Science.gov

Sample records for alexander von humbolt

  1. [Researchers training in the context of the collaborative projects: experiences of Instituto de Medicina Tropical "Alexander von Humbolt", Universidad Peruana Cayetano Heredia].

    PubMed

    Gotuzzo, Eduardo; González, Elsa; Verdonck, Kristien

    2010-09-01

    Research is a main element for human and social development. Under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". An approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). Both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. We present here the experiences of the Instituto de Medicina Tropical "Alexander von Humboldt" of the Universidad Peruana Cayetano Heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.

  2. Alexander von Humboldt: a revolutionary explorer.

    PubMed

    Fara, Patricia

    2008-03-01

    After he returned from his five-year expedition to the New World, Alexander von Humboldt promoted himself as a Romantic explorer. Although this image pervades British perceptions, political movements have fashioned different heroic versions of Humboldt in Germany and South America.

  3. Alexander von Humboldt's perceptions of colonial Spanish America.

    PubMed

    Rebok, Sandra

    2009-01-01

    This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind. PMID:19852391

  4. Alexander von Humboldt's perceptions of colonial Spanish America.

    PubMed

    Rebok, Sandra

    2009-01-01

    This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind.

  5. Alexander von Humboldt's charts of the Earth's magnetic field: an assessment based on modern models

    NASA Astrophysics Data System (ADS)

    Mandea, M.; Korte, M.; Soloviev, A.; Gvishiani, A.

    2010-11-01

    The 19th century witnessed a resurgence of interest in Earth's magnetic field. Both observational and theoretical aspects were involved, and one of the emblematic figures of this period was Alexander von Humboldt. Throughout a long life he maintained a strong interest in a broad area of subjects, however, here we are interested in his role in geomagnetism, and particularly in his pioneering contributions to charting the geomagnetic field. Alexander von Humboldt efforts in measuring and charting the Earth's magnetic field are recounted and the maps of declination, inclination and total intensity he had prepared are compared, favorably, with maps for the same epoch based on a modern model of the geomagnetic field, gufm1. This modern assessment of the accuracy of von Humboldt's geomagnetic charts illustrates the importance of his work, being also our homage to the 150th anniversary of the death of Alexander von Humboldt.

  6. [Urology and National Socialism: the fate of Alexander von Lichtenberg 1880-1949].

    PubMed

    Moll, F H; Krischel, M; Rathert, P; Fangerau, H

    2010-09-01

    Alexander von Lichtenberg (1880-1949) was one of the famous members of the German Urological Society (DGU) in pre-war Germany. He introduced excretion urography and a special TURP Instrument. In 1928 he was president of the 8th meeting held in the German capital Berlin. His Handbook of Urology, released by Ferdinand Springer publishing house, was a trendsetter in establishing urology as a specialty in Germany and bringing together the whole wisdom of all aspects of urology. He was the founder of the famous Maximilian Nitze Award of the DGU. As a Jew he-like many others-was forced to leave Nazi Germany after 1933. Even in Hungary, his native country, he again had to resist anti-Semitic hostility. Later on he lived in Mexico. Alexander von Lichtenberg has to be remembered with special focus on the exodus of German Jewish scientists during the Nazi time.

  7. Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 1: formative years, naturphilosophie, and galvanism.

    PubMed

    Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

    2013-01-01

    During the 1790s, Alexander von Humboldt (1769-1859), who showed an early interest in many facets of natural philosophy and natural history, delved into the controversial subject of galvanism and animal electricity, hoping to shed light on the basic nature of the nerve force. He was motivated by his broad worldview, the experiments of Luigi Galvani, who favored animal electricity in more than a few specialized fishes, and the thinking of Alessandro Volta, who accepted specialized fish electricity but was not willing to generalize to other animals, thinking Galvani's frog experiments flawed by his use of metals. Differing from many German Naturphilosophen, who shunned "violent" experiments, the newest instruments, and detailed measurement, Humboldt conducted thousands of galvanic experiments on animals and animal parts, as well as many on his own body, some of which caused him great pain. He interpreted his results as supporting some but not all of the claims made by both Galvani and Volta. Notably, because of certain negative findings and phenomenological differences, he remained skeptical about the intrinsic animal force being qualitatively identical to true electricity. Hence, he referred to a "galvanic force," not animal electricity, in his letters and publications, a theoretical position he would abandon with Volta's help early in the new century.

  8. Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 1: formative years, naturphilosophie, and galvanism.

    PubMed

    Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

    2013-01-01

    During the 1790s, Alexander von Humboldt (1769-1859), who showed an early interest in many facets of natural philosophy and natural history, delved into the controversial subject of galvanism and animal electricity, hoping to shed light on the basic nature of the nerve force. He was motivated by his broad worldview, the experiments of Luigi Galvani, who favored animal electricity in more than a few specialized fishes, and the thinking of Alessandro Volta, who accepted specialized fish electricity but was not willing to generalize to other animals, thinking Galvani's frog experiments flawed by his use of metals. Differing from many German Naturphilosophen, who shunned "violent" experiments, the newest instruments, and detailed measurement, Humboldt conducted thousands of galvanic experiments on animals and animal parts, as well as many on his own body, some of which caused him great pain. He interpreted his results as supporting some but not all of the claims made by both Galvani and Volta. Notably, because of certain negative findings and phenomenological differences, he remained skeptical about the intrinsic animal force being qualitatively identical to true electricity. Hence, he referred to a "galvanic force," not animal electricity, in his letters and publications, a theoretical position he would abandon with Volta's help early in the new century. PMID:23581538

  9. Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 2: the electric eel, animal electricity, and later years.

    PubMed

    Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

    2013-01-01

    After extensive experimentation during the 1790s, Alexander von Humboldt remained skeptical about "animal electricity" (and metallic electricity), writing instead about an ill-defined galvanic force. With his worldview and wishing to learn more, he studied electric eels in South America just as the new century began, again using his body as a scientific instrument in many of his experiments. As had been the case in the past and for many of the same reasons, some of his findings with the electric eel (and soon after, Italian torpedoes) seemed to argue against biological electricity. But he no longer used galvanic terminology when describing his electric fish experiments. The fact that he now wrote about animal electricity rather than a different "galvanic" force owed much to Alessandro Volta, who had come forth with his "pile" (battery) for multipling the physical and perceptable effects of otherwise weak electricity in 1800, while Humboldt was deep in South America. Humboldt probably read about and saw voltaic batteries in the United States in 1804, but the time he spent with Volta in 1805 was probably more significant in his conversion from a galvanic to an electrical framework for understanding nerve and muscle physiology. Although he did not continue his animal electricity research program after this time, Humboldt retained his worldview of a unified nature and continued to believe in intrinsic animal electricity. He also served as a patron to some of the most important figures in the new field of electrophysiology (e.g., Hermann Helmholtz and Emil du Bois-Reymond), helping to take the research that he had participated in to the next level.

  10. Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences

    NASA Astrophysics Data System (ADS)

    Laj, Carlo; Cifelli, Francesca

    2015-04-01

    The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. These GIFT workshops represented the first workshops specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

  11. Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences.

    NASA Astrophysics Data System (ADS)

    Laj, C. E.; Cifelli, F.

    2014-12-01

    Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. In 3 cases of the 4 cases, these GIFT workshops represented the first workshop specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

  12. Measuring the World: How theory follows observation (Alexander von Humboldt Medal)

    NASA Astrophysics Data System (ADS)

    Savenije, Hubert H. G.

    2015-04-01

    I started my professional career as a hydrologist working for the government of Mozambique. I was responsible for overseeing the hydrological network, the operational hydrology and answering specific questions related to water resources availability and the occurrence of floods. In the late 1970s and early 1980s, the use of telecommunication and computers was still very limited. We had to work with handbooks, lecture notes and consultancy reports, but mostly with our brains. The key to answering a specific question was to go into the field and observe. We measured as much as we could to understand the processes that we observed. I didn't know it at the time, but this perfectly fits in the tradition of Von Humboldt. During my time in Mozambique I surveyed during and after extreme floods, such as the 1984 flood caused by the tropical cyclone Demoina. I surveyed the geometry, hydraulics and salt intrusion of 4 major Mozambican estuaries. And I measured the quality and the quantity of the flows draining onto these estuaries. Having only limited access to the literature, it was a survey without much theoretical guidance. This maybe slowed us down a bit, and sometimes led to inefficient approaches, but scientifically it was a gold mine. Not being biased by established theories is a great advantage. One does not follow onto the well-trodden, but sometimes erroneous, paths of others. After working for 6 years in Mozambique I joined an international consultant, for whom I worked for 6 years in many different countries in Asia, Africa and South America. Although the access to literature and other people's experience was better, I continued the practice of observing before believing. These 12 years of doing hydrology in practice formed the basis for the development of my own theories on hydrological processes, salt intrusion in estuaries, tidal hydraulics and even atmospheric moisture recycling. So when I started on my PhD at the age of 38, I made a completely different start

  13. Alexander I. Ignatowski

    PubMed Central

    Konstantinov, Igor E.; Jankovic, Gradimir M.

    2013-01-01

    In 1908, Alexander I. Ignatowski (1875–1955) published his pioneering work that first revealed a relationship between cholesterol-rich food and experimental atherosclerosis. This early experimental work paved a way to the metabolic study of the mechanism of atherosclerosis. Herein, we present a brief account of Ignatowski's work and life. PMID:23914012

  14. Alexander Archipelago, Southeastern Alaska

    NASA Technical Reports Server (NTRS)

    2002-01-01

    West of British Columbia, Canada, and south of the Yukon Territory, the southeastern coastline of Alaska trails off into the islands of the Alexander Archipelago. The area is rugged and contains many long, U-shaped, glaciated valleys, many of which terminate at tidewater. The Alexander Archipelago is home to Glacier Bay National Park. The large bay that has two forks on its northern end is Glacier Bay itself. The eastern fork is Muir inlet, into which runs the Muir glacier, named for the famous Scottish-born naturalist John Muir. Glacier Bay opens up into the Icy Strait. The large, solid white area to the west is Brady Icefield, which terminates at the southern end in Brady's Glacier. To locate more interesting features from Glacier Bay National Park, take a look at the park service map. As recently as two hundred years ago, a massive ice field extended into Icy Strait and filled the Glacier Bay. Since that time, the area has experienced rapid deglaciation, with many large glaciers retreating 40, 60, even 80 km. While temperatures have increased in the region, it is still unclear whether the rapid recession is part of the natural cycle of tidewater glaciers or is an indicator of longer-term climate change. For more on Glacier Bay and climate change, read an online paper by Dr. Dorothy Hall, a MODIS Associate Science Team Member. Credit: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

  15. What killed Alexander the Great?

    PubMed

    Battersby, Cameron

    2007-01-01

    The cause of the death of the Macedonian King, Alexander the Great, at Babylon in 323 BC has excited interest and conjecture throughout the ages. The information available in the surviving ancient sources, none of which is contemporaneous, has been reviewed and compared with modern knowledge as set out in several well-known recent surgical texts. The ancient sources record epic drinking by the Macedonian nobility since at least the time of Phillip II, Alexander's father. Alexander's sudden illness and death is likely to have resulted from a surgical complication of acute alcoholic excess.

  16. Alexander Lowen: An Energetic Man.

    ERIC Educational Resources Information Center

    Good, Glenn E.; Rabinowitz, Fredric E.

    1992-01-01

    Presents interview with Alexander Lowen, prominent psychotherapist, who discusses his personal and professional development, as well as the evolution of bioenergetic analysis. Includes a list of suggested readings by Lowen. (Author/NB)

  17. An Interview with Lloyd Alexander.

    ERIC Educational Resources Information Center

    Tunnell, Michael O.

    1989-01-01

    Probes Lloyd Alexander's thoughts about his own writing habits and processes; his reflections on his various books and characters; the state of children's publishing today; and fan mail he receives. (RAE)

  18. Alexander A Friedmann

    NASA Astrophysics Data System (ADS)

    Tropp, Eduard A.; Frenkel, Viktor Ya.; Chernin, Artur D.

    1993-06-01

    Our universe can be described mathematically by a simple model developed in 1922 at Petrograd (St. Petersburg) by Alexander Friedmann (1888-1925). Without the benefit of observational evidence, Friedmann predicted that the whole universe would expand and evolve with time. This astonishing prediction was confirmed seven years later by Edwin Hubble. Its originator, unfortunately didn't live to savor this triumph. This vivid biography of an outstanding scientist sets his life and work against a wide backdrop of the history of cosmological studies and its major players, such as Einstein and others. The book is a window on Friedmann's school and university years, military service, and teaching and research during a seminal period of Soviet history. The authors include unique archival material, such as Friedmann's letters from the Russian Front, as well as contemporary records and reminiscences of colleagues. There is a detailed treatment of his work in theoretical cosmology (1922-1924), set in the context of the organization of Soviet science at the time.

  19. Conjecture of Alexander and Orbach.

    NASA Astrophysics Data System (ADS)

    Rudra, Jayanta; Doiron, Curtis

    2009-03-01

    The dynamical properties of fractal networks have received wide range of attention. Works on this area by several pioneering authors^1-2 have led to the introduction of the spectral dimension that dictates the dynamic properties on a fractal lattice. Most of the studies involving spectral dimension have been performed on a type of fractal lattice known as percolation network. Alexander and Orbach^2 conjectured that the spectral dimension might be exactly 4/3 for percolation networks with Euclidean dimension de >= 2. Recent numerical simulations, however, could not decisively prove or disprove this conjecture, although there are other indirect evidences that it is true. We apply a stochastic approach^3 to determine the spectral dimension of percolation network for de >= 2 and check the validity of the Alexander-Orbach conjecture. Our preliminary results on 2- and 3-dimensional percolation networks indeed show that Alexander-Orbach conjecture is true, resolving a long-standing debate. References: 1. P. G. deGennes, La Recherche 7 (1976) 919. 2. S. Alexander and R. Orbach, J. Phys. Lett. (Paris) 43 (1982) L625. 3. J. Rudra and J. Kozak, Phys. Lett A 151 (1990) 429.

  20. Commentary. The diseases of Alexander the Great.

    PubMed

    York, George K; Steinberg, David A

    2004-06-01

    The accompanying articles that speculate that Alexander the Great had a traumatic carotid dissection or congenital cervical scoliosis demonstrate the difficulties in retrospective diagnosis as a historical enterprise. The extant primary sources were written centuries after Alexander's death and are ambiguous in their original languages, and even more so in translation. Thus we cannot be certain what illness Alexander actually had. Furthermore, anachronistic diagnosis removes Alexander from the medical context of this time, telling us little of historical significance about him. Such investigations also illustrate the more general limits that the absence of context imposes on the study of ancient history.

  1. Dancers' Application of the Alexander Technique

    ERIC Educational Resources Information Center

    Fortin, Sylvie; Girard, Fernande

    2005-01-01

    This qualitative study describes the experience of professional contemporary dancers studying and applying the Alexander Technique to their dancing. This study was motivated by: 1. years of teaching both dance and somatics, 2. a strong desire to better understand how the Alexander Technique can be applied by dancers, and 3. a gap that the…

  2. Cupola Corner 2 - Conversation With Alexander Samokutyaev

    NASA Video Gallery

    Astronaut Ron Garan speaks with fellow Expedition 28 flight engineer and Soyuz Commander Alexander Samokutyaev about using the view from the International Space Station to inspire people to make a ...

  3. The Haunting Influence of Alexander Graham Bell

    ERIC Educational Resources Information Center

    Mitchell, Sue H.

    1971-01-01

    The article examines the significance that Alexander Graham Bell's attitude and actions had on the social and economic conditions experienced by deaf people during his lifetime and into the present. (CD)

  4. A psychoanalytic study of Alexander the Great.

    PubMed

    Thomas, K R

    1995-12-01

    The purpose of this paper was to demonstrate how Freudian concepts such as the Oedipus complex, castration anxiety, fear of loss of love, the psychosexual stages of development, and the tripartite structure of personality can be used to understand the life and achievements of Alexander the Great. To accomplish this purpose, specific incidents, myths, and relationships in Alexander's life were analyzed from a Freudian psychoanalytic perspective. Green (1991), in his recent biography of Alexander, has questioned the merit of using Freudian concepts to understand Alexander's character. In fact, he stated specifically: If he (Alexander) had any kind of Oedipus complex it came in a poor second to the burning dynastic ambition which Olympias so sedulously fostered in him; those who insist on his psychological motivation would do better to take Adler as their mentor than Freud (p.56). Later, in the concluding section of his book, Green (1991, pp. 486-487) discounted Freudian interpretations of Alexander's distaste for sex, the rumors of his homosexual liaisons, his partiality for middle-aged or elderly ladies, and the systematic domination of his early years by Olympias as little more than the projected fears and desires of the interpreters. And again, an Adlerian power-complex paradigm was suggested as the preferable theoretical framework to use. Green's argument was based primarily on an exchange, reported originally by Plutarch, which took place between Alexander and Philip prior to Alexander's tutorship with Aristotle. Purportedly, Philip enjoined his son to study hard and pay close attention to all Aristotle said "so that you may not do a great many things of the sort that I am sorry I have done." At this point, Alexander "somewhat pertly" took Philip to task "because he was having children by other women besides his wife." Philip's reply was: "Well then, if you have many competitors for the kingdom, prove yourself honorable and good, so that you may obtain the

  5. GFAP and its role in Alexander Disease

    PubMed Central

    Quinlan, Roy A; Brenner, Michael; Goldman, James E.; Messing, Albee

    2009-01-01

    Here we review how GFAP mutations cause Alexander disease. The current data suggest that a combination of events cause the disease. These include: i) the accumulation of GFAP and the formation of characteristic aggregates, called Rosenthal fibres, ii) the sequestration of the protein chaperones αB-crystallin and HSP27 into Rosenthal fibres, and iii) the activation of both Jnk and the stress response. These then set in motion events that lead to Alexander disease. We discuss parallels with other intermediate filament diseases and assess potential therapies as part of this review as well as emerging trends in disease diagnosis and other aspects concerning GFAP. PMID:17498694

  6. The Mind-Body Connection: An Introduction to Alexander Technique.

    ERIC Educational Resources Information Center

    Madden, Cathy

    2003-01-01

    Explains that the Alexander Technique is a process that allows performers to improve physical-mental coordination while performing. Outlines the fundamentals of the Alexander Technique and how it can be applied for actors and drama teachers. Proposes that drama teachers can incorporate some of the Alexander Technique's fundamentals into their…

  7. Alexander Technique and Dance Technique: Applications in the Studio

    ERIC Educational Resources Information Center

    Nettl-Fiol, Rebecca

    2006-01-01

    Integrating principles from the Alexander Technique into a dance technique class can provide tools for facilitating a more coordinated use of the self. While the methodologies of Alexander Technique and dance technique may present differences, there are ways of applying the principles of Alexander within the context of a dance technique class that…

  8. The Remarkable Journey of Lloyd Alexander

    ERIC Educational Resources Information Center

    Tunnel, Michael O.; Jacobs, James S.

    2007-01-01

    This article features Lloyd Alexander, an author who has produced some of the most elegant and powerful prose in the history of modern children's literature. Lloyd began writing seriously in high school, and though he wrote and submitted many poems and short stories, his only success was being named a finalist in the "Writer's Digest" Short Story…

  9. Alexander Graham Bell: Teacher of the Deaf.

    ERIC Educational Resources Information Center

    Bruce, Robert V.

    The lecture on Alexander Graham Bell by Dr. Robert V. Bruce, the author of a biography of Bell, focuses on Bell's association with the Clarke School for the Deaf in Massachusetts. Noted are Bell's employment by the school at 25 years of age and the preceding period during which Bell taught elocution at a boys' school in Scotland and used his…

  10. 3. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 VIEW FROM SOUTHWEST - Felix & Odile Pratt Valle House, Merchant & Second Streets, Sainte Genevieve, Ste. Genevieve County, MO

  11. 5. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 DETAIL OF BASEMENT FIREPLACE - Indian Trading Post, Second & Merchant Streets, Sainte Genevieve, Ste. Genevieve County, MO

  12. 2. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 DETAIL OF ENTRANCE (WEST ELEVATION - FRONT) - Eugene Field House, 634 South Broadway, Saint Louis, Independent City, MO

  13. 4. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 DETAIL OF STONEWORK (WEST ELEVATION) - Indian Trading Post, Second & Merchant Streets, Sainte Genevieve, Ste. Genevieve County, MO

  14. 1. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 VIEW FROM NORTHEAST - Felix & Odile Pratt Valle House, Merchant & Second Streets, Sainte Genevieve, Ste. Genevieve County, MO

  15. 2. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 VIEW FROM NORTHWEST - Felix & Odile Pratt Valle House, Merchant & Second Streets, Sainte Genevieve, Ste. Genevieve County, MO

  16. "Most brilliant in judgment": Alexander the Great and Aristotle.

    PubMed

    Lainas, Panagiotis; Panutsopulos, Dimitrios; Skandalakis, Panagiotis N; Zoras, Odysseas; Skandalakis, John E

    2005-03-01

    From historical sources, it is evident that Alexander the Great was indebted to one of his teachers, Aristotle of Stagira. It was the teaching of Aristotle that evoked all the nascent talents of young Alexander and turned him into a great man. Alexander was extremely interested in the secrets of medicine and considered it an art. The medical knowledge he acquired from Aristotle may have saved his life and the lives of his troops on many occasions. If Alexander did not possess medical knowledge and if his everyday life had not been so greatly influenced by medicine, he might never have been able to create his empire.

  17. 3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ENTRANCE STOOP (LION FIGURE) - Joseph Beale House, 2301 Massachusetts Avenue, Northwest, Washington, District of Columbia, DC

  18. 4. Historic American Buildings Survey J. Alexander, Photographer August 1968 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey J. Alexander, Photographer August 1968 BEDROOM FIREPLACE, THIRD FLOOR - Andrew Ross Tenant House II, 1210 Thirtieth Street Northwest, Washington, District of Columbia, DC

  19. 3. Historic American Buildings Survey J. Alexander, Photographer August 1968 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey J. Alexander, Photographer August 1968 SECOND FLOOR PARLOR FIREPLACE - Andrew Ross Tenant House II, 1210 Thirtieth Street Northwest, Washington, District of Columbia, DC

  20. 2. NORTH AND EAST ELEVATIONS, ALEXANDER'S MILL (WILSON'S MILL). THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. NORTH AND EAST ELEVATIONS, ALEXANDER'S MILL (WILSON'S MILL). THE 2-1/1-STORY MAIN BLOCK, ERECTED IN 1855, HAS OVERTONES OF THE GREEK REVIVAL STYLE. Photographer: louise Taft Cawood, July 1986 - Alexander's Grist Mill, Lock 37 on Ohio & Erie Canal, South of Cleveland, Valley View, Cuyahoga County, OH

  1. Heterangaeus Alexander, 1925 crane flies (Diptera: Pediciidae) of Korea.

    PubMed

    Podenas, Sigitas; Podeniene, Virginija; Byun, Hye-Woo

    2015-01-01

    The Korean crane fly species of the genus Heterangaeus Alexander, 1925 (Diptera: Pediciidae) is taxonomically revised. H. gloriosus gloriosus (Alexander, 1924) is redescribed. A new species Heterangaeus koreanus n. sp., which is the first species of Pediciidae from South Korea, is described and illustrated.

  2. Von Humboldt bis Einstein. Berlin als Weltzentrum der exakten Wissenschaften.

    NASA Astrophysics Data System (ADS)

    Meschkowski, H.

    Contents: 1. Die Anfänge. 2. Die Ära Dirichlet-Jacobi. 3. Der Ausbau der experimentellen Naturwissenschaften. 4. Alexander von Humboldt. 5. Berlin wird "Weltzentrum" der Mathematik. 6. Die Ära Helmholtz. 7. Neue Arbeitsweisen der Astronomie. 8. Chemie: Forschung und Industrie. 9. Max Planck. 10. Ins technische Zeitalter. 11. Zur Mathematik der zwanziger Jahre. 12. Albert Einstein. 13. Fortschritte der Grundlagenforschung. 14. Erwin Schrödinger: Physiker, Philosoph und Poet. 15. Zum Schluß.

  3. Alexander's disease: clinical, pathologic, and genetic features.

    PubMed

    Johnson, Anne B; Brenner, Michael

    2003-09-01

    Alexander's disease, a rare and fatal disorder of the central nervous system, most commonly affects infants and young children but can also occur in older children and sometimes adults. In infants and young children, it causes developmental delay, psychomotor retardation, paraparesis, feeding problems, usually megalencephaly, often seizures, and sometimes hydrocephalus. Juvenile cases often do not have megalencephaly and tend to have predominant pseudobulbar and bulbar signs. In both groups, characteristic magnetic resonance imaging findings have been described. In adult cases, the signs are variable, can resemble multiple sclerosis, and might include palatal myoclonus. In all cases, the examination of brain tissue shows the presence of widely distributed Rosenthal fibers. Almost all cases have recently been found to have a heterozygous, missense, point mutation in the gene for glial fibrillary acidic protein, which provides a new diagnostic tool. In most cases, the mutation appears to occur de novo, not being present in either parent, but some adult cases are familial.

  4. The death of Alexander the Great: malaria or typhoid fever?

    PubMed

    Cunha, Burke A

    2004-03-01

    Alexander the Great had a profound effect on world history. His conquests covered the entire known world at the time, and he was responsible for the spread of Greek culture throughout the ancient world. In Babylon in 323 BC, Alexander died when he was nearly 33 years old. Possible explanations for his death have included alcoholic liver disease and strychnine poisoning, but little data support either condition as the cause of his death. Alexander most likely died from malaria or typhoid fever, which were rampant in ancient Babylon. The description of his final illness from the royal diaries is consistent with typhoid fever or malaria but is most characteristic of typhoid fever.

  5. 1. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 VIEW FROM SOUTHWEST - Second & Gabourie Streets (Old Stone House), Corner of Second & Gabourie Streets, Sainte Genevieve, Ste. Genevieve County, MO

  6. 2. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 DETAIL OF STONEWORK (SOUTHWEST CORNER) - Second & Gabourie Streets (Old Stone House), Corner of Second & Gabourie Streets, Sainte Genevieve, Ste. Genevieve County, MO

  7. 1. Historic American Buildings Survey J. Alexander, Photographer April 1969 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey J. Alexander, Photographer April 1969 3034 P STREET (right) AND ADJOINING ROWHOUSES, LOOKING EAST - Smith-Morton Row House, 3034 P Street Northwest, Washington, District of Columbia, DC

  8. Alexander disease with mild dorsal brainstem atrophy and infantile spasms.

    PubMed

    Torisu, Hiroyuki; Yoshikawa, Yoko; Yamaguchi-Takada, Yui; Yano, Tamami; Sanefuji, Masafumi; Ishizaki, Yoshito; Sawaishi, Yukio; Hara, Toshiro

    2013-05-01

    We present the case of a Japanese male infant with Alexander disease who developed infantile spasms at 8 months of age. The patient had a cluster of partial seizures at 4 months of age. He presented with mild general hypotonia and developmental delay. Macrocephaly was not observed. Brain magnetic resonance imaging (MRI) findings fulfilled all MRI-based criteria for the diagnosis of Alexander disease and revealed mild atrophy of the dorsal pons and medulla oblongata with abnormal intensities. DNA analysis disclosed a novel heterozygous missense mutation (c.1154 C>T, p.S385F) in the glial fibrillary acidic protein gene. At 8 months of age, tonic spasms occurred, and electroencephalography (EEG) revealed hypsarrhythmia. Lamotrigine effectively controlled the infantile spasms and improved the abnormal EEG findings. Although most patients with infantile Alexander disease have epilepsy, infantile spasms are rare. This comorbid condition may be associated with the distribution of the brain lesions and the age at onset of Alexander disease.

  9. 8. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 INTERIOR VIEW LOOKING UP INTO THE DOME - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  10. 5. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 Detail of Rotunda looking west. - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  11. 1. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 GENERAL VIEW FROM NORTHEAST - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  12. 7. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 DETAIL OF ROTUNDA LOOKING NORTH - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  13. 6. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 DETAIL OF ROTUNDA - LOOKING NORTH - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  14. 2. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 DETAIL OF EAST PORTICO - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  15. 2. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 VIEW FROM SOUTHWEST - Jean Baptiste Valle House, 99 South Main Street (Northwest corner of Main & Market Streets), Sainte Genevieve, Ste. Genevieve County, MO

  16. 1. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 VIEW FROM SOUTHEAST - Jean Baptiste Valle House, 99 South Main Street (Northwest corner of Main & Market Streets), Sainte Genevieve, Ste. Genevieve County, MO

  17. 3. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Alexander Piaget, Photographer, April 10, 1934 VIEW FROM NORTH - Jean Baptiste Valle House, 99 South Main Street (Northwest corner of Main & Market Streets), Sainte Genevieve, Ste. Genevieve County, MO

  18. 1. Historic American Buildings Survey J. Alexander, Photographer February 1969 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey J. Alexander, Photographer February 1969 EAST ELEVATIONS OF 1208-10 30th STREET - Andrew Ross Tenant House II, 1210 Thirtieth Street Northwest, Washington, District of Columbia, DC

  19. 2. Historic American Buildings Survey J. Alexander, Photographer August 1968 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey J. Alexander, Photographer August 1968 SECOND FLOOR PARLOR LOOKING NORTHWEST - Andrew Ross Tenant House II, 1210 Thirtieth Street Northwest, Washington, District of Columbia, DC

  20. Alexander F. Chamberlain: a life's work.

    PubMed

    Berkman, Julia M

    2005-01-01

    This article examines the life and work of Alexander Francis Chamberlain. Though he has received little attention since the early 1900s, the importance of this scholar should not be underestimated. Chamberlain made notable contributions to the body of knowledge in anthropology-a discipline that, at the time, was a combination of anthropological and psychological inquiry. His early work began with investigations into the cultures and languages of two Indian tribes indigenous to Canada and the northern United States and, within a few decades, positioned Chamberlain as the leading scholar in this domain. Beyond his ethnographic insights, Chamberlain queried the development of the child and wrote on the subject of childhood in world folklore. He concerned himself with a scope of worthwhile subjects ranging from linguistics to women's suffrage. No topic was out of range as all forms of human study addressed the need for seeing each group as a contributing force to humanity at large. Chamberlain emphasized that no single racial, ethnic, or religious group should be singled out as inherently superior to another, a belief far ahead of his time. This article is an attempt at drawing a picture of a man whose scholarly achievements and strength of character are captured in the depth and breadth of his writing. PMID:17549937

  1. Alexander F. Chamberlain: a life's work.

    PubMed

    Berkman, Julia M

    2005-01-01

    This article examines the life and work of Alexander Francis Chamberlain. Though he has received little attention since the early 1900s, the importance of this scholar should not be underestimated. Chamberlain made notable contributions to the body of knowledge in anthropology-a discipline that, at the time, was a combination of anthropological and psychological inquiry. His early work began with investigations into the cultures and languages of two Indian tribes indigenous to Canada and the northern United States and, within a few decades, positioned Chamberlain as the leading scholar in this domain. Beyond his ethnographic insights, Chamberlain queried the development of the child and wrote on the subject of childhood in world folklore. He concerned himself with a scope of worthwhile subjects ranging from linguistics to women's suffrage. No topic was out of range as all forms of human study addressed the need for seeing each group as a contributing force to humanity at large. Chamberlain emphasized that no single racial, ethnic, or religious group should be singled out as inherently superior to another, a belief far ahead of his time. This article is an attempt at drawing a picture of a man whose scholarly achievements and strength of character are captured in the depth and breadth of his writing.

  2. Alexander disease: a review and the gene.

    PubMed

    Johnson, Anne B

    2002-01-01

    This review presents historical and clinical information on the rare human brain disorder known as Alexander disease (ALX), and reports on the recent discovery of the gene that appears to be causative. The disease is a fatal, white matter disorder (leukodystrophy) of childhood. Adult onset cases also have been described, but it has not been clear whether they represent the same disease. Until recently the diagnosis was made by the pathological examination of brain tissue, in which abundant Rosenthal fibers were found. These abnormal structures occurred within astrocytes, but their composition was unclear. In 1985, a child underwent a diagnostic brain biopsy at this institution, which established the diagnosis of ALX. Ultrastructural immunocytochemistry revealed that the Rosenthal fibers contained abundant amounts of glial fibrillary acidic protein (GFAP), a normal component of astocytic intermediate filaments. Thus, the gene for this filament protein was considered a candidate gene for the cause of ALX, and DNA samples from children presumed or proven to have this disorder were banked for future study. Other work on the same brain biopsy showed that Rosenthal fibers also contained abundant alphaB-crystallin, a heat shock protein, but no defect was found in its gene. A decade after the biopsy, a transgenic mouse with an extra copy of the gene for GFAP was produced. These mice died early and their brains contained Rosenthal fibers. Although not an exact model for ALX, this also suggested that the gene for GFAP should be considered a candidate gene for ALX. Subsequent research has demonstrated that the great majority of childhood ALX cases contain mutations in the gene for GFAP. This work is now being extended as a diagnostic test, as well as to seek understanding of the pathogenesis of ALX and possible approaches for treatment.

  3. Zanvil Alexander Cohn 1926-1993

    PubMed Central

    1994-01-01

    Zanvil Alexander Cohn, an editor of this Journal since 1973, died suddenly on June 28, 1993. Cohn is best known as the father of the current era of macrophage biology. Many of his scientific accomplishments are recounted here, beginning with seminal studies on the granules of phagocytes that were performed with his close colleague and former editor of this Journal, James Hirsch. Cohn and Hirsch identified the granules as lysosomes that discharged their contents of digestive enzymes into vacuoles containing phagocytosed microbes. These findings were part of the formative era of cell biology and initiated the modern study of endocytosis and cell-mediated resistance to infection. Cohn further explored the endocytic apparatus in pioneering studies of the mouse peritoneal macrophage in culture. He described vesicular inputs from the cell surface and Golgi apparatus and documented the thoroughness of substrate digestion within lysosomal vacuoles that would only permit the egress of monosaccharides and amino acids. These discoveries created a vigorous environment for graduate students, postdoctoral fellows, and junior and visiting faculty. Some of the major findings that emerged from Cohn's collaborations included the radioiodination of the plasma membrane for studies of composition and turnover; membrane recycling during endocytosis; the origin of the mononuclear phagocyte system in situ; the discovery of the dendritic cell system of antigen-presenting cells; the macrophage as a secretory cell, including the release of proteases and large amounts of prostaglandins and leukotrienes; several defined parameters of macrophage activation, especially the ability of T cell-derived lymphokines to enhance killing of tumor cells and intracellular protozoa; the granule discharge mechanism whereby cytotoxic lymphocytes release the pore-forming protein perforin; the signaling of macrophages via myristoylated substrates of protein kinase C; and a tissue culture model in which

  4. Did Alexander the Great die of acute pancreatitis?

    PubMed

    Sbarounis, C N

    1997-06-01

    I propose that Alexander the Great died of acute pancreatitis secondary to heavy alcohol consumption and a very rich meal. The cause of death of prominent historic or artistic figures attracts considerable interest of historians and researchers. This is especially the case for Alexander the Great. More than 20,000 publications, books, or monographs on the life and work of Alexander the Great have been published. There are several theories and hypotheses regarding the cause of his death, that are based on historic descriptions, diaries, notations, and interpretations of events. It is inevitable that history and myth intermingle in any investigative approach, no matter how scholarly. In this article, on the basis of several historic sources. I have made an effort to reconstruct the final 14 days of his life and record the course of medical events that preceded his death with the formulation of a plausible diagnosis.

  5. Alexander the Great and West Nile virus encephalitis.

    PubMed

    Marr, John S; Calisher, Charles H

    2003-12-01

    Alexander the Great died in Babylon in 323 BC. His death at age 32 followed a 2-week febrile illness. Speculated causes of death have included poisoning; assassination, and a number of infectious diseases. One incident, mentioned by Plutarch but not considered by previous investigators, may shed light on the cause of Alexander's death. The incident, which occurred as he entered Babylon, involved a flock of ravens exhibiting unusual behavior and subsequently dying at his feet. The inexplicable behavior of ravens is reminiscent of avian illness and death weeks before the first human cases of West Nile virus infection were identified in the United States. We posit that Alexander may have died of West Nile virus encephalitis.

  6. Obituary: Donald Alexander Macrae, 1916-2006

    NASA Astrophysics Data System (ADS)

    Seaquist, E. R.

    2007-12-01

    With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

  7. Sir Alexander Fleming: Scottish researcher who discovered penicillin.

    PubMed

    Ligon, B Lee

    2004-01-01

    The discovery and development of penicillin changed the entire direction of approaches to treating infectious diseases and saved the lives of millions of people. Indeed, the development of penicillin was a watershed event in the battle against infectious diseases, and the individual who discovered it, Sir Alexander Fleming, remains a prominent individual in the annals of medical history. This article focuses primarily on the personal life of Alexander Fleming, an individual who had a remarkable diversity of interests and who made many contributions to science and medicine.

  8. 8. View of southwest rear and southeast side of AlexanderAlmon ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. View of southwest rear and southeast side of Alexander-Almon House with cement block outbuilding to far left, facing north. - Alexander-Almon House, 130 Philip Almon Road, Roopville, Carroll County, GA

  9. 12. Detail view of southeast side window of AlexanderAlmon House ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Detail view of southeast side window of Alexander-Almon House with rain barrel at lower left and roof rafter tails at top, facing northwest. - Alexander-Almon House, 130 Philip Almon Road, Roopville, Carroll County, GA

  10. Obituary: Walter Alexander Feibelman, 1930-2004

    NASA Astrophysics Data System (ADS)

    Oergerle, William

    2005-12-01

    Walter Alexander Feibelman, 79, an astronomer who discovered the E-ring of Saturn, died of a heart attack 19 November 2004 at his home at Riderwood Village in Silver Spring, Maryland. Walter was born 30 October 1925 in Berlin, Germany to Bernard and Dora Feibelman. He came to the United States with his parents in 1941. They were some of the last German Jews to flee Nazi Germany. Years later, he reported his experiences in an account contributed to the U.S. Holocaust Memorial Museum. As a youth, he worked at a cleaning shop and as a soda jerk before taking a course in tool and die making. He worked at the Abbey Photo Corp. in New York and in a model-making firm, where he constructed models of aircraft for use in identification courses by the Army Air Forces. After high school, he attended the Carnegie Institute of Technology and received his BS degree in 1956. Until 1969, he was a research scientist at the University of Pittsburgh. While working as an assistant research professor in physics and astronomy at the University of Pittsburgh in 1967, he examined a photo of Saturn taken a year earlier at the university's Allegheny Observatory. The E-ring -- unlike the bright main rings, A, B, C, D and F -- is faint and not easily spotted. He paired his observation with calculations and announced his discovery, which remained unconfirmed until the Pioneer 11 flyby in 1979. Walter joined the Optical Astronomy Division of Goddard Space Flight Center in Greenbelt in 1969, and worked there until 2002, when he became an emeritus astronomer at NASA. He became associated with the International Ultraviolet Explorer project, and worked on developing detectors for the orbiting observatory's spectrograph. The project turned out to be one of NASA's most successful observatories, operating from 1978 to 1996. In his scientific career, he published more than 200 refereed articles, mainly on hot stars and planetary nebulae. He also wrote papers in the fields of photography, spectroscopy

  11. Obituary: Donald Alexander Macrae, 1916-2006

    NASA Astrophysics Data System (ADS)

    Seaquist, E. R.

    2007-12-01

    With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

  12. Alexander the Great, the dahlia, and the tortoise.

    PubMed

    Macmillan, Malcolm

    2004-06-01

    Some of the problems of establishing the cause of the death of Alexander the Great are like the attempts to find causes other than hysteria for Anna O.'s symptoms. The more general problem of using plausibility as a criterion of the truth of such reconstructions are illustrated by the arguments embedded in Tom Stoppard's Arcadia.

  13. 46. Photocopy of photograph (Pentran file), (from Alexander Brown's Peninsula's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Photocopy of photograph (Pentran file), (from Alexander Brown's Peninsula's Last Street Cars, Daily Press, January 15, 1956) photographer unknown. The first streetcar (with dignitaries) to make the run from Newport News to a new housing development named Hilton Village in September 1918. - Newport News & Old Point Railway & Electric Company, Trolley Barn & Administration Building, 3400 Victoria Boulevard, Hampton, Hampton, VA

  14. Teaching Nuclear Radiation and the Poisoning of Alexander Litvinenko

    ERIC Educational Resources Information Center

    David R. Lapp

    2008-01-01

    The recent international story about the death of the former KGB agent Alexander Litvinenko has more than just a few wondering about radiation poisoning and the sinister sounding polonium-210. I was preparing to begin a nuclear radiation unit the Monday after Thanksgiving 2006. As it turned out, Litvinenko died Thanksgiving Day after a short and…

  15. Alexander Meiklejohn in Search of Freedom and Dignity.

    ERIC Educational Resources Information Center

    Johnson, Tony W.

    1982-01-01

    Assesses the contributions of the philosopher/educator Alexander Meiklejohn. Discusses the influences of Jean-Jacques Rousseau, Immanuel Kant, and the U.S. Constitution on Meiklejohn's educational theories, which stressed that human freedom and dignity can be enhanced by rigorous examination of U.S. Supreme Court decisions and the meaning of…

  16. Alexander the Great, the dahlia, and the tortoise.

    PubMed

    Macmillan, Malcolm

    2004-06-01

    Some of the problems of establishing the cause of the death of Alexander the Great are like the attempts to find causes other than hysteria for Anna O.'s symptoms. The more general problem of using plausibility as a criterion of the truth of such reconstructions are illustrated by the arguments embedded in Tom Stoppard's Arcadia. PMID:15370321

  17. The Century-Old Wisdom of Alexander Graham Bell.

    ERIC Educational Resources Information Center

    Cornett, Orin

    1990-01-01

    This article reflects on Alexander Graham Bell's 1888 testimony before the Royal Commission of the United Kingdom on the Condition of the Deaf and Dumb, Etc. Excerpts are grouped by reference to (1) language education for the hearing impaired; (2) speechreading; (3) methods of teaching; (4) speech; and (5) sign language. (Author/PB)

  18. View west of the James and Lucy Alexander gravestone and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View west of the James and Lucy Alexander gravestone and family plot among other demarcated family plots in the Female Union Band Cemetery. - Mount Zion Cemetery/ Female Union Band Cemetery, Bounded by 27th Street right-of-way N.W. (formerly Lyons Mill Road), Q Street N.W., & Mill Road N.W., Washington, District of Columbia, DC

  19. A complex-network perspective on Alexander's wholeness

    NASA Astrophysics Data System (ADS)

    Jiang, Bin

    2016-12-01

    The wholeness, conceived and developed by Christopher Alexander, is what exists to some degree or other in space and matter, and can be described by precise mathematical language. However, it remains somehow mysterious and elusive, and therefore hard to grasp. This paper develops a complex network perspective on the wholeness to better understand the nature of order or beauty for sustainable design. I bring together a set of complexity-science subjects such as complex networks, fractal geometry, and in particular underlying scaling hierarchy derived by head/tail breaks - a classification scheme and a visualization tool for data with a heavy-tailed distribution, in order to make Alexander's profound thoughts more accessible to design practitioners and complexity-science researchers. Through several case studies (some of which Alexander studied), I demonstrate that the complex-network perspective helps reduce the mystery of wholeness and brings new insights to Alexander's thoughts on the concept of wholeness or objective beauty that exists in fine and deep structure. The complex-network perspective enables us to see things in their wholeness, and to better understand how the kind of structural beauty emerges from local actions guided by the 15 fundamental properties, and in particular by differentiation and adaptation processes. The wholeness goes beyond current complex network theory towards design or creation of living structures.

  20. A Darwinian mystery: fluctuations in runoff from the la Plata basin (Alexander von Humboldt Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Clarke, R. T.

    2012-04-01

    During the voyage of HMS Beagle, Charles Darwin sailed in a small boat along the River Paraná, a major tributary of the la Plata drainage system. He wrote about the occurrence of severe droughts (the latest of which had been termed the "gran seco") alternating with periods of severe flooding. From reports received, he concluded that these events appeared to be cyclic with a period "of about fifteen years". Because extended periods of low flow in Brazilian rivers are of immense economic importance, the presentation describes a search for the material which led Darwin to this conclusion. A prolonged period of low flow in another la Plata tributary - the River Paraguay - not unlike the "gran seco" reported by Darwin, has occurred more recently; if such low flows were to recur in the future, the consequences would be severe for a region where more than 70% of energy is supplied by hydropower. A priori considerations suggest the use of statistical long-memory models for predicting River Paraguay water-levels, and some preliminary results from their use are presented.

  1. Brain and aviation: on the 80th anniversary of Constantin von Economo's (1876-1931) death.

    PubMed

    Sak, Jarosław; Grzybowski, Andrzej

    2013-03-01

    2011 marks the 80th anniversary of the death of Constantin Alexander von Economo who conducted advanced research on the cytoarchitectonics of the brain. This Austrian neurologist and the pioneer of aviation described encephalitis lethargica, discovered the spindle neurons, and postulated the existence of the sleep and wakefulness centre in the brain. What is more he realized two of the biggest dreams of humankind: conquering space and getting to know the secrets of the human brain.

  2. Alexander disease: a leukodystrophy caused by a mutation in GFAP.

    PubMed

    Johnson, Anne B

    2004-05-01

    Alexander disease, a rare fatal disorder of the central nervous system, causes progressive loss of motor and mental function. Until recently it was of unknown etiology, almost all cases were sporadic, and there was no effective treatment. It was most common in an infantile form, somewhat less so in a juvenile form, and was rarely seen in an adult-onset form. A number of investigators have now shown that almost all cases of Alexander disease have a dominant mutation in one allele of the gene for glial fibrillary acidic protein (GFAP) that causes replacement of one amino acid for another. Only in very rare cases of the adult-onset form is the mutation present in either parent. Thus, in almost all cases, the mutation arises as a spontaneous event, possibly in the germ cell of one parent.

  3. Alexander the Great's Tomb at Siwa: The Astronomical Orientation

    NASA Astrophysics Data System (ADS)

    Papathanassiou, M.; Souvaltzis, Em.; Souvaltzi, L.; Moussas, X.

    A preliminary report on the possible astronomical orientation of the Tomb of Alexander the Great, recently found and excavated by the greek archaeologist Liana Souvaltzi. The tomb is a greek building of doric style. Its enormous dimensions make it the largest amongst the found macedonian tombs (much bigger than the tomb of Philip II, Alexander's father). The tomb faces generally south---west and its orientation could be related either to the constellation of Centaurus or to the star Canopus. The walls of the two long sides of the building have strickingly different widhts. Moreover each wall has three doors (opposite in pairs) of slightly different sizes. We examine the possibility the openings of the doors and their assymetries to be designed and constructed according to some astronomical (solar or stellar) orientations.

  4. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease

    PubMed Central

    Wang, Liqun; Hagemann, Tracy L.; Kalwa, Hermann; Michel, Thomas; Messing, Albee; Feany, Mel B.

    2015-01-01

    Glia play critical roles in maintaining the structure and function of the nervous system; however, the specific contribution that astroglia make to neurodegeneration in human disease states remains largely undefined. Here we use Alexander disease, a serious degenerative neurological disorder caused by astrocyte dysfunction, to identify glial-derived NO as a signalling molecule triggering astrocyte-mediated neuronal degeneration. We further find that NO acts through cGMP signalling in neurons to promote cell death. Glial cells themselves also degenerate, via the DNA damage response and p53. Our findings thus define a specific mechanism for glial-induced non-cell autonomous neuronal cell death, and identify a potential therapeutic target for reducing cellular toxicity in Alexander disease, and possibly other neurodegenerative disorders with glial dysfunction. PMID:26608817

  5. Alexander's law during high-acceleration head rotations in humans.

    PubMed

    Anagnostou, Evangelos; Heimberger, Joachim; Sklavos, Sokratis; Anastasopoulos, Dimitri

    2011-03-30

    Alexander's law states that the amplitude of the spontaneous nystagmus grows with increasing gaze in the direction of the fast phase. Using the search-coil method we employed head impulses at various eye-in-orbit azimuth angles to test (i) whether the normal vestibulo-ocular reflex (VOR) in the behaviorally relevant high-frequency range has intrinsic properties that could account for Alexander's law and (ii) whether such properties can also be shown in patients with unilateral vestibulopathy. We showed that the gain of the VOR remained unaffected by eye-in-orbit position in contols and in patients, both on ipsilesional and contralesional stimuli. These findings suggest that eye-in-orbit position does not directly modulate the activity in VOR pathways, neither during unbalanced but reciprocal (in controls), nor during unbalanced and nonreciprocal natural vestibular stimulation (in patients).

  6. Alexander the Great and West Nile Virus Encephalitis

    PubMed Central

    Marr, John S.

    2003-01-01

    Alexander the Great died in Babylon in 323 BC. His death at age 32 followed a 2-week febrile illness. Speculated causes of death have included poisoning, assassination, and a number of infectious diseases. One incident, mentioned by Plutarch but not considered by previous investigators, may shed light on the cause of Alexander’s death. The incident, which occurred as he entered Babylon, involved a flock of ravens exhibiting unusual behavior and subsequently dying at his feet. The inexplicable behavior of ravens is reminiscent of avian illness and death weeks before the first human cases of West Nile virus infection were identified in the United States. We posit that Alexander may have died of West Nile encephalitis. PMID:14725285

  7. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease.

    PubMed

    Wang, Liqun; Hagemann, Tracy L; Kalwa, Hermann; Michel, Thomas; Messing, Albee; Feany, Mel B

    2015-01-01

    Glia play critical roles in maintaining the structure and function of the nervous system; however, the specific contribution that astroglia make to neurodegeneration in human disease states remains largely undefined. Here we use Alexander disease, a serious degenerative neurological disorder caused by astrocyte dysfunction, to identify glial-derived NO as a signalling molecule triggering astrocyte-mediated neuronal degeneration. We further find that NO acts through cGMP signalling in neurons to promote cell death. Glial cells themselves also degenerate, via the DNA damage response and p53. Our findings thus define a specific mechanism for glial-induced non-cell autonomous neuronal cell death, and identify a potential therapeutic target for reducing cellular toxicity in Alexander disease, and possibly other neurodegenerative disorders with glial dysfunction. PMID:26608817

  8. Dr Alexander Graham Bell--audiologist and speech therapist.

    PubMed

    Chakravorty, R C

    1976-09-01

    Alexander Graham Bell is best known for his role in the invention of the telephone. However, he had a lifelong involvement in speech therapy and audiology besides many other medical investigations. He was also awarded an honorary MD degree from Heidelberg University. In this, the 100th anniversary of his invention of the telephone, his life and some of his medical interests are briefly reviewed. PMID:786234

  9. Dr Alexander Graham Bell--audiologist and speech therapist.

    PubMed

    Chakravorty, R C

    1976-09-01

    Alexander Graham Bell is best known for his role in the invention of the telephone. However, he had a lifelong involvement in speech therapy and audiology besides many other medical investigations. He was also awarded an honorary MD degree from Heidelberg University. In this, the 100th anniversary of his invention of the telephone, his life and some of his medical interests are briefly reviewed.

  10. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher von Braun with Dr. Eberhard Rees and R.W. Cook at a press conference concerning Dr. Von Braun's assignment to NASA headquarters and Dr. Rees' subsequent assignment as Marshall Center director.

  11. The 'horns' of a medical dilemma: Alexander the Great.

    PubMed

    Russell, Gül A

    2004-06-01

    Retrospective 'diagnosis' of clinical disorders of famous historical figures has been of medical interest. In the absence of a patient's 'body', the validity of 'physical symptoms' and their interpretation by contemporary diagnostic criteria are questionable. When the symptoms have been gleaned from the patients's effigy which, as in the case of Alexander the Great, is submerged in legend, the enterprise becomes inherently hazardous. In the present paper, some of the conceptual problems underlying retrospective diagnoses will be identified. Then the use of iconographic records, such as numismatics and sculpture, to provide evidence of clinical symptoms will be shown to be highly misleading.

  12. Alexander disease - astrogliopathy considered as leukodystrophy - experience of an institution.

    PubMed

    Mierzewska, Hanna; Mierzewska-Schmidt, Magdalena; Salomons, Gajja S; Dudzińska, Magdalena; Szczepanik, Elżbieta

    2016-01-01

    Alexander Disease (ALXDRD) is an autosomal dominant leukodystrophy caused by mutation in one allele of GFAP gene, encoding glial fibrillary acidic protein (GFAP). Most cases occur due to de novo. There are three clinical subtypes of ALXDRD: infantile, juvenile and adult form, but congenital form is also outlined. The disease's spectrum comprises of macrocephaly, progressive pyramidal signs, and seizures in congenital and infantile subtypes. Neuropathologically are enormous number of Rosenthal fibers (RF) mainly around vessels, in subependymal and subpial regions are found. The diagnosis is based on the typical findings on MRI: diffuse white mater lesions with frontal regions preponderance and possibly on the detection of the gene mutation. Here we present six Polish children affected of Alexander disease with congenital (1), infantile (4) and juvenile (1) form. Five of them were previously misdiagnosed as cerebral palsy or unspecific developmental delay; two patients had MRI because of another suspicion, before specific diagnosis was established. Molecular analysis performed in four cases confirmed mutations of GFAP gene; all mutation were de novo. The role of astroglia in brain is shortly reviewed. PMID:27442695

  13. [Alexander Borodin--physician, chemist, scientist, teacher and composer].

