist. Simple first aid guidelines may help members of the public to offer help to people who experience panic attacks. Methods The Delphi method was used to reach consensus in a panel of experts. Experts included 50 professionals and 6 people who had experience of panic attacks and were active in mental health advocacy. Statements about how to assist someone who is having a panic attack were sourced through a systematic search of both professional and lay literature. These statements were rated for importance as first aid guidelines by the expert and consumer panels and guidelines were written using the items most consistently endorsed. Results Of 144 statements presented to the panels, 27 were accepted. These statements were used to develop the guidelines appended to this paper. Conclusion There are a number of actions which are considered to be useful for members of the public to do if they encounter someone who is having a panic attack. These guidelines will be useful in revision of curricula of mental health first aid programs. They can also be used by members of the public who want immediate information about how to assist someone who is experiencing panic attacks. PMID:19664244

  1. CATALISE: A Multinational and Multidisciplinary Delphi Consensus Study. Identifying Language Impairments in Children.

    PubMed

    Bishop, D V M; Snowling, Margaret J; Thompson, Paul A; Greenhalgh, Trisha

    2016-01-01

    Delayed or impaired language development is a common developmental concern, yet there is little agreement about the criteria used to identify and classify language impairments in children. Children's language difficulties are at the interface between education, medicine and the allied professions, who may all adopt different approaches to conceptualising them. Our goal in this study was to use an online Delphi technique to see whether it was possible to achieve consensus among professionals on appropriate criteria for identifying children who might benefit from specialist services. We recruited a panel of 59 experts representing ten disciplines (including education, psychology, speech-language therapy/pathology, paediatrics and child psychiatry) from English-speaking countries (Australia, Canada, Ireland, New Zealand, United Kingdom and USA). The starting point for round 1 was a set of 46 statements based on articles and commentaries in a special issue of a journal focusing on this topic. Panel members rated each statement for both relevance and validity on a seven-point scale, and added free text comments. These responses were synthesised by the first two authors, who then removed, combined or modified items with a view to improving consensus. The resulting set of statements was returned to the panel for a second evaluation (round 2). Consensus (percentage reporting 'agree' or 'strongly agree') was at least 80 percent for 24 of 27 round 2 statements, though many respondents qualified their response with written comments. These were again synthesised by the first two authors. The resulting consensus statement is reported here, with additional summary of relevant evidence, and a concluding commentary on residual disagreements and gaps in the evidence base. PMID:27392128

  2. Common Dolphin (Delphinus delphis) Bycatch in New Zealand Commercial Trawl Fisheries

    PubMed Central

    Thompson, Finlay N.; Abraham, Edward R.; Berkenbusch, Katrin

    2013-01-01

    Marine mammals are regularly reported as bycatch in commercial and artisanal fisheries, but data are often insufficient to allow assessment of these incidental mortalities. Observer coverage of the mackerel trawl fishery in New Zealand waters between 1995 and 2011 allowed evaluation of common dolphin Delphinus delphis bycatch on the North Island west coast, where this species is the most frequently caught cetacean. Observer data were used to develop a statistical model to estimate total captures and explore covariates related to captures. A two-stage Bayesian hurdle model was used, with a logistic generalised linear model predicting whether any common dolphin captures occurred on a given tow of the net, and a zero-truncated Poisson distribution to estimate the number of dolphin captures, given that there was a capture event. Over the 16-year study period, there were 119 common dolphin captures reported on 4299 observed tows. Capture events frequently involved more than one individual, with a maximum of nine common dolphin observed caught in a single tow. There was a peak of 141 estimated common dolphin captures (95% c.i.: 56 to 276; 6.27 captures per 100 tows) in 2002–03, following the marked expansion in annual effort in this fishery to over 2000 tows. Subsequently, the number of captures fluctuated although fishing effort remained relatively high. Of the observed capture events, 60% were during trawls where the top of the net (headline) was <40 m below the surface, and the model determined that this covariate best explained common dolphin captures. Increasing headline depth by 21 m would halve the probability of a dolphin capture event on a tow. While lack of abundance data prevents assessment of the impact of these mortalities on the local common dolphin population, a clear recommendation from this study is the increasing of headline depth to reduce common dolphin captures. PMID:23717614

  3. Case complexity in patients with chronic nonspecific musculoskeletal pain: a Delphi and feasibility study.

    PubMed

    Waterschoot, Franka P C; Bennen, Elseline; van der Woude, Lucas H V; Schiphorst Preuper, Henrica R; Reneman, Michiel F

    2016-03-01

    Assessment of case complexity in patients with chronic nonspecific musculoskeletal pain (CMP) is currently clinician based, not transparent, and with low reliability. The objective of this study was to explore case complexity and to initiate the development of a case complexity index (CCI). A three-round Delphi study among clinicians involved in multidisciplinary Pain Rehabilitation Programs was performed to identify important factors that are assumed to influence functioning in patients with CMP. The 10 most important factors were used to initiate the development of a CCI, with mean ratings of importance per factor as weights. The feasibility of the CCI was tested in a pilot study on 16 patients with CMP. In the first round, 166 factors were identified; in the second round, the 10 most important factors were selected; in the third round, relative weights of each factor were calculated, ranging from 1.75 (features of complaints) to 3.56 (psychiatric disorders) on a scale from 0 (no weight) to 4 (very heavy weight). The assessments for the factors were mainly based on clinical examination and reasoning. Clinicians could rate all patients using the CCI, which confirmed feasibility of the CCI. Ten, mainly psychosocial, factors were identified, which were assumed to be most important for the assessment of case complexity in a patient with CMP. With these factors, a CCI was created, for which feasibility was established. This CCI is transparent, easy to use, and might provide a basis for further development of a structured assessment of case complexity, which may have scientific and clinical relevance.

  4. Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus

    PubMed Central

    Arab, Juan P; Claro, Juan C; Arancibia, Juan P; Contreras, Jorge; Gómez, Fernando; Muñoz, Cristian; Nazal, Leyla; Roessler, Eric; Wolff, Rodrigo; Arrese, Marco; Benítez, Carlos

    2016-01-01

    AIM To propose several alternatives treatment of type 1 hepatorenal syndrome (HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension. METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature. Each expert was designated to review and answer a question. They generated draft statements for evaluation by all the experts. Additional input was obtained from medical community. In order to reach consensus, a modified three-round Delphi technique method was used. According to United States Preventive Services Task Force criteria, the quality of the evidence and level of recommendation supporting each statement was graded. RESULTS Nine questions were formulated. The available evidence was evaluated considering its quality, number of patients included in the studies and the consistency of its results. The generated questions were answered by the expert panel with a high level of agreement. Thus, a therapeutic algorithm was generated. The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice. On the other hand the use of the combination of octreotide, midodrine and albumin without vasoconstrictors was discouraged. The role of several other options was also evaluated and the available evidence was explored and discussed. Liver transplantation is considered the definitive treatment for HRS-1. The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature, the quality of the evidence and the benefits, adverse effects and availability of the therapeutic tools described. CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. PMID:27660674

  5. Determining an Imaging Literacy Curriculum for Radiation Oncologists: An International Delphi Study

    SciTech Connect

    Giuliani, Meredith E.; Gillan, Caitlin; Milne, Robin A.; Uchino, Minako; Millar, Barbara-Ann; Catton, Pamela

    2014-03-15

    Purpose: Rapid evolution of imaging technologies and their integration into radiation therapy practice demands that radiation oncology (RO) training curricula be updated. The purpose of this study was to develop an entry-to-practice image literacy competency profile. Methods and Materials: A list of 263 potential imaging competency items were assembled from international objectives of training. Expert panel eliminated redundant or irrelevant items to create a list of 97 unique potential competency items. An international 2-round Delphi process was conducted with experts in RO. In round 1, all experts scored, on a 9-point Likert scale, the degree to which they agreed an item should be included in the competency profile. Items with a mean score ≥7 were included, those 4 to 6 were reviewed in round 2, and items scored <4 were excluded. In round 2, items were discussed and subsequently ranked for inclusion or exclusion in the competency profile. Items with >75% voting for inclusion were included in the final competency profile. Results: Forty-nine radiation oncologists were invited to participate in round 1, and 32 (65%) did so. Participants represented 24 centers in 6 countries. Of the 97 items ranked in round 1, 80 had a mean score ≥7, 1 item had a score <4, and 16 items with a mean score of 4 to 6 were reviewed and rescored in round 2. In round 2, 4 items had >75% of participants voting for inclusion and were included; the remaining 12 were excluded. The final list of 84 items formed the final competency profile. The 84 enabling competency items were aggregated into the following 4 thematic groups of key competencies: (1) imaging fundamentals (42 items); (2) clinical application (27 items); (3) clinical management (5 items); and (4) professional practice (10 items). Conclusions: We present an imaging literacy competency profile which could constitute the minimum training standards in radiation oncology residency programs.

  6. Determining organisation-specific factors for developing health interventions in companies by a Delphi procedure: Organisational Mapping.

    PubMed

    van Scheppingen, Arjella R; ten Have, Kristin C J M; Zwetsloot, Gerard J I M; Kok, Gerjo; van Mechelen, Willem

    2015-12-01

    Companies, seen as social communities, are major health promotion contexts. However, health promotion in the work setting is often less successful than intended. An optimal adjustment to the organisational context is required. Knowledge of which organisation-specific factors are relevant to health promotion is scarce. A Delphi procedure is used to identify these factors. The aim is to contribute to more effective workplace health promotion. The identified factors are described and embedded into a practical methodology (Intervention Mapping). A systematic use of these factors (called 'Organisational Mapping') is likely to contribute to more effective health promotion in the work setting.

  7. Determining organisation-specific factors for developing health interventions in companies by a Delphi procedure: Organisational Mapping.

    PubMed

    van Scheppingen, Arjella R; ten Have, Kristin C J M; Zwetsloot, Gerard J I M; Kok, Gerjo; van Mechelen, Willem

    2015-12-01

    Companies, seen as social communities, are major health promotion contexts. However, health promotion in the work setting is often less successful than intended. An optimal adjustment to the organisational context is required. Knowledge of which organisation-specific factors are relevant to health promotion is scarce. A Delphi procedure is used to identify these factors. The aim is to contribute to more effective workplace health promotion. The identified factors are described and embedded into a practical methodology (Intervention Mapping). A systematic use of these factors (called 'Organisational Mapping') is likely to contribute to more effective health promotion in the work setting. PMID:26573181

  8. Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells

    PubMed Central

    Sumiyoshi, Tetsutaro; Sato, Kaoru; Yamamoto, Hitomi; Iwasaki, Yuka W.; Siomi, Haruhiko; Siomi, Mikiko C.

    2016-01-01

    In Drosophila germ cells, PIWI-interacting RNAs (piRNAs) are amplified through a PIWI slicer-dependent feed-forward loop termed the ping-pong cycle, yielding secondary piRNAs. However, the detailed mechanism remains poorly understood, largely because an ex vivo model system amenable to biochemical analyses has not been available. Here, we show that CRISPR-mediated loss of function of lethal (3) malignant brain tumor [l(3)mbt] leads to ectopic activation of the germ-specific ping-pong cycle in ovarian somatic cells. Perinuclear foci resembling nuage, the ping-pong center, appeared following l(3)mbt mutation. This activation of the ping-pong machinery in cultured cells will greatly facilitate elucidation of the mechanism underlying secondary piRNA biogenesis in Drosophila. PMID:27474440

  9. Application of RELAP5/MOD3.1 code to the LOFT test L3-6

    SciTech Connect

    Pylev, S.S.; Roginskaja, V.L.

    1998-02-01

    A calculation of LOFT Experiment L3-6, a small break equivalent to a 4-in diameter rupture in the cold leg of a four-loop commercial pressurized water reactor, has been performed to help validate RELAP5/MOD3.1 for this application. The version of the code to be used is SCDAP/RELAP5/MOD3.1.8d0. Three calculations were carried out in order to study the sensitivity to change break nozzle superheated discharge coefficient. Conducted comparative analysis of the LOFT L3-6 experiment shows on the whole a reasonable agreement between calculated data. Some discrepancies in the system pressure do not distort a picture of the transient. 6 refs.

  10. USCA, a codeveloped piece of technology, is presented to Bridges, KSC Director, by Saputo, L-3 Commu

    NASA Technical Reports Server (NTRS)

    1997-01-01

    William Saputo, L-3 Communications, presents a new piece of technology, developed through a National Aeronautics and Space Administration (NASA) partnership with industry, to Kennedy Space Center (KSC) Director Roy Bridges, Jr. (second from left). The piece of technology being presented, the Universal Signal Conditioning Amplifier (USCA), is a key component of the codeveloped Automated Data Acquisition System (ADAS) that measures temperature, pressure and vibration at KSC's launch pads. The breakthrough technology is expected to reduce sensor setup and configuration times from hours to seconds. KSC teamed up with Florida's Technological Research and Development Authority and manufacturer L-3 Communications to produce a system that would benefit the aerospace industry and other commercial markets.

  11. The cyanelle genome of Cyanophora paradoxa, unlike the chloroplast genome, codes for the ribosomal L3 protein.

    PubMed Central

    Evrard, J L; Johnson, C; Janssen, I; Löffelhardt, W; Weil, J H; Kuntz, M

    1990-01-01

    We describe a 1132 bp sequence of the cyanelle genome of Cyanophora paradoxa containing the rpl3 gene. This gene, which is not chloroplast encoded in plants, is the first of a long cyanelle ribosomal operon whose organization resembles that of the S10 operon of E. coli. We have shown that the rpl3 gene is transcribed in cyanelles as a 7500 nucleotide precursor and that the 5'-end of the mRNA starts approximately 90 nucleotides upstream from the initiation codon. However, no typical procaryotic promoter could be found for this gene. We have detected, using anti E. coli L3 antibodies, the cyanelle L3 protein in cyanelle extracts and in E. coli cells transformed with the cyanelle rpl3 gene. Images PMID:2108429

  12. Combined results on b-hadron production rates, lifetimes, oscillations and semileptonic decays

    SciTech Connect

    WIllocq, stephane

    2000-08-02

    Combined results on b-hadron lifetimes, b-hadron production rates B{sub d}{sup 0}--Anti-B{sub d}{sup 0} and B{sub s}{sup 0}--Anti-B{sub s}{sup 0} oscillations, the decay width difference between the mass eigenstates of the B{sub s}{sup 0}--Anti-B{sub s}{sup 0} system, and the values of the CKM matrix elements {vert_bar}V{sub cb}{vert_bar} and {vert_bar}V{sub ub}{vert_bar} are obtained from published and preliminary measurements available in Summer 99 from the ALEPH, CDF, DELPHI, L3, OPAL and SLD Collaborations.

  13. Combined Results on b-Hadron Production Rates and Decay Properties

    SciTech Connect

    Su, Dong

    2002-09-11

    Combined results on b-hadron lifetimes, b-hadron production rates, B{sub d}{sup 0}-{bar B}{sub d}{sup 0} and B{sub s}{sup 0}-{bar B}{sub s}{sup 0} oscillations, the decay width difference between the mass eigenstates of the B{sub s}{sup 0}-{bar B}{sub s}{sup 0} system, the average number of c and {bar c} quarks in b-hadron decays, and searches for CP violation in the B{sub d}{sup 0}-{bar B}{sub d}{sup 0} system are presented. They have been obtained from published and preliminary measurements available in Summer 2000 from the ALEPH, CDF, DELPHI, L3, OPAL and SLD Collaborations. These results have been used to determine the parameters of the CKM unitarity triangle.

  14. Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells

    PubMed Central

    Niwa, Yuki; Suzuki, Takehiro; Dohmae, Naoshi; Simizu, Siro

    2016-01-01

    R-spondin1 (Rspo1) is a secreted protein that enhances Wnt signaling, which has crucial functions in embryonic development and several cancers. C-mannosylation is a rare type of glycosylation and might regulate secretion, protein–protein interactions, and enzymatic activity. Although human Rspo1 contains 2 predicted C-mannosylation sites, C-mannosylation of Rspo1 has not been reported, nor have its functional effects on this protein. In this study, we demonstrate by mass spectrometry that Rspo1 is C-mannosylated at W153 and W156. Using Lec15.2 cells, which lack dolichol-phosphate-mannose synthesis activity, and mutant Rspo1-expressing cells that replace W153 and W156 by alanine residues, we observed that C-mannosylation of Rspo1 is required for its secretion. Further, the enhancement of canonical Wnt signaling by Rspo1 is regulated by C-mannosylation. Recently DPY19 was reported to be a C-mannosyltransferase in Caenorhabditis elegans, but no C-mannosyltransferases have been identified in any other organism. In gain- and loss-of-function experiments, human DPY19L3 selectively modified Rspo1 at W156 but not W153 based on mass spectrometry. Moreover, knockdown of DPY19L3 inhibited the secretion of Rspo1. In conclusion, we identified DPY19L3 as the C-mannosyltransferase of Rspo1 at W156 and found that DPY19L3-mediated C-mannosylation of Rspo1 at W156 is required for its secretion. PMID:26764097

  15. The design and construction of a double-sided Silicon Microvertex Detector for the L3 experiment at CERN

    SciTech Connect

    Adam, A.; Ahlen, S.; Marin, A.; Zhou, B.; Ambrosi, G.; Babucci, E.; Bertucci, B.; Biasini, M.; Bilei, G.M.; Caria, M.; Checcucci, B.; Easo, S.; Fiandrini, E.; Krastev, V.R.; Massetti, R.; Pauluzzi, M.; Santocchia, A.; Servoli, L. |; Bencze, G.Y.L.; Kornis, J.; Toth, J.; Brooks, M.L.; Coan, T.E.; Kapustinsky, J.S.; Kinnison, W.W.; Lee, D.M.; Mills, G.B.; Thompson, T.C.; Busenitz, J.; DiBitonto, D.; Camps, C.; Commichau, V.; Hangartner, K.; Schmitz, P.; Castellini, G.; Hauviller, C.; Herve, A.; Josa, I.; Landi, G.; Lecomte, P.; Viertel, G.M.; Waldmeier, S.; Leiste, R. |; Lejeune, E.; Weill, R.; Lohmann, W.; Nowak, H.; Sachwitz, M.; Schoeniech, B.; Tonisch, F.; Trowitzsch, G.; Vogt, H.; Passaleva, G.

