Science.gov

Sample records for alimentos secos comerciales

  1. 27 CFR 9.59 - Arroyo Seco.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.59 Arroyo Seco. (a) Name. The name of the viticultural area described in this section is “Arroyo Seco.” (b) Approved maps. The appropriate maps for determining the boundaries of the Arroyo Seco viticultural area...

  2. 27 CFR 9.59 - Arroyo Seco.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.59 Arroyo Seco. (a) Name. The name of the viticultural area described in this section is “Arroyo Seco.” (b) Approved maps. The appropriate maps for determining the boundaries of the Arroyo Seco viticultural area...

  3. 27 CFR 9.59 - Arroyo Seco.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.59 Arroyo Seco. (a) Name. The name of the viticultural area described in this section is “Arroyo Seco.” (b) Approved maps. The appropriate maps for determining the boundaries of the Arroyo Seco viticultural area...

  4. ARROYO SECO ROADLESS AREA, CALIFORNIA.

    USGS Publications Warehouse

    Powell, Robert E.; Gabby, Peter N.

    1984-01-01

    Situated in the southwestern San Gabriel Mountains in Los Angeles County, California, the Arroyo Seco Roadless Area encompasses about 8 sq mi within the Angeles National Forest. On the basis of geologic mapping, a geochemical stream-sediment survey, and a survey of mines, quarries, and prospects, the area has a probable resource potential for small gold occurrences in the southern part of the area. Sand, gravel, and stone suitable for construction materials are found in the roadless area. Because of their regional association with gold mineralization, the thin and poorly exposed mafic dikes in the Echo Granite, the Mount Lowe Granodiorite, and the Precambrian gneiss in and around the roadless area offer the most promising avenue for additional study of the resource potential of the area.

  5. Rancho Seco--Decommissioning Update

    SciTech Connect

    Newey, J. M.; Ronningen, E. T.; Snyder, M. W.

    2003-02-26

    The Rancho Seco Nuclear Generating Station ceased operation in June of 1989 and entered an extended period of SAFSTOR to allow funds to accumulate for dismantlement. Incremental dismantlement was begun in 1997 of steam systems and based on the successful completion of work, the Sacramento Municipal Utility District (SMUD) board of directors approved full decommissioning in July 1999. A schedule has been developed for completion of decommissioning by 2008, allowing decommissioning funds to accumulate until they are needed. Systems removal began in the Auxiliary Building in October of 1999 and in the Reactor Building in January of 2000. Systems dismantlement continues in the Reactor Building and should be completed by the end of 2003. System removal is near completion in the Auxiliary Building with removal of the final liquid waste tanks in progress. The spent fuel has been moved to dry storage in an onsite ISFSI, with completion on August 21, 2002. The spent fuel racks are currently being removed from the pool, packaged and shipped, and then the pool will be cleaned. Also in the last year the reactor coolant pumps and primary piping were removed and shipped. Characterization and planning work for the reactor vessel and internals is also in progress with various cut-up and/or disposal options being evaluated. In the year ahead the remaining systems in the Reactor Building will be removed, packaged and sent for disposal, including the pressurizer. Work will be started on embedded and underground piping and the large outdoor tanks. Building survey and decontamination will begin. RFP's for removal of the vessel and internals and the steam generators are planned to fix the cost of those components. If the costs are consistent with current estimates the work will go forward. If they are not, hardened SAFSTOR/entombment may be considered.

  6. 12. VIEW OF ARROYO SECO CHANNEL SEEN FROM SAN FERNANDO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF ARROYO SECO CHANNEL SEEN FROM SAN FERNANDO BRIDGE. NOTE VIADUCTS AND TUNNEL PORTAL AT REAR. LOOKING 234°SW. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

  7. ARROYO SECO PARKWAY SOUTHBOUND LANES AND EXIT RAMP TO ORANGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARROYO SECO PARKWAY SOUTHBOUND LANES AND EXIT RAMP TO ORANGE GROVE AVENUE. ORANGE GROVE AVENUE BRIDGE IN REAR. LOOKING 278°W - Arroyo Seco Parkway, Orange Grove Avenue Bridge, Milepost 30.59, Los Angeles, Los Angeles County, CA

  8. 32. AERIAL VIEW OF ARROYO SECO PARKWAY AT AVENUE 60. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. AERIAL VIEW OF ARROYO SECO PARKWAY AT AVENUE 60. AT&SF RAILROAD BRIDGE AT BACK. NOTE AVENUE 60 ACCESS ROAD AND BRIDGE OVER ARROYO SECO. DEBS PARK HILL AT CENTER IS LOCATION OF CAMERA POSITION FOR PHOTOGRAPHS CA-265-13, CA265-14, AND CA-265-V-4. LOOKING NE. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  9. 8. ARROYO SECO PARKWAY AND NORTH SIDE OF YORK BOULEVARD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. ARROYO SECO PARKWAY AND NORTH SIDE OF YORK BOULEVARD BRIDGE. NOTE SUPER ELEVATED CURVES AND GRADE SEPARATION OF NORTH AND SOUTHBOUND LANES. LOOKING 196"S. - Arroyo Seco Parkway, York Boulevard Bridge, Milepost 29.50, Los Angeles, Los Angeles County, CA

  10. 40. ARROYO SECO PARKWAY, ROAD VIEW DETAIL NEAR YORK BOULEVARD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. ARROYO SECO PARKWAY, ROAD VIEW DETAIL NEAR YORK BOULEVARD EXIT. NOTE SUPER ELEVATED CURVE WITH BANKING OF BOTH SIDES OF PARKWAY. NOTE GUARD WALL AND CURBING. NOTE PARALLEL SURFACE STREET (BRIDEWELL ST.). LOOKING 208°WSW. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  11. ARROYO SECO PARKWAY SOUTHBOUND LANES AND EXIT RAMP TO ORANGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARROYO SECO PARKWAY SOUTHBOUND LANES AND EXIT RAMP TO ORANGE GROVE AVENUE. ORANGE GROVE AVENUE BRIDGE IN REAR. NOTE IRRIGATION AND DRAINAGE FEATURES AT RIGHT. LOOKING 248°WSW - Arroyo Seco Parkway, Orange Grove Avenue Bridge, Milepost 30.59, Los Angeles, Los Angeles County, CA

  12. Synthesis of the B-seco limonoid core scaffold

    PubMed Central

    Bruss, Hanna; Schuster, Hannah; Martinez, Rémi; Kaiser, Markus; Antonchick, Andrey P

    2014-01-01

    Summary Synthetic investigations towards the structurally complex and highly decorated framework of B-seco limonoid natural products by means of a [3,3]-sigmatropic rearrangement are described. Detailed model studies reveal, that an Ireland–Claisen rearrangement can be employed to construct the central C9–C10 bond thereby giving access to the B-seco limonoid scaffold. However, application of the developed strategy ended up failing in more complex and sterically demanding systems. PMID:24605139

  13. Rancho Seco-Planning for Large Components

    SciTech Connect

    Gardiner, D. E.; Newey, J. M; Snyder, M. W.

    2002-02-27

    The Rancho Seco Nuclear Generating Station ceased operation in June of 1989 and entered an extended period of Safestor to allow funds to accumulate for dismantlement. Incremental dismantlement was begun in 1997 of steam systems and based on the successful work to date, the Sacramento Municipal Utility District (SMUD) board of directors approved full decommissioning in July 1999. A schedule has been developed for completion of decommissioning by 2008, allowing decommissioning funds to accumulate until they are needed. Systems removal began in the Auxiliary Building in October of 1999 and in the Reactor Building in January of 2000. Systems dismantlement continues in the Reactor Building and the Auxiliary Building and should be completed by mid 2003. The Spent Fuel is currently being moved to dry storage in an onsite ISFSI, with completion scheduled for late 2002. The personnel resources on site are currently assigned to support both the dry fuel project and the dismantlement of the facility. Once fuel movement is complete more resources will be provided for dismantlement. Characterization of major components other than the vessel is complete and planning for their removal is in progress with various cut-up and/or shipping options being evaluated. Planning for the vessel and internals removal is being performed. The relatively slow pace of the work allows careful evaluation of cost-effective options as they become available in the industry.

  14. The seco-iridoid pathway from Catharanthus roseus

    PubMed Central

    Miettinen, Karel; Dong, Lemeng; Navrot, Nicolas; Schneider, Thomas; Burlat, Vincent; Pollier, Jacob; Woittiez, Lotte; van der Krol, Sander; Lugan, Raphaël; Ilc, Tina; Verpoorte, Robert; Oksman-Caldentey, Kirsi-Marja; Martinoia, Enrico; Bouwmeester, Harro; Goossens, Alain; Memelink, Johan; Werck-Reichhart, Danièle

    2014-01-01

    The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and vincristine, MIAs used as anticancer drugs, are produced by Catharanthus roseus in extremely low levels, leading to high market prices and poor availability. Their biotechnological production is hampered by the fragmentary knowledge of their biosynthesis. Here we report the discovery of the last four missing steps of the (seco)iridoid biosynthesis pathway. Expression of the eight genes encoding this pathway, together with two genes boosting precursor formation and two downstream alkaloid biosynthesis genes, in an alternative plant host, allows the heterologous production of the complex MIA strictosidine. This confirms the functionality of all enzymes of the pathway and highlights their utility for synthetic biology programmes towards a sustainable biotechnological production of valuable (seco)iridoids and alkaloids with pharmaceutical and agricultural applications. PMID:24710322

  15. The SECO suite of codes for site Performance Assessment

    SciTech Connect

    Roache, P.J.

    1993-03-01

    Modeling for Performance Assessment of the Waste Isolation Pilot Plant (WIPP ) has led to development of the SECO suite of codes for groundwater flow, particle tracking, and transport. Algorithm and code developments include the following areas: facilitation of grid convergence tests in multiple domains; correct treatment of transmissivity factors for unconfined aquifers; efficient multigrid algorithms; a formulation of brine Darcy flow equations that uses freshwater head as the dependent able; boundary-fitted coordinates; temporal high order particle tracking; an efficient and accurate implicit Finite Volume TVD algorithm for radionuclide transport in (possibly) fractured porous media; accurate calculation of advection via a flux-based modified method of characteristics; and Quality Assurance procedures.

  16. 13. ARROYO SECO PARKWAY SEEN FROM DEBS PARK (APPROXIMATELY 34° ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. ARROYO SECO PARKWAY SEEN FROM DEBS PARK (APPROXIMATELY 34° 7' BY 118° 11' ON USGS LOS ANGELES QUADRANGLE). AVENUE 60 BRIDGE AT CENTER. LOOKING 240° WSW. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  17. Syntheses of all the stereoisomers of butanol type 1,7-seco-2,7'-cyclolignane.

    PubMed

    Yamauchi, Satoshi; Tomiyama, Chisato; Wukirsari, Tuti; Nishiwaki, Hisashi

    2014-01-01

    All the stereoisomers of butanol type 1,7-seco-2,7'-cyclolignane were stereoselectively synthesized by employing (S)- and (R)-Evans' auxiliaries to construct the stereochemistry. (+)- and (-)-Kadangustin J and their diastereomers were also prepared. The optical purity of the synthesized butanol type 1,7-seco-2,7'-cyclolignane was more than 99%ee.

  18. Antiproliferative Activity of seco-Oxacassanes from Acacia schaffneri.

    PubMed

    Torres-Valencia, J Martín; Motilva, Virginia; Manríquez-Torres, J Jesús; García-Mauriño, Sofía; López-Lázaro, Miguel; Zbakh, Hanaa; Calderón-Montaño, José M; Gómez-Hurtado, Mario A; Gayosso-De-Lucio, Juan A; Cerda-García-Rojas, Carlos M; Joseph-Nathan, Pedro

    2015-06-01

    This work reports the antiproliferative activity of seco-oxacassanes 1-3, isolated from Acacia schaffneri, against human colon (HT-29), lung (A-549), and melanoma (UACC-62) cancer cell lines, as well as against their non-malignant counterparts CCD-841 CoN, MRC-5, and VH-10, respectively, using the sulforhodamine B test. While compounds 1 and 3 were inactive, 2 presented strong activity with IC50 values between 0.12 and 0.92 μg mL(-1). The cytotoxicity mechanisms of 2 were investigated by cell cycle analysis and through DNA repair pathways, indicating that the compound is capable of arresting the cell cycle in the G0/G1 phase. This effect might be generated through damage to DNA by alkylation. In addition, compound 2 was able to decrease HT-29 migration.

  19. Methodology and application of surrogate plant PRA analysis to the Rancho Seco Power Plant: Final report

    SciTech Connect

    Gore, B.F.; Huenefeld, J.C.

    1987-07-01

    This report presents the development and the first application of generic probabilistic risk assessment (PRA) information for identifying systems and components important to public risk at nuclear power plants lacking plant-specific PRAs. A methodology is presented for using the results of PRAs for similar (surrogate) plants, along with plant-specific information about the plant of interest and the surrogate plants, to infer important failure modes for systems of the plant of interest. This methodology, and the rationale on which it is based, is presented in the context of its application to the Rancho Seco plant. The Rancho Seco plant has been analyzed using PRA information from two surrogate plants. This analysis has been used to guide development of considerable plant-specific information about Rancho Seco systems and components important to minimizing public risk, which is also presented herein.

  20. 1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum.

    PubMed

    Zhang, Jing-Jing; Yang, Xing-Wei; Liu, Xia; Ma, Jun-Zeng; Liao, Yang; Xu, Gang

    2015-12-24

    Hyperuralones C-H (1-6), six new 1,9-seco-bicyclic polyprenylated acylphloroglucinols (1,9-seco-BPAPs) derived from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core, together with six known analogues, were isolated from the aerial parts of Hypericum uralum. The structures of 1-6 were elucidated on the basis of the interpretation of NMR and MS spectroscopic data. The structure of attenuatumione B, a known compound isolated from H. attenuatum, was revised to that of a 1,9-seco-BPAP by NMR spectroscopic analysis and previous biomimetic synthesis methods. The inhibitory activities of these isolates on acetylcholinesterase were tested, and compounds 1 and 2 exhibited moderate activities with IC50 values of 9.6 and 7.1 μM, respectively. PMID:26583263

  1. An approach to seco-prezizaane sesquiterpenoids: enantioselective total synthesis of (+)-1S-minwanenone.

    PubMed

    Mehta, Goverdhan; Shinde, Harish M

    2012-09-21

    A strategy of general applicability toward seco-prezizaane sesquiterpenes, from a chiral, tricyclic synthon, readily available via an enzymatic resolution step from the Diels-Alder adduct of cyclopentadiene and p-benzoquinone, has been devised. Our approach enables harnessing of the stereochemical proclivities of the norbornyl system to install the desired stereochemistry at the key stereogenic centers. Recourse to an interesting stratagem to realign a stereochemical divergence into stereoreconvergence forms the cornerstone of our successful approach. The first total synthesis of (+)-1S-minwanenone, a prototypical member of seco-prezizaane subclass, has been accomplished. PMID:22897237

  2. The Connection Between Sediment Supply and Paired Strath Terrace Formation at Arroyo Seco, CA, USA.

    NASA Astrophysics Data System (ADS)

    Finnegan, N. J.

    2015-12-01

    Although wide, longitudinally traceable, paired strath terraces in river canyons are frequently argued to reflect periods of higher sediment supply, there is no consensus on how changes in sediment supply translate into dramatic changes in valley morphology. Here, quantitative analysis of LiDAR data is combined with field observations in Arroyo Seco, in the Santa Lucia Range of Central California, to develop a conceptual model for paired bedrock terrace formation and its connection to sediment supply. The most recently formed bedrock terrace in Arroyo Seco grades onto a prominent alluvial fan surface, suggesting that planation of straths in Arroyo Seco occurs as downstream alluvial fans aggrade. This aggradation apparently buffers Arroyo Seco's bedrock channel from base level fall on the Reliz Canyon Fault, which separates the bedrock and alluvial sections of the river. Notably, despite the fact that bedrock terraces grade smoothly onto alluvial fan surfaces, the deep aggradation of sediment downstream is not seen upstream in bedrock channel sections. Gravel on straths is typically only 0.5-1 m thick. Instead, excess gravel appears to be accommodated by the lateral planation of the wide strath itself. LiDAR evidence suggests that strath planation is associated with braiding, which is often triggered by increases in sediment supply. Given the high lateral mobility of braided streams and the extremely fractured (and hence easily detached) mudstone valley walls along Arroyo Seco, braiding provides a simple connection between sediment supply and lateral planation in Arroyo Seco. In Arroyo Seco, fan incision (under decreased sediment supply) should exhume a bedrock step whose height represents the accumulated fault slip during fan aggradation. The upstream propagation of this exhumed step as a knickpoint provides a simple mechanism to connect drops in sediment supply to rapid vertical incision, valley narrowing and strath terrace formation. Long profile data for Arroyo

  3. Acquisition of Seco Creek GIS database and it's use in water quality models

    SciTech Connect

    Steers, C.A.; Steiner, M.; Taylor, B. )

    1993-02-01

    The Seco Creek Water Quality Demonstration Project covers 1,700,670 acres in parts of Bandera, Frio, Medina and Uvalde Counties in south central Texas. The Seco Creek Database was constructed as part of the Soil Conservation Service's National Water Quality Program to develop hydrologic tools that measure the effects of agricultural nonpoint source pollution and to demonstrate the usefulness of GIS in natural resources management. This project will be part of a GRASS-Water Quality Model Interface which will incorporate watershed models with water quality planning and implementation by January of 1994. The Seco Creek Demonstration Area is the sole water supply for 1.3 million in the San Antonio Area. The database constructed for the project will help maintain the excellent water quality that flows directly into the Edwards Aquifer. The database consists of several vector and raster layers including: SSURGO quality soils, elevation, roads, streams and detailed data on field ownership, cropping and grazing practices and other landuses. This paper will consist of the development and planned uses of the Seco Creek Database.

  4. Geologic framework and hydrogeologic properties of the Seco Creek Watershed, Texas

    USGS Publications Warehouse

    Brown, D.S.; Mosier, John G.; Nalley, G.M.

    1999-01-01

    In 1991, the U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Agriculture (USDA) and the Texas State Soil and Water Conservation Board, began a study to evaluate the effects of agricultural best-management practices on surface- and ground-water quantity and quality in the Seco Creek watershed. The USGS study is part of a larger study known as the Seco Creek Water-Quality Demonstration Project, which is intended to demonstrate to urban and rural land and water users the potential to reduce transport of agricultural chemicals and sediment, improve groundwater and downstream surface-water quality, and improve the quality and abundance of vegetative cover. The Seco Creek watershed is approximately 50 miles (mi) west of San Antonio (fig. 1) and has a drainage area of approximately 255 square miles (mi2). Agricultural activities account for more than 99 percent of the land use in the watershed (Steffens and Wright, 1996). The purpose of this fact sheet is to describe the geologic framework and hydrogeologic properties of the Seco Creek watershed.

  5. New 3,4-seco-Grayanane Diterpenoids from the Flowers of Pieris japonica.

    PubMed

    Cao, Lang; Li, Yanping; Li, Hongmei; Liu, Dan; Li, Rongtao

    2016-01-01

    Three new 3,4-seco-grayanane diterpenoids, neopierisoids D-F (2-4), and a new natural one, neopierisoid C (1), were isolated from the flowers of Pieris japonica. Their structures were elucidated on the basis of extensive spectroscopic analysis, including one and two dimensional (1- and 2D)-NMR, as well as high resolution-electron ionization (HR-EI)-MS. PMID:27477663

  6. Helicopter Electromagnetic and Magnetic Survey Data and Maps, Seco Creek Area, Medina and Uvalade Counties, Texas

    USGS Publications Warehouse

    Smith, Bruce D.; Smith, David V.; Hill, Patricia L.; Labson, Victor F.

    2003-01-01

    A helicopter electromagnetic and magnetic (HEM) survey was completed of a 209 square kilometer (81 square miles) area of the central Edwards aquifer. This open-file report is a release of the airborne geophysical data and a summary of the hydrologic application. The survey area was centered on the Valdina Farms sinkhole along the Seco Creek drainage in western Medina County, Texas. Flight lines were flown north south with three east west tie lines to aid in leveling the magnetic data. Additional lines were flown on each side of the Seco and Little Seco Creek drainages. A five kilometer (4 mile) extension of 15 lines was flown north of the main survey block centered on Seco Creek. This digital data release contains the flight line data, grids, and maps of the HEM survey data. The Edwards aquifer in this area consists of three hydrologic zones: catchment, recharge, and confined. The Glen Rose Formation is exposed in the catchment area. The recharge zone is situated in the Balcones fault zone where the Devils River Group of the Edwards aquifer has been exposed by normal faults. The magnetic data is not discussed in depth here, but does have high amplitude closed anomalies caused by shallow igneous intrusives. The Woodard Cave Fault that separates the recharge and catchment zones is in places associated with a weak linear magnetic low. The HEM data has been processed to produce apparent resistivities for each of the six EM coil pairs and frequencies. Maps of the apparent resistivity for the five horizontal coil pairs show that the catchment, recharge, and confined zones all have numerous linear features that are likely caused by structures, many of which have not been mapped. The distribution of high resistivity areas reflects the lithologic differences within the Trinity and Edwards aquifers.

  7. Anoxic Androgen Degradation by the Denitrifying Bacterium Sterolibacterium denitrificans via the 2,3-seco Pathway

    PubMed Central

    Wang, Po-Hsiang; Yu, Chang-Ping; Lee, Tzong-Huei; Lin, Ching-Wen; Ismail, Wael; Wey, Shiaw-Pyng; Kuo, An-Ti

    2014-01-01

    The biodegradation of steroids is a crucial biochemical process mediated exclusively by bacteria. So far, information concerning the anoxic catabolic pathways of androgens is largely unknown, which has prevented many environmental investigations. In this work, we show that Sterolibacterium denitrificans DSMZ 13999 can anaerobically mineralize testosterone and some C19 androgens. By using a 13C-metabolomics approach and monitoring the sequential appearance of the intermediates, we demonstrated that S. denitrificans uses the 2,3-seco pathway to degrade testosterone under anoxic conditions. Furthermore, based on the identification of a C17 intermediate, we propose that the A-ring cleavage may be followed by the removal of a C2 side chain at C-5 of 17-hydroxy-1-oxo-2,3-seco-androstan-3-oic acid (the A-ring cleavage product) via retro-aldol reaction. The androgenic activities of the bacterial culture and the identified intermediates were assessed using the lacZ-based yeast androgen assay. The androgenic activity in the testosterone-grown S. denitrificans culture decreased significantly over time, indicating its ability to eliminate androgens. The A-ring cleavage intermediate (≤500 μM) did not exhibit androgenic activity, whereas the sterane-containing intermediates did. So far, only two androgen-degrading anaerobes (Sterolibacterium denitrificans DSMZ 13999 [a betaproteobacterium] and Steroidobacter denitrificans DSMZ 18526 [a gammaproteobacterium]) have been isolated and characterized, and both of them use the 2,3-seco pathway to anaerobically degrade androgens. The key intermediate 2,3-seco-androstan-3-oic acid can be used as a signature intermediate for culture-independent environmental investigations of anaerobic degradation of C19 androgens. PMID:24657867

  8. Ring-opening metathesis polymer sphere-supported seco-porphyrazines: efficient and recyclable photooxygenation catalysts.

    PubMed

    Fuchter, Matthew J; Hoffman, Brian M; Barrett, Anthony G M

    2006-01-20

    [reaction: see text] Crossover Linstead macrocyclization of norbornenyl-tagged diaminomaleonitrile with dipropylmaleonitrile gave the corresponding magnesium diaminohexapropylporphyrazine, which was subsequently converted into its zinc seco-derivative. Polymerization gave the corresponding ROMPgel and ROMPsphere (ROMP = ring-opening metathesis polymer) reagents, the latter of which proved efficient as an immobilized catalyst for the sensitized production of singlet oxygen for the purification-minimized parallel synthesis of endoperoxides and ene adducts. PMID:16408985

  9. Environmental radiological studies in 1989 near the Rancho Seco Nuclear Power Generating Station

    SciTech Connect

    Robison, W.L.; Wong, Kai M.; Jones, H.E.

    1990-11-01

    In December 1988, the Sacramento Municipal Utilities District (SMUD) asked the Lawrence Livermore National Laboratory's (LLNL) Environmental Sciences Division (ENV) to collect sediment, water,and fish samples downstream from the Rancho Seco Nuclear Power Generating Station for analysis of radionuclides to compare with results from earlier surveys in 1984 through 1987 (1--8). ENV was, however, asked to reduce the total number of sample collections to a minimum in this study because of financial constraints. The proposal ENV submitted for the 1989 Environmental Radiological Studies downstream of the Rancho Seco Nuclear Power Generating Station reflected this reduction, but we believe, nevertheless, the 1989 efforts do allow us to make some meaningful comparisons with the previous studies. Cesium-137 is the most significant radionuclide still observed downstream from the Rancho Seco Nuclear Power Plant. Only occasionally is {sup 134}Cs or {sup 60}CO observed. In 1989, the concentration of {sup 137}Cs in the water and fish decreased with distance from the plant to the same level that is was in 1987, and was lower than it had been from 1984 through 1986. The concentration ratio (CR) for {sup 137}Cs in fish is between 1000 and 1500, which is below the NRC default value of 2000. Physical mixing in the creek environment has moved the {sup 137}Cs deeper into the sediment column, thereby reducing the concentration in the top 12 cm relative to that in previous years. 8 refs., 18 figs., 9 tabs.

  10. Expedient preparative isolation and tandem mass spectrometric characterization of C-seco triterpenoids from Neem oil.

    PubMed

    Haldar, Saikat; Mulani, Fayaj A; Aarthy, Thiagarayaselvam; Dandekar, Devdutta S; Thulasiram, Hirekodathakallu V

    2014-10-31

    C-seco triterpenoids are widely bioactive class of natural products with high structural complexity and diversity. The preparative isolation of these molecules with high purity is greatly desirable, although restricted due to the complexity of natural extracts. In this article we have demonstrated a Medium Pressure Liquid Chromatography (MPLC) based protocol for the isolation of eight major C-seco triterpenoids of salannin skeleton from Neem (Azadirachta indica) oil. Successive application of normal phase pre-packed silica-gel columns for the fractionation followed by reverse phase in automated MPLC system expedited the process and furnished highly pure metabolites. Furthermore, eight isolated triterpenoids along with five semi-synthesized derivatives were characterized using ultra performance liquid chromatography-electrospray ionization-quadrupole/orbitrap-MS/MS spectrometry as a rapid and sensitive identification technique. The structure-fragment relationships were established on the basis of plausible mechanistic pathway for the generation of daughter ions. The MS/MS spectral information of the triterpenoids was further utilized for the identification of studied molecules in the complex extract of stem and bark tissues from Neem.

  11. RP-HPLC analysis of seco-iridoid glycoside swertiamarin from different Swertia species.

    PubMed

    Kshirsagar, Parthraj R; Pai, Sandeep R; Nimbalkar, Mansingraj S; Gaikwad, Nikhil B

    2016-01-01

    Genus Swertia is valued for its great medicinal potential; mainly Swertia chirayita (Roxb. ex Fleming) H. Karst. is used in traditional medicine for a wide range of diseases. Seco-iridoid glycosides like swertiamarin is referred with enormous pharmacological potentials. The aim of the study was to identify a suitable substitute to S. chirayita by quantifying seco-iridoid swertiamarin from five different Swertia species endemic to the Western Ghats. The reverse-phase high-performance liquid chromatography diode array detector analyses were performed and chromatographic separation was achieved on a Lichrospher 100, C18e (5 µm) column (250-4.6 mm). A mobile phase consisting of acetonitrile and water (25:75) was used for separation. Results indicated that the concentration of the marker compound has been found to vary largely between and within the species from different localities. The content of swertiamarin was the highest in S. chirayita compared to the other species studied herein, advocating the use of Swertia minor as an alternate source to S. chirayita. PMID:26299409

  12. Managing the Arroyo Seco for Flood Prevention, Erosion Control, Waterway and Habitat Restoration

    SciTech Connect

    Sanchez, L; Wang, C; Laurant, J

    2003-02-06

    One of the most important tasks for a site facility manager is to ensure that appropriate channel erosion controls are applied to on-site drainage channels. These erosion controls must minimize risks to the public and structures. Water and sediment loads commonly originate from off-site sources and many of the traditional reactionary measures (installing rip-rap or some other form of bed or bank armor) simply transfer or delay the problem. State and federal agency requirements further complicate the management solution. One case in point is the Arroyo Seco, an intermittent stream that runs along the southwest corner of the Lawrence Livermore National Laboratory (LLNL) in Livermore, California. In 2001, LLNL contracted Questa Engineering Corporation to conduct hydraulic, geomorphic, and biological investigations and to prepare an alternatives and constraints analysis. From these investigations, LLNL has selected a water management plan that encompasses overall flood prevention, erosion control, and waterway and habitat restoration and enhancement elements. The most unique aspect of the Arroyo Seco management plan is its use of non-traditional and biotechnical techniques.

  13. Expedient preparative isolation and tandem mass spectrometric characterization of C-seco triterpenoids from Neem oil.