    PubMed

    Vik, T

    1998-12-10

    Concert programmes and CD covers suggest that the Russian composer Alexander Borodin (1833-87) was also a great scientist. In this article we examine this proposition. Borodin was born in St. Petersburg as the illegitimate son of a Russian nobleman. As a boy his talents ranged from music to chemistry and languages. Borodin studied medicine at the Medico-Surgical Academy in St. Petersburg from 1850 to 1855 and defended his doctoral thesis on the similarity between arsenic and phosphoric acid in 1858. He did not, however, feel comfortable in his role as a doctor, and soon started to work as a chemist. In 1864 he was appointed professor of chemistry at the Medico-Surgical Academy. In 1861, Borodin attended the first international congress of chemistry in Karlsruhe, and he was among the founders of the Russian Chemical Society in 1868. He published 42 articles and was a friend of Dmitri Mendeleev, the scientist who described the periodic system. In 1872, Borodin started the first medical courses for women in Russia. It seems warranted to conclude that Alexander Borodin was indeed a great scientist and university teacher, though his immortality was earned by his leisure time activities. PMID:9914755

  14. [Alexander Borodin--physician, chemist, scientist, teacher and composer].

    PubMed

    Vik, T

    1998-12-10

    Concert programmes and CD covers suggest that the Russian composer Alexander Borodin (1833-87) was also a great scientist. In this article we examine this proposition. Borodin was born in St. Petersburg as the illegitimate son of a Russian nobleman. As a boy his talents ranged from music to chemistry and languages. Borodin studied medicine at the Medico-Surgical Academy in St. Petersburg from 1850 to 1855 and defended his doctoral thesis on the similarity between arsenic and phosphoric acid in 1858. He did not, however, feel comfortable in his role as a doctor, and soon started to work as a chemist. In 1864 he was appointed professor of chemistry at the Medico-Surgical Academy. In 1861, Borodin attended the first international congress of chemistry in Karlsruhe, and he was among the founders of the Russian Chemical Society in 1868. He published 42 articles and was a friend of Dmitri Mendeleev, the scientist who described the periodic system. In 1872, Borodin started the first medical courses for women in Russia. It seems warranted to conclude that Alexander Borodin was indeed a great scientist and university teacher, though his immortality was earned by his leisure time activities.

  15. 33 CFR 162.250 - Port Alexander, Alaska; speed of vessels.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Port Alexander, Alaska; speed of... Alexander, Alaska; speed of vessels. (a) Definition. The term “Port Alexander” includes the entire inlet from its head to its entrance from Chatham Strait. (b) Speed. The speed of all vessels of 5 tons...

  16. 33 CFR 162.250 - Port Alexander, Alaska; speed of vessels.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Port Alexander, Alaska; speed of... Alexander, Alaska; speed of vessels. (a) Definition. The term “Port Alexander” includes the entire inlet from its head to its entrance from Chatham Strait. (b) Speed. The speed of all vessels of 5 tons...

  17. 33 CFR 162.250 - Port Alexander, Alaska; speed of vessels.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Port Alexander, Alaska; speed of... Alexander, Alaska; speed of vessels. (a) Definition. The term “Port Alexander” includes the entire inlet from its head to its entrance from Chatham Strait. (b) Speed. The speed of all vessels of 5 tons...

  18. 33 CFR 162.250 - Port Alexander, Alaska; speed of vessels.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Port Alexander, Alaska; speed of... Alexander, Alaska; speed of vessels. (a) Definition. The term “Port Alexander” includes the entire inlet from its head to its entrance from Chatham Strait. (b) Speed. The speed of all vessels of 5 tons...

  19. 33 CFR 162.250 - Port Alexander, Alaska; speed of vessels.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Port Alexander, Alaska; speed of... Alexander, Alaska; speed of vessels. (a) Definition. The term “Port Alexander” includes the entire inlet from its head to its entrance from Chatham Strait. (b) Speed. The speed of all vessels of 5 tons...

  20. The death of Alexander the Great--a spinal twist of fate.

    PubMed

    Ashrafian, Hutan

    2004-06-01

    Alexander the Great died in 323 B.C. from an unknown cause. Physical depictions of this historical figure reveal the likelihood of a cervical scoliotic deformity. This is substantiated with the medical history and is correlated with his untimely death. For the first time, it is concluded that Alexander's death may have ensued from the sequelae of congenital scoliotic syndrome.

  1. Alexander's (356-323 BC) expeditionary Medical Corps 334-323 BC.

    PubMed

    Retsas, Spyros

    2009-08-01

    Alexander had a profound interest in medicine and healing. Original Greek texts survive mainly from the works of Plutarch and Arrian. This paper examines original sources naming the physicians who participated in Alexander's expedition in Asia, the battle injuries he sustained and his final illness in Babylon.

  2. Kinesthetic Ventures Informed by the Work of F. M. Alexander, Stanislavski, Peirce, and Freud.

    ERIC Educational Resources Information Center

    Bouchard, Ed; Wright, Ben; Protzel, Michael, Ed.

    This book is about education harvested from self-observation. F. Matthias Alexander (1869-1955) studied the experience of self formation, working with motor habits. His method is used in performing arts training to enhance bodily and vocal expression. Like Alexander, Konstantine Stanislavski (1863-1938) and Sigmund Freud (1856-1939) studied human…

  3. 76 FR 28226 - Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander; and AIR 7 Seas... ``Complainant,'' against African Shipping; Njoroge Muhia, ALCO Logistics, LLC; Brenda Alexander; and Air 7 Seas Transport Logistics, Inc.; hereinafter ``Respondents''. Complainant asserts that she is acting agent...

  4. The Astronomer Alexander I. Postoiev (1900-1976)

    NASA Astrophysics Data System (ADS)

    Dos Santos, P. M.; Matsuura, O. T.

    This is a biographical note on the life of Dr Alexander I. Postoiev, a victim of Stalin's purge of Soviet astronomers in 1936-1937 (McCutcheon, 1985). Along with his family, he left the Soviet Union in 1943, and lived in Germany as a refugee and "displaced person" until 1952, when he moved to Brazil. Then he started the second part of his professional career. Thanks to his efforts the Astronomical and Geophysical Institute (IAG) from the University of Sao Paulo (USP) was involved, for the first time, in programme of international cooperation, thus contributing to the institutional consolidation of IAG/USP as a leading centre of astronomical research and teaching today in Brazil.

  5. Silurian Gastropoda from the Alexander terrane, southeast Alaska

    USGS Publications Warehouse

    Rohr, D.M.; Blodgett, R.B.

    2008-01-01

    Gastropods are described from Ludlow-age strata of the Heceta Limestone on Prince of Wales Island, southeast Alaska. They are part of a diverse megabenthic fauna of the Alexander terrane, an accreted terrane of Siberian or Uralian affinities. Heceta Limestone gastropods with Uralian affinities include Kirkospira glacialis, which closely resembles "Pleurotomaria" lindstromi Oehlert of Chernyshev, 1893, Retispira cf. R. volgulica (Chernyshev, 1893), and Medfracaulus turriformis (Chernyshev, 1893). Medfracaulus and similar morphotypes such as Coelocaulus karlae are unknown from rocks that are unquestionably part of the North American continent (Laurentia) during Late Silurian time. Beraunia is previously known only from the Silurian of Bohemia. Pachystrophia has previously been reported only from western North American terranes (Eastern Klamath, York, and Farewell terranes) and Europe. Bathmopterus Kirk, 1928, is resurrected and is only known from the Silurian of southeast Alaska. Newly described taxa include Hecetastoma gehrelsi n. gen. and n. sp. and Baichtalia tongassensis n. gen. and n. sp. ??2008 The Geological Society of America.

  6. Alexander the Great's tombolos at Tyre and Alexandria, eastern Mediterranean

    NASA Astrophysics Data System (ADS)

    Marriner, N.; Goiran, J. P.; Morhange, C.

    2008-08-01

    Tyre and Alexandria's coastlines are today characterised by wave-dominated tombolos, peculiar sand isthmuses that link former islands to the adjacent continent. Paradoxically, despite a long history of inquiry into spit and barrier formation, understanding of the dynamics and sedimentary history of tombolos over the Holocene timescale is poor. At Tyre and Alexandria we demonstrate that these rare coastal features are the heritage of a long history of natural morphodynamic forcing and human impacts. In 332 BC, following a protracted seven-month siege of the city, Alexander the Great's engineers cleverly exploited a shallow sublittoral sand bank to seize the island fortress; Tyre's causeway served as a prototype for Alexandria's Heptastadium built a few months later. We report stratigraphic and geomorphological data from the two sand spits, proposing a chronostratigraphic model of tombolo evolution.

  7. Teaching Nuclear Radiation and the Poisoning of Alexander Litvinenko

    NASA Astrophysics Data System (ADS)

    Lapp, David R.

    2008-03-01

    The recent international story about the death of the former KGB agent Alexander Litvinenko has more than just a few wondering about radiation poisoning and the sinister sounding polonium-210. I was preparing to begin a nuclear radiation unit the Monday after Thanksgiving 2006. As it turned out, Litvinenko died Thanksgiving Day after a short and terrible three-week illness. Having the story continue to unfold throughout the next two weeks of the new unit provided a daily opportunity for students to see the relevance of what we were doing in class. My students were able to have meaningful and informed conversations with their peers and parents over an important international event. They even began to feel a bit like authorities themselves when listening to experts respond to media questions about polonium-210 and nuclear radiation in general. This paper discusses some of the ways that the story of Litvinenko was used while presenting the topic of nuclear radiation.

  8. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left) and Fred W. Kelley examine a ST-100 Stellar Instrument Platform in the astrionics lab. Dr. Von Braun, then deputy associate administrator for planning, NASA, was visiting on the anniversary of the establishment of the Marshall Space Flight Center.

  9. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher Von Braun, stands in front of a Saturn IB Launch Vehicle at Kennedy Space Center (KSC). Dr. Von Braun was Marshall's first Center Director (1960-1970). Under his leadership Marshall was responsible for the development of the Saturn rockets, the Skylab project and getting the United States into Space and landing on the moon with the Apollo missions.

  10. Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

  11. Effects of Alexander Technique training experience on gait behavior in older adults.

    PubMed

    O'Neill, Matthew M; Anderson, David I; Allen, Diane D; Ross, Christopher; Hamel, Kate A

    2015-07-01

    Heightened fall risk, potentially caused by aging-related changes in gait, is a serious health issue faced by older adults. The Alexander Technique is thought to improve balance and motor function; however, the technique's effect on gait has not been studied. The purpose of this study was to examine the effect of Alexander Technique training in older adults on the temporospatial characteristics of gait and medio-lateral center of mass displacement during fast and comfortably paced over-ground walking. Six licensed Alexander Technique teachers and seven controls between the ages of 60 and 75 years of age participated in the study. Alexander Technique teachers exhibited a reduction in medio-lateral center of mass displacement during fast paced walking compared to comfortably paced walking that was not present in controls. Due to this difference Alexander Technique teachers displayed a smaller medio-lateral Center of Mass displacement compared to controls during fast paced walking. Alexander Technique teachers also demonstrated significantly smaller stride width and lower gait timing variability compared to controls. These findings, which suggest superior control of dynamic stability during gait and potentially reduced fall risk in Alexander Technique teachers, warrant further study.

  12. The modern mythology of the left-handedness of Alexander the Great.

    PubMed

    McManus, I C

    2006-11-01

    The prevalent modern suggestion that Alexander the Great was left-handed probably derives from Michael Barsley's (1966) book, Left-handed man is a right-handed word, perhaps by mutation from as earlier story cited by Wile in 1934 from a 17th century Rabbirical exegesis, which said that Alexander discovered a country where all the inhabitants were left-handed. That itself may derive in part from the medieval Hebrew Book of Jossippon, which mentions Alexander talking of the superiority of the left hand and of how "kings stemming from the tribe of kings are left-handed".

  13. The efficacy of medicine during the campaigns of Alexander the Great.

    PubMed

    Ruffin, J R

    1992-09-01

    This paper examines the various factors that may have determined the efficacy of physicians during the campaigns of Alexander the Great. Such general variables as the adequacy of preparation, the nature of the medical profession, and the extent of preventative measures are all discussed at the outset of the paper, followed by a more detailed examination of the specific wounds, illnesses, and treatments of Alexander as described in the accounts of the Alexander historians Plutarch, Curtius, and Arrian. Where no remedy is given by these writers (as is usually the case), this paper speculates on the efficacy of possible treatments as advocated in the contemporary Hippocratic corpus. Casualty statistics of the campaigns are compared to a similar review of Homer's Iliad. From these examinations, this paper concludes that wound treatment efficacy was significantly greater than that of illness treatment, and that Alexander lost many more men to disease than to the wounds of war.

  14. The Berlin tradition in Chicago: Franz Alexander and the Chicago Institute for Psychoanalysis.

    PubMed

    Schmidt, Erika S

    2010-01-01

    Freud considered Franz Alexander, the first graduate of the Berlin Psychoanalytic Institute and an assistant in the Berlin Polyclinic, to be "one of our strongest hopes for the future." Alexander went on to become the first director of the Chicago Institute for Psychoanalysis in 1932 and modeled some of the Chicago Institute's mission on his Berlin experiences. He was also a researcher in psychosomatic medicine, a prolific writer about psychoanalysis and prominent in psychoanalytic organizations. As he proposed modifications in psychoanalytic technique, he became a controversial figure, especially in the elaboration of his ideas about brief therapy and the corrective emotional experience. This paper puts Alexander's achievements in historical context, draws connections between the Berlin and Chicago Institutes and suggests that, despite his quarrels with traditional psychoanalysis, Alexander's legacy may be in his attitude towards psychoanalysis, characterized by a commitment to scientific study, a willingness to experiment, and a conviction about the role of psychoanalysis within the larger culture.

  15. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the astronautics lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics lab.

  16. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for Planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the Astronautics Lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics Lab.

  17. Expedition 8 Crew Interviews: Alexander Y. Kaleri - FE

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Russian cosmonaut Alexander Y. Kaleri, Flight Engineer on Expedition 8 to the International Space Station (ISS), answers interview questions on this video, either himself or with the help of an interpreter. The questions cover: 1) The goal of the expedition; 2) The place in history of Mir; 3) The reaction to the loss of Columbia in Houston; 4) Why the rewards of spaceflight are worth the risks; 5) Why he decided to become a cosmonaut; 6) His memory of Yuri Gagarin's first flight; 7) What happens on a Soyuz capsule during launch and flight; 8) Are Soyuz maneuvers automatic or manual; 8) How the ISS science mission will be advanced during his stay; 9) The responsibilities of a Flight Engineer onboard the ISS; 10) Extravehicular activity (EVA) plans at that time; 11) The Shuttle Return to Flight and his preference for a Shuttle or Soyuz landing; 12) Why the last Soyuz landing was too rough; 13) The most valueable contribution of the ISS program.

  18. What is the alternative to the Alexander-Orbach relation?

    NASA Astrophysics Data System (ADS)

    Sokolov, Igor M.

    2016-03-01

    The Alexander-Orbach (AO) relation d w = 2d f /d s connecting the fractal dimension of a random walk’s (RW) trajectory d w or the exponent of anomalous diffusion α = 2/d w on a fractal structure with the fractal and spectral dimension of the structure itself plays a key role in discussion of dynamical properties of complex systems including living cells and single biomolecules. This relation however does not hold universally and breaks down for some structures like diffusion limited aggregates and Eden trees. We show that the alternative to the AO relation is the explicit dependence of the coefficient of the anomalous diffusion on the system’s size, i.e. the absence of its thermodynamical limit. The prerequisite for its breakdown is the dependence of the local structure of possible steps of the RW on the system’s size. The discussion is illustrated by the examples of diffusion on a Koch curve (AO-conform) and on a Cantor dust (violating AO relation).

  19. Cyclicity in Silurian island-arc carbonates, Alexander terrane, Alaska

    SciTech Connect

    Kittredge, L.E.; Soja, C.M. . Dept. of Geology)

    1993-03-01

    Silurian carbonates from Alaska (Alexander terrane) record the evolution of a submarine platform during waning volcanism in an island arc. A detailed stratigraphic analysis of a 47 meter-thick sequence revealed the existence of cyclically repeated limestones: coral-stromatoporoid wackestones alternate with oncoid packstones and bioturbated, silty lime mudstones. The coral-stromatoporoid deposits are characterized by a low-diversity assemblage of dendroid corals, massive stromatoporoids, Atrypoidea brachiopods, and rare occurrences of biostromes associated with Solenopora, high-spired gastropods, and crinoids. Oncoids typically are 2-6 mm in diameter and form massive, meter-thick units. Coated grains are symmetrically developed, have a shell or algal nucleus, and are also a minor component of coral-stromatoporoid beds. These lithologic units form seven, shallowing-upwards cycles (parasequences) that range in thickness from 3-9 meters. Coral-stomatoporoid wackestones form the base of each cycle and grade upwards into oncoid packstones with silty, lime mudstones at the top. This succession of lithofacies within each cycle reflects an increase in energy levels from relatively deeper water environments to relatively shallower ones. The lack of abrasion in the corals and stromatoporoids suggests predominantly quiet-water conditions in shallow subtidal areas affected by periodic turbulence. Comparison with correlative sections in Alaska and lack of correspondence with global sea level curves suggest that the primary cause of cyclicity was tectonic perturbations with secondary eustatic effects. Cyclic deposition in peri/subtidal sites was terminated by rapid drowning of the carbonate platform during late Silurian orogenesis.

  20. The life and death of Alexander Bogdanov, physician.

    PubMed

    Huestis, D W

    1996-08-01

    It was early in April in 1928 when the word went out in Moscow that Alexander Bogdanov had died. He was a controversial figure, an old Bolshevik who had left that party long before the 1917 revolution and never returned. All the same, he had had Lenin's respect as a scientist (as long as he stayed out of politics). More recently, he also had the support of the new party strong man, Stalin. Bogdanov opposed the growing despotism of the "dictatorship of the proletariat", under which slogan Communist autocracy was being developed. But he was respected as a tireless propagandist for the socialist cause, an enthusiastic teacher of the proletariat, and a writer of arcane science and philosophy. Bogdanov was held in such respect that Communist bigwigs spoke glowingly at the funeral, praising his intellect, courage, and dedication to science and humanity. They did not fail to point out that he had split with his one-time friend, Lenin, and had succumbed to ideological "errors". Indeed, he had powerful enemies in the early Soviet state. Bogdanov was a physician, economist, philosopher, natural scientist, writer of utopian science fiction, poet, teacher, politician (unsuccesful), lifelong revolutionary, forerunner of what we now call cybernetics and organizational science, and founder of the world's first institution devoted entirely to the field of blood transfusion. You could call him a Renaissance man. Although he clearly fitted the category of the late-nineteenth-century Russian intellectual revolutionary, Bogdanov differed from most of them in being no dilettante. More than just a theorist, he was an active scientist and physician. As a teacher, he firmly believed that education and indoctrination could alter people's ways of thinking and behaving, and that humanity could be perfected under socialism. Like many revolutionaries, Bogdanov tried to keep ahead of the Tsar's police by using a variety of pseudonyms, among them Riadavoy, Werner, Maximov, and Bogdanov. After

  1. Educating with the hands: working on the body/self in Alexander Technique.

    PubMed

    Tarr, Jennifer

    2011-02-01

    Traditionally, forms of body work such as Alexander Technique have been excluded from mainstream biomedicine and healthcare, despite attempts by practitioners to have the work accepted within the medical community. Using data from a UK-based study of Alexander Technique which combined participant observation, interviews with 17 teachers and pupils, and analysis of historical texts, this article examines the relationship of the Alexander Technique to the field of healthcare, looking at its embodied practices, and contrasting these with the discourses in which it is framed. Applying Foucault's concept of 'techniques of the self', the article examines Alexander Technique's physical practices as a form of embodied knowledge, and goes on to look at its use of particular ideas about nature and evolution as guiding authorities, its emphasis on holism through its conception of the 'self', and how it has been positioned in relation to biomedical approaches. The article argues that while the embodied practice of Alexander Technique has much to offer to mainstream healthcare, the discourses and knowledge systems in which it is embedded make it unlikely to receive mainstream medical acceptance.

  2. Programmierung von Werkzeugmaschinen

    NASA Astrophysics Data System (ADS)

    Ahrberg, Rainer; Barfels, Lutz; Voss, Jürgen

    In den 1950-er Jahren wurde am Bostoner MIT (Massachusetts Institute of Technology) die Grundlage der modernen CNC-Technik gelegt. Für die spanende Herstellung von Rotorprofilen für Hubschrauber auf Basis vorab berechneter Konturverläufe wurden erstmalig Steuerungen auf Basis diskreter elektronischer Bauelemente entwickelt. Mit der Einführung integrierter elektronischer Schaltkreise (ICs) begann diese Technologie schrittweise Einzug in die Werkzeugmaschinenindustrie zu halten. Neben der Entwicklung der Hardware wurde die Programmierung und die Entwicklung von entsprechenden Programmiersprachen ein für die Akzeptanz dieser Technologie entscheidende Größe.

  3. Obituary: Alexander (Andy) Franz Lubenow, 1956-2005

    NASA Astrophysics Data System (ADS)

    Buie, Marc William

    2006-12-01

    Alexander (Andy) Franz Lubenow, Program Coordinator at the Space Telescope Science Institute, was diagnosed with cancer of the gallbladder, pancreas, and liver in May 2005 and died on 29 September 2005. He was forty-nine. Andy was born to Bodo and Helen Lubenow in St. Paul, Minnesota on 4 January 1956. In 1964 at the age of eight, he moved with his family to Buenos Aires, Argentina, and attended the American Community School there until returning with his family in 1973 to St. Paul. Argentina had a big impact on Andy's future as an astronomer. He later recalled how he had observed and was puzzled by the "upside-down" appearance of the Moon in the southern hemisphere. In Argentina, he built his first telescope using a mirror he had ground himself. He never parted ways with that instrument. Andy did not follow a standard educational track. He spent two years at St. Olaf College in Northfield, Minnesota, before transferring to the University of Minnesota, where he earned his bachelor's degree and began work towards a master's degree in astrophysics. Later he transferred to the University of Illinois at Urbana-Champaign, where he remained until Dr. Peter Stockman hired him to work on the Hubble Space Telescope project. While in school, he worked as a teacher's assistant, taught night school, and gave demonstrations of stargazing. He was an excellent teacher and had a flair for writing. He later wrote articles for a sailing magazine and a pilot's magazine. Andy was a very practical, meticulous, and steady worker, attributes that he combined with an understated and dry sense of humor. He was always able to find a way through a problem, no matter how sticky. If a job required him to roll up his sleeves and get it done through hard work, he would persevere. Nevertheless, he was always on the lookout for an easier way. He had no patience for being forced to deal with stupid things for stupid reasons. At work at the Space Telescope Science Institute (STScI), Andy was

  4. Samuel Alexander Kinnier Wilson. Wilson's disease, Queen Square and neurology.

    PubMed

    Broussolle, E; Trocello, J-M; Woimant, F; Lachaux, A; Quinn, N

    2013-12-01

    This historical article describes the life and work of the British physician Samuel Alexander Kinnier Wilson (1878-1937), who was one of the world's greatest neurologists of the first half of the 20th century. Early in his career, Wilson spent one year in Paris in 1903 where he learned from Pierre-Marie at Bicêtre Hospital. He subsequently retained uninterrupted links with French neurology. He also visited in Leipzig the German anatomist Paul Flechsig. In 1904, Wilson returned to London, where he worked for the rest of his life at the National Hospital for the Paralysed and Epileptic (later the National Hospital for Nervous Diseases, and today the National Hospital for Neurology and Neurosurgery) in Queen Square, and also at Kings' College Hospital. He wrote on 'the old motor system and the new', on disorders of motility and muscle tone, on the epilepsies, on aphasia, apraxia, tics, and pathologic laughing and crying, and most importantly on Wilson's disease. The other objective of our paper is to commemorate the centenary of Wilson's most important work published in 1912 in Brain, and also in Revue Neurologique, on an illness newly recognized and characterized by him entitled "Progressive lenticular degeneration, a familial nervous disease associated with liver cirrhosis". He analyzed 12 clinical cases, four of whom he followed himself, but also four cases previously published by others and a further two that he considered in retrospect had the same disease as he was describing. The pathological profile combined necrotic damage in the lenticular nuclei of the brain and hepatic cirrhosis. This major original work is summarized and discussed in the present paper. Wilson not only delineated what was later called hepato-lenticular degeneration and Wilson's disease, but also introduced for the first time the terms extrapyramidal syndrome and extrapyramidal system, stressing the role of the basal ganglia in motility. The present historical work emphasizes the special

  5. Is research on soil erosion hazard and mitigation in the Global South still needed? (Alexander von Humbold Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Poesen, Jean

    2016-04-01

    Soil erosion represents a geomorphological and geological hazard that may cause environmental damage (land degradation), property damage, loss of livelihoods and services as well as social and economic disruption. Erosion not only lowers the quality of our soils on site, resulting in a drastic reduction of their ecosystem functions that play a vital role in daily life, but causes also significant sediment-related problems off site. To curb soil erosion problems, a range of soil conservation techniques and strategies have been designed and are being applied. Worldwide, ca. 62 000 research papers on soil erosion and 116 000 on soil conservation have been published (Web of Science, Dec. 2015). The number of such papers dealing with the Global South represents less than 20 % of all papers, despite the fact that many regions in this part of the world face significant soil erosion problems, aggravated by a rapidly growing population and major environmental changes. Given the large number of research papers on this topic, one might therefore conclude that we now know almost everything about the various soil erosion processes and rates, their factors and consequences as well as their control so that little new knowledge can still be added to the vast amount of available information. We refute this conclusion by pointing to some major research gaps that still need to be addressed if we want to use our soils in a more sustainable way. More specifically the following topics need more research attention: 1) improved understanding of both natural and anthropogenic soil erosion processes and their interactions, 2) scaling up soil erosion processes and rates in space and time, and 3) innovative techniques and strategies to prevent or reduce erosion rates. This will be illustrated with case studies from the Global South. If future research focuses on these research gaps, we will 1) better understand processes and their interactions operating at a range of spatial and temporal scales, their rates as well as their on-site and off-site impacts, which is crucial for better targeting erosion control measures and which is academically spoken rewarding, and 2) we will also be in a better position to select the most appropriate and effective soil erosion control techniques and strategies which are badly needed for a sustainable use of our soils in the Anthropocene and for the improvement of environmental conditions worldwide.

  6. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    A camerman catches Dr. Wernher Von Braun, Director of the Marshall Space Flight Center, his son, Peter, and daughter, Martgrit, as they arrive at the employee picnic held to celebrate man's first landing on the moon 6 days earlier. In the foreground is David R. Newby, Director of Administration and Technical Services at the Marshall Space Flight Center.

  7. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

  8. Analytik von Lebensmittelallergenen

    NASA Astrophysics Data System (ADS)

    Demmel, Anja; Hahn, Alexandra

    Ansonsten harmlose Lebensmittel oder deren Bestandteile können bei von Lebensmittelallergien betroffenen Personen Überempfindlichkeitsreaktionen auslösen. Hierbei kann es sich um immunvermittelte Lebensmittelallergien oder um Intoleranzen gegenüber bestimmten Lebensmittelbestandteilen handeln. Ein Beispiel für Letzteres ist die Laktoseintoleranz, welche durch einen Enzymdefekt hervorgerufen wird [1]. Im Gegensatz hierzu handelt es sich bei Lebensmittelallergien um Sofortreaktionen, die durch IgE-Antikörper gegen Antigene aus den Lebensmitteln hervorgerufen werden und zu verschiedenen körperlichen Beschwerden führen können. Bei den Antigenen, welche von den von Allergikern produzierten IgE-Antikörpern erkannt werden, handelt es sich vor allem um Proteine [2]. Symptome IgE-vermittelter Reaktionen können zum Beispiel Hautausschlag, eine Schwellung der Schleimhäute oder das sogenannte orale Allergiesyndrom mit allergischen Reaktionen an der Mundschleimhaut und im Magen-Darm-Trakt sein [3]. Die hierbei auftretenden Beschwerden reichen von einem Brennen im Mund und einer Schwellung der Lippen und der Zunge bis zu Atemnot verursachenden Schwellungen im Kehlkopfbereich. In besonders schlimmen Fällen können allergische Reaktionen zu einem anaphylaktischen Schock und zum Tod durch Kreislaufversagen führen [4]. Während klassische Nahrungsallergene häufig komplexe Reaktionen zur Folge haben, ist bei Pollen-assoziierten Nahrungsmittelallergien das orale Allergiesyndrom vorherrschend.

  9. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Marshall Space Flight Center director Wernher Von Braun and his family were honored with a series of events prior to his relocation to Washington, D.C. where he was assigned duties at NASA headquarters as deputy associate administrator for planning. Here he is shown with General Richard Drury and Hazel Toftoy, widow of General H.N. Toftoy.

  10. Energetische Verwertung von Biomasse

    NASA Astrophysics Data System (ADS)

    Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    Etwa 0,1% der Solarenergie wandeln sich durch Photosynthese aus dem Kohlendioxid der Luft in Biomasse um. Die Biomassen sind als Festbrennstoff nutzbar oder zu gasförmigen Brennstoffen weiterverarbeitbar. Zwei Arten von Biomassen sind zu unterscheiden: Anfallende Biomasse

  11. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher von Braun, Director of the Marshall Space Flight Center, explains the purpose of a thermal curtain in the mockup of a Saturn I workshop to U.S. Representative Armistead Seldon of Alabama. The Congressman visited the Marshall Center on March 2, 1968 to tour the workshop and to visit Marshall Center facilities.

  12. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    U.S. Representative Armistead Seldon (D.-Al) inspects the food preparation area of the Saturn I workshop mockup during a visit to the Marshall Space Flight Center. Explaining the operation of the food preparation area to the congressman is Dr. Wernher Von Braun, Marshall Space Flight Center director.

  13. IN MEMORIAM: In Memoriam: Alexander A Golovin and Alexei M Oparin In Memoriam: Alexander A Golovin and Alexei M Oparin

    NASA Astrophysics Data System (ADS)

    2008-10-01

    In Memoriam of Alexander A Golovin (1962-2008) Alexander (Sasha) Golovin passed away on 10 September 2008. Sasha's scientific heritage includes seminal works in different fields of physics, from Marangoni convection to self-assembly of quantum dots, and from combustion fronts to anomalous diffusion in flows and on a crystal surface. A graduate of the Moscow Institute for Physics and Technology, he had very broad scientific interests and a unique ability to identify and solve new, intellectually challenging and technologically important problems. One of the basic fields of Sasha's research was the fluid dynamics in systems with interfaces. His favorite subject was the motion of droplets, bubbles and particles in the presence of heat and mass transfer. Sasha's early works contained the discovery of the spontaneous motion of droplets due to the Marangoni effect and the investigation of the interaction between solid particles, bubbles and droplets caused by the Marangoni effect, which is a crucial factor that determines the effect of heat/mass transfer on the rate of coalescence. In both cases, Sasha's work was the first in a long sequence of papers written by different authors. Later, Sasha returned to that field when studying such fascinating subjects as levitation of droplets above the surface of an evaporating liquid and encapsulation of particles and bubbles by an advancing solidification front. The subject of interfacial hydrodynamics overlaps with another basic field of Sasha's research, the theory of pattern formation. The contribution of Sasha's work to the modern understanding of the variety of pattern formation phenomena is significant. It includes the analysis of the interaction between long-wave and short-wave instability modes in Marangoni convection, investigation of the large-scale Marangoni convection that led to the prediction of different patterns including quasipatterns, and the description of various non-potential effects in Marangoni convection

  14. Dr. von Braun at 'Wernher von Braun Day' Celebration

    NASA Technical Reports Server (NTRS)

    1970-01-01

    In 1970 Marshall Space Flight Center (MSFC) Director Dr. Wernher von Braun (right) was reassigned to NASA Headquarters to serve as Deputy Associate Administrator for Plarning. Prior to his transfer, Dr. von Braun was honored for his career in Huntsville, Alabama, with the celebration of 'Wernher von Braun Day.' Among those participating were Alabama Governor Albert Brewer (left) and Alabama Senator John Sparkman (center). (Courtesy of Huntsville/Madison County Public library)

  15. Alexander Bain's CUE in the Post-Modern World: Unity Revisited.

    ERIC Educational Resources Information Center

    Dryden, Phyllis

    In 1866, Alexander Bain proposed that by evaluating unity, coherence, and emphasis (which he brought together under the acronym "CUE"), students could judge the effectiveness of their written paragraphs. One hundred twenty-five years later, the proposition is still central to composition instruction. A review of modern writing textbooks reveals…

  16. A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911

    ERIC Educational Resources Information Center

    Cotter, Donald

    2008-01-01

    The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His authoritative…

  17. 76 FR 54800 - Sandy Alexander, Clifton, NJ; Notice of Negative Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... Employment and Training Administration Sandy Alexander, Clifton, NJ; Notice of Negative Determination on... (subject firm). The Department's Notice was published in the Federal Register on February 2, 2011 (76 FR... resulted in a negative determination based on the findings that the petitioning worker group did not...

  18. Holocene morphogenesis of Alexander the Great's isthmus at Tyre in Lebanon

    NASA Astrophysics Data System (ADS)

    Marriner, Nick; Morhange, Christophe; Meulé, Samuel

    2007-05-01

    In 332 B.C., Alexander the Great constructed an ≈1,000-m-long causeway to seize the offshore island of Tyre. The logistics behind this engineering feat have long troubled archaeologists. Using the Holocene sedimentary record, we demonstrate that Alexander's engineers cleverly exploited a shallow proto-tombolo, or sublittoral sand spit, to breach the offshore city's defensive impregnability. We elucidate a three-phase geomorphological model for the spit's evolution. Settled since the Bronze Age, the area's geological record manifests a long history of natural and anthropogenic forcings. (i) Leeward of the island breakwater, the maximum flooding surface (e.g., drowning of the subaerial land surfaces by seawater) is dated ≈8000 B.P. Fine-grained sediments and brackish and marine-lagoonal faunas translate shallow, low-energy water bodies at this time. Shelter was afforded by Tyre's elongated sandstone reefs, which acted as a 6-km natural breakwater. (ii) By 6000 B.P., sea-level rise had reduced the dimensions of the island from 6 to 4 km. The leeward wave shadow generated by this island, allied with high sediment supply after 3000 B.P., culminated in a natural wave-dominated proto-tombolo within 1-2 m of mean sea level by the time of Alexander the Great (4th century B.C.). (iii) After 332 B.C., construction of Alexander's causeway entrained a complete anthropogenic metamorphosis of the Tyrian coastal system.

  19. Old Age, the Ancient Military, and Alexander's Army: Positive Examples for a Graying America.

    ERIC Educational Resources Information Center

    Kebric, Robert B.

    1988-01-01

    Presents examples from ancient Greece and Rome illustrating working aged and intergenerational dependence. Describes normal active participation of elderly as officers and common soldiers in ancient military as example of their capabilities. Notes that Alexander the Great's army, in particular, depended on contributions of older men. (Author/NB)

  20. "In the Footsteps of Alexander the Great" PBS Series. Teacher's Guide.

    ERIC Educational Resources Information Center

    Corporation for Public Broadcasting, Washington, DC.

    This teacher's guide correlates with the Public Broadcasting Service (PBS) television series "In the Footsteps of Alexander the Great" hosted by historian Michael Wood. The four episodes of the series are entitled: "Son of God"; "Lord of Asia"; "Across the Hindu Kush"; and "To the Ends of the Earth." The guide consists of four core units related…

  1. Holocene morphogenesis of Alexander the Great's isthmus at Tyre in Lebanon.

    PubMed

    Marriner, Nick; Morhange, Christophe; Meulé, Samuel

    2007-05-29

    In 332 B.C., Alexander the Great constructed an approximately 1,000-m-long causeway to seize the offshore island of Tyre. The logistics behind this engineering feat have long troubled archaeologists. Using the Holocene sedimentary record, we demonstrate that Alexander's engineers cleverly exploited a shallow proto-tombolo, or sublittoral sand spit, to breach the offshore city's defensive impregnability. We elucidate a three-phase geomorphological model for the spit's evolution. Settled since the Bronze Age, the area's geological record manifests a long history of natural and anthropogenic forcings. (i) Leeward of the island breakwater, the maximum flooding surface (e.g., drowning of the subaerial land surfaces by seawater) is dated approximately 8000 B.P. Fine-grained sediments and brackish and marine-lagoonal faunas translate shallow, low-energy water bodies at this time. Shelter was afforded by Tyre's elongated sandstone reefs, which acted as a 6-km natural breakwater. (ii) By 6000 B.P., sea-level rise had reduced the dimensions of the island from 6 to 4 km. The leeward wave shadow generated by this island, allied with high sediment supply after 3000 B.P., culminated in a natural wave-dominated proto-tombolo within 1-2 m of mean sea level by the time of Alexander the Great (4th century B.C.). (iii) After 332 B.C., construction of Alexander's causeway entrained a complete anthropogenic metamorphosis of the Tyrian coastal system.

  2. The Alexander N. Charters Library of Resources for Educators of Adults at Syracuse University Library.

    ERIC Educational Resources Information Center

    Keenan, Terrance

    This document describes the contents of the Alexander N. Charters Library of Resources for Educators of Adults at Syracuse University Library. The document begins with a brief history of the development of the library's collections, which occupy 900 feet of shelf space and contain more than 50 groups of personal papers and records of organizations…

  3. Alexander v. Yale: Collected Documents from the Yale Undergraduate Women's Caucus and Grievance Committee.

    ERIC Educational Resources Information Center

    Yale Univ., New Haven, CT.

    Papers concerning the lawsuit charging that Yale University condones sexual harassment of women students, Alexander v. Yale, have been compiled by the Yale Undergraduate Women's Caucus. The specifics of the case are described by Caucus publications and press releases. The suit, filed in July 1977 by four female undergraduates and one male…

  4. Alexander Cameron Rutherford: A Gentleman and a Scholar. Documents in the Classroom.

    ERIC Educational Resources Information Center

    Hodysh, Henry W.

    2000-01-01

    Provides information about Alexander Cameron Rutherford, a provincial politician. Includes a letter written by Rutherford in 1912 that provides insights into his responsibilities to the general public, information about Rutherford himself, the economic conditions of Alberta, Canada in 1912, and information about the individual to whom it was…

  5. Holocene morphogenesis of Alexander the Great's isthmus at Tyre in Lebanon

    PubMed Central

    Marriner, Nick; Morhange, Christophe; Meulé, Samuel

    2007-01-01

    In 332 B.C., Alexander the Great constructed an ≈1,000-m-long causeway to seize the offshore island of Tyre. The logistics behind this engineering feat have long troubled archaeologists. Using the Holocene sedimentary record, we demonstrate that Alexander's engineers cleverly exploited a shallow proto-tombolo, or sublittoral sand spit, to breach the offshore city's defensive impregnability. We elucidate a three-phase geomorphological model for the spit's evolution. Settled since the Bronze Age, the area's geological record manifests a long history of natural and anthropogenic forcings. (i) Leeward of the island breakwater, the maximum flooding surface (e.g., drowning of the subaerial land surfaces by seawater) is dated ≈8000 B.P. Fine-grained sediments and brackish and marine-lagoonal faunas translate shallow, low-energy water bodies at this time. Shelter was afforded by Tyre's elongated sandstone reefs, which acted as a 6-km natural breakwater. (ii) By 6000 B.P., sea-level rise had reduced the dimensions of the island from 6 to 4 km. The leeward wave shadow generated by this island, allied with high sediment supply after 3000 B.P., culminated in a natural wave-dominated proto-tombolo within 1–2 m of mean sea level by the time of Alexander the Great (4th century B.C.). (iii) After 332 B.C., construction of Alexander's causeway entrained a complete anthropogenic metamorphosis of the Tyrian coastal system. PMID:17517668

  6. Identification of metapopulation dynamics among Northern Goshawks of the Alexander Archipelago, Alaska, and Coastal British Columbia

    USGS Publications Warehouse

    Sonsthagen, Sarah A.; McClaren, Erica L.; Doyle, Frank I.; Titus, K.; Sage, George K.; Wilson, Robert E.; Gust, J.R.; Talbot, Sandra L.

    2012-01-01

    Northern Goshawks occupying the Alexander Archipelago, Alaska, and coastal British Columbia nest primarily in old-growth and mature forest, which results in spatial heterogeneity in the distribution of individuals across the landscape. We used microsatellite and mitochondrial data to infer genetic structure, gene flow, and fluctuations in population demography through evolutionary time. Patterns in the genetic signatures were used to assess predictions associated with the three population models: panmixia, metapopulation, and isolated populations. Population genetic structure was observed along with asymmetry in gene flow estimates that changed directionality at different temporal scales, consistent with metapopulation model predictions. Therefore, Northern Goshawk assemblages located in the Alexander Archipelago and coastal British Columbia interact through a metapopulation framework, though they may not fit the classic model of a metapopulation. Long-term population sources (coastal mainland British Columbia) and sinks (Revillagigedo and Vancouver islands) were identified. However, there was no trend through evolutionary time in the directionality of dispersal among the remaining assemblages, suggestive of a rescue-effect dynamic. Admiralty, Douglas, and Chichagof island complex appears to be an evolutionarily recent source population in the Alexander Archipelago. In addition, Kupreanof island complex and Kispiox Forest District populations have high dispersal rates to populations in close geographic proximity and potentially serve as local source populations. Metapopulation dynamics occurring in the Alexander Archipelago and coastal British Columbia by Northern Goshawks highlight the importance of both occupied and unoccupied habitats to long-term population persistence of goshawks in this region.

  7. Friendly Letters on the Correspondence of Helen Keller, Anne Sullivan, and Alexander Graham Bell.

    ERIC Educational Resources Information Center

    Blatt, Burton

    1985-01-01

    Excerpts from the letters between Alexander Graham Bell and Anne Sullivan and Helen Keller are given to illustrate the educational and personal growth of Helen Keller as well as the educational philosophy of Bell regarding the education of the deaf blind. (DB)

  8. 78 FR 30791 - Airworthiness Directives; Alexander Schleicher GmbH & Co. Segelflugzeugbau Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... new airworthiness directive (AD) for all Alexander Schleicher GmbH & Co. Segelflugzeugbau Models AS-K13, Ka2B, Ka 6, Ka 6 B, Ka 6 BR, Ka 6 C, Ka 6 CR, K7, K8, and K 8 B sailplanes that would supersede... aviation product. The MCAI describes the unsafe condition as misalignment of the automatic elevator...

  9. Connect the Book. Always Inventing: A Photobiography of Alexander Graham Bell

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2004-01-01

    Cell phones, video phones, voice messaging?one wonders what Alexander Graham Bell would have thought about the many venues today for electronic communication with one another. Bell's March 10, 1876 invention is now 128 years old, but there is no doubt that Bell's "talking machine" changed the world. This article presents a brief review of the…

  10. Russia's Literary Genius Alexander Pushkin: The Great-Grandson of an African Slave.

    ERIC Educational Resources Information Center

    Lounsbery, Anne

    2000-01-01

    Alexander Pushkin, Russia's most celebrated literary figure, descended from an African slave. On both parents' sides, he was related to Avram Petrovich Gannibal, who was born to an African prince and abducted to become a slave to a Russian diplomat. Pushkin chose to pride himself on both his aristocratic life and his African ancestry. (SM)

  11. Optimierung von Kommunikationsnetzen

    NASA Astrophysics Data System (ADS)

    Eberspächer, Jörg; Kiese, Moritz; Wessäly, Roland

    Die weltweiten Telekommunikationsnetze (Telefon-, Mobilfunknetze, Internet) bilden heute das Nervensystem von Wirtschaft und Gesellschaft. Durch den anhaltenden technologischen Fortschritt in der Elektronik, der Computer- und Kommunikationstechnik steigt nicht nur die Zahl der Teilnehmer in den Netzen ständig, sondern es entstehen auch laufend neue Anwendungen, wie Radio und Fernsehen im Internet, elektronischer Handel und interaktive Spiele im Internet. Auf den Kupfer- und Glasfaserkabeln sowie den Funkstrecken werden gigantische Informationsmengen transportiert. Das Verkehrs-wachstum ist nach wie vor exponentiell.

  12. Obituary: Alexander (Andy) Franz Lubenow, 1956-2005

    NASA Astrophysics Data System (ADS)

    Buie, Marc William

    2006-12-01

    Alexander (Andy) Franz Lubenow, Program Coordinator at the Space Telescope Science Institute, was diagnosed with cancer of the gallbladder, pancreas, and liver in May 2005 and died on 29 September 2005. He was forty-nine. Andy was born to Bodo and Helen Lubenow in St. Paul, Minnesota on 4 January 1956. In 1964 at the age of eight, he moved with his family to Buenos Aires, Argentina, and attended the American Community School there until returning with his family in 1973 to St. Paul. Argentina had a big impact on Andy's future as an astronomer. He later recalled how he had observed and was puzzled by the "upside-down" appearance of the Moon in the southern hemisphere. In Argentina, he built his first telescope using a mirror he had ground himself. He never parted ways with that instrument. Andy did not follow a standard educational track. He spent two years at St. Olaf College in Northfield, Minnesota, before transferring to the University of Minnesota, where he earned his bachelor's degree and began work towards a master's degree in astrophysics. Later he transferred to the University of Illinois at Urbana-Champaign, where he remained until Dr. Peter Stockman hired him to work on the Hubble Space Telescope project. While in school, he worked as a teacher's assistant, taught night school, and gave demonstrations of stargazing. He was an excellent teacher and had a flair for writing. He later wrote articles for a sailing magazine and a pilot's magazine. Andy was a very practical, meticulous, and steady worker, attributes that he combined with an understated and dry sense of humor. He was always able to find a way through a problem, no matter how sticky. If a job required him to roll up his sleeves and get it done through hard work, he would persevere. Nevertheless, he was always on the lookout for an easier way. He had no patience for being forced to deal with stupid things for stupid reasons. At work at the Space Telescope Science Institute (STScI), Andy was

  13. Theodore von Karman

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. Theodore von Karman, co-founder of the Jet Propulsion Laboratory (JPL) Pasadena, California was an aeronautical theoretician. His contributions in the fields of aerodynamics and aeronautical engineering are well documented and well known to every aerospace engineer. He was the first winner of the prestigious U.S. Medal of Science presented to him by President John F. Kennedy. As well as being co-founder of JPL, he also was principal founder of a major rocket propulsion firm (Aerojet-General Corp.), the top science advisor to the U.S. Air Force during its transition to jet propulsion aircraft and the top science advisor to NATO. He was, during much of this time, the fountainhead of aerodynamic thought as head of the Guggenheim Aeronautical Laboratory at the California Institute of Technology (GALCIT) in Pasadena, California. In the May 1956 issue of the Journal of Aeronautical Sciences, it was said of him that 'No other man has had so great an impact on the development of aeronautical science in this country. Hundreds of young men became his students and scientific collaborators and were inspired to greater effort.' Dr. William H. Pickering, then director of JPL said in 1960 'We wouldn't have an aeronautical science as we know it today, if it weren't for Dr. Thoedore von Karman.' Under his guidance, Caltech's 10 foot wind tunnel was designed, built and operated. Industry firms such as Douglas, Northrop, Hughes, Lockheed, North American, Vultee and Consolidated all tested new aeronautical designs and concepts in GALCIT's tunnel. Even Boeing's own high-speed wind tunnel was heavily influenced by suggestions from von Karman. The National Advisory Committee for Aeronautics (NACA) became so concerned about GALCIT's growing influence over West coast aviation, it erected the Ames Laboratory in Sunnyvale, California in part to deter an ever widening aeronautical gap that had formed between NACA and GALCIT. From 1936 to 1940, Caltech stood alone as the only university

  14. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

  15. Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model

    PubMed Central

    Wang, Liqun; Colodner, Kenneth J.; Feany, Mel B.

    2011-01-01

    Although alterations in glial structure and function commonly accompany death of neurons in neurodegenerative diseases, the role glia play in modulating neuronal loss is poorly understood. We have created a model of Alexander disease in Drosophila by expressing disease-linked mutant versions of glial fibrillary acidic protein (GFAP) in fly glia. We find aggregation of mutant human GFAP into inclusions bearing the hallmarks of authentic Rosenthal fibers. We also observe significant toxicity of mutant human GFAP to glia, which is mediated by protein aggregation and oxidative stress. Both protein aggregation and oxidative stress contribute to activation of a robust autophagic response in glia. Toxicity of mutant GFAP to glial cells induces a non-cell autonomous stress response and subsequent apoptosis in neurons, which is dependent on glial glutamate transport. Our findings thus establish a simple genetic model of Alexander disease and further identify cellular pathways critical for glial-induced neurodegeneration. PMID:21414908

  16. Clinical Experience in Late Antiquity: Alexander of Tralles and the Therapy of Epilepsy

    PubMed Central

    Bouras-vallianatos, Petros

    2014-01-01

    Alexander of Tralles, writing in the late sixth century, combined his wide-ranging practical knowledge with earlier medical theories. This article shows how clinical experience is used in Alexander’s works by concentrating on his therapeutic advice on epilepsy and, in particular, on pharmacology and the group of so-called natural remedies. I argue that clinical testing is used not only for the introduction of new medicines but also as an instrument for checking the therapeutic effect of popular healing practices. On another level, this article discusses Alexander’s role as the author of a medical compendium; it suggests that by marking the cases of clinical testing with a set of recurrent expressions, Alexander leads his audience to reflect on his medical authority and personal contribution. PMID:25045178

  17. Pennsylvanian pluton stitching of Wrangellia and the Alexander terrane, Wrangell Mountains, Alaska

    SciTech Connect

    Gardner, M.C.; Bergman, S.C.; Cushing, G.W. ); Plafker, G. ); Campbell, R.B.; Dodds, C.J. ); McClelland, W.C. ); Mueller, P.A. ); MacKevett, E.M. Jr.

    1988-11-01

    A quartz monzonite-syenite-alkali granite plutonic complex in eastern Alaska crosscuts the contact of the Alexander terrane and Wrangellia and intrudes the basement rocks of both terranes. Zircon U-Pb data indicate an intrusion age of 309 {plus minus} 5 Ma (Middle Pennsylvanian) for the pluton, and {sup 40}K-{sup 40}Ar age for hornblende separates indicate cooling to about 450 C during Middle Pennsylvanian-Early Permian time. The new field relations and age data demonstrate the Wrangellia and the Alexander terrane were contiguous during the Middle Pennsylvanian. This conclusion provides an important new constraint on paleogeographic reconstructions of the northwest Cordillera, and necessitates reassessment of stratigraphic and paleomagnetic data that were cited as evidence that the terranes evolved separately until the late Mesozoic.

  18. Paleozoic paleomagnetism and northward drift of the Alexander Terrane, southeastern Alaska

    NASA Astrophysics Data System (ADS)

    van Der Voo, Rob; Jones, Meridee; Gromme, C. Sherman; Eberlein, G. Donald; Churkin, Michael, Jr.

    1980-10-01

    Paleozoic limestone, graywacke, sandstone, milestone, red beds and volcanic rocks of the Alexander terrane, southeastern Alaska, have yielded six paleomagnetic pole positions after thermal and alternating-field demagnetization. These poles are from sample groups of late Middle Ordovician, Late Ordovician, Devonian, Late Devonian, and early and late Carboniferous age. To test various tectonic models for the structural development of this part of western North America, the paleomagnetic results are compared to those for the North American craton. It is found that the observed inclination and declination values deviate significantly from the values predicted for the present-day position of the Alexander terrane (55.5N, 133.5W). Better matching can be obtained for a paleoposition of the terrane at about 40N, 120W, in the present position of western Nevada and northeastern California. In addition, an in situ 25° clockwise rotation of the terrane is required to restore it to its original position.

  19. Scaphopoda from the Alexander Terrane, Southeast Alaska-The first occurrence of Scaphopoda in the Silurian

    USGS Publications Warehouse

    Rohr, D.M.; Blodgett, R.B.; Baichtal, J.

    2006-01-01

    The scaphopods Dentalium hecetaensis n. sp. and Rhytiodentalium cf. kentuckyensis Pojeta et Runnegar, 1979, are described from Ludlow-age strata of the Heceta Limestone on Prince of Wales Island, Southeast Alaska. This is the first occurrence of Silurian scaphopods known to date. They are part of a diverse macrobenthic fauna of the Alexander terrane, an accreted southern Alaskan terrane of Siberian or Uralian affinities. ?? 2006 Nanjing Institute of Geology and Palaeontology, CAS.

  20. A stone at the Siege of Cyropolis and the death of Alexander the Great.

    PubMed

    Williams, Andrew N; Arnott, Robert

    2004-06-01

    Alexander the Great was struck by a stone at the Siege of Cyropolis in 329 BC and was rendered temporarily blind and inaudible as a result. Although other authors have written extensively about the likely pathological effects of this injury, none have suggested carotid artery dissection as a possible cause. We present evidence that this should be considered as a differential diagnosis and how it might explain an unusual symptom seen at his deathbed in Babylon six years later.