    1993-12-01

    A Silicon Microvertex Detector (SMD) has been commissioned for the L3 experiment at the Large Electron-Positron colliding-beam accelerator (LEP) at the European Center for Nuclear Physics, (CERN). The SMD is a 72,672 channel, two layer barrel tracker that is comprised of 96 ac-coupled, double-sided silicon detectors. Details of the design and construction are presented.

  16. A Novel Biosurfactant Produced by Aureobasidium pullulans L3-GPY from a Tiger Lily Wild Flower, Lilium lancifolium Thunb.

    PubMed Central

    Kim, Jong Shik; Lee, In Kyoung; Yun, Bong Sik

    2015-01-01

    Yeast biosurfactants are important biotechnological products in the food industry, and they have medical and cosmeceutical applications owing to their specific modes of action, low toxicity, and applicability. Thus, we have isolated and examined biosurfactant-producing yeast for various industrial and medical applications. A rapid and simple method was developed to screen biosurfactant-producing yeasts for high production of eco-friendly biosurfactants. Using this method, several potential niches of biosurfactant-producing yeasts, such as wild flowers, were investigated. We successfully selected a yeast strain, L3-GPY, with potent surfactant activity from a tiger lily, Lilium lancifolium Thunb. Here, we report the first identification of strain L3-GPY as the black yeast Aureobasidium pullulans. In addition, we isolated a new low-surface-tension chemical, designated glycerol-liamocin, from the culture supernatant of strain L3-GPY through consecutive chromatography steps, involving an ODS column, solvent partition, silica gel, Sephadex LH-20, and an ODS Sep-Pak cartridge column. The chemical structure of glycerol-liamocin, determined by mass spectrometry and nuclear magnetic resonance spectroscopy, indicates that it is a novel compound with the molecular formula C33H62O12. Furthermore, glycerol-liamocin exhibited potent biosurfactant activity (31 mN/m). These results suggest that glycerol-liamocin is a potential novel biosurfactantfor use in various industrial applications. PMID:25849549

  17. Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3.

    PubMed

    García-Gómez, Juan J; Fernández-Pevida, Antonio; Lebaron, Simon; Rosado, Iván V; Tollervey, David; Kressler, Dieter; de la Cruz, Jesús

    2014-03-01

    Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. We report that the rpl3[W255C] allele, which affects the affinity and function of translation elongation factors, impairs cytoplasmic maturation of 20S pre-rRNA. This was not seen for other mutations in or depletion of L3 or other 60S ribosomal proteins. Surprisingly, pre-40S particles containing 20S pre-rRNA form translation-competent 80S ribosomes, and translation inhibition partially suppresses 20S pre-rRNA accumulation. The GTP-dependent translation initiation factor Fun12 (yeast eIF5B) shows similar in vivo binding to ribosomal particles from wild-type and rpl3[W255C] cells. However, the GTPase activity of eIF5B failed to stimulate processing of 20S pre-rRNA when assayed with ribosomal particles purified from rpl3[W255C] cells. We conclude that L3 plays an important role in the function of eIF5B in stimulating 3' end processing of 18S rRNA in the context of 80S ribosomes that have not yet engaged in translation. These findings indicate that the correct conformation of the GTPase activation region is assessed in a quality control step during maturation of cytoplasmic pre-ribosomal particles.

  18. Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53.

    PubMed

    Russo, Annapina; Pagliara, Valentina; Albano, Francesco; Esposito, Davide; Sagar, Vinay; Loreni, Fabrizio; Irace, Carlo; Santamaria, Rita; Russo, Giulia

    2016-01-01

    Many chemotherapeutic drugs cause nucleolar stress and p53-independent pathways mediating the nucleolar stress response are emerging. Here, we demonstrate that ribosomal stress induced by Actinomycin D (Act D) is associated to the up-regulation of ribosomal protein L3 (rpL3) and its accumulation as ribosome-free form in lung and colon cancer cell lines devoid of p53. Free rpL3 regulates p21 expression at transcriptional and post-translational levels through a molecular mechanism involving extracellular-signal-regulated kinases1/2 (ERK1/2) and mouse double minute-2 homolog (MDM2). Our data reveal that rpL3 participates to cell response acting as a critical regulator of apoptosis and cell migration. It is noteworthy that silencing of rpL3 abolishes the cytotoxic effects of Act D suggesting that the loss of rpL3 makes chemotherapy drugs ineffective while rpL3 overexpression associates to a strong increase of Act D-mediated inhibition of cell migration. Taking together our results show that the efficacy of Act D chemotherapy depends on rpL3 status revealing new specific targets involved in the molecular pathways activated by Act D in cancers lacking of p53. Hence, the development of treatments aimed at upregulating rpL3 may be beneficial for the treatment of these cancers.

  19. A delphi study to detect deficiencies and propose actions in real life treatment of neovascular age-related macular degeneration.

    PubMed

    García-Layana, Alfredo; Arias, Luis; Figueroa, Marta S; Araiz, Javier; Ruiz-Moreno, José María; García-Arumí, José; Gómez-Ulla, Francisco; López-Gálvez, María Isabel; Cabrera-López, Francisco; García-Campos, José Manuel; Monés, Jordi; Cervera, Enrique; Armadá, Felix; Gallego-Pinazo, Roberto; Piñero-Bustamante, Antonio; Serrano-Garcia, Miguel Angel

    2014-01-01

    Purpose. Spanish retina specialists were surveyed in order to propose actions to decrease deficiencies in real-life neovascular age macular degeneration treatment (nv-AMD). Methods. One hundred experts, members of the Spanish Vitreoretinal Society (SERV), were invited to complete an online survey of 52 statements about nv-AMD management with a modified Delphi methodology. Four rounds were performed using a 5-point Linkert scale. Recommendations were developed after analyzing the differences between the results and the SERV guidelines recommendations. Results. Eighty-seven specialists completed all the Delphi rounds. Once major potential deficiencies in real-life nv-AMD treatment were identified, 15 recommendations were developed with a high level of agreement. Consensus statements to reduce the burden of the disease included the use of treat and extend regimen and to reduce the amount of diagnostic tests during the loading phase and training technical staff to perform these tests and reduce the time between relapse detection and reinjection, as well as establishing patient referral protocols to outside general ophthalmology clinics. Conclusion. The level of agreement with the final recommendations for nv-AMD treatment among Spanish retinal specialist was high indicating that some actions could be applied in order to reduce the deficiencies in real-life nv-AMD treatment. PMID:25587438

  20. Using the Delphi Approach to Identify Priority Areas for Health Visiting Practice in an Area of Deprivation

    PubMed Central

    Bryar, Rosamund; Anto-Awuakye, Sandra; Christie, Janice; Davis, Claire; Plumb, Karen

    2013-01-01

    Families with children living in areas of high deprivation face multiple health and social challenges, and this high level of need has impacts on the work of health practitioners working in such areas. All families in the UK with children under five years have access to health visiting services, and health visitors have a key role in mitigating the effects of deprivation by addressing health needs through evidence based practice. This paper reports the first stage of a project in Tower Hamlets, London, an area of significant deprivation, which aims to develop an evidence-based toolkit to support health visitors in their practice with families. The first stage used a modified Delphi process to identify the priority health needs of families in the area between June and July 2012. The three-stage Delphi process involved 25 people: four health visitors, four other members of the health visiting service, and 17 representatives of other services working with families. A focus group event was followed by a second event where individuals completed a questionnaire ranking the 27 priorities identified in the first event. The consultation process concluded with participants completing a second questionnaire, by email, confirming or changing their prioritisation of the topics. PMID:24151552

  1. Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis

    PubMed Central

    2010-01-01

    Background Computer-based morphometry can minimize subjectivity in the assessment of liver fibrosis. An image processing program was developed with Delphi for the quantification of fibrosis in liver tissue samples stained with Sirius Red. Bile duct ligated and sham operated wild type C57BL/6 mice served as a model of time-dependent induction of liver fibrosis. Formation of fibrosis was determined with the developed software at day 0, 3, 7, 10, 14, 20, 30 and 60. The results were compared to a semi-quantitative scoring system. Results Quantitative accumulation of collagen fibres was observed from day 3 to day 14, with a slight further increase thereafter. During ongoing fibrogenesis, there was a significant elevation of alanine aminotransferase (ALT), aspartate transaminase (AST) and bilirubin. The results from our computer-based morphometric analysis were highly correlated with the results that were obtained in a standardized pathology semi-quantitative scoring system (R 2 = 0.89, n = 38). Conclusions Using our Delphi-based image analysing software, the morphometric assessment of fibrosis is as precise as semi-quantitative scoring by an experienced pathologist. This program can be a valuable tool in any kind of experimental or clinical setting for standardized quantitative assessment of fibrosis. PMID:20565730

  2. Developing a Competency-based Curriculum in Basic and Clinical Pharmacology--A Delphi Study among Physicians.

    PubMed

    Midlöv, Patrik; Höglund, Peter; Eriksson, Tommy; Diehl, Annika; Edgren, Gudrun

    2015-12-01

    A new curriculum is planned for the medical school at Lund University, Sweden. Pharmacology, in a broad sense, has been identified as a subject that needs to be strengthened based on needs in the healthcare system. The aim was to identify the competencies in basic and clinical pharmacology that a newly qualified physician needs. Using a modified three-round Delphi technique, 31 physicians were invited to list necessary competencies (round 1). After content analysis, these panel members classified the list by importance on two occasions (rounds 2 and 3) using a 4-point scale (4 = necessary, 3 = desirable, 2 = useful, 1 = not necessary). Competencies with the highest ranks based on necessity were retained. Thirty physicians accepted the invitation and 25 (83%) of them completed all three rounds. Round 1 resulted in 258 suggestions, which were subsequently reduced to 95 competencies. Of these 95 competencies, 40 were considered necessary by at least 75% of the panel members. The degree of consensus increased between round 2 and round 3. Using a modified Delphi technique, we identified 40 competencies that could be transferred to learning outcomes for a new curriculum in basic and clinical pharmacology at medical school.

  3. A Delphi Study to Detect Deficiencies and Propose Actions in Real Life Treatment of Neovascular Age-Related Macular Degeneration

    PubMed Central

    García-Layana, Alfredo; Arias, Luis; Figueroa, Marta S.; Araiz, Javier; Ruiz-Moreno, José María; García-Arumí, José; Gómez-Ulla, Francisco; López-Gálvez, María Isabel; Cabrera-López, Francisco; García-Campos, José Manuel; Monés, Jordi; Cervera, Enrique; Armadá, Felix; Piñero-Bustamante, Antonio; Serrano-Garcia, Miguel Angel

    2014-01-01

    Purpose. Spanish retina specialists were surveyed in order to propose actions to decrease deficiencies in real-life neovascular age macular degeneration treatment (nv-AMD). Methods. One hundred experts, members of the Spanish Vitreoretinal Society (SERV), were invited to complete an online survey of 52 statements about nv-AMD management with a modified Delphi methodology. Four rounds were performed using a 5-point Linkert scale. Recommendations were developed after analyzing the differences between the results and the SERV guidelines recommendations. Results. Eighty-seven specialists completed all the Delphi rounds. Once major potential deficiencies in real-life nv-AMD treatment were identified, 15 recommendations were developed with a high level of agreement. Consensus statements to reduce the burden of the disease included the use of treat and extend regimen and to reduce the amount of diagnostic tests during the loading phase and training technical staff to perform these tests and reduce the time between relapse detection and reinjection, as well as establishing patient referral protocols to outside general ophthalmology clinics. Conclusion. The level of agreement with the final recommendations for nv-AMD treatment among Spanish retinal specialist was high indicating that some actions could be applied in order to reduce the deficiencies in real-life nv-AMD treatment. PMID:25587438

  4. Say it in Croatian--Croatian translation of the EGPRN definition of multimorbidity using a Delphi consensus technique.

    PubMed

    Lazić, Đurđica Kašuba; Le Reste, Jean-Yves; Murgić, Lucija; Petriček, Goranka; Katič, Milica; Ožvačić-Adžić, Zlata; Nekič, Venija Cerovečki; Nabbe, Patrice; Hasanagić, Melida; Assenova, Radost; Lygidakis, Charilaos; Linger, Heidrun; Doerr, Crista; Czachowski, Slawomir; Sowinskas, Agnieszka; Le Floch, Bernard; Munoz, Miquel; Argyriadou, Stella; Van Marwijk, Harm; Lietardl, Claire; Van Royen, Paul

    2014-09-01

    Patients coming to their family physician (FP) usually have more than one condition or problem. Multimorbidity as well as dealing with it, is challenging for FPs even as a mere concept. The World Health Organization (WHO) has simply defined multimorbidity as two or more chronic conditions existing in one patient. However, this definition seems inadequate for a holistic approach to patient care within Family Medicine. Using systematic literature review the European General Practitioners Research Network (EGPRN) developed a comprehensive definition of multimorbidity. For practical and wider use, this definition had to be translated into other languages, including Croatian. Here presented is the Croatian translation of this comprehensive definition using a Delphi consensus procedure for forward/backward translation. 23 expert FPs fluent in English were asked to rank the translation from 1 (absolutely disagreeable) to 9 (fully agreeable) and to explain each score under 7. It was previously defined that consensus would be reached when 70% of the scores are above 6. Finally, a backward translation from Croatian into English was undertaken and approved by the authors of the English definition. Consensus was reached after the first Delphi round with 100% of the scores above 6; therefore the Croatian translation was immediately accepted. The authors of the English definition accepted the backward translation. A comprehensive definition of multimorbidity is now available in English and Croatian, as well as other European languages which will surely make further implications for clinicians, researchers or policy makers.

  5. Identifying components of advanced-level clinical nutrition practice: a Delphi study.

    PubMed

    Brody, Rebecca A; Byham-Gray, Laura; Touger-Decker, Riva; Passannante, Marian R; O'Sullivan Maillet, Julie

    2012-06-01

    The dietetics profession lacks a comprehensive definition of advanced-level practice. Using a three-round Delphi study with mailed surveys, expert consensus on four dimensions of advanced-level practice that define advanced practice registered dietitians (RDs) in clinical nutrition was explored. Purposive sampling identified 117 RDs who met advanced-level practice criteria. In round 1, experts rated the essentiality of statements on a 7-point ordinal scale and generated open-ended practice activity statements regarding the following four dimensions of advanced-level practice: professional knowledge, abilities and skills, approaches to practice, roles and relationships, and practice behaviors. Median ratings of 1.0 to 3.0 were defined as essential, 4.0 was neutral, and 5.0 to 7.0 were nonessential. In rounds 2 and 3, experts re-rated statements not reaching consensus by evaluating their previous responses, group median rating, and comments. Consensus was reached when the interquartile range of responses to a statement was ≤2.0. Eighty-five experts enrolled (72.6%); 76 (89.4%) completed all rounds. In total, 233 statements were rated, with 100% achieving consensus; 211 (90.6%) were essential to advanced practice RD clinical practice. Having a master's degree; completing an advanced practice residency; research coursework; and advanced continuing education were essential, as were having 8 years of experience; clinical nutrition knowledge/expertise; specialization; participation in research activities; and skills in technology and communication. Highly essential approaches to practice were systematic yet adaptable and used critical thinking and intuition and highly essential values encompassed professional growth and service to patients. Roles emphasized patient care and leadership. Essential practice activities within the nutrition care process included provision of complex patient-centered nutrition care using application of advanced knowledge/expertise and

  6. Patient transitions relevant to individuals requiring ongoing ventilatory assistance: A Delphi study

    PubMed Central

    Rose, Louise; Fowler, Robert A; Goldstein, Roger; Katz, Sherri; Leasa, David; Pedersen, Cheryl; McKim, Douglas

    2014-01-01

    BACKGROUND: Various terms, including ‘prolonged mechanical ventilation’ (PMV) and ‘long-term mechanical ventilation’ (LTMV), are used interchangeably to distinguish patient cohorts requiring ventilation, making comparisons and timing of clinical decision making problematic. OBJECTIVE: To develop expert, consensus-based criteria associated with care transitions to distinguish cohorts of ventilated patients. METHODS: A four-round (R), web-based Delphi study with consensus defined as >70% was performed. In R1, participants listed, using free text, criteria perceived to should and should not define seven transitions. Transitions comprised: T1 – acute ventilation to PMV; T2 – PMV to LTMV; T3 – PMV or LTMV to acute ventilation (reverse transition); T4 – institutional to community care; T5 – no ventilation to requiring LTMV; T6 – pediatric to adult LTMV; and T7 – active treatment to end-of-life care. Subsequent Rs sought consensus. RESULTS: Experts from intensive care (n=14), long-term care (n=14) and home ventilation (n=10), representing a variety of professional groups and geographical areas, completed all Rs. Consensus was reached on 14 of 20 statements defining T1 and 21 of 25 for T2. ‘Physiological stability’ had the highest consensus (97% and 100%, respectively). ‘Duration of ventilation’ did not achieve consensus. Consensus was achieved on 13 of 18 statements for T3 and 23 of 25 statements for T4. T4 statements reaching 100% consensus included: ‘informed choice’, ‘patient stability’, ‘informal caregiver support’, ‘caregiver knowledge’, ‘environment modification’, ‘supportive network’ and ‘access to interprofessional care’. Consensus was achieved for 15 of 17 T5, 16 of 20 T6 and 21 of 24 T7 items. CONCLUSION: Criteria to consider during key care transitions for ventilator-assisted individuals were identified. Such information will assist in furthering the consistency of clinical care plans, research trials

