Lemmel, Frédéric; ter Haar, Jörg; van der Biezen, John; Duvet, Ludovic; Nelms, Nick; Blommaert, Sander; Butler, Bart; van der Luijt, Cornelis; Heijnen, Jerko; Smit, Hans; Visser, Ivo
For future near infrared astronomy missions, ESA is developing a complete detection and conversion chain (photon to SpaceWire chain system): Large Format Array (aLFA-N) based on MCT type detectors. aLFA-C (Astronomy Large Format Array Controller): a versatile cryogenic detector controller. An aLFA-C prototype was developed by Caeleste (Belgium) under ESA contract (400106260400). To validate independently the performances of the aLFA-C prototype and consolidate the definition of the follow-on activity, a dedicated test bench has been designed and developed in ESTEC/ESA within the Payload Technology Validation group. This paper presents the test setup and the performance validation of the first prototype of this controller at room and cryogenic temperature. Test setup and software needed to test the HAWAII-2RG and aLFA-N detectors with the aLFA-C prototype at cryogenic temperature will be also presented.
Llebot, Clara; Rueda, Francisco J.; Solé, Jordi; Artigas, Mireia Lara; Estrada, Marta
A conceptual model of the physical behavior of a shallow (6 m deep) micro-tidal estuary (Alfacs Bay) is proposed, based on the interpretation of a field data set, and subsequently tested against the results of three-dimensional hydrodynamic simulations. At seasonal timescales, the buoyancy associated with freshwater inflows dominates the tidal forcing, yielding a strongly stratified two-layered system, with the surface and the bottom layers flowing in opposite directions (classical estuarine circulation). Wind controls the physical behavior of the bay at shorter (days to weeks) timescales. Three scenarios or states have been defined, depending on the strength of stratification relative to the predominant direction and magnitude of the wind forcing, parameterized through the Wedderburn number, W. For weak winds (scenario 1), with W ≫ 1, mixing occurs as a consequence of stirring and convective cooling, and the mixed layer deepens slowly. For strong winds, with W ≪ 1/2, mixing is fast and is largely driven by shear at the pycnocline. Two scenarios are further identified for W ≪ 1/2 depending on the directionality of the winds: one for persistent NW winds (scenario 2) and another for diurnal SW winds (scenario 3). In scenario 2, the water is pushed laterally, overturning the stratification and generating transverse density gradients. In scenario 3, the estuarine circulation is weakened and even reversed, yielding strong longitudinal density gradients. The bay waters relax quickly (within 10-18 h) back to the original state, after the wind ceases, as a result of the horizontal density gradients developed under wind forcing. Bay-sea exchange rates are shown to decrease significantly in the low W scenarios, the magnitudes of these changes being largely dependent on wind direction. These scenarios have important implications for the ecology of the bay, including the occurrence of phenomena such as harmful algal blooms.
Carrasco, N; López-Flores, I; Alcaraz, M; Furones, M D; Berthe, F C J; Arzul, I
Since the first description of Marteilia refringens (Paramyxea) in flat oysters Ostrea edulis in 1968 in the Aber Wrach, Brittany (France), the life-cycle of this parasite has remained unknown. However, recent studies, conducted in the 'claire' system, have proposed the planktonic copepod Acartia grani as a potential intermediate host for the parasite. Nevertheless, experimental transmission of the parasite through the copepod has failed. Recent studies in this field have reported the presence of the parasite in zooplankton from the bays of the Delta de l'Ebre, a more complex and natural estuarine environment than that of the claire. As a result, 2 new Marteilia host species were proposed: the copepods Oithona sp. (Cyclopoida) and an indeterminate Harpaticoida. Consequently, the objective of the present work was to study the dynamics of Marteilia in the zooplankton community from one of the bays, Alfacs Bay, as well as the dynamics of the parasite in cultivated mussels during 1 complete year. Six different zooplankton taxa appeared to be parasitized by M. refringens, including copepods (3 Calanoida, Acartia discaudata, A. clausi and A. italica; 1 Cyclopoida, Oithona sp.; and 1 Harpacticoida, Euterpina acutifrons), and larval stages of decapod crustaceans (zoea larvae of Brachyura, probably Portumnus sp.). These taxa are thus proposed as new subjects for study, since they could be intermediate hosts in the infection process of mussels by Marteilia.