    PubMed

    Haldar, Saikat; Mulani, Fayaj A; Aarthy, Thiagarayaselvam; Dandekar, Devdutta S; Thulasiram, Hirekodathakallu V

    2014-10-31

    C-seco triterpenoids are widely bioactive class of natural products with high structural complexity and diversity. The preparative isolation of these molecules with high purity is greatly desirable, although restricted due to the complexity of natural extracts. In this article we have demonstrated a Medium Pressure Liquid Chromatography (MPLC) based protocol for the isolation of eight major C-seco triterpenoids of salannin skeleton from Neem (Azadirachta indica) oil. Successive application of normal phase pre-packed silica-gel columns for the fractionation followed by reverse phase in automated MPLC system expedited the process and furnished highly pure metabolites. Furthermore, eight isolated triterpenoids along with five semi-synthesized derivatives were characterized using ultra performance liquid chromatography-electrospray ionization-quadrupole/orbitrap-MS/MS spectrometry as a rapid and sensitive identification technique. The structure-fragment relationships were established on the basis of plausible mechanistic pathway for the generation of daughter ions. The MS/MS spectral information of the triterpenoids was further utilized for the identification of studied molecules in the complex extract of stem and bark tissues from Neem. PMID:25267707

  14. Structure-activity relationships of seco-prezizaane and picrotoxane/picrodendrane terpenoids by Quasar receptor-surface modeling.

    PubMed

    Schmidt, Thomas J; Gurrath, Marion; Ozoe, Yoshihisa

    2004-08-01

    The seco-prezizaane-type sesquiterpenes pseudoanisatin and parviflorolide from Illicium are noncompetitive antagonists at housefly (Musca domestica) gamma-aminobutyric acid (GABA) receptors. They show selectivity toward the insect receptor and thus represent new leads toward selective insecticides. Based on the binding data for 13 seco-prezizaane terpenoids and 17 picrotoxane and picrodendrane-type terpenoids to housefly and rat GABA receptors, a QSAR study was conducted by quasi-atomistic receptor-surface modeling (Quasar). The resulting models provide insight into the structural basis of selectivity and properties of the binding sites at GABA receptor-coupled chloride channels of insects and mammals.

  15. Croton insularis introduces the seco-casbane class with EBC-329 and the first casbane endoperoxide EBC-324.

    PubMed

    Maslovskaya, Lidiya A; Savchenko, Andrei I; Krenske, Elizabeth H; Gordon, Victoria A; Reddell, Paul W; Pierce, Carly J; Parsons, Peter G; Williams, Craig M

    2014-10-21

    Investigation of Croton insularis afforded the first in class seco-casbane diterpene, EBC-329. A highly oxidised casbane, EBC-324, was also isolated. The structural motif within EBC-324, which consists of an epoxidised hemi-acetal endoperoxide, is new to the casbane family.

  16. Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.

    PubMed

    Jiang, Hua-Yi; Wang, Wei-Guang; Zhou, Min; Wu, Hai-Yan; Zhan, Rui; Li, Xiao-Nian; Du, Xue; Li, Yan; Pu, Jian-Xin; Sun, Han-Dong

    2013-11-22

    Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M-S, 1-7) and seven known compounds (8-14), were isolated from the aerial parts of Isodon sculponeatus . Compound 1 is the first example of an ent-kauranoid, possessing a 11,12-epoxy group, and compounds 6 and 7 have a rare 3,6-epoxy group. The structures were established primarily by NMR and MS methods, and the absolute configurations of 1, 3, and 6 were determined by single-crystal X-ray diffraction. Compound 14 showed significant cytotoxic activity against five human tumor lines, with IC50 values ranging from 1.0 to 3.5 μM, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 2.2 μM. PMID:24219809

  17. Environmental radiological studies downstream from Rancho Seco Nuclear Power Generating Station

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Dawson, J.W.; Brunk, J.L.; Jokela, T.A.

    1985-03-22

    This report summarizes the information compiled in 1984 while assessing the environmental impact of radionuclides in aquatic releases from the Rancho Seco Nuclear Power Generating Station. Gamma-emitting radionuclides discharged since 1981 are found in many of the dietary components derived from the creeks receiving the effluent wastewater. Some soils and crops are found to contain radionuclides that originate from the contaminated water that was transferred to land during the irrigation season. /sup 134/Cs and /sup 137/Cs are the primary gamma-emitting radionuclides detected in the edible flesh of fish from the creeks. Concentrations in the flesh of fish decreased exponentially with distance from the plant. No significant differences in the /sup 137/Cs activity were found between male and female fish of equal size, but concentrations may vary in fish of different size, with the season and diet. 21% of the total /sup 137/Cs and /sup 134/Cs discharged between 1981 and 1984 is associated with the creek sediments to a distance of 27 km from the plant. Fractions of the missing inventory have been transferred to land during the irrigation season or to downstream regions more distant than 27 km from the plant. The radiocesium content of the sediments in 1984 decreased significantly in a downstream direction, much in the same manner as concentrations decreased in fish. Radioactivity originating from the plant was not above detection limits in any terrestrial food item sampled beyond 6.5 km from the plant. Based on the usage factors provided by individuals interviewed in a 1984 survey, the fish and aquatic-organism ingestion pathway contributed the largest radiological dose to humans utilizing products contaminated with the radionuclides in the liquid wastes discharged from the Rancho Seco Nuclear Power Generating Station in 1984.

  18. La Irradiación de alimentos: Lo que usted debe saber

    Center for Food Safety and Applied Nutrition (CFSAN)

    La irradiaciÃÆ'ƒÂ³n de alimentos (la aplicaciÃÆ'Æ’ ³n de radiaciÃÆ'ƒÂ³n ionizante a los alimentos ...

  19. seco-Briarellinone and Briarellin S, Two New Eunicellin-Based Diterpenoids from the Panamanian Octocoral Briareum asbestinum

    PubMed Central

    Gómez-Reyes, José Félix; Salazar, Ana; Guzmán, Héctor M.; González, Yisett; Fernández, Patricia L.; Ariza-Castolo, Armando; Gutiérrez, Marcelino

    2012-01-01

    Two new eunicellin-based diterpenes, seco-briarellinone (1) and briarellin S (2), and a known seco-asbestinin (3) have been isolated from the methanolic extract of the common octocoral Briareum asbestinum collected in Bocas del Toro, Caribbean of Panama. The structures and relative stereochemistry of the compounds were defined using extensive spectroscopic analysis including 1D, 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). compounds 1 and 2 displayed anti-inflammatory properties inhibiting nitric oxide (NO) production induced by lipopolisacharide (LPS) in macrophages with an Inhibitory concentration 50% (IC50) of 4.7 μM and 20.3 μM, respectively. This is the first report of briarellin diterpenes containing a ketone group at C-12. PMID:23203281

  20. seco-Briarellinone and briarellin S, two new eunicellin-based diterpenoids from the Panamanian octocoral Briareum asbestinum.

    PubMed

    Gómez-Reyes, José Félix; Salazar, Ana; Guzmán, Héctor M; González, Yisett; Fernández, Patricia L; Ariza-Castolo, Armando; Gutiérrez, Marcelino

    2012-11-01

    Two new eunicellin-based diterpenes, seco-briarellinone (1) and briarellin S (2), and a known seco-asbestinin (3) have been isolated from the methanolic extract of the common octocoral Briareum asbestinum collected in Bocas del Toro, Caribbean of Panama. The structures and relative stereochemistry of the compounds were defined using extensive spectroscopic analysis including 1D, 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Compounds 1 and 2 displayed anti-inflammatory properties inhibiting nitric oxide (NO) production induced by lipopolisacharide (LPS) in macrophages with an Inhibitory concentration 50% (IC₅₀) of 4.7 μM and 20.3 μM, respectively. This is the first report of briarellin diterpenes containing a ketone group at C-12. PMID:23203281

  1. Seco-limonoid derived from Raputia heptaphylla promotes the control of cutaneous leishmaniasis in hamsters (Mesocricetus auratus).

    PubMed

    Granados-Falla, Diana; Gomez-Galindo, Angela; Daza, Alejandro; Robledo, Sara; Coy-Barrera, Carlos; Cuca, Luis; Delgado, Gabriela

    2016-03-01

    The rational search of novel bioactive molecules against pathogens with immunomodulatory activity is presently one of the most significant approaches to discover and design new therapeutic agents for effective control of infectious diseases, such as the infection caused by Leishmania parasites. In the present study, we evaluated the therapeutic efficacy of the recently characterized immunomodulatory compound 11α,19β-dihydroxy-7-acetoxy-7-deoxoichangin, a seco-limonoid derived from the bark of Raputia heptaphylla (Pittier) using: (1) peritoneal macrophages and (2) Mesocricetus auratus hamsters infected with Leishmania (V.) panamensis and Leishmania (L.) amazonensis. We observed the ability of this seco-limonoid to induce the effective control of the parasite either in vitro [determining an effective concentration 50 (EC50) of 59 µ m at the infection model] and in vivo (inducing clinical improvement or even cure in infected animals treated compared with the groups of animals treated with vehicle solution or meglumine antimoniate). PMID:26694129

  2. Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues.

    PubMed

    Chen, Ying; Cheng, Ming; Liu, Fa-Qiang; Xia, Peng; Qian, Keduo; Yu, Donglei; Xia, Yi; Yang, Zheng-Yu; Chen, Chin-Ho; Morris-Natschke, Susan L; Lee, Kuo-Hsiung

    2011-10-01

    In a continuing study of novel anti-HIV agents with drug-like structures and properties, 30 1'-O-, 1'-S-, 4'-O- and 4'-substituted-2',3'-seco-3'-nor DCP and DCK analogues (8-37) were designed and synthesized. All newly synthesized seco-compounds were screened against HIV-1(NL4-3) and a multiple reverse transcriptase (RT) inhibitor-resistant (RTMDR) strain in the TZM-bl cell line, using seco-DCK (7) and 2-ethyl-DCP (4) as controls. Several compounds (14, 18, 19, 22-24, and 32) exhibited potent anti-HIV activity with EC(50) values ranging from 0.93 to 1.93 μM and therapeutic index (TI) values ranging from 20 to 39. 1'-O-Isopropoxy-2',3'-seco-3'-nor-DCP (12) showed the greatest potency among the newly synthesized compounds with EC(50) values of 0.47 and 0.88 μM, and TI of 96 and 51, respectively, against HIV-1(NL4-3) and RTMDR strains. The seco-compounds exhibited better chemical stability in acidic conditions compared with DCP and DCK compounds. Overall, the results suggested that seco-DCP analogues with simplified structures may be more favorable for development as novel anti-HIV candidates.

  3. Quaternary geologic map of the north-central part of the Salinas River Valley and Arroyo Seco, Monterey County, California

    USGS Publications Warehouse

    Taylor, Emily M.; Sweetkind, Donald S.

    2014-01-01

    Arroyo Seco, a perennial drainage in the central Coast Range of California, records a sequence of strath terraces. These terraces preserve an erosional and depositional history, controlled by both climate change and regional tectonics. These deposits have been mapped and correlated on the basis of field investigations, digital terrain analysis, stream gradient profiles, evaluation of published regional soil maps, and satellite imagery. Seven of the strath terraces and associated alluvial fans have been dated by optically stimulated luminescence (OSL) or infrared stimulated luminescence (IRSL). The OSL and IRSL dates on seven of the strath terraces and associated alluvial fans in Arroyo Seco are approximately >120 ka, >65 ka, 51–46 ka, 36–35 ka, 9 ka, and 2–1 ka. These dates generally fall within the range of ages reported from many well-dated marine terraces on the California coast that are formed during sea-level high stands. Tectonic movements, consistently upward, result in a constantly and slowly emerging coastline, however, the regional effects of climate change and resulting eustatic sea-level rises are interpreted as the driving mechanism for erosion and aggradation in Arroyo Seco.

  4. Concentration of radionuclides in fresh water fish downstream of Rancho Seco Nuclear Generating Plant

    SciTech Connect

    Noshkin, V.E.; Eagle, R.J.; Dawson, J.M.; Brunk, J.L.; Wong, X.M.

    1984-12-27

    Fish were collected for radionuclide analysis over a 5-month period in 1984 from creeks downstream of the Rancho Seco Nuclear Generating Plant, which has been discharging quantities of some fission and activation products to the waterway since 1981. Among the fish, the bluegill was selected for intensive study because it is very territorial and the radionuclide concentrations detected should be representative of the levels in the local environment at the downstream locations sampled. Among the gamma-emitting radionuclides routinely released, only /sup 134/Cs and /sup 137/Cs were detected in the edible flesh of fish. Concentrations in the flesh of fish decreased with distance from the plant. The relationship between concentration and distance was determined to be exponential. Exponential equations were generated to estimate concentrations in fish at downstream locations where no site-specific information was available. Mean concentrations of /sup 137/Cs in bluegill collected during April, May, July and August from specific downstream stations were not significantly different in spite of the release of 131 mCi to the creeks between April and August. The concentrations in fish are not responding to changes in water concentrations brought about by plant discharges. Diet appears to be a more significant factor than size or weight or water concentration in regulating body burdens of /sup 137/Cs in these fish.

  5. Environmental radiological studies downstream from the Rancho Seco Nuclear Power Generating Station, 1985

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Brunk, J.L.; Jokela, T.A.

    1986-02-06

    Information compiled in 1985 while assessing the environmental impact of radionuclides previously discharged with aqueous releases from the Rancho Seco Nuclear Power Generating Plant is presented. In October 1984, the quantities of gamma-emitting radionuclides in water discharged to Clay Creek from the plant were reduced below operationally defined detection limits for liquid effluents. However, radionuclides previously discharged persist in the downstream environment and are found in many aquatic dietary components. /sup 134/Cs and /sup 137/Cs are the primary gamma-emitting radionuclides detected in the edible flesh of different fish, crayfish, and frogs. Coefficients for exponential equations are generated, from a least square analysis, that relate the change in concentration of /sup 137/Cs in fish to distance downstream and time between March and October 1985. Concentrations of /sup 137/Cs in surface creek sediments also decreased in the downstream direction much in the same manner as concentrations decreased in fish. However, there was no significant difference in the radiocesium concentrations in surface sediements collected from comparable locations during both 1984 and 1985.

  6. Vegetation and climate history from Laguna de Río Seco, Sierra Nevada, southern Spain

    NASA Astrophysics Data System (ADS)

    Anderson, R. S.; Jimenez-Moreno, G.

    2010-12-01

    The largest mountain range in southern Spain - the Sierra Nevada - is an immense landscape with a rich biological and cultural heritage. Rising to 3,479 m at the summit of Mulhacén, the range was extensively glaciated during the late Pleistocene. Subsequent melting of cirque glaciers allowed formation of numerous small lakes and wetlands. One south-facing basin contains Laguna de Río Seco, a small lake at ca. 3020 m elevation, presently above potential treeline. Pollen analysis of sediment cores documents over 11,000 calendar years of vegetation change there. The early record, to ca. 5,700 cal yr BP, is dominated by pine pollen, with birch, deciduous oak, and grass, with an understory of shrubs types. Pine trees probably never grew at the elevation of the lake, but aquatic microfossils indicate lake levels were highest prior to ca. 7,800 cal yr BP, perhaps as a result of heavy winter precipitation, and early Holocene expansion of the ITCZ. Drier conditions commenced by 5,700 cal yr BP, shown by declines in wetland pollen, and increases in high elevation steppe shrubs more common today (juniper, sage, and others). The local and regional impact of humans increased substantially after ca. 2700 years ago, with the regional loss of pine forest or woodland, increases in pollen and spore types associated with pasturing, and olive cultivation at lower elevations.

  7. Novel 3,4-seco bile acid diamides as selective anticancer proliferation and migration agents.

    PubMed

    Mao, Shi-Wei; Chen, Huang; Yu, Li-Fang; Lv, Fang; Xing, Ya-Jing; Liu, Ting; Xie, Jia; Tang, Jie; Yi, Zhengfang; Yang, Fan

    2016-10-21

    A series of new seco-A ring bile acid diamides were synthesized, and their antiproliferative activities against PC3M (prostate), HT29 (colon) and ES-2 (ovarian) cancer cell lines were investigated using SRB assays. Most synthesized compounds presented improved antiproliferative activities compared to the parent bile acids (IC50 > 80 μM), especially the piperazine conjugated compound 27 with IC50 values of 1.07, 4.58 and 3.86 μM against PC3M, HT29 and ES-2 cancer cell lines, respectively. In addition, all the tested compounds showed less cytotoxic activity on a noncancerous cell line (HAF), and the most active compound 27 exhibited the highest selectivity (Selectivity Index, SI(PC3M) = 26.3). Furthermore, 27 could also enhance G1 arrest in PC3M cell, revealed by cell cycle analysis, and increase anti-migration activity on PC3M cells, confirmed by transwell migration assay. PMID:27448915

  8. Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity.

    PubMed

    Farimani, Mahdi Moridi; Abbas-Mohammadi, Mahdi; Esmaeili, Mohammad-Ali; Salehi, Peyman; Nejad-Ebrahimi, Samad; Sonboli, Ali; Hamburger, Matthias

    2015-09-01

    Fractionation of an acetone extract of the aerial parts of Salvia urmiensis led to the isolation of a new (1) and a known (2) E-seco-ursane-type triterpenoid, together with four other known compounds. Their structures were established by 1D and 2D nuclear magnetic resonance as well as high-resolution electrospray ionization mass spectrometry. The effect of compounds 1 and 2 on cell viability of HeLa and HepG2 cells was investigated with the MTT assay. We also report the mechanism of action of compound 2 as a potential anticancer agent in HeLa cells. Bcl-2, Bax, and caspases signaling pathway expression in HeLa cells was analyzed. HeLa cells treated with compound 2 were assayed for the cleavage of poly-(ADP-ribose)-polymerase and DNA fragmentation resulting in nuclear shrinkage. Taken together, these results suggest that treatment of HeLa cells with compound 2 can induce apoptosis by regulating Bcl-2 family members and by suppressing caspase cascade activation. PMID:26252828

  9. A Fractal Interpretation of Controlled-Source Helicopter Electromagnetic Survey Data: Seco Creek, Edwards Aquifer, TX

    NASA Astrophysics Data System (ADS)

    Decker, K. T.; Everett, M. E.

    2009-12-01

    The Edwards aquifer lies in the structurally complex Balcones fault zone and supplies water to the growing city of San Antonio. To ensure that future demands for water are met, the hydrological and geophysical properties of the aquifer must be well-understood. In most settings, fracture lengths and displacements occur in power-law distributions. Fracture distribution plays an important role in determining electrical and hydraulic current flowpaths. 1-D synthetic models of the controlled-source electromagnetic (CSEM) response for layered models with a fractured layer at depth described by the roughness parameter βV, such that 0≤βV<1, associated with the power-law length-scale dependence of electrical conductivity are developed. A value of βV = 0 represents homogeneous, continuous media, while a value of 0<βV<1 shows that roughness exists. The Seco Creek frequency-domain helicopter electromagnetic survey data set is analyzed by introducing the similarly defined roughness parameter βH to detect lateral roughness along survey lines. Fourier transforming the apparent resistivity as a function of position along flight line into wavenumber domain using a 256-point sliding window gives the power spectral density (PSD) plot for each line. The value of βH is the slope of the least squares regression for the PSD in each 256-point window. Changes in βH with distance along the flight line are plotted. Large values of βH are found near well-known large fractures and maps of βH produced by interpolating values of βH along survey lines suggest previously undetected structure at depth.

  10. Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.

    PubMed

    Pati, Hari; Howard, Tiffany; Townes, Heather; Lingerfelt, Brian; McNulty, LuAnne; Lee, Moses

    2004-01-01

    Analogs of the seco-cyclopyrroloindoline (seco-CPI), the DNA alkylation pharmacophore of CC-1065 and the duocarmycins, can be prepared through a 5-exo-trig radical cyclization of a free radical and a 3-chloro-2-allylic moiety. This manuscript reports an unexpected discovery that, depending on the structure and stability of the free radical, the cyclization process leads to the production of an appreciable amount of seco- cyclopropyltetrahydroquinolines 7a-d along with the seco-cyclopropoyltetra- hydroindoline products (6a-e). For instance, free radical reaction of the bromoallylic chloride 5a produced an equal amount of 6-benzyloxy-N-t-butoxycarbonyl-3- (chloromethyl)furano[e]indoline (6a), and 7-benzyloxy-N-t-butoxycarbonyl-3-chloro- 1,2,3,4-tetrahydrofurano[f]quinoline (7a). Three other examples that produced mixtures of indoline and quinoline products are provided. In only one of the examples reported in this manuscript, the 6-benzyloxy-N-t-butoxycarbonyl-3-(chloromethyl)benzo[e]indoline, was a seco-CBI precursor 6e formed exclusively, consistent with literature precedents. PMID:18007417

  11. Environmental radiological studies conducted during 1986 in the vicinity of the Rancho Seco Nuclear Power Generating Station

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Brunk, J.L.; Jokela, T.A.

    1987-03-01

    This report summarizes the information compiled in 1986 for our assessment of the environmental impact of radionuclides discharged with aqueous releases from the Rancho Seco Nuclear Power Generating Plant. In October 1984, a liquid-effluent control program was initiated that significantly reduced the quantities of radionuclides discharged with liquid waste from the plant. However, results from our sampling program in 1986 indicate that previously discharged radionuclides persist in the downstream environment and are found in many aquatic dietary components although at concentrations much lower than those measured in 1984 and 1985. The greatly reduced activities in the dietary components from the aquatic environment attest to the effectiveness of the liquid-effluent control program. Concentrations in the flesh of fish from the creeks have decreased over time and with distance from the plant outfall. The mean concentration of /sup 137/Cs in fish collected from Laguna Creek at locations more than 7.5 km from Rancho Seco is now comparable to the concentration determined in fresh-water fish randomly selected from Chicago, Illinois, markets. By August 1986, the mean concentration of /sup 137/Cs in the flesh of bluegill had fallen to 7% of the concentration measured in fish from comparable locations in 1984 and was 30% of the mean concentration measured in these fish during August 1985. Stable potassium in the water plays a major role in the accumulation of /sup 137/Cs by fish. Concentrations of /sup 137/Cs in the surface sections of creek sediments also declined between the end of 1984 and 1986 with an effective half-life of approximately 2 y. Surface soils collected around a perimeter 11 km from Rancho Seco and from ranchlands closer to the plant showed only concentrations of /sup 137/Cs originating from global fallout. Soils previously irrigated with Clay Creek water retain levels of both /sup 134/Cs and /sup 137/Cs.

  12. Shallow Structure of the Eagle Rock and Raymond Faults in Arroyo Seco, Los Angeles County, California

    NASA Astrophysics Data System (ADS)

    Scheirer, D. S.; Rymer, M. J.; Catchings, R. D.; Goldman, M.; Fuis, G.

    2012-12-01

    To understand the location, dip, and possible structural connection of the Eagle Rock and Raymond faults in Pasadena and South Pasadena, California, we acquired and analyzed high-resolution seismic reflection and refraction data, as well as gravity observations, along the floor of the Arroyo Seco. The studies were conducted to aid in understanding the seismic hazards of these faults in this urban setting. Seismic reflection and refraction data, including both P-wave and S-wave records, were collected along two profiles, a 1.2-km-long northern profile crossing the Eagle Rock fault, and a 450-m-long southern profile crossing the Raymond fault. Seismic sources were Betsy-Seisgun shots, accelerated weight drops, and repeated sledge-hammer impacts, which were recorded on multi-channel seismograph systems connected to vertical- and horizontal-component geophones spaced at a 5-m interval. Gravity data were collected along a single ~3-km-long profile coincident with and extending beyond and between the two seismic profiles, with stations spaced every 25-m near the fault traces and at greater intervals farther from the fault traces. We carefully accounted for the gravity effects of the adjacent concrete drainage channel and of the walls of the arroyo, to generate gravity anomalies that reflect sub-surface density contrasts across the Eagle Rock and Raymond faults. Seismic reflection image quality is compromised by the highly-deformed Miocene strata offset by these faults. However, reflection and especially refraction results indicate that both the Eagle Rock and Raymond faults consist of multiple, steeply-north-dipping fault strands. P- and S-wave seismic tomography results of the uppermost 50-100 m yield velocity variations that can be converted to probable density variations, and thus be included in the gravity anomaly analysis. The gravity anomalies predicted from the velocity variations account for less than one-third of the anomalies observed across the faults

  13. SECO sub 2 (stored energy in CO sub 2 ); Retrofit CO sub 2 bottoming cycles with off-peak energy storage for existing combustion turbines

    SciTech Connect

    Andrepont, J.S. ); Kooy, R.J. ); Combs, R.T. )

    1988-01-01

    The SECO{sub 2} Power energy storage system is analyzed as a retrofit bottoming cycle for existing Virginia Power combustion turbines (CT's). The closed-loop SECO{sub 2} power system produces on-peak energy using a CO{sub 2} Rankine cycle which rejects heat to {minus} 70{degrees}F stored CO{sub 2} triple point solid; off-peak energy later regenerates the solid. Inherent advantages of the system are shown to be compact storage, minimal environmental impact, and dry-cooled capability, all of which contribute to flexibility in siting and rapid licensing/construction schedules.

  14. Decandrinin, an unprecedented C9-spiro-fused 7,8-seco-ent-abietane from the Godavari mangrove Ceriops decandra.

    PubMed

    Wang, Hui; Li, Min-Yi; Katele, Félix Zongwe; Satyanandamurty, Tirumani; Wu, Jun; Bringmann, Gerhard

    2014-01-01

    Decandrinin (1), an unprecedented C9-spiro-fused 7,8-seco-ent-abietane, was obtained from the bark of an Indian mangrove, Ceriops decandra, collected in the estuary of Godavari, Andhra Pradesh. The constitution and the relative configuration of 1 were determined by HRMS (ESI) and extensive NMR investigations, and the absolute configuration by circular dichroism (CD) and optical-rotatory dispersion (ORD) spectroscopy in combination with quantum-chemical calculations. Decandrinin is the first 7,8-seco-ent-abietane.

  15. A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.

    PubMed

    Kupchinsky, Stanley; Centioni, Sara; Howard, Tiffany; Trzupek, John; Roller, Shane; Carnahan, Virginia; Townes, Heather; Purnell, Bethany; Price, Carly; Handl, Heather; Summerville, Kaitlin; Johnson, Kimberly; Toth, James; Hudson, Stephen; Kiakos, Konstantinos; Hartley, John A; Lee, Moses

    2004-12-01

    The synthesis, DNA binding properties, and in vitro and in vivo anticancer activity of fifteen achiral seco-cyclopropylindoline (or achiral seco-CI) analogs (5a-o) of CC-1065 and the duocarmycins are described. The achiral seco-CI analogs contain a 4-hydroxyphenethyl halide moiety that is attached to a wide range of indole, benzimidazole, pyrrole, and pyridyl-containing noncovalent binding components. The 4-hydroxyphenethyl halide moiety represents the simplest mimic of the seco-cyclopropylpyrroloindoline (seco-CPI) pharmacophore found in the natural products, and it lacks a chiral center. The sequence and minor groove specificity of the achiral compounds was ascertained using a Taq DNA polymerase stop assay and a thermal induced DNA cleavage experiment using either a fragment of pBR322 or pUC18 plasmid DNA. For example, seco-CI-InBf (5a) and seco-CI-TMI (5c) demonstrated specificity for AT-rich sequences, particularly by reacting with the underlined adenine-N3 position of 5'-AAAAA(865)-3'. This is also the sequence that CC-1065 and adozelesin prefer to alkylate. The achiral seco-CI compounds were subjected to cytotoxicity studies against several human (K562, LS174T, PC3, and MCF-7) and murine cancer cell lines (L1210 and P815). Following continuous drug exposure, the achiral compounds were found to be cytotoxic, with IC(50) values in the muM range. Interestingly, the carbamate protected compound 5p was significantly less cytotoxic than agent 5c, supporting the hypothesis that loss of HCl and formation of a spiro[2,5]cyclopropylcyclohexadienone intermediate is necessary for biological activity. The achiral seco-CI compounds 5a and 5c were submitted to the National Cancer Institute for further cytotoxicity screening against a panel of 60 different human cancer cell lines. Both compounds showed significant activity, particularly against several solid tumor cell lines. Flow cytometry studies of P815 cells that were incubated with compound 5c at its IC(50

  16. Brine shrimp lethality test active constituents and new highly oxygenated seco-prezizaane-type sesquiterpenes from Illicium merrillianum.

    PubMed

    Huang, Jian-Mei; Nakade, Kousuke; Kondo, Mamiko; Yang, Chun-Shu; Fukuyama, Yoshiyasu

    2002-01-01

    In the study of bioactive substances in Illicium plants, the methanol extract of I. merrillianum showed brine shrimp lethality test (BST) activity at 200 microg/ml. Bioassay-guided fractionation of the BST active fractions resulted in the isolation of 4-O-methyleudesm-11-en-4alpha-ol, eudesmol-11-en-4alpha-ol and (-)-hinokinin as potent BST active compounds. On the other hand, four new highly oxygenated seco-prezizaane-type sesquiterpenes, merrilliortholactone (1), 2alpha-hydroxycycloparvifloralone (2), 2alpha-hydroxycycloparviflorolide (3), and 2alpha-hydroxyanisatin (4) were isolated from the BST-inactive polar fractions. The structures of new compounds were elucidated by extensive analyses of spectral data. Furthermore, the absolute configuration of 3 was established by the modified Mosher's method. Compounds 1--4 showed neither BST activity at 100 microg/ml nor neurite outgrowth-promoting activity. PMID:11824575

  17. Dose to man from a hypothetical loss-of-coolant accident at the Rancho Seco Nuclear Power Plant

    SciTech Connect

    Peterson, K.R.; Greenly, G.D.

