78 FR 36635 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

.../ofac ) or via facsimile through a 24-hour fax-on demand service at (202) 622-0077. Background On October 21, 1995, the President, invoking the authority, inter alia, of the International Emergency... 24, 1995) (the ``Order''). In the Order, the President declared a national emergency to deal with the...

Six new mechanics corresponding to further shape theories

NASA Astrophysics Data System (ADS)

Anderson, Edward

2016-02-01

In this paper, suite of relational notions of shape are presented at the level of configuration space geometry, with corresponding new theories of shape mechanics and shape statistics. These further generalize two quite well known examples: (i) Kendall’s (metric) shape space with his shape statistics and Barbour’s mechanics thereupon. (ii) Leibnizian relational space alias metric scale-and-shape space to which corresponds Barbour-Bertotti mechanics. This paper’s new theories include, using the invariant and group namings, (iii) Angle alias conformal shape mechanics. (iv) Area ratio alias e shape mechanics. (v) Area alias e scale-and-shape mechanics. (iii)-(v) rest respectively on angle space, area-ratio space, and area space configuration spaces. Probability and statistics applications are also pointed to in outline. (vi) Various supersymmetric counterparts of (i)-(v) are considered. Since supergravity differs considerably from GR-based conceptions of background independence, some of the new supersymmetric shape mechanics are compared with both. These reveal compatibility between supersymmetry and GR-based conceptions of background independence, at least within these simpler model arenas.

Designing a Specialist Post-Graduate Qualification and Continuing Professional Development Structure for the Health Librarian Workforce of the Future

ERIC Educational Resources Information Center

Ritchie, Ann; Hallam, Gillian; Hamill, C.; Lewis, S.; Foti, M.; O'Connor, P.; Clark, C.

2010-01-01

Through a grant received from the Australian Library and Information Association (ALIA), Health Libraries Australia (HLA) is conducting a twelve-month research project with the goal of developing a system-wide approach to education for the future health librarianship workforce. The research has two main aims: to determine the future skills,…

VizieR Online Data Catalog: Cataclysmic Binaries, LMXBs, and related objects (Ritter+, 2003)

NASA Astrophysics Data System (ADS)

Ritter, H.; Kolb, U.

2004-03-01

Cataclysmic Binaries are semi-detached binaries consisting of a white dwarf or a white dwarf precursor primary and a low-mass secondary which is filling its critical Roche lobe. The secondary is not necessarily unevolved, it may even be a highly evolved star as for example in the case of the AM CVn-type stars. Low-Mass X-Ray Binaries are semi-detached binaries consisting of either a neutron star or a black hole primary, and a low-mass secondary which is filling its critical Roche lobe. Related Objects are detached binaries consisting of either a white dwarf or a white dwarf precursor primary and of a low-mass secondary. The secondary may also be a highly evolved star. The catalogue lists coordinates, apparent magnitudes, orbital parameters, stellar parameters of the components and other characteristic properties of 522 cataclysmic binaries, 75 low-mass X-ray binaries and 117 related objects with known or suspected orbital periods together with a comprehensive selection of the relevant recent literature. In addition the catalogue contains a list of references to published finding charts for 695 of the 714 objects. A cross-reference list of alias object designations concludes the catalogue. Literature published before 31 December 2003 has, as far as possible, been taken into account. This catalogue supersedes the 5th edition (catalogue ) and the updated lists by Ritter and Kolb (1995; catalogue ) (1998; catalogue ). (10 data files).

VizieR Online Data Catalog: Cataclysmic Binaries, LMXBs, and related objects (Ritter+, 2003)

NASA Astrophysics Data System (ADS)

Ritter, H.; Kolb, U.

2005-03-01

Cataclysmic Binaries are semi-detached binaries consisting of a white dwarf or a white dwarf precursor primary and a low-mass secondary which is filling its critical Roche lobe. The secondary is not necessarily unevolved, it may even be a highly evolved star as for example in the case of the AM CVn-type stars. Low-Mass X-Ray Binaries are semi-detached binaries consisting of either a neutron star or a black hole primary, and a low-mass secondary which is filling its critical Roche lobe. Related Objects are detached binaries consisting of either a white dwarf or a white dwarf precursor primary and of a low-mass secondary. The secondary may also be a highly evolved star. The catalogue lists coordinates, apparent magnitudes, orbital parameters, stellar parameters of the components and other characteristic properties of 572 cataclysmic binaries, 80 low-mass X-ray binaries and 142 related objects with known or suspected orbital periods together with a comprehensive selection of the relevant recent literature. In addition the catalogue contains a list of references to published finding charts for 761 of the 794 objects. A cross-reference list of alias object designations concludes the catalogue. Literature published before 31 December 2004 has, as far as possible, been taken into account. This catalogue supersedes the 5th edition (catalogue ) and the updated lists by Ritter and Kolb (1995; catalogue ) (1998; catalogue ). (10 data files).

Chemical Alias: An Engaging Way to Examine Nomenclature

ERIC Educational Resources Information Center

Kurushkin, Mikhail; Mikhaylenko, Maria

2015-01-01

An educational card game, "Chemical Alias," has been developed as an alternative method of reviewing students' knowledge of nomenclature. In contrast to conventional tests, this highly competitive activity is a fun and effective way to examine and reinforce nomenclature. The students play in pairs, using Clark's famous spiral arrangement…

Arachne User Guide. Version 1.2.

DTIC Science & Technology

1980-04-01

Arachne is an experimental operating system for controlling a network of microcomputers. It is currently implemented on a network of five Digital Equipment...ex- ception to be raised. 4.1 Alias ( Libary Routine) int alias(fslink,fnamel,fname2) char *fnamel, *fname2; The new name "fname2" is associated with

76 FR 4936 - Certain Silicon Microphone Packages and Products Containing the Same; Notice of Commission...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

... constructions, and based substantially on those claim constructions argued, inter alia, that the prior art did... ALJ rejected, and made, inter alia, noninfringement arguments based on disputed claim constructions... on the construction of the term ``attached'' in claims 1 and 7 of the '089 patent. The only dispute...

Analysis-Based Verification: A Programmer-Oriented Approach to the Assurance of Mechanical Program Properties

DTIC Science & Technology

2010-05-27

programming language, threads can only communicate through fields and this assertion prohibits an alias to the object under construction from being writ- ten...1.9. We call this type of reporting “compiler-like” in the sense that the descriptive message output by the tool has to communicate the semantics of...way to communicate a “need” for further annotation to the tool user because a precise expression of both the location and content of the needed

Airborne Laser Infrared Absorption Spectrometer (ALIAS-II) for in situ Atmospheric Measurements of N(sub 2)0, CH(sub 4), CO, HCl, and NO(sub 2) from Balloon or RPA Platforms

NASA Technical Reports Server (NTRS)

Scott, D.; Herman, R.; Webster, C.; May, R.; Flesch, G.; Moyer, E.

1998-01-01

The Airborne Laser Infrared Absorption Spectrometer II (ALIAS-II) is a lightweight, high-resolution (0.0003 cm-1), scanning, mid-infrared absorption spectrometer based on cooled (80 K) lead-salt tunable diode laser sources.

The Reasons for the Reluctance of Princess Alia University College Students' from Practicing Sports Activities

ERIC Educational Resources Information Center

Odat, Jebril

2015-01-01

This study aimed at investigating the reasons lying behind the reluctance of participation in sport activities among Alia Princess College female students, using descriptive approach. The population of the study consisted of (2000) female students, whereas the sample was of (200) students. They were randomly selected and a questionnaire of 31…

ALIA 2000. Capitalising on Knowledge: The Information Profession in the 21st Century (Canberra, Australia, October 23-26, 2000).

ERIC Educational Resources Information Center

Australian Library and Information Association, Deakin.

This proceeding of the Australian Library and Information Association (ALIA) 2000 conference contains 64 papers presented at the main conference and 12 papers presented at the fringe conference. Topics covered include: the 21st century information environment; user perspectives of the future of the Internet; the user interface; public libraries in…

Motives of Students' Joining Master Program at Princess Alia University College/Al Balqa Applied University

ERIC Educational Resources Information Center

Al Habahbeh, Abdullah Eid

2014-01-01

This study aimed at knowing the motives of students' joining master program at Princess Alia University College/Al Balqa Applied University by the graduate students and a degree of their importance and succession, and to know whether these motives differed according to the variables of gender, specialization, age, and marital status. To achieve…

VizieR Online Data Catalog: Cataclysmic Binaries, LMXBs, and related objects (Ritter+, 2003)

NASA Astrophysics Data System (ADS)

Ritter, H.; Kolb, U.

2003-08-01

Cataclysmic Binaries are semi-detached binaries consisting of a white dwarf or a white dwarf precursor primary and a low-mass secondary which is filling its critical Roche lobe. The secondary is not necessarily unevolved, it may even be a highly evolved star as for example in the case of the AM CVn-type stars. Low-Mass X-Ray Binaries are semi-detached binaries consisting of either a neutron star or a black hole primary, and a low-mass secondary which is filling its critical Roche lobe. Related Objects are detached binaries consisting of either a white dwarf or a white dwarf precursor primary and of a low-mass secondary. The secondary may also be a highly evolved star. The catalogue lists coordinates, apparent magnitudes, orbital parameters, stellar parameters of the components and other characteristic properties of 501 cataclysmic binaries, 74 low-mass X-ray binaries and 114 related objects with known or suspected orbital periods together with a comprehensive selection of the relevant recent literature. In addition the catalogue contains a list of references to published finding charts for 651 of the 689 objects. A cross-reference list of alias object designations concludes the catalogue. Literature published before 30 June 2003 has, as far as possible, been taken into account. This catalogue supersedes the 5th edition (catalogue ) and the updated lists by Ritter and Kolb (1995; catalogue ) (1998; catalogue ). (10 data files).

Polymers for 3D Printing and Customized Additive Manufacturing.

PubMed

Ligon, Samuel Clark; Liska, Robert; Stampfl, Jürgen; Gurr, Matthias; Mülhaupt, Rolf

2017-08-09

Additive manufacturing (AM) alias 3D printing translates computer-aided design (CAD) virtual 3D models into physical objects. By digital slicing of CAD, 3D scan, or tomography data, AM builds objects layer by layer without the need for molds or machining. AM enables decentralized fabrication of customized objects on demand by exploiting digital information storage and retrieval via the Internet. The ongoing transition from rapid prototyping to rapid manufacturing prompts new challenges for mechanical engineers and materials scientists alike. Because polymers are by far the most utilized class of materials for AM, this Review focuses on polymer processing and the development of polymers and advanced polymer systems specifically for AM. AM techniques covered include vat photopolymerization (stereolithography), powder bed fusion (SLS), material and binder jetting (inkjet and aerosol 3D printing), sheet lamination (LOM), extrusion (FDM, 3D dispensing, 3D fiber deposition, and 3D plotting), and 3D bioprinting. The range of polymers used in AM encompasses thermoplastics, thermosets, elastomers, hydrogels, functional polymers, polymer blends, composites, and biological systems. Aspects of polymer design, additives, and processing parameters as they relate to enhancing build speed and improving accuracy, functionality, surface finish, stability, mechanical properties, and porosity are addressed. Selected applications demonstrate how polymer-based AM is being exploited in lightweight engineering, architecture, food processing, optics, energy technology, dentistry, drug delivery, and personalized medicine. Unparalleled by metals and ceramics, polymer-based AM plays a key role in the emerging AM of advanced multifunctional and multimaterial systems including living biological systems as well as life-like synthetic systems.

Polymers for 3D Printing and Customized Additive Manufacturing

PubMed Central

2017-01-01

Additive manufacturing (AM) alias 3D printing translates computer-aided design (CAD) virtual 3D models into physical objects. By digital slicing of CAD, 3D scan, or tomography data, AM builds objects layer by layer without the need for molds or machining. AM enables decentralized fabrication of customized objects on demand by exploiting digital information storage and retrieval via the Internet. The ongoing transition from rapid prototyping to rapid manufacturing prompts new challenges for mechanical engineers and materials scientists alike. Because polymers are by far the most utilized class of materials for AM, this Review focuses on polymer processing and the development of polymers and advanced polymer systems specifically for AM. AM techniques covered include vat photopolymerization (stereolithography), powder bed fusion (SLS), material and binder jetting (inkjet and aerosol 3D printing), sheet lamination (LOM), extrusion (FDM, 3D dispensing, 3D fiber deposition, and 3D plotting), and 3D bioprinting. The range of polymers used in AM encompasses thermoplastics, thermosets, elastomers, hydrogels, functional polymers, polymer blends, composites, and biological systems. Aspects of polymer design, additives, and processing parameters as they relate to enhancing build speed and improving accuracy, functionality, surface finish, stability, mechanical properties, and porosity are addressed. Selected applications demonstrate how polymer-based AM is being exploited in lightweight engineering, architecture, food processing, optics, energy technology, dentistry, drug delivery, and personalized medicine. Unparalleled by metals and ceramics, polymer-based AM plays a key role in the emerging AM of advanced multifunctional and multimaterial systems including living biological systems as well as life-like synthetic systems. PMID:28756658

Runtime Speculative Software-Only Fault Tolerance

DTIC Science & Technology

2012-06-01

reliability of RSFT, a in-depth analysis on its window of vulnerability is also discussed and measured via simulated fault injection. The performance...propagation of faults through the entire program. For optimal performance, these techniques have to use herotic alias analysis to find the minimum set of...affect program output. No program source code or alias analysis is needed to analyze the fault propagation ahead of time. 2.3 Limitations of Existing

Prevalence of job-related distress and satisfaction in a nationwide cardiology setting: The IANUS - itAliaN cardiologists' Undetected distress Study.

PubMed

Majani, Giuseppina; Di Tano, Giuseppe; Giardini, Anna; De Maria, Renata; Russo, Giulia; Maestri, Roberto; Marini, Marco; Milli, Massimo; Aspromonte, Nadia

2016-08-01

Cardiologists' work distress has been seldom studied. The ItAliaN cardiologists' Undetected distress Study survey was designed to assess prevalence of work distress and satisfaction, and to gain insight into associations among these constructs and socio-demographics and job description. We invited members of our national cardiological society (Associazione Nazionale Medici Cardiologi Ospedalieri) to participate in an anonymous, self-report, exclusively web-based survey, posted on the Associazione Nazionale Medici Cardiologi Ospedalieri website. ItAliaN cardiologists' Undetected distress Study included socio-demographics, job description and a 15-item questionnaire on job-related distress and work satisfaction. Of 7393 invited cardiologists, 1064 completed the survey. Organizational problems and worries about medico-legal controversies were reported by 71% and 49% of participants, respectively; over one-third reported loss of enthusiasm, helplessness, work-life imbalance and lack of control over work. Conversely, 86% felt competent at work, 67% rewarded by the moral/human meaning of their work and 52% satisfied with their professional fulfilment. Factor analysis revealed a meaningful underlying structure including four factors: job strain, positive meaning, emotional fatigue and relational difficulties. Relational difficulties were more frequent in cardiologists working in primary-level than in secondary and tertiary care hospitals (P = 0.017 and P = 0.013, respectively). Interventional cardiologists reported higher positive meaning than those in the clinical inpatients area and outpatient diagnostic settings (P = 0.007 and P = 0.025, respectively) and lower emotional fatigue than subjects in the clinical inpatients area (P = 0.0005). Cardiologists' work distress should be interpreted integrating job-related negative aspects with a reappraisal of protective personal and relational resources, which should be fostered to promote physicians' wellbeing at the individual, collective and organizational levels.

Sampling from a Discrete Distribution While Preserving Monotonicity.

DTIC Science & Technology

1982-02-01

in a table beforehand, this procedure, known as the inverse transform method, requires n storage spaces and EX comparisons on average, which may prove...limitations that deserve attention: a. In general, the alias method does not preserve a monotone relationship between U and X as does the inverse transform method...uses the inverse transform approach but with more information computed beforehand, as in the alias method. The proposed method is not new having been

The Degree of Applying the Theoretical Frameworks of Child-Raising Specialty Courses in the Field of Training among the Female Students of Princess Alia University College

ERIC Educational Resources Information Center

Tweeikat, Mashhour Mohammad; AL-Kaddah, Muhammad Ibrahim

2014-01-01

This paper aims at studying to what extent the female students in Child Education department at Princess Alia University College manage to apply the theoretical part in field training program. The data, which is the scope of this study, consists of 42 staff members and 36 educational supervisors responsible for the program. The two researchers…

Scanning wind-vector scatterometers with two pencil beams

NASA Technical Reports Server (NTRS)

Kirimoto, T.; Moore, R. K.

1984-01-01

A scanning pencil-beam scatterometer for ocean windvector determination has potential advantages over the fan-beam systems used and proposed heretofore. The pencil beam permits use of lower transmitter power, and at the same time allows concurrent use of the reflector by a radiometer to correct for atmospheric attenuation and other radiometers for other purposes. The use of dual beams based on the same scanning reflector permits four looks at each cell on the surface, thereby improving accuracy and allowing alias removal. Simulation results for a spaceborne dual-beam scanning scatterometer with a 1-watt radiated power at an orbital altitude of 900 km is described. Two novel algorithms for removing the aliases in the windvector are described, in addition to an adaptation of the conventional maximum likelihood algorithm. The new algorithms are more effective at alias removal than the conventional one. Measurement errors for the wind speed, assuming perfect alias removal, were found to be less than 10%.

Application of the Life Cycle Analysis and the Building Information Modelling Software in the Architectural Climate Change-Oriented Design Process

NASA Astrophysics Data System (ADS)

Gradziński, Piotr

2017-10-01

Whereas World’s climate is changing (inter alia, under the influence of architecture activity), the author attempts to reorientations design practice primarily in a direction the use and adapt to the climatic conditions. Architectural Design using in early stages of the architectural Design Process of the building, among other Life Cycle Analysis (LCA) and digital analytical tools BIM (Building Information Modelling) defines the overriding requirements which the designer/architect should meet. The first part, the text characterized the architecture activity influences (by consumption, pollution, waste, etc.) and the use of building materials (embodied energy, embodied carbon, Global Warming Potential, etc.) within the meaning of the direct negative environmental impact. The second part, the paper presents the revision of the methods and analytical techniques prevent negative influences. Firstly, showing the study of the building by using the Life Cycle Analysis of the structure (e.g. materials) and functioning (e.g. energy consumptions) of the architectural object (stages: before use, use, after use). Secondly, the use of digital analytical tools for determining the benefits of running multi-faceted simulations in terms of environmental factors (exposure to light, shade, wind) directly affecting shaping the form of the building. The conclusion, author’s research results highlight the fact that indicates the possibility of building design using the above-mentioned elements (LCA, BIM) causes correction, early designs decisions in the design process of architectural form, minimizing the impact on nature, environment. The work refers directly to the architectural-environmental dimensions, orienting the design process of buildings in respect of widely comprehended climatic changes.

Metal distribution in urban soil around steel industry beside Queen Alia Airport, Jordan.

PubMed

Al-Khashman, Omar A; Shawabkeh, Reyad A

2009-12-01

The objective of this study was to assess the extent and severity of metal contamination in urban soil around Queen Alia Airport, Jordan. Thirty-two soil samples were collected around steel manufacturing plants located in the Al-Jiza area, south Jordan, around the Queen Alia Airport. The samples were obtained at two depths, 0-10 and 10-20 cm, and were analyzed by atomic absorption spectrophotometry for lead (Pb), zinc (Zn), cadmium (Cd), iron (Fe), copper (Cu) and chromium (Cr) levels. The physicochemical factors believed to affect the mobility of metals in the soil of the study area were also examined, including pH, electrical conductivity, total organic matter, calcium carbonate (CaCO(3)) content and cation exchange capacity. The high concentrations of Pb, Zn and Cd in the soil samples were found to be related to anthropogenic sources, such as the steel manufacturing plants, agriculture and traffic emissions, with the highest concentrations of these metals close to the site of the steel plants; in contrast the concentration of Cr was low in the soil sampled close to the steel plants. The metals were concentrated in the surface soil, and concentrations decreased with increasing depth, reflecting the physical properties of the soil and its alkaline pH. The mineralogical composition of the topsoil, identified by X-ray diffraction, was predominantly quartz, calcite, dolomite and minor minerals, such as gypsum and clay minerals. Metal concentrations were compared using one-way analysis of variance (ANOVA) to compute the statistical significance of the mean. The results of the ANOVA showed significant differences between sites for Pb, Cd and Cu, but no significant differences for the remaining metals tested. Factor analysis revealed that polluted soil occurs predominantly at sites around the steel plants and that there is no significant variation in the characteristics of the unpolluted soil, which are uniform in the study area.

Mapping Autonomous System’s Router Level Topology in IPv6

DTIC Science & Technology

2007-06-01

useful and is called rate limiting. Rate limiting sends enough probes to one of the alias addresses to cause the router to begin rate limiting the...network. The second key capability required was alias and anonymous resolution: if there was no method of making these functions happen then any graph...command, then port unreachable responses were received by probes through d5 to interface d13 or d5. Again, it is believed that this happened

Oblique reconstructions in tomosynthesis. II. Super-resolution

PubMed Central

Acciavatti, Raymond J.; Maidment, Andrew D. A.

2013-01-01

Purpose: In tomosynthesis, super-resolution has been demonstrated using reconstruction planes parallel to the detector. Super-resolution allows for subpixel resolution relative to the detector. The purpose of this work is to develop an analytical model that generalizes super-resolution to oblique reconstruction planes. Methods: In a digital tomosynthesis system, a sinusoidal test object is modeled along oblique angles (i.e., “pitches”) relative to the plane of the detector in a 3D divergent-beam acquisition geometry. To investigate the potential for super-resolution, the input frequency is specified to be greater than the alias frequency of the detector. Reconstructions are evaluated in an oblique plane along the extent of the object using simple backprojection (SBP) and filtered backprojection (FBP). By comparing the amplitude of the reconstruction against the attenuation coefficient of the object at various frequencies, the modulation transfer function (MTF) is calculated to determine whether modulation is within detectable limits for super-resolution. For experimental validation of super-resolution, a goniometry stand was used to orient a bar pattern phantom along various pitches relative to the breast support in a commercial digital breast tomosynthesis system. Results: Using theoretical modeling, it is shown that a single projection image cannot resolve a sine input whose frequency exceeds the detector alias frequency. The high frequency input is correctly visualized in SBP or FBP reconstruction using a slice along the pitch of the object. The Fourier transform of this reconstructed slice is maximized at the input frequency as proof that the object is resolved. Consistent with the theoretical results, experimental images of a bar pattern phantom showed super-resolution in oblique reconstructions. At various pitches, the highest frequency with detectable modulation was determined by visual inspection of the bar patterns. The dependency of the highest detectable frequency on pitch followed the same trend as the analytical model. It was demonstrated that super-resolution is not achievable if the pitch of the object approaches 90°, corresponding to the case in which the test frequency is perpendicular to the breast support. Only low frequency objects are detectable at pitches close to 90°. Conclusions: This work provides a platform for investigating super-resolution in oblique reconstructions for tomosynthesis. In breast imaging, this study should have applications in visualizing microcalcifications and other subtle signs of cancer. PMID:24320445

The Use of Ion Implantation for Materials Processing.

DTIC Science & Technology

1983-09-28

SPUTTERING ANALYSIS WITH PIXE.......................... 31 J.M. Lambert, P.A. Treado, D . Trbojevic ,2 R.G. Alias, A.R. Knudson, G.W. Reynolds and F.R...Lambert and P. . Treado I D . Trbojevic R. G. Allas and A. R. Knudson 3 G. W. Reynolds and F. R. Vozzo 4 IGeorgetown University Washington, D . C. and...D.C. 20057 and 20375 D . Trbojevic Georgetown University, Washington, D.C. 20057 R.G. Alias and A.R. Knudson Naval Research Laboratory, Washington, D.C

Protected, back-illuminated silicon photocathodes or photoanodes for water splitting tandem stacks (Conference Presentation)

NASA Astrophysics Data System (ADS)

Vesborg, Peter C.; Bae, Dowon; Seger, Brian J.; Chorkendorff, Ib; Hansen, Ole; Pedersen, Thomas; Mei, Bastian; Frydendal, Rasmus

2016-10-01

Silicon is a promising contender in the race for low-bandgap absorbers for use in a solar driven monolithic water splitting cell (PEC). However, given its role as the low-bandgap material the silicon must sit behind the corresponding high-bandgap material and as such, it will be exposed to (red) light from the dry back-side - not from the wet front side, where the electrochemistry takes place.[1,2] Depending on the configuration of the selective contacts (junctions) this may lead to compromises between high absorption and low recombination.[2,3] We discuss the tradeoffs and compare modeling results to measurements. Regardless of configuration, the wet surface of the silicon is prone to passivation or corrosion and must therefore be carefully protected in service in order to remain active. We demonstrate the use of TiO2 as an effective protection layer for both photoanodes and photocathodes in acid electrolyte [4] and NiCoOx for photoanodes in alkaline electrolyte. [3] References: [1]: B. Seger et alia, Energ. Environ. Sci., 7 (8), 2397-2413 (2014), DOI:10.1039/c4ee01335b [2]: D. Bae et alia, Energ. Environ. Sci., 8 (2), 650-660 (2015), DOI: 10.1039/c4ee03723e [3]: D. Bae et alia, submitted, (2016) [4]: B. Mei et alia, J. Phys. Chem. C., 119 (27), 15019-15027 (2015), DOI: 10.1021/acs.jpcc.5b04407

CFD analysis on effect of front windshield angle on aerodynamic drag

NASA Astrophysics Data System (ADS)

Abdellah, Essaghouri; Wang, Bo

2017-09-01

The external aerodynamics plays an important role in the design process of any automotive. The whole performance of the vehicle can be improved with the help of external aerodynamics. The aerodynamic analysis nowadays is implemented in the recent research in the automotive industry to achieve better cars in terms of design and efficiency. The major objective of the present work is to find out the effect of changing the angle between the engine hood and the front windshield on reducing the car air resistance. A full scale three dimensional (BMW 3 series) sedan car model was carried out using the ALIAS AUTOSTUDIO 2016 a NURBS modeling tool with high quality surfaces, only the external shape of the car was modeled while the interior was not modeled. The ANSYS 17.0 WORKBENCH software package was used to analyse the airflow around the external shape of the car - the solutions of Reynolds Average Navier Stokes (RANS) equations has been carried out using realizable k-epsilon turbulence model (which is perfectly suitable for the automated calculation process) for the given car domain. In this work, the boundary layer, mesh quality, and turbulent value simulation has been compared and discussed in the result section. Finally the optimal model was selected and the redesigned car was analysed to verify the results.

Three High-Tech High Seniors Join the Alia Expedition to Samoa: Science and Science Education

NASA Astrophysics Data System (ADS)

English, B.; Delaney, R.; Staudigel, D.; Staudigel, H.; Koppers, A.; Hart, S.

2005-12-01

Three high school seniors from High Tech High (HTH) participated in the ALIA expedition that explored the Samoan hot spot track through seafloor mapping, rock sampling and the study of the water column above an active submarine volcano. The primary responsibility of the HTH participants focused on outreach and education, but they also were substantively involved in all scientific aspects of the cruise. Education and outreach activities included: maintaining the cruise website,the creation of ERESE digital library resources for earth science education, live video-conferences with students half a world away in San Diego, and offering tours of the Research Vessel Kilo Moana during an open house event organized with the Samoa Department of Eduation. At this occasion, the HTH seniors shared experiences and knowledge with the visiting Samoan elementary and high school students. Science involvement of the high school seniors included deck and laboratory work, by assisting with dredging, piston coring, rock cataloguing, casting CTDs, and computer programming. Three major computer programming efforts by the HTH seniors substantively supported the outreach activities and the science operations during ALIA. (1) The development of "CustomHTMLExport", a utility that allows for the export of photographs and their metadata into web pages and digital library collection. (2) The "CruiseWatch" featureson the ALIA website (http://earthref.org/ERESE/projects/ALIA/) that displays in near - real time key shipboard data such as the location on a map, geographic coordinates, ship speed, direction and wind speed and dredging data. (3) A dredge location simulator to predict the location of the dredge with respect to the ship and the seafloor which was made necessary for the safety of dredging due to the failure of pingers that normally are used to provide critical data for the location of the dredge with respect to the seafloor. The dredge location model is based a fluid dynamics approach and on a wide range of parameters that range from the bathymetry to the drag on the wire in the water. The latter was determined empirically from the wire angle during dynamic ship/winch operations. This model proved to be highly accurate, Our involvement with the ALIA expedition gave us some exciting perspectives on how scientific research is conducted at sea and the pleasure of having actually contributed to the expedition in terms of its science and outreach and education aspects. Our learning and science activities were shared with our peers at High Tech High as well as.

Technique of semiautomatic surface reconstruction of the visible Korean human data using commercial software.

PubMed

Park, Jin Seo; Shin, Dong Sun; Chung, Min Suk; Hwang, Sung Bae; Chung, Jinoh

2007-11-01

This article describes the technique of semiautomatic surface reconstruction of anatomic structures using widely available commercial software. This technique would enable researchers to promptly and objectively perform surface reconstruction, creating three-dimensional anatomic images without any assistance from computer engineers. To develop the technique, we used data from the Visible Korean Human project, which produced digitalized photographic serial images of an entire cadaver. We selected 114 anatomic structures (skin [1], bones [32], knee joint structures [7], muscles [60], arteries [7], and nerves [7]) from the 976 anatomic images which were generated from the left lower limb of the cadaver. Using Adobe Photoshop, the selected anatomic structures in each serial image were outlined, creating a segmented image. The Photoshop files were then converted into Adobe Illustrator files to prepare isolated segmented images, so that the contours of the structure could be viewed independent of the surrounding anatomy. Using Alias Maya, these isolated segmented images were then stacked to construct a contour image. Gaps between the contour lines were filled with surfaces, and three-dimensional surface reconstruction could be visualized with Rhinoceros. Surface imperfections were then corrected to complete the three-dimensional images in Alias Maya. We believe that the three-dimensional anatomic images created by these methods will have widespread application in both medical education and research. 2007 Wiley-Liss, Inc

Theory and operation of a three-gate time-of-flight velocity analyzer

NASA Technical Reports Server (NTRS)

Martus, K. E.; Orient, O. J.; Hodges, R. R.; Chutjian, A.

1993-01-01

Theoretical considerations and test results are presented for a new-type velocity analyzer for incident fast neutral particles, positive ions, and negative ions. Velocity analysis is carried out by means of a pulsed, three-gate time-of-flight (TOF) technique capable of eliminating alias velocities (harmonics) to sixth order. In addition the design and operation are presented of a four-element ion lens system, with small spherical and chromatic aberrations, suitable for interfacing a large-diameter ion beam from the TOF section with a subsequent mass analyzer.

Design and Implementation of a Prototype Microcomputer Database Management System for the Standardization of Data Elements for the Department of Defense

DTIC Science & Technology

1990-09-01

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From Visions to Practical Policy: The Universal Design Journey in Norway. What Did We Learn? What Did We Gain? What Now?

PubMed

Lund, Einar; Bringa, Olav Rand

2016-01-01

The national policy in Norway have since the last part of the 1990-ies been organized in programs that erected actions including national authorities, municipalities, regional authorities and private enterprises. What have we gained by our national activities to mainstream inclusive and accessibility policy for persons with reduced capability through the principles of Universal Design? Have we made society accessible to everyone and prevented discrimination. Are the results visible? We can measure results on several sectors, inter alia public buildings, outdoor areas, central communication hubs, public transport and the occurrence plans for Universal Design in municipalities and regions. Through several programs and action plans the Norwegian government has developed a sectoral approach for including persons with disabilities in the society. The majority of ministries have participated in these plans. Local initiatives, local councils for disabled people, and later on municipalities and county administrations were supported by national authorities as complements to regulations and laws. In addition, guidelines and assisting funds were used. The main objective was to redefine the national policy, using better defined national goals and introducing Universal Design to replace accessibility as the basic tool. The mainstreaming of the accessibility policy, where Universal Design was included in relevant sectors and activities, was a crucial part of the strategy. The national policy was organized in programs that erected actions focusing on how to reach, inspire and include municipalities and regional authorities in their own struggle for Universal Design. Through the mainstream approach ministries have both earmarked economic transfers to their own agencies and used steering documents guide to these agencies how to implement Universal Design in their advisory services, in practicing laws and regulations and in their own planning and building activities.

Critique of the review of 'Water fluoridation for the prevention of dental caries' published by the Cochrane Collaboration in 2015.

PubMed

Rugg-Gunn, A J; Spencer, A J; Whelton, H P; Jones, C; Beal, J F; Castle, P; Cooney, P V; Johnson, J; Kelly, M P; Lennon, M A; McGinley, J; O'Mullane, D; Sgan-Cohen, H D; Sharma, P P; Thomson, W M; Woodward, S M; Zusman, S P

2016-04-01

The Cochrane Review on water fluoridation for the prevention of dental caries was published in 2015 and attracted considerable interest and comment, especially in countries with extensive water fluoridation programmes. The Review had two objectives: (i) to evaluate the effects of water fluoridation (artificial or natural) on the prevention of dental caries, and (ii) to evaluate the effects of water fluoridation (artificial or natural) on dental fluorosis. The authors concluded, inter alia, that there was very little contemporary evidence, meeting the Review's inclusion criteria, that evaluated the effectiveness of water fluoridation for the prevention of dental caries. The purpose of this critique is to examine the conduct of the above Review, and to put it into context in the wider body of evidence regarding the effectiveness of water fluoridation. While the overall conclusion that water fluoridation is effective in caries prevention agrees with previous reviews, many important public health questions could not be answered by the Review because of the restrictive criteria used to judge adequacy of study design and risk of bias. The potential benefits of using wider criteria in order to achieve a fuller understanding of the effectiveness of water fluoridation are discussed.

Sub-Nyquist Sampling and Moire-Like Waveform Distortions

NASA Technical Reports Server (NTRS)

Williams, Glenn L.

2000-01-01

Investigations of aliasing effects in digital waveform sampling have revealed the existence of a mathematical field and a pseudo-alias domain lying to the left of a "Nyquist line" in a plane defining the boundary between two domains of sampling. To the right of the line lies the classic alias domain. For signals band-limited below the Nyquist limit, displayed output may show a false modulation envelope. The effect occurs whenever the sample rate and the signal frequency are related by ratios of mutually prime integers. Belying the principal of a 10:1 sampling ratio being "good enough", this distortion easily occurs in graphed one-dimensional waveforms and two-dimensional images and occurs daily on television.

DNS load balancing in the CERN cloud

NASA Astrophysics Data System (ADS)

Reguero Naredo, Ignacio; Lobato Pardavila, Lorena

2017-10-01

Load Balancing is one of the technologies enabling deployment of large-scale applications on cloud resources. A DNS Load Balancer Daemon (LBD) has been developed at CERN as a cost-effective way to balance applications accepting DNS timing dynamics and not requiring persistence. It currently serves over 450 load-balanced aliases with two small VMs acting as master and slave. The aliases are mapped to DNS subdomains. These subdomains are managed with DDNS according to a load metric, which is collected from the alias member nodes with SNMP. During the last years, several improvements were brought to the software, for instance: support for IPv6, parallelization of the status requests, implementing the client in Python to allow for multiple aliases with differentiated states on the same machine or support for application state. The configuration of the Load Balancer is currently managed by a Puppet type. It discovers the alias member nodes and gets the alias definitions from the Ermis REST service. The Aiermis self-service GUI for the management of the LB aliases has been produced and is based on the Ermis service above that implements a form of Load Balancing as a Service (LBaaS). The Ermis REST API has authorisation based in Foreman hostgroups. The CERN DNS LBD is Open Software with Apache 2 license.

Impact of technical and technological changes on energy efficiency of production company - case study

NASA Astrophysics Data System (ADS)

Szwedzka, K.; Gruszka, J.; Szafer, P.

2016-08-01

Improving energy efficiency is one of the strategic objectives of the European Union for rational energy economy. To make efforts to improve energy efficiency have been obliged both small and large end-users. This article aims to show the possibilities of improving energy efficiency by introducing technical and technological process changes of pine lumber drying. The object of the research is process of drying lumber implemented in a production company, which is a key supplier of large furniture manufacturer. Pine lumber drying chamber consume about 45% of total electricity in sawmill. According to various sources, drying of 1m3 of lumber uses about 3060kWh and is dependent of inter alia: the drying process itself, the factors affecting the processing time and the desired output moisture content of the timber. The article proposals for changes in the process of drying lumber pine have been positively validated in the company, and as a result their energy consumption per 1 m3 of product declined by 18%.

45 CFR 1602.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Corporation in connection with the transaction of the Corporation's business and preserved by the Corporation... include, inter alia, books, magazines, or other materials acquired solely for library purposes. (h...

45 CFR 1602.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Corporation in connection with the transaction of the Corporation's business and preserved by the Corporation... include, inter alia, books, magazines, or other materials acquired solely for library purposes. (h...

12 CFR 353.3 - Reports and records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... well as alias identifiers, such as driver's license or social security numbers, addresses and telephone... transaction (which for purposes of this paragraph (a)(4) means a deposit, withdrawal, transfer between...

Data model and relational database design for the New Jersey Water-Transfer Data System (NJWaTr)

USGS Publications Warehouse

Tessler, Steven

2003-01-01

The New Jersey Water-Transfer Data System (NJWaTr) is a database design for the storage and retrieval of water-use data. NJWaTr can manage data encompassing many facets of water use, including (1) the tracking of various types of water-use activities (withdrawals, returns, transfers, distributions, consumptive-use, wastewater collection, and treatment); (2) the storage of descriptions, classifications and locations of places and organizations involved in water-use activities; (3) the storage of details about measured or estimated volumes of water associated with water-use activities; and (4) the storage of information about data sources and water resources associated with water use. In NJWaTr, each water transfer occurs unidirectionally between two site objects, and the sites and conveyances form a water network. The core entities in the NJWaTr model are site, conveyance, transfer/volume, location, and owner. Other important entities include water resource (used for withdrawals and returns), data source, permit, and alias. Multiple water-exchange estimates based on different methods or data sources can be stored for individual transfers. Storage of user-defined details is accommodated for several of the main entities. Many tables contain classification terms to facilitate the detailed description of data items and can be used for routine or custom data summarization. NJWaTr accommodates single-user and aggregate-user water-use data, can be used for large or small water-network projects, and is available as a stand-alone Microsoft? Access database. Data stored in the NJWaTr structure can be retrieved in user-defined combinations to serve visualization and analytical applications. Users can customize and extend the database, link it to other databases, or implement the design in other relational database applications.

22 CFR 303.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Peace Corps in connection with the transaction of Peace Corps' business and preserved by the Peace Corps... include, inter alia, books, magazines, or other materials acquired solely for library purpose, or that are...

22 CFR 303.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Peace Corps in connection with the transaction of Peace Corps' business and preserved by the Peace Corps... include, inter alia, books, magazines, or other materials acquired solely for library purpose, or that are...

22 CFR 303.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Peace Corps in connection with the transaction of Peace Corps' business and preserved by the Peace Corps... include, inter alia, books, magazines, or other materials acquired solely for library purpose, or that are...

Stroke: Hope through Research

MedlinePlus

... the Barthel Index. Imaging for the Diagnosis of Acute Stroke Health care professionals also use a variety ... risk population. top Ongoing Clinical Trials Albumin in Acute Ischemic Stroke (ALIAS) Trial Human serum albumin is ...

TES Carbon Monoxide Validation during the Two AVE Campaigns using the Argus and ALIAS Instruments on NASA's WB-57F

NASA Technical Reports Server (NTRS)

Lopez, Jinena P.; Luo, Ming; Christensen, Lance E.; Loewenstein, Max; Jost, Hansjurg; Webster, Christopher R.; Osterman, Greg

2008-01-01

The Aura Validation Experiment (AVE) focuses on validating Aura satellite measurements of important atmospheric trace gases using ground-based, aircraft, and balloon-borne instruments. Global satellite observations of CO from the Tropospheric Emission Spectrometer (TES) on the EOS Aura satellite have been ongoing since September 2004. This paper discusses CO validation experiments during the Oct-AVE (2004 Houston, Texas) and CR-AVE (2006 San Jose, Costa Rica) campaigns. The coincidences in location and time between the satellite observations and the available in situ profiles for some cases are not ideal. However, the CO distribution patterns in the two validation flight areas are shown to have very little variability in the aircraft and satellite . observations, thereby making them suitable for validation comparisons. TES CO profiles, which typically have a retrieval uncertainty of 10-20%, are compared with in situ CO measurements from NASA Ames Research Center's Argus instrument taken on board the WB-57F aircraft during Oct-AVE. TES CO retrievals during CR-AVE are compared with in situ measurements from Jet Propulsion Laboratory's Aircraft Laser Infrared Absorption Spectrometer (ALIAS) instrument as well as with the Argus instrument, both taken on board the WB-57F aircraft. During CR-AVE, the average overall difference between ALIAS and Argus CO was 4%, with the ALIAS measurement higher. During individual flights, 2-min time-averaged differences between the two in situ instruments had standard deviation of 14%. The TES averaging kernels and a priori constraint profiles for CO are applied to the in situ data for proper comparisons to account for the reduced vertical resolution and the influence of the a priori in the satellite-derived profile. In the TES sensitive pressure range, approx.700-200 hPa, the in situ profiles and TES profiles agree within 5-10%, less than the variability in CO distributions obtained by both TES and the aircraft instruments in the two regions. TES CO is slightly lower than in situ measurements in the Houston area (midlatitudes) and slightly higher than in situ CO measurements in the Costa Rica region (tropical).

COPYCAT; IBM OS system catalog utility routine. [IBM360,370; Assembly language

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engert, D.E.

COPYCAT is an OS utility program designed to produce an efficient system-wide catalog which may reside on many volumes. Substantial improvement in performance may also be obtained on a system with only a single catalog. First, catalog entries from many different catalogs may be redistributed to equalize the load on each catalog. Second, each individual catalog is restructured in a way designed to minimize the I/O time required for searching and updating. Redistribution and restructuring parameters are under user control. Model DSCB's for generation data groups and alias entries are also processed. Catalogs on all direct access devices, including datamore » cells, are supported. Backup copies may also be made.IBM360,370; Assembly language; OS/MVT, OS/MFT, OS/VS1 and OS/VS2 Release 1; A large region size is recommended since COPYCAT will use all of the core available to it for buffers..« less

Advanced Land Imager Assessment System

NASA Technical Reports Server (NTRS)

Chander, Gyanesh; Choate, Mike; Christopherson, Jon; Hollaren, Doug; Morfitt, Ron; Nelson, Jim; Nelson, Shar; Storey, James; Helder, Dennis; Ruggles, Tim;

Temperature-dependent ideal strength and stacking fault energy of fcc Ni: a first-principles study of shear deformation.

PubMed

Shang, S L; Wang, W Y; Wang, Y; Du, Y; Zhang, J X; Patel, A D; Liu, Z K

2012-04-18

Variations of energy, stress, and magnetic moment of fcc Ni as a response to shear deformation and the associated ideal shear strength (τ(IS)), intrinsic (γ(SF)) and unstable (γ(US)) stacking fault energies have been studied in terms of first-principles calculations under both the alias and affine shear regimes within the {111} slip plane along the <112> and <110> directions. It is found that (i) the intrinsic stacking fault energy γ(SF) is nearly independent of the shear deformation regimes used, albeit a slightly smaller value is predicted by pure shear (with relaxation) compared to the one from simple shear (without relaxation); (ii) the minimum ideal shear strength τ(IS) is obtained by pure alias shear of {111}<112>; and (iii) the dissociation of the 1/2[110] dislocation into two partial Shockley dislocations (1/6[211] + 1/6[121]) is observed under pure alias shear of {111}<110>. Based on the quasiharmonic approach from first-principles phonon calculations, the predicted γ(SF) has been extended to finite temperatures. In particular, using a proposed quasistatic approach on the basis of the predicted volume versus temperature relation, the temperature dependence of τ(IS) is also obtained. Both the γ(SF) and the τ(IS) of fcc Ni decrease with increasing temperature. The computed ideal shear strengths as well as the intrinsic and unstable stacking fault energies are in favorable accord with experiments and other predictions in the literature.

The enteral vs parenteral nutrition debate revisited.

PubMed

Thomson, Andrew

2008-01-01

Many trials and several meta-analyses have been devoted to comparing enteral with parenteral nutrition support. In this review, these studies are subjected to critical analysis with particular emphasis on their methodology and clinical relevance. Evidence is produced to suggest that the heterogeneous patient populations of the studies and the rigid approach taken to comparing different nutrition therapies inter alia render their conclusions highly questionable and of very doubtful clinical significance. An alternative approach to nutrition research is suggested in which strategies of nutrition support rather than fixed menus are compared. It is suggested that objective measures of intestinal function be evaluated more fully in patients requiring nonvolitional nutrition support, and these are briefly reviewed. In addition, a more scientific approach to evaluating the physiological effects of nutrition support, including chemical tagging and evaluation of muscle function, is recommended.

Future Facility: FAIR at GSI

NASA Astrophysics Data System (ADS)

Rosner, Guenther

2007-05-01

The Facility for Antiproton and Ion Research, FAIR, is a new particle accelerator facility to be built at the GSI site in Germany. The research at FAIR will cover a wide range of topics in nuclear and hadron physics, high density plasma and atomic physics, and applications in condensed matter physics and biology. A 1.1 km circumference double ring of rapidly cycling 100 and 300 Tm synchrotrons, will be FAIR's central accelerator system. It will be used to produce, inter alia, high intensity secondary beams of antiprotons and short-lived radioactive nuclei. A subsequent suite of cooler and storage rings will deliver heavy ion and antiproton beams of unprecedented quality. Large experiments are presently being designed by the NUSTAR, PANDA, PAX, CBM, SPARC, FLAIR, HEDgeHOB and BIOMAT collaborations.

Supplier Networks and the Importance of Information Technology: Outlook on the European Automotive Industry

NASA Astrophysics Data System (ADS)

Gil, Maria José Alvarez; Kulcsar, Borbala; Aksoy, Dilan

The trends in the automotive industry changed radically from the beginning of the 80s. Increasing competition, new systems and developments compelled the companies to re-evaluate and re-design their investments and processes, by extending their networks to other parts of the world in order to gain more market. This trend could be observed first in the Western-European countries and later in Eastern-Europe. With entering new areas the companies had to face with several difficulties coming inter alia from the decisions of supplier network and information system implementation. In our study we analyze the strategic decisions of major carmaker companies entering the Eastern-European market. Our research includes two case studies of the Hungarian automotive sector.

Sustainability Trends Reflected in the Architecture of the European Examples

NASA Astrophysics Data System (ADS)

Gumińska, Anna

2017-10-01

In modern architecture, one of the leading trends are striving to obtain the most economical energy-efficient building. Eco-development focuses on contemporary use, inter alia, the technological and material solutions that meet the conditions in most of the existing laws by using renewable energy sources. These findings apply primarily to new objects. Old, historical already existing superstructure is treated in a manner less demanding adaptation to environmental conditions, mainly on the behaviour of the aesthetic. This can be disadvantageous for these properties due to increased operating costs, and thus the loss of attractiveness. At work, an attempt was made on the basis of the analysis of the literature and documentation shoot made “in situ” possible use of latest technological developments to both the renewal of the historical buildings of the central areas of European cities through the renovation of an existing building or the emergence of subsidiary buildings while preserving the cultural values, aesthetic or symbolic objects, the environment. Analyzed examples show possibilities of adapting new and upgraded properties both to your power requirements, green and to the context of the existing built environment and cultural heritage.

A satellite-based radar wind sensor

NASA Technical Reports Server (NTRS)

Xin, Weizhuang

1991-01-01

The objective is to investigate the application of Doppler radar systems for global wind measurement. A model of the satellite-based radar wind sounder (RAWS) is discussed, and many critical problems in the designing process, such as the antenna scan pattern, tracking the Doppler shift caused by satellite motion, and backscattering of radar signals from different types of clouds, are discussed along with their computer simulations. In addition, algorithms for measuring mean frequency of radar echoes, such as the Fast Fourier Transform (FFT) estimator, the covariance estimator, and the estimators based on autoregressive models, are discussed. Monte Carlo computer simulations were used to compare the performance of these algorithms. Anti-alias methods are discussed for the FFT and the autoregressive methods. Several algorithms for reducing radar ambiguity were studied, such as random phase coding methods and staggered pulse repitition frequncy (PRF) methods. Computer simulations showed that these methods are not applicable to the RAWS because of the broad spectral widths of the radar echoes from clouds. A waveform modulation method using the concept of spread spectrum and correlation detection was developed to solve the radar ambiguity. Radar ambiguity functions were used to analyze the effective signal-to-noise ratios for the waveform modulation method. The results showed that, with suitable bandwidth product and modulation of the waveform, this method can achieve the desired maximum range and maximum frequency of the radar system.

Passive treatment of wastewater and contaminated groundwater

DOEpatents

Phifer, Mark A.; Sappington, Frank C.; Millings, Margaret R.; Turick, Charles E.; McKinsey, Pamela C.

2007-11-06

A bioremediation system using inorganic oxide-reducing microbial consortia for the treatment of, inter alia coal mine and coal yard runoff uses a containment vessel for contaminated water and a second, floating phase for nutrients. Biodegradable oils are preferred nutrients.

Report: Congressionally Requested Inquiry Into the EPA’s Use of Private and Alias Email Accounts

EPA Pesticide Factsheets

Report #13-P-0433, September 26, 2013. We found no evidence that the EPA used, promoted or encouraged the use of private “non-governmental” email accounts to circumvent records management responsibilities

Passive treatment of wastewater and contaminated groundwater

DOEpatents

Phifer, Mark A.; Sappington, Frank C.; Millings, Margaret R.; Turick, Charles E.; McKinsey, Pamela C.

2006-12-12

A bioremediation system using inorganic oxide-reducing microbial consortia for the treatment of, inter alia coal mine and coal yard runoff uses a containment vessel for contaminated water and a second, floating phase for nutrients. Biodegradable oils are preferred nutrients.

A Petrogenetic Evaluation of Clinopyroxene-hosted Melt Inclusions from an Enriched Submarine Lava of the Samoan Hotspot Track: A Phase Equilibria and Diffusion Modeling Study

NASA Astrophysics Data System (ADS)

Adams, J.; Spera, F. J.; Jackson, M. G.; Schmidt, J.

2017-12-01

The Samoan hotspot track hosts lavas that are representative of the Enriched Mantle II (EMII) geochemical signature, long thought to result from incorporation of recycled upper continental crust. Silicic (66-69 wt% SiO2) clinopyroxene (cpx)-hosted melt inclusions (MI) from isotopically enriched lavas from Samoa provide a window into their petrogenetic evolution. Enriched Samoan submarine lava, ALIA-115-18, from Savai'i Island, Samoa contains clinopyroxene (cpx) antecrysts that host uniformly trachydacitic MI's. The cpx's are more radiogenic (87Sr/86Sr=0.720232-0.720830) than the host whole rock (WR) (87Sr/86Sr=0.718592) providing evidence of cpx antecryst-WR disequilibrium (Jackson et al., 2007, 2009). Phase equilibria calculations using the Magma Chamber Simulator (Bohrson et al., 2014) have corroborated a lack of relationship by fractional crystallization (FC) between the antecrysts and WR composition as well as the cpx's and MI's. Cpx thermobarometry reveals cpx antecryst-WR disequilibrium is not a pressure effect but rather reflects cpx crystallization from a more magnesian parental melt (similar to the most mafic WR of the Samoan submarine lavas; SiO2=49 wt%, MgO=9 wt%), different than the ALIA-115-18 WR. The cpx antecrysts (Mg#72-86), and the rest of the antecryst population show a crystallization range of 1-5 kbar. Cpx groundmass phenocrysts (Mg#70-75) are consistent with ALIA-115-18 WR (SiO2=55 wt%, MgO=5 wt%) composition by FC in the 1-5 kbar range. The more mafic parent may represent the magma that mixed with evolved magmas, giving rise to radiogenic ALIA-115-18, and possibly the silicic MI's. Thus, studying the petrogenesis of the MI's is essential to understanding the evolution of EMII. Many cpx antecrysts with MI's are characterized by compositional halos; transects across the halos exhibit major and trace element gradients. Modeling of diffusive exchange (Cottrell et al., 2002) between the MI's and their host lavas, mediated by diffusion through cpx, allows one to constrain post-entrapment timescales. Preliminary results show distinct gradients in Al, Ti, Si, Cr, Sr, Zr, and the REEs. These elements cover a wide range of diffusivities and partition coefficients enabling a detailed timescale study of post-entrapment MI evolution and the petrogenesis of the Samoan lava suite.

Analysis of post-tensioned girders structural behaviour using continuous temperature and strain monitoring

NASA Astrophysics Data System (ADS)

Bednarski, Ł.; Sieńko, R.; Howiacki, T.

2017-10-01

This article presents the possibility of using structural health monitoring system data for the analysis of structure’s operation during its life cycle. Within the specific case study it was proved, that continuous, automatic and long term monitoring of selected physical quantities such as strains and temperatures, can significantly improve the assessment of technical condition by identifying hazardous phenomena. In this work the analysis of structural behaviour of post-tensioned girders within the roofing of sport halls in Cracow, Poland, was performed based on measurement results and verified by numerical model carried out in SOFiSTiK software. Thanks to the possibility of performing calculations in real time and informing the manager of the object about abnormalities it is possible to manage the structure in effective way by, inter alia, planning the renovations or supporting decisions about snow removal.

Morphology of Submarine Canyons in the Palomares Margin (East of Alboran Sea, western Mediterranean)

NASA Astrophysics Data System (ADS)

Perez-Hernandez, S.; Comas, M. C.; Escutia, C.