  1. Professor Robert McNeill Alexander CBE FRS (1934-2016).

    PubMed

    Ker, Robert F

    2016-07-01

    Robert McNeill Alexander, known to friends and colleagues as 'Neill', was a zoologist with an engineer's eye for how animals work. He used mathematical models to show how evolution has produced optimal designs. His skill was to choose appropriate models: realistic enough to contain the essence of a problem and yet simple enough to be tractable. He wrote fluently and easily: 23 books, 280 papers and a CD-ROM entitled How Animals Move. PMID:27385751

  2. PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity.

    PubMed Central

    Daemer, R J; Feinstone, S M; Alexander, J J; Tully, J G; London, W T; Wong, D C; Purcell, R H

    1980-01-01

    The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did not reveal evidence of synthesis of additional hepatitis B virus markers or of production of infectious virus. Images Fig. 1 Fig. 2 Fig. 3 PMID:6160110

  3. Alexander H. Leighton's and Jane Murphy's scientific contributions in psychiatric epidemiology: a personal appreciation.

    PubMed

    Tremblay, Marc-Adélard

    2006-03-01

    This article introduces the special issue of Transcultural Psychiatry in honour of Alexander Leighton. A sketch of his research career is followed by a discussion of the work of his wife, Dr. Jane Murphy, first on St. Lawrence Island, near the Bering Strait, and later as a key figure in the Stirling County project. A brief conclusion highlights the main aspects of their joint legacy to cultural psychiatry and psychiatric epidemiology. PMID:16671389

  4. Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.

    PubMed

    LaPash Daniels, Christine M; Paffenroth, Elizabeth; Austin, Elizabeth V; Glebov, Konstantin; Lewis, Diana; Walter, Jochen; Messing, Albee

    2015-01-01

    Alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (GFAP). The disease is characterized by elevated levels of GFAP and the formation of protein aggregates, known as Rosenthal fibers, within astrocytes. Lithium has previously been shown to decrease protein aggregates by increasing the autophagy pathway for protein degradation. In addition, lithium has also been reported to decrease activation of the transcription factor STAT3, which is a regulator of GFAP transcription and astrogliogenesis. Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. Mice with the Gfap-R236H point mutation were fed lithium food pellets for 4 to 8 weeks. Four weeks of treatment with LiCl at 0.5% in food pellets decreased GFAP protein and transcripts in several brain regions, although with mild side effects and some mortality. Extending the duration of treatment to 8 weeks resulted in higher mortality, and again with a decrease in GFAP in the surviving animals. Indicators of autophagy, such as LC3, were not increased, suggesting that lithium may decrease levels of GFAP through other pathways. Lithium reduced the levels of phosphorylated STAT3, suggesting this as one pathway mediating the effects on GFAP. In conclusion, lithium has the potential to decrease GFAP levels in Alexander disease, but with a narrow therapeutic window separating efficacy and toxicity.

  5. Teachers' professional development needs and current practices at the Alexander Science Center School

    NASA Astrophysics Data System (ADS)

    Gargus, Gerald Vincent

    This investigation represents an in-depth understanding of teacher professional development at the Alexander Science Center School, a dependent charter museum school established through a partnership between the California Science Center and Los Angeles Unified School District. Three methods of data collection were used. A survey was distributed and collected from the school's teachers, resulting in a prioritized list of teacher professional development needs, as well as a summary of teachers' opinions about the school's existing professional development program. In addition, six key stakeholders in the school's professional development program were interviewed for the study. Finally, documents related to the school's professional development program were analyzed. Data collected from the interviews and documents were used to develop an understand various components of the Alexander Science Center School's professional development program. Teachers identified seven areas that had a high-priority for future professional development including developing skills far working with below-grade-level students, improving the analytical skills of student in mathematics, working with English Language Learners, improving students' overall reading ability levels, developing teachers' content-area knowledge for science, integrating science across the curriculum, and incorporating hands-on activity-based learning strategies to teach science. Professional development needs identified by Alexander Science Center School teachers were categorized based on their focus on content knowledge, pedagogical content knowledge, or curricular knowledge. Analysis of data collected through interviews and documents revealed that the Alexander Science Center School's professional development program consisted of six venues for providing professional development for teachers including weekly "banked time" sessions taking place within the standard school day, grade-level meetings, teacher support

  6. Wolfgang von Ohnesorge

    NASA Astrophysics Data System (ADS)

    McKinley, Gareth H.; Renardy, Michael

    2011-12-01

    This manuscript got started when one of us (G.H.M.) presented a lecture at the Institute of Mathematics and its Applications at the University of Minnesota. The presentation included a photograph of Rayleigh and made frequent mention of the Ohnesorge number. When the other of us (M.R.) enquired about a picture of Ohnesorge, we found out that none were readily available on the web. Indeed, little about Ohnesorge is available from easily accessible public sources. A good part of the reason is certainly that, unlike other "numbermen" of fluid mechanics, Ohnesorge did not pursue an academic career. The purpose of this article is to fill the gap and shed some light on the life of Wolfgang von Ohnesorge. We shall discuss the highlights of his biography, his scientific contributions, their physical significance, and their impact today.

  7. Von Hippel-Lindau Disease.

    PubMed

    Findeis-Hosey, Jennifer J; McMahon, Kelly Q; Findeis, Sarah K

    2016-06-01

    Von Hippel-Lindau disease is an autosomal dominant syndrome which occurs secondary to germline mutations in the VHL tumor suppressor gene, located on chromosome 3. Clinically von Hippel-Lindau disease is characterized by an increased risk of developing simple visceral cysts, most commonly in the pancreas and kidneys, in addition to an increased risk of developing neoplasms, often with clear cell features, in a multitude of organ systems. The most common neoplasms are cerebellar and retinal hemangioblastomas, adrenal pheochromocytomas, clear cell renal cell carcinomas, pancreatic neuroendocrine tumors, pancreatic serous cystadenomas, and endolymphatic sac tumors. These lesions most commonly present during adulthood; however, screening and surveillance for the development of these lesions should begin in the pediatric years for patients with von Hippel-Lindau disease. In this review article, the genetics and most common neoplasms of von Hippel-Lindau disease are reviewed, with an eye towards implications for the pediatric patient. PMID:27617152

  8. Pregnancy and von Gierke's disease.

    PubMed

    Farber, M; Knuppel, R A; Binkiewicz, A; Kennison, R D

    1976-02-01

    A detailed description of the course of pregnancy in a patient with von Gierke's disease is presented. Careful dietary control together with proper management of the hematologic complications of the disease led to a successful outcome. PMID:1061911

  9. von Braun and German Publisher

    NASA Technical Reports Server (NTRS)

    1969-01-01

    In this photograph, Guenter Ogger of Capitol Magazine, West Germany, greets Marshall Space Flight Center Director, Dr. Wernher von Braun. Mr. Ogger interviewed the famous rocket scientist for his magazine.

  10. Von Karman and JATO Team

    NASA Technical Reports Server (NTRS)

    1940-01-01

    Dr. Theodore von Karman (black coat) sketches out a plan on the wing of an airplane as his JATO engineering team looks on. From left to right: Dr. Clark B. Millikan, Dr.Martin Summerfield, Dr. Theodore von Karman, Dr. Frank J. Malina and pilot, Capt. Homer Boushey. Captain Boushey would become the first American to pilot an airplane that used JATO (Jet Assisted Take-Off) solid propellent rockets.

  11. Richard von Volkmann

    PubMed Central

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R.

    2008-01-01

    Richard von Volkmann (1830–1889), one of the most important surgeons of the 19th century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867–1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the “antiseptic technique” to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann’s contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children’s fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics. PMID:18196438

  12. Origin of Silurian reefs in the Alexander Terrane of southeastern Alaska

    SciTech Connect

    Soja, C.M. )

    1991-04-01

    Lower to Upper Silurian (upper Llandovery-Ludlow) limestones belonging to the Heceta Formation record several episodes of reef growth in the Alexander terrane of southeastern Alaska. As the oldest carbonates of wide-spread distribution in the region, the Heceta limestones represent the earliest development of a shallow-marine platform within the Alexander arc and the oldest foundation for reef evolution. These deposits provide important insights into the dynamic processes, styles, and bathymetry associated with reef growth in tectonically active oceanic islands. Massive stromatoporoids, corals, and red algae are preserved in fragmental rudstones and represent a fringing reef that formed at the seaward edge of the incipient marine shelf. Accessory constituents in this reef include crinoids and the cyanobacterium Girvanella. Small biostromes were constructed by ramose corals and stromatoporoids on oncolitic substrates in backreef or lagoonal environments. These buildups were associated with low-diversity assemblages of brachiopods and with gastropods, amphiporids, calcareous algae and cyanobacteria. Microbial boundstones reflect the widespread encrustation of cyanobacteria and calcified microproblematica on shelly debris as stromatolitic mats that resulted in the development of a stromatactoid-bearing mud mound and a barrier reef complex. Epiphytaceans, other microbes, and aphrosalpingid sponges were the primary frame-builders of the barrier reefs. These buildups attained significant relief at the shelf margin and shed detritus as slumped blocks and debris flows into deep-water sites along the slope. The similarity of these stromatolitic-aphrosalpingid reefs to those from Siluro-Devonian strata of autochthonous southwestern Alaska suggests paleobiogeographic ties of the Alexander terrane to cratonal North America during the Silurian.

  13. Alexander Fleming, citrated blood and penicillin: paths not pursued and applications delayed.

    PubMed

    Mortimer, P P

    2009-12-01

    Ninety years ago Alexander Fleming (later to discover penicillin) jointly wrote a description of the use of indirect transfusions of citrated blood at a World War 1 (WW1) base hospital. It was the longest series yet to be published, incorporating what was then a novel procedure for treating war casualties. Returning to civilian life Fleming, a qualified surgeon and bacteriologist, chose a different career path, and not until the wars of the late 1930s were the advances in transfusion in WW1 fully incorporated into the management of trauma and haemorrhage. Like penicillin, the benefits of indirect transfusion were only slowly realised.

  14. Alexander Dalgarno

    NASA Astrophysics Data System (ADS)

    Fox, Jane L.

    Alex Dalgarno saved my career. I entered the Graduate School at Harvard in the Chemistry Department in September of 1973 from the University of Michigan, where I had (unfortunately) majored in Chemistry. Chemistry is considered a "laboratory science" but I had no talent in the laboratory. I had merely fallen in love with the ideal gas law in high school, and I had stubbornly allowed this to determine my course of studies, most of which had nothing to do with the ideal gas law, and much of which was focused on laboratory studies...

  15. Alexander Disease

    MedlinePlus

    ... there are no ethnic, racial, geographic, or cultural/economic differences in its distribution. Is there any treatment? ... Fax: 815-748-0844 Prepared by: Office of Communications and Public Liaison National Institute of Neurological Disorders ...

  16. Improvement in Automatic Postural Coordination Following Alexander Technique Lessons in a Person With Low Back Pain

    PubMed Central

    Cacciatore, Timothy W; Horak, Fay B; Henry, Sharon M

    2006-01-01

    Background and Purpose The relationship between abnormal postural coordination and back pain is unclear. The Alexander Technique (AT) aims to improve postural coordination by using conscious processes to alter automatic postural coordination and ongoing muscular activity, and it has been reported to reduce low back pain. This case report describes the use of the AT with a client with low back pain and the observed changes in automatic postural responses and back pain. Case Description The client was a 49-year-old woman with a 25-year history of left-sided, idiopathic, lumbrosacral back pain. Automatic postural coordination was measured using a force plate during horizontal platform translations and one-legged standing. Outcomes The client was tested monthly for 4 months before AT lessons and for 3 months after lessons. Before lessons, she consistently had laterally asymmetric automatic postural responses to translations. After AT lessons, the magnitude and asymmetry of her responses and balance improved and her low back pain decreased. Discussion Further research is warranted to study whether AT lessons improve low back pain–associated abnormalities in automatic postural coordination and whether improving automatic postural coordination helps to reduce low back pain. [Cacciatore TW, Horak FB, Henry SM. Improvement in automatic postural coordination following Alexander Technique lessons in a person with low back pain. PMID:15921477

  17. Possible refugia in the Alexander Archipelago of southeastern Alaska during the late Wisconsin glaciation

    USGS Publications Warehouse

    Carrara, P.E.; Ager, T.A.; Baichtal, J.F.

    2007-01-01

    The interpretation of the extent of late Wisconsin glaciation in southeastern Alaska has varied between geologists and biologists. Maps and reports of the region prepared by geologists commonly indicated that late Wisconsin ice extended as a large uniform front west to the edge of the continental shelf. However, the distribution of plants and animals in the region has led many biologists to suggest that there may have been ice-free areas that served as refugia during the late Wisconsin. Based on analyses of aerial photographs, topographic maps, and bathymetric charts, in conjunction with a review of previous literature and reconnaissance fieldwork throughout the region, this study presents data supporting a limited ice extent in the Alexander Archipelago during the late Wisconsin and identifies possible ice-free areas that may have served as refugia. These areas include (1) the Fairweather Ground, (2) the Herbert Graves Island area, (3) the western coast of southern Baranof Island and adjacent continental shelf, (4) Coronation Island and the adjacent continental shelf, (5) the Warren Island area, (6) the continental shelf from west of Heceta Island to Forrester Island in the south, (7) parts of the west coast of southern Dall Island, and (8) lowland areas in southern Prince of Wales Island. The identification of these possible refugia has bearing on the recolonization of the Alexander Archipelago, as they could have served as centers of biotic dispersal upon regional deglaciation and as stepping stones for early humans with a maritime tradition entering the western hemisphere from Asia. ?? 2007 NRC Canada.

  18. Trace element analysis of Alexander the Great's silver tetradrachms minted in Macedonia

    NASA Astrophysics Data System (ADS)

    Kallithrakas-Kontos, N.; Katsanos, A. A.; Touratsoglou, J.

    2000-11-01

    The coinage of Alexander the Great presents a special interest because of its international character in the frame of the ancient times. At least 31 mints (from Aigai to Babylon and from Pella to Alexandreia) operated in the vast state, which was created by Alexander in just over 10 years (334-323 BC). Impressive quantities of tetradrachms were consequently minted for the economic affairs of an expanding state. The mints continued to be active and after the premature death of the Macedonian king, producing among others and tetradrachms in his name. The elemental chemical composition of silver tetradrachms minted in Amphipolis as well as in other Macedonian Greek cities was analysed by energy dispersive X-ray fluorescence (EDXRF), and 12 elements were determined. The problem of the patina (silver corrosion layer) effects on the results was examined by analysis before and after the corrosion product removal. From the results of the chemical composition, a similar numismatic policy is deduced for all the analysed coin as well as metal provenance indications for some of the coins.

  19. Alexander of Macedon, the greatest warrior of all times: did he have seizures?

    PubMed

    Hughes, John R

    2004-10-01

    Alexander the Great (356-323 BC) was likely "the most incomparable general the world has ever seen." His name is often listed among the famous individuals in history who have had seizures. Examination of his illnesses reveals that in 333 BC he entered Tarsus, hot and exhausted, and plunged himself into the River Cydnus, ice-cold from melting mountain snows. His cramps were so severe that he was rescued half-conscious and ashen white, and quickly developed acute pneumonia. Only one doctor dared give him a medication, known for producing powerful and immediate effects. Immediately after drinking this medicine "he lost his speech and falling into a swoon, he had scarcely any sense or pulse left" (Plutarch, ad 75). His reactions were the direct effect of the medication, and this and only this phrase represents the "evidence" for epilepsy. None of his other illnesses involved seizures. Clearly, Alexander the Great did not have epilepsy and his name should be removed from the list of famous individuals who have had seizures.

  20. Geohydrology and water-chemistry of the Alexander Valley, Sonoma County, California

    USGS Publications Warehouse

    Metzger, Loren F.; Farrar, Christopher D.; Koczot, Kathryn M.; Reichard, Eric G.

    2006-01-01

    This study of the geohydrology and water chemistry of the Alexander Valley, California, was done to provide an improved scientific basis for addressing emerging water-management issues, including potential increases in water demand and changes in flows in the Russian River. The study tasks included (1) evaluation of existing geohydrological, geophysical, and geochemical data; (2) collection and analysis of new geohydrologic data, including subsurface lithologic data, ground-water levels, and streamflow records; and (3) collection and analysis of new water-chemistry data. The estimated total water use for the Alexander Valley for 1999 was approximately 15,800 acre-feet. About 13,500 acre-feet of this amount was for agricultural use, primarily vineyards, and about 2,300 acre-feet was for municipal/industrial use. Ground water is the main source of water supply for this area. The main sources of ground water in the Alexander Valley are the Quaternary alluvial deposits, the Glen Ellen Formation, and the Sonoma Volcanics. The alluvial units, where sufficiently thick and saturated, comprise the best aquifer in the study area. Average recharge to the Alexander Valley is estimated from a simple, basinwide water budget. On the basis of an estimated annual average of 298,000 acre-feet of precipitation, 160,000 acre-feet of runoff, and 113,000 to 133,000 acre-feet of evapotranspiration, about 5,000 to 25,000 acre-feet per year is available for ground-water recharge. Because this estimate is based on differences between large numbers, there is significant uncertainty in this recharge estimate. Long-term changes in ground-water levels are evident in parts of the study area, but because of the sparse network and lack of data on well construction and lithology, it is uncertain if any significant changes have occurred in the northern part of the study area since 1980. In the southern half of the study area, ground-water levels generally were lower at the end of the 2002 irrigation

  1. von Willebrand Disease (For Parents)

    MedlinePlus

    ... Type 2A or Type 2B. People with Type 3 (and some with Type 2A and 2B) will need treatment with Humate-P, an intravenous medication derived from human plasma that contains factor VIII and von Willebrand factor. ...

  2. The Four Domains of Moral Education: The Contributions of Dewey, Alexander and Goleman to a Comprehensive Taxonomy.

    ERIC Educational Resources Information Center

    Zigler, Ronald Lee

    1998-01-01

    Attempts to place a neglected dimension of John Dewey's work into its proper context. Examines the works of Dewey, F. Matthias Alexander, and Daniel Goldman to create four domains that must be addressed by a truly comprehensive model of moral education: direct external, indirect external, direct internal, and indirect internal. (DSK)

  3. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming’s lucky fungus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been...

  4. Growing Community: The Impact of the Stephanie Alexander Kitchen Garden Program on the Social and Learning Environment in Primary Schools

    ERIC Educational Resources Information Center

    Block, Karen; Gibbs, Lisa; Staiger, Petra K.; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

    2012-01-01

    This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has…

  5. Finding revelation in anthropology: Alexander Winchell, William Robertson Smith and the heretical imperative.

    PubMed

    Livingstone, David N

    2015-09-01

    Anthropological inquiry has often been considered an agent of intellectual secularization. Not least is this so in the sphere of religion, where anthropological accounts have often been taken to represent the triumph of naturalism. This metanarrative, however, fails to recognize that naturalistic explanations could sometimes be espoused for religious purposes and in defence of confessional creeds. This essay examines two late nineteenth-century figures--Alexander Winchell in the United States and William Robertson Smith in Britain--who found in anthropological analysis resources to bolster rather than undermine faith. In both cases these individuals found themselves on the receiving end of ecclesiastical censure and were dismissed from their positions at church-governed institutions. But their motivation was to vindicate divine revelation, in Winchell's case from the physical anthropology of human origins and in Smith's from the cultural anthropology of Semitic ritual.

  6. Neuromusicology or Musiconeurology? "Omni-art" in Alexander Scriabin as a Fount of Ideas.

    PubMed

    Triarhou, Lazaros C

    2016-01-01

    Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872-1915), in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin's "Omni-art" was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image, and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a "higher reality" of which music is only a component. PMID:27014167

  7. Investigation of the Alexander L. Kielland failure-metallurgical and fracture analysis

    SciTech Connect

    Almar-Naess, A.; Haagensen, P.J.; Lian, B.; Moan, T.; Simonsen, T.

    1984-03-01

    On March 27, 1980, the semi-submersible platform Alexander L. Kielland broke down in a storm in the North Sea, resulting in a loss of 123 lives. The investigation subsequently performed by the inquiry commission showed that one of the lower tubular bracings had failed by fatigue. As a result, the vertical leg attached to it was torn off, and the platform capsized. The fatigue fracture had started from a double fillet weld joining a 0.325-m tubular attachment to the bracing. The fillet welds were partially cracked in the early history of the platform due to lammelar tearing. Cumulative damage calculations indicated that the design fatigue life of the bracing was inadequate.

  8. Bryan Coast, English Coast, Alexander Island, Fallieres Coast, and Bellingshausen Sea, Antarctica

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This image of Antarctica shows the Bryan Coast (lower left), the English Coast (lower central), Alexander Island (middle right), the Fallieres Coast (top right), and the Bellingshausen Sea. The entire continent has been dedicated to peaceful scientific investigation since 1961, with the signing of the Antarctic Treaty.The waters surrounding Antarctica are intensely cold. Salt water freezes at -2C, allowing sea ice to form. The middle left portion of the image shows quite a lot of sea ice in the Bellingshausen Sea. During the Antarctic winter, when data for this image was acquired, Antarctica doubles in size to about 28.5 million square km (or about 11 million square miles), and temperatures in the -60C range are common.This true-color image was compiled from MODIS data gathered March 29, 2002. Credit: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

  9. Neuromusicology or Musiconeurology? “Omni-art” in Alexander Scriabin as a Fount of Ideas

    PubMed Central

    Triarhou, Lazaros C.

    2016-01-01

    Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872–1915), in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin’s “Omni-art” was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image, and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a “higher reality” of which music is only a component. PMID:27014167

  10. The name of the father: conflict between Louis and Alexander Agassiz and the Embiotoca surfperch radiation.

    PubMed

    Bernardi, G

    2009-04-01

    The surfperch genus Embiotoca currently comprises two species, Embiotoca jacksoni, the black surfperch, and Embiotoca lateralis, the striped surfperch. Originally, however, Louis Agassiz described a third species in the genus Embiotoca, the rainbow surfperch, Embiotoca caryi. This latter name was changed by Louis' son, Alexander, to Hypsurus caryi, a name that remains valid. In this study, new molecular data (3545 bp of DNA from four mitochondrial and two nuclear DNA regions) indicated that the rainbow surfperch should be retained within the genus Embiotoca, a result consistent with recent morphological data. Adaptive radiation combined with sexual selection resulting in rapid morphological changes in the rainbow surfperch may have contributed to the conflicting position of this species.

  11. Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease

    PubMed Central

    Cotrina, Maria Luisa; Chen, Michael; Han, Xiaoning; Iliff, Jeffrey; Ren, Zeguang; Sun, Wei; Hagemann, Tracy; Goldman, James; Messing, Albee; Nedergaard, Maiken

    2014-01-01

    Alexander disease (AxD) is the only known human pathology caused by mutations in an astrocyte-specific gene, glial fibrillary acidic protein (GFAP). These mutations result in abnormal GFAP accumulations that promote seizures, motor delays and, ultimately, death. The exact contribution of increased, abnormal levels of astrocytic mutant GFAP in the development and progression of the epileptic phenotype is not clear, and we addressed this question using two mouse models of AxD. Comparison of brain seizure activity spontaneously and after traumatic brain injury (TBI), an effective way to trigger seizures, revealed that abnormal GFAP accumulation contributes to abnormal brain activity (increased interictal discharges) but is not a risk factor for the development of epilepsy after TBI. These data highlight the need to further explore the complex and heterogeneous response of astrocytes towards injury and the involvement of GFAP in the progression of AxD. PMID:25069089

  12. Silurian trace fossils in carbonate turbidites from the Alexander Arc of southeastern Alaska

    SciTech Connect

    Soja, C.M. )

    1990-05-01

    Early to Late Silurian (Wenlock-Ludlow) body and trace fossils from the Heceta Formation are preserved in the oldest widespread carbonates in the Alexander terrane of southeastern Alaska. They represent the earliest shelly benthos to inhabit a diversity of marine environments and are important indicators of the early stages in benthic community development within this ancient island arc. The trace fossils are significant because they add to a small but growing body of knowledge about ichnofaunas in deep-water Paleozoic carbonates. Proximal to medial carbonate turbidites yield a low-diversity suite of trace fossils that comprises five distinct types of biogenic structures. Bedding planes reveal simple epichnial burrows (Planolites), cross-cutting burrows (Fucusopsis), and tiny cylindrical burrows. These and other casts, including chondrites( )-like burrow clusters, represent the feeding activities (fodinichnia) of preturbidite animals. Hypichnial burrows and rare endichnial traces reflect the activities of postturbidite animals. Broken and offset traces indicate that infaunal biota commenced burrowing before slumping and subsequent soft-sediment deformation. The abundance and density of trace fossils increases offshore in the medial turbidites associated with a decrease in the size and amount of coarse particles and with an increase in mud and preserved organic material. Although diversity levels are similar in the proximal and medial turbidite facies, they are much lower than in Paleozoic siliciclastic turbidites. This may reflect unfavorable environmental conditions for infaunal biota or paleobiogeographic isolation of the Alexander terrane during the Silurian. A greater use of trace fossils in terrane analysis will help to resolve this issue and should provide new data for reconstructing the paleogeography of circum-Pacific terranes.

  13. Dr. von Braun Briefing Walt Disney

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  14. Reflexionseigenschaften von Windenergieanlagen im Funkfeld von Funknavigations- und Radarsystemen

    NASA Astrophysics Data System (ADS)

    Sandmann, S.; Divanbeigi, S.; Garbe, H.

    2015-11-01

    Die hier behandelte Untersuchung befasst sich mit den Störungen des elektrischen Feldes einer Doppler Very High Frequency Omnidirectional Radio Range Navigationsanlage (DVOR) in der Gegenwart von Windenergieanlagen (WEA). Hierfür wird die Feldstärke auf 25 konzentrischen Kreisbahnen, sog. Orbit Flights verschiedener Höhen und mit verschiedenen Radien rund um die DVOR-Anlage numerisch simuliert. Insbesondere werden die Einflüsse diverser Parameter der WEA wie deren Anzahl, Position, Rotorwinkel, Turmhöhe und Rotordurchmesser auf die Feldverteilung herausgestellt, sowie die Anwendbarkeit der Simulationsmethode Physical Optics (PO) durch Vergleich der Simulationsergebnisse mit denen der Multi Level Fast Multipol Method (MLFMM) untersucht.

  15. "Outstanding Services to Negro Health": Dr. Dorothy Boulding Ferebee, Dr. Virginia M. Alexander, and Black Women Physicians' Public Health Activism.

    PubMed

    Gamble, Vanessa Northington

    2016-08-01

    An examination of the lives and careers of physician-activists Dorothy Boulding Ferebee (1898-1972) and Virginia M. Alexander (1899-1949) demonstrates how Black physicians in the first half of the 20th century used public health to improve the health of Black Americans and provides insights into the experiences of Black women physicians. I discuss their professional and personal backgrounds and analyze their divergent strategies to address health inequities. Ferebee used her leadership in Black women's organizations to develop public health programs and become a national advocate for Black health. Alexander, a Quaker, used her religious connections to urge Whites to combat racism in medicine. She also conducted public health research and connected it to health activism. Both were passionate advocates of health equity long before it gained prominence as a major public health issue. An analysis of their work illuminates past efforts to improve the health of Black Americans.

  16. "Outstanding Services to Negro Health": Dr. Dorothy Boulding Ferebee, Dr. Virginia M. Alexander, and Black Women Physicians' Public Health Activism.

    PubMed

    Gamble, Vanessa Northington

    2016-08-01

    An examination of the lives and careers of physician-activists Dorothy Boulding Ferebee (1898-1972) and Virginia M. Alexander (1899-1949) demonstrates how Black physicians in the first half of the 20th century used public health to improve the health of Black Americans and provides insights into the experiences of Black women physicians. I discuss their professional and personal backgrounds and analyze their divergent strategies to address health inequities. Ferebee used her leadership in Black women's organizations to develop public health programs and become a national advocate for Black health. Alexander, a Quaker, used her religious connections to urge Whites to combat racism in medicine. She also conducted public health research and connected it to health activism. Both were passionate advocates of health equity long before it gained prominence as a major public health issue. An analysis of their work illuminates past efforts to improve the health of Black Americans. PMID:27310348

  17. Putting evo-devo into focus. An interview with Scott F. Gilbert. Interview by Alexander T. Mikhailov.

    PubMed

    Gilbert, Scott F

    2005-01-01

    This article announces Dr. Scott F. Gilbert as the winner of the Alexander Kowavelsky international prize (2004) and briefly reviews his achievements in developmental biology and evo-devo. Dr. Gilbert replies to the interviewer's questions concerning his personal interest in evo-devo and current controversies within the field. His thoughts and comments represent a unique blend of research talents and skills, curiosity and creativity.

  18. Dr. Wernher Von Braun greeting dignitaries.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, left, greets vice president Spiro T. Agnew in the Launch Control Center for the Apollo 14 mission. Between Dr. Von Braun and Mr. Agnew are their Royal Highnesses, The Prince and Princess of Spain. The royal visitors greeted the launch control team in th enter after the launch of Apollo 14.

  19. Dr. Wernher Von Braun at a picnic.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, director of the Marshall Space Flight Center, stakes claim to a table for the picnic celebrating man's first lunar landing. With Dr. Von Braun are his wife, Maria (seated, right), and son, Peter (back to camera). His daughter, Margrit, was also present, but is hidden from view by friends in this view.

  20. Walt Disney and Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

  1. Ludwig von Mises: An Annotated Bibliography.

    ERIC Educational Resources Information Center

    Gordon, David

    A 117-item annotated bibliography of books, articles, essays, lectures, and reviews by economist Ludwig von Mises is presented. The bibliography is arranged chronologicaly, and is followed by an alphabetical listing of the citations, excluding books. An index and information on the Ludwig von Mises Institute at Auburn University (Alabama) are…

  2. James Alexander Lindsay (1856-1931), and his clinical axioms and aphorisms.

    PubMed

    Breathnach, Caoimhghin S; Moynihan, John B

    2012-09-01

    John Alexander Lindsay was born at Fintona, county Tyrone in 1856, and at the age of 23 he graduated in medicine at the Royal University of Ireland. After two years in London and Europe he returned to Belfast to join the staff at the Royal Victoria Hospital and in 1899 he was appointed to the professorship of medicine. He was valued by the students for his clarity and by his colleagues for his many extracurricular contributions to the medical profession in the positions entrusted to him. He published monographs on Diseases of the Lungs, and the Climatic Treatment of Consumption, but his later Medical Axioms show his deep appreciation of studied clinical observation. Although practice was changing in the new century Lindsay displayed an ability to change with the new requirements, as evidenced by his lecture on electrocardiography as president of the section of medicine of the Royal Academy of Medicine in Ireland in 1915. He was impressed by the way the string galvanometer changed attention from stenosis and incompetence of the valves to the cardiac musculature, but rightly suspected that there was more to be told about the state of the myocardium than Einthoven's three leads revealed. His death occurred in Belfast in 1931.

  3. Alexander Scriabin: his chronic right-hand pain and Its impact on his piano compositions.

    PubMed

    Altenmüller, Eckart

    2015-01-01

    Alexander Scriabin was an outstanding pianist and an avant-garde composer who influenced later generations with his innovative "multimedia" conceptions of aesthetic experience. As an adolescent, he was systematically trained as a concert pianist and received lessons from Vassily Safonoff, one of the founders of the legendary Russian Piano School. At age 20, Scriabin suffered an overuse injury of his right hand when attempting to improve the sound quality of his piano touch. This injury caused a deep crisis and influenced his later composition style in his piano works. From this time on, his works were frequently dominated by unusual virtuosic use and wide spans of his left hand. Rest, restricted repertoire, and an increased focus on composition contributed to recovery; however, he always remained anxious concerning the stamina of his right hand. The case report impressively demonstrates the stressors an aspiring young pianist had to cope with at the end of the nineteenth century. Furthermore, it is a convincing example of how resource-oriented behavior and intuition lead to the improvement of health status. Differential diagnoses and the modern concept of multimodal pain therapy in chronic overuse injury will be discussed from a historical perspective. PMID:25684291

  4. James Alexander Lindsay (1856-1931), and his clinical axioms and aphorisms.

    PubMed

    Breathnach, Caoimhghin S; Moynihan, John B

    2012-09-01

    John Alexander Lindsay was born at Fintona, county Tyrone in 1856, and at the age of 23 he graduated in medicine at the Royal University of Ireland. After two years in London and Europe he returned to Belfast to join the staff at the Royal Victoria Hospital and in 1899 he was appointed to the professorship of medicine. He was valued by the students for his clarity and by his colleagues for his many extracurricular contributions to the medical profession in the positions entrusted to him. He published monographs on Diseases of the Lungs, and the Climatic Treatment of Consumption, but his later Medical Axioms show his deep appreciation of studied clinical observation. Although practice was changing in the new century Lindsay displayed an ability to change with the new requirements, as evidenced by his lecture on electrocardiography as president of the section of medicine of the Royal Academy of Medicine in Ireland in 1915. He was impressed by the way the string galvanometer changed attention from stenosis and incompetence of the valves to the cardiac musculature, but rightly suspected that there was more to be told about the state of the myocardium than Einthoven's three leads revealed. His death occurred in Belfast in 1931. PMID:23620615

  5. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming's lucky fungus.

    PubMed

    Henk, D A; Eagle, C E; Brown, K; Van Den Berg, M A; Dyer, P S; Peterson, S W; Fisher, M C

    2011-10-01

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a putatively globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been shown to be genetically diverse, and possess mating-type genes. Here, phylogenetic and population genetic analyses show that this apparently ubiquitous fungus is actually composed of at least two genetically distinct species with only slight differences detected in physiology. We found each species in air and dust samples collected in and around St Mary's Hospital where Fleming worked. Genotyping of 30 markers across the genome showed that preserved fungal material from Fleming's laboratory was nearly identical to derived strains currently in culture collections and in the same distinct species as a wild progenitor strain of current penicillin producing industrial strains rather than the type species P. chrysogenum. Global samples of the two most common species were found to possess mating-type genes in a near 1:1 ratio, and show evidence of recombination with little geographic population subdivision evident. However, no hybridization was detected between the species despite an estimated time of divergence of less than 1MYA. Growth studies showed significant interspecific inhibition by P. chrysogenum of the other common species, suggesting that competition may facilitate species maintenance despite globally overlapping distributions. Results highlight under-recognized diversity even among the best-known fungal groups and the potential for speciation despite overlapping distribution.

  6. Testing the equality of students' performance using Alexander-Govern test with adaptive trimmed means

    NASA Astrophysics Data System (ADS)

    Abdullah, Suhaida; Yahaya, Sharipah Soaad Syed; Yusof, Zahayu Md

    2014-06-01

    Analyzing the equality of independent group has to be done with caution. The classical approaches such as ttest for two groups and analysis of variance (ANOVA) for more than two groups always are favorable selection by researchers. However, sometime these methods were abused by the presence of nonnormality or variance heterogeneity or both. It is known that ANOVA is restricted to the assumptions of normality and homogeneity of variance. In real life data, sometimes these requirements are hard to attain. The Alexander-Govern test with adaptive trimmed mean (AG_atm) is one approach that can be chosen as alternative to the classical tests when their assumptions are violated. In this paper, the performances of AG_atm were compared to the original AG test and ANOVA using simulated and real life data. The simulation study proved that the AG_atm performs better than the original AG test and the classical test. For real life data, student's performance in decision analysis course, measured by final examination score was chosen. Based on the exploratory data analysis, this data found to have problem of nonnormality.

  7. Alexander Scriabin: his chronic right-hand pain and Its impact on his piano compositions.

    PubMed

    Altenmüller, Eckart

    2015-01-01

    Alexander Scriabin was an outstanding pianist and an avant-garde composer who influenced later generations with his innovative "multimedia" conceptions of aesthetic experience. As an adolescent, he was systematically trained as a concert pianist and received lessons from Vassily Safonoff, one of the founders of the legendary Russian Piano School. At age 20, Scriabin suffered an overuse injury of his right hand when attempting to improve the sound quality of his piano touch. This injury caused a deep crisis and influenced his later composition style in his piano works. From this time on, his works were frequently dominated by unusual virtuosic use and wide spans of his left hand. Rest, restricted repertoire, and an increased focus on composition contributed to recovery; however, he always remained anxious concerning the stamina of his right hand. The case report impressively demonstrates the stressors an aspiring young pianist had to cope with at the end of the nineteenth century. Furthermore, it is a convincing example of how resource-oriented behavior and intuition lead to the improvement of health status. Differential diagnoses and the modern concept of multimodal pain therapy in chronic overuse injury will be discussed from a historical perspective.

  8. Dr. Wernher von Braun Laid to Rest

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

  9. Dr. Wernher von Braun In His Office

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. This photo depicts von Braun in his office at MSFC.

  10. Death by polonium-210: lessons learned from the murder of former Soviet spy Alexander Litvinenko.

    PubMed

    McFee, Robin B; Leikin, Jerrold B

    2009-02-01

    The medical response to radiation--whether the result of radiological warfare, terrorist deployment of improvised radiation dispersal weapons, political assassination, occupational or industrial accidents or the medically radiated patient remains one of the least taught among all disciplines within medical education. In the aftermath of 9/11 among medical vulnerabilities to toxicant threats, of all the categories of weapons of mass destruction (WMD)--whether using the CBRNE (chemical, biological, radiological, nuclear, explosive) or NBC (nuclear, biological, chemical) acronym--radiation is the least taught in professional schools, responder cultures or civil preparedness organizations. To date, few health care professionals (HCP) possess the fundamental knowledge or skills to identify and diagnose, let alone treat a radiation victim; this vulnerability made even more obvious in the aftermath of the high profile assassination of former Russian agent Alexander Litvinenko. He was poisoned with Polonium210. Radioactive substances are ubiquitous with radiation sources being in or transported through virtually every region nationwide. It is essential to increase preparedness among community and rural health care facilities as well as urban and university hospitals. Managing radiation injuries effectively requires access to specialized equipment and expertise. Radiation sickness is progressive and may require acute, critical and long-term care throughout the course of illness. Regardless of the source, preparedness rests upon acknowledging a threat exists and dedicating the resources to address the risks including the enhancement of training and equipment. Mass or individual exposures to radiation present unique challenges to the entire response continuum from law enforcement, first responders and emergency medical care. Increased education about and practice in responding to radiological threats is essential to enhance preparedness.

  11. Bathymetric gradients within a Paleozoic Island Arc, southeastern Alaska (Alexander Terrane)

    SciTech Connect

    Soja, C.M. )

    1990-05-01

    Early to Late Silurian (Wenlock-Ludlow) limestones belonging to the Heceta Formation reflect bathymetric gradients within the ancient island arc exposed in the Alexander terrane of southeastern Alaska. These rocks record the earliest occurrence of widespread carbonate deposition in the region and represent the earliest foundation for shallow-water platform development within the arc. The excellent preservation of platform, platform margin, and slope deposits contrasts with the poor preservation of many marine sediments that originated within other island arcs. Hence, these limestones provide important insights into the styles, processes, and bathymetry of carbonate deposition in island arcs. Carbonate depositional sites within the arc extended laterally from nearshore intertidal and relatively shallow subtidal zones of a marine platform, to the seaward margins of a rimmed shelf, and into deeper subtidal areas of a slope environment. Fossiliferous deposits that originated on the platform comprise a diversity of shelly benthos, including corals and stromatoporoids in growth position. Dasycladacean algae, oncoids, and Amphipora also indicate shallow-water conditions. Organic buildups and reefs were constructed by cyanobacteria, massive stromatoporoids, corals, and algae at the platform margin. Deposition beyond the seaward edge of the shelf is evident from the carbonate turbidites that consist of skeletal debris of shallow-water derivation and an absence of coarse siliciclastic detritus. Sedimentation and resedimentation along a bathymetric gradient within the arc is especially well illustrated by the carbonate breccias that are enclosed within these deep subtidal sediments. They comprise detached stromatolites and clasts of shallow-water origin that were derived from the platform and its margin during periodic slumping of the shelf edge.

  12. Project Alexander the Great: a study on the world proliferation of bioengineering/biomedical engineering education.

    PubMed

    Abu-Faraj, Ziad O

    2008-01-01

    Bioengineering/Biomedical Engineering is considered amongst the most reputable fields within the global arena, and will likely be the primer for any future breakthroughs in Medicine and Biology. Bioengineering/biomedical engineering education has evolved since late 1950s and is undergoing advancement in leading academic institutions worldwide. This paper delineates an original study on the world proliferation of bioengineering/biomedical engineering education and bears the name 'Project Alexander the Great'. The initial step of the project was to survey all 10448 universities, recognized by the International Association of Universities, spread among the 193 member states of the United Nations within the six continents. The project aims at identifying, disseminating, and networking, through the world-wide-web, those institutions of higher learning that provide bioengineering/biomedical engineering education. The significance of this project is multifold: i) the inception of a web-based 'world-map' in bioengineering/biomedical engineering education for the potential international student desiring to pursue a career in this field; ii) the global networking of bioengineering/biomedical engineering academic/research programs; iii) the promotion of first-class bioengineering/biomedical engineering education and the catalysis of global proliferation of this field; iv) the erection of bridges among educational institutions, industry, and professional societies or organizations involved in Bioengineering/Biomedical Engineering; and v) the catalysis in the establishment of framework agreements for cooperation among the identified institutions offering curricula in this field. This paper presents the results obtained from Africa and North America. The whole project is due to be completed by 2009.

  13. [Von Hippel-Lindau syndrome].

    PubMed

    Reich, H; Hollwich, F

    1984-06-01

    The von Hippel-Lindau syndrome is an autosomal dominant condition that comprises, apart from angiomas of the retina, the cerebellum, the spinal cord, and the cerebrum, also cystic and blastomatous dysplasias resulting from maldevelopment, namely cystic kidney and pancreas, hypernephroma, and pheochromocytoma. Early observers of the syndrome were the English neurologist John Hughlings Jackson (1872) and the German ophthalmologist Hugo Magnus (1874). The typical association of angiomas of the retina with the cerebellum was first described in 1905 by the Prague ophthalmologist Wilhelm Czermak, long before Lindau (1926). The fact that hypernephromas and pheochromocytomas may form parts of it characterizes the syndrome as a polyneoplastic hereditary disease and the sufferers as members of families at risk. Since the ophthalmologist is often the first to recognize this disease by direct inspection of the fundi, he is responsible for ensuring proper medical care for the affected person and his or her entire family.

  14. Renaturierung und Management von Heiden

    NASA Astrophysics Data System (ADS)

    Härdtle, Werner; Assmann, Thorsten; van Diggelen, Rudy; von Oheimb, Goddert

    Heiden zählen zu den ältesten und besonders reizvollen Kulturlandschaften Nordwesteuropas. Sie sind bezeichnend für nährstoffarme Böden in wintermilden Gebieten mit hohen Sommerniederschlägen. Während Heiden vor wenigen Jahrhunderten noch weit verbreitet und für manche Landschaften sogar prägend waren, hat sich ihr Areal heute auf wenige, meist in Naturschutzgebieten gelegene Restbestände verkleinert. Zu diesem Rückgang haben maßgeblich Änderungen der Landnutzung, aber auch Nährstoffeinträge aus umgebenden Agrarflächen und atmogene Depositionen beigetragen. In den meisten Ländern der Europäischen Union sind Heiden heute gesetzlich geschützte Ökosysteme, da diese, neben ihrem Erholungswert für den Menschen, Pflanzen- und Tierarten beherbergen, die außerhalb von Heiden nicht oder kaum überlebensfähig sind.

  15. Wally Schirra Greets Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Apollo 7 Commander Walter M. Schirra, Jr., left, greets Dr. Wernher Von Braun, Director, Marshall Space Flight Center and Dr. Kurt Debus, Right, KSC Director, during a prelaunch mission briefing held at the Florida Spaceport.

  16. Von Hippel-Lindau Disease (VHL)

    MedlinePlus

    ... Funding Information Research Programs Training & Career Awards Enhancing Diversity Find People About NINDS NINDS Von Hippel-Lindau ... News From NINDS | Find People | Training | Research | Enhancing Diversity Careers@NINDS | FOIA | Accessibility Policy | Contact Us | Privacy ...

  17. Bokan Mountain peralkaline granitic complex, Alexander terrane (southeastern Alaska): evidence for Early Jurassic rifting prior to accretion with North America

    USGS Publications Warehouse

    Dostal, Jaroslav; Karl, Susan M.; Keppie, J. Duncan; Kontak, Daniel J.; Shellnutt, J. Gregory

    2013-01-01

    The circular Bokan Mountain complex (BMC) on southern Prince of Wales Island, southernmost Alaska, is a Jurassic peralkaline granitic intrusion about 3 km in diameter that crosscuts igneous and metasedimentary rocks of the Alexander terrane. The BMC hosts significant rare metal (rare earth elements, Y, U, Th, Zr, and Nb) mineralization related to the last stage of BMC emplacement. U–Pb (zircon) and 40Ar/39Ar (amphibole and whole-rock) geochronology indicates the following sequence of intrusive activity: (i) a Paleozoic basement composed mainly of 469 ± 4 Ma granitic rocks; (ii) intrusion of the BMC at 177 ± 1 Ma followed by rapid cooling through ca. 550 °C at 176 ± 1 Ma that was synchronous with mineralization associated with vertical, WNW-trending pegmatites, felsic dikes, and aegirine–fluorite veins and late-stage, sinistral shear deformation; and (iii) intrusion of crosscutting lamprophyre dikes at >150 Ma and again at ca. 105 Ma. The peralkaline nature of the BMC and the WNW trend of associated dikes suggest intrusion during NE–SW rifting that was followed by NE–SW shortening during the waning stages of BMC emplacement. The 177 Ma BMC was synchronous with other magmatic centres in the Alexander terrane, such as (1) the Dora Bay peralkaline stock and (2) the bimodal Moffatt volcanic suite located ~30 km north and ~100 km SE of the BMC, respectively. This regional magmatism is interpreted to represent a regional extensional event that precedes deposition of the Late Jurassic – Cretaceous Gravina sequence that oversteps the Wrangellia and Alexander exotic accreted terranes and the Taku and Yukon–Tanana pericratonic terranes of the Canadian–Alaskan Cordillera.

  18. Dr. von Braun With German Rocket Experimenters

    NASA Technical Reports Server (NTRS)

    1930-01-01

    Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

  19. Renaturierung von Tagebaufolgeflächen

    NASA Astrophysics Data System (ADS)

    Tischew, Sabine

    Der Abbau von Rohstoffen im Tagebauverfahren bedingt einen tief greifenden Landschafts- und Strukturwandel in den betroffenen Regionen. In der Abbauphase hat vor allem der Braunkohleabbau mit den tagebauübergreifenden Grundwasserabsenkungstrichtern, der Zerstörung oder Beeinträchtigung von ausgedehnten naturnahen Auenökosystemen sowie Wäldern und Elementen der Kulturlandschaft aus der Sicht des Naturschutzes überwiegend negative landschaftsökologische Folgen. Vor allem der Eingriff in Ökosysteme mit langen Entwicklungszeiten (alte Wälder, Moore) oder in die Dynamik von Auensystemen ist nicht oder nur in sehr langen Zeiträumen wieder ausgleichbar. Für letztere ist auch langfristig die Durchgängigkeit für viele Tierarten (Arten der Fließgewässer) nicht wieder vollständig herstellbar. Oft ist es zudem schwierig, traditionelle Landnutzungen (z. B. Wanderschäferei, Nutzung von Streuobstwiesen) nach der langen Abbauphase wieder aufzugreifen. Es ist deshalb eine wichtige Aufgabe, nach dem Abbauprozess auf der Grundlage der vorhandenen Potenziale eine nachhaltige Entwicklung der Bergbaufolgelandschaft zu unterstützen und von den Betreibern des Abbaus und von den Sanierungsgesellschaften auch einzufordern (z. B. Bauer 1998).

  20. The grand experiment, a historical account of a museum/school partnership: The Alexander Science Center School of Los Angeles

    NASA Astrophysics Data System (ADS)

    Heughins, Andrew R.

    This study tells the history of The Alexander Science Center School, a museum/school partnership between the Los Angeles Unified School District and the California Science Center created with the goal of becoming a national model in elementary science education. To provide a background to the development of the school, this study explores the definition of what constitutes a museum school, including the existence of a formal partnership between a school district and a museum and systemic change in the partner institutions leading to a marriage of formal and informal learning styles. In addition, the literature review explores the unique models of museum/school partnerships developed in the United States. The history of the Alexander Science Center School is told in a narrative style using documentation from the schools development and through interviews with individuals who played key roles, from the schools inception through its opening. The study covers the initiation of concept, architectural design, formation of the partnership, and development of the curriculum. The study also identifies the roadblocks encountered in the schools development and makes recommendations for school districts and institutions seeking to create future museum school projects. In addition, a comparison is made other recently studied museum schools to provide a context for the school's historical and programmatic development.

  1. The metallogeny of Late Triassic rifting of the Alexander terrane in southeastern Alaska and northwestern British Columbia

    USGS Publications Warehouse

    Taylor, C.D.; Premo, W.R.; Meier, A.L.; Taggart, J.E.

    2008-01-01

    A belt of unusual volcanogenic massive sulfide (VMS) occurrences is located along the eastern margin of the Alexander terrane throughout southeastern Alaska and northwestern British Columbia and exhibits a range of characteristics consistent with a variety of syngenetic to epigenetic deposit types. Deposits within this belt include Greens Creek and Windy Craggy, the economically most significant VMS deposit in Alaska and the largest in North America, respectively. The occurrences are hosted by a discontinuously exposed, 800-km-long belt of rocks that consist of a 200- to 800-m-thick sequence of conglomerate, limestone, marine elastic sedimentary rocks, and tuff intercalated with and overlain by a distinctive unit of mafic pyroclastic rocks and pillowed flows. Faunal data bracket the age of the host rocks between Anisian (Middle Triassic) and late Norian (late Late Triassic). This metallogenic belt is herein referred to as the Alexander Triassic metallogenic belt. The VMS occurrences show systematic differences in degree of structural control, chemistry, and stratigraphic setting along the Alexander Triassic metallogenic belt that suggest important spatial or temporal changes in the tectonic environment of formation. At the southern end of the belt, felsic volcanic rocks overlain by shallow-water limestones characterize the lower part of the sequence. In the southern and middle portion of the belt, a distinctive pebble conglomerate marks the base of the section and is indicative of high-energy deposition in a near slope or basin margin setting. At the northern end of the belt the conglomerates, limestones, and felsic volcanic rocks are absent and the belt is composed of deep-water sedimentary and mafic volcanic rocks. This northward change in depositional environment and lithofacies is accompanied by a northward transition from epithermal-like structurally controlled, discontinuous, vein- and pod-shaped, Pb-Zn-Ag-Ba-(Cu) occurrences with relatively simple mineralogy

  2. Dr. Wernher Von Braun with Dr. Christian Barnard.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Christian Barnard Tours Marshall Space Flight Center. Shown in Dr. Von Braun's office are (left to right): Dr. Ernst Sthulinger, a representative from General Electric, Dr. Wernher Von Braun, Dr. Christian Barnard, and Dr. Eberhard Rees.

  3. von Braun 1952 Space Station Concept

    NASA Technical Reports Server (NTRS)

    1952-01-01

    This is a von Braun 1952 space station concept. In a 1952 series of articles written in Collier's, Dr. Wernher von Braun, then Technical Director of the Army Ordnance Guided Missiles Development Group at Redstone Arsenal, wrote of a large wheel-like space station in a 1,075-mile orbit. This station, made of flexible nylon, would be carried into space by a fully reusable three-stage launch vehicle. Once in space, the station's collapsible nylon body would be inflated much like an automobile tire. The 250-foot-wide wheel would rotate to provide artificial gravity, an important consideration at the time because little was known about the effects of prolonged zero-gravity on humans. Von Braun's wheel was slated for a number of important missions: a way station for space exploration, a meteorological observatory and a navigation aid. This concept was illustrated by artist Chesley Bonestell.

  4. Dr. Wernher Von Braun talkes with George Hardy.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    George Hardy of the Marshall Space Flight center's Astronautics Laboratory, talks with Dr. Wernher Von Braun (right), deputy associate administrator for planning. Dr. Von Braun was inspecting the mockup of the Saturn workshop during a visit to the Marshall Center. The visit coincided with the 10th anniversary celebration of the center of which Dr. Von Braun was director until March 1, 1970.

  5. Bewertung von Fahrzeuggeräuschen

    NASA Astrophysics Data System (ADS)

    Genuit, Klaus; Schulte-Fortkamp, Brigitte; Fiebig, André; Haverkamp, Michael

    Bei der Wahrnehmung und Beurteilung eines Automobils sind unzählige Merkmale und Eigenschaften von Bedeutung. Dabei können Merkmale objektiv-technisch beschrieben werden, wie Angaben zur Motorisierung, Höchstgeschwindigkeit, Drehmoment, zulässige Zuladung, Verbrauch usw. Daneben sind weitere Eigenschaften von Bedeutung, die sich einer einfachen objektiv-technischen Beschreibung entziehen. Hier sind Begriffe zu nennen, wie Sicherheit, allgemeine Qualitätsanmutung, Design, Ergonomie, Komfort, Haptik, Fahrdynamik, Zuverlässigkeit, die deutlich schwieriger objektiv erfassbar und beschreibbar sind (Abb. 4.1).

  6. Chest wall angiolipoma complicating von Recklinghausen disease.

    PubMed

    Komatsu, Teruya; Takahashi, Koji; Fujinaga, Takuji

    2013-09-01

    We present the case of an 18-year-old man with chest wall angiolipoma and a medical history of von Recklinghausen neurofibromatosis. The chest wall tumor was originally detected during an evaluation for chest pain. For diagnostic and therapeutic purposes, video-assisted thoracoscopic resection was performed, and the tumor was histopathologically confirmed to be an angiolipoma. Chest wall angiolipoma is exceptionally rare. Only two cases have been reported in the English literature, with no reports regarding chest wall angiolipoma in a patient with von Recklinghausen disease.