    1981-02-01

    At the request of the Sacramento Municipal Utilities District, we used our computer codes, MATHEW and ADPIC, to assess the environmental impact of a loss-of-coolant accident at the Rancho Seco Nuclear Power Plant, about 40 kilometres southeast of Sacramento, California. Meteorological input was selected so that the effluent released by the accident would be transported over the Sacramento metropolitan area. With the release rates provided by the Sacramento Municipal Utilities District, we calculated the largest total dose for a 24-hour release as 70 rem about one kilometre northwest of the reactor. The largest total dose in the Sacramento metropolitan area is 780 millirem. Both doses are from iodine-131, via the forage-cow-milk pathway to an infant's thyroid. The largest dose near the nuclear plant can be minimized by replacing contaminated milk and by giving the cows dry feed. To our knowledge, there are no milk cows within the Sacramento metropolitan area.

  18. Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

    PubMed Central

    Correa, Hebelin; Aristizabal, Fabio; Duque, Carmenza; Kerr, Russell

    2011-01-01

    To expand the potential of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia islands (southwest Caribbean Sea), we report the anti-microbial profile against four pathogenic microorganisms (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans) and report a more complete cytotoxic profile against five human cells lines (HeLa, PC-3, HCT116, MCF-7 and BJ) for the compounds PsG, PsP, PsQ, PsS, PsT, PsU, 3-O-acetyl-PsU, seco-PsJ, seco-PsK and IMNGD. For the cytotoxic profiles, all compounds evaluated showed moderate and non-selective activity against both tumor and normal cell lines, where PsQ and PsG were the most active compounds (GI50 values between 5.8 μM to 12.0 μM). With respect to their anti-microbial activity the compounds showed good and selective activity against the Gram-positive bacteria, while they did not show activity against the Gram-negative bacterium or yeast. PsU, PsQ, PsS, seco-PsK and PsG were the most active compounds (IC50 2.9–4.5 μM) against S. aureus and PsG, PsU and seco-PsK showed good activity (IC50 3.1–3.8 μM) against E. faecalis, comparable to the reference drug vancomycin (4.2 μM). PMID:21556163

  19. Cytotoxic and antimicrobial activity of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea).

    PubMed

    Correa, Hebelin; Aristizabal, Fabio; Duque, Carmenza; Kerr, Russell

    2011-03-04

    To expand the potential of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia islands (southwest Caribbean Sea), we report the anti-microbial profile against four pathogenic microorganisms (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans) and report a more complete cytotoxic profile against five human cells lines (HeLa, PC-3, HCT116, MCF-7 and BJ) for the compounds PsG, PsP, PsQ, PsS, PsT, PsU, 3-O-acetyl-PsU, seco-PsJ, seco-PsK and IMNGD. For the cytotoxic profiles, all compounds evaluated showed moderate and non-selective activity against both tumor and normal cell lines, where PsQ and PsG were the most active compounds (GI₅₀ values between 5.8 μM to 12.0 μM). With respect to their anti-microbial activity the compounds showed good and selective activity against the Gram-positive bacteria, while they did not show activity against the Gram-negative bacterium or yeast. PsU, PsQ, PsS, seco-PsK and PsG were the most active compounds (IC₅₀ 2.9-4.5 μM) against S. aureus and PsG, PsU and seco-PsK showed good activity (IC₅₀ 3.1-3.8 μM) against E. faecalis, comparable to the reference drug vancomycin (4.2 μM).

  20. Three-Dimensional Geologic Model of Complex Fault Structures in the Upper Seco Creek Area, Medina and Uvalde Counties, South-Central Texas

    USGS Publications Warehouse

    Pantea, Michael P.; Cole, James C.; Smith, Bruce D.; Faith, Jason R.; Blome, Charles D.; Smith, David V.

    2008-01-01

    This multimedia report shows and describes digital three-dimensional faulted geologic surfaces and volumes of the lithologic units of the Edwards aquifer in the upper Seco Creek area of Medina and Uvalde Counties in south-central Texas. This geologic framework model was produced using (1) geologic maps and interpretations of depositional environments and paleogeography; (2) lithologic descriptions, interpretations, and geophysical logs from 31 drill holes; (3) rock core and detailed lithologic descriptions from one drill hole; (4) helicopter electromagnetic geophysical data; and (5) known major and minor faults in the study area. These faults were used because of their individual and collective effects on the continuity of the aquifer-forming units in the Edwards Group. Data and information were compared and validated with each other and reflect the complex relationships of structures in the Seco Creek area of the Balcones fault zone. This geologic framework model can be used as a tool to visually explore and study geologic structures within the Seco Creek area of the Balcones fault zone and to show the connectivity of hydrologic units of high and low permeability between and across faults. The software can be used to display other data and information, such as drill-hole data, on this geologic framework model in three-dimensional space.

  1. Conceptualizing the role of sediment in sustaining ecosystem services: Sediment-ecosystem regional assessment (SEcoRA).

    PubMed

    Apitz, Sabine E

    2012-01-15

    There is a growing trend to include a consideration of ecosystem services, the benefits that people obtain from ecosystems, within decision frameworks. Not more than a decade ago, sediment management efforts were largely site-specific and held little attention except in terms of managing contaminant inputs and addressing sediments as a nuisance at commercial ports and harbors. Sediments figure extensively in the Millennium Ecosystem Assessment; however, contaminated sediment is not the dominant concern. Rather, the focus is on land and water use and management on the landscape scale, which can profoundly affect soil and sediment quality, quantity and fate. Habitat change and loss, due to changes in sediment inputs, whether reductions (resulting in the loss of beaches, storm protection, nutrient inputs, etc.) or increases (resulting in lake, reservoir and wetland infilling, coral reef smothering, etc.); eutrophication and reductions in nutrient inputs, and disturbance due to development and fishing practices are considered major drivers, with significant consequences for biodiversity and the provision and resilience of ecosystem functions and services. As a mobile connecting medium between various parts of the ecosystem via the hydrocycle, sediments both contaminated and uncontaminated, play both positive and negative roles in the viability and sustainability of social, economic, and ecological objectives. How these roles are interpreted depends upon whether sediment status (defined in terms of sediment quality, quantity, location and transport) is appropriate to the needs of a given endpoint; understanding and managing the dynamic interactions of sediment status on a diverse range of endpoints at the landscape or watershed scale should be the focus of sediment management. This paper seeks to provide a language and conceptual framework upon which sediment-ecosystem regional assessments (SEcoRAs) can be developed in support of that goal.

  2. Summary statistics and graphical comparisons of historical hydrologic and water-quality data, Seco Creek Watershed, South-Central Texas

    USGS Publications Warehouse

    Brown, David W.; Slattery, Richard N.; Gilhousen, Jon R.

    1998-01-01

    The U.S. Geological Survey collected hydrologic (rainfall, streamflow, and reservoir content) and water-quality data in the Seco Creek watershed, south-central Texas. Most of the data from 15 sites were collected as part of a study in cooperation with the U.S. Department of Agriculture and the Texas State Soil and Water Conservation Board to evaluate the effects of agricultural best-management practices on surface- and ground-water quantity and quality in the 255-square-mile watershed. Nearly 400 best-management practices at 58 sites were implemented by landowners in the watershed during March 1990-September 1995. Most of the data are from the early 1990s, the period during and after implementation of best-management practices. Data from five sites include water quality and are summarized in tables and graphics in the text; and data from all 15 sites are summarized on a diskette. Maximum annual rainfall among the sites for which data are presented in the text (excluding one site) for the during-and-after-implementation period (March 1990-September 1995) was 53.27 inches in water year 1992. Maximum annual total streamflow among the sites for the period was 63,400 acre-feet, also in water year 1992. At the one site with water-quality data (under base-flow conditions) for both the before-implementation period and the during-and-after implementation period of best-management practices, percentiles (5, 25, 50, 75, 95) for specific conductance, nitrate concentration, and fecal coliform density were less for the during-and-after-implementation period than for the before-implementation period.

  3. Conceptualizing the role of sediment in sustaining ecosystem services: Sediment-ecosystem regional assessment (SEcoRA).

    PubMed

    Apitz, Sabine E

    2012-01-15

    There is a growing trend to include a consideration of ecosystem services, the benefits that people obtain from ecosystems, within decision frameworks. Not more than a decade ago, sediment management efforts were largely site-specific and held little attention except in terms of managing contaminant inputs and addressing sediments as a nuisance at commercial ports and harbors. Sediments figure extensively in the Millennium Ecosystem Assessment; however, contaminated sediment is not the dominant concern. Rather, the focus is on land and water use and management on the landscape scale, which can profoundly affect soil and sediment quality, quantity and fate. Habitat change and loss, due to changes in sediment inputs, whether reductions (resulting in the loss of beaches, storm protection, nutrient inputs, etc.) or increases (resulting in lake, reservoir and wetland infilling, coral reef smothering, etc.); eutrophication and reductions in nutrient inputs, and disturbance due to development and fishing practices are considered major drivers, with significant consequences for biodiversity and the provision and resilience of ecosystem functions and services. As a mobile connecting medium between various parts of the ecosystem via the hydrocycle, sediments both contaminated and uncontaminated, play both positive and negative roles in the viability and sustainability of social, economic, and ecological objectives. How these roles are interpreted depends upon whether sediment status (defined in terms of sediment quality, quantity, location and transport) is appropriate to the needs of a given endpoint; understanding and managing the dynamic interactions of sediment status on a diverse range of endpoints at the landscape or watershed scale should be the focus of sediment management. This paper seeks to provide a language and conceptual framework upon which sediment-ecosystem regional assessments (SEcoRAs) can be developed in support of that goal. PMID:21762956

  4. Unprecedented 1,14-seco-crotofolanes from Croton insularis: oxidative cleavage of crotofolin C by a putative homo-Baeyer-Villiger rearrangement.

    PubMed

    Maslovskaya, Lidiya A; Savchenko, Andrei I; Pierce, Carly J; Gordon, Victoria A; Reddell, Paul W; Parsons, Peter G; Williams, Craig M

    2014-10-27

    EBC-162 isolated from Croton insularis, obtained from the northern rainforest of Australia, was structurally affirmed as crotofolin C (4). Novel oxidative degradation products, EBC-233 and EBC-300, which are the first crotofolane endoperoxides, were also isolated. Both endoperoxides were found to be stable intermediates, which are proposed to undergo an unprecedented homo-Baeyer-Villiger biosynthetic rearrangement to give a new class of 1,14-seco-crotofolane diterpenes. Prolonged storage of all isolates assisted in authenticating their natural product status. Anticancer activities of reported compounds are presented.

  5. A new approach to the design of novel inhibitors of Na+,K+-ATPase: 17alpha-substituted seco-D 5beta-androstane as cassaine analogues.

    PubMed

    De Munari, S; Barassi, P; Cerri, A; Fedrizzi, G; Gobbini, M; Mabilia, M; Melloni, P

    1998-07-30

    A new three-dimensional model for the relative binding mode of cassaine 1 and digitoxigenin 2 at the digitalis receptor site is proposed on the basis of the structural and conformational similarities among 1, 2 and its 14,15-seco analogues 3 and 4. Accordingly, the speculation that also 17alpha-substituted derivatives of the digitalis 5beta,14beta-androstane skeleton could efficiently bind to the Na+,K+-ATPase receptor is put forward and verified through the synthesis of some related compounds. The binding affinity shown by 2-(N,N-dimethylamino)ethyl 3beta, 14-dihydroxy-5beta,14beta-androstane-17alpha-acrylate 6 (IC50 = 5.89 microM) and, much more significantly, by the corresponding 14, 15-seco-14-oxo derivative 9 (IC50 = 0.12 microM) substantiates the new hypothesis and opens new prospects to the design of novel inhibitors of Na+,K+-ATPase as potential positive inotropic compounds. PMID:9685243

  6. Preselection of A- and B- modified d-homo lactone and d-seco androstane derivatives as potent compounds with antiproliferative activity against breast and prostate cancer cells - QSAR approach and molecular docking analysis.

    PubMed

    Kovačević, Strahinja Z; Podunavac-Kuzmanović, Sanja O; Jevrić, Lidija R; Vukić, Vladimir R; Savić, Marina P; Djurendić, Evgenija A

    2016-10-10

    The problem with trial-and-error approach in organic synthesis of targeted anticancer compounds can be successfully avoided by computational modeling of molecules, docking studies and chemometric tools. It has been proven that A- and B- modified d-homo lactone and d-seco androstane derivatives are compounds with significant antiproliferative activity against estrogen-independent breast adenocarcinoma (ER-, MDA-MB-231) and androgen-independent prostate cancer cells (AR-, PC-3). This paper presents the quantitative structure-activity relationship (QSAR) models based on artificial neural networks (ANNs) which are able to predict whether d-homo lactone and/or d-seco androstane-based compounds will express antiproliferative activity against breast cancer cells (MDA-MB-231) or not. Also, the present paper describes the molecular docking study of 3β-acetoxy-5α,6α-epoxy- (3) and 6α,7α-epoxy-1,4-dien-3-one (24) d-homo lactone androstane derivatives, as well as 4-en-3-one (15) d-seco androstane derivative, which are compounds with strong or moderate antiproliferative activity against prostate cancer cells (PC-3), and compares them with commercially available medicament for prostate cancer - abiraterone. The obtained promising results can be used as guidelines in further syntheses of novel d-homo lactone and d-seco androstane derivatives with antiproliferative activity against breast and prostate cancer cells.

  7. Simulation of flow and effects of best-management practices in the upper Seco Creek basin, south-central Texas, 1991-98

    USGS Publications Warehouse

    Brown, David S.; Raines, Timothy H.

    2002-01-01

    The Hydrological Simulation Program?FORTRAN model was used to assess the effects of two best-management practices?brush management (removal of woody species locally known as cedar) and weather modification (rainfall enhancement)?on selected hydrologic processes in six subbasins that compose the upper Seco Creek Basin in south-central Texas. A parameter set for use with the model was developed to simulate surface-water-budget components for the six gaged subbasins. Simulation of brush management, represented by decreases in simulated evapotranspiration of 5 to 6 percent, resulted in increases of 1 to 47 percent in annual runoff and increases of 14 to 48 percent in surface runoff for the six subbasins. Simulation of weather modification, represented by a 10-percent increase in rainfall totals and intensities, resulted in increases of 5 to 6 percent in evapotranspiration, increases of 2 to 92 percent in annual runoff, and increases of 36 to 101 percent in surface runoff. Rainfall and runoff data for the study were collected during January 1, 1991?September 30, 1998. Data from 60 storms were used for the simulations. The model was calibrated with data from 33 storms (in two subbasins) and tested with data from 27 storms (in four subbasins). Twenty-one pervious land segments were defined for the study on the basis of geology and land cover. An error analysis and a sensitivity analysis were done on each subbasin, and the results were used to develop the final parameter set.

  8. Z-Bisdehydrodoisynolic acid (Z-BDDA): an estrogenic seco-steroid that enhances behavioral recovery following moderate fluid percussion brain injury in male rats.

    PubMed

    Neese, Steven L; Clough, Rich W; Banz, William J; Smith, Douglas C

    2010-11-29

    Several lines of research suggest that estrogens (and estrogenic compounds) are neuroprotective following experimental traumatic brain injury. However, therapeutic use of estrogens in this and other regards remains controversial. Therefore, analysis of estrogen-like compounds without potential problems similar to estrogens seems warranted. (±) Z-Bisdehydrodoisynolic acid (Z-BDDA) is a seco-steroid that has potent estrogenic as well as antioxidant activities in vitro and in vivo. We evaluated the therapeutic potential of Z-BDDA (300μg/0.1cc/100g body weight, sc) to promote the recovery of behavioral function following lateral fluid percussion injury (FPI) to the brain in male rats. Two hours subsequent to FPI, treatment with Z-BDDA began with a bolus subcutaneous (sc) injection followed by booster treatments given 24 and 48h later. Behavioral testing was initiated on the second day after FPI and results of Z-BDDA treatments were compared to treatment with vehicle only and to sham FPI surgery. Z-BDDA effectively enhanced recovery of coordinated limb movement assessed by locomotor placing performance across the duration of the study. Z-BDDA treated animals also performed better on a spatial memory task in the Morris water maze, showing improved learning curves across days of testing. Vestibulomotor function, measured by beam walk performance, appeared to improve in Z-BDDA treated animals, however these results did not reach statistical significance (p>0.05). Following cessation of the behavioral testing, all animals underwent assessments of gross neuroanatomical pathology. Cortical lesion size and cell death analysis with Fluoro-jade B failed to reveal Z-BDDA enhanced neuroprotection. These findings support our hypothesis that Z-BDDA can facilitate behavioral recovery following FPI in adult male rats although the mechanism(s) of these effects remain to be determined. PMID:20869954

  9. Technical evaluation of the adequacy of station electric distribution system voltages for the Rancho Seco Nuclear Generating Station, Unit No. 1: selected issues program (Docket No. 50-312)

    SciTech Connect

    White, R. L.

    1981-11-10

    This report documents the technical evaluation of the adequacy of the station electric distribution system voltages for the Rancho Seco Nuclear Generation Station, Unit No. 1. The evaluation is to determine if the onsite distribution system, in conjunction with the offsite power sources, has sufficient capacity to automatically start and operate all Class 1E loads within the equipment voltage ratings under certain conditions established by the Nuclear Regulatory Commission. The licensee demonstrates with the analysis that with certain modifications the guidelines and requirements of the NRC will be met.

  10. The Ni-Cu-PGE mineralized Brejo Seco mafic-ultramafic layered intrusion, Riacho do Pontal Orogen: Onset of Tonian (ca. 900 Ma) continental rifting in Northeast Brazil

    NASA Astrophysics Data System (ADS)

    Salgado, Silas Santos; Ferreira Filho, Cesar Fonseca; Caxito, Fabrício de Andrade; Uhlein, Alexandre; Dantas, Elton Luiz; Stevenson, Ross

    2016-10-01

    The Brejo Seco mafic-ultramafic Complex (BSC) occurs at the extreme northwest of the Riacho do Pontal Orogen Internal Zone, in the northern margin of the São Francisco Craton in Northeast Brazil. The stratigraphy of this medium size (3.5 km wide and 9 km long) layered intrusion consists of four main zones, from bottom to top: Lower Mafic Zone (LMZ; mainly troctolite), Ultramafic Zone (UZ; mainly dunite and minor troctolite); Transitional Mafic Zone (TMZ; mainly troctolite) and an Upper Mafic Zone (UMZ; gabbro and minor anorthosite, troctolite, and ilmenite magnetitite). Ni-Cu-PGE mineralization occurs at the contact of the UZ with the TMZ, consisting of an up to 50 m thick stratabound zone of disseminated magmatic sulfides. An Mg-tholeiitic affinity to the parental magma is indicated by the geochemical fractionation pattern, by the magmatic crystallization sequence and by the elevated Fo content in olivine. A Smsbnd Nd isochron yielded an age of 903 ± 20 Ma, interpreted as the age of crystallization, with initial εNd = 0.8. Evidence of interaction of the BSC parental magma with sialic crust is given by the Rare Earth and trace element patterns, and by slightly negative and overall low values of εNd(900 Ma) in between -0.2 and +3.3. Contrary to early interpretations that it might constitute an ophiolite complex, based mainly on the geochemistry of the host rocks (Morro Branco metavolcanosedimentary complex), here we interpret the BSC as a typical layered mafic-ultramafic intrusion in continental crust, related to an extensional regime. The BSC is chrono-correlated to mafic dyke swarms, anorogenic granites and thick bimodal volcanics of similar age and tectonic setting in the São Francisco Craton and surrounding areas. Intrusion of the BSC was followed by continued lithospheric thinning, which led to the development of the Paulistana Complex continental rift volcanics around 888 Ma and ultimately to plate separation and the generation of new oceanic crust (Monte

  11. Geological, hydrological, and biological issues related to the proposed development of a park at the confluence of the Los Angeles River and the Arroyo Seco, Los Angeles County, California

    USGS Publications Warehouse

    Land, Michael; Trenham, Peter C.; Ponti, Daniel J.; Reichard, Eric G.; Tinsley, John C.; Warrick, Jonathan A.; Meyer, Robert W.

    2005-01-01

    A new park is being considered for the confluence of the Los Angeles River and the Arroyo Seco in Los Angeles County, California. Components of the park development may include creation of a temporary lake on the Los Angeles River, removal of channel lining along part of the Arroyo Seco, restoration of native plants, creation of walking paths, and building of facilities such as a boat ramp and a visitor center. This report, prepared in cooperation with the Mountains Recreation and Conservancy Authority, delineates the geological, hydrological, and biological issues that may have an impact on the park development or result from development at the confluence, and identifies a set a tasks to help address these science issues. Geologic issues of concern relate to surface faulting, earthquake ground motions, liquefaction, landsliding, and induced seismicity. Hydrologic issues of concern relate to the hydraulics and water quality of both surface water and ground water. Biological issues of concern include colonization-extinction dynamics, wildlife corridors, wildlife reintroduction, non-native species, ecotoxicology, and restoration of local habitat and ecology. Potential tasks include (1) basic data collection and follow-up monitoring, and (2) statistical and probabilistic analyses and simulation modeling of the seismic, hydraulic, and ecological processes that may have the greatest impact on the park. The science issues and associated tasks delineated for the proposed confluence park will also have transfer value for river restoration in other urban settings.

  12. Eduardo Primo Yúfera, founder of Revista de Agroquímica y Tecnología de Alimentos and pioneer on food science and technology research in Spain.

    PubMed

    Ayala-Gascón, M; Aleixandre-Benavent, R; Gandía-Balaguer, A

    2011-12-01

    Eduardo Primo Yúfera was the founder and director of the Instituto de Agroquímica y Tecnología de Alimentos (IATA, 1957-1974) until he was appointed president of the Consejo Superior de Investigaciones Científicas (CSIC). His aim to publicize food science led him to create the Revista de Agroquímica y Tecnología de Alimentos in 1961, the forerunner of this journal, Food Science and Technology International, which he directed until 1977. Of his scientific output, 50% has been published in this journal. He is considered to be the promoter and exponent of Food Science and Technology and Chemical Ecology in Spain as well as the instigator of the country's innovation model (R&D and innovation). In his work, he was able to combine basic research excellence and socially relevant applied research to move both science and society forward. He was an example and inspiration to many colleagues and followers. The aim of this study is to highlight the influence and importance of Primo Yúfera in the formation, development and consolidation of the journal Revista de Agroquímica y Tecnología de Alimentos, and to appraise his scientific contribution to this journal.

  13. Crystal structure and DFT calculations of 3,4- seco-lup-20(29)-en-3-oic acid isolated from Wrightia tinctoria: Stacking of supramolecular dimers in the crystal lattice

    NASA Astrophysics Data System (ADS)

    Ghosh, Anindita; Sarkar, Ananda; Mitra, Partha; Banerji, Avijit; Banerji, Julie; Mandal, Suvra; Das, Manosi

    2010-09-01

    3,4- Seco-lup-20(29)-en-3-oic acid ( 1), a rare triterpene, was isolated from Wrightia tinctoria R.Br (Family: Apocyanaceae). It appeared promising to study the structural chemistry of this compound because of its unique bio activity. X-ray diffraction analysis demonstrated that this compound consists of three six membered rings and one five membered ring. The first six membered ring (A) is in the twist boat form while the remaining two six membered rings (B, C) are in the chair form. The crystal of this compound belongs - to the monoclinic crystal system and space group P2 1. Lattice constituents are as follows: a = 13.074(6) Å, b = 11.972(5) Å, c = 17.394(7) Å; α = 90.00°, β = 98.20(13)°, γ = 90.00°; V = 2695(2) Å 3, d = 1.094 Mg/m 3, Z = 4. The optimized geometry of the reported molecule has been calculated with the DFT/B3LYP theory using 6-31G(d,p) basis set.

  14. Novel and unusual triterpene from Black Cohosh. Determination of structure of 9,10- seco-9,19-cyclolanostane xyloside (cimipodocarpaside) by NMR, IR and Raman spectroscopy and DFT calculations

    NASA Astrophysics Data System (ADS)

    Jamróz, Marta K.; Jamróz, Michał H.; Dobrowolski, Jan Cz.; Gliński, Jan A.; Davey, Matthew H.; Wawer, Iwona

    2011-01-01

    A new triterpene xyloside, designated cimipodocarpaside was isolated from a Black Cohosh ( Actea racemosa L.) extract and its structure was elucidated by means of 1H, 13C NMR, IR and Raman spectroscopy supported by B3LYP/6-31G** calculations. The vibrational spectra were interpreted using the PED analysis of 273 fundamentals. Its structure comprises four condensed rings A-D which are 6, 7, 6, and 5-membered, respectively. An oxiirane ring is located in the side chain and a xylose moiety is attached to the A-ring. Comparison of the experimental 13C NMR data with the theoretical chemical shifts of 24 S- and 24 R-cimipodocarpaside isomers revealed that the isolated compound has the 24 S-configuration. Combined spectroscopic and computational studies enabled the determination of the structure of cimipodocarpaside as (24 S)-3β-hydroxy-24,25-oxiirane-16,23-dione-9,10- seco-9,19-cyclolanost-7(8),9(11),10(19)-trien-3-O-β- D-xylopyranoside. Triterpenes with 7-membered ring were thus far isolated from only Actea podocarpa DC. plants. This is the first report on the isolation of such a compound from Black Cohosh.

  15. Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13-Acetate-like Properties

    PubMed Central

    2015-01-01

    The seco-B-ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 30 total steps with three bonds formed via hydrogen-mediated C–C coupling. This synthetic route features a palladium-catalyzed alkoxycarbonylation of a C2-symmetric diol to form the C9-deoxygenated bryostatin A-ring. WN-1 binds to PKCα (Ki = 16.1 nM) and inhibits the growth of multiple leukemia cell lines. Although structural features of the WN-1 A-ring and C-ring are shared by analogues that display bryostatin-like behavior, WN-1 displays PMA-like behavior in U937 cell attachment and proliferation assays, as well as in K562 and MV-4-11 proliferation assays. Molecular modeling studies suggest the pattern of internal hydrogen bonds evident in bryostatin 1 is preserved in WN-1, and that upon docking WN-1 into the crystal structure of the C1b domain of PKCδ, the binding mode of bryostatin 1 is reproduced. The collective data emphasize the critical contribution of the B-ring to the function of the upper portion of the molecule in conferring a bryostatin-like pattern of biological activity. PMID:25207655

  16. Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.

    PubMed

    Andrews, Ian P; Ketcham, John M; Blumberg, Peter M; Kedei, Noemi; Lewin, Nancy E; Peach, Megan L; Krische, Michael J

    2014-09-24

    The seco-B-ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 30 total steps with three bonds formed via hydrogen-mediated C-C coupling. This synthetic route features a palladium-catalyzed alkoxycarbonylation of a C2-symmetric diol to form the C9-deoxygenated bryostatin A-ring. WN-1 binds to PKCα (Ki = 16.1 nM) and inhibits the growth of multiple leukemia cell lines. Although structural features of the WN-1 A-ring and C-ring are shared by analogues that display bryostatin-like behavior, WN-1 displays PMA-like behavior in U937 cell attachment and proliferation assays, as well as in K562 and MV-4-11 proliferation assays. Molecular modeling studies suggest the pattern of internal hydrogen bonds evident in bryostatin 1 is preserved in WN-1, and that upon docking WN-1 into the crystal structure of the C1b domain of PKCδ, the binding mode of bryostatin 1 is reproduced. The collective data emphasize the critical contribution of the B-ring to the function of the upper portion of the molecule in conferring a bryostatin-like pattern of biological activity.

  17. Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.

    PubMed

    Andrews, Ian P; Ketcham, John M; Blumberg, Peter M; Kedei, Noemi; Lewin, Nancy E; Peach, Megan L; Krische, Michael J

    2014-09-24

    The seco-B-ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 30 total steps with three bonds formed via hydrogen-mediated C-C coupling. This synthetic route features a palladium-catalyzed alkoxycarbonylation of a C2-symmetric diol to form the C9-deoxygenated bryostatin A-ring. WN-1 binds to PKCα (Ki = 16.1 nM) and inhibits the growth of multiple leukemia cell lines. Although structural features of the WN-1 A-ring and C-ring are shared by analogues that display bryostatin-like behavior, WN-1 displays PMA-like behavior in U937 cell attachment and proliferation assays, as well as in K562 and MV-4-11 proliferation assays. Molecular modeling studies suggest the pattern of internal hydrogen bonds evident in bryostatin 1 is preserved in WN-1, and that upon docking WN-1 into the crystal structure of the C1b domain of PKCδ, the binding mode of bryostatin 1 is reproduced. The collective data emphasize the critical contribution of the B-ring to the function of the upper portion of the molecule in conferring a bryostatin-like pattern of biological activity. PMID:25207655

  18. 27 CFR 9.59 - Arroyo Seco.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... approximately 7.5 miles to U.S. Highway 101 at the intersection of Underwood Road. (7) Then east following Underwood Road to its intersection with the Posa de los Ositos Land Grant. (8) Then north following...