2009-04-01

Morphological analysis on the Palomares Margin has been done using high-resolution swath bathymetry data collected during the MARSIBAL-06 (2006) cruise on board of the R/V BIO Hespérides. Complemented with data from GEBCO 2000 and Ifremer (Medimap Group, 2007) the data-set provides the first complete bathymetric mosaic of the Palomares Margin. The bathymetric mosaic allows to study the physiographic provinces of the Palomares Margin and to conduct, for the first time, a detailed morphological analysis of the two main sediment-transfer conduits: the Gata and the Alias-Almanzora Canyons. The Gata Canyon extends for 64km from the outer shelf to the base of the slope with a general W-E direction. A tributary system of canyons originates at the shelf break and continues on the slope until they merge at 1230m water depth. The walls of the canyons are characterized by repeated slides. Perpendicular profiles to the Canyon pathway reveal gentle transversal "V" asymmetrical shapes with a marked axial incision on the canyon floor (highs between 65 to 103m in the southern flank, and between 30-90m in the northern flank ). The transition from an erosional canyon to a deposition channel is located at 2100m water depth, and is characterized by trapezoidal shapes on transversal profiles accompanied of lower relieves (40-65m). At the mouth of the canyon-channel system no sedimentary lobes are observed. The Alias-Almanzora canyon (73km long and preferential direction W-E) is located North of the Gata Canyon and extends from the continental shelf to the base of the slope. A tributary system to the Alias- Almanzora canyon-head locates less than 150m from the coast, facing a fluvial drainage system onland. Proximal tributary canyons and gullies feed the main canyon until it merges in the continental slope at 1516m water depth. The tributary system exhibits a marked "V" shape in transverse profiles and marked axial incisions. Down slope, transversal profiles have trapezoidal shapes. Longitudinal profiles show convex-up sections along the tributary system and concave-up sections from the merge in the main canyon down slope. The transition from an erosional canyon to a depositional channel is located at 2100m water depth. The mouth of the Alias-Almanzora Canyon-channel system is characterized by distributaries channels and lobated features. Morphological analyses from these Canyons indicate they have different origin and evolution. The connection of the Alias-Almanzora Canyon to a fluvial drainage system offshore suggests the canyon formed by erosion of the continental shelf edge during sea-level low stand periods, when entrapment of sediment on deltas and reduced sediment transport through submarine canyons occurred. The Gata Canyon has instead developed by head wards erosion and gravitational instabilities. Both canyon systems are highly influenced by recent tectonics, and structural trends influence their location and changes in pathways. Contribution from Projects SAGAS CTM2005-08071-03-01 and TOPO-IBERIA CSD2006-00041 (R & D National Plan of the Ministry of Science and Technology and FEDER funding, Spain).

Corporatised Leadership in English Schools

ERIC Educational Resources Information Center

Courtney, Steven J.

2015-01-01

Corporatised leadership in schools in England is being promoted through new actors and new types of school, these latter with corporate structures, values, regulatory freedoms and contractual arrangements with staff. Corporatised leadership is characterised "inter alia" by the promotion of the interests of business through the…

Aliased tidal errors in TOPEX/POSEIDON sea surface height data

NASA Technical Reports Server (NTRS)

Schlax, Michael G.; Chelton, Dudley B.

1994-01-01

Alias periods and wavelengths for the M(sub 2, S(sub 2), N(sub 2), K(sub 1), O(sub 1), and P(sub 1) tidal constituents are calculated for TOPEX/POSEIDON. Alias wavelenghts calculated in previous studies are shown to be in error, and a correct method is presented. With the exception of the K(sub 1) constituent, all of these tidal aliases for TOPEX/POSEIDON have periods shorter than 90 days and are likely to be confounded with long-period sea surface height signals associated with real ocean processes. In particular, the correspondence between the periods and wavelengths of the M(sub 2) alias and annual baroclinic Rossby waves that plagued Geosat sea surface height data is avoided. The potential for aliasing residual tidal errors in smoothed estimates of sea surface height is calculated for the six tidal constituents. The potential for aliasing the lunar tidal constituents M(sub 2), N(sub 2) and O(sub 1) fluctuates with latitude and is different for estimates made at the crossovers of ascending and descending ground tracks than for estimates at points midway between crossovers. The potential for aliasing the solar tidal constituents S(sub 2), K(sub 1) and P(sub 1) varies smoothly with latitude. S(sub 2) is strongly aliased for latitudes within 50 degress of the equator, while K(sub 1) and P(sub 1) are only weakly aliased in that range. A weighted least squares method for estimating and removing residual tidal errors from TOPEX/POSEIDON sea surface height data is presented. A clear understanding of the nature of aliased tidal error in TOPEX/POSEIDON data aids the unambiguous identification of real propagating sea surface height signals. Unequivocal evidence of annual period, westward propagating waves in the North Atlantic is presented.

78 FR 52553 - Privacy Act of 1974; Department of Homeland Security/ALL-035 Common Entity Index Prototype System...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

... data elements: Full Name; Alias(es); Gender; Date of Birth; Country of Birth; Country of Citizenship... locked drawer behind a locked door. The records may be stored on magnetic disc, tape, or digital media...

NNDC Databases

Science.gov Websites

radiation. It includes an interactive chart of nuclides and a level plotting tool. XUNDL Experimental Unevaluated Nuclear Data List Experimental nuclear structure and decay data, covering more than 2,500 recent parameters* Retrieved information CSISRS alias EXFOR Nuclear reaction experimental data Experimental nuclear

75 FR 24394 - Somalia Sanctions Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-05

... reference books, photocopies, credit reports, transcripts of statements, registered mail, insurance... alia, the International Emergency Economic Powers Act (50 U.S.C. 1701- 1706), the National Emergencies... section. Note 2 to Sec. 551.201: Section 203 of the International Emergency Economic Powers Act (50 U.S.C...

Primitives for Active Internet Topology Mapping: Toward High-Frequency Characterization

DTIC Science & Technology

2010-11-03

that a tension exists between the two conflict- ing goals of reducing probing traffic and capturing dynamic forwarding paths. Many networks deploy...perform alias resolution to future work. Acknowledgments The authors would like to thank Young Hyun, k. claffy and CAIDA for measurement

Transit Time Flowmetry in Coronary Artery Bypass Grafting-experience at Queen Alia Heart Institute, Jordan

PubMed Central

Harahsheh, Basel

2012-01-01

Objectives To assess the results of transit time flowmetry (TTF) on a consecutive group of coronary artery bypass grafting (CABG) patients at Queen Alia Heart Institute. Methods Intraoperative flow measurements of a consecutive group of 436 CABG patients. The flow pattern for each coronary artery system was assessed including mean flows, pulsatility index (PI) and the need for revision. Results A total of 1394 grafts in 436 patients were assessed (3.2 grafts per patient), wherein 100 grafts showed inadequate flowmetry results (7.2%); most of which were in the circumflex and right coronary artery systems with a percentage of 9.4% and the least in the LAD system with a percentage of 4.4%. The mean flow of grafts to the LAD system was 33.4±5.3 mL/min with a PI of 2.4±0.4; while the mean for grafts to the circumflex artery system was 35.1±7.2 mL/min with a PI of 3.5±0.7. The mean for the right coronary artery was 38.4±5.9 mL/min with a PI of 2.6±0.6. Revisions occurred in five patients (1.1%). Suboptimal grafts to the LAD system exhibited a flow of 14.1±7.4 mL/min with a PI of 6.9±1.7. While for the circumflex system a flow of 5.5±3.6 mL/min was reported with a PI of 10.4±7.8; and for the right coronary system a flow of 7.2±5.3 mL/min with a PI of 9.1±5.7 was reported. Conclusion Grafts to the LAD system showed the best flowmetry results compared to grafts to the circumflex and right coronary systems. A proportion of poor grafts were revised. PMID:23226818

Academic Self-Handicapping and Achievement: A Meta-Analysis

ERIC Educational Resources Information Center

Schwinger, Malte; Wirthwein, Linda; Lemmer, Gunnar; Steinmayr, Ricarda

2014-01-01

Self-handicapping represents a frequently used strategy for regulating the threat to self-esteem elicited by the fear of failing in academic achievement settings. Several studies have documented negative associations between self-handicapping and different educational outcomes, inter alia academic achievement. However, studies on the relation…

76 FR 38002 - Western Balkans Stabilization Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

..., notary and protest fees, and charges for reference books, photocopies, credit reports, transcripts of... of, inter alia, the International Emergency Economic Powers Act (50 U.S.C. 1701-1706) (``IEEPA'') and.... Subpart D--Interpretations 588.401 Reference to amended sections. 588.402 Effect of amendment. 588.403...

Thoughts on a Pedagogy OF Complexity

ERIC Educational Resources Information Center

Byrne, David

2014-01-01

There is now a developed and extensive literature on the implications of the "complexity frame of reference" (Castellani & Hafferty, 2009) for education in general and pedagogy in particular. This includes a wide range of interesting contributions which consider how complexity can inform, inter alia, research on educational systems…

Polish Terms for "Blue" in the Perspective of Vantage Theory

ERIC Educational Resources Information Center

Stanulewicz, Danuta

2010-01-01

The Polish set of terms for blue includes, inter alia, the following adjectives: "niebieski" "blue", "blekitny" "(sky) blue", "granatowy" "navy blue", "lazurowy" "azure", "modry" "(intense) blue" and "siny" "(grey) violet-blue". The adjective "niebieski" is the basic term; however, it shares some of its functions with "blekitny", which is…

University as Regional Development Agent: A Counterfactual Analysis of an African University

ERIC Educational Resources Information Center

Fongwa, Samuel N.; Wangenge-Ouma, Gerald

2015-01-01

The contribution of universities to regional development has in the last few decades gained significant currency. Inter alia, this contribution has been through steered national, regional, and institutional policies aimed at enhancing national development, good governance, human capital creation and innovation in an increasing knowledge-dependent…

76 FR 75950 - Hazardous Materials: Emergency Restriction/Prohibition Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

.... This Order is issued to Rainbow of Hope, Strategic Sciences, Inc., Realm Industries AKA Realm Catalyst... company of Rainbow of Hope. This explosion was also linked to TyLar. In light of these facts, PHMSA... of Hope, Strategic Sciences, Inc., Realm Industries (Realm Catalyst, Inc.), any other alias or...

ALI--A Digital Archive of DAISY Books

ERIC Educational Resources Information Center

Forsberg, Asa

2007-01-01

ALI is a project to develop an archive for talking books produced by the Swedish universities. The universities produce talking books from the mandatory literature for students with reading disabilities, including mostly journal articles, book chapters and texts written by teachers. The project group consists of librarians and co-ordinators for…

Evaluation of Holographic Technology in Close Air Support Mission Planning and Execution

DTIC Science & Technology

2008-03-18

Figures Figure 1: 2D representation of 3D hologram of Baghdad area using 1-meter resolution LIDAR data...Alias Maya Software................................................................................................. 11 Figure 3: Suburban...and light detection and ranging ( LIDAR ) sensors for several geographic areas was performed in parallel with formulation of the approach

77 FR 67276 - Yemen Sanctions Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

... reference books, photocopies, credit reports, transcripts of statements, registered mail, insurance... authority of, inter alia, the International Emergency Economic Powers Act (50 U.S.C. 1701 et seq.) and the... International Emergency Economic Powers Act (50 U.S.C. 1701-1706), in Section 203 (50 U.S.C. 1702), authorizes...

22 CFR 8.11 - Records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Records. 8.11 Section 8.11 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.11 Records. (a) The records of an advisory... committee, and are maintained by the office responsible for the committee. Such records are inter alia...

22 CFR 8.11 - Records.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Records. 8.11 Section 8.11 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.11 Records. (a) The records of an advisory... committee, and are maintained by the office responsible for the committee. Such records are inter alia...

Purine inhibitors of protein kinases, G proteins and polymerases

DOEpatents

Gray, Nathanael S.; Schultz, Peter; Kim, Sung-Hou; Meijer, Laurent

2001-07-03

The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

Internationalization of U.K. University Business Schools: A Survey of Current Practice

ERIC Educational Resources Information Center

Bennett, Roger; Kane, Suzanne

2011-01-01

A questionnaire was sent to the heads of internationalization in the business schools of all U.K. universities. Sixty-five replies were received. The document covered, inter alia, the internationalization activities undertaken by the respondents' schools, the intensities with which internationalization had been implemented, motives for…

For All of Us? A Report on the 12th National Cataloguing Conference, Canberra, 1997.

ERIC Educational Resources Information Center

Naun, Chew Chiat

1997-01-01

Provides an overview of the 1997 national cataloging conference of the Australian Library and Information Association (ALIA). Topics include innovation and enervation, cataloging skills for electronic documents, the Anglo-American Cataloging Rules, content versus carrier, issues related to seriality, networking, human resource management, career…

78 FR 8220 - Actions Taken Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Actions Taken Pursuant to Executive Order 13382 ACTION: Notice. SUMMARY: The Treasury Department's Office of Foreign Assets Control (``OFAC'') is announcing an update to the entry of an entity on OFAC's SDN List by adding an alias to the entity...

Wanted: Schoolyard Plants.

ERIC Educational Resources Information Center

Callison, Priscilla L.; Wright, Emmett L.

1992-01-01

Describes an activity for studying weeds in grades four through nine. "Wanted" posters are prepared with the scientific name of a common weed and a few identifying features. Students find the plant, give it an "alias" or common name, and then draw the "wanted" picture. Presents six wanted posters and describes expansion lessons and follow-up…

The analysis of selected orientation methods of architectural objects' scans

NASA Astrophysics Data System (ADS)

Markiewicz, Jakub S.; Kajdewicz, Irmina; Zawieska, Dorota

2015-05-01

The terrestrial laser scanning is commonly used in different areas, inter alia in modelling architectural objects. One of the most important part of TLS data processing is scans registration. It significantly affects the accuracy of generation of high resolution photogrammetric documentation. This process is time consuming, especially in case of a large number of scans. It is mostly based on an automatic detection and a semi-automatic measurement of control points placed on the object. In case of the complicated historical buildings, sometimes it is forbidden to place survey targets on an object or it may be difficult to distribute survey targets in the optimal way. Such problems encourage the search for the new methods of scan registration which enable to eliminate the step of placing survey targets on the object. In this paper the results of target-based registration method are presented The survey targets placed on the walls of historical chambers of the Museum of King Jan III's Palace at Wilanów and on the walls of ruins of the Bishops Castle in Iłża were used for scan orientation. Several variants of orientation were performed, taking into account different placement and different number of survey marks. Afterwards, during next research works, raster images were generated from scans and the SIFT and SURF algorithms for image processing were used to automatically search for corresponding natural points. The case of utilisation of automatically identified points for TLS data orientation was analysed. The results of both methods for TLS data registration were summarized and presented in numerical and graphical forms.

Leadership of Learning and Teaching in the Creative Arts

ERIC Educational Resources Information Center

de la Harpe, Barbara; Mason, Thembi

2014-01-01

The leadership of learning and teaching (L&T) in higher education has evolved over recent years. Part of the evolutionary process has seen the rise of the appointment of Associate Deans L&T (Academic, Education, "inter alia"). Implicit in this role is the assumption by many that associate deans are responsible for leading…

75 FR 73059 - Record of Decision and Floodplain Statement of Findings for the Cushman Hydroelectric Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... license to include inter alia conditions for fish passage facilities and authorization to construct the... originally opposed Tacoma's Cultural Resource Summary Report, and cultural resource protection became a... in the MOA. The MOA includes a Treatment Plan that Tacoma must follow to protect cultural resources...

Accountability and Accreditation for Special Libraries: It Can Be Done!

ERIC Educational Resources Information Center

Glockner, Brigitte

2004-01-01

Health librarians are very familiar with the accreditation process in hospitals. In 2000 the first ALIA National Policy Congress recommended that accreditation of special libraries should be implemented. The proposed guidelines have been roughly based on the EQuIP Program of the Australian Council on Healthcare Standards. This program is…

75 FR 5614 - Privacy Act of 1974; Department of Homeland Security/ALL-025 Law Enforcement Authority in Support...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-03

...'s or entity's name; Digital photograph; Date of birth, place of birth, and age; Social security number; Duty/work address and telephone number; Alias; Race and ethnicity; Citizenship; Fingerprints; Sex... servers, magnetic disc, tape, digital media, and CD-ROM. RETRIEVABILITY: Records may be retrieved by...

Summing up the Summit

ERIC Educational Resources Information Center

Richards, Jan

2009-01-01

The President of ALIA writes about expectations for the Public Libraries Summit, and provides an account of what took place on the day of the meeting, and what has taken place since. In funding terms, the most likely areas of productive engagement with the federal government are considered to be: children, early learning and a literate Australia;…

Learning Goals and Conceptual Difficulties in Cell Metabolism--An Explorative Study of University Lecturers' Views

ERIC Educational Resources Information Center

Degerman, Mari Stadig; Tibell, Lena A. E.

2012-01-01

The rapid development and increasing inter- and multi-disciplinarity of life sciences invokes revisions of life science course curricula, recognizing ("inter alia") the need to compromise between covering specific phenomena and general processes/principles. For these reasons there have been several initiatives to standardize curricula,…

75 FR 61572 - Additional Identifying Information Associated With Persons Whose Property and Interests in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... Abuses by the Government of Iran and Taking Certain Other Actions'' AGENCY: Office of Foreign Assets... With Respect to Serious Human Rights Abuses by the Government of Iran and Taking Certain Other Actions... Government of Iran and Taking Certain Other Actions'' (the ``Order'') pursuant to, inter alia, the [[Page...

Speaking Self-Assessment: Mismatches between Learners' and Teachers' Criteria

ERIC Educational Resources Information Center

Babaii, Esmat; Taghaddomi, Shahin; Pashmforoosh, Roya

2016-01-01

Perceptual (mis)matches between teachers and learners are said to affect learning success or failure. Self-assessment, as a formative assessment tool, may, inter alia, be considered a means to minimize such mismatches. Therefore, the present study investigated the extent to which learners' assessment of their own speaking performance, before and…

How Relevant Are Library and Information Science Curricula outside Their Geographic Domain?

ERIC Educational Resources Information Center

Tam, Lawrence Wai-hong; Harvey, Ross; Mills, John

2007-01-01

Australian library and information science (LIS) courses are popular outside Australia, and Australia is a popular study destination for students in the region. This paper takes a comparative approach to attempt to determine whether ALIA (the Australian Library and Information Association)'s core curriculum for LIS education is appropriate outside…

Teaching Inorganic Photophysics and Photochemistry with Three Ruthenium(II) Polypyridyl Complexes: A Computer-Based Exercise

ERIC Educational Resources Information Center

Garino, Claudio; Terenzi, Alessio; Barone, Giampaolo; Salassa, Luca

2016-01-01

Among computational methods, DFT (density functional theory) and TD-DFT (time-dependent DFT) are widely used in research to describe, "inter alia," the optical properties of transition metal complexes. Inorganic/physical chemistry courses for undergraduate students treat such methods, but quite often only from the theoretical point of…

Super-Resolution for Color Imagery

DTIC Science & Technology

2017-09-01

separately; however, it requires performing the super-resolution computation 3 times. We transform images in the default red, green, blue (RGB) color space...chrominance components based on ARL’s alias-free image upsampling using Fourier-based windowing methods. A reverse transformation is performed on... Transformation from sRGB to CIELAB............................................... 3 Fig. 2 YCbCr mathematical coordinate transformation

Human Odometry Verifies the Symmetry Perspective on Bipedal Gaits

ERIC Educational Resources Information Center

Turvey, M. T.; Harrison, Steven J.; Frank, Till D.; Carello, Claudia

2012-01-01

Bipedal gaits have been classified on the basis of the group symmetry of the minimal network of identical differential equations (alias "cells") required to model them. Primary gaits are characterized by dihedral symmetry, whereas secondary gaits are characterized by a lower, cyclic symmetry. This fact was used in a test of human…

75 FR 61246 - Additional Identifying Information Associated With Persons Whose Property and Interests in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... 13551 of August 30, 2010, ``Blocking Property of Certain Persons With Respect to North Korea'' AGENCY... Property of Certain Persons With Respect to North Korea,'' whose property and interests in property are... Persons With Respect to North Korea'' (the ``Order'') pursuant to, inter alia, the International Emergency...

Real-Time Comprehension of Wh- Movement in Aphasia: Evidence from Eyetracking while Listening

ERIC Educational Resources Information Center

Dickey, Michael Walsh; Choy, JungWon Janet; Thompson, Cynthia, K.

2007-01-01

Sentences with non-canonical wh- movement are often difficult for individuals with agrammatic Broca's aphasia to understand (Carramazza & Zurif, 1976, inter alia). However, the explanation of this difficulty remains controversial, and little is known about how individuals with aphasia try to understand such sentences in real time. This study uses…

Prepositions in Use: Prepositions of Standard, Prepositions of Possession and Prepositions of Accompaniment

ERIC Educational Resources Information Center

AlQbailat, Naji Masned; Al-Momani, Islam M.; Almahameed, Yazan Shaker

2016-01-01

The current research paper attempted at investigating the use of prepositions of standard, prepositions of possession and prepositions of accompaniment by some Jordanian learners of English. A total of 53 Jordanian English Majors participated in the study from the department of English language at Princess Alia University College. In collecting…

15 CFR Supplement No. 4 to Part 744 - Entity List

Code of Federal Regulations, 2014 CFR

2014-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... the EAR. (See § 744.11 of the EAR). Presumption of denial 77 FR 25057, 4/27/12. Zurmat Group of... Electronic Solutions, a.k.a., the following one alias:—Mercury Group International, 380 Vansickle Rd Unit 660...

Investigating the Relationship between Iranian EFL Teachers' Autonomy and Their Neuro-Linguistic Programming

ERIC Educational Resources Information Center

Hosseinzadeh, Ehsan; Baradaran, Abdollah

2015-01-01

The present study was an attempt to investigate the relationship between English Language Teachers' autonomy and their Neuro-linguistic Programming (NLP). To this end, a group of 200 experienced English language teachers at various language schools in Tehran, inter alia, Asre Zaban Language Academy, were given two questionnaires namely Teaching…

Mutation affecting the expression of immunoglobulin variable regions in the rabbit.

PubMed

Kelus, A S; Weiss, S

1986-07-01

We have found a variant of the allotype allele a2 in the rabbit, which presumably arose by mutation, that segregates as expected for an allele at the a locus. This allele is called "ali" and the corresponding rabbit strain is called "Alicia." In heterozygous animals (ali/a1 and ali/a3) the concentration of a2 molecules is lower by a factor of 1000 than in standard a2/a2 homozygotes. In homozygous ali/ali individuals the a2 concentration varies with age--i.e., very low in young rabbits and higher in older ones--but it never reaches normal levels. The low level of a2 is compensated by increased amounts of a-negative molecules. Southern blot analysis did not reveal any gross changes in the intron between JH and C mu (joining region of immunoglobulin heavy chain and constant region of immunoglobulin mu chain) or in the number of VH gene segments encoding a locus specificities. We suggest that the ali phenotype is due to a mutation in a control element.

Mutation affecting the expression of immunoglobulin variable regions in the rabbit.

PubMed Central

Kelus, A S; Weiss, S

1986-01-01

We have found a variant of the allotype allele a2 in the rabbit, which presumably arose by mutation, that segregates as expected for an allele at the a locus. This allele is called "ali" and the corresponding rabbit strain is called "Alicia." In heterozygous animals (ali/a1 and ali/a3) the concentration of a2 molecules is lower by a factor of 1000 than in standard a2/a2 homozygotes. In homozygous ali/ali individuals the a2 concentration varies with age--i.e., very low in young rabbits and higher in older ones--but it never reaches normal levels. The low level of a2 is compensated by increased amounts of a-negative molecules. Southern blot analysis did not reveal any gross changes in the intron between JH and C mu (joining region of immunoglobulin heavy chain and constant region of immunoglobulin mu chain) or in the number of VH gene segments encoding a locus specificities. We suggest that the ali phenotype is due to a mutation in a control element. Images PMID:3014517

How does single party dominance influence civil society organisations’ engagement strategies? Exploratory analysis of participative mainstreaming in a ‘regional’ European polity

PubMed Central

2015-01-01

A raft of United Nations Treaties, European Union Directives and domestic laws oblige governments in 180 + countries to apply the Participative Democratic Model of mainstreaming equalities to public administration by involving those targeted by equality initiatives at all stages in their design and delivery. Notwithstanding Participative Democratic Model’s deeply political nature, extant work has overlooked how governing party turnover influences civil society organisations’ (CSOs) strategies. Here, this lacuna is addressed using a negative ‘extreme case study’ research design involving qualitative accounts from civil society organisations in Wales, a ‘regional’ European polity characterised by one-party dominance. The findings reveal how the absence of turnover distorts the Participative Democratic Model in relation to diverse factors including: strategic bridging, extraparliamentary politics, cognitive locks and party institutionalisation. Inter alia, the wider contribution of this analysis lies in showing the importance of turnover to effective engagement, the ‘pathologies’ associated with one-party dominance and the need for adaptive civil society strategies tailored to prevailing electoral politics and governing party turnover in liberal democracies. PMID:28596639

Polylactides in additive biomanufacturing.

PubMed

Poh, Patrina S P; Chhaya, Mohit P; Wunner, Felix M; De-Juan-Pardo, Elena M; Schilling, Arndt F; Schantz, Jan-Thorsten; van Griensven, Martijn; Hutmacher, Dietmar W

2016-12-15

New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

How does single party dominance influence civil society organisations' engagement strategies? Exploratory analysis of participative mainstreaming in a 'regional' European polity.

PubMed

Chaney, Paul

2016-04-01

A raft of United Nations Treaties, European Union Directives and domestic laws oblige governments in 180 + countries to apply the Participative Democratic Model of mainstreaming equalities to public administration by involving those targeted by equality initiatives at all stages in their design and delivery. Notwithstanding Participative Democratic Model's deeply political nature, extant work has overlooked how governing party turnover influences civil society organisations' (CSOs) strategies. Here, this lacuna is addressed using a negative 'extreme case study' research design involving qualitative accounts from civil society organisations in Wales, a 'regional' European polity characterised by one-party dominance. The findings reveal how the absence of turnover distorts the Participative Democratic Model in relation to diverse factors including: strategic bridging, extraparliamentary politics, cognitive locks and party institutionalisation. Inter alia, the wider contribution of this analysis lies in showing the importance of turnover to effective engagement, the 'pathologies' associated with one-party dominance and the need for adaptive civil society strategies tailored to prevailing electoral politics and governing party turnover in liberal democracies.

Biotechnology and genetic engineering in the new drug development. Part III. Biocatalysis, metabolic engineering and molecular modelling.

PubMed

Stryjewska, Agnieszka; Kiepura, Katarzyna; Librowski, Tadeusz; Lochyński, Stanisław

2013-01-01

Industrial biotechnology has been defined as the use and application of biotechnology for the sustainable processing and production of chemicals, materials and fuels. It makes use of biocatalysts such as microbial communities, whole-cell microorganisms or purified enzymes. In the review these processes are described. Drug design is an iterative process which begins when a chemist identifies a compound that displays an interesting biological profile and ends when both the activity profile and the chemical synthesis of the new chemical entity are optimized. Traditional approaches to drug discovery rely on a stepwise synthesis and screening program for large numbers of compounds to optimize activity profiles. Over the past ten to twenty years, scientists have used computer models of new chemical entities to help define activity profiles, geometries and relativities. This article introduces inter alia the concepts of molecular modelling and contains references for further reading.

Design of multiplier-less sharp transition width non-uniform filter banks using gravitational search algorithm

NASA Astrophysics Data System (ADS)

Bindiya T., S.; Elias, Elizabeth

2015-01-01

In this paper, multiplier-less near-perfect reconstruction tree-structured filter banks are proposed. Filters with sharp transition width are preferred in filter banks in order to reduce the aliasing between adjacent channels. When sharp transition width filters are designed as conventional finite impulse response filters, the order of the filters will become very high leading to increased complexity. The frequency response masking (FRM) method is known to result in linear-phase sharp transition width filters with low complexity. It is found that the proposed design method, which is based on FRM, gives better results compared to the earlier reported results, in terms of the number of multipliers when sharp transition width filter banks are needed. To further reduce the complexity and power consumption, the tree-structured filter bank is made totally multiplier-less by converting the continuous filter bank coefficients to finite precision coefficients in the signed power of two space. This may lead to performance degradation and calls for the use of a suitable optimisation technique. In this paper, gravitational search algorithm is proposed to be used in the design of the multiplier-less tree-structured uniform as well as non-uniform filter banks. This design method results in uniform and non-uniform filter banks which are simple, alias-free, linear phase and multiplier-less and have sharp transition width.

Exploring Students Intentions to Study Computer Science and Identifying the Differences among ICT and Programming Based Courses

ERIC Educational Resources Information Center

Giannakos, Michail N.

2014-01-01

Computer Science (CS) courses comprise both Programming and Information and Communication Technology (ICT) issues; however these two areas have substantial differences, inter alia the attitudes and beliefs of the students regarding the intended learning content. In this research, factors from the Social Cognitive Theory and Unified Theory of…

76 FR 59733 - Privacy Act of 1974, as Amended; Notice To Amend an Existing System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... name, alias, address, date of birth, social security number, blood degree, enrollment/BIA number, date... suspected or confirmed compromise there is a risk of harm to economic or property interest, identity theft or fraud, or harm to the security or integrity of this system or other systems or programs whether...

75 FR 44940 - Withdrawal of Application for Duty-Free Entry of Scientific Instruments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-30

... Entry of Scientific Instruments Applications may be examined between 8:30 A.M. and 5:00 P.M. in Room... determine, inter alia, whether instruments of equivalent scientific value, for the purposes for which the... scientific instrument. They noted that the instrument will be used at a show/demonstration. As noted in the...

76 FR 52936 - Withdrawal of Application for Duty-Free Entry of Scientific Instruments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-24

... Entry of Scientific Instruments Applications may be examined between 8:30 a.m. and 5 p.m. in Room 3720... determine, inter alia, whether instruments of equivalent scientific value, for the purposes for which the... scientific instrument. They noted that the instrument will be cleared through Customs with duty paid by the...

Rising to the Bilingual Challenge: Self-Reported Experiences of Managing Life with Two Languages

ERIC Educational Resources Information Center

Tytus, Agnieszka Ewa

2018-01-01

A recent surge of findings on bilingual cognitive advantage has attracted attention from both researchers and the media. An advantage has been demonstrated with regard to, inter alia, inhibiting, switching, monitoring and updating. However, Paap et al. argue that the advantage does not exist or is only limited to executive functioning. Both sides…

The Pluralisation of Family Life: Implications for Preschool Education

ERIC Educational Resources Information Center

Šebart, Mojca Kovac; Kuhar, Roman

2017-01-01

The article takes as its starting point the public debate about the newly proposed Family Code in Slovenia in 2009. Inter alia, the Code introduced a new, inclusive definition of the family in accordance with the contemporary pluralisation of family life. This raised a number of questions about how--if at all--various families are addressed in the…

Using Technology for Teaching Arabic Language Grammar

ERIC Educational Resources Information Center

Arrabtah, Adel; Nusour, Tayseer

2012-01-01

This study investigates the effect of using technology such as CD-ROM, computers, and internet to teach Arabic language grammar to students at Princess Alia University College at Al-Balqa University. The sample of the study consisted of 122 third year female students; (64) for the experimental group and (58) for the control group. The subjects of…

76 FR 54202 - Honey From Argentina: Preliminary Results of Antidumping Duty New Shipper Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

... its responses to sections B and C (BQR and CQR, respectively), and Appendix VIII (customer-specific... ``particular market situation'' questionnaire on June 29, 2011, and, in combination with its U.S. customer... therefore bona fide, the Department considers, inter alia, such factors as: (1) The timing of the sale; (2...

X-ray characterization of solid small molecule organic materials

DOEpatents

Billinge, Simon; Shankland, Kenneth; Shankland, Norman; Florence, Alastair

2014-06-10

The present invention provides, inter alia, methods of characterizing a small molecule organic material, e.g., a drug or a drug product. This method includes subjecting the solid small molecule organic material to x-ray total scattering analysis at a short wavelength, collecting data generated thereby, and mathematically transforming the data to provide a refined set of data.

77 FR 61249 - Addition of Certain Persons to the Entity List

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... certain sections of part 744 (Control Policy: End-User and End-Use Based) of the EAR. The End-user Review...; (10) Mercury Electronic Solutions, a.k.a., the following one alias: --Mercury Group International, 380 Vansickle Rd Unit 660, St. Catharines, ON L2126P7, Canada; and 127 Rue Wilson, Dollard-des-Ormeaux, Quebec...

Student Rights and Misconduct in South Africa: A Balancing Act

ERIC Educational Resources Information Center

Oosthuizen, I. J.; Rossouw, J. P.

2008-01-01

The current emergence of a human rights culture in South African educational practice has direct bearing on the approach to learner misconduct in public schools. A variety of landmark court cases are discussed here that deal with, inter alia, the school governing body's right to delegate certain powers, the occasional withdrawal of learners'…

Discourse Formation in Comparative Education. 4th, Revised Edition. Comparative Studies Series. Volume 10

ERIC Educational Resources Information Center

Schriewer, Jurgen, Ed.

2012-01-01

New theories and theory-based methodological approaches have found their way into Comparative Education--just as into Comparative Social Science more generally--in increasing number in the recent past. The essays of this volume express and critically discuss quite a range of these positions such as, inter alia, the theory of self-organizing social…

ALIAS (Acquisition and Logistics Information and Analysis System) Maintenance and Expansion Guide. Volume 1.

DTIC Science & Technology

1984-10-31

unauthorized inspection, and against whole- sale destruction by purging of its files. The usability of the data base (its "integrity") can be lost if required...screen *SMCUFS : NOLLIFOR SCARIOEE : SCNCLSE sINwU :- c~ri- E LUIMK :- $1TH4 IED~ DUml) WHILE IWINANOW MVDXFL VARIABLE %fldn=amGL(BALDISH8 AY ItuN

75 FR 57899 - Certain Stainless Steel Sheet and Strip in Coils from Italy and Mexico: Extension of Time Limits...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... antidumping duty orders on certain stainless steel sheet and strip (SSSS) in coils from, inter alia, Italy and... SSSS in coils from the following petitioners: the AK Steel Corporation; Allegheny Ludlum Corporation... substantive responses to the Notice of Initiation for all antidumping duty orders covering SSSS in coils from...

Effect of the Number of Presentations on Listener Transcriptions and Reliability in the Assessment of Speech Intelligibility in Children

ERIC Educational Resources Information Center

Lagerberg, Tove B.; Johnels, Jakob Åsberg; Hartelius, Lena; Persson, Christina

2015-01-01

Background: The assessment of intelligibility is an essential part of establishing the severity of a speech disorder. The intelligibility of a speaker is affected by a number of different variables relating, "inter alia," to the speech material, the listener and the listener task. Aims: To explore the impact of the number of…

Chlorine Chemistry of the Lower Stratosphere: Aircraft (ALIAS, ER-2) and Balloon (BLISSs) In-Situ Measurements of HC1,NO(sub 2), andN(sub 2)O for Testing Heterogeneous Chemistry

NASA Technical Reports Server (NTRS)

Webster, C.; May, R.; Jaegle, L.; Hu, H.; Scott, D.; Stimpfle, R.; Salawitch, R.; Fahey, D.; Woodbridge, E.; Proffitt, M.;

Attitudes toward Rape and Victims of Rape: A Test of the Feminist Theory in Ghana

ERIC Educational Resources Information Center

Boakye, Kofi E.

2009-01-01

This study explores the usefulness of the feminist theory in explaining attitudes toward rape and victims of rape in Ghana. The feminist theory of rape posits, inter alia, that patriarchy and gender inequality are major factors in the aetiology of rape and attitudes toward rape and that underlying patriarchy and gender inequality are gender…

Reports on Some Salient Topics and/or Issues in Educational Psychology, Measurement and Research as Presented by Doctoral Students. A Seminar.

ERIC Educational Resources Information Center

Goolsby, Thomas M., Jr., Comp.

Papers are presented that resulted from a doctoral seminar in the Department of Educational Psychology, Measurement and Research at the University of Georgia. Integration-desegregation, ethics, behavior modification, and accountability are the general areas treated. The papers are: (1) "Segregation--Alias: 'Special Education'" by Margaret C.…

Purine inhibitors of protein kinases, G proteins and polymerases

DOEpatents

Gray, Nathanael S.; Schultz, Peter; Kim, Sung-Hou; Meijer, Laurent

2004-10-12

The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

76 FR 24875 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

...: 3060-1113. Title: Commercial Mobile Alert System (CMAS). Form No.: N/A. Type of Review: Revision of a..., Alert and Response Network (``WARN'') Act, including inter alia, a requirement that within 30 days of... the Commission indicating whether or not it intends to transmit emergency alerts as part of the...

OIG News Release: EPA IG responds to Sen. Vitter's letter about audit report on agency's use of private and alias email accounts to conduct official business

EPA Pesticide Factsheets

Arthur A. Elkins Jr., Inspector General for the U.S. Environmental Protection Agency, has replied to a letter signed and released to the public February 20 byU.S. Sen. David Vitter, Ranking Member of the Senate Committee on Environment and Public Works.

What "You" and "I" Mean to Each Other: Person Indexicals, Self-Ascription, and Theory of Mind

ERIC Educational Resources Information Center

Wechsler, Stephen

2010-01-01

This article offers a DE SE THEORY of person indexicals, wherein first- and second-person indexical pronouns indicate REFERENCE DE SE (also called SELF-ASCRIPTION). Long observed for first-person pronouns (Castaneda 1977, Kaplan 1977, Perry 1979, inter alia), self-ascription is extended here to second person as well. The person feature of a…

Dynamic load balancing for petascale quantum Monte Carlo applications: The Alias method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sudheer, C. D.; Krishnan, S.; Srinivasan, A.

Diffusion Monte Carlo is the most accurate widely used Quantum Monte Carlo method for the electronic structure of materials, but it requires frequent load balancing or population redistribution steps to maintain efficiency and avoid accumulation of systematic errors on parallel machines. The load balancing step can be a significant factor affecting performance, and will become more important as the number of processing elements increases. We propose a new dynamic load balancing algorithm, the Alias Method, and evaluate it theoretically and empirically. An important feature of the new algorithm is that the load can be perfectly balanced with each process receivingmore » at most one message. It is also optimal in the maximum size of messages received by any process. We also optimize its implementation to reduce network contention, a process facilitated by the low messaging requirement of the algorithm. Empirical results on the petaflop Cray XT Jaguar supercomputer at ORNL showing up to 30% improvement in performance on 120,000 cores. The load balancing algorithm may be straightforwardly implemented in existing codes. The algorithm may also be employed by any method with many near identical computational tasks that requires load balancing.« less

Analysis of design characteristics of a V-type support using an advanced engineering environment

NASA Astrophysics Data System (ADS)

Gwiazda, A.; Banaś, W.; Sękala, A.; Cwikla, G.; Topolska, S.; Foit, K.; Monica, Z.

2017-08-01

Modern mining support, for the entire period of their use, is the important part of the mining complex, which includes all the devices in the excavation during his normal use. Therefore, during the design of the support, it is an important task to choose the shape and to select the dimensions of a support as well as its strength characteristics. According to the rules, the design process of a support must take into account, inter alia, the type and the dimensions of the expected means of transport, the number and size of pipelines, and the type of additional equipment used excavation area. The support design must ensure the functionality of the excavation process and job security, while maintaining the economic viability of the entire project. Among others it should ensure the selection of a support for specific natural conditions. It is also important to take into consideration the economic characteristics of the project. The article presents an algorithm of integrative approach and its formalized description in the form of integration the areas of different construction characteristics optimization of a V-type mining support. The paper includes the example of its application for developing the construction of this support. In the paper is also described the results of the characteristics analysis and changings that were introduced afterwards. The support models are prepared in the computer environment of the CAD class (Siemens NX PLM). Also the analyses were conducted in this design, graphical environment.

Driven to extinction? The ethics of eradicating mosquitoes with gene-drive technologies.

PubMed

Pugh, Jonathan

2016-09-01

Mosquito-borne diseases represent a significant global disease burden, and recent outbreaks of such diseases have led to calls to reduce mosquito populations. Furthermore, advances in 'gene-drive' technology have raised the prospect of eradicating certain species of mosquito via genetic modification. This technology has attracted a great deal of media attention, and the idea of using gene-drive technology to eradicate mosquitoes has been met with criticism in the public domain. In this paper, I shall dispel two moral objections that have been raised in the public domain against the use of gene-drive technologies to eradicate mosquitoes. The first objection invokes the concept of the 'sanctity of life' in order to claim that we should not drive an animal to extinction. In response, I follow Peter Singer in raising doubts about general appeals to the sanctity of life, and argue that neither individual mosquitoes nor mosquitoes species considered holistically are appropriately described as bearing a significant degree of moral status. The second objection claims that seeking to eradicate mosquitoes amounts to displaying unacceptable degrees of hubris. Although I argue that this objection also fails, I conclude by claiming that it raises the important point that we need to acquire more empirical data about, inter alia, the likely effects of mosquito eradication on the ecosystem, and the likelihood of gene-drive technology successfully eradicating the intended mosquito species, in order to adequately inform our moral analysis of gene-drive technologies in this context. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Latin America Report No. 2532

DTIC Science & Technology

1982-07-06

Trimarco himself who put forward Nicolaides’ name, according to military sources. Nicolaides’ father was bom in Greece and his mother in Cordoba...telephone companies, and the water works, as well as other terrorist acts aimed at social clubs, embassies, urban transportation, military hospital centers...34), Jesus Maria Pesca Garcia (alias "Chucho"), Nelson Ortiz Ovalle, Wilson Ramirez Hurtado, Jairo Arias Perez, Ricardo Londono, Elvira Reyes de

A Possible Literary Canon in Upper School English Literature in Various Australian States, 1945-2005

ERIC Educational Resources Information Center

Yiannakis, John

2014-01-01

Using information gathered from a specifically created database, ALIAS, this paper sets out to examine the variations and changes to the works that appeared on the English reading lists of the different Australian states in their literature course(s) between 1945 and 2005. All those states which offered a set of public examinations at the end of…

Childhood and Capability Deprivation in Germany: A Quantitative Analysis Using German Socio-Economic Panel Data

ERIC Educational Resources Information Center

Wust, Kirsten; Volkert, Jurgen

2012-01-01

Child poverty has been widely discussed in Germany since the publication of the third official Poverty and Wealth Report of the German government in 2008 which--inter alia--focused on the situation of children and families. However, child poverty is not only caused by low household incomes and impacts of child poverty are not only restricted to…

76 FR 30505 - Authorizing the Implementation of Certain Sanctions Set Forth in the Iran Sanctions Act of 1996...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... Authorizing the Implementation of Certain Sanctions Set Forth in the Iran Sanctions Act of 1996, as Amended By... National Emergencies Act (50 U.S.C. 1601 et seq.), the Iran Sanctions Act of 1996 (Public Law 104-172) (50 U.S.C. 1701 note) (ISA), as amended by, inter alia, the Comprehensive Iran Sanctions, Accountability...

Revealing dressed quarks via the proton's charge distribution.

PubMed

Cloët, Ian C; Roberts, Craig D; Thomas, Anthony W

2013-09-06

The proton is arguably the most fundamental of nature's readily detectable building blocks. It is at the heart of every nucleus and has never been observed to decay. It is nevertheless a composite object, defined by its valence-quark content: u+u+d--i.e., two up (u) quarks and one down (d) quark; and the manner by which they influence, inter alia, the distribution of charge and magnetization within this bound state. Much of novelty has recently been learned about these distributions; and it now appears possible that the proton's momentum-space charge distribution possesses a zero. Experiments in the coming decade should answer critical questions posed by this and related advances; we explain how such new information may assist in charting the origin and impact of key emergent phenomena within the strong interaction. Specifically, we show that the possible existence and location of a zero in the proton's electric form factor are a measure of nonperturbative features of the quark-quark interaction in the standard model, with particular sensitivity to the running of the dressed-quark mass.

Quantifying the Climate-Scale Accuracy of Satellite Cloud Retrievals

NASA Astrophysics Data System (ADS)

Roberts, Y.; Wielicki, B. A.; Sun-Mack, S.; Minnis, P.; Liang, L.; Di Girolamo, L.

2014-12-01

Instrument calibration and cloud retrieval algorithms have been developed to minimize retrieval errors on small scales. However, measurement uncertainties and assumptions within retrieval algorithms at the pixel level may alias into decadal-scale trends of cloud properties. We first, therefore, quantify how instrument calibration changes could alias into cloud property trends. For a perfect observing system the climate trend accuracy is limited only by the natural variability of the climate variable. Alternatively, for an actual observing system, the climate trend accuracy is additionally limited by the measurement uncertainty. Drifts in calibration over time may therefore be disguised as a true climate trend. We impose absolute calibration changes to MODIS spectral reflectance used as input to the CERES Cloud Property Retrieval System (CPRS) and run the modified MODIS reflectance through the CPRS to determine the sensitivity of cloud properties to calibration changes. We then use these changes to determine the impact of instrument calibration changes on trend uncertainty in reflected solar cloud properties. Secondly, we quantify how much cloud retrieval algorithm assumptions alias into cloud optical retrieval trends by starting with the largest of these biases: the plane-parallel assumption in cloud optical thickness (τC) retrievals. First, we collect liquid water cloud fields obtained from Multi-angle Imaging Spectroradiometer (MISR) measurements to construct realistic probability distribution functions (PDFs) of 3D cloud anisotropy (a measure of the degree to which clouds depart from plane-parallel) for different ISCCP cloud types. Next, we will conduct a theoretical study with dynamically simulated cloud fields and a 3D radiative transfer model to determine the relationship between 3D cloud anisotropy and 3D τC bias for each cloud type. Combining these results provides distributions of 3D τC bias by cloud type. Finally, we will estimate the change in frequency of occurrence of cloud types between two decades and will have the information needed to calculate the total change in 3D optical thickness bias between two decades. If we uncover aliases in this study, the results will motivate the development and rigorous testing of climate specific cloud retrieval algorithms.

Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.

PubMed

Thomas, Mark P; Potter, Barry V L

2015-10-08

In 1994, following work from this laboratory, it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potential hormone-dependent cancer target steroid sulfatase (STS). Subsequent drug discovery projects were initiated to develop the core aryl O-sulfamate pharmacophore that, over some 20 years, have led to steroidal and nonsteroidal drugs in numerous preclinical and clinical trials, with promising results in oncology and women's health, including endometriosis. Drugs have been designed to inhibit STS, e.g., Irosustat, as innovative dual-targeting aromatase-steroid sulfatase inhibitors (DASIs) and as multitargeting agents for hormone-independent tumors, such as the steroidal STX140 and nonsteroidal counterparts, acting inter alia through microtubule disruption. The aryl sulfamate pharmacophore is highly versatile, operating via three distinct mechanisms of action, and imbues attractive pharmaceutical properties. This Perspective gives a personal view of the work leading both to the therapeutic concepts and these drugs, their current status, and how they might develop in the future.

Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women’s Health

PubMed Central

Thomas, Mark P.; Potter, Barry V. L.

2016-01-01

In 1994, following work from this laboratory, it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potential hormone-dependent cancer target steroid sulfatase (STS). Subsequent drug discovery projects were initiated to develop the core aryl O-sulfamate pharmacophore that, over some twenty years, have led to steroidal and non-steroidal drugs in numerous pre-clinical and clinical trials, with promising results in oncology and women’s health, including endometriosis. Drugs have been designed to inhibit STS e.g. Irosustat, as innovative dual-targeting aromatase-steroid sulfatase inhibitors (DASIs) and as multi-targeting agents for hormone-independent tumors, such as the steroidal STX140 and non-steroidal counterparts, acting inter alia through microtubule disruption. The aryl sulfamate pharmacophore is highly versatile, operating via three distinct mechanisms of action and imbues attractive pharmaceutical properties. This Perspectives article gives a personal view of the work leading both to the therapeutic concepts and these drugs, their current status and how they might develop in the future. PMID:25992880

Quantifying redox-induced Schottky barrier variations in memristive devices via in operando spectromicroscopy with graphene electrodes

PubMed Central

Baeumer, Christoph; Schmitz, Christoph; Marchewka, Astrid; Mueller, David N.; Valenta, Richard; Hackl, Johanna; Raab, Nicolas; Rogers, Steven P.; Khan, M. Imtiaz; Nemsak, Slavomir; Shim, Moonsub; Menzel, Stephan; Schneider, Claus Michael; Waser, Rainer; Dittmann, Regina

2016-01-01

The continuing revolutionary success of mobile computing and smart devices calls for the development of novel, cost- and energy-efficient memories. Resistive switching is attractive because of, inter alia, increased switching speed and device density. On electrical stimulus, complex nanoscale redox processes are suspected to induce a resistance change in memristive devices. Quantitative information about these processes, which has been experimentally inaccessible so far, is essential for further advances. Here we use in operando spectromicroscopy to verify that redox reactions drive the resistance change. A remarkable agreement between experimental quantification of the redox state and device simulation reveals that changes in donor concentration by a factor of 2–3 at electrode-oxide interfaces cause a modulation of the effective Schottky barrier and lead to >2 orders of magnitude change in device resistance. These findings allow realistic device simulations, opening a route to less empirical and more predictive design of future memory cells. PMID:27539213

Quantifying redox-induced Schottky barrier variations in memristive devices via in operando spectromicroscopy with graphene electrodes.

PubMed

Baeumer, Christoph; Schmitz, Christoph; Marchewka, Astrid; Mueller, David N; Valenta, Richard; Hackl, Johanna; Raab, Nicolas; Rogers, Steven P; Khan, M Imtiaz; Nemsak, Slavomir; Shim, Moonsub; Menzel, Stephan; Schneider, Claus Michael; Waser, Rainer; Dittmann, Regina

2016-08-19

The continuing revolutionary success of mobile computing and smart devices calls for the development of novel, cost- and energy-efficient memories. Resistive switching is attractive because of, inter alia, increased switching speed and device density. On electrical stimulus, complex nanoscale redox processes are suspected to induce a resistance change in memristive devices. Quantitative information about these processes, which has been experimentally inaccessible so far, is essential for further advances. Here we use in operando spectromicroscopy to verify that redox reactions drive the resistance change. A remarkable agreement between experimental quantification of the redox state and device simulation reveals that changes in donor concentration by a factor of 2-3 at electrode-oxide interfaces cause a modulation of the effective Schottky barrier and lead to >2 orders of magnitude change in device resistance. These findings allow realistic device simulations, opening a route to less empirical and more predictive design of future memory cells.

Quantifying redox-induced Schottky barrier variations in memristive devices via in operando spectromicroscopy with graphene electrodes

NASA Astrophysics Data System (ADS)

Baeumer, Christoph; Schmitz, Christoph; Marchewka, Astrid; Mueller, David N.; Valenta, Richard; Hackl, Johanna; Raab, Nicolas; Rogers, Steven P.; Khan, M. Imtiaz; Nemsak, Slavomir; Shim, Moonsub; Menzel, Stephan; Schneider, Claus Michael; Waser, Rainer; Dittmann, Regina

2016-08-01

The continuing revolutionary success of mobile computing and smart devices calls for the development of novel, cost- and energy-efficient memories. Resistive switching is attractive because of, inter alia, increased switching speed and device density. On electrical stimulus, complex nanoscale redox processes are suspected to induce a resistance change in memristive devices. Quantitative information about these processes, which has been experimentally inaccessible so far, is essential for further advances. Here we use in operando spectromicroscopy to verify that redox reactions drive the resistance change. A remarkable agreement between experimental quantification of the redox state and device simulation reveals that changes in donor concentration by a factor of 2-3 at electrode-oxide interfaces cause a modulation of the effective Schottky barrier and lead to >2 orders of magnitude change in device resistance. These findings allow realistic device simulations, opening a route to less empirical and more predictive design of future memory cells.

Listening to the Learners' Voices in HE: How Do Students Reflect on Their Use of Technology for Learning?

ERIC Educational Resources Information Center

Jefferies, Amanda; Hyde, Ruth

2009-01-01

The importance of the Learner's Voice and thus of listening to students' views has been evidenced in various high profile initiatives in the UK. The work presented here is from the JISC Learners' Experiences of E-Learning Phase 2 Learners' Journeys STROLL project. The seven JISC funded projects were set up in 2007 to investigate inter alia the…

Exploring the Acoustic Nonlinearity for Monitoring Complex Aerospace Structures

DTIC Science & Technology

2008-02-27

nonlinear elastic waves, embedded ultrasonics, nonlinear diagnostics, aerospace structures, structural joints. 16. SECURITY CLASSIFICATION OF: 17...sampling, 100 MHz bandwidth with noise and anti- aliasing filters, general-purpose alias-protected decimation for all sample rates and quad digital down...conversion ( DDC ) with up to 40 MHz IF bandwidth. Specified resolution of NI PXI 5142 is 14-bits with the noise floor approaching -85 dB. Such a

Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancer.

PubMed

Kettunen, Eeva; Anttila, Sisko; Seppänen, Jouni K; Karjalainen, Antti; Edgren, Henrik; Lindström, Irmeli; Salovaara, Reijo; Nissén, Anna-Maria; Salo, Jarmo; Mattson, Karin; Hollmén, Jaakko; Knuutila, Sakari; Wikman, Harriet

2004-03-01

The expression patterns of cancer-related genes in 13 cases of squamous cell lung cancer (SCC) were characterized and compared with those in normal lung tissue and 13 adenocarcinomas (AC), the other major type of nonsmall cell lung cancer (NSCLC). cDNA array was used to screen the gene expression levels and the array results were verified using a real-time reverse-transcriptase-polymerase chain reaction (RT-PCR). Thirty-nine percent of the 25 most upregulated and the 25 most downregulated genes were common to SCC and AC. Of these genes, DSP, HMGA1 (alias HMGIY), TIMP1, MIF, CCNB1, TN, MMP11, and MMP12 were upregulated and COPEB (alias CPBP), TYROBP, BENE, BMPR2, SOCS3, TIMP3, CAV1, and CAV2 were downregulated. The expression levels of several genes from distinct protein families (cytokeratins and hemidesmosomal proteins) were markedly increased in SCC compared with AC and normal lung. In addition, several genes, overexpressed in SCC, such as HMGA1, CDK4, IGFBP3, MMP9, MMP11, MMP12, and MMP14, fell into distinct chromosomal loci, which we have detected as gained regions on the basis of comparative genomic hybridization data. Our study revealed new candidate genes involved in NSCLC.