  7. Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

    PubMed

    Boczek, Nicole J; Sigafoos, Ashley N; Zimmermann, Michael T; Maus, Rachel L; Cousin, Margot A; Blackburn, Patrick R; Urrutia, Raul; Clark, Karl J; Patterson, Marc C; Wick, Myra J; Klee, Eric W

    2016-09-01

    A de novo GFAP variant, p.R376W, was identified in a child presenting with hypotonia, developmental delay, and abnormal brain MRI. Following the 2015 ACMG variant classification guidelines and the functional studies showing protein aggregate formation in vitro, p.R376W should be classified as a pathogenic variant, causative for Alexander disease.

  8. Prevention and Early Intervention: Individual Differences as Risk Factors for the Mental Health of Children. A Festschrift for Stella Chess and Alexander Thomas.

    ERIC Educational Resources Information Center

    Carey, William B., Ed.; McDevitt, Sean C., Ed.

    This collection of essays, in honor of child psychiatry pioneers Stella Chess and Alexander Thomas, focuses on their idea that important life outcomes are the product of ongoing interactions between a child's behavioral style and the complimentarity or lack of fit of the parenting environment. Following an introduction, the remaining chapters are:…

  9. Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

    PubMed

    Boczek, Nicole J; Sigafoos, Ashley N; Zimmermann, Michael T; Maus, Rachel L; Cousin, Margot A; Blackburn, Patrick R; Urrutia, Raul; Clark, Karl J; Patterson, Marc C; Wick, Myra J; Klee, Eric W

    2016-09-01

    A de novo GFAP variant, p.R376W, was identified in a child presenting with hypotonia, developmental delay, and abnormal brain MRI. Following the 2015 ACMG variant classification guidelines and the functional studies showing protein aggregate formation in vitro, p.R376W should be classified as a pathogenic variant, causative for Alexander disease. PMID:27648269

  10. Alexander Graham Bell's Patent for the Telephone and Thomas Edison's Patent for the Electric Lamp. The Constitution Community: The Development of the Industrial United States (1870-1900).

    ERIC Educational Resources Information Center

    Schur, Joan Brodsky

    In 1876 Americans held a Centennial Exhibition in Philadelphia (Pennsylvania) to celebrate the nation's birth 100 years earlier. Machinery Hall drew the most admiration and wonder. Alexander Graham Bell exhibited the first telephone, and Thomas Alva Edison presented the automatic telegraph, one of more than 1,000 inventions he would patent in his…

  11. The Question of Sign-Language and the Utility of Signs in the Instruction of the Deaf: Two Papers by Alexander Graham Bell (1898)

    ERIC Educational Resources Information Center

    Marschark, M.

    2005-01-01

    Alexander Graham Bell is often portrayed as either hero or villain of deaf individuals and the Deaf community. His writings, however, indicate that he was neither, and was not as clearly definite in his beliefs about language as is often supposed. The following two articles, reprinted from The Educator (1898), Vol. V, pp. 3?4 and pp. 38?44,…

  12. Improving Learning Outcomes, Persistence, and Graduation Rates of Academically Underprepared Students: a Case Study of Alexander Community College and Its Developmental Education Effort

    ERIC Educational Resources Information Center

    Marchione, Susan M.

    2012-01-01

    This case study describes how Alexander Community College (ACC), a two-year State University of New York (SUNY) institution is addressing challenges associated with its developmental education effort--primarily high costs for repeated developmental (assumed by the institution and students) and low persistence and graduation rates for developmental…

  13. Discuss: If Essays Are Dead, Then Where Does That Leave Everything Else? A Response to: Shirley Alexander's "Buying Essays: How to Make Sure Assessment Is Authentic"

    ERIC Educational Resources Information Center

    McQueen, Kelvin

    2015-01-01

    Professor Shirley Alexander is the Deputy Vice-Chancellor and Vice-President (Teaching, Learning & Equity) at the University of Technology, Sydney. On 12 November 2014, an article of hers appeared in "The Conversation": "Buying essays: how to make sure assessment is authentic." That article traverses, in an abbreviated way,…

  14. The evolution of ultrahigh carbon steels - from the Great Pyramids, to Alexander the Great, to Y2K

    SciTech Connect

    Wadsworth, J

    1999-10-01

    Hypereutectoid steels containing between about 1 and 2.1 wt%C, and now known as ultrahigh carbon steels (UHCS), have both a rich history (dating back to the time of Alexander the Great, i.e. {approximately} 300 BC) and an interesting, recent, technological period of development (from 1975 to the present). The connections between the modern UHCS and their ancient counterparts, and in particular Damascus steels, have received considerable attention. In addition to monolithic products, UHCS have also been used in both ancient and modern times in laminated composites. In the present paper, a summary of the modern development of UHCS and UHCS-containing laminates is given, and parallels are drawn with ancient materials. Also, ancient laminated composites containing other steels are described; controversial issues and a possible solution related to the age of such a laminate found in the Great Pyramid of Gizeh are discussed.

  15. The appearance of the artist to the people: the creativity, personality and malady of Alexander Ivanov (1806-58).

    PubMed

    Lerner, Vladimir; Witztum, Eliezer

    2005-02-01

    Alexander Ivanov was an outstanding Russian painter who lived in the middle of the nineteenth century, during the romantic period. He did not accept romanticism but instead tried to create his own original style, an ambitious combination of spiritual profundity and a manner of execution unparalleled in Western European art. Ivanov's intention and style are best reflected in his major work The Appearance of Christ to the People, a picture on which he worked for over 20 years. He painted more than 400 sketches of the picture while attempting to bring his masterpiece to perfection. At the end of his life Ivanov became disillusioned, renounced his strong religious conviction and became suspicious. This study examines the influence of his background, life story and personality on the creative process. From a diagnostic perspective, Ivanov's personality featured obsessive, narcissistic and schizoid traits. In his final years he suffered from a delusional disorder. PMID:15682233

  16. Map of glacial limits and possible refugia in the southern Alexander Archipelago, Alaska, during the late Wisconsin glaciation

    USGS Publications Warehouse

    Carrara, Paul E.; Ager, Thomas A.; Baichtal, James F.; VanSistine, D. Paco

    2003-01-01

    During the late Wisconsin glaciation (circa 26,000-13,000 carbon-14 yr BP) the Cordilleran glacier complex formed vast ice fields and large glaciers along the crest of the Coast Mountains. As these glaciers flowed west to the Pacific Ocean, they were joined by local glaciers originating on the higher reaches of the Alexander Archipelago (Mann and Hamiltion, 1995). This extensive volume of ice was channeled into deep troughs (present-day fiords) that formed major outlet glaciers, such as the glaciers that occupied Chatham Strait and Dixon Entrance. In several places along the coast, deep glacially scoured submarine troughs indicate that glaciers reached to the edge of the continental shelf. For instance, the glacier that extended into the Dixon Entrance trough is known to have extended to the edge of the continental shelf. Its retreat began sometime after 16,000-15,000 carbon-14 yr BP (Barrie and Conway, 1999).

  17. James Sowerby: meteorites and his meteoritic sword made for the Emperor of Russia, Alexander I, in 1814

    PubMed Central

    Henderson, Paul

    2013-01-01

    James Sowerby included meteorites in his publications of British and exotic natural history and so raised interest in their nature and origins at a time of much debate and involving the President of the Royal Society, Sir Joseph Banks. The celebrations over the defeat of France in 1814 prompted Sowerby to make a sword from the Cape of Good Hope iron meteorite to present to the Russian Emperor, Alexander I, at the time of his state visit to London in June 1814 and in recognition of his achievements in bringing peace to Europe. The story of its attempted presentation, its final reception and the following response, including publications, all helped to increase interest in meteorites and their properties. The rediscovery of the sword after a lengthy disappearance probably brings an unusual saga to a fitting close.

  18. Untersuchungen zur Entwicklung von Satellitengalaxien

    NASA Astrophysics Data System (ADS)

    Seidel, Björn

    2002-01-01

    Gleichgewichtsmodelle ein- und zweikomponentiger Satellitengalaxien werden erzeugt und die Gezeiteneinwirkungen der als starres äußeres Potential angenommenen Milchstraße auf sie betrachtet. Eine erste Reihe von Simulationen mit anfänglich kugelsymmetrischen einkomponentigen Satelliten zeigt, daß sich nach elliptischer Deformation ein Balken und Schweife ungleicher Länge ausbilden, deren Aussehen sich periodisch ändert. Mithilfe von Vergleichssimulationen wurden folgende Phänomene am Satelliten entdeckt: (1) Hochdichtebereiche in den Schweifen, (2) Niedrigdichtebereiche um den Kern bzw. Balken und (3) ein oft verdeckter Balken. Analysiert wird das Erscheinungsbild in Zeitabhängigkeit. Die Teilchen gehen dem Kern über den Balken verloren und bewegen sich entlang gewisser stets gleich aussehender charakteristischer Strukturen in die Schweife. Nach einer Herleitung allgemeiner Größen des mehrkomponentigen Kingprofils werden drei stabile Standardmodelle zweikomponentiger Satellitengalaxien mit Massenverhältnis 1:10 (baryonische zu dunkle Materie) und unterschiedlicher Verteilung der dunklen und sichtbaren Materie gefunden. Ohne die Allgemeinheit der Ergebnisse zu beeinträchtigen, wurde dabei die Große Magellanische Wolke als Grundlage der Modelle genommen. Nach geeigneter Wahl der Bahn, zu der der Gezeitenradius des verwendeten dreikomponentigen Milchstraßenpotentials sowohl analytisch als auch numerisch berechnet wird, werden Simulationen der Modelle analysiert. Hauptaugenmerk ist das unterschiedliche Verhalten der Komponenten. Hauptergebnisse: (1) Es ist möglich, große Anteile dunkler, jedoch nur geringe sichtbarer Materie abzulösen. Dunkle und sichtbare Materie können unterschiedliche morphologische Strukturen bilden. (2) Je nach Konzentration der Komponenten ist die Eigengravitation der Teilchen mehr oder weniger für das Aussehen bestimmend. (3) Die Kernauflösung des Satelliten findet im Perigalaktikum (PG), sein Zerfall aber erst im

  19. Dr. von Braun Visits Huntsville Boys Club

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

  20. Dr. Wernher Von Braun presents a certificate

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left), director of the Marshall Space Flight Center, presents a humorous certificate to Major General Charles W. Eifler, commanding general of Redstone Arsenal, at the close of a farewell luncheon for the general prior to General Eifler moving to a new European duty station.

  1. Dr. von Braun Discusses 'Bottle Suit' Concept

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a 'bottle suit' model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled 'Man in Space.'

  2. Von Gierke's disease: report of case.

    PubMed

    Cudzinowski, L

    1979-01-01

    Von Gierke's disease, or hepatorenal glycogenesis, type I, presents an interesting challenge to the dental practitioner. Showing an incidence of 1/400,000, it is a fairly rare occurrence. It indicates the importance of proper medical consultation in treating these children, and proper dental treatment and preventive programs to alleviate what could be dangerous for these patients. PMID:289662

  3. Herstellung von Chitosan und einige Anwendungen

    NASA Astrophysics Data System (ADS)

    Struszczyk, Marcin Henryk

    2001-05-01

    1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

  4. A note on derivations of Murray–von Neumann algebras

    PubMed Central

    Kadison, Richard V.; Liu, Zhe

    2014-01-01

    A Murray–von Neumann algebra is the algebra of operators affiliated with a finite von Neumann algebra. In this article, we first present a brief introduction to the theory of derivations of operator algebras from both the physical and mathematical points of view. We then describe our recent work on derivations of Murray–von Neumann algebras. We show that the “extended derivations” of a Murray–von Neumann algebra, those that map the associated finite von Neumann algebra into itself, are inner. In particular, we prove that the only derivation that maps a Murray–von Neumann algebra associated with a factor of type II1 into that factor is 0. Those results are extensions of Singer’s seminal result answering a question of Kaplansky, as applied to von Neumann algebras: The algebra may be noncommutative and may even contain unbounded elements. PMID:24469831

  5. The Cannery Formation--Devonian to Early Permian arc-marginal deposits within the Alexander Terrane, Southeastern Alaska

    USGS Publications Warehouse

    Karl, Susan M.; Layer, Paul W.; Harris, Anita G.; Haeussler, Peter J.; Murchey, Benita L.

    2011-01-01

    cherts on both Admiralty and Kupreanof Islands contain radiolarians as young as Permian, the age of the Cannery Formation is herein extended to Late Devonian through early Permian, to include the early Permian rocks exposed in its type locality. The Cannery Formation is folded and faulted, and its stratigraphic thickness is unknown but inferred to be several hundred meters. The Cannery Formation represents an extended period of marine deposition in moderately deep water, with slow rates of deposition and limited clastic input during Devonian through Pennsylvanian time and increasing argillaceous, volcaniclastic, and bioclastic input during the Permian. The Cannery Formation comprises upper Paleozoic rocks in the Alexander terrane of southeastern Alaska. In the pre-Permian upper Paleozoic, the tectonic setting of the Alexander terrane consisted of two or more evolved oceanic arcs. The lower Permian section is represented by a distinctive suite of rocks in the Alexander terrane, which includes sedimentary and volcanic rocks containing early Permian fossils, metamorphosed rocks with early Permian cooling ages, and intrusive rocks with early Permian cooling ages, that form discrete northwest-trending belts. After restoration of 180 km of dextral displacement of the Chilkat-Chichagof block on the Chatham Strait Fault, these belts consist, from northeast to southwest, of (1) bedded chert, siliceous argillite, volcaniclastic turbidites, pillow basalt, and limestone of the Cannery Formation and the Porcupine Slate of Gilbert and others (1987); (2) greenschist-facies Paleozoic metasedimentary and metavolcanic rocks that have Permian cooling ages; (3) silty limestone and calcareous argillite interbedded with pillow basalt and volcaniclastic rocks of the Halleck Formation and the William Henry Bay area; and (4) intermediate-composition and syenitic plutons. These belts correspond to components of an accretionary complex, contemporary metamorphic rocks, forearc-basin deposits,

  6. From the classical to the generalized von Karman and Marguerre-von Karman equations

    NASA Astrophysics Data System (ADS)

    Ciarlet, Philippe G.; Gratie, Liliana

    2006-06-01

    In this work, we describe and analyze two models that were recently proposed for modeling generalized von Karman plates and generalized Marguerre-von Karman shallow shells.First, we briefly review the "classical" von Karman and Marguerre-von Karman equations, their physical meaning, and their mathematical justification. We then consider the more general situation where only a portion of the lateral face of a nonlinearly elastic plate or shallow shell is subjected to boundary conditions of von Karman type, while the remaining portion is free. Using techniques from formal asymptotic analysis, we obtain in each case a two-dimensional boundary value problem that is analogous to, but is more general than, the classical equations.In particular, it is remarkable that the boundary conditions for the Airy function can still be determined on the entire boundary of the nonlinearly elastic plate or shallow shell solely from the data.Following recent joint works, we then reduce these more general equations to a single "cubic" operator equation, which generalizes an equation introduced by Berger and Fife, and whose sole unknown is the vertical displacement of the shell. We next adapt an elegant compactness method due to Lions for establishing the existence of a solution to this operator equation.

  7. Inattentional blindness and the von Restorff effect.

    PubMed

    Schmidt, Stephen R; Schmidt, Constance R

    2015-02-01

    Sometimes we fail to notice distinctive or unusual items (inattentional blindness), while other times we remember distinctive items more than expected items (the von Restorff effect). A three-factor framework is presented and tested in two experiments in an attempt to reconcile these seemingly contradictory phenomena. Memory for different types of unexpected stimuli was tested after an easy or difficult Stroop color-naming task. Highly arousing taboo words were well remembered even when the difficult Stroop task limited attentional resources. However, a conceptual isolation effect was only observed when the nature of the category change was highlighted by the Stroop task, the Stroop task was easy, and/or the isolated targets enjoyed a retrieval advantage relative to comparison targets. As proposed in the three-factor framework, the arousing qualities of the stimuli, the attentional demands of the primary task, and the relevance of isolated features at encoding and retrieval combine to produce inattentional blindness and the von Restorff effect.

  8. Epithelial cells and Von Gierke's disease.

    PubMed

    Negishi, H; Benke, P J

    1977-08-01

    Epithelial cells and not fibroblasts from human liver and amniotic fluid contain inducible glucose-6-phosphatase (G-6-Pase) activity. The diagnosis of Von Gierke's disease has been made in a patient with hepatomegaly utilizing cultured epithelial cells grown from a liver biopsy. G-6-Pase activity in epithelial cells from this patient could not be induced by dibutyryl cyclic AMP and theophylline. This is the first use of epithelial cells for diagnosis of a metabolic disease. G-6-Pase activity in cloned epithelial cells from amniotic fluid increases 2- to 3-fold after 24-hr exposure to dibutyryl cyclic AMP and theophylline. The prenatal diagnosis of Von Gierke's disease may be possible in a laboratory experienced with these techniques if epithelial cell growth is obtained from amniotic fluid. PMID:196249

  9. The von Nardroff Color Mixing Apparatus

    NASA Astrophysics Data System (ADS)

    Greenslade, Thomas B.

    2005-12-01

    Ernest von Nardroff gave his name to the color mixing apparatus shown in Fig. 1. The basic idea behind this demonstration is to produce three beams of colored light that may be projected onto a white surface. If beams of red, blue, and green are overlapped to produce a figure like a three leaf clover or a Venn diagram, the region of complete overlap will appear white, and the three regions of overlap of two colors produce the three false primaries: yellow, magenta, and cyan. A straightforward technique is to use three slide projectors, each with a colored filter. Von Nardroff's apparatus, displayed at the educational exhibit of Erasmus Hall High School at the Louisiana Purchase Exposition in St. Louis in 1904, permits the use of only one projector.

  10. Herstellung von Chitosan und einige Anwendungen

    NASA Astrophysics Data System (ADS)

    Struszczyk, Marcin Henryk

    2001-05-01

    1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

  11. 2012 ARPA-E Energy Innovation Summit Keynote Presentation (Frederick W. Smith, FedEx Corporation), with Introduction by Senator Lamar Alexander (TN)

    ScienceCinema

    Smith, Frederick W. (FedEx Corporation, Chairman, President and CEO)

    2016-07-12

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Following introduction by Senator Lamar Alexander of Tennessee, Frederick W. Smith, Chairman, President, and CEO of FedEx Corporation, gave the third keynote presentation of the day.

  12. Portrait of Dr. Von Braun with Walt Disney, 1954.

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  13. Using the Alexander Collection to measure the effects of climate change on the grasshoppers of the southern Rocky Mountains of Colorado

    NASA Astrophysics Data System (ADS)

    Nufio, C. R.; Bowers, D. M.; Guralnick, R. P.

    2007-12-01

    The current study utilizes the recently curated and databased Alexander Grasshopper Collection coupled with a new resurvey program to measure the effects of climate change on grasshoppers found along an elevational gradient in the southern Rocky Mountains of Colorado. The Alexander Collection is composed of approximately 19,000 pinned grasshoppers and a series of field data notebooks from a three year 1958-1960 survey project. During these survey years, Alexander processed over 65,000 grasshoppers from repeatedly sampled sites along an elevational gradient from Boulder (1530 m elev.) to Mt Evans (3900m elev.) in the Colorado Front Range. Data from 2006 shows that at mid-elevation sites grasshoppers are becoming adults 15-28 days earlier than they did nearly a half century ago. We found no changes in the time to reach adulthood at the high elevation sites. Preliminary data from 2007 (a year with milder spring temperatures) suggests that unlike the dramatic patterns documented in 2006, that the time to reach adulthood for grasshoppers at low and high elevation sites was not much different than it was 50 years ago. In 2007, several grasshopper species at mid-elevation did become adults earlier than they had a half century ago.

  14. Deficits in Adult Neurogenesis, Contextual Fear Conditioning, and Spatial Learning in a Gfap Mutant Mouse Model of Alexander Disease

    PubMed Central

    Paylor, Richard; Messing, Albee

    2013-01-01

    Glial fibrillary acidic protein (GFAP) is the major intermediate filament of mature astrocytes in the mammalian CNS. Dominant gain of function mutations in GFAP lead to the fatal neurodegenerative disorder, Alexander disease (AxD), which is characterized by cytoplasmic protein aggregates known as Rosenthal fibers along with variable degrees of leukodystrophy and intellectual disability. The mechanisms by which mutant GFAP leads to these pleiotropic effects are unknown. In addition to astrocytes, GFAP is also expressed in other cell types, particularly neural stem cells that form the reservoir supporting adult neurogenesis in the hippocampal dentate gyrus and subventricular zone of the lateral ventricles. Here, we show that mouse models of AxD exhibit significant pathology in GFAP-positive radial glia-like cells in the dentate gyrus, and suffer from deficits in adult neurogenesis. In addition, they display impairments in contextual learning and spatial memory. This is the first demonstration of cognitive phenotypes in a model of primary astrocyte disease. PMID:24259590

  15. Growing community: the impact of the Stephanie Alexander Kitchen Garden Program on the social and learning environment in primary schools.

    PubMed

    Block, Karen; Gibbs, Lisa; Staiger, Petra K; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

    2012-08-01

    This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has a positive impact on student engagement, social connections, and confidence within and beyond the school gates. Primary evidence for the research question came from qualitative data collected from students, parents, teachers, volunteers, school principals, and specialist staff through interviews, focus groups, and participant observations. This was supported by analyses of quantitative data on child quality of life, cooperative behaviors, teacher perceptions of the school environment, and school-level educational outcome and absenteeism data. Results showed that some of the program attributes valued most highly by study participants included increased student engagement and confidence, opportunities for experiential and integrated learning, teamwork, building social skills, and connections and links between schools and their communities. In this analysis, quantitative findings failed to support findings from the primary analysis. Limitations as well as benefits of a mixed-methods approach to evaluation of complex community interventions are discussed.

  16. Listening to the whispers of matter through Arabic hermeticism: new studies on The Book of the Treasure of Alexander.

    PubMed

    Alfonso-Goldfarb, Ana Maria; Jubran, Safa Abou Chahla

    2008-07-01

    The Jabirian Corpus refers to the K. Thahirat Al-'Iskandar, "The Book of the Treasure of Alexander" (hereafter BTA), as one of several forgeries suggesting that alchemical secrets were hidden in inscriptions in various places. The book was neglected until 1926, when Julius Ruska discussed it in his work on the Emerald Tablet, placing the BTA within the literature related to the development of Arabic alchemy. His preliminary study became an essential reference and encouraged many scholars to work on the BTA in the following decades. Some years ago, we completed the first translation of the BTA into a Western language. The work was based on the acephalous Escorial manuscript, which we identified as a fourteenth-century copy of the BTA. This manuscript is peculiar, as part of it is encoded. After finishing our translation, we started to establish the text of the BTA. At present, the text is in process of fixation--to be followed by textual criticism--and has been the main focus of a thorough study of ours on medieval hermeticism and alchemy. A sample of the work currently in progress is presented in this paper: an analysis of the variations between different manuscripts along with a study and English translation of its alchemical chapter. PMID:19048971

  17. Victor or Villain? Wernher von Braun and the Space Race

    ERIC Educational Resources Information Center

    O'Brien, Jason L.; Sears, Christine E.

    2011-01-01

    Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

  18. Group Theoretical Interpretation of von Neumann's Theorem on Composite Systems.

    ERIC Educational Resources Information Center

    Bergia, S.; And Others

    1979-01-01

    Shows that von Neumann's mathematical theorem on composite systems acquires a transparent physical meaning with reference to a suitable physical example; a composite system in a state of definite angular momentum. Gives an outline of the theorem, and the results are restated in Dirac's notation, thus generalizing von Neumann's results which were…

  19. DEBUS, KURT H. AND WERNHER VON BRAUN IN SATURN BLOCKHOUSE

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Cape Kennedy - Dr. Wernher von Braun, director of the National Aeronautics and Space Administration's Marshall Space Flight Center, points to a television screen in the Saturn blockhouse. The screen showed Saturn I vehicle, carrying Pegasus satellite into orbit, during launch. Dr. Kurt Debus, director of NASA's Kennedy Space Center, is seated at Dr. von Braun's right.

  20. Key contributors: Ernst von Glasersfeld's radical constructivism

    NASA Astrophysics Data System (ADS)

    Tobin, Kenneth

    2007-07-01

    This article reviews the significance of the contributions of Ernst von Glasersfeld to research in science education, especially through his theoretical contributions on radical constructivism. As a field shaper, Glasersfeld's subversive ideas catalyzed debate in the science education community and fuelled transformation of many facets including research methods, ways of thinking about teaching and learning, curriculum, and science teacher education. Perturbations emanating from the debates on constructivism forged new pathways that led to the development and use of many of the sociocultural frameworks employed by authors in Cultural Studies of Science Education.

  1. Approximating incompatible von Neumann measurements simultaneously

    SciTech Connect

    Heinosaari, Teiko; Jivulescu, Maria Anastasia; Reitzner, Daniel; Ziman, Mario

    2010-09-15

    We study the problem of performing orthogonal qubit measurements simultaneously. Since these measurements are incompatible, one has to accept additional imprecision. An optimal joint measurement is the one with the least possible imprecision. All earlier considerations of this problem have concerned only joint measurability of observables, while in this work we also take into account conditional state transformations (i.e., instruments). We characterize the optimal joint instrument for two orthogonal von Neumann instruments as being the Lueders instrument of the optimal joint observable.

  2. Renaturierung von Waldökosystemen

    NASA Astrophysics Data System (ADS)

    Zerbe, Stefan

    Wälder sind neben der Landwirtschaft und den urban-industriellen Siedlungsflächen flächenmäßig die Hauptnutzungstypen in Mitteleuropa und stellen heute multifunktionale ökosysteme dar. Zusätzlich zur Holzproduktion kommt ihnen eine Regulations-(z.B.Wasserhaushalt), Schutz (z.B. von Biodiversität und gegen Erosion, Lawinen, Immissionen und Lärm) und Erholungsfunktion zu. Zudem haben Wälder als Kohlenstoffsenken auch eine besondere Bedeutung für den Klimaschutz.

  3. Wernher von Braun and Saturn IB on Launch Pad

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher von Braun stands in front of a Saturn IB launch vehicle at Kennedy Space Flight Center. Dr. von Braun led a team of German rocket scientists, called the Rocket Team, to the United States, first to Fort Bliss/White Sands, later being transferred to the Army Ballistic Missile Agency at Redstone Arsenal in Huntsville, Alabama. They were further transferred to the newly established NASA/Marshall Space Flight Center (MSFC) in Huntsville, Alabama in 1960, and Dr. von Braun became the first Center Director. Under von Braun's direction, MSFC developed the Mercury-Redstone, which put the first American in space; and later the Saturn rockets, Saturn I, Saturn IB, and Saturn V. The Saturn V launch vehicle put the first human on the surface of the Moon, and a modified Saturn V vehicle placed Skylab, the first United States' experimental space station, into Earth orbit. Dr. von Braun was MSFC Director from July 1960 to February 1970.

  4. Report on von Willebrand Disease in Malaysia

    PubMed Central

    Periayah, Mercy Halleluyah; Halim, Ahmad Sukari; Saad, Arman Zaharil Mat; Yaacob, Nik Soriani; Karim, Faraizah Abdul

    2016-01-01

    BACKGROUND: Von Willebrand disease (vWD) is an inherited hemostatic disorder that affects the hemostasis pathway. The worldwide prevalence of vWD is estimated to be 1% of the general population but only 0.002% in Malaysia. AIM: Our present paper has been written to disclose the statistical counts on the number of vWD cases reported from 2011 to 2013. MATERIAL AND METHODS: This article is based on sociodemographic data, diagnoses and laboratory findings of vWD in Malaysia. A total of 92 patients were reported to have vWD in Malaysia from 2011 to 2013. RESULTS: Sociodemographic-analysis revealed that 60% were females, 63% were of the Malay ethnicity, 41.3% were in the 19-44 year old age group and 15.2% were from Sabah, with the East region having the highest registered number of vWD cases. In Malaysia, most patients are predominately affected by vWD type 1 (77.2%). Factor 8, von Willebrand factor: Antigen and vWF: Collagen-Binding was the strongest determinants in the laboratory profiles of vWD. CONCLUSION: This report has been done with great interest to provide an immense contribution from Malaysia, by revealing the statistical counts on vWD from 2011-2013. PMID:27275342

  5. The wounding of Alexander the Great in Cyropolis (329 BC): the first reported case of the syndrome of transient cortical blindness?

    PubMed

    Lascaratos, J

    1997-01-01

    I believe that the transient blindness which presented Alexander the Great after his being wounded on his head and/or his neck by a stone from a catapult during the siege of Cyropolis (329 BC) was in all probability a case of transient cortical blindness that was recognized as a special entity in the 1960s. I reached this conclusion after the comparative study of the Emperor's clinical picture provided by ancient texts, especially those of Plutarch and Quintus Curtius Rufus, with that of a modern medical bibliography.

  6. The Neotropical tanyderid Araucoderus gloriosus (Alexander) (Diptera, Tanyderidae), with description of the egg, larva and pupa, redescription of adults, and notes on natural history.

    PubMed

    Madriz, R Isaí; Courtney, Gregory W

    2016-08-30

    Larvae, pupae and adults of Araucoderus gloriosus (Alexander) were collected during fieldwork in Chilean Patagonia, December 2013 and January 2014. Eggs were obtained from females that oviposited in captivity. Association of all life stages is based on co-occurrence and rearing of individual larvae to adults. A diagnosis for the genus and species is provided. Descriptions of the egg, larva and pupa and redescriptions of the male and female are completed. Eggs of A. gloriosus are the first described for Tanyderidae. Natural history characteristics for this species, including microhabitat, copulatory behavior and oviposition, are discussed.

  7. The Neotropical tanyderid Araucoderus gloriosus (Alexander) (Diptera, Tanyderidae), with description of the egg, larva and pupa, redescription of adults, and notes on natural history.

    PubMed

    Madriz, R Isaí; Courtney, Gregory W

    2016-01-01

    Larvae, pupae and adults of Araucoderus gloriosus (Alexander) were collected during fieldwork in Chilean Patagonia, December 2013 and January 2014. Eggs were obtained from females that oviposited in captivity. Association of all life stages is based on co-occurrence and rearing of individual larvae to adults. A diagnosis for the genus and species is provided. Descriptions of the egg, larva and pupa and redescriptions of the male and female are completed. Eggs of A. gloriosus are the first described for Tanyderidae. Natural history characteristics for this species, including microhabitat, copulatory behavior and oviposition, are discussed. PMID:27615889

  8. Quantenphysik Interferometrie von C70-Molekülen

    NASA Astrophysics Data System (ADS)

    Ziegler, Thomas

    2002-05-01

    Interferenzversuche mit Neutronen und schweren Atomen stellen kein großes Problem mehr dar, selbst die Welleneigenschaften von C60-und C70-Molekülen wurden bereits nachgewiesen. Allerdings stößt man bei der Realisation immer feinerer Gitter mit Gitterkonstanten von etwa 100 nm im Fall dieser Moleküle auf technische Probleme. Wissenschaftlern der Universität Wien ist es jüngst gelungen, ein so genanntes Talbot-Lau-Interferometer zu realisieren und die Welleneigenschaften von C70 mit einer bislang unerreichten Qualität nachzuweisen [1].

  9. Von Neumann's growth model: Statistical mechanics and biological applications

    NASA Astrophysics Data System (ADS)

    De Martino, A.; Marinari, E.; Romualdi, A.

    2012-09-01

    We review recent work on the statistical mechanics of Von Neumann's growth model and discuss its application to cellular metabolic networks. In this context, we present a detailed analysis of the physiological scenario underlying optimality à la Von Neumann in the metabolism of the bacterium E. coli, showing that optimal solutions are characterized by a considerable microscopic flexibility accompanied by a robust emergent picture for the key physiological functions. This suggests that the ideas behind optimal economic growth in Von Neumann's model can be helpful in uncovering functional organization principles of cell energetics.

  10. A von Bertalanffy growth model with a seasonally varying coefficient

    USGS Publications Warehouse

    Cloern, James E.; Nichols, Frederic H.

    1978-01-01

    The von Bertalanffy model of body growth is inappropriate for organisms whose growth is restricted to a seasonal period because it assumes that growth rate is invariant with time. Incorporation of a time-varying coefficient significantly improves the capability of the von Bertalanffy equation to describe changing body size of both the bivalve mollusc Macoma balthicain San Francisco Bay and the flathead sole, Hippoglossoides elassodon, in Washington state. This simple modification of the von Bertalanffy model should offer improved predictions of body growth for a variety of other aquatic animals.

  11. Hermann von Helmholtz and the empiricist vision.

    PubMed

    Turner, R S

    1977-01-01

    The philosophical convictions of Hermann von Helmholtz and the empiricist psychology he developed have been extensively discussed in historical literature. This literature has not usually emphasized the tacti assumptions about human physiology that underlaid these convictions nor the way in which Helmholtz's epistemology served as a methodological directive in his research. Helmholtz assumed nerve transmission between sense organs and the mind to be a passive process. Distortion in stimulus patterns occurs physically in the sense organs, which can therefore be treated through mechanical analogies. Stimuli become converted to the perceptions of consciousness through mental processes that are essentially analogous to conscious, inductive inference and that are therefore susceptible, in principle, to introspective investigation. This view of mental function reflected Helmholtz's intellectual debt to German idealism, especially to the philosophical views of J.G. Fichte.

  12. Hermann von Helmholtz and his students

    NASA Astrophysics Data System (ADS)

    Mulligan, Joseph F.

    1989-01-01

    During the years 1871-1888, when Hermann von Helmholtz was professor of physics at the University of Berlin, physicists from all over the world flocked to Berlin to study and do research with him. Among these were the German physicists Max Planck, Heinrich Kayser, Eugen Goldstein, Wilhelm Wien, and Heinrich Hertz, and Americans Henry Rowland, A. A. Michelson, and Michael Pupin. Examples of Helmholtz's scientific and personal interactions with these students and research associates show why he is justly considered the outstanding physics mentor of the 19th century. Both his ideas and his students played a major role in the development of physics in the late 19th and early 20th centuries.

  13. Correlation of Emkuckfaw Group metagraywackes with the Wedowee Group, Northern Piedmont, Alabama: Implications for the interpretation of the Alexander City fault

    SciTech Connect

    Bieler, D.B. . Geology Dept.)

    1993-03-01

    Recent field studies to clarify stratigraphic relationships between the Elkahatchee Quartz Diorite Gneiss and the Brevard zone lead to the interpretation that part of the Emuckfaw Group is correlative with, and probably structurally continuous with, part of the Wedowee Group. The Josie Leg formation of Bieler and Deininger (1987) is a sequence of metagraywackes and interbedded metapelites; it is here interpreted as a coarse submarine fan facies. The northwestern contact of the unit, frequently mapped as the Alexander City fault, maps into the Wadley Line in the New Site and Daviston quadrangles. The southeastern contact is a sheared contact with structurally overlying migmatitic rocks that include quartzites and calcsilicates. The Josie Leg and Wedowee rocks form a southwesterly plunging synform in which the Elkahatchee lies. Where the contact between the units is gently dipping it is mapped as the Wadley line. Where the contact has been folded and dips steeply, it is highly sheared and is mapped as the Alexander City fault. It is impossible to determine at this time how much the section has been attenuated during the shearing. Although the contact has been interpreted as structural, the data are not unambiguous. The Josie Leg/Wedowee contact may be a stratigraphic contact with the apparent structural discordance reflecting the different mechanical behavior of the contrasting lithologies.

  14. Director von Braun Presents General Medaris With Golf Bag

    NASA Technical Reports Server (NTRS)

    1959-01-01

    Marshall Space Flight Center Director Wernher von Braun presents General J.B. Medaris with a new golf bag. General Medaris, (left) was a Commander of the Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama during 1955 to 1958.

  15. 1. Historic American Buildings Survey David von Riesen, Photographer July ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey David von Riesen, Photographer July 1965 BARRACKS (West), Left - BARRACKS (East), Right (Combined into New Barn) - Fort Larned, Barracks (West), Larned, Pawnee County, KS

  16. 1. Historic American Buildings Survey David von Riesen, Photographer July ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey David von Riesen, Photographer July 1965 BARRACKS (West), Left - BARRACKS (East), Right (Combined into New Barn) - Fort Larned, Barracks (East), Larned, Pawnee County, KS

  17. A proof of von Neumann's postulate in Quantum Mechanics

    SciTech Connect

    Conte, Elio

    2010-05-04

    A Clifford algebraic analysis is explained. It gives proof of von Neumann's postulate on quantum measurement. It is of basic significance to explain the problem of quantum wave function reduction in quantum mechanics.

  18. 33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE PERISCOPE FROM THE CONTROL ROOM AT TEST STAND NO. 1, PEENEMUENDE. - Marshall Space Flight Center, Redstone Rocket (Missile) Test Stand, Dodd Road, Huntsville, Madison County, AL

  19. Dr. Wernher Von Braun examines a ruby crystal.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, and Dr. Eberhard Rees (left), deputy director, technical, examine a ruby crystal used in laser experiments in the Marshall Center's Space Sciences Laboratory.

  20. Computed tomography of the liver in von Gierke's disease.

    PubMed

    Biondetti, P R; Fiore, D; Muzzio, P C

    1980-10-01

    The computed tomography findings in the liver of a patient with von Gierke's disease are presented. Precontrast scans demonstrated diffuse decreased density throughout the liver. In the postcontrast scans, a focal right sided hyperdense area was visualized. PMID:6931833

  1. Dr. von Braun Escorts President Kennedy and Vice President Johnson

    NASA Technical Reports Server (NTRS)

    1962-01-01

    Marshall Space Flight Center Director Dr. Wernher von Braun explains a detail from a Saturn IB mockup and engine to President John F. Kennedy, Vice President Lyndon Johnson and other guests, September 11, 1962.

  2. Wernher von Braun with German Officers and Others

    NASA Technical Reports Server (NTRS)

    1942-01-01

    General Erich Fellgiebel, head of the German Army Information Service during World War II, congratulates members of the von Braun rocket team from Peenemunde for their October 3, 1942 A4 flight. Pictured front center is General Erich Fellgiebel. Shaking hands are General Walter Dornberger (left) and General Janssen, commanding officer of Peenemuende with Rudolph Hermarn to their right. Picture left to right in the back row are Wernher von Braun, Captain Stoelzel, Luftwaffe, and Dr. Gerhard Reisig.

  3. Physik gestern und heute Von der Metallstange zum Hochenergielaser

    NASA Astrophysics Data System (ADS)

    Heering, Peter

    2002-05-01

    Im Mai 1752 wurde in Marly bei Paris auf Anregung des amerikanischen Forschers und Politikers Benjamin Franklin erstmals die elektrische Natur des Blitzes nachgewiesen. Damals beschrieb Franklin auch eine technische Vorrichtung, die als Schutz von Gebäuden vor Blitzschlägen dienen sollte: den Blitzableiter. Diese aus heutiger Sicht scheinbar triviale Vorrichtung wurde aber keineswegs unmittelbar akzeptiert. Und bis heute ist die Forschung zum Schutz von Einrichtungen vor Blitzschlägen nicht abgeschlossen.

  4. Neurological Management of Von Hippel-Lindau Disease.

    PubMed

    Hodgson, Trent S; Nielsen, Sarah M; Lesniak, Maciej S; Lukas, Rimas V

    2016-09-01

    Von Hippel-Lindau disease is a genetic condition due to mutation of the Von Hippel-Lindau gene, which leads to an increased risk in the development of hemangioblastomas of the brain and spinal cord. The pathophysiology of disease and its clinical manifestations, as they pertain to the general neurologist, are discussed. Therapeutic management of central nervous system hemangioblastomas ranging from neurosurgical resection, radiation therapy, and systemic therapies is reviewed. PMID:27564075

  5. [Determination of von Willebrand factor multimers in Mexican population].

    PubMed

    Hernández-Zamora, Edgar; Zavala-Hernández, Cesar; Viveros-Sandoval, Martha Eva; Ochoa-Rico, Angeles; Martínez-Murillo, Carlos; Reyes-Maldonado, Elba

    2014-01-01

    Antecedentes: la enfermedad de von Willebrand es un padecimiento hereditario en el que la estructura, función y concentración del factor de von Willebrand están alteradas y, en consecuencia, también la interacción plaqueta-factor de von Willebrand-endotelio. En México no hay registros epidemiológicos de la enfermedad, sólo se han efectuado algunos estudios aislados desde el punto de vista clínico y hematológico. Material y métodos: estudio retrospectivo efectuado en 155 mexicanos mestizos, 75 de ellos con diagnóstico presuntivo de enfermedad de von Willebrand, 15 con sospecha de hemofilia A y 65 donadores sanos (testigos). Se realizaron pruebas: básicas de coagulación, especiales y de clasificación: análisis de la composición multimérica. Resultados: 15 pacientes se diagnosticaron con hemofilia A; de los 75 sujetos con sospecha de enfermedad de von Willebrand se diagnosticaron 50 de la manera siguiente: tipo 1 (62%), tipo 2 (22%) [subtipos: 2A (14%), 2B (2%) y 2N (6%)] y tipo 3 (16%). Conclusión: el análisis de los multímeros del factor de von Willebrand es un método que cumple con las características adecuadas para el diagnóstico de la enfermedad de von Willebrand, por lo que es necesario implementar esta metodología para su estudio y mejorar su diagnóstico específico.

  6. von Willebrand disease in the developing world.

    PubMed

    Srivastava, Alok

    2005-01-01

    von Willebrand disease (VWD) is considered to be the most common inherited bleeding disorder. Data on its epidemiology and impact in developing countries are limited. The biologic heterogeneity and variable presentation of VWD make diagnosis difficult. Although there is no accurate estimate of the prevalence of VWD in developing countries, available data suggest that the proportion of diagnosed cases is lower than the expected number, often accounting for only 6% to 13% of patients with hereditary bleeding disorders. Although accurate subtyping is often not possible, the number with severe disease tends to be much higher, particularly in those parts of the world where consanguinity is common. Agents used to treat patients with VWD range from plasma to purified factor concentrates. Desmopressin (DDAVP) is commonly used. Preliminary data on molecular genetics suggests that there are significant population differences. There is inadequate awareness of this condition and lack of support for these patients from the health care system in many developing countries. Concerted efforts are needed at the scientific and social levels to improve this situation. PMID:15662614

  7. The von Neumann Triple Point Paradox

    NASA Astrophysics Data System (ADS)

    Sanders, Richard; Tesdall, Allen M.

    We describe the problem of weak shock reflection off a wedge and discuss the triple point paradox that arises. When the shock is sufficiently weak and the wedge is thin, Mach reflection appears to be observed but is impossible according to what von Neumann originally showed in 1943. We summarize some recent numerical results for weak shock reflection problems for the unsteady transonic small disturbance equations, the nonlinear wave system, and the Euler equations. Rather than finding a standard but mathematically inadmissible Mach reflection with a shock triple point, the solutions contain a complex structure: there is a sequence of triple points and supersonic patches in a tiny region behind the leading triple point, with an expansion fan originating at each triple point. The sequence of patches may be infinite, and we refer to this structure as Guderley Mach reflection. The presence of the expansion fans at the triple points resolves the paradox. We describe some recent experimental evidence which is consistent with these numerical findings.

  8. Richard von Volkmann: surgeon and Renaissance man.

    PubMed

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R; Mubarak, Scott J

    2008-02-01

    Richard von Volkmann (1830-1889), one of the most important surgeons of the 19(th) century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867-1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the "antiseptic technique" to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann's contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children's fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics.

  9. Richard von Volkmann: surgeon and Renaissance man.

    PubMed

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R; Mubarak, Scott J

    2008-02-01

    Richard von Volkmann (1830-1889), one of the most important surgeons of the 19(th) century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867-1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the "antiseptic technique" to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann's contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children's fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics. PMID:18196438

  10. Exponential Size Distribution of von Willebrand Factor

    PubMed Central

    Lippok, Svenja; Obser, Tobias; Müller, Jochen P.; Stierle, Valentin K.; Benoit, Martin; Budde, Ulrich; Schneppenheim, Reinhard; Rädler, Joachim O.

    2013-01-01

    Von Willebrand Factor (VWF) is a multimeric protein crucial for hemostasis. Under shear flow, it acts as a mechanosensor responding with a size-dependent globule-stretch transition to increasing shear rates. Here, we quantify for the first time, to our knowledge, the size distribution of recombinant VWF and VWF-eGFP using a multilateral approach that involves quantitative gel analysis, fluorescence correlation spectroscopy, and total internal reflection fluorescence microscopy. We find an exponentially decaying size distribution of multimers for recombinant VWF as well as for VWF derived from blood samples in accordance with the notion of a step-growth polymerization process during VWF biosynthesis. The distribution is solely described by the extent of polymerization, which was found to be reduced in the case of the pathologically relevant mutant VWF-IIC. The VWF-specific protease ADAMTS13 systematically shifts the VWF size distribution toward smaller sizes. This dynamic evolution is monitored using fluorescence correlation spectroscopy and compared to a computer simulation of a random cleavage process relating ADAMTS13 concentration to the degree of VWF breakdown. Quantitative assessment of VWF size distribution in terms of an exponential might prove to be useful both as a valuable biophysical characterization and as a possible disease indicator for clinical applications. PMID:24010664

  11. Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease

    PubMed Central

    Casonato, Alessandra; Cattini, Maria Grazia; Daidone, Viviana; Pontara, Elena; Bertomoro, Antonella; Prandoni, Paolo

    2016-01-01

    Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors. It may be difficult to recognize the different contributions of these anomalies. Here we demonstrate that VWD diagnostics gains from measuring platelet VWF, which can reveal a defective VWF synthesis. Measuring platelet VWF revealed that: severe type 1 VWD always coincided with significantly lower platelet and plasma VWF levels, whereas mild forms revealed low plasma VWF levels associated with low or normal platelet VWF levels, and the latter were associated with a slightly shorter VWF survival; type Vicenza (the archetype VWD caused by a reduced VWF survival) featured normal platelet VWF levels despite significantly reduced plasma VWF levels; type 2B patients could have either normal platelet VWF levels associated with abnormal multimer patterns, or reduced platelet VWF levels associated with normal multimer patterns; type 2A patients could have reduced or normal platelet VWF levels, the former associated mainly with type 2A-I, the latter with type 2A-II; plasma and platelet VWF levels were normal in type 2N, except when the defect was associated with a quantitative VWF mutation. Our findings show that measuring platelet VWF helps to characterize VWD, especially the ambiguous phenotypes, shedding light on the mechanisms underlying the disorder. PMID:27532107

  12. Characterization of aberrant splicing of von Willebrand factor in von Willebrand disease: an underrecognized mechanism.

    PubMed

    Hawke, Lindsey; Bowman, Mackenzie L; Poon, Man-Chiu; Scully, Mary-Frances; Rivard, Georges-Etienne; James, Paula D

    2016-07-28

    Approximately 10% of von Willebrand factor (VWF) gene mutations are thought to alter messenger RNA (mRNA) splicing through disruption of consensus splice sites. This mechanism is likely underrecognized and affected by mutations outside consensus splice sites. During VWF synthesis, splicing abnormalities lead to qualitative defects or quantitative deficiencies in VWF. This study investigated the pathologic mechanism acting in 3 von Willebrand disease (VWD) families with putative splicing mutations using patient-derived blood outgrowth endothelial cells (BOECs) and a heterologous human embryonic kidney (HEK 293(T)) cell model. The exonic mutation c.3538G>A causes 3 in-frame splicing variants (23del, 26del, and 23/26del) which cannot bind platelets, blood coagulation factor VIII, or collagen, causing VWD through dominant-negative intracellular retention of coexpressed wild-type (WT) VWF, and increased trafficking to lysosomes. Individuals heterozygous for the c.5842+1G>C mutation produce exon 33 skipping, exons 33-34 skipping, and WT VWF transcripts. Pathogenic intracellular retention of VWF lacking exons 33-34 causes their VWD. The branch site mutation c.6599-20A>T causes type 1 VWD through mRNA degradation of exon 38 skipping transcripts. Splicing ratios of aberrant transcripts and coexpressed WT were altered in the BOECs with exposure to shear stress. This study provides evidence of mutations outside consensus splice sites disrupting splicing and introduces the concept that VWF splicing is affected by shear stress on endothelial cells. PMID:27317792

  13. Locally Compact Quantum Groups. A von Neumann Algebra Approach

    NASA Astrophysics Data System (ADS)

    Van Daele, Alfons

    2014-08-01

    In this paper, we give an alternative approach to the theory of locally compact quantum groups, as developed by Kustermans and Vaes. We start with a von Neumann algebra and a comultiplication on this von Neumann algebra. We assume that there exist faithful left and right Haar weights. Then we develop the theory within this von Neumann algebra setting. In [Math. Scand. 92 (2003), 68-92] locally compact quantum groups are also studied in the von Neumann algebraic context. This approach is independent of the original C^*-algebraic approach in the sense that the earlier results are not used. However, this paper is not really independent because for many proofs, the reader is referred to the original paper where the C^*-version is developed. In this paper, we give a completely self-contained approach. Moreover, at various points, we do things differently. We have a different treatment of the antipode. It is similar to the original treatment in [Ann. Sci. & #201;cole Norm. Sup. (4) 33 (2000), 837-934]. But together with the fact that we work in the von Neumann algebra framework, it allows us to use an idea from [Rev. Roumaine Math. Pures Appl. 21 (1976), 1411-1449] to obtain the uniqueness of the Haar weights in an early stage. We take advantage of this fact when deriving the other main results in the theory. We also give a slightly different approach to duality. Finally, we collect, in a systematic way, several important formulas. In an appendix, we indicate very briefly how the C^*-approach and the von Neumann algebra approach eventually yield the same objects. The passage from the von Neumann algebra setting to the C^*-algebra setting is more or less standard. For the other direction, we use a new method. It is based on the observation that the Haar weights on the C^*-algebra extend to weights on the double dual with central support and that all these supports are the same. Of course, we get the von Neumann algebra by cutting down the double dual with this unique

  14. Entwicklungsperspektiven von Social Software und dem Web 2.0

    NASA Astrophysics Data System (ADS)

    Raabe, Alexander

    Der Artikel beschäftigt sich zunächst mit dem derzeitigen und zukünftigen Einsatz von Social Software in Unternehmen. Nach dem großen Erfolg von Social Software im Web beginnen viele Unternehmen eigene Social Software-Initiativen zu entwickeln. Der Artikel zeigt die derzeit wahrgenommenen Einsatzmöglichkeiten von Social Software im Unternehmen auf, erörtert Erfolgsfaktoren für die Einführung und präsentiert mögliche Wege für die Zukunft. Nach der Diskussion des Spezialfalles Social Software in Unternehmen werden anschließend die globalen Trends und Zukunftsperspektiven des Web 2.0 in ihren technischen, wirtschaftlichen und sozialen Dimensionen dargestellt. Wie aus den besprochenen Haupttrends hervorgeht, wird die Masse an digital im Web verfügbaren Informationen stetig weiterwachsen. So stellt sich die Frage, wie es in Zukunft möglich sein wird, die Qualität der Informationssuche und der Wissensgenerierung zu verbessern. Mit dem Einsatz von semantischen Technologien im Web wird hier eine revolutionäre Möglichkeit geboten, Informationen zu filtern und intelligente, gewissermaßen verstehende" Anwendungen zu entwerfen. Auf dem Weg zu einem intelligenten Web werden sich das Semantic Web und Social Software annähern: Anwendungen wie Semantic Wikis, Semantic Weblogs, lightweight Semantic Web-Sprachen wie Microformats oder auch kommerzielle Angebote wie Freebase von Metaweb werden die ersten Vorzeichen einer dritten Generation des Webs sein.

  15. Biographical sketch: Georg Hermann von Meyer (1815-1892).

    PubMed

    Skedros, John G; Brand, Richard A

    2011-11-01

    This biographical sketch on Georg Hermann von Meyer highlights the interactions in the 1860s that von Meyer, a famous anatomist, had with Karl Culmann, a famous structural engineer and mathematician. The published papers from this interaction caught the attention of Julius Wolff and stimulated his development of the trajectorial hypothesis of bone adaptation--now called "Wolff's Law." The corresponding translations are provided: (1) von Meyer's 1867 paper that highlights the regularity of arched trabecular patterns in various human bones, and his discussions with Culmann about their possible mechanical relevance; and (2) Wolff's 1869 paper that first mentions the correspondence of stress trajectories in a solid, crane-like structure to the arched trabecular patterns in the proximal human femur. This biographical sketch on Georg Hermann von Meyer corresponds to the historic texts, The Classic: The Architecture of the Trabecular bone (by von Meyer), and The Classic: On the Significance of the Architecture of the Spongy Substance for the Question of Bone Growth. A preliminary publication (by Wolff) available at DOIs 10.1007/s11999-011-2041-5 , 10.1007/s11999-011-2042-4 . PMID:21901583

  16. Gunther von Hagens' BODY WORLDS: selling beautiful education.

    PubMed

    Burns, Lawrence

    2007-04-01

    In the BODY WORLDS exhibitions currently touring the United States, Gunther von Hagens displays human cadavers preserved through plastination. Whole bodies are playfully posed and exposed to educate the public. However, the educational aims are ambiguous, and some aspects of the exhibit violate human dignity. In particular, the signature cards attached to the whole-body plastinates that bear the title, the signature of Gunther von Hagens, and the date of creation mark the plastinates as artwork and von Hagens as the artist in a gesture that strips the personal dignity from the donors. I conclude that the educational use of cadavers is compatible with respect for dignity if: 1) the utility of such use is great enough; 2) there are no other ways of achieving these ends; and 3) every effort is made to honor the dignity of the donors.