  19. 27 CFR 9.59 - Arroyo Seco.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 9.59 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF..., California,” 7.5 minute series, edition of 1955; and (4) “Sycamore Flat, California,” 7.5 minute series... Monterey County, California. The beginning point is found on the “Sycamore Flat” U.S.G.S. map at...

  20. Rings D-seco and B,D-seco tetranortriterpenoids from root bark of Entandrophragma angolense.

    PubMed

    Nsiama, Tienabe K; Okamura, Hiroaki; Hamada, Toshiyuki; Morimoto, Yoshiki; Doe, Matsumi; Iwagawa, Tetsuo; Nakatani, Munehiro

    2011-10-01

    Investigation of the root bark extract of Entandrophragma angolense led to identification of two gedunin-type limonoids 5-hydroxy-7-deacetoxy-7-oxogedunin and 5,6-dehydro-7-deacetoxy-7-oxogedunin, and three methyl angolensate derivatives, 6-deacetoxydomesticulide D, 6-deacetoxydomesticulide D 21-methylether, and entangosin, together with known compounds, methyl angolensate, 6-acetoxymethyl angolensate and secomahoganin. Their structures were established by extensive NMR experiments in conjunction with mass spectrometry. Entangosin is a rare example of a limonoid derivative having a fully O-substituted furan moiety. PMID:21742354

  1. Pseudomonas mutant strains that accumulate androstane and seco-androstane intermediates from bile acids.

    PubMed Central

    Leppik, R A; Sinden, D J

    1987-01-01

    Transposon mutant strains which were affected in bile acid catabolism were isolated from four Pseudomonas spp. Two of the mutant groups isolated were found to accumulate 12 alpha-hydroxyandrosta-1,4-diene-3,17-dione as the major product from deoxycholic acid. Strains in one of these two groups were able to grow on steroids such as chenodeoxycholic acid, which lacks a 12 alpha-hydroxy function, whereas the one member of the second group could not. With chenodeoxycholic acid, this latter strain accumulated a yellow muconic-like derivative, tentatively identified as 3,7-dihydroxy-5,9,17-trioxo-4(5),9(10)-disecoandrosta-1(10)2 -dien-4-oic acid. Members of two further mutant groups accumulated either 12 beta-hydroxyandrosta-1,4-diene-3,17-dione or 3,12 beta-dihydroxy-9(10)-secoandrosta-1,3,5(10)-triene-9,17-dione as the major product from deoxycholic acid. The relationship between the catabolism of m- and p-cresol, 3-ethylphenol and the bile acids was also examined. PMID:3038076

  2. Environmental radiological studies downstream from the Rancho Seco Nuclear Power Generating Station - 1985. Appendices. Part II

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Brunk, J.L.; Jokela, T.A.

    1986-01-23

    Eight appendices address the following concentrations of radionuclides: in fish; in frog legs; in crayfish; in sediments; in soil samples; in surface and ground water samples; in water hyacinths; and in beef samples.

  3. Sedative effect of galphimine B, a nor-seco-triterpenoid from Galphimia glauca.

    PubMed

    Tortoriello, J; Ortega, A

    1993-10-01

    Galphimia glauca Cav. (Malpighiaceae) is used in Mexican traditional medicine as a sedative in the treatment of mental disorders. Sedative properties of a methanolic extract of the aerial parts of this plant have been established in animal trials and an active compound, named galphimine B, has already been isolated. This compound was submitted to neuropharmacological testing, where it was shown that galphimine B had no significant effect as an anticonvulsant, while it exhibited a strong depressant activity on the nervous system. PMID:8255929

  4. Sedative effect of galphimine B, a nor-seco-triterpenoid from Galphimia glauca.

    PubMed

    Tortoriello, J; Ortega, A

    1993-10-01

    Galphimia glauca Cav. (Malpighiaceae) is used in Mexican traditional medicine as a sedative in the treatment of mental disorders. Sedative properties of a methanolic extract of the aerial parts of this plant have been established in animal trials and an active compound, named galphimine B, has already been isolated. This compound was submitted to neuropharmacological testing, where it was shown that galphimine B had no significant effect as an anticonvulsant, while it exhibited a strong depressant activity on the nervous system.

  5. 77 FR 26569 - Llano Seco Riparian Sanctuary Unit Restoration and Pumping Plant/Fish Screen Facility Protection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... to prevent river meander. Alternative 2: Spur Dikes and Site-Specific Plantings Under Alternative 2, bank protection measures would consist of installing eight rock spur dikes along the Sacramento River on the northern side of the Riparian Sanctuary. The dike field would extend about 2,000 feet...

  6. Engineering of a Nepetalactol-Producing Platform Strain of Saccharomyces cerevisiae for the Production of Plant Seco-Iridoids.

    PubMed

    Campbell, Alex; Bauchart, Philippe; Gold, Nicholas D; Zhu, Yun; De Luca, Vincenzo; Martin, Vincent J J

    2016-05-20

    The monoterpene indole alkaloids (MIAs) are a valuable family of chemicals that include the anticancer drugs vinblastine and vincristine. These compounds are of global significance-appearing on the World Health Organization's list of model essential medicines-but remain exorbitantly priced due to low in planta levels. Chemical synthesis and genetic manipulation of MIA producing plants such as Catharanthus roseus have so far failed to find a solution to this problem. Synthetic biology holds a potential answer, by building the pathway into more tractable organisms such as Saccharomyces cerevisiae. Recent work has taken the first steps in this direction by producing small amounts of the intermediate strictosidine in yeast. In order to help improve on these titers, we aimed to optimize the early biosynthetic steps of the MIA pathway to the metabolite nepetalactol. We combined a number of strategies to create a base strain producing 11.4 mg/L of the precursor geraniol. We also show production of the critical intermediate 10-hydroxygeraniol and demonstrate nepetalactol production in vitro. Lastly we demonstrate that activity of the iridoid synthase toward the intermediates geraniol and 10-hydroxygeraniol results in the synthesis of the nonproductive intermediates citronellol and 10-hydroxycitronellol. This discovery has serious implications for the reconstruction of the MIA in heterologous organisms.

  7. Seco-taondiol, an unusual meroterpenoid from the Chilean seaweed Stypopodium flabelliforme and its gastroprotective effect in mouse model.

    PubMed

    Areche, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M; García-Beltrán, Olimpo; Simirgiotis, Mario J; Sepúlveda, Beatriz

    2015-04-01

    Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the first time from this species. The molecular structure of the new metabolite was determined by spectroscopic methods based on 1D- and 2D-NMR. Isolation of 7 represents a key step toward a better understanding of the biogenesis of this class of meroterpenoids. Among the meroditerpenoids isolated, stypodiol, isoepitaondiol, epitaondiol and sargaol exhibited gastroprotective activity on the HCl/Ethanol-induced gastric lesions model in mice. Regarding the mode of gastroprotective action, the activity of epitaondiol was reversed significantly when animals were pretreated with indomethacin, N-ethylmaleimide and N-nitro-l-arginine methyl ester (L-NAME) suggesting that prostaglandins, sulfhydryl groups and nitric oxide are involved in their mode of gastroprotective action. In the case of sargaol the gastroprotective activity was attenuated with indomethacin and N-ethylmaleimide, which suggests that prostaglandins and sulfhydryl groups are also involved in the mode of action using this model. PMID:25830679

  8. 78 FR 76317 - Llano Seco Riparian Sanctuary Unit Restoration and Pumping Plant/Fish Screen Facility Protection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... Register (77 FR 26569, May 4, 2012). We held a public meeting to solicit comments on the Draft EIS/EIR on... nonnative and invasive noxious weeds. Currently, just over 200 acres is farmed to dryland cereal crops to help control nonnative weeds. Prior to acquisition by the Service, rock revetment was placed on...

  9. 76 FR 20368 - Llano Seco Riparian Sanctuary Unit Restoration and Pumping Plant/Fish Screen Facility Protection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ...-PID pumping plant and fish screen facility. Previous Planning Studies In 2001, River Partners... developed based on the River Partners 2005 feasibility study, the 2010 Ayres feasibility study, and public input received during this scoping period. The 2005 River Partners study identified restoration...

  10. Seco-taondiol, an unusual meroterpenoid from the Chilean seaweed Stypopodium flabelliforme and its gastroprotective effect in mouse model.

    PubMed

    Areche, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M; García-Beltrán, Olimpo; Simirgiotis, Mario J; Sepúlveda, Beatriz

    2015-03-30

    Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the first time from this species. The molecular structure of the new metabolite was determined by spectroscopic methods based on 1D- and 2D-NMR. Isolation of 7 represents a key step toward a better understanding of the biogenesis of this class of meroterpenoids. Among the meroditerpenoids isolated, stypodiol, isoepitaondiol, epitaondiol and sargaol exhibited gastroprotective activity on the HCl/Ethanol-induced gastric lesions model in mice. Regarding the mode of gastroprotective action, the activity of epitaondiol was reversed significantly when animals were pretreated with indomethacin, N-ethylmaleimide and N-nitro-l-arginine methyl ester (L-NAME) suggesting that prostaglandins, sulfhydryl groups and nitric oxide are involved in their mode of gastroprotective action. In the case of sargaol the gastroprotective activity was attenuated with indomethacin and N-ethylmaleimide, which suggests that prostaglandins and sulfhydryl groups are also involved in the mode of action using this model.

  11. Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium flabelliforme and Its Gastroprotective Effect in Mouse Model

    PubMed Central

    Areche, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M.; García-Beltrán, Olimpo; Simirgiotis, Mario J.; Sepúlveda, Beatriz

    2015-01-01

    Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the first time from this species. The molecular structure of the new metabolite was determined by spectroscopic methods based on 1D- and 2D-NMR. Isolation of 7 represents a key step toward a better understanding of the biogenesis of this class of meroterpenoids. Among the meroditerpenoids isolated, stypodiol, isoepitaondiol, epitaondiol and sargaol exhibited gastroprotective activity on the HCl/Ethanol-induced gastric lesions model in mice. Regarding the mode of gastroprotective action, the activity of epitaondiol was reversed significantly when animals were pretreated with indomethacin, N-ethylmaleimide and N-nitro-l-arginine methyl ester (L-NAME) suggesting that prostaglandins, sulfhydryl groups and nitric oxide are involved in their mode of gastroprotective action. In the case of sargaol the gastroprotective activity was attenuated with indomethacin and N-ethylmaleimide, which suggests that prostaglandins and sulfhydryl groups are also involved in the mode of action using this model. PMID:25830679

  12. Synthesis of novel vitamin D3 analog with an additional ring annulated to A and seco-B rings.

    PubMed

    Sokolowska, Katarzyna; Sicinski, Rafal R

    2014-09-01

    A simple method for the synthesis of yet unknown 5E-vitamin D3 analogs with an additional six-membered ring connecting C-6 and C-19 was developed. Ring-closing metathesis (RCM) was used for efficient formation thereof from the corresponding 5E-isomers of 6-alkenyl vitamin D3 compounds which in turn were prepared from the 6-oxo-3,5-cyclovitamin D3. Reinvestigation of the Grignard reactions of this latter compound as well as the following acid-catalyzed cycloreversions showed discrepancies with the literature data describing the course of such processes.

  13. 78 FR 16705 - Llano Seco Riparian Sanctuary Unit Restoration and Pumping Plant/Fish Screen Facility Protection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... methods, including public notices in local newspapers and a notice in the Federal Register (77 FR 26569... Sanctuary Unit as part of the Joint Management Agreement between Parrot Investment Co., The...

  14. Synthesis of novel vitamin D3 analog with an additional ring annulated to A and seco-B rings.

    PubMed

    Sokolowska, Katarzyna; Sicinski, Rafal R

    2014-09-01

    A simple method for the synthesis of yet unknown 5E-vitamin D3 analogs with an additional six-membered ring connecting C-6 and C-19 was developed. Ring-closing metathesis (RCM) was used for efficient formation thereof from the corresponding 5E-isomers of 6-alkenyl vitamin D3 compounds which in turn were prepared from the 6-oxo-3,5-cyclovitamin D3. Reinvestigation of the Grignard reactions of this latter compound as well as the following acid-catalyzed cycloreversions showed discrepancies with the literature data describing the course of such processes. PMID:24928728

  15. A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines.

    PubMed

    Dioum, Mbaye Diaw; Seck, Matar; Silvestre, Virginie; Planchat, Aurélien; Loquet, Denis; Lohard, Steven; Barille-Nion, Sophie; Remaud, Gerald S; Robins, Richard J; Tea, Illa

    2016-07-01

    The seeds of Carapa procera are exploited extensively in West African ethnopharmacy for the treatment of several pathologies, including inflammation. They also are effective as insect antifeedants and as a mosquito repellent. With the aim of identifying bioactive principles, an ethyl acetate extract of the defatted seeds was made and fractionated. Two principle compounds were isolated. One of these, 5,6-dehydro-7-deacetoxy-7-oxogedunin (1), while known from another genus of the Meliaceae, is newly identified from the genus Carapa and its X-ray structure is described for the first time. In addition, 1 displayed strong anti-clonogenic activity at 10 µM. The other compound, mexicanolide (2), is known from this species and showed neither cytotoxicity nor anti-clonogenicity. These differences in efficacy are discussed in relation to known structure-activity relationships of limonoids. PMID:27224268

  16. [Consumption of nuts and vegetal oil in people with type 1 diabetes mellitus].

    PubMed

    Ferrer-García, Juan Carlos; Granell Vidal, Lina; Muñoz Izquierdo, Amparo; Sánchez Juan, Carlos

    2015-06-01

    Introducción: estudios recientes han demostrado los beneficios cardiovasculares de la dieta mediterránea enriquecida con aceite de oliva y frutos secos. Las personas con diabetes, que tienen un mayor riesgo de complicaciones cardiovasculares, podrían beneficiarse en gran medida de seguir ese tipo de patrón alimentario. Objetivos: análisis de la ingesta de grasas vegetales procedentes de frutos secos y aceites vegetales en pacientes con diabetes mellitus tipo 1 (DM1). Métodos: estudio transversal descriptivo que compara 60 personas con DM1 y 60 sujetos sanos. Se recoge la frecuencia de consumo de aceites vegetales y de frutos secos y se calcula el aporte procedente de estos alimentos en ácidos grasos mono y poliinsaturados (ácido oleico, linoleico y -linolénico). Se utilizó un cuestionario de frecuencia de consumo diseñado de forma específica. Se recogen variables antropométricas, factores de riesgo cardiovascular y variables relacionadas con la diabetes. Resultados: el consumo total de grasa vegetal procedente de aceites vegetales fue similar en los pacientes con DM1 frente a los sujetos control (3,02 ± 1,14 vs. 3,07 ± 1,27 Raciones (R)/día, P = 0,822) y de frutos secos (1,35 ± 2,24 vs. 1,60 ± 2,44 R/semana, P = 0,560). El grupo DM1 consumió menos aceite de oliva que el grupo control (2,55 ± 1,17 vs. 3,02 ± 1,34 R/día, P = 0,046). Se detectó un menor consumo de ácido -linolénico respecto al grupo control (1,13 ± 2,06 vs. 2,64 ± 4,37 g/día, P = 0,018), mientras que no hubo diferencias en el resto de ácidos grasos (oleico 28,30 ± 18,13 vs. 29,53 ± 16,90 g/día, P = 0,703; linoleico 13,70 ± 16,80 vs. 15,45 ± 19,90 g/día, P = 0,605). En los DM1 no se demostró una influencia del consumo de las grasas vegetales procedentes de aceites y frutos secos en los parámetros antropométricos, metabólicos y variables específicas de la diabetes. Conclusiones: en las personas con DM1 el consumo total de aceites vegetales y frutos secos no

  17. Revised-Confirmatory Survey Report for Portions of the Auxiliary Building Structural Surfaces and Turbine Building Embedded Piping, Rancho Seco Nuclear Generating Station, Herald, California

    SciTech Connect

    Adams, W C

    2007-12-07

    During the period of October 15 and 18, 2007, ORISE performed confirmatory radiological survey activities which included beta and gamma structural surface scans and beta activity direct measurements within the Auxiliary Building, beta or gamma scans within Turbine Building embedded piping, beta activity determinations within Turbine Building Drain 3-1-27, and gamma scans and the collection of a soil sample from the clay soils adjacent to the Lower Mixing Box.

  18. Acyclonucleosides, modified seco-nucleosides, and salicyl- or catechol-derived acyclic 5-fluorouracil O,N-acetals: antiproliferative activities, cellular differentiation and apoptosis.

    PubMed

    Marchal, Juan A; Núñez, María C; Aránega, Antonia; Gallo, Miguel A; Espinosa, Antonio; Campos, Joaquín M

    2009-01-01

    The goal of cancer chemotherapy with classical drugs - the destruction of the tumor cells - is often complicated by significant toxicity. As an alternative, induced differentiation modulates the cell programme by transforming malignant cells into mature cells with no proliferative potential. Our data demonstrate that (+/-)-1-{[3-(2-hydroxyethoxy)-1-isopropoxy]propyl}-5-fluorouracil inhibits proliferation, induces myogenic differentiation, increases the expression of proteins specifically present in normally differentiated skeletal muscle cells, and modifies the adhesion capacity of these cells against the rhabdomyosarcoma cell line RD. From a designing point of view, a benzene ring was fused to the side chain in order to increase the lipophilicity and anticancer activity of our molecules. Herein we report the preparation and biological activity of three compounds having the general formula (+/-)-1-[2-(5-substituted-2-hydroxybenzyloxy)-1-methoxyethyl]-5-fluorouracils. A catechol-derived compound such as (+/-)-1-[3-(2-hydroxyphenoxy)-1-methoxypropyl]-5-fluorouracil and two salicyl-derived compounds such as (+/-)-(Z)-1-[4-(2-hydroxyphenyl)-1-methoxy-but-3-enyl]-5-fluorouracil [(Z)-43] and its dihydrogenated derivative (+/-)-1-[4-(2-hydroxyphenyl)-1-methoxybutyl]-5-fluorouracil were prepared to complete the set of six O,N-acetals. The most active compound against the MCF-7 breast cancer cell line was (+/-)-(Z)-43 with an IC(50) = 9.40 +/- 0.64 microM. Differentiated breast cancer cells generate fat deposits within the cytoplasm. The MCF-7 cells trea-ed with (+/-)-(Z)-43 caused an increase in the lipid content over control cells after 3 days of treatment. Our results suggest that there may be significant potential advantages in the use of this new differentiating agent for the treatment of breast cancer.

  19. Physalin F, a seco-steroid from Physalis angulata L., has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy.

    PubMed

    Pinto, Lorena A; Meira, Cássio S; Villarreal, Cristiane F; Vannier-Santos, Marcos A; de Souza, Claudia V C; Ribeiro, Ivone M; Tomassini, Therezinha C B; Galvão-Castro, Bernardo; Soares, Milena B P; Grassi, Maria F R

    2016-04-01

    Human T-lymphotropic virus type 1 (HTLV-1) induces a strong activation of the immune system, especially in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. The present study aimed to investigate the effects of physalin F on peripheral blood mononuclear cells (PBMC) of HAM/TSP subjects. A concentration-dependent inhibition of spontaneous proliferation of PBMC from HAM/TSP subjects was observed in the presence of physalin F, as evaluated by (3)H-thymidine uptake. The IC50 for physalin F was 0.97 ± 0.11 μM. Flow cytometry analysis using Cytometric Bead Array (CBA) showed that physalin F (10 μM) significantly reduced the levels of IL-2, IL-6, IL-10, TNF-α and IFN-γ, but not IL-17A, in supernatants of PBMC cultures. Next, apoptosis induction was addressed by using flow cytometry to evaluate annexin V expression. Treatment with physalin F (10 μM) increased the apoptotic population of PBMC in HAM/TSP subjects. Transmission electron microscopy analysis of PBMC showed that physalin F induced ultrastructural changes, such as pyknotic nuclei, damaged mitochondria, enhanced autophagic vacuole formation, and the presence of myelin-like figures. In conclusion, physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by HTLV-1 infection.

  20. PROCENTAJE DE PSILIDOS PORTADORES DE Canidatus Liberibacter asiaticus Y SU RELACION CON LA INCIDENCIA DE HLB EN CINCO HUERTAS COMERCIALES DE LIMON MEXICANO {Citrus aurantifolia (Christm) Swingle} EN EL ESTADO DE COLIMA MEXICO

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Asian citrus psyllids (Diaphorina citri) were individually analyzed by qPCR to detect Candidatus Liberibacter asiaticus (CLas). The psyllids were collected in Mexican lime (Citrus aurantifolia) trees in five commercial orchards in Tecomán and Manzanillo, Colima with severe symptoms of classical mott...

  1. SMART GROUND Project: SMART data collection and inteGRation platform to enhance availability and accessibility of data and infOrmation in the EU territory on SecoNDary Raw Materials

    NASA Astrophysics Data System (ADS)

    Rossetti, Piergiorgio; Antonella Dino, Giovanna; de la Feld, Marco; Pizza, Antonietta; Coulon, Frederic; Wagland, Stuart; Gomes, Diogo

    2016-04-01

    The issue of resource security has come to the forefront of the debate over recent years, partly due to considerable concern over the security of supply of the so called 'critical' materials, with rare earths attracting the greatest attention in the press. Their supply is fundamental to maintain and develop EU economy and its industries relied on a steady supply of Raw Materials. Thus considering the increasing scarcity and raising prices of both, energy raw materials and other raw materials, such as metals and minerals, the recycling and recovery of these materials from anthropogenic deposits such as landfills is of increasing relevance. Europe has somewhere between 150,000 and 500,000 landfill sites, with an estimated 90% of them being "non-sanitary" pre-dating the EU Landfill Directive of 1999. Thus historical background makes the numerous old waste dumps as possible sources of critical and secondary raw materials (SRM and CRM). However, to date there is no inventory available of SRM and CRM present in EU landfills, and best management practices to recover SRM from landfill activities are inefficient. In this context, the EU SMART GROUND (SG) project (Grant Agreement No 641988) intends to foster resource recovery in landfills by improving both the availability and the accessibility of data and information on SRM in the EU and creating synergies among the different stakeholders involved in the SRM value chain. To do so, the project aims to collect and integrate in a single EU databank (SMART GROUND Data Bank) all the data from existing databases and new information retrieved during project activities. Such data will be collected from the different waste streams including municipal, industrial and mining wastes across EU landfills. It will improve data gathering on SRM from different types of waste, by defining new and integrated data acquisition methods and standards. At last, but not least, the project will also improve the SRM economic and employment potential, by i) providing training on the assessment of landfill sites material recovery to targeting end-users, ii) establishing a dedicated network of academic, industrial, regulators and other stakeholders committed to cost-effective research, technology transfer and training. The present contribution will provide an overview of the SMART GROUND project and highlights the results obtained during the first six months of project activity.

  2. A New Bacterial Steroid Degradation Gene Cluster in Comamonas testosteroni TA441 Which Consists of Aromatic-Compound Degradation Genes for Seco-Steroids and 3-Ketosteroid Dehydrogenase Genes

    PubMed Central

    Horinouchi, Masae; Hayashi, Toshiaki; Yamamoto, Takako; Kudo, Toshiaki

    2003-01-01

    In Comamonas testosteroni TA441, testosterone is degraded via aromatization of the A ring, which is cleaved by the meta-cleavage enzyme TesB, and further degraded by TesD, the hydrolase for the product of TesB. TesEFG, encoded downstream of TesD, are probably hydratase, aldolase, and dehydrogenase for degradation of 2-oxohex-4-enoicacid, one of the products of TesD. Here we present a new and unique steroid degradation gene cluster in TA441, which consists of ORF18, ORF17, tesI, tesH, ORF11, ORF12, and tesDEFG. TesH and TesI are 3-ketosteroid-Δ1-dehydrogenase and 3-ketosteroid-Δ4(5α)-dehydrogenase, respectively, which work in the early steps of steroid degradation. ORF17 probably encodes the reductase component of 9α-hydroxylase for 1,4-androstadiene-3,17-dione, which is the product of TesH in testosterone degradation. Gene disruption experiments showed that these genes are necessary for steroid degradation and do not have any isozymes in TA441. By Northern blot analysis, these genes were shown to be induced when TA441 was incubated with steroids (testosterone and cholic acid) but not with aromatic compounds [phenol, biphenyl, and 3-(3-hydroxyphenyl)propionic acid], indicating that these genes function exclusively in steroid degradation. PMID:12902225

  3. 9. SITE OVERVIEW. PART 4 OF 6 PART PANORAMA WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. SITE OVERVIEW. PART 4 OF 6 PART PANORAMA WITH NOS. CA-265-6 TO CA-265-11. ARROYO SECO PARKWAY AS SEEN FROM RADIO TOWER HILL. PART 4 SHOWS ARROYO SECO PARKWAY IN FOREGROUND AND FIGUEROA STREET AT CENTER. LOOKING 316° NW. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  4. [ASSOCIATION BETWEEN DIETARY GLYCEMIC INDEX AND GLYCEMIC LOAD AND INTIMA MEDIA THICKNESS IN A POPULATION AT HIGH CARDIOVASCULAR RISK: A SUBGROUP ANALYSIS IN THE PREDIMED TRIAL].

    PubMed

    Goñi Ruiz, Nuria; Martínez González, Miguel Ángel; Salas Salvadó, Jordi; Buil Cosiales, Pilar; Diez Espino, Javier; Martinez Vila, Eduardo; Irimia Sierra, Pablo; Ros Rahola, Emilio; Toledo Atucha, Estefania

    2015-11-01

    Introducción: el grosor de la íntima media carotídea (GIMC) es un conocido marcador de arteriosclerosis precoz y un buen predictor de eventos cardiovasculares futuros. Aunque se ha demostrado que la adhesión a la dieta mediterránea, especialmente si está enriquecida con aceite de oliva virgen extra o frutos secos, tiene efectos beneficiosos sobre los cambios en el GIMC, el papel de los carbohidratos en el desarrollo de la arterioesclerosis sigue siendo controvertido. Objetivo: valorar la relación entre el índice glucémico (IG) o la carga glucémica (CG) de la dieta y el GIMC en una población asintomática con alto riesgo cardiovascular. Métodos: en el marco del estudio PREDIMED (PREvención con Dieta MEDiterránea), se seleccionaron de manera aleatorizada 187 sujetos del centro PREDIMED- NAVARRA. A estos pacientes asintomáticos, pero con alto riesgo cardiovascular, se les realizó una ecografía carotídea basal para determinar su GIMC, y tras un año en el estudio se les repitió la misma medición. Se usó un cuestionario validado de frecuencia de consumo de alimentos (137 ítems) tanto basal como anualmente para obtener el IG y la CG, que fueron categorizados en cuartiles, tras ser ajustados por energía. Mediante modelos multivariables (ANCOVA) se estudió la posible asociación entre el IG o la CG de la dieta y el GIMC o su cambio al año. Resultados: en la población estudiada no se observó una asociación estadísticamente significativa entre el IG o la CG y el GIMC, ni al inicio ni tras un año de seguimiento.

  5. [In Process Citation].

    PubMed

    Martínez González, Olaia; Vélez de Mendizábal, Itsaso Zabaleta; Galarza Iriarte, Uxue; Vicente Martín, María Soledad; De Vega Castaño, María Del Carmen; Salmerón Egea, Jesús

    2016-03-25

    Introducción: la disfagia o dificultad de deglución afecta a 1 de cada 2 mayores hospitalizados y genera problemas de desnutrición o deshidratación, y aparición de neumonía por aspiración. En situaciones de disfagia orofaríngea, cuando la alimentación oral aún es posible, se deben espesar las texturas líquidas de cara a evitar dichas complicaciones. A los alimentos, tanto fríos como calientes, habitualmente se les añaden espesantes comerciales consistentes en almidones modificados siguiendo especificaciones muy generales que hacen difícil conseguir la textura adaptada a las necesidades personales. Objetivo: el objetivo de este trabajo fue estudiar el efecto de la temperatura del alimento (10 oC y 50 oC), la dosificación (néctar, miel y pudin) y el tiempo transcurrido desde la preparación (0, 3, 5, 10, 20 min) sobre los parámetros de textura de agua espesada a base de uno de los espesantes más ampliamente comercializados. Método: las muestras se analizaron por triplicado en un texturómetro TA.XT2i (Stable Micro Systems, UK) mediante ensayo de compresión-extrusión, empleando una sonda de 2,5 cm de diámetro a una velocidad de 3 mm/s y con una célula de carga de 5 kg. A partir de las curvas fuerza vs. tiempo obtenidas se cuantificaron parámetros indicadores de la firmeza, la adhesividad y el trabajo de las muestras. Resultados y conclusión: en general, los parámetros relacionados con la consistencia fueron significativamente (α < 0,05) superiores en las muestras a mayor temperatura, lo que se puede relacionar con fenómenos incipientes de gelatinización. A su vez, se observó un incremento en los valores de todos los parámetros de textura al aumentar la concentración del espesante y a medida que transcurría el tiempo desde la mezcla de este en el agua. Estos resultados apuntan a la necesidad de realizar un trabajo exhaustivo de caracterización, ampliado también a otros productos y matrices alimentarias, de cara a modelizar la

  6. [In Process Citation].