High Resolution Geological Site Characterization Utilizing Ground Motion Data

DTIC Science & Technology

1992-06-26

Hayward, 1992). 15 Acquistion I 16 The source characterization array was composed of 28 stations evenly 17 distributed on the circumference of a...of analog anti alias filters, no prefiltering was applied during II acquistion . 12 Results 13 We deployed 9 different sources within the source...calculated using a 1024 point Hamming window applied to 32 the original 1000 point detrended and padded time series. These are then contoured as a 33

Bibliography on Future Trends in Terrorism

DTIC Science & Technology

1998-09-01

Bernhard Restel, et alia. "La police en interfaces: Colloque universitaire de l’Institut Suisse de Police," Revue Internationale de Criminologie et...Convenzione di Ginevra per l’Istituzione di una Corte Penale Internazionale sul Terrorismo : Un document da tornare a leggere," Il Politico, [Rome], 62...The author, who is president of Peru , points out that terrorist organizations in Peru have struggled for a decade to erode the democratic system and

Why Do Model Tropical Cyclones Intensify More Rapidly at Low Latitudes?

DTIC Science & Technology

2015-05-01

angularmomentum, greatly surpass the effects of rotational stiffness (inertial stability) and evaporative-wind feedback that have been proposed in...sification in a quiescent environment and have examined, inter alia, the effect of latitude on vortex evolution (e.g., DeMaria and Pickle 1988; Smith et al... Coriolis parameter. This time scale is about 16 h for latitudes of interest considered by Carrier, and it emerges by determining the time re- quired

NAVO MSRC Navigator. Spring 2003

DTIC Science & Technology

2003-01-01

computational model run on the IBM POWER4 (MARCELLUS) in support of the Airborne Laser Challenge Project II. The data were visualized using Alias|Wavefront Maya...Turbulence in a Jet Stream in the Airborne Laser Context High Performance Computing 11 Largest NAVO MSRC System Becomes Even Bigger and Better 11 Using the smp...centimeters (cm). The resolution requirement to resolve the microjets and the flow outside in the combustor is too severe for any single numerical method

Precision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study.

PubMed

Agarwal, Rahul; Cao, Yuan; Hoffmeier, Klaus; Krezdorn, Nicolas; Jost, Lukas; Meisel, Alejandro Rodriguez; Jüngling, Ruth; Dituri, Francesco; Mancarella, Serena; Rotter, Björn; Winter, Peter; Giannelli, Gianluigi

2017-06-08

The aim of this study was to design a road map for personalizing cancer therapy in hepatocellular carcinoma (HCC) by using molecular pattern diagnostics. As an exploratory study, we investigated molecular patterns of tissues of two tumors from individual HCC patients, which in previous experiments had shown contrasting reactions to the phase 2 transforming growth factor beta receptor 1 inhibitor galunisertib. Cancer-driving molecular patterns encompass - inter alias - altered transcription profiles and somatic mutations in coding regions differentiating tumors from their respective peritumoral tissues and from each other. Massive analysis of cDNA ends and all-exome sequencing demonstrate a highly divergent transcriptional and mutational landscape, respectively, for the two tumors, that offers potential explanations for the tumors contrasting responses to galunisertib. Molecular pattern diagnostics (MPDs) suggest alternative, individual-tumor-specific therapies, which in both cases deviate from the standard sorafenib treatment and from each other. Suggested personalized therapies use kinase inhibitors and immune-focused drugs as well as low-toxicity natural compounds identified using an advanced bioinformatics routine included in the MPD protocol. The MPD pipeline we describe here for the prediction of suitable drugs for treatment of two contrasting HCCs may serve as a blueprint for the design of therapies for various types of cancer.

Application of Terrestrial Laser Scanner with an Integrated Thermal Camera in Non-Destructive Evaluation of Concrete Surface of Hydrotechnical Objects

NASA Astrophysics Data System (ADS)

Kaczmarek, Łukasz Dominik; Dobak, Paweł Józef; Kiełbasiński, Kamil

2017-12-01

The authors present possible applications of thermal data as an additional source of information on an object's behaviour during the technical assessment of the condition of a concrete surface. For the study one of the most recent propositions introduced by Zoller + Fröhlich company was used, which is an integration of a thermal camera with a terrestrial laser scanner. This solution enables an acquisition of geometric and spectral data on the surveyed object and also provides information on the surface's temperature in the selected points. A section of the dam's downstream concrete wall was selected as the subject of the study for which a number of scans were carried out and a number of thermal images were taken at different times of the day. The obtained thermal data was confronted with the acquired spectral information for the specified points. This made it possible to carry out broader analysis of the surface and an inspection of the revealed fissure. The thermal analysis of said fissure indicated that the temperature changes within it are slower, which may affect the way the concrete works and may require further elaboration by the appropriate experts. Through the integration of a thermal camera with a terrestrial laser scanner one can not only analyse changes of temperature in the discretely selected points but on the whole surface as well. Moreover, it is also possible to accurately determine the range and the area of the change affecting the surface. The authors note the limitations of the presented solution like, inter alia, the resolution of the thermal camera.

Curvatures Estimation in Orientation Selection

DTIC Science & Technology

1991-01-31

processes are run at the same scale ). Not only is the L/L edge operator as accurate, it makes explicit a great deal of information which is either...Figure 11: An artificial image used to test the image operators. This is an anti-alia sed grey- scale image of lines and curves, which represent the...MacKay, "Influence of luminance gra- dient reversal on simple cells in feline striate cortex," J. Physiology (London), vol. 337, pp. 69--87, 1983

Gender stress: a preliminary survey with specific reference to female physicians.

PubMed

Davis, E M

1993-09-01

Practicing female physicians in Trinidad and Tobago were studied to identify major causal factors of negative stress. Results indicated that major stressors were as follows: job (36%), finance (32%), children (20%), relationships (20%). The minor stressors identified were: children (48%), finance (36%), relationships (36%), job (32%), and health (20%). The physicians showed the ability to cope with the stress and this was attributed to, inter alia, self-sufficiency, empowerment, self-fulfillment and gender.

RHIC AND THE PURSUIT OF THE QUARK-GLUON PLASMA.

DOE Office of Scientific and Technical Information (OSTI.GOV)

MITCHELL,J.T.

2001-07-25

There is a fugitive on the loose. Its name is Quark-Gluon Plasma, alias the QGP. The QGP is a known informant with knowledge about the fundamental building blocks of nature that we wish to extract. This briefing will outline the status of the pursuit of the elusive QGP. We will cover what makes the QGP tick, its modus operandi, details on how we plan to hunt the fugitive down, and our level of success thus far.

Kinetic Resolution of Secondary Alcohols Using Amidine-Based Catalysts

PubMed Central

Li, Ximin; Jiang, Hui; Uffman, Eric W.; Guo, Lei; Zhang, Yuhua; Yang, Xing; Birman, Vladimir B.

2012-01-01

Kinetic resolution of racemic alcohols has been traditionally achieved via enzymatic enantioselective esterification and ester hydrolysis. However, there has long been considerable interest in devising nonenzymatic alternative methods for this transformation. Amidine-Based Catalysts (ABCs), a new class of enantioselective acyl transfer catalysts developed in our group, have demonstrated, inter alia, high efficacy in the kinetic resolution of benzylic, allylic and propargylic secondary alcohols and 2-substituted cycloalkanols, and thus provide a viable alternative to enzymes. PMID:22283696

The Use of Ion Implantation for Materials Processing.

DTIC Science & Technology

1984-08-23

Amsterdam. 1983) p. 35 5 . 191 J.M. Lambert. P.A. Treado. D . Trbojevic . R.(; Alias. A.R 13J N.,.W. Hartley, K.S. (Graboski, C.R. (jossett and...Technology 105, pp.53 4-541,(1983). 89. J. M. Lambert, P. A. Treado, D . Trbojevic , R. G. Allas, A. R. Knudson, G. W. Reynolds, and F. R. Vozzo...VACUUM CARBURIZATION IN STEEL . .................................... 21 D . Farkas, 1. L. Singer, and M. Rangaswamy D . BOLTZMANN APPROACH TO CASCADE

[Vest recorder used in diagnostics of occasionally occurring supraventricular tachycardia nearby sinus node - a case report].

PubMed

Adamczyk, Karolina; Średniawa, Beata; Mitręga, Katarzyna; Morawski, Stanisław; Musialik-Łydka, Agata; Kalarus, Zbigniew

2016-09-29

Symptoms such as palpitations, fainting, dizziness and unexplained loss of consciousness are often notified by patients in clinical practice. Cardiological causes of these ailments could be various, inter alia, atriaventricular conduction disorders, supraventricular arrythmias or more life-threatening ventricular arrythmias. Diagnostics of these disorders includes a series of basic non-invasive research and more advanced specialistic methods. Presented case report shows problems of arrythmias diagnostics and imperfections of avaible methods.

Proceedings of the International Symposium on the Dynamics and Structures of Terrorist Threats in Southeast Asia, Held at Kuala Lumpur, Malaysia

DTIC Science & Technology

2005-09-01

Radicalization ............................ III-55 The Rise of Radical Political Islam in Southeast Asia: A Malaysian Perspective...the already stretched US component. In addition to plans to hit a US warship off the Malaysian waters, Tawfiq bin Attash alias Khallad, the deputy... Malaysian Army Captain and a US-trained biochemist was also the head of Al Qaeda’s Anthrax Program in Kandahar in Afghanistan.8 Zacarias Moussaoui

Some of the Best Weapons for Counterinsurgents Do Not Shoot (The Letort Papers)

DTIC Science & Technology

2010-10-01

stable and productive Germany.”4 The restrictions placed on production from German heavy industry were partly rescinded, and allowable steel...So, inter alia, there was a carrot and stick effect desired: The idea was to win the loyalties of the local people away from the insurgents by offer...diverting resources needed to bring elec- tricity to an economic development zone built around businesses and industry that will need electricity to

MM&T: Bibliography on Optical Testing with Appendix.

DTIC Science & Technology

1982-02-26

OTTENUTE CON UN RETICOLO A TRATTI INCLINATI SUL PIANO DE SIM1ETRIA DEL SISTEMA OTTICO" Nuovo Cimento, 8, 310 (1931) No abstract provided. SCANDONE, F...FRANCIA, G. "SULLA FRANGE D’INTERFERENZA DELLE ONDE ABERRANTI" Ottica. 6, 151 (1941) No abstract provided. TORALDO DI FRANCIA, G. "SAUGIO DI UNA TEORIA ...No abstract provided. TORALDO DI FRANCIA, G. "INTRODUZIONE ALIA TEORIA GEOMETR[CA E INTERFERENZIALE DELLE ONDE ABERRANTI" Atti. Fond. Giorgio Ronchi

Oil and gas field code master list 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Oil and Gas Field Code Master List 1997 is the sixteenth annual listing of all identified oil and gas fields in the US. It is updated with field information collected through October 1997. The purpose of this publication is to provide unique, standardized codes for identification of domestic fields. Use of these field codes fosters consistency of field identification by government and industry. As a result of their widespread adoption they have in effect become a national standard. The use of field names and codes listed in this publication is required on survey forms and other reports regarding field-specificmore » data collected by EIA. There are 58,366 field records in this year`s FCML, 437 more than last year. The FCML includes: field records for each State and county in which a field resides; field records for each offshore area block in the Gulf of Mexico in which a field resides; field records for each alias field name (definition of alias is listed); fields crossing State boundaries that may be assigned different names by the respective State naming authorities. This report also contains an Invalid Field Record List of 4 records that have been removed from the FCML since last year`s report. These records were found to be either technically incorrect or to represent field names which were never recognized by State naming authorities.« less

Does one need a 4.5 K screen in cryostats of superconducting accelerator devices operating in superfluid helium? lessons from the LHL

NASA Astrophysics Data System (ADS)

Lebrun, Philippe; Parma, Vittorio; Tavian, Laurent

2014-01-01

Superfluid helium is increasingly used as a coolant for superconducting devices in particle accelerators: the lower temperature enhances the performance of superconductors in high-field magnets and reduces BCS losses in RF acceleration cavities, while the excellent transport properties of superfluid helium can be put to work in efficient distributed cooling systems. The thermodynamic penalty of operating at lower temperature however requires careful management of the heat loads, achieved inter alia through proper design and construction of the cryostats. A recurrent question appears to be that of the need and practical feasibility of an additional screen cooled by normal helium at around 4.5 K surrounding the cold mass at about 2 K, in such cryostats equipped with a standard 80 K screen. We introduce the issue in terms of first principles applied to the configuration of the cryostats, discuss technical constraints and economical limitations, and illustrate the argumentation with examples taken from large projects confronted with this issue, i.e. CEBAF, SPL, ESS, LHC, TESLA, European X-FEL, ILC.

Playing with Quantum Toys: Julian Schwinger's Measurement Algebra and the Material Culture of Quantum Mechanics Pedagogy at Harvard in the 1960s

NASA Astrophysics Data System (ADS)

Gauvin, Jean-François

2018-03-01

In the early 1960s, a PhD student in physics, Costas Papaliolios, designed a simple—and playful—system of Polaroid polarizer filters with a specific goal in mind: explaining the core principles behind Julian Schwinger's quantum mechanical measurement algebra, developed at Harvard in the late 1940s and based on the Stern-Gerlach experiment confirming the quantization of electron spin. Papaliolios dubbed his invention "quantum toys." This article looks at the origins and function of this amusing pedagogical device, which landed half a century later in the Collection of Historical Scientific Instruments at Harvard University. Rendering the abstract tangible was one of Papaliolios's demonstration tactics in reforming basic teaching of quantum mechanics. This article contends that Papaliolios's motivation in creating the quantum toys came from a renowned endeavor aimed, inter alia, at reforming high-school physics training in the United States: Harvard Project Physics. The pedagogical study of these quantum toys, finally, compels us to revisit the central role playful discovery performs in pedagogy, at all levels of training and in all fields of knowledge.

Physics and Religion

NASA Astrophysics Data System (ADS)

Finegold, Leonard; Thomson-Hohl, Timothy; Tyagi, Som

2010-02-01

Aspects of religion with science/religion have been covered in the pages of Physics Today and Physics News. They reflect wide student interest in these topics. For a decade, two physicists and a campus minister have taught a writing-intensive course ``Issues in Science and Religion'' Physics/Sociology 137. Here we outline our course (open to all students), to encourage others contemplating similar courses. Many students escape an exposure to the basics of science, and so we capture them. We discuss inter alia relativity and uncertainties (both quantum and classical, which fascinate students), including their controversial relationships with religion. One of us (LF), as a biophysicist, was asked to cover evolution, which topic has proved to be rather popular: Various scientific organizations have publicly defended evolution against intelligent design and creationism. To keep the quality of the course, we have restricted enrollment. Here we discuss only the science/physics part of the course. Visiting speakers (covering the gamut from religious to non-religious) have included a Vatican astronomer, a Sloan survey cosmologist, the director of SETI, a neuropsychologist, a sociologist, historians of science and theologians. )

THE ROTATION PERIOD AND LIGHT-CURVE AMPLITUDE OF KUIPER BELT DWARF PLANET 136472 MAKEMAKE (2005 FY9)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heinze, A. N.; DeLahunta, Daniel

Kuiper Belt dwarf planet 136472 Makemake, formerly known as 2005 FY9, is currently the third-largest known object in the Kuiper Belt, after the dwarf planets Pluto and Eris. It is currently second only to Pluto in apparent brightness, due to Eris' much larger heliocentric distance. Makemake shows very little photometric variability, which has prevented confident determination of its rotation period until now. Using extremely precise time-series photometry, we find that the rotation period of Makemake is 7.7710 {+-} 0.0030 hr, where the uncertainty is a 90% confidence interval. An alias period is detected at 11.41 hr, but is determined withmore » approximately 95% confidence not to be the true period. Makemake's 7.77 hr rotation period is in the typical range for Kuiper Belt objects, consistent with Makemake's apparent lack of a substantial satellite to alter its rotation through tides. The amplitude of Makemake's photometric light curve is 0.0286 {+-} 0.0016 mag in V. This amplitude is about 10 times less than Pluto's, which is surprising given the two objects' similar sizes and spectral characteristics. Makemake's photometric variability is instead similar to that of Eris, which is so small that no confident rotation period has yet been determined. It has been suggested that dwarf planets such as Makemake and Eris, both farther from the Sun and colder than Pluto, exhibit lower photometric variability because they are covered with a uniform layer of frost. Such a frost is probably the correct explanation for Eris. However, it may be inconsistent with the spectrum of Makemake, which resembles reddish Pluto more than neutrally colored Eris. Makemake may instead be a more Pluto-like object that we observe at present with a nearly pole-on viewing geometry-a possibility that can be tested with continuing observations over the coming decades.« less

Complex Envelope Properties, Interpretation, Filtering, and Evaluation

DTIC Science & Technology

1991-02-01

BEHAVIOR The example of y(t) in (45) (when n# ± /2) illustrates the general rule that if a time function has a discontinuity of value D at time to, then...integration rule like trapezoidal, the "alias-free" interval in the time domain is approximately halved, as shown below. This does not necessarily mean that...approximated by the trapezoidal rule and the results added together. The two final approximations of interest come from sampling the results for causal real y(t

The Effects of Management Support on the Successful Implementation of Group Decision Support Systems

DTIC Science & Technology

1990-05-23

also provides for decisions which must be made by more than one person [Straub and Beauclair , 1987, pp 1]. 38 With a broad definition of GDSS any tool...Figure 5 represents the definition of GDSS categories used by this study [Straub and Beauclair , 1987]. Alias and DeSanctis & GDSS Name Gallupe type...DeSanctis and Gallupe, 1987]. Straub and Beauclair combined types 2 and 4 into one category. 39 Type 1 is a Decision Room, consisting of a face-to

The Development and Validation of Audiovisual Simulated Performance Tests Using 35mm Slides

DTIC Science & Technology

1979-05-01

is not observed, the data of Group A And B permit the investigation of a further comparison, i.e., whether an AVS tesi is less valid...CM» Ali(A NtU U trMcKklMt «tin MrU •■ Orlttr «M Cl^ In»«rt Sen« tat Um* TlfklM Oktal* AHM «rMtk UMft IM* Str*a «M TlfklM S*cur*lr MylM* TMI

A new photostabilizer: Hydrogenated benzoin derivatives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamaguchi, K.; Ohkatsu, Y.

1993-12-31

It is found that synergistic effects based on combined use of HALS (hindered Amine Light Stabilizers) with phenolic antioxidants consist of the action of HALS as hydrogen donor to quinones, derived from the phenol in autoxidation, excited by uv light. The finding has been realized as a new photostabilizer of hydrogenated benzoin derivatives. They are generally characterized by multifunctions. The o,o`-dihydroxyl-substituted derivatives inter alia extend the life of a phenolic antioxidant co-used, as hydrogen donor, as well as ultimately act as uv absorber.

Future aeromedical assessment in general aviation: a contribution to the actual discussion

PubMed Central

Siedenburg, J

2008-01-01

The past years saw a transition of competencies from the Joint Aviation Authorities (JAA) to the European Aviation Safety Agency (EASA), which was founded in 2003, based on EU Regulation 1592/02. EASA started its work in the fields of Airworthiness and will soon its competencies inter alia to Flight Operations and Flight Crew Licensing, the latter including the requirements for aeromedical assessment. The appropriate new EU Regulation will most probably be published in April. It includes the Essential Requirements for Licensing and aeromedical certification. A proposal for a new Commission Regulation promulgates the Implementing Rules for Personnel Licensing, detailing – inter alia – the Medical Requirements (Annex II to the Regulation). The specific rules, numeric standards are published as Acceptable Means of Compliance (AMC) and Guidance Material (GM). The provisions are based on JAR-FCL 3 and have been transposed to the format choosen by EASA by a small working group of aeromedical experts (FCL.001). Comments received by the European Aviation Safety Agency (EASA) prompted the agencys statement that the JAR-FCL 3 requirements for private pilots were excessive and too demanding and that a better regulation in General Aviation had to be developed. Another working group (MDM.032), including one aeromedical specialist, was tasked to draft a set of lighter requirements for non-complex aircraft used in non-commercial operations. In this context a much lighter form of aeromedical assessment - involving self-declaration by the pilot and general practitioners as asessors – has been proposed. PMID:19048096

Possible Responsibility of Silicone Materials for Degradation of the CO2 Removal System in the International Space Station

NASA Technical Reports Server (NTRS)

Baeza, Mario; Sharma, Hemant; Borrok, David; Ren, Mingua; Pannell, Keith

2011-01-01

From data concerning the degradation of the CO2 removal system in the International Space Station (ISS) two important features were apparent: (1) The atmosphere within the International Space Station (ISS) contained many organic compounds including alcohols, halocarbons, aldehydes, esters, and ketones, inter alia. Various cyclosiloxanes Dn, hexamethylcyclotrisiloxane (D3) and its higher homologs (D4) and (D5) are also present presumably due to offgassing. (2) Screens within the zeolite-containing canisters, used for the removal of CO2, exhibited partial clogging due to zeolitic fragments (dust) along with "sticky" residues, that in toto significantly reduced the efficiency of the CO2 removal process. Samples of the ISS fresh zeolite, used zeolite, filter clogging zeolite particles and residual polymeric materials were examined using, inter alia, NMR, EM and HRSEM. These data were compared to equivalent samples obtained prior and subsequent to Dn polymerization experiments performed in our laboratories using the clean ISS zeolite samples as catalyst. Polysiloxane materials produced were essentially equivalent in the two cases and the EM images demonstrate a remarkable similarity between the ISS filter zeolite samples and the post-polymerization zeolite material from our experiments. In this regard even the changes in the Al/Si ratio from the virgin zeolite material to the filter samples and the post-polymerization laboratory samples samples is noteworthy. This research was supported by a contract from the Boeing Company

Structural evolution of Cenozoic basins in northeastern Tunisia, in response to sinistral strike-slip movement on the El Alia-Teboursouk Fault

NASA Astrophysics Data System (ADS)

Bejaoui, Hamida; Aïfa, Tahar; Melki, Fetheddine; Zargouni, Fouad

2017-10-01

This paper resolves the structural complexity of Cenozoic sedimentary basins in northeastern Tunisia. These basins trend NE-SW to ∼ E-W, and are bordered by old fracture networks. Detailed descriptions of the structural features in outcrop and in subsurface data suggest that the El Alia-Teboursouk Fault zone in the Bizerte area evolved through a series of tectonic events. Cross sections, lithostratigraphic correlations, and interpretation of seismic profiles through the basins show evidence for: (i) a Triassic until Jurassic-Early Cretaceous rifting phase that induced lateral variations of facies and strata thicknesses; (ii) a set of faults oriented NE-SW, NW-SE, N-S, and E-W that guided sediment accumulation in pull-apart basins, which were subject to compressive and transpressive deformation during Eocene (Lutetian-Priabonian), Miocene (Tortonian), and Pliocene-Quaternary; and (iii) NNW-SSE to NS contractional events that occurred during the Late Pliocene. Part of the latest phase has been the formation of different synsedimentary folded structures with significant subsidence inversion. Such events have been responsible for the reactivation of inherited faults, and the intrusion of Triassic evaporites, ensuring the role of a slip layer. The combined effects of the different paleoconstraints and halokinetic movements are at the origin of the evolution of these pull-apart basins. The subsurface data suggest that an important fault displacement occurred during the Mesozoic-Cenozoic. The patterns of sediment accumulation in the different basins reflect a high activity of deep ancient faults.

Veterinary parasitology teaching at London - Meeting the 'Day-One Competency' needs of new veterinarians.

PubMed

Fox, Mark; Blake, Damer; Jacobs, Dennis

2018-04-30

Over the past four decades, there has been an exponential increase in veterinary parasitology knowledge, coinciding with the advent of molecular biology in research. Therefore, it is unrealistic for teachers to expect students to graduate with an encyclopaedic knowledge of the subject. As a result, a new curriculum was introduced at The Royal Veterinary College (University of London) in 2007, designed to meet the needs of our new graduates, i.e. RCVS Day-One Competences. The aims of this curriculum are, inter alia, to ensure that new graduates have an up-to-date body of core knowledge and are able to apply such knowledge and newly-acquired information to scientific and clinical problem-solving. Veterinary parasitology is taught primarily in Year 2, following a brief introduction in Year 1; clinical aspects are covered in Year 3, with original research projects undertaken in Years 4 and 5. Parasitology is taught in parallel with other subjects, enabling both horizontal and vertical integration. Core material is provided in lectures supplemented by directed learning (DL) in small groups and interactive, clinical scenario-based practical classes. Student learning is supported by Moodle 3.2 (Virtual Learning Environment [VLE], RVC Learn) which provides access to an on-line study guide (annotated using Adobe Reader), PowerPoint presentations with synchronized lecturer commentary (Echo Active Learning Platform [ALP]), detailed feedback for DL and practical classes, parasite 'potcasts' and CAL packages, and a Clinical Skills Centre. A parasitology textbook has also been published recently to support courses taught at the College. Assessment of student learning is achieved using a variety of written formats (essay, problem-solving questions [PSQ], multiple choice questions [MCQ] and extended matching questions [EMQ]), integrated oral examinations and objective structured clinical examinations (OSCEs). Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.

JPRS Report, China.

DTIC Science & Technology

1991-12-10

For example, " Kuo Wei-hsien" [6753 1919 6343] comment on the above phenomena. He said, "someone is the alias for a certain small group in Europe, and...words, the restructuring of the NSB is but a question of jurisdiction. As for the setup, it Ch’en Shih -meng’s father told him from the time he was will... Shih -meng said his youth was mostly spent at a sugar refinery in a small place in the south. He was quite removed from politics. "I joined Professor’s

Encapsulation methods for solid radionuclide production targets at a medium-energy cyclotron facility

NASA Astrophysics Data System (ADS)

Steyn, Gideon; Vermeulen, Christiaan; Isaacs, Eugene

2018-05-01

The techniques employed at iThemba LABS for the encapsulation of solid radionuclide production targets, based on cold indentation welding, electron beam welding and laser welding, are described. Some aspects of the target holders and cooling requirements to bombard targets in a tandem configuration with a 66 MeV proton beam, with intensities up to nominally 250 A, are also briefly discussed. These techniques are inter alia suitable for a production regimen compatible with the new generation of commercial, high-intensity 70 MeV cyclotrons.

Juridification, medicalisation, and the impact of EU Law: patient mobility and the allocation of scarce NHS resources.

PubMed

Veitch, Kenneth

2012-01-01

This article explores the relationship between EU Law and the allocation of scarce NHS resources in the context of the EU's objective of facilitating access to health care for patients within the EU. Focusing on the Watts case and the recently adopted EU Patients' Rights Directive, the article addresses the political and economic aspects of the implications of EU Law for, inter alia, domestic law, medicine, and the NHS. It does so through developing an analytical framework comprising the notions of juridification and medicalisation. Those notions, which are drawn here from the work of Jürgen Habermas, Ivan Illich, and Sheila McLean, are not only helpful as means of thinking through the nature of the specific EU laws considered in the article; by virtue of their broader focus on, and critique of, the welfare state, they offer an opportunity to reflect more generally on the implications of these laws for the role of the welfare state and medical and legal professionals in the development of the EU's internal market in health care services. Having undertaken this analysis, the article argues that, in order to capture the developments and implications of EU Law on patient mobility, it is necessary to update and partially reformulate the notions of medicalisation and juridification.

Alternative Strategies in Response to Saline Stress in Two Varieties of Portulaca oleracea (Purslane).

PubMed

Mulry, Kristina R; Hanson, Bryan A; Dudle, Dana A

2015-01-01

Purslane (Portulaca oleracea) is a globally-distributed plant with a long history of use in folk medicine and cooking. We have developed purslane as a model system for exploring plant responses to stress. We exposed two varieties of purslane to saline stress with the objective of identifying differences between the varieties in the plasticity of morphological and physiological traits. The varieties responded to saline stress with significantly different changes in the measured traits, which included inter alia biomass, flower counts, proline concentrations and betalain pigment concentrations. The alternative responses of the two varieties consisted of complex, simultaneous changes in multiple traits. In particular, we observed that while both varieties increased production of betalain pigments and proline under saline stress, one variety invested more in betalain pigments while the other invested more in proline. Proline and betalain pigments undoubtedly play multiple roles in plant tissues, but in this case their role as antioxidants deployed to ameliorate saline stress appears to be important. Taken holistically, our results suggest that the two varieties employ different strategies in allocating resources to cope with saline stress. This conclusion establishes purslane as a suitable model system for the study of saline stress and the molecular basis for differential responses.

Alternative Strategies in Response to Saline Stress in Two Varieties of Portulaca oleracea (Purslane)

PubMed Central

Mulry, Kristina R.; Hanson, Bryan A.; Dudle, Dana A.

2015-01-01

Purslane (Portulaca oleracea) is a globally-distributed plant with a long history of use in folk medicine and cooking. We have developed purslane as a model system for exploring plant responses to stress. We exposed two varieties of purslane to saline stress with the objective of identifying differences between the varieties in the plasticity of morphological and physiological traits. The varieties responded to saline stress with significantly different changes in the measured traits, which included inter alia biomass, flower counts, proline concentrations and betalain pigment concentrations. The alternative responses of the two varieties consisted of complex, simultaneous changes in multiple traits. In particular, we observed that while both varieties increased production of betalain pigments and proline under saline stress, one variety invested more in betalain pigments while the other invested more in proline. Proline and betalain pigments undoubtedly play multiple roles in plant tissues, but in this case their role as antioxidants deployed to ameliorate saline stress appears to be important. Taken holistically, our results suggest that the two varieties employ different strategies in allocating resources to cope with saline stress. This conclusion establishes purslane as a suitable model system for the study of saline stress and the molecular basis for differential responses. PMID:26398279

The Use of Drones in Spain: Towards a Platform for Controlling UAVs in Urban Environments.

PubMed

Chamoso, Pablo; González-Briones, Alfonso; Rivas, Alberto; Bueno De Mata, Federico; Corchado, Juan Manuel

2018-05-03

Rapid advances in technology make it necessary to prepare our society in every aspect. Some of the most significant technological developments of the last decade are the UAVs (Unnamed Aerial Vehicles) or drones. UAVs provide a wide range of new possibilities and have become a tool that we now use on a daily basis. However, if their use is not controlled, it could entail several risks, which make it necessary to legislate and monitor UAV flights to ensure, inter alia, the security and privacy of all citizens. As a result of this problem, several laws have been passed which seek to regulate their use; however, no proposals have been made with regards to the control of airspace from a technological point of view. This is exactly what we propose in this article: a platform with different modes designed to control UAVs and monitor their status. The features of the proposed platform provide multiple advantages that make the use of UAVs more secure, such as prohibiting UAVs’ access to restricted areas or avoiding collisions between vehicles. The platform has been successfully tested in Salamanca, Spain.

The Use of Drones in Spain: Towards a Platform for Controlling UAVs in Urban Environments

PubMed Central

Bueno De Mata, Federico

2018-01-01

Rapid advances in technology make it necessary to prepare our society in every aspect. Some of the most significant technological developments of the last decade are the UAVs (Unnamed Aerial Vehicles) or drones. UAVs provide a wide range of new possibilities and have become a tool that we now use on a daily basis. However, if their use is not controlled, it could entail several risks, which make it necessary to legislate and monitor UAV flights to ensure, inter alia, the security and privacy of all citizens. As a result of this problem, several laws have been passed which seek to regulate their use; however, no proposals have been made with regards to the control of airspace from a technological point of view. This is exactly what we propose in this article: a platform with different modes designed to control UAVs and monitor their status. The features of the proposed platform provide multiple advantages that make the use of UAVs more secure, such as prohibiting UAVs’ access to restricted areas or avoiding collisions between vehicles. The platform has been successfully tested in Salamanca, Spain. PMID:29751554

Gravitational wave detection in space

NASA Astrophysics Data System (ADS)

Ni, Wei-Tou

Gravitational Wave (GW) detection in space is aimed at low frequency band (100nHz-100mHz) and middle frequency band (100mHz-10Hz). The science goals are the detection of GWs from (i) Supermassive Black Holes; (ii) Extreme-Mass-Ratio Black Hole Inspirals; (iii) Intermediate-Mass Black Holes; (iv) Galactic Compact Binaries and (v) Relic GW Background. In this paper, we present an overview on the sensitivity, orbit design, basic orbit configuration, angular resolution, orbit optimization, deployment, time-delay interferometry (TDI) and payload concept of the current proposed GW detectors in space under study. The detector proposals under study have arm length ranging from 1000km to 1.3 × 109km (8.6AU) including (a) Solar orbiting detectors — (ASTROD Astrodynamical Space Test of Relativity using Optical Devices (ASTROD-GW) optimized for GW detection), Big Bang Observer (BBO), DECi-hertz Interferometer GW Observatory (DECIGO), evolved LISA (e-LISA), Laser Interferometer Space Antenna (LISA), other LISA-type detectors such as ALIA, TAIJI etc. (in Earthlike solar orbits), and Super-ASTROD (in Jupiterlike solar orbits); and (b) Earth orbiting detectors — ASTROD-EM/LAGRANGE, GADFLI/GEOGRAWI/g-LISA, OMEGA and TIANQIN.

Oil and Gas field code master list 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This is the fourteenth annual edition of the Energy Information Administration`s (EIA) Oil and Gas Field Code Master List. It reflects data collected through October 1995 and provides standardized field name spellings and codes for all identified oil and/or gas fields in the US. The Field Code Index, a listing of all field names and the States in which they occur, ordered by field code, has been removed from this year`s publications to reduce printing and postage costs. Complete copies (including the Field Code Index) will be available on the EIA CD-ROM and the EIA World-Wide Web Site. Future editionsmore » of the complete Master List will be available on CD-ROM and other electronic media. There are 57,400 field records in this year`s Oil and Gas Field Code Master List. As it is maintained by EIA, the Master List includes the following: field records for each State and county in which a field resides; field records for each offshore area block in the Gulf of Mexico in which a field resides; field records for each alias field name (see definition of alias below); and fields crossing State boundaries that may be assigned different names by the respective State naming authorities. Taking into consideration the double-counting of fields under such circumstances, EIA identifies 46,312 distinct fields in the US as of October 1995. This count includes fields that no longer produce oil or gas, and 383 fields used in whole or in part for oil or gas Storage. 11 figs., 6 tabs.« less

River capture and sediment redistribution in northern Tunisia: The doom of Utica

NASA Astrophysics Data System (ADS)

Booth-Rea, Guillermo; Camafort, Miquel; Pérez-Peña, J. Vicente; Melki, Fetheddine; Ranero, César; Azañón, José Miguel; Gracia, Eulalia; Ouadday, Mohamed

2016-04-01

Utica was a flourishing port city in northern Tunisia since the Phoenician times, 12-9th century B.C., until the 4th century A.D.. However, at present it is located 10 km from the coastline after very fast late Holocene progradation of the Mejerda River delta into the bay of Utica. This fast delta progradation occurred after Mejerda River captured Tine River increasing 140 % the river catchment area. Charcoal fragments present in the youngest Tine river terrace at the wind gap give a conventional radiocarbon age of 3240 +/- 30yr BP, indicating that the capture occurred after this date. Quaternary fluvial terraces located in the Tine River paleovalley have been folded and uplifted above a fold related to the active El Alia Tebousouk reverse fault (ETF). Continued uplift of the Tine River valley above the ETF favoured headward erosion of the Medjerda river tributaries creating a transverse drainage that captured Tine River. This capture produced an important change in sediment discharge along the northern Tunisia coast driving sediments to the Gulf of Tunis instead of feeding the Tyrrhenian Sea through the Ichkeul and Bizerte lakes. Although anthropogenic derived degradation of northern Tunisia land for agricultural purposes probably influenced the increase in sediment into the Utica bay, the main cause of rapid progradation of the Medjerda River delta during the late Holocene is related to its increase in drainage area after capturing the Tine River. This process was mostly driven by local contractive tectonics linked to the seismogenic Alia Tebousouk reverse fault.

Toward Topology Dualism: Improving the Accuracy of AS Annotations for Routers

NASA Astrophysics Data System (ADS)

Huffaker, Bradley; Dhamdhere, Amogh; Fomenkov, Marina; Claffy, Kc

To describe, analyze, and model the topological and structural characteristics of the Internet, researchers use Internet maps constructed at the router or autonomous system (AS) level. Although progress has been made on each front individually, a dual graph representing connectivity of routers with AS labels remains an elusive goal. We take steps toward merging the router-level and AS-level views of the Internet. We start from a collection of traces, i.e. sequences of IP addresses obtained with large-scale traceroute measurements from a distributed set of vantage points. We use state-of-the-art alias resolution techniques to identify interfaces belonging to the same router. We develop novel heuristics to assign routers to ASes, producing an AS-router dual graph. We validate our router assignment heuristics using data provided by tier-1 and tier-2 ISPs and five research networks, and show that we successfully assign 80% of routers with interfaces from multiple ASes to the correct AS. When we include routers with interfaces from a single AS, the accuracy drops to 71%, due to the 24% of total inferred routers for which our measurement or alias resolution fails to find an interface belonging to the correct AS. We use our dual graph construct to estimate economic properties of the AS-router dual graph, such as the number of internal and border routers owned by different types of ASes. We also demonstrate how our techniques can improve IP-AS mapping, including resolving up to 62% of false loops we observed in AS paths derived from traceroutes.

Justice Delayed

PubMed Central

2017-01-01

Abstract Tens of thousands of women were coercively sterilized in Czechoslovakia and its successor states. Romani women were particularly targeted for these measures. These practices stopped only in 2004, as a result of international pressure. Although some measures have been taken to ensure that these practices are not repeated, to date neither the Czech Republic nor Slovakia have completed the work of providing effective remedy to victims, as is their right. This article focusses on efforts in the Czech Republic. It concludes that, inter alia, an administrative mechanism is needed to provide financial compensation to victims, since the road to remedy via courts is effectively blocked. PMID:29302159

Revolution in nuclear detection affairs

NASA Astrophysics Data System (ADS)

Stern, Warren M.

2014-05-01

The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

The Navy’s Coupled Atmosphere-Ocean-Wave Prediction System

DTIC Science & Technology

2011-04-15

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Sponsor gnomonici di 2000 anni fa nelle Dolomiti e a Pompei

NASA Astrophysics Data System (ADS)

del Favero, Enrico

2003-01-01

The author describes two memorial tablets of the Roman age, probably dating back to the first Century AD, which were discovered in Belluno province, in the towns of Valle di Cadore and Castellavazzo. They are concerned with sundials donated to the local communities by coeval sponsors. After brief recalling how people measured the time during the Roman age, the meaning of a similar tablet found in Pompeii is examined. This last tablet is included - inter alia - in the Michael T. Bragg's website on Pompeii, which has been found thanks to the so-called Roth's sundials list.

Cryptococcus friedmannii, a new species of yeast from the Antarctic

NASA Technical Reports Server (NTRS)

Vishniac, H. S.

1985-01-01

Cryptococcus friedmannii Vishniac sp. nov. from an Antarctic cryptoendolithic community is a psychrophilic basidioblastomycete characterized by cream-colored colonies of cells with smooth, layered walls, budding monopolarly, producing amylose and extracellular proteinase, utilizing nitrate and D-alanine (inter alia) as nitrogen sources and L-arabinose, arbutin, cellobiose, D-glucuronate, maltose, melezitose, salicin, soluble starch, trehalose, and D-xylose as carbon sources. This species differs from all other basidiomycetous yeasts in possessing the following combination of characters: amylose production (positive), assimilation of cellobiose (positive), D-galactose (negative), myo-inositol (negative), D-mannitol (negative), and sucrose (negative).

The impact of 14-nm photomask uncertainties on computational lithography solutions

NASA Astrophysics Data System (ADS)

Sturtevant, John; Tejnil, Edita; Lin, Tim; Schultze, Steffen; Buck, Peter; Kalk, Franklin; Nakagawa, Kent; Ning, Guoxiang; Ackmann, Paul; Gans, Fritz; Buergel, Christian

2013-04-01

Computational lithography solutions rely upon accurate process models to faithfully represent the imaging system output for a defined set of process and design inputs. These models, which must balance accuracy demands with simulation runtime boundary conditions, rely upon the accurate representation of multiple parameters associated with the scanner and the photomask. While certain system input variables, such as scanner numerical aperture, can be empirically tuned to wafer CD data over a small range around the presumed set point, it can be dangerous to do so since CD errors can alias across multiple input variables. Therefore, many input variables for simulation are based upon designed or recipe-requested values or independent measurements. It is known, however, that certain measurement methodologies, while precise, can have significant inaccuracies. Additionally, there are known errors associated with the representation of certain system parameters. With shrinking total CD control budgets, appropriate accounting for all sources of error becomes more important, and the cumulative consequence of input errors to the computational lithography model can become significant. In this work, we examine with a simulation sensitivity study, the impact of errors in the representation of photomask properties including CD bias, corner rounding, refractive index, thickness, and sidewall angle. The factors that are most critical to be accurately represented in the model are cataloged. CD Bias values are based on state of the art mask manufacturing data and other variables changes are speculated, highlighting the need for improved metrology and awareness.

RADIAL VELOCITY PLANETS DE-ALIASED: A NEW, SHORT PERIOD FOR SUPER-EARTH 55 Cnc e

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dawson, Rebekah I.; Fabrycky, Daniel C., E-mail: rdawson@cfa.harvard.ed, E-mail: daniel.fabrycky@gmail.co

2010-10-10

Radial velocity measurements of stellar reflex motion have revealed many extrasolar planets, but gaps in the observations produce aliases, spurious frequencies that are frequently confused with the planets' orbital frequencies. In the case of Gl 581 d, the distinction between an alias and the true frequency was the distinction between a frozen, dead planet and a planet possibly hospitable to life. To improve the characterization of planetary systems, we describe how aliases originate and present a new approach for distinguishing between orbital frequencies and their aliases. Our approach harnesses features in the spectral window function to compare the amplitude andmore » phase of predicted aliases with peaks present in the data. We apply it to confirm prior alias distinctions for the planets GJ 876 d and HD 75898 b. We find that the true periods of Gl 581 d and HD 73526 b/c remain ambiguous. We revise the periods of HD 156668 b and 55 Cnc e, which were afflicted by daily aliases. For HD 156668 b, the correct period is 1.2699 days and the minimum mass is (3.1 {+-} 0.4) M{sub +}. For 55 Cnc e, the correct period is 0.7365 days-the shortest of any known planet-and the minimum mass is (8.3 {+-} 0.3) M{sub +}. This revision produces a significantly improved five-planet Keplerian fit for 55 Cnc, and a self-consistent dynamical fit describes the data just as well. As radial velocity techniques push to ever-smaller planets, often found in systems of multiple planets, distinguishing true periods from aliases will become increasingly important.« less

Subdaily alias and draconitic errors in the IGS orbits

NASA Astrophysics Data System (ADS)

Griffiths, J.; Ray, J.

2011-12-01

Harmonic signals with a fundamental period near the GPS draconitic year (351.2 d) and overtones up to the 8th multiple have been observed in the power spectra of nearly all products of the International GNSS Service (IGS), including station position time series [Ray et al., 2008; Collilieux et al., 2007; Santamaría-Gómez et al., 2011], apparent geocenter motions [Hugentobler et al., 2008], and orbit jumps between successive days and midnight discontinuities in Earth orientation parameter (EOP) rates [Ray and Griffiths, 2009]. Ray et al. [2008] suggested two mechanisms for the harmonics: mismodeling of orbit dynamics and aliasing of near-sidereal local station multipath effects. King and Watson [2010] have studied the propagation of local multipath errors into draconitic position variations, but orbit-related processes have been less well examined. Here we elaborate our earlier analysis of GPS orbit jumps [Griffiths and Ray, 2009; Gendt et al., 2010] where we observed some draconitic features as well as prominent spectral bands near 29, 14, 9, and 7 d periods. Finer structures within the sub-seasonal bands fall close to the expected alias frequencies of subdaily EOP tide lines but do not coincide precisely. While once-per-rev empirical orbit parameters should strongly absorb any subdaily EOP tide errors due to near-resonance of their respective periods, the observed differences require explanation. This has been done by simulating known EOP tidal errors and checking their impact on a long series of daily GPS orbits. Indeed, simulated tidal aliases are found to be very similar to the observed orbital features in the sub-seasonal bands. Moreover and unexpectedly, some low draconitic harmonics were also stimulated, potentially a source for the widespread errors in most IGS products.

ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy.

PubMed

Bystry, Vojtech; Agathangelidis, Andreas; Bikos, Vasilis; Sutton, Lesley Ann; Baliakas, Panagiotis; Hadzidimitriou, Anastasia; Stamatopoulos, Kostas; Darzentas, Nikos

2015-12-01

An ever-increasing body of evidence supports the importance of B cell receptor immunoglobulin (BcR IG) sequence restriction, alias stereotypy, in chronic lymphocytic leukemia (CLL). This phenomenon accounts for ∼30% of studied cases, one in eight of which belong to major subsets, and extends beyond restricted sequence patterns to shared biologic and clinical characteristics and, generally, outcome. Thus, the robust assignment of new cases to major CLL subsets is a critical, and yet unmet, requirement. We introduce a novel application, ARResT/AssignSubsets, which enables the robust assignment of BcR IG sequences from CLL patients to major stereotyped subsets. ARResT/AssignSubsets uniquely combines expert immunogenetic sequence annotation from IMGT/V-QUEST with curation to safeguard quality, statistical modeling of sequence features from more than 7500 CLL patients, and results from multiple perspectives to allow for both objective and subjective assessment. We validated our approach on the learning set, and evaluated its real-world applicability on a new representative dataset comprising 459 sequences from a single institution. ARResT/AssignSubsets is freely available on the web at http://bat.infspire.org/arrest/assignsubsets/ nikos.darzentas@gmail.com. Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Revolution in Detection Affairs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stern W.

The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovativemore » application of anomaly detection algorithms.« less

Revolution in nuclear detection affairs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stern, Warren M.

The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovativemore » application of anomaly detection algorithms.« less

Electrowetting of soap bubbles

NASA Astrophysics Data System (ADS)

Arscott, Steve

2013-07-01

A proof-of-concept demonstration of the electrowetting-on-dielectric of a sessile soap bubble is reported here. The bubbles are generated using a commercial soap bubble mixture—the surfaces are composed of highly doped, commercial silicon wafers covered with nanometer thick films of Teflon®. Voltages less than 40 V are sufficient to observe the modification of the bubble shape and the apparent bubble contact angle. Such observations open the way to inter alia the possibility of bubble-transport, as opposed to droplet-transport, in fluidic microsystems (e.g., laboratory-on-a-chip)—the potential gains in terms of volume, speed, and surface/volume ratio are non-negligible.

The History of Neurosurgery at the National Hospital, Queen Square, London, with Some Personal Recollections from 1948 Onwards: The Early Years.

PubMed

Powell, Michael P

2017-07-01

The National Hospital, Queen Square, London was founded as a charitable institution in 1860, becoming the first dedicated neuroscience hospital in the world. Sir Victor Horsley, the first neurosurgeon was appointed in 1886, and since that time, Queen Square neurosurgeons have been prominent on the World neurosurgical stage, including Sir Wylie McKissock and Prof Lindsay Symon, inter alia. This article gives the history taken from both published records and personal stories, recorded by a neurosurgeon who has worked at the hospital for thirty five years. Copyright © 2017 Elsevier Inc. All rights reserved.

The implications of the Human Rights Act 1998 for the removal and detention of persons in need of care and attention.

PubMed

Hewitt, D

2002-03-01

The Human Rights Act 1998 ('HRA 1998') requires public authorities to act compatibly with the European Convention on Human Rights ('ECHR'). The ECHR contains rights, inter alia, to liberty and to respect for private life. Those rights--and, therefore, the HRA 1998--may be breached by provisions in the National Assistance Act 1948 and the National Assistance (Amendment) Act 1951 that enable persons in need of care and attention to be removed compulsorily to hospital. However, legal proceedings brought against a public authority that invoked its statuatory powers of removal may themselves be defensible under the HRA.

Verification of the SENTINEL-4 Focal Plane Subsystem

NASA Astrophysics Data System (ADS)

Williges, C.; Hohn, R.; Rossmann, H.; Hilbert, S.; Uhlig, M.; Buchwinkler, K.; Reulke, R.

2017-05-01

The Sentinel-4 payload is a multi-spectral camera system which is designed to monitor atmospheric conditions over Europe. The German Aerospace Center (DLR) in Berlin, Germany conducted the verification campaign of the Focal Plane Subsystem (FPS) on behalf of Airbus Defense and Space GmbH, Ottobrunn, Germany. The FPS consists, inter alia, of two Focal Plane Assemblies (FPAs), one for the UV-VIS spectral range (305 nm … 500 nm), the second for NIR (750 nm … 775 nm). In this publication, we will present in detail the opto-mechanical laboratory set-up of the verification campaign of the Sentinel-4 Qualification Model (QM) which will also be used for the upcoming Flight Model (FM) verification. The test campaign consists mainly of radiometric tests performed with an integrating sphere as homogenous light source. The FPAs have mainly to be operated at 215 K ± 5 K, making it necessary to exploit a thermal vacuum chamber (TVC) for the test accomplishment. This publication focuses on the challenge to remotely illuminate both Sentinel-4 detectors as well as a reference detector homogeneously over a distance of approximately 1 m from outside the TVC. Furthermore selected test analyses and results will be presented, showing that the Sentinel-4 FPS meets specifications.

A new algorithm for design, operation and cost assessment of struvite (MgNH4PO4) precipitation processes.

PubMed

Birnhack, Liat; Nir, Oded; Telzhenski, Marina; Lahav, Ori

2015-01-01

Deliberate struvite (MgNH4PO4) precipitation from wastewater streams has been the topic of extensive research in the last two decades and is expected to gather worldwide momentum in the near future as a P-reuse technique. A wide range of operational alternatives has been reported for struvite precipitation, including the application of various Mg(II) sources, two pH elevation techniques and several Mg:P ratios and pH values. The choice of each operational parameter within the struvite precipitation process affects process efficiency, the overall cost and also the choice of other operational parameters. Thus, a comprehensive simulation program that takes all these parameters into account is essential for process design. This paper introduces a systematic decision-supporting tool which accepts a wide range of possible operational parameters, including unconventional Mg(II) sources (i.e. seawater and seawater nanofiltration brines). The study is supplied with a free-of-charge computerized tool (http://tx.technion.ac.il/~agrengn/agr/Struvite_Program.zip) which links two computer platforms (Python and PHREEQC) for executing thermodynamic calculations according to predefined kinetic considerations. The model can be (inter alia) used for optimizing the struvite-fluidized bed reactor process operation with respect to P removal efficiency, struvite purity and economic feasibility of the chosen alternative. The paper describes the algorithm and its underlying assumptions, and shows results (i.e. effluent water quality, cost breakdown and P removal efficiency) of several case studies consisting of typical wastewaters treated at various operational conditions.

Tourism and Water: Themes of the Alpine Convention

NASA Astrophysics Data System (ADS)

Imhof, R.

2012-04-01

1) The contribution reflects the personal opinion of the author and does not necessarily reflect the point of view of the Permanent Secretariat. The Alpine Convention is a multilateral framework treaty signed in 1991 by the eight states of the Alpine bow as well as the European Community. Its main objectives are the sustainable development of the Alpine territory and the safeguarding of the interests of the people living within it, embracing the environmental, social and economic dimensions in the broadest sense. In order to achieve its objectives, over the years the Framework Convention has been equipped with a large number of thematic protocols, e.g. on tourism. The overall objective of the Protocol on Tourism, which first came into force in 2002, is to contribute to sustainable development in the Alpine region within the existing institutional framework, by encouraging environmentally-friendly tourism through specific measures and recommendations which take the interests of both the local population and tourists into account. The provisions of the Protocol on Tourism primarily concern tourism management and controlling tourist flows, structural developments such as ski lifts and ski slopes, accommodation and the balanced development of economically weak areas. Guidelines, development plans, sectoral plans have to be adopted at the appropriate territorial level in order to enable to assess the impact of tourism development on, inter alia, water. This extends also to ski slopes developments. For example the production of artificial snow production may be authorized only if the location's hydrological, climatic and ecological conditions allow. Water is listed among the twelve themes in relation to which the Contracting Parties are supposed to take measures and coordinate their policies (Article 2 of the Framework Convention). The Alpine Convention aims to preserve and re-establish healthy water systems, especially keeping waters clean and protecting the natural environment. This needs to be accomplished by balancing the local population's interests with environmental needs. Water is considered as a crucial element for different uses such as hydroelectricity production, irrigation or drinking water as well as in biotopes, especially forests, environmental regeneration and diversity and in natural and cultural landscapes features. Aspects of water protection can be found in the protocols on Energy, Nature Conservation and Landscape Protection, Soil Protection, Tourism, Spatial Planning and Sustainable Development, Mountain Agriculture, Mountain Forests and Transport. However a specific protocol on water is not in place. The Reports on the state of the Alps are published regularly by the Alpine Conference. In November 2006 water was chosen as the topic for the second Report on the State of the Alps. The report compiles information from the Alpine Countries on monitoring programmes, chemical quality of water (point sources, diffuse sources and the chemical status of surface and groundwater in the Alps), water abstraction, residual water and hydro-peaking, droughts and water scarcity, reservoirs and regulated lakes as well on river morphology and continuity. Finally, it summarizes information on property rights and provisions for access to water in the different countries, charges regarding the use of water, different management systems for water supply (public or private), hydro power generation in the Alps and water use management conflicts. The Report was adopted by the Ministers during the Xth Alpine Conference in Evian (France) in 2009. This Conference additionally set up a platform on Water management in the Alpine area in order to deal continually with the theme of water in the Alps. Within this platform, objectives that were identified in the second Report on the State of the Alps should be pursued and examples of good practices exchanged. The platform developed inter alia common guidelines for the use of small hydropower in the Alpine region, which were adopted by the XIth Alpine Conference in Brdo (Slovenia) in 2011. Next tasks for the water platform and follow up will be identified at the XIIth Alpine Conference in September 2012 in Poschiavo, Switzerland. Further, at this conference the fourth Report on the State of the Alps on "Sustainable tourism in the Alps" should be adopted as well.