This study investigated the effects of green tea polyphenols (GTP) and alfacalcidol on bone microstructure and strength along with possible mechanisms in rats with chronic inflammation. A 12-week study using a 2 (no GTP vs. 0.5%, w/v GTP in drinking water) × 2 (no alfacalcidol vs. 0.05 ug/kg alfacal...
Barchi, Leandro Cardoso; Jacob, Carlos Eduardos; Bresciani, Cláudio José Caldas; Yagi, Osmar Kenji; Mucerino, Donato Roberto; Lopasso, Fábio Pinatel; Mester, Marcelo; Ribeiro-Júnior, Ulysses; Dias, André Roncon; Ramos, Marcus Fernando Kodama Pertille; Cecconello, Ivan; Zilberstein, Bruno
Minimally invasive surgery widely used to treat benign disorders of the digestive system, has become the focus of intense study in recent years in the field of surgical oncology. Since then, the experience with this kind of approach has grown, aiming to provide the same oncological outcomes and survival to conventional surgery. Regarding gastric cancer, surgery is still considered the only curative treatment, considering the extent of resection and lymphadenectomy performed. Conventional surgery remains the main modality performed worldwide. Notwithstanding, the role of the minimally invasive access is yet to be clarified. To evaluate and summarize the current status of minimally invasive resection of gastric cancer. A literature review was performed using Medline/PubMed, Cochrane Library and SciELO with the following headings: gastric cancer, minimally invasive surgery, robotic gastrectomy, laparoscopic gastrectomy, stomach cancer. The language used for the research was English. 28 articles were considered, including randomized controlled trials, meta-analyzes, prospective and retrospective cohort studies. Minimally invasive gastrectomy may be considered as a technical option in the treatment of early gastric cancer. As for advanced cancer, recent studies have demonstrated the safety and feasibility of the laparoscopic approach. Robotic gastrectomy will probably improve outcomes obtained with laparoscopy. However, high cost is still a barrier to its use on a large scale. A cirurgia minimamente invasiva amplamente usada para tratar doenças benignas do aparelho digestivo, tornou-se o foco de intenso estudo nos últimos anos no campo da oncologia cirúrgica. Desde então, a experiência com este tipo de abordagem tem crescido, com o objetivo de fornecer os mesmos resultados oncológicos e sobrevivência à cirurgia convencional. Em relação ao câncer gástrico, o tratamento cirúrgico ainda é considerado o único tratamento curativo, considerando a extensão da
Galimany, Eve; Ramón, Montserrat; Delgado, Maximino
Alfacs Bay is a N.W. Mediterranean estuary important for mussel (Mytilus galloprovincialis) aquaculture. During studies at the site, fiberglass particles were detected. The presence of fiberglass occurred naturally in the water throughout the study period (November 2006 to July 2007). An investigation was undertaken into its role in the feeding behavior of the local mussels. Fiberglass was present in all types of mussel samples. Rejection, which we would have expected for the whole study period, was only evident during the second season studied. To our knowledge, this is the first report of the ingestion of fiberglass by a marine organism. Our novel finding indicates the need to investigate fiberglass ingestion by marine organisms at different levels of the food web and the possible implications for human health and the health of the organisms themselves. In addition, we propose the use of mussels as sentinel organisms to monitor fiberglass contamination in marine ecosystems.
Fernández-Tejedor, Margarita; Soubrier-Pedreño, M Angeles; Furones, M Dolores
Between January and April 2000, several experiments were performed during a Karlodinium spp. proliferation in Alfacs Bay (Ebro delta, NW Mediterranean) to determine the effects of these dinoflagellates on sea bream Sparus aurata cultivated in the area. Moribund fish showed an increase in plasma osmolality together with a decrease in the haematocrit percentage compared to control fish. The efficacy of copper sulphate, hydrogen peroxide, potassium permanganate and formalin against Karlodinium spp. was also tested. None of these treatments had mitigation effects when applied in the presence of fish; on the contrary, lethal effects appeared at lower Karlodinium spp. densities compared to fish control groups. When a lytic agent, such as copper sulphate, was used as a water pre-treatment, in the absence of fish, Karlodinium spp. toxicity was significantly reduced. Protocols for water pre-treatments were studied as a potential tool for combating Karlodinium spp. in fish farms.