  17. Renaturierung von subalpinen und alpinen Ökosystemen

    NASA Astrophysics Data System (ADS)

    Krautzer, B.; Klug, Brigitte

    Die große Vielfalt an alpinen und subalpinen Ökosystemen auf waldfreien Standorten stellt besonders hohe Anforderungen an Planung und Durchführung von Renaturierungsmaßnahmen. Zunehmende Meereshöhe, starke Hangneigungen und extreme klimatische Verhältnisse im Gebirge bedingen zudem seit jeher natürliche Erosionsprozesse. Die zahllosen menschlichen Aktivitäten der letzten Jahrzehnte, gepaart mit unzureichenden Begrünungsmaßnahmen, erhöhen dieses Risiko noch um ein Vielfaches: Geländekorrekturen im Zuge von Skipistenbauten, Almrevitalisierungen, Forst- und Almwegebauten, Maßnahmen zur Verbesserung der touristischen Infrastruktur oder Wildbach- und Lawinenverbauungen. Nur durch Verwendung von hochwertigem, dem Standort angepasstem Pflanzen-oder Saatgutmaterial in Kombination mit der passenden Begrünungstechnik kann dieser Bedrohung dauerhaft entgegengewirkt werden. Dabei sind folgende limitierende Faktoren besonders zu beachten.

  18. Asymptotic structure of free product von Neumann algebras

    NASA Astrophysics Data System (ADS)

    Houdayer, Cyril; Ueda, Yoshimichi

    2016-11-01

    Let $(M, \\varphi) = (M_1, \\varphi_1) \\ast (M_2, \\varphi_2)$ be the free product of any $\\sigma$-finite von Neumann algebras endowed with any faithful normal states. We show that whenever $Q \\subset M$ is a von Neumann subalgebra with separable predual such that both $Q$ and $Q \\cap M_1$ are the ranges of faithful normal conditional expectations and such that both the intersection $Q \\cap M_1$ and the central sequence algebra $Q' \\cap M^\\omega$ are diffuse (e.g. $Q$ is amenable), then $Q$ must sit inside $M_1$. This result generalizes the previous results of the first named author in [Ho14] and moreover completely settles the questions of maximal amenability and maximal property Gamma of the inclusion $M_1 \\subset M$ in arbitrary free product von Neumann algebras.

  19. Einblicke in die Dynamik von Quantensystemen: Elektrostatische Speicherringe

    NASA Astrophysics Data System (ADS)

    Welsch, Carsten P.

    2005-03-01

    Elektrostatische Speicherringe kombinieren die Vorteile elektrostatischer Fallen und klassischer magnetischer Speicherringe. Kompaktheit, gute Zugänglichkeit sämtlicher Elemente, hohe Flexibilität in der Wahl möglicher Experimente und die Eigenschaft, alle Teilchen unabhängig von ihrer Masse über einen weiten Geschwindigkeitsbereich zu speichern, bieten Zugang zu einem weiten experimentellen Spektrum. Insbesondere das Potenzial, das in neuartigen, energievariablen Maschinen in Kombination mit Elektronenkühlung, internen Targets und hochauflösenden Reaktionsmikroskopen steckt, verspricht hochinteressante Ergebnisse mit den unterschiedlichsten Teilchen - von exotischen Antiprotonen oder schweren radioaktiven Ionen bis hin zu einfachen und komplexen Molekülen oder Biosystemen.

  20. The smooth entropy formalism for von Neumann algebras

    NASA Astrophysics Data System (ADS)

    Berta, Mario; Furrer, Fabian; Scholz, Volkher B.

    2016-01-01

    We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

  1. Henry Cavendish, Johann von Soldner, and the deflection of light

    NASA Astrophysics Data System (ADS)

    Will, Clifford M.

    1988-05-01

    The gravitational deflection of light based on Newtonian theory and the corpuscular model of light was calculated, but never published, around 1784 by Henry Cavendish, almost 20 years earlier than the first published calculation by Johann Georg von Soldner. The two results are slightly different because, while Cavendish treated a light ray emitted from infinity, von Soldner treated a light ray emitted from the surface of the gravitating body. At the first order of approximation, they agree with each other; both are one-half the value predicted by general relativity and confirmed by experiment.

  2. Renaturierung von Fließgewässern

    NASA Astrophysics Data System (ADS)

    Lüderitz, Volker; Jüpner, Robert

    Beim Umgang mit den Gewässern wurde der wasserbaulichen Durchsetzung bestimmter Nutzungsansprüche, vor allem der Landwirtschaft, dem Hochwasserschutz, der Wassergewinnung, der Schifffahrt und der Energiegewinnung über Jahrhunderte absoluter Vorrang vor den Belangen des ökologischen Zustandes der Gewässer selbst und damit auch ihrer multifunktionalen Nutzbarkeit eingeräumt. Die daraus resultierenden Umweltauswirkungen wurden oft billigend in Kauf genommen. Gezielte Verbesserungen der ökologischen Situation von Gewässern bzw. Gewässerabschnitten, wie z.B. der Einsatz ingenieurbiologischer Bauweisen oder der Einbau von Fischwanderhilfen an Mühlenstauen, blieben auf Ausnahmen beschränkt.

  3. An Accurate von Neumann's Law for Three-Dimensional Foams

    SciTech Connect

    Hilgenfeldt, Sascha; Kraynik, Andrew M.; Koehler, Stephan A.; Stone, Howard A.

    2001-03-19

    The diffusive coarsening of 2D soap froths is governed by von Neumann's law. A statistical version of this law for dry 3D foams has long been conjectured. A new derivation, based on a theorem by Minkowski, yields an explicit analytical von Neumann's law in 3D which is in very good agreement with detailed simulations and experiments. The average growth rate of a bubble with F faces is shown to be proportional to F{sup 1/2} for large F , in contrast to the conjectured linear dependence. Accounting for foam disorder in the model further improves the agreement with data.

  4. Pseudotumour of the Mandible Associated with von Willebrand's Disease.

    PubMed

    Daniel Sathiya, S S; Pari Selvakumar, P; Singh, Mandeep; Abraham, Aby; Koshy, Santosh

    2015-03-01

    Patients with bleeding disorders may occasionally present with pseudotumours. Most commonly these occur in the soft tissues and long bones, and are very rare in the maxillofacial region. We present the clinical details and management of a pseudotumour of the mandible in a 12-year-old girl with von Willebrand's disease.

  5. Treasure in the Library Attic: Von Ranke at Syracuse.

    ERIC Educational Resources Information Center

    Coville, Bruce

    1984-01-01

    Traces history of private library of German scholar, Leopold von Ranke, which was purchased by Syracuse University in 1888. Efforts of librarian Charles W. Bennett in 1870s and Professor James Powell beginning in late 1960s, and restoration and cataloging of collection are highlighted. Items from the collection are noted. (EJS)

  6. Dr. Wernher Von Braun near the mobile launcher.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

  7. Dr. Wernher Von Braun with Congressman Gerald R. fod

    NASA Technical Reports Server (NTRS)

    1999-01-01

    On a visit to the Marshall Space Flight Center in April, 1964, Congressman Gerald R. Ford, Jr. Republican of Michigan, was warmly greeted by Dr. Wernher Von Braun, Marshall Space Flight Center director. Ford, along with two other congressmen, visited the center for a briefing on the Saturn program and for a tour of the facilities.

  8. Dr. von Braun With a Model of a Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

  9. Anaesthesia in Von Gierke's disease. Current approach to management.

    PubMed

    Bevan, J C

    1980-07-01

    A case report of a patient with Von Gierke's (glycogen storage disease Cori type (1)1 disease who required femoral osteotomy is presented. Current techniques of management of this condition which are likely to improve the outcome of general anaesthesia and surgery are discussed. PMID:6933867

  10. Von Kármán between Aachen and Pasadena

    NASA Astrophysics Data System (ADS)

    Krause, Egon; Kalkmann, Ulrich

    2013-05-01

    In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

  11. Renaturierung von Sandökosystemen im Binnenland

    NASA Astrophysics Data System (ADS)

    Schwabe-Kratochwil, Angelika; Kratochwil, Anselm

    Das Vorkommen von Sandökosystemen im Binnenland (Flugsand- und Decksandfelder, Dünen) ist vor allem an Sand-Akkumulationen der vorletzten Eiszeit (in Nordeuropa: Saaleeiszeit und Sand-Ablagerungen an größeren Flüssen gebunden. So finden wir die Verbreitungsschwerpunkte von binnenländischen Sandökosystemen in Mitteleuropa einerseits vor allem im Bereich der flächenhaften saalezeitlichen Ablagerungen in den Niederlanden und in Norddeutschland (Castel et al. 1989), andererseits kommen Sandökosysteme des Binnenlandes linear in den Flussgebieten z.B. von Maas, Rhein, Ems, Elbe, Oder und Regnitz vor. In Niederösterreich fanden sich einst großflächige Dünen- und Flugsandgebiete im Marchfeld östlich von Wien (Wiesbauer et al. 1997). Die Flugsandbildung setzte bereits im Spätglazial ca. 11000 v. Chr. ein, als eine den Sand fixierende Vegetation noch fehlte. Es bildeten sich im norddeutschen Raum aus den leicht verwehbaren Talsanden bereits um 9000 v. Chr.

  12. The education of Ehrenfried Walther von Tschirnhaus (1651-1708).

    PubMed

    Adler, Jacob

    2015-02-01

    Ehrenfried Walther von Tschirnhaus, mathematician, inventor, and correspondent of Spinoza, is often thought to have studied medicine at Leiden, though documentation of this fact has been lacking. Tschirnhaus' medical education is here documented, along with the nature of his medical practice. PMID:24585587

  13. Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure

    ERIC Educational Resources Information Center

    Joldersma, Clarence W.

    2011-01-01

    In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

  14. Wernher von Braun: Reflections on His Contributions to Space Exploration

    NASA Technical Reports Server (NTRS)

    Goldman, Arthur E.

    2012-01-01

    In 1950, Dr. Wernher von Braun and approximately 100 of his team members came to Huntsville, Alabama, to begin work with the Army on what would later become America's historic space program. He would later serve as the first director of the Marshall Space Flight Center and led the development of the Saturn V launch vehicle that launched seven crewed American mission to the moon, as well as America s first space station, Skylab. Von Braun is best known for his team s technical achievements. He realized his dream of exploring outer space by helping place humans on the moon. His engineering and managerial talent during the Apollo era had contributed to a technological revolution. He was by all accounts a good engineer, but he was only one among many. What set Von Braun apart were his charisma, his vision, and his leadership skills. He inspired loyalty and dedication in the people around him. He understood the importance of communicating his vision to his team, to political and business leaders and the public. Today, the Marshall Center continues his vision by pursuing engineering and scientific projects that will continue to open space to exploration. This presentation will discuss Von Braun's impact on Huntsville, the Marshall Center, the nation and the world and look at his contributions in context of where world space exploration is today.

  15. The education of Ehrenfried Walther von Tschirnhaus (1651-1708).

    PubMed

    Adler, Jacob

    2015-02-01

    Ehrenfried Walther von Tschirnhaus, mathematician, inventor, and correspondent of Spinoza, is often thought to have studied medicine at Leiden, though documentation of this fact has been lacking. Tschirnhaus' medical education is here documented, along with the nature of his medical practice.

  16. Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease.

    PubMed Central

    Levene, R B; Booyse, F M; Chediak, J; Zimmerman, T S; Livingston, D M; Lynch, D C

    1987-01-01

    Studies were conducted to characterize the biosynthesis of von Willebrand factor (vWf) by cultured endothelial cells (EC) derived from the umbilical vein of a patient with type IIA von Willebrand disease. The patient's EC, compared with those from normal individuals, produced vWf that had decreased amounts of large multimers and an increase in rapidly migrating satellite species, features characteristic of plasma vWf from patients with type IIA von Willebrand disease. The type IIA EC did produce a full spectrum of vWf multimers in both cell lysates and postculture medium, although the relative amounts of the largest species were decreased. The large multimers were degraded in conjunction with the appearance of rapidly migrating satellites that contained approximately equal to 170-kDa proteolytic fragments, suggesting that this patient's functional defect is due to abnormal proteolysis and not to a primary failure of vWf subunit oligomerization. Moreover, the observed degradation appears to result from an abnormal vWf molecule and not elevated protease levels. These results suggest that this patient's von Willebrand disease phenotype is caused by increased proteolytic sensitivity of his vWf protein. Images PMID:3306682

  17. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease

    PubMed Central

    Gill, Joan C.; Castaman, Giancarlo; Windyga, Jerzy; Kouides, Peter; Ragni, Margaret; Leebeek, Frank W. G.; Obermann-Slupetzky, Ortrun; Chapman, Miranda; Fritsch, Sandor; Pavlova, Borislava G.; Presch, Isabella

    2015-01-01

    This phase 3 trial evaluated the safety and hemostatic efficacy of a recombinant von Willebrand factor (rVWF) for treatment of bleeds in severe von Willebrand disease (VWD). rVWF was initially administered together with recombinant factor VIII (rFVIII) and subsequently alone, as long as hemostatic factor VIII activity (FVIII:C) levels were maintained. Pharmacokinetics (PK) were evaluated in a randomized cross-over design (rVWF vs rVWF:rFVIII at 50 IU VWF:ristocetin cofactor activity [RCo]/kg). Bleed control for all treated bleeds (N = 192 bleeds in 22 subjects) was rated good or excellent (96.9% excellent; 119 of 122 minor, 59 of 61 moderate, and 6 of 7 major bleeds) on a 4-point scale (4 = none to 1 = excellent). A single infusion was effective in 81.8% of bleeds. Treatment success, defined as the number of subjects with a mean efficacy rating of <2.5, was 100%. The PK profile of rVWF was not influenced by rFVIII (mean VWF:RCo terminal half-life: 21.9 hours for rVWF and 19.6 hours for rVWF:rFVIII). FVIII:C levels increased rapidly after rVWF alone, with hemostatic levels achieved within 6 hours and sustained through 72 hours after infusion. Eight adverse events (AEs; 6 nonserious AEs in 4 subjects and 2 serious AEs [chest discomfort and increased heart rate, without cardiac symptomatology] concurrently in 1 subject) were associated with rVWF. There were no thrombotic events or severe allergic reactions. No VWF or FVIII inhibitors, anti-VWF binding antibodies, or antibodies against host cell proteins were detected. These results show that rVWF was safe and effective in treating bleeds in VWD patients and stabilizes endogenous FVIII:C, which may eliminate the need for rFVIII after the first infusion. This trial was registered at www.clinicaltrials.gov as #NCT01410227. PMID:26239086

  18. Post-traumatic stress reactions before the advent of post-traumatic stress disorder: potential effects on the lives and legacies of Alexander the Great, Captain James Cook, Emily Dickinson, and Florence Nightingale.

    PubMed

    Mackowiak, Philip A; Batten, Sonja V

    2008-12-01

    Evidence is presented that Alexander the Great, Captain James Cook, Emily Dickinson, and Florence Nightingale each developed symptoms consistent with post-traumatic stress disorder in the aftermath of repeated potentially traumatizing events of differing character. Their case histories also varied with respect to background, premorbid personality style, risk factors, clinical presentation, and course of the illness, illustrating the pleomorphic character of the disorder, as well as the special problems in diagnosing it in historical figures.

  19. Post-traumatic stress reactions before the advent of post-traumatic stress disorder: potential effects on the lives and legacies of Alexander the Great, Captain James Cook, Emily Dickinson, and Florence Nightingale.

    PubMed

    Mackowiak, Philip A; Batten, Sonja V

    2008-12-01

    Evidence is presented that Alexander the Great, Captain James Cook, Emily Dickinson, and Florence Nightingale each developed symptoms consistent with post-traumatic stress disorder in the aftermath of repeated potentially traumatizing events of differing character. Their case histories also varied with respect to background, premorbid personality style, risk factors, clinical presentation, and course of the illness, illustrating the pleomorphic character of the disorder, as well as the special problems in diagnosing it in historical figures. PMID:19149331

  20. The question of sign-language and the utility of signs in the instruction of the deaf: two papers by Alexander Graham Bell (1898).

    PubMed

    Bell, Alexander Graham

    2005-01-01

    Alexander Graham Bell is often portrayed as either hero or villain of deaf individuals and the Deaf community. His writings, however, indicate that he was neither, and was not as clearly definite in his beliefs about language as is often supposed. The following two articles, reprinted from The Educator (1898), Vol. V, pp. 3-4 and pp. 38-44, capture Bell's thinking about sign language and its use in the classroom. Contrary to frequent claims, Bell does not demand "oral" training for all deaf children--even if he thinks it is the superior alternative--but does advocate for it for "the semi-deaf" and "the semi-mute." "In regard to the others," he writes, "I am not so sure." Although he clearly voices his support for oral methods and fingerspelling (the Rochester method) over sign language, Bell acknowledges the use and utility of signing in a carefully-crafted discussion that includes both linguistics and educational philosophy. In separating the language used at home from that in school and on the playground, Bell reveals a far more complex view of language learning by deaf children than he is often granted. (M. Marschark). PMID:15778208

  1. The question of sign-language and the utility of signs in the instruction of the deaf: two papers by Alexander Graham Bell (1898).

    PubMed

    Bell, Alexander Graham

    2005-01-01

    Alexander Graham Bell is often portrayed as either hero or villain of deaf individuals and the Deaf community. His writings, however, indicate that he was neither, and was not as clearly definite in his beliefs about language as is often supposed. The following two articles, reprinted from The Educator (1898), Vol. V, pp. 3-4 and pp. 38-44, capture Bell's thinking about sign language and its use in the classroom. Contrary to frequent claims, Bell does not demand "oral" training for all deaf children--even if he thinks it is the superior alternative--but does advocate for it for "the semi-deaf" and "the semi-mute." "In regard to the others," he writes, "I am not so sure." Although he clearly voices his support for oral methods and fingerspelling (the Rochester method) over sign language, Bell acknowledges the use and utility of signing in a carefully-crafted discussion that includes both linguistics and educational philosophy. In separating the language used at home from that in school and on the playground, Bell reveals a far more complex view of language learning by deaf children than he is often granted. (M. Marschark).

  2. Generalized rainbows and unfolded glories of oblate drops: organization for multiple internal reflections and extension of cusps into Alexander's dark band.

    PubMed

    Marston, P L; Kaduchak, G

    1994-07-20

    Oblate drops of water can produce caustics where, unlike a simple Airy caustic, more than two rays merge. We extend previous treatments of generalized primary rainbows based on catastrophe optics [Opt. Lett. 10, 588 (1985); Proc. R. Soc. (London) A 438, 397 (1992)] to rays having (p - 1) = 2 to 5 internal reflections. The analysis is for a horizontally illuminated ellipsoid with a vertical symmetry axis. Aspect ratios causing a vanishing of the vertical curvature at the equator for the outgoing wave front are found from generalized ray tracing. In response to infinitesimal deformation, the axial caustic of real glory rays unfolds producing cusps. Laboratory observations with laser illumination demonstrate that cusps resulting from rays with five internal reflections extend into Alexander's dark band when the drop's aspect ratio is near 1.08. The evolution of this p = 6 scattering pattern as cusps meet the quinary rainbow is suggestive of an E(6) catastrophe. For ellipsoids of varying aspect ratio and refractive index N, there is an organizing singularity associated with an exceptionally flat outgoing wave front from spheres with N = p. PMID:20935841

  3. Bleeding in renal failure: is von Willebrand factor implicated?

    PubMed Central

    Remuzzi, G; Livio, M; Roncaglioni, M C; Mecca, G; Donati, M B; de Gaetano, G

    1977-01-01

    Normal or increased concentrations of factor VIII procoagulant activity (VIIIC), factor VIII-related antigen (VIIIRA), and factor VIII-von Willebrand activity (VIIIVWF) were found in the predialysis plasma of 10 out of 11 patients with chronic renal failure (CRF). All patients had a bleeding time longer than 15 minutes and platelet retention to glass beads lower than 40%. The only patient who had reduced concentrations of all three factor VIII complex components was subsequently shown to have von Willebrand's disease. In four patients with CRF, very low platelet retention, and slightly prolonged bleeding time none of the three factor VIII COMPLEX COMPONENTS WERE SELECTIVely modified in predialysis samples. These findings suggest that the bleeding tendency common in CRF is not necessarily linked to defective plasma factor VIII-related activities. PMID:302134

  4. Marshall-Stickler phenotype associated with von Willebrand disease

    SciTech Connect

    MacDonald, M.R.; Baker, K.S.; Schaefer, G.B.

    1997-01-20

    We report on 6 individuals from three different kindreds with Marshall-Stickler (MS) phenotype, with characteristic orofacial abnormalities, arthropathy, deafness, and eye findings, all of whom were discovered to have a mild bleeding diathesis and coagulation-study findings consistent with mild von Willebrand disease (vWD). MS syndrome has been linked in some cases to the type II procollagen gene (COL2A1) on chromosome 12q, and to the collagen XI gene (COL11A2) on chromosome 6. The von Willebrand factor (vWF) is encoded by a 180-Kb gene located on the short arm of chromosome 12. This is the first reported association of these two disorders. 26 refs., 5 figs., 1 tab.

  5. Lipid storage myopathy in von Gierke's disease: a case report.

    PubMed

    Yamaguchi, K; Santa, T; Inoue, K; Omae, T

    1978-09-01

    An 18-year-old girl with von Gierke's disease associated with a lipid storage myopathy is reported. The diagnosis of von Gierke's disease was made from decreased activity in glucose-6-phosphatase in the jejunal biopsy specimen. Neurologically she showed generalized hypotonia of the muscles, atrophy of bilateral proximal muscles of the lower extremities, weakness in neck flexors, deltoid and lumbar girdle muscles, and a positive Gower's sign. Muscle biopsy from flexor femoris muscle revealed fatty deposition in type 1 fibers and atrophy of type 2 fibers and the diagnosis of an accompanying lipid storage myopathy was made. This case also had a ventricular septal defect confirmed by right cardiac catheterization. PMID:213538

  6. Water Experiments Related To The "Von Karman Sodium" Dynamo Project

    NASA Astrophysics Data System (ADS)

    Marie, L.; Bourgoin, M.; Petrelis, F.; Roy, J.; Burguete, J.; Chiffaudel, A.; Daviaud, F.; Fauve, S.; Odier, P.; Pinton, J.-F.

    2002-07-01

    The purpose of the "Von Karman Sodium" (V.K.S.) experiment is to study the "Dynamo Effect," namely the spontaneous generation of magnetic field in a flow of electrically conducting fluid. The device has been built at CEA / Cadarache, in collaboration with CEA / Saclay, Ecole Normale Superieure de Lyon and Ecole Normale Superieure de Paris. It consists of a cylindrical vessel, filled with liquid Sodium, in which two coaxial rotating disks induce a Von-Karman type flow. Several experimental runs have taken place since June 2000. In order to optimize the V.K.S. set-up, a half-scale water prototype has also been built. It has allowed us to measure mean velocity profiles, as well as pressure fluctuations and mechanical power dissipation. We have observed that under certain circumstances the mean component of the turbulent flow can undergo a global bifurcation.

  7. Von eingebetteten Systemen zu Cyber-Physical Systems

    NASA Astrophysics Data System (ADS)

    Wedde, Rorst F.; Lehnhoff, Sebastian; Rehtanz, Christian; Krause, Olav

    Das Hauptanliegen des Papiers ist, ein Paradigma für Probleme mit neuartigen Integrationsanforderungen für Forschung und Entwicklung in verteilten eingebetteten Echtzeitsystemen zu motivieren und vorzustellen, nämlich den Begriff Cyber-Physical Systems. Bei einer in letzter Zeit stark zunehmenden Anzahl von Realzeitanwendungen können ohne die Berücksichtigung solcher Forderungen keine praktisch brauchbaren Lösungen erwartet werden. Einige Anwendungsfelder werden angesprochen. Im Einzelnen werden dann für Elektroautos, die mit erneuerbaren Energien betrieben werden sollen, einerseits die Management-, verteilte Verhandlungs- und Verteilungsprobleme der benötigten Energie in einem bottom-up Ansatz gelöst. Andererseits wird als Teil unserer Projektarbeit die Bereitstellung von Reserveenergie für den allgemeinen Bedarf durch Autobatterien vorgestellt. Es zeigt sich, dass dies effizienter und wesentlich kurzfristiger in unserem verteilten Vorgehen geschehen kann als in traditionellen Verfahren.

  8. Dr. von Braun In Front of a Display of Missiles

    NASA Technical Reports Server (NTRS)

    1960-01-01

    In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

  9. Dr. Wernher Von Braun at the launch of Apollo 11.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Mission officials relax, all smiles, a few moments after the successful launch of the Apollo 11 spacecraft by Saturn V vehicle AS-506. Relieved of the tension of waiting through the countdown are (left to right) Charles W. Matthews, NASA deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Director of the Marshall Space Flight Center; Dr. George E. Meuller, NASA associate administrator for manned spaceflight, and Lt. General Samuel C. Phillips, director of the Apollo program.

  10. Von Gierke's disease adopts an orphan (and its partner).

    PubMed

    Cheng, Alan; Saltiel, Alan R

    2009-01-01

    The enzyme glucose-6-phosphatase is critical for maintaining fasting blood sugar levels by increasing hepatic glucose production. Its absence in patients with von Gierke's disease leads to severe hypoglycemia and abnormal accumulation of glycogen (glycogenosis) in the liver. New players that control the expression of glucose-6-phosphatase have been identified that may provide insight into this metabolic disorder, as well as type 2 diabetes. PMID:19224896

  11. Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

    NASA Astrophysics Data System (ADS)

    Schneider, Ivo

    The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

  12. Interpolatability distinguishes LOCC from separable von Neumann measurements

    SciTech Connect

    Childs, Andrew M.; Leung, Debbie; Mančinska, Laura; Ozols, Maris

    2013-11-15

    Local operations with classical communication (LOCC) and separable operations are two classes of quantum operations that play key roles in the study of quantum entanglement. Separable operations are strictly more powerful than LOCC, but no simple explanation of this phenomenon is known. We show that, in the case of von Neumann measurements, the ability to interpolate measurements is an operational principle that sets apart LOCC and separable operations.

  13. Canary Island Group and von Karman Cloud Vortices.

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Tis image shows a part of the Canary Island Group (28.0N, 16.0W) located just west of the NW coast of Africa. Low level stratus clouds often form here and become trapped in vertical movement because of an overlaying temperature inversion. The islands create a disturbance in the wind flow, generally from the north or northeast, that create distinctive cloud swirls known as von Karman Cloud Vortices on the downstream side of the island.

  14. von Braun and Buckbee View Demonstration at Space Science Center

    NASA Technical Reports Server (NTRS)

    1960-01-01

    Edward O. Buckbee, the first Director of the Alabama Space Science Center (left), and Dr. Wernher von Braun (right) view a demonstration of a simulated spacecraft which uses an actual hybrid rocket engine for liftoff, hover, and landing. The display was presented to the Alabama Space Science Center, later renamed the U.S. Space and Rocket Center, by United Technology Center, a division of United Aircraft.

  15. The British Interplanetary Society - Val Cleaver and Wernher von Braun

    NASA Astrophysics Data System (ADS)

    Willhite, I. P.

    This article is concerned with the early relationship between Wernher von Braun and the British Interplanetary Society (BIS). The BIS/Wernher von Braun/Val Cleaver correspondence files located here at the US Space & Rocket Center in Huntsville, Alabama are unparalleled. As one reads the stimulating comments between Cleaver and von Braun, the need to share their thoughts prevails. Following is an excerpt from one letter that whets ones appetite for more. 10 June 1951 Cleaver writes, “I'm so glad you enjoyed my last letter, and look forward to your promised further contribution to our discussion of the ethics of science in general and astronautics in particu- lar. As regards the one particular point on which you found yourself unable to hold your fire, I should say there are really two distinct issues at stake:. . .” This article attempts to represent the best of the letters as they goad each other on scientific principles, means to prevent wars, and other philosophic ideas.

  16. Public information needs after the poisoning of Alexander Litvinenko with polonium-210 in London: cross sectional telephone survey and qualitative analysis

    PubMed Central

    Page, Lisa; Morgan, Oliver; Pinder, Richard J; Riley, Paul; Hatch, Stephani; Maguire, Helen; Catchpole, Mike; Simpson, John; Wessely, Simon

    2007-01-01

    Objectives To identify public perceptions of the risk to health after the poisoning of Alexander Litvinenko with polonium-210 (210Po) in London and to assess the impact of public health communications. Design Cross sectional telephone survey and qualitative interviews. Setting London, United Kingdom. Participants 1000 people completed the cross sectional survey and 86 potentially exposed people completed the qualitative interviews. Main outcome measures Perception of risk to personal health after the 210Po incident. Qualitative interviews were analysed with an emphasis on information needs. Results 11.7% of the survey sample (n=117) perceived their health to be at risk. Aside from personal variables the main predictors of perceived risk to health were believing that the incident was related to terrorism (odds ratio 2.7, 95% confidence interval 1.5 to 4.6) rather than to espionage, that it was targeted at the wider public rather than one person (5.9, 3.2 to 10.9), and that it could affect people who had not been in the contaminated area (3.2, 2.1 to 5.1). Participants in the qualitative interviews were generally satisfied with the information they had received, although they would have preferred more information about their individual risk of exposure, the results of their urine tests, and the health implications of the incident. Conclusions Perceptions of the public that the 210Po incident in London in 2006 was related to espionage helped to reassure them that the risks to personal health were low. In the event of future incidents it is important to ensure that detailed, comprehensible information about the risks of any exposure is available. PMID:17975252

  17. 78 FR 61948 - Culturally Significant Objects Imported for Exhibition Determinations: “Franz von Stuck”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-07

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Franz von Stuck'' SUMMARY: Notice is..., I hereby determine that the objects to be included in the exhibition ``Franz von Stuck,'' imported... objects are imported pursuant to loan agreements with the foreign owners or custodians. I also...

  18. 76 FR 36166 - Culturally Significant Objects Imported for Exhibition; Determinations: “Gabriel von Max: Be...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition; Determinations: ``Gabriel von Max: Be-Tailed Cousins... the exhibition ``Gabriel von Max: Be-Tailed Cousins and Phantasms of the Soul,'' imported from...

  19. The Fate of Western Civilization: G. H. von Wright's Reflections on Science, Technology, and Global Society

    ERIC Educational Resources Information Center

    Heikkero, Topi

    2004-01-01

    This article introduces the central ideas of G. H. von Wright's cultural philosophy concerning the techno-scientific form of life. Georg Henrik von Wright (1916-2003) was best known for his achievements in the field of modal logic and for his association with Ludwig Wittgenstein. However, his work also included a critical analysis of science and…

  20. Spin torque oscillator neuroanalog of von Neumann's microwave computer.

    PubMed

    Hoppensteadt, Frank

    2015-10-01

    Frequency and phase of neural activity play important roles in the behaving brain. The emerging understanding of these roles has been informed by the design of analog devices that have been important to neuroscience, among them the neuroanalog computer developed by O. Schmitt and A. Hodgkin in the 1930s. Later J. von Neumann, in a search for high performance computing using microwaves, invented a logic machine based on crystal diodes that can perform logic functions including binary arithmetic. Described here is an embodiment of his machine using nano-magnetics. Electrical currents through point contacts on a ferromagnetic thin film can create oscillations in the magnetization of the film. Under natural conditions these properties of a ferromagnetic thin film may be described by a nonlinear Schrödinger equation for the film's magnetization. Radiating solutions of this system are referred to as spin waves, and communication within the film may be by spin waves or by directed graphs of electrical connections. It is shown here how to formulate a STO logic machine, and by computer simulation how this machine can perform several computations simultaneously using multiplexing of inputs, that this system can evaluate iterated logic functions, and that spin waves may communicate frequency, phase and binary information. Neural tissue and the Schmitt-Hodgkin, von Neumann and STO devices share a common bifurcation structure, although these systems operate on vastly different space and time scales; namely, all may exhibit Andronov-Hopf bifurcations. This suggests that neural circuits may be capable of the computational functionality as described by von Neumann.

  1. Orthopaedic surgery in patients with von Willebrand disease.

    PubMed

    Siboni, S M; Biguzzi, E; Solimeno, L P; Pasta, G; Mistretta, C; Mannucci, P M; Peyvandi, F

    2014-01-01

    Patients with von Willebrand disease (VWD) may need orthopaedic surgery because of disabling chronic arthropathy due to recurrent joint bleeding. They may also require this surgery independently of their haemostasis disorder. Knowledge regarding the management of orthopaedic surgery in VWD is limited. Description of management of orthopaedic surgery in patients with VWD, based upon retrospective data collection and analysis of 32 orthopaedic procedures carried out over a period of 33 years in 23 patients was the aim of this study. Of 32 procedures, six were minor (three hand surgery, one foot surgery, two others) and 26 were major (seven joint replacements, nine arthroscopic procedures, two foot surgery, eight others). Twenty-two procedures were performed using replacement therapy with plasma-derived concentrates containing both factor VIII (FVIII) and von Willebrand factor (VWF). Two procedures in patients with acquired von Willebrand syndrome (AWVS) were performed using FVIII-VWF concentrates associated with intravenous immunoglobulins, or desmopressin plus tranexamic acid. Seven procedures were performed using desmopressin alone and one using intravenous immunoglobulins in AVWS. Bleeding complications occurred in seven procedures (22%). In one patient, an anti-VWF antibody was diagnosed after surgery. Anticoagulant prophylaxis of venous thromboembolism was implemented in four cases only and in two instances there was excessive bleeding. In conclusion, control of surgical haemostasis was achieved in most patients with VWD undergoing orthopaedic surgery. The control of haemostasis combined with an adequate surgical technique and early post-operative rehabilitation are warranted for the successful performance of orthopaedic surgery in VWD, which requires the involvement of specialized haemophilia centres.

  2. Von Willebrand factor regulates complement on endothelial cells.

    PubMed

    Noone, Damien G; Riedl, Magdalena; Pluthero, Fred G; Bowman, Mackenzie L; Liszewski, M Kathryn; Lu, Lily; Quan, Yi; Balgobin, Steve; Schneppenheim, Reinhard; Schneppenheim, Sonja; Budde, Ulrich; James, Paula; Atkinson, John P; Palaniyar, Nades; Kahr, Walter H A; Licht, Christoph

    2016-07-01

    Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thrombotic thrombocytopenic purpura. However, recent studies suggest that both entities are related as defects in the disease-causing pathways overlap or show functional interactions. Here we investigate the possible functional link of VWF-multimers and the complement system on endothelial cells. Blood outgrowth endothelial cells (BOECs) were obtained from 3 healthy individuals and 2 patients with Type 3 von Willebrand disease lacking VWF. Cells were exposed to a standardized complement challenge via the combination of classical and alternative pathway activation and 50% normal human serum resulting in complement fixation to the endothelial surface. Under these conditions we found the expected release of VWF-multimers causing platelet adhesion onto BOECs from healthy individuals. Importantly, in BOECs derived from patients with von Willebrand disease complement C3c deposition and cytotoxicity were more pronounced than on BOECs derived from normal individuals. This is of particular importance as primary glomerular endothelial cells display a heterogeneous expression pattern of VWF with overall reduced VWF abundance. Thus, our results support a mechanistic link between VWF-multimers and the complement system. However, our findings also identify VWF as a new complement regulator on vascular endothelial cells and suggest that VWF has a protective effect on endothelial cells and complement-mediated injury. PMID:27236750

  3. Spin torque oscillator neuroanalog of von Neumann's microwave computer.

    PubMed

    Hoppensteadt, Frank

    2015-10-01

    Frequency and phase of neural activity play important roles in the behaving brain. The emerging understanding of these roles has been informed by the design of analog devices that have been important to neuroscience, among them the neuroanalog computer developed by O. Schmitt and A. Hodgkin in the 1930s. Later J. von Neumann, in a search for high performance computing using microwaves, invented a logic machine based on crystal diodes that can perform logic functions including binary arithmetic. Described here is an embodiment of his machine using nano-magnetics. Electrical currents through point contacts on a ferromagnetic thin film can create oscillations in the magnetization of the film. Under natural conditions these properties of a ferromagnetic thin film may be described by a nonlinear Schrödinger equation for the film's magnetization. Radiating solutions of this system are referred to as spin waves, and communication within the film may be by spin waves or by directed graphs of electrical connections. It is shown here how to formulate a STO logic machine, and by computer simulation how this machine can perform several computations simultaneously using multiplexing of inputs, that this system can evaluate iterated logic functions, and that spin waves may communicate frequency, phase and binary information. Neural tissue and the Schmitt-Hodgkin, von Neumann and STO devices share a common bifurcation structure, although these systems operate on vastly different space and time scales; namely, all may exhibit Andronov-Hopf bifurcations. This suggests that neural circuits may be capable of the computational functionality as described by von Neumann. PMID:26135205

  4. Observatoriya imeni russkogo astronoma v dalekoj Brazilii. K 100-letiyu so diya rozhdeniya Aleksandra Ivanovicha Postoeva (1900 - 1976) %t An observatory in distant Brazil named after a Russian astronomer (dedicated to Alexander Postoyev (1900 - 1976) centennial anniversary

    NASA Astrophysics Data System (ADS)

    Marques Dos Santos, P.; Matsuura, O. T.

    This is a biographical note on the life of Dr. Alexander Postoyev, a victim of Stalin's purge of Soviet astronomers in 1936 - 1937. Together with his family, he left the Soviet Union in 1943 and lived in Germany as a refugee and a "displaced person" until 1952, when he moved to Brazil. There, he started the second part of his professional career. Thanks to his efforts, the Astronomical and Geophysical Institute (IAG) of the University of Sao Paulo (USP) was for the first time included in programs of international cooperation, thus contributing to the institutional consolidation of IAG/USP as a leading center of astronomical research and teaching in Brazil now.

  5. Kernschmelze Der nachhaltige Einfluss von Nuklearwaffen auf Politik und Wirtschaft

    NASA Astrophysics Data System (ADS)

    Greiner, Bernd

    "Was sollen wir von einer Kultur halten, der die Ethik stets als wesentliches Element des menschlichen Lebens galt, die aber - außer in fachlicher oder spieltheoretischer Terminologie - nicht in der Lage war, über die Möglichkeit zu sprechen, nahezu alle Menschen zu töten?" Der Fragesteller gehört zu den berühmtesten Physikern des 20. Jahrhunderts und zu den nach wie vor Umstrittensten. über ihn wurde in den 1960er Jahren ein international viel beachtetes Theaterstück geschrieben, vor wenigen Jahren gar eine Oper.

  6. Karl Ernst von Baer (1792-1876) and evolution.

    PubMed

    Brauckmann, Sabine

    2012-01-01

    The research program of Karl Ernst von Baer (1792-1876) intended to enhance the comparative approach of animal classification by demonstrating vertebrate affinities (homology). Baer visualized his ideas on development and evolution with an unpublished figure of a branching tree. To buttress his reflections on how species-specific embryogenesis produces a branching tree, he worked out a cladogram-like chart, depicting the ontogeny and phylogeny of vertebrate embryos. For Baer, changes in development were responsible for changes in phenotype. I will offer a new interpretation of Baer's ideas about evolution showing that he believed in the transformation of species and announced such views publicly. PMID:23319342

  7. [Heinrich von Kleist and the true nature of man].

    PubMed

    Larsen, O

    1998-12-10

    In short-stories, novels and plays, the artist's interpretation of human nature may render the reader valuable insights into the basics of human behaviour. This article is a discussion of a short-story about a fictitious earthquake in Chile, written in 1807 by Heinrich von Kleist (1777-1811). The writer shows how feelings of warmth, friendliness and solidarity come out when a catastrophe reduces the relative importance of man-made rules and regulations. But more sombre sides of human nature also come to the surface in the wake of the disaster, and the writer indicates that even the apparently virtuous Christian morality contains severe traits of cruelty and repressiveness.

  8. Karl Ernst von Baer (1792-1876) and evolution.

    PubMed

    Brauckmann, Sabine

    2012-01-01

    The research program of Karl Ernst von Baer (1792-1876) intended to enhance the comparative approach of animal classification by demonstrating vertebrate affinities (homology). Baer visualized his ideas on development and evolution with an unpublished figure of a branching tree. To buttress his reflections on how species-specific embryogenesis produces a branching tree, he worked out a cladogram-like chart, depicting the ontogeny and phylogeny of vertebrate embryos. For Baer, changes in development were responsible for changes in phenotype. I will offer a new interpretation of Baer's ideas about evolution showing that he believed in the transformation of species and announced such views publicly.

  9. Karl ernst von Baer's 'Uber Entwickelungsgeschichte der Thiere II' and its unpublished drawings.

    PubMed

    Tammiksaar, Erki; Brauckmann, Sabine

    2004-01-01

    In 1828 Karl Ernst von Baer (1792-1876) published his seminal Uber Entwickelungsgeschichte der Thiere. Beobachtung und Reflexion. In the preface he announced that a second volume with one copper plate would be finished 'in a few weeks'. However, it took nine years until the unfinished second volume was released, with four copperplates. In his 'Autobiography', von Baer did not clarify the reasons why he did not finish his research program of comparative embryology. The paper attempts to elucidate them, furnished by archival documents and von Baer's unpublished embryological drawings. Our sketch of a few figures will show that (1) von Baer searched for 'analogies' (homologies) as a unifying principle and (2) explained the mechanisms of embryogenesis by physiological reasoning (electromagnetism). The main objective is to show that technical problems in illustrating and conceptual difficulties impeded von Baer's ambitious research program. PMID:16302690

  10. von Baer's law for the ages: lost and found principles of developmental evolution.

    PubMed

    Abzhanov, Arhat

    2013-12-01

    In 1828, Karl Ernst von Baer formulated a series of empirically defined rules, which became widely known as the 'Law of Development' or 'von Baer's law of embryology'. This was one the most significant attempts to define the principles that connected morphological complexity and embryonic development. Understanding this relation is central to both evolutionary biology and developmental genetics. Von Baer's ideas have been both a source of inspiration to generations of biologists and a target of continuous criticism over many years. With advances in multiple fields, including paleontology, cladistics, phylogenetics, genomics, and cell and developmental biology, it is now possible to examine carefully the significance of von Baer's law and its predictions. In this review, I argue that, 185 years after von Baer's law was first formulated, its main concepts after proper refurbishing remain surprisingly relevant in revealing the fundamentals of the evolution-development connection, and suggest that their explanation should become the focus of renewed research. PMID:24120296

  11. Karl ernst von Baer's 'Uber Entwickelungsgeschichte der Thiere II' and its unpublished drawings.

    PubMed

    Tammiksaar, Erki; Brauckmann, Sabine

    2004-01-01

    In 1828 Karl Ernst von Baer (1792-1876) published his seminal Uber Entwickelungsgeschichte der Thiere. Beobachtung und Reflexion. In the preface he announced that a second volume with one copper plate would be finished 'in a few weeks'. However, it took nine years until the unfinished second volume was released, with four copperplates. In his 'Autobiography', von Baer did not clarify the reasons why he did not finish his research program of comparative embryology. The paper attempts to elucidate them, furnished by archival documents and von Baer's unpublished embryological drawings. Our sketch of a few figures will show that (1) von Baer searched for 'analogies' (homologies) as a unifying principle and (2) explained the mechanisms of embryogenesis by physiological reasoning (electromagnetism). The main objective is to show that technical problems in illustrating and conceptual difficulties impeded von Baer's ambitious research program.

  12. von Baer's law for the ages: lost and found principles of developmental evolution.

    PubMed

    Abzhanov, Arhat

    2013-12-01

    In 1828, Karl Ernst von Baer formulated a series of empirically defined rules, which became widely known as the 'Law of Development' or 'von Baer's law of embryology'. This was one the most significant attempts to define the principles that connected morphological complexity and embryonic development. Understanding this relation is central to both evolutionary biology and developmental genetics. Von Baer's ideas have been both a source of inspiration to generations of biologists and a target of continuous criticism over many years. With advances in multiple fields, including paleontology, cladistics, phylogenetics, genomics, and cell and developmental biology, it is now possible to examine carefully the significance of von Baer's law and its predictions. In this review, I argue that, 185 years after von Baer's law was first formulated, its main concepts after proper refurbishing remain surprisingly relevant in revealing the fundamentals of the evolution-development connection, and suggest that their explanation should become the focus of renewed research.

  13. Klassifikation von Standardebenen in der 2D-Echokardiographie mittels 2D-3D-Bildregistrierung

    NASA Astrophysics Data System (ADS)

    Bergmeir, Christoph; Subramanian, Navneeth

    Zum Zweck der Entwicklung eines Systems, das einen unerfahrenen Anwender von Ultraschall (US) zur Aufnahme relevanter anatomischer Strukturen leitet, untersuchen wir die Machbarkeit von 2D-US zu 3D-CT Registrierung. Wir verwenden US-Aufnahmen von Standardebenen des Herzens, welche zu einem 3D-CT-Modell registriert werden. Unser Algorithmus unterzieht sowohl die US-Bilder als auch den CT-Datensatz Vorverarbeitungsschritten, welche die Daten durch Segmentierung auf wesentliche Informationen in Form von Labein für Muskel und Blut reduzieren. Anschließend werden diese Label zur Registrierung mittels der Match-Cardinality-Metrik genutzt. Durch mehrmaliges Registrieren mit verschiedenen Initialisierungen ermitteln wir die im US-Bild sichtbare Standardebene. Wir evaluierten die Methode auf sieben US-Bildern von Standardebenen. Fünf davon wurden korrekt zugeordnet.

  14. Evaluating return on investment in a school based health promotion and prevention program: the investment multiplier for the Stephanie Alexander Kitchen Garden National Program.

    PubMed

    Eckermann, Simon; Dawber, James; Yeatman, Heather; Quinsey, Karen; Morris, Darcy

    2014-08-01

    Successful health promotion and disease prevention strategies in complex community settings such as primary schools rely on acceptance and ownership across community networks. Assessing multiplier impacts from investment on related community activity over time are suggested as key alongside evidence of program health effects on targeted groups of individuals in gauging community network engagement and ownership, dynamic impacts, and program long term success and return on investment. An Australian primary school based health promotion and prevention strategy, the Stephanie Alexander Kitchen Garden National Program (SAKGNP), which has been providing garden and kitchen classes for year 3-6 students since 2008, was evaluated between 2011 and 2012. Returns on Australian Federal Government investment for school infrastructure grants up to $60,000 are assessed up to and beyond a two year mutual obligation period with: (i) Impacts on student lifestyle behaviours, food choices and eating habits surveyed across students (n = 491 versus 260) and parents (n = 300 versus 234) in 28 SAKGNP and 14 matched schools, controlling for school and parent level confounders and triangulated with SAKGNP pre-post analysis; (ii) Multiplier impacts of investment on related school and wider community activity up to two years; and (iii) Evidence of continuation and program evolution in schools observed beyond two years. SAKGNP schools showed improved student food choices (p = 0.024) and kitchen lifestyle behaviour (p = 0.019) domains compared to controls and in pre-post analysis where 20.0% (58/290) reported eating fruit and vegetables more often and 18.6% (54/290) preparing food at home more often. No significant differences were found in case control analysis for eating habits or garden lifestyle behaviour domains, although 32.3% of children helped more in the garden (91/278) and 15.6% (45/289) ate meals together more often in pre-post analysis. The multiplier impact on total

  15. Evaluating return on investment in a school based health promotion and prevention program: the investment multiplier for the Stephanie Alexander Kitchen Garden National Program.

    PubMed

    Eckermann, Simon; Dawber, James; Yeatman, Heather; Quinsey, Karen; Morris, Darcy

    2014-08-01

    Successful health promotion and disease prevention strategies in complex community settings such as primary schools rely on acceptance and ownership across community networks. Assessing multiplier impacts from investment on related community activity over time are suggested as key alongside evidence of program health effects on targeted groups of individuals in gauging community network engagement and ownership, dynamic impacts, and program long term success and return on investment. An Australian primary school based health promotion and prevention strategy, the Stephanie Alexander Kitchen Garden National Program (SAKGNP), which has been providing garden and kitchen classes for year 3-6 students since 2008, was evaluated between 2011 and 2012. Returns on Australian Federal Government investment for school infrastructure grants up to $60,000 are assessed up to and beyond a two year mutual obligation period with: (i) Impacts on student lifestyle behaviours, food choices and eating habits surveyed across students (n = 491 versus 260) and parents (n = 300 versus 234) in 28 SAKGNP and 14 matched schools, controlling for school and parent level confounders and triangulated with SAKGNP pre-post analysis; (ii) Multiplier impacts of investment on related school and wider community activity up to two years; and (iii) Evidence of continuation and program evolution in schools observed beyond two years. SAKGNP schools showed improved student food choices (p = 0.024) and kitchen lifestyle behaviour (p = 0.019) domains compared to controls and in pre-post analysis where 20.0% (58/290) reported eating fruit and vegetables more often and 18.6% (54/290) preparing food at home more often. No significant differences were found in case control analysis for eating habits or garden lifestyle behaviour domains, although 32.3% of children helped more in the garden (91/278) and 15.6% (45/289) ate meals together more often in pre-post analysis. The multiplier impact on total

  16. Comparison between von Willebrand factor (VWF) and VWF antigen II in normal individuals and patients with von Willebrand disease.

    PubMed

    de Romeuf, C; Mazurier, C

    1998-07-01

    Von Willebrand disease is characterised by a quantitative (type 1) or qualitative (type 2) decrease in von Willebrand factor (vWF) a multimeric glycoprotein involved in primary haemostasis. The propeptide of von Willebrand, also named vWF antigen II (vWF:AgII), is released from platelets and endothelial cells and circulates in plasma as a glycoprotein of 100 kD. In the present study, we attempted to determine whether vWF:AgII level may provide information on the synthesis of vWF, specially in patients with von Willebrand disease (vWD). To elucidate that point, we developed an ELISA and quantify the vWF:AgII in normal individuals and in various vWD patients. The propeptide molar concentration was found to be 5 nM as compared to 31 nM for mature vWF. In normal individuals, the level of vWF:AgII was significantly decreased in females from O and A blood groups. In type 2 vWD patients the level of plasma vWF:AgII appears normal in the patients with normal level of platelet vWF. In type 2 B vWD characterised by increased affinity of mature vWF for platelet glycoprotein Ib, the vWF:AgII in contrast to the vWF antigen (vWF:Ag) was not decreased. In type 2A vWD patients the level of vWF:AgII was decreased in patients with absence of high molecular weight vWF in platelets and plasma but normal in patients with increased sensitivity to proteolysis. Finally, in type 1 vWD, some studied patients have a parallel decrease in vWF:AgII and vWF:Ag whereas in others, the vWF:Ag levels were much more affected than corresponding vWF:AgII levels, as observed in some type 2 vWD patients. Thus, in contrast to that already described, the plasma vWF:AgII level cannot discriminate type 1 from type 2 vWD patients. We conclude that the vWF:AgII measurement provides additional information on the mechanisms responsible for vWD and might also contribute to the classification of vWD patients. PMID:9684782

  17. Von Braun Rocket Team at Fort Bliss, Texas

    NASA Technical Reports Server (NTRS)

    1940-01-01

    The German Rocket Team, also known as the Von Braun Rocket Team, poses for a group photograph at Fort Bliss, Texas. After World War II ended in 1945, Dr. Wernher von Braun led some 120 of his Peenemuende Colleagues, who developed the V-2 rocket for the German military during the War, to the United Sttes under a contract to the U.S. Army Corps as part of Operation Paperclip. During the following five years the team worked on high altitude firings of the captured V-2 rockets at the White Sands Missile Range in New Mexico, and a guided missile development unit at Fort Bliss, Texas. In April 1950, the group was transferred to the Army Ballistic Missile Agency (ABMA) at Redstone Arsenal in Huntsville, Alabama, and continued to work on the development of the guided missiles for the U.S. Army until transferring to a newly established field center of the National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC).