Iterative and variational homogenization methods for filled elastomers

NASA Astrophysics Data System (ADS)

Goudarzi, Taha

Elastomeric composites have increasingly proved invaluable in commercial technological applications due to their unique mechanical properties, especially their ability to undergo large reversible deformation in response to a variety of stimuli (e.g., mechanical forces, electric and magnetic fields, changes in temperature). Modern advances in organic materials science have revealed that elastomeric composites hold also tremendous potential to enable new high-end technologies, especially as the next generation of sensors and actuators featured by their low cost together with their biocompatibility, and processability into arbitrary shapes. This potential calls for an in-depth investigation of the macroscopic mechanical/physical behavior of elastomeric composites directly in terms of their microscopic behavior with the objective of creating the knowledge base needed to guide their bottom-up design. The purpose of this thesis is to generate a mathematical framework to describe, explain, and predict the macroscopic nonlinear elastic behavior of filled elastomers, arguably the most prominent class of elastomeric composites, directly in terms of the behavior of their constituents --- i.e., the elastomeric matrix and the filler particles --- and their microstructure --- i.e., the content, size, shape, and spatial distribution of the filler particles. This will be accomplished via a combination of novel iterative and variational homogenization techniques capable of accounting for interphasial phenomena and finite deformations. Exact and approximate analytical solutions for the fundamental nonlinear elastic response of dilute suspensions of rigid spherical particles (either firmly bonded or bonded through finite size interphases) in Gaussian rubber are first generated. These results are in turn utilized to construct approximate solutions for the nonlinear elastic response of non-Gaussian elastomers filled with a random distribution of rigid particles (again, either firmly bonded or bonded through finite size interphases) at finite concentrations. Three-dimensional finite element simulations are also carried out to gain further insight into the proposed theoretical solutions. Inter alia, we make use of these solutions to examine the effects of particle concentration, mono- and poly-dispersity of the filler particle size, and the presence of finite size interphases on the macroscopic response of filled elastomers. The solutions are found able to explain and describe experimental results that to date have been understood only in part. More generally, the solutions provide a robust tool to efficiently guide the design of filled elastomers with desired macroscopic properties. The homogenization techniques developed in this work are not limited to nonlinear elasticity, but can be readily utilized to study multi-functional properties as well. For demonstration purposes, we work out a novel exact solution for the macroscopic dielectric response of filled elastomers with interphasial space charges.

Maximum power point tracker for photovoltaic power plants

NASA Astrophysics Data System (ADS)

Arcidiacono, V.; Corsi, S.; Lambri, L.

The paper describes two different closed-loop control criteria for the maximum power point tracking of the voltage-current characteristic of a photovoltaic generator. The two criteria are discussed and compared, inter alia, with regard to the setting-up problems that they pose. Although a detailed analysis is not embarked upon, the paper also provides some quantitative information on the energy advantages obtained by using electronic maximum power point tracking systems, as compared with the situation in which the point of operation of the photovoltaic generator is not controlled at all. Lastly, the paper presents two high-efficiency MPPT converters for experimental photovoltaic plants of the stand-alone and the grid-interconnected type.

From rum jungle to Wismut-reducing the environmental impact of uranium mining and milling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zuk, W.M.; Jeffree, R.A.; Levins, D.M.

1994-12-31

Australia has a long history of uranium mining. In the early days, little attention was given to environmental matters and considerable pollution occurred. Ansto has been involved in rehabilitation of a number of the early uranium mining sites, from Rum Jungle in Australia`s Northern Territory to Wismut in Germany, and is working with current producers to minimise the environmental impact of their operations. Ansto`s expertise is extensive and includes, inter alia, amelioration of acid mine drainage, radon measurement and control, treatment of mill wastes, management of tailings, monitoring of seepage plumes, mathematical modelling of pollutant transport and biological impacts inmore » a tropical environment.« less

The Effect of Power Protection Equipment on Explosion Hazards and on the Reliability of Power Supply to Longwall Systems

NASA Astrophysics Data System (ADS)

Boron, Sergiusz

2017-06-01

Operational safety of electrical machines and equipment depends, inter alia, on the hazards resulting from their use and on the scope of applied protective measures. The use of insufficient protection against existing hazards leads to reduced operational safety, particularly under fault conditions. On the other hand, excessive (in relation to existing hazards) level of protection may compromise the reliability of power supply. This paper analyses the explosion hazard created by earth faults in longwall power supply systems and evaluates existing protection equipment from the viewpoint of its protective performance, particularly in the context of explosion hazards, and also assesses its effect on the reliability of power supply.

International perspectives on food safety and regulations - a need for harmonized regulations: perspectives in China.

PubMed

Liu, Xiumei

2014-08-01

Food safety is a major livelihood issue and a priority concern in China. Since the Food Safety Law of the People's Republic of China was issued in 2009, the food safety control system has been strengthened through, inter alia, the Food Safety Risk Surveillance System, the Food Safety Risk Assessment System and the Food Safety Standards System. In accordance with the Food Safety Law and regulations for implementation, the Ministry of Health released the 'Twelfth Five-year Plan' of Food Safety Standards. The existing 5000 food-related standards will be integrated. Notwithstanding, the supervision system in China needs to be further improved and strengthened. © 2014 Society of Chemical Industry.

Arctic Ocean Tides from GRACE Satellite Accelerations

NASA Astrophysics Data System (ADS)

Killett, B.; Wahr, J. M.; Desai, S. D.; Yuan, D.; Watkins, M. M.

2010-12-01

Because missions such as TOPEX/POSEIDON don't extend to high latitudes, Arctic ocean tidal solutions aren't constrained by altimetry data. The resulting errors in tidal models alias into monthly GRACE gravity field solutions at all latitudes. Fortunately, GRACE inter-satellite ranging data can be used to solve for these tides directly. Seven years of GRACE inter-satellite acceleration data are inverted using a mascon approach to solve for residual amplitudes and phases of major solar and lunar tides in the Arctic ocean relative to FES 2004. Simulations are performed to test the inversion algorithm's performance, and uncertainty estimates are derived from the tidal signal over land. Truncation error magnitudes and patterns are compared to the residual tidal signals.

Modelling catchment hydrological responses in a Himalayan Lake as a function of changing land use and land cover

NASA Astrophysics Data System (ADS)

Badar, Bazigha; Romshoo, Shakil A.; Khan, M. A.

2013-04-01

In this paper, we evaluate the impact of changing land use/land cover (LULC) on the hydrological processes in Dal lake catchment of Kashmir Himalayas by integrating remote sensing, simulation modelling and extensive field observations. Over the years, various anthropogenic pressures in the lake catchment have significantly altered the land system, impairing, inter-alia, sustained biotic communities and water quality of the lake. The primary objective of this paper was to help a better understanding of the LULC change, its driving forces and the overall impact on the hydrological response patterns. Multi-sensor and multi-temporal satellite data for 1992 and 2005 was used for determining the spatio-temporal dynamics of the lake catchment. Geographic Information System (GIS) based simulation model namely Generalized Watershed Loading Function (GWLF) was used to model the hydrological processes under the LULC conditions. We discuss spatio-temporal variations in LULC and identify factors contributing to these variations and analyze the corresponding impacts of the change on the hydrological processes like runoff, erosion and sedimentation. The simulated results on the hydrological responses reveal that depletion of the vegetation cover in the study area and increase in impervious and bare surface cover due to anthropogenic interventions are the primary reasons for the increased runoff, erosion and sediment discharges in the Dal lake catchment. This study concludes that LULC change in the catchment is a major concern that has disrupted the ecological stability and functioning of the Dal lake ecosystem.

Network Information System

DOE Office of Scientific and Technical Information (OSTI.GOV)

1996-05-01

The Network Information System (NWIS) was initially implemented in May 1996 as a system in which computing devices could be recorded so that unique names could be generated for each device. Since then the system has grown to be an enterprise wide information system which is integrated with other systems to provide the seamless flow of data through the enterprise. The system Iracks data for two main entities: people and computing devices. The following are the type of functions performed by NWIS for these two entities: People Provides source information to the enterprise person data repository for select contractors andmore » visitors Generates and tracks unique usernames and Unix user IDs for every individual granted cyber access Tracks accounts for centrally managed computing resources, and monitors and controls the reauthorization of the accounts in accordance with the DOE mandated interval Computing Devices Generates unique names for all computing devices registered in the system Tracks the following information for each computing device: manufacturer, make, model, Sandia property number, vendor serial number, operating system and operating system version, owner, device location, amount of memory, amount of disk space, and level of support provided for the machine Tracks the hardware address for network cards Tracks the P address registered to computing devices along with the canonical and alias names for each address Updates the Dynamic Domain Name Service (DDNS) for canonical and alias names Creates the configuration files for DHCP to control the DHCP ranges and allow access to only properly registered computers Tracks and monitors classified security plans for stand-alone computers Tracks the configuration requirements used to setup the machine Tracks the roles people have on machines (system administrator, administrative access, user, etc...) Allows systems administrators to track changes made on the machine (both hardware and software) Generates an adjustment history of changes on selected fields« less

A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device.

PubMed

Harrison, Christine J; Griffiths, Mike; Moorman, Fìona; Schnittger, Susanne; Cayuela, Jean-Michel; Shurtleff, Sheila; Gottardi, Enrico; Mitterbauer, Gerlinde; Colomer, Dolores; Delabesse, Eric; Castéras, Vincent; Maroc, Nicolas

2007-02-01

Rearrangements of the MLL gene are significant in acute leukemia. Among the most frequent translocations are t(4;11)(q21;q23) and t(9;11)(p22;q23), which give rise to the MLL-AFF1 and MLL-MLLT3 fusion genes (alias MLL-AF4 and MLL-AF9) in acute lymphoblastic and acute myeloid leukemia, respectively. Current evidence suggests that determining the MLL status of acute leukemia, including precise identification of the partner gene, is important in defining appropriate treatment. This underscores the need for accurate detection methods. A novel molecular diagnostic device, the MLL FusionChip, has been successfully used to identify MLL fusion gene translocations in acute leukemia, including the precise breakpoint location. This study evaluated the performance of the MLL FusionChip within a routine clinical environment, comprising nine centers worldwide, in the analysis of 21 control and 136 patient samples. It was shown that the assay allowed accurate detection of the MLL fusion gene, regardless of the breakpoint location, and confirmed that this multiplex approach was robust in a global multicenter trial. The MLL FusionChip was shown to be superior to other detection methods. The type of molecular information provided by MLL FusionChip gave an indication of the appropriate primers to design for disease monitoring of MLL patients following treatment.

IS-EPOS - a prototype of EPOS Thematic Core Service for seismic processes induced by human operations

NASA Astrophysics Data System (ADS)

Orlecka-Sikora, Beata; Lasocki, Stanislaw; Leptokaropoulos, Konstantinos

2014-05-01

The community focused on seismic processes induced by human operations has been organized within EPOS Integration Program as Working Group 10 Infrastructure for Georesources. This group has brought together representatives from the scientific community and industry from 13 European countries. WG10 aims to integrate the research infrastructure (RI) in the area of seismicity induced (IS) by human activity: tremors and rockbursts in underground mines, seismicity associated with conventional and unconventional oil and gas production, induced by geothermal energy extraction and by underground reposition and storage of liquids (e.g. water disposal associated with energy extraction) and gases (CO2 sequestration, inter alia) and triggered by filling surface water reservoirs, etc. WG10 priority is to create new research opportunities in the field responding to global challenges connected with exploitation of georesources. WG10 has prepared the model of integration fulfilling the scientific mission and raising the visibility of stakeholders. The end-state Induced Seismicity Thematic Core Service (IS TCS) has been designed together with key metrics for TCS benefits in four areas: scientific, societal, economic and capacity building. IS-EPOS project, funded by National Centre for Research and Development, Poland within the program "Innovative Economy Operational Program Priority Axis 2 - R&D Infrastructure", aims at building a prototype of IS TCS. The prototype will implement fully the designed logic of IS TCS. Research infrastructure integrated within the prototype will comprise altogether seven comprehensive data cases of seismicity linked to deep mining related, associating geothermal production and triggered by reservoir impoundment. The implemented thematic services will enable studies within the use-case "Clustering of induced earthquakes". The IS TCS prototype is expected to reach full functionality by the end of 2014.

JRC GMO-Amplicons: a collection of nucleic acid sequences related to genetically modified organisms

PubMed Central

Petrillo, Mauro; Angers-Loustau, Alexandre; Henriksson, Peter; Bonfini, Laura; Patak, Alex; Kreysa, Joachim

2015-01-01

The DNA target sequence is the key element in designing detection methods for genetically modified organisms (GMOs). Unfortunately this information is frequently lacking, especially for unauthorized GMOs. In addition, patent sequences are generally poorly annotated, buried in complex and extensive documentation and hard to link to the corresponding GM event. Here, we present the JRC GMO-Amplicons, a database of amplicons collected by screening public nucleotide sequence databanks by in silico determination of PCR amplification with reference methods for GMO analysis. The European Union Reference Laboratory for Genetically Modified Food and Feed (EU-RL GMFF) provides these methods in the GMOMETHODS database to support enforcement of EU legislation and GM food/feed control. The JRC GMO-Amplicons database is composed of more than 240 000 amplicons, which can be easily accessed and screened through a web interface. To our knowledge, this is the first attempt at pooling and collecting publicly available sequences related to GMOs in food and feed. The JRC GMO-Amplicons supports control laboratories in the design and assessment of GMO methods, providing inter-alia in silico prediction of primers specificity and GM targets coverage. The new tool can assist the laboratories in the analysis of complex issues, such as the detection and identification of unauthorized GMOs. Notably, the JRC GMO-Amplicons database allows the retrieval and characterization of GMO-related sequences included in patents documentation. Finally, it can help annotating poorly described GM sequences and identifying new relevant GMO-related sequences in public databases. The JRC GMO-Amplicons is freely accessible through a web-based portal that is hosted on the EU-RL GMFF website. Database URL: http://gmo-crl.jrc.ec.europa.eu/jrcgmoamplicons/ PMID:26424080

JRC GMO-Amplicons: a collection of nucleic acid sequences related to genetically modified organisms.

PubMed

Petrillo, Mauro; Angers-Loustau, Alexandre; Henriksson, Peter; Bonfini, Laura; Patak, Alex; Kreysa, Joachim

2015-01-01

The DNA target sequence is the key element in designing detection methods for genetically modified organisms (GMOs). Unfortunately this information is frequently lacking, especially for unauthorized GMOs. In addition, patent sequences are generally poorly annotated, buried in complex and extensive documentation and hard to link to the corresponding GM event. Here, we present the JRC GMO-Amplicons, a database of amplicons collected by screening public nucleotide sequence databanks by in silico determination of PCR amplification with reference methods for GMO analysis. The European Union Reference Laboratory for Genetically Modified Food and Feed (EU-RL GMFF) provides these methods in the GMOMETHODS database to support enforcement of EU legislation and GM food/feed control. The JRC GMO-Amplicons database is composed of more than 240 000 amplicons, which can be easily accessed and screened through a web interface. To our knowledge, this is the first attempt at pooling and collecting publicly available sequences related to GMOs in food and feed. The JRC GMO-Amplicons supports control laboratories in the design and assessment of GMO methods, providing inter-alia in silico prediction of primers specificity and GM targets coverage. The new tool can assist the laboratories in the analysis of complex issues, such as the detection and identification of unauthorized GMOs. Notably, the JRC GMO-Amplicons database allows the retrieval and characterization of GMO-related sequences included in patents documentation. Finally, it can help annotating poorly described GM sequences and identifying new relevant GMO-related sequences in public databases. The JRC GMO-Amplicons is freely accessible through a web-based portal that is hosted on the EU-RL GMFF website. Database URL: http://gmo-crl.jrc.ec.europa.eu/jrcgmoamplicons/. © The Author(s) 2015. Published by Oxford University Press.

Extremely Large Telescope Project Selected in ESFRI Roadmap

NASA Astrophysics Data System (ADS)

2006-10-01

In its first Roadmap, the European Strategy Forum on Research Infrastructures (ESFRI) choose the European Extremely Large Telescope (ELT), for which ESO is presently developing a Reference Design, as one of the large scale projects to be conducted in astronomy, and the only one in optical astronomy. The aim of the ELT project is to build before the end of the next decade an optical/near-infrared telescope with a diameter in the 30-60m range. ESO PR Photo 40/06 The ESFRI Roadmap states: "Extremely Large Telescopes are seen world-wide as one of the highest priorities in ground-based astronomy. They will vastly advance astrophysical knowledge allowing detailed studies of inter alia planets around other stars, the first objects in the Universe, super-massive Black Holes, and the nature and distribution of the Dark Matter and Dark Energy which dominate the Universe. The European Extremely Large Telescope project will maintain and reinforce Europe's position at the forefront of astrophysical research." Said Catherine Cesarsky, Director General of ESO: "In 2004, the ESO Council mandated ESO to play a leading role in the development of an ELT for Europe's astronomers. To that end, ESO has undertaken conceptual studies for ELTs and is currently also leading a consortium of European institutes engaged in studying enabling technologies for such a telescope. The inclusion of the ELT in the ESFRI roadmap, together with the comprehensive preparatory work already done, paves the way for the next phase of this exciting project, the design phase." ESO is currently working, in close collaboration with the European astronomical community and the industry, on a baseline design for an Extremely Large Telescope. The plan is a telescope with a primary mirror between 30 and 60 metres in diameter and a financial envelope of about 750 m Euros. It aims at more than a factor ten improvement in overall performance compared to the current leader in ground based astronomy: the ESO Very Large Telescope at the Paranal Observatory. The draft Baseline Reference Design will be presented to the wider scientific community on 29 - 30 November 2006 at a dedicated ELT Workshop Meeting in Marseille (France) and will be further reiterated. The design is then to be presented to the ESO Council at the end of 2006. The goal is to start the detailed E-ELT design work by the first half of 2007. Launched in April 2002, the European Strategy Forum on Research Infrastructures was set-up following a recommendation of the European Union Council, with the role to support a coherent approach to policy-making on research infrastructures in Europe, and to act as an incubator for international negotiations about concrete initiatives. In particular, ESFRI has prepared a European Roadmap identifying new Research Infrastructure of pan-European interest corresponding to the long term needs of the European research communities, covering all scientific areas, regardless of possible location and likely to be realised in the next 10 to 20 years. The Roadmap was presented on 19 October. It is the result of an intensive two-year consultation and peer review process involving over 1000 high level European and international experts. The Roadmap identifies 35 large scale infrastructure projects, at various stages of development, in seven key research areas including Environmental Sciences; Energy; Materials Sciences; Astrophysics, Astronomy, Particle and Nuclear Physics; Biomedical and Life Sciences; Social Sciences and the Humanities; Computation and data Treatment.

[Tobacco or living? Decrease in smoking in Iceland 1985-1990].

PubMed

Blöndal, P; Hardarson, P; Helgason, T; Ragnarsson, J

1991-01-01

In 1985 a new tobacco act was passed in Iceland, which prescribed inter alia that warnings be printed on packages of tobacco goods. A prohibition on advertisement for tobacco has since been imposed; information on the injurious effects of tobacco has been disseminated in the schools and via TV. A law which limits smoking at work places and indoors in public buildings has also been introduced. Smoking habits have changed in the last five years. The number of daily smokers has fallen from 40.0 to 32.5 per cent, and rules concerning smokeless hospitals are coming into force. The authors believe that doctors and hospitals should lead the way if we are to reduce smoking in the society.

Lockwood on human identity and the primitive streak.

PubMed Central

Howsepian, A A

1997-01-01

Michael Lockwood has recently concluded that it can be morally permissible to perform potentially damaging non-therapeutic experiments on live human (pre)embryos. The reasons he provides in support of this conclusion commit him inter alia to the following controversial theses: (i) an organism's potential for twinning bears critically on the identity conditions for that organism; and (ii) functionally intact mentality-mediating neurological structures play a critical role in establishing the identity conditions for human organisms. I argue that Lockwood has given us no good reason to endorse either of these theses and, hence, that he has given us no good reason to believe that it can be morally permissible to perform potentially damaging non-therapeutic experiments on live human (pre)embryos. PMID:9055161

Atmospheric heat engines on earth and Mars

NASA Astrophysics Data System (ADS)

Philip, J. R.

1987-06-01

The character of the earth's atmospheric heat engine depends, inter alia, on the relatively tight linkage between surface fluxes of energy and of H2O. On Mars, on the other hand, H2O-based latent heat fluxes are only a trivial fraction of total surface energy fluxes, and the dominant component of the working fluid is CO2. These considerations are made quantitative through evaluation of Lambda, the equivalent temperature excess at the surface for a particular component of the working fluid. The very different values (and latitudinal distribution) of Lambda on the two planets signalize vividly their different meteorology. Preliminary study of the climatology of Lambda on earth brings out, in particular, the tightness of the H2O-energy linkage in the tropics.

Issues and strategies in the DNA identification of World Trade Center victims.

PubMed

Brenner, C H; Weir, B S

2003-05-01

Identification of the nearly 3000 victims of the World Trade Center attack, represented by about 15,000 body parts, rests heavily on DNA. Reference DNA profiles are often from relatives rather than from the deceased themselves. With so large a set of victims, coincidental similarities between non-relatives abound. Therefore considerable care is necessary to succeed in correlating references with correct victims while avoiding spurious assignments. Typically multiple relatives are necessary to establish the identity of a victim. We describe a 3-stage paradigm--collapse, screen, test--to organize the work of sorting out the identities. Inter alia we present a simple and general formula for the likelihood ratio governing practically any potential relationship between two DNA profiles.

Prominin‐1/CD133: Lipid Raft Association, Detergent Resistance, and Immunodetection

PubMed Central

Karbanová, Jana; Lorico, Aurelio; Bornhäuser, Martin; Fargeas, Christine A.

2017-01-01

Summary The cell surface antigen prominin‐1 (alias CD133) has gained enormous interest in the past 2 decades and given rise to debates as to its utility as a biological stem and cancer stem cell marker. Important and yet often overlooked knowledge that is pertinent to its physiological function has been generated in other systems given its more general expression beyond primitive cells. This article briefly discusses the importance of particular biochemical features of CD133 with relation to its association with membrane microdomains (lipid rafts) and proper immunodetection. It also draws attention toward the adequate use of detergents and caveats that may apply to the interpretation of the results generated. Stem Cells Translational Medicine 2018;7:155–160 PMID:29271118

Numerical analysis of the non-contacting gas face seals

NASA Astrophysics Data System (ADS)

Blasiak, S.

2017-08-01

The non-contacting gas face seals are used in high-performance devices where the main requirements are safety and reliability. Compliance with these requirements is made possible by careful research and analysis of physical processes related to, inter alia, fluid flow through the radial gap and ring oscillations susceptible to being housed in the enclosure under the influence of rotor kinematic forces. Elaborating and developing mathematical models describing these phenomena allows for more and more accurate analysis results. The paper presents results of studies on stationary ring oscillations made of different types of materials. The presented results of the research allow to determine which of the materials used causes the greatest amplitude of the vibration of the system fluid film-working rings.

Multiple-Objective Optimal Designs for Studying the Dose Response Function and Interesting Dose Levels

PubMed Central

Hyun, Seung Won; Wong, Weng Kee

2016-01-01

We construct an optimal design to simultaneously estimate three common interesting features in a dose-finding trial with possibly different emphasis on each feature. These features are (1) the shape of the dose-response curve, (2) the median effective dose and (3) the minimum effective dose level. A main difficulty of this task is that an optimal design for a single objective may not perform well for other objectives. There are optimal designs for dual objectives in the literature but we were unable to find optimal designs for 3 or more objectives to date with a concrete application. A reason for this is that the approach for finding a dual-objective optimal design does not work well for a 3 or more multiple-objective design problem. We propose a method for finding multiple-objective optimal designs that estimate the three features with user-specified higher efficiencies for the more important objectives. We use the flexible 4-parameter logistic model to illustrate the methodology but our approach is applicable to find multiple-objective optimal designs for other types of objectives and models. We also investigate robustness properties of multiple-objective optimal designs to mis-specification in the nominal parameter values and to a variation in the optimality criterion. We also provide computer code for generating tailor made multiple-objective optimal designs. PMID:26565557

Multiple-Objective Optimal Designs for Studying the Dose Response Function and Interesting Dose Levels.

PubMed

Hyun, Seung Won; Wong, Weng Kee

2015-11-01

We construct an optimal design to simultaneously estimate three common interesting features in a dose-finding trial with possibly different emphasis on each feature. These features are (1) the shape of the dose-response curve, (2) the median effective dose and (3) the minimum effective dose level. A main difficulty of this task is that an optimal design for a single objective may not perform well for other objectives. There are optimal designs for dual objectives in the literature but we were unable to find optimal designs for 3 or more objectives to date with a concrete application. A reason for this is that the approach for finding a dual-objective optimal design does not work well for a 3 or more multiple-objective design problem. We propose a method for finding multiple-objective optimal designs that estimate the three features with user-specified higher efficiencies for the more important objectives. We use the flexible 4-parameter logistic model to illustrate the methodology but our approach is applicable to find multiple-objective optimal designs for other types of objectives and models. We also investigate robustness properties of multiple-objective optimal designs to mis-specification in the nominal parameter values and to a variation in the optimality criterion. We also provide computer code for generating tailor made multiple-objective optimal designs.

Integrating ergonomics into engineering design: the role of objects.

PubMed

Hall-Andersen, Lene Bjerg; Broberg, Ole

2014-05-01

The objective of this study was to explore the role of objects in integrating ergonomic knowledge in engineering design processes. An engineering design case was analyzed using the theoretical concepts of boundary objects and intermediary objects: Boundary objects facilitate collaboration between different knowledge domains, while the aim of an intermediary object is to circulate knowledge and thus produce a distant effect. Adjustable layout drawings served as boundary objects and had a positive impact on the dialog between an ergonomist and designers. An ergonomic guideline document was identified as an intermediary object. However, when the ergonomic guidelines were circulated in the design process, only some of the guidelines were transferred to the design of the sterile processing plant. Based on these findings, recommendations for working with objects in design processes are included. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Liberating Learning Object Design from the Learning Style of Student Instructional Designers

ERIC Educational Resources Information Center

Akpinar, Yavuz

2007-01-01

Learning objects are a new form of learning resource, and the design of these digital environments has many facets. To investigate senior instructional design students' use of reflection tools in designing learning objects, a series of studies was conducted using the Reflective Action Instructional Design and Learning Object Review Instrument…

Potential environmental effects of pack stock on meadow ecosystems of the Sierra Nevada, USA

USGS Publications Warehouse

Ostoja, Steven M.; Brooks, Matthew L.; Moore, Peggy E.; Berlow, Eric L.; Robert Blank,; Roche, Jim; Chase, Jennifer T.; Sylvia Haultain,

2014-01-01

Pack and saddle stock, including, but not limited to domesticated horses, mules, and burros, are used to support commercial, private and administrative activities in the Sierra Nevada. The use of pack stock has become a contentious and litigious issue for land management agencies in the region inter alia due to concerns over effects on the environment. The potential environmental effects of pack stock on Sierra Nevada meadow ecosystems are reviewed and it is concluded that the use of pack stock has the potential to influence the following: (1) water nutrient dynamics, sedimentation, temperature, and microbial pathogen content; (2) soil chemistry, nutrient cycling, soil compaction and hydrology; (3) plant individuals, populations and community dynamics, non-native invasive species, and encroachment of woody species; and (4) wildlife individuals, populations and communities. It is considered from currently available information that management objectives of pack stock should include the following: minimise bare ground, maximise plant cover, maintain species composition of native plants, minimise trampling, especially on wet soils and stream banks, and minimise direct urination and defecation by pack stock into water. However, incomplete documentation of patterns of pack stock use and limited past research limits current understanding of the effects of pack stock, especially their effects on water, soils and wildlife. To improve management of pack stock in this region, research is needed on linking measurable monitoring variables (e.g. plant cover) with environmental relevancy (e.g. soil erosion processes, wildlife habitat use), and identifying specific environmental thresholds of degradation along gradients of pack stock use in Sierra Nevada meadows.

GIS4schools: custom-made GIS-applications for educational use

NASA Astrophysics Data System (ADS)

Demharter, Timo; Michel, Ulrich

2013-10-01

From a didactic point of view the procurement and the application of modern geographical methods and functions become more and more important. Although the integration of GIS in the classroom is repeatedly demanded, inter alia in Baden-Württemberg, Germany, the number of GIS users is small in comparison to other European countries or the USA. Possible reasons for this could, for instance, lie in the lack of GIS and computer knowledge of the teachers themselves and the subsequent extensive training effort in Desktop-GIS [1]. Today you have the technological possibilities to provide the broad public with geoinformation and geotechnology: Web technologies offer access to web-based, mobile and local applications through simple gateways. The objective of the project "GIS4schools" is to generate a service-based infrastructure, which can be operated via mobile clients as well as via Desktop-GIS or a Browser. Due to the easy availability of the services the focus is in particular on students. This circumstance is a novelty through which a differentiated approach to the implementation of GIS in schools is established. Accordingly, the pilot nature of this project becomes apparent as well as its greater importance beyond its actual content especially for the sector of media development at colleges of education. The continuity from Web-GIS to Desktop-GIS is innovative: The goal is to create an adapted multi-level solution which allows both, an easy introduction if desired or a detailed analysis - either to be achieved with a focus especially on students and their cooperation among one another.

GIS4schools: a new approach in GIS education

NASA Astrophysics Data System (ADS)

Demharter, Timo; Michel, Ulrich

2012-10-01

From a didactic point of view the procurement and the application of modern geographical methods and functions become more and more important. Although the integration of GIS in the classroom is repeatedly demanded, inter alia in Baden-Württemberg, Germany, the number of GIS users is small in comparison to other European countries or the USA. Possible reasons for this could, for instance, lie in the lack of GIS and computer knowledge of the teachers themselves and the subsequent extensive training effort in Desktop-GIS (KERSKI 2000, SCHLEICHER 2004). Today you have the technological possibilities to provide the broad public with geoinformation and geotechnology: Web technologies offer access to web-based, mobile and local applications through simple gateways. The objective of the project "GIS4schools" is to generate a service-based infrastructure, which can be operated via mobile clients as well as via Desktop-GIS or a Browser. Due to the easy availability of the services the focus is in particular on students. This circumstance is a novelty through which a differentiated approach to the implementation of GIS in schools is established. Accordingly, the pilot nature of this project becomes apparent as well as its greater importance beyond its actual content especially for the sector of media development at colleges of education. The continuity from Web-GIS to Desktop-GIS is innovative: The goal is to create an adapted multi-level solution which allows both, an easy introduction if desired or a detailed analysis - either to be achieved with a focus especially on students and their cooperation among one another.

How well do final year undergraduate medical students master practical clinical skills?

PubMed Central

Störmann, Sylvère; Stankiewicz, Melanie; Raes, Patricia; Berchtold, Christina; Kosanke, Yvonne; Illes, Gabrielle; Loose, Peter; Angstwurm, Matthias W.

2016-01-01

Introduction: The clinical examination and other practical clinical skills are fundamental to guide diagnosis and therapy. The teaching of such practical skills has gained significance through legislative changes and adjustments of the curricula of medical schools in Germany. We sought to find out how well final year undergraduate medical students master practical clinical skills. Methods: We conducted a formative 4-station objective structured clinical examination (OSCE) focused on practical clinical skills during the final year of undergraduate medical education. Participation was voluntary. Besides the examination of heart, lungs, abdomen, vascular system, lymphatic system as well as the neurological, endocrinological or orthopaedic examination we assessed other basic clinical skills (e.g. interpretation of an ECG, reading a chest X-ray). Participants filled-out a questionnaire prior to the exam, inter alia to give an estimate of their performance. Results: 214 final year students participated in our study and achieved a mean score of 72.8% of the total score obtainable. 9.3% of participants (n=20) scored insufficiently (<60%). We found no influence of sex, prior training in healthcare or place of study on performance. Only one third of the students correctly estimated their performance (35.3%), whereas 30.0% and 18.8% over-estimated their performance by 10% and 20% respectively. Discussion: Final year undergraduate medical students demonstrate considerable deficits performing practical clinical skills in the context of a formative assessment. Half of the students over-estimate their own performance. We recommend an institutionalised and frequent assessment of practical clinical skills during undergraduate medical education, especially in the final year. PMID:27579358

Optoelectronic image scanning with high spatial resolution and reconstruction fidelity

NASA Astrophysics Data System (ADS)

Craubner, Siegfried I.

2002-02-01

In imaging systems the detector arrays deliver at the output time-discrete signals, where the spatial frequencies of the object scene are mapped into the electrical signal frequencies. Since the spatial frequency spectrum cannot be bandlimited by the front optics, the usual detector arrays perform a spatial undersampling and as a consequence aliasing occurs. A means to partially suppress the backfolded alias band is bandwidth limitation in the reconstruction low-pass, at the price of resolution loss. By utilizing a bilinear detector array in a pushbroom-type scanner, undersampling and aliasing can be overcome. For modeling the perception, the theory of discrete systems and multirate digital filter banks is applied, where aliasing cancellation and perfect reconstruction play an important role. The discrete transfer function of a bilinear array can be imbedded into the scheme of a second-order filter bank. The detector arrays already build the analysis bank and the overall filter bank is completed with the synthesis bank, for which stabilized inverse filters are proposed, to compensate for the low-pass characteristics and to approximate perfect reconstruction. The synthesis filter branch can be realized in a so-called `direct form,' or the `polyphase form,' where the latter is an expenditure-optimal solution, which gives advantages when implemented in a signal processor. This paper attempts to introduce well-established concepts of the theory of multirate filter banks into the analysis of scanning imagers, which is applicable in a much broader sense than for the problems addressed here. To the author's knowledge this is also a novelty.

General object-oriented software development

NASA Technical Reports Server (NTRS)

Seidewitz, Edwin V.; Stark, Mike

1986-01-01

Object-oriented design techniques are gaining increasing popularity for use with the Ada programming language. A general approach to object-oriented design which synthesizes the principles of previous object-oriented methods into the overall software life-cycle, providing transitions from specification to design and from design to code. It therefore provides the basis for a general object-oriented development methodology.

Austrian National Space Law

NASA Astrophysics Data System (ADS)

Steinkogler, Cordula

2017-08-01

The Austrian Outer Space Act, which entered into force in December 2011; and the Austrian Outer Space Regulation, which has been in force since February 2015, form the legal framework for Austrian national space activities. The elaboration of national space legislation became necessary to ensure compliance with Austria's obligations as State Party to the five United Nations Space Treaties when the first two Austrian satellites were launched in 2012 and Austria became a launching state on its own. The legislation comprehensively regulates legal aspects related to space activities, such as authorization, supervision, and termination of space activities; registration and transfer of space objects; recourse of the government against the operator; as well as implementation of the law and sanctions for its infringement. One of the main purposes of the law is to ensure the authorization of national space activities. The Outer Space Act sets forth the main conditions for authorization, which inter alia refer to the expertise of the operator; requirements for orbital positions and frequency assignments; space debris mitigation, insurance requirements, and the safeguard of public order; public health; national security as well as Austrian foreign policy interests; and international law obligations. The Austrian Outer Space Regulation complements these provisions by specifying the documents the operator must submit as evidence of the fulfillment of the authorization conditions, which include the results of safety tests, emergency plans, and information on the collection and use of Earth observation data. Particular importance is attached to the mitigation of space debris. Operators are required to take measures in accordance with international space debris mitigation guidelines for the avoidance of operational debris, the prevention of on-orbit break-ups and collisions, and the removal of space objects from Earth orbit after the end of the mission. Another specificity of the Austrian space legislation is the possibility of an exemption from the insurance requirement or a reduction of the insurance sum, if the space activity is in the public interest. This allows support to space activities that serve science, research, and education. Moreover, the law also provides for the establishment of a national registry for objects launched into outer space by the competent Austrian Ministry. The first two Austrian satellites have been entered into this registry after their launch in 2012. The third Austrian satellite, launched in June 2017, will be the first satellite authorized under the Austrian space legislation.

Methods and apparatuses for reagent delivery, reactive barrier formation, and pest control

DOEpatents

Gilmore, Tyler [Pasco, WA; Kaplan, Daniel I [Aiken, SC; Last, George [Richland, WA

2002-07-09

A reagent delivery method includes positioning reagent delivery tubes in contact with soil. The tubes can include a wall that is permeable to a soil-modifying reagent. The method further includes supplying the reagent in the tubes, diffusing the reagent through the permeable wall and into the soil, and chemically modifying a selected component of the soil using the reagent. The tubes can be in subsurface contact with soil, including groundwater, and can be placed with directional drilling equipment independent of groundwater well casings. The soil-modifying reagent includes a variety of gases, liquids, colloids, and adsorbents that may be reactive or non-reactive with soil components. The method may be used inter alia to form reactive barriers, control pests, and enhance soil nutrients for microbes and plants.

The nearest relative in mental health law.

PubMed

Andoh, Benjamin; Gogo, Emmanuel

2004-04-01

This article considers the concept of the 'nearest relative' in mental health law in England and Wales and argues, inter alia, for its retention in a way that avoids violation of the European Convention on Human Rights and the Human Rights Act 1998. It looks, first, at the meaning of nearest relative and then focuses on his/her role today, including its link with advance directives for mental health care, and on the tension between nearest relatives and approved social workers and the law. The problem exposed by JT v. United Kingdom in relation to the Human Rights Act 1998 and its implications for the future are considered. The impact of the Mental Health Bill (2002) on the nearest relative is discussed and recommendations to improve the present law are then suggested.

The most interesting roAp target for MONS: HR1217 ?

NASA Astrophysics Data System (ADS)

Knudsen, M. R.

2000-04-01

The roAp star HR1217 is presented as a good and possibly the best roAp target for MONS and the progress of the 1998 3-site STACC Campaign is briefly summarized incl. the first detection of EW oscillation in Hα and Hβ in this star, alongside evidence of EW varying with the phase of rotation. HR1217 has 6 known oscillation frequencies of which the four strongest appear to be rotationally split with photometric amplitudes ~< 1 mmag. The problem with groundbased observations is the 3-day-alias beating with neighbouring peaks which limits our chances for a solid mode id. With 30 days (2.4ṡ Prot) on MONS CAM we should have the needed observational data for doing asteroseismology on a magnetic star at last!

Cholera studies*

PubMed Central

Pollitzer, R.

1957-01-01

In discussing prevention, the author deals first with the provision of permanently safe water, supplied from waterworks or wells, and with other improvements in environmental sanitation. Control of food and drinks, public health propaganda and education, and vaccination are also considered under this heading. The greater part of this study is devoted to suppressive measures, affecting the individual, the environment, and persons in the mass. Discussion of the isolation, detection and management of cholera patients, the management of contacts, and the management and treatment of carriers is followed by sections on, inter alia, disinfection, temporary improvements in water supplies, fly control, and personal prophylaxis. In dealing with mass prophylaxis, the author pays particular attention to vaccination. In the concluding sections he goes into the control of pilgrimages and local and international quarantine measures. PMID:13479774

Magnus Hirschfeld, his biographies and the possibilities and boundaries of "biography" as "doing history.".

PubMed

Brennan, Toni; Hegarty, Peter

2009-12-01

This article considers the two major biographies of sexologist Magnus Hirschfeld, MD (1868-1935), an early campaigner for "gay rights" avant la lettre. Like him, his first biographer Charlotte Wolff (1897-1986) was a Jewish doctor who lived and worked in Weimar Republic Berlin and fled Germany when the Nazi regime came to power. When researching Hirschfeld's biography (published in English in 1986) Wolff met a librarian and gay activist, Manfred Herzer, who would eventually be a cofounder of the Gay Museum in Berlin and publish (in German, in 1992) the other major Hirschfeld biography currently available. Using, inter alia, the correspondence between Wolff and Herzer, the article aims to explore and interrogate the boundaries and possibilities of "biography" as a form of "doing history."

Adiabatic invariant analysis of dark and dark-bright soliton stripes in two-dimensional Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Kevrekidis, P. G.; Wang, Wenlong; Carretero-González, R.; Frantzeskakis, D. J.

2018-06-01

In the present work, we develop an adiabatic invariant approach for the evolution of quasi-one-dimensional (stripe) solitons embedded in a two-dimensional Bose-Einstein condensate. The results of the theory are obtained both for the one-component case of dark soliton stripes, as well as for the considerably more involved case of the two-component dark-bright (alias "filled dark") soliton stripes. In both cases, analytical predictions regarding the stability and dynamics of these structures are obtained. One of our main findings is the determination of the instability modes of the waves as a function of the parameters of the system (such as the trap strength and the chemical potential). Our analytical predictions are favorably compared with results of direct numerical simulations.

[Empathic leadership: shaping positive change].

PubMed

Wetterauer, U; Ruhl, S

2011-12-01

This paper explains the concept of empathic leadership in the setting of fundamental organisational changes. It deals with the question of how you can establish a culture of leadership, which motivates employees positively and enthuses them for the upcoming changes. It discusses the basics of empathic leadership and considers the question of how handling of emotions influences change processes and how different management styles can be used supportively during changes. With the help of a practical example the different phases of change are presented from a management point of view. Thereby the theory of different levels of employee motivation is explained inter alia. The article shows that empathic leadership also has a lasting economic effect. This can be seen particularly in the power of motivation for change, in addition to recruitment and long-term employee retention.

Methodology for object-oriented real-time systems analysis and design: Software engineering

NASA Technical Reports Server (NTRS)

Schoeffler, James D.

1991-01-01

Successful application of software engineering methodologies requires an integrated analysis and design life-cycle in which the various phases flow smoothly 'seamlessly' from analysis through design to implementation. Furthermore, different analysis methodologies often lead to different structuring of the system so that the transition from analysis to design may be awkward depending on the design methodology to be used. This is especially important when object-oriented programming is to be used for implementation when the original specification and perhaps high-level design is non-object oriented. Two approaches to real-time systems analysis which can lead to an object-oriented design are contrasted: (1) modeling the system using structured analysis with real-time extensions which emphasizes data and control flows followed by the abstraction of objects where the operations or methods of the objects correspond to processes in the data flow diagrams and then design in terms of these objects; and (2) modeling the system from the beginning as a set of naturally occurring concurrent entities (objects) each having its own time-behavior defined by a set of states and state-transition rules and seamlessly transforming the analysis models into high-level design models. A new concept of a 'real-time systems-analysis object' is introduced and becomes the basic building block of a series of seamlessly-connected models which progress from the object-oriented real-time systems analysis and design system analysis logical models through the physical architectural models and the high-level design stages. The methodology is appropriate to the overall specification including hardware and software modules. In software modules, the systems analysis objects are transformed into software objects.

Optical noninvasive calculation of hemoglobin components concentrations and fractional oxygen saturation using a ring-scattering pulse oximeter

NASA Astrophysics Data System (ADS)

Abdallah, Omar; Stork, Wilhelm; Muller-Glaser, Klaus

2004-06-01

The deficiencies of the currently used pulse oximeter are discussed in diverse literature. A hazardous pitfalls of this method is that the pulse oximeter will not detect carboxyhemoglobin (COHb) and methemoglobin (metHb) concentrations. This leads to incorrect measurement of oxygen saturation by carbon monoxide poisoning and methemoglobinemia. Also the total hemoglobin concentration will not be considered and can only be measured in-vitro up to now. A second pitfall of the standard pulse oximetry is that it will not be able to show a result by low perfusion of tissues. This case is available inter alia when the patient is under shock or has a low blood pressure. The new non-invasive system we designed measures the actual (fractional) oxygen saturation and hemoglobin concentration. It will enable us also to measure COHb and metHb. The measurement can be applied at better perfused body central parts. Four or more light emitting diodes (LEDs) or laser diodes (LDs) and five photodiodes (PDs) are used. The reflected light signal detected by photodiodes is processed using a modified Lambert-Beer law (I=I0×e-α.d ). According to this law, when a non scattering probe is irradiated with light having the incident intensity I0, the intensity of transmitted light I decays exponentially with the absorption coefficient a of that probe and its thickness d. Modifications of this law have been performed following the theoretical developed models in literature, Monte Carlo simulation and experimental measurement.

A virtual reality atlas of craniofacial anatomy.

PubMed

Smith, Darren M; Oliker, Aaron; Carter, Christina R; Kirov, Miro; McCarthy, Joseph G; Cutting, Court B

2007-11-01

Head and neck anatomy is complex and represents an educational challenge to the student. Conventional two-dimensional illustrations inherently fall short in conveying intricate anatomical relationships that exist in three dimensions. A gratis three-dimensional virtual reality atlas of craniofacial anatomy is presented in an effort to address the paucity of readily accessible and customizable three-dimensional educational material available to the student of head and neck anatomy. Three-dimensional model construction was performed in Alias Maya 4.5 and 6.0. A basic three-dimensional skull model was altered to include surgical landmarks and proportions. Some of the soft tissues were adapted from previous work, whereas others were constructed de novo. Texturing was completed with Adobe Photoshop 7.0 and Maya. The Internet application was designed in Viewpoint Enliven 1.0. A three-dimensional computer model of craniofacial anatomy (bone and soft tissue) was completed. The model is compatible with many software packages and can be accessed by means of the Internet or downloaded to a personal computer. As the three-dimensional meshes are publicly available, they can be extensively manipulated by the user, even at the polygonal level. Three-dimensional computer graphics has yet to be fully exploited for head and neck anatomy education. In this context, the authors present a publicly available computer model of craniofacial anatomy. This model may also find applications beyond clinical medicine. The model can be accessed gratis at the Plastic and Reconstructive Surgery Web site or obtained as a three-dimensional mesh, also gratis, by contacting the authors.

`Cranach Inc.' A case study determining the nature and extent of Lucas Cranach the Elder's involvement in his industrious workshop using image processing

NASA Astrophysics Data System (ADS)

Lubashevsky, Ruth

2015-06-01

Lucas Cranach the Elder (LCE) (1472-1553) maintained an organized and highly efficient workshop, served as councilor in Wittenberg from 1519-1544, established a publishing house in 1520, held a pharmacy from 1520, and served as mayor of Wittenberg from 1537 to 1543. He was known as the 'swiftest of painters,' resulting in 1,000 surviving panel paintings, canvas paintings, drawings, and etchings in a career that spanned 53 years (1500-1553). Facing this astoundingly enormous oeuvre, the question that this paper seeks to answer is unavoidable: what was LCE's involvement in this oeuvre, which most is still attributed to him, in light of his many other time-consuming engagements? To answer this question, this paper becomes a study of stylistic comparisons of LCE's oeuvre, in order to assess, analyze and identify his style to determine whether all of the works attributed to him were indeed his own handiwork. Classifying LCE's style, together with the fact that he ran his workshop in factory-like conditions, supplying his apprentices with pigments, designs they could trace, copies, modelling versions, and patterns, making him an artist turned businessman, LCE becomes an artist who turned art into an industrial operation, earning the title 'Cranach Inc.' The conclusion of this paper will be based inter-alia on comparisons between Infra-red images and the visible paintings, in order to undermine the established attributions made to LCE.

Analysis of the mechanical behavior of single wall carbon nanotubes by a modified molecular structural mechanics model incorporating an advanced chemical force field

NASA Astrophysics Data System (ADS)

Eberhardt, Oliver; Wallmersperger, Thomas

2018-03-01

The outstanding properties of carbon nanotubes (CNTs) keep attracting the attention of researchers from different fields. CNTs are promising candidates for applications e.g. in lightweight construction but also in electronics, medicine and many more. The basis for the realization of the manifold applications is a detailed knowledge of the material properties of the carbon nanotubes. In particular for applications in lightweight constructions or in composites, the knowledge of the mechanical behavior of the CNTs is of vital interest. Hence, a lot of effort is put into the experimental and theoretical determination of the mechanical material properties of CNTs. Due to their small size, special techniques have to be applied. In this research, a modified molecular structural mechanics model for the numerical determination of the mechanical behavior of carbon nanotubes is presented. It uses an advanced approach for the geometrical representation of the CNT structure while the covalent bonds in the CNTs are represented by beam elements. Furthermore, the model is specifically designed to overcome major drawbacks in existing molecular structural mechanics models. This includes energetic consistency with the underlying chemical force field. The model is developed further to enable the application of a more advanced chemical force field representation. The developed model is able to predict, inter alia, the lateral and radial stiffness properties of the CNTs. The results for the lateral stiffness are given and discussed in order to emphasize the progress made with the presented approach.

ALIAS (Albumin in Acute Ischemic Stroke) Trials: Analysis of the Combined Data From Parts 1 and 2.

PubMed

Martin, Renee' H; Yeatts, Sharon D; Hill, Michael D; Moy, Claudia S; Ginsberg, Myron D; Palesch, Yuko Y

2016-09-01

The ALIAS (Albumin in Acute Ischemic Stroke) part 1 and 2 trials evaluated whether 25% human serum albumin improves clinical outcomes after acute ischemic stroke above and beyond standard of care using similar protocols. The part 1 trial ended prematurely because of safety concerns, and the part 2 trial terminated early because of futility of finding a statistically significant effect of albumin over saline (control) administration. We combine the subject-level data of the part 1 and 2 trials to reevaluate the efficacy and safety outcomes with the larger sample size. The combined data analyses closely follow those conducted in the part 2 trial. The primary outcome is the composite of the modified Rankin Scale and the National Institutes of Health Stroke Scale defined as a composite of modified Rankin Scale score 0 to 1 and National Institutes of Health Stroke Scale score 0 to 1 at 90 days from randomization. The unadjusted analyses use a simple Chi-square test, and those adjusting for baseline covariates use a generalized linear model with log link (to obtain relative risks). The participant characteristics at baseline were generally similar between the treatment groups and between the trials; however, thrombolysis use was greater in part 2 (84% versus 75%), and the upper age limit imposed in part 2 resulted in a younger sample (mean age in part 1 was 69 versus 64 in part 2). In the combined sample, the proportions of good outcome in the 2 treatment groups were identical (41%). Similar results were observed in all secondary efficacy outcomes. Pulmonary edema was a consistent safety concern, with a 6-fold increase in the albumin arm (13%) compared with saline (2%; relative risk =7.76, 95% confidence interval 3.87-15.57). Treatment with intravenous albumin 25% at 2 g/kg was not associated with improved outcome at 90 days and was associated with increased rates of intracerebral hemorrhage and pulmonary edema. URL: https://www.clinicaltrials.gov. Unique identifier: NCT00235495. © 2016 American Heart Association, Inc.

Reuseable Objects Software Environment (ROSE): Introduction to Air Force Software Reuse Workshop

NASA Technical Reports Server (NTRS)

Cottrell, William L.

1994-01-01

The Reusable Objects Software Environment (ROSE) is a common, consistent, consolidated implementation of software functionality using modern object oriented software engineering including designed-in reuse and adaptable requirements. ROSE is designed to minimize abstraction and reduce complexity. A planning model for the reverse engineering of selected objects through object oriented analysis is depicted. Dynamic and functional modeling are used to develop a system design, the object design, the language, and a database management system. The return on investment for a ROSE pilot program and timelines are charted.

Towards a general object-oriented software development methodology

NASA Technical Reports Server (NTRS)

Seidewitz, ED; Stark, Mike

1986-01-01

An object is an abstract software model of a problem domain entity. Objects are packages of both data and operations of that data (Goldberg 83, Booch 83). The Ada (tm) package construct is representative of this general notion of an object. Object-oriented design is the technique of using objects as the basic unit of modularity in systems design. The Software Engineering Laboratory at the Goddard Space Flight Center is currently involved in a pilot program to develop a flight dynamics simulator in Ada (approximately 40,000 statements) using object-oriented methods. Several authors have applied object-oriented concepts to Ada (e.g., Booch 83, Cherry 85). It was found that these methodologies are limited. As a result a more general approach was synthesized with allows a designer to apply powerful object-oriented principles to a wide range of applications and at all stages of design. An overview is provided of this approach. Further, how object-oriented design fits into the overall software life-cycle is considered.

Towards a general object-oriented software development methodology

NASA Technical Reports Server (NTRS)

Seidewitz, ED; Stark, Mike

1986-01-01

Object diagrams were used to design a 5000 statement team training exercise and to design the entire dynamics simulator. The object diagrams are also being used to design another 50,000 statement Ada system and a personal computer based system that will be written in Modula II. The design methodology evolves out of these experiences as well as the limitations of other methods that were studied. Object diagrams, abstraction analysis, and associated principles provide a unified framework which encompasses concepts from Yourdin, Booch, and Cherry. This general object-oriented approach handles high level system design, possibly with concurrency, through object-oriented decomposition down to a completely functional level. How object-oriented concepts can be used in other phases of the software life-cycle, such as specification and testing is being studied concurrently.

Multimode optomechanical system in the quantum regime.

PubMed

Nielsen, William Hvidtfelt Padkær; Tsaturyan, Yeghishe; Møller, Christoffer Bo; Polzik, Eugene S; Schliesser, Albert

2017-01-03

We realize a simple and robust optomechanical system with a multitude of long-lived (Q > 10 7 ) mechanical modes in a phononic-bandgap shielded membrane resonator. An optical mode of a compact Fabry-Perot resonator detects these modes' motion with a measurement rate (96 kHz) that exceeds the mechanical decoherence rates already at moderate cryogenic temperatures (10 K). Reaching this quantum regime entails, inter alia, quantum measurement backaction exceeding thermal forces and thus strong optomechanical quantum correlations. In particular, we observe ponderomotive squeezing of the output light mediated by a multitude of mechanical resonator modes, with quantum noise suppression up to -2.4 dB (-3.6 dB if corrected for detection losses) and bandwidths ≲90 kHz. The multimode nature of the membrane and Fabry-Perot resonators will allow multimode entanglement involving electromagnetic, mechanical, and spin degrees of freedom.

ALIAS (Acquisition and Logistics Information and Analysis System) Maintenance and Expansion Guide. Volume 2.

DTIC Science & Technology

1984-10-31

PURPOSE UTILITIES! C. C.CT2 .t tt.t t.t, 4.t44.• 4 *• tt 4t t • t t tt* t tttt t SCONTROL check-2 SUBRO.UTINE ccat2 .sl,lenl,s2,len2,sr, lenr ,nlenr) C.4...same address as sI or s2 C-C t lenr length of sr Cin 4lenr naxiPsum length allowable for sr C.tETH0Q. C D.TS. refers to a Delimited Text String, in which...DECLARATIONS **. !9TESER !enIlen2,1!n3,!en4, lenr ,m1enr CKARACTER.25S sl, sZ, s3, s4., sr C.* ABSTRACT *.. Cl.PURPOSE -erfor..s sr sl ’’ s2 ’: s3 C.OUOIT HIS.TORY

Anomalous hydrodynamics and normal fluids in rapidly rotating Bose-Einstein condensates.