  7. What Caused the UK's Largest Common Dolphin (Delphinus delphis) Mass Stranding Event?

    PubMed Central

    Jepson, Paul D.; Deaville, Robert; Acevedo-Whitehouse, Karina; Barnett, James; Brownlow, Andrew; Brownell Jr., Robert L.; Clare, Frances C.; Davison, Nick; Law, Robin J.; Loveridge, Jan; Macgregor, Shaheed K.; Morris, Steven; Murphy, Sinéad; Penrose, Rod; Perkins, Matthew W.; Pinn, Eunice; Seibel, Henrike; Siebert, Ursula; Sierra, Eva; Simpson, Victor; Tasker, Mark L.; Tregenza, Nick; Cunningham, Andrew A.; Fernández, Antonio

    2013-01-01

    On 9 June 2008, the UK's largest mass stranding event (MSE) of short-beaked common dolphins (Delphinus delphis) occurred in Falmouth Bay, Cornwall. At least 26 dolphins died, and a similar number was refloated/herded back to sea. On necropsy, all dolphins were in good nutritive status with empty stomachs and no evidence of known infectious disease or acute physical injury. Auditory tissues were grossly normal (26/26) but had microscopic haemorrhages (5/5) and mild otitis media (1/5) in the freshest cases. Five lactating adult dolphins, one immature male, and one immature female tested were free of harmful algal toxins and had low chemical pollutant levels. Pathological evidence of mud/seawater inhalation (11/26), local tide cycle, and the relative lack of renal myoglobinuria (26/26) suggested MSE onset on a rising tide between 06∶30 and 08∶21 hrs (9 June). Potential causes excluded or considered highly unlikely included infectious disease, gas/fat embolism, boat strike, by-catch, predator attack, foraging unusually close to shore, chemical or algal toxin exposure, abnormal weather/climatic conditions, and high-intensity acoustic inputs from seismic airgun arrays or natural sources (e.g., earthquakes). International naval exercises did occur in close proximity to the MSE with the most intense part of the exercises (including mid-frequency sonars) occurring four days before the MSE and resuming with helicopter exercises on the morning of the MSE. The MSE may therefore have been a “two-stage process” where a group of normally pelagic dolphins entered Falmouth Bay and, after 3–4 days in/around the Bay, a second acoustic/disturbance event occurred causing them to strand en masse. This spatial and temporal association with the MSE, previous associations between naval activities and cetacean MSEs, and an absence of other identifiable factors known to cause cetacean MSEs, indicates naval activity to be the most probable cause of the Falmouth Bay MSE. PMID

  8. Important challenges for coordination and inter-municipal cooperation in health care services: a Delphi study

    PubMed Central

    2013-01-01

    Background Demographical changes have stimulated a coordination reform in the Norwegian health care sector, creating new working practices and extending coordination within and between primary and hospital care, increasing the need for inter-municipal cooperation (IMC). This study aimed to identify challenges to coordination and IMC in the Norwegian health care sector as a basis for further theorizing and managerial advice in this growing area of research and practice. Methods A Delphi study of consensus development was used. Experts in coordination and IMC in health care services were selected by the healthcare manager or the councillor in their respective municipalities. In the first round, an expert panel received open-ended questions addressing possible challenges, and their answers were categorized and consolidated as the basis for further validation in the second round. The expert panel members were then asked to point out important statements in the third round, before the most important statements ranked by a majority of the members were rated again in the fourth round, including the option to explain the ratings. The same procedure was used in round five, with the exception that the expert panel members could view the consolidated results of their previous rankings as the basis for a new and final rating. The statements reaching consensus in round five were abstracted and themed. Results Nineteen experts consented to participate. Nine experts (47%) completed all of the five rounds. Eight statements concerning coordination reached consensus, resulting in four themes covering these challenges: different culture, uneven balance of power, lack of the possibility to communicate electronically, and demanding tasks in relation to resources. Three statements regarding challenges to IMC reached consensus, resulting in following themes: coopetition, complex leadership, and resistance to change. Conclusions This study identified several important challenges for

  9. Helping someone with problem drinking: Mental health first aid guidelines - a Delphi expert consensus study

    PubMed Central

    2009-01-01

    Background Alcohol is a leading risk factor for avoidable disease burden. Research suggests that a drinker's social network can play an integral role in addressing hazardous (i.e., high-risk) or problem drinking. Often however, social networks do not have adequate mental health literacy (i.e., knowledge about mental health problems, like problem drinking, or how to treat them). This is a concern as the response that a drinker receives from their social network can have a substantial impact on their willingness to seek help. This paper describes the development of mental health first aid guidelines that inform community members on how to help someone who may have, or may be developing, a drinking problem (i.e., alcohol abuse or dependence). Methods A systematic review of the research and lay literature was conducted to develop a 285-item survey containing strategies on how to help someone who may have, or may be developing, a drinking problem. Two panels of experts (consumers/carers and clinicians) individually rated survey items, using a Delphi process. Surveys were completed online or via postal mail. Participants were 99 consumers, carers and clinicians with experience or expertise in problem drinking from Australia, Canada, Ireland, New Zealand, the United Kingdom, and the United States. Items that reached consensus on importance were retained and written into guidelines. Results The overall response rate across all three rounds was 68.7% (67.6% consumers/carers, 69.2% clinicians), with 184 first aid strategies rated as essential or important by ≥80% of panel members. The endorsed guidelines provide guidance on how to: recognize problem drinking; approach someone if there is concern about their drinking; support the person to change their drinking; respond if they are unwilling to change their drinking; facilitate professional help seeking and respond if professional help is refused; and manage an alcohol-related medical emergency. Conclusion The guidelines

  10. A cognitive perspective on health systems integration: results of a Canadian Delphi study

    PubMed Central

    2014-01-01

    Background Ongoing challenges to healthcare integration point toward the need to move beyond structural and process issues. While we know what needs to be done to achieve integrated care, there is little that informs us as to how. We need to understand how diverse organizations and professionals develop shared knowledge and beliefs – that is, we need to generate knowledge about normative integration. We present a cognitive perspective on integration, based on shared mental model theory, that may enhance our understanding and ability to measure and influence normative integration. The aim of this paper is to validate and improve the Mental Models of Integrated Care (MMIC) Framework, which outlines important knowledge and beliefs whose convergence or divergence across stakeholder groups may influence inter-professional and inter-organizational relations. Methods We used a two-stage web-based modified Delphi process to test the MMIC Framework against expert opinion using a random sample of participants from Canada’s National Symposium on Integrated Care. Respondents were asked to rate the framework’s clarity, comprehensiveness, usefulness, and importance using seven-point ordinal scales. Spaces for open comments were provided. Descriptive statistics were used to describe the structured responses, while open comments were coded and categorized using thematic analysis. The Kruskall-Wallis test was used to examine cross-group agreement by level of integration experience, current workplace, and current role. Results In the first round, 90 individuals responded (52% response rate), representing a wide range of professional roles and organization types from across the continuum of care. In the second round, 68 individuals responded (75.6% response rate). The quantitative and qualitative feedback from experts was used to revise the framework. The re-named “Integration Mindsets Framework” consists of a Strategy Mental Model and a Relationships Mental Model

  11. Expert Delphi survey on research and development into drugs for neglected diseases

    PubMed Central

    2011-01-01

    Background Tropical infectious diseases are called neglected, because they are, inter alia, characterized by an R&D deficit. A similar deficit exists for rare (orphan) diseases which neither promise a sufficient return on R&D investment. To encourage the development of treatments for rare diseases, orphan drug acts were created which contain financial and non-financial incentives for the pharmaceutical industry. Similar instruments aimed exclusively at neglected diseases do not yet exist. Proposals for a regulatory approach to promote R&D for neglected diseases include the application of selected orphan drug incentives, or the implementation of a Medical Research and Development Treaty (MRDT) with national funding obligations for medical R&D. We compiled and analyzed experts' opinions on causes for the treatment deficit for neglected diseases and on desirable and feasible measures to promote neglected disease R&D. Hereby, the focus was on mechanisms contained in orphan drug regulations and in the Medical Research and Development Treaty draft (Discussion draft 4, 2005). Lastly, we solicited experts' opinions on the desirability and feasibility of a regulatory instrument to foster R&D for neglected diseases. Methods An international online-Delphi survey was conducted with 117 (first round) and 56 (second round) experts of different professional backgrounds and professional affiliations who formulated and ranked causes and solutions related to the treatment deficit for neglected diseases. Results In both rounds of survey, the majority of the participating experts (88.4% first round, 86.8% second round) advocated the development of a regulatory instrument to promote R&D for neglected diseases. Most experts (77.9% first round, 79.3% second round) also considered this to be a feasible option. With the exception of market exclusivity, which was viewed critically, key provisions contained in orphan drug regulations were judged favorably also for neglected diseases. A

  12. Developing Canadian oncology education goals and objectives for medical students: a national modified Delphi study

    PubMed Central

    Tam, Vincent C.; Ingledew, Paris-Ann; Berry, Scott; Verma, Sunil; Giuliani, Meredith E.

    2016-01-01

    Background: Studies have shown that there is a deficiency in focused oncology teaching during medical school in Canada. This study aimed to develop oncology education goals and objectives for medical students through consensus of oncology educators from across Canada. Methods: In 2014 we created a comprehensive list of oncology education objectives using existing resources. Experts in oncology education and undergraduate medical education from all 17 Canadian medical schools were invited to participate in a 3-round modified Delphi process. In round 1, the participants scored the objectives on a 9-point Likert scale according to the degree to which they agreed an objective should be taught to medical students. Objectives with a mean score of 7.0 or greater were retained, those with a mean score of 1.0-3.9 were excluded, and those with a mean score of 4.0-6.9 were discussed at a round 2 Web meeting. In round 3, the participants voted on inclusion and exclusion of the round 2 objectives. Results: Thirty-four (92%) of the 37 invited oncology educators, representing 14 medical schools, participated in the study. They included oncologists, family physicians, members of undergraduate medical education curriculum committees and a psychologist. Of the 214 objectives reviewed in round 1, 146 received a mean score of 7.0 or greater, and 68 were scored 4.0-6.9; no objective received a mean score below 4.0. Nine new objectives were suggested. The main themes of participants' comments were to minimize the number of objectives and to aim objectives at the knowledge level required for family physicians. In round 2, the participants were able to combine 28 of the objectives with other existing objectives. In round 3, 7 of the 49 objectives received consensus of at least 75% for inclusion. The final Canadian Oncology Goals and Objectives for Medical Students contained 10 goals and 153 objectives. Interpretation: Through a systematic process, we created a comprehensive, consensus

  13. Using the Delphi Method for Selecting Effective Rehabilitation Practices for Case Study Research: Methods, Challenges, and Solutions and Implications for Future Research

    ERIC Educational Resources Information Center

    Fleming, Allison R.; Boeltzig-Brown, Heike; Foley, Susan M.

    2015-01-01

    Purpose: We describe a modified Delphi method used to select effective state vocational rehabilitation agency practices to prioritize rehabilitation services for individuals with most significant disabilities within the context of Order of Selection, an area where there is little known and published. Specifically, we describe how we applied the…

  14. A Delphi Study to Understand Relational Bonds in Supervision and Their Effect on Rehabilitation Counselor Disclosure in the Public Rehabilitation Program

    ERIC Educational Resources Information Center

    Magnuson, Lori Anne

    2012-01-01

    The scholarly literature surrounding counselor supervision suggests that relational bonds built on liking, trusting, and caring between supervisors and counselors positively impact counselor willingness to disclose practice errors and ethical issues in supervision. This Delphi study explored the opinions of expert public rehabilitation supervisors…

  15. A Modified Delphi Study to Identify the Significant Works Pertaining to the Understanding of Reading Comprehension and Content Analysis of the Identified Works

    ERIC Educational Resources Information Center

    Zunker, Norma D.

    2009-01-01

    The first part of this study explored the significant works pertaining to the understanding of reading comprehension using a Modified Delphi Method. A panel of reading comprehension experts in the field of reading identified 20 works they considered to be significant to the understanding of reading comprehension. The panel of experts additionally…

  16. A Modified Delphi to Identify the Significant Works Pertaining to the Understanding of Reading Comprehension and Content Analysis of the Identified Works

    ERIC Educational Resources Information Center

    Zunker, Norma D.; Pearce, Daniel L.

    2012-01-01

    The first part of this study explored the significant works pertaining to the understanding of reading comprehension using a Modified Delphi Method. A panel of reading comprehension experts identified 19 works they considered to be significant to the understanding of reading comprehension. The panel of experts identified the reasons they…

  17. The Desired Learning Outcomes of School-Based Nutrition/Physical Activity Health Education: A Health Literacy Constructed Delphi Survey of Finnish Experts

    ERIC Educational Resources Information Center

    Ormshaw, Michael James; Kokko, Sami Petteri; Villberg, Jari; Kannas, Lasse

    2016-01-01

    Purpose: The purpose of this paper is to utilise the collective opinion of a group of Finnish experts to identify the most important learning outcomes of secondary-level school-based health education, in the specific domains of physical activity and nutrition. Design/ Methodology/ Approach: The study uses a Delphi survey technique to collect the…

  18. On L3 Acquisition and Phonological Permeability: A New Test Case for Debates on the Mental Representation of Non-Native Phonological Systems

    ERIC Educational Resources Information Center

    Amaro, Jennifer Cabrelli; Rothman, Jason

    2010-01-01

    The goal of this article is to make an epistemological and theoretical contribution to the nascent field of third language (L3) acquisition and show how examining L3 development can offer a unique view into longstanding debates within L2 acquisition theory. We offer the Phonological Permeability Hypothesis (PPH), which maintains that examining the…

  19. English L3 Learning in a Multilingual Context: The Role of Parental Education and L2 Exposure within the Living Community

    ERIC Educational Resources Information Center

    De Angelis, Gessica

    2015-01-01

    The present study examines two factors in relation to English L3 proficiency development and school performance in a third language: (a) parental education and (b) second language exposure within the living community. Participants (n?=?50) are Italian L1 students with German L2 and English L3. All students (eighth grade, 14 years of age) were…

  20. The Use of the L1 and the L2 in French L3: Examining Cross-Linguistic Lexemes in Multilingual Learners' Oral Production

    ERIC Educational Resources Information Center

    Lindqvist, Christina

    2009-01-01

    This study investigates to what degree, and in what manner, the L1 and L2(s) influence spoken French L3. The analysis is divided in two parts. The first examines the cross-linguistic lexemes of 30 Swedish learners, divided into three groups according to previous exposure to French. The results show that proficiency in the L3 is crucial: the least…

  1. An Exploratory Study on the Role of L1 Chinese and L2 English in the Cross-Linguistic Influence in L3 French

    ERIC Educational Resources Information Center

    Cai, Hansong; Cai, Luna Jing

    2015-01-01

    This research investigates cross-linguistic influence in the comprehension of L3 French past tense. A close examination was made on the L1 (Chinese) and L2 (English) transfer patterns among 20 English majors in their early acquisition of L3 French passé compose (PC). Data were collected through introspective think-aloud protocol in a comprehension…

  2. Functional binding of a vertebrate hormone, L-3,5,3'-triiodothyronine (T3), on insect follicle cell membranes.

    PubMed

    Kim, Y; Davari, E D; Sevala, V; Davey, K G

    1999-10-01

    A vertebrate hormone, L-3,5,3'-triiodothyronine (T3), induces volume reduction in the follicle cells of Locusta migratoria and Rhodnius prolixus. The effect of T3 on locust follicle cells is inhibited by ouabain and by antibodies raised against a membrane binding protein for juvenile hormone (JH). [125I]-T3 binds to membrane preparations of vitellogenic follicles in a specific and saturable fashion, with a KD in the low nanomolar range. T3 and JH III exhibited equivalent abilities to compete for the T3 binding site. These findings strongly suggest that T3 and JH act via the same receptor in follicle cells. PMID:10528413

  3. Genomic characterization of Defluviitoga tunisiensis L3, a key hydrolytic bacterium in a thermophilic biogas plant and its abundance as determined by metagenome fragment recruitment.

    PubMed

    Maus, Irena; Cibis, Katharina Gabriela; Bremges, Andreas; Stolze, Yvonne; Wibberg, Daniel; Tomazetto, Geizecler; Blom, Jochen; Sczyrba, Alexander; König, Helmut; Pühler, Alfred; Schlüter, Andreas

    2016-08-20

    The genome sequence of Defluviitoga tunisiensis L3 originating from a thermophilic biogas-production plant was established and recently published as Genome Announcement by our group. The circular chromosome of D. tunisiensis L3 has a size of 2,053,097bp and a mean GC content of 31.38%. To analyze the D. tunisiensis L3 genome sequence in more detail, a phylogenetic analysis of completely sequenced Thermotogae strains based on shared core genes was performed. It appeared that Petrotoga mobilis DSM 10674(T), originally isolated from a North Sea oil-production well, is the closest relative of D. tunisiensis L3. Comparative genome analyses of P. mobilis DSM 10674(T) and D. tunisiensis L3 showed moderate similarities regarding occurrence of orthologous genes. Both genomes share a common set of 1351 core genes. Reconstruction of metabolic pathways important for the biogas production process revealed that the D. tunisiensis L3 genome encodes a large set of genes predicted to facilitate utilization of a variety of complex polysaccharides including cellulose, chitin and xylan. Ethanol, acetate, hydrogen (H2) and carbon dioxide (CO2) were found as possible end-products of the fermentation process. The latter three metabolites are considered to represent substrates for methanogenic Archaea, the key organisms in the final step of the anaerobic digestion process. To determine the degree of relatedness between D. tunisiensis L3 and dominant biogas community members within the thermophilic biogas-production plant, metagenome sequences obtained from the corresponding microbial community were mapped onto the L3 genome sequence. This fragment recruitment revealed that the D. tunisiensis L3 genome is almost completely covered with metagenome sequences featuring high matching accuracy. This result indicates that strains highly related or even identical to the reference strain D. tunisiensis L3 play a dominant role within the community of the thermophilic biogas-production plant. PMID

  4. Genomic characterization of Defluviitoga tunisiensis L3, a key hydrolytic bacterium in a thermophilic biogas plant and its abundance as determined by metagenome fragment recruitment.