Terra, Ricardo Mingarini; Andrade, Juliano Ribeiro; Mariani, Alessandro Wasum; Garcia, Rodrigo Gobbo; Succi, Jose Ernesto; Soares, Andrey; Zimmer, Paulo Marcelo
The concept of a hybrid operating room represents the union of a high-complexity surgical apparatus with state-of-the-art radiological tools (ultrasound, CT, fluoroscopy, or magnetic resonance imaging), in order to perform highly effective, minimally invasive procedures. Although the use of a hybrid operating room is well established in specialties such as neurosurgery and cardiovascular surgery, it has rarely been explored in thoracic surgery. Our objective was to discuss the possible applications of this technology in thoracic surgery, through the reporting of three cases. RESUMO O conceito de sala híbrida traduz a união de um aparato cirúrgico de alta complexidade com recursos radiológicos de última geração (ultrassom, TC, radioscopia e/ou ressonância magnética), visando a realização de procedimentos minimamente invasivos e altamente eficazes. Apesar de bem estabelecido em outras especialidades, como neurocirurgia e cirurgia cardiovascular, o uso da sala hibrida ainda é pouco explorado na cirurgia torácica. Nosso objetivo foi discutir as aplicações e as possibilidades abertas por essa tecnologia na cirurgia torácica através do relato de três casos.
Cerralbo, Pablo; Grifoll, Manel; Espino, Manuel
The Ebro Delta (NW Mediterranean Sea) is characterized by the presence of two semi-enclosed bays: Alfacs and Fangar. Both bays receive direct freshwater input from drain channels of rice fields. Southern Bay, Alfacs, is about 14km long by 4km wide with an average depth of about 3.1 m (maximum of 6.5 m in the middle). The mouth is about 2.5 km wide. The non-tidal flow in the area has been studied in the past, showing a persistent structure during most of the year: a salty layer in the bottom and freshwater layer on top due to freshwater input. The bay is micro-tidal, with a mixed tidal regime. An extensive field campaign was designed in order to characterize the hydrodynamic and T/S patterns during summer. First CTD transects were conducted during June 2012 and July 2013. Moreover, the positions of lagrangian drifters were tracked recording trajectories at sub-surface waters. Finally, two moored stations (within the Bay and Mouth) allowed to obtain hydrodynamic and T/S conditions during two-month period in summer 2013. Atmospheric data were obtained from three fixed land stations. Data analysis showed density differences from surface to bottom in the middle of the bay around 3-5 kg/m3 and almost constant over all the period. The density profiles seems to be controlled mainly from freshwater contributions (differences of 1.5 in salinity), although heat fluxes in summer contributes positively to the column stabilization (maximum vertical temperature differences of 5-6ºC). Observed well-mixed conditions were related with energetic wind events (northerly winds). The variability on water circulation is dominated by seiches (3h and 1h), with a clear barotropic mode and maximum intensities of 50 cm·s-1. These variability is modulated by diurnal winds (sea breeze regimes). On the other hand, low frequency motion is controlled by baroclinic estuarine circulation.
Rodellas, Valentí; Garcia-Orellana, Jordi; Trezzi, Giada; Masqué, Pere; Stieglitz, Thomas C.; Bokuniewicz, Henry; Cochran, J. Kirk; Berdalet, Elisa
The specific ingrowth rates of different radium isotopes make them valuable tracers to distinguish processes occurring at different temporal scales. Here we demonstrate the use of the radium quartet (223Ra, 224Ra, 226Ra and 228Ra) to differentiate flows of submarine groundwater discharge and porewater exchange to a coastal embayment (Alfacs Bay, NW Mediterranean Sea), based on the assumption that these processes occur on different time scales. In order to evaluate the seasonal dynamics of groundwater and porewater inputs to the bay, we conducted three seasonal samplings at Alfacs Bay, during which samples for Ra isotopes were collected from bay waters, groundwater springs, porewaters and irrigation channels. Activities of short-lived Ra isotopes in the bay showed a strong seasonality, (e.g. average 224Ra activities in summer (∼32 dpm 100 L-1) up to 4 times higher than in winter (∼8 dpm 100 L-1)). In contrast, the activities of the long-lived Ra isotopes were fairly constant throughout the year (e.g. activities of 226Ra were ∼16 and ∼14 dpm 100 L-1 in summer and winter, respectively). The relatively short exposure to sediments of recirculation fluxes resulted in porewaters significantly enriched in short-lived Ra isotopes relative to the long-lived ones (e.g. 224Ra = 1100-1300 dpm 100 L-1; 226Ra = 17-99 dpm 100 L-1), whereas coastal groundwaters were enriched in all the Ra isotopes (e.g. 224Ra = 120-150 dpm 100 L-1; 226Ra = 200-400 dpm 100 L-1). The distinct signatures of different sources allowed us to construct seasonal Ra mass balances to estimate both groundwater discharge, which ranges from (40 ± 60)·103 m3·d-1 in summer to (310 ± 200)·103 m3·d-1 in winter, and porewater exchange fluxes, ranging from (1200 ± 120)·103 m3·d-1 in summer to (270 ± 40)·103 m3·d-1 in winter. Whereas the seasonal variability of groundwater inputs is likely governed by the terrestrial hydraulic gradient, a qualitative evaluation of the drivers of porewater exchange
Mascaró, O.; Romero, J.; Pérez, M.