PubMed

Bourne, A; Wilkin, N K; Gunn, J M F

2006-06-23

In rapidly rotating condensed Bose systems we show that there is a regime of anomalous hydrodynamics which coincides with the mean field quantum Hall regime. A consequence is the absence of a normal fluid in any conventional sense. However, even the superfluid hydrodynamics is not described by conventional Bernoulli and continuity equations. We show that there are constraints which connect spatial variations of density and phase and that the vortex positions are not the simplest description of the dynamics. We demonstrate, inter alia, a simple relation between vortices and surface waves. We show that the surface waves can emulate a "normal fluid," allowing dissipation by energy and angular momentum absorbtion from vortex motion in the trap. The time scale is sensitive to the initial configuration, which can lead to long-lived vortex patches--perhaps related to those observed at JILA.

Differential levels of metabolic activity in isolated versus confluent/partially confluent HeLa cells are analyzed by autofluorescent NAD(P)H using multi-photon FLIM microscopy

NASA Astrophysics Data System (ADS)

Chandler, Andrea; Chandler, Aaron; Wallrabe, Horst; Periasamy, Ammasi

2017-02-01

NAD(P)H is a known biomarker for cellular metabolism; a higher ratio of enzyme-bound NAD(P)H to free/unbound NAD(P)H indicates an increase in metabolic activity. Free NADH has a shorter fluorescence lifetime (τ1), the bound version (τ2) a longer lifetime. FLIM's unique capability to establish inter alia the relative fractions of τ1 (a1%) and τ2 (a2%) in each pixel, determines the level of metabolic activity. The relative abundances of bound NAD(P)H were analyzed for single cells, confluent and partially confluent cells within 3 Fields-of-View (FoVs). A gradient of increasing a 2% levels of bound NAD(P)H from single, partially confluent to confluent cells was observed.

Improvement of carbon nanotubes films conductivity for use in biomedical application

NASA Astrophysics Data System (ADS)

Dybowska-Sarapuk, Łucja; Janczak, Daniel; Krzemiński, Jakub; Lepak, Sandra; Łekawa-Raus, Agnieszka; MłoŻniak, Anna; Jakubowska, Małgorzata

2017-08-01

Carbon nanotube (CNT) yarns and sheets due to their biocompatibility, very good mechanical strength and flexibility can find wide range of applications in nanomedicine, inter alia as mechanical actuators for artificial muscles or electrodes used for deep brain stimulation. However, because of CNT film behavior in liquid environment, before their using in biological applications, they should be coated with a special protective layer. The purpose of created coatings is not only to protect the films, but also to increase their conductivity. The aim of the research was to test various methods of achieving such coatings on CNT films and to evaluate quality and flexibility of coated CNT films. The coatings were made using various suspensions containing polymer materials such methyl polymethacrylate and conductive silver flakes. The methods tested in this study were: dipping, painting and flooding of the CNT yarns.

Oil and Gas Field Code Master List 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This is the ninth annual edition of the Energy Information Administration's (EIA) Oil and Gas Field Code Master List. It reflects data collected through October 1990 and provides standardized field name spellings and codes for all identified oil and/or gas fields in the United States. There are 54,963 field records in this year's Oil and Gas Field Code Master List (FCML). This amounts to 467 more than in last year's report. As it is maintained by EIA, the Master List includes: Field records for each state and county in which a field resides; field records for each offshore area blockmore » in the Gulf of Mexico in which a field resides;field records for each alias field name; fields crossing state boundaries that may be assigned different names by the respective state naming authorities.« less

Strategic development in exact calculation: group and individual differences in four achievement subtypes.

PubMed

Wylie, Judith; Jordan, Julie-Ann; Mulhern, Gerry

2012-09-01

This longitudinal study sought to identify developmental changes in strategy use between 5 and 7 years of age when solving exact calculation problems. Four mathematics and reading achievement subtypes were examined at four time points. Five strategies were considered: finger counting, verbal counting, delayed retrieval, automatic retrieval, and derived fact retrieval. Results provided unique insights into children's strategic development in exact calculation at this early stage. Group analysis revealed relationships between mathematical and/or reading difficulties and strategy choice, shift, and adaptiveness. Use of derived fact retrieval by 7 years of age distinguished children with mathematical difficulties from other achievement subtypes. Analysis of individual differences revealed marked heterogeneity within all subtypes, suggesting (inter alia) no marked qualitative distinction between our two mathematical difficulty subtypes. Copyright © 2012 Elsevier Inc. All rights reserved.

Multimode optomechanical system in the quantum regime

NASA Astrophysics Data System (ADS)

Hvidtfelt Padkær Nielsen, William; Tsaturyan, Yeghishe; Møller, Christoffer Bo; Polzik, Eugene S.; Schliesser, Albert

2017-01-01

We realize a simple and robust optomechanical system with a multitude of long-lived (Q > 107) mechanical modes in a phononic-bandgap shielded membrane resonator. An optical mode of a compact Fabry-Perot resonator detects these modes’ motion with a measurement rate (96 kHz) that exceeds the mechanical decoherence rates already at moderate cryogenic temperatures (10 K). Reaching this quantum regime entails, inter alia, quantum measurement backaction exceeding thermal forces and thus strong optomechanical quantum correlations. In particular, we observe ponderomotive squeezing of the output light mediated by a multitude of mechanical resonator modes, with quantum noise suppression up to -2.4 dB (-3.6 dB if corrected for detection losses) and bandwidths ≲90 kHz. The multimode nature of the membrane and Fabry-Perot resonators will allow multimode entanglement involving electromagnetic, mechanical, and spin degrees of freedom.

Onsite aerosol measurements for various engineered nanomaterials at industrial manufacturing plants

NASA Astrophysics Data System (ADS)

Ogura, I.; Sakurai, H.; Gamo, M.

2011-07-01

Evaluation of the health impact of and control over exposure to airborne engineered nanomaterials (ENMs) requires information, inter alia, the magnitude of environmental release during various industrial processes, as well as the size distribution and morphology of the airborne ENM particles. In this study, we performed onsite aerosol measurements for various ENMs at industrial manufacturing plants. The industrial processes investigated were the collection of SiC from synthesis reactors, synthesis and bagging of LiFePO4, and bagging of ZnO. Real-time aerosol monitoring using condensation particle counters, optical particle counters, and an electrical low-pressure impactor revealed frequent increases in the number concentrations of submicron- and micron-sized aerosol particles, but few increases in the number concentrations of nanoparticles. In the SEM observations, a large number of submicron- and micron-sized agglomerated ENM particles were observed.

Real-time combustion controller

DOEpatents

Lindner, Jeffrey S.; Shepard, W. Steve; Etheridge, John A.; Jang, Ping-Rey; Gresham, Lawrence L.

1997-01-01

A method and system of regulating the air to fuel ratio supplied to a burner to maximize the combustion efficiency. Optical means are provided in close proximity to the burner for directing a beam of radiation from hot gases produced by the burner to a plurality of detectors. Detectors are provided for sensing the concentration of, inter alia, CO, CO.sub.2, and H.sub.2 O. The differences between the ratios of CO to CO.sub.2 and H.sub.2 O to CO are compared with a known control curve based on those ratios for air to fuel ratios ranging from 0.85 to 1.30. The fuel flow is adjusted until the difference between the ratios of CO to CO.sub.2 and H.sub.2 O to CO fall on a desired set point on the control curve.

Long memory and volatility clustering: Is the empirical evidence consistent across stock markets?

NASA Astrophysics Data System (ADS)

Bentes, Sónia R.; Menezes, Rui; Mendes, Diana A.

2008-06-01

Long memory and volatility clustering are two stylized facts frequently related to financial markets. Traditionally, these phenomena have been studied based on conditionally heteroscedastic models like ARCH, GARCH, IGARCH and FIGARCH, inter alia. One advantage of these models is their ability to capture nonlinear dynamics. Another interesting manner to study the volatility phenomenon is by using measures based on the concept of entropy. In this paper we investigate the long memory and volatility clustering for the SP 500, NASDAQ 100 and Stoxx 50 indexes in order to compare the US and European Markets. Additionally, we compare the results from conditionally heteroscedastic models with those from the entropy measures. In the latter, we examine Shannon entropy, Renyi entropy and Tsallis entropy. The results corroborate the previous evidence of nonlinear dynamics in the time series considered.

Laser beam apparatus and method for analyzing solar cells

DOEpatents

Staebler, David L.

1980-01-01

A laser beam apparatus and method for analyzing, inter alia, the current versus voltage curve at the point of illumination on a solar cell and the open circuit voltage of a solar cell. The apparatus incorporates a lock-in amplifier, and a laser beam light chopper which permits the measurement of the AC current of the solar cell at an applied DC voltage at the position on the solar cell where the cell is illuminated and a feedback scheme which permits the direct scanning measurements of the open circuit voltage. The accuracy of the measurement is a function of the intensity and wavelength of the laser light with respect to the intensity and wavelength distribution of sunlight and the percentage the dark current is at the open circuit voltage to the short circuit current of the solar cell.

Real-time combustion controller

DOEpatents

Lindner, J.S.; Shepard, W.S.; Etheridge, J.A.; Jang, P.R.; Gresham, L.L.

1997-02-04

A method and system are disclosed for regulating the air to fuel ratio supplied to a burner to maximize the combustion efficiency. Optical means are provided in close proximity to the burner for directing a beam of radiation from hot gases produced by the burner to a plurality of detectors. Detectors are provided for sensing the concentration of, inter alia, CO, CO{sub 2}, and H{sub 2}O. The differences between the ratios of CO to CO{sub 2} and H{sub 2}O to CO are compared with a known control curve based on those ratios for air to fuel ratios ranging from 0.85 to 1.30. The fuel flow is adjusted until the difference between the ratios of CO to CO{sub 2} and H{sub 2}O to CO fall on a desired set point on the control curve. 20 figs.

40 CFR 97.214 - Objections concerning CAIR designated representative.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Objections concerning CAIR designated... Designated Representative for CAIR SO2 Sources § 97.214 Objections concerning CAIR designated representative... authority or the Administrator concerning the authorization, or any representation, action, inaction, or...

40 CFR 97.314 - Objections concerning CAIR designated representative.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Objections concerning CAIR designated... Designated Representative for CAIR NOX Ozone Season Sources § 97.314 Objections concerning CAIR designated... the permitting authority or the Administrator concerning the authorization, or any representation...

40 CFR 60.4114 - Objections concerning Hg designated representative.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Objections concerning Hg designated... § 60.4114 Objections concerning Hg designated representative. (a) Once a complete certificate of... concerning the authorization, or any representation, action, inaction, or submission, of the Hg designated...

40 CFR 97.114 - Objections concerning CAIR designated representative.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Objections concerning CAIR designated... Designated Representative for CAIR NOX Sources § 97.114 Objections concerning CAIR designated representative... authority or the Administrator concerning the authorization, or any representation, action, inaction, or...

Decomposition-Based Decision Making for Aerospace Vehicle Design

NASA Technical Reports Server (NTRS)

Borer, Nicholas K.; Mavris, DImitri N.

2005-01-01

Most practical engineering systems design problems have multiple and conflicting objectives. Furthermore, the satisfactory attainment level for each objective ( requirement ) is likely uncertain early in the design process. Systems with long design cycle times will exhibit more of this uncertainty throughout the design process. This is further complicated if the system is expected to perform for a relatively long period of time, as now it will need to grow as new requirements are identified and new technologies are introduced. These points identify a need for a systems design technique that enables decision making amongst multiple objectives in the presence of uncertainty. Traditional design techniques deal with a single objective or a small number of objectives that are often aggregates of the overarching goals sought through the generation of a new system. Other requirements, although uncertain, are viewed as static constraints to this single or multiple objective optimization problem. With either of these formulations, enabling tradeoffs between the requirements, objectives, or combinations thereof is a slow, serial process that becomes increasingly complex as more criteria are added. This research proposal outlines a technique that attempts to address these and other idiosyncrasies associated with modern aerospace systems design. The proposed formulation first recasts systems design into a multiple criteria decision making problem. The now multiple objectives are decomposed to discover the critical characteristics of the objective space. Tradeoffs between the objectives are considered amongst these critical characteristics by comparison to a probabilistic ideal tradeoff solution. The proposed formulation represents a radical departure from traditional methods. A pitfall of this technique is in the validation of the solution: in a multi-objective sense, how can a decision maker justify a choice between non-dominated alternatives? A series of examples help the reader to observe how this technique can be applied to aerospace systems design and compare the results of this so-called Decomposition-Based Decision Making to more traditional design approaches.

Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) among adult eating disorder patients.

PubMed

Svedlund, Nils Erik; Norring, Claes; Ginsberg, Ylva; von Hausswolff-Juhlin, Yvonne

2017-01-17

Very little is known about the prevalence of ADHD symptoms in Bulimia Nervosa and Binge Eating Disorder and even less in other eating disorders. This knowledge gap is of clinical importance since stimulant treatment is proven effective in Binge Eating Disorder and discussed as a treatment possibility for Bulimia Nervosa. The objective of this study was to explore the prevalence and types of self-reported ADHD symptoms in an unselected group of eating disorder patients assessed in a specialized eating disorder clinic. In total 1165 adults with an eating disorder were assessed with a battery of standardized instruments, for measuring inter alia ADHD screening, demographic variables, eating disorder symptoms and psychiatric comorbidity. Chi-square tests were used for categorical variables and Kruskal-Wallis tests for continuous variables. Almost one third (31.3 %) of the patients scored above the screening cut off indicating a possible ADHD. The highest prevalence rates (35-37 %) were found in Bulimia Nervosa and Anorexia Nervosa bingeing/purging subtype, while Eating Disorder Not Otherwise Specified type 1-4 and Binge Eating Disorder patients reported slightly below average (26-31 %), and Anorexia Nervosa restricting subtype patients even lower (18 %). Presence of binge eating, purging, loss of control over eating and non-anorectic BMI were related to results indicating a possible ADHD. Psychiatric comorbidity correlated to ADHD symptoms without explaining the differences between eating disorder diagnoses. There is a high frequency of ADHD symptoms in patients with binge eating/purging eating disorders that motivates further studies, particularly concerning the effects of ADHD medication. The finding that the frequency of ADHD symptoms in anorexia nervosa with binge eating/purging is as high as in bulimia nervosa highlights the need also for this group.

Food Security, Institutional Framework and Technology: Examining the Nexus in Nigeria Using ARDL Approach

PubMed Central

Osabohien, Romanus; Osabuohien, Evans; Urhie, Ese

2018-01-01

Background: Growth in agricultural science and technology is deemed essential for in-creasing agricultural output; reduce the vulnerability of rural poverty and in turn, food security. Food security and growth in agricultural output depends on technological usages, which enhances the pro-ductive capacity of the agricultural sector. The indicators of food security utilised in this study in-clude: dietary energy supply, average value of food production, prevalence of food inadequacy, among others. Objective: In this paper, we examined the level of technology and how investment in the agriculture and technology can improve technical know-how in Nigeria with a view to achieving food security. Method: We carried out the analysis on how investment in technology and institutional framework can improve the level of food availability (a key component of food security) in Nigeria using econ-ometric technique based on Autoregressive Distribution Lag (ARDL) framework. Results: The results showed, inter alia, that in Nigeria, there is a high level of food insecurity as a result of low attention on food production occasioned by the pervasive influence of oil that become the major export product. Conclusion: It was noted that the availability of arable land was one of the major factors to increase food production to solve the challenge of food insecurity. Thus, the efforts of reducing the rate of food insecurity are essential in this regards. This can also be achieved, among others, by active interactions between government and farmers, to make contribution to important planning issues that relate to food production in the country and above all, social protection policies should be geared or channelled to agricultural sector to protect farmers who are vulnerable to shocks and avert risks associated with agriculture. PMID:29853816

[Standard of integration management at company level and its auditing].

PubMed

Flach, T; Hetzel, C; Mozdzanowski, M; Schian, H-M

2006-10-01

Responsibility at company level for the employment of workers with health-related problems or disabilities has increased, inter alia because of integration management at company level according to section 84 (2) of the German Social Code Book IX. Although several recommendations exist, no standard is available for auditing and certification. Such a standard could be a basis for granting premiums according to section 84 (3) of Book IX of the German Social Code. AUDIT AND CERTIFICATION: One product of the international "disability management" movement is the "Consensus Based Disability Management Audit" (CBDMA). The Audit is a systematic and independent measurement of the effectiveness of integration management at company level. CBDMA goals are to give evidence of the quality of the integration management implemented, to identify opportunities for improvement and recommend appropriate corrective and preventive action. In May 2006, the integration management of Ford-Werke GmbH Germany with about 23 900 employees was audited and certified as the first company in Europe. STANDARD OF INTEGRATION MANAGEMENT AT COMPANY LEVEL: In dialogue with corporate practitioners, the international standard of CBDMA has been adapted, completed and verified concerning its practicability. Process orientation is the key approach, and the structure is similar to DIN EN ISO 9001:2000. Its structure is as follows: (1) management-labour responsibility (goals and objectives, program planning, management-labour review), (2) management of resources (disability manager and DM team, employees' participation, cooperation with external partners, infrastructure), (3) communication (internal and external public relations), (4) case management (identifying cases, contact, situation analysis, planning actions, implementing actions and monitoring, process and outcome evaluation), (5) analysis and improvement (analysis and program evaluation), (6) documentation (manual, records).

Evaluation of global water quality - the potential of a data- and model-driven analysis

NASA Astrophysics Data System (ADS)

Bärlund, Ilona; Flörke, Martina; Alcamo, Joseph; Völker, Jeanette; Malsy, Marcus; Kaus, Andrew; Reder, Klara; Büttner, Olaf; Katterfeld, Christiane; Dietrich, Désirée; Borchardt, Dietrich

2016-04-01

The ongoing socio-economic development presents a new challenge for water quality worldwide, especially in developing and emerging countries. It is estimated that due to population growth and the extension of water supply networks, the amount of waste water will rise sharply. This can lead to an increased risk of surface water quality degradation, if the wastewater is not sufficiently treated. This development has impacts on ecosystems and human health, as well as food security. The United Nations Member States have adopted targets for sustainable development. They include, inter alia, sustainable protection of water quality and sustainable use of water resources. To achieve these goals, appropriate monitoring strategies and the development of indicators for water quality are required. Within the pre-study for a 'World Water Quality Assessment' (WWQA) led by United Nations Environment Programme (UNEP), a methodology for assessing water quality, taking into account the above-mentioned objectives has been developed. The novelty of this methodology is the linked model- and data-driven approach. The focus is on parameters reflecting the key water quality issues, such as increased waste water pollution, salinization or eutrophication. The results from the pre-study show, for example, that already about one seventh of all watercourses in Latin America, Africa and Asia show high organic pollution. This is of central importance for inland fisheries and associated food security. In addition, it could be demonstrated that global water quality databases have large gaps. These must be closed in the future in order to obtain an overall picture of global water quality and to target measures more efficiently. The aim of this presentation is to introduce the methodology developed within the WWQA pre-study and to show selected examples of application in Latin America, Africa and Asia.

Construction typification as the tool for optimizing the functioning of a robotized manufacturing system

NASA Astrophysics Data System (ADS)

Gwiazda, A.; Banas, W.; Sekala, A.; Foit, K.; Hryniewicz, P.; Kost, G.

2015-11-01

Process of workcell designing is limited by different constructional requirements. They are related to technological parameters of manufactured element, to specifications of purchased elements of a workcell and to technical characteristics of a workcell scene. This shows the complexity of the design-constructional process itself. The results of such approach are individually designed workcell suitable to the specific location and specific production cycle. Changing this parameters one must rebuild the whole configuration of a workcell. Taking into consideration this it is important to elaborate the base of typical elements of a robot kinematic chain that could be used as the tool for building Virtual modelling of kinematic chains of industrial robots requires several preparatory phase. Firstly, it is important to create a database element, which will be models of industrial robot arms. These models could be described as functional primitives that represent elements between components of the kinematic pairs and structural members of industrial robots. A database with following elements is created: the base kinematic pairs, the base robot structural elements, the base of the robot work scenes. The first of these databases includes kinematic pairs being the key component of the manipulator actuator modules. Accordingly, as mentioned previously, it includes the first stage rotary pair of fifth stage. This type of kinematic pairs was chosen due to the fact that it occurs most frequently in the structures of industrial robots. Second base consists of structural robot elements therefore it allows for the conversion of schematic structures of kinematic chains in the structural elements of the arm of industrial robots. It contains, inter alia, the structural elements such as base, stiff members - simple or angular units. They allow converting recorded schematic three-dimensional elements. Last database is a database of scenes. It includes elements of both simple and complex: simple models of technological equipment, conveyors models, models of the obstacles and like that. Using these elements it could be formed various production spaces (robotized workcells), in which it is possible to virtually track the operation of an industrial robot arm modelled in the system.

Learning Experience as Transaction: A Framework for Instructional Design

ERIC Educational Resources Information Center

Parrish, Patrick E.; Wilson, Brent G.; Dunlap, Joanna C.

2011-01-01

This article presents a framework for understanding learning experience as an object for instructional design--as an object for design as well as research and understanding. Compared to traditional behavioral objectives or discrete cognitive skills, the object of experience is more holistic, requiring simultaneous attention to cognition, behavior,…

A Study to Design, Develop, Implement, Evaluate, and Revise Specific, Measurable Performance Objectives to Serve as a Model to Individualize Instruction for Secondary Schools. Final Report.

ERIC Educational Resources Information Center

Wendt, Marilynn S.; Jacobson, Marjory E.

Specific objectives of this two-phase study included: (1) assessment of design of the behavioral objectives in all secondary level courses; (2) construction of criteria for evaluation of the design; (3) testing of objectives against the evaluative criteria and/or the specifications of the curriculum design; and (4) determination of the validity of…

Latest developments in peri-operative monitoring of the high-risk major surgery patient.

PubMed

Green, David; Paklet, Lise

2010-01-01

Peri-operative monitoring technology has made great strides in the last 20 years with the introduction of minimally invasive devices to measure inter alia stroke volume, cardiac output, depth of anaesthesia and cerebral and tissue oxygen monitoring. Despite these technological advances, peri-operative management of the high risk major surgery patient has remained virtually unchanged. The vast majority of patients undergo a pre-operative assessment which is neither designed to quantify functional capacity nor predict outcome. Anaesthetists then usually monitor these patients using the same technology (e.g. pulse oximetry (SpO2), invasive systemic BP and CVP, end tidal carbon dioxide (etCO2) and anaesthetic agent monitoring) that was available in the early 1980s. Conventional intra-operative management can result in occult low levels of blood flow and oxygen delivery that lead to complications that only occur days or weeks following surgery and give false re-assurance to the anaesthetist that he or she is doing a "good job". Post-operative management then often takes place in an environment with reduced levels of both monitoring equipment and staff expertise. It is perhaps not surprising that outcome still remains poor in high-risk patients.(1) In this review, we will briefly describe the role of peri-operative optimization, some of the available monitors and indicate how their combined use might be beneficial in managing the high-risk surgical patient. We believe that although there is now evidence to suggest that the use of individual new monitors (such as assessment of fluid status, depth of anaesthesia, tissue oxygenation and blood flow) can influence outcome, it will only be their combination that will radically improve the peri-operative management and outcome of high-risk surgical patients. It is a matter of some urgency that large scale, prospective and collaborative studies be designed, funded and executed to prove or disprove this hypothesis. Copyright 2009 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

A multiphoton objective design with incorporated beam splitter for enhanced fluorescence collection

PubMed Central

McMullen, Jesse D.; Zipfel, Warren R.

2010-01-01

We present a de novo design of an objective for use in multi-photon (MPM) and second harmonic generation (SHG) microscopy. This objective was designed to have a large field of view (FOV), while maintaining a moderate numerical aperture (NA) and relative straight forward construction. A dichroic beam splitter was incorporated within the objective itself allowing for an increase in the front aperture of the objective and corresponding enhancement of the solid angle of collected emission by an order of magnitude over existing designs. PMID:20389554

A multiphoton objective design with incorporated beam splitter for enhanced fluorescence collection.

PubMed

McMullen, Jesse D; Zipfel, Warren R

2010-03-15

We present a de novo design of an objective for use in multi-photon (MPM) and second harmonic generation (SHG) microscopy. This objective was designed to have a large field of view (FOV), while maintaining a moderate numerical aperture (NA) and relative straight forward construction. A dichroic beam splitter was incorporated within the objective itself allowing for an increase in the front aperture of the objective and corresponding enhancement of the solid angle of collected emission by an order of magnitude over existing designs.

Reducing the complexity of the software design process with object-oriented design

NASA Technical Reports Server (NTRS)

Schuler, M. P.

1991-01-01

Designing software is a complex process. How object-oriented design (OOD), coupled with formalized documentation and tailored object diagraming techniques, can reduce the complexity of the software design process is described and illustrated. The described OOD methodology uses a hierarchical decomposition approach in which parent objects are decomposed into layers of lower level child objects. A method of tracking the assignment of requirements to design components is also included. Increases in the reusability, portability, and maintainability of the resulting products are also discussed. This method was built on a combination of existing technology, teaching experience, consulting experience, and feedback from design method users. The discussed concepts are applicable to hierarchal OOD processes in general. Emphasis is placed on improving the design process by documenting the details of the procedures involved and incorporating improvements into those procedures as they are developed.

Structural Optimization for Reliability Using Nonlinear Goal Programming

NASA Technical Reports Server (NTRS)

El-Sayed, Mohamed E.

1999-01-01

This report details the development of a reliability based multi-objective design tool for solving structural optimization problems. Based on two different optimization techniques, namely sequential unconstrained minimization and nonlinear goal programming, the developed design method has the capability to take into account the effects of variability on the proposed design through a user specified reliability design criterion. In its sequential unconstrained minimization mode, the developed design tool uses a composite objective function, in conjunction with weight ordered design objectives, in order to take into account conflicting and multiple design criteria. Multiple design criteria of interest including structural weight, load induced stress and deflection, and mechanical reliability. The nonlinear goal programming mode, on the other hand, provides for a design method that eliminates the difficulty of having to define an objective function and constraints, while at the same time has the capability of handling rank ordered design objectives or goals. For simulation purposes the design of a pressure vessel cover plate was undertaken as a test bed for the newly developed design tool. The formulation of this structural optimization problem into sequential unconstrained minimization and goal programming form is presented. The resulting optimization problem was solved using: (i) the linear extended interior penalty function method algorithm; and (ii) Powell's conjugate directions method. Both single and multi-objective numerical test cases are included demonstrating the design tool's capabilities as it applies to this design problem.

Object Oriented Learning Objects

ERIC Educational Resources Information Center

Morris, Ed

2005-01-01

We apply the object oriented software engineering (OOSE) design methodology for software objects (SOs) to learning objects (LOs). OOSE extends and refines design principles for authoring dynamic reusable LOs. Our learning object class (LOC) is a template from which individualised LOs can be dynamically created for, or by, students. The properties…

Common modular avionics - Partitioning and design philosophy

NASA Astrophysics Data System (ADS)

Scott, D. M.; Mulvaney, S. P.

The design objectives and definition criteria for common modular hardware that will perform digital processing functions in multiple avionic subsystems are examined. In particular, attention is given to weapon system-level objectives, such as increased supportability, reduced life cycle costs, and increased upgradability. These objectives dictate the following overall modular design goals: reduce test equipment requirements; have a large number of subsystem applications; design for architectural growth; and standardize for technology transparent implementations. Finally, specific partitioning criteria are derived on the basis of the weapon system-level objectives and overall design goals.

Assessing Students' Structured Programming Skills with Java: The "Blue, Berry, and Blueberry" Assignment

ERIC Educational Resources Information Center

Zhang, Xihui

2010-01-01

Java is an object-oriented programming language. From a software engineering perspective, object-oriented design and programming is used at the architectural design, and structured design and programming is used at the detailed design within methods. As such, structured programming skills are fundamental to more advanced object-oriented…

Integrated design of the CSI evolutionary structure: A verification of the design methodology

NASA Technical Reports Server (NTRS)

Maghami, Peiman G.; Joshi, S. M.; Elliott, Kenny B.; Walz, J. E.

1993-01-01

One of the main objectives of the Controls-Structures Interaction (CSI) program is to develop and evaluate integrated controls-structures design methodology for flexible space structures. Thus far, integrated design methodologies for a class of flexible spacecraft, which require fine attitude pointing and vibration suppression with no payload articulation, have been extensively investigated. Various integrated design optimization approaches, such as single-objective optimization, and multi-objective optimization, have been implemented with an array of different objectives and constraints involving performance and cost measures such as total mass, actuator mass, steady-state pointing performance, transient performance, control power, and many more. These studies have been performed using an integrated design software tool (CSI-DESIGN CODE) which is under development by the CSI-ADM team at the NASA Langley Research Center. To date, all of these studies, irrespective of the type of integrated optimization posed or objectives and constraints used, have indicated that integrated controls-structures design results in an overall spacecraft design which is considerably superior to designs obtained through a conventional sequential approach. Consequently, it is believed that validation of some of these results through fabrication and testing of a structure which is designed through an integrated design approach is warranted. The objective of this paper is to present and discuss the efforts that have been taken thus far for the validation of the integrated design methodology.

Object-oriented design tools for supramolecular devices and biomedical nanotechnology.

PubMed

Lee, Stephen C; Bhalerao, Khaustaub; Ferrari, Mauro

2004-05-01

Nanotechnology provides multifunctional agents for in vivo use that increasingly blur the distinction between pharmaceuticals and medical devices. Realization of such therapeutic nanodevices requires multidisciplinary effort that is difficult for individual device developers to sustain, and identification of appropriate collaborations outside ones own field can itself be challenging. Further, as in vivo nanodevices become increasingly complex, their design will increasingly demand systems level thinking. System engineering tools such as object-oriented analysis, object-oriented design (OOA/D) and unified modeling language (UML) are applicable to nanodevices built from biological components, help logically manage the knowledge needed to design them, and help identify useful collaborative relationships for device designers. We demonstrate the utility of these systems engineering tools by reverse engineering an existing molecular device (the bacmid molecular cloning system) using them, and illustrate how object-oriented approaches identify fungible components (objects) in nanodevices in a way that facilitates design of families of related devices, rather than single inventions. We also explore the utility of object-oriented approaches for design of another class of therapeutic nanodevices, vaccines. While they are useful for design of current nanodevices, the power of systems design tools for biomedical nanotechnology will become increasingly apparent as the complexity and sophistication of in vivo nanosystems increases. The nested, hierarchical nature of object-oriented approaches allows treatment of devices as objects in higher-order structures, and so will facilitate concatenation of multiple devices into higher-order, higher-function nanosystems.

Moving into a new era of periodontal genetic studies: relevance of large case-control samples using severe phenotypes for genome-wide association studies.

PubMed

Vaithilingam, R D; Safii, S H; Baharuddin, N A; Ng, C C; Cheong, S C; Bartold, P M; Schaefer, A S; Loos, B G

2014-12-01

Studies to elucidate the role of genetics as a risk factor for periodontal disease have gone through various phases. In the majority of cases, the initial 'hypothesis-dependent' candidate-gene polymorphism studies did not report valid genetic risk loci. Following a large-scale replication study, these initially positive results are believed to be caused by type 1 errors. However, susceptibility genes, such as CDKN2BAS (Cyclin Dependend KiNase 2B AntiSense RNA; alias ANRIL [ANtisense Rna In the Ink locus]), glycosyltransferase 6 domain containing 1 (GLT6D1) and cyclooxygenase 2 (COX2), have been reported as conclusive risk loci of periodontitis. The search for genetic risk factors accelerated with the advent of 'hypothesis-free' genome-wide association studies (GWAS). However, despite many different GWAS being performed for almost all human diseases, only three GWAS on periodontitis have been published - one reported genome-wide association of GLT6D1 with aggressive periodontitis (a severe phenotype of periodontitis), whereas the remaining two, which were performed on patients with chronic periodontitis, were not able to find significant associations. This review discusses the problems faced and the lessons learned from the search for genetic risk variants of periodontitis. Current and future strategies for identifying genetic variance in periodontitis, and the importance of planning a well-designed genetic study with large and sufficiently powered case-control samples of severe phenotypes, are also discussed. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior.

PubMed

Hirschberg, Cosima; Boetker, Johan P; Rantanen, Jukka; Pein-Hackelbusch, Miriam

2018-02-01

There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries; overall goal was to assess mixing process of powder blends at small-scale with a combination of spectroscopic and mechanical monitoring. As part of the segregation evaluation studies, the flowability of three different paracetamol/filler-blends at different ratios was investigated, inter alia to define the percolation thresholds. Blends with a paracetamol wt% above the percolation threshold were subsequently investigated in relation to their segregation behavior. Rapid prototyping using 3D printing allowed designing two funnels with tailored flow behavior (funnel flow) of model formulations, which could be monitored with an in-line near-infrared (NIR) spectrometer. Calculating the root mean square (RMS) of the scores of the two first principal components of the NIR spectra visualized spectral variation as a function of process time. In a same setup, mechanical properties (basic flow energy) of the powder blend were monitored during blending. Rapid prototyping allowed for fast modification of powder testing geometries and easy interfacing with process analytical tools, opening new possibilities for more detailed powder characterization.

Statistical considerations in monitoring birds over large areas

USGS Publications Warehouse

Johnson, D.H.

2000-01-01

The proper design of a monitoring effort depends primarily on the objectives desired, constrained by the resources available to conduct the work. Typically, managers have numerous objectives, such as determining abundance of the species, detecting changes in population size, evaluating responses to management activities, and assessing habitat associations. A design that is optimal for one objective will likely not be optimal for others. Careful consideration of the importance of the competing objectives may lead to a design that adequately addresses the priority concerns, although it may not be optimal for any individual objective. Poor design or inadequate sample sizes may result in such weak conclusions that the effort is wasted. Statistical expertise can be used at several stages, such as estimating power of certain hypothesis tests, but is perhaps most useful in fundamental considerations of describing objectives and designing sampling plans.

A Study on the Difficulties of Learning Phase Transition in Object-Oriented Analysis and Design from the Viewpoint of Semantic Distance

ERIC Educational Resources Information Center

Shin, Shin-Shing

2015-01-01

Students in object-oriented analysis and design (OOAD) courses typically encounter difficulties transitioning from object-oriented analysis (OOA) to logical design (OOLD). This study conducted an empirical experiment to examine these learning difficulties by evaluating differences between OOA-to-OOLD and OOLD-to-object-oriented-physical-design…

Chapter 18: Web-based Tools - NED VO Services

NASA Astrophysics Data System (ADS)

Mazzarella, J. M.; NED Team

The NASA/IPAC Extragalactic Database (NED) is a thematic, web-based research facility in widespread use by scientists, educators, space missions, and observatory operations for observation planning, data analysis, discovery, and publication of research about objects beyond our Milky Way galaxy. NED is a portal into a systematic fusion of data from hundreds of sky surveys and tens of thousands of research publications. The contents and services span the entire electromagnetic spectrum from gamma rays through radio frequencies, and are continuously updated to reflect the current literature and releases of large-scale sky survey catalogs. NED has been on the Internet since 1990, growing in content, automation and services with the evolution of information technology. NED is the world's largest database of crossidentified extragalactic objects. As of December 2006, the system contains approximately 10 million objects and 15 million multi-wavelength cross-IDs. Over 4 thousand catalogs and published lists covering the entire electromagnetic spectrum have had their objects cross-identified or associated, with fundamental data parameters federated for convenient queries and retrieval. This chapter describes the interoperability of NED services with other components of the Virtual Observatory (VO). Section 1 is a brief overview of the primary NED web services. Section 2 provides a tutorial for using NED services currently available through the NVO Registry. The "name resolver" provides VO portals and related internet services with celestial coordinates for objects specified by catalog identifier (name); any alias can be queried because this service is based on the source cross-IDs established by NED. All major services have been updated to provide output in VOTable (XML) format that can be accessed directly from the NED web interface or using the NVO registry. These include access to images via SIAP, Cone- Search queries, and services providing fundamental, multi-wavelength extragalactic data such as positions, redshifts, photometry and spectral energy distributions (SEDs), and sizes (all with references and uncertainties when available). Section 3 summarizes the advantages of accessing the NED "name resolver" and other NED services via the web to replace the legacy "server mode" custom data structure previously available through a function library provided only in the C programming language. Section 4 illustrates visualization via VOPlot of an SED and the spatial distribution of sources from a NED All-Sky (By Parameters) query. Section 5 describes the new NED Spectral Archive, illustrating how VOTables are being used to standardize the data and metadata as well as the physical units of spectra made available by authors of journal articles and producers of major survey archives; quick-look spectral analysis through convenient interoperability with the SpecView (STScI) Java applet is also shown. Section 6 closes with a summary of the capabilities described herein, which greatly simplify interoperability of NED with other components of the VO, enabling new opportunities for discovery, visualization, and analysis of multiwavelength data.

Tradeoff studies in multiobjective insensitive design of airplane control systems

NASA Technical Reports Server (NTRS)

Schy, A. A.; Giesy, D. P.

1983-01-01

A computer aided design method for multiobjective parameter-insensitive design of airplane control systems is described. Methods are presented for trading off nominal values of design objectives against sensitivities of the design objectives to parameter uncertainties, together with guidelines for designer utilization of the methods. The methods are illustrated by application to the design of a lateral stability augmentation system for two supersonic flight conditions of the Shuttle Orbiter. Objective functions are conventional handling quality measures and peak magnitudes of control deflections and rates. The uncertain parameters are assumed Gaussian, and numerical approximations of the stochastic behavior of the objectives are described. Results of applying the tradeoff methods to this example show that stochastic-insensitive designs are distinctly different from deterministic multiobjective designs. The main penalty for achieving significant decrease in sensitivity is decreased speed of response for the nominal system.

Construction of the Dependence Matrix Based on the TRIZ Contradiction Matrix in OOD

NASA Astrophysics Data System (ADS)

Ma, Jianhong; Zhang, Quan; Wang, Yanling; Luo, Tao

In the Object-Oriented software design (OOD), design of the class and object, definition of the classes’ interface and inheritance levels and determination of dependent relations have a serious impact on the reusability and flexibility of the system. According to the concrete problems of design, how to select the right solution from the hundreds of the design schemas which has become the focus of attention of designers. After analyzing lots of software design schemas in practice and Object-Oriented design patterns, this paper constructs the dependence matrix of Object-Oriented software design filed, referring to contradiction matrix of TRIZ (Theory of Inventive Problem Solving) proposed by the former Soviet Union innovation master Altshuller. As the practice indicates, it provides a intuitive, common and standardized method for designers to choose the right design schema. Make research and communication more effectively, and also improve the software development efficiency and software quality.

MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis

PubMed Central

Musa, Julian; Aynaud, Marie-Ming; Mirabeau, Olivier; Delattre, Olivier; Grünewald, Thomas GP

2017-01-01

Limitless cell proliferation, evasion from apoptosis, dedifferentiation, metastatic spread and therapy resistance: all these properties of a cancer cell contribute to its malignant phenotype and affect patient outcome. MYBL2 (alias B-Myb) is a transcription factor of the MYB transcription factor family and a physiological regulator of cell cycle progression, cell survival and cell differentiation. When deregulated in cancer cells, MYBL2 mediates the deregulation of these properties. In fact, MYBL2 is overexpressed and associated with poor patient outcome in numerous cancer entities. MYBL2 and players of its downstream transcriptional network can be used as prognostic and/or predictive biomarkers as well as potential therapeutic targets to offer less toxic and more specific anti-cancer therapies in future. In this review, we summarize current knowledge on the physiological roles of MYBL2 and highlight the impact of its deregulation on cancer initiation and progression. PMID:28640249

The scheme for evaluation of isotopic composition of fast reactor core in closed nuclear fuel cycle

NASA Astrophysics Data System (ADS)

Saldikov, I. S.; Ternovykh, M. Yu; Fomichenko, P. A.; Gerasimov, A. S.

2017-01-01

The PRORYV (i.e. «Breakthrough» in Russian) project is currently under development. Within the framework of this project, fast reactors BN-1200 and BREST-OD-300 should be built to, inter alia, demonstrate possibility of the closed nuclear fuel cycle technologies with plutonium as a main source of power. Russia has a large inventory of plutonium which was accumulated in the result of reprocessing of spent fuel of thermal power reactors and conversion of nuclear weapons. This kind of plutonium will be used for development of initial fuel assemblies for fast reactors. To solve the closed nuclear fuel modeling tasks REPRORYV code was developed. It simulates the mass flow for nuclides in the closed fuel cycle. This paper presents the results of modeling of a closed nuclear fuel cycle, nuclide flows considering the influence of the uncertainty on the outcome of neutron-physical characteristics of the reactor.

Is Africa a 'Graveyard' for Linear Accelerators?

PubMed

Reichenvater, H; Matias, L Dos S

2016-12-01

Linear accelerator downtimes are common and problematic in many African countries and may jeopardise the outcome of affected radiation treatments. The predicted increase in cancer incidence and prevalence on the African continent will require, inter alia, improved response with regard to a reduction in linear accelerator downtimes. Here we discuss the problems associated with the maintenance and repair of linear accelerators and propose alternative solutions relevant for local conditions in African countries. The paper is based on about four decades of experience in capacity building, installing, commissioning, calibrating, servicing and repairing linear accelerators in Africa, where about 40% of the low and middle income countries in the world are geographically located. Linear accelerators can successfully be operated, maintained and repaired in African countries provided proper maintenance and repair plans are put in place and executed. Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

An explorative study of experiences of healthcare providers posing as simulated care receivers in a 'care-ethical' lab.

PubMed

Vanlaere, Linus; Timmermann, Madeleine; Stevens, Marleen; Gastmans, Chris

2012-01-01

In recent approaches to ethics, the personal involvement of health care providers and their empathy are perceived as important elements of an overall ethical ability. Experiential working methods are used in ethics education to foster, inter alia, empathy. In 2008, the care-ethics lab 'sTimul' was founded in Flanders, Belgium, to provide training that focuses on improving care providers' ethical abilities through experiential working simulations. The curriculum of sTimul focuses on empathy sessions, aimed at care providers' empathic skills. The present study provides better insight into how experiential learning specifically targets the empathic abilities of care providers. Providing contrasting experiences that affect the care providers' self-reflection seems a crucial element in this study. Further research is needed to provide more insight into how empathy leads to long-term changes in behaviour.

Chemotaxis with logistic source

NASA Astrophysics Data System (ADS)

Winkler, Michael

2008-12-01

We consider the chemotaxis system in a smooth bounded domain , where [chi]>0 and g generalizes the logistic function g(u)=Au-bu[alpha] with [alpha]>1, A[greater-or-equal, slanted]0 and b>0. A concept of very weak solutions is introduced, and global existence of such solutions for any nonnegative initial data u0[set membership, variant]L1([Omega]) is proved under the assumption that . Moreover, boundedness properties of the constructed solutions are studied. Inter alia, it is shown that if b is sufficiently large and u0[set membership, variant]L[infinity]([Omega]) has small norm in L[gamma]([Omega]) for some then the solution is globally bounded. Finally, in the case that additionally holds, a bounded set in L[infinity]([Omega]) can be found which eventually attracts very weak solutions emanating from arbitrary L1 initial data. The paper closes with numerical experiments that illustrate some of the theoretically established results.

Multimode optomechanical system in the quantum regime

PubMed Central

Nielsen, William Hvidtfelt Padkær; Tsaturyan, Yeghishe; Møller, Christoffer Bo; Polzik, Eugene S.; Schliesser, Albert

2017-01-01

We realize a simple and robust optomechanical system with a multitude of long-lived (Q > 107) mechanical modes in a phononic-bandgap shielded membrane resonator. An optical mode of a compact Fabry–Perot resonator detects these modes’ motion with a measurement rate (96 kHz) that exceeds the mechanical decoherence rates already at moderate cryogenic temperatures (10 K). Reaching this quantum regime entails, inter alia, quantum measurement backaction exceeding thermal forces and thus strong optomechanical quantum correlations. In particular, we observe ponderomotive squeezing of the output light mediated by a multitude of mechanical resonator modes, with quantum noise suppression up to −2.4 dB (−3.6 dB if corrected for detection losses) and bandwidths ≲90 kHz. The multimode nature of the membrane and Fabry–Perot resonators will allow multimode entanglement involving electromagnetic, mechanical, and spin degrees of freedom. PMID:27999182

Attitudes toward rape and victims of rape: a test of the feminist theory in Ghana.

PubMed

Boakye, Kofi E

2009-10-01

This study explores the usefulness of the feminist theory in explaining attitudes toward rape and victims of rape in Ghana. The feminist theory of rape posits, inter alia, that patriarchy and gender inequality are major factors in the aetiology of rape and attitudes toward rape and that underlying patriarchy and gender inequality are gender stereotypes and false beliefs (myths) about rape, rapists, and victims of rape. Thus, the theory suggests a relationship between rape myths and less favorable attitudes toward rape and victims of rape. Results from a survey conducted in Ghana show some support for the feminist theory of rape: There is evidence of rape myth acceptance in Ghana; gender is significant in predicting levels of rape myth acceptance; and finally, education or profession and age, but not religion, are associated with levels of rape myth acceptance in a predictable way.

Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor

NASA Astrophysics Data System (ADS)

Shin, Weon Sup; Han, Jiyou; Kumar, Rajesh; Lee, Gyung Gyu; Sessler, Jonathan L.; Kim, Jong-Hoon; Kim, Jong Seung

2016-07-01

We report here a tumor-targeting masked phototherapeutic agent 1 (PT-1). This system contains SN-38—a prodrug of the topoisomerase I inhibitor irinotecan. Topoisomerase I is a vital enzyme that controls DNA topology during replication, transcription, and recombination. An elevated level of topoisomerase I is found in many carcinomas, making it an attractive target for the development of effective anticancer drugs. In addition, PT-1 contains both a photo-triggered moiety (nitrovanillin) and a cancer targeting unit (biotin). Upon light activation in cancer cells, PT-1 interferes with DNA re-ligation, diminishes the expression of topoisomerase I, and enhances the expression of inter alia mitochondrial apoptotic genes, death receptors, and caspase enzymes, inducing DNA damage and eventually leading to apoptosis. In vitro and in vivo studies showed significant inhibition of cancer growth and the hybrid system PT-1 thus shows promise as a programmed photo-therapeutic (“phototheranostic”).

Redox-active charge carriers of conducting polymers as a tuner of conductivity and its potential window

PubMed Central

Park, Han-Saem; Ko, Seo-Jin; Park, Jeong-Seok; Kim, Jin Young; Song, Hyun-Kon

2013-01-01

Electric conductivity of conducting polymers has been steadily enhanced towards a level worthy of being called its alias, “synthetic metal”. PEDOT:PSS (poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate)), as a representative conducting polymer, recently reached around 3,000 S cm−1, the value to open the possibility to replace transparent conductive oxides. The leading strategy to drive the conductivity increase is solvent annealing in which aqueous solution of PEDOT:PSS is treated with an assistant solvent such as DMSO (dimethyl sulfoxide). In addition to the conductivity enhancement, we found that the potential range in which PEDOT:PSS is conductive is tuned wider into a negative potential direction by the DMSO-annealing. Also, the increase in a redox-active fraction of charge carriers is proposed to be responsible for the enhancement of conductivity in the solvent annealing process. PMID:23949091

Variability in dentofacial phenotypes in four families with WNT10A mutations

PubMed Central

Vink, Christian P; Ockeloen, Charlotte W; ten Kate, Sietske; Koolen, David A; Ploos van Amstel, Johannes Kristian; Kuijpers-Jagtman, Anne-Marie; van Heumen, Celeste C; Kleefstra, Tjitske; Carels, Carine E L

2014-01-01

This article describes the inter- and intra-familial phenotypic variability in four families with WNT10A mutations. Clinical characteristics of the patients range from mild to severe isolated tooth agenesis, over mild symptoms of ectodermal dysplasia, to more severe syndromic forms like odonto-onycho-dermal dysplasia (OODD) and Schöpf–Schulz–Passarge syndrome (SSPS). Recurrent WNT10A mutations were identified in all affected family members and the associated symptoms are presented with emphasis on the dentofacial phenotypes obtained with inter alia three-dimensional facial stereophotogrammetry. A comprehensive overview of the literature regarding WNT10A mutations, associated conditions and developmental defects is presented. We conclude that OODD and SSPS should be considered as variable expressions of the same WNT10A genotype. In all affected individuals, a dished-in facial appearance was observed which might be helpful in the clinical setting as a clue to the underlying genetic etiology. PMID:24398796

Quality care for persons experiencing dementia: the significance of relational ethics.

PubMed

Sellevold, Gerd S; Egede-Nissen, Veslemøy; Jakobsen, Rita; Sørlie, Venke

2013-05-01

The degree of success in creating quality care for people suffering from dementia is limited despite extensive research. This article describes healthcare providers' experience with the ethical challenges and possibilities in the relationship with patients suffering from dementia and its impact on quality care. The material is based on qualitative, in-depth individual narrative interviews with 12 professional healthcare providers from two different nursing homes. The transcribed interview texts were subjected to a phenomenological-hermeneutical interpretation. To provide quality care to patients with dementia, the healthcare providers emphasized the importance of sensing and understanding the patients' emotional and bodily expressions through sentient attentiveness and recognition of the patient as a person. They also described reciprocity of expressions in the relationship where the patient recognized them both as persons and healthcare providers. The analyses of the findings are, inter alia, discussed in light of Løgstrup's relational philosophy of ethics.

Anomalous Hydrodynamics and Normal Fluids in Rapidly Rotating Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Bourne, A.; Wilkin, N. K.; Gunn, J. M. F.

2006-06-01

In rapidly rotating condensed Bose systems we show that there is a regime of anomalous hydrodynamics which coincides with the mean field quantum Hall regime. A consequence is the absence of a normal fluid in any conventional sense. However, even the superfluid hydrodynamics is not described by conventional Bernoulli and continuity equations. We show that there are constraints which connect spatial variations of density and phase and that the vortex positions are not the simplest description of the dynamics. We demonstrate, inter alia, a simple relation between vortices and surface waves. We show that the surface waves can emulate a “normal fluid,” allowing dissipation by energy and angular momentum absorbtion from vortex motion in the trap. The time scale is sensitive to the initial configuration, which can lead to long-lived vortex patches—perhaps related to those observed at JILA.

A Fourier transform with speed improvements for microprocessor applications

NASA Technical Reports Server (NTRS)

Lokerson, D. C.; Rochelle, R.

1980-01-01

A fast Fourier transform algorithm for the RCA 1802microprocessor was developed for spacecraft instrument applications. The computations were tailored for the restrictions an eight bit machine imposes. The algorithm incorporates some aspects of Walsh function sequency to improve operational speed. This method uses a register to add a value proportional to the period of the band being processed before each computation is to be considered. If the result overflows into the DF register, the data sample is used in computation; otherwise computation is skipped. This operation is repeated for each of the 64 data samples. This technique is used for both sine and cosine portions of the computation. The processing uses eight bit data, but because of the many computations that can increase the size of the coefficient, floating point form is used. A method to reduce the alias problem in the lower bands is also described.

Broad spectrum antiviral agent ribavirin inhibits capping of mRNA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goswami, B.B.; Borek, E.; Sharma, O.K.

1979-08-13

Ribavirin (1-..beta..-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a broad spectrum antiviral substance active against a wide range of both DNA and RNA viruses. It is, however, virtually inactive against polio virus. Its pharmacological mechanism of action was obscure. A possible common target for a chemotherapeutic agent in both DNA and RNA viruses is the capping reaction of mRNAs which inter alia involves the formation of a guanine pyrophosphate structure at the 5' terminus by mRNA guanylyl transferase. We have observed that Ribavirin triphosphate is a potent competitive inhibitor of the capping guanylation of viral mRNA. This finding could account for the antiviral potency ofmore » the drug against both DNA and RNA viruses and its ineffectiveness against a virus in which the mRNAs derived from them are not capped.« less

Novel PCR-Restriction Fragment Length Polymorphism Method for Determining Serotypes or Serogroups of Streptococcus pneumoniae Isolates

PubMed Central

Batt, Sarah L.; Charalambous, Bambos M.; McHugh, Timothy D.; Martin, Siobhan; Gillespie, Stephen H.

2005-01-01

Serotyping Streptococcus pneumoniae is a technique generally confined to reference laboratories, as purchasing pneumococcal antisera is a huge investment. Many attempts have been made to modify serological agglutination techniques to make them more accessible, and more recently developments in serotyping have focused on molecular techniques. This paper describes a PCR assay which amplifies the entire capsulation locus between dexB and aliA. Amplicons are digested to produce serotype-specific patterns. We have shown, using 81 epidemiologically unrelated strains representing 46 different serotypes, that the patterns correlate with a 90 to 100% similarity range for the same serotype or serogroup. Prospective testing of 73 isolates of unknown serotype confirmed reliable serotype attribution, and serotype profiles are reproducible on repeated testing. Once our database contains all 90 serotypes, this technique should be fully portable, cost-effective, and useful in any laboratory with sufficient molecular experience. PMID:15956380

Development and application of General Purpose Data Acquisition Shell (GPDAS) at advanced photon source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Youngjoo; Kim, Keeman.

1991-01-01

An operating system shell GPDAS (General Purpose Data Acquisition Shell) on MS-DOS-based microcomputers has been developed to provide flexibility in data acquisition and device control for magnet measurements at the Advanced Photon Source. GPDAS is both a command interpreter and an integrated script-based programming environment. It also incorporates the MS-DOS shell to make use of the existing utility programs for file manipulation and data analysis. Features include: alias definition, virtual memory, windows, graphics, data and procedure backup, background operation, script programming language, and script level debugging. Data acquisition system devices can be controlled through IEEE488 board, multifunction I/O board, digitalmore » I/O board and Gespac crate via Euro G-64 bus. GPDAS is now being used for diagnostics R D and accelerator physics studies as well as for magnet measurements. Their hardware configurations will also be discussed. 3 refs., 3 figs.« less

Maximum rates of climate change are systematically underestimated in the geological record.

PubMed

Kemp, David B; Eichenseer, Kilian; Kiessling, Wolfgang

2015-11-10

Recently observed rates of environmental change are typically much higher than those inferred for the geological past. At the same time, the magnitudes of ancient changes were often substantially greater than those established in recent history. The most pertinent disparity, however, between recent and geological rates is the timespan over which the rates are measured, which typically differ by several orders of magnitude. Here we show that rates of marked temperature changes inferred from proxy data in Earth history scale with measurement timespan as an approximate power law across nearly six orders of magnitude (10(2) to >10(7) years). This scaling reveals how climate signals measured in the geological record alias transient variability, even during the most pronounced climatic perturbations of the Phanerozoic. Our findings indicate that the true attainable pace of climate change on timescales of greatest societal relevance is underestimated in geological archives.