    PubMed

    Maus, Irena; Cibis, Katharina Gabriela; Bremges, Andreas; Stolze, Yvonne; Wibberg, Daniel; Tomazetto, Geizecler; Blom, Jochen; Sczyrba, Alexander; König, Helmut; Pühler, Alfred; Schlüter, Andreas

    2016-08-20

    The genome sequence of Defluviitoga tunisiensis L3 originating from a thermophilic biogas-production plant was established and recently published as Genome Announcement by our group. The circular chromosome of D. tunisiensis L3 has a size of 2,053,097bp and a mean GC content of 31.38%. To analyze the D. tunisiensis L3 genome sequence in more detail, a phylogenetic analysis of completely sequenced Thermotogae strains based on shared core genes was performed. It appeared that Petrotoga mobilis DSM 10674(T), originally isolated from a North Sea oil-production well, is the closest relative of D. tunisiensis L3. Comparative genome analyses of P. mobilis DSM 10674(T) and D. tunisiensis L3 showed moderate similarities regarding occurrence of orthologous genes. Both genomes share a common set of 1351 core genes. Reconstruction of metabolic pathways important for the biogas production process revealed that the D. tunisiensis L3 genome encodes a large set of genes predicted to facilitate utilization of a variety of complex polysaccharides including cellulose, chitin and xylan. Ethanol, acetate, hydrogen (H2) and carbon dioxide (CO2) were found as possible end-products of the fermentation process. The latter three metabolites are considered to represent substrates for methanogenic Archaea, the key organisms in the final step of the anaerobic digestion process. To determine the degree of relatedness between D. tunisiensis L3 and dominant biogas community members within the thermophilic biogas-production plant, metagenome sequences obtained from the corresponding microbial community were mapped onto the L3 genome sequence. This fragment recruitment revealed that the D. tunisiensis L3 genome is almost completely covered with metagenome sequences featuring high matching accuracy. This result indicates that strains highly related or even identical to the reference strain D. tunisiensis L3 play a dominant role within the community of the thermophilic biogas-production plant.

  5. Stakeholder involvement in establishing a milk quality sub-index in dairy cow breeding goals: a Delphi approach.

    PubMed

    Henchion, M; McCarthy, M; Resconi, V C; Berry, D P; McParland, S

    2016-05-01

    The relative weighting on traits within breeding goals are generally determined by bio-economic models or profit functions. While such methods have generally delivered profitability gains to producers, and are being expanded to consider non-market values, current approaches generally do not consider the numerous and diverse stakeholders that affect, or are affected, by such tools. Based on principles of respondent anonymity, iteration, controlled feedback and statistical aggregation of feedback, a Delphi study was undertaken to gauge stakeholder opinion of the importance of detailed milk quality traits within an overall dairy breeding goal for profit, with the aim of assessing its suitability as a complementary, participatory approach to defining breeding goals. The questionnaires used over two survey rounds asked stakeholders: (a) their opinion on incorporating an explicit sub-index for milk quality into a national breeding goal; (b) the importance they would assign to a pre-determined list of milk quality traits and (c) the (relative) weighting they would give such a milk quality sub-index. Results from the survey highlighted a good degree of consensus among stakeholders on the issues raised. Similarly, revelation of the underlying assumptions and knowledge used by stakeholders to make their judgements illustrated their ability to consider a range of perspectives when evaluating traits, and to reconsider their answers based on the responses and rationales given by others, which demonstrated social learning. Finally, while the relative importance assigned by stakeholders in the Delphi survey (4% to 10%) and the results of calculations based on selection index theory of the relative emphasis that should be placed on milk quality to halt any deterioration (16%) are broadly in line, the difference indicates the benefit of considering more than one approach to determining breeding goals. This study thus illustrates the role of the Delphi technique, as a complementary

  6. Stakeholder involvement in establishing a milk quality sub-index in dairy cow breeding goals: a Delphi approach.

    PubMed

    Henchion, M; McCarthy, M; Resconi, V C; Berry, D P; McParland, S

    2016-05-01

    The relative weighting on traits within breeding goals are generally determined by bio-economic models or profit functions. While such methods have generally delivered profitability gains to producers, and are being expanded to consider non-market values, current approaches generally do not consider the numerous and diverse stakeholders that affect, or are affected, by such tools. Based on principles of respondent anonymity, iteration, controlled feedback and statistical aggregation of feedback, a Delphi study was undertaken to gauge stakeholder opinion of the importance of detailed milk quality traits within an overall dairy breeding goal for profit, with the aim of assessing its suitability as a complementary, participatory approach to defining breeding goals. The questionnaires used over two survey rounds asked stakeholders: (a) their opinion on incorporating an explicit sub-index for milk quality into a national breeding goal; (b) the importance they would assign to a pre-determined list of milk quality traits and (c) the (relative) weighting they would give such a milk quality sub-index. Results from the survey highlighted a good degree of consensus among stakeholders on the issues raised. Similarly, revelation of the underlying assumptions and knowledge used by stakeholders to make their judgements illustrated their ability to consider a range of perspectives when evaluating traits, and to reconsider their answers based on the responses and rationales given by others, which demonstrated social learning. Finally, while the relative importance assigned by stakeholders in the Delphi survey (4% to 10%) and the results of calculations based on selection index theory of the relative emphasis that should be placed on milk quality to halt any deterioration (16%) are broadly in line, the difference indicates the benefit of considering more than one approach to determining breeding goals. This study thus illustrates the role of the Delphi technique, as a complementary

  7. The DELPHI expert process of the German umbrella project AUGE as basis for recommendations to CO2 storage in Germany

    NASA Astrophysics Data System (ADS)

    Pilz, Peter; Schoebel, Birgit; Liebscher, Axel

    2016-04-01

    Within the GEOTECHNOLOGIEN funding scheme for geological CO2 storage by the Federal Ministry of Education and Research (BMBF) in Germany 33 projects (135 subprojects) have been funded with a total budget of 58 Mio € (excluding industry funds) from 2005 to 2014. In 2012, the German parliament passed the transposition of the EU CCS Directive 2009/31/EG into the national "Carbon Dioxide Storage Law" (KSpG). Annex 1 of the KSpG provides a description of criteria for the characterization and assessment of a potential CO2 storage site. Annex 2 describes the expected monitoring system of a CO2 storage site. The criteria given in the appendices are of general nature, which reflects (1) that the CO2 storage technology is still being developed and (2) that site specific aspects needs to be considered. In 2012 an umbrella project called AUGE has been launched in order to compile and summarize the results of the GEOTECHNOLOGIEN projects to underpin the two Annexes scientifically. By integration of the individual project results AUGE aims at derive recommendations for the review and implementation of the KSpG. The recommendations shall be drafted based on a common ground of science, public authorities and industry. Therefore, the AUGE project includes a Delphi expert process as an essential part. It is realized in cooperation with the company COMPARE Consulting, Göppingen. The implementation of the Delphi-Process is organized in three steps: • After the technical preparation of a standardized questionnaire (2014/2015) it was sent to 129 experts from science, industry and public authorities in Germany. After a few weeks of consideration time, 40 persons (30 %) had decided to participate actively in this inquiry. • Following the results of the first interrogation campaign, the second survey campaign started at the end of 2015. The same list of questions was used, complemented with the results of the first inquiry campaign. The intention is reduce the variance of the

  8. Use of a Web-based Delphi for identifying critical components of a professional science master's program in biotechnology

    NASA Astrophysics Data System (ADS)

    Kantz, Jeannine Wells

    The primary purpose of this research was to develop a model for a professional science master's program combining biotechnology and business. The objectives were to identify stakeholder preferences for various dimensions of a professional science master's program combining biotechnology and business and to identify differences in priorities between subgroups. A secondary purpose was to examine user preferences between Web-based and traditional methods of conducting a Delphi study and the panelist's impressions of its usefulness for program development. Prior to the first round, demographic data were collected on panelists regarding their gender, age, years experience in their current field, position title and education levels. Round 1 started with eight open-ended questions designed to investigate (a) learning objectives, (b) internships, (c) thesis vs. non-thesis degrees, (d) program focus (e) possible entry level positions, (f) roles for the industry advisory board, (g) recommended hours of hands-on experience and (h) other issues of importance. The final round ended with three questions to assess the panelists' perception of the usefulness of the Delphi for program development in higher education. Twenty-four panelists started Round 1 and participation in subsequent rounds varied from 17 in Round 2 to 11 in Round 4. Education level varied and included all levels of education in science and business. Issues emerged early in the study regarding development of different program tracks and the program goals, which were clarified in subsequent rounds. Significant differences occurred between industry and academic subgroups for two tracks, six skills designated for tracks, method of evaluating the internship, and entry-level positions appropriate for new graduates. When analyzed by level of confidence (high confidence vs. low confidence), significant differences occurred for (a) the number of semesters of hands-on experience students should have upon graduation, (b

  9. SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers.

    PubMed

    Angelov, Borislav; Angelova, Angelina; Mutafchieva, Rada; Lesieur, Sylviane; Vainio, Ulla; Garamus, Vasil M; Jensen, Grethe V; Pedersen, Jan Skov

    2011-02-28

    The encapsulation and release of peptides, proteins, nucleic acids, and drugs in nanostructured lipid carriers depend on the type of the self-assembled liquid-crystalline organization and the structural dimensions of the aqueous and membraneous compartments, which can be tuned by the multicomponent composition of the systems. In this work, small-angle X-ray scattering (SAXS) investigation is performed on the 'melting' transition of the bicontinuous double diamond cubic phase, formed by pure glycerol monooleate (MO), upon progressive inclusion of varying fractions of pharmaceutical-grade glycerol monooleate (GO) in the hydrated system. The self-assembled MO/GO mixtures are found to form diamond (Pn3m) inverted cubic, inverted hexagonal (H(II)), and sponge (L(3)) phases at ambient temperature in excess of aqueous medium without heat treatment. Mixing of the inverted-cubic-phase-forming MO and the sponge-phase-forming GO components, in equivalent proportions (50/50 w/w), yields an inverted hexagonal (H(II)) phase nanostructured carrier. Scattering models are applied for fitting of the experimental SAXS patterns and identification of the structural changes in the aqueous and lipid bilayer subcompartments. The possibility of transforming, at ambient temperature (20 °C), the bicontinuous cubic nanostructures into inverted hexagonal (H(II)) or sponge (L(3)) mesophases may facilitate novel biomedical applications of the investigated liquid crystalline self-assemblies. PMID:21079857

  10. Single mutations introduced in the essential ribosomal proteins L3 and S10 cause a sporulation defect in Bacillus subtilis.

    PubMed

    Akanuma, Genki; Suzuki, Shota; Yano, Koichi; Nanamiya, Hideaki; Natori, Yousuke; Namba, Eri; Watanabe, Kazuya; Tagami, Kazumi; Takeda, Takuya; Iizuka, Yuka; Kobayashi, Ako; Ishizuka, Morio; Yoshikawa, Hirofumi; Kawamura, Fujio

    2013-01-01

    We introduced single mutations into the rplC and rpsJ genes, which encode the essential ribosomal proteins L3 (RplC) and S10 (RpsJ), respectively, and are located in the S10 gene cluster of the gram-positive, endospore-forming bacterium Bacillus subtilis, and examined whether these mutations affected their growth rate, sporulation, competence development and 70S ribosome formation. Mutant cells harboring the G52D mutation in the L3 ribosomal protein, which is located at the peptidyl transferase center of 50S, accumulated 30S subunit at 45°C, probably due to a defect in 50S formation, and exhibited a reduction in the sporulation frequency at high temperature. On the other hand, mutant cells harboring the H56R mutation in the S10 protein, which is located near the aminoacyl-tRNA site of 30S, showed severe growth defect and deficiency in spore formation, and also exhibited significant delay in competence development.

  11. Prolonged response to calling songs by the L3 auditory interneuron in female crickets (Acheta domesticus): intracellular evaluation.

    PubMed

    Navia, Benjamin; Stout, John; Atkins, Gordon

    2003-03-01

    The L3 auditory interneuron in female Acheta domesticus, produces two different responses to the male calling song: an immediate response and a prolonged response. The prolonged response exhibited spiking activity and a correlated prolonged depolarization, both of which are clearly seen in intracellular recordings. The morphology revealed by intracellular staining was clearly the L3 neuron. The amplitude of the prolonged depolarization associated with the prolonged response increased with increases in sound intensity, resulting in increased spiking rates. Both depolarization and sound presentation increased the spiking rate and the slope of pre-potentials (thus leading to spiking threshold more quickly). Injecting hyperpolarizing current had the expected opposite effect. The effects of positive current injection and sound presentation were additive, resulting in spiking rates that were approximately double the rates in response to sound alone. Short postsynaptic potentials (PSPs), whose duration ranged from 15-60 ms, which may lead to action potentials were also observed in all recordings and summated with the prolonged depolarization, increasing the probability of spiking.

  12. New [Mo(eta3-allyl)(CO)2L3]+ complexes with monodentate or tridentate nitrogen-donor ligands.

    PubMed

    Pérez, Julio; Morales, Dolores; Nieto, Sonia; Riera, Lucía; Riera, Víctor; Miguel, Daniel

    2005-03-01

    Cationic complexes [Mo(eta(3)-allyl)(CO)2L3]+ (L3 = either nitrogen-donor tridentate ligand or three monodentate ligands) were prepared in high yield and under mild conditions using as precursors either the triflato complex [Mo(eta(3)-allyl)(OTf)(CO)2(NCMe)2] or the combination of the chloro complex [Mo(eta(3)-allyl)Cl(CO)2(NCMe)2] and the salt NaBAr'(4)(Ar'= 3,5-bis(trifluoromethyl)phenyl). The tridentate ligands employed were 2,2':6',2'-terpyridine (terpy) and cis,cis-1,3,5-cyclohexanetriamine (CHTA), whereas the monodentate ligands imidazole (im) and 3,5-dimethylpyrazole (dmpz) were chosen. In order to stabilize the labile intermediates, an excess of acetonitrile was used in most of the syntheses. However, the pyrazole complex was prepared through a nitrile-free route to avoid reactions at the coordinated nitrile. The solid state structures of [Mo(eta(3)-methallyl)(CO)2(terpy)]OTf (2), [Mo(eta(3)-methallyl)(CO)2(CHTA)]BAr'4 (3), [Mo(eta(3)-methallyl)(CO)2(NCMe)3]BAr'4 (4), [Mo(eta(3)-allyl)(CO)2(im)3]OTf (5) and [Mo(eta(3)-allyl)(CO)2(dmpz)3]BAr'4 (6) were determined by means of single-crystal X-ray diffraction. PMID:15726140

  13. New patterns of the growing L3 vertebra and its 3 ossification centers in human fetuses – a CT, digital, and statistical study

    PubMed Central

    Szpinda, Michał; Baumgart, Mariusz; Szpinda, Anna; WoŸniak, Alina; Mila-Kierzenkowska, Celestyna

    2013-01-01

    Background This study describes reference data for L3 vertebra and its 3 ossification centers at varying gestational ages. Material/Methods Using CT, digital-image analysis and statistics, the growth of L3 vertebra and its 3 ossification centers in 55 spontaneously aborted human fetuses aged 17–30 weeks was examined. Results Neither sex nor right-left significant differences were found. The height and transverse and sagittal diameters of the L3 vertebral body increased logarithmically. Its cross-sectional area followed linearly, whereas its volume increased parabolically. The transverse and sagittal diameters of the ossification center of the L3 vertebral body varied logarithmically, but its cross-sectional area and volume grew linearly. The ossification center-to-vertebral body volume ratio gradually declined with age. The neural ossification centers increased logarithmically in length and width, and proportionately in cross-sectional area and volume. Conclusions With no sex differences, the growth dynamics of the L3 vertebral body follow logarithmically in height, sagittal and transverse diameters, linearly (in cross-sectional area), and parabolically (in volume). The growth dynamics of the 3 ossification centers of the L3 vertebra follow logarithmically in transverse and sagittal diameters, and linearly (in cross-sectional area and volume). The age-specific reference intervals of the L3 vertebra and its 3 ossification centers present the normative values of clinical importance in the diagnosis of congenital spinal defects. PMID:23778313

  14. An expert-based approach to forest road network planning by combining Delphi and spatial multi-criteria evaluation.

    PubMed

    Hayati, Elyas; Majnounian, Baris; Abdi, Ehsan; Sessions, John; Makhdoum, Majid

    2013-02-01

    Changes in forest landscapes resulting from road construction have increased remarkably in the last few years. On the other hand, the sustainable management of forest resources can only be achieved through a well-organized road network. In order to minimize the environmental impacts of forest roads, forest road managers must design the road network efficiently and environmentally as well. Efficient planning methodologies can assist forest road managers in considering the technical, economic, and environmental factors that affect forest road planning. This paper describes a three-stage methodology using the Delphi method for selecting the important criteria, the Analytic Hierarchy Process for obtaining the relative importance of the criteria, and finally, a spatial multi-criteria evaluation in a geographic information system (GIS) environment for identifying the lowest-impact road network alternative. Results of the Delphi method revealed that ground slope, lithology, distance from stream network, distance from faults, landslide susceptibility, erosion susceptibility, geology, and soil texture are the most important criteria for forest road planning in the study area. The suitability map for road planning was then obtained by combining the fuzzy map layers of these criteria with respect to their weights. Nine road network alternatives were designed using PEGGER, an ArcView GIS extension, and finally, their values were extracted from the suitability map. Results showed that the methodology was useful for identifying road that met environmental and cost considerations. Based on this work, we suggest future work in forest road planning using multi-criteria evaluation and decision making be considered in other regions and that the road planning criteria identified in this study may be useful.