    PubMed

    Martínez González, Olaia; Vélez de Mendizábal, Itsaso Zabaleta; Galarza Iriarte, Uxue; Vicente Martín, María Soledad; De Vega Castaño, María Del Carmen; Salmerón Egea, Jesús

    2016-01-01

    Introducción: la disfagia o dificultad de deglución afecta a 1 de cada 2 mayores hospitalizados y genera problemas de desnutrición o deshidratación, y aparición de neumonía por aspiración. En situaciones de disfagia orofaríngea, cuando la alimentación oral aún es posible, se deben espesar las texturas líquidas de cara a evitar dichas complicaciones. A los alimentos, tanto fríos como calientes, habitualmente se les añaden espesantes comerciales consistentes en almidones modificados siguiendo especificaciones muy generales que hacen difícil conseguir la textura adaptada a las necesidades personales. Objetivo: el objetivo de este trabajo fue estudiar el efecto de la temperatura del alimento (10 oC y 50 oC), la dosificación (néctar, miel y pudin) y el tiempo transcurrido desde la preparación (0, 3, 5, 10, 20 min) sobre los parámetros de textura de agua espesada a base de uno de los espesantes más ampliamente comercializados. Método: las muestras se analizaron por triplicado en un texturómetro TA.XT2i (Stable Micro Systems, UK) mediante ensayo de compresión-extrusión, empleando una sonda de 2,5 cm de diámetro a una velocidad de 3 mm/s y con una célula de carga de 5 kg. A partir de las curvas fuerza vs. tiempo obtenidas se cuantificaron parámetros indicadores de la firmeza, la adhesividad y el trabajo de las muestras. Resultados y conclusión: en general, los parámetros relacionados con la consistencia fueron significativamente (α < 0,05) superiores en las muestras a mayor temperatura, lo que se puede relacionar con fenómenos incipientes de gelatinización. A su vez, se observó un incremento en los valores de todos los parámetros de textura al aumentar la concentración del espesante y a medida que transcurría el tiempo desde la mezcla de este en el agua. Estos resultados apuntan a la necesidad de realizar un trabajo exhaustivo de caracterización, ampliado también a otros productos y matrices alimentarias, de cara a modelizar la

  7. A nonbreeding concentration of Roseate and Common Terns in Bahia, Brazil

    USGS Publications Warehouse

    Hays, H.; Lima, P.; Monteiro, L.; DiConstanzo, J.; Cormons, G.; Nisbet, I.C.T.; Saliva, J.E.; Spendelow, J.A.; Burger, J.; Pierce, J.; Gochfeld, M.

    1999-01-01

    We report recoveries of banded Roseate (Sterna dougallii) and Common (S. hirundo) Terns netted at Mangue Seco, Bahia, Brazil (11? 27'S, 37? 21'W). Mangue Seco is the first reported South American location where large numbers of Roseate Terns concentrate December-March, and where members of both the North American and Caribbean populations occur together during these months. A Roseate Tern recovered at Mangue Seco sets an age record of 25.6 years for the species. Recoveries at Mangue Seco of Common Terns banded in the Azores (37? -38?N, 25? -29?W) suggest there is a regular transatlantic movement by Common Terns between the two locations.

  8. [Food consumption and the nutritional status of schoolchildren of the Community of Madrid (CAENPE): general methodology and overall food consumption. Consumo de alimentos y estado nutricional de la población escolar].

    PubMed

    Vázquez, C; de Cos, A I; Martínez, P; Jaunsolo, M A; Román, E; Gómez, C; López, T; Hernáez, I; Seijas, V; Ramos, V

    1995-01-01

    The CAENPE study (Food Consumption and Nutritional State of the School Population) was a transversal observational study funded and promoted by the Directorate-General of Food Hygiene in the Ministry of Health, implemented in 1991-93, with the main aim of quantifying food consumption in the school population (6-14 years of age) in the Regional Community of Madrid, together with an anthropometric study and nutritional analysis of that population. This project sets our the General Methodology for the study, paying particular attention to the sampling design, to ensure that the sample is representative of the community, and the results of the overall consumption of food and its comparison with recommended diet and other population studies. Quantification shows a high and rising consumption of meat, meat products, sweets, snacks and prepared dishes, suitable consumption of eggs, legumes and fruit and a notable lack of greens, vegetables and potatoes. The basic results underline the need to introduce educational measures with practical effect on home and school menus.

  9. Escoja Alimentos Sanos y Que Deben Hacer los Padres de los Ninos Que Pesan Mucho. (Food Choices for Good Health and Children and Weight: What's a Parent To Do?).

    ERIC Educational Resources Information Center

    Ikeda, Joanne P.; Mitchell, Rita

    These two publications offer parents information on food choices for children and children's weight. The first publication is a guide that lists, for each of the five food groups, which foods should be eaten often, sometimes, or rarely in order to maintain good health. The food groups are: (1) milk and milk products; (2) meats, poultry, fish,…

  10. 12. DETAIL VIEW OF STRUCTURE, FROM BELOW. VIEW OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. DETAIL VIEW OF STRUCTURE, FROM BELOW. VIEW OF THE PARKER-MAYBERRY BRIDGE AND PART OF THE STRUCTURE OF THE COLORADO STREET BRIDGE, SEEN FROM THE ARROYO SECO BELOW THE COLORADO STREET BRIDGE - Colorado Street Bridge, Spanning Arroyo Seco at Colorado Boulevard, Pasadena, Los Angeles County, CA

  11. New triterpenoids from Gentiana lutea.

    PubMed

    Toriumi, Yoshitaka; Kakuda, Rie; Kikuchi, Masafumi; Yaoita, Yasunori; Kikuchi, Masao

    2003-01-01

    Three new triterpenoids, 2,3-seco-3-oxours-12-en-2-oic acid, 2,3-seco-3-oxoolean-12-en-2-oic acid, and betulin 3-O-palmitate, have been isolated from the rhizomes and roots of Gentiana lutea, together with five known ones. The structures of the new compounds were determined by spectral and chemical methods.

  12. 6. PART 3 OF 3 PART PANORAMA WITH NOS. CA265J4 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. PART 3 OF 3 PART PANORAMA WITH NOS. CA-265-J-4 AND CA-265-J-5 OF FIGUEROA STREET AND LOS ANGELES RIVER VIADUCTS. NOTE ARROYO SECO CHANNEL ENTERING LOS ANGELES RIVER UNDER RAILROAD TRESTLE AT RIGHT. LOOKING 268°W. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

  13. 9. PART 1 OF 2 PART PANORAMA WITH CA265W10 OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. PART 1 OF 2 PART PANORAMA WITH CA-265-W-10 OF YORK BOULEVARD ACCESS ROAD FOR SOUTHBOUND LANES OF ARROYO SECO PARKWAY. NOTE BRIDWELL STREET AT CENTER PARALLEL TO PARKWAY. LOOKING 24°NNE. - Arroyo Seco Parkway, York Boulevard Bridge, Milepost 29.50, Los Angeles, Los Angeles County, CA

  14. 10. PART 2 OF 2 PART PANORAMA WITH CA265W9 OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. PART 2 OF 2 PART PANORAMA WITH CA-265-W-9 OF YORK BOULEVARD ACCESS ROAD FOR SOUTHBOUND LANES OF ARROYO SECO PARKWAY. NOTE SMALL ISLAND FOR EXIT AND ENTRANCE LANES. LOOKING 70°ENE. - Arroyo Seco Parkway, York Boulevard Bridge, Milepost 29.50, Los Angeles, Los Angeles County, CA

  15. New compounds from Commiphora myrrha (Nees) Engl.

    PubMed

    Ahmed, F; Ali, M; Singh, O

    2006-08-01

    Phytochemical investigation of Commiphora myrrha (Nees) Engl. has afforded six new compounds identified as cadina-3-en-15-ol (myrracadinol A) (1), 7, 8-seco-2, 5-dihydroxy-12-acetoxycalam-8-ene (myrracalamene A) (2), 7, 8-seco-2, 3, 5-hydroxy-12-acetoxycalame-8-ene (myrracalamene B) (3), 7, 8-seco-cadin-3, 8-dien-2beta, 12-diol (myrracadinol B) (4), 7, 8-seco-12-hydroxycalam-8-ene (myrracalamene C) (6), 7, 8-seco-cadin-3,7(12)-dien-5alpha,10alpha-diol (myrracadinol C) (7) along with a known compound tria-cont-1-ene (5). Their structures were elucidated on the basis of spectral and chemical analyses.

  16. High-oleic peanuts increase diet-induced thermogenesis in overweight and obese men.

    PubMed

    Duarte Moreira Alves, Raquel; Boroni Moreira, Ana Paula; Silva Macedo, Viviane; Brunoro Costa, Neuza Maria; Gonçalves Alfenas, Rita de Cássia; Bressan, Josefina

    2014-05-01

    Antecedentes: Las pruebas sugieren que el consumo de frutos secos puede mejorar el metabolismo energético. Propósito: Este estudio tenía por finalidad comparar los efectos de la ingesta aguda de cacahuetes con alto contenido en oleico y cacahuetes convencionales sobre el apetito, el consumo de alimentos y el metabolismo energético in hombres con sobrepeso y obesos. Métodos: Se distribuyó a 71 individuos (29,8 ± 2,4 kg/m2) a los grupos: control (CT, n = 24); cacahuetes convencionales (CVP, n = 23); cacahuetes con alto contenido en oleico (HOP, n = 24). Los individuos consumieron 56 g de cacahuetes (CVP y HOP) o control (CT) tras un ayuno nocturno. Posteriormente, se evaluó el metabolismo energético a lo largo de 200 minutes, durante los cuales se analizaron la termogénesis inducida por la dieta (TID) y la oxidación de sustratos. La sensación de apetito se registró durante 3 horas. Se realizaron los análisis estadísticos con el programa SAS considerando un nivel de significación del 5%. Resultados: El consumo de energía posprandial y la TID fueron significativamente superiores en el HOP que el CVP. La oxidación de sustratos no difirió entre los grupos. Sólo el HOP presentó una puntuación por debajo de 100, lo que indicaba una compensación incompleta. El CT y el CVP mostraron una compensación calórica completa (puntuaciones > 100). Con respecto a la sensación de apetito, el grupo CVP se mostró menos “lleno” que los grupos HOP y CT. A las 3 horas, la puntuación de saciedad del CVP volvió a la situación basal, mientras que en los grupos HOP y CT permanecía significativamente superior. Las puntuaciones de hambre volvieron a la situación basal in los grupos CVP y CT y se mantuvieron significativamente por debajo a las del grupo HOP. Conclusión: Los cacahuetes con alto contenido en oleico contribuyen a una mayor TID, mayor sensación de plenitud y una compensation incompleta del consumo de energía en comparación con los cacahuetes

  17. [Adherence to the Mediterranean diet and its relation to nutritional status in older people].

    PubMed

    Zaragoza Martí, Ana; Ferrer Cascales, Rosario; Cabañero Martínez, María José; Hurtado Sánchez, Jose Antonio; Laguna Pérez, Ana

    2015-04-01

    Introducción: la Dieta Mediterránea (DM) como modelo de dieta de calidad se asocia con una reducción de la mortalidad y con una mejora en la calidad de vida en personas mayores. Objetivo: evaluar la relación entre el estado nutricional y los estilos de vida con el grado de adherencia a la DM en personas mayores Métodos: Muestra compuesta por 60 sujetos que acudían a la consulta de enfermería de un cetro de salud de Alicante con un Índice de Masa Corporal mayor a 24.9. Se utilizó el cuestionario de frecuencia de consumo de alimentos MEDIS-FFQ, el cuestionario de adherencia a la Dieta Mediterránea PREDIMED y la valoración antropométrica. Resultados: El 83.3% de la población presentó sobrepeso frente a un 16.7% de obesidad, sin diferencias significativas entre sexos. El porcentaje de grasa corporal fue del 40.3% en las mujeres y 29.5% en los hombres (p=0.001). El 65.2% de la mujeres presentó riesgo cardiovascular frente al 81.8% de los hombres (p=0.001). Se observó bajo cumplimento de las recomendaciones alimentarias en los cereales integrales, fruta y frutos secos. Los sujetos con baja adherencia a la DM presentaron mayores índices de obesidad (OR= 1.46; IC 95%, 0.89-2.40), un mayor consumo de tabaco (OR= 1.65; IC 95%, 1.05-2.60) y de alcohol (OR=1.53; IC 95%, 0.91-2.55), un mayor índice cintura-cadera (OR= 2.57; IC 95%, 1.3-4.9) y mayor porcentaje de grasa corporal (OR= 5.3; IC 95%, 1.02-6.48). Conclusión: Los sujetos con una buena adherencia a la (DM) presentaron un menor índice cintura-cadera y un menor porcentaje de grasa corporal.

  18. [Quality of the diet of the Spanish population over 80 years non-institutionalized].

    PubMed

    Hernández Galiot, Ana; Goñi Cambrodón, Isabel

    2015-06-01

    Introducción: los adultos mayores no institucionalizados son un colectivo que suele presentar alto riesgo de malnutrición. Detectar problemas nutricionales mediante indicadores de la calidad global de la dieta, es un reto para los profesionales de la salud, de utilidad para la planificación de políticas nutricionales. Objetivo: determinar la calidad global de la dieta de la población española mayor de 80 años no institucionalizada, para promover y fomentar la calidad de vida del anciano. Metodología: se seleccionaron las personas mayores de 80 años del Estudio Longitudinal Envejecer en España 2011-2013 (n = 159), residentes en diversas zonas españolas. Para valorar la calidad de la dieta se utilizó el índice de alimentación saludable (IAS), la frecuencia de consumo de alimentos y el grado de adhesión al patrón de dieta Mediterránea (ADM). Resultados: la población presentó valores de IAS cercanos a los correspondientes a una dieta saludable. Un porcentaje significativo necesitaba cambios en su alimentación, siendo los mayores de 90 años los que requirieron una mayor intervención dietética. La mayoría de la población cumplió las recomendaciones de la dieta mediterránea, aunque se observó bajo consumo de verduras, hortalizas, frutos secos y vino; y elevado consumo de embutidos. Conclusiones: la dieta consumida habitualmente por los españoles mayores de 80 años no institucionalizados presenta desajustes nutricionales que podrían corregirse realizando pequeños cambios en su patrón dietético. Determinar la calidad global de la dieta permite la planificación de estrategias de intervención para promover cambios alimentarios saludables y emprender acciones orientadas al mantenimiento de una salud óptima en el binomio envejecimiento-nutrición.

  19. [Not Available].

    PubMed

    Navarro-González, Inmaculada; Ros, Gaspar; Martínez-García, Brígida; Rodríguez-Tadeo, Alejandra; Periago, M Jesús

    2016-07-19

    Introducción y objetivos: la evolución que ha experimentado en los últimos años la sociedad española ha originado una serie de cambios sociológicos y/o culturales que afectan claramente a los hábitos y preferencias alimentarias. El objetivo del presente trabajo ha sido evaluar la adherencia a la dieta mediterránea (DM) de la población universitaria en la ciudad de Murcia y la calidad de su desayuno, estableciendo la relación existente entre estas dos variables entre sí, y otras variables sociológicas analizadas.Métodos: se evaluó la adherencia a la DM en una muestra de 312 estudiantes mediante el test KIDMED, cuestionario de 16 preguntas. La calidad del desayuno fue determinada en función de la ingesta de los distintos grupos de alimentos (lácteos, cereales y frutas), de forma que se establecieron las siguientes categorías de calidad: pésima, mala, regular y buena. De cada encuestado se registraron los datos personales, lugar de origen, zona geográfica y tipo de residencia, sexo, edad, titulación universitaria, curso y las variables antropométricas (peso, altura, perímetro de cintura y cadera).Resultados: la muestra estuvo formada por 238 mujeres y 74 hombres todos ellos estudiantes universitarios de distintos títulos de grado. El 7,85% de los universitarios mostró una baja adherencia a la DM, el 48,4% media y el 43,8% alta. Los estudiantes de grado en Educación Primaria mostraron una mayor adherencia media a la DM; los estudiantes de grado en Enfermería tomaron más de una ración de verdura al día; y los de Ciencia y Tecnología de los Alimentos consumían una pieza de fruta al día. Teniendo en cuenta el sexo de los participantes, el 37,8% de las mujeres tomaban más de una verdura diaria y el 91,5% desayunaba bollería industrial; mientras que el 54,1% de los hombres tomaban frutos secos (al menos 2 o 3 veces por semana) y el 74,5% desayunaba todos los días. El 1,15% de los estudiantes mostró una calidad del desayuno pésima, el 17

  20. [Not Available].

    PubMed

    Navarro-González, Inmaculada; Ros, Gaspar; Martínez-García, Brígida; Rodríguez-Tadeo, Alejandra; Periago, M Jesús

    2016-01-01

    Introducción y objetivos: la evolución que ha experimentado en los últimos años la sociedad española ha originado una serie de cambios sociológicos y/o culturales que afectan claramente a los hábitos y preferencias alimentarias. El objetivo del presente trabajo ha sido evaluar la adherencia a la dieta mediterránea (DM) de la población universitaria en la ciudad de Murcia y la calidad de su desayuno, estableciendo la relación existente entre estas dos variables entre sí, y otras variables sociológicas analizadas.Métodos: se evaluó la adherencia a la DM en una muestra de 312 estudiantes mediante el test KIDMED, cuestionario de 16 preguntas. La calidad del desayuno fue determinada en función de la ingesta de los distintos grupos de alimentos (lácteos, cereales y frutas), de forma que se establecieron las siguientes categorías de calidad: pésima, mala, regular y buena. De cada encuestado se registraron los datos personales, lugar de origen, zona geográfica y tipo de residencia, sexo, edad, titulación universitaria, curso y las variables antropométricas (peso, altura, perímetro de cintura y cadera).Resultados: la muestra estuvo formada por 238 mujeres y 74 hombres todos ellos estudiantes universitarios de distintos títulos de grado. El 7,85% de los universitarios mostró una baja adherencia a la DM, el 48,4% media y el 43,8% alta. Los estudiantes de grado en Educación Primaria mostraron una mayor adherencia media a la DM; los estudiantes de grado en Enfermería tomaron más de una ración de verdura al día; y los de Ciencia y Tecnología de los Alimentos consumían una pieza de fruta al día. Teniendo en cuenta el sexo de los participantes, el 37,8% de las mujeres tomaban más de una verdura diaria y el 91,5% desayunaba bollería industrial; mientras que el 54,1% de los hombres tomaban frutos secos (al menos 2 o 3 veces por semana) y el 74,5% desayunaba todos los días. El 1,15% de los estudiantes mostró una calidad del desayuno pésima, el 17

  1. Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons.

    PubMed

    Sathishkumar, K; Murthy, Subramanyam N; Uppu, Rao M

    2007-01-01

    Ozone present in the photochemical smog or generated at the inflammatory sites is known to oxidize cholesterol and its 3-acyl esters. The oxidation results in the formation of multiple "ozone-specific" oxysterols, some of which are known to cause abnormalities in the metabolism of cholesterol and exert cytotoxicity. The ozone-specific oxysterols have been shown to favor the formation of atherosclerotic plaques and amyloid fibrils involving pro-oxidant processes. In the present communication, cultured murine GT1-7 hypothalamic neurons were studied in the context of cholesterol metabolism, formation of reactive oxygen species, intracellular Ca2 + levels and cytotoxicity using two most commonly occurring cholesterol ozonolysis products, 3beta- hydroxy-5-oxo-5,6-secocholestan-6-al (ChSeco) and 5beta, 6beta-epoxy-cholesterol (ChEpo). It was found that ChSeco elicited cytotoxicity at lower concentration (IC50 = 21 +/- 2.4 microM) than did ChEpo (IC50 = 43 +/- 3.7 microM). When tested at their IC50 concentrations in GT1-7 cells, both ChSeco and ChEpo resulted in the generation of ROS, the magnitude of which was comparable. N-acetyl-l-cysteine and Trolox attenuated the cytotoxic effects of ChSeco and ChEpo. The intracellular Ca2 + levels were not altered by either ChSeco or ChEpo. Methyl-beta-cyclodextrins, which cause depletion of cellular cholesterol, prevented ChSeco- but not ChEpo-induced cytotoxicity. The cell death caused by ChEpo, but not ChSeco, was prevented by exogenous cholesterol. Although oxidative stress plays a significant role, the results of the present study indicate differences in the pathways of cell death induced by ChSeco and ChEpo in murine GT1-7 hypothalamic neurons. PMID:17164181

  2. Space telescope optical telescope assembly/scientific instruments. Phase B: Preliminary design and program definition study. Volume 2A. focal plane camera

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Trade studies were conducted to ensure the overall feasibility of the focal plane camera in a radial module. The primary variable in the trade studies was the location of the pickoff mirror, on axis versus off-axis. Two alternatives were: (1) the standard (electromagnetic focus) SECO submodule, and (2) the MOD 15 permanent magnet focus SECO submodule. The technical areas of concern were the packaging affected parameters of thermal dissipation, focal plane obscuration, and image quality.

  3. AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG.

    PubMed

    Hosseinian, Farah S; Muir, Alister D; Westcott, Neil D; Krol, Ed S

    2007-02-21

    Secoisolariciresinol (SECO ) is the major lignan found in flaxseed (Linum usitatissimum L.) and is present in a polymer that contains secoisolariciresinol diglucoside (SDG ). SECO, SDG and the polymer are known to have a number of health benefits, including reduction of serum cholesterol levels, delay in the onset of type II diabetes and decreased formation of breast, prostate and colon cancers. The health benefits of SECO and SDG may be partially attributed to their antioxidant properties. To better understand their antioxidant properties, SECO and SDG were oxidized using 2,2'-azobis(2-amidinopropane), an in vitro model of radical scavenging. The major lignan radical-scavenging oxidation products and their formation over time were determined. SDG was converted to four major products, which were the result of a phenoxyl radical intermediate. One of these products, a dimer of SDG, decomposed under the reaction conditions to form two of the other major products, and . SECO was converted to five major products, two of which were also the result of a phenoxyl radical intermediate. The remaining products were the result of an unexpected alkoxyl radical intermediate. The phenol oxidation products were stable under the reaction conditions, whereas two of the alcohol oxidation products decomposed. In general, only one phenol group on the lignans was oxidized, suggesting that the number of phenols per molecule may not predict radical scavenging antioxidant ability of lignans. Finally, SECO is a superior antioxidant to SDG, and it may be that the additional alcohol oxidation pathway contributes to its greater antioxidant ability.

  4. Structures and biological activities of triterpenes and sesquiterpenes obtained from Russula lepida.

    PubMed

    Lee, Jong-Soo; Maarisit, Wilmar; Abdjul, Delfly B; Yamazaki, Hiroyuki; Takahashi, Ohgi; Kirikoshi, Ryota; Kanno, Syu-Ichi; Namikoshi, Michio

    2016-07-01

    A seco-cucurbitane triterpene and two aristolane sesquiterpenes, named (24E)-3,4-seco-cucurbita-4,24-diene-3-hydroxy-26,29-dioic acid, (+)-1,2-didehydro-9-hydroxy-aristlone, and (+)-12-hydroxy-aristlone, were isolated from fruiting bodies of the medicinal mushroom Russula lepida, together with (24E)-3,4-seco-cucurbita-4,24-diene-3,26,29-trioic acid and (+)-aristlone. The structures of the first three compounds, including their absolute configurations, were assigned on the basis of their NMR and ECD spectra. Two seco-cucurbitane triterpenes, (24E)-3,4-seco-cucurbita-4,24-diene-3-hydroxy-26,29-dioic acid and (24E)-3,4-seco-cucurbita-4,24-diene-3,26,29-trioic acid, inhibited the activity of protein tyrosine phosphatase 1B (PTP1B), with IC50 values of 20.3 and 0.4μM, respectively. All isolated compounds did not show cytotoxicity against human cancer cell lines, Huh-7 (hepatoma) and EJ-1 (bladder), at 50μM. PMID:27066716

  5. [Bioimpedance vector analysis as a tool for the determination and adjustment of dry weight in patients undergoing hemodialysis].

    PubMed

    Atilano-Carsi, Ximena; Miguel, José Luis; Martínez Ara, Jorge; Sánchez Villanueva, Rafael; González García, Elena; Selgas Gutiérrez, Rafael

    2015-05-01

    Antecedentes y objetivo: La sobrehidratación en los pacientes en hemodiálisis se asocia con mortalidad cardiovascular, por lo que la adecuada remoción de líquidos y el logro del peso seco es uno de los principales objetivos de la terapia. Hasta el momento no hay parámetros clínicos ni de laboratorio que sean confiables, sencillos y accesibles para su determinación. El análisis de vectores de impedancia (VIBE) es una herramienta que permite identificar y monitorizar el estado de hidratación, por lo que el objetivo de este estudio fue usar el VIBE para ajustar la intensidad del ultrafiltrado y alcanzar el peso seco en pacientes en hemodiálisis. Material y método: Se estudiaron 26 pacientes en hemodiálisis a los cuales se les realizaron medidas mensuales de impedancia bioeléctrica durante cuatro meses. Se graficaron los vectores correspondientes para conocer de manera individual el estado de hidratación, de acuerdo con lo cual se ajustó el peso seco en los casos necesarios. Resultados: Se realizó ajuste de peso seco en 13 pacientes, 7 de ellos necesitaron aumento de peso y 6 disminución del mismo. El desplazamiento de los vectores sobre las elipses correspondió al tipo de intervención realizada. Se logró alcanzar el peso seco en el 84.6% de los pacientes al final del estudio, con una disminución significativa de la presión arterial media y aumento del ángulo de fase en el grupo de disminución de peso seco. Conclusiones: El análisis de vectores de impedancia es útil para el ajuste del peso seco en los pacientes sometidos a hemodiálisis.

  6. Energia Renovable para Centros de Salud Rurales (Renewable Energy for Rural Health Clinics)

    SciTech Connect

    Jimenez, T.; Olson, K.

    1999-07-28

    Esta es la primera de una serie de guias de aplicaciones que el Programa de Energia de Villas de NREL esta comisionando para acoplar sistemas comerciales renovables con aplicaciones rurales, incluyendo agua, escuelas rurales y micro empresas. La guia esta complementada por las actividades de desarrollo del Programa de Energia de Villas de NREL, proyectos pilotos internacionales y programas de visitas profesionales.

  7. Triterpenes from the exudate of Gardenia urvillei.

    PubMed

    Mai, Hoang Linh; Grellier, Philippe; Prost, Elise; Lemoine, Pascale; Poullain, Cyril; Dumontet, Vincent; Deguin, Brigitte; Vo, Thi Bach Hue; Michel, Sylvie; Grougnet, Raphaël

    2016-02-01

    A cycloartane gardurvilleic acid, three 3,4-seco-cycloartanes securvienol, secodienurvilleic acid, securvitriol, a 3,4;9,10-seco-cycloartane gardheptlactone, two dammaranes urvilone, urvilol, along with eight known cycloartanes and 3,4-seco-cycloartanes and four known dammaranes have been isolated from the bud exudate of Gardenia urvillei, an endemic tree to the New Caledonian dry forest. Two other dammarane derivatives have been obtained by semisynthesis. The structures of the original compounds were determined by spectroscopic methods and chemical correlations. In association with previously published data, the description of oxidized side-chains in position 17 are now available for two couples of diastereoisomers. Evaluation of anti-parasite activity and cytotoxicity has shown noticeable results for some of the isolated triterpenes. PMID:26608669

  8. 6. SITE OVERVIEW. PART 1 OF 6 PART PANORAMA WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. SITE OVERVIEW. PART 1 OF 6 PART PANORAMA WITH NOS. CA-265-7 TO CA-265-11. ARROYO SECO PARKWAY AS SEEN FROM RADIO TOWER HILL (APPROXIMATELY 34° 5' BY 118° 12'30" ON USGS LOS ANGELES QUADRANGLE). PART 1 SHOWS GRAND VIEW POINT AT RIGHT REAR (LOCATION OF CAMERA POSITION FOR PHOTOGRAPHS NOS. 265-1 TO CA-265-5) AND FIGUEROA VIADUCT OVERCROSSING; DOWNTOWN LOS ANGELES IS AT LEFT REAR. LOOKING 234° SW. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  9. Cataract Vision Simulator

    MedlinePlus

    ... and Latino-Americans Apr 26, 2016 Vitamin See: Foods Rich in Vitamin C Help Curb Cataracts Mar 28, 2016 Los Alimentos Ricos en ... at the Academy Financial Relationships with Industry Medical Disclaimer Privacy Policy Terms of Service For ...

  10. Hemophilia Treatments Have Come a Long Way

    MedlinePlus

    ... blood. Today, an increasing number are made using recombinant DNA technology (a form of artificial DNA), with ... Medical Devices Nutrition Radiation-Emitting Products Tobacco Products Vaccines, Blood & Biologics Articulos en Espanol Alimentos y Bebidas ...

  11. IOL Implants: Lens Replacement and Cataract Surgery (Intraocular Lenses)

    MedlinePlus

    ... by: Kierstan Boyd Reviewed by: Elizabeth Yeu MD Mar. 01, 2016 Before intraocular lenses (IOLs) were developed, ... Foods Rich in Vitamin C Help Curb Cataracts Mar 28, 2016 Los Alimentos Ricos en Vitamina C ...