  18. Acquired von Willebrand syndrome associated with left ventricular assist device.

    PubMed

    Nascimbene, Angelo; Neelamegham, Sriram; Frazier, O H; Moake, Joel L; Dong, Jing-Fei

    2016-06-23

    Left ventricular assist devices (LVAD) provide cardiac support for patients with end-stage heart disease as either bridge or destination therapy, and have significantly improved the survival of these patients. Whereas earlier models were designed to mimic the human heart by producing a pulsatile flow in parallel with the patient's heart, newer devices, which are smaller and more durable, provide continuous blood flow along an axial path using an internal rotor in the blood. However, device-related hemostatic complications remain common and have negatively affected patients' recovery and quality of life. In most patients, the von Willebrand factor (VWF) rapidly loses large multimers and binds poorly to platelets and subendothelial collagen upon LVAD implantation, leading to the term acquired von Willebrand syndrome (AVWS). These changes in VWF structure and adhesive activity recover quickly upon LVAD explantation and are not observed in patients with heart transplant. The VWF defects are believed to be caused by excessive cleavage of large VWF multimers by the metalloprotease ADAMTS-13 in an LVAD-driven circulation. However, evidence that this mechanism could be the primary cause for the loss of large VWF multimers and LVAD-associated bleeding remains circumstantial. This review discusses changes in VWF reactivity found in patients on LVAD support. It specifically focuses on impacts of LVAD-related mechanical stress on VWF structural stability and adhesive reactivity in exploring multiple causes of AVWS and LVAD-associated hemostatic complications. PMID:27143258

  19. A visit paid to Jung by Alwine von Keller.

    PubMed

    Bernardini, Riccardo; Quaglino, Gian Piero; Romano, Augusto

    2011-04-01

    In the winter of 1943-1944, Jung had suffered a coronary thrombosis which almost cost him his life. During his illness, Jung experienced a series of visions, described in his Memories, Dreams, Reflections, which were also to influence significantly the development of his theoretical thinking. On 27(th) September 1944, Alwine von Keller (1878-1965) paid a visit to Jung, while he was still convalescing, in Zurich and documented her meeting with him in a series of notes, recently discovered, which testify to the fact that, at the time of their meeting, Jung was engaged in writing the 'Salt' chapter of Mysterium coniunctionis and investigating the alchemistic symbolism of the 'sea'. This theme seems to testify to a continuity of interests on Jung's part with the seminar he held at Eranos the previous year on the cartographic art of Opicinus de Canistris (1296-c.1352). With its addition of many unpublished details, Alwine von Keller's notes supplement the report which Jung made of his visions experienced during his sickness in MDR. In particular, these attest to the fact that Jung had attributed the terrible experience which he had endured to the problem of the conjunctio, which was confronting him from the theoretical point of view in his writing of Mysterium coniunctionis.

  20. Attractors and Long Time Behavior of von Karman Thermoelastic Plates

    SciTech Connect

    Chueshov, Igor Lasiecka, Irena

    2008-10-15

    This paper undertakes a study of asymptotic behavior of solutions corresponding to von Karman thermoelastic plates. A distinct feature of the work is that the model considered has no added dissipation-particularly mechanical dissipation typically added to plate equation when long time-behavior is considered. Thus, the model consists of undamped oscillatory plate equation strongly coupled with heat equation. Nevertheless we are able to show that the ultimate (asymptotic) behavior of the von Karman evolution is described by finite dimensional global attractor. In addition, the obtained estimate for the dimension and the size of the attractor are independent of the rotational inertia parameter {gamma} and heat/thermal capacity {kappa}, where the former is known to change the character of dynamics from hyperbolic ({gamma}>0) to parabolic like ({gamma}=0). Other properties of attractors such as additional smoothness and upper-semicontinuity with respect to parameters {gamma} and {kappa} are also established. The main ingredients of the proofs are (i) sharp regularity of Airy's stress function, and (ii) newly developed (Chueshov and Lasiecka in Memoirs of AMS, in press) 'compensated' compactness methods applicable to non-compact dynamics.

  1. The von Neumann model of measurement in quantum mechanics

    SciTech Connect

    Mello, Pier A.

    2014-01-08

    We describe how to obtain information on a quantum-mechanical system by coupling it to a probe and detecting some property of the latter, using a model introduced by von Neumann, which describes the interaction of the system proper with the probe in a dynamical way. We first discuss single measurements, where the system proper is coupled to one probe with arbitrary coupling strength. The goal is to obtain information on the system detecting the probe position. We find the reduced density operator of the system, and show how Lüders rule emerges as the limiting case of strong coupling. The von Neumann model is then generalized to two probes that interact successively with the system proper. Now we find information on the system by detecting the position-position and momentum-position correlations of the two probes. The so-called 'Wigner's formula' emerges in the strong-coupling limit, while 'Kirkwood's quasi-probability distribution' is found as the weak-coupling limit of the above formalism. We show that successive measurements can be used to develop a state-reconstruction scheme. Finally, we find a generalized transform of the state and the observables based on the notion of successive measurements.

  2. Superfluid high REynolds von Kármán experiment.

    PubMed

    Rousset, B; Bonnay, P; Diribarne, P; Girard, A; Poncet, J M; Herbert, E; Salort, J; Baudet, C; Castaing, B; Chevillard, L; Daviaud, F; Dubrulle, B; Gagne, Y; Gibert, M; Hébral, B; Lehner, Th; Roche, P-E; Saint-Michel, B; Bon Mardion, M

    2014-10-01

    The Superfluid High REynolds von Kármán experiment facility exploits the capacities of a high cooling power refrigerator (400 W at 1.8 K) for a large dimension von Kármán flow (inner diameter 0.78 m), which can work with gaseous or subcooled liquid (He-I or He-II) from room temperature down to 1.6 K. The flow is produced between two counter-rotating or co-rotating disks. The large size of the experiment allows exploration of ultra high Reynolds numbers based on Taylor microscale and rms velocity [S. B. Pope, Turbulent Flows (Cambridge University Press, 2000)] (Rλ > 10000) or resolution of the dissipative scale for lower Re. This article presents the design and first performance of this apparatus. Measurements carried out in the first runs of the facility address the global flow behavior: calorimetric measurement of the dissipation, torque and velocity measurements on the two turbines. Moreover first local measurements (micro-Pitot, hot wire,…) have been installed and are presented. PMID:25362417

  3. Renaturierung von Ökosystemen in urban-industriellen Landschaften

    NASA Astrophysics Data System (ADS)

    Rebele, Franz

    Die Urbanisierung ist ein weltweit stattfindender Prozess mit weitreichenden Auswirkungen auf Mensch und Natur. In Mitteleuropa leben heute etwa 80% aller Bewohner in Städten. Urban-industrielle Landschaften gehören deshalb zur unmittelbaren Lebensumwelt der meisten Menschen. Allein in Deutschland wird heute täglich eine Fläche von 120 ha neu für Siedlungs- und Verkehrszwecke in Anspruch genommen. Zu den Siedlungs- und Verkehrsflächen zählen Gebäude-und gebäudebezogene Freiflächen, Verkehrsflächen, Erholungsflächen und Friedhöfe sowie Betriebsflächen für Industrie und Gewerbe. Nicht enthalten sind Tagebauflächen zum Abbau von Bodenschätzen (Kapitel 13). In Deutschland liegt der Anteil der Siedlungs- und Verkehrsflächen an der Gesamtfläche derzeit bei ca. 13%, in Österreich bei 5 % und in der Schweiz bei knapp 7 %. Charakteristisch für die heutige Entwicklung in Mitteleuropa ist, dass die Prozesse der Urbanisierung und der Flächeninanspruchnahme für Siedlung und Verkehr nicht ursächlich mit einem Bevölkerungswachstum verbunden sind, d. h. dass Freiflächen auch bei stagnierender oder in manchen Regionen sogar bei sinkender Einwohnerzahl bebaut werden.

  4. von Willebrand factor, Jedi knight of the bloodstream.

    PubMed

    Springer, Timothy A

    2014-08-28

    When blood vessels are cut, the forces in the bloodstream increase and change character. The dark side of these forces causes hemorrhage and death. However, von Willebrand factor (VWF), with help from our circulatory system and platelets, harnesses the same forces to form a hemostatic plug. Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use "the Force" to do good, VWF may be considered the Jedi knight of the bloodstream. The long length of VWF enables responsiveness to flow. The shape of VWF is predicted to alter from irregularly coiled to extended thread-like in the transition from shear to elongational flow at sites of hemostasis and thrombosis. Elongational force propagated through the length of VWF in its thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and likely also increases affinity of the A1 domain for platelets. Specialized domains concatenate and compact VWF during biosynthesis. A2 domain unfolding by hydrodynamic force enables postsecretion regulation of VWF length. Mutations in VWF in von Willebrand disease contribute to and are illuminated by VWF biology. I attempt to integrate classic studies on the physiology of hemostatic plug formation into modern molecular understanding, and point out what remains to be learned.

  5. Contemporary issues in the management of von Willebrand disease.

    PubMed

    Federici, Augusto B; Königs, Christoph; James, Andra H

    2016-08-31

    Von Willebrand disease (VWD) is the most common inherited bleeding disorder. Bleeding scores in VWD, focused in particular on mucosal bleeding, can be very useful in the diagnosis and validation of different types of treatment. The results of an extended prospective study with a large amount of information on clinical phenotype and implications in treatment are reviewed in this article. Treatment of mucosal and joint bleeding in severe VWD remains difficult in some patients. Due to the lack of data on the use of prophylaxis in these patients it is difficult to establish optimal treatment regimens. An overview of the literature, with a focus on the ongoing PRO.WILL study, is provided here. Furthermore, understanding the changes in von Willebrand factor (VWF) levels during pregnancy is very important for establishing the optimal management strategy for pregnancy and delivery in women with VWD. A recently published prospective observational cohort study in women with and without VWD during the postpartum period provides important data that should allow the improvement of postpartum treatment protocols.

  6. Superfluid high REynolds von Kármán experiment

    NASA Astrophysics Data System (ADS)

    Rousset, B.; Bonnay, P.; Diribarne, P.; Girard, A.; Poncet, J. M.; Herbert, E.; Salort, J.; Baudet, C.; Castaing, B.; Chevillard, L.; Daviaud, F.; Dubrulle, B.; Gagne, Y.; Gibert, M.; Hébral, B.; Lehner, Th.; Roche, P.-E.; Saint-Michel, B.; Bon Mardion, M.

    2014-10-01

    The Superfluid High REynolds von Kármán experiment facility exploits the capacities of a high cooling power refrigerator (400 W at 1.8 K) for a large dimension von Kármán flow (inner diameter 0.78 m), which can work with gaseous or subcooled liquid (He-I or He-II) from room temperature down to 1.6 K. The flow is produced between two counter-rotating or co-rotating disks. The large size of the experiment allows exploration of ultra high Reynolds numbers based on Taylor microscale and rms velocity [S. B. Pope, Turbulent Flows (Cambridge University Press, 2000)] (Rλ > 10000) or resolution of the dissipative scale for lower Re. This article presents the design and first performance of this apparatus. Measurements carried out in the first runs of the facility address the global flow behavior: calorimetric measurement of the dissipation, torque and velocity measurements on the two turbines. Moreover first local measurements (micro-Pitot, hot wire,…) have been installed and are presented.

  7. Obituary: Alexander Dalgarno (1928 - 2015)

    NASA Astrophysics Data System (ADS)

    Hartquist, Tom; Babb, James F. Babb; Loeb, Avi

    Alex Dalgarno's major contributions to the understanding of fundamental atomic and molecular processes enabled him to develop diagnostics of the physical conditions of atmospheres and astrophysical sources and to elucidate the roles of such processes in controlling those environments. He greatly influenced the research of physicists, chemists, atmospheric scientists, and astronomers, leading Sir David Bates to write, "There is no greater figure than Alex in the history of atomic physics and its applications." Alex was born and grew up in London. As a child, he enjoyed mathematical puzzles and did well at sports. He was invited to try out for the Tottenham Hotspur soccer team, but his professional sporting career ended due to an injury, which did not prevent Alex playing tennis and squash into his ninth decade. In 1945 Alex began to study Mathematics at University College London (UCL). In 1947 Sir Harrie Massey invited him to work for a PhD in Physics and suggested that Alex investigate collisions of metastable helium atoms in helium gas to determine the cross sections for excitation transfer. Richard Buckingham was Alex's immediate supervisor. After completing his graduate study in 1951, Alex became a member of staff in Applied Mathematics at the Queen's University of Belfast (QUB). He served as the Director of the Computational Laboratory after a 1954 visit to MIT, which had an electronic computer, led Alex to persuade colleagues that QUB needed one. In 1957, the poet Philip Larkin was the best man at the marriage of Alex to Barbara Kane. They had four children, Fergus, Penelope, Piers, and Rebecca, but the marriage dissolved after ten years. Alex's important work during the 1950s on the quantitative evaluation of long-range interactions underpinned his collaborations on precise scattering calculations relevant to ultra-cold collisions and the formation of atomic Bose-Einstein condensates over four decades later. He investigated the theory of atomic and molecular collisions and calculated charge transfer cross sections. Some of these proved later to be important for forming the spectra of diffuse astronomical matter surrounding high mass stars and 100 million solar mass black holes at the centers of active galaxies. In the early 1950s David Bates stimulated Alex's interest in the study of quantum processes occurring in the upper terrestrial atmosphere. Together they considered the sources of the nightglow and dayglow features and concluded that the altitudes previously inferred for them from observations were up to several hundred kilometers too large. Experiments carried on V2 rockets, like those seen by Alex in wartime London, proved him and David to be right. Alex felt that though many theorists believe that "physics is embodied in its equations," it is instead "to be found in the solutions to the equations." He was a master at developing and applying methods that simplified calculations leading to reliable solutions. Exploiting the contemporary advances in electronic computation, by the 1960s Alex and his colleagues were able to address atomic and molecular processes of increasing complexity. Their development and early applications of the S-matrix theory of molecular rotational excitation by particle impact triggered major advances in molecular physics and theoretical chemistry and in the understanding of processes important in many environments, including a wide variety of astrophysical sources. In 1967 Alex became a professor in the Harvard Department of Astronomy and a member of the staff of the Smithsonian Astrophysical Observatory. He was a team member for several Atmosphere Explorer satellite missions, which elucidated the roles of atoms and ions in the upper atmosphere and paved the way for further applications to the other planets. By 1969 Alex was publishing papers on molecular hydrogen (H2) radiative processes, including photodissociation, in which the foundations of molecular astrophysics began to emerge. H2 is the most abundant astrophysical molecule and the main constituen

  8. Obituary: Alexander Dalgarno (1928 - 2015)

    NASA Astrophysics Data System (ADS)

    Hartquist, Tom; Babb, James F. Babb; Loeb, Avi

    Alex Dalgarno's major contributions to the understanding of fundamental atomic and molecular processes enabled him to develop diagnostics of the physical conditions of atmospheres and astrophysical sources and to elucidate the roles of such processes in controlling those environments. He greatly influenced the research of physicists, chemists, atmospheric scientists, and astronomers, leading Sir David Bates to write, "There is no greater figure than Alex in the history of atomic physics and its applications." Alex was born and grew up in London. As a child, he enjoyed mathematical puzzles and did well at sports. He was invited to try out for the Tottenham Hotspur soccer team, but his professional sporting career ended due to an injury, which did not prevent Alex playing tennis and squash into his ninth decade. In 1945 Alex began to study Mathematics at University College London (UCL). In 1947 Sir Harrie Massey invited him to work for a PhD in Physics and suggested that Alex investigate collisions of metastable helium atoms in helium gas to determine the cross sections for excitation transfer. Richard Buckingham was Alex's immediate supervisor. After completing his graduate study in 1951, Alex became a member of staff in Applied Mathematics at the Queen's University of Belfast (QUB). He served as the Director of the Computational Laboratory after a 1954 visit to MIT, which had an electronic computer, led Alex to persuade colleagues that QUB needed one. In 1957, the poet Philip Larkin was the best man at the marriage of Alex to Barbara Kane. They had four children, Fergus, Penelope, Piers, and Rebecca, but the marriage dissolved after ten years. Alex's important work during the 1950s on the quantitative evaluation of long-range interactions underpinned his collaborations on precise scattering calculations relevant to ultra-cold collisions and the formation of atomic Bose-Einstein condensates over four decades later. He investigated the theory of atomic and molecular collisions and calculated charge transfer cross sections. Some of these proved later to be important for forming the spectra of diffuse astronomical matter surrounding high mass stars and 100 million solar mass black holes at the centers of active galaxies. In the early 1950s David Bates stimulated Alex's interest in the study of quantum processes occurring in the upper terrestrial atmosphere. Together they considered the sources of the nightglow and dayglow features and concluded that the altitudes previously inferred for them from observations were up to several hundred kilometers too large. Experiments carried on V2 rockets, like those seen by Alex in wartime London, proved him and David to be right. Alex felt that though many theorists believe that "physics is embodied in its equations," it is instead "to be found in the solutions to the equations." He was a master at developing and applying methods that simplified calculations leading to reliable solutions. Exploiting the contemporary advances in electronic computation, by the 1960s Alex and his colleagues were able to address atomic and molecular processes of increasing complexity. Their development and early applications of the S-matrix theory of molecular rotational excitation by particle impact triggered major advances in molecular physics and theoretical chemistry and in the understanding of processes important in many environments, including a wide variety of astrophysical sources. In 1967 Alex became a professor in the Harvard Department of Astronomy and a member of the staff of the Smithsonian Astrophysical Observatory. He was a team member for several Atmosphere Explorer satellite missions, which elucidated the roles of atoms and ions in the upper atmosphere and paved the way for further applications to the other planets. By 1969 Alex was publishing papers on molecular hydrogen (H2) radiative processes, including photodissociation, in which the foundations of molecular astrophysics began to emerge. H2 is the most abundant astrophysical molecule and the main constituent of the regions where stars form. Interstellar H2 was first detected directly in the following year, and data for interstellar H2 began to become abundant in 1973. Alex was well prepared and led efforts to interpret these data, from which he was able to infer the physical properties of diffuse interstellar molecular clouds. At nearly the same time he was involved in work on the ionization and energy deposition in H2 by nearly relativistic and relativistic particles called cosmic rays. The work has relevance to emission in the atmospheres of the giant planets, as well as for conditions in interstellar molecular clouds. Cosmic ray induced ionization initiates much of the basic chemistry in star forming regions, and the emissions of the product molecules control the temperatures and allow the diagnosis of the physical conditions and dynamics of the stellar nurseries. For more than four decades Alex elucidated the chemical networks governing the molecular abundances in a wide variety of astrophysical sources including star forming regions, supernova ejecta, the pregalactic universe, and extreme environments like those in the vicinities of X-ray sources powered by accretion onto black holes. The refinement of the models led to calculations predicting the existence of subsequently discovered negative ions in giant molecular clouds. One of his astrophysical interests that intrigued him late in his career was the emission of soft X-rays by comets and in the heliosphere due to charge transfer with solar wind particles, and he also worked on related processes occurring in the atmospheres of the giant planets. Alex remained very active in fundamental atomic and molecular physics, as well as for its applications to astrophysics and to terrestrial and extraterrestrial planetary atmospheres. Ultra-cold collisions and ultra-cold chemistry were major interests for Alex for much of the latest phase of his career, most recently with pioneering work on atom-molecule collisions. In the early 1980s Alex had concerns about the future of atomic, molecular, and optical (AMO) physics in the United States, where it was inadequately funded and somewhat out of fashion in many of the physics departments providing most of the physicists who became university faculty. Alex played a key role in efforts to address this issue and led a proposal to the National Science Foundation that resulted in the founding on 1 November 1988 of the Institute of Theoretical Atomic and Molecular Physics (ITAMP) at the Harvard-Smithsonian Center for Astrophysics. Alex served for five years as the first ITAMP director. A number of the former ITAMP students and postdoctoral researchers have become leading AMO physicists, and its visitor program and workshops have led to the identification and stimulation of the leading areas of AMO physics. Alex was a Fellow of the Royal Society, a member of the National Academy of Sciences, and a member (Honorary) of the Royal Irish Academy. He received many medals, including the Benjamin Franklin Medal in Physics, the Royal Society's Hughes Medal, the Royal Astronomical Society's Gold Medal, the American Geophysical Society's Fleming Medal, and the Royal Society of Chemistry's Spiers Medal. He served as the editor of the Astrophysical Journal Letters for nearly thirty years starting in 1973, as the Chair of the Harvard Department of Astronomy from 1971 to 1976, and as the Acting Director of Harvard College Observatory and then the Acting Director of the Harvard-Smithsonian Center for Astrophysics from 1971 to 1973 during a critical period of its existence. Alex was a gifted mentor who spoke and wrote with pride of his former students and postdoctoral researchers. He was able to match projects very well with the abilities of the students. He made availability to students a special priority, and despite his supply of problems would encourage students as they developed their own. Alex was very supportive of junior scientists as they developed their careers, and in addition to writing many letters of recommendation he made many visits to colleagues as they were establishing themselves elsewhere. Furthermore, Alex very graciously hosted a number of his former students when they visited. He combined quiet modesty with a confidence that reassured others, and his humor was dry, interactive, and friendly. Alex passed away peacefully on 9 April 2015 in Cambridge, Massachusetts in the company of Fern Creelan, who was his partner for 30 years.

  9. Mutations in the D1 domain of von Willebrand factor impair their propeptide-dependent multimerization, intracellular trafficking and secretion.

    PubMed

    Yin, Jie; Ma, Zhenni; Su, Jian; Wang, Jiong-Wei; Zhao, Xiaojuan; Ling, Jing; Bai, Xia; Ouyang, Wanyan; Wang, Zhaoyue; Yu, Ziqiang; Ruan, Changgeng

    2015-01-01

    We identified three novel mutations (p.Gly39Arg, p.Lys157Glu, p.Cys379Gly) and one previously known mutation (p.Asp141Asn) in the von Willebrand factor propeptide from three von Willebrand disease patients. All four mutations impaired multimerization of von Willebrand factor, due to reduced oxidoreductase activity of isomeric propeptide. These mutations resulted in the endothelial reticulum retention and impaired basal and stimulated secretions of von Willebrand factor. Our results support that the mutations in the D1 domain lead to defective multimerization, intracellular trafficking, and secretion of von Willebrand factor and result in bleeding of patients. PMID:26088471

  10. [Structure and function of the factor VIII/von Willebrand factor complex].

    PubMed

    Müller, G

    1990-03-01

    In the blood plasma factor VIII is bound to the von Willebrand factor. The primary structure of the two proteins were clarified by gene clonation. Factor VIII descends from a precursor protein with 2,351 amino acids by splitting of 19 amino acid residues and is activated by partial proteolysis. In the blood coagulation factor VIII acts as co-factor for the activation of factor X by factor IX in the presence of phospholipids and Ca++ within the intrinsic coagulation system. The formation of the von Willebrand factor takes place by splitting of 22 and 741 amino acid residues, respectively, from pre-pro-von Willebrand factor via pro-von Willebrand factor. The subunits of the von Willebrand factor consist od 2,050 amino acid residues. In the blood plasma the von Willebrand factor is existing as a mixture of multimeres. Receptors of the von Willebrand factor on the thrombocytic membrane are the glycoproteins GPIb and GPIIb/GPIIIa, by means of which the adhesion of thrombocytes at the subendoethelium of the vascular wall and the aggregation of thrombocytes are mediated. PMID:2159676

  11. von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.

    PubMed

    Sorvillo, Nicoletta; Hartholt, Robin B; Bloem, Esther; Sedek, Magdalena; ten Brinke, Anja; van der Zwaan, Carmen; van Alphen, Floris P; Meijer, Alexander B; Voorberg, Jan

    2016-03-01

    It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived dendritic cells using flow cytometry and confocal microscopy. Surprisingly, von Willebrand factor was not internalized by immature dendritic cells, but remained bound to the cell surface. As von Willebrand factor reduces the uptake of factor VIII, we investigated the repertoire of factor VIII presented peptides when in complex with von Willebrand factor. Interestingly, factor VIII-derived peptides were still abundantly presented on major histocompatibility complex class II molecules, even though a reduction of factor VIII uptake by immature dendritic cells was observed. Inspection of peptide profiles from 5 different donors showed that different core factor VIII peptide sequences were presented upon incubation with factor VIII/von Willebrand factor complex when compared to factor VIII alone. No von Willebrand factor peptides were detected when immature dendritic cells were pulsed with different concentrations of von Willebrand factor, confirming lack of von Willebrand factor endocytosis. Several von Willebrand factor derived peptides were recovered when cells were pulsed with von Willebrand factor/factor VIII complex, suggesting that factor VIII promotes endocytosis of small amounts of von Willebrand factor by immature dendritic cells. Taken together, our results establish that von Willebrand factor is poorly internalized by immature dendritic cells. We also show that von Willebrand factor modulates the internalization and presentation of factor VIII-derived peptides on major histocompatibility complex class II. PMID:26635035

  12. von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII

    PubMed Central

    Sorvillo, Nicoletta; Hartholt, Robin B.; Bloem, Esther; Sedek, Magdalena; Brinke, Anja ten; van der Zwaan, Carmen; van Alphen, Floris P.; Meijer, Alexander B.; Voorberg, Jan

    2016-01-01

    It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived dendritic cells using flow cytometry and confocal microscopy. Surprisingly, von Willebrand factor was not internalized by immature dendritic cells, but remained bound to the cell surface. As von Willebrand factor reduces the uptake of factor VIII, we investigated the repertoire of factor VIII presented peptides when in complex with von Willebrand factor. Interestingly, factor VIII-derived peptides were still abundantly presented on major histocompatibility complex class II molecules, even though a reduction of factor VIII uptake by immature dendritic cells was observed. Inspection of peptide profiles from 5 different donors showed that different core factor VIII peptide sequences were presented upon incubation with factor VIII/von Willebrand factor complex when compared to factor VIII alone. No von Willebrand factor peptides were detected when immature dendritic cells were pulsed with different concentrations of von Willebrand factor, confirming lack of von Willebrand factor endocytosis. Several von Willebrand factor derived peptides were recovered when cells were pulsed with von Willebrand factor/factor VIII complex, suggesting that factor VIII promotes endocytosis of small amounts of von Willebrand factor by immature dendritic cells. Taken together, our results establish that von Willebrand factor is poorly internalized by immature dendritic cells. We also show that von Willebrand factor modulates the internalization and presentation of factor VIII-derived peptides on major histocompatibility complex class II. PMID:26635035

  13. Ein stochastisches Modell zur Beschreibung von Signalen in digitalen Schaltungen basierend auf quadratischer Optimierung

    NASA Astrophysics Data System (ADS)

    Kleeberger, V. B.; Maier, P.; Schlichtmann, U.

    2013-07-01

    Die kontinuierlich fortschreitende Miniaturisierung in integrierten Schaltungen führt zu einem erhöhten Modellierungsbedarf verschiedenster Effekte, wie z.B. Alterung oder Stromverbrauch. Diese hängen von den auftretenden Signalen innerhalb der Schaltung ab, wodurch deren statistische Modellierung ein zentrales Problem darstellt. Dieser Beitrag stellt eine neue Methode zur stochastischen Signalmodellierung basierend auf quadratischer Optimierung vor. Die Methode wird mit Hilfe von realen Daten mit existierenden Ansätzen verglichen. Die Testergebnisse zeigen hierbei im vorgestellten Modell einen Genauigkeitszuwachs von bis zu einem Faktor 10 im Vergleich zu bereits existierenden Modellen.

  14. [Scientific theoretical founding of medicine as a natural science by Hermann von Helmholtz (1821-1894)].

    PubMed

    Neumann, J N

    1994-01-01

    In this study an attempt will be made to discuss the epistemological problems in the theory and practice of modern technical medicine in the writings of Hermann von Helmholz. An inquiry into the relationship between von Helmholtz' thinking and the critical philosophy of Immanuel Kant is followed by the characteristics of von Helmholtz' philosophy of science which he himself called "empirical theory". The question of medicine as a science finally leads to the main problem of medical epistemology, viz., the relationship between theoretical knowledge and practice in medicine. In this context the anthropological dimension is brought into consideration.

  15. [Ernst von der Porten : looking for facts before and after forced emigration].

    PubMed

    Goerig, M; Bruijn, L

    2014-10-01

    The Ernst von der Porten medal has been awarded for many years to exceptional personalities by the Alliance of German Anesthesiologists to honor the outstanding achievements of the physician Ernst von der Porten from Hamburg in the development of anesthesiology as an autonomous discipline Only recent access to hitherto inaccessible documents enabled the reconstruction of his final years. He was persecuted and excluded by the National Socialist (NS) regime due to his Jewish roots and finally forced to emigrate. Records revealed that even in the so-called safe exile, degrading treatment and humiliation continued for Ernst von der Porten and his family. He eventually evaded this situation by committing suicide.

  16. Two different anesthetic managements of a patient with von Gierke's disease.

    PubMed

    Huang, I-Ren; Jean, Wei-Horng; Lu, Cheng-Wei; Wu, Chia-Chan; Lin, Tzu-Yu; Chuang, Yueh-Hsun; Sun, Wei-Zen

    2006-03-01

    Von Gierke's disease, a form of glycogen storage disturbance, is a rare metabolic disorder with important implications for anesthesiologists. It is caused by the lack of the glucose-6-phosphatase, which is necessary for the liver to convert glycogen to glucose. To avoid severe hypoglycemia, it is crucial to keep oral feeding at intervals 2-3 hr for maintaining a normal blood sugar level. The metabolic derangements of von Gierke's disease may result in serious complications in patients undergoing surgery and anesthesia. We report the anesthetic managements of a patient with von Gierke's disease in two operations with different encounters. PMID:16623410

  17. On conjugate families and Jeffreys priors for von Mises–Fisher distributions

    PubMed Central

    Hornik, Kurt; Grün, Bettina

    2013-01-01

    This paper discusses characteristics of standard conjugate priors and their induced posteriors in Bayesian inference for von Mises–Fisher distributions, using either the canonical natural exponential family or the more commonly employed polar coordinate parameterizations. We analyze when standard conjugate priors as well as posteriors are proper, and investigate the Jeffreys prior for the von Mises–Fisher family. Finally, we characterize the proper distributions in the standard conjugate family of the (matrix-valued) von Mises–Fisher distributions on Stiefel manifolds. PMID:23805026

  18. The von Restorff effect in rats (Rattus norvegicus).

    PubMed

    Reed, P; Richards, A

    1996-06-01

    Two experiments examined the functional equivalence of memory in the rat (Rattus norvegicus) with memory in humans for serially presented items. Memory was assayed with an 8-arm radial maze, in which rats were allowed access to 5 arms of the maze and were then removed. Following a retention interval of 16 min, the rats were replaced in the maze and allowed to retrieve pellets from the 3 unvisited arms. The errors in reentering previously visited arms were noted. Both primacy and recency effects were found as with humans. Presenting a stimulus change after entry to 1 of the maze arms improved recall for that arm relative to when no change occurred. This effect was found using both handling and tone cues, and irrespective of whether the change consisted of presentation or nonpresentation of the cue. These results suggest that rats are subject to a von Restorff-like effect similar to that in humans.

  19. A Powerful Friendship: Theodore von Karman and Hugh L. Dryden

    NASA Technical Reports Server (NTRS)

    Gorn, Michael

    2003-01-01

    During their long personal friendship and professional association, Theodore von Karman (1882-1963) and Hugh L. Dryden (1898-1965) exercised a pivotal if somewhat elusive influence over American aeronautics and spaceflight. Both decisive figures in organizing scientists and engineers at home and abroad, both men of undisputed eminence in their technical fields, their range of contacts in government, academia, the armed forces, industry, and professional societies spanned the globe to an extent unparalleled then as now. Moreover, because they coordinated their activities closely, their combined influence far exceeded the sum of each one s individual contributions. This paper illustrates their personal origins as well as the foundations of their friendship, how their relationship became a professional alliance, and their joint impact on the world of aeronautics and astronautics during the twentieth century.

  20. Voluntarism in early psychology: the case of Hermann von Helmholtz.

    PubMed

    De Kock, Liesbet

    2014-05-01

    The failure to recognize the programmatic similarity between (post-)Kantian German philosophy and early psychology has impoverished psychology's historical self-understanding to a great extent. This article aims to contribute to recent efforts to overcome the gaps in the historiography of contemporary psychology, which are the result of an empiricist bias. To this end, we present an analysis of the way in which Hermann von Helmholtz's theory of perception resonates with Johann Gottlieb Fichte's Ego-doctrine. It will be argued that this indebtedness is particularly clear when focusing on the foundation of the differential awareness of subject and object in perception. In doing so, the widespread reception of Helmholtz's work as proto-positivist or strictly empiricist is challenged, in favor of the claim that important elements of his theorizing can only be understood properly against the background of Fichte's Ego-doctrine.

  1. Franz von Leydig (1821-1908), pioneer of comparative histology.

    PubMed

    Schneider, Marlon R

    2012-05-01

    Franz von Leydig, a German histologist and zoologist, is known to every student of human or animal anatomy because of the testicular testosterone-producing cells carrying his name. However, he made many contributions to our knowledge of the fine structure of animal tissues, including more than 200 scientific articles and several books. His most important work, the book Lehrbuch der Histologie des Menschen und der Thiere, established him as a pioneer if not the founder of comparative histology. Leydig taught at three different universities (Würzburg, Tübingen and Bonn) and received many honours from scientific organizations worldwide, including the Royal Society. He died in Rothenburg ob der Tauber, the town of his birth, aged 86 years.

  2. ADAMTS13 and von Willebrand Factor in Thrombotic Thrombocytopenic Purpura

    PubMed Central

    Zheng, X. Long

    2015-01-01

    Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular injury. Deficiency of plasma ADAMTS13 activity (<10%) resulting from mutations of the ADAMTS13 gene or autoantibodies against ADAMTS13 causes hereditary or acquired (idiopathic) TTP. ADAMTS13 activity is usually normal or modestly reduced (>20%) in other forms of thrombotic microangiopathy secondary to hematopoietic progenitor cell transplantation, infection, and disseminated malignancy or in hemolytic uremic syndrome. Plasma infusion or exchange remains the initial treatment of choice to date, but novel therapeutics such as recombinant ADAMTS13 and gene therapy are under development. Moreover, ADAMTS13 deficiency has been shown to be a risk factor for the development of myocardial infarction, stroke, cerebral malaria, and preeclampsia. PMID:25587650

  3. Immunogold labelling of human von Willebrand factor adsorbed to collagen.

    PubMed

    Furlan, M; Robles, R; Lämmle, B; Zimmermann, J; Hunziker, E

    1991-06-01

    von Willebrand factor (vWF) mediates adhesion of platelets to the exposed subendothelium at sites of vascular injury. This function is expressed through binding of vWF to both collagen and receptors on the platelet membrane. We have developed a new method using immunogold staining and electron microscopy, permitting visualization of human vWF adsorbed to collagen fibrils. The electron micrographs revealed strings of gold beads reflecting the polymeric structure of vWF. Our data showed dramatic differences in the binding of vWF to collagens of different sources: high binding density was observed using a collagen preparation isolated from aortic tissue whereas colloidal gold was virtually absent from tendon collagen. Using the immunogold labelling method we demonstrated that high shear rate enhanced vWF binding to aortic collagen.

  4. Ludwig von Bertalanffy's organismic view on the theory of evolution.

    PubMed

    Drack, Manfred

    2015-03-01

    Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented.

  5. Stochastic resonance in a generalized Von Foerster population growth model

    SciTech Connect

    Lumi, N.; Mankin, R.

    2014-11-12

    The stochastic dynamics of a population growth model, similar to the Von Foerster model for human population, is studied. The influence of fluctuating environment on the carrying capacity is modeled as a multiplicative dichotomous noise. It is established that an interplay between nonlinearity and environmental fluctuations can cause single unidirectional discontinuous transitions of the mean population size versus the noise amplitude, i.e., an increase of noise amplitude can induce a jump from a state with a moderate number of individuals to that with a very large number, while by decreasing the noise amplitude an opposite transition cannot be effected. An analytical expression of the mean escape time for such transitions is found. Particularly, it is shown that the mean transition time exhibits a strong minimum at intermediate values of noise correlation time, i.e., the phenomenon of stochastic resonance occurs. Applications of the results in ecology are also discussed.

  6. SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor

    PubMed Central

    Zhu, Qiuyu; Yamakuchi, Munekazu; Lowenstein, Charles J.

    2015-01-01

    Endothelial exocytosis regulates vascular thrombosis and inflammation. The trafficking and release of endothelial vesicles is mediated by SNARE (Soluble NSF Attachment protein REceptors) molecules, but the exact identity of endothelial SNAREs has been unclear. Three SNARE molecules form a ternary complex, including isoforms of the syntaxin (STX), vesicle-associated membrane protein (VAMP), and synaptosomal-associated protein (SNAP) families. We now identify SNAP23 as the predominant endothelial SNAP isoform that mediates endothelial exocytosis of von Willebrand Factor (VWF). SNAP23 was localized to the plasma membrane. Knockdown of SNAP23 decreased endothelial exocytosis, suggesting it is important for endothelial exocytosis. SNAP23 interacted with the endothelial exocytic machinery, and formed complexes with other known endothelial SNARE molecules. Taken together, these data suggest that SNAP23 is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis. PMID:26266817

  7. John von Neumann and Klaus Fuchs: an Unlikely Collaboration

    NASA Astrophysics Data System (ADS)

    Bernstein, Jeremy

    2010-03-01

    I discuss the origin of the idea of making a fusion (hydrogen) bomb and the physics involved in it, and then turn to the design proposed for one by the unlikely collaborators John von Neumann and Klaus Fuchs in a patent application they filed at Los Alamos in May 1946, which Fuchs passed on to the Russians in March 1948, and which with substantial modifications was tested on the island of Eberiru on the Eniwetok atoll in the South Pacific on May 8, 1951. This test showed that the fusion of deuterium and tritium nuclei could be ignited, but that the ignition would not propagate because the heat produced was rapidly radiated away. Meanwhile, Stanislaw Ulam and C.J. Everett had shown that Edward Teller’s Classical Super could not work, and at the end of December 1950, Ulam had conceived the idea of super compression, using the energy of a fission bomb to compress the fusion fuel to such a high density that it would be opaque to the radiation produced. Once Teller understood this, he invented a greatly improved, new method of compression using radiation, which then became the heart of the Ulam-Teller bomb design, which was tested, also in the South Pacific, on November 1, 1952. The Russians have freely acknowledged that Fuchs gave them the fission bomb, but they have insisted that no one gave them the fusion bomb, which grew out of design involving a fission bomb surrounded by alternating layers of fusion and fission fuels, and which they tested on November 22, 1955. Part of the irony of this story is that neither the American nor the Russian hydrogen-bomb programs made any use of the brilliant design that von Neumann and Fuchs had conceived as early as 1946, which could have changed the entire course of development of both programs.

  8. Dynamics of Diffusion Flames in von Karman Swirling Flows Studied

    NASA Technical Reports Server (NTRS)

    Nayagam, Vedha; Williams, Forman A.

    2002-01-01

    Von Karman swirling flow is generated by the viscous pumping action of a solid disk spinning in a quiescent fluid media. When this spinning disk is ignited in an oxidizing environment, a flat diffusion flame is established adjacent to the disk, embedded in the boundary layer (see the preceding illustration). For this geometry, the conservation equations reduce to a system of ordinary differential equations, enabling researchers to carry out detailed theoretical models to study the effects of varying strain on the dynamics of diffusion flames. Experimentally, the spinning disk burner provides an ideal configuration to precisely control the strain rates over a wide range. Our original motivation at the NASA Glenn Research Center to study these flames arose from a need to understand the flammability characteristics of solid fuels in microgravity where slow, subbuoyant flows can exist, producing very small strain rates. In a recent work (ref. 1), we showed that the flammability boundaries are wider and the minimum oxygen index (below which flames cannot be sustained) is lower for the von Karman flow configuration in comparison to a stagnation-point flow. Adding a small forced convection to the swirling flow pushes the flame into regions of higher strain and, thereby, decreases the range of flammable strain rates. Experiments using downward facing, polymethylmethacrylate (PMMA) disks spinning in air revealed that, close to the extinction boundaries, the flat diffusion flame breaks up into rotating spiral flames (refs. 2 and 3). Remarkably, the dynamics of these spiral flame edges exhibit a number of similarities to spirals observed in biological systems, such as the electric pulses in cardiac muscles and the aggregation of slime-mold amoeba. The tail of the spiral rotates rigidly while the tip executes a compound, meandering motion sometimes observed in Belousov-Zhabotinskii reactions.

  9. von Neumann's Law: Theoretical and Microgravity Experimental Comparison for Coarsening Diffusion in Bubble Lattices

    NASA Technical Reports Server (NTRS)

    Noever, David A.

    2000-01-01

    The effects of gravity in influencing the theoretical limit for bubble lattice coarsening and aging behavior, otherwise called von Neumann's law, is examined theoretically and experimentally. Preliminary microgravity results will be discussed.

  10. Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease

    PubMed Central

    Campbell, Victoria; Marriott, Kevin; Stanbridge, Rex; Shlebak, Abdul

    2015-01-01

    von Willebrand disease type 3 (VWD3) is a rare but the most severe form of von Willebrand disease; it is due to almost complete lack of von Willebrand factor activity (VWF:RCo). It is inherited as autosomal recessive trait; whilst heterozygote carriers have mild, or no symptoms, patients with VWD3 show severe bleeding symptoms. In the laboratory, this is characterised by undetectable VWF:Ag, VWF:RCo, and reduced levels of factor VIII < 0.02 IU/dL. The bleeding is managed with von Willebrand/FVIII factor concentrate replacement therapy. In this rare but challenging case we report on the successful excision and repair of an ascending aortic aneurysm following adequate VWF/FVIII factor concentrate replacement using Haemate-P. PMID:25960895

  11. President Kennedy, Vice President Johnson and Dr. von Braun at Redstone Airfield

    NASA Technical Reports Server (NTRS)

    1962-01-01

    President John F. Kennedy, Vice President Lyndon B. Johnson and Marshall Space Flight Center Director Dr. Wernher von Braun at the Redstone Arsenal Airfield, September 11, 1962. Kennedy and Johnson visited the Marshall Center to tour national space facilities.

  12. Wilhelm Julius Foerster und die "Vereinigung von Freunden der Astronomie und kosmischen Physik" (1891 bis 1914).

    NASA Astrophysics Data System (ADS)

    Tiemann, K.-H.

    Am 19. Mai 1891 wurde ins Leben gerufen die "Vereinigung von Freunden der Astronomie und der kosmischen Physik (nachfolg.: V.A.P.) - eine der beiden institutionellen Vorläufer der sich 1953 konstituierenden "Vereinigung der Sternfreunde".

  13. APOLLO 14 DR. WERNHER VON BRAUN WATCHES FROM FIRING ROOM 2

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Dr. Wernher von Braun, the NASA Deputy Associate Administrator for Future Programs, uses binoculars to monitor data on closed- circuit television screens in Firing Room 2 of the Launch Control Center during final Apollo 14 launch preparations today.

  14. Dr. Wernher Von Braun leads a tour of the S-IC checkout area.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Eberhard Rees, Charles Schultze, James Webb, Elmer Staats, Comptroller General of the United States, and Dr. Wernher Von Braun tour the S-IC checkout area in the Marshall Space Flight Center quality lab.

  15. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.

    PubMed

    James, A H; Konkle, B A; Kouides, P; Ragni, M V; Thames, B; Gupta, S; Sood, S; Fletcher, S K; Philipp, C S

    2015-01-01

    The aim of this study was to elucidate the fall in von Willebrand factor (VWF) and factor VIII activity (FVIII) after childbirth in women with and without von Willebrand disease (VWD). VWF:RCo, VWF:Ag, and FVIII were obtained in the third trimester of pregnancy, on admission for childbirth, and 10 times postpartum. Specimens were processed within 4 h and analysed centrally. Means were calculated at each time point. Forty women (40 pregnancies) without VWD and 32 women (35 pregnancies) with VWD were enrolled. 15/32 with VWD were treated (30% of those with type 1 and all of those with type 2) in 17 pregnancies. Treatments prior to delivery consisted of desmopressin (2/17), VWF concentrate (15/17) and after delivery VWF concentrate (16/17). Duration of treatment was 0-21 days (median 6). VWF levels peaked at 250% of baseline--4 h postpartum in women with VWD and 12 h postpartum in women without VWD. Thereafter, VWF levels fell rapidly, approached baseline at 1 week and reached baseline at 3 weeks. Except immediately postpartum, when the levels among treated cases were higher, levels among women with VWD appeared to parallel, but were lower than those among women without VWD. Levels were lowest among those who received treatment. VWF levels fall rapidly after childbirth. Except immediately postpartum, current treatment strategies do not raise VWF levels to the levels of women without VWD or even to the levels of women with milder, untreated VWD. Consequently, women with VWD may be at risk of postpartum haemorrhage despite treatment.

  16. In memory of Eugene (Jenő) von Gothard: a pioneering nineteenth century Hungarian astrophysicist

    NASA Astrophysics Data System (ADS)

    Vincze, Ildikő J.; Jankovics, István

    2012-07-01

    Eugene von Gothard was a Hungarian engineer/scientist, instrument-maker and astrophysicist who founded the Herény Astrophysical Observatory in 1881 and carried out pioneering work in astronomical photography and spectroscopy. In this paper we provide biographical material about von Gothard and describe his observatory, before discussing his astronomical observations and the contribution that hemade to the early development of astrophysics.

  17. Neuere Untersuchungen zur Prädiktion von EEG-Signalen bei Epilepsie

    NASA Astrophysics Data System (ADS)

    Niederhöfer, C.; Tetzlaff, R.

    2007-06-01

    Seit einigen Jahren ist die Analyse von EEG-Signalen bei Epilepsie Gegenstand zahlreicher wissenschaftlicher Arbeiten; Zielvorstellung ist dabei die Entwicklung von Verfahren zur Erkennung eines möglichen Voranfallszustandes. Im Vordergrund steht beispielsweise die Approximation einer so genannten effektiven Korrelationsdimension, die Bestimmung der maximalen Lyapunov-Exponenten, Detektionsverfahren für Muster bei Zellularen Nichtlinearen Netzwerken, die Bestimmung der mittleren Phasenkohärenz und Verfahren zur nichtlinearen Prädiktion von EEG-Signalen. Trotz umfangreicher Bemühungen kann bis heute eine Erkennung von Anfallsvorboten mit einer Sensitivität und Spezifität, die eine automatisierte Anfallsvorhersage ermöglichen würde, noch nicht durchgeführt werden. In diesem Beitrag werden neue Ergebnisse zur Prädiktion von EEG-Signalen bei Epilepsie vorgestellt. Dabei werden Signale, welche mittels intrakranieller electrocorticographischer (ECoG) und stereoelectroencephalographischer (SEEG) Ableitungen registriert wurden, segmentweise analysiert. Unter der Annahme, dass sich Änderungen des Systems ,,Gehirn" als Änderungen im Prädiktor, d.h. in seinen Systemparametern widerspiegeln, könnte eine nähere Betrachtung der Prädiktoreigenschaften zu einer Erkennung von Anfallsvorboten führen.

  18. Fibroblast growth factor-10 signals development of von Brunn's nests in the exstrophic bladder.

    PubMed

    Eastman, Rocky; Leaf, Elizabeth M; Zhang, Dianzhong; True, Lawrence D; Sweet, Robert M; Seidel, Kristy; Siebert, Joseph R; Grady, Richard; Mitchell, Michael E; Bassuk, James A

    2010-11-01

    von Brunn's nests have long been recognized as precursors of benign lesions of the urinary bladder mucosa. We report here that von Brunn's nests are especially prevalent in the exstrophic bladder, a birth defect that predisposes the patient to formation of bladder cancer. Cells of von Brunn's nest were found to coalesce into a stratified, polarized epithelium which surrounds itself with a capsule-like structure rich in types I, III, and IV collagen. Histocytochemical analysis and keratin profiling demonstrated that nested cells exhibited a phenotype similar, but not identical, to that of urothelial cells of transitional epithelium. Immunostaining and in situ hybridization analysis of exstrophic tissue demonstrated that the FGF-10 receptor is synthesized and retained by cells of von Brunn's nest. In contrast, FGF-10 is synthesized and secreted by mesenchymal fibroblasts via a paracrine pathway that targets basal epithelial cells of von Brunn's nests. Small clusters of 10pRp cells, positive for both FGF-10 and its receptor, were observed both proximal to and inside blood vessels in the lamina propria. The collective evidence points to a mechanism where von Brunn's nests develop under the control of the FGF-10 signal transduction system and suggests that 10pRp cells may be the original source of nested cells.

  19. Bayesian estimation of slip distribution based on von Karman autocorrelation

    NASA Astrophysics Data System (ADS)

    Hooper, A. J.; Bekaert, D. P.

    2014-12-01

    Geodetic observations from techniques such as InSAR and GNSS are routinely used to invert for earthquake fault slip distributions. However, in order to regularize the inversions, extra arbitrary assumptions about the smoothness of the slip distribution are usually included. In previous work we explored a new approach for constraining the slip distribution based on a random vector model following a von Karman autocorrelation function, which has empirical support from a stochastic analysis of seismic finite-source slip inversions. We implemented the random vector constraint in a Bayesian fashion and used a Markov chain Monte Carlo (MCMC) algorithm to derive the posterior joint probability distribution for each of the slipping patches. The von Karman function depends on two parameters: correlation length and Hurst number (related to fractal dimension). In our inversions we used the empirically derived maximum likelihood values for these two parameters, which differ in along-strike and down-dip directions, and with fault mechanism. However, the inversion results depend strongly on the chosen values for correlation length and Hurst number, and the empirically derived histograms show that there is in fact quite some variation between earthquakes with the same mechanism. In our extended approach we treat these two parameters as hyperparameters, with the prior probability distribution constrained by the empirical histograms. The values are thus also allowed to vary in our Bayesian inversion scheme. In this way, the uncertainty in the parameters that define the autocorrelation function is also included in the posterior probability distribution for the slipping patches. To ensure that our MCMC algorithm converges rapidly, we have implemented a variation to the usual MCMC approach, in which the maximum step size for each of the model parameters is initially updated regularly, until optimal values are achieved. In comparisons between our new approach and a more standard

  20. Edge-Flames in Von Karman Swirling Flows

    NASA Technical Reports Server (NTRS)

    Nayagam, Vedha; Williams, Forman A.

    1999-01-01

    Classical understanding of diffusion flames dictates that they, unlike the premixed flames, do not possess a characteristic propagation velocity and are constrained by stoichiometric requirements at the flame surface. However, it has been commonly observed that when local extinction occurs within a diffusion flame sheet, the edges that are formed propagate with distinct speeds. In general, the propagation speed of these edges depend on their geometrical shape (concave, convex, or straight) among other factors. Recently, Buckmaster investigated the dynamics of straight diffusion flame edges separating burning and quenched regions using simplified one-dimensional models. He showed that these flame edges can have positive, negative, or zero velocity depending on the Damkoehler number of the equilibrium diffusion flame that support them. It was also shown that this unsteady flame-edge behavior is intrinsically linked to S-curve behavior of the diffusion flame with varying Damkoehler number. When the system Damkoehler number lies between the extinction and ignition limits, flame edges can propagate as an "ignition wave" or as a "failure wave," and for a critical Damkoehler number remain as a stationary flame-edge. We have extend Buckmaster's 1-d model to more general edge-flame configurations where the edges appear as "flame holes" or as "flame disks". These two configurations along with the straight-edge case cover the entire range of possible edge-flame geometry observable in planar diffusion-flame sheets. A generalized map of edge-flame propagation velocities as a function of the system Damkoehler number and the edge-flame radius is presented. Experimentally we show that edge flames can be created using diffusion flames embedded in von Karman boundary layers. In a von Karman boundary layer, the flow is generated by spinning a solid (fuel) disk in a quiescent ambient gas. Under normal gravity we were able to produce "flame disks" over a range of fuel-disk rotational

  1. Schirmwirkung von Hochfrequenz (HF)-Schutzkleidung: Untersuchung verschiedener Konstruktionsmerkmale

    NASA Astrophysics Data System (ADS)

    Arps, V.; Scheibe, K.

    2005-05-01

    Die Messverfahren zur Bestimmung der Schutzwirkung von HF-Schutzkleidung sind in der Norm DIN 32780-100 festgelegt. Entsprechend diesen Anforderungen wird die elektrische und magnetische Schirmdämpfung bestimmt und daraus als Maß für die Schutzwirkung die elektromagnetische Schirmdämpfung berechnet. Diese ist eine der SAR vergleichbare Größe. In diesem Beitrag werden die Einflüsse verschiedener Konstruktionsmerkmale von HF-Schutzanzügen auf die elektromagnetische Schirmdämpfung untersucht. Zu diesen gehören die nach MIL STD 285 vermessene elektrische Schirmdämpfung der verwendeten Gewebe. Weiter werden verschiedene Teilbereiche der HF-Schutzkleidung auf ihre Schutzwirkung untersucht. Der Schwerpunkt liegt hierbei auf der Fragestellung inwieweit Verschlüsse, Reißverschlüsse oder leitfähiges Klettband, die Schutzwirkung beeinträchtigen. Zu diesem Zweck werden zwei Schutzanzüge unterschiedlicher Konstruktion vergleichend vermessen. Es handelt sich dabei um einen bereits im Handel befindlichen und entsprechend der Norm zertifizierten Anzug und einen neuen Prototyp, welcher nach verschiedenen Gesichtspunkten optimiert wurde. Schwachstellen der Konstruktion werden herausgearbeitet und Ansatzpunkte für weitere Verbesserungen erarbeitet. The measuring methods for determining the shielding effectiveness of radiofrequency (RF)-protective clothing are defined in German Standard DIN 32780-100. According to this standard, both the electric and the magnetic shielding effectiveness are measured in order to calculate the electromagnetic shielding effectiveness. The electromagnetic shielding effectiveness is an adequate quality criterion for the degree of protection and also compares well with the Specific Absorption Rate (SAR). In this article, the impact of different design features on the electromagnetic shielding effectiveness is analyzed. The electric shielding effectiveness of the used shielding materials is measured according to MIL STD 285 and thereupon

  2. Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease.