  15. Quality care, public perception and quick-fix service management: a Delphi study on stressors of hospital doctors in Ireland

    PubMed Central

    Hayes, Blanaid; Fitzgerald, Deirdre; Doherty, Sally; Walsh, Gillian

    2015-01-01

    Objectives To identify and rank the most significant workplace stressors to which consultants and trainees are exposed within the publicly funded health sector in Ireland. Design Following a preliminary semistructured telephone interview, a Delphi technique with 3 rounds of reiterative questionnaires was used to obtain consensus. Conducted in Spring 2014, doctors were purposively selected by their college faculty or specialty training body. Setting Consultants and higher specialist trainees who were engaged at a collegiate level with their faculty or professional training body. All were employed in the Irish publicly funded health sector by the Health Services Executive. Participants 49 doctors: 30 consultants (13 male, 17 female) and 19 trainees (7 male, 12 female). Consultants and trainees were from a wide range of hospital specialties including anaesthetics, radiology and psychiatry. Results Consultants are most concerned with the quality of healthcare management and its impact on service. They are also concerned about the quality of care they provide. They feel undervalued within the negative sociocultural environment that they work. Trainees also feel undervalued with an uncertain future and they also perceive their sociocultural environment as negative. They echo concerns regarding the quality of care they provide. They struggle with the interface between career demands and personal life. Conclusions This Delphi study sought to explore the working life of doctors in Irish hospitals at a time when resources are scarce. It identified both common and distinct concerns regarding sources of stress for 2 groups of doctors. Its identification of key stressors should guide managers and clinicians towards solutions for improving the quality of patient care and the health of care providers. PMID:26700286

  16. How do stakeholder groups vary in a Delphi technique about primary mental health care and what factors influence their ratings?

    PubMed Central

    Campbell, S; Shield, T; Rogers, A; Gask, L

    2004-01-01

    Background: While mental health is a core part of primary care, there are few validated quality measures and little relevant internationally published research. Consensus panel methods are a useful means of developing quality measures where evidence is sparse and/or opinions are diverse. However, little is known about the dynamics of consensus techniques and the factors that influence the judgements and ratings of panels and individual panellists. Objectives: (1) To describe differences in panel ratings on the quality of primary mental health care services by patient, carer, professional and managerial panels within a Delphi procedure; and (2) to explore why different panels and panellists rate quality indicators of primary mental health care differently. Design: Two round postal Delphi technique and exploratory semi-structured interviews. Participants: 115 panellists across 11 panels. Eleven panellists were subsequently interviewed. Results: 87 of 334 indicators (26%) were rated face valid by all 11 panels. There was little disagreement within panel ratings but significant differences between panels. The GP panel rated the least number of indicators valid (n = 138, 41%) and carers the most (n = 304, 91%). The way in which panellists interpreted and conceptualised the indicators and their definition of quality of mental health care affected the way in which participants made their ratings. Conclusions: Stakeholders in primary mental health care have diverse views of quality of care and these differences translate into how they rate quality indicators. Exploratory interviews suggest that ratings are influenced by past experience, expectations, definitions of quality of care, and perceived power relationships between stakeholders. PMID:15576704

  17. When providers and community leaders define health priorities: the results of a Delphi survey in the canton of Geneva.

    PubMed

    Schopper, D; Ammon, C; Ronchi, A; Rougemont, A

    2000-08-01

    The Delphi method was used to determine the health priorities in one Swiss canton. The opinion of various groups concerned, either as health professionals or as representatives of the general population, was gathered to identify the health determinants and health problems perceived as most important, to clarify the reasons for these choices, and to recommend interventions to be undertaken in order to improve the situation in the identified priority areas. Five panels, including health professionals as well as selected leaders of community groups with no direct involvement in health, were given the opportunity to reply to two rounds of questionnaires. There was a high convergence of opinion on health determinants and problems to be given priority between panels and between the first and second round. Priorities identified are mainly physical problems (cardiovascular disease, respiratory and breast cancer, AIDS, injuries due to road accidents, chronic back pain), psychosocial disorders (depression, suicide, violence in the family, stress), and problems of substance abuse (alcohol and tobacco). Unemployment and social isolation were chosen because of their perceived impact on health. Very few interventions were proposed in the medical technical or research areas. This may be due partly to the fact that good quality care is widely available and accessible in Geneva, whereas preventive programmes have not received enough attention in the past. Through the identified priorities and the proposed activities, a new vision of health emerges which gives more importance to psychosocial problems and the social environment. In this context, health promotion is seen as essential, acknowledging that sustained change in individual behaviours can only occur if the social and cultural context is taken into consideration. In conclusion, the results of this survey show that the Delphi method is a useful tool to reach consensus on health priorities and corresponding activities among a

  18. Drivers for the effective management of HIV and AIDS in the South African construction industry--a Delphi study.

    PubMed

    Harinarain, Nishani; Haupt, Theo Conrad

    2014-09-01

    Different industries manage the threats presented by HIV and AIDS in different ways. The construction industry is particularly vulnerable to the pandemic because of its large unskilled labour force, high labour turnover and the migratory nature of the workforce. The study reported on in this paper, the first of its kind in the South African construction industry, aimed to identify the important drivers needed for the effective management of HIV and AIDS and to understand their impact on the construction industry. The aim was achieved in two stages. The first stage involved an extensive literature review to determine the factors that drive corporate response in the management of HIV and AIDS in the South African construction sector. Six drivers, namely legal requirements, social pressures, business costs, voluntary regulation, visibility of the disease, and individuals within companies with a total of 87 items were identified. An iterative Delphi technique with a panel of experts was used to validate the factors identified in the literature review and formed the second stage of this research. The Delphi method was used as it provided a systematic approach to achieve consensus on the six drivers for effective management of HIV and AIDS management in the construction industry. An expert panel responded to three iterations of questionnaires to achieve consensus. The experts reached consensus on 56 items categorised under the 6 drivers. This study found that the legal driver was considered most important but only second in terms of impact. The second most important driver was the visibility of the disease and was regarded as the driver with the highest impact. Internal agents ranked third in terms of importance and impact. This study can be used for further research to assist the construction industry in helping fight HIV and AIDS.

  19. The U. S. transportation sector in the year 2030: results of a two-part Delphi survey.

    SciTech Connect

    Morrison, G.; Stephens, T.S.

    2011-10-11

    A two-part Delphi Survey was given to transportation experts attending the Asilomar Conference on Transportation and Energy in August, 2011. The survey asked respondents about trends in the US transportation sector in 2030. Topics included: alternative vehicles, high speed rail construction, rail freight transportation, average vehicle miles traveled, truck versus passenger car shares, vehicle fuel economy, and biofuels in different modes. The survey consisted of two rounds -- both asked the same set of seven questions. In the first round, respondents were given a short introductory paragraph about the topic and asked to use their own judgment in their responses. In the second round, the respondents were asked the same questions, but were also given results from the first round as guidance. The survey was sponsored by Argonne National Lab (ANL), the National Renewable Energy Lab (NREL), and implemented by University of California at Davis, Institute of Transportation Studies. The survey was part of the larger Transportation Energy Futures (TEF) project run by the Department of Energy, Office of Energy Efficiency and Renewable Energy. Of the 206 invitation letters sent, 94 answered all questions in the first round (105 answered at least one question), and 23 of those answered all questions in the second round. 10 of the 23 second round responses were at a discussion section at Asilomar, while the remaining were online. Means and standard deviations of responses from Round One and Two are given in Table 1 below. One main purpose of Delphi surveys is to reduce the variance in opinions through successive rounds of questioning. As shown in Table 1, the standard deviations of 25 of the 30 individual sub-questions decreased between Round One and Round Two, but the decrease was slight in most cases.

  20. Mental Health First Aid guidelines for helping a suicidal person: a Delphi consensus study in the Philippines

    PubMed Central

    2010-01-01

    Background This study aimed to develop guidelines for how a member of the Filipino public should provide mental health first aid to a person who is suicidal. Methods The guidelines were produced by developing a questionnaire containing possible first aid actions and asking an expert panel of 34 Filipino mental health clinicians to rate whether each action should be included in the guidelines. The content of the questionnaire was based on a systematic search of the relevant evidence and claims made by authors of consumer and carer guides and websites. The panel members were asked to complete the questionnaire by web survey. Three rounds of the rating were carried and, at the end of each round, items that reached the consensus criterion were selected for inclusion in the guidelines. During the first round, panel members were also asked to suggest any additional actions that were not covered in the original questionnaire (to include items that are relevant to local cultural circumstances, values, and social norms). Responses to these open-ended questions were used to generate new items. Results The output from the Delphi process was a set of agreed upon action statements. The Delphi process started with 138 statements, 48 new items were written based on suggestions from panel members and, of these 186 items, 102 met the consensus criterion. These statements were used to develop the guidelines appended to this paper. The guidelines are currently being translated into local languages. Conclusions There are a number of actions that are considered to be useful for members of the public when they encounter someone who is experiencing suicidal thoughts or engaging in suicidal behaviour. Although the guidelines are designed for members of the public, they may also be helpful to non-mental health professionals working in health and welfare settings. PMID:21167076

  1. An expert-based approach to forest road network planning by combining Delphi and spatial multi-criteria evaluation.

    PubMed

    Hayati, Elyas; Majnounian, Baris; Abdi, Ehsan; Sessions, John; Makhdoum, Majid

    2013-02-01

    Changes in forest landscapes resulting from road construction have increased remarkably in the last few years. On the other hand, the sustainable management of forest resources can only be achieved through a well-organized road network. In order to minimize the environmental impacts of forest roads, forest road managers must design the road network efficiently and environmentally as well. Efficient planning methodologies can assist forest road managers in considering the technical, economic, and environmental factors that affect forest road planning. This paper describes a three-stage methodology using the Delphi method for selecting the important criteria, the Analytic Hierarchy Process for obtaining the relative importance of the criteria, and finally, a spatial multi-criteria evaluation in a geographic information system (GIS) environment for identifying the lowest-impact road network alternative. Results of the Delphi method revealed that ground slope, lithology, distance from stream network, distance from faults, landslide susceptibility, erosion susceptibility, geology, and soil texture are the most important criteria for forest road planning in the study area. The suitability map for road planning was then obtained by combining the fuzzy map layers of these criteria with respect to their weights. Nine road network alternatives were designed using PEGGER, an ArcView GIS extension, and finally, their values were extracted from the suitability map. Results showed that the methodology was useful for identifying road that met environmental and cost considerations. Based on this work, we suggest future work in forest road planning using multi-criteria evaluation and decision making be considered in other regions and that the road planning criteria identified in this study may be useful. PMID:22565600

  2. Application of Delphi-AHP methods to select the priorities of WEEE for recycling in a waste management decision-making tool.

    PubMed

    Kim, Mincheol; Jang, Yong-Chul; Lee, Seunguk

    2013-10-15

    The management of waste electrical and electronic equipment (WEEE) or electronic waste (e-waste) has become a major issue of concern for solid waste communities due to the large volumes of waste being generated from the consumption of modern electrical and electronic products. In 2003, Korea introduced the extended producer responsibility (EPR) system to reduce the amount of electronic products to be disposed and to promote resource recovery from WEEE. The EPR currently regulates a total of 10 electrical and electronic products. This paper presents the results of the application of the Delphi method and analytical hierarchy process (AHP) modeling to the WEEE management tool in the policy-making process. Specifically, this paper focuses on the application of the Delphi-AHP technique to determine the WEEE priority to be included in the EPR system. Appropriate evaluation criteria were derived using the Delphi method to assess the potential selection and priority among electrical and electronic products that will be regulated by the EPR system. Quantitative weightings from the AHP model were calculated to identify the priorities of electrical and electronic products to be potentially regulated. After applying all the criteria using the AHP model, the results indicate that the top 10 target recycling products for the expansion of the WEEE list were found to be vacuum cleaners, electric fans, rice cookers, large freezers, microwave ovens, water purifiers, air purifiers, humidifiers, dryers, and telephones in order from the first to last. The proposed Delphi-AHP method can offer a more efficient means of selecting WEEE than subjective assessment methods that are often based on professional judgment or limited available data. By providing WEEE items to be regulated, the proposed Delphi-AHP method can eliminate uncertainty and subjective assessment and enable WEEE management policy-makers to identify the priority of potential WEEE. More generally, the work performed in this

  3. Application of Delphi-AHP methods to select the priorities of WEEE for recycling in a waste management decision-making tool.

    PubMed

    Kim, Mincheol; Jang, Yong-Chul; Lee, Seunguk

    2013-10-15

    The management of waste electrical and electronic equipment (WEEE) or electronic waste (e-waste) has become a major issue of concern for solid waste communities due to the large volumes of waste being generated from the consumption of modern electrical and electronic products. In 2003, Korea introduced the extended producer responsibility (EPR) system to reduce the amount of electronic products to be disposed and to promote resource recovery from WEEE. The EPR currently regulates a total of 10 electrical and electronic products. This paper presents the results of the application of the Delphi method and analytical hierarchy process (AHP) modeling to the WEEE management tool in the policy-making process. Specifically, this paper focuses on the application of the Delphi-AHP technique to determine the WEEE priority to be included in the EPR system. Appropriate evaluation criteria were derived using the Delphi method to assess the potential selection and priority among electrical and electronic products that will be regulated by the EPR system. Quantitative weightings from the AHP model were calculated to identify the priorities of electrical and electronic products to be potentially regulated. After applying all the criteria using the AHP model, the results indicate that the top 10 target recycling products for the expansion of the WEEE list were found to be vacuum cleaners, electric fans, rice cookers, large freezers, microwave ovens, water purifiers, air purifiers, humidifiers, dryers, and telephones in order from the first to last. The proposed Delphi-AHP method can offer a more efficient means of selecting WEEE than subjective assessment methods that are often based on professional judgment or limited available data. By providing WEEE items to be regulated, the proposed Delphi-AHP method can eliminate uncertainty and subjective assessment and enable WEEE management policy-makers to identify the priority of potential WEEE. More generally, the work performed in this

  4. Biosynthesis of riboflavin. Studies on the mechanism of L-3,4-dihydroxy-2-butanone 4-phosphate synthase.

    PubMed

    Volk, R; Bacher, A

    1991-11-01

    The riboflavin precursor, L-3,4-dihydroxy-2-butanone 4-phosphate, is formed from D-ribulose 5-phosphate by a single 24-kDa enzyme. Studies with various specifically 13C-labeled D-ribulose 5-phosphates as substrate showed that the carbon atoms 1-3 of the enzyme product correspond to carbon atoms 1-3 of the substrate, whereas C-4 of the product stems from C-5 of the substrate. Carbon atom 4 of the substrate is released as formate together with the hydrogen atom attached to it. The skeletal rearrangement which leads to the loss of C-4 and the direct linkage between C-3 and C-5 of the substrate is an intramolecular reaction. The hydrogen atom at C-3 of the enzyme product is introduced from solvent water. A reaction mechanism which is in agreement with all experimental data is proposed. PMID:1939111

  5. Gallium nitride L3 photonic crystal cavities with an average quality factor of 16 900 in the near infrared

    SciTech Connect

    Vico Triviño, Noelia; Carlin, Jean-François; Butté, Raphaël; Grandjean, Nicolas; Minkov, Momchil Savona, Vincenzo; Urbinati, Giulia; Galli, Matteo

    2014-12-08

    Photonic crystal point-defect cavities were fabricated in a GaN free-standing photonic crystal slab. The cavities are based on the popular L3 design, which was optimized using an automated process based on a genetic algorithm, in order to maximize the quality factor. Optical characterization of several individual cavity replicas resulted in an average unloaded quality factor Q = 16 900 at the resonant wavelength λ∼1.3 μm, with a maximal measured Q value of 22 500. The statistics of both the quality factor and the resonant wavelength are well explained by first-principles simulations including fabrication disorder and background optical absorption.

  6. Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration

    PubMed Central

    Peloquin, John M.; Yoder, Jonathon H.; Jacobs, Nathan T.; Moon, Sung M.; Wright, Alexander C.; Vresilovic, Edward J.; Elliott, Dawn M.

    2014-01-01

    Intervertebral disc mechanics are affected by both disc shape and disc degeneration, which in turn each affect the other; disc mechanics additionally have a role in the etiology of disc degeneration. Finite element analysis (FEA) is a favored tool to investigate these relationships, but limited data for intervertebral disc 3D shape has forced the use of simplified or single-subject geometries, with the effect of inter-individual shape variation investigated only in specialized studies. Similarly, most data on disc shape variation with degeneration is based on 2D mid-sagittal images, which incompletely define 3D shape changes. Therefore, the objective of this study was to quantify inter-individual disc shape variation in 3D, classify this variation into independently-occurring modes using a statistical shape model, and identify correlations between disc shape and degeneration. Three-dimensional disc shapes were obtained from MRI of 13 human male cadaver L3L4 discs. An average disc shape and four major modes of shape variation (representing 90% of the variance) were identified. The first mode represented disc axial area and was significantly correlated to degeneration (R2 = 0.44), indicating larger axial area in degenerate discs. Disc height variation occurred in three distinct modes, each also involving non-height variation. The statistical shape model provides an average L3L4 disc shape for FEA that is fully defined in 3D, and makes it convenient to generate a set of shapes with which to represent aggregate inter-individual variation. Degeneration grade-specific shapes can also be generated. To facilitate application, the model is included in this paper’s supplemental content. PMID:24792581

  7. Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration.