Proposal for founding mistrustful quantum cryptography on coin tossing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kent, Adrian; Hewlett-Packard Laboratories, Filton Road, Stoke Gifford, Bristol BS34 8QZ,

2003-07-01

A significant branch of classical cryptography deals with the problems which arise when mistrustful parties need to generate, process, or exchange information. As Kilian showed a while ago, mistrustful classical cryptography can be founded on a single protocol, oblivious transfer, from which general secure multiparty computations can be built. The scope of mistrustful quantum cryptography is limited by no-go theorems, which rule out, inter alia, unconditionally secure quantum protocols for oblivious transfer or general secure two-party computations. These theorems apply even to protocols which take relativistic signaling constraints into account. The best that can be hoped for, in general, aremore » quantum protocols which are computationally secure against quantum attack. Here a method is described for building a classically certified bit commitment, and hence every other mistrustful cryptographic task, from a secure coin-tossing protocol. No security proof is attempted, but reasons are sketched why these protocols might resist quantum computational attack.« less

Cognitive Task Analysis of Experts in Designing Multimedia Learning Object Guideline (M-LOG)

ERIC Educational Resources Information Center

Razak, Rafiza Abdul; Palanisamy, Punithavathy

2013-01-01

The purpose of this study was to design and develop a set of guidelines for multimedia learning objects to inform instructional designers (IDs) about the procedures involved in the process of content analysis. This study was motivated by the absence of standardized procedures in the beginning phase of the multimedia learning object design which is…

Multi-objective engineering design using preferences

NASA Astrophysics Data System (ADS)

Sanchis, J.; Martinez, M.; Blasco, X.

2008-03-01

System design is a complex task when design parameters have to satisy a number of specifications and objectives which often conflict with those of others. This challenging problem is called multi-objective optimization (MOO). The most common approximation consists in optimizing a single cost index with a weighted sum of objectives. However, once weights are chosen the solution does not guarantee the best compromise among specifications, because there is an infinite number of solutions. A new approach can be stated, based on the designer's experience regarding the required specifications and the associated problems. This valuable information can be translated into preferences for design objectives, and will lead the search process to the best solution in terms of these preferences. This article presents a new method, which enumerates these a priori objective preferences. As a result, a single objective is built automatically and no weight selection need be performed. Problems occuring because of the multimodal nature of the generated single cost index are managed with genetic algorithms (GAs).

Freeform object design and simultaneous manufacturing

NASA Astrophysics Data System (ADS)

Zhang, Wei; Zhang, Weihan; Lin, Heng; Leu, Ming C.

2003-04-01

Today's product design, especially the consuming product design, focuses more and more on individuation, originality, and the time to market. One way to meet these challenges is using the interactive and creationary product design methods and rapid prototyping/rapid tooling. This paper presents a novel Freeform Object Design and Simultaneous Manufacturing (FODSM) method that combines the natural interaction feature in the design phase and simultaneous manufacturing feature in the prototyping phase. The natural interactive three-dimensional design environment is achieved by adopting virtual reality technology. The geometry of the designed object is defined through the process of "virtual sculpting" during which the designer can touch and visualize the designed object and can hear the virtual manufacturing environment noise. During the designing process, the computer records the sculpting trajectories and automatically translates them into NC codes so as to simultaneously machine the designed part. The paper introduced the principle, implementation process, and key techniques of the new method, and compared it with other popular rapid prototyping methods.

40 CFR 96.114 - Objections concerning CAIR designated representative.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Objections concerning CAIR designated... IMPLEMENTATION PLANS CAIR Designated Representative for CAIR NOX Sources § 96.114 Objections concerning CAIR... communication submitted to the permitting authority or the Administrator concerning the authorization, or any...

40 CFR 96.214 - Objections concerning CAIR designated representative.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Objections concerning CAIR designated... IMPLEMENTATION PLANS CAIR Designated Representative for CAIR SO2 Sources § 96.214 Objections concerning CAIR... communication submitted to the permitting authority or the Administrator concerning the authorization, or any...

Adapting the Mathematical Task Framework to Design Online Didactic Objects

ERIC Educational Resources Information Center

Bowers, Janet; Bezuk, Nadine; Aguilar, Karen

2011-01-01

Designing didactic objects involves imagining how students can conceive of specific mathematical topics and then imagining what types of classroom discussions could support these mental constructions. This study investigated whether it was possible to design Java applets that might serve as didactic objects to support online learning where…

Object-oriented design for accelerator control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stok, P.D.V. van der; Berk, F. van den; Deckers, R.

1994-02-01

An object-oriented design for the distributed computer control system of the accelerator ring EUTERPE is presented. Because of the experimental nature of the ring, flexibility is of the utmost importance. The object-oriented principles have contributed considerably to the flexibility of the design incorporating multiple views, multi-level access and distributed surveillance.

78 FR 43960 - Culturally Significant Objects Imported for Exhibition Determinations: “Dante Ferretti: Design...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

... DEPARTMENT OF STATE [Public Notice 8385] Culturally Significant Objects Imported for Exhibition Determinations: ``Dante Ferretti: Design and Construction for Cinema'' SUMMARY: Notice is hereby given of the... that the objects to be included in the exhibition ``Dante Ferretti: Design and Construction for Cinema...

A Software Designed For STP Data Plot and Analysis Based on Object-oriented Methodology

NASA Astrophysics Data System (ADS)

Lina, L.; Murata, K.

2006-12-01

In the present study, we design a system that is named "STARS (Solar-Terrestrial data Analysis and Reference System)". The STARS provides a research environment that researchers can refer to and analyse a variety of data with single software. This software design is based on the OMT (Object Modeling Technique). The OMT is one of the object-oriented techniques, which has an advantage in maintenance improvement, reuse and long time development of a system. At the Center for Information Technology, Ehime University, after our designing of the STARS, we have already started implementing the STARS. The latest version of the STARS, the STARS5, was released in 2006. Any user can download the system from our WWW site (http:// www.infonet.cite.ehime-u.ac.jp/STARS). The present paper is mainly devoted to the design of a data analysis software system. Through our designing, we paid attention so that the design is flexible and applicable when other developers design software for the similar purpose. If our model is so particular only for our own purpose, it would be useless for other developers. Through our design of the domain object model, we carefully removed the parts, which depend on the system resources, e.g. hardware and software. We put the dependent parts into the application object model. In the present design, therefore, the domain object model and the utility object model are independent of computer resource. This helps anther developer to construct his/her own system based the present design. They simply modify their own application object models according to their system resource. This division of the design between dependent and independent part into three object models is one of the advantages in the OMT. If the design of software is completely done along with the OMT, implementation is rather simple and automatic: developers simply map their designs on our programs. If one creates "ganother STARS" with other programming language such as Java, the programmer simply follows the present system as long as the language is object-oriented language. Researchers would want to add their data into the STARS. In this case, they simply add their own data class in the domain object model. It is because any satellite data has properties such as time or date, which are inherited from the upper class. In this way, their effort is less than in other old methodologies. In the OMT, description format of the system is rather strictly standardized. When new developers take part in STARS project, they have only to understand each model to obtain the overview of the STARS. Then they follow this designs and documents to implement the system. The OMT makes a new comer easy to join into the project already running.

A framework for analyzing interdisciplinary tasks: implications for student learning and curricular design.

PubMed

Gouvea, Julia Svoboda; Sawtelle, Vashti; Geller, Benjamin D; Turpen, Chandra

2013-06-01

The national conversation around undergraduate science instruction is calling for increased interdisciplinarity. As these calls increase, there is a need to consider the learning objectives of interdisciplinary science courses and how to design curricula to support those objectives. We present a framework that can help support interdisciplinary design research. We developed this framework in an introductory physics for life sciences majors (IPLS) course for which we designed a series of interdisciplinary tasks that bridge physics and biology. We illustrate how this framework can be used to describe the variation in the nature and degree of interdisciplinary interaction in tasks, to aid in redesigning tasks to better align with interdisciplinary learning objectives, and finally, to articulate design conjectures that posit how different characteristics of these tasks might support or impede interdisciplinary learning objectives. This framework will be useful for both curriculum designers and education researchers seeking to understand, in more concrete terms, what interdisciplinary learning means and how integrated science curricula can be designed to support interdisciplinary learning objectives.

A Framework for Analyzing Interdisciplinary Tasks: Implications for Student Learning and Curricular Design

PubMed Central

Gouvea, Julia Svoboda; Sawtelle, Vashti; Geller, Benjamin D.; Turpen, Chandra

2013-01-01

The national conversation around undergraduate science instruction is calling for increased interdisciplinarity. As these calls increase, there is a need to consider the learning objectives of interdisciplinary science courses and how to design curricula to support those objectives. We present a framework that can help support interdisciplinary design research. We developed this framework in an introductory physics for life sciences majors (IPLS) course for which we designed a series of interdisciplinary tasks that bridge physics and biology. We illustrate how this framework can be used to describe the variation in the nature and degree of interdisciplinary interaction in tasks, to aid in redesigning tasks to better align with interdisciplinary learning objectives, and finally, to articulate design conjectures that posit how different characteristics of these tasks might support or impede interdisciplinary learning objectives. This framework will be useful for both curriculum designers and education researchers seeking to understand, in more concrete terms, what interdisciplinary learning means and how integrated science curricula can be designed to support interdisciplinary learning objectives. PMID:23737627

Performance Analysis of an Actor-Based Distributed Simulation

NASA Technical Reports Server (NTRS)

Schoeffler, James D.

1998-01-01

Object-oriented design of simulation programs appears to be very attractive because of the natural association of components in the simulated system with objects. There is great potential in distributing the simulation across several computers for the purpose of parallel computation and its consequent handling of larger problems in less elapsed time. One approach to such a design is to use "actors", that is, active objects with their own thread of control. Because these objects execute concurrently, communication is via messages. This is in contrast to an object-oriented design using passive objects where communication between objects is via method calls (direct calls when they are in the same address space and remote procedure calls when they are in different address spaces or different machines). This paper describes a performance analysis program for the evaluation of a design for distributed simulations based upon actors.

User's Manual for the New England Water-Use Data System (NEWUDS)

USGS Publications Warehouse

Horn, Marilee A.

2003-01-01

Water is used in a variety of ways that need to be understood for effective management of water resources. Water-use activities need to be categorized and included in a database management system to understand current water uses and to provide information to water-resource management policy decisionmakers. The New England Water-Use Data System (NEWUDS) is a complex database developed to store water-use information that allows water to be tracked from a point of water-use activity (called a 'Site'), such as withdrawal from a resource (reservoir or aquifer), to a second Site, such as distribution to a user (business or irrigator). NEWUDS conceptual model consists of 10 core entities: system, owner, address, location, site, data source, resource, conveyance, transaction/rate, and alias, with tables available to store user-defined details. Three components--site (with both a From Site and a To Site), a conveyance that connects them, and a transaction/rate associated with the movement of water over a specific time interval form the core of the basic NEWUDS network model. The most important step in correctly translating real-world water-use activities into a storable format in NEWUDS depends on choosing the appropriate sites and linking them correctly in a network to model the flow of water from the initial From Site to the final To Site. Ten water-use networks representing real-world activities are described--three withdrawal networks, three return networks, two user networks, two complex community-system networks. Ten case studies of water use, one for each network, also are included in this manual to illustrate how to compile, store, and retrieve the appropriate data. The sequence of data entry into tables is critical because there are many foreign keys. The recommended core entity sequence is (1) system, (2) owner, (3) address, (4) location, (5) site, (6) data source, (7) resource, (8) conveyance, (9) transaction, and (10) rate; with (11) alias and (12) user-defined detail subject areas populated as needed. After each step in data entry, quality-assurance queries should be run to ensure the data are correctly entered so that it can be retrieved accurately. The point of data storage is retrieval. Several retrieval queries that focus on retrieving only relevant data to specific questions are presented in this manual as examples for the NEWUDS user.

A Framework for the Flexible Content Packaging of Learning Objects and Learning Designs

ERIC Educational Resources Information Center

Lukasiak, Jason; Agostinho, Shirley; Burnett, Ian; Drury, Gerrard; Goodes, Jason; Bennett, Sue; Lockyer, Lori; Harper, Barry

2004-01-01

This paper presents a platform-independent method for packaging learning objects and learning designs. The method, entitled a Smart Learning Design Framework, is based on the MPEG-21 standard, and uses IEEE Learning Object Metadata (LOM) to provide bibliographic, technical, and pedagogical descriptors for the retrieval and description of learning…

An Analysis of Applications Development Systems for Remotely Sensed, Multispectral Data for the Earth Observations Division of the NASA Lyndon B. Johnson Space Center

NASA Technical Reports Server (NTRS)

Vanrooy, D. L.; Smith, R. M.; Lynn, M. S.

1974-01-01

An application development system (ADS) is examined for remotely sensed, multispectral data at the Earth Observations Division (EOD) at Johnson Space Center. Design goals are detailed, along with design objectives that an ideal system should contain. The design objectives were arranged according to the priorities of EOD's program objectives. Four systems available to EOD were then measured against the ideal ADS as defined by the design objectives and their associated priorities. This was accomplished by rating each of the systems on each of the design objectives. Utilizing the established priorities, it was determined how each system stood up as an ADS. Recommendations were made as to possible courses of action for EOD to pursue to obtain a more efficient ADS.

Designing a multi-objective, multi-support accuracy assessment of the 2001 National Land Cover Data (NLCD 2001) of the conterminous United States

USGS Publications Warehouse

Stehman, S.V.; Wickham, J.D.; Wade, T.G.; Smith, J.H.

2008-01-01

The database design and diverse application of NLCD 2001 pose significant challenges for accuracy assessment because numerous objectives are of interest, including accuracy of land-cover, percent urban imperviousness, percent tree canopy, land-cover composition, and net change. A multi-support approach is needed because these objectives require spatial units of different sizes for reference data collection and analysis. Determining a sampling design that meets the full suite of desirable objectives for the NLCD 2001 accuracy assessment requires reconciling potentially conflicting design features that arise from targeting the different objectives. Multi-stage cluster sampling provides the general structure to achieve a multi-support assessment, and the flexibility to target different objectives at different stages of the design. We describe the implementation of two-stage cluster sampling for the initial phase of the NLCD 2001 assessment, and identify gaps in existing knowledge where research is needed to allow full implementation of a multi-objective, multi-support assessment. ?? 2008 American Society for Photogrammetry and Remote Sensing.

Stylization levels of industrial design objects

NASA Astrophysics Data System (ADS)

Kukhta, M. S.; Sokolov, A. P.; Krauinsh, D. P.; Bouchard, C.

2017-01-01

The urgency of the research of form making problem in design is associated with the necessity of new understanding of visual culture and new approaches to design engineering representing the integration of artistic and designed problems. The aim of this research is to study the levels of stylization of design objects and dependance (relation) on the specific project objectives and existing technologies. On the ground of quantitative evaluation, the stylization measures are emphasized: figurative image, stylized image and abstract image. Theoretic conclusions are complemented by practical problem solution over creating openwork metal lantern. Variants of both the traditional mains supply of the lantern and the autonomic supply system based on solar energy were offered. The role of semantic factor, affecting the depth of perception of design objects semantic space, is represented in this paper.

Software Design for Interactive Graphic Radiation Treatment Simulation Systems*

PubMed Central

Kalet, Ira J.; Sweeney, Christine; Jacky, Jonathan

1990-01-01

We examine issues in the design of interactive computer graphic simulation programs for radiation treatment planning (RTP), as well as expert system programs that automate parts of the RTP process, in light of ten years of experience at designing, building and using such programs. An experiment in object-oriented design using standard Pascal shows that while some advantage is gained from the design, it is still difficult to achieve modularity and to integrate expert system components. A new design based on the Common LISP Object System (CLOS) is described. This series of designs for RTP software shows that this application benefits in specific ways from object-oriented design methods and appropriate languages and tools.

40 CFR 33.406 - May a recipient designate a lead agency for fair share objective negotiation purposes?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false May a recipient designate a lead agency for fair share objective negotiation purposes? 33.406 Section 33.406 Protection of Environment... recipient designate a lead agency for fair share objective negotiation purposes? If an Indian Tribal, State...

10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

Design, Development, and Validation of Learning Objects

ERIC Educational Resources Information Center

Nugent, Gwen; Soh, Leen-Kiat; Samal, Ashok

2006-01-01

A learning object is a small, stand-alone, mediated content resource that can be reused in multiple instructional contexts. In this article, we describe our approach to design, develop, and validate Shareable Content Object Reference Model (SCORM) compliant learning objects for undergraduate computer science education. We discuss the advantages of…

Miniature objective lens for array digital pathology: design improvement based on clinical evaluation

NASA Astrophysics Data System (ADS)

McCall, Brian; Pierce, Mark; Graviss, Edward A.; Richards-Kortum, Rebecca R.; Tkaczyk, Tomasz S.

2016-03-01

A miniature objective designed for digital detection of Mycobacterium tuberculosis (MTB) was evaluated for diagnostic accuracy. The objective was designed for array microscopy, but fabricated and evaluated at this stage of development as a single objective. The counts and diagnoses of patient samples were directly compared for digital detection and standard microscopy. The results were found to be correlated and highly concordant. The evaluation of this lens by direct comparison to standard fluorescence sputum smear microscopy presented unique challenges and led to some new insights in the role played by the system parameters of the microscope. The design parameters and how they were developed are reviewed in light of these results. New system parameters are proposed with the goal of easing the challenges of evaluating the miniature objective and maintaining the optical performance that produced the agreeable results presented without over-optimizing. A new design is presented that meets and exceeds these criteria.

Object-Oriented Design for Sparse Direct Solvers

NASA Technical Reports Server (NTRS)

Dobrian, Florin; Kumfert, Gary; Pothen, Alex

1999-01-01

We discuss the object-oriented design of a software package for solving sparse, symmetric systems of equations (positive definite and indefinite) by direct methods. At the highest layers, we decouple data structure classes from algorithmic classes for flexibility. We describe the important structural and algorithmic classes in our design, and discuss the trade-offs we made for high performance. The kernels at the lower layers were optimized by hand. Our results show no performance loss from our object-oriented design, while providing flexibility, case of use, and extensibility over solvers using procedural design.

Application of Probabilistic Methods for the Determination of an Economically Robust HSCT Configuration

NASA Technical Reports Server (NTRS)

Mavris, Dimitri N.; Bandte, Oliver; Schrage, Daniel P.

1996-01-01

This paper outlines an approach for the determination of economically viable robust design solutions using the High Speed Civil Transport (HSCT) as a case study. Furthermore, the paper states the advantages of a probability based aircraft design over the traditional point design approach. It also proposes a new methodology called Robust Design Simulation (RDS) which treats customer satisfaction as the ultimate design objective. RDS is based on a probabilistic approach to aerospace systems design, which views the chosen objective as a distribution function introduced by so called noise or uncertainty variables. Since the designer has no control over these variables, a variability distribution is defined for each one of them. The cumulative effect of all these distributions causes the overall variability of the objective function. For cases where the selected objective function depends heavily on these noise variables, it may be desirable to obtain a design solution that minimizes this dependence. The paper outlines a step by step approach on how to achieve such a solution for the HSCT case study and introduces an evaluation criterion which guarantees the highest customer satisfaction. This customer satisfaction is expressed by the probability of achieving objective function values less than a desired target value.

The Author’s Guide to Writing Air Force Flight Test Center Technical Reports

DTIC Science & Technology

2009-08-01

or designated technical expert 2. Author(s): you and anyone also listed as an author 3. Author’s lead at the test organization 4. An operator...it was designed to do, not what it actually did (it should not sound like results). 4. Objectives: State the general objective(s). Do not list the...met or could not meet design objectives and whether or not it was cleared for operational release, as applicable. Do not provide recommendations

Optical design concept for the Giant Magellan Telescope Multi-object Astronomical and Cosmological Spectrograph (GMACS)

NASA Astrophysics Data System (ADS)

Schmidt, Luke M.; Ribeiro, Rafael; Taylor, Keith; Jones, Damien; Prochaska, Travis; DePoy, Darren L.; Marshall, Jennifer L.; Cook, Erika; Froning, Cynthia; Ji, Tae-Geun; Lee, Hye-In; Mendes de Oliveira, Claudia; Pak, Soojong; Papovich, Casey

2016-08-01

We present a preliminary conceptual optical design for GMACS, a wide field, multi-object, optical spectrograph currently being developed for the Giant Magellan Telescope (GMT). We include details of the optical design requirements derived from the instrument scientific and technical objectives and demonstrate how these requirements are met by the current design. Detector specifications, field acquisition/alignment optics, and optical considerations for the active flexure control system are also discussed.

Design optimization of axial flow hydraulic turbine runner: Part II - multi-objective constrained optimization method

NASA Astrophysics Data System (ADS)

Peng, Guoyi; Cao, Shuliang; Ishizuka, Masaru; Hayama, Shinji

2002-06-01

This paper is concerned with the design optimization of axial flow hydraulic turbine runner blade geometry. In order to obtain a better design plan with good performance, a new comprehensive performance optimization procedure has been presented by combining a multi-variable multi-objective constrained optimization model with a Q3D inverse computation and a performance prediction procedure. With careful analysis of the inverse design of axial hydraulic turbine runner, the total hydraulic loss and the cavitation coefficient are taken as optimization objectives and a comprehensive objective function is defined using the weight factors. Parameters of a newly proposed blade bound circulation distribution function and parameters describing positions of blade leading and training edges in the meridional flow passage are taken as optimization variables.The optimization procedure has been applied to the design optimization of a Kaplan runner with specific speed of 440 kW. Numerical results show that the performance of designed runner is successfully improved through optimization computation. The optimization model is found to be validated and it has the feature of good convergence. With the multi-objective optimization model, it is possible to control the performance of designed runner by adjusting the value of weight factors defining the comprehensive objective function. Copyright

Multiparadigm Design Environments

DTIC Science & Technology

1992-01-01

following results: 1. New methods for programming in terms of conceptual models 2. Design of object-oriented languages 3. Compiler optimization and...experimented with object-based methods for programming directly in terms of conceptual models, object-oriented language design, computer program...expect the3e results to have a strong influence on future ,,j :- ...... L ! . . • a mm ammmml ll Illlll • l I 1 Conceptual Programming Conceptual

MODeLeR: A Virtual Constructivist Learning Environment and Methodology for Object-Oriented Design

ERIC Educational Resources Information Center

Coffey, John W.; Koonce, Robert

2008-01-01

This article contains a description of the organization and method of use of an active learning environment named MODeLeR, (Multimedia Object Design Learning Resource), a tool designed to facilitate the learning of concepts pertaining to object modeling with the Unified Modeling Language (UML). MODeLeR was created to provide an authentic,…

Global, Multi-Objective Trajectory Optimization With Parametric Spreading

NASA Technical Reports Server (NTRS)

Vavrina, Matthew A.; Englander, Jacob A.; Phillips, Sean M.; Hughes, Kyle M.

2017-01-01

Mission design problems are often characterized by multiple, competing trajectory optimization objectives. Recent multi-objective trajectory optimization formulations enable generation of globally-optimal, Pareto solutions via a multi-objective genetic algorithm. A byproduct of these formulations is that clustering in design space can occur in evolving the population towards the Pareto front. This clustering can be a drawback, however, if parametric evaluations of design variables are desired. This effort addresses clustering by incorporating operators that encourage a uniform spread over specified design variables while maintaining Pareto front representation. The algorithm is demonstrated on a Neptune orbiter mission, and enhanced multidimensional visualization strategies are presented.

Object-Oriented Control System Design Using On-Line Training of Artificial Neural Networks

NASA Technical Reports Server (NTRS)

Rubaai, Ahmed

1997-01-01

This report deals with the object-oriented model development of a neuro-controller design for permanent magnet (PM) dc motor drives. The system under study is described as a collection of interacting objects. Each object module describes the object behaviors, called methods. The characteristics of the object are included in its variables. The knowledge of the object exists within its variables, and the performance is determined by its methods. This structure maps well to the real world objects that comprise the system being modeled. A dynamic learning architecture that possesses the capabilities of simultaneous on-line identification and control is incorporated to enforce constraints on connections and control the dynamics of the motor. The control action is implemented "on-line", in "real time" in such a way that the predicted trajectory follows a specified reference model. A design example of controlling a PM dc motor drive on-line shows the effectiveness of the design tool. This will therefore be very useful in aerospace applications. It is expected to provide an innovative and noval software model for the rocket engine numerical simulator executive.

Systematic procedure for designing processes with multiple environmental objectives.

PubMed

Kim, Ki-Joo; Smith, Raymond L

2005-04-01

Evaluation of multiple objectives is very important in designing environmentally benign processes. It requires a systematic procedure for solving multiobjective decision-making problems due to the complex nature of the problems, the need for complex assessments, and the complicated analysis of multidimensional results. In this paper, a novel systematic procedure is presented for designing processes with multiple environmental objectives. This procedure has four steps: initialization, screening, evaluation, and visualization. The first two steps are used for systematic problem formulation based on mass and energy estimation and order of magnitude analysis. In the third step, an efficient parallel multiobjective steady-state genetic algorithm is applied to design environmentally benign and economically viable processes and to provide more accurate and uniform Pareto optimal solutions. In the last step a new visualization technique for illustrating multiple objectives and their design parameters on the same diagram is developed. Through these integrated steps the decision-maker can easily determine design alternatives with respect to his or her preferences. Most importantly, this technique is independent of the number of objectives and design parameters. As a case study, acetic acid recovery from aqueous waste mixtures is investigated by minimizing eight potential environmental impacts and maximizing total profit. After applying the systematic procedure, the most preferred design alternatives and their design parameters are easily identified.

Resilience-based optimal design of water distribution network

NASA Astrophysics Data System (ADS)

Suribabu, C. R.

2017-11-01

Optimal design of water distribution network is generally aimed to minimize the capital cost of the investments on tanks, pipes, pumps, and other appurtenances. Minimizing the cost of pipes is usually considered as a prime objective as its proportion in capital cost of the water distribution system project is very high. However, minimizing the capital cost of the pipeline alone may result in economical network configuration, but it may not be a promising solution in terms of resilience point of view. Resilience of the water distribution network has been considered as one of the popular surrogate measures to address ability of network to withstand failure scenarios. To improve the resiliency of the network, the pipe network optimization can be performed with two objectives, namely minimizing the capital cost as first objective and maximizing resilience measure of the configuration as secondary objective. In the present work, these two objectives are combined as single objective and optimization problem is solved by differential evolution technique. The paper illustrates the procedure for normalizing the objective functions having distinct metrics. Two of the existing resilience indices and power efficiency are considered for optimal design of water distribution network. The proposed normalized objective function is found to be efficient under weighted method of handling multi-objective water distribution design problem. The numerical results of the design indicate the importance of sizing pipe telescopically along shortest path of flow to have enhanced resiliency indices.

Layered Learning Design: Towards an Integration of Learning Design and Learning Object Perspectives

ERIC Educational Resources Information Center

Boyle, Tom

2010-01-01

The use of ICT to enhance teaching and learning depends on effective design, which operates at many levels of granularity from the small to the very large. This reflects the range of educational problems from course design down to the design of activities focused on specific learning objectives. For maximum impact these layers of design need to be…

Object Design: Twelve Concepts to Know, Understand and Apply

ERIC Educational Resources Information Center

Marschalek, Douglas G.

2005-01-01

Some art teachers say that art is all around us when they actually mean that "design" is all around us. The everyday objects we view, purchase, and use are designed. Some are well designed, others are poorly designed, and many are in-between. Teachers need to develop learning strategies that enable their students to understand how design is part…

Genetic algorithm approaches for conceptual design of spacecraft systems including multi-objective optimization and design under uncertainty

NASA Astrophysics Data System (ADS)

Hassan, Rania A.

In the design of complex large-scale spacecraft systems that involve a large number of components and subsystems, many specialized state-of-the-art design tools are employed to optimize the performance of various subsystems. However, there is no structured system-level concept-architecting process. Currently, spacecraft design is heavily based on the heritage of the industry. Old spacecraft designs are modified to adapt to new mission requirements, and feasible solutions---rather than optimal ones---are often all that is achieved. During the conceptual phase of the design, the choices available to designers are predominantly discrete variables describing major subsystems' technology options and redundancy levels. The complexity of spacecraft configurations makes the number of the system design variables that need to be traded off in an optimization process prohibitive when manual techniques are used. Such a discrete problem is well suited for solution with a Genetic Algorithm, which is a global search technique that performs optimization-like tasks. This research presents a systems engineering framework that places design requirements at the core of the design activities and transforms the design paradigm for spacecraft systems to a top-down approach rather than the current bottom-up approach. To facilitate decision-making in the early phases of the design process, the population-based search nature of the Genetic Algorithm is exploited to provide computationally inexpensive---compared to the state-of-the-practice---tools for both multi-objective design optimization and design optimization under uncertainty. In terms of computational cost, those tools are nearly on the same order of magnitude as that of standard single-objective deterministic Genetic Algorithm. The use of a multi-objective design approach provides system designers with a clear tradeoff optimization surface that allows them to understand the effect of their decisions on all the design objectives under consideration simultaneously. Incorporating uncertainties avoids large safety margins and unnecessary high redundancy levels. The focus on low computational cost for the optimization tools stems from the objective that improving the design of complex systems should not be achieved at the expense of a costly design methodology.

Integrating end-to-end threads of control into object-oriented analysis and design

NASA Technical Reports Server (NTRS)

Mccandlish, Janet E.; Macdonald, James R.; Graves, Sara J.

1993-01-01

Current object-oriented analysis and design methodologies fall short in their use of mechanisms for identifying threads of control for the system being developed. The scenarios which typically describe a system are more global than looking at the individual objects and representing their behavior. Unlike conventional methodologies that use data flow and process-dependency diagrams, object-oriented methodologies do not provide a model for representing these global threads end-to-end. Tracing through threads of control is key to ensuring that a system is complete and timing constraints are addressed. The existence of multiple threads of control in a system necessitates a partitioning of the system into processes. This paper describes the application and representation of end-to-end threads of control to the object-oriented analysis and design process using object-oriented constructs. The issue of representation is viewed as a grouping problem, that is, how to group classes/objects at a higher level of abstraction so that the system may be viewed as a whole with both classes/objects and their associated dynamic behavior. Existing object-oriented development methodology techniques are extended by adding design-level constructs termed logical composite classes and process composite classes. Logical composite classes are design-level classes which group classes/objects both logically and by thread of control information. Process composite classes further refine the logical composite class groupings by using process partitioning criteria to produce optimum concurrent execution results. The goal of these design-level constructs is to ultimately provide the basis for a mechanism that can support the creation of process composite classes in an automated way. Using an automated mechanism makes it easier to partition a system into concurrently executing elements that can be run in parallel on multiple processors.

A conceptual review of the cultural significance of `Takhtah Table'

NASA Astrophysics Data System (ADS)

Abdo, Fatema M.; Ibrahim, Fuziah

2017-10-01

There exists nowadays a growing awareness about the development of cultural objects. The impact of such development on the identity of nations and global design platforms is significant. Diminishing barriers among societies has helped to spread creative ideas. Recognizing the direction of designs is supposed to develop the lifestyle of nations, cultures, and identities through interior design spaces and their elements such as furniture. The first step to a sustainable creativity goes through an identification stage that upholds the satisfaction of products' users. Through the identification stage, furniture designers encounter some challenges that are mostly related to the cultural significance of an object before starting to develop that object, especially within the context of a different approach. This paper presents the concept of the cultural significance of objects. It also highlights and illustrates the relations between cultural levels and types of meanings that can be reflected by certain objects. This paper provides information guidelines about cultural objects in a form that helps designers continue the development of the nation's creativity. `Takhtah Table' has been presented as a sample of cultural objects, which needs to be maintained in Sana'a City in Yemen.

Design, assembly, and metrology of an oil-immersion microscope objective with long working distance

NASA Astrophysics Data System (ADS)

Peng, Wei-Jei; Lin, Wen-Lung; Kuo, Hui-Jean; Ho, Cheng-Fang; Hsu, Wei-Yao

2016-10-01

The design, tolerance sensitivity reduction, assembly, and optical bench test for an oil-immersion microscope objective with long working distance employed in a lattice light-sheet microscope is presented in this paper. In this application, the orthogonal excitation and detection objectives are dipped in an oil medium. The excitation objective focuses the incident laser beam to generate fluorescence on specimen for collecting by detection objective. The excitation objective is custom-designed to meet the requirement specification such as oil-immersion, the long working distance, and numerical aperture (NA) of 0.5, etc. To produce an acceptable point spread function (PSF) for effective excitation, the performance of the objective needs to be close to diffraction limit. Because the tolerance of the modulation transfer function (MTF) is more and more sensitive at higher spatial frequency, it is extremely critical to keep the performance after manufacture. Consequently, an insensitive optical design is very important for relaxing tolerance. We compare the design with and without tolerance sensitivity reduction, and the as-built MTF shows the result. Furthermore, the method for sensitivity reduction is presented. The opto-mechanical design and assembly method are also discussed. Eventually, the objective with five spherical lenses was fabricated. In optical bench test, the depth of the oil is sensitive to MTF, and it leads to the complicated adjustment. For solving this issue, we made an index-matching lens to replace oil for measurement easily. Finally, the measured MTF of the excitation objective can accomplish the requirement specification and successfully employed in a lattice light-sheet microscope.

Structural Analysis in a Conceptual Design Framework

NASA Technical Reports Server (NTRS)

Padula, Sharon L.; Robinson, Jay H.; Eldred, Lloyd B.

2012-01-01

Supersonic aircraft designers must shape the outer mold line of the aircraft to improve multiple objectives, such as mission performance, cruise efficiency, and sonic-boom signatures. Conceptual designers have demonstrated an ability to assess these objectives for a large number of candidate designs. Other critical objectives and constraints, such as weight, fuel volume, aeroelastic effects, and structural soundness, are more difficult to address during the conceptual design process. The present research adds both static structural analysis and sizing to an existing conceptual design framework. The ultimate goal is to include structural analysis in the multidisciplinary optimization of a supersonic aircraft. Progress towards that goal is discussed and demonstrated.

A randomized, controlled trial of team-based competition to increase learner participation in quality-improvement education.

PubMed

Scales, Charles D; Moin, Tannaz; Fink, Arlene; Berry, Sandra H; Afsar-Manesh, Nasim; Mangione, Carol M; Kerfoot, B Price

2016-04-01

Several barriers challenge resident engagement in learning quality improvement (QI). We investigated whether the incorporation of team-based game mechanics into an evidence-based online learning platform could increase resident participation in a QI curriculum. Randomized, controlled trial. Tertiary-care medical center residency training programs. Resident physicians (n = 422) from nine training programs (anesthesia, emergency medicine, family medicine, internal medicine, ophthalmology, orthopedics, pediatrics, psychiatry and general surgery) randomly allocated to a team competition environment (n = 200) or the control group (n = 222). Specialty-based team assignment with leaderboards to foster competition, and alias assignment to de-identify individual participants. Participation in online learning, as measured by percentage of questions attempted (primary outcome) and additional secondary measures of engagement (i.e. response time). Changes in participation measures over time between groups were assessed with a repeated measures ANOVA framework. Residents in the intervention arm demonstrated greater participation than the control group. The percentage of questions attempted at least once was greater in the competition group (79% [SD ± 32] versus control, 68% [SD ± 37], P= 0.03). Median response time was faster in the competition group (P= 0.006). Differences in participation continued to increase over the duration of the intervention, as measured by average response time and cumulative percent of questions attempted (each P< 0.001). Team competition increases resident participation in an online course delivering QI content. Medical educators should consider game mechanics to optimize participation when designing learning experiences. Published by Oxford University Press in association with the International Society for Quality in Health Care 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Countering the demand for, and supply of, illicit tobacco: an assessment of the 'North of England Tackling Illicit Tobacco for Better Health' Programme.

PubMed

McNeill, Ann; Iringe-Koko, Belinda; Bains, Manpreet; Bauld, Linda; Siggens, Geoffrey; Russell, Andrew

2014-05-01

Illicit tobacco (IT) undermines the effectiveness of tobacco control strategies. We assessed the implementation and impact of a new programme designed to reduce demand for, as well as supply of, IT, in the north of England, where IT was prevalent. 'Mixed methods' research was undertaken. Qualitative methods included stakeholder interviews (at outset and 1 year later) and ethnographic research. Indicators reflecting those supply and demand issues for which data were available were identified and monitored, including relevant items on two cross-sectional surveys carried out in 2009 and 2011 with over 4000 individuals from which a social marketing campaign was also developed. IT reports to two existing hotlines, promoted through the programme, were assessed. Initially, concerns abounded about the different philosophies and ways of working of local and national enforcement and health agencies, but these were much reduced at follow-up. A protocol was developed which greatly facilitated the flow of intelligence about IT supply. A social marketing campaign was developed highlighting two messages: IT makes it easier for children to start smoking and brings crime into the community, thereby avoiding misleading messages about relative harms of illicit and licit tobacco. Public and stakeholder awareness of IT increased as did calls to both hotlines. A partnership of agencies, with competing values, was established to tackle IT, a complex public health issue and, inter alia, implemented a social marketing campaign using novel messages. This improved the flow of intelligence about the supply of IT and increased awareness of IT. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

The Measurement of Gravitomagnetism: A Challenging Enterprise

NASA Astrophysics Data System (ADS)

Iorio, Lorenzo

2007-11-01

This book is intended to give an updated overview on the state-of-the art of the theoretical and experimental efforts aimed to detect the elusive Lense-Thirring effect in the gravitational field of the Earth. The reader, after a robust introduction to the historical (Chapter 2) and theoretical (Chapters 3-5) aspects of the subject, will get acquainted with the subtleties required to design suitable observables which are able to sufficiently enhance the signal-to-noise ratio. Moreover, he/she should be able to follow autonomously the exciting developments which, hopefully, will take place in the near future if and when reliable few percent tests of this prediction of general relativity should become available. In an Earth-space based experiment with artificial satellites a good compromise between the need of reducing the impact of the systematic errors of gravitational origin and of non-gravitational origin must be obtained; this is not an easy task because such requirements are often in conflict one with each other. Consequently, a great attention is paid to elucidate many classical perturbing effects which, if not carefully modelled and accounted for in the data analysis, may alias the recovery of the gravitomagnetic signature. Indeed, we are dealing with a fundamental test of general relativity which must be honest, robust and based on solid error analysis. A critical and detailed discussion of the latest test with the LAGEOS satellites is included. The book will also be useful for better understanding the interplay among various geodetic, geophysical, general relativistic, astronomical and matter-wave interferometric effects which occurs in the weak-field and slow-motion approximation and which will become increasingly important in the near future thanks to the improvements in the accuracy of the orbital reconstruction process.

Countering the demand for, and supply of, illicit tobacco: an assessment of the ‘North of England Tackling Illicit Tobacco for Better Health’ Programme

PubMed Central

McNeill, Ann; Iringe-Koko, Belinda; Bains, Manpreet; Bauld, Linda; Siggens, Geoffrey; Russell, Andrew

2014-01-01

Background Illicit tobacco (IT) undermines the effectiveness of tobacco control strategies. We assessed the implementation and impact of a new programme designed to reduce demand for, as well as supply of, IT, in the north of England, where IT was prevalent. Methods ‘Mixed methods’ research was undertaken. Qualitative methods included stakeholder interviews (at outset and 1 year later) and ethnographic research. Indicators reflecting those supply and demand issues for which data were available were identified and monitored, including relevant items on two cross-sectional surveys carried out in 2009 and 2011 with over 4000 individuals from which a social marketing campaign was also developed. IT reports to two existing hotlines, promoted through the programme, were assessed. Results Initially, concerns abounded about the different philosophies and ways of working of local and national enforcement and health agencies, but these were much reduced at follow-up. A protocol was developed which greatly facilitated the flow of intelligence about IT supply. A social marketing campaign was developed highlighting two messages: IT makes it easier for children to start smoking and brings crime into the community, thereby avoiding misleading messages about relative harms of illicit and licit tobacco. Public and stakeholder awareness of IT increased as did calls to both hotlines. Conclusions A partnership of agencies, with competing values, was established to tackle IT, a complex public health issue and, inter alia, implemented a social marketing campaign using novel messages. This improved the flow of intelligence about the supply of IT and increased awareness of IT. PMID:23958644

"MTA"-an Hydraulic Silicate Cement: review update and setting reaction.

PubMed

Darvell, B W; Wu, R C T

2011-05-01

To review the current status and understanding of Portland cement-like endodontic materials commonly referred to by the trade designation "MTA" (alias "Mineral Trioxide Aggregate"), and to present an outline setting reaction scheme, hitherto unattempted. The literature was searched using on-line tools, overlapping an earlier substantial review to pick up any omissions, including that in respect of ordinary Portland cement (OPC), with which MTA shares much. The search was conducted for the period January 2005 to December 2009 using 'MTA', 'GMTA', 'WMTA', and 'mineral AND trioxide AND aggregate' as keywords, with various on-line search engines including ScienceDirect (http://www.sciencedirect.com), SAGE Journals Online (http://online.sagepub.com), Wiley Online Library (http://onlinelibrary.wiley.com), SciELO Scientific electronic library online (http://www.scielo.br/scielo.php), JSTOR (http://www.jstor.org), and Scopus (http://www.scopus.com). References of articles found were cross-checked where appropriate for missed publications. Manufacturers' and related websites were searched with Google Search (http://www.google.com.hk). A generic name for this class of materials, Hydraulic Silicate Cement (HSC), is proposed, and an outline reaction scheme has been deduced. HSC has distinct advantages apparent, including sealing, sterilizing, mineralizing, dentinogenic and osteogenic capacities, which research continues to demonstrate. However, ad hoc modifications have little supporting justification. While HSC has a definite place in dentistry, with few of the drawbacks associated with other materials, some improvements in handling and other properties are highly desirable, as are studies of the mechanisms of the several beneficial physiological effects. Reference to the extensive, but complex, literature on OPC may provide the necessary insight. Copyright © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Impact of the Jamaican birth cohort study on maternal, child and adolescent health policy and practice.

PubMed

McCaw-Binns, A; Ashley, D; Samms-Vaughan, M

2010-01-01

The Jamaica Perinatal Morbidity and Mortality Survey (JPMMS) was a national study designed to identify modifiable risk factors associated with poor maternal and perinatal outcome. Needing to better understand factors that promote or retard child development, behaviour and academic achievement, we conducted follow-up studies of the birth cohort. The paper describes the policy developments from the JPMMS and two follow-up rounds. The initial study (1986-87) documented 94% of all births and their outcomes on the island over 2 months (n = 10 508), and perinatal (n = 2175) and maternal deaths (n = 62) for a further 10 months. A subset of the birth cohort, identified by their date of birth through school records, was seen at ages 11-12 (n = 1715) and 15-16 years (n = 1563). Findings from the initial survey led to, inter alia, clinic-based screening for syphilis, referral high-risk clinics run by visiting obstetricians, and the redesign and construction of new labour wards at referral hospitals. The follow-up studies documented inadequate academic achievement among boys and children attending public schools, and associations between under- and over-nutrition, excessive television viewing (>20 h/week), inadequate parental supervision and behavioural problems. These contributed to the development of a television programming code for children, a National Parenting Policy, policies aimed at improving inter-sectoral services to children from birth to 5 years (Early Childhood Commission) and behavioural interventions of the Violence Prevention Alliance (an inter-sectoral NGO) and the Healthy Lifestyles project (Ministry of Health). Indigenous maternal and child health research provided a local evidence base that informed public policy. Collaboration, good communication, being vigilant to opportunities to influence policy, and patience has contributed to our success.

Object Toolkit Version 4.3 User’s Manual

DTIC Science & Technology

2016-12-31

unlimited. (OPS-17-12855 dtd 19 Jan 2017) 13. SUPPLEMENTARY NOTES 14. ABSTRACT Object Toolkit is a finite - element model builder specifically designed for...INTRODUCTION 1 What Is Object Toolkit? Object Toolkit is a finite - element model builder specifically designed for creating representations of spacecraft...Nascap-2k and EPIC, the user is not required to purchase or learn expensive finite element generators to create system models. Second, Object Toolkit

Choices, Frameworks and Refinement

NASA Technical Reports Server (NTRS)

Campbell, Roy H.; Islam, Nayeem; Johnson, Ralph; Kougiouris, Panos; Madany, Peter

1991-01-01

In this paper we present a method for designing operating systems using object-oriented frameworks. A framework can be refined into subframeworks. Constraints specify the interactions between the subframeworks. We describe how we used object-oriented frameworks to design Choices, an object-oriented operating system.

Team Based Engineering Design Thinking

ERIC Educational Resources Information Center

Mentzer, Nathan

2012-01-01

The objective of this research was to explore design thinking among teams of high school students. This objective is encompassed in the research question driving this inquiry: How do teams of high school students allocate time across stages of design? Design thinking on the professional level typically occurs in a team environment. Many…

Team Based Engineering Design Thinking

ERIC Educational Resources Information Center

Mentzer, Nathan

2014-01-01

The objective of this research was to explore design thinking among teams of high school students. This objective was encompassed in the research question driving the inquiry: How do teams of high school students allocate time across stages of design? Design thinking on the professional level typically occurs in a team environment. Many…

Optimized Reduction of Unsteady Radial Forces in a Singlechannel Pump for Wastewater Treatment

NASA Astrophysics Data System (ADS)

Kim, Jin-Hyuk; Cho, Bo-Min; Choi, Young-Seok; Lee, Kyoung-Yong; Peck, Jong-Hyeon; Kim, Seon-Chang

2016-11-01

A single-channel pump for wastewater treatment was optimized to reduce unsteady radial force sources caused by impeller-volute interactions. The steady and unsteady Reynolds- averaged Navier-Stokes equations using the shear-stress transport turbulence model were discretized by finite volume approximations and solved on tetrahedral grids to analyze the flow in the single-channel pump. The sweep area of radial force during one revolution and the distance of the sweep-area center of mass from the origin were selected as the objective functions; the two design variables were related to the internal flow cross-sectional area of the volute. These objective functions were integrated into one objective function by applying the weighting factor for optimization. Latin hypercube sampling was employed to generate twelve design points within the design space. A response-surface approximation model was constructed as a surrogate model for the objectives, based on the objective function values at the generated design points. The optimized results showed considerable reduction in the unsteady radial force sources in the optimum design, relative to those of the reference design.

Towards Enhanced Affective Design: Rethinking the Notion of Design

NASA Astrophysics Data System (ADS)

Kim, SuKyoung; Cho, Youngil

2017-09-01

Design disciplines have been contributing to shaping the life of human beings, as well as fostering culture and heritage. Design disciplines and research have been rapidly transforming, and not only objects but also services are target of design. This paper reviews design disciplines towards enhanced affective design, which attributes to intuitive knowledge. It aims at rethinking the notion of design to propose a conceptual framework for integrating user experience into objects that strengthen the form and function based design with pleasing.

Advanced Computing Technologies for Rocket Engine Propulsion Systems: Object-Oriented Design with C++

NASA Technical Reports Server (NTRS)

Bekele, Gete

2002-01-01

This document explores the use of advanced computer technologies with an emphasis on object-oriented design to be applied in the development of software for a rocket engine to improve vehicle safety and reliability. The primary focus is on phase one of this project, the smart start sequence module. The objectives are: 1) To use current sound software engineering practices, object-orientation; 2) To improve on software development time, maintenance, execution and management; 3) To provide an alternate design choice for control, implementation, and performance.

Multi-objective Optimization Design of Gear Reducer Based on Adaptive Genetic Algorithms

NASA Astrophysics Data System (ADS)

Li, Rui; Chang, Tian; Wang, Jianwei; Wei, Xiaopeng; Wang, Jinming

2008-11-01

An adaptive Genetic Algorithm (GA) is introduced to solve the multi-objective optimized design of the reducer. Firstly, according to the structure, strength, etc. in a reducer, a multi-objective optimized model of the helical gear reducer is established. And then an adaptive GA based on a fuzzy controller is introduced, aiming at the characteristics of multi-objective, multi-parameter, multi-constraint conditions. Finally, a numerical example is illustrated to show the advantages of this approach and the effectiveness of an adaptive genetic algorithm used in optimized design of a reducer.

Bilevel formulation of a policy design problem considering multiple objectives and incomplete preferences

NASA Astrophysics Data System (ADS)

Hawthorne, Bryant; Panchal, Jitesh H.

2014-07-01

A bilevel optimization formulation of policy design problems considering multiple objectives and incomplete preferences of the stakeholders is presented. The formulation is presented for Feed-in-Tariff (FIT) policy design for decentralized energy infrastructure. The upper-level problem is the policy designer's problem and the lower-level problem is a Nash equilibrium problem resulting from market interactions. The policy designer has two objectives: maximizing the quantity of energy generated and minimizing policy cost. The stakeholders decide on quantities while maximizing net present value and minimizing capital investment. The Nash equilibrium problem in the presence of incomplete preferences is formulated as a stochastic linear complementarity problem and solved using expected value formulation, expected residual minimization formulation, and the Monte Carlo technique. The primary contributions in this article are the mathematical formulation of the FIT policy, the extension of computational policy design problems to multiple objectives, and the consideration of incomplete preferences of stakeholders for policy design problems.

A SYSTEMATIC PROCEDURE FOR DESIGNING PROCESSES WITH MULTIPLE ENVIRONMENTAL OBJECTIVES

EPA Science Inventory

Evaluation and analysis of multiple objectives are very important in designing environmentally benign processes. They require a systematic procedure for solving multi-objective decision-making problems due to the complex nature of the problems and the need for complex assessment....

Robust design of multiple trailing edge flaps for helicopter vibration reduction: A multi-objective bat algorithm approach

NASA Astrophysics Data System (ADS)

Mallick, Rajnish; Ganguli, Ranjan; Seetharama Bhat, M.

2015-09-01

The objective of this study is to determine an optimal trailing edge flap configuration and flap location to achieve minimum hub vibration levels and flap actuation power simultaneously. An aeroelastic analysis of a soft in-plane four-bladed rotor is performed in conjunction with optimal control. A second-order polynomial response surface based on an orthogonal array (OA) with 3-level design describes both the objectives adequately. Two new orthogonal arrays called MGB2P-OA and MGB4P-OA are proposed to generate nonlinear response surfaces with all interaction terms for two and four parameters, respectively. A multi-objective bat algorithm (MOBA) approach is used to obtain the optimal design point for the mutually conflicting objectives. MOBA is a recently developed nature-inspired metaheuristic optimization algorithm that is based on the echolocation behaviour of bats. It is found that MOBA inspired Pareto optimal trailing edge flap design reduces vibration levels by 73% and flap actuation power by 27% in comparison with the baseline design.

Object-oriented design and programming in medical decision support.

PubMed

Heathfield, H; Armstrong, J; Kirkham, N

1991-12-01

The concept of object-oriented design and programming has recently received a great deal of attention from the software engineering community. This paper highlights the realisable benefits of using the object-oriented approach in the design and development of clinical decision support systems. These systems seek to build a computational model of some problem domain and therefore tend to be exploratory in nature. Conventional procedural design techniques do not support either the process of model building or rapid prototyping. The central concepts of the object-oriented paradigm are introduced, namely encapsulation, inheritance and polymorphism, and their use illustrated in a case study, taken from the domain of breast histopathology. In particular, the dual roles of inheritance in object-oriented programming are examined, i.e., inheritance as a conceptual modelling tool and inheritance as a code reuse mechanism. It is argued that the use of the former is not entirely intuitive and may be difficult to incorporate into the design process. However, inheritance as a means of optimising code reuse offers substantial technical benefits.

Design and fabrication of a miniature objective consisting of high refractive index zinc sulfide lenses for laser surgery

PubMed Central

Shadfan, Adam; Pawlowski, Michal; Wang, Ye; Subramanian, Kaushik; Gabay, Ilan; Ben-Yakar, Adela; Tkaczyk, Tomasz

2016-01-01

A miniature laser ablation probe relying on an optical fiber to deliver light requires a high coupling efficiency objective with sufficient magnification in order to provide adequate power and field for surgery. A diffraction-limited optical design is presented that utilizes high refractive index zinc sulfide to meet specifications while reducing the miniature objective down to two lenses. The design has a hypercentric conjugate plane on the fiber side and is telecentric on the tissue end. Two versions of the objective were built on a diamond lathe—a traditional cylindrical design and a custom-tapered mount. Both received an antireflective coating. The objectives performed as designed in terms of observable resolution and field of view as measured by imaging a 1951 USAF resolution target. The slanted edge technique was used to find Strehl ratios of 0.75 and 0.78, respectively, indicating nearly diffraction-limited performance. Finally, preliminary ablation experiments indicated threshold fluence of gold film was comparable to similar reported probes. PMID:28579656

Design and fabrication of a miniature objective consisting of high refractive index zinc sulfide lenses for laser surgery

NASA Astrophysics Data System (ADS)

Shadfan, Adam; Pawlowski, Michal; Wang, Ye; Subramanian, Kaushik; Gabay, Ilan; Ben-Yakar, Adela; Tkaczyk, Tomasz

2016-02-01

A miniature laser ablation probe relying on an optical fiber to deliver light requires a high coupling efficiency objective with sufficient magnification in order to provide adequate power and field for surgery. A diffraction-limited optical design is presented that utilizes high refractive index zinc sulfide to meet specifications while reducing the miniature objective down to two lenses. The design has a hypercentric conjugate plane on the fiber side and is telecentric on the tissue end. Two versions of the objective were built on a diamond lathe-a traditional cylindrical design and a custom-tapered mount. Both received an antireflective coating. The objectives performed as designed in terms of observable resolution and field of view as measured by imaging a 1951 USAF resolution target. The slanted edge technique was used to find Strehl ratios of 0.75 and 0.78, respectively, indicating nearly diffraction-limited performance. Finally, preliminary ablation experiments indicated threshold fluence of gold film was comparable to similar reported probes.

Structural Optimization of a Force Balance Using a Computational Experiment Design

NASA Technical Reports Server (NTRS)

Parker, P. A.; DeLoach, R.