    PubMed

    Shively, Sharon B; Falke, Eric A; Li, Jie; Tran, Maxine G B; Thompson, Eli R; Maxwell, Patrick H; Roessler, Erich; Oldfield, Edward H; Lonser, Russell R; Vortmeyer, Alexander O

    2011-08-01

    There is increasing evidence that suggests that knockout of tumor-suppressor gene function causes developmental arrest and protraction of cellular differentiation. In the peripheral nervous system of patients with the tumor-suppressor gene disorder, von Hippel-Lindau disease, we have demonstrated developmentally arrested structural elements composed of hemangioblast progenitor cells. Some developmentally arrested structural elements progress to a frank tumor, hemangioblastoma. However, in von Hippel-Lindau disease, hemangioblastomas are frequently observed in the cerebellum, suggesting an origin in the central nervous system. We performed a structural and topographic analysis of cerebellar tissues obtained from von Hippel-Lindau disease patients to identify and characterize developmentally arrested structural elements in the central nervous system. We examined the entire cerebella of five tumor-free von Hippel-Lindau disease patients and of three non-von Hippel-Lindau disease controls. In all, 9 cerebellar developmentally arrested structural elements were detected and topographically mapped in 385 blocks of von Hippel-Lindau disease cerebella. No developmentally arrested structural elements were seen in 214 blocks from control cerebella. Developmentally arrested structural elements are composed of poorly differentiated cells that express hypoxia-inducible factor (HIF)2α, but not HIF1α or brachyury, and preferentially involve the molecular layer of the dorsum cerebelli. For the first time, we identify and characterize developmentally arrested structural elements in the central nervous system of von Hippel-Lindau patients. We provide evidence that developmentally arrested structural elements in the cerebellum are composed of developmentally arrested hemangioblast progenitor cells in the molecular layer of the dorsum cerebelli.

  3. Distinguishability of countable quantum states and von Neumann lattice

    NASA Astrophysics Data System (ADS)

    Kawakubo, Ryûitirô; Koike, Tatsuhiko

    2016-07-01

    The condition for distinguishability of a countably infinite number of pure states by a single measurement is given. Distinguishability is to be understood as the possibility of an unambiguous measurement. For a finite number of states, it is known that the necessary and sufficient condition of distinguishability is that the states are linearly independent. For an infinite number of states, several natural classes of distinguishability can be defined. We give a necessary and sufficient condition for a system of pure states to be distinguishable. It turns out that each level of distinguishability naturally corresponds to one of the generalizations of linear independence to families of infinite vectors. As an important example, we apply the general theory to von Neumann’s lattice, a subsystem of coherent states which corresponds to a lattice in the classical phase space. We prove that the condition for distinguishability is that the area of the fundamental region of the lattice is greater than the Planck constant, and also find subtle behavior on the threshold. These facts reveal the measurement theoretical meaning of the Planck constant and give a justification for the interpretation that it is the smallest unit of area in the phase space. The cases of uncountably many states and of mixed states are also discussed.

  4. Scaling of Von Neumann Entropy at the Anderson Transition

    NASA Astrophysics Data System (ADS)

    Chakravarty, Sudip

    Extensive body of work has shown that for the model of a non-interacting electron in a random potential there is a quantum critical point for dimensions greater than two — a metal-insulator transition. This model also plays an important role in the plateau-to-plateu transition in the integer quantum Hall effect, which is also correctly captured by a scaling theory. Yet, in neither of these cases the ground state energy shows any non-analyticity as a function of a suitable tuning parameter, typically considered to be a hallmark of a quantum phase transition, similar to the non-analyticity of the free energy in a classical phase transition. Here we show that von Neumann entropy (entanglement entropy) is non-analytic at these phase transitions and can track the fundamental changes in the internal correlations of the ground state wave function. In particular, it summarizes the spatially wildly fluctuating intensities of the wave function close to the criticality of the Anderson transition. It is likely that all quantum phase transitions can be similarly described.

  5. Empathy and identification in Von Donnersmarck's The Lives of Others.

    PubMed

    Diamond, Diana

    2008-09-01

    Florian Henckel von Donnersmarck's The Lives of Others, set in the German Democratic Republic in 1984, five years before the fall of the Berlin Wall, has been called the first accurate depiction of the psychological terror wielded by the Stasi, the East German secret police, who safeguarded the dictatorship of the proletariat. The film is about the psychological and political transformation of a Stasi officer, Wiesler, who undertakes the surveillance of a prominent playwright and his actress lover. The mechanisms through which Wiesler comes to empathize and identify with the subjects of his investigation, as he observes and listens in on the rich blend of passion, poetry, and politics that characterizes their lives, are explored in depth. Wiesler's transformation is based in part on the capacity to form implicit models of the behavior and experiences of others, based on the mirror neuron system, that Gallese and his colleagues call "embodied simulation." Underpinning the processes of empathy and identification so central to this film, embodied simulation is an unconscious and prereflexive mechanism through which the actions, emotions, and sensations we observe activate internal representations of the bodily and mental states of the other. Embodied simulation also expands our understanding of the power of the primal scene, which has long been identified as a major organizer of unconscious fantasies and conflicts throughout life, and which forms the central metaphor of the film. Embodied simulation scaffolds our aesthetic response to art, music, and literature, underlies the dynamics of spectatorship, and potentially catalyzes resistance to totalitarian mass movements. PMID:18802131

  6. Von recklinghausen disease: one patient – various problems

    PubMed Central

    Miziołek, B; Brzezińska-Wcisło, L

    2016-01-01

    Abstract von Recklinghausen disease (vRD), more widely known as neurofibromatosis type 1, belongs to a group of genetic disorders and it is considered to be the most common genodermatosis. The disease has an autosomal dominant pattern of inheritance that involves mutations within the NF1 gene located on chromosome 17 in locus q11.2. The product of the NF1 gene is neurofibromin and the protein is well known to be a tumor suppressor factor. This counteracts possible overactivity of RAS (protein)/MAPK (mitogen-activated protein kinase) and RAS/PI3K/AKT/mTOR (phoshatydyloinositol-3-kinase/V-akt murine thy-moma viral oncogene homologue/mammalian target of rapamycin) signaling transduction pathways, preventing from uncontrolled cell proliferation and subsequent tumor formation. A loss of proper functioning of this protein leads to a development of vRD; however, a large variability in a phenotype of the disease and the onset of cutaneous findings, not necessarily in childhood, may provide a clinical diagnosis of the disease late in adulthood. We present a 52-year-old male in whom the diagnosis of vRD was proposed in the sixth decade of life, despite of multiple nodular lesions disseminated over the skin of the whole body and different neurological disturbances, not considered for a long time as manifestations of genodermatosis.

  7. Front End Schaltung zur Online Auswertung von EKG-Signalen

    NASA Astrophysics Data System (ADS)

    Ayari, E.; Tielert, R.

    2007-06-01

    Ein mobiles EKG-System zur Online Auswertung von EKG-Signalen wird dargestellt. Die Auswertung beruht auf ein energiesparendes Verfahren, das den Vorteil einer zulässigen Unterabtastung des Signals bietet und eine Interaktion zwischen der messenden Elektronik und dem funkgebundenen Auswertungsrechner ermöglicht. Diese Interaktion besteht darin, sowohl die Front End Schaltung im EKG-Sensor als auch den im ATmega8L eingebetteten A/D-Wandler vom Auswertungsrechner zu steuern und den Datenbedarf des Rechners dynamisch an die Erfordernisse des Analyseprogramms anzupassen. Das entwickelte EKG-System liefert erfolgreiche Charakterisierungen erfasster Elektrokardiogramme. A mobile ecg-system for an online analysis of electrocardiogram signals is presented. The analysis is based on an energy-saving procedure, which offers the advantage of an acceptable undersampling of the signal, and which allows an interaction between the measuring electronic and the radio-bound analysis-computer. In this interaction both the front-end circuit in the ecg-sensor and the A/D converter, which is embedded in the ATmega8L, are steered by the analysis computer. The data requirement of the computer is also dynamically adapted to the requirements of the analysis-program. The developed ecg-system supplies successful characterisations of measured electrocardiograms.

  8. [Hermann von Helmholtz and Carl Stumpf on consonance and dissonance].

    PubMed

    Kursell, Julia

    2008-06-01

    The article juxtaposes Hermann von Helmholtz's work in the experimental physiology of hearing and Carl Stumpf's tone psychology, focusing on the problem of consonance and dissonance in music. It argues that the experimental set-up plays a major role in the approaches to hearing of both Helmholtz and Stumpf, shaping their redefinition of the musical concepts of consonance and dissonance. Helmholtz, however, explains dissonance as resulting from the beats that are heard when sound waves interfere, while Stumpf explains consonance from the fusion (Verschmelzung) of sounds, noting that two tones, depending on their distance cannot always be recognized as two but are heard as one single tone. Helmholtz's definition of dissonance eventually threatens his own theory of hearing, which is based on the mechanical principle of resonance and considers sound to be composed of sinusoidal waves. Both the physical and the mathematical tools he uses cannot easily be brought into accordance with his experimental findings on beats, which ask for a discrimination of fast changes in intensity. Dissonance thus becomes "unrecomendable" for Helmholtz, because it overstrains the ear. Stumpf's research, in contrast, has its point of departure in the historically given set of intervals and tries to find a principle that would explain this choice. His tests with experimental subjects who have no conscious knowledge of musical harmony and prove incapable to follow or reproduce music reveals to him a difference between the unity and multiplicity of tones.

  9. Cooperation within von Willebrand factors enhances adsorption mechanism.

    PubMed

    Heidari, Maziar; Mehrbod, Mehrdad; Ejtehadi, Mohammad Reza; Mofrad, Mohammad R K

    2015-08-01

    von Willebrand factor (VWF) is a naturally collapsed protein that participates in primary haemostasis and coagulation events. The clotting process is triggered by the adsorption and conformational changes of the plasma VWFs localized to the collagen fibres found near the site of injury. We develop coarse-grained models to simulate the adsorption dynamics of VWF flowing near the adhesive collagen fibres at different shear rates and investigate the effect of factors such as interaction and cooperativity of VWFs on the success of adsorption events. The adsorption probability of a flowing VWF confined to the receptor field is enhanced when it encounters an adhered VWF in proximity to the collagen receptors. This enhancement is observed within a wide range of shear rates and is mostly controlled by the attractive van der Waals interactions rather than the hydrodynamic interactions among VWF monomers. The cooperativity between the VWFs acts as an effective mechanism for enhancing VWF adsorption to the collagen fibres. Additionally, this implies that the adsorption of such molecules is nonlinearly dependent on the density of flowing VWFs. These findings are important for studies of primary haemostasis as well as general adsorption dynamics processes in polymer physics.

  10. Multiple von Neumann computers: an evolutionary approach to functional emergence.

    PubMed

    Suzuki, H

    1997-01-01

    A novel system composed of multiple von Neumann computers and an appropriate problem environment is proposed and simulated. Each computer has a memory to store the machine instruction program, and when a program is executed, a series of machine codes in the memory is sequentially decoded, leading to register operations in the central processing unit (CPU). By means of these operations, the computer not only can handle its generally used registers but also can read and write the environmental database. Simulation is driven by genetic algorithms (GAs) performed on the population of program memories. Mutation and crossover create program diversity in the memory, and selection facilitates the reproduction of appropriate programs. Through these evolutionary operations, advantageous combinations of machine codes are created and fixed in the population one by one, and the higher function, which enables the computer to calculate an appropriate number from the environment, finally emerges in the program memory. In the latter half of the article, the performance of GAs on this system is studied. Under different sets of parameters, the evolutionary speed, which is determined by the time until the domination of the final program, is examined and the conditions for faster evolution are clarified. At an intermediate mutation rate and at an intermediate population size, crossover helps create novel advantageous sets of machine codes and evidently accelerates optimization by GAs.

  11. [Hans von Hattingberg between psychoanalysis and National Socialism].

    PubMed

    Keifenheim, Katharina Eva

    2011-01-01

    Hans von Hattingberg (1879-1944) worked as a neurologist and psychoanalyst in Munich and Berlin from about 1910 to 1944. He was a prolific writer, but met with increasing disapproval from Freud and his circle. An advocate of the union of different psychotherapeutic schools, he was initially a marginal figure in the professional field. With Hitler's rise to power his career prospered: He was offered the position of a lecturer for psychotherapy and became head of the research department at the "Göring Institute". He came to prominence with his writings on the "Neue deutsche Seelenheilkunde" despite the fact that this was never his preferred topic. The main themes of his publications were marriage, love and female emancipation. Those works contain only little of the standard Nazi ideology of the time. Not only was Hattingberg never a member of the NSDAP (the ruling party), but in some respects he could conceivably be considered a member of the resistance. The article outlines the most important stages of Hattingberg's life and focuses on the question of how he positioned himself after 1933, when it became vital for him to reconcile psychoanalysis and National Socialism.

  12. Empathy and identification in Von Donnersmarck's The Lives of Others.

    PubMed

    Diamond, Diana

    2008-09-01

    Florian Henckel von Donnersmarck's The Lives of Others, set in the German Democratic Republic in 1984, five years before the fall of the Berlin Wall, has been called the first accurate depiction of the psychological terror wielded by the Stasi, the East German secret police, who safeguarded the dictatorship of the proletariat. The film is about the psychological and political transformation of a Stasi officer, Wiesler, who undertakes the surveillance of a prominent playwright and his actress lover. The mechanisms through which Wiesler comes to empathize and identify with the subjects of his investigation, as he observes and listens in on the rich blend of passion, poetry, and politics that characterizes their lives, are explored in depth. Wiesler's transformation is based in part on the capacity to form implicit models of the behavior and experiences of others, based on the mirror neuron system, that Gallese and his colleagues call "embodied simulation." Underpinning the processes of empathy and identification so central to this film, embodied simulation is an unconscious and prereflexive mechanism through which the actions, emotions, and sensations we observe activate internal representations of the bodily and mental states of the other. Embodied simulation also expands our understanding of the power of the primal scene, which has long been identified as a major organizer of unconscious fantasies and conflicts throughout life, and which forms the central metaphor of the film. Embodied simulation scaffolds our aesthetic response to art, music, and literature, underlies the dynamics of spectatorship, and potentially catalyzes resistance to totalitarian mass movements.

  13. Ludwig von Bertalanffy's Organismic View on the Theory of Evolution

    PubMed Central

    Drack, Manfred

    2015-01-01

    Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 77–90, 2015. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals, Inc. PMID:25727202

  14. VASCULOGENESIS IN VON HIPPEL-LINDAU DISEASE ASSOCIATED TUMORS

    PubMed Central

    Lonser, Russell R.; Frerich, Jason; Huntoon, Kristin; Yang, Chunzhang; Merrill, Marsha; Abdullaev, Ziedulla; Pack, Svetlana; Shively, Sharon; Stamp, Gordon; Zhuang, Zhengping

    2014-01-01

    BACKGROUND: Emerging data indicate that von Hippel-Lindau disease (VHL) associated tumors arise from embryologic hemangioblasts that can form vessels (endothelial cells) and blood cells. Nevertheless, the origin of VHL-associated vasculature is not known. To determine the origin of VHL-associated tumor vasculature, we investigated the neoplastic vasculature from VHL patients. METHODS: Microdissected VHL-associated tumor (compared to control non-VHL tissues) vascular features were examined using immunohistochemical staining for CA9, HIF-2a, HIF-1a, CD31 and Factor VIIIa. Origin of tumor vascular elements (tumor versus non-tumor) was assessed by LOH and FISH analysis. Intratumoral vasculogenesis was assessed in vivo using the VHL-deficient UMRC6 renal carcinoma murine xenograft model. RESULTS: We demonstrate that isolated vascular structures and blood vessels within VHL-associated neoplasms (including hemangioblastomas, renal cell carcinoma and pancreatic tumors) are a result of tumor-derived vasculogenesis. Further, similar to hemangioblastomas, other VHL-associated neoplasms possess vascular tissue of tumor origin. Similarly, tumor-derived endothelial cells emerge within implanted VHL deficient UMRC6 renal cell carcinoma murine xenografts. CONCLUSIONS: These findings further establish the embryologic, developmentally arrested, hemangioblast as the tumor cell of origin for VHL-associated hemangioblastomas and indicate that it is also the progenitor cell for other VHL-associated tumors. SECONDARY CATEGORY: Neuropathology & Tumor Biomarkers.

  15. [Heinrich von Kleist--crisis and creative overcoming].

    PubMed

    Schlimme, J

    2001-07-01

    Heinrich von Kleist's life was shaken repeatedly by negative life-events, finally he committed suicide in his last life-crisis (1811). His work was mostly understood as descriptions of negative life-events and failed-being. In this article it will be shown that in at least two "crises" Kleist's work can be understood as a creative overcome of those. Kleist shows in his "Essay to Find a Sure Way to Happiness" (1799) his way of solving his "Soldier-Crisis" (1798), a depressive episode. In "The Broken Jug" (1802 - 1805) he shows the implications of a philosophical problem experienced in his "Kant-Crisis" (1801) and offers chances to overcome this particular crisis, which still seems to be an actual problem of ourselves. Though his crises must be understood as depressive episodes, at least the "Kant-Crisis" with its connections to philosophical and artistical matters seems to be more complicated than a simple depressive syndrome. Kleist formulates his basic life-experience, to be repeatedly shaken by "crises" respectively depressive episodes and the necessity to overcome each in a new way of living.

  16. Emperor Ashoka: Did he suffer from von Recklinghausen's diseases?

    PubMed Central

    Wig, N. N.; Sharma, Sheetal

    2015-01-01

    Emperor Ashoka is widely regarded as one of the greatest rulers of India. This paper mainly deals with his medical condition as recorded in the Buddhist texts of Sri Lanka as well as in the Buddhist texts of North India and Nepal. These sources mention his skin disorder which is described as very rough and unpleasant to touch. He is also known to have episodes of loss of consciousness at various times in his life. One of the earliest representations of Ashoka, about 100 years after his death at one of the gates of Sanchi Stupa, shows Ashoka fainting when visiting the Bodhi tree and being held by his queens. In this sculpture, Emperor Ashoka is shown as a man of short height, large head and a paunchy abdomen. In this paper, it is speculated that Emperor Ashoka was probably suffering from von Recklinghausen disease (Neurofibromatosis Type 1), which could explain his skin condition, episodes of loss of consciousness (probably epilepsy) and other bodily deformities. PMID:25657467

  17. Minimal Coupling in Koopman-von Neumann Theory

    NASA Astrophysics Data System (ADS)

    Gozzi, E.; Mauro, D.

    2002-03-01

    Classical mechanics (CM), like quantum mechanics (QM), can have an operatorial formulation. This was pioneered by Koopman and von Neumann (KvN) in the 1930s. They basically formalized, via the introduction of a classical Hilbert space, earlier work of Liouville who had shown that the classical time evolution can take place via an operator, nowadays known as the Liouville operator. In this paper we study how to perform the coupling of a point particle to a gauge field in the KvN version of CM. So we basically implement at the classical operatorial level the analog of the minimal coupling of QM. We show that, differently than in QM, not only the momenta but also other variables have to be coupled to the gauge field. We also analyze in detail how the gauge invariance manifests itself in the Hilbert space of KvN and indicate the differences with QM. As an application of the KvN method we study the Landau problem proving that there are many more degeneracies at the classical operatorial level than at the quantum one. As a second example we go through the Aharonov-Bohm phenomenon showing that, at the quantum level, this phenomenon manifests its effects on the spectrum of the quantum Hamiltonian while at the classical level there is no effect whatsoever on the spectrum of the Liouville operator.

  18. [Carl Friedrich von Weizsäcker - physicist and philosopher].

    PubMed

    Drieschner, Michael

    2014-01-01

    The subject of this paper is the philosopher Carl Friedrich von weizsäcker, especially under the aspect of the relation between physics and philosophy in his works. The decisive role of time in physics as well as in philosophy is described, and thereof is derived the comprehension of probability as a predicted relative frequency. Consequently quantum mechanics is interpreted as a theory of probability that uses "quantum logic" instead of classical propositional logic that is used in "normal" probability. The philosophical fruit of that is the interpretation of potentiality as the modality of the future. Weizsäcker's proposals for a justification of physics a priori are dealt with as well as his approach to a theory of "ur-objects", which are atoms in the strictest sense: q-bits.--Questions of Weizsäcker's personality are addressed: His role in the development of the nuclear reactor and atomic bomb in Nazi time, his enthusiasm and his religiousness as well as his efforts towards world peace.

  19. Early turbulence in von Karman swirling flow of polymer solutions

    NASA Astrophysics Data System (ADS)

    Burnishev, Yuri; Steinberg, Victor

    2015-01-01

    We present quantitative experimental results on the transition to early turbulence in von Karman swirling flow of water- and water-sugar-based polymer solutions compared to the transition to turbulence in their Newtonian solvents by measurements of solely global quantities as torque Γ(t) and pressure p(t) with large statistics as a function of Re. For the first time the transition values of Re_c\\textit{turb} to fully developed turbulence and turbulent drag reduction regime Re_c\\textit{TDR} are obtained as functions of elasticity El by using the solvents with different viscosities and polymer concentrations ϕ. Two scaling regions for fundamental turbulent characteristics are identified and they correspond to the turbulent and TDR regimes. Both Re_c\\textit{turb} and Re_c\\textit{TDR} are found via the dependence of the friction coefficient Cf and Cp, defined through scaled average torque \\barΓ and rms pressure fluctuations p\\textit{rms} , respectively, on Re for different El and ϕ and via the limits of the two scaling regions.

  20. von Willebrand factor binds to platelets and induces aggregation in platelet-type but not type IIB von Willebrand disease.

    PubMed Central

    Miller, J L; Kupinski, J M; Castella, A; Ruggeri, Z M

    1983-01-01

    Platelet-type von Willebrand disease (vWD) and pseudo-vWD are two recently described intrinsic platelet defects characterized by enhanced ristocetin-induced agglutination in platelet-rich plasma. A similar finding is also typical of type IIB vWD, where it has been related to a von Willebrand factor (vWF) rather than a platelet abnormality. Platelet aggregation induced by unmodified human vWF in the absence of other stimuli has been reported in pseudo-vWD. In this study we demonstrate that vWF induces aggregation in platelet-type but not type IIB vWD. Aggregation is observed when normal plasma cryoprecipitate or purified vWF are added to platelet-rich plasma. Cryoprecipitate also aggregates washed platelets, although at higher concentrations than required for platelet-rich plasma. Purified vWF, however, induces significant aggregation of washed platelets only when plasma is added. EDTA inhibits vWF-induced aggregation. Its effect can be overcome by calcium but much less effectively by magnesium ions. Unstimulated platelets in platelet-rich plasma from patients with platelet-type but not type IIB vWD bind 125I-vWF in a specific and saturable manner. All different sized multimers of vWF become associated with platelets. Both aggregation and binding exhibit a similar vWF concentration dependence, suggesting that a correlation exists between these two events. Removal of ADP by appropriate consuming systems is without effect upon such binding or upon vWF-induced aggregation. Thrombin-induced 125I-vWF binding to washed platelets is normal in platelet-type as well as type IIB vWD. These results demonstrate that a specific binding site for unmodified human vWF is exposed on unstimulated platelets in platelet-type vWD. The relatively high vWF concentrations required for aggregation and binding may explain the lack of significant in vivo aggregation and thrombocytopenia in these patients. Moreover, these studies provide additional evidence that platelet-type and type IIB v

  1. Test of Von Baer's law of the conservation of early development.

    PubMed

    Poe, Steven

    2006-11-01

    One of the oldest and most pervasive ideas in comparative embryology is the perceived evolutionary conservation of early ontogeny relative to late ontogeny. Karl Von Baer first noted the similarity of early ontogeny across taxa, and Ernst Haeckel and Charles Darwin gave evolutionary interpretation to this phenomenon. In spite of a resurgence of interest in comparative embryology and the development of mechanistic explanations for Von Baer's law, the pattern itself has been largely untested. Here, I use statistical phylogenetic approaches to show that Von Baer's law is an unnecessarily complex explanation of the patterns of ontogenetic timing in several clades of vertebrates. Von Baer's law suggests a positive correlation between ontogenetic time and amount of evolutionary change. I compare ranked position in ontogeny to frequency of evolutionary change in rank for developmental events and find that these measures are not correlated, thus failing to support Von Baer's model. An alternative model that postulates that small changes in ontogenetic rank are evolutionarily easier than large changes is tentatively supported. PMID:17236417

  2. [A case of chronic inflammatory demyelinating polyradiculoneuropathy concomitant with acquired von Willebrand syndrome].

    PubMed

    Ueda, Maki; Kawamura, Nobutoshi; Tateishi, Takahisa; Shigeto, Hiroshi; Ohyagi, Yasumasa; Kira, Jun-ichi

    2011-05-01

    We report a case of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) concomitant with acquired von Willebrand syndrome. A 33-year-old man developed motor and sensory polyneuropathy with electrophysiological conduction slowing. At this time, M-protein was absent He was diagnosed with CIDP and received intravenous immunoglobulin and subsequent oral corticosteroids, which resulted in almost complete remission for over 10 years. At the age of 44, he presented with chronic anemia. Laboratory tests and colonoscopy revealed that he had acquired von Willebrand syndrome with monoclonal gammopathy of undetermined significance (IgG lambda type) and colon cancer. Bleeding symptoms were.resolved with intravenous immunoglobulin, but not with supplementation of factor VIII. Shortly after successful excision of the cancer, CIDP and acquired von Willebrand syndrome simultaneously recurred. Intravenous immunoglobulin produced rapid improvement of both neurological and hematological abnormalities. Concurring CIDP and acquired von Willebrand syndrome in the present case may indicate that the conditions have a partly common immunological background including monoclonal gammopathy and a potential common autoantibody-mediated mechanism. Alternatively, dysfunction of von Willebrand factor may increase blood-nerve barrier permeability, inducing the recurrence of CIDP.

  3. Test of Von Baer's law of the conservation of early development.

    PubMed

    Poe, Steven

    2006-11-01

    One of the oldest and most pervasive ideas in comparative embryology is the perceived evolutionary conservation of early ontogeny relative to late ontogeny. Karl Von Baer first noted the similarity of early ontogeny across taxa, and Ernst Haeckel and Charles Darwin gave evolutionary interpretation to this phenomenon. In spite of a resurgence of interest in comparative embryology and the development of mechanistic explanations for Von Baer's law, the pattern itself has been largely untested. Here, I use statistical phylogenetic approaches to show that Von Baer's law is an unnecessarily complex explanation of the patterns of ontogenetic timing in several clades of vertebrates. Von Baer's law suggests a positive correlation between ontogenetic time and amount of evolutionary change. I compare ranked position in ontogeny to frequency of evolutionary change in rank for developmental events and find that these measures are not correlated, thus failing to support Von Baer's model. An alternative model that postulates that small changes in ontogenetic rank are evolutionarily easier than large changes is tentatively supported.

  4. BOOK REVIEW: Meilensteine der Astronomie - Von Aristoteles bis Hawking

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Hamel, J.

    2006-12-01

    A writer, more specific a writer on the history of astronomy, might from time to time look at the collected document folders with all the research material and reprints, and might wonder: has this been all? Especially at a time when recycling is in vogue? And, perhaps with a request or an invitation to submit something, he or she might consider re-using the material before its definitive disposal. Well, such are my feelings when I looked at Jurgen Hamel's new book Milestones of Astronomy - From Aristoteles to Hawking . A slight chance for survival of medium-sized publishers like Kosmos is to offer popular books, and a title must attract potential buyers: Aristoteles means the "old" times, and as concerns the "mad scientist" of modern times, Stephen Hawking has by now dethroned Einstein. In 1998, Hamel had published a Geschichte der Astronomie - Von den Anfangen bis zur Gegenwart (History of astronomy, from the beginnings to the present), which, of course, he could not simply copy. This time, he selected some stones from his research areas - milestones, touchstones, stumbling blocks in the long road of astronomical evolution - and put them between the covers of his new book. So let us look at these (mile)stones . The reader is informed about Aristoteles on 2 pages, but his medieval interpreter Johannes de Sacrobosco gets 8 pages! Copernicus' life and achievements are described on 9 pages, closely followed by his devotee and translator Rothmann with 8 pages; Copernicus' contemporary, Peter Apian, however, gets about 13! Bessel's and Herschel's lifes and works are described on well-deserved 13 and 15 pages, while the achievements of the two Lucasian professors, Isaac Newton and Stephen Hawking, are just outlined in a single paragraph! Thus, importance is sometimes inversely proportional to text length... But let us become serious now. Why should an active historian outline, for the hundreth time, the life of Copernicus, while there are so many interesting, and often

  5. Relating sensation seeking and the von Restorff Isolation Effect.

    PubMed

    Cimbalo, Richard S; Clark, Douglas; Matayev, Aleksandr I

    2003-06-01

    Sensation seeking was examined in a short-term memory task involving the serial recall of a 10-item list of consonants with (isolated) and without (non-isolated) a distinctively larger item in the fifth position. 126 students were given the Sensation Seeking Scale Form-V and 32 10-item lists to memorize in a 1 by 3 mixed design. Sensation seeking was a between-subject factor and Blocks (Trials 1-16 and 17-32), Isolation (isolated and nonisolated), and Duration (2 sec. and 10 sec.) were within-subject factors. Generally nonisolated lists and the larger letters (the von Restorff Isolation Effect) were better recalled, with the latter being stronger at the shorter duration. Only the high sensation-seeking group showed a Blocks effect for lists with an isolated item such that there was a greater number of items correct per list in Block 1 than in Block 2. This finding is consistent with the argument that higher scores on sensation seeking are associated with greater cortical arousal and better memory for newness and change. Students with high sensation-seeking scores showed superior memory for the isolated list when it contained an isolate if allowed more processing time. It is argued that high sensation-seeking scores were associated with more effective transfer of items from shorter to longer-term memory. A rapid nontime-dependent perceptual process was used to explain the isolation effect. The poorer overall list performance for the lists with the isolate was explained in terms of the intense nature of the isolate.

  6. Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis

    PubMed Central

    Atanur, Santosh; Musilová, Alena; Zídek, Václav; Saba, Laura; Warnecke, Andreas; Khademi, Mohsen; Studahl, Marie; Aurelius, Elisabeth; Hjalmarsson, Anders; Garcia-Diaz, Ana; Denis, Cécile V.; Bergström, Tomas; Sköldenberg, Birgit; Kockum, Ingrid; Aitman, Timothy; Hübner, Norbert; Olsson, Tomas; Pravenec, Michal; Diez, Margarita

    2016-01-01

    Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain. Although viral latency in neurons is very common in the population, it remains unclear why certain individuals develop HSE. Here we explore potential host genetic variants predisposing to HSE. In order to investigate this we used a rat HSE model comparing the HSE susceptible SHR (Spontaneously Hypertensive Rats) with the asymptomatic infection of BN (Brown Norway). Notably, both strains have HSV-1 spread to the CNS at four days after infection. A genome wide linkage analysis of 29 infected HXB/BXH RILs (recombinant inbred lines—generated from the prior two strains), displayed variable susceptibility to HSE enabling the definition of a significant QTL (quantitative trait locus) named Hse6 towards the end of chromosome 4 (160.89–174Mb) containing the Vwf (von Willebrand factor) gene. This was the only gene in the QTL with both cis-regulation in the brain and included several non-synonymous SNPs (single nucleotide polymorphism). Intriguingly, in human chromosome 12 several SNPs within the intronic region between exon 43 and 44 of the VWF gene were associated with human HSE pathogenesis. In particular, rs917859 is nominally associated with an odds ratio of 1.5 (95% CI 1.11–2.02; p-value = 0.008) after genotyping in 115 HSE cases and 428 controls. Although there are possibly several genetic and environmental factors involved in development of HSE, our study identifies variants of the VWF gene as candidates for susceptibility in experimental and human HSE. PMID:27224245

  7. Effect of von Willebrand factor on clot structure and lysis.

    PubMed

    Marchi, Rita; Rojas, Héctor

    2015-07-01

    Von Willebrand Factor (vWF) is constitutively secreted by the endothelium and incorporated in the fibrin clots under slow clotting conditions. The aim of the present work was to study the effect of vWF on clot structure and lysis. Purified fibrinogen was mixed with vWF or Tris-buffered saline and clotted with thrombin - activated factor XIII. Fibrin polymerization was followed by turbidity at 350 nm during 2.5 h. After this time, plasmin was added on the top of the clots, and the optical density (OD) was read until baseline values. vWF effect on network[Combining Acute Accent]s porosity was evaluated by permeation using the same clotting conditions as for fibrin polymerization. Clot structure was visualized and analyzed by laser scanning confocal microscopy (LSCM). The rate of fibrin polymerization was 1.47 mOD/s in the presence of vWF and 0.5 mOD/s when vWF was not added (P < 0.05). The fibrin lysis rate was approximately four times faster when vWF was added to fibrinogen. The fibrin network porosity was (20.4 ± 1.6) × 10 cm with vWF and (8.3 ± 1.2) × 10 cm without external vWF (P < 0.05). The analysis of LSCM images showed that vWF increased fibrin fibers diameter and the networks[Combining Acute Accent] pores size. In conclusion, vWF covalently crosslinked to fibrin modify its structure (increases fibrin diameter and the pores filling space of the meshwork) that accelerates the fibrin lysis rate.

  8. Philipp Frank, Richard von Mises, and the Frank-Mises

    NASA Astrophysics Data System (ADS)

    Siegmund-Schultze, Reinhard

    2007-01-01

    The theoretical physicist Philipp Frank (1884 1966) and the applied mathematician Richard von Mises (1883 1953) both received their university education in Vienna shortly after 1900 and became friends at the latest during the Great War.They were attached to the Vienna Circle of Logical Positivists and wrote an influential two-part work on the differential and integral equations of mechanics and physics, the Frank-Mises, of 1925 and 1927, with its second edition following in 1930 and 1935.This work originated in the lectures that the mathematician Bernhard Riemann (1826 1866) delivered on partial differential equations and their applications to physical questions at the University of Göttingen between 1854 and 1862, which were edited and published posthumously in1869 by the physicist Karl Hattendorff (1834 1882).The immediate precursor of the Frank-Mises, however, was the extensive revision of Hattendorff’s edition of Riemann’s lectures that the mathematician Heinrich Weber (1842 1913) published in two volumes, the Riemann-Weber, of 1900 and 1901, with its second edition following in 1910 and 1912. I trace this historical lineage, explore the nature and contents of the Frank-Mises, and discuss its complementary relationship to the first volume of the text that the mathematicians Richard Courant (1888 1972) and David Hilbert (1862 1943) published on the methods of mathematical physics in 1924, the Courant-Hilbert,which, when it and its second volume of 1937 were translated into English and extensively revised in 1953 and 1961, eclipsed the classic Frank-Mises.

  9. Von Willebrand factor in the outcome of temporal arteritis.

    PubMed Central

    Cid, M C; Monteagudo, J; Oristrell, J; Vilaseca, J; Pallarés, L; Cervera, R; Font, C; Font, J; Ingelmo, M; Urbano-Márquez, A

    1996-01-01

    OBJECTIVE: To determine fluctuation in circulating von Willebrand factor (vWF) in the outcome of patients with temporal arteritis. METHODS: Plasma vWF antigen concentrations were measured in 65 patients with biopsy proven temporal arteritis at different disease activity stages, in 12 with isolated polymyalgia rheumatica, and in 16 controls. Fourteen temporal arteritis patients underwent serial determinations during the course of their disease. RESULTS: vWF concentrations were significantly raised in temporal arteritis (mean 220 [arbitrary units], range 96 to 720) and in polymyalgia rheumatica (mean 196, range 103 to 266) compared with healthy controls (mean 98, range 75 to 137) (P < 0.05). Although vWF values tended to be higher in temporal arteritis, no significant differences were found between temporal arteritis and polymyalgia rheumatica patients nor between temporal arteritis patients with ischaemic complications (mean 269, range 130 to 720) and those who presented with polymyalgia rheumatica or constitutional symptoms only (mean 179, range 140 to 220). The highest levels were obtained in patients with associated, mainly infectious, diseases (mean 631, range 240 to 1680). Raised vWF values found in active temporal arteritis patients (mean 220, range 96 to 720) persisted within the first two years after the beginning of treatment (mean 244, range 102 to 510) but tended to normalise in patients in long term remission (mean 143, range 50 to 260). CONCLUSIONS: Persistent elevation of vWF during early remission of temporal arteritis might represent an endothelial activation status induced by a remaining inflammatory microenvironment rather than a marker of endothelial cell injury. In long term remission, decreasing vWF concentrations might reflect progression of inflammatory lesions to a healing stage. PMID:9014589

  10. Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis.

    PubMed

    Abdelmagid, Nada; Bereczky-Veress, Biborka; Atanur, Santosh; Musilová, Alena; Zídek, Václav; Saba, Laura; Warnecke, Andreas; Khademi, Mohsen; Studahl, Marie; Aurelius, Elisabeth; Hjalmarsson, Anders; Garcia-Diaz, Ana; Denis, Cécile V; Bergström, Tomas; Sköldenberg, Birgit; Kockum, Ingrid; Aitman, Timothy; Hübner, Norbert; Olsson, Tomas; Pravenec, Michal; Diez, Margarita

    2016-01-01

    Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain. Although viral latency in neurons is very common in the population, it remains unclear why certain individuals develop HSE. Here we explore potential host genetic variants predisposing to HSE. In order to investigate this we used a rat HSE model comparing the HSE susceptible SHR (Spontaneously Hypertensive Rats) with the asymptomatic infection of BN (Brown Norway). Notably, both strains have HSV-1 spread to the CNS at four days after infection. A genome wide linkage analysis of 29 infected HXB/BXH RILs (recombinant inbred lines-generated from the prior two strains), displayed variable susceptibility to HSE enabling the definition of a significant QTL (quantitative trait locus) named Hse6 towards the end of chromosome 4 (160.89-174Mb) containing the Vwf (von Willebrand factor) gene. This was the only gene in the QTL with both cis-regulation in the brain and included several non-synonymous SNPs (single nucleotide polymorphism). Intriguingly, in human chromosome 12 several SNPs within the intronic region between exon 43 and 44 of the VWF gene were associated with human HSE pathogenesis. In particular, rs917859 is nominally associated with an odds ratio of 1.5 (95% CI 1.11-2.02; p-value = 0.008) after genotyping in 115 HSE cases and 428 controls. Although there are possibly several genetic and environmental factors involved in development of HSE, our study identifies variants of the VWF gene as candidates for susceptibility in experimental and human HSE.

  11. Evaluation of von Willebrand factor in COPD patients*

    PubMed Central

    Bártholo, Thiago Prudente; da Costa, Cláudia Henrique; Rufino, Rogério

    2014-01-01

    OBJECTIVE: To compare the absolute serum von Willebrand factor (vWF) levels and relative serum vWF activity in patients with clinically stable COPD, smokers without airway obstruction, and healthy never-smokers. METHODS: The study included 57 subjects, in three groups: COPD (n = 36); smoker (n = 12); and control (n = 9). During the selection phase, all participants underwent chest X-rays, spirometry, and blood testing. Absolute serum vWF levels and relative serum vWF activity were obtained by turbidimetry and ELISA, respectively. The modified Medical Research Council scale (cut-off score = 2) was used in order to classify COPD patients as symptomatic or mildly symptomatic/asymptomatic. RESULTS: Absolute vWF levels were significantly lower in the control group than in the smoker and COPD groups: 989 ± 436 pg/mL vs. 2,220 ± 746 pg/mL (p < 0.001) and 1,865 ± 592 pg/mL (p < 0.01). Relative serum vWF activity was significantly higher in the COPD group than in the smoker group (136.7 ± 46.0% vs. 92.8 ± 34.0%; p < 0.05), as well as being significantly higher in the symptomatic COPD subgroup than in the mildly symptomatic/asymptomatic COPD subgroup (154 ± 48% vs. 119 ± 8%; p < 0.05). In all three groups, there was a negative correlation between FEV1 (% of predicted) and relative serum vWF activity (r2 = −0.13; p = 0.009). CONCLUSIONS: Our results suggest that increases in vWF levels and activity contribute to the persistence of systemic inflammation, as well as increasing cardiovascular risk, in COPD patients. PMID:25210959

  12. "'And They Lived Happily Ever After": The Fairy Tale of Radical Constructivism and Von Glasersfeld's Ethical Disengagement

    ERIC Educational Resources Information Center

    d'Agnese, Vasco

    2015-01-01

    Is von Glasersfeld's constructivism actually radical? In this article, I respond to this question by analyzing von Glasersfeld's main works. I argue that the essential theoretical move of radical constructivism--namely the assertion that reality is the construction of a human mind that only responds to the subjective perception of "what…

  13. Estimating the probability distribution of von Mises stress for structures undergoing random excitation. Part 1: Derivation

    SciTech Connect

    Segalman, D.; Reese, G.

    1998-09-01

    The von Mises stress is often used as the metric for evaluating design margins, particularly for structures made of ductile materials. For deterministic loads, both static and dynamic, the calculation of von Mises stress is straightforward, as is the resulting calculation of reliability. For loads modeled as random processes, the task is different; the response to such loads is itself a random process and its properties must be determined in terms of those of both the loads and the system. This has been done in the past by Monte Carlo sampling of numerical realizations that reproduce the second order statistics of the problem. Here, the authors present a method that provides analytic expressions for the probability distributions of von Mises stress which can be evaluated efficiently and with good precision numerically. Further, this new approach has the important advantage of providing the asymptotic properties of the probability distribution.

  14. An Alternative to Von Glasersfeld's Subjectivism in Science Education: Deweyan Social Constructivism

    NASA Astrophysics Data System (ADS)

    Garrison, Jim

    An influential view of constructivism in science and mathematics educational research and practice is that of Ernst von Glasersfeld. It is a peculiarly subjectivist form of constructivism that should not be attractive to science and mathematics educators concerned with retaining some sort of realism that leaves room for objectivity. The subjectivist constructivism of von Glasersfeld also becomes entangled in untenable mind/body and subject/object dualisms. Finally, these dualisms are unnecessary for social constructivism. I will provide one example of a social constructivist alternative to social constructivism, that of the pragmatic philosopher John Dewey. In presenting Dewey's position I will appeal to Ockham's razor, that is, the admonition not to multiply entities beyond necessity, to shave off the needless mentalistic and psychic entities that lead von Glasersfeld into his subjectivism and dualism.

  15. [Viktor Borisovich von Gyubbenet--a military physician, a surgeon and a social activist].

    PubMed

    Ishutin, O S

    2015-02-01

    The current article is dedicated to a talented surgeon, an organizer of military health care, an extraordinary personality and a public figure--Doctor of Medicine, a privy councilor Victor Borisovich von Guebbenet. A talent of von Gyubbenea as a doctor-surgeon and an organizer of the surgical help on theater of war was especially brightly shown during two big military conflicts of the beginning of the XX century--the Russo-Japanese War (1904-1905) and the First World War I (1914-1918). In the first case doctor von Gyubbenet, being a surgeon of the 3rd Siberian corps successfully manage the activity of military-medical divisions and establishments of Port Arthur garrison. In the second military conflict Victor Borisovich as a doctor and an organizer headed sanitary part of armies of the Western front and successfully directed a medical support of armies of the front since 1915 and until the end of war. PMID:25920178

  16. The use of recombinant activated factor VII in congenital and acquired von Willebrand disease.

    PubMed

    Franchini, Massimo; Veneri, Dino; Lippi, Giuseppe

    2006-11-01

    Recombinant activated factor VII (NovoSeven), a novel hemostatic agent originally developed for the treatment of bleeding episodes in hemophilia A or B patients with inhibitors, has been recently employed with benefit for the management of hemorrhages in other nonhemophilic congenital and acquired hemostatic abnormalities. This review focuses on the use of this drug in acquired and congenital von Willebrand disease. The analysis of the literature data shows that recombinant activated factor VII is an effective agent for the treatment of refractory bleeding in von Willebrand disease patients and for the treatment or prevention of bleeding in those patients with alloantibodies or autoantibodies against von Willebrand factor. Further studies are needed, however, to assess its safety and to optimize the dosages and regimens of therapy in such patients.

  17. Hemophilia And Von Willebrand Disease In Children: Emergency Department Evaluation And Management.

    PubMed

    Schwartz, Kevin R; Rubinstein, Max

    2015-09-01

    Hemophilia and von Willebrand disease are the most common inherited bleeding disorders encountered in the emergency department. Evidence suggests that the management of bleeding disorders in the emergency department is currently suboptimal, and literature to guide evaluation and management in this setting is limited, though some guidelines do exist. The emergency clinician must have a high index of suspicion for new diagnoses, particularly in young patients with unprovoked bleeding and children with multiple or severe bleeds. The foundation of hemophilia treatment is urgent clotting factor replacement, with replacement goals guided by the presenting complaint. Bleeding in von Willebrand disease may be treated with products containing von Willebrand factor or with desmopressin. This review focuses on the epidemiology, pathophysiology, common presentations, evaluation strategies, and emergency management of these bleeding disorders.

  18. IntegraTUM Teilprojekt E-Mail: Rezentralisierung von E-Mail-Services

    NASA Astrophysics Data System (ADS)

    Diehn, Max; Haarer, Ado; Schreiner, Alexander; Storz, Michael

    Das Teilprojekt E-Mail hatte ursprünglich die Aufgabe einen zentralen Mailservice mit verteilter Administration der Mailadressen für die TUM aufzubauen und diesen durch Anti-Spam- und Anti-Viren-Maßnahmen zu schützen. Auf diesen Mailservice sollten sowohl die am LRZ gehosteten Maildomains als auch die vielen lokal betriebenen Mailserver - soweit von deren Betreibern gewünscht - migriert werden. Neben einigen Rückschlägen und Hindernissen kam es im Laufe des Projektes auch zu einer Änderung der Anforderungen, sodass zum Ende des Projektes statt eines reinen Mailsystems ein Doppelsystem mit "shared SMTP address space" bestehend aus einem klassischen Message-Store mit POP/IMAP-Zugriff auf Basis von Postfix + Dovecot und einem Groupware-System auf Basis von Microsoft Exchange in Produktion ging, wobei jeder Mitarbeiter und Student der TUM wählen kann, auf welchem der beiden Systeme sich seine Mailbox befindet.

  19. Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test.

    PubMed

    Young, E E; Bryant, C D; Lee, S E; Peng, X; Cook, B; Nair, H K; Dreher, K J; Zhang, X; Palmer, A A; Chung, J M; Mogil, J S; Chesler, E J; Lariviere, W R

    2016-07-01

    Mechanical sensitivity is commonly affected in chronic pain and other neurological disorders. To discover mechanisms of individual differences in punctate mechanosensation, we performed quantitative trait locus (QTL) mapping of the response to von Frey monofilament stimulation in BXD recombinant inbred (BXD) mice. Significant loci were detected on mouse chromosome (Chr) 5 and 15, indicating the location of underlying polymorphisms that cause heritable variation in von Frey response. Convergent evidence from public gene expression data implicates candidate genes within the loci: von Frey thresholds were strongly correlated with baseline expression of Cacna2d1, Ift27 and Csnk1e in multiple brain regions of BXD strains. Systemic gabapentin and PF-670462, which target the protein products of Cacna2d1 and Csnk1e, respectively, significantly increased von Frey thresholds in a genotype-dependent manner in progenitors and BXD strains. Real-time polymerase chain reaction confirmed differential expression of Cacna2d1 and Csnk1e in multiple brain regions in progenitors and showed differential expression of Cacna2d1 and Csnk1e in the dorsal root ganglia of the progenitors and BXD strains grouped by QTL genotype. Thus, linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 and Csnk1e may contribute to individual differences in von Frey filament response. This study implicates Cacna2d1 and Ift27 in basal mechanosensation in line with their previously suspected role in mechanical hypersensitivity. Csnk1e is implicated for von Frey response for the first time. Further investigation is warranted to identify the specific polymorphisms involved and assess the relevance of these findings to clinical conditions of disturbed mechanosensation. PMID:27231153

  20. (Never) Mind your p's and q's: Von Neumann versus Jordan on the foundations of quantum theory

    NASA Astrophysics Data System (ADS)

    Duncan, A.; Janssen, M.

    2013-03-01

    In 1927, in two papers entitled "On a new foundation [Neue Begründung] of quantum mechanics," Pascual Jordan presented his version of what came to be known as the Dirac-Jordan statistical transformation theory. Jordan and Paul Dirac arrived at essentially the same theory independently of one another at around the same time. Later in 1927, partly in response to Jordan and Dirac and avoiding the mathematical difficulties facing their approach, John von Neumann developed the modern Hilbert space formalism of quantum mechanics. We focus on Jordan and von Neumann. Central to the formalisms of both are expressions for conditional probabilities of finding some value for one quantity given the value of another. Beyond that Jordan and von Neumann had very different views about the appropriate formulation of problems in quantum mechanics. For Jordan, unable to let go of the analogy to classical mechanics, the solution of such problems required the identification of sets of canonically conjugate variables, i.e., p's and q's. For von Neumann, not constrained by the analogy to classical mechanics, it required only the identification of a maximal set of commuting operators with simultaneous eigenstates. He had no need for p's and q's. Jordan and von Neumann also stated the characteristic new rules for probabilities in quantum mechanics somewhat differently. Jordan and Dirac were the first to state those rules in full generality. Von Neumann rephrased them and, in a paper published a few months later, sought to derive them from more basic considerations. In this paper we reconstruct the central arguments of these 1927 papers by Jordan and von Neumann and of a paper on Jordan's approach by Hilbert, von Neumann, and Nordheim. We highlight those elements in these papers that bring out the gradual loosening of the ties between the new quantum formalism and classical mechanics. This paper was written as part of a joint project in the history of quantum physics of the Max Planck

  1. Von Donuts und Zucker: Mit Neutronen biologische Makromoleküle erforschen

    NASA Astrophysics Data System (ADS)

    May, Roland P.

    2003-05-01

    Für die Erforschung von Biomolekülen bieten Neutronen einzigartige Eigenschaften. Vor allem ihre unterschiedliche Wechselwirkung mit dem natürlichen Wasserstoff und seinem schweren Isotop Deuterium ermöglicht tiefe Einblicke in Struktur, Funktion und Dynamik von Proteinen, Nukleinsäuren und Biomembranen. Bei vielen Fragestellungen zur Strukturaufklärung gibt es kaum oder keine Alternative zum Neutron. Das Institut Laue-Langevin trägt Bahnbrechendes zum Erfolg der Neutronen-Methoden in der Biologie bei.

  2. On the history of Ludwig von Bertalanffy's "general systemology", and on its relationship to cybernetics - Part II: Contexts and developments of the systemological hermeneutics instigated by von Bertalanffy

    NASA Astrophysics Data System (ADS)

    Pouvreau, David

    2014-02-01

    The history of "general system theory" is investigated in order to clarify its meanings, vocations, foundations and achievements. It is characterized as the project of a science of the systemic interpretation of the "real", renamed here "general systemology". The contexts and modes of its elaboration, publication and implementation are discussed. The paper mostly focuses on the works of its instigator: Ludwig von Bertalanffy. However, general systemology was a collective project: the main contributions of other "systemologists", from the 1950s until the 1970s, are hence also considered. Its solidarity with the history of the Society for General Systems Research is notably discussed. A reconstruction of the systemological hermeneutics is undertaken on this basis. It finds out the potential systematic unity underlying the diversity of the contributions to this both scientific and philosophical project. Light is thus shed on the actual scope of von Bertalanffy's works.

  3. Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A

    PubMed Central

    Castaman, Giancarlo; Linari, Silvia

    2016-01-01

    Several plasma-derived intermediate and high-purity concentrates containing von Willebrand factor (VWF) and factor VIII (FVIII) are currently available. The main role of these products in the management of the pediatric population is represented by the replacement therapy in patients with severe or intermediate forms of von Willebrand disease, in whom other treatments are ineffective or contraindicated. Another important role of VWF/FVIII concentrates in children may be their use in immune tolerance induction (ITI) protocols. ITI is particularly recommended for hemophilia A children who have developed an inhibitor against FVIII, currently the most serious complication of substitutive treatment in hemophilia. Although recombinant concentrates may represent the preferred option in children with hemophilia A, VWF/FVIII concentrates may offer an advantage in rescuing patients who failed previous ITI. PMID:27445481

  4. Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A.

    PubMed

    Castaman, Giancarlo; Linari, Silvia

    2016-01-01

    Several plasma-derived intermediate and high-purity concentrates containing von Willebrand factor (VWF) and factor VIII (FVIII) are currently available. The main role of these products in the management of the pediatric population is represented by the replacement therapy in patients with severe or intermediate forms of von Willebrand disease, in whom other treatments are ineffective or contraindicated. Another important role of VWF/FVIII concentrates in children may be their use in immune tolerance induction (ITI) protocols. ITI is particularly recommended for hemophilia A children who have developed an inhibitor against FVIII, currently the most serious complication of substitutive treatment in hemophilia. Although recombinant concentrates may represent the preferred option in children with hemophilia A, VWF/FVIII concentrates may offer an advantage in rescuing patients who failed previous ITI. PMID:27445481

  5. Platelet deposition on von Willebrand factor-deficient vessels. Extracorporeal perfusion studies in swine with von Willebrand's disease using native and heparinized blood.