In temperate regions, climatic factors impose a general seasonal pattern on seagrass growth that can be observed in leaf growth rates and, in small species, also in shoot density. Large variations in shoot density suggest a strong temporal uncoupling between shoot recruitment and shoot mortality, and the dependence of each of these processes on different drivers. Here we examine seasonal patterns of recruitment and mortality in the seagrass Cymodocea nodosa, one of the species most sensitive to seasonal forcing in the Mediterranean. We sampled two local populations submitted to different nutrient availability in Alfacs Bay (NW Mediterranean) and determined recruitment and mortality rates, as well as other plant traits, on a monthly basis. Our results confirm the hypothesized uncoupling, with maximum mortality 2 months after maximum recruitment. Whereas timing of recruitment was associated with light availability, and was supported by carbohydrate remobilisation, mortality was related to high water temperatures and probably also to light limitation in late summer due to self-shading. In the high-nutrient population, algal overgrowth caused further light deprivation, with mortality rates higher than in the low-nutrient population. It is emphasised that the demographic balance of the studied populations was negative for most of the year, with the exception of August and September. Therefore, caution is necessary when overall population trends are inferred from single annual sampling events.
Rivetti, Claudia; Gómez-Canela, Cristian; Lacorte, Silvia; Barata, Carlos
Microcystins, anatoxins and okadaic acid are toxins produced by freshwater cyanobacteria and marine dinoflagellates. These toxins have been the responsible for the illness and death of biota and humans. To determine their presence in water during blooms, sensitive analytical methods are needed. In this study, we have developed a new liquid chromatography tandem mass spectrometry (LC-MS/MS) method for fast multiresidue determination of five toxins in suspended material and sediment samples. For each target compound, two selected reaction monitoring (SRM) transitions were optimised. Chromatographic conditions were optimised considering that the compounds analysed had different chemical structure and chromatographic behaviour. Using a Luna C18 column and specific SRM transitions, five phytotoxins were resolved. Method detection limits (MDL) for anatoxin-a, microcystins RR, LR and YR and okadaic acid were 7.1, 3.3, 81.7, 102.8 and 28.8 ng g(-1) dry weight in sediment, respectively. The developed analytical method was successfully applied to analyse the presence of toxins in suspended solids and sediment from Ebro River (NE Spain) and Ebro delta-associated lagoons. Anatoxin-a was detected downstream of the Riba-Roja reservoir with levels ranging from 20 to 1120 ng g(-1) dry weight of suspended solids. Okadaic acid was only detected in three samples collected in the Alfacs Bay (Ebro delta, Spain) affected by Dinophysis blooms in 2012.