    PubMed

    Peloquin, John M; Yoder, Jonathon H; Jacobs, Nathan T; Moon, Sung M; Wright, Alexander C; Vresilovic, Edward J; Elliott, Dawn M

    2014-07-18

    Intervertebral disc mechanics are affected by both disc shape and disc degeneration, which in turn each affect the other; disc mechanics additionally have a role in the etiology of disc degeneration. Finite element analysis (FEA) is a favored tool to investigate these relationships, but limited data for intervertebral disc 3D shape has forced the use of simplified or single-subject geometries, with the effect of inter-individual shape variation investigated only in specialized studies. Similarly, most data on disc shape variation with degeneration is based on 2D mid-sagittal images, which incompletely define 3D shape changes. Therefore, the objective of this study was to quantify inter-individual disc shape variation in 3D, classify this variation into independently-occurring modes using a statistical shape model, and identify correlations between disc shape and degeneration. Three-dimensional disc shapes were obtained from MRI of 13 human male cadaver L3L4 discs. An average disc shape and four major modes of shape variation (representing 90% of the variance) were identified. The first mode represented disc axial area and was significantly correlated to degeneration (R(2)=0.44), indicating larger axial area in degenerate discs. Disc height variation occurred in three distinct modes, each also involving non-height variation. The statistical shape model provides an average L3L4 disc shape for FEA that is fully defined in 3D, and makes it convenient to generate a set of shapes with which to represent aggregate inter-individual variation. Degeneration grade-specific shapes can also be generated. To facilitate application, the model is included in this paper׳s supplemental content. PMID:24792581

  8. Using X-ray microscopy and Hg L3 XANES to study Hg binding in the rhizosphere of Spartina cordgrass.

    PubMed

    Patty, Cynthia; Barnett, Brandy; Mooney, Bridget; Kahn, Amanda; Levy, Silvio; Liu, Yijin; Pianetta, Piero; Andrews, Joy C

    2009-10-01

    San Francisco Bay has been contaminated historically by mercury from mine tailings as well as contemporary industrial sources. Native Spartina foliosa and non-native S. alterniflora-hybrid cordgrasses are dominant florae within the SF Bay estuary environment. Understanding mercury uptake and transformations in these plants will help to characterize the significance of their roles in mercury biogeochemical cycling in the estuarine environment. Methylated mercury can be biomagnified up the food web, resulting in levels in sport fish up to 1 million times greater than in surrounding waters and resulting in advisories to limit fish intake. Understanding the uptake and methylation of mercury in the plant rhizosphere can yield insight into ways to manage mercury contamination. The transmission X-ray microscope on beamline 6-2 at the Stanford Synchrotron Radiation Lightsource (SSRL) was used to obtain absorption contrast images and 3D tomography of Spartina foliosa roots that were exposed to 1 ppm Hg (as HgCl2) hydroponically for 1 week. Absorption contrast images of micrometer-sized roots from S. foliosa revealed dark particles, and dark channels within the root, due to Hg absorption. 3D tomography showed that the particles are on the root surface, and slices from the tomographic reconstruction revealed that the particles are hollow, consistent with microorganisms with a thin layer of Hg on the surface. Hg L3 XANES of ground-up plant roots and Hg L3 micro-XANES from microprobe analysis of micrometer-sized roots (60-120 microm in size) revealed three main types of speciation in both Spartina species: Hg-S ligation in a form similar to Hg(II) cysteine, Hg-S bonding as in cinnabar and metacinnabar, and methylmercury-carboxyl bonding in a form similar to methylmercury acetate. These results are interpreted within the context of obtaining a "snapshot" of mercury methylation in progress.

  9. Using X-ray microscopy and Hg L3 XANES to study Hg binding in the rhizosphere of Spartina cordgrass.

    PubMed

    Patty, Cynthia; Barnett, Brandy; Mooney, Bridget; Kahn, Amanda; Levy, Silvio; Liu, Yijin; Pianetta, Piero; Andrews, Joy C

    2009-10-01

    San Francisco Bay has been contaminated historically by mercury from mine tailings as well as contemporary industrial sources. Native Spartina foliosa and non-native S. alterniflora-hybrid cordgrasses are dominant florae within the SF Bay estuary environment. Understanding mercury uptake and transformations in these plants will help to characterize the significance of their roles in mercury biogeochemical cycling in the estuarine environment. Methylated mercury can be biomagnified up the food web, resulting in levels in sport fish up to 1 million times greater than in surrounding waters and resulting in advisories to limit fish intake. Understanding the uptake and methylation of mercury in the plant rhizosphere can yield insight into ways to manage mercury contamination. The transmission X-ray microscope on beamline 6-2 at the Stanford Synchrotron Radiation Lightsource (SSRL) was used to obtain absorption contrast images and 3D tomography of Spartina foliosa roots that were exposed to 1 ppm Hg (as HgCl2) hydroponically for 1 week. Absorption contrast images of micrometer-sized roots from S. foliosa revealed dark particles, and dark channels within the root, due to Hg absorption. 3D tomography showed that the particles are on the root surface, and slices from the tomographic reconstruction revealed that the particles are hollow, consistent with microorganisms with a thin layer of Hg on the surface. Hg L3 XANES of ground-up plant roots and Hg L3 micro-XANES from microprobe analysis of micrometer-sized roots (60-120 microm in size) revealed three main types of speciation in both Spartina species: Hg-S ligation in a form similar to Hg(II) cysteine, Hg-S bonding as in cinnabar and metacinnabar, and methylmercury-carboxyl bonding in a form similar to methylmercury acetate. These results are interpreted within the context of obtaining a "snapshot" of mercury methylation in progress. PMID:19848152

  10. Simulating Ru L3-Edge X-ray Absorption Spectroscopy with Time-Dependent Density Functional Theory: Model Complexes and Electron Localization in Mixed-Valence Metal Dimers

    SciTech Connect

    Kuiken, Benjamin E. Van; Valiev, Marat; Daifuku, Stephanie L.; Bannan, Caitlin; Strader, Matthew L.; Cho, Hana; Huse, Nils; Schoenlein, Robert W.; Govind, Niranjan; Khalil, Munira

    2013-04-26

    Ruthenium L3-edge X-ray absorption (XA) spectroscopy probes unoccupied 4d orbitals of the metal atom and is increasingly being used to investigate the local electronic structure in ground and excited electronic states of Ru complexes. The simultaneous development of computational tools for simulating Ru L3-edge spectra is crucial for interpreting the spectral features at a molecular level. This study demonstrates that time-dependent density functional theory (TDDFT) is a viable and predictive tool for simulating ruthenium L3-edge XA spectroscopy. We systematically investigate the effects of exchange correlation functional and implicit and explicit solvent interactions on a series of RuII and RuIII complexes in their ground and electronic excited states. The TDDFT simulations reproduce all of the experimentally observed features in Ru L3-edge XA spectra within the experimental resolution (0.4 eV). Our simulations identify ligand-specific charge transfer features in complicated Ru L3-edge spectra of [Ru(CN)6]4- and RuII polypyridyl complexes illustrating the advantage of using TDDFT in complex systems. We conclude that the B3LYP functional most accurately predicts the transition energies of charge transfer features in these systems. We use our TDDFT approach to simulate experimental Ru L3-edge XA spectra of transition metal mixed-valence dimers of the form [(NC)5MII-CN-RuIII(NH3)5] (where M = Fe or Ru) dissolved in water. Our study determines the spectral signatures of electron delocalization in Ru L3-edge XA spectra. We find that the inclusion of explicit solvent molecules is necessary for reproducing the spectral features and the experimentally determined valencies in these mixed-valence complexes. This study validates the use of TDDFT for simulating Ru 2p excitations using popular quantum chemistry codes and providing a powerful interpretive tool for equilibrium and ultrafast Ru L3-edge XA spectroscopy.

  11. On the Typological Economy of Syntactic Transfer: Word Order and Relative Clause High/Low Attachment Preference in L3 Brazilian Portuguese

    ERIC Educational Resources Information Center

    Rothman, Jason

    2010-01-01

    One central question in the formal linguistic study of adult multilingual morphosyntax (i.e., L3/Ln acquisition) involves determining the role(s) the L1 and/or the L2 play(s) at the L3 initial state (e.g., Bardel & Falk, Second Language Research 23: 459-484, 2007; Falk & Bardel, Second Language Research: forthcoming; Flynn et al., The…

  12. In vivo effects of monoclonal anti-L3T4 antibody on immune responsiveness of mice infected with Schistosoma mansoni. Reduction of irradiated cercariae-induced resistance

    SciTech Connect

    Kelly, E.A.; Colley, D.G.

    1988-04-15

    Mice can be partially protected against challenge infections of Schistosoma mansoni cercariae by either single or multiple exposure to irradiated cercariae (x-cerc). The participation of L3T4+ lymphocytes on this resistance phenomenon was evaluated by selectively depleting this cell population through in vivo administration of mAb anti-L3T4 at three different times in relationship to the challenge infections. Treatment with anti-L3T4 before challenge such that depletion was effective during the time of cercarial skin penetration and dermal/s.c. residence significantly reduced the level of resistance induced by x-cerc sensitization. When treatment was delayed until after challenge, depletion of L3T4+ cells coincided with either the lung or post-lung/liver phases of schistosomular migration, and normal levels of x-cerc-induced resistance were induced. In contrast to once-immunized mice, mice hyperimmunized by five exposures to x-cerc and then depleted of L3T4+ cells at the time of challenge still expressed resistance to the challenge. These data suggest that when mice are sensitized only once with x-cerc the challenge infection provides a necessary immunologic boost which requires L3T4+ cells for effective expression of resistance. The requirement for this anamnestic effect by the challenge infection can be circumvented by hyperimmunization. Evaluation of the immune response of one-time sensitized or hyperimmunized mice demonstrated that cellular Ag-specific proliferative responses and mitogen-induced lymphokine production were abrogated after any of the various in vivo regimens of anti-L3T4 antibody. In contrast, immunoblot analysis of humoral responsiveness revealed a correlation between the expression of resistance and the ability of sera from immunized and anti-L3T4 treated mice to recognize a 75-kDa parasite antigenic component.

  13. Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

    PubMed Central

    Nakagawa, Yoshimi; Oikawa, Fusaka; Mizuno, Seiya; Ohno, Hiroshi; Yagishita, Yuka; Satoh, Aoi; Osaki, Yoshinori; Takei, Kenta; Kikuchi, Takuya; Han, Song-iee; Matsuzaka, Takashi; Iwasaki, Hitoshi; Kobayashi, Kazuto; Yatoh, Shigeru; Yahagi, Naoya; Isaka, Masaaki; Suzuki, Hiroaki; Sone, Hirohito; Takahashi, Satoru; Yamada, Nobuhiro; Shimano, Hitoshi

    2016-01-01

    cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy homeostasis. Tissue-specific CREB3L3 knockout mice have not been generated till date. To our knowledge, this is the first study using the one-step CRISPR/Cas9 system to generate CREB3L3 floxed mice and subsequently obtain liver- and small intestine-specific Creb3l3 knockout (LKO and IKO, respectively) mice. While LKO mice as well as global KO mice developed hypertriglyceridemia, LKO mice exhibited hypercholesterolemia in contrast to hypocholesterolemia in global KO mice. LKO mice demonstrated up-regulation of hepatic Srebf2 and its corresponding target genes. No phenotypic differences were observed between IKO and floxed mice. Severe liver injury was observed in LKO mice fed a methionine-choline deficient diet, a model for non-alcoholic steatohepatitis. These results provide new evidence regarding the hepatic CREB3L3 role in plasma triglyceride metabolism and hepatic and intestinal CREB3L3 contributions to cholesterol metabolism. PMID:27291420

  14. Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP.

    PubMed

    Esposito, Davide; Crescenzi, Elvira; Sagar, Vinay; Loreni, Fabrizio; Russo, Annapina; Russo, Giulia

    2014-11-30

    Recent evidence showed that a variety of DNA damaging agents including 5-FU and L-OHP impairs ribosomal biogenesis activating a ribosomal stress pathway. Here, we demonstrate that in lung and colon cancer cell lines devoid of p53, the efficacy of 5-FU and L-OHP chemotherapy depends on rpL3 status. Specifically, we demonstrate that ribosomal stress induced by 5-FU and L-OHP is associated to up-regulation of rpL3 and its accumulation as ribosome-free form. We show that rpL3 participates in the cell response to chemotherapy acting as a critical regulator of cell cycle, apoptosis and DNA repair, by modulating p21 expression. Moreover, we demonstrate that rpL3 is able to control DNA repair also independently from p21 status of cell. It is noteworthy that silencing of rpL3 abolishes the cytotoxic effects of 5-FU and L-OH indicating that the loss of rpL3 makes chemotherapy drugs ineffective. Taking together our results shed light on 5-FU and L-OHP mechanism of action and contribute to more effective clinical use of these drugs in cancer therapy. PMID:25473889

  15. Development of mental health first aid guidelines for Aboriginal and Torres Strait Islander people experiencing problems with substance use: a Delphi study

    PubMed Central

    2010-01-01

    Background Problems with substance use are common in some Aboriginal communities. Although problems with substance use are associated with significant mortality and morbidity, many people who experience them do not seek help. Training in mental health first aid has been shown to be effective in increasing knowledge of symptoms and behaviours associated with seeking help. The current study aimed to develop culturally appropriate guidelines for providing mental health first aid to an Aboriginal or Torres Strait Islander person who is experiencing problem drinking or problem drug use (e.g. abuse or dependence). Methods Twenty-eight Aboriginal health experts participated in two independent Delphi studies (n = 22 problem drinking study, n = 21 problem drug use; 15 participated in both). Panellists were presented with statements about possible first aid actions via online questionnaires and were encouraged to suggest additional actions not covered by the content. Statements were accepted for inclusion in the guidelines if they were endorsed by ≥ 90% of panellists as either 'Essential' or 'Important'. At the end of the two Delphi studies, participants were asked to give feedback on the value of the project and their participation experience. Results From a total of 735 statements presented over two studies, 429 were endorsed (223 problem drinking, 206 problem drug use). Statements were grouped into sections based on common themes (n = 7 problem drinking, n = 8 problem drug use), then written into guideline documents. Participants evaluated the Delphi method employed, and the guidelines developed, as useful and appropriate for Aboriginal and Torres Strait Islander people. Conclusions Aboriginal health experts were able to reach consensus about culturally appropriate first aid for problems with substance use. Many first aid actions endorsed in the current studies were not endorsed in previous international Delphi studies, conducted on problem drinking and problem drug use

  16. A Delphi Technology Foresight Study: Mapping Social Construction of Scientific Evidence on Metagenomics Tests for Water Safety.

    PubMed

    Birko, Stanislav; Dove, Edward S; Özdemir, Vural

    2015-01-01

    Access to clean water is a grand challenge in the 21st century. Water safety testing for pathogens currently depends on surrogate measures such as fecal indicator bacteria (e.g., E. coli). Metagenomics concerns high-throughput, culture-independent, unbiased shotgun sequencing of DNA from environmental samples that might transform water safety by detecting waterborne pathogens directly instead of their surrogates. Yet emerging innovations such as metagenomics are often fiercely contested. Innovations are subject to shaping/construction not only by technology but also social systems/values in which they are embedded, such as experts' attitudes towards new scientific evidence. We conducted a classic three-round Delphi survey, comprised of 107 questions. A multidisciplinary expert panel (n = 24) representing the continuum of discovery scientists and policymakers evaluated the emergence of metagenomics tests. To the best of our knowledge, we report here the first Delphi foresight study of experts' attitudes on (1) the top 10 priority evidentiary criteria for adoption of metagenomics tests for water safety, (2) the specific issues critical to governance of metagenomics innovation trajectory where there is consensus or dissensus among experts, (3) the anticipated time lapse from discovery to practice of metagenomics tests, and (4) the role and timing of public engagement in development of metagenomics tests. The ability of a test to distinguish between harmful and benign waterborne organisms, analytical/clinical sensitivity, and reproducibility were the top three evidentiary criteria for adoption of metagenomics. Experts agree that metagenomic testing will provide novel information but there is dissensus on whether metagenomics will replace the current water safety testing methods or impact the public health end points (e.g., reduction in boil water advisories). Interestingly, experts view the publics relevant in a "downstream capacity" for adoption of metagenomics rather

  17. Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review

    PubMed Central

    Hoare, Derek J.; Nicholson, Richard; Smith, Sandra; Hall, Deborah A.