  12. 77 FR 76625 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ...) (``IEEPA''), issued Executive Order 12978 (60 FR 54579, October 24, 1995) (the ``Order''). In the Order.... 36175880 (Colombia) (individual) . 5. SANCHEZ CONDE, Martha Cecilia, c/o ALIMENTOS CARNICOS DE...

  13. [Design and validation of a questionnaire to assess dietary behavior in Mexican students in the area of health].

    PubMed

    Márquez-Sandoval, Yolanda Fabiola; Salazar-Ruiz, Erika Nohemi; Macedo-Ojeda, Gabriela; Altamirano-Martínez, Macedo-Ojeda; Bernal-Orozco, María Fernanda; Salas-Salvadó, Jordi; Vizmanos-Lamotte, Barbara

    2014-07-01

    INTRODUCCIÓN: El comportamiento alimentario (CA), que establece la relación del ser humano con los alimentos, influye en el consumo de nutrimentos y por tanto contribuye al estado de salud o enfermedad de la población, incluso en jóvenes universitarios. Existen algunos instrumentos validados para evaluar el consumo de alimentos y nutrimentos, pero son escasos los que valoran el CA.

  14. Consumption of functional foods in Europe; a systematic review.

    PubMed

    Özen, Asli E; Bibiloni, María del Mar; Pons, Antoni; Tur, Josep A

    2014-03-01

    Objetivo: Evaluar las diferencias en el consumo de alimentos funcionales entre los países europeos. Diseño: Revisión sistemática. La búsqueda bibliográfica se realizó en Medlars Online International Literature (MEDLINE), vía PubMed©, y Scopus. Se identificaron veintidós estudios que examinaron las diferencias en el consumo de alimentos funcionales entre los europeos. Resultados: Existen diferencias en la proporción de consumidores de alimentos funcionales entre los países europeos. Así, mientras los alimentos funcionales son muy populares en la mayoría de los países europeos como Finlandia, Suecia, Países Bajos, Polonia, España y Chipre, en algunos países como Dinamarca, Italia y Bélgica no lo son tanto. Un elevado porcentaje de adolescentes europeos mediterráneos (España y Chipre, pero no Italia) consume alimentos funcionales. La evaluación del consumo de alimentos funcionales en función del género es difícil, pues los resultados varían de estudio a estudio. Conclusiones: En los últimos años se ha extendido el consumo de alimentos funcionales en Europa, pero dicho consumo muestra grandes diferencias entre los europeos. Más investigaciones serán necesarias para averiguar las razones subyacentes tras estas diferencias y entender las necesidades de los consumidores de alimentos funcionales.

  15. [The healthy eating index of new students at an university of Mexico].

    PubMed

    Muñoz-Cano, Juan Manuel; Córdova-Hernández, Juan Antonio; del Valle-Leveaga, David

    2015-04-01

    Introducción: El principal factor asociado al incremento de la prevalencia de enfermedades no transmisibles es el consumo de alimentos industrializados modernos. Objetivo: Evaluar la calidad de la dieta de estudiantes de nuevo ingreso. Métodos: Se colectaron datos de 3550 estudiantes con edad  18.65 años mediante un cuestionario de frecuencia de consumo de alimentos. Se evaluaron con diez variables que se calificaron en tres categorías: saludable, necesita cambios y poco saludable. Se compararon los resultados de los de ciencias de la salud con los otros campus. Resultados: Hubo disminución del consumo de alimentos que deberían ser diario como cereales integrales, verduras y frutas. Se encontró incremento de alimentos que deberían ser de consumo ocasional a al menos 1 a 2 por semana. Los puntajes del índice de alimentación saludable fueron 80.2% en la categoría “poco saludable”, 19.7% en “necesita cambios” y 0.1% en “saludable”. Conclusiones: Los resultados son consecuencia de la disminución del consumo de alimentos de la dieta tradicional de Mesoamérica. No se encontró efecto de la selección de campus con el patrón de consumo de alimentos.

  16. Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea.

    PubMed

    Kiem, Phan Van; Minh, Chau Van; Nhiem, Nguyen Xuan; Cuc, Nguyen Thi; Quang, Ngo Van; Tuan Anh, Hoang Le; Tai, Bui Huu; Yen, Pham Hai; Hoai, Nguyen Thi; Ho, Kim Young; Kim, Nanyoung; Park, SeonJu; Kim, Seung Hyun

    2014-01-01

    Seven new muurolane-type sesquiterpenes, (4R,5R)-muurol-1(6),10(14)-diene-4,5-diol (1), (4R,5R)-muurol-1(6)-ene-4,5-diol (2), (4R,5R,10R)-10-methoxymuurol-1(6)-ene-4,5-diol (3), (4S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10-dione (4), (4R)-4-hydroxy-1,10-seco-muurol-5-ene-1,10-dione (5), (6S,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (6), and (6R,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (7) were isolated from the marine sponge Dysidea cinerea. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-NMR, 2D-NMR, and CD spectra as well as by comparing the NMR data with those reported in the literature.

  17. 8. FIGUEROA STREET TUNNEL NO. 2, SOUTH PORTAL SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. FIGUEROA STREET TUNNEL NO. 2, SOUTH PORTAL SEEN FROM ABOVE NORTH PORTAL OF TUNNEL NO. 3. LOOKING 12°N. - Figueroa Street Tunnels, Mileposts 24.90, 25.14, 25.28, & 25.37 on Arroyo Seco Parkway, Los Angeles, Los Angeles County, CA

  18. 12. FIGUEROA STREET TUNNEL NO.1, SOUTH PORTAL.SEEN FROM ABOVE NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. FIGUEROA STREET TUNNEL NO.1, SOUTH PORTAL.SEEN FROM ABOVE NORTH PORTAL OF TUNNEL NO. 2. LOOKING 140N. - Figueroa Street Tunnels, Mileposts 24.90, 25.14, 25.28, & 25.37 on Arroyo Seco Parkway, Los Angeles, Los Angeles County, CA

  19. New diterpenes from the heartwood of Chamaecyparis obtusa var. formosana.

    PubMed

    Kuo, Y H; Chen, C H; Huang, S L

    1998-06-26

    An abietane diterpene, 11,14-dihydroxy-8,11,13-abietatrien-7-one (1); a seco-abietane diterpene, obtuanhydride (2); and an isopimarane diterpene, 18,19-O-isopropylidene-18, 19-dihydroxyisopimara-8(14),15-diene (3) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structures of these new compounds were elucidated by spectroscopic methods. PMID:9644078

  20. Involvement of Extracellular Cu/Zn Superoxide Dismutase in Cotton Fiber Primary and Secondary Cell Wall Biosynthesis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Extracellular Cu/Zn superoxide dismutases (CSDs) that catalyze the conversion of superoxide to hydrogen peroxide have been suggested to be involved in lignification of secondary walls in spinach, pine and aspen. In cotton fibers, hydrogen peroxide was proposed to be involved in the induction of seco...

  1. 10. DETAIL VIEW OF UNDERSIDE OF FIGUEROA STREET VIADUCT SEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. DETAIL VIEW OF UNDERSIDE OF FIGUEROA STREET VIADUCT SEEN FROM SAN FERNANDO ROAD. NOTE THAT GLOBE OF LAMP FIXTURE APPEARS TO HAVE MELTED. LOOKING 206°SSW. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

  2. SERS detection of indirect viral DNA capture using colloidal gold and methylene blue as a Raman label

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An indirect capture model assay using colloidal Au nanoparticles is demonstrated for surface enhanced Raman scattering (SERS) spectroscopy detection of DNA. The sequence targeted for capture is derived from the West Nile Virus (WNV) RNA genome and was selected on the basis of exhibiting minimal seco...

  3. Aflatoxinas

    Cancer.gov

    Las aflatoxinas son un tipo de toxinas producidas por ciertos hongos en cultivos agrícolas como el maíz, los cacahuates o el maní, la semilla de algodón y los frutos secos (de cáscara dura como las nueces).

  4. 5. PART 2 OF 3 PART PANORAMA WITH NOS. CA265J4 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. PART 2 OF 3 PART PANORAMA WITH NOS. CA-265-J-4 AND CA-265-J-6 OF FIGUEROA STREET AND LOS ANGELES RIVER VIADUCTS. LOOKING 308°W. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

  5. 4. PART 1 OF 3 PART PANORAMA WITH NOS. CA265J5 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. PART 1 OF 3 PART PANORAMA WITH NOS. CA-265-J-5 AND CA-265-J-6 OF FIGUEROA STREET AND LOS ANGELES RIVER VIADUCTS. NOTE TUNNEL NO.1 NORTH PORTAL AT LEFT REAR. LOOKING 268°W. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

  6. SOLANO AVENUE ENTRANCE RAMP. NOTE SOLANO AVENUE OVERCROSSING AT LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOLANO AVENUE ENTRANCE RAMP. NOTE SOLANO AVENUE OVERCROSSING AT LEFT REAR AND CLOSED ACCESS RAMP BENEATH; PARK ROW BRIDGE AT CENTER REAR AND TUNNEL NO. 2. LOOKING 350°N - Arroyo Seco Parkway, Solano Avenue Underpass, Milepost 25.09, Los Angeles, Los Angeles County, CA

  7. 9. ACCESS ROAD FOR NORTHBOUND PARKWAY LANES AT AVENUE 60. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. ACCESS ROAD FOR NORTHBOUND PARKWAY LANES AT AVENUE 60. NOTE RAILING AT LEFT FOR BRIDGE SEEN IN CA-265-T-8. LOOKING 308°N. - Arroyo Seco Parkway, Avenue 60 Bridge, Milepost 28.76, Los Angeles, Los Angeles County, CA

  8. 3. REAR OF NORTH PORTAL TUNNEL NO.4. PART 1 OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. REAR OF NORTH PORTAL TUNNEL NO.4. PART 1 OF 2 PART PANORAMA WITH PHOTOGRAPH CA-265-G-2-b. NOTE CONSTRUCTION MATERIALS FOR FREEWAY WIDENING OF HILL STREET EXIT. LOOKING 2°N. - Figueroa Street Tunnels, Mileposts 24.90, 25.14, 25.28, & 25.37 on Arroyo Seco Parkway, Los Angeles, Los Angeles County, CA

  9. Spectrally Enhanced Cloud Objects—A generalized framework for automated detection of volcanic ash and dust clouds using passive satellite measurements: 1. Multispectral analysis

    NASA Astrophysics Data System (ADS)

    Pavolonis, Michael J.; Sieglaff, Justin; Cintineo, John

    2015-08-01

    While satellites are a proven resource for detecting and tracking volcanic ash and dust clouds, existing algorithms for automatically detecting volcanic ash and dust either exhibit poor overall skill or can only be applied to a limited number of sensors and/or geographic regions. As such, existing techniques are not optimized for use in real-time applications like volcanic eruption alerting and data assimilation. In an effort to significantly improve upon existing capabilities, the Spectrally Enhanced Cloud Objects (SECO) algorithm was developed. The SECO algorithm utilizes a combination of radiative transfer theory, a statistical model, and image processing techniques to identify volcanic ash and dust clouds in satellite imagery with a very low false alarm rate. This fully automated technique is globally applicable (day and night) and can be adapted to a wide range of low earth orbit and geostationary satellite sensors or even combinations of satellite sensors. The SECO algorithm consists of four primary components: conversion of satellite measurements into robust spectral metrics, application of a Bayesian method to estimate the probability that a given satellite pixel contains volcanic ash and/or dust, construction of cloud objects, and the selection of cloud objects deemed to have the physical attributes consistent with volcanic ash and/or dust clouds. The first two components of the SECO algorithm are described in this paper, while the final two components are described in a companion paper.

  10. Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats.

    PubMed

    Mukker, Jatinder Kaur; Singh, Ravi Shankar Prasad; Muir, Alister D; Krol, Ed S; Alcorn, Jane

    2015-03-14

    Consumption of flaxseed lignans is associated with various health benefits; however, little is known about the bioavailability of purified lignans in flaxseed. Data on their bioavailability and hence pharmacokinetics (PK) are necessary to better understand their role in putative health benefits. In the present study, we conducted a comparative PK analysis of the principal lignan of flaxseed, secoisolariciresinol diglucoside (SDG), and its primary metabolites, secoisolariciresinol (SECO), enterodiol (ED) and enterolactone (EL) in rats. Purified lignans were intravenously or orally administered to each male Wistar rat. SDG and its primary metabolites SECO, ED and EL were administered orally at doses of 40, 40, 10 and 10 mg/kg, respectively, and intravenously at doses of 20, 20, 5 and 1 mg/kg, respectively. Blood samples were collected at 0 (pre-dose), 5, 10, 15, 20, 30 and 45 min, and at 1, 2, 4, 6, 8, 12 and 24 h post-dosing, and serum samples were analysed. PK parameters and oral bioavailability of purified lignans were determined by non-compartmental methods. In general, administration of the flaxseed lignans SDG, SECO and ED demonstrated a high systemic clearance, a large volume of distribution and short half-lives, whereas administration of EL at the doses of 1 mg/kg (intravenously) and 10 mg/kg (orally administered) killed the rats within a few hours of dosing, precluding a PK analysis of this lignan. PK parameters of flaxseed lignans exhibited the following order: systemic clearance, SDG < SECO < ED; volume of distribution, SDG < SECO < ED; half-life, SDG < ED < SECO. The percentage of oral bioavailability was 0, 25 and < 1 % for SDG, SECO and ED, respectively.

  11. [In Process Citation].

    PubMed

    Menal-Puey, Susana; Morán Del Ruste, Manuel; Marques-Lopes, Iva

    2016-03-25

    Introducción: una dieta vegetariana puede satisfacer las necesidades nutricionales si está bien planificada. En este sentido, los vegetarianos deben ser aconsejados para elegir alimentos alternativos a los productos de origen animal seleccionando el tamaño de porción adecuada de cada uno de ellos. El valor nutricional de las porciones de los alimentos vegetales tradicionales es bien conocido, sin embargo, el mercado vegetariano ofrece otros productos cuya composición química es menos conocida, ya que no son alimentos ampliamente consumidos por la población. Es necesario conocer tanto el contenido de nutrientes de las porciones de estos alimentos como la biodisponibilidad de estos nutrientes en la dieta vegetariana. Objetivos: este trabajo tiene como objetivo mejorar la información disponible sobre el aporte nutricional a la dieta de un adulto sano de las porciones de alimentos utilizados por la población vegetariana. Además, se discuten algunos puntos sobre la biodisponibilidad de los nutrientes más relevantes, y se proponen alternativas para mejorar su utilización. Métodos: los datos de composición de los alimentos veganos, por 100 g, se buscaron en bases de datos de composición de alimentos, y a partir de ellos se calculó la composición química de las porciones. Después, estos datos nutricionales se compararon con las ingestas dietéticas de referencia europeas para la población adulta, y se discutió la biodisponibilidad de los nutrientes más importantes.

  12. [In Process Citation].

    PubMed

    Menal-Puey, Susana; Morán Del Ruste, Manuel; Marques-Lopes, Iva

    2016-01-01

    Introducción: una dieta vegetariana puede satisfacer las necesidades nutricionales si está bien planificada. En este sentido, los vegetarianos deben ser aconsejados para elegir alimentos alternativos a los productos de origen animal seleccionando el tamaño de porción adecuada de cada uno de ellos. El valor nutricional de las porciones de los alimentos vegetales tradicionales es bien conocido, sin embargo, el mercado vegetariano ofrece otros productos cuya composición química es menos conocida, ya que no son alimentos ampliamente consumidos por la población. Es necesario conocer tanto el contenido de nutrientes de las porciones de estos alimentos como la biodisponibilidad de estos nutrientes en la dieta vegetariana. Objetivos: este trabajo tiene como objetivo mejorar la información disponible sobre el aporte nutricional a la dieta de un adulto sano de las porciones de alimentos utilizados por la población vegetariana. Además, se discuten algunos puntos sobre la biodisponibilidad de los nutrientes más relevantes, y se proponen alternativas para mejorar su utilización. Métodos: los datos de composición de los alimentos veganos, por 100 g, se buscaron en bases de datos de composición de alimentos, y a partir de ellos se calculó la composición química de las porciones. Después, estos datos nutricionales se compararon con las ingestas dietéticas de referencia europeas para la población adulta, y se discutió la biodisponibilidad de los nutrientes más importantes. PMID:27238802

  13. Software application for the calculation of dietary intake of individual carotenoids and of its contribution to vitamin A intake.

    PubMed

    Estévez-Santiago, Rocío; Beltrán-de-Miguel, Beatriz; Cuadrado-Vives, Carmen; Olmedilla-Alonso, Begoña

    2013-01-01

    Introducción: Las aplicaciones informáticas utilizadas para valorar la ingesta dietética suelen centrarse en macro y micronutrientes, pero no en otros componentes de la dieta con potenciales efectos beneficiosos sobre la salud, entre los que están los carotenoides. El grado en que cada carotenoide ejerce diversas actividades biológicas es diferente y por tanto, interesa utilizar datos de su composición en alimentos de forma individualizada. Objetivo: Elaborar una aplicación informática con datos individualizados de carotenoides que permita el cálculo de su ingesta dietética y la consulta del contenido de estos compuestos en los alimentos. Material y métodos: Aplicación informática desarrollada con Java 7, que incluye una base de datos de carotenoides (luteína, zeaxantina, licopeno, ?-criptoxantina, ?- caroteno y ?-caroteno) en alimentos (incluyendo aquellos que son principales contribuyentes a la ingesta de carotenoides en Europa), generados por HPLC. Se incluyen las variables relativas a los alimentos, sujetos y dietas, que son necesarias para una correcta información del contenido de carotenoides en alimentos y para el cálculo de su ingesta. Resultados: La aplicación informática permite calcular la ingesta dietética individualizada de carotenoides, a partir de 128 alimentos (crudos y cocinados) y su contribución a la ingesta de vitamina A, en las dos formas utilizadas actualmente, equivalentes de retinol y equivalentes de actividad de retinol. Conclusiones: Con esta aplicación informática se facilita la consulta de concentraciones de carotenoides en alimentos y el cálculo de su ingesta de forma ágil, específica y precisa, aspectos imprescindibles en los estudios de investigación sobre dieta y salud.

  14. Evaluation of factors affecting plate waste of inpatients in different healthcare settings.

    PubMed

    Valero Díaz, Antonio; Caracuel García, Angel

    2013-01-01

    Introducción/objetivos: La satisfacción de los pacientes con el servicio de comidas continúa siendo uno de los principales retos dirigidos a la modernización de los sistemas de distribución de alimentos. En el presente estudio se evaluó el impacto del tipo de hospital, horario, categoría de alimento y tipo de menú sobre el desecho de comida producido en diferentes recintos hospitalarios espAÑOles. Métodos: El desecho de alimentos se midió a través de una escala semi-cuantitativa con 5 niveles para evaluar la aceptabilidad del alimento («nada en plato» «¼ en plato» «mitad en plato» «¾ en plato» y «todo en plato»). El estudio se llevó a cabo en dos periodos de tres meses cada uno durante 2010 y 2011. Una persona entrenada se encargó del pesaje de platos, los cuales se clasificaron en 726 servicios pertenecientes a 11 menús diferentes. En total, se sirvieron 31.392 platos a 7.868 pacientes. Como prueba estadística se utilizó un test estadístico no paramétrico de Kruskal-Wallis (p < 0,05). Resultados: Los menús se consumieron de forma satisfactoria ya que más del 50% de los platos se clasificaron dentro de la categoría «nada en plato». Con respecto a las categorías de alimento, un 26,78% de los platos servidos se correspondieron con sopas y purés, mientras que los platos de pasta, arroz y alimentos listos para el consumo fueron distribuidos en un 4-5% de los servicios. Los postres fueron los platos más consumidos, mientras que los vegetales hervidos fueron menos aceptados. Otros factores como el tipo de hospital influyeron sobre el desecho de alimentos (p < 0,05) aunque el horario de servicio de comidas no (p > 0,05). Conclusión: La inspección visual del desecho de alimentos puede ser útil a la hora de optimizar el tipo y calidad de los menús servidos. El tipo de menú y la categoría de alimento podrían tener una gran influencia sobre la aceptabilidad de los platos por los pacientes.

  15. Nutritional adequacy in subjects with metabolic syndrome.

    PubMed

    Mesquita de Carvalho, Cláudia; Dias Mendonça, Dayana; Haas Piovesan, Carla; Edler Macagnan, Fabrício; Pandolfo Feoli, Ana Maria

    2014-11-16

    Introducción: La terapia nutricional en el tratamiento del síndrome metabólico es un factor clave. Es importante educar los pacientes sobre los beneficios de seguir el tratamiento cuando se quiere promover cambios nel estilo de vida. Objetivo: El objetivo fue evaluar la adecuación nutricional en individuos con síndrome metabólico de acuerdo con las recomendaciones dietéticas prescritas. Métodos: Un ensayo clínico con 72 sujetos con síndrome metabólico, llevados a cabo en el sur de Brasil. Asesoramiento nutricional se llevó a cabo, asociada o no con el ejercicio físico durante tres meses. Un retiro de alimentos de 24 horas, y un registro de alimentos de dos días fueron los métodos de referencia para el consumo de alimentos. La adecuación nutricional se determinó mediante la ingesta de energía y nutrientes, grupos de alimentos definidos por la Pirámide de Alimentos del Brasil. Results: Los voluntarios alcanzado un promedio del 80% del consumo de energía se recomienda. La ingestión de proteínas y lípidos fue mayor de lo esperado, y la ingesta de hidratos de carbono fue inferior a los niveles recomendados. Hubo una baja ingesta de cereales, verduras, productos lácteos y frijoles (p.

  16. Miltiorins A-D, diterpenes from Radix Salviae miltiorrhizae.

    PubMed

    Hirata, Ai; Kim, Sang-Yong; Kobayakawa, Natsuki; Tanaka, Naonobu; Kashiwada, Yoshiki

    2015-04-01

    Constituents of the anti-influenza A neuraminidase (NA) active extract from Radix Salviae miltiorrhizae were investigated, resulting in the isolation of four new diterpenes, miltiorins A-D (1-4), together with eight known diterpenes. The structures of 1-4 were assigned by spectroscopic analysis. Miltiorins A-C (1-3) were abietane diterpenes possessing a 2α-acetoxy group and a 12-hydroxy group in common, while miltiorin D (4) was a 11,12-seco-abietane diterpene with a γ-lactone ring. Miltiorin D (4) is the first example of a 11,12-seco-abietane diterpene from natural sources. Anti-NA activities of the isolated diterpenes were evaluated.

  17. Cadinane sesquiterpenes from Curcuma phaeocaulis with their inhibitory activities on nitric oxide production in RAW 264.7 cells.

    PubMed

    Ma, Jianghao; Wang, Ying; Liu, Yue; Gao, Suyu; Ding, Liqin; Zhao, Feng; Chen, Lixia; Qiu, Feng

    2015-06-01

    Four new cadinane-type sesquiterpenes named phacadinanes A-D (1-4) were isolated from the rhizomes of Curcuma phaeocaulis. Their structures were elucidated by 1D and 2D NMR, as well as accurate mass measurements. Compound 4 was the first example of a rare 4,5-seco-cadinane sesquiterpene isolated from the Zingiberaceae family. Furthermore, inhibitory effects of the isolated compounds on nitric oxide production in LPS-activated macrophages were evaluated. Compounds 1 and 2 showed strong inhibitory activities on NO production with IC50 values of 3.88±0.58 and 2.25±0.71 μM, respectively. A possible biogenetic pathway for 4,5-seco-cadinane sesquiterpene (4) was postulated.

  18. Diffusion near buildings as determined from atmospheric tracer experiments. Technical report

    SciTech Connect

    Sagendorf, J.F.; Ricks, N.R.; Start, G.E.; Dickson, C.R.

    1980-09-01

    Data from the innermost arcs and roof top samplers of the Rancho Seco and EOCR field studies were used to examine diffusion close to a building. The minimum length plume paths were determined from each release location to each sampler position at these two test sites. Measured concentrations, normalized by source strength (C/Q), were plotted versus plume path length and an envelope containing 95% of the measured values of C/Q was determined. The curves from the two sites were similar in shape and implied three zones of diffusion. Comparisons were also made with current NRC methods for predicting maximum expected concentrations close to a building. The NRC model overestimated concentrations in all but one case. The model was generally within an order of magnitude at EOCR, and within two orders of magnitude at Rancho Seco.

  19. Asteriscane-type sesquiterpenoids from the soft coral Sinularia capillosa.

    PubMed

    Chen, Dawei; Chen, Wei; Liu, Dong; van Ofwegen, Leen; Proksch, Peter; Lin, Wenhan

    2013-09-27

    Chemical examination of the soft coral Sinularia capillosa collected from the South China Sea resulted in the isolation of 14 new asteriscane-type sesquiterpenoids, namely, capillosananes A-N (1-14), four new seco-asteriscanes, capillosananes O-R (15-18), and (-)-sinularone A and sinularone A. Their structures were determined on the basis of extensive spectroscopic analyses, while the absolute configurations were determined by CD and ECD calculation, Mosher's method, and chemical conversion. This is the first report of asteriscane-type sesquiterpenoids from soft corals, and capillosananes Q (17) and R (18) represent new seco-asteriscane skeletons. Capillosanane A exhibited potent antifouling activity against Balanus amphitrite, with an IC₅₀ value of 9.70 μM, while capillosananes B and I and (-)-sinularone A inhibited inflammation-related TNF-α in vitro.

  20. [FOOD SOURCES OF SODIUM: ANALYSIS BASED ON A NATIONAL SURVEY IN COLOMBIA].

    PubMed

    Gaitán Charry, Diego Alejandro; Estrada, Alejandro; Argenor Lozano, Gustavo; Manjarres, Luz Mariela

    2015-11-01

    La ingesta elevada de sodio es un factor de riesgo independiente para el desarrollo de enfermedades cardiovasculares –ECV–. Por este motivo, a nivel global se promueve la implementación de la “reducción de la ingesta de sal/sodio como estrategia para la reducción de las ECV”. Para tal fin es importante identificar las fuentes de sodio en la dieta, lo cual hasta la fecha solo se ha realizado, fundamentalmente, en países desarrollados. Objetivos: identificar los alimentos que más sodio aportan a la dieta de los colombianos, basados en los datos de la Encuesta Nacional de la Situación Nutricional –ENSIN– de Colombia. Además, se pretende determinar el nivel de ingesta de sodio proveniente de alimentos en el país. Métodos: se analizaron datos de 39.413 individuos aparentemente sanos, no gestantes, entre los 2 y los 64 años de edad, obtenidos mediante R24h en la ENSIN. Se determinaron los grupos de alimentos que suponen una fuente de sodio, así como el sodio ingerido a partir de dichos alimentos. Resultados: se reportaron 1.274 alimentos y la agrupación de alimentos se realizó con un total de 95, los cuales aportaron un 72% del sodio total proveniente de los alimentos. Estos últimos se dividieron en 12 grupos. Dentro de estos, el de mayor aporte de sodio a la dieta fue el de productos de panadería (30,5%). El promedio de ingesta de sodio por persona proveniente del total de alimentos, sin adición de sal, fue 816,4 ± 474,1 mg/d. La mediana de la misma variable a nivel nacional fue de 721,0 mg/d (RQ = 476,0-1051,0). La ingesta fue mayor en hombres (784,0 mg/d; RQ = 511,0-1156,0) que en mujeres (665,0 mg/d; RQ = 448,0-953,0); p < 0,001. Conclusión: el presente trabajo identificó las principales fuentes de sodio en la dieta de los colombianos y sugiere la conveniencia de priorizar estrategias para la disminución del contenido de sodio en estos grupos, en especial el grupo de productos de panadería. Igualmente, es necesario tener en cuenta la

  1. Watershed Fire Regime Effects On Particulate Organic Carbon Composition in Oregon and California Coast Range Rivers

    NASA Astrophysics Data System (ADS)

    Hatten, J. A.; Goni, M. A.; Wheatcroft, R. A.; Borgeld, J. C.; Padgett, J. S.; Pasternack, G. B.; Gray, A. B.; Watson, E. B.; Warrick, J. A.

    2010-12-01

    Fire causes major changes to organic carbon, converting biological organic materials to pyrogenic-derived organic carbon (Py-OC), including black carbon. Wildfire also dramatically affects hydrological and erosion processes within watersheds, potentially increasing the erosion and discharge of Py-OC as particulate organic carbon (POC). We hypothesize that the proportion of the POC being discharged as Py-OC will be affected by the watershed’s fire regime, increasing with annual proportion of the watershed burned. During the 2008 and 2009 water years, suspended sediment samples were collected from the Alsea, Umpqua, Eel, Salinas, and Arroyo Seco Rivers draining the Coast Ranges of Oregon and California. Events and discharges of various magnitudes were captured in this sample set. This sample set also included suspended sediment collected from the Arroyo Seco River after a 2008 wildfire burned through a large portion of its watershed. Fine (<63 μm) and coarse (>63 μm) particulate material was analyzed for OC and N. We used cupric oxide oxidation to determine the contribution of Py-OC and unburned organic matter to the POC load of these rivers. The area weighted mean fire return interval decreases from the Douglas fir dominated forests in the Alsea River watershed in the north to the chaparral dominated Arroyo Seco River watershed in the south (Alsea > Umpqua > Eel > Salinas > Arroyo Seco). This translated into an increase in the proportion of each watershed burned from north to south. With the increase in annual proportion of watershed burned we found that the Py-OC content of coarse and fine POC increased from north to south. These results suggest that fire plays an important role in delivering POC to long-term carbon sinks in the coastal and ocean environment.