Carrasco, N; Villalba, A; Andree, K B; Engelsma, M Y; Lacuesta, B; Ramilo, A; Gairín, I; Furones, M D
Bonamia exitiosa and Bonamia ostreae are parasites that reproduce within the haemocytes of several oyster species. In Europe, the host species is the flat oyster Ostrea edulis. The parasite B. ostreae has been responsible for mortalities since the late 1970s throughout the European Atlantic coast. B. exitiosa was first detected, in 2007, on this continent in flat oysters cultured in Galicia (NW Spain). Since then, the parasite has also been detected in France, Italy and the United Kingdom. The bays of the Ebro Delta in the south of Catalonia represent the main bivalve culture area in the Mediterranean coast of Spain. Previous information from the area includes reports of several flat oyster pathogens, including the notifiable parasite Marteilia refringens. However, the status with regard to Bonamia parasites was uncertain. In the present study, a Bonamia parasite was observed in flat oysters cultured in the Alfacs Bay of the Ebro Delta by histology and real-time PCR. PCR-RFLP and sequencing suggested the presence of B. exitiosa. Finally, phylogenetic analyses of the studied Bonamia isolates corroborated B. exitiosa infection. M. refringens was also observed in the same oyster batch, and co-infection with both parasites was also detected. This is the first detection of B. exitiosa, in Catalonia and the Spanish Mediterranean coast. The impact of the parasite on the Mediterranean flat oyster activity needs to be urgently addressed. Copyright © 2012 Elsevier Inc. All rights reserved.
Park, Ji-Soo; Tang, Yingjie; Davis, Robert; Nemanich, Robert
N- and Al-polar (0001) wurtzite AlN films were grown on C- and Si-polar 6H-SiC substrates, respectively. The polarity was confirmed by KOH chemical etching and atomic force microscopy (AFM) imaging. The surfaces were cleaned in situ by annealing to ˜1100^oC in a flux of ammonia, and X-ray photoemission spectroscopy (XPS) and UV photoemission spectroscopy (UPS) were employed to measure the electronic states at the surfaces. The results indicated a similar electron affinity for both surfaces which appears to approach a value of zero. Furthermore, it was determined that the Fermi energy (Ec-Ef) was 2.4 eV below the conduction band for N-face AlN and 3.0 eV for Al-face AlN. The 0.6eV difference in the Fermi energy indicates a difference in band bending near the surface which is discussed in terms of the built-in field induced by the polarization bound surface charges.
Margulis, L.; Navarrete, A.; Sole, M.
Inocula from organic-rich black muds immediately underlying intertidal laminated microbial mats dominated by Microcoleus chthonoplastes yielded large, variable diameter spirochetes. These unusual spirochetes, previously reported only from the Alfacs Peninsula at the delta of the Ebro river in northeast Spain, contain striking arrays of cytoplasmic granules packed into their protoplasmic cylinders. On several occasions, both in summer and winter, the huge spirochetes were recognized in samples from mats growing in the Sippewissett salt marsh at Woods Hole Massachusetts. They were also seen in similar samples from microbial mats at North Pond, Laguna Figueroa, Baja California Norte, Mexico. The identity of these spirochetes was confirmed by electron microscopy: number and disposition of flagella, composite structure, measurements of their distinctive cytoplasmic granules. The granules, larger, more conspicuous and present in addition to ribosomes, are hypothesized to contain ATPases. As culture conditions worsen, these spirochetes retract into membrane-bounded round bodies in which they form refractile inclusions. From morphology and behavior we conclude the North American spirochetes from both Atlantic and Pacific intertidal microbial mats are indistinguishable from those at the delta of the Ebro river. We conclude a cosmopolitan distribution for Spirosymplokos deltaeiberi.
Chulam, Thiago Celestino; Lira, Renan Bezerra; Kowalski, Luiz Paulo
to evaluate the thickness of the gastric wall at the time of intra gastric balloon (IGB) placement, at the time of its withdrawal and one month after withdrawal. fifteen morbidly obese patients underwent the introduction of IGB under general anesthesia. In all patients, there was infusion of 500ml of distilled water in the balloon for the test. Measurements of the thickness of the gastric wall were made in the antrum, body and proximal body, using a radial echoendoscope with a frequency of 12MHz and maximum zoom, and its own balloon inflated with 5ml of distilled water. the presence of IGB led to increased wall thickness of the gastric body by expanding the muscle layer. These changes were apparently transient, since 30 days after the balloon withdrawal there was a tendency to return of the wall thickness values observed before the balloon insertion. the use of intragastric balloon for the treatment of obesity determines transient increase in the wall thickness of the gastric body caused by expanded muscle layer. A preocupação com a melhoria dos resultados estéticos e funcionais sem comprometimento dos resultados oncológicos na cirurgia de cabeça e pescoço tem aumentado significativamente. Os procedimentos minimamente invasivos e principalmente aqueles que utilizam a tecnologia robótica permitiram o desenvolvimento de novas abordagens, incluindo o acesso retroauricular, que agora é usado rotineiramente, especialmente na Coréia do Sul. A presente nota irá ilustrar a técnica e a experiência inicial na América Latina, demonstrando que esta abordagem é viável, segura e eficaz oncologicamente, podendo ser utilizada em casos selecionados com um benefício estético evidente.