    2015-01-01

    Objectives: In many countries including the United Kingdom, hearing aids are a first line of audiologic intervention for many people with tinnitus and aidable hearing loss. Nevertheless, there is a lack of high quality evidence to support that they are of benefit for tinnitus, and wide variability in their use in clinical practice especially for people with mild hearing loss. The aim of this study was to identify a consensus among a sample of UK clinicians on the criteria for hearing aid candidature and clinical practice in fitting hearing aids specifically for mild hearing loss with and without tinnitus. This will allow professionals to establish clinical benchmarks and to gauge their practice with that used elsewhere. Design: The Delphi technique, a systematic methodology that seeks consensus amongst experts through consultation using a series of iterative questionnaires, was used. A three-round Delphi survey explored clinical consensus among a panel of 29 UK hearing professionals. The authors measured panel agreement on 115 statements covering: (i) general factors affecting the decision to fit hearing aids, (ii) protocol-driven factors affecting the decision to fit hearing aids, (iii) general practice, and (iv) clinical observations. Consensus was defined as a priori ≥70% agreement across the panel. Results: Consensus was reached for 58 of the 115 statements. The broad areas of consensus were around factors important to consider when fitting hearing aids; hearing aid technology/features offered; and important clinical assessment to verify hearing aid fit (agreement of 70% or more). For patients with mild hearing loss, the greatest priority was given by clinicians to patient-centered criteria for fitting hearing aids: hearing difficulties, motivation to wear hearing aids, and impact of hearing loss on quality of life (chosen as top five by at least 64% of panelists). Objective measures were given a lower priority: degree of hearing loss and shape of the

  18. A Delphi Technology Foresight Study: Mapping Social Construction of Scientific Evidence on Metagenomics Tests for Water Safety.

    PubMed

    Birko, Stanislav; Dove, Edward S; Özdemir, Vural

    2015-01-01

    Access to clean water is a grand challenge in the 21st century. Water safety testing for pathogens currently depends on surrogate measures such as fecal indicator bacteria (e.g., E. coli). Metagenomics concerns high-throughput, culture-independent, unbiased shotgun sequencing of DNA from environmental samples that might transform water safety by detecting waterborne pathogens directly instead of their surrogates. Yet emerging innovations such as metagenomics are often fiercely contested. Innovations are subject to shaping/construction not only by technology but also social systems/values in which they are embedded, such as experts' attitudes towards new scientific evidence. We conducted a classic three-round Delphi survey, comprised of 107 questions. A multidisciplinary expert panel (n = 24) representing the continuum of discovery scientists and policymakers evaluated the emergence of metagenomics tests. To the best of our knowledge, we report here the first Delphi foresight study of experts' attitudes on (1) the top 10 priority evidentiary criteria for adoption of metagenomics tests for water safety, (2) the specific issues critical to governance of metagenomics innovation trajectory where there is consensus or dissensus among experts, (3) the anticipated time lapse from discovery to practice of metagenomics tests, and (4) the role and timing of public engagement in development of metagenomics tests. The ability of a test to distinguish between harmful and benign waterborne organisms, analytical/clinical sensitivity, and reproducibility were the top three evidentiary criteria for adoption of metagenomics. Experts agree that metagenomic testing will provide novel information but there is dissensus on whether metagenomics will replace the current water safety testing methods or impact the public health end points (e.g., reduction in boil water advisories). Interestingly, experts view the publics relevant in a "downstream capacity" for adoption of metagenomics rather

  19. A Delphi Technology Foresight Study: Mapping Social Construction of Scientific Evidence on Metagenomics Tests for Water Safety

    PubMed Central

    Birko, Stanislav; Dove, Edward S.; Özdemir, Vural

    2015-01-01

    Access to clean water is a grand challenge in the 21st century. Water safety testing for pathogens currently depends on surrogate measures such as fecal indicator bacteria (e.g., E. coli). Metagenomics concerns high-throughput, culture-independent, unbiased shotgun sequencing of DNA from environmental samples that might transform water safety by detecting waterborne pathogens directly instead of their surrogates. Yet emerging innovations such as metagenomics are often fiercely contested. Innovations are subject to shaping/construction not only by technology but also social systems/values in which they are embedded, such as experts’ attitudes towards new scientific evidence. We conducted a classic three-round Delphi survey, comprised of 107 questions. A multidisciplinary expert panel (n = 24) representing the continuum of discovery scientists and policymakers evaluated the emergence of metagenomics tests. To the best of our knowledge, we report here the first Delphi foresight study of experts’ attitudes on (1) the top 10 priority evidentiary criteria for adoption of metagenomics tests for water safety, (2) the specific issues critical to governance of metagenomics innovation trajectory where there is consensus or dissensus among experts, (3) the anticipated time lapse from discovery to practice of metagenomics tests, and (4) the role and timing of public engagement in development of metagenomics tests. The ability of a test to distinguish between harmful and benign waterborne organisms, analytical/clinical sensitivity, and reproducibility were the top three evidentiary criteria for adoption of metagenomics. Experts agree that metagenomic testing will provide novel information but there is dissensus on whether metagenomics will replace the current water safety testing methods or impact the public health end points (e.g., reduction in boil water advisories). Interestingly, experts view the publics relevant in a “downstream capacity” for adoption of

  20. Wuchereria bancrofti 20/22 a homologue of abundant larval transcript L3 stage filarial antigen: molecular and immunological characterization.

    PubMed

    Aparnaa, Ramanathan; Mahalakshmi, Natarajan; Harini, Asai; Jeyaprita, Parasurama Jawaharlal; Anugraha, Gandhirajan; Amdare, N P; Khatri, V K; Reddy, M V R; Kaliraj, P

    2014-10-01

    The chromadorea abundant larval transcript (ALT) family of proteins contains ALT one of the most studied putative vaccine candidate in experimental filariasis. This study reports the characterization of Wuchereria bancrofti 20/22 (Wb20/22) as a member of chromadorea, the ALT family of proteins from the L3 stage of W. bancrofti. The high reactivity with serum from the endemic normal (EN) population suggests that Wb20/22 could be a target of elicit protective immunity. The glutamic acid-rich region of Wb20/22 was predicted to harbour the longest linear B-cell epitope by insilico prediction tools. The significance of this region was revealed by studying the mutant form of Wb20/22, without acidic domain (WOAD) which was cloned, and the immune response was compared with Wb20/22. The signal sequence of Wb20/22 was also an immunodominant region, and mutant construct without signal sequence (WOSS) was cloned and characterized. The peak antibody titre elicited by WOAD was higher than Wb20/22 or WOSS, which pointed to the immunomodulatory role of glutamic acid-rich region. Wb20/22 elicited very high levels of IL-10 and diminished levels of IL-4 and IL-5 which could be the reason for low antibody titre. The prophylactic efficacy of WOAD conferred protection (62·26%) which was higher than Wb20/22 (49·82%) and WOSS (54·78%). PMID:24888320

  1. The internal meristem layer (L3) determines floral meristem size and carpel number in tomato periclinal chimeras.

    PubMed

    Szymkowiak, E J; Sussex, I M

    1992-09-01

    Cell-cell interactions are important during plant development. We have generated periclinal chimeras between plants that differ in the number of carpels per flower to determine the roles of cells occupying specific positions in the floral meristem in determining the number of carpels initiated. Intraspecific chimeras were generated between tomato (Lycopersicon esculentum) expressing the mutation fasciated, which causes an increased number of floral organs per whorl, and tomato wild type for fasciated. Interspecific chimeras were generated between tomato and L. peruvianum, which differ in number of carpels per flower. In both sets of chimeras, carpel number as well as the size of the floral meristem during carpel initiation were not determined by the genotype of cells in the outer two layers of the meristem (L1 and L2) but were determined by the genotype of cells occupying the inner layer (L3) of the meristem. We concluded from these experiments that during floral organ initiation, cells in certain layers of the meristem respond to information supplied to them from other cells in the meristem.

  2. Glycosylation of phenolic compounds by the site-mutated β-galactosidase from Lactobacillus bulgaricus L3.

    PubMed

    Lu, Lili; Xu, Lijuan; Guo, Yuchuan; Zhang, Dayu; Qi, Tingting; Jin, Lan; Gu, Guofeng; Xu, Li; Xiao, Min

    2015-01-01

    β-Galactosidases can transfer the galactosyl from lactose or galactoside donors to various acceptors and thus are especially useful for the synthesis of important glycosides. However, these enzymes have limitations in the glycosylation of phenolic compounds that have many physiological functions. In this work, the β-galactosidase from Lactobacillus bulgaricus L3 was subjected to site-saturation mutagenesis at the W980 residue. The recombinant pET-21b plasmid carrying the enzyme gene was used as the template for mutation. The mutant plasmids were transformed into Escherichia coli cells for screening. One recombinant mutant, W980F, exhibited increased yield of glycoside when using hydroquinone as the screening acceptor. The enzyme was purified and the effects of the mutation on enzyme properties were determined in detail. It showed improved transglycosylation activity on novel phenolic acceptors besides hydroquinone. The yields of the glycosides produced from phenol, hydroquinone, and catechol were increased by 7.6% to 53.1%. Moreover, it generated 32.3% glycosides from the pyrogallol that could not be glycosylated by the wild-type enzyme. Chemical structures of these glycoside products were further determined by MS and NMR analysis. Thus, a series of novel phenolic galactosides were achieved by β-galactosidase for the first time. This was a breakthrough in the enzymatic galactosylation of the challenging phenolic compounds of great values.

  3. Glycosylation of Phenolic Compounds by the Site-Mutated β-Galactosidase from Lactobacillus bulgaricus L3

    PubMed Central

    Lu, Lili; Xu, Lijuan; Guo, Yuchuan; Zhang, Dayu; Qi, Tingting; Jin, Lan; Gu, Guofeng; Xu, Li; Xiao, Min

    2015-01-01

    β-Galactosidases can transfer the galactosyl from lactose or galactoside donors to various acceptors and thus are especially useful for the synthesis of important glycosides. However, these enzymes have limitations in the glycosylation of phenolic compounds that have many physiological functions. In this work, the β-galactosidase from Lactobacillus bulgaricus L3 was subjected to site-saturation mutagenesis at the W980 residue. The recombinant pET-21b plasmid carrying the enzyme gene was used as the template for mutation. The mutant plasmids were transformed into Escherichia coli cells for screening. One recombinant mutant, W980F, exhibited increased yield of glycoside when using hydroquinone as the screening acceptor. The enzyme was purified and the effects of the mutation on enzyme properties were determined in detail. It showed improved transglycosylation activity on novel phenolic acceptors besides hydroquinone. The yields of the glycosides produced from phenol, hydroquinone, and catechol were increased by 7.6% to 53.1%. Moreover, it generated 32.3% glycosides from the pyrogallol that could not be glycosylated by the wild-type enzyme. Chemical structures of these glycoside products were further determined by MS and NMR analysis. Thus, a series of novel phenolic galactosides were achieved by β-galactosidase for the first time. This was a breakthrough in the enzymatic galactosylation of the challenging phenolic compounds of great values. PMID:25803778

  4. Superchiral Pd3 L6 Coordination Complex and Its Reversible Structural Conversion into Pd3 L3 Cl6 Metallocycles.

    PubMed

    Jurček, Ondřej; Bonakdarzadeh, Pia; Kalenius, Elina; Linnanto, Juha Matti; Groessl, Michael; Knochenmuss, Richard; Ihalainen, Janne A; Rissanen, Kari

    2015-12-14

    Large, non-symmetrical, inherently chiral bispyridyl ligand L derived from natural ursodeoxycholic bile acid was used for square-planar coordination of tetravalent Pd(II) , yielding the cationic single enantiomer of superchiral coordination complex 1 Pd3 L6 containing 60 well-defined chiral centers in its flower-like structure. Complex 1 can readily be transformed by addition of chloride into a smaller enantiomerically pure cyclic trimer 2 Pd3 L3 Cl6 containing 30 chiral centers. This transformation is reversible and can be restored by the addition of silver cations. Furthermore, a mixture of two constitutional isomers of trimer, 2 and 2', and dimer, 3 and 3', can be obtained directly from L by its coordination to trans- or cis-N-pyridyl-coordinating Pd(II) . These intriguing, water-resistant, stable supramolecular assemblies have been thoroughly described by (1) H DOSY NMR, mass spectrometry, circular dichroism, molecular modelling, and drift tube ion-mobility mass spectrometry.

  5. Comparison of corticosteroid- and L3T4+ antibody-immunosuppressed mouse models of Pneumocystis carinii pneumonia for evaluation of drugs and leukocytes.

    PubMed Central

    Bartlett, M S; Current, W L; Orazi, A; Bauer, N L; Neiman, R S; Queener, S F; Smith, J W

    1994-01-01

    An immunologically immunosuppressed mouse model of Pneumocystis carinii pneumonia using antibody developed by Dialynas et al. (Immunol. Rev. 74:29-55, 1983) directed to L3T4+ T cells (referred to as L3T4+ antibody) was compared with a corticosteroid-immunosuppressed mouse model. Corticosteroid- or L3T4+ antibody-immunosuppressed BALB/c mice transtracheally inoculated with P. carinii developed severe infections within 5 weeks after inoculation and responded to treatments with an echinocandin B analog, LY302146, or trimethoprim plus sulfamethoxazole so that they had decreased numbers of P. carinii cysts and trophozoites. LY302146 appeared to be more effective in L3T4+ antibody-immunosuppressed mice than in dexamethasone-immunosuppressed mice. Leukocyte populations in lungs of both mouse models during development of infection and during treatment were compared by using immune cell-specific staining. Lungs of L3T4+ antibody-immunosuppressed mice had many more cells detected with pan-B antibody and pan-T antibody than dexamethasone-immunosuppressed mice and the lungs of successfully treated mice had about the same numbers of macrophages as those of nonimmunosuppressed uninfected mice. The immunologically immunosuppressed model will allow study of cytokines and other immune modulators alone and in combination with drugs. PMID:8556494

  6. Development of a Cultural Awareness Scale for Occupational Therapy Students in Latin America: A Qualitative Delphi Study.

    PubMed

    Castro, Daniela; Dahlin-Ivanoff, Synneve; Mårtensson, Lena

    2016-06-01

    Cultural awareness is a key issue in healthcare worldwide. Valid and reliable assessments are needed to assess cultural awareness for occupational therapy students. The purpose of this study was to develop a scale to assess cultural awareness for Latin American occupational therapy students. A Delphi design was implemented considering four rounds with experts from four countries. A 30-item scale in Spanish was developed to assess three categories of items: personal, therapeutic strategies and persons' cultures. The experts highlighted local features for professional practice as a key aspect of the scale. Local differences in practice were considered with the profession's traditions and prevailing knowledge across the scale. A participatory strategy and an international group of experts enriched the cultural relevance. A subsequent study of statistical reliability is required (the scale is not presented in an extended version here). Further research should consider the application of the scale and strategies to improve cultural awareness across the curricula. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26800344

  7. Continuous development of schemes for parallel computing of the electrostatics in biological systems: implementation in DelPhi.

    PubMed

    Li, Chuan; Petukh, Marharyta; Li, Lin; Alexov, Emil

    2013-08-15

    Due to the enormous importance of electrostatics in molecular biology, calculating the electrostatic potential and corresponding energies has become a standard computational approach for the study of biomolecules and nano-objects immersed in water and salt phase or other media. However, the electrostatics of large macromolecules and macromolecular complexes, including nano-objects, may not be obtainable via explicit methods and even the standard continuum electrostatics methods may not be applicable due to high computational time and memory requirements. Here, we report further development of the parallelization scheme reported in our previous work (Li, et al., J. Comput. Chem. 2012, 33, 1960) to include parallelization of the molecular surface and energy calculations components of the algorithm. The parallelization scheme utilizes different approaches such as space domain parallelization, algorithmic parallelization, multithreading, and task scheduling, depending on the quantity being calculated. This allows for efficient use of the computing resources of the corresponding computer cluster. The parallelization scheme is implemented in the popular software DelPhi and results in speedup of several folds. As a demonstration of the efficiency and capability of this methodology, the electrostatic potential, and electric field distributions are calculated for the bovine mitochondrial supercomplex illustrating their complex topology, which cannot be obtained by modeling the supercomplex components alone.

  8. Atypical residency of short-beaked common dolphins (Delphinus delphis) to a shallow, urbanized embayment in south-eastern Australia

    PubMed Central

    Salgado Kent, Chandra; Donnelly, David; Weir, Jeffrey; Bilgmann, Kerstin

    2016-01-01

    Short-beaked common dolphins (Delphinus delphis) are typically considered highly mobile, offshore delphinids. This study assessed the residency of a small community of short-beaked common dolphins in the shallow, urbanized Port Phillip Bay, south-eastern Australia. The ability to identify common dolphins by their dorsal fin markings and coloration using photo-identification was also investigated. Systematic and non-systematic boat surveys were undertaken between 2007 and 2014. Results showed that 13 adult common dolphins and their offspring inhabit Port Phillip Bay, of which 10 adults exhibit residency to the bay. The majority of these adults are reproductively active females, suggesting that female philopatry may occur in the community. Systematic surveys conducted between 2012 and 2014 revealed that the dolphins were found in a median water depth of 16 m and median distance of 2.2 km from the coast. The shallow, urbanized habitat of this resident common dolphin community is atypical for this species. As a result, these common dolphins face threats usually associated with inshore bottlenose dolphin communities. We suggest that the Port Phillip Bay common dolphin community is considered and managed separate to those outside the embayment and offshore to ensure the community's long-term viability and residency in the bay. PMID:27703709

  9. Promising behavior change techniques in a multicomponent intervention to reduce concerns about falls in old age: a Delphi study.

    PubMed

    Vestjens, Lotte; Kempen, Gertrudis I J M; Crutzen, Rik; Kok, Gerjo; Zijlstra, G A Rixt

    2015-04-01

    Complex behavior change interventions need evidence regarding the effectiveness of individual components to understand how these interventions work. The objective of this study was to identify the least and most promising behavior change techniques (BCTs) within the Dutch intervention 'A Matter of Balance' (AMB-NL) aimed at concerns about falls in old age as an example. After the identification of 27 BCTs within AMB-NL, an online two-round Delphi survey among 16 international experts was conducted to reach consensus on the least and most promising BCTs. The level of consensus and the level of importance of BCTs were determined. In total, 23 of the 27 (>85%) BCTs identified reached consensus. Most promising BCTs were goal setting (behavior), graded tasks and behavioral practice/rehearsal. Information about health consequences, salience of consequences and information about emotional consequences were considered least promising. These outcomes provide a first but important step in the evidence building process regarding the effectiveness of BCTs in a complex intervention. PMID:25753146

  10. Development of clinical competence assessment tool for novice physical and occupational therapists-a mixed Delphi study.