  2. 13. DETAIL VIEW OF BRIDGE, LOOKING SOUTH FROM ROADWAY. DETAIL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. DETAIL VIEW OF BRIDGE, LOOKING SOUTH FROM ROADWAY. DETAIL VIEW OF THE PIERS AND LIGHTING FIXTURES ON THE COLORADO STREET BRIDGE. THIS VIEW SHOWS A PORTION OF THE BRIDGE ALONG THE SOUTH SIDE OF THE ROADWAY. EACH FIXTURE ALSO ORIGINALLY HAD FOUR ADDITIONAL GLOBES, WHICH EXTENDED FROM THE COLUMN BELOW THE MAIN GLOBE. THE 'REFUGE' SEATING AREAS ARE ORIGINAL, WHILE THE RAILING IS A LATER ADDITION. - Colorado Street Bridge, Spanning Arroyo Seco at Colorado Boulevard, Pasadena, Los Angeles County, CA

  3. Triterpenoids and an alkamide from Ganoderma tsugae.

    PubMed

    Lin, Kai-Wei; Maitraie, Dravidum; Huang, A-Mei; Wang, Jih-Pyang; Lin, Chun-Nan

    2016-01-01

    Ganoderma tsugae is a medicinal mushroom. In a continual study on the bioactive constituents of this fungus, a new lanostanoid, 3β-acetoxy-16α-hydroxy-24ξ-methyl-5α-lanosta-8,25-dien-21-oic acid, named tsugaric acid F (1) and a novel palmitamide, N-(3'α,4'β-dihydroxy-2'β-(hydroxymethyl)-1'β-(cyclobutyl)palmitamide (2) were isolated and characterized from the fruit bodies of G. tsugae, and three novel seco-lanostanoids, 3,4-seco-8α,9α-epoxy-5α-lanosta-21-oic acid 3,4 lactone (5), 3,4-seco-5β-lanosta-7,9(11),4(29)-trien-3,21-dioic acid-3-methyl ester (6), 3,4-seco-5β-lanosta-7,9(11),4(29)-trien-3,21-dioic acid (7), and a known compound, 3-oxo-5α-lanosta-8-en-21-oic acid (4) were prepared from 3. The structures of new compounds, 1, 2, 5-7 were determined by spectroscopic methods. Compounds 1 and 4 showed inhibitory effects on xanthine oxidase (XO) with an IC50 values of 313.3 ± 80.0 and 43.9 ± 29.9 μM, respectively when 7 exhibited potent inhibitory effect on superoxide anion generation in rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB) with an IC50 values of 1.3 ± 0.2 μM. Compounds 4-7 showed weak cytotoxic activities against PC3 cells. These results indicated that 4 and 7 may be used as cancer chemopreventive agents. PMID:26598137

  4. Histidine 352 (His352) and Tryptophan 355 (Trp355) Are Essential for Flax UGT74S1 Glucosylation Activity toward Secoisolariciresinol

    PubMed Central

    Ghose, Kaushik; McCallum, Jason; Sweeney-Nixon, Marva; Fofana, Bourlaye

    2015-01-01

    Flax secoisolariciresinol diglucoside (SDG) lignan is a natural phytoestrogen for which a positive role in metabolic diseases is emerging. Until recently however, much less was known about SDG and its monoglucoside (SMG) biosynthesis. Lately, flax UGT74S1 was identified and characterized as an enzyme sequentially glucosylating secoisolariciresinol (SECO) into SMG and SDG when expressed in yeast. However, the amino acids critical for UGT74S1 glucosyltransferase activity were unknown. A 3D structural modeling and docking, site-directed mutagenesis of five amino acids in the plant secondary product glycosyltransferase (PSPG) motif, and enzyme assays were conducted. UGT74S1 appeared to be structurally similar to the Arabidopsis thaliana UGT72B1 model. The ligand docking predicted Ser357 and Trp355 as binding to the phosphate and hydroxyl groups of UDP-glucose, whereas Cys335, Gln337 and Trp355 were predicted to bind the 7-OH, 2-OCH3 and 17-OCH3 of SECO. Site-directed mutagenesis of Cys335, Gln337, His352, Trp355 and Ser357, and enzyme assays revealed an alteration of these binding sites and a significant reduction of UGT74S1 glucosyltransferase catalytic activity towards SECO and UDP-glucose in all mutants. A complete abolition of UGT74S1 activity was observed when Trp355 was substituted to Ala355 and Gly355 or when changing His352 to Asp352, and an altered metabolite profile was observed in Cys335Ala, Gln337Ala, and Ser357Ala mutants. This study provided for the first time evidence that Trp355 and His352 are critical for UGT74S1’s glucosylation activity toward SECO and suggested the possibility for SMG production in vitro. PMID:25714779

  5. Triterpenoids and an alkamide from Ganoderma tsugae.

    PubMed

    Lin, Kai-Wei; Maitraie, Dravidum; Huang, A-Mei; Wang, Jih-Pyang; Lin, Chun-Nan

    2016-01-01

    Ganoderma tsugae is a medicinal mushroom. In a continual study on the bioactive constituents of this fungus, a new lanostanoid, 3β-acetoxy-16α-hydroxy-24ξ-methyl-5α-lanosta-8,25-dien-21-oic acid, named tsugaric acid F (1) and a novel palmitamide, N-(3'α,4'β-dihydroxy-2'β-(hydroxymethyl)-1'β-(cyclobutyl)palmitamide (2) were isolated and characterized from the fruit bodies of G. tsugae, and three novel seco-lanostanoids, 3,4-seco-8α,9α-epoxy-5α-lanosta-21-oic acid 3,4 lactone (5), 3,4-seco-5β-lanosta-7,9(11),4(29)-trien-3,21-dioic acid-3-methyl ester (6), 3,4-seco-5β-lanosta-7,9(11),4(29)-trien-3,21-dioic acid (7), and a known compound, 3-oxo-5α-lanosta-8-en-21-oic acid (4) were prepared from 3. The structures of new compounds, 1, 2, 5-7 were determined by spectroscopic methods. Compounds 1 and 4 showed inhibitory effects on xanthine oxidase (XO) with an IC50 values of 313.3 ± 80.0 and 43.9 ± 29.9 μM, respectively when 7 exhibited potent inhibitory effect on superoxide anion generation in rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB) with an IC50 values of 1.3 ± 0.2 μM. Compounds 4-7 showed weak cytotoxic activities against PC3 cells. These results indicated that 4 and 7 may be used as cancer chemopreventive agents.

  6. Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats.

    PubMed

    Felmlee, M A; Woo, G; Simko, E; Krol, E S; Muir, A D; Alcorn, J

    2009-08-01

    The present study involved a comparative analysis of the effects of purified flaxseed lignans, secoisolariciresinol diglucoside (SDG) and its aglycone metabolite (SECO), in hyperlipidaemic rats. For hypercholesterolaemia, female Wistars (six rats per group) were fed a standard or 1 % cholesterol diet and orally administered 0, 3 or 6 mg SDG/kg or 0, 1.6 or 3.2 mg SECO/kg body weight once daily for 4 weeks. Hypertriacylglycerolaemia was induced in male Sprague-Dawley rats (ten rats per group) by supplementing tap water with 10 % fructose. These rats were orally administered 0, 3 or 6 mg SDG/kg body weight once daily for 2 weeks. Fasting blood samples (12 h) were collected predose and at the end of the dosing period for serum lipid analyses. Rats were killed and livers rapidly excised and sectioned for lipid, mRNA and histological analyses. Chronic administration of equimolar amounts of SDG and SECO caused similar dose-dependent reductions in rate of body-weight gain and in serum total and LDL-cholesterol levels and hepatic lipid accumulation. SDG and SECO failed to alter hepatic gene expression of commonly reported regulatory targets of lipid homeostasis. SDG had no effect on serum TAG, NEFA, phospholipids and rate of weight gain in 10 % fructose-supplemented rats. In conclusion, our data suggest that the lignan component of flaxseed contributes to the hypocholesterolaemic effects of flaxseed consumption observed in humans. Future studies plan to identify the biochemical mechanism(s) through which flaxseed lignans exert their beneficial effects and the lignan form(s) responsible.

  7. Histidine 352 (His352) and tryptophan 355 (Trp355) are essential for flax UGT74S1 glucosylation activity toward secoisolariciresinol.

    PubMed

    Ghose, Kaushik; McCallum, Jason; Sweeney-Nixon, Marva; Fofana, Bourlaye

    2015-01-01

    Flax secoisolariciresinol diglucoside (SDG) lignan is a natural phytoestrogen for which a positive role in metabolic diseases is emerging. Until recently however, much less was known about SDG and its monoglucoside (SMG) biosynthesis. Lately, flax UGT74S1 was identified and characterized as an enzyme sequentially glucosylating secoisolariciresinol (SECO) into SMG and SDG when expressed in yeast. However, the amino acids critical for UGT74S1 glucosyltransferase activity were unknown. A 3D structural modeling and docking, site-directed mutagenesis of five amino acids in the plant secondary product glycosyltransferase (PSPG) motif, and enzyme assays were conducted. UGT74S1 appeared to be structurally similar to the Arabidopsis thaliana UGT72B1 model. The ligand docking predicted Ser357 and Trp355 as binding to the phosphate and hydroxyl groups of UDP-glucose, whereas Cys335, Gln337 and Trp355 were predicted to bind the 7-OH, 2-OCH3 and 17-OCH3 of SECO. Site-directed mutagenesis of Cys335, Gln337, His352, Trp355 and Ser357, and enzyme assays revealed an alteration of these binding sites and a significant reduction of UGT74S1 glucosyltransferase catalytic activity towards SECO and UDP-glucose in all mutants. A complete abolition of UGT74S1 activity was observed when Trp355 was substituted to Ala355 and Gly355 or when changing His352 to Asp352, and an altered metabolite profile was observed in Cys335Ala, Gln337Ala, and Ser357Ala mutants. This study provided for the first time evidence that Trp355 and His352 are critical for UGT74S1's glucosylation activity toward SECO and suggested the possibility for SMG production in vitro.

  8. Microwave (MW) irradiated Ugi four-component reaction (Ugi-4CR): Expedited synthesis of steroid-amino acid conjugates--A novel class of hybrid compounds.

    PubMed

    Borah, Preetismita; Borah, Juri Moni; Chowdhury, Pritish

    2015-06-01

    Microwave (MW) assisted chemical reactions are currently gaining considerable importance in organic synthesis to contribute in green technology. Considering the importance of peptidomimetic steroid-amino acid conjugates - a novel class of hybrid compounds having diverse biological properties, we report here synthesis of these compounds of alanine and valine methyl esters with seco-steroids (A, B and D ring cleavage) in expedited way by MW promoted Ugi-four-component reaction (Ugi-4CR).

  9. Heterocyclic steroids: synthesis of steroidal selena, tellura, and thialactones of estrane series.

    PubMed

    Siddiqui, A U; Satyanarayana, Y; Ahmed, I; Siddiqui, A H

    1996-05-01

    A successful approach in the synthesis of 3 beta-acetoxy-17a-selena-D-homo-1,3,5(10)-estratrien-17 -one (5), 3 beta-acetoxy-17a tellura-D-homo-1,3,5(10)-estratrien-17-one (6), and 3 beta-acetoxy-17a-thia-D-homo-1,3,5(10)-estratrien-17-one (7) was achieved from 3 beta-acetoxy-1,3,5(10)-estratrien-17-one (1). The Baeyer-Villiger reaction of 3 beta-acetoxy-1,3,5(10)-estratrien-17-one (1) with perbenzoic acid afforded 3 beta-acetoxy-17a-oxa-D-homo-1,3,5(10)-estratrien-17-one (2), which on reaction with hydrobromic acid gave 3 beta-acetoxy-seco-13-bromo-1,3,5(10)-estratrien-16-oic acid (3). Treatment of bromo acid (3) with thionyl chloride gave 3 beta-acetoxy-seco-13-bromo-1,3,5(10)-estratrien-17 acid chloride (4), whose reaction with Se and Te in the presence of sodium borohydride gave the desired products 5 and 6. Reaction of 3 beta-acetoxy-seco-13-bromo-1,3,5(10)-estratrien-17 acid chloride (4) with sodium sulfide gave the thia lactone derivative (7).

  10. Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities.

    PubMed

    Tokunaga, Saimi; Woodin, Bruce R; Stegeman, John J

    2016-10-01

    Dioxins and dioxin-like compounds (DLCs) enter the body mainly through diet and cause various toxicological effects through activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. Some plant extracts and phytochemicals are reported to suppress this transformation. However, most of these reports have been from in vitro experiments and few reports have been from in vivo experiments. In addition, there has been no report of foodstuffs that effectively prevent AhR-associated morphological abnormalities such as deformities caused by dioxins and DLCs in vivo. In this study, we show that secoisolariciresinol (SECO), a natural lignan-type polyphenolic phytochemical found mainly in flaxseed, has a rescuing effect, actually suppressing morphological abnormalities (pericardial edema) in zebrafish embryos exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126), a dioxin-like PCB congener. Importantly, the rescuing effect of SECO was still evident when it was applied 16 h after the beginning of exposure to PCB126. This study suggests that SECO may be useful as a natural suppressive agent for morphological abnormalities caused by dioxins and DLCs. PMID:27427306

  11. Anti-inflammatory activity and chemical profile of Galphimia glauca.

    PubMed

    González-Cortazar, Manasés; Herrera-Ruiz, Maribel; Zamilpa, Alejandro; Jiménez-Ferrer, Enrique; Marquina, Silvia; Alvarez, Laura; Tortoriello, Jaime

    2014-01-01

    Galphimia glauca, commonly known as "flor de estrella", is a plant species used in Mexican traditional medicine for the treatment of different diseases that have an acute or chronic inflammatory process in common. Aerial parts of this plant contain nor-seco-triterpenoids with anxiolytic properties, which have been denominated galphimines. Other compounds identified in the plant are tetragalloyl-quinic acid, gallic acid, and quercetin, which are able to inhibit the bronchial obstruction induced by platelet-activating factor. The objective of this work was to evaluate the anti-inflammatory effect of crude extracts from G. glauca and, by means of bioguided chemical separation, to identify the compounds responsible for this pharmacological activity. n-Hexane, ethyl acetate, dichloromethane, and methanol extracts showed an important anti-inflammatory effect. Chemical separation of the active methanol extract allowed us to identify the nor-seco-triterpenes galphimine-A (1) and galphimine-E (3) as the anti-inflammatory principles. Analysis of structure-activity relationships evidenced that the presence of an oxygenated function in C6 is absolutely necessary to show activity. In this work, the isolation and structural elucidation of two new nor-seco-triterpenes denominated as galphimine-K (4) and galphimine-L (5), together with different alkanes, fatty acids, as well as three flavonoids (17-19), are described, to our knowledge for the first time, from Galphimia glauca.

  12. Preparation, characterization and structure determination of CpFe(CO)(EPh3)SeCO-het complexes

    NASA Astrophysics Data System (ADS)

    El-khateeb, Mohammad

    2016-11-01

    The mixed CO/ER3 iron complexes bearing heterocyclic selenocarboxylato group CpFe(CO)(ER3)SeCO-het [het = 2-C4H3S (1), 2-C4H3O (2), sbnd CH2-2-C4H3S (3), E = P, R = Ph (a), OC2H5 (b); E = As (c), Sb (d), R = Ph)] are synthesized by the reactions of CpFe(CO)2SeCO-het with ER3 under photolytic conditions. The new complexes have been characterized by spectroscopic analysis (UV-Vis, IR, 1H, 31P NMR) and elemental analysis. The structures of CpFe(CO)(PPh3)SeCO-2-C4H3S (1a), CpFe(CO)(AsPh3)SeCO-2-C4H3S (1c) and CpFe(CO)(SbPh3)SeCO-2-C4H3S (1d) have been determined by X-ray crystal structure analysis.

  13. Assay of Protein and Peptide Adducts of Cholesterol Ozonolysis Products by Hydrophobic and Click Enrichment Methods

    PubMed Central

    2015-01-01

    Cholesterol undergoes ozonolysis to afford a variety of oxysterol products, including cholesterol-5,6-epoxide (CholEp) and the isomeric aldehydes secosterol A (seco A) and secosterol B (seco B). These oxysterols display numerous important biological activities, including protein adduction; however, much remains to be learned about the identity of the reactive species and the range of proteins modified by these oxysterols. Here, we synthesized alkynyl derivatives of cholesterol-derived oxysterols and employed a straightforward detection method to establish secosterols A and B as the most protein-reactive of the oxysterols tested. Model adduction studies with an amino acid, peptides, and proteins provide evidence for the potential role of secosterol dehydration products in protein adduction. Hydrophobic separation methods—Folch extraction and solid phase extraction (SPE)—were successfully applied to enrich oxysterol-adducted peptide species, and LC-MS/MS analysis of a model peptide–seco adduct revealed a unique fragmentation pattern (neutral loss of 390 Da) for that species. Coupling a hydrophobic enrichment method with proteomic analysis utilizing characteristic fragmentation patterns facilitates the identification of secosterol-modified peptides and proteins in an adducted protein. More broadly, these improved enrichment methods may give insight into the role of oxysterols and ozone exposure in the pathogenesis of a variety of diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s disease, and asthma. PMID:25185119

  14. Calcio y la prevención del cáncer

    Cancer.gov

    Hoja informativa que resume los resultados de estudios sobre el calcio y la prevención del cáncer. Incluye información sobre las recomendaciones dietéticas para calcio y la cantidad de calcio en los alimentos y en complementos de calcio.

  15. Dietary potential renal Acid load in venezuelan children.

    PubMed

    López-Sayers, Mayerling; Bernal, Jennifer; López, Michelle

    2015-05-01

    Objetivo: Determinar y analizar la carga acida potencial renal de la dieta (Potential Renal Acid Load PRAL) y el patron de alimentacion de ninos entre 1 a 6 anos aparentemente sanos. Métodos: Se seleccionaron segun conveniencia a padres de 52 ninos asistentes a una consulta de ninos sanos. La calidad de la dieta y el patron de alimentacion se evaluo mediante un recordatorio de 24 horas y un cuestionario de frecuencia de alimentos. Se calculo la ingesta de macronutrientes y grupos de alimentos, como carnes, lacteos, frutas y verduras. La ingesta de nutrientes se comparo con las recomendaciones de energia y nutrientes. El PRAL se determino segun el metodo de Remer y Manz, para determinar la carga acida de la dieta. Se aplico estadistica descriptiva y correlaciones entre el PRAL, nutrientes y grupos de alimentos. Resultados: La ingesta de proteinas, de leche y de carnes fue elevada, mientras que la ingesta de rutas y hortalizas fue baja. El PRAL fue positivo en 92% de los ninos, se asocio con mayor ingesta de energia, proteinas, grasas, carne y lacteos. La ingesta de proteinas fue > 2,5 g/kg/ dia en 46,2% de los ninos. Los grupos de alimentos con mayor desequilibrio debido a exceso fueron la carne y los productos lacteos, mientras que por deficit fue el grupo de frutas y hortalizas. Conclusión: La dieta se caracteriza por una elevada carga de acido o PRAL, lo que aumenta el riesgo de acidosis sistemica y sus consecuencias metabolicas.

  16. 77 FR 56255 - Pilot Program on NAFTA Trucking Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . Public... commercial zones). On July 8, 2011, FMCSA announced in the Federal Register [76 FR 40420] its intent to... number 1871386, an interstate motor carrier) and MG Alimentos Inc. (US DOT number 1442274, an...

  17. [Nutritional content of food, and nonalcoholic beverages advertisements broadcasted in children's slot of Colombian national television].

    PubMed

    Mejía-Díaz, Diana Margarita; Carmona-Garcés, Isabel Cristina; Giraldo-López, Paula Andrea; González-Zapata, Laura

    2014-04-01

    Objetivo: Describir el contenido nutricional de alimentos y bebidas no alcohólicas publicitados en la franja infantil vs general, en dos canales gratuitos privados de televisión nacional colombiana. Métodos: Estudio descriptivo transversal. La grabación se realizó en julio de 2012, durante cuatro días seleccionados aleatoriamente de 6:00 am a 12:30 pm. El contenido nutricional se clasificó según los criterios de perfiles nutricionales de la Food Standards Agency para nutrientes trazadores de riesgo, la Organización Panamericana de la Salud para grasa trans, y la Resolución colombiana 333 de 2011 para clasificar los alimentos como fuente o no, de nutrientes protectores. Se utilizó estadística descriptiva, prueba de Kolmogorov- Smirnov para establecer la normalidad y prueba de Chi cuadrado para la comparación entre variables. Se consideró un p < 0,05. Resultados: En 52 horas de grabación se emitieron 1.560 pautas publicitarias, de las cuales el 23,3% (364 pautas), fue de publicidad de alimentos y bebidas y de estas, el 56,3% se publicitaron en la franja infantil. En cuanto al contenido nutricional, se destacó mayor porcentaje de alimentos y bebidas no alcohólicas clasificados como “altos” en azúcar, sodio y grasa saturada en la franja infantil (69,0%, 56,0%, 57,1%) respecto a la franja general. Por el contrario, el porcentaje de alimentos y bebidas no alcohólicas clasificados como “alto” en grasa total fue mayor en la franja general vs la franja infantil (70,4%, 29,6% respectivamente). Conclusiones: Una mayor exposición a la publicidad de alimentos y bebidas no alcohólicas se evidenció en la franja infantil, caracterizada por alto contenido de nutrientes trazadores de riesgo y bajo contenido de nutrientes protectores de los alimentos y bebidas no alcohólicas publicitados.

  18. Addition of dietary fiber sources to shakes reduces postprandial glycemia and alters food intake.

    PubMed

    Galvão Cândido, Flávia; Silva Ton, Winder Tadeu; Gonçalves Alfenas, Rita de Cássia

    2014-09-15

    Introducción: Obesidad y diabetes de tipo 2 pueden ser controlados por alimentos capaces de modular la ingesta de alimentos y la glucemia. Objetivos: Se investigó si la adición de alimentos fuentes de fibra o fasolamina a batidos puede controlar la ingesta de alimentos y reducir la glucemia posprandial. Métodos: Estudio aleatorizado, simple ciego, de diseño cruzado (ingesta de alimentos:n=22; glucemia:n=10). Cinco batidos con cantidades similares de macronutrientes (C - control batido, SA - salvado de avena batido, L - linaza batido, FB - extracto de frijol blanco batido y PI - harina de plátano no maduro batido) fueron consumidos en cinco días no consecutivos. Las participantes registraron la ingesta de alimentos en las 24 horas subsiguientes. La glucosa en sangre se midió a 0 (inmediatamente antes), 15, 30, 45, 60, 90 y 120 minutos después de la ingestión de cada batido y se calcularon las áreas incrementales bajo las curvas (AIBC). Resultados: En comparación a C, hubo un aumento significativo en la ingesta de fibra después de que el consumo de SA(+17,9g), SL(+19,1g), y PI(+12,6g), y en la grasa después del consumo de SA(+25,4g). Se encontró una reducción no significativa de la ingesta diaria de energía en L (1524kJ, P=0,10) en comparación con C. Hubo una reducción del 43% en el AIBC (P=0,03) en respuesta al consumo PI. Conclusiones: Harina de plátano no maduro reduce la respuesta glucémica posprandial de batidos casi a la mitad. El efecto de salvado de avena y linaza en la ingesta de alimentos requiere mayor investigación en estudios a largo plazo.

  19. EFFECTIVENESS OF AN EDUCATIONAL INTERVENTION TO REDUCE THE CONSUMPTION OF HIGH-CALORIE FOODS IN PUBLIC SCHOOL CHILDREN IN TERESINA, PIAUÍ (BRAZIL).

    PubMed

    Melo dos Santos, Marize; Passos Oliveira, Vanessa; Teixeira Lima, Sueli Maria; Clímaco Cruz, Kyria Jayanne; Soares de Oliveira, Ana Raquel; Soares Severo, Juliana

    2015-08-01

    Introdución: existe una alta prevalencia de sobrepeso y hábitos alimentarios pobres entre los adolescentes, y estos factores contribuyen al desarrollo de enfermedades crónicas. Objetivo: el objetivo de este estudio fue evaluar la efectividad de una intervención educativa diseñada para reducir el consumo de alimentos con alto contenido calórico en los niños de las escuelas públicas en Teresina, Piauí (Brasil). Material y métodos: estudio cuasi-experimental, aleatorizados y de intervención cuantitativo realizado con adolescentes (n = 126), con edades comprendidas entre 10 y 14 años, de ambos sexos. La intervención educativa se desarrolló durante nueve semanas, con reuniones semanales. Se realizó una encuesta previa y posterior a la intervención. Las asociaciones entre las variables fueron examinadas usando una prueba de chi-cuadrado (x2). Resultados: se observó una reducción significativa en el consumo de refrescos y jugos procesados posterior a la intervención educativa (p = 0,007). Tiene una mayor reducción en el consumo semanal de alimentos embutidos (p = 0,072). El consumo semanal de los adolescentes de alimentos fritos y patatas fritas también se redujo significativamente después de la intervención educativa (p < 0,001). Conclusiones: el programa educativo de alimentación y nutrición fue eficaz en la reducción de la ingesta de alimentos altos en calorías y bebidas de los adolescentes, lo cual contribuyó a una mejora en la calidad de los alimentos consumidos por los niños de las escuelas evaluadas.

  20. Tv food advertising geared to children in Latin-American countries and Hispanics in the USA: a review.

    PubMed

    Bacardí-Gascón, Montserrat; Jiménez-Cruz, Arturo

    2015-05-01

    Introducción: El propósito de esta revisión fue analizar los estudios sobre anuncios de alimentos en la TV en Latinoamérica y en los EEUU dirigidos a Hispanos. Métodos: Se realizó una búsqueda electrónica de trabajos publicados de 1986 a 2015, en las bases de datos de MEDLINE/PubMed, EMBASE, SCIELO, y CINAHL, en internet de acceso abierto, sobre anuncios de alimentos en la televisión dirigidos a niños en países latinoamericanos y a Hispanos que viven en los Estados Unidos. Resultados: La búsqueda dio como resultado veinticuatro estudios, seis realizados en Chile, cinco en México, cuatro en Brasil, tres en Hispanos de EEUU, y uno en cada uno de los siguientes países: Argentina, Perú, Colombia, Honduras y Venezuela. Una gran proporción de anuncios sobre alimentos en la TV están dirigidos a los niños y a sus familias. Esta exposición ha sido asociada a la preferencia y solicitud de compra de estos alimentos por los niños y con un aumento del IMC, sobrepeso y obesidad en niños y adultos. Conclusión: Se observa una alarmante alta exposición de anuncios de alimentos en la TV dirigida a niños, lo que demanda políticas regulatorias, supervisión, y rendimiento de cuentas eficaces.

  1. Modifiable environmental obesity risk factors among elementary school children in a Mexico-us border city.

    PubMed

    López-Barrón, Rita Gabriela; Jiménez-Cruz, Arturo; Bacardí-Gascón, Montserrat

    2015-05-01

    Antecedentes: El aumento de la prevalencia de sobrepeso (SP) y la obesidad (OB) en niños mexicanos, hace necesario la valoración de los factores de riesgo ambientales. Objetivo: Valorar si existe asociación entre la disponibilidad de alimentos en el entorno de los niños y el consume de alimentos con el puntaje Z de IMC y la circunferencia de cintura (CC). Métodos: Participaron en el estudio 684, 264 padres, 22 maestros, el personal de cafetería de las escuelas, y vendedores ambulantes. Se valoró el peso, la estatura la CC, de niños de quinto año de educación básica. Se aplicaron a los padres, niños y maestros un cuestionario de frecuencia de consumo de alimentos, uno de actividad física y uno de hábitos alimentarios. Un inventario de alimentos se aplicó a los padres, al personal de la cafetería de la escuela, a los vendedores y a las tiendas cercanas a las escuelas. Resultados: La media de edad de los niños fue 10.5 años. 28% de los niños tenían SP, 26% OB, y 25% obesidad abdominal (OA). Se observó una correlación positiva entre el consumo de alimentos densamente energéticos (ADE), frutas, y verduras con la disponibilidad en casa y con el consumo semanal. También se observó una correlación entre el consumo de refrescos y otras ADE. El factor que más contribuía al consumo de alimentos fue la disponibilidad en casa y en la escuela (R2 = 0.11, p = 0.0001). Se observó una asociación positiva entre el tiempo que los niños ven televisión con el de sus padres. Por cada hora de aumento (de 0 a 7) de ver televisión al día, los niños tenían más posibilidades de tener SP o OB (OR=1.22 95% CI 1.02-1.45, p=0.026). Conclusión: La disponibilidad de ADE, de frutas y verduras en o fuera de casa o de la escuela, además de las horas de ver televisión estuvieron positivamente asociadas con la obesidad.

  2. [DESIGN AND VALIDATION OF AN IMAGE FOR DISSEMINATION AND IMPLEMENTATION OF CHILEAN DIETARY GUIDELINES].