Gonçalves-Araujo, Rafael; Wiegmann, Sonja; Torrecilla, Elena; Bardaji, Raul; Röttgers, Rüdiger; Bracher, Astrid; Piera, Jaume
The detection and prediction of changes in coastal ecosystems require a better understanding of the complex physical, chemical and biological interactions, which involves that observations should be performed continuously. For this reason, there is an increasing demand for small, simple and cost-effective in situ sensors to analyze complex coastal waters at a broad range of scales. In this context, this study seeks to explore the potential of beam attenuation spectra, c(λ), measured in situ with an advanced-technology optical transmissometer, for assessing temporal and spatial patterns in the complex estuarine waters of Alfacs Bay (NW Mediterranean) as a test site. In particular, the information contained in the spectral beam attenuation coefficient was assessed and linked with different biogeochemical variables. The attenuation at λ = 710 nm was used as a proxy for particle concentration, TSM, whereas a novel parameter was adopted as an optical indicator for chlorophyll a (Chl-a) concentration, based on the local maximum of c(λ) observed at the long-wavelength side of the red band Chl-a absorption peak. In addition, since coloured dissolved organic matter (CDOM) has an important influence on the beam attenuation spectral shape and complementary measurements of particle size distribution were available, the beam attenuation spectral slope was used to analyze the CDOM content. Results were successfully compared with optical and biogeochemical variables from laboratory analysis of collocated water samples, and statistically significant correlations were found between the attenuation proxies and the biogeochemical variables TSM, Chl-a and CDOM. This outcome depicted the potential of high-frequency beam attenuation measurements as a simple, continuous and cost-effective approach for rapid detection of changes and patterns in biogeochemical properties in complex coastal environments. PMID:28107539
Macedo, Antonio Luiz de Vasconcellos; Schraibman, Vladimir
The intraoperative identification of certain anatomical structures because they are small or visually occult may be challenging. The development of minimally invasive surgery brought additional difficulties to identify these structures due to the lack of complete tactile sensitivity. A number of different forms of intraoperative mapping have been tried. Recently, the near-infrared fluorescence imaging technology with indocyanine green has been added to robotic platforms. In addition, this technology has been tested in several types of operations, and has advantages such as safety, low cost and good results. Disadvantages are linked to contrast distribution in certain clinical scenarios. The intraoperative near-infrared fluorescent imaging is new and promising addition to robotic surgery. Several reports show the utility of this technology in several different procedures. The ideal dose, time and site for dye injection are not well defined. No high quality evidence-based comparative studies and long-term follow-up outcomes have been published so far. Initial results, however, are good and safe. RESUMO A identificação intraoperatória de certas estruturas anatômicas, por seu tamanho ou por elas serem ocultas à visão, pode ser desafiadora. O desenvolvimento da cirurgia minimamente invasiva trouxe dificuldades adicionais, pela falta da sensibilidade tátil completa. Diversas formas de detecção intraoperatória destas estruturas têm sido tentadas. Recentemente, a tecnologia de fluorescência infravermelha com verde de indocianina foi associada às plataformas robóticas. Além disso, essa tecnologia tem sido testada em uma variedade de cirurgias, e suas vantagens parecem estar ligadas a baixo custo, segurança e bons resultados. As desvantagens estão associadas à má distribuição do contraste em determinados cenários. A imagem intraoperatória por fluorescência infravermelha é uma nova e promissora adição à cirurgia robótica. Diversas séries mostram
Carvalho, Lilian Regina de; Évora, Yolanda Dora Martinez; Zem-Mascarenhas, Silvia Helena