    PubMed

    Badimon, L; Badimon, J J; Rand, J; Turitto, V T; Fuster, V

    1987-11-01

    Native (nonanticoagulated) and heparinized blood from both normal swine and swine with von Willebrand's disease was exposed to de-endothelialized thoracic aorta from normal pigs under controlled flow conditions. We have shown that these normal de-endothelialized vessel segments do not contain von Willebrand factor (vWF) in the subendothelial surface; thus, the vascular model that we are using here is representative of the conditions in severe von Willebrand's disease. The blood was recirculated for selected periods of time through an extracorporeal circuit (carotid-jugular shunt), containing a tubular perfusion chamber that held the vessel segment. Flow rates and chamber diameters were selected such that the wall shear rates at the vascular segment were 212 to 3380 sec-1. Platelets were labeled with indium 111 and their total deposition determined by a gamma counter; selected areas were also observed by electron microscopy. When native blood was perfused, the deposition of platelets depended on platelet-plasma vWF only at high wall shear rates (1690 sec-1 or greater) typical of the microcirculation, but not at the lower shear rates (212 and 424 sec-1), more characteristic of the larger arteries and veins. In contrast, when heparinized blood was perfused, platelet deposition on the vascular segments depended on the presence of vWF over the entire range of shear conditions studied. These findings demonstrate in an extracorporeal perfusion system that the defect in platelet-vessel wall interaction in swine with von Willebrand's disease is influenced by both the local flow conditions and the level of activation of the coagulation system. In the presence of an intact coagulation system a synergistic interaction between procoagulant moieties and vWF was observed at high shear rates.

  6. "The captain and canon" C. W. A. von Wahl (1760-1846) (German Title: "Der Hauptmann und Kanonikus" C. W. A. von Wahl (1760-1846) )

    NASA Astrophysics Data System (ADS)

    Brosche, Peter

    Von Wahl was an active member of the group of independent scholars, who were working in the German states within Goethe's time, and who performed astrometric and geodetic observations and calculations. Here we present some cornerstones of his life; longer intervals of it took place in Allstedt south of the Harz and in Halberstadt. Small scientific assets have been preserved at the Universitäts-Sternwarte Bonn. Therein, a lecture on secular variations of the ecliptic is of singular nature.

  7. Function of von Willebrand factor after crossed bone marrow transplantation between normal and von Willebrand disease pigs: effect on arterial thrombosis in chimeras.

    PubMed Central

    Nichols, T C; Samama, C M; Bellinger, D A; Roussi, J; Reddick, R L; Bonneau, M; Read, M S; Bailliart, O; Koch, G G; Vaiman, M

    1995-01-01

    von Willebrand factor (vWF) is essential for the induction of occlusive thrombosis in stenosed and injured pig arteries and for normal hemostasis. To separate the relative contribution of plasma and platelet vWF to arterial thrombosis, we produced chimeric normal and von Willebrand disease pigs by crossed bone marrow transplantation; von Willebrand disease (vWD) pigs were engrafted with normal pig bone marrow and normal pigs were engrafted with vWD bone marrow. Thrombosis developed in the chimeric normal pigs that showed normal levels of plasma vWF and an absence of platelet vWF; but no thrombosis occurred in the chimeric vWD pigs that demonstrated normal platelet vWF and an absence of plasma vWF. The ear bleeding times of the chimeric pigs were partially corrected by endogenous plasma vWF but not by platelet vWF. Our animal model demonstrated that vWF in the plasma compartment is essential for the development of arterial thrombosis and that it also contributes to the maintenance of bleeding time and hemostasis. Images Fig. 2 Fig. 3 PMID:7708664

  8. BOOK REVIEW: Meilensteine der Astronomie - Von Aristoteles bis Hawking

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Hamel, J.

    2006-12-01

    A writer, more specific a writer on the history of astronomy, might from time to time look at the collected document folders with all the research material and reprints, and might wonder: has this been all? Especially at a time when recycling is in vogue? And, perhaps with a request or an invitation to submit something, he or she might consider re-using the material before its definitive disposal. Well, such are my feelings when I looked at Jurgen Hamel's new book Milestones of Astronomy - From Aristoteles to Hawking . A slight chance for survival of medium-sized publishers like Kosmos is to offer popular books, and a title must attract potential buyers: Aristoteles means the "old" times, and as concerns the "mad scientist" of modern times, Stephen Hawking has by now dethroned Einstein. In 1998, Hamel had published a Geschichte der Astronomie - Von den Anfangen bis zur Gegenwart (History of astronomy, from the beginnings to the present), which, of course, he could not simply copy. This time, he selected some stones from his research areas - milestones, touchstones, stumbling blocks in the long road of astronomical evolution - and put them between the covers of his new book. So let us look at these (mile)stones . The reader is informed about Aristoteles on 2 pages, but his medieval interpreter Johannes de Sacrobosco gets 8 pages! Copernicus' life and achievements are described on 9 pages, closely followed by his devotee and translator Rothmann with 8 pages; Copernicus' contemporary, Peter Apian, however, gets about 13! Bessel's and Herschel's lifes and works are described on well-deserved 13 and 15 pages, while the achievements of the two Lucasian professors, Isaac Newton and Stephen Hawking, are just outlined in a single paragraph! Thus, importance is sometimes inversely proportional to text length... But let us become serious now. Why should an active historian outline, for the hundreth time, the life of Copernicus, while there are so many interesting, and often

  9. Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions

    NASA Astrophysics Data System (ADS)

    Cheng, Szu-Cheng; Jheng, Shih-Da

    2016-08-01

    This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions.

  10. [Correspondence between Winkler and Von Monakow. 2. Developments in psychiatry and neurology (1900-1930)].

    PubMed

    Koehler, P J; Jagella, C

    2001-12-22

    In this second article Winkler's and Von Monakow's views on the evolution of psychiatry and neurology (1900-1930) are described. They discussed a number of scientific subjects in their correspondence, such as the localisation of functions in the central nervous system and in particular Von Monakow's concept of 'diaschisis'. This concept explained the phenomenon that symptoms during the acute phase of central nervous system disorders are more extensive and of a different nature than those during the chronic phase. The controversy between the neuron theory and the reticular theory was also discussed in the correspondence. One of the reasons for the correspondence and meetings was the plan to compile an atlas of the brain although due to the outbreak of World War I this did not come to fruition. Finally there was an extensive correspondence concerning the psychoanalytic movement within the psychiatry, of which Winkler and Von Monakow, as biologically orientated neuropsychiatrists, were highly critical. German language neuropsychiatry has had a considerable influence in the Netherlands and this is in part due to the relationship Winkler had with German neuropsychiatrists and Von Monakow in particular.

  11. Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions

    PubMed Central

    Cheng, Szu-Cheng; Jheng, Shih-Da

    2016-01-01

    This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions. PMID:27545446

  12. Dr. Wernher Von Braun greeting dignitaries at the Redstone Arsenal airfield.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George E. Mueller, center, associate administrator for manned space flight, is flanked by Dr. Wernher Von Braun, left, and Dr. Eberhard Rees at the Redstone Arsenal airstrip. the associate adminstrator was making his annual staff visit to the Marshall Space Flight Center.

  13. Dr. Wernher Von Braun on Tour With U.S. congressman Armistead Seldon

    NASA Technical Reports Server (NTRS)

    1999-01-01

    U.S. representative Armistead Seldon (D.-Al) tries on an astronaut maneuvering unit mockup during a tour of the Saturn I workshop at the Marshall Space Flight center. Explaining the unit and the workshop to Representative Seldon is Dr. Wernher Von Braun, director of the Marshall Center.

  14. Dr. Wernher Von Braun at the Marshall Space Flight Center's neutral buoyancy simulator.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, Marshall Space Flight Center director, points and asks a question about the operation of the center's neutral buoyancy facility in the Manufacturing Engineering Laboratory. The facility was used to test and evaluate hardware and operations hat were planned for Apollo applications program flights.

  15. The signalling contributions of Constantin von Economo to basic, clinical and evolutionary neuroscience.

    PubMed

    Triarhou, Lazaros C

    2006-04-14

    The study, and the companion article that follows, reviews the entire spectrum of the epoch-making contributions of Constantin von Economo (1876-1931) to basic, clinical and evolutionary Neuroscience. An astute observer and avid writer, von Economo left marks of brilliance on fundamental areas of brain research through an exuberant record of publications dating from 1899 to 1932. His ingenious medical career began with the histological study of the developing pigeon and chick hypophysis, and culminated with bold propositions about the neuroanatomy of talent and the future evolution of the human brain. On the way, he made the seminal discovery of encephalitis lethargica ('von Economo disease'), and produced, with Georg N. Koskinas (1885-1975), one of the masterpieces of brain science, the 1925 Cytoarchitectonics of the Adult Human Cerebral Cortex, defining 107 cortical areas on the basis of cytoarchitectonic criteria. His untimely death at age 55, barely 5.5 months after inaugurating his new Brain Research Institute in Vienna, deprived the Neuroscience world of one of its brightest protagonists during the 20th century. An annotated total of 139 scientific works by von Economo have been identified. The present study covers the 76 works on brain structure, evolution and intelligence, and general works on nervous and mental pathology, with the complete bibliographic information. The companion article covers the remaining 63 works on encephalitis lethargica and sleep regulation.

  16. Zuverlässigkeit digitaler Schaltungen unter Einfluss von intrinsischem Rauschen

    NASA Astrophysics Data System (ADS)

    Kleeberger, V. B.; Schlichtmann, U.

    2011-08-01

    Die kontinuierlich fortschreitende Miniaturisierung in integrierten Schaltungen führt zu einem Anstieg des intrinsischen Rauschens. Um den Einfluss von intrinsischem Rauschen auf die Zuverlässigkeit zukünftiger digitaler Schaltungen analysieren zu können, werden Methoden benötigt, die auf CAD-Verfahren wie Analogsimulation statt auf abschätzenden Berechnungen beruhen. Dieser Beitrag stellt eine neue Methode vor, die den Einfluss von intrinsischem Rauschen in digitalen Schaltungen für eine gegebene Prozesstechnologie analysieren kann. Die Amplituden von thermischen, 1/f und Schrotrauschen werden mit Hilfe eines SPICE Simulators bestimmt. Anschließend wird der Einfluss des Rauschens auf die Schaltungszuverlässigkeit durch Simulation analysiert. Zusätzlich zur Analyse werden Möglichkeiten aufgezeigt, wie die durch Rauschen hervorgerufenen Effekte im Schaltungsentwurf mit berücksichtigt werden können. Im Gegensatz zum Stand der Technik kann die vorgestellte Methode auf beliebige Logikimplementierungen und Prozesstechnologien angewendet werden. Zusätzlich wird gezeigt, dass bisherige Ansätze den Einfluss von Rauschen bis um das Vierfache überschätzen.

  17. Displacements Of Brownian Particles In Terms Of Marian Von Smoluchowski's Heuristic Model

    ERIC Educational Resources Information Center

    Klein, Hermann; Woermann, Dietrich

    2005-01-01

    Albert Einstein's theory of the Brownian motion, Marian von Smoluchowski's heuristic model, and Perrin's experimental results helped to bring the concept of molecules from a state of being a useful hypothesis in chemistry to objects existing in reality. Central to the theory of Brownian motion is the relation between mean particle displacement and…

  18. Space: The Long-Range Future: An Interview with Jesco von Puttkamer.

    ERIC Educational Resources Information Center

    Lawler, Andrew

    1985-01-01

    Jesco von Puttkamer manages long-range planning in NASA's Office of Space Flight. He believes that space offers the opportunity to ease global tensions, help the developing world, and create a new global culture off the planet. (Author/RM)

  19. Citizenship Ceremony for Dr. von Braun and German-Born Scientists and Engineers

    NASA Technical Reports Server (NTRS)

    1955-01-01

    In a swearing-in ceremony held at Huntsville High School, one hundred and three German-born scientists and engineers, along with family members, took the oath of citizenship to become United States citizens. Among those taking the oath was Dr. Wernher von Braun, located in the second row, right side, third from the end.

  20. Dr. Wernher von Braun and Dr. Ernst Stuhlinger Sign Citizenship Certificates

    NASA Technical Reports Server (NTRS)

    1955-01-01

    The members of the Peenemuende team and their family members were awarded the United States citizenship on April 14, 1955. Pictured here is Dr. Ernst Stuhlinger (middle) and Dr. Wernher von Braun signing U.S. citizenship certificates. Martin Schilling is at left.

  1. Untersuchung der Störwirkung von LTE auf SRD Anwendungen bei 868 MHz

    NASA Astrophysics Data System (ADS)

    Welpot, M.; Wunderlich, S.; Gaspard, I.

    2014-11-01

    Moderne Hausautomatisierungssysteme, Alarmanlagen oder auch Funk-Zugangssysteme in Haus und Automobil setzen auf frei nutzbare Frequenzen in ISM/SRD-Bändern. Die rasante Zunahme an privaten und kommerziell genutzten Applikationen im SRD-Band bei 868 MHz und der Ausbau der LTE-Mobilfunknetze im Frequenzbereich unterhalb von 1 GHz ("Digital Dividend") wirft zunehmend die Frage nach der Funkverträglichkeit dieser Systeme untereinander auf. Während die SRD-Funkmodule auf eine geringe Sendeleistung von ~ +14 dBm beschränkt sind (Ralf and Thomas, 2009), beträgt die maximale LTE-Sendeleistung im Uplink nach (ETSI-Norm, 2011) +23 dBm. Zusammen mit der Einführung von LTE im Frequenzbereich unterhalb 1 GHz als DSL-Ersatz vor allem in ländlichen Gebieten, ergibt sich damit als mögliches Störszenario, dass durch die Aussendung des LTE-Endgerätes im Bereich von ca. 850 MHz die SRD-Funkverbindungen bei 868 MHz insbesondere dann gestört werden, wenn die Antennen beider Funksysteme räumlich nahe zueinander angeordnet sind und folglich nur eine geringe zusätzliche Entkopplung der Systeme bieten. In der vorliegenden Arbeit wird das LTE-Störpotential auf SRD-Empfänger praxisnah untersucht.

  2. Beyond victimhood. The struggle of Munich anatomist Titus von Lanz during National Socialism.

    PubMed

    Schütz, Mathias; Waschke, Jens; Marckmann, Georg; Steger, Florian

    2015-09-01

    The article analyzes the life and career of the anatomist Titus von Lanz (1897-1967) of Munich focusing on the period of National Socialism (NS). Von Lanz lost his position as an associate professor at the Anatomical Institute of Munich University because of his marriage to a "half-Jewish" woman in 1938. In contrast to most of his colleagues affected by National Socialist measures, von Lanz had opportunities to save his career and made extensive use of them. His story is that of a complicated struggle for the continuation of his work, involving a wide range of supporters from prestigious physicians to high-ranking National Socialist officials as well as the alienation of his colleagues at the Munich department of anatomy. The article tries to clarify these developments through the presentation of his social background, his supporters, his enemies, the research he conducted during NS and von Lanz' own remembrance of these developments from the post-war period. It aims at laying out a critical appreciation of his motives and actions, thereby contributing to the understanding of individual behavior of anatomists under NS.

  3. Identifikationsverfahren zur Analyse von EEG-Signalen bei Epilepsie mit Reaktions-Diffusions Netzwerken

    NASA Astrophysics Data System (ADS)

    Gollas, F.; Tetzlaff, R.

    2007-06-01

    Partielle Differentialgleichungen des Reaktions-Diffusions-Typs beschreiben Phänomene wie Musterbildung, nichtlineare Wellenausbreitung und deterministisches Chaos und werden oft zur Untersuchung komplexer Vorgänge auf den Gebieten der Biologie, Chemie und Physik herangezogen. Zellulare Nichtlineare Netzwerke (CNN) sind eine räumliche Anordnung vergleichsweise einfacher dynamischer Systeme, die eine lokale Kopplung untereinander aufweisen. Durch eine Diskretisierung der Ortsvariablen können Reaktions-Diffusions-Gleichungen häufig auf CNN mit nichtlinearen Gewichtsfunktionen abgebildet werden. Die resultierenden Reaktions-Diffusions-CNN (RD-CNN) weisen dann in ihrer Dynamik näherungsweise gleiches Verhalten wie die zugrunde gelegten Reaktions-Diffusions-Systeme auf. Werden RD-CNN zur Identifikation neuronaler Strukturen anhand von EEG-Signalen herangezogen, so besteht die Möglichkeit festzustellen, ob das gefundene Netzwerk lokale Aktivität aufweist. Die von Chua eingeführte Theorie der lokalen Aktivität Chua (1998); Dogaru und Chua (1998) liefert eine notwendige Bedingung für das Auftreten von emergentem Verhalten in zellularen Netzwerken. Änderungen in den Parametern bestimmter RD-CNN könnten auf bevorstehende epileptische Anfälle hinweisen. In diesem Beitrag steht die Identifikation neuronaler Strukturen anhand von EEG-Signalen durch Reaktions-Diffusions-Netzwerke im Vordergrund der dargestellten Untersuchungen. In der Ergebnisdiskussion wird insbesondere auch die Frage nach einer geeigneten Netzwerkstruktur mit minimaler Komplexität behandelt.

  4. On the Relation of Von Mises Equation with Acoustic Black Holes

    NASA Astrophysics Data System (ADS)

    Cherubini, Christian; Filippi, Simonetta

    2015-01-01

    In this article a discussion of Analogue Gravity is presented in relation with its recently discovered relation, valid at any perturbative order, with the nonlinear Von Mises wave equation of fluid dynamics. A discussion of the role of the acoustic metric at nonlinear level is presented.

  5. Wilhelm von Humboldt and the "Orient": On Edward W. Said's Remarks on Humboldt's Orientalist Studies

    ERIC Educational Resources Information Center

    Messling, Markus

    2008-01-01

    From an epistemological perspective, Wilhelm von Humboldt's studies on the Oriental and East Asian languages and writing systems (Egyptian hieroglyphs, Sanskrit, Chinese, Polynesian) raise the question of his position in the Orientalist discourse of his time. Said [Said, E.W., 1978. "Orientalism. Western Conceptions of the Orient, fourth ed."…

  6. Theoretical justification of the von Weimarn law under homogeneous condensation in the free-molecular regime

    NASA Astrophysics Data System (ADS)

    Kurasov, V. B.

    2016-08-01

    The von Weimarn (Weymarn) law establishes the power dependence for the radius of formed droplets on vapor supersaturation initially created in the system. A theoretical derivation of this law is presented based on the classical Volmer-Becker-Döring-Zel'dovich-Frenkel approach. Analytical expressions have been obtained for all coefficients in this law.

  7. Charles Darwin and other great men in correspondence with Carl Wilhelm von Naegeli.

    PubMed

    Naegeli, W; Wiedemann, H R

    1993-04-15

    The great Swiss-German botanist Carl Wilhelm von Naegeli (1817-1891) was a student of Lorenz Oken, A.P. de Candolle, and Matthias Jacob Schleiden and became a key figure in "genetic" (i.e., evolutionary-developmental) biology in the mid-late 19th century. He was an expert on the hawk-weed, Hieracium and also made important contributions to microbiology. One of his many outstanding students was Carl Correns, one of the 3 rediscoverers of Mendel's work. Naegeli was an early proponent and defender of Darwin. The correspondence preserved in the Naegeli family contains many important letters between Naegeli and his contemporaries. Those from Mendel to Naegeli have passed out of the Naegeli family and were published by Correns earlier in the century. However, exceptionally notable items still in the archives of the Naegeli family include 4 surviving letters from Darwin, 2 letters from Virchow, and 10 from Justus von Liebig. In spite of a lack of appreciation of Mendel's work, we call attention to the importance of those surviving documents from an era in which very few of the greatest naturalists and founders of modern biology--including Goethe, Darwin, Galton, Agassiz, von Humboldt, von Baer--were without "blind spots."

  8. A newborn with very rare von Voss-Cherstvoy syndrome: a case report

    PubMed Central

    Sharma, Deepak; Gupta, Basudev; Shastri, Sweta; Sharma, Pradeep

    2016-01-01

    Introduction von Voss-Cherstvoy syndrome is a part of a group of syndromes with radial and hematologic abnormalities, and until now approximately ten cases have been reported in the literature. This syndrome is characterized by a triad of radial ray defects, occipital encephalocele, and urogenital abnormalities. Case presentation We report a neonate from Indian ethnicity who was diagnosed with von Voss-Cherstvoy syndrome. The neonate had radial ray defect, occipital encephalocele, tetralogy of Fallot, and bilateral agenesis of kidney, ureter, and bladder. The neonate was suspected to have von Voss-Cherstvoy syndrome on the basis of clinical features, which was further confirmed by fibroblast analysis showing somatic mosaicism for del(13q). Conclusion von Voss-Cherstvoy syndrome is a very rare syndrome that can be suspected on the basis of typical clinical features and confirmed by fibroblast analysis showing somatic mosaicism for del(13q). This adds a second case of this chromosome anomaly described in this syndrome. PMID:27499650

  9. Beyond victimhood. The struggle of Munich anatomist Titus von Lanz during National Socialism.

    PubMed

    Schütz, Mathias; Waschke, Jens; Marckmann, Georg; Steger, Florian

    2015-09-01

    The article analyzes the life and career of the anatomist Titus von Lanz (1897-1967) of Munich focusing on the period of National Socialism (NS). Von Lanz lost his position as an associate professor at the Anatomical Institute of Munich University because of his marriage to a "half-Jewish" woman in 1938. In contrast to most of his colleagues affected by National Socialist measures, von Lanz had opportunities to save his career and made extensive use of them. His story is that of a complicated struggle for the continuation of his work, involving a wide range of supporters from prestigious physicians to high-ranking National Socialist officials as well as the alienation of his colleagues at the Munich department of anatomy. The article tries to clarify these developments through the presentation of his social background, his supporters, his enemies, the research he conducted during NS and von Lanz' own remembrance of these developments from the post-war period. It aims at laying out a critical appreciation of his motives and actions, thereby contributing to the understanding of individual behavior of anatomists under NS. PMID:26208340

  10. Einheit von Forschung und Lehre: Implications for State Funding of Universities

    ERIC Educational Resources Information Center

    Frolich, Nicoline; Coate, Kelly; Mignot-Gerard, Stephanie; Knill, Christoph

    2010-01-01

    The Humboldtian educational ideal is based on the idea of the unity of teaching and research in universities ("Einheit von Forschung und Lehre"). The role of the state, according to Humboldt, was to fund universities in such a way that their autonomy was maintained. Much has changed in the funding mechanisms of higher education systems since the…

  11. Charles Darwin and other great men in correspondence with Carl Wilhelm von Naegeli.

    PubMed

    Naegeli, W; Wiedemann, H R

    1993-04-15

    The great Swiss-German botanist Carl Wilhelm von Naegeli (1817-1891) was a student of Lorenz Oken, A.P. de Candolle, and Matthias Jacob Schleiden and became a key figure in "genetic" (i.e., evolutionary-developmental) biology in the mid-late 19th century. He was an expert on the hawk-weed, Hieracium and also made important contributions to microbiology. One of his many outstanding students was Carl Correns, one of the 3 rediscoverers of Mendel's work. Naegeli was an early proponent and defender of Darwin. The correspondence preserved in the Naegeli family contains many important letters between Naegeli and his contemporaries. Those from Mendel to Naegeli have passed out of the Naegeli family and were published by Correns earlier in the century. However, exceptionally notable items still in the archives of the Naegeli family include 4 surviving letters from Darwin, 2 letters from Virchow, and 10 from Justus von Liebig. In spite of a lack of appreciation of Mendel's work, we call attention to the importance of those surviving documents from an era in which very few of the greatest naturalists and founders of modern biology--including Goethe, Darwin, Galton, Agassiz, von Humboldt, von Baer--were without "blind spots." PMID:8484417

  12. Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions.

    PubMed

    Cheng, Szu-Cheng; Jheng, Shih-Da

    2016-01-01

    This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions. PMID:27545446

  13. Einstellung und Wissen von Lehramtsstudierenden zur Evolution - ein Vergleich zwischen Deutschland und der Türkei

    NASA Astrophysics Data System (ADS)

    Graf, Dittmar; Soran, Haluk

    Es wird eine Untersuchung vorgestellt, in der Wissen und Überzeugungen von Lehramtsstudierenden aller Fächer zum Thema Evolution an zwei Universitäten in Deutschland und der Türkei erhoben worden sind. Die Befragung wurde in Dortmund und in Ankara durchgeführt. Es stellte sich heraus, dass ausgeprägte Defizite im Verständnis der Evolutionsmechanismen herrschen. Viele Studierende, insbesondere aus der Türkei, sind nicht von der Faktizität der Evolution überzeugt. Dies gilt sowohl für Studierende mit Fach Biologie als auch für Studierende mit anderen Fächern. Näher untersucht worden sind die Faktoren, die die Überzeugungen zur Evolution beeinflussen können, was ja in Anbetracht der hohen Ablehnungsrate der Evolution von besonderem Interesse ist. Das Vertrauen in die Wissenschaft spielt hierbei eine besondere Rolle: Wer der Wissenschaft vertraut, ist auch eher von der Evolution überzeugt, als diejenigen, die skeptisch gegenüber der Wissenschaft sind.

  14. Perfecting the Individual: Wilhelm von Humboldt's Concept of Anthropology, "Bildung" and Mimesis

    ERIC Educational Resources Information Center

    Wulf, Christoph

    2003-01-01

    In the works of Wilhelm von Humboldt education took on a new quality, focusing firmly on the importance of the individual. "Bildung" was to become the principal task with a view to preparing the individual for the requirements of future life. In this article, the author investigates two aspects relating to the "Bildung" of the individual. First,…

  15. The natural history of occult or angiodysplastic gastrointestinal bleeding in von Willebrand disease.

    PubMed

    Makris, M; Federici, A B; Mannucci, P M; Bolton-Maggs, P H B; Yee, T T; Abshire, T; Berntorp, E

    2015-05-01

    Recurrent gastrointestinal bleeding is one of the most challenging complications encountered in the management of patients with von Willebrand disease (VWD). The commonest cause is angiodysplasia, but often no cause is identified due to the difficulty in making the diagnosis. The optimal treatment to prevent recurrences remains unknown. We performed a retrospective study of VWD patients with occult or angiodysplastic bleeding within the setting of the von Willebrand Disease Prophylaxis Network (VWD PN) to describe diagnostic and treatment strategies. Centres participating in the VWD PN recruited subjects under their care with a history of congenital VWD and gastrointestinal (GI) bleeding due to angiodysplasia, or cases in which the cause was not identified despite investigation. Patients with acquired von Willebrand syndrome or those for whom the GI bleeding was due to another cause were excluded. Forty-eight patients from 18 centres in 10 countries were recruited. Seven individuals had a family history of GI bleeding and all VWD types except 2N were represented. Angiodysplasia was confirmed in 38%, with video capsule endoscopy and GI tract endoscopies being the most common methods of making the diagnosis. Recurrent GI bleeding in VWD is associated with significant morbidity and required hospital admission on up to 30 occasions. Patients were treated with multiple pharmacological agents with prophylactic von Willebrand factor concentrate being the most efficient in preventing recurrence of the GI bleeding. The diagnosis and treatment of recurrent GI bleeding in congenital VWD remains challenging and is associated with significant morbidity. Prophylactic treatment with von Willebrand factor concentrate was the most effective method of preventing recurrent bleeding but its efficacy remains to be confirmed in a prospective study.

  16. [Richard von Volkmann and the Surgical School of Halle in 1867 to 1889].

    PubMed

    Hach, W; Hach, V

    2001-10-01

    Richard von Volkmann (1830-1889) was appointed senior consultant of the University Surgical Hospital in Halle at the young age of 36. On returning home from the war of 1870/1871, he saw traumatic fever rampant in his hospital. He became a rigorous advocate of Lister's method of antisepsis. There were a large number of very serious accidents in the up-coming industrial town of Halle. Acute and chronic inflammation of the joint led to severe disfigurements. By invention of large reconstructive operations von Volkmann was able to obtain impressive results. He was the founder of traumatology and orthopaedic surgery. Tuberculosis was regarded at that time as the most common cause of death. By means of surgery certain forms of the illness could be cured. Tuberculous coxitis and gonarthritis were the most common indications for orthopaedic surgery. Von Volkmann used his distraction method for tuberculous spondylitis.Many terms used in medical practice derive from Richard von Volkmann. He described Volkmann's triangle, ischaemic muscle contractures and resorption fever. He developed a whole range of new methods of surgical procedures and the concept of wound drainage. His name is associated with Volkmann's splint, Volkmann's "sharp spoon" and several other inventions. Richard von Volkmann was one of the founders of the Deutsche Gesellschaft für Chirurgie (German Surgical Society). His famous Träumereien an französischen Kaminen ("Reveries at French Firesides"), an anthology of fairy-tales for his children, played an important role in his life's work. PMID:11727197

  17. The natural history of occult or angiodysplastic gastrointestinal bleeding in von Willebrand disease.

    PubMed

    Makris, M; Federici, A B; Mannucci, P M; Bolton-Maggs, P H B; Yee, T T; Abshire, T; Berntorp, E

    2015-05-01

    Recurrent gastrointestinal bleeding is one of the most challenging complications encountered in the management of patients with von Willebrand disease (VWD). The commonest cause is angiodysplasia, but often no cause is identified due to the difficulty in making the diagnosis. The optimal treatment to prevent recurrences remains unknown. We performed a retrospective study of VWD patients with occult or angiodysplastic bleeding within the setting of the von Willebrand Disease Prophylaxis Network (VWD PN) to describe diagnostic and treatment strategies. Centres participating in the VWD PN recruited subjects under their care with a history of congenital VWD and gastrointestinal (GI) bleeding due to angiodysplasia, or cases in which the cause was not identified despite investigation. Patients with acquired von Willebrand syndrome or those for whom the GI bleeding was due to another cause were excluded. Forty-eight patients from 18 centres in 10 countries were recruited. Seven individuals had a family history of GI bleeding and all VWD types except 2N were represented. Angiodysplasia was confirmed in 38%, with video capsule endoscopy and GI tract endoscopies being the most common methods of making the diagnosis. Recurrent GI bleeding in VWD is associated with significant morbidity and required hospital admission on up to 30 occasions. Patients were treated with multiple pharmacological agents with prophylactic von Willebrand factor concentrate being the most efficient in preventing recurrence of the GI bleeding. The diagnosis and treatment of recurrent GI bleeding in congenital VWD remains challenging and is associated with significant morbidity. Prophylactic treatment with von Willebrand factor concentrate was the most effective method of preventing recurrent bleeding but its efficacy remains to be confirmed in a prospective study. PMID:25381842

  18. Zelltyp-spezifische Mikroanalyse von Arabidopsis thaliana-Blättern

    NASA Astrophysics Data System (ADS)

    Brandt, Stephan Peter

    2002-04-01

    Im ersten Teil der Arbeit wurden Strategien zur Analyse von Transkripten erarbeitet. Die ersten Versuche zielten darauf ab, in mit Glaskapillaren genommenen Einzelzellproben verschiedener Gewebeschichten RT-PCR durchzuführen, um spezifische Transkripte nachweisen zu können. Dies gelang für eine Reihe von Genen aus verschiedenen Pflanzenspezies. Dabei konnten sowohl Transkripte stark wie auch schwach exprimierter Gene nachgewiesen werden. Für die Erstellung von Gewebe-spezifischen Expressionsprofilen war es notwendig, die in vereinigten Zellproben enthaltene mRNA zunächst zu amplifizieren, um eine ausreichende Menge für Arrayhybridisierungen zu erhalten. Vor der Vermehrung wurde die mRNA revers transkribiert. Es wurden daran anschließend verschiedene Amplifikationsstrategien getestet: Die neben Tailing, Adapterligation und anderen PCR-basierenden Protokollen getestete Arbitrary-PCR hat sich in dieser Arbeit als einfache und einzige Methode herausgestellt, die mit so geringen cDNA-Mengen reproduzierbar arbeitet. Durch Gewebe-spezifische Array-hybridisierungen mit der so amplifizierten RNA konnten schon bekannte Expressionsmuster verschiedener Gene, vornehmlich solcher, die an der Photosynthese beteiligt sind, beobachtet werden. Es wurden aber auch eine ganze Reihe neuer offensichtlich Gewebe-spezifisch exprimierter Gene gefunden. Exemplarisch für die differentiell exprimierten Gene konnte das durch Arrayhybridisierungen gefundene Expressionsmuster der kleinen Untereinheit von Rubisco verifiziert werden. Hierzu wurden Methoden zum Gewebe-spezifischen Northernblot sowie semiquantitativer und Echtzeit-Einzelzell-RT-PCR entwickelt. Im zweiten Teil der Arbeit wurden Methoden zur Analyse von Metaboliten einschließlich anorganischer Ionen verwendet. Es stellte sich heraus, daß die multiparallele Methode der Gaschromatographie-Massenspektrometrie keine geeignete Methode für die Analyse selbst vieler vereinigter Zellinhalte ist. Daher wurde auf

  19. Die nuklearen Anlagen von Hanford (1943-1987) Eine Fallstudie über die Schnittstellen von Physik, Biologie und die US-amerikanische Gesellschaft zur Zeit des Kalten Krieges

    NASA Astrophysics Data System (ADS)

    Macuglia, Daniele

    Die Geschichte des Kalten Krieges eröffnet viele Möglichkeiten, sich näher mit den Schnittstellen von Physik und Biologie während des 20. Jahrhunderts zu befassen. Nicht nur das Unglück in Tschernobyl aus dem Jahr 1986, auch das Beispiel der nuklearen Anlagen in Hanford in den Vereinigten Staaten zeigt die biologischen Folgen von nuklearer Physik.

  20. Charakterisierung von Sulfotransferasen im Gastrointestinaltrakt von Mensch und Ratte und Aktivierung von Promutagenen in V79-Zellen, die eine intestinale Form (1B1) des Menschen und der Ratte exprimieren

    NASA Astrophysics Data System (ADS)

    Teubner, Wera

    2001-05-01

    Die Ausstattung der gastrointestinalen Mukosa des Menschen und der Ratte mit Sulfotransferasen wurde mit Hilfe von Immunodetektion und Enzymaktivitätsmessungen untersucht. In Proben aus Colon und Rektum von 39 Personen wurden die Formen h1A1, h1A3 und h1B1 identifiziert, wobei in einer weiteren Probe, die als einzige von einem an Colitis Ulcerosa erkrankten Patienten stammte, keine Sulfotransferasen nachgewiesen werden konnten. Bei der Immunblot-Analyse war das Expressionsmuster der einzelnen Formen in allen Proben ähnlich. In wenigen Proben waren die relativen Signalintensitäten der h1A1 und der h1B1 um die Hälfte erniedrigt. Der Gehalt von SULT an zytosolischem Protein zeigte einen bis zu 8 - 10fachen Unterschied, er betrug jedoch bei zwei Dritteln der Proben zwischen 0,15 und 0,3 (h1A1 und h1A3) bzw. 0,6 und 0,8 Promille (h1B1). Die Variation konnte nicht auf Alter, Geschlecht oder Krankheitsbild der Patienten zurückgeführt werden. Auch der für die allelischen Varianten der h1A1 beschriebene Effekt auf die Enzymaktiviät bzw. Stabilität konnte in der Menge an immunreaktivem Protein nicht in diesem Ausma detektiert werden. Die Allelhäufigkeit von h1A1*R und h1A1*H war gegenüber der gesunden Bevölkerung nicht verändert. In den sieben Proben aus dem Dünndarm (Coecum, viermal Ileum, Jejunum) konnten zusätzlich die Formen h1E1 und h2A1 identifiziert werden. Ein möglicherweise der Form h1C1 entsprechendes Protein wurde im Magen detektiert. Im Vergleich zum Menschen war die Expression in der Ratte stärker auf die Leber konzentriert. Während beim Menschen in allen untersuchten Abschnitten Sulfotransferasen in Mengen detektiert wurden, die in zwei Fällen (h1B1 und h1A3) sogar den Gehalt in der Leber überstiegen, beschränkte sich die Expression in der Ratte auf im Vergleich zur Leber geringe Mengen im Magen und Dickdarm. Nachgewiesen wurden die r1B1, r1A1 sowie eine nicht identifizierte Form von 35kD, bei der es sich vermutlich um die r1C2 handelt. Im

  1. Der vollständige Brief Brahes an Sørensen über das Erscheinen des Kometen von 1577

    NASA Astrophysics Data System (ADS)

    Kirschner, Stefan

    Es ist erstaunlich, daß sowohl Friis als auch Dreyer in ihrer Ausgabe der Briefe Tycho Brahes den Brief vom 14. November 1577 an Peter Sørensen, die erste bekannte Nachricht Brahes von seiner Entdeckung des Kometen von 1577, nur unvollständig, und zwar ohne den astronomischen Inhalt, ediert haben. Der Brief, dessen Original sehr wahrscheinlich nicht mehr existiert, wurde von dem Kieler Arzt und Medizinprofessor Johann Daniel Major (1634 - 1693) in Kopenhagen in sein Reisetagebuch kopiert. Das Original des Majorschen Reisetagebuches ist verschollen, doch es existieren zwei Abschriften davon (Kopenhagen, Königl. Bibl., Ny Kgl. Sml., 365, Fol. u. Ledreborg, 410, Fol.). Im folgenden wird nach einer kurzen Beschreibung des Stellenwerts, den der Komet von 1577 für Brahe besaß, der Brief nach diesen beiden Abschriften kritisch ediert, mit einer deutschen Übersetzung versehen und kurz kommentiert.

  2. Georg von Bekesy, Nobel Laureate in Physiology, Experimental Physicist and Art Collector Was Born 100 Years Ago.

    ERIC Educational Resources Information Center

    Kovacs, Laszlo

    2001-01-01

    Describes the life and accomplishments of Georg von Bekesy. Discusses his educational background and research career, and describes his extensive work on the ear, particularly the inner ear or cochlea. (SAH)

  3. Versuche zur Gewinnung von katalytischen Antikörpern zur Hydrolyse von Arylcarbamaten und Arylharnstoffen. (English Title: Attempts to produce catalytic antibodies for hydrolysis of arylcarbamates and arylureas)

    NASA Astrophysics Data System (ADS)

    Werner, Deljana

    2002-05-01

    Im Rahmen dieser Arbeit gelang es, katalytische Antikörper zur Hydrolyse von Benzylphenylcarbamaten sowie zahlreiche monoklonale Antikörper gegen Haptene herzustellen. Es wurden verschiedene Hapten-Protein-Konjugate unter Verwendung unterschiedlicher Kopplungsmethoden hergestellt und charakterisiert. Zur Generierung der hydrolytisch aktiven Antikörper wurden Inzuchtmäuse mit KLH-Konjugaten von 4 Übergangszustandsanaloga (ÜZA) immunisiert. Mit Hilfe der Hybridomtechnik wurden verschiedene monoklonale Antikörper gegen diese ÜZA gewonnen. Dabei wurden sowohl verschiedene Immunisierungsschemata als auch verschiedene Inzuchtmausstämme und Fusionstechniken verwendet. Insgesamt wurden 32 monoklonale Antikörper gegen die verwendeten ÜZA selektiert. Diese Antikörper wurden in groen Mengen hergestellt und gereinigt. Zum Nachweis der Antikörper-vermittelten Katalyse wurden verschiedene Methoden entwickelt und eingesetzt, darunter immunologische Nachweismethoden mit Anti-Substrat- und Anti-Produkt-Antikörpern und eine photometrische Methode mit Dimethylaminozimtaldehyd. Der Nachweis der hydrolytischen Aktivität gelang mit Hilfe eines Enzymsensors, basierend auf immobilisierter Tyrosinase. Die Antikörper N1-BC1-D11, N1-FA7-C4, N1-FA7-D12 und R3-LG2-F9 hydrolysierten die Benzylphenylcarbamate POCc18, POCc19 und Substanz 27. Der Nachweis der hydrolytischen Aktivität dieser Antikörper gelang auch mit Hilfe der HPLC. Der katalytische Antikörper N1-BC1-D11 wurde kinetisch und thermodynamisch untersucht. Es wurde eine Michaelis-Menten-Kinetik mit Km von 210 µM, vmax von 3 mM/min und kcat von 222 min-1 beobachtet. Diese Werte korrelieren mit den Werten der wenigen bekannten Diphenylcarbamat-spaltenden Abzyme. Die Beschleunigungsrate des Antikörpers N1-BC1-D11 betrug 10. Das ÜZA Hei3 hemmte die hydrolytische Aktivität. Dies beweist, dass die Hydrolyse in der Antigenbindungsstelle stattfindet. Weiter wurde zwischen der Antikörperkonzentration und der

  4. Determining the von Mises stress power spectral density for frequency domain fatigue analysis including out-of-phase stress components

    NASA Astrophysics Data System (ADS)

    Bonte, M. H. A.; de Boer, A.; Liebregts, R.

    2007-04-01

    This paper provides a new formula to take into account phase differences in the determination of an equivalent von Mises stress power spectral density (PSD) from multiple random inputs. The obtained von Mises PSD can subsequently be used for fatigue analysis. The formula was derived for use in the commercial vehicle business and was implemented in combination with Finite Element software to predict and analyse fatigue failure in the frequency domain.

  5. Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα

    PubMed Central

    Gitz, Eelo; Koopman, Charlotte D.; Giannas, Alèkos; Koekman, Cornelis A; van den Heuvel, Dave J.; Deckmyn, Hans; Akkerman, Jan-Willem N.; Gerritsen, Hans C.; Urbanus, Rolf T.

    2013-01-01

    Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynamic drag. The increased interaction requires shear-dependent exposure of the von Willebrand factor A1 domain, but the contribution of glycoprotein Ibα remains ill defined. We have previously found that glycoprotein Ibα forms clusters upon platelet cooling and hypothesized that such a property enhances the interaction with von Willebrand factor under physiological conditions. We analyzed the distribution of glycoprotein Ibα with Förster resonance energy transfer using time-gated fluorescence lifetime imaging microscopy. Perfusion at a shear rate of 1,600 s−1 induced glycoprotein Ibα clusters on platelets adhered to von Willebrand factor, while clustering did not require von Willebrand factor contact at 10,000 s−1. Shear-induced clustering was reversible, not accompanied by granule release or αIIbβ3 activation and improved glycoprotein Ibα-dependent platelet interaction with von Willebrand factor. Clustering required glycoprotein Ibα translocation to lipid rafts and critically depended on arachidonic acid-mediated binding of 14-3-3ζ to its cytoplasmic tail. This newly identified mechanism emphasizes the ability of platelets to respond to mechanical force and provides new insights into how changes in hemodynamics influence arterial thrombus formation. PMID:23753027

  6. [On the Awarding of the First Nobel Prize for Physiology or Medicine to Emil von Behring].

    PubMed

    Hansson, Nils; Enke, Ulrike

    2015-12-01

    In his will of 1895, the Swedish inventor Alfred Nobel laid the foundation for prizes in physics, chemistry, physiology or medicine, literature, and peace to those who had "conferred the greatest benefit on mankind" during the last year. The Nobel Prize is today widely considered as the most prestigious international symbol of scientific excellence, but it still is an exciting research question how it gained such prestige. Drawing on files from the Emil von Behring Archive in Marburg, Germany, and the Archive of the Nobel Assembly for Physiology or Medicine in Stockholm this essay aims at shedding light on why the first Nobel Prize for Physiology or Medicine in 1901 was awarded the German immunologist Emil von Behring, and how this decision was viewed at that time. This study is part of a research project that explores mechanisms leading to scientific recognition by using the example of the Nobel Prize for Physiology or Medicine.

  7. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease.

    PubMed

    Chopra, Atul R; Louet, Jean-Francois; Saha, Pradip; An, Jie; Demayo, Franco; Xu, Jianming; York, Brian; Karpen, Saul; Finegold, Milton; Moore, David; Chan, Lawrence; Newgard, Christopher B; O'Malley, Bert W

    2008-11-28

    Hepatic glucose production is critical for basal brain function and survival when dietary glucose is unavailable. Glucose-6-phosphatase (G6Pase) is an essential, rate-limiting enzyme that serves as a terminal gatekeeper for hepatic glucose release into the plasma. Mutations in G6Pase result in Von Gierke's disease (glycogen storage disease-1a), a potentially fatal genetic disorder. We have identified the transcriptional coactivator SRC-2 as a regulator of fasting hepatic glucose release, a function that SRC-2 performs by controlling the expression of hepatic G6Pase. SRC-2 modulates G6Pase expression directly by acting as a coactivator with the orphan nuclear receptor RORalpha. In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production. PMID:19039140

  8. Pathologic studies of the osteoporosis of Von Gierke's disease (glycogenosis 1a).

    PubMed

    Soejima, K; Landing, B H; Roe, T F; Swanson, V L

    1985-01-01

    Pathologic and point count-morphometric studies of ribs, vertebrae, and iliac crests of 7 patients with Von Gierke's glycogenesis type Ia aged 5 months to 30 years were performed. The bone lesion is a pure osteoporosis (reduction in mass of bone matrix) with no evidences of significant physeal cartilage abnormality or of osteitis fibrosa or osteomalacia (reduced mineralization of bone matrix). The osteoporosis was already marked in the youngest patient studied (5 months). The discrepancy between normal and glycogen storage disease (GSD) bones increased progressively with age for ribs and was less severe for vertebrae. Available biochemical data give no indication of primary disturbance of calcium or phosphate metabolism, of parathyroid activity, or of vitamin D metabolism. Clinical data suggest that the osteoporosis of Von Gierke's disease is due to hypoglycemia or a metabolic sequela thereof, such as insulinopenia, but pathologic study of patients treated by newer techniques of maintaining euglycemia in GSD is needed. PMID:3867867

  9. Instrumentation for Studies of Cochlear Mechanics: From von Békésy forward

    PubMed Central

    Nuttall, Alfred L; Fridberger, Anders

    2012-01-01

    Georg von Békésy designed the instruments needed for his research. He also created physical models of the cochlea allowing him to manipulate the parameters (such as volume elasticity) that could be involved in controlling traveling waves. This review is about the specific devices that he used to study the motion of the basilar membrane thus allowing the analysis that lead to his Nobel Prize Award. The review moves forward in time mentioning the subsequent use of von Békésy’s methods and later technologies important for motion studies of the organ of Corti. Some of the seminal findings and the controversies of cochlear mechanics are mentioned in relation to the technical developments. PMID:22975360

  10. A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia.

    PubMed

    Guerreiro de Moura, Carlos Antônio Gusmão; de Assis, Luiz Henrique; Góes, Paulo; Rosa, Fabiana; Nunes, Victor; Gusmão, Ítalo Magalhães; Cruz, Constança Margarida Sampaio

    2015-01-01

    Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the annular form. GPP may also present severe extracutaneous manifestations including pneumonitis, heart failure and hepatitis. Old reports showed a relationship between hypoparathyroidism and hypocalcemia as triggers for GPP highlighting the importance of adequate workup of the patient and possible therapeutic changes in acute situations. Here, we present a case of severe von Zumbusch psoriasis with life-threatening complications triggered by severe hypocalcemia secondary to hypoparathyroidism successfully treated with aggressive calcium reposition. PMID:26955330

  11. A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia

    PubMed Central

    Guerreiro de Moura, Carlos Antônio Gusmão; de Assis, Luiz Henrique; Góes, Paulo; Rosa, Fabiana; Nunes, Victor; Gusmão, Ítalo Magalhães; Cruz, Constança Margarida Sampaio

    2015-01-01

    Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the annular form. GPP may also present severe extracutaneous manifestations including pneumonitis, heart failure and hepatitis. Old reports showed a relationship between hypoparathyroidism and hypocalcemia as triggers for GPP highlighting the importance of adequate workup of the patient and possible therapeutic changes in acute situations. Here, we present a case of severe von Zumbusch psoriasis with life-threatening complications triggered by severe hypocalcemia secondary to hypoparathyroidism successfully treated with aggressive calcium reposition. PMID:26955330

  12. L'atteinte vésicale au cours de la neurofibromatose de Von Recklinghausen

    PubMed Central

    Benazzouz, Mohamed Hicham; Hajjad, Tilila; Essatara, Younes; El Sayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

    2014-01-01

    La neurofibromatose de type 1 ou maladie de Von Recklinghausen est une maladie génétique autosomique dominante en rapport avec des mutations dans le gène suppresseur de tumeur NF1. L'atteinte uro-génitale au cours de cette maladie est rare et moins de 80 cas ont été rapportés à ce jour dans la littérature mondiale. Les auteurs rapportent un nouveau cas d'atteinte vésicale découverte fortuitement au cours du suivi d'une patiente atteinte de la maladie de Von Recklinghausen. A travers cette observation et une revue de la littérature les auteurs discutent également les difficultés diagnostiques, thérapeutiques ainsi que les modalités de suivi dans cette maladie. PMID:25328590

  13. Jahre Entwicklung der Instandhaltung - von der ausfallorientierten Instandhaltung zum gemeinsamen TPM und RCM

    NASA Astrophysics Data System (ADS)

    Iske, Friedhelm

    Zur Einleitung meines Beitrages möchte ich von einem Gespräch mit einem Mitarbeiter berichten, das ich als junger Vorgesetzter einer Instandhaltungsgruppe 1988 führte. Der engagierte Mitarbeiter feierte damals sein vierzigjähriges Dienstjubiläum und war stolz auf das von ihm Geleistete sowie auf den besonderen Einsatz seiner Altersgruppe, die nach dem Zweiten Weltkrieg das Werk wieder aufgebaut hatte. Auf meine Frage, was denn damals die erste Aufgabe in der Firma war, bekam ich kurz und knapp und mit einer Selbstverständlichkeit die selbstbewusste Antwort: "Unser Pferd füttern und mit dem Pferd die innerbetrieblichen Transporte erledigen“. Als junger, technisch orientierter Vorgesetzter war ich über diese Antwort sehr überrascht. Gedanklich weit entfernt war die Vorstellung, dass in der Vergangenheit Transporte mit einem Pferd erledigt wurden.

  14. [On the Awarding of the First Nobel Prize for Physiology or Medicine to Emil von Behring].

    PubMed

    Hansson, Nils; Enke, Ulrike

    2015-12-01

    In his will of 1895, the Swedish inventor Alfred Nobel laid the foundation for prizes in physics, chemistry, physiology or medicine, literature, and peace to those who had "conferred the greatest benefit on mankind" during the last year. The Nobel Prize is today widely considered as the most prestigious international symbol of scientific excellence, but it still is an exciting research question how it gained such prestige. Drawing on files from the Emil von Behring Archive in Marburg, Germany, and the Archive of the Nobel Assembly for Physiology or Medicine in Stockholm this essay aims at shedding light on why the first Nobel Prize for Physiology or Medicine in 1901 was awarded the German immunologist Emil von Behring, and how this decision was viewed at that time. This study is part of a research project that explores mechanisms leading to scientific recognition by using the example of the Nobel Prize for Physiology or Medicine. PMID:26676474

  15. An efficient method for calculating RMS von Mises stress in a random vibration environment

    SciTech Connect

    Segalman, D.J.; Fulcher, C.W.G.; Reese, G.M.; Field, R.V. Jr.

    1998-02-01

    An efficient method is presented for calculation of RMS von Mises stresses from stress component transfer functions and the Fourier representation of random input forces. An efficient implementation of the method calculates the RMS stresses directly from the linear stress and displacement modes. The key relation presented is one suggested in past literature, but does not appear to have been previously exploited in this manner.

  16. An efficient method for calculating RMS von Mises stress in a random vibration environment

    SciTech Connect

    Segalman, D.J.; Fulcher, C.W.G.; Reese, G.M.; Field, R.V. Jr.

    1997-12-01

    An efficient method is presented for calculation of RMS von Mises stresses from stress component transfer functions and the Fourier representation of random input forces. An efficient implementation of the method calculates the RMS stresses directly from the linear stress and displacement modes. The key relation presented is one suggested in past literature, but does not appear to have been previously exploited in this manner.

  17. Finite element approximation of an optimal control problem for the von Karman equations

    NASA Technical Reports Server (NTRS)

    Hou, L. Steven; Turner, James C.

    1994-01-01

    This paper is concerned with optimal control problems for the von Karman equations with distributed controls. We first show that optimal solutions exist. We then show that Lagrange multipliers may be used to enforce the constraints and derive an optimality system from which optimal states and controls may be deduced. Finally we define finite element approximations of solutions for the optimality system and derive error estimates for the approximations.

  18. A note on the numerical solution of the von Karman small disturbance equation

    NASA Astrophysics Data System (ADS)

    Pilant, M. S.

    1985-09-01

    In this short note, the von Karman small disturbance equation is derived from the full potential equation of gas dynamics through perturbation methods. Guderley (1962) and Germain (1964) have previously computed exact solutions, in similarity form, for the small disturbance equation. It is shown that these solutions can be computed efficiently by solving a single nonlinear second-order differential equation. The shock and entropy conditions are automatically satisfied, and a one-parameter family of solutions is recovered.

  19. [Carl Friedrich von Weizsäcker's philosophy of the mind].

    PubMed

    Lyre, Holger

    2014-01-01

    The paper deals with Carl Friedrich von Weizsäcker's position within the philosophy of mind. It turns out that Weizsäcker's ontology is based on an unorthodox conception both in the philosophy of physics and in the philosophy of mind. His quantum information theoretic reductionism is based on a subtle combination of atomism and holism, his philosophy of mind connected to this is a neutral monism, which proposes a bold intertwining of mind, matter, and space.

  20. The work of Rosa von Praunheim: tackling AIDS in Germany through film.

    PubMed

    Judell, B

    1996-10-01

    Rosa von Praunheim, a film maker, and the most famous (or infamous) homosexual in Germany, has spurred the creation of gay rights groups from Bavaria to Schleswig-Holstein. His AIDS comedy, A Virus Has No Morals, was one of the first films to confront the disease internationally. Other works, in both fictional and documentary formats, address AIDS activism, living with AIDS, and other social issues concerning AIDS and the gay community. PMID:11363912