    PubMed

    Kanada, Yoshikiyo; Sakurai, Hiroaki; Sugiura, Yoshito; Hirano, Yudai; Koyama, Soichiro; Tanabe, Shigeo

    2016-03-01

    [Purpose] The aim of this study was to clarify essential abilities of novice physical and occupational therapists for independent execution of their duties and to develop a clinical competence assessment tool. [Subjects] Forty-five experienced therapists participated in this study. [Methods] A two-phase mixed-methods design was used. First, semi structured interviews were conducted on 15 experienced therapists to create a comprehensive list of essential abilities that novice therapists need. Second, 30 experienced therapists participated in a two-round Delphi study to select items for the assessment tool being developed. [Results] Fifty-five items were extracted and classified into three categories: basic attitudes, therapeutic skills, and clinical practice-related thoughts. [Conclusion] Present results suggest that not only knowledge of execution of therapy-related duties and therapeutic skills is essential in novice therapist, but also appropriate abilities in social adjustment, self-management, and self-education. The newly developed tool might be useful for postgraduate education in clinical practice. PMID:27134395

  11. Developing policy for integrating biomedicine and traditional chinese medical practice using focus groups and the delphi technique.

    PubMed

    Chung, Vincent C H; Ma, Polly H X; Lau, Chun Hong; Griffiths, Sian M

    2012-01-01

    In Hong Kong, statutory regulation for traditional Chinese medicine (TCM) practitioners has been implemented in the past decade. Increasing use of TCM on top of biomedicine (BM) services by the population has been followed; but corresponding policy development to integrate their practices has not yet been discussed. Using focus group methodology, we explore policy ideas for integration by collating views from frontline BM (n = 50) and TCM clinicians (n = 50). Qualitative data were analyzed under the guidance of structuration model of collaboration, a theoretical model for understanding interprofessional collaboration. From focus group findings we generated 28 possible approaches, and subsequently their acceptability was assessed by a two round Delphi survey amongst BM and TCM policy stakeholders (n = 12). Consensus was reached only on 13 statements. Stakeholders agreed that clinicians from both paradigms should share common goals of providing patient-centered care, promoting the development of protocols for shared care and information exchange, as well as strengthening interprofessional connectivity and leadership for integration. On the other hand, attitudes amongst policy stakeholders were split on the possibility of fostering trust and mutual learning, as well as on enhancing innovation and governmental support. Future policy initiatives should focus on these controversial areas.

  12. Institutional Oversight of Faculty-Industry Consulting Relationships in U.S. Medical Schools: A Delphi Study.

    PubMed

    Morain, Stephanie R; Joffe, Steven; Campbell, Eric G; Mello, Michelle M

    2015-01-01

    The conflicts of interest that may arise in relationships between academic researchers and industry continue to prompt controversy. The bulk of attention has focused on financial aspects of these relationships, but conflicts may also arise in the legal obligations that faculty acquire through consulting contracts. However, oversight of faculty members' consulting agreements is far less vigorous than for financial conflicts, creating the potential for faculty to knowingly or unwittingly contract away important rights and freedoms. Increased regulation could prevent this, but it is unclear what forms of oversight universities view as feasible and effective. In this article, we report on a Delphi study to evaluate several approaches for oversight of consulting agreements by medical schools. The panel was comprised of 11 senior administrators with responsibility for oversight of faculty consulting relationships. We found broad agreement among panelists regarding the importance of institutional oversight to protect universities' interests. There was strong support for two specific approaches: providing educational resources to faculty and submitting consulting agreements for institutional review. Notwithstanding the complexities of asserting authority to regulate private consulting agreements between faculty members and companies, medical school administrators reached consensus that several approaches to improving institutional oversight are feasible and useful.

  13. Use of a modified Delphi panel to identify and weight criteria for prioritization of zoonotic diseases in Switzerland.

    PubMed

    Stebler, N; Schuepbach-Regula, G; Braam, P; Falzon, L C

    2015-09-01

    Zoonotic diseases have a significant impact on public health globally. To prevent or reduce future zoonotic outbreaks, there is a constant need to invest in research and surveillance programs while updating risk management strategies. However, given the limited resources available, disease prioritization based on the need for their control and surveillance is important. This study was performed to identify and weight disease criteria for the prioritization of zoonotic diseases in Switzerland using a semi-quantitative research method based on expert opinion. Twenty-eight criteria relevant for disease control and surveillance, classified under five domains, were selected following a thorough literature review, and these were evaluated and weighted by seven experts from the Swiss Federal Veterinary Office using a modified Delphi panel. The median scores assigned to each criterion were then used to rank 16 notifiable and/or emerging zoonoses in Switzerland. The experts weighted the majority of the criteria similarly, and the top three criteria were Severity of disease in humans, incidence and prevalence of the disease in humans and treatment in humans. Based on these weightings, the three highest ranked diseases were Avian Influenza, Bovine Spongiform Encephalitis, and Bovine Tuberculosis. Overall, this study provided a preliminary list of criteria relevant for disease prioritization in Switzerland. These were further evaluated in a companion study which involved a quantitative prioritization method and multiple stakeholders.

  14. What Should Junior Doctors Know about the Drugs they Frequently Prescribe? A Delphi Study among Physicians in the Netherlands.

    PubMed

    Brinkman, David; Disselhorst, Guus; Jansen, Bernard; Tichelaar, Jelle; van Agtmael, Michiel; de Vries, Theo; Richir, Milan

    2016-06-01

    The aim of this study was to identify the information about commonly prescribed drugs that junior doctors should know in order to prescribe rationally in daily practice, defined as essential drug knowledge (EDK). A two-round Internet Delphi study was carried out involving general practitioners from one practice cluster, and registrars and consultants from two Dutch academic and eight teaching hospitals. A preliminary list of 377 potential EDK items for three commonly prescribed drugs was assessed on a dichotomous scale; an item was considered EDK if at least 80% consensus was reached. The consensus list of EDK items was discussed by the research team to identify similarities between the three drugs, with a view to forming a list of general EDK items applicable to other commonly prescribed drugs. Sixty experts considered 93 of the 377 items (25%) as EDK. These items were then used to form a list of 10 general EDK items. The list of EDK items identified by primary and secondary care doctors could be used in medical curricula and training programmes and for assessing the prescribing competence of future junior doctors. Further research is needed to evaluate the generalizability of this list for other commonly prescribed drugs. PMID:26506082

  15. Using the Delphi questionnaire technique to create a reading comprehension resource guide for middle school science teachers

    NASA Astrophysics Data System (ADS)

    Wegner, Molly F.

    As students begin middle school, they are expected to possess and apply a wide array of nonfiction reading strategies if they are to comprehend new concepts from nonfiction texts. Although strategies and resource guides for fiction reading are available, an effective nonfiction reading comprehension resource guide tailored to middle school science teachers is lacking. The conceptual framework guiding this study is based on schema theory that supports the use of prior knowledge as a foundation for learning. The purpose of this project study was to address this local problem by providing middle school science teachers with a user-friendly resource for nonfiction reading comprehension strategies in a science context. The research question examined nonfiction reading comprehension strategies that could supplement middle school science teachers' instructional practices to increase student comprehension in science, as reflected on the results of state standardized tests. This project study consulted science and language arts teachers using a Delphi questionnaire technique to achieve a consensus through multiple iterations of questionnaires. Science teachers identified 7 areas of concern as students read nonfiction texts, and language arts teachers suggested effective reading comprehension strategies to address these areas. Based on the consensus of reading comprehension strategies and review of literature, a resource guide for middle school science teachers was created. By improving reading comprehension in content areas, teachers may not only increase student learning, but also underscore the importance of literacy relating to life-long learning through future occupations, academic endeavors, and society as well.

  16. First Aid Recommendations for Psychosis: Using the Delphi Method to Gain Consensus Between Mental Health Consumers, Carers, and Clinicians

    PubMed Central

    Langlands, Robyn L.; Jorm, Anthony F.; Kelly, Claire M.; Kitchener, Betty A.

    2008-01-01

    Background: Members of the general public often lack the knowledge and skills to intervene effectively to help someone who may be developing a psychotic illness before appropriate professional help is received. Methods: We used the Delphi method to determine recommendations on first aid for psychosis. An international panel of 157 mental health consumers, carers, and clinicians completed a 146-item questionnaire about how a member of the public could help someone who may be experiencing psychosis. The panel members rated each questionnaire item according to whether they believed the statement should be included in the first aid recommendations. The results were analyzed by comparing consensus rates across the 3 groups. Three rounds of ratings were required to consolidate consensus levels. Results: Eighty-nine items were endorsed by ≥80% of panel members from all 3 groups as essential or important for psychosis first aid. These items were grouped under the following 9 headings: how to know if someone is experiencing psychosis; how to approach someone who may be experiencing psychosis; how to be supportive; how to deal with delusions and hallucinations; how to deal with communication difficulties; whether to encourage the person to seek professional help; what to do if the person does not want help; what to do in a crisis situation when the person has become acutely unwell; what to do if the person becomes aggressive. Conclusions: These recommendations will improve the provision of first aid to individuals who are developing a psychotic disorder by informing the content of training courses. PMID:17768307

  17. Use of a modified Delphi approach to develop research priorities for the Association of Coloproctology of Great Britain and Ireland

    PubMed Central

    Tiernan, J; Cook, A; Geh, I; George, B; Magill, L; Northover, J; Verjee, A; Wheeler, J; Fearnhead, N

    2014-01-01

    Aim The modified Delphi approach is an established method for reaching a consensus opinion among a group of experts in a particular field. We have used this technique to survey the entire membership of the Association of Coloproctology of Great Britain and Ireland (ACPGBI) to reach a consensus on prioritizing clinical research questions in colorectal disease. Method Three rounds of surveys were conducted using a web-based tool. In the first, the ACPGBI membership was invited to submit research questions. In Rounds 2 and 3 they were asked to score questions on priority. A steering group analysed the results of each round to identify those questions ranked as being of highest priority. Results Five hundred and two questions were submitted in Round 1. Following two rounds of voting and analysis, a list of 25 priority questions was produced, including 15 cancer-related and 10 noncancer-related questions. Conclusion It is anticipated that these results will: (i) set the research agenda over the next few years for the study of colorectal disease in the United Kingdom, (ii) promote development and (iii) define funding of new research and prioritize areas of unmet clinical need where the potential clinical impact is greatest. PMID:25284641

  18. Identifying the Core Content of a Dermatology Module for Malaysian Medical Undergraduate Curriculum Using a Modified Delphi Method

    PubMed Central

    Jamil, Adawiyah; Muthupalaniappen, Leelavathi; Md Nor, Norazirah; Siraj, Harlina Halizah; Salam, Abdus

    2016-01-01

    Background Dermatology is a minor module in internal medicine undergraduate curriculum. Limited time is allocated for its teaching. Most graduates are inadequately prepared to diagnose and manage skin diseases. We aimed to identify the core content of a more effective dermatology module. Methods A modified Delphi method was used to reach a consensus. A questionnaire was developed by a selected panel and sent to 20 dermatologists, family physicians and general practitioners (GPs), respectively. They were asked to rate diseases according to importance. The participants then answered the questionnaire again with results of the first round made available to them. The final module content was identified based on the panel’s collective opinions. Results Eleven topics had mode and median values of 1 with an agreement level of more than 70%. They were as follows: (1) skin structure and function; (2) infections and infestations; (3) the skin in systemic diseases; (4) dermatology emergencies; (5) drug eruptions; (6) psoriasis; (7) eczema; (8) sexually transmitted infections; (9) leprosy; (10) acne; and (11) clinical skills and diagnostic procedures. A total of 56 diseases were identified as important. Conclusion Results of this study reflect the importance of understanding the influence of regional factors on common and important skin diseases. These topics may be used to develop a more effective dermatology module for the Malaysian undergraduate medical curriculum. PMID:27418873

  19. Measurement of inclusive f1(1285) and f1(1420) production in /Z decays with the DELPHI detector

    NASA Astrophysics Data System (ADS)

    DELPHI Collaboration; Abdallah, J.; Abreu, P.; Adam, W.; Adzic, P.; Albrecht, T.; Alderweireld, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P. P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.-D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J. E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.-H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Berntzon, L.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P. S. L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T. J. V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J. M.; Bugge, L.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, N.; Cavallo, F.; Chapkin, M.; Charpentier, Ph.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S. U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M. J.; Crawley, B.; Crennell, D.; Cuevas, J.; D'Hondt, J.; Dalmau, J.; da Silva, T.; da Silva, W.; della Ricca, G.; de Angelis, A.; de Boer, W.; de Clercq, C.; de Lotto, B.; de Maria, N.; de Min, A.; de Paula, L.; di Ciaccio, L.; di Simone, A.; Doroba, K.; Drees, J.; Dris, M.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Espirito Santo, M. C.; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, Ph.; Gazis, E.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Hansen, J.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Herr, H.; Hoffman, J.; Holmgren, S.-O.; Holt, P. J.; Houlden, M. A.; Hultqvist, K.; Jackson, J. N.; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, E. K.; Johansson, P. D.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, F.; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B. P.; Kiiskinen, A.; King, B. T.; Kjaer, N. J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, F.; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J. H.; Lopez, J. M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.-C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; Mc Nulty, R.; Meroni, C.; Meyer, W. T.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Moenig, K.; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J. P.; Palka, H.; Papadopoulou, Th. D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M. E.; Polok, G.; Poropat, P.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Rames, J.; Ramler, L.; Read, A.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Rosenberg, E.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Savoy-Navarro, A.; Schwickerath, U.; Segar, A.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Taffard, A. C.; Tegenfeldt, F.; Timmermans, J.; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.-L.; Tyapkin, I. A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; van Dam, P.; van Eldik, J.; van Lysebetten, A.; van Remortel, N.; van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verbeure, F.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A. J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimin, N. I.; Zintchenko, A.; Zupan, M.

    2003-09-01

    DELPHI results are presented on the inclusive production of two (KKπ)0 states in the mass region 1.2-1.6 GeV/c2 in hadronic /Z decays at LEP I. The measured masses (widths) are /1274+/-6 MeV/c2 (/29+/-12 MeV/c2) and /1426+/-6 MeV/c2 (/51+/-14 MeV/c2), respectively. A partial-wave analysis of the (KKπ)0 system shows that the first peak is consistent with the IG(JPC)=0+(1++)/(0-+)a0(980)π and the second with the IG(JPC)=0+(1++)K*(892)K+c.c. assignments. The total hadronic production rates per hadronic /Z decay are /(0.165+/-0.051) and /(0.056+/-0.012), respectively. These measurements are consistent with the two states being the f1(1285) and f1(1420) mesons.

  20. Measurement of inclusive f1(1285) and f1(1420) production in Z decays with the DELPHI detector

    NASA Astrophysics Data System (ADS)

    Abdallah, J.; Abreu, P.; Adam, W.; Adzic, P.; Albrecht, T.; Alderweireld, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P. P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.-D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J. E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.-H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Berntzon, L.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P. S. L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T. J. V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J. M.; Bugge, L.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, N.; Cavallo, F.; Chapkin, M.; Charpentier, Ph.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S. U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M. J.; Crawley, B.; Crennell, D.; Cuevas, J.; D'Hondt, J.; Dalmau, J.; da Silva, T.; da Silva, W.; Della Ricca, G.; de Angelis, A.; de Boer, W.; de Clercq, C.; de Lotto, B.; de Maria, N.; de Min, A.; de Paula, L.; di Ciaccio, L.; di Simone, A.; Doroba, K.; Drees, J.; Dris, M.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Espirito Santo, M. C.; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, Ph.; Gazis, E.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Hansen, J.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Herr, H.; Hoffman, J.; Holmgren, S.-O.; Holt, P. J.; Houlden, M. A.; Hultqvist, K.; Jackson, J. N.; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, E. K.; Johansson, P. D.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, F.; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B. P.; Kiiskinen, A.; King, B. T.; Kjaer, N. J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, F.; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J. H.; Lopez, J. M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.-C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; Mc Nulty, R.; Meroni, C.; Meyer, W. T.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Moenig, K.; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J. P.; Palka, H.; Papadopoulou, Th. D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M. E.; Polok, G.; Poropat, P.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Rames, J.; Ramler, L.; Read, A.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Rosenberg, E.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Savoy-Navarro, A.; Schwickerath, U.; Segar, A.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Taffard, A. C.; Tegenfeldt, F.; Timmermans, J.; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.-L.; Tyapkin, I. A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; van Dam, P.; van Eldik, J.; van Lysebetten, A.; van Remortel, N.; van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verbeure, F.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A. J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimin, N. I.; Zintchenko, A.; Zupan, M.; Delphi Collaboration

    2003-09-01

    DELPHI results are presented on the inclusive production of two (KoverlineKπ)0 states in the mass region 1.2-1.6 GeV/c2 in hadronic Z decays at LEP I. The measured masses (widths) are 1274±6 MeV/c2 (29±12 MeV/c2) and 1426±6 MeV/c2 (51±14 MeV/c2), respectively. A partial-wave analysis of the (KoverlineKπ)0 system shows that the first peak is consistent with the IG(JPC)=0+(1++)/(0-+)a0(980)π and the second with the IG(JPC)=0+(1++)K∗(892)overlineK+c.c. assignments. The total hadronic production rates per hadronic Z decay are (0.165±0.051) and (0.056±0.012), respectively. These measurements are consistent with the two states being the f1(1285) and f1(1420) mesons.