to assess the usability of a digital learning technology prototype as a new method for minimally invasive monitoring of intracranial pressure. descriptive study using a quantitative approach on assessing the usability of a prototype based on Nielsen's ten heuristics. Four experts in the area of Human-Computer interaction participated in the study. the evaluation delivered eight violated heuristics and 31 usability problems in the 32 screens of the prototype. the suggestions of the evaluators were critical for developing an intuitive, user-friendly interface and will be included in the final version of the digital learning technology. avaliar a usabilidade de um protótipo educacional digital sobre um novo método para monitoração da pressão intracraniana de forma minimamente invasivo para enfermeiros e médicos. estudo descritivo com abordagem quantitativa sobre a avaliação de usabilidade de um protótipo com base nas dez Heurísticas de Nielsen. Participaram quatro especialistas da área de Interação Humano Computador. a avaliação resultou em oito heurísticas violadas e 31 problemas de usabilidade nas 32 telas do protótipo. as sugestões dos avaliadores foram cruciais para o desenvolvimento de uma interface amigável e intuitiva e serão consideradas na versão final da tecnologia educacional digital. evaluar la usabilidad de un prototipo educacional digital sobre un nuevo método para monitorización de la presión intracraneal, de manera mínimamente invasiva. estudio descriptivo con abordaje cuantitativo sobre la evaluación de usabilidad de un prototipo con base en las diez reglas Heurísticas de Nielsen. Participaron cuatro especialistas del área de Interacción Humana Computador. la evaluación resultó en ocho reglas heurísticas violadas y 31 problemas de usabilidad en las 32 pantallas del prototipo. las sugestiones de los evaluadores fueron cruciales para el desarrollo de una interfaz amigable e intuitiva y éstas serán consideradas en la
Busch, Julia A.; Price, Ivan; Jeansou, Eric; Zielinski, Oliver; van der Woerd, Hendrik J.
Ocean colour measurements from space are well suited to assess phytoplankton dynamics over broad spatial scales. Closer to the coast however, the quality of these data degrades as a result of the loading of sediments and dissolved matter from terrestrial runoff, the influences of land reflection on atmospheric correction and sea-bottom reflection, which compromise their use in coastal management actions. Recently, the enabling of citizens to provide environmental observations has gained recognition as a way for enhancing the spatio-temporal coverage of satellite observations. In the FP7 funded EU project "Citclops" (Citizens' observatory for coast and ocean optical monitoring), a smart phone app for the classification of water colour, simplified to 21 hues of the Forel Ule (FU) scale, is developed. In this study we examine two bays in the Ebro Delta (NW Mediterranean) where satellite data, hyperspectral measurements, and observations with the citizen tool for colour comparison were available. FU values and their corresponding novel colorimetric parameter, the hue colour angle, were derived in the bay at 12 stations with the traditional FU scale and one automated in-situ radiometric system at the Alfacs Bay aquaculture site. Both methods complied well during the study course of May-June 2011. These measurements were further compared to data from Full Resolution MERIS (Medium Resolution Imaging Spectrometer) satellite images. The quality of the retrieved hue angle varies over the image. For high-quality sites, MERIS hue colour angles and FU values gave a good estimate of seasonal algal dynamics in the bays over the year 2011, while ground measurements revealed colour changes over short space- and time frames, which are indicative of the fast dynamics of phytoplankton in the area that could not be fully resolved with MERIS data. The use of FU values and hue colour angle of water will allow a simple integration of data from hyperspectral measurements, MERIS
Mori, Satomi; Takeda, Juliana Rumy Tsuchihashi; Carrara, Fernanda Souza Angotti; Cohrs, Cibelli Rizzo; Zanei, Suely Sueko Viski; Whitaker, Iveth Yamaguchi
To identify the incidence of delirium, compare the demographic and clinical characteristics of patients with and without delirium, and verify factors related to delirium in critical care patients. Prospective cohort with a sample made up of patients hospitalized in the Intensive Care Unit (ICU) of a university hospital. Demographic, clinical variables and evaluation with the Confusion Assessment Method for Intensive Care Unit to identify delirium were processed to the univariate analysis and logistic regression to identify factors related to the occurrence of delirium. Of the total 149 patients in the sample, 69 (46.3%) presented delirium during ICU stay, whose mean age, severity of illness and length of ICU stay were statistically higher. The factors related to delirium were: age, midazolam, morphine and propofol. Results showed high incidence of ICU delirium associated with older age, use of sedatives and analgesics, emphasizing the need for relevant nursing care to prevent and identify early, patients presenting these characteristics. Identificar a incidência de delirium, comparar as características demográficas e clínicas dos pacientes com e sem delirium e verificar os fatores relacionados ao delirium em pacientes internados em Unidade de Terapia Intensiva (UTI). Coorte prospectiva, cuja amostra foi constituída de pacientes internados em UTI de um hospital universitário. Variáveis demográficas, clínicas e da avaliação com o Confusion Assessment Method for Intensive Care Unit para identificação de delirium foram processadas para análise univariada, e regressão logística para identificar fatores relacionados à ocorrência do delirium. Do total de 149 pacientes da amostra, 69 (46,3%) apresentaram delirium durante a internação na UTI, observando-se que a média da idade, o índice de gravidade e o tempo de permanência nas UTI foram estatisticamente maiores. Os fatores relacionados ao delirium foram: idade, midazolam, morfina e propofol. Os