2002-01-01

This paper proposes a new approach to force balance structural optimization featuring a computational experiment design. Currently, this multi-dimensional design process requires the designer to perform a simplification by executing parameter studies on a small subset of design variables. This one-factor-at-a-time approach varies a single variable while holding all others at a constant level. Consequently, subtle interactions among the design variables, which can be exploited to achieve the design objectives, are undetected. The proposed method combines Modern Design of Experiments techniques to direct the exploration of the multi-dimensional design space, and a finite element analysis code to generate the experimental data. To efficiently search for an optimum combination of design variables and minimize the computational resources, a sequential design strategy was employed. Experimental results from the optimization of a non-traditional force balance measurement section are presented. An approach to overcome the unique problems associated with the simultaneous optimization of multiple response criteria is described. A quantitative single-point design procedure that reflects the designer's subjective impression of the relative importance of various design objectives, and a graphical multi-response optimization procedure that provides further insights into available tradeoffs among competing design objectives are illustrated. The proposed method enhances the intuition and experience of the designer by providing new perspectives on the relationships between the design variables and the competing design objectives providing a systematic foundation for advancements in structural design.

Ecologically and economically conscious design of the injected pultrusion process via multi-objective optimization

NASA Astrophysics Data System (ADS)

Srinivasagupta, Deepak; Kardos, John L.

2004-05-01

Injected pultrusion (IP) is an environmentally benign continuous process for low-cost manufacture of prismatic polymer composites. IP has been of recent regulatory interest as an option to achieve significant vapour emissions reduction. This work describes the design of the IP process with multiple design objectives. In our previous work (Srinivasagupta D et al 2003 J. Compos. Mater. at press), an algorithm for economic design using a validated three-dimensional physical model of the IP process was developed, subject to controllability considerations. In this work, this algorithm was used in a multi-objective optimization approach to simultaneously meet economic, quality related, and environmental objectives. The retrofit design of a bench-scale set-up was considered, and the concept of exergy loss in the process, as well as in vapour emission, was introduced. The multi-objective approach was able to determine the optimal values of the processing parameters such as heating zone temperatures and resin injection pressure, as well as the equipment specifications (die dimensions, heater, puller and pump ratings) that satisfy the various objectives in a weighted sense, and result in enhanced throughput rates. The economic objective did not coincide with the environmental objective, and a compromise became necessary. It was seen that most of the exergy loss is in the conversion of electric power into process heating. Vapour exergy loss was observed to be negligible for the most part.

Multi objective decision making in hybrid energy system design

NASA Astrophysics Data System (ADS)

Merino, Gabriel Guillermo

The design of grid-connected photovoltaic wind generator system supplying a farmstead in Nebraska has been undertaken in this dissertation. The design process took into account competing criteria that motivate the use of different sources of energy for electric generation. The criteria considered were 'Financial', 'Environmental', and 'User/System compatibility'. A distance based multi-objective decision making methodology was developed to rank design alternatives. The method is based upon a precedence order imposed upon the design objectives and a distance metric describing the performance of each alternative. This methodology advances previous work by combining ambiguous information about the alternatives with a decision-maker imposed precedence order in the objectives. Design alternatives, defined by the photovoltaic array and wind generator installed capacities, were analyzed using the multi-objective decision making approach. The performance of the design alternatives was determined by simulating the system using hourly data for an electric load for a farmstead and hourly averages of solar irradiation, temperature and wind speed from eight wind-solar energy monitoring sites in Nebraska. The spatial variability of the solar energy resource within the region was assessed by determining semivariogram models to krige hourly and daily solar radiation data. No significant difference was found in the predicted performance of the system when using kriged solar radiation data, with the models generated vs. using actual data. The spatial variability of the combined wind and solar energy resources was included in the design analysis by using fuzzy numbers and arithmetic. The best alternative was dependent upon the precedence order assumed for the main criteria. Alternatives with no PV array or wind generator dominated when the 'Financial' criteria preceded the others. In contrast, alternatives with a nil component of PV array but a high wind generator component, dominated when the 'Environment' objective or the 'User/System compatibility' objectives were more important than the 'Financial' objectives and they also dominated when the three criteria were considered equally important.

Learn from the Core--Design from the Core

ERIC Educational Resources Information Center

Ockerse, Thomas

2012-01-01

The current objective, object-oriented approach to design is questioned along with design education viewed as a job-oriented endeavor. Instead relational knowledge and experience in a holistic sense, both tacit and explicit, are valued along with an appreciation of the unique character of the student. A new paradigm for design education is…

Scalability of surrogate-assisted multi-objective optimization of antenna structures exploiting variable-fidelity electromagnetic simulation models

NASA Astrophysics Data System (ADS)

Koziel, Slawomir; Bekasiewicz, Adrian

2016-10-01

Multi-objective optimization of antenna structures is a challenging task owing to the high computational cost of evaluating the design objectives as well as the large number of adjustable parameters. Design speed-up can be achieved by means of surrogate-based optimization techniques. In particular, a combination of variable-fidelity electromagnetic (EM) simulations, design space reduction techniques, response surface approximation models and design refinement methods permits identification of the Pareto-optimal set of designs within a reasonable timeframe. Here, a study concerning the scalability of surrogate-assisted multi-objective antenna design is carried out based on a set of benchmark problems, with the dimensionality of the design space ranging from six to 24 and a CPU cost of the EM antenna model from 10 to 20 min per simulation. Numerical results indicate that the computational overhead of the design process increases more or less quadratically with the number of adjustable geometric parameters of the antenna structure at hand, which is a promising result from the point of view of handling even more complex problems.

Object Oriented Modeling and Design

NASA Technical Reports Server (NTRS)

Shaykhian, Gholam Ali

2007-01-01

The Object Oriented Modeling and Design seminar is intended for software professionals and students, it covers the concepts and a language-independent graphical notation that can be used to analyze problem requirements, and design a solution to the problem. The seminar discusses the three kinds of object-oriented models class, state, and interaction. The class model represents the static structure of a system, the state model describes the aspects of a system that change over time as well as control behavior and the interaction model describes how objects collaborate to achieve overall results. Existing knowledge of object oriented programming may benefit the learning of modeling and good design. Specific expectations are: Create a class model, Read, recognize, and describe a class model, Describe association and link, Show abstract classes used with multiple inheritance, Explain metadata, reification and constraints, Group classes into a package, Read, recognize, and describe a state model, Explain states and transitions, Read, recognize, and describe interaction model, Explain Use cases and use case relationships, Show concurrency in activity diagram, Object interactions in sequence diagram.

Multiobjective optimization techniques for structural design

NASA Technical Reports Server (NTRS)

Rao, S. S.

1984-01-01

The multiobjective programming techniques are important in the design of complex structural systems whose quality depends generally on a number of different and often conflicting objective functions which cannot be combined into a single design objective. The applicability of multiobjective optimization techniques is studied with reference to simple design problems. Specifically, the parameter optimization of a cantilever beam with a tip mass and a three-degree-of-freedom vabration isolation system and the trajectory optimization of a cantilever beam are considered. The solutions of these multicriteria design problems are attempted by using global criterion, utility function, game theory, goal programming, goal attainment, bounded objective function, and lexicographic methods. It has been observed that the game theory approach required the maximum computational effort, but it yielded better optimum solutions with proper balance of the various objective functions in all the cases.

A telepresence robot system realized by embedded object concept

NASA Astrophysics Data System (ADS)

Vallius, Tero; Röning, Juha

2006-10-01

This paper presents the Embedded Object Concept (EOC) and a telepresence robot system which is a test case for the EOC. The EOC utilizes common object-oriented methods used in software by applying them to combined Lego-like software-hardware entities. These entities represent objects in object-oriented design methods, and they are the building blocks of embedded systems. The goal of the EOC is to make the designing embedded systems faster and easier. This concept enables people without comprehensive knowledge in electronics design to create new embedded systems, and for experts it shortens the design time of new embedded systems. We present the current status of a telepresence robot created with second-generation Atomi-objects, which is the name for our implementation of the embedded objects. The telepresence robot is a relatively complex test case for the EOC. The robot has been constructed using incremental device development, which is made possible by the architecture of the EOC. The robot contains video and audio exchange capability and a controlling system for driving with two wheels. The robot is built in two versions, the first consisting of a PC device and Atomi-objects, and the second consisting of only Atomi-objects. The robot is currently incomplete, but most of it has been successfully tested.

Automated solar collector installation design

DOEpatents

Wayne, Gary; Frumkin, Alexander; Zaydman, Michael; Lehman, Scott; Brenner, Jules

2014-08-26

Embodiments may include systems and methods to create and edit a representation of a worksite, to create various data objects, to classify such objects as various types of pre-defined "features" with attendant properties and layout constraints. As part of or in addition to classification, an embodiment may include systems and methods to create, associate, and edit intrinsic and extrinsic properties to these objects. A design engine may apply of design rules to the features described above to generate one or more solar collectors installation design alternatives, including generation of on-screen and/or paper representations of the physical layout or arrangement of the one or more design alternatives.

Multiobjective sampling design for parameter estimation and model discrimination in groundwater solute transport

USGS Publications Warehouse

Knopman, Debra S.; Voss, Clifford I.

1989-01-01

Sampling design for site characterization studies of solute transport in porous media is formulated as a multiobjective problem. Optimal design of a sampling network is a sequential process in which the next phase of sampling is designed on the basis of all available physical knowledge of the system. Three objectives are considered: model discrimination, parameter estimation, and cost minimization. For the first two objectives, physically based measures of the value of information obtained from a set of observations are specified. In model discrimination, value of information of an observation point is measured in terms of the difference in solute concentration predicted by hypothesized models of transport. Points of greatest difference in predictions can contribute the most information to the discriminatory power of a sampling design. Sensitivity of solute concentration to a change in a parameter contributes information on the relative variance of a parameter estimate. Inclusion of points in a sampling design with high sensitivities to parameters tends to reduce variance in parameter estimates. Cost minimization accounts for both the capital cost of well installation and the operating costs of collection and analysis of field samples. Sensitivities, discrimination information, and well installation and sampling costs are used to form coefficients in the multiobjective problem in which the decision variables are binary (zero/one), each corresponding to the selection of an observation point in time and space. The solution to the multiobjective problem is a noninferior set of designs. To gain insight into effective design strategies, a one-dimensional solute transport problem is hypothesized. Then, an approximation of the noninferior set is found by enumerating 120 designs and evaluating objective functions for each of the designs. Trade-offs between pairs of objectives are demonstrated among the models. The value of an objective function for a given design is shown to correspond to the ability of a design to actually meet an objective.

A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments.

PubMed

He, Lu; Friedman, Alan M; Bailey-Kellogg, Chris

2012-03-01

In developing improved protein variants by site-directed mutagenesis or recombination, there are often competing objectives that must be considered in designing an experiment (selecting mutations or breakpoints): stability versus novelty, affinity versus specificity, activity versus immunogenicity, and so forth. Pareto optimal experimental designs make the best trade-offs between competing objectives. Such designs are not "dominated"; that is, no other design is better than a Pareto optimal design for one objective without being worse for another objective. Our goal is to produce all the Pareto optimal designs (the Pareto frontier), to characterize the trade-offs and suggest designs most worth considering, but to avoid explicitly considering the large number of dominated designs. To do so, we develop a divide-and-conquer algorithm, Protein Engineering Pareto FRontier (PEPFR), that hierarchically subdivides the objective space, using appropriate dynamic programming or integer programming methods to optimize designs in different regions. This divide-and-conquer approach is efficient in that the number of divisions (and thus calls to the optimizer) is directly proportional to the number of Pareto optimal designs. We demonstrate PEPFR with three protein engineering case studies: site-directed recombination for stability and diversity via dynamic programming, site-directed mutagenesis of interacting proteins for affinity and specificity via integer programming, and site-directed mutagenesis of a therapeutic protein for activity and immunogenicity via integer programming. We show that PEPFR is able to effectively produce all the Pareto optimal designs, discovering many more designs than previous methods. The characterization of the Pareto frontier provides additional insights into the local stability of design choices as well as global trends leading to trade-offs between competing criteria. Copyright © 2011 Wiley Periodicals, Inc.

Understanding visualization: a formal approach using category theory and semiotics.

PubMed

Vickers, Paul; Faith, Joe; Rossiter, Nick

2013-06-01

This paper combines the vocabulary of semiotics and category theory to provide a formal analysis of visualization. It shows how familiar processes of visualization fit the semiotic frameworks of both Saussure and Peirce, and extends these structures using the tools of category theory to provide a general framework for understanding visualization in practice, including: Relationships between systems, data collected from those systems, renderings of those data in the form of representations, the reading of those representations to create visualizations, and the use of those visualizations to create knowledge and understanding of the system under inspection. The resulting framework is validated by demonstrating how familiar information visualization concepts (such as literalness, sensitivity, redundancy, ambiguity, generalizability, and chart junk) arise naturally from it and can be defined formally and precisely. This paper generalizes previous work on the formal characterization of visualization by, inter alia, Ziemkiewicz and Kosara and allows us to formally distinguish properties of the visualization process that previous work does not.

Conformally Invariant Powers of the Laplacian, Q-Curvature, and Tractor Calculus

NASA Astrophysics Data System (ADS)

Gover, A. Rod; Peterson, Lawrence J.

We describe an elementary algorithm for expressing, as explicit formulae in tractor calculus, the conformally invariant GJMS operators due to C.R. Graham et alia. These differential operators have leading part a power of the Laplacian. Conformal tractor calculus is the natural induced bundle calculus associated to the conformal Cartan connection. Applications discussed include standard formulae for these operators in terms of the Levi-Civita connection and its curvature and a direct definition and formula for T. Branson's so-called Q-curvature (which integrates to a global conformal invariant) as well as generalisations of the operators and the Q-curvature. Among examples, the operators of order 4, 6 and 8 and the related Q-curvatures are treated explicitly. The algorithm exploits the ambient metric construction of Fefferman and Graham and includes a procedure for converting the ambient curvature and its covariant derivatives into tractor calculus expressions. This is partly based on [12], where the relationship of the normal standard tractor bundle to the ambient construction is described.

Stopbands in the existence domains of acoustic solitons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nsengiyumva, F., E-mail: franco.nseng@gmail.com; Hellberg, M. A., E-mail: hellberg@ukzn.ac.za; Mace, R. L., E-mail: macer@ukzn.ac.za

2014-10-15

A fully nonlinear Sagdeev pseudopotential approach is used to study the existence domain of fast mode ion-acoustic solitons in a three-species plasma composed of cold and warm adiabatic positive ion species and Boltzmann electrons. It is shown that for appropriate values of the cold-to-warm ion charge-to-mass ratio, μ, and the effective warm ion-to-electron temperature ratio, τ, there is a range in cold to warm ion charge density ratio, f, over which a stopband in soliton speed exists. Solitons do not propagate in the stopband, although they can occur for both higher and lower speeds. The stopbands are associated with amore » limiting curve of the existence domain that is double-valued in speed for a range of values of f. Analytical estimates of the upper and lower limits of τ and μ that support stopbands are found. It is suggested that, inter alia, the analysis should be applicable to the solar wind plasma.« less

Multivalent-Ion-Activated Protein Adsorption Reflecting Bulk Reentrant Behavior.

PubMed

Fries, Madeleine R; Stopper, Daniel; Braun, Michal K; Hinderhofer, Alexander; Zhang, Fajun; Jacobs, Robert M J; Skoda, Maximilian W A; Hansen-Goos, Hendrik; Roth, Roland; Schreiber, Frank

2017-12-01

Protein adsorption at the solid-liquid interface is an important phenomenon that often can be observed as a first step in biological processes. Despite its inherent importance, still relatively little is known about the underlying microscopic mechanisms. Here, using multivalent ions, we demonstrate the control of the interactions and the corresponding adsorption of net-negatively charged proteins (bovine serum albumin) at a solid-liquid interface. This is demonstrated by ellipsometry and corroborated by neutron reflectivity and quartz-crystal microbalance experiments. We show that the reentrant condensation observed within the rich bulk phase behavior of the system featuring a nonmonotonic dependence of the second virial coefficient on salt concentration c_{s} is reflected in an intriguing way in the protein adsorption d(c_{s}) at the interface. Our findings are successfully described and understood by a model of ion-activated patchy interactions within the framework of the classical density functional theory. In addition to the general challenge of connecting bulk and interface behavior, our work has implications for, inter alia, nucleation at interfaces.

Understanding Neuropsychiatric Diseases, Analyzing the Peptide Sharing between Infectious Agents and the Language-Associated NMDA 2A Protein.

PubMed

Lucchese, Guglielmo

2016-01-01

Language disorders and infections may occur together and often concur, to a different extent and via different modalities, in characterizing brain pathologies, such as schizophrenia, autism, epilepsies, bipolar disorders, frontotemporal neurodegeneration, and encephalitis, inter alia. The biological mechanism(s) that might channel language dysfunctions and infections into etiological pathways connected to neuropathologic sequelae are unclear. Searching for molecular link(s) between language disorders and infections, the present study explores the language-associated NMDA 2A subunit for peptide sharing with pathogens that have been described in concomitance with neuropsychiatric diseases. It was found that a vast peptide commonality links the human glutamate ionotropic receptor NMDA 2A subunit to infectious agents. Such a link expands to and interfaces with neuropsychiatric disorders in light of the specific allocation of NMDA 2A gene expression in brain areas related to language functions. The data hint at a possible pathologic scenario based on anti-pathogen immune responses cross-reacting with NMDA 2A in the brain.

Concrete Infrastructure Corrosion

NASA Astrophysics Data System (ADS)

Waanders, F. B.; Vorster, S. W.

2003-06-01

It is well known that many reinforced concrete structures are at risk of deterioration due to chloride ion contamination of the concrete or atmospheric carbon dioxide dissolving in water to form carbonic acid, which reacts with the concrete and the reinforcing steel. The environment within the concrete will determine the corrosion product layers, which might, inter alia, contain the oxides and/or hydroxides of iron. Tensile forces resulting from volume changes during their formation lead to the cracking and delamination of the concrete. In the present investigation the handrail of an outside staircase suffered rebar corrosion during 30 year's service, leading to severe delamination damage to the concrete structure. The railings had been sealed into the concrete staircase using a polysulphide sealant, Thiokol®. The corrosion products were identified by means of Mössbauer and SEM analyses, which indicated that the corrosion product composition varied from the original steel surface to the outer layers, the former being mainly iron oxides and the latter iron oxyhydroxide.

What explains DRG upcoding in neonatology? The roles of financial incentives and infant health.

PubMed

Jürges, Hendrik; Köberlein, Juliane

2015-09-01

We use the introduction of diagnosis related groups (DRGs) in German neonatology to study the determinants of upcoding. Since 2003, reimbursement is based inter alia on birth weight, with substantial discontinuities at eight thresholds. These discontinuities create incentives to upcode preterm infants into classes of lower birth weight. Using data from the German birth statistics 1996-2010 and German hospital data from 2006 to 2011, we show that (1) since the introduction of DRGs, hospitals have upcoded at least 12,000 preterm infants and gained additional reimbursement in excess of 100 million Euro; (2) upcoding rates are systematically higher at thresholds with larger reimbursement hikes and in hospitals that subsequently treat preterm infants, i.e. where the gains accrue; (3) upcoding is systematically linked with newborn health conditional on birth weight. Doctors and midwives respond to financial incentives by not upcoding newborns with low survival probabilities, and by upcoding infants with higher expected treatment costs. Copyright © 2015 Elsevier B.V. All rights reserved.

"Obligated aliens": recognizing sperm donors' ethical obligation to disclose genetic information.

PubMed

Tamir, Sivan

2013-03-01

Sperm donors' obligations are typically constrained to the immediate circumstances surrounding the donation and to its time frame. This paper makes the case for recognizing an ongoing ethical obligation that binds sperm donors to disclose, in a timely manner, meaningful genetic information to recipients and donor-conceived children. The paper delineates and conceptualizes the suggested (potentially reciprocal) duty and argues that it is not the genetic link between the donor and the donor-conceived child that binds donors by said duty, but rather social responsibility. Accordingly, an original perception of the donor as an obligated alien is suggested and developed. The main thesis of the paper is supported inter alia by a comparison between transmitting infectious diseases and passing faulty genes on to donor-conceived children. The paper also provides an in-depth analysis of the conflicting interests of the parties generated by such an obligation and proposes a model for embedding this ethical duty in a (legal) contractual framework.

Philippine protected areas are not meeting the biodiversity coverage and management effectiveness requirements of Aichi Target 11.

PubMed

Mallari, Neil Aldrin D; Collar, Nigel J; McGowan, Philip J K; Marsden, Stuart J

2016-04-01

Aichi Target 11 of the Convention on Biological Diversity urges, inter alia, that nations protect at least 17 % of their land, and that protection is effective and targets areas of importance for biodiversity. Five years before reporting on Aichi targets is due, we assessed the Philippines' current protected area system for biodiversity coverage, appropriateness of management regimes and capacity to deliver protection. Although protected estate already covers 11 % of the Philippines' land area, 64 % of its key biodiversity areas (KBAs) remain unprotected. Few protected areas have appropriate management and governance infrastructures, funding streams, management plans and capacity, and a serious mismatch exists between protected area land zonation regimes and conservation needs of key species. For the Philippines to meet the biodiversity coverage and management effectiveness elements of Aichi Target 11, protected area and KBA boundaries should be aligned, management systems reformed to pursue biodiversity-led targets and effective management capacity created.

Multivalent-Ion-Activated Protein Adsorption Reflecting Bulk Reentrant Behavior

NASA Astrophysics Data System (ADS)

Fries, Madeleine R.; Stopper, Daniel; Braun, Michal K.; Hinderhofer, Alexander; Zhang, Fajun; Jacobs, Robert M. J.; Skoda, Maximilian W. A.; Hansen-Goos, Hendrik; Roth, Roland; Schreiber, Frank

2017-12-01

Protein adsorption at the solid-liquid interface is an important phenomenon that often can be observed as a first step in biological processes. Despite its inherent importance, still relatively little is known about the underlying microscopic mechanisms. Here, using multivalent ions, we demonstrate the control of the interactions and the corresponding adsorption of net-negatively charged proteins (bovine serum albumin) at a solid-liquid interface. This is demonstrated by ellipsometry and corroborated by neutron reflectivity and quartz-crystal microbalance experiments. We show that the reentrant condensation observed within the rich bulk phase behavior of the system featuring a nonmonotonic dependence of the second virial coefficient on salt concentration cs is reflected in an intriguing way in the protein adsorption d (cs) at the interface. Our findings are successfully described and understood by a model of ion-activated patchy interactions within the framework of the classical density functional theory. In addition to the general challenge of connecting bulk and interface behavior, our work has implications for, inter alia, nucleation at interfaces.

Tidal Models In A New Era of Satellite Gravimetry

NASA Technical Reports Server (NTRS)

Ray, Richard D.; Rowlings, David D.; Edbert, G. D.; Chao, Benjamin F. (Technical Monitor)

2002-01-01

The high precision gravity measurements to be made by recently launched (and recently approved) satellites place new demands on models of Earth, atmospheric, and oceanic tides. The latter is the most problematic. The ocean tides induce variations in the Earth's geoid by amounts that far exceed the new satellite sensitivities, and tidal models must be used to correct for this. Two methods are used here to determine the standard errors in current ocean tide models. At long wavelengths these errors exceed the sensitivity of the GRACE mission. Tidal errors will not prevent the new satellite missions from improving our knowledge of the geopotential by orders of magnitude, but the errors may well contaminate GRACE estimates of temporal variations in gravity. Solar tides are especially problematic because of their long alias periods. The satellite data may be used to improve tidal models once a sufficiently long time series is obtained. Improvements in the long-wavelength components of lunar tides are especially promising.

[The microbial flora in the digestive tract and diabetes].

PubMed

Svačina, Štěpán

2015-04-01

The microbial flora in the digestive tract has been recently studied in relation to metabolic diseases. There are relations to both type 1 diabetes and type 2 diabetes. The intestinal flora is affected by diet, physical exercise and it significantly changes after bariatric surgeries. Giving birth by caesarean section affects the gut flora development and increases the risk of type 1 diabetes in further life of the child. Obese patients with type 2 diabetes may lack protective microbes which improve glucoregulation in the experiment or on the contrary their patogenous microbes may grow which have been proven to even be able to penetrate into abdominal adipose tissue and play a role, inter alia, in the hepatic impairment and systemic inflammation. Also vaccination against these microbes is under consideration. Microbiome can be also positively affected by metformin treatment. The transfer of intestinal flora by means of fecal transplantation can improve glucoregulation. The influencing of intestinal flora is likely to become a new mechanism of diabetes treatment.

The dilemma of the symbols: analogies between philosophy, biology and artificial life.

PubMed

Spadaro, Salvatore

2013-01-01

This article analyzes some analogies going from Artificial Life questions about the symbol-matter connection to Artificial Intelligence questions about symbol-grounding. It focuses on the notion of the interpretability of syntax and how the symbols are integrated in a unity ("binding problem"). Utilizing the DNA code as a model, this paper discusses how syntactic features could be defined as high-grade characteristics of the non syntactic relations in a material-dynamic structure, by using an emergentist approach. This topic furnishes the ground for a confutation of J. Searle's statement that syntax is observer-relative, as he wrote in his book "Mind: A Brief Introduction". Moreover the evolving discussion also modifies the classic symbol-processing doctrine in the mind which Searle attacks as a strong AL argument, that life could be implemented in a computational mode. Lastly, this paper furnishes a new way of support for the autonomous systems thesis in Artificial Life and Artificial Intelligence, using, inter alia, the "adaptive resonance theory" (ART).

The Spacing of Strongly Meandering Jets in Quasigeostrophic Turbulence

NASA Astrophysics Data System (ADS)

Scott, R.

2017-12-01

Based on an assumption of inhomogeneous potential vorticity mixing,estimates are obtained for kinetic and potential energies inquasigeostrophic β -plane turbulence with strongly meanderingjets and in the limit of small Rossby deformation length. Theestimates provide, inter alia, a means to predict the jetspacing based on knowledge of either the kinetic or potential energy,which, in situations where the flow is forced with a uniform totalenergy input, are known a priori in the case of frictional orthermal damping, respectively. The estimates are lower bounds for thejet spacing, achieved in the limit of perfect mixing between regularlyspaced jets with simple meanders. These lower bounds are sharp in astrict mathematical sense but are likely to substantiallyunderestimate jet spacing in actual flows, which exhibit a remarkablediversity of structures and irregularities. The latter areillustrated numerically in direct integrations of the forced system.A convenient description of the forced system is presented in terms ofa number of independent length scales of the problem, anddimensionless ratios of these.

Mercury based drug in ancient India: The red sulfide of mercury in nanoscale.

PubMed

Mukhi, Priyabrata; Mohapatra, Swapna Sarita; Bhattacharjee, M; Ray, K K; Muraleedharan, T S; Arun, A; Sathyavathi, R; Juluri, R R; Satyam, P V; Panda, Alok K; Biswas, Ashis; Nayak, S; Bojja, Sreedhar; Pratihar, S; Roy, Sujit

Mercury is one of the elements which had attracted the attention of the chemists and physicians of ancient India and China. Among the various metal based drugs which utilize mercury, we became interested in the red sulfide of mercury which is known in ancient Indian literature as rasasindur (alias rasasindura, rasasindoor, rasasinduram, sindur, or sindoor) and is used extensively in various ailments and diseases. Following various physico-chemical characterizations it is concluded that rasasindur is chemically pure α-HgS with Hg:S ratio as 1:1. Analysis of rasasindur vide Transmission Electron Microscopy (TEM) showed that the particles are in nanoscale. Bio-chemical studies of rasasindur were also demonstrated. It interacts with Bovine Serum Albumin (BSA) with an association constant of (9.76 ± 0.56) × 10 3 M -1 and behaves as a protease inhibitor by inhibiting the proteolysis of BSA by trypsin. It also showed mild antioxidant properties. Copyright © 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Published by Elsevier B.V. All rights reserved.

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery☆

PubMed Central

Kell, Douglas B.; Goodacre, Royston

2014-01-01

Metabolism represents the ‘sharp end’ of systems biology, because changes in metabolite concentrations are necessarily amplified relative to changes in the transcriptome, proteome and enzyme activities, which can be modulated by drugs. To understand such behaviour, we therefore need (and increasingly have) reliable consensus (community) models of the human metabolic network that include the important transporters. Small molecule ‘drug’ transporters are in fact metabolite transporters, because drugs bear structural similarities to metabolites known from the network reconstructions and from measurements of the metabolome. Recon2 represents the present state-of-the-art human metabolic network reconstruction; it can predict inter alia: (i) the effects of inborn errors of metabolism; (ii) which metabolites are exometabolites, and (iii) how metabolism varies between tissues and cellular compartments. However, even these qualitative network models are not yet complete. As our understanding improves so do we recognise more clearly the need for a systems (poly)pharmacology. PMID:23892182

Polyploidization in liver tissue.

PubMed

Gentric, Géraldine; Desdouets, Chantal

2014-02-01

Polyploidy (alias whole genome amplification) refers to organisms containing more than two basic sets of chromosomes. Polyploidy was first observed in plants more than a century ago, and it is known that such processes occur in many eukaryotes under a variety of circumstances. In mammals, the development of polyploid cells can contribute to tissue differentiation and, therefore, possibly a gain of function; alternately, it can be associated with development of disease, such as cancer. Polyploidy can occur because of cell fusion or abnormal cell division (endoreplication, mitotic slippage, or cytokinesis failure). Polyploidy is a common characteristic of the mammalian liver. Polyploidization occurs mainly during liver development, but also in adults with increasing age or because of cellular stress (eg, surgical resection, toxic exposure, or viral infections). This review will explore the mechanisms that lead to the development of polyploid cells, our current state of understanding of how polyploidization is regulated during liver growth, and its consequence on liver function. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Potential and Pitfalls of High-Rate GPS

NASA Astrophysics Data System (ADS)

Smalley, R.

2008-12-01

With completion of the Plate Boundary Observatory (PBO), we are poised to capture a dense sampling of strong motion displacement time series from significant earthquakes in western North America with High-Rate GPS (HRGPS) data collected at 1 and 5 Hz. These data will provide displacement time series at potentially zero epicentral distance that, if valid, have great potential to contribute to understanding earthquake rupture processes. The caveat relates to whether or not the data are aliased: is the sampling rate fast enough to accurately capture the displacement's temporal history? Using strong motion recordings in the immediate epicentral area of several 6.77.5 events, which can be reasonably expected in the PBO footprint, even the 5 Hz data may be aliased. Some sort of anti-alias processing, currently not applied, will therefore necessary at the closest stations to guarantee the veracity of the displacement time series. We discuss several solutions based on a-priori knowledge of the expected ground motion and practicality of implementation.

[Quality assurance of rehabilitation by the German pension insurance: an overview].

PubMed

Klosterhuis, H; Baumgarten, E; Beckmann, U; Erbstösser, S; Lindow, B; Naumann, B; Widera, T; Zander, J

2010-12-01

The German pension insurance has in recent years developed a comprehensive programme for quality assurance in rehabilitation, and has implemented the programme into routine practice. Different aspects of rehabilitation are evaluated with differentiated instruments. Issues dealt with inter alia include the quality of rehabilitative care in a narrower sense, the structure and organisation of the rehabilitation centres, as well as quality from the patients' perspective. On the whole, positive results predominate. Big differences in quality however have been found between the rehabilitation centres. The data collections and data evaluations carried out make a continuous process of quality assurance reporting possible for use by rehabilitation centres and pension insurance agencies. This will enable targeted initiatives for quality improvement. The methods and procedures of quality assurance are enhanced at regular intervals, and the scope of quality assurance is extended. Thus, rehab quality assurance is also expanded to cover ambulant rehabilitation or rehabilitation of children and young people. © Georg Thieme Verlag KG Stuttgart · New York.

Utah FORGE Gravity Data Shapefile

DOE Data Explorer

Joe Moore

2016-03-13

This is a zipped GIS compatible shapefile of gravity data points used in the Milford, Utah FORGE project as of March 21st, 2016. The shapefile is native to ArcGIS, but can be used with many GIS software packages. Additionally, there is a .dbf (dBase) file that contains the dataset which can be read with Microsoft Excel. The Data was downloaded from the PACES (Pan American Center for Earth and Environmental Studies) hosted by University of Texas El Paso (http://research.utep.edu/Default.aspx?alias=research.utep.edu/paces) Explanation:Source: data source code if available LatNAD83: latitude in NAD83 [decimal degrees] LonNAD83: longitude in NAD83 [decimal degrees]zWGS84: elevation in WGS84 (ellipsoidal) [m]OBSless976: observed gravity minus 976000 mGalIZTC: inner zone terrain correction [mGal]OZTC: outer zone terrain correction [mGal]FA: Free Air anomaly value [mGal]CBGA: Complete Bouguer gravity anomaly value [mGal

A Comparison of Carbon Footprint and Production Cost of Different Pasta Products Based on Whole Egg and Pea Flour

PubMed Central

Nette, Antonia; Wolf, Patricia; Schlüter, Oliver; Meyer-Aurich, Andreas

2016-01-01

Feed and food production are inter alia reasons for high greenhouse gas emissions. Greenhouse gas emissions could be reduced by the replacement of animal components with plant components in processed food products, such as pasta. The main components currently used for pasta are semolina, and water, as well as additional egg. The hypothesis of this paper is that the substitution of whole egg with plant-based ingredients, for example from peas, in such a product might lead to reduced greenhouse gas emissions (GHG) and thus a reduced carbon footprint at economically reasonable costs. The costs and carbon footprints of two pasta types, produced with egg or pea protein, are calculated. Plant protein–based pasta products proved to cause 0.57 kg CO2 equivalents (CO2eq) (31%) per kg pasta less greenhouse gas emissions than animal-based pasta, while the cost of production increases by 10% to 3.00 €/kg pasta. PMID:28231112

Sampling theory for asynoptic satellite observations. I Space-time spectra, resolution, and aliasing. II - Fast Fourier synoptic mapping

NASA Technical Reports Server (NTRS)

Salby, M. L.

1982-01-01

An evaluation of the information content of asynoptic data taken in the form of nadir sonde and limb scan observations is presented, and a one-to-one correspondence is established between the alias-free data and twice-daily synoptic maps. Attention is given to space and time limitations of sampling and the orbital geometry is discussed. The sampling pattern is demonstrated to determine unique space-time spectra at all wavenumbers and frequencies. Spectral resolution and aliasing are explored, while restrictions on sampling and information content are defined. It is noted that irregular sampling at high latitudes produces spurious contamination effects. An Asynoptic Sampling Theorem is thereby formulated, as is a Synoptic Retrieval Theorem, in the second part of the article. In the latter, a procedure is developed for retrieving the unique correspondence between the asymptotic data and the synoptic maps. Applications examples are provided using data from the Nimbus-6 satellite.

Optical-domain subsampling for data efficient depth ranging in Fourier-domain optical coherence tomography

PubMed Central

Siddiqui, Meena; Vakoc, Benjamin J.

2012-01-01

Recent advances in optical coherence tomography (OCT) have led to higher-speed sources that support imaging over longer depth ranges. Limitations in the bandwidth of state-of-the-art acquisition electronics, however, prevent adoption of these advances into the clinical applications. Here, we introduce optical-domain subsampling as a method for imaging at high-speeds and over extended depth ranges but with a lower acquisition bandwidth than that required using conventional approaches. Optically subsampled laser sources utilize a discrete set of wavelengths to alias fringe signals along an extended depth range into a bandwidth limited frequency window. By detecting the complex fringe signals and under the assumption of a depth-constrained signal, optical-domain subsampling enables recovery of the depth-resolved scattering signal without overlapping artifacts from this bandwidth-limited window. We highlight key principles behind optical-domain subsampled imaging, and demonstrate this principle experimentally using a polygon-filter based swept-source laser that includes an intra-cavity Fabry-Perot (FP) etalon. PMID:23038343

Researcher liability for negligence in human subject research: informed consent and researcher malpractice actions.

PubMed

Jansson, Roger L

2003-02-01

Two sets of federal regulations, the "Common Rule" and Food and Drug Administration (FDA) regulations, govern human subject research that is either federally-funded or involves FDA regulated products. These regulations require, inter alia, that: (1) researchers obtain informed consent from human subjects, and (2) that an Institutional Review Board (IRB) independently review and approve the research protocol. Although the federal regulations do not provide an express cause of action against researchers, research subjects should be able to bring informed consent and malpractice actions against researchers by establishing a duty of care and standard of care. Researchers owe human subjects a duty of care analogous to the special relationship between physicians and patients. The federal regulations should provide the minimum standard of care for informed consent in human subject research, and complying with them should be a partial defense. In contrast, expert testimony should establish the standard of care for researcher malpractice, and IRB approval should be a partial defense.

X-ray Birefringence: A New Strategy for Determining Molecular Orientation in Materials.

PubMed

Palmer, Benjamin A; Edwards-Gau, Gregory R; Morte-Ródenas, Anabel; Kariuki, Benson M; Lim, Gin Keat; Harris, Kenneth D M; Dolbnya, Igor P; Collins, Stephen P

2012-11-01

While the phenomenon of birefringence is well-established in the case of visible radiation and is exploited in many fields (e.g., through the use of the polarizing optical microscope), the analogous phenomenon for X-rays has been a virtually neglected topic. Here, we demonstrate the scope and potential for exploiting X-ray birefringence to determine the orientational properties of specific types of bonds in solids. Specifically, orientational characteristics of C-Br bonds in the bromocyclohexane/thiourea inclusion compound are elucidated from X-ray birefringence measurements at energies close to the bromine K-edge, revealing inter alia the changes in the orientational distribution of the C-Br bonds associated with a low-temperature order-disorder phase transition. From fitting a theoretical model to the experimental data, reliable quantitative information on the orientational properties of the C-Br bonds is determined. The experimental strategy reported here represents the basis of a new approach for gaining insights into the orientational properties of molecules in anisotropic materials.

Cycle/Cocycle Oblique Projections on Oriented Graphs

NASA Astrophysics Data System (ADS)

Polettini, Matteo

2015-01-01

It is well known that the edge vector space of an oriented graph can be decomposed in terms of cycles and cocycles (alias cuts, or bonds), and that a basis for the cycle and the cocycle spaces can be generated by adding and removing edges to an arbitrarily chosen spanning tree. In this paper, we show that the edge vector space can also be decomposed in terms of cycles and the generating edges of cocycles (called cochords), or of cocycles and the generating edges of cycles (called chords). From this observation follows a construction in terms of oblique complementary projection operators. We employ this algebraic construction to prove several properties of unweighted Kirchhoff-Symanzik matrices, encoding the mutual superposition between cycles and cocycles. In particular, we prove that dual matrices of planar graphs have the same spectrum (up to multiplicities). We briefly comment on how this construction provides a refined formalization of Kirchhoff's mesh analysis of electrical circuits, which has lately been applied to generic thermodynamic networks.

[The three lives of the Count de Bonneval, alias Osman Pasha (1675-1747)].

PubMed

Fabre, André-Julien

2008-12-01

Count Claude-Alexandre de Bonneval (1675-1747), had a unusual existence: he had three consecutive lives: as an Officer in the Royal Guard of Louis XIV, as Major-General with Prince Emmanuel of Savoy and, finally, as Ottoman Pasha in Constantinople. He was a man of multiple facets: soldier and political adviser, swordsman and world traveller, friend of Casanova, Fenelon, Montesquieu and Leibniz. He was also an inveterate transgressor of every rule and, in the end, a renegade apostate. Many explanations have been offered for his astounding life: plain aristocratic frivolity, emotional instability, and possibly, in reference to a permanent quest for new adventures, countries or religions, a touch of transformism. Obviously, Bonneval concealed, behind a flamboyant personality, some sort of psychiatric fragility which might suggest, in retrospect, a "paranoid syndrome" but, certainly, no trace of what is common in psychopathic patients, a weariness of life. Bonneval loved each one of his three lives and the feeling was mutual.

Seeing Beyond the Naked Eye in a Planetarium

NASA Astrophysics Data System (ADS)

Fairall, A.

2005-12-01

I have a philosophy that the traditional naked-eye sky, as usually shown in planetariums, should only be an introductory step in portraying the Universe. Consequently, over the years I have produced 'inter alia' various versions of an enhanced Milky Way (the latest based on Axel Mellenger's panorama), the extragalactic sky and the radio sky for projection on planetarium domes. I also put together a three-dimensional planetarium show-the audience being equipped with ChromDepth(tm) spectacles- which stepped from the Solar System to the cosmic microwave background. The advent of digital technology now makes all this much easier. Currently, Labyrinth, a visualization program developed in-house, serves much the same function as the Hayden Planetarium's Partiview, but also permits rendering and fl y-throughs of large-scale structures. It allows viewers to explore local cosmography. Labyrinth can produce images that operate with the 3-D spectacles; we have also produced a version of Partiview that does the same.

A Comparison of Carbon Footprint and Production Cost of Different Pasta Products Based on Whole Egg and Pea Flour.

PubMed

Nette, Antonia; Wolf, Patricia; Schlüter, Oliver; Meyer-Aurich, Andreas

2016-03-04

Feed and food production are inter alia reasons for high greenhouse gas emissions. Greenhouse gas emissions could be reduced by the replacement of animal components with plant components in processed food products, such as pasta. The main components currently used for pasta are semolina, and water, as well as additional egg. The hypothesis of this paper is that the substitution of whole egg with plant-based ingredients, for example from peas, in such a product might lead to reduced greenhouse gas emissions (GHG) and thus a reduced carbon footprint at economically reasonable costs. The costs and carbon footprints of two pasta types, produced with egg or pea protein, are calculated. Plant protein-based pasta products proved to cause 0.57 kg CO₂ equivalents (CO₂eq) (31%) per kg pasta less greenhouse gas emissions than animal-based pasta, while the cost of production increases by 10% to 3.00 €/kg pasta.

The Effect of High Pressure Techniques on the Stability of Anthocyanins in Fruit and Vegetables

PubMed Central

Marszałek, Krystian; Woźniak, Łukasz; Kruszewski, Bartosz; Skąpska, Sylwia

2017-01-01

Anthocyanins are a group of phenolic compounds responsible for red, blue and violet colouration of many fruits, vegetables and flowers. The high content of these pigments is important as it influences directly their health promoting properties as well as the sensory quality of the product; however they are prone to degradation by, inter alia, elevated temperature and tissue enzymes. The traditional thermal methods of food preservation cause significant losses of these pigments. Thus, novel non-thermal techniques such as high pressure processing, high pressure carbon dioxide and high pressure homogenization are under consideration. In this review, the authors attempted to summarize the current knowledge of the impact of high pressure techniques on the stability of anthocyanins during processing and storage of fruit and vegetable products. Furthermore, the effect of the activity of enzymes involved in the degradation of these compounds has been described. The conclusions including comparisons of pressure-based methods with high temperature preservation techniques were presented. PMID:28134807

The Effect of High Pressure Techniques on the Stability of Anthocyanins in Fruit and Vegetables.

PubMed

Marszałek, Krystian; Woźniak, Łukasz; Kruszewski, Bartosz; Skąpska, Sylwia

2017-01-27

Anthocyanins are a group of phenolic compounds responsible for red, blue and violet colouration of many fruits, vegetables and flowers. The high content of these pigments is important as it influences directly their health promoting properties as well as the sensory quality of the product; however they are prone to degradation by, inter alia, elevated temperature and tissue enzymes. The traditional thermal methods of food preservation cause significant losses of these pigments. Thus, novel non-thermal techniques such as high pressure processing, high pressure carbon dioxide and high pressure homogenization are under consideration. In this review, the authors attempted to summarize the current knowledge of the impact of high pressure techniques on the stability of anthocyanins during processing and storage of fruit and vegetable products. Furthermore, the effect of the activity of enzymes involved in the degradation of these compounds has been described. The conclusions including comparisons of pressure-based methods with high temperature preservation techniques were presented.

The influence of heat treatment on properties of cold rolled alloyed steel and nickel superalloys sheets used in aircraft industry

NASA Astrophysics Data System (ADS)

Zaba, K.; Dul, I.; Puchlerska, S.

2017-02-01

Superalloys based on nickel and selected steels are widely used in the aerospace industry, because of their excellent mechanical properties, heat resistance and creep resistance. Metal sheets of these materials are plastically deformed and applied, inter alia, to critical components of aircraft engines. Due to their chemical composition these materials are hardly deformable. There are various methods to improve the formability of these materials, including plastic deformation at an elevated or high temperature, or a suitable heat treatment before forming process. The paper presents results of the metal sheets testing after heat treatment. For the research, sheets of two types of nickel superalloys type Inconel and of three types of steel were chosen. The materials were subjected to multivariate heat treatment at different temperature range and time. After this step, mechanical properties were examined according to the metal sheet rolling direction. The results were compared and the optimal type of pre-trial softening heat treatment for each of the materials was determined.

Moral absolutism and the double-effect exception: reflections on Joseph Boyle's Who is entitled to double effect?

PubMed

Donagan, A

1991-10-01

Joseph Boyle raises important questions about the place of the double-effect exception in absolutist moral theories. His own absolutist theory (held by many, but not all, Catholic moralists), which derives from the principles that fundamental human goods may not be intentionally violated, cannot dispense with such exceptions, although he rightly rejects some widely held views about what they are. By contrast, Kantian absolutist theory, which derives from the principle that lawful freedom must not be violated, has a corollary--that it is a duty, where possible, to coerce those who try to violate lawful freedom--which makes superfluous many of the double-effect exceptions Boyle allows. Other implications of the two theories are contrasted. Inter alia, it is argued that, in Boyle's theory, that a violation of a fundamental human good can be viewed as a cost proportionate to a benefit obtained, cannot yield a double-effect exception to the prohibition of intentionally violating that good, because paying a cost cannot be unintentional.

Mitigation of intra-channel nonlinearities using a frequency-domain Volterra series equalizer.

PubMed

Guiomar, Fernando P; Reis, Jacklyn D; Teixeira, António L; Pinto, Armando N

2012-01-16

We address the issue of intra-channel nonlinear compensation using a Volterra series nonlinear equalizer based on an analytical closed-form solution for the 3rd order Volterra kernel in frequency-domain. The performance of the method is investigated through numerical simulations for a single-channel optical system using a 20 Gbaud NRZ-QPSK test signal propagated over 1600 km of both standard single-mode fiber and non-zero dispersion shifted fiber. We carry on performance and computational effort comparisons with the well-known backward propagation split-step Fourier (BP-SSF) method. The alias-free frequency-domain implementation of the Volterra series nonlinear equalizer makes it an attractive approach to work at low sampling rates, enabling to surpass the maximum performance of BP-SSF at 2× oversampling. Linear and nonlinear equalization can be treated independently, providing more flexibility to the equalization subsystem. The parallel structure of the algorithm is also a key advantage in terms of real-time implementation.

Extracting salient sublexical units from written texts: “Emophon,” a corpus-based approach to phonological iconicity

PubMed Central

Aryani, Arash; Jacobs, Arthur M.; Conrad, Markus

2013-01-01

A growing body of literature in psychology, linguistics, and the neurosciences has paid increasing attention to the understanding of the relationships between phonological representations of words and their meaning: a phenomenon also known as phonological iconicity. In this article, we investigate how a text's intended emotional meaning, particularly in literature and poetry, may be reflected at the level of sublexical phonological salience and the use of foregrounded elements. To extract such elements from a given text, we developed a probabilistic model to predict the exceeding of a confidence interval for specific sublexical units concerning their frequency of occurrence within a given text contrasted with a reference linguistic corpus for the German language. Implementing this model in a computational application, we provide a text analysis tool which automatically delivers information about sublexical phonological salience allowing researchers, inter alia, to investigate effects of the sublexical emotional tone of texts based on current findings on phonological iconicity. PMID:24101907

Observations of Secondary Waves Generated from Interaction Between the 2-Day Wave and the Migrating Diurnal Tide.

NASA Astrophysics Data System (ADS)

Lieberman, R. S.; Riggin, D. M.; Siskind, D. E.; Nguyen, V.; Palo, S. E.; Mitchell, N. J.; Livesey, N. J.; Stober, G.; Wilhelm, S.; Jacobi, C.

2015-12-01

Nonlinear coupling between the migrating diurnal tide and the westward traveling quasi-2-day wave yields a westward-traveling "sum" wave with zonal wavenumber 4 and a period of 16 hours, and an eastward-traveling "difference" wave with a zonal wavenumber 2 and a period of 2 days. While the eastward 2-day wave has been reported in TIMED/SABER temperatures, the westward 16-hour wave lies outside SABER's Nyquist limits of resolution. To obtain simultaneous definitions of the parent and child waves, we examine hourly output from NOGAPS-ALPHA during January 2005, 2006 and 2008. The westward 16-hour wave maximizes in the winter hemisphere, and behaves like an inertia-gravity wave. The eastward 2-day wave maximizes at low latitudes, and exhibits a mixture of Kelvin and higher-order modes. The 16-hour and the eastward 2-day waves are of comparable magnitude, and alias to the same apparent frequency when viewed from the satellite perspective.

Using Mach threads to control DSN operational sequences

NASA Technical Reports Server (NTRS)

Urista, Juan

1993-01-01

The Link Monitor and Control Operator Assistant prototype (LMCOA) is a state-of-the-art, semiautomated monitor and control system based on an object-oriented design. The purpose of the LMCOA prototyping effort is to both investigate new technology (such as artificial intelligence) to support automation and to evaluate advances in information systems toward developing systems that take advantage of the technology. The emergence of object-oriented design methodology has enabled a major change in how software is designed and developed. This paper describes how the object-oriented approach was used to design and implement the LMCOA and the results of operational testing. The LMCOA is implemented on a NeXT workstation using the Mach operating system and the Objective-C programming language.

Design of a Model Execution Framework: Repetitive Object-Oriented Simulation Environment (ROSE)

NASA Technical Reports Server (NTRS)

Gray, Justin S.; Briggs, Jeffery L.

2008-01-01

The ROSE framework was designed to facilitate complex system analyses. It completely divorces the model execution process from the model itself. By doing so ROSE frees the modeler to develop a library of standard modeling processes such as Design of Experiments, optimizers, parameter studies, and sensitivity studies which can then be applied to any of their available models. The ROSE framework accomplishes this by means of a well defined API and object structure. Both the API and object structure are presented here with enough detail to implement ROSE in any object-oriented language or modeling tool.

Engineering Design Thinking and Information Gathering. Final Report. Research in Engineering and Technology Education

ERIC Educational Resources Information Center

Mentzer, Nathan

2011-01-01

The objective of this research was to explore the relationship between information access and design solution quality of high school students presented with an engineering design problem. This objective is encompassed in the research question driving this inquiry: How does information access impact the design process? This question has emerged in…

Concept Maps as Instructional Tools for Improving Learning of Phase Transitions in Object-Oriented Analysis and Design

ERIC Educational Resources Information Center

Shin, Shin-Shing

2016-01-01

Students attending object-oriented analysis and design (OOAD) courses typically encounter difficulties transitioning from requirements analysis to logical design and then to physical design. Concept maps have been widely used in studies of user learning. The study reported here, based on the relationship of concept maps to learning theory and…

Optomechanical design concept for the Giant Magellan Telescope Multi-object Astronomical and Cosmological Spectrograph (GMACS)

NASA Astrophysics Data System (ADS)

Prochaska, Travis; Sauseda, Marcus; Beck, James; Schmidt, Luke; Cook, Erika; DePoy, Darren L.; Marshall, Jennifer L.; Ribeiro, Rafael; Taylor, Keith; Jones, Damien; Froning, Cynthia; Pak, Soojong; Mendes de Oliveira, Claudia; Papovich, Casey; Ji, Tae-Geun; Lee, Hye-In

2016-08-01

We describe a preliminary conceptual optomechanical design for GMACS, a wide-field, multi-object, moderate resolution optical spectrograph for the Giant Magellan Telescope (GMT). This paper describes the details of the GMACS optomechanical conceptual design, including the requirements and considerations leading to the design, mechanisms, optical mounts, and predicted flexure performance.

Monitoring What Governments “Give for” and “Spend on” Vaccine Procurement: Vaccine Procurement Assistance and Vaccine Procurement Baseline

PubMed Central

Nelson, E. A. S.; Bloom, David E.; Mahoney, Richard T.

2014-01-01

Background The Global Vaccine Action Plan will require, inter alia, the mobilization of financial resources from donors and national governments – both rich and poor. Vaccine Procurement Assistance (VPA) and Vaccine Procurement Baseline (VPB) are two metrics that could measure government performance and track resources in this arena. VPA is proposed as a new subcategory of Official Development Assistance (ODA) given for the procurement of vaccines and VPB is a previously suggested measure of the share of Gross Domestic Product (GDP) that governments spend on their own vaccine procurement. Objective To determine realistic targets for VPA and VPB. Methods Organization for Economic Co-Operation and Development (OECD) and World Bank data for 2009 were analyzed to determine the proportions of bilateral ODA from the 23 Development Assistance Committee (DAC) countries disbursed (as % of GDP in current US$) for infectious disease control. DAC country contributions to the GAVI Alliance for 2009 were assessed as a measure of multilateral donor support for vaccines and immunization programs. Findings In 2009, total DAC bilateral ODA was 0.16% of global GDP and 0.25% of DAC GDP. As a percentage of GDP, Norway (0.013%) and United Kingdom (0.0085%) disbursed the greatest proportion of bilateral ODA for infectious disease control, and Norway (0.024%) and Canada (0.008%) made the greatest contributions to the GAVI Alliance. In 2009 0.02% of DAC GDP was US$7.61 billion and 0.02% of the GDP of the poorest 117 countries was US$2.88 billion. Conclusions Adopting 0.02% GDP as minimum targets for both VPA and VPB is based on realistic estimates of what both developed and developing countries should spend, and can afford to spend, to jointly ensure procurement of vaccines recommended by national and global bodies. New OECD purpose codes are needed to specifically track ODA disbursed for a) vaccine procurement; and b) immunization programs. PMID:24586899

The Role of Compost in Stabilizing the Microbiological and Biochemical Properties of Zinc-Stressed Soil.