Lopez-Nava, Gontrand; Galvão, M P; Bautista-Castaño, I; Fernandez-Corbelle, J P; Trell, M; Lopez, N
Bariatric endoscopic techniques are minimally invasive and induce gastric volume reduction to treat obesity. Aim : To evaluate endoscopic sleeve gastroplasty (Apollo method) using a suturing method directed at the greater curvature, as well as the perioperative care, two year safety and weight loss. Prospective single-center study over 154 patients (108 females) using the endoscopic sleeve gastroplasty procedure under general anesthesia with overnight inpatient observation. Of the154 initial patients, 143 were available for 1-month of follow-up, 133 for 6-month, 64 for 12-month and 28 completed the 24 month assessment. Follow-up was carried out by a multidisciplinary team (nutritionist and psychologist). Outcomes evaluated were: change in BMI; change in body weight (TBWL); % of loss of initial body weight (%TBWL); % of excess body weight loss (%EWL) (segregated in > or <25% and adverse effects. Voluntary oral contrasted radiological examinations were scheduled to assess the gastroplasty at different times post-procedure. Mean age was 44.9 (23-69) years. At 24 months after the procedure baseline mean BMI change from 38.3 to 30.8 kg/m2. TBWL, %TBWL and %EWL were of 21.3 kg, 19.5% and 60.4% respectively. 85.7% of patients achieve the goal of >25% %EWL. There were no mayor adverse events intraprocedure or during the 24 months of follow-up . Endoscopic sleeve gastroplasty with regular monitoring by a multidisciplinary team can be considered an effective, safe and well tolerated procedure for obesity treatment, at least for two years of follow-up. As técnicas de endoscopia bariátrica são minimamente invasivas e induzem à redução do volume gástrico para tratar a obesidade. Avaliar a gastroplastia sleeve endoscópica (método Apollo) usando um método de sutura direcionado para a grande curvatura, bem como os cuidados perioperatórios, segurança em dois anos e perda de peso. Estudo prospectivo em um único centro com 154 pacientes (108 mulheres) usando o
El Ouahabi, Meriam; Hubert-Ferrari, Aurelia; Lamair, Laura; Hage, Sophie
Turbidites have been extensively studied in many different areas using cores or outcrop, which represent only an integrated snapshot of a dynamic evolving flow. Laboratory experiments provide the missing relationships between the flow characteristics and their deposits. In particular, flume experiments emphasize that the presence of clay plays a key role in turbidity current dynamics. Clay fraction, in small amount, provides cohesive strength to sediment mixtures and can damp turbulence. However, the degree of flocculation is dependent on factors such as the amount and size of clay particles, the surface of clay particles, chemistry and pH conditions in which the clay particles are dispersed. The present study focuses on thin clayey sand turbidites found in Lake Hazar (Turkey) occurring in stacked thin beds. Depositional processes and sources have been previously studied and three types were deciphered, including laminar flows dominated by cohesion, transitional, and turbulence flow regimes (Hage et al., in revision). For the purpose of determine the clay behavior in the three flow regimes, clay mineralogical, geochemical measurements on the cores allow characterising the turbidites. SEM observations provide further information regarding the morphology of clay minerals and other clasts. The study is particularly relevant given the highly alkaline and saline water of the Hazar Lake. Clay minerals in Hazar Lake sediments include kaolinite (1:1-type), illite and chlorite (2:1-type). Hazar lake water is alkaline having pH around 9.3, in such alkaline environment, a cation-exchange reaction takes place. Furthermore, in saline water (16‰), salts can act as a shield and decrease the repulsive forces between clay particle surfaces. So, pH and salt content jointly impact the behaviour of clays differently. Since the Al-faces of clay structures have a negative charge in basic solutions. At high pH, all kaolinite surfaces become negative-charged, and then kaolinite