PubMed

Strachel, Rafał; Wyszkowska, Jadwiga; Baćmaga, Małgorzata

2017-01-01

The progressive development of civilization and intensive industrialization has contributed to the global pollution of the natural environment by heavy metals, especially the soil. Degraded soils generally contain less organic matter, and thus, their homeostasis is more often disturbed, which in turn manifests in changes in biological and physicochemical properties of the soil. Therefore, new possibilities and solutions for possible neutralization of these contaminations are sought, inter alia, through reclamation of degraded land. At present, the use of additives supporting the reclamation process that exhibit heavy metal-sorbing properties is becoming increasingly important in soil recovery. Research was conducted to determine the role of compost in stabilizing the microbial and biochemical balance of the soil due to the significant problem of heavy metal-contaminated areas. The study was conducted on loamy sand, to which zinc was applied at the following doses: 0, 250, 500, 750, 1000, and 1250 mg Zn 2+  kg -1 DM of soil. Compost was introduced to the appropriate objects calculated on the basis of organic carbon content in the amount of 0, 10, and 20 g C org  kg -1 DM of soil. The study was conducted over a period of 20 weeks, maintaining soil moisture at 50% capillary water capacity. Zinc significantly modified soil microbiome status. The abundance of microorganisms and their biological diversity and the enzymatic activity of the soil were affected. The negative effects of contaminating zinc doses were alleviated by the introduction of compost into the soil. Organic fertilization led to microbial growth intensification and increased biochemical activity of the soil already 2 weeks after compost application. These effects persisted throughout the experiment. Therefore, it can be stated that the use of compost is an appropriate method for restoring normal functions of soil ecosystems contaminated with zinc.

Patient's rights in Poland against the background of new regulations.

PubMed

Rabiega-Przylecka, Agnieszka

2012-03-01

Patient rights are the specification of general human rights. The rights define the patient position in relation to health institutions or medical professions providing, broadly understood, health services. The protection system of patient rights outlined by international legal and ethical regulations is detailed to specific social, political and economic realities by internal legal systems of individual states. Imperfections of the Polish health care system in relation to achieving adequate protection of patient rights, resulting, inter alia, from the lack of comprehensive regulation of the matter of patient rights, led the legislature to introduce new regulations concerning this aspect to the Polish legal order. The new Act of 6 November 2008 on Patient Rights and the Patient Rights Ombudsman (binding from 5 March 2009) is the first universally binding legal act in the Polish legal system entirely dealing with the matter of patient rights. It regulates the rights of the patient and correlated with them obligations of health care providers (public and non-public) irrespectively of both the legal form providers, as well as the sources of funding of the benefits provided. In particular, the Act states: the patient right to health services, right to obtain information, right to confidentiality of patient-linked information, right to consent to obtain health services, right to respect privacy and dignity of the patients, right to medical records and objecting to the doctor's opinion or decision, right to respect private and family life, right to pastoral care. The new regulations--besides the specification of the catalogue of patient rights--reinforced the institutional protection of patient rights by establishing a new central public administrative body having jurisdiction to protect patient rights--the Patient Rights Ombudsman. Poland, like other European countries, makes an attempt to improve the protection of patient rights. The introduction of the Act entirely devoted to patient rights is undoubtedly an important step towards creating the optimum protection of the patient.

40 CFR 96.314 - Objections concerning CAIR designated representative.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Objections concerning CAIR designated... concerning CAIR designated representative. (a) Once a complete certificate of representation under § 96.313... other communication submitted to the permitting authority or the Administrator concerning the...

48 CFR 7.105 - Contents of written acquisition plans.

Code of Federal Regulations, 2011 CFR

2011-10-01

... appropriate, discuss the cost model used to develop life-cycle-cost estimates. (ii) Design-to-cost. Describe the design-to-cost objective(s) and underlying assumptions, including the rationale for quantity... of stimulating industry involvement during design and development in recommending the most...

48 CFR 7.105 - Contents of written acquisition plans.

Code of Federal Regulations, 2012 CFR

2012-10-01

... appropriate, discuss the cost model used to develop life-cycle-cost estimates. (ii) Design-to-cost. Describe the design-to-cost objective(s) and underlying assumptions, including the rationale for quantity... of stimulating industry involvement during design and development in recommending the most...

48 CFR 7.105 - Contents of written acquisition plans.

Code of Federal Regulations, 2013 CFR

2013-10-01

... appropriate, discuss the cost model used to develop life-cycle-cost estimates. (ii) Design-to-cost. Describe the design-to-cost objective(s) and underlying assumptions, including the rationale for quantity... of stimulating industry involvement during design and development in recommending the most...

Development of a Dynamically Configurable,Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation

NASA Technical Reports Server (NTRS)

Afjeh, Abdollah A.; Reed, John A.

2003-01-01

This research is aimed at developing a neiv and advanced simulation framework that will significantly improve the overall efficiency of aerospace systems design and development. This objective will be accomplished through an innovative integration of object-oriented and Web-based technologies ivith both new and proven simulation methodologies. The basic approach involves Ihree major areas of research: Aerospace system and component representation using a hierarchical object-oriented component model which enables the use of multimodels and enforces component interoperability. Collaborative software environment that streamlines the process of developing, sharing and integrating aerospace design and analysis models. . Development of a distributed infrastructure which enables Web-based exchange of models to simplify the collaborative design process, and to support computationally intensive aerospace design and analysis processes. Research for the first year dealt with the design of the basic architecture and supporting infrastructure, an initial implementation of that design, and a demonstration of its application to an example aircraft engine system simulation.

Designing Inquiry Starters

NASA Astrophysics Data System (ADS)

Kluger-Bell, B.

2010-12-01

The term "Inquiry Starter" comes from the Institute for Inquiry's model for teaching and learning science through inquiry. It refers to the first phase of an inquiry activity where learners engage in actions that stimulate their curiosity and generate questions for further investigation. In the Professional Development Program, staff and participants have designed a wide variety of inquiry activities with a number of variations on the inquiry starter. This has provided a laboratory for examining inquiry starter design. In this paper, I describe and examine in detail the elements of this design and how the design of those elements is related to achieving learning objectives. There are a number of important common objectives in all inquiry starters. For example, all starters must define a domain for investigation and engage the learner's curiosity in that domain. There are also critical differences in learning objectives depending on the content area being studied, the learners' background knowledge and skills, and many other factors. In this paper I examine designs for both of these types of objectives.

Definition ofthe Design Trajectory and Entry Flight Corridor for the NASA Orion Exploration Mission 1 Entry Trajectory Using an Integrated Approach and Optimization

NASA Technical Reports Server (NTRS)

McNamara, Luke W.; Braun, Robert D.

2014-01-01

One of the key design objectives of NASA's Orion Exploration Mission 1 (EM- 1) is to execute a guided entry trajectory demonstrating GN&C capability. The focus of this paper is defining the flyable entry corridor for EM-1 taking into account multiple subsystem constraints such as complex aerothermal heating constraints, aerothermal heating objectives, landing accuracy constraints, structural load limits, Human-System-Integration-Requirements, Service Module debris disposal limits and other flight test objectives. During the EM-1 Design Analysis Cycle 1 design challenges came up that made defining the flyable entry corridor for the EM-1 mission critical to mission success. This document details the optimization techniques that were explored to use with the 6-DOF ANTARES simulation to assist in defining the design entry interface state and entry corridor with respect to key flight test constraints and objectives.

Control design for future agile fighters

NASA Technical Reports Server (NTRS)

Murphy, Patrick C.; Davidson, John B.

1991-01-01

The CRAFT control design methodology is presented. CRAFT stands for the design objectives addressed, namely, Control power, Robustness, Agility, and Flying Qualities Tradeoffs. The approach combines eigenspace assignment, which allows for direct specification of eigenvalues and eigenvectors, and a graphical approach for representing control design metrics that captures numerous design goals in one composite illustration. The methodology makes use of control design metrics from four design objective areas, namely, control power, robustness, agility, and flying qualities. An example of the CRAFT methodology as well as associated design issues are presented.

Towards Robust Designs Via Multiple-Objective Optimization Methods

NASA Technical Reports Server (NTRS)

Man Mohan, Rai

2006-01-01

Fabricating and operating complex systems involves dealing with uncertainty in the relevant variables. In the case of aircraft, flow conditions are subject to change during operation. Efficiency and engine noise may be different from the expected values because of manufacturing tolerances and normal wear and tear. Engine components may have a shorter life than expected because of manufacturing tolerances. In spite of the important effect of operating- and manufacturing-uncertainty on the performance and expected life of the component or system, traditional aerodynamic shape optimization has focused on obtaining the best design given a set of deterministic flow conditions. Clearly it is important to both maintain near-optimal performance levels at off-design operating conditions, and, ensure that performance does not degrade appreciably when the component shape differs from the optimal shape due to manufacturing tolerances and normal wear and tear. These requirements naturally lead to the idea of robust optimal design wherein the concept of robustness to various perturbations is built into the design optimization procedure. The basic ideas involved in robust optimal design will be included in this lecture. The imposition of the additional requirement of robustness results in a multiple-objective optimization problem requiring appropriate solution procedures. Typically the costs associated with multiple-objective optimization are substantial. Therefore efficient multiple-objective optimization procedures are crucial to the rapid deployment of the principles of robust design in industry. Hence the companion set of lecture notes (Single- and Multiple-Objective Optimization with Differential Evolution and Neural Networks ) deals with methodology for solving multiple-objective Optimization problems efficiently, reliably and with little user intervention. Applications of the methodologies presented in the companion lecture to robust design will be included here. The evolutionary method (DE) is first used to solve a relatively difficult problem in extended surface heat transfer wherein optimal fin geometries are obtained for different safe operating base temperatures. The objective of maximizing the safe operating base temperature range is in direct conflict with the objective of maximizing fin heat transfer. This problem is a good example of achieving robustness in the context of changing operating conditions. The evolutionary method is then used to design a turbine airfoil; the two objectives being reduced sensitivity of the pressure distribution to small changes in the airfoil shape and the maximization of the trailing edge wedge angle with the consequent increase in airfoil thickness and strength. This is a relevant example of achieving robustness to manufacturing tolerances and wear and tear in the presence of other objectives.

Geoengineering as a design problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kravitz, Ben; MacMartin, Douglas G.; Wang, Hailong

2016-01-01

Understanding the climate impacts of solar geoengineering is essential for evaluating its benefits and risks. Most previous simulations have prescribed a particular strategy and evaluated its modeled effects. Here we turn this approach around by first choosing example climate objectives and then designing a strategy to meet those objectives in climate models. There are four essential criteria for designing a strategy: (i) an explicit specification of the objectives, (ii) defining what climate forcing agents to modify so the objectives are met, (iii) a method for managing uncertainties, and (iv) independent verification of the strategy in an evaluation model. We demonstrate this design perspective throughmore » two multi-objective examples. First, changes in Arctic temperature and the position of tropical precipitation due to CO 2 increases are offset by adjusting high-latitude insolation in each hemisphere independently. Second, three different latitude-dependent patterns of insolation are modified to offset CO 2-induced changes in global mean temperature, interhemispheric temperature asymmetry, and the Equator-to-pole temperature gradient. In both examples, the "design" and "evaluation" models are state-of-the-art fully coupled atmosphere–ocean general circulation models.« less

A hybrid multi-objective imperialist competitive algorithm and Monte Carlo method for robust safety design of a rail vehicle

NASA Astrophysics Data System (ADS)

Nejlaoui, Mohamed; Houidi, Ajmi; Affi, Zouhaier; Romdhane, Lotfi

2017-10-01

This paper deals with the robust safety design optimization of a rail vehicle system moving in short radius curved tracks. A combined multi-objective imperialist competitive algorithm and Monte Carlo method is developed and used for the robust multi-objective optimization of the rail vehicle system. This robust optimization of rail vehicle safety considers simultaneously the derailment angle and its standard deviation where the design parameters uncertainties are considered. The obtained results showed that the robust design reduces significantly the sensitivity of the rail vehicle safety to the design parameters uncertainties compared to the determinist one and to the literature results.

Identification of vehicle suspension parameters by design optimization

NASA Astrophysics Data System (ADS)

Tey, J. Y.; Ramli, R.; Kheng, C. W.; Chong, S. Y.; Abidin, M. A. Z.

2014-05-01

The design of a vehicle suspension system through simulation requires accurate representation of the design parameters. These parameters are usually difficult to measure or sometimes unavailable. This article proposes an efficient approach to identify the unknown parameters through optimization based on experimental results, where the covariance matrix adaptation-evolutionary strategy (CMA-es) is utilized to improve the simulation and experimental results against the kinematic and compliance tests. This speeds up the design and development cycle by recovering all the unknown data with respect to a set of kinematic measurements through a single optimization process. A case study employing a McPherson strut suspension system is modelled in a multi-body dynamic system. Three kinematic and compliance tests are examined, namely, vertical parallel wheel travel, opposite wheel travel and single wheel travel. The problem is formulated as a multi-objective optimization problem with 40 objectives and 49 design parameters. A hierarchical clustering method based on global sensitivity analysis is used to reduce the number of objectives to 30 by grouping correlated objectives together. Then, a dynamic summation of rank value is used as pseudo-objective functions to reformulate the multi-objective optimization to a single-objective optimization problem. The optimized results show a significant improvement in the correlation between the simulated model and the experimental model. Once accurate representation of the vehicle suspension model is achieved, further analysis, such as ride and handling performances, can be implemented for further optimization.

Application of two procedures for dual-point design of transonic airfoils

NASA Technical Reports Server (NTRS)

Mineck, Raymond E.; Campbell, Richard L.; Allison, Dennis O.

1994-01-01

Two dual-point design procedures were developed to reduce the objective function of a baseline airfoil at two design points. The first procedure to develop a redesigned airfoil used a weighted average of the shapes of two intermediate airfoils redesigned at each of the two design points. The second procedure used a weighted average of two pressure distributions obtained from an intermediate airfoil redesigned at each of the two design points. Each procedure was used to design a new airfoil with reduced wave drag at the cruise condition without increasing the wave drag or pitching moment at the climb condition. Two cycles of the airfoil shape-averaging procedure successfully designed a new airfoil that reduced the objective function and satisfied the constraints. One cycle of the target (desired) pressure-averaging procedure was used to design two new airfoils that reduced the objective function and came close to satisfying the constraints.

An NAFP Project: Use of Object Oriented Methodologies and Design Patterns to Refactor Software Design

NASA Technical Reports Server (NTRS)

Shaykhian, Gholam Ali; Baggs, Rhoda

2007-01-01

In the early problem-solution era of software programming, functional decompositions were mainly used to design and implement software solutions. In functional decompositions, functions and data are introduced as two separate entities during the design phase, and are followed as such in the implementation phase. Functional decompositions make use of refactoring through optimizing the algorithms, grouping similar functionalities into common reusable functions, and using abstract representations of data where possible; all these are done during the implementation phase. This paper advocates the usage of object-oriented methodologies and design patterns as the centerpieces of refactoring software solutions. Refactoring software is a method of changing software design while explicitly preserving its external functionalities. The combined usage of object-oriented methodologies and design patterns to refactor should also benefit the overall software life cycle cost with improved software.

Optimal Design of Gradient Materials and Bi-Level Optimization of Topology Using Targets (BOTT)

NASA Astrophysics Data System (ADS)

Garland, Anthony

The objective of this research is to understand the fundamental relationships necessary to develop a method to optimize both the topology and the internal gradient material distribution of a single object while meeting constraints and conflicting objectives. Functionally gradient material (FGM) objects possess continuous varying material properties throughout the object, and they allow an engineer to tailor individual regions of an object to have specific mechanical properties by locally modifying the internal material composition. A variety of techniques exists for topology optimization, and several methods exist for FGM optimization, but combining the two together is difficult. Understanding the relationship between topology and material gradient optimization enables the selection of an appropriate model and the development of algorithms, which allow engineers to design high-performance parts that better meet design objectives than optimized homogeneous material objects. For this research effort, topology optimization means finding the optimal connected structure with an optimal shape. FGM optimization means finding the optimal macroscopic material properties within an object. Tailoring the material constitutive matrix as a function of position results in gradient properties. Once, the target macroscopic properties are known, a mesostructure or a particular material nanostructure can be found which gives the target material properties at each macroscopic point. This research demonstrates that topology and gradient materials can both be optimized together for a single part. The algorithms use a discretized model of the domain and gradient based optimization algorithms. In addition, when considering two conflicting objectives the algorithms in this research generate clear 'features' within a single part. This tailoring of material properties within different areas of a single part (automated design of 'features') using computational design tools is a novel benefit of gradient material designs. A macroscopic gradient can be achieved by varying the microstructure or the mesostructures of an object. The mesostructure interpretation allows for more design freedom since the mesostructures can be tuned to have non-isotropic material properties. A new algorithm called Bi-level Optimization of Topology using Targets (BOTT) seeks to find the best distribution of mesostructure designs throughout a single object in order to minimize an objective value. On the macro level, the BOTT algorithm optimizes the macro topology and gradient material properties within the object. The BOTT algorithm optimizes the material gradient by finding the best constitutive matrix at each location with the object. In order to enhance the likelihood that a mesostructure can be generated with the same equivalent constitutive matrix, the variability of the constitutive matrix is constrained to be an orthotropic material. The stiffness in the X and Y directions (of the base coordinate system) can change in addition to rotating the orthotropic material to align with the loading at each region. Second, the BOTT algorithm designs mesostructures with macroscopic properties equal to the target properties found in step one while at the same time the algorithm seeks to minimize material usage in each mesostructure. The mesostructure algorithm maximizes the strain energy of the mesostructures unit cell when a pseudo strain is applied to the cell. A set of experiments reveals the fundamental relationship between target cell density and the strain (or pseudo strain) applied to a unit cell and the output effective properties of the mesostructure. At low density, a few mesostructure unit cell design are possible, while at higher density the mesostructure unit cell designs have many possibilities. Therefore, at low densities the effective properties of the mesostructure are a step function of the applied pseudo strain. At high densities, the effective properties of the mesostructure are continuous function of the applied pseudo strain. Finally, the macro and mesostructure designs are coordinated so that the macro and meso levels agree on the material properties at each macro region. In addition, a coordination effort seeks to coordinate the boundaries of adjacent mesostructure designs so that the macro load path is transmitted from one mesostructure design to its neighbors. The BOTT algorithm has several advantages over existing algorithms within the literature. First, the BOTT algorithm significantly reduces the computational power required to run the algorithm. Second, the BOTT algorithm indirectly enforces a minimum mesostructure density constraint which increases the manufacturability of the final design. Third, the BOTT algorithm seeks to transfer the load from one mesostructure to its neighbors by coordinating the boundaries of adjacent mesostructure designs. However, the BOTT algorithm can still be improved since it may have difficulty converging due to the step function nature of the mesostructure design problem at low density.

Lens Systems Incorporating A Zero Power Corrector Part 3 New Four-Element Microscope Objectives With Flat Field Or High Power

NASA Astrophysics Data System (ADS)

Klee, H. W.; McDowell, M. W.

1986-02-01

The use of the zero power corrector concept has been extended to the design of microscope objectives. Several four and five-element designs are described which include a flat field 10x design of 0.25 numerical aperture and a 40x design of 0.65 numerical aperture.

Optimum Design of High Speed Prop-Rotors

NASA Technical Reports Server (NTRS)

Chattopadhyay, Aditi

1992-01-01

The objective of this research is to develop optimization procedures to provide design trends in high speed prop-rotors. The necessary disciplinary couplings are all considered within a closed loop optimization process. The procedures involve the consideration of blade aeroelastic, aerodynamic performance, structural and dynamic design requirements. Further, since the design involves consideration of several different objectives, multiobjective function formulation techniques are developed.

Knowledge Discovery for Transonic Regional-Jet Wing through Multidisciplinary Design Exploration

NASA Astrophysics Data System (ADS)

Chiba, Kazuhisa; Obayashi, Shigeru; Morino, Hiroyuki

Data mining is an important facet of solving multi-objective optimization problem. Because it is one of the effective manner to discover the design knowledge in the multi-objective optimization problem which obtains large data. In the present study, data mining has been performed for a large-scale and real-world multidisciplinary design optimization (MDO) to provide knowledge regarding the design space. The MDO among aerodynamics, structures, and aeroelasticity of the regional-jet wing was carried out using high-fidelity evaluation models on the adaptive range multi-objective genetic algorithm. As a result, nine non-dominated solutions were generated and used for tradeoff analysis among three objectives. All solutions evaluated during the evolution were analyzed for the tradeoffs and influence of design variables using a self-organizing map to extract key features of the design space. Although the MDO results showed the inverted gull-wings as non-dominated solutions, one of the key features found by data mining was the non-gull wing geometry. When this knowledge was applied to one optimum solution, the resulting design was found to have better performance compared with the original geometry designed in the conventional manner.

Study of Vermont: A Curriculum Designed for Grades 4-6.

ERIC Educational Resources Information Center

Dubuque, Martha L.

Designed for use in grades 4-6, this guide consists of four basic units related to the study of Vermont: Indian Civilization, Vermont History, Geography and Economics, and Cities and Towns. Each unit lists key concepts, content objectives, skills objectives, and related objectives. Next, specialized vocabulary as well as common, essential…

Remembering Math: The Design of Digital Learning Objects to Spark Professional Learning

ERIC Educational Resources Information Center

Halverson, Richard; Wolfenstein, Moses; Williams, Caroline C.; Rockman, Charles

2009-01-01

This article describes how the design of digital learning objects can spark professional learning. The challenge was to build learning objects that would help experienced special education teachers, who had been teaching in math classes, to demonstrate their proficiency in middle and secondary school mathematics on the PRAXIS examination. While…

Lens Systems Incorporating A Zero Power Corrector Objectives And Magnifiers For Night Vision Applications

NASA Astrophysics Data System (ADS)

McDowell, M. W.; Klee, H. W.

1986-02-01

The use of the zero power corrector concept has been extended to the design of objective lenses and magnifiers suitable for use in night vision goggles. A novel design which can be used as either an f/1.2 objective or an f/2 magnifier is also described.

A Case Study: Developing Learning Objects with an Explicit Learning Design

ERIC Educational Resources Information Center

Watson, Julie

2010-01-01

In learning object design an emphasis on visual attractiveness and high technological impact has seemed to persist while content frequently reflects a lack of clear pedagogical basis for the application of learning objects for online learning. Most apparent is the absence of supportive scaffolding for the student user; interactivity built on an…

Dynamic Learning Objects to Teach Java Programming Language

ERIC Educational Resources Information Center

Narasimhamurthy, Uma; Al Shawkani, Khuloud

2010-01-01

This article describes a model for teaching Java Programming Language through Dynamic Learning Objects. The design of the learning objects was based on effective learning design principles to help students learn the complex topic of Java Programming. Visualization was also used to facilitate the learning of the concepts. (Contains 1 figure and 2…

On the Improvement of Convergence Performance for Integrated Design of Wind Turbine Blade Using a Vector Dominating Multi-objective Evolution Algorithm

NASA Astrophysics Data System (ADS)

Wang, L.; Wang, T. G.; Wu, J. H.; Cheng, G. P.

2016-09-01

A novel multi-objective optimization algorithm incorporating evolution strategies and vector mechanisms, referred as VD-MOEA, is proposed and applied in aerodynamic- structural integrated design of wind turbine blade. In the algorithm, a set of uniformly distributed vectors is constructed to guide population in moving forward to the Pareto front rapidly and maintain population diversity with high efficiency. For example, two- and three- objective designs of 1.5MW wind turbine blade are subsequently carried out for the optimization objectives of maximum annual energy production, minimum blade mass, and minimum extreme root thrust. The results show that the Pareto optimal solutions can be obtained in one single simulation run and uniformly distributed in the objective space, maximally maintaining the population diversity. In comparison to conventional evolution algorithms, VD-MOEA displays dramatic improvement of algorithm performance in both convergence and diversity preservation for handling complex problems of multi-variables, multi-objectives and multi-constraints. This provides a reliable high-performance optimization approach for the aerodynamic-structural integrated design of wind turbine blade.

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion.

PubMed

Lluis, Anna; Schedel, Michaela; Liu, Jing; Illi, Sabina; Depner, Martin; von Mutius, Erika; Kabesch, Michael; Schaub, Bianca

2011-06-01

In a genome-wide association study, genetic variants on chromosome 17q21 were strongly associated with childhood asthma and orosomucoid 1-like 3 (ORMDL3) gene expression. Regulation of the 17q21 locus and its immunologic relevance early in life have not been well characterized. We investigated the relation between polymorphisms and mRNA expression of 17q21 locus genes and their influence on T-cell subsets in cord blood. In 200 children of our cord blood study, 17q21 polymorphisms were genotyped by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Gene expression was assessed for ORMDL3; gasdermin A (GSDMA, alias GSDM1); gasdermin B (GSDMB, alias GSDML); Ikaros family zinc finger 3 (ZNFN1A3), zona pellucida binding protein 2 (ZPBP2); and proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 (PSMD3), in cord blood mononuclear cells (CBMCs) and for ORMDL3 in peripheral blood (real-time RT-PCR). Mononuclear cells were assessed before and after microbial (lipid A/peptidoglycan), phytohemagglutinin, or allergen (Der p 1) stimulation. Regulatory T-associated markers (forkhead box protein 3, glucocorticoid-induced TNF receptor, lymphocyte activation gene 3 mRNA expression) and T(h)2/T(h)1/T(h)17 cytokines were examined. In CBMCs, single genetic risk variants within 17q21 were associated with increased ORMDL3 (Der p 1 stimulation; P ≤ .01) and GSDMA expression (phytohemagglutinin/Der p 1 stimulation; P ≤ .05). Children homozygous for all 4 risk alleles for 17q21 tagging single nucleotide polymorphisms showed increased expression for ORMDL3 (Der p 1; P = .002) and GSDMA (phytohemagglutinin; P = .0009/Der p 1; P = .004). CBMC ORMDL3 expression was lower compared with PBMCs (P ≤ .0003) and increased in both CBMC and PBMC after stimulation (phytohemagglutinin/lipid A/peptidoglycan/Der p 1; P ≤ .006 and phytohemagglutinin/peptidoglycan; P < .05, respectively). No correlation between 17q21 polymorphisms and regulatory T/T(h)2/T(h)1 lineages was detectable. However, 17q21 risk allele carriers showed significantly increased IL-17 secretion (unstimulated, phytohemagglutinin-stimulated). Our results suggest an association of 17q21 polymorphisms with ORMDL3, GSDMA expression, and IL-17 secretion early in life. These observations may imply a functional role of the 17q21 locus affecting T-cell development during immune maturation. Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Aliasing of the Schumann resonance background signal by sprite-associated Q-bursts

NASA Astrophysics Data System (ADS)

Guha, Anirban; Williams, Earle; Boldi, Robert; Sátori, Gabriella; Nagy, Tamás; Bór, József; Montanyà, Joan; Ortega, Pascal

2017-12-01

The Earth's naturally occurring Schumann resonances (SR) are composed of a quasi-continuous background component and a larger-amplitude, short-duration transient component, otherwise called 'Q-burst' (Ogawa et al., 1967). Sprites in the mesosphere are also known to accompany the energetic positive ground flashes that launch the Q-bursts (Boccippio et al., 1995). Spectra of the background Schumann Resonances (SR) require a natural stabilization period of ∼10-12 min for the three conspicuous modal parameters to be derived from Lorentzian fitting. Before the spectra are computed and the fitting process is initiated, the raw time series data need to be properly filtered for local cultural noise, narrow band interference as well as for large transients in the form of global Q-bursts. Mushtak and Williams (2009) describe an effective technique called Isolated Lorentzian (I-LOR), in which, the contributions from local cultural and various other noises are minimized to a great extent. An automated technique based on median filtering of time series data has been developed. These special lightning flashes are known to have greater contribution in the ELF range (below 1 kHz) compared to general negative CG strikes (Huang et al., 1999; Cummer et al., 2006). The global distributions of these Q-bursts have been studied by Huang et al. (1999) Rhode Island, USA by wave impedance methods from single station ELF measurements at Rhode Island, USA and from Japan Hobara et al. (2006). The present work aims to demonstrate the effect of Q-bursts on SR background spectra using GPS time-stamped observation of TLEs. It is observed that the Q-bursts selected for the present work do alias the background spectra over a 5-s period, though the amplitudes of these Q-bursts are far below the background threshold of 16 Core Standard Deviation (CSD) so that they do not strongly alias the background spectra of 10-12 min duration. The examination of one exceptional Q-burst shows that appreciable spectral aliasing can occur even when 12-min spectral integrations are considered. The statistical result shows that for a 12-min spectrum, events above 16 CSD are capable of producing significant frequency aliasing of the modal frequencies, although the intensity aliasing might have a negligible effect unless the events are exceptionally large (∼200 CSD). The spectral CSD methodology may be used to extract the time of arrival of the Q-burst transients. This methodology may be combined with a hyperbolic ranging, thus becoming an effective tool to detect TLEs globally with a modest number of networked observational stations.

An investigation of constraint-based component-modeling for knowledge representation in computer-aided conceptual design

NASA Technical Reports Server (NTRS)

Kolb, Mark A.

1990-01-01

Originally, computer programs for engineering design focused on detailed geometric design. Later, computer programs for algorithmically performing the preliminary design of specific well-defined classes of objects became commonplace. However, due to the need for extreme flexibility, it appears unlikely that conventional programming techniques will prove fruitful in developing computer aids for engineering conceptual design. The use of symbolic processing techniques, such as object-oriented programming and constraint propagation, facilitate such flexibility. Object-oriented programming allows programs to be organized around the objects and behavior to be simulated, rather than around fixed sequences of function- and subroutine-calls. Constraint propagation allows declarative statements to be understood as designating multi-directional mathematical relationships among all the variables of an equation, rather than as unidirectional assignments to the variable on the left-hand side of the equation, as in conventional computer programs. The research has concentrated on applying these two techniques to the development of a general-purpose computer aid for engineering conceptual design. Object-oriented programming techniques are utilized to implement a user-extensible database of design components. The mathematical relationships which model both geometry and physics of these components are managed via constraint propagation. In addition, to this component-based hierarchy, special-purpose data structures are provided for describing component interactions and supporting state-dependent parameters. In order to investigate the utility of this approach, a number of sample design problems from the field of aerospace engineering were implemented using the prototype design tool, Rubber Airplane. The additional level of organizational structure obtained by representing design knowledge in terms of components is observed to provide greater convenience to the program user, and to result in a database of engineering information which is easier both to maintain and to extend.

Controller design for wind turbine load reduction via multiobjective parameter synthesis

NASA Astrophysics Data System (ADS)

Hoffmann, A. F.; Weiβ, F. A.

2016-09-01

During the design process for a wind turbine load reduction controller many different, sometimes conflicting requirements must be fulfilled simultaneously. If the requirements can be expressed as mathematical criteria, such a design problem can be solved by a criterion-vector and multi-objective design optimization. The software environment MOPS (Multi-Objective Parameter Synthesis) supports the engineer for such a design optimization. In this paper MOPS is applied to design a multi-objective load reduction controller for the well-known DTU 10 MW reference wind turbine. A significant reduction in the fatigue criteria especially the blade damage can be reached by the use of an additional Individual Pitch Controller (IPC) and an additional tower damper. This reduction is reached as a trade-off with an increase of actuator load.

Web-Based Learning Design Tool

ERIC Educational Resources Information Center

Bruno, F. B.; Silva, T. L. K.; Silva, R. P.; Teixeira, F. G.

2012-01-01

Purpose: The purpose of this paper is to propose a web-based tool that enables the development and provision of learning designs and its reuse and re-contextualization as generative learning objects, aimed at developing educational materials. Design/methodology/approach: The use of learning objects can facilitate the process of production and…

Design and Implementation of an Interface Editor for the Amadeus Multi- Relational Database Front-end System

DTIC Science & Technology

1993-03-25

application of Object-Oriented Programming (OOP) and Human-Computer Interface (HCI) design principles. Knowledge gained from each topic has been incorporated...through the ap- plication of Object-Oriented Programming (OOP) and Human-Computer Interface (HCI) design principles. Knowledge gained from each topic has...programming and Human-Computer Interface (HCI) design. Knowledge gained from each is applied to the design of a Form-based interface for database data

Design Guide for Earth System Science Education: Common Student Learning Objectives and Special Pedagogical Approaches

NASA Astrophysics Data System (ADS)

Baker, D.

2006-12-01

As part of the NASA-supported undergraduate Earth System Science Education (ESSE) program, fifty-seven institutions have developed and implemented a wide range of Earth system science (ESS) courses, pedagogies, and evaluation tools. The Teaching, Learning, and Evaluation section of USRA's online ESSE Design Guide showcases these ESS learning environments. This Design Guide section also provides resources for faculty who wish to develop ESS courses. It addresses important course design issues including prior student knowledge and interests, student learning objectives, learning resources, pedagogical approaches, and assessments tied to student learning objectives. The ESSE Design Guide provides links to over 130 ESS course syllabi at introductory, senior, and graduate levels. ESS courses over the past 15 years exhibit common student learning objectives and unique pedagogical approaches. From analysis of ESS course syllabi, seven common student learning objectives emerged: 1) demonstrate systems thinking, 2) develop an ESS knowledge base, 3) apply ESS to the human dimension, 4) expand and apply analytical skills, 5) improve critical thinking skills, 6) build professional/career skills, and 7) acquire an enjoyment and appreciation for science. To meet these objectives, ESSE often requires different ways of teaching than in traditional scientific disciplines. This presentation will highlight some especially successful pedagogical approaches for creating positive and engaging ESS learning environments.

Algorithmic Mechanism Design of Evolutionary Computation.

PubMed

Pei, Yan

2015-01-01

We consider algorithmic design, enhancement, and improvement of evolutionary computation as a mechanism design problem. All individuals or several groups of individuals can be considered as self-interested agents. The individuals in evolutionary computation can manipulate parameter settings and operations by satisfying their own preferences, which are defined by an evolutionary computation algorithm designer, rather than by following a fixed algorithm rule. Evolutionary computation algorithm designers or self-adaptive methods should construct proper rules and mechanisms for all agents (individuals) to conduct their evolution behaviour correctly in order to definitely achieve the desired and preset objective(s). As a case study, we propose a formal framework on parameter setting, strategy selection, and algorithmic design of evolutionary computation by considering the Nash strategy equilibrium of a mechanism design in the search process. The evaluation results present the efficiency of the framework. This primary principle can be implemented in any evolutionary computation algorithm that needs to consider strategy selection issues in its optimization process. The final objective of our work is to solve evolutionary computation design as an algorithmic mechanism design problem and establish its fundamental aspect by taking this perspective. This paper is the first step towards achieving this objective by implementing a strategy equilibrium solution (such as Nash equilibrium) in evolutionary computation algorithm.

Algorithmic Mechanism Design of Evolutionary Computation

PubMed Central

2015-01-01

We consider algorithmic design, enhancement, and improvement of evolutionary computation as a mechanism design problem. All individuals or several groups of individuals can be considered as self-interested agents. The individuals in evolutionary computation can manipulate parameter settings and operations by satisfying their own preferences, which are defined by an evolutionary computation algorithm designer, rather than by following a fixed algorithm rule. Evolutionary computation algorithm designers or self-adaptive methods should construct proper rules and mechanisms for all agents (individuals) to conduct their evolution behaviour correctly in order to definitely achieve the desired and preset objective(s). As a case study, we propose a formal framework on parameter setting, strategy selection, and algorithmic design of evolutionary computation by considering the Nash strategy equilibrium of a mechanism design in the search process. The evaluation results present the efficiency of the framework. This primary principle can be implemented in any evolutionary computation algorithm that needs to consider strategy selection issues in its optimization process. The final objective of our work is to solve evolutionary computation design as an algorithmic mechanism design problem and establish its fundamental aspect by taking this perspective. This paper is the first step towards achieving this objective by implementing a strategy equilibrium solution (such as Nash equilibrium) in evolutionary computation algorithm. PMID:26257777

A rudimentary database for three-dimensional objects using structural representation

NASA Technical Reports Server (NTRS)

Sowers, James P.

1987-01-01

A database which enables users to store and share the description of three-dimensional objects in a research environment is presented. The main objective of the design is to make it a compact structure that holds sufficient information to reconstruct the object. The database design is based on an object representation scheme which is information preserving, reasonably efficient, and yet economical in terms of the storage requirement. The determination of the needed data for the reconstruction process is guided by the belief that it is faster to do simple computations to generate needed data/information for construction than to retrieve everything from memory. Some recent techniques of three-dimensional representation that influenced the design of the database are discussed. The schema for the database and the structural definition used to define an object are given. The user manual for the software developed to create and maintain the contents of the database is included.

Enhanced Multiobjective Optimization Technique for Comprehensive Aerospace Design. Part A

NASA Technical Reports Server (NTRS)

Chattopadhyay, Aditi; Rajadas, John N.

1997-01-01

A multidisciplinary design optimization procedure which couples formal multiobjectives based techniques and complex analysis procedures (such as computational fluid dynamics (CFD) codes) developed. The procedure has been demonstrated on a specific high speed flow application involving aerodynamics and acoustics (sonic boom minimization). In order to account for multiple design objectives arising from complex performance requirements, multiobjective formulation techniques are used to formulate the optimization problem. Techniques to enhance the existing Kreisselmeier-Steinhauser (K-S) function multiobjective formulation approach have been developed. The K-S function procedure used in the proposed work transforms a constrained multiple objective functions problem into an unconstrained problem which then is solved using the Broyden-Fletcher-Goldfarb-Shanno (BFGS) algorithm. Weight factors are introduced during the transformation process to each objective function. This enhanced procedure will provide the designer the capability to emphasize specific design objectives during the optimization process. The demonstration of the procedure utilizes a computational Fluid dynamics (CFD) code which solves the three-dimensional parabolized Navier-Stokes (PNS) equations for the flow field along with an appropriate sonic boom evaluation procedure thus introducing both aerodynamic performance as well as sonic boom as the design objectives to be optimized simultaneously. Sensitivity analysis is performed using a discrete differentiation approach. An approximation technique has been used within the optimizer to improve the overall computational efficiency of the procedure in order to make it suitable for design applications in an industrial setting.

Wing Configuration Impact on Design Optimums for a Subsonic Passenger Transport

NASA Technical Reports Server (NTRS)

Wells, Douglas P.

2014-01-01

This study sought to compare four aircraft wing configurations at a conceptual level using a multi-disciplinary optimization (MDO) process. The MDO framework used was created by Georgia Institute of Technology and Virginia Polytechnic Institute and State University. They created a multi-disciplinary design and optimization environment that could capture the unique features of the truss-braced wing (TBW) configuration. The four wing configurations selected for the study were a low wing cantilever installation, a high wing cantilever, a strut-braced wing, and a single jury TBW. The mission that was used for this study was a 160 passenger transport aircraft with a design range of 2,875 nautical miles at the design payload, flown at a cruise Mach number of 0.78. This paper includes discussion and optimization results for multiple design objectives. Five design objectives were chosen to illustrate the impact of selected objective on the optimization result: minimum takeoff gross weight (TOGW), minimum operating empty weight, minimum block fuel weight, maximum start of cruise lift-to-drag ratio, and minimum start of cruise drag coefficient. The results show that the design objective selected will impact the characteristics of the optimized aircraft. Although minimum life cycle cost was not one of the objectives, TOGW is often used as a proxy for life cycle cost. The low wing cantilever had the lowest TOGW followed by the strut-braced wing.

Trading Robustness Requirements in Mars Entry Trajectory Design

NASA Technical Reports Server (NTRS)

Lafleur, Jarret M.

2009-01-01

One of the most important metrics characterizing an atmospheric entry trajectory in preliminary design is the size of its predicted landing ellipse. Often, requirements for this ellipse are set early in design and significantly influence both the expected scientific return from a particular mission and the cost of development. Requirements typically specify a certain probability level (6-level) for the prescribed ellipse, and frequently this latter requirement is taken at 36. However, searches for the justification of 36 as a robustness requirement suggest it is an empirical rule of thumb borrowed from non-aerospace fields. This paper presents an investigation into the sensitivity of trajectory performance to varying robustness (6-level) requirements. The treatment of robustness as a distinct objective is discussed, and an analysis framework is presented involving the manipulation of design variables to effect trades between performance and robustness objectives. The scenario for which this method is illustrated is the ballistic entry of an MSL-class Mars entry vehicle. Here, the design variable is entry flight path angle, and objectives are parachute deploy altitude performance and error ellipse robustness. Resulting plots show the sensitivities between these objectives and trends in the entry flight path angles required to design to these objectives. Relevance to the trajectory designer is discussed, as are potential steps for further development and use of this type of analysis.

Negotiating designs of multi-purpose reservoir systems in international basins

NASA Astrophysics Data System (ADS)

Geressu, Robel; Harou, Julien

2016-04-01

Given increasing agricultural and energy demands, coordinated management of multi-reservoir systems could help increase production without further stressing available water resources. However, regional or international disputes about water-use rights pose a challenge to efficient expansion and management of many large reservoir systems. Even when projects are likely to benefit all stakeholders, agreeing on the design, operation, financing, and benefit sharing can be challenging. This is due to the difficulty of considering multiple stakeholder interests in the design of projects and understanding the benefit trade-offs that designs imply. Incommensurate performance metrics, incomplete knowledge on system requirements, lack of objectivity in managing conflict and difficulty to communicate complex issue exacerbate the problem. This work proposes a multi-step hybrid multi-objective optimization and multi-criteria ranking approach for supporting negotiation in water resource systems. The approach uses many-objective optimization to generate alternative efficient designs and reveal the trade-offs between conflicting objectives. This enables informed elicitation of criteria weights for further multi-criteria ranking of alternatives. An ideal design would be ranked as best by all stakeholders. Resource-sharing mechanisms such as power-trade and/or cost sharing may help competing stakeholders arrive at designs acceptable to all. Many-objective optimization helps suggests efficient designs (reservoir site, its storage size and operating rule) and coordination levels considering the perspectives of multiple stakeholders simultaneously. We apply the proposed approach to a proof-of-concept study of the expansion of the Blue Nile transboundary reservoir system.

Automated solar collector installation design including ability to define heterogeneous design preferences

DOEpatents

Wayne, Gary; Frumkin, Alexander; Zaydman, Michael; Lehman, Scott; Brenner, Jules

2014-04-29

Embodiments may include systems and methods to create and edit a representation of a worksite, to create various data objects, to classify such objects as various types of pre -defined "features" with attendant properties and layout constraints. As part of or in addition to classification, an embodiment may include systems and methods to create, associate, and edit intrinsic and extrinsic properties to these objects. A design engine may apply of design rules to the features described above to generate one or more solar collectors installation design alternatives, including generation of on-screen and/or paper representations of the physical layout or arrangement of the one or more design alternatives. Embodiments may also include definition of one or more design apertures, each of which may correspond to boundaries in which solar collector layouts should comply with distinct sets of user-defined design preferences. Distinct apertures may provide heterogeneous regions of collector layout according to the user-defined design preferences.

Automated solar collector installation design including ability to define heterogeneous design preferences

DOEpatents

Wayne, Gary; Frumkin, Alexander; Zaydman, Michael; Lehman, Scott; Brenner, Jules

2013-01-08

Embodiments may include systems and methods to create and edit a representation of a worksite, to create various data objects, to classify such objects as various types of pre-defined "features" with attendant properties and layout constraints. As part of or in addition to classification, an embodiment may include systems and methods to create, associate, and edit intrinsic and extrinsic properties to these objects. A design engine may apply of design rules to the features described above to generate one or more solar collectors installation design alternatives, including generation of on-screen and/or paper representations of the physical layout or arrangement of the one or more design alternatives. Embodiments may also include definition of one or more design apertures, each of which may correspond to boundaries in which solar collector layouts should comply with distinct sets of user-defined design preferences. Distinct apertures may provide heterogeneous regions of collector layout according to the user-defined design preferences.

How to design and fly your humanly space object in space?

NASA Astrophysics Data System (ADS)

Balint, Tibor; Hall, Ashley

2016-06-01

Today's space exploration, both robotic- and human-exploration driven, is dominated by objects and artifacts which are mostly conceived, designed and built through technology and engineering approaches. They are functional, reliable, safe, and expensive. Building on considerations and concepts established in an earlier paper, we can state that the current approach leaves very little room for art and design based objects, as organizations-typically led by engineers, project and business managers-see the inclusion of these disciplines and artifacts as nice to have instead of a genuine need, let alone requirement. In this paper we will offer initial discussions about where design and engineering practices are different or similar and how to bridge them and highlight the benefits that domains such as design or art can offer to space exploration. Some of the design considerations and approaches will be demonstrated through the double diamond of divergence-convergence cycles of design, leading to an experimental piece called a ;cybernetic astronaut chair;, which was designed as a form of abstraction and discussion point to highlight a subset of concepts and ideas that designers may consider when designing objects for space use, with attention to human-centered or humanly interactions. Although there are few suggested functional needs for chairs in space, they can provide reassuring emotional experiences from home, while being far away from home. In zero gravity, back-to-back seats provide affordances-or add variety in a cybernetic sense-to accommodate two astronauts simultaneously, while implying the circularity of cybernetics in a rather symbolic way. The cybernetic astronaut chair allows us to refine the three-actor model proposed in a previous paper, defining the circular interactions between the artist or designer; object or process; and user or observer. We will also dedicate a brief discussion to the process of navigating through the complex regulations of space agencies, from solicitations through development and testing, to space flight. The provided insights to designers and artists, related to agency-driven processes and requirements, may help to deconvolute the steps and may lead to flying their objects or artifacts in space.

Conceptual FOM design tool

NASA Astrophysics Data System (ADS)

Krause, Lee S.; Burns, Carla L.

2000-06-01

This paper discusses the research currently in progress to develop the Conceptual Federation Object Model Design Tool. The objective of the Conceptual FOM (C-FOM) Design Tool effort is to provide domain and subject matter experts, such as scenario developers, with automated support for understanding and utilizing available HLA simulation and other simulation assets during HLA Federation development. The C-FOM Design Tool will import Simulation Object Models from HLA reuse repositories, such as the MSSR, to populate the domain space that will contain all the objects and their supported interactions. In addition, the C-FOM tool will support the conversion of non-HLA legacy models into HLA- compliant models by applying proven abstraction techniques against the legacy models. Domain experts will be able to build scenarios based on the domain objects and interactions in both a text and graphical form and export a minimal FOM. The ability for domain and subject matter experts to effectively access HLA and non-HLA assets is critical to the long-term acceptance of the HLA initiative.

Aeroelastic Optimization Study Based on X-56A Model

NASA Technical Reports Server (NTRS)

Li, Wesley; Pak, Chan-Gi

2014-01-01

A design process which incorporates the object-oriented multidisciplinary design, analysis, and optimization (MDAO) tool and the aeroelastic effects of high fidelity finite element models to characterize the design space was successfully developed and established. Two multidisciplinary design optimization studies using an object-oriented MDAO tool developed at NASA Armstrong Flight Research Center were presented. The first study demonstrates the use of aeroelastic tailoring concepts to minimize the structural weight while meeting the design requirements including strength, buckling, and flutter. A hybrid and discretization optimization approach was implemented to improve accuracy and computational efficiency of a global optimization algorithm. The second study presents a flutter mass balancing optimization study. The results provide guidance to modify the fabricated flexible wing design and move the design flutter speeds back into the flight envelope so that the original objective of X-56A flight test can be accomplished.

Comparison of Evolutionary (Genetic) Algorithm and Adjoint Methods for Multi-Objective Viscous Airfoil Optimizations

NASA Technical Reports Server (NTRS)

Pulliam, T. H.; Nemec, M.; Holst, T.; Zingg, D. W.; Kwak, Dochan (Technical Monitor)

2002-01-01

A comparison between an Evolutionary Algorithm (EA) and an Adjoint-Gradient (AG) Method applied to a two-dimensional Navier-Stokes code for airfoil design is presented. Both approaches use a common function evaluation code, the steady-state explicit part of the code,ARC2D. The parameterization of the design space is a common B-spline approach for an airfoil surface, which together with a common griding approach, restricts the AG and EA to the same design space. Results are presented for a class of viscous transonic airfoils in which the optimization tradeoff between drag minimization as one objective and lift maximization as another, produces the multi-objective design space. Comparisons are made for efficiency, accuracy and design consistency.

Home Economics. Exploration of Clothing Management, Production and Service Occupations. Performance Objectives. Criterion Measures.

ERIC Educational Resources Information Center

Duval County School Board, Jacksonville, FL.

Several intermediate performance objectives and corresponding criterion measures are presented for each of five terminal objectives for a 12- to 18-week course designed to provide students in grades 8 or 9 with opportunities to explore a broad range of clothing management, production, and service occupations. The course was designed to provide…

Guiding bioprocess design by microbial ecology.

PubMed

Volmer, Jan; Schmid, Andreas; Bühler, Bruno

2015-06-01

Industrial bioprocess development is driven by profitability and eco-efficiency. It profits from an early stage definition of process and biocatalyst design objectives. Microbial bioprocess environments can be considered as synthetic technical microbial ecosystems. Natural systems follow Darwinian evolution principles aiming at survival and reproduction. Technical systems objectives are eco-efficiency, productivity, and profitable production. Deciphering technical microbial ecology reveals differences and similarities of natural and technical systems objectives, which are discussed in this review in view of biocatalyst and process design and engineering strategies. Strategies for handling opposing objectives of natural and technical systems and for exploiting and engineering natural properties of microorganisms for technical systems are reviewed based on examples. This illustrates the relevance of considering microbial ecology for bioprocess design and the potential for exploitation by synthetic biology strategies. Copyright © 2015 Elsevier Ltd. All rights reserved.

Requirements' Role in Mobilizing and Enabling Design Conversation

NASA Astrophysics Data System (ADS)

Bergman, Mark

Requirements play a critical role in a design conversation of systems and products. Product and system design exists at the crossroads of problems, solutions and requirements. Requirements contextualize problems and solutions, pointing the way to feasible outcomes. These are captured with models and detailed specifications. Still, stakeholders need to be able to understand one-another using shared design representations in order to mobilize bias and transform knowledge towards legitimized, desired results. Many modern modeling languages, including UML, as well as detailed, logic-based specifications are beyond the comprehension of key stakeholders. Hence, they inhibit, rather than promote design conversation. Improved design boundary objects (DBO), especially design requirements boundary objects (DRBO), need to be created and refined to improve the communications between principals. Four key features of design boundary objects that improve and promote design conversation are discussed in detail. A systems analysis and design case study is presented which demonstrates these features in action. It describes how a small team of analysts worked with key stakeholders to mobilize and guide a complex system design discussion towards an unexpected, yet desired outcome within a short time frame.

Knowledge of Metabolic Syndrome in Chinese Adults: Implications for Health Education

ERIC Educational Resources Information Center

Lo, Sally Wai Sze; Chair, Sek Ying; Lee, Iris Fung Kam

2016-01-01

Objective: The objective of this study was to assess knowledge of metabolic syndrome (MS) among Chinese adults and provide directions for designing healthcare promotion schemes for improving MS awareness in the community. Design: The study adopted a cross-sectional design and a convenience sampling method. Method: Chinese adults aged 18-65 years…

Associative Memories for Supercomputers

DTIC Science & Technology

1992-12-01

the Si/PLZT technology. Finally, the associative memory system design is presented. 14. SUBJECT TERMS IS NUMBER OF PAGES 60 Memory, Associative Memory...Hybrid lens design ...................................................................... 3 3. ASSOCIATIVE MEMORY STUDY...of California, san Diego 1. OBJECTIVES Our objective during the funding period, July 14 1989 to January 13 1991, was to design and study the

Multi-point objective-oriented sequential sampling strategy for constrained robust design

NASA Astrophysics Data System (ADS)

Zhu, Ping; Zhang, Siliang; Chen, Wei

2015-03-01

Metamodelling techniques are widely used to approximate system responses of expensive simulation models. In association with the use of metamodels, objective-oriented sequential sampling methods have been demonstrated to be effective in balancing the need for searching an optimal solution versus reducing the metamodelling uncertainty. However, existing infilling criteria are developed for deterministic problems and restricted to one sampling point in one iteration. To exploit the use of multiple samples and identify the true robust solution in fewer iterations, a multi-point objective-oriented sequential sampling strategy is proposed for constrained robust design problems. In this article, earlier development of objective-oriented sequential sampling strategy for unconstrained robust design is first extended to constrained problems. Next, a double-loop multi-point sequential sampling strategy is developed. The proposed methods are validated using two mathematical examples followed by a highly nonlinear automotive crashworthiness design example. The results show that the proposed method can mitigate the effect of both metamodelling uncertainty and design uncertainty, and identify the robust design solution more efficiently than the single-point sequential sampling approach.

Multi-Objective Optimization of a Turbofan for an Advanced, Single-Aisle Transport

NASA Technical Reports Server (NTRS)

Berton, Jeffrey J.; Guynn, Mark D.

2012-01-01

Considerable interest surrounds the design of the next generation of single-aisle commercial transports in the Boeing 737 and Airbus A320 class. Aircraft designers will depend on advanced, next-generation turbofan engines to power these airplanes. The focus of this study is to apply single- and multi-objective optimization algorithms to the conceptual design of ultrahigh bypass turbofan engines for this class of aircraft, using NASA s Subsonic Fixed Wing Project metrics as multidisciplinary objectives for optimization. The independent design variables investigated include three continuous variables: sea level static thrust, wing reference area, and aerodynamic design point fan pressure ratio, and four discrete variables: overall pressure ratio, fan drive system architecture (i.e., direct- or gear-driven), bypass nozzle architecture (i.e., fixed- or variable geometry), and the high- and low-pressure compressor work split. Ramp weight, fuel burn, noise, and emissions are the parameters treated as dependent objective functions. These optimized solutions provide insight to the ultrahigh bypass engine design process and provide information to NASA program management to help guide its technology development efforts.

Embedded object concept: case balancing two-wheeled robot

NASA Astrophysics Data System (ADS)

Vallius, Tero; Röning, Juha

2007-09-01

This paper presents the Embedded Object Concept (EOC) and a telepresence robot system which is a test case for the EOC. The EOC utilizes common object-oriented methods used in software by applying them to combined Lego-like software-hardware entities. These entities represent objects in object-oriented design methods, and they are the building blocks of embedded systems. The goal of the EOC is to make the designing of embedded systems faster and easier. This concept enables people without comprehensive knowledge in electronics design to create new embedded systems, and for experts it shortens the design time of new embedded systems. We present the current status of a telepresence robot created with Atomi-objects, which is the name for our implementation of the embedded objects. The telepresence robot is a relatively complex test case for the EOC. The robot has been constructed using incremental device development, which is made possible by the architecture of the EOC. The robot contains video and audio exchange capability and a controlling system for driving with two wheels. The robot consists of Atomi-objects, demonstrating the suitability of the EOC for prototyping and easy modifications, and proving the capabilities of the EOC by realizing a function that normally requires a computer. The computer counterpart is a regular PC with audio and video capabilities running with a robot control application. The robot is functional and successfully tested.