    PubMed

    Olivares Cortés, Sonia; Zacarías Hasbún, Isabel; González González, Carmen Gloria; Fonseca Morán, Lilian; Mediano Stoltze, Fernanda; Pinheiro Fernandes, Anna Christina; Rodríguez Osiac, Lorena

    2015-08-01

    Introducción: las Guías Alimentarias Basadas en Alimentos (GABA) generalmente van acompañadas de una imagen para su difusión e implementación. Objetivo: diseñar y validar una imagen que represente la variedad y proporcionalidad de las nuevas guías alimentarias para la población chilena, incluyendo los alimentos altos en nutrientes críticos que es necesario evitar y la actividad física. Método: un panel de expertos analizó siete propuestas gráficas y seleccionó tres que fueron validadas con 12 grupos focales de personas de 10-14 y 20-40 años, distinto sexo, nivel socioeconómico y sector urbano/rural. Se analizó la percepción de la variedad y proporcionalidad de los grupos de alimentos a comer diariamente y la motivación a la acción en alimentación y actividad física. Se trabajó con METAPLÁN, método ya utilizado en la validación de las GABA. Resultados y discusión: la imagen definitiva es un círculo que presenta la variedad y proporcionalidad de los grupos de alimentos a consumir durante el día (en fotografías), incluye la actividad física en una franja que rodea la mitad del círculo y un rectángulo inferior con ejemplos de alimentos altos en nutrientes críticos en blanco y negro. La imagen elegida fue modificada con las aportaciones de los participantes y validada con tres nuevos grupos focales, mejorando su comprensión y aceptación. Conclusión: la mayoría de los participantes comprendió que la imagen representaba la relación entre la alimentación saludable y la actividad física diaria, identificando los grupos de alimentos de los que se sugiere comer más y de los que se necesita reducir o evitar su consumo.

  3. Enhanced recharge and karst, Edwards aquifer, south central Texas

    SciTech Connect

    Hammond, W.W. Jr. . Center for Water Research)

    1993-02-01

    Enhanced recharge is a water management strategy which can add significant quantities of ground water to the available water resources of the San Antonio region by utilizing the immense storage capacity of the unconfined zone of the Edwards aquifer. The Edwards aquifer presently is the sole source of water for a population of over 1,200,000, meeting public supply, industrial, and irrigation demands over a wide area of south central Texas. Valdina Farms Sinkhole is located adjacent to Seco Creek in Medina County and is in the recharge zone of the aquifer. Initial studies indicated that the sinkholes was capable of taking flood flows from Seco Creek and functioning as a recharge structure. Stream channels in the cavern system associated with Valdina Farms Sinkhole were incised into cave deposits and flood debris was present in the caverns at some distance from the sinkhole. Chemical analyses of samples of water from the cave and from nearby wells showed nitrate concentrations that decreased with distance from the cavern. Gradient of the potentiometric surface in the vicinity of the cave was very low, indicating high values of hydraulic conductivity for the aquifer. Based on evidence from these field studies a dam was constructed in 1982 on Seco Creek and a flood diversion channel was excavated to the sinkhole. Reservoir capacity is 2 acre-feet and design recharge rate is 3.8-6.7 m[sup 3]/sec. Annual recharge at the sinkhole has varied from 0 during periods of low runoff to 12,915 acre-feet.

  4. Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells.

    PubMed

    During, Alexandrine; Debouche, Céline; Raas, Thomas; Larondelle, Yvan

    2012-10-01

    Dietary lignans show some promising health benefits, but little is known about their fate and activities in the small intestine. The purpose of this study was thus to investigate whether plant lignans are taken up by intestinal cells and modulate the intestinal inflammatory response using the Caco-2 cell model. Six lignan standards [secoisolariciresinol diglucoside (SDG), secoisolariciresinol (SECO), pinoresinol (PINO), lariciresinol, matairesinol (MAT), and hydroxymatairesinol] and their colonic metabolites [enterolactone (ENL) and enterodiol] were studied. First, differentiated cells were exposed to SDG, SECO, PINO, or ENL at increasing concentrations for 4 h, and their cellular contents (before and after deconjugation) were determined by HPLC. Second, in IL-1β-stimulated confluent and/or differentiated cells, lignan effects were tested on different soluble proinflammatory mediators quantified by enzyme immunoassays and on the NF-κB activation pathway by using cells transiently transfected. SECO, PINO, and ENL, but not SDG, were taken up and partly conjugated by cells, which is a saturable conjugation process. PINO was the most efficiently conjugated (75% of total in cells). In inflamed cells, PINO significantly reduced IL-6 by 65% and 30% in confluent and differentiated cells, respectively, and cyclooxygenase (COX)-2-derived prostaglandin E(2) by 62% in confluent cells. In contrast, MAT increased significantly COX-2-derived prostaglandin E(2) in confluent cells. Moreover, PINO dose-dependently decreased IL-6 and macrophage chemoattractant protein-1 secretions and NF-κB activity. Our findings suggest that plant lignans can be absorbed and metabolized in the small intestine and, among the plant lignans tested, PINO exhibited the strongest antiinflammatory properties by acting on the NF-κB signaling pathway, possibly in relation to its furofuran structure and/or its intestinal metabolism.

  5. Benthic macroinvertebrate richness along Sausal Creek, Oakland, California

    NASA Astrophysics Data System (ADS)

    Lara, D.; Ahumada, E.; Leon, Y.; Bracho, H.; Telles, C.

    2012-12-01

    Sausal Creek, 5.0 km long, is one of the principal watercourses in Oakland, California. The headwaters of Sausal Creek arise in the Oakland Hills and the creek flows southwestward through the city, discharging into the tidal canal that separates the island of Alameda from Oakland; the creek ultimately flows into San Francisco Bay. Due to the presence of rainbow trout, the stream health of Sausal Creek is a local conservation priority. In the present study, a survey of benthic macroinvertebrates in the creek was conducted and possible correlations between environmental variables and taxonomic richness were analyzed. Three stations along the creek were sampled using a 30.5cm 500 micron aquatic d-net, and temperature, pH and dissolved oxygen levels were measured in creek samples obtained at each station. Temperature, pH and dissolved oxygen levels remained constant along the creek. Taxonomic richness was highest at the upstream site of Palo Seco, located in an eastern section of the creek, and furthest downstream at Dimond Park, in the western portion of the creek. The Monterrey site, just west of Palo Seco was found to be significantly low in benthic macroinvertebrates. The Palo Seco and Monterrey sites are separated by Highway 13 and storm drain inputs may bring contaminants into the creek at this site. At the Monterrey site Sausal Creek follows the Hayward Fault, gas emissions or change in substrate may also affect the local population of benthic invertebrates. Further research will be conducted to determine what factors are contributing to this local anomaly.

  6. Monoterpenoid glucoindole alkaloids and iridoids from Pterocephalus pinardii.

    PubMed

    Gülcemal, Derya; Masullo, Milena; Alankuş-Calişkan, Ozgen; Karayildirim, Tamer; Senol, Serdar G; Piacente, Sonia; Bedir, Erdal

    2010-03-01

    A new secondary metabolite, pterocephaline, along with the known cantleyoside, 7alpha-morroniside, 3beta,5alpha-tetrahydrodesoxycordifoline lactam, 5S-5-carboxyvincoside, sweroside, and loganin have been isolated from the aerial parts of P. pinardii (Dipsacaceae). Moreover, cantleyoside-methyl-hemiacetal and cantleyoside-dimethyl-acetal were obtained as seco-iridoid artifacts. The structures were elucidated by extensive spectroscopic methods including 1D-((1)H, (13)C and TOCSY) and 2D-NMR (DQF-COSY, HSQC and HMBC). Monoterpenoid glucoindole alkaloids were encountered for the first time in Dipsacaceae family.

  7. Direct synthesis of macrodiolides via hafnium(IV) catalysis.

    PubMed

    de Léséleuc, Mylène; Collins, Shawn K

    2015-07-01

    Efficient direct synthesis of macrodiolides via catalysis using Hf(OTf)4 is possible in high yields, forming water as the sole by-product. The first protocol for the direct synthesis of macrodiolides from equimolar mixtures of diols and dicarboxylic acids was developed (58-96%). In addition, modification of the reaction concentration allows for the synthesis of head-to-tail macrodiolides from the corresponding seco acids. The catalytic preparation of the macrodiolides using a commercially available catalyst without the need for slow addition or azeotropic condition provides an operationally simple alternative to protocols which employ toxic tin catalysts or stoichiometric activation strategies.

  8. Brevisulcatic acids, marine ladder-frame polyethers from the red tide dinoflagellate Karenia brevisulcata in New Zealand.

    PubMed

    Suzuki, Rina; Irie, Raku; Harntaweesup, Yanit; Tachibana, Kazuo; Holland, Patrick T; Harwood, D Tim; Shi, Feng; Beuzenberg, Veronica; Itoh, Yoshiyuki; Pascal, Steven; Edwards, Patrick J B; Satake, Masayuki

    2014-11-21

    The isolation and structural determination of new marine ladder-frame polyethers, brevisulcatic acids-1 (1) and -4 (2) are reported. Brevisulcatic acids were isolated from the dinoflagellate Karenia brevisulcata, which was identified as the causative species of a major red tide event in New Zealand in 1998. The ether ring composition and a β-hydroxy, γ-methylene valeric acid side chain of 1 and 2 are common, but 2 has a γ-lactone as the 5-membered A-ring while 1 is the seco acid analogue. Compound 2 has structural and bioactivity similarities to brevetoxin A.

  9. Recent results in the search for new molecules with ambergris odor.

    PubMed

    Panten, Johannes; Surburg, Horst; Hölscher, Bernd

    2014-10-01

    The synthesis of new odorant molecules is still a challenging task for the fragrance chemist, because now as ever it is difficult to predict the odor properties of small organic molecules. Therefore, certain tools, such as, e.g., lead-structure optimization of existing odorants, are helpful techniques. In this article, we describe the synthesis and the odor properties of a new molecule derived by the so-called 'seco' lead-structure optimization of the ambergris compound Ambroxide(®) . Based on these results, more representatives with similar structures have been synthesized and evaluated for their olfactory properties.

  10. Antitussive stemoninine alkaloids from the roots of Stemona tuberosa.

    PubMed

    Lin, Li-Gen; Li, Kan Man; Tang, Chun-Ping; Ke, Chang-Qiang; Rudd, John A; Lin, Ge; Ye, Yang

    2008-06-01

    Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a- O-methylstemoenonine (2), oxystemoenonine (3), 1,9a- seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D NMR spectra and other spectroscopic studies. Alkaloids 1, 2, and 6, as well as the representative stemoninine-type alkaloid, stemoninine (7), were screened for antitussive activity in the citric acid-induced guinea pig cough model. Compounds 6 and 7 exhibited strong antitussive activity after oral and intraperitoneal administrations.

  11. Diterpenoids from the twigs and leaves of Croton caudatus var. tomentosus.

    PubMed

    Song, Jin-Tong; Han, Yang; Wang, Xiao-Ling; Shen, Tao; Lou, Hong-Xiang; Wang, Xiao-Ning

    2015-12-01

    One new 9,10-seco-abietane derivative, crotontomentosin A (1), four new abietane-type diterpenoids, crotontomentosins B-E (2-5), one new ent-halimane-type diterpenoid, crotontomentosin F (6), along with five known diterpenoids (7-11) and one known sesquiterpenoid (12) were obtained from the twigs and leaves of Croton caudatus Geisel. var. tomentosus Hook. The structures of the compounds were established on the basis of extensive spectroscopic data. Compounds 1-4 and 11 exhibited moderate to weak inhibitory activity against the proliferation of the Hela, Hep G2, MDA-MB-231, or A549 cell lines selectively.

  12. Withanolides from three species of the genus Deprea (Solanaceae). Chemotaxonomical considerations.

    PubMed

    Casero, Carina N; Oberti, Juan C; Orozco, Clara I; Cárdenas, Alejandro; Brito, Iván; Barboza, Gloria E; Nicotra, Viviana E

    2015-02-01

    Nine withanolides were isolated from the aerial parts of Deprea bitteriana, Depreacuyacensis, and Depreazamorae. D.bitteriana yielded two withaphysalins, D. cuyacensis gave two 13,14-seco withaphysalins, while D. zamorae yielded five physangulidines. The compounds were fully characterized by a combination of spectroscopic methods (1D and 2D NMR and MS). All compounds isolated from D.bitteriana and D. cuyacensis were obtained as epimeric mixtures at C-18. The structure of physangulidine D was confirmed by X-ray diffraction analysis. The skeletons found in this research support the chemotaxonomical position of the genus Deprea in the tribe Physalideae.

  13. Direct synthesis of macrodiolides via hafnium(IV) catalysis.

    PubMed

    de Léséleuc, Mylène; Collins, Shawn K

    2015-07-01

    Efficient direct synthesis of macrodiolides via catalysis using Hf(OTf)4 is possible in high yields, forming water as the sole by-product. The first protocol for the direct synthesis of macrodiolides from equimolar mixtures of diols and dicarboxylic acids was developed (58-96%). In addition, modification of the reaction concentration allows for the synthesis of head-to-tail macrodiolides from the corresponding seco acids. The catalytic preparation of the macrodiolides using a commercially available catalyst without the need for slow addition or azeotropic condition provides an operationally simple alternative to protocols which employ toxic tin catalysts or stoichiometric activation strategies. PMID:26028490

  14. Nuclear Regulatory Commission issuances, June 1996. Volume 43, Number 6

    SciTech Connect

    1996-06-01

    This report covers the issuances received during the specified period form the Commission, the Atomic Safety and licensing Boards, the administrative Law Judges, the Director`s decisions and the Decisions on Petitions for Rulemaking. Included are a memorandum and order on the decommissioning plan for Yankee Nuclear Power Station, a memorandum and order suspending byproduct material license for Eastern Testing and Inspection, Inc., an initial decision of the source materials license for Sequoyah Fuels Corporation, Director`s decisions for Palo Verde Nuclear Generating Station, Indian Point, Peach Bottom Atomic Power Station, Trojan Nuclear Plant, Rancho Seco Nuclear Generating Station, San Onofre Nuclear Generating Station, and Yankee Nuclear Power Station.

  15. Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp. TZP29.

    PubMed

    Zhu, Meilin; Gao, Huquan; Wu, Chongming; Zhu, Tianjiao; Che, Qian; Gu, Qianqun; Guo, Peng; Li, Dehai

    2015-09-01

    Two new C12 polyketides, cladospolides E and F (1 and 2), together with four known derivatives seco-patulolides A and C (3 and 4), 11-hydroxy-γ-dodecalactone (5) and iso-cladospolide B (6), were isolated from a soft coral-derived fungus Cladosporium sp. TZP-29. Their structures, including the absolute configurations, were elucidated by spectroscopic analysis, modified Mosher's method, and the analysis of their biogenesis. All compounds were non-cytotoxic while compounds 1 and 3-5 showed potent lipid-lowering activity in HepG2 hepatocytes.

  16. Variability of glycemic and insulin response to a standard meal, within and between healthy subjects.

    PubMed

    Hirsch, Sandra; Barrera, Gladys; Leiva, Laura; de la Maza, María Pía; Bunout, Daniel

    2013-01-01

    Objetivo: Evaluar la variabilidad inter e intra individual de la respuesta glicémica frente a la ingestión de un alimento estándar en sujetos sanos. Material y métodos: Se midió en 6 oportunidades la respuesta glicémica e insulínica de un alimento estándar (pan batido blanco) en 10 voluntarios sanos. A cada sujeto se le midió la glicemia e insulina en ayuno a los 15, 45, 60, 90, 120, 150 y 180 minutos, después de ingerir el alimento estándar. Posteriormente se calculó el área bajo la curva (ABC) de glicemia e insulina en cada sujeto. Se calculó el coeficiente de variación intra e inter individual del ABC de glucosa e insulina. Resultados: La variación intra-individual total del ABC de glucosa fue de 51,8% (rango: 24,9%-91,4%). La variación inter-individual del ABC de glucosa total fue 75,2%. La variación intra-individual del ABC de insulina fue de 51,9% (rango: 7,7%-103%). La variación inter-individual del ABC de insulina total fue de 86%. Conclusión: La respuesta glicémica e insulínica a un alimento estándar tiene poca reproducibilidad, tanto intra e inter individual. En consecuencia, su utilidad clínica para la prescripción dietaria individual, está limitada.

  17. Estimation of antioxidants dietary intake in wet age-related macular degeneration patients.

    PubMed

    Bibiloni, Maria del Mar; Zapata, Maria Elisa; Aragón, Juan A; Pons, Antoni; Olea, José Luis; Tur, Josep A

    2014-04-01

    Objetivos: El objetivo de este estudio fue estimar la ingesta de nutrientes antioxidantes en pacientes con degeneración macular asociada a la edad (AMD) variedad húmeda, un trastorno degenerativo y progresivo de la mácula, la parte central de la retina, asociada con la pérdida de la visión central. Métodos: En una muestra de pacientes diagnosticados de AMD (n = 52, 78,9 ± 6,6 años, 40,4% mujeres y 59,6% hombres) se registraron medidas antropométricas, dos recordatorios de 24 h, un cuestionario semicuantitativo de frecuencia de consumo de alimentos y cuestiones sociodemográficas y de estilo de vida. Resultados: La mayoría de los pacientes con AMD húmeda mostraron una ingesta inadecuada de nutrientes antioxidantes (< 2/3 de las Ingestas Dietéticas Recomendadas, RDI) y más de 60% de los pacientes mostraron un déficit grave (< 1/3 RDI) de luteína y zeaxantina. Los alimentos ricos en antioxidantes más consumidos sólo aportaron bajas contribuciones a la ingesta de antioxidantes. Aunque la adiposidad es un factor de riesgo para la progresión de la AMD, el consumo de grasas y ácidos grasos saturados (SFA) de los pacientes fueron superiores a las recomendaciones; la prevalencia de sobrepeso fue del 61,9% hombres y 58.1% en las mujeres; y el 83% de los pacientes (90,5% hombres y 77,4% mujeres) mostró una masa grasa superior a los límites. Conclusiones: El patrón alimentario de los pacientes con AMD debería mejorarse aumentando el consumo de alimentos ricos en antioxidantes y disminuyendo los alimentos ricos en SFA.

  18. [Dietary training for school food service providers in support of the Acuerdo Nacional para la Salud Alimentaria].

    PubMed

    Muñoz-Dávila, Carolina; Rangel-Peniche, Diana Beatriz

    2015-01-01

    Introducción: en apoyo a la problemática de sobrepeso y obesidad en México, en el 2010 se publicó el Acuerdo Nacional para la Salud Alimentaria. A nivel escolar, los comodatarios se consideraron fundamentales para cumplir con ciertos compromisos. El objetivo de esta intervención fue capacitar a comodatarios de los Establecimientos de Consumo Escolar (ECE) en cuanto a los criterios establecidos en los “Lineamientos Generales para el Expendio y Distribución de Alimentos en Planteles de Educación Básica.” Métodos: participaron 13 ECE en San Luis Potosí. Con base en un diagnóstico inicial, se diseñó un curso-taller de 5 sesiones. Se evaluaron conocimientos en materia alimentaria al inicio y al final de las sesiones. Se obtuvo el porcentaje de apego en cuanto a higiene general, preparación y distribución de alimentos, al inicio, al mes y a los dos meses postintervención. Resultados: los comodatarios presentaron pocos conocimientos en los objetivos que persigue el “Acuerdo” en grupos y combinación de alimentos así como en lectura de etiquetas; con cambios significativos en los dos últimos tras la intervención. El porcentaje inicial de cumplimiento en higiene general fue del 60 %, con un incremento de casi 20 % postcapacitación. La preparación y distribución de alimentos no presentaron cambios significativos. Conclusiones: los comodatarios adquirieron conocimientos sobre los lineamientos que debe cubrir un ECE, sin ponerlos en práctica, dado el impacto que ello implica en su economía.

  19. [Vitamin and minerals consumed food group by Chilean university students].

    PubMed

    Durán Aguero, Samuel; Reyes García, Susanne; Gaete, María Cristina

    2013-01-01

    Introducción: La etapa universitaria es un proceso en el cual las personas pasan por periodos prolongados de inactividad física y horarios irregulares de comidas, lo que conlleva al incremento en el consumo de alimentos procesados y de comida rápida. Objetivo: Fue determinar el aporte vitaminas y minerales por grupo de alimentos en la alimentación de estudiantes universitarios. Métodos: Se trabajó con una muestra de 654 estudiantes universitarios chilenos (18-24 años, 54% mujeres), a quienes se les aplicó un cuestionario de frecuencia semanal de consumo de alimentos, la información recolectada se clasificó en 12 grupos representativos de cada conjunto de alimentos y se determinó la ingesta de vitaminas y minerales. Resultados: Los principales resultados fueron: (a) las mujeres presentaron menor ingesta de la mayoría de micronutrientes que los hombres; (b) el ácido pantotenico, la vitamina B12 y E, el calcio, magnesio y el hierro son los nutrientes que presentaron ingestas promedio inferiores a las recomendaciones diarias; (c) el consumo de pan es fundamental para el aporte de vitaminas del complejo B, hierro, cobre y selenio. Conclusión: En la dieta habitual de los estudiantes universitarios chilenos, el pan constituye un elemento fundamental para el aporte dietario de vitaminas del complejo B, hierro, cobre y selenio; así como los lácteos para el calcio; las carnes y pescado para la vitamina B12 y el zinc; las verduras para la vitamina A y las frutas para la vitamina C.

  20. [Validity of an instrument for assessing food consumption, food habits and cooking skills in 8-11 years old students].

    PubMed

    Lera, Lydia; Fretes, Gabriela; González, Carmen Gloria; Salinas, Judith; Vio del Rio, Fernando

    2015-05-01

    Introducción: Para medir cambios en prácticas alimentarias, se requieren instrumentos que midan conocimiento, consumo, habilidades culinarias, hábitos y gastos en alimentos en las escuelas. Objetivo: Validar un instrumento que permita medir cambios en conocimiento, consumo, habilidades culinarias, hábitos y gastos en niños de 8 a 11 años, de tercero a quinto básico, en escuelas públicas de Chile. Métodos: Se realizó un estudio de validación de un cuestionario de 42 preguntas de conocimiento, consumo, habilidades culinarias, hábitos y gastos en la escuela. Se realizó en dos etapas: la primera en 45 niños para evaluar la estabilidad temporal, concordancia y consistencia interna. La segunda fue aplicar el instrumento modificado con los resultados de la primera etapa en 90 niños para medir consistencia interna. Resultados: El cuestionario aplicado en los 45 niños mostró estabilidad temporal, concordancia y consistencia interna aceptables para habilidades culinarias, hábitos y gastos en la escuela. La consistencia fue buena para frecuencia de consumo, pero mala en conocimiento. En la validación final con 90 niños, se confirmó la buena consistencia para frecuencia de consumo y mala para conocimiento. Se observó que aquellos niños con habilidades culinarias, consumen más alimentos saludables y los que gastan más dinero en la escuela, consumen menos alimentos saludables. Conclusiones: Al instrumento se le quitaron las preguntas de conocimiento, quedando con 28 preguntas de consumo, habilidades culinarias, hábitos y gasto en alimentos en las escuelas. Este instrumento es útil para medir cambios en intervenciones educativas en alimentación y nutrición en niños de 8 a 11 años.

  1. [FOOD PATTERNS ASSOCIATED WITH A HEALTY BODY WEIGHT IN CHILEAN STUDENTS OF NUTRITION AND DIETETICS].

    PubMed

    Durán Agüero, Samuel; Fernández Godoy, Eloina; Fuentes Fuentes, Jessica; Hidalgo Fernández, Andrea; Quintana Muñoz, Carol; Yunge Hidalgo, Wilma; Fehrman Rosas, Pamela; Delgado Sánchez, Claudia

    2015-10-01

    Objetivo: determinar los patrones de alimentación y asociar el consumo de diversos alimentos con el estado nutricional de estudiantes universitarios chilenos de Nutrición y Dietética. Material y métodos: estudio transversal. Se evaluaron 634 estudiantes de Nutrición y Dietética de la Universidad San Sebastián de las ciudades de Santiago, Concepción, Valdivia y Puerto Montt. A cada estudiante se le aplicó una encuesta alimentaria y se le realizó una evaluación antropométrica. Resultados: el 68% de los estudiantes consume desayuno diariamente, 36,1% y 37,1% consume las porciones recomendadas de frutas y verduras, el 64,9% consume bebidas azucaradas frecuentemente. Se observa una asociación entre un buen peso corporal y el consumo de verduras (≥ 2 porciones/día) OR = 0,662 (0,440-0,996), alimentos integrales OR = 0,474 (0,224-1,002) y un bajo consumo de frituras y snack dulces OR = 0,643 (0,406- 1,019) y OR = 0,545 (0,360-0,825), respectivamente. Conclusiones: los estudiantes presentan una ingesta insuficiente de alimentos saludables y un elevado consumo de alimentos poco saludables, además se observa que la ingesta de verduras y cereales integrales, así como un bajo consumo de frituras y bocadillos dulces se asocian a un estado nutricional normal en los estudiantes evaluados.

  2. TV food advertisements' effect on food consumption and adiposity among women and children in Mexico.

    PubMed

    Bacardí-Gascón, Montserrat; Díaz-Ramírez, Glenda; Cruz López, Brenda; López Zuñiga, Erika; Jiménez-Cruz, Arturo

    2013-11-01

    Antecedentes: El objetivo de este estudio fue valorar la asociación entre los anuncios de alimentos en TV, los alimentos consumidos por las madres y los niños, y el peso corporal de madres y niños entre población con diferentes niveles socioeconómicos. Métodos: De junio a octubre de 2011 en Tijuana y Tuxtla Gutiérrez, se grabaron los programas de dos canales nacionales durante un período de cinco horas, cinco días laborables. Se realizaron entrevistas a las madres de enero a julio de 2012, para explorar los alimentos consumidos por las madres y los niños. Para identificar las diferencias entre el número de horas de TV, el número de unidades de TV, y el número de anuncios que recordaban se realizó análisis de una vía de ANOVA. Resultados: Se observó una asociación entre el consumo de los alimentos anunciados y la frecuencia en la que se anuncian en la TV. También se observó una asociación entre las horas de televisión, el IMC de las madres y el puntaje Z-score de los niños. Conclusiones: Se observó una asociación entre las horas de televisión y los indicadores de adiposidad en las madres y los niños. El mayor aumento en la exposición a la TV puede incrementar el riesgo de obesidad infantil.

  3. [SNACK HIGH WHEY PROTEIN IMPROVES THE LEVEL OF SATIETY AND REDUCES APPETITE HEALTHY WOMEN].

    PubMed

    Reyna, Nadia; Moreno-Rojas, Rafael; Mendoza, Laura; Urdaneta, Andrés; Artigas, Carlos; Reyna, Eduardo; Cámara Martos, Fernando

    2015-10-01

    Antecedentes: el contenido nutricional y la densidad energética de los alimentos están relacionados con un mayor control del apetito, la saciedad y la reducción de la ingesta de alimentos. Material y métodos: el estudio consistió en un diseño cruzado aleatorizado que incluyó 20 mujeres sanas, con edades entre 20 y 30 años y con un IMC de 20 y 24,9 kg/m2 que se sometieron durante tres días a una prueba de ocho horas comparando meriendas de 130 kcal consumidas por la tarde: yogur con adición de proteína de suero de leche (PSL), galletas y chocolate. Consumieron un menú estandarizado; la merienda se consumía tres horas después del almuerzo. El hambre percibida y la plenitud se evaluaron durante la tarde hasta el consumo voluntario de la cena ad libitum. Resultados: el consumo de yogur con PSL ocasionó una mayor reducción del apetito y un aumento de la saciedad tras su ingesta y hasta la cena, respecto a la merienda de chocolate y galletas (p < 0,001), no existiendo diferencias entre estas últimas. La merienda de yogur con PSL ocasionó una reducción significativa de la ingesta calórica en la cena, en comparación con las otras meriendas (p < 0,001) y una solicitud más tardía de alimentos de hasta 45 minutos. Conclusiones: las meriendas con baja densidad energética y ricas en proteína (y concretamente el yogur con PSL), pueden ser una solución eficaz para mejorar el control del apetito y reducir la ingesta de alimentos en mujeres sanas.

  4. ASSOCIATION OF HELICOBACTER PYLORI INFECTION WITH NUTRITIONAL STATUS AND FOOD INTAKE.

    PubMed

    Rocha, Daianne Cristina; Sampaio, Helena Alves de Carvalho; de Oliveira Lima, José Wellington; Carioca, Antônio Augusto Ferreira; Posso Lima, Gláucia; Ribeiro de Oliveira, Ticihana; Araújo Chagas Vergara, Clarice Maria; Sousa Nunes Pinheiro, Diana Célia; Lima Herculano Júnior, José Ruver; de Pontes Ellery, Thais Helena

    2015-08-01

    Introducción: la infección por H. pylori afecta a más de la mitad de la humanidad, siendo un problema de salud pública. Su prevalencia es significativamente mayor en los países en desarrollo, como Brasil. Se ha sugerido que la infección por H. pylori puede influir en la ingesta y la homeostasis calórica. Propósito: comparar el estado nutricional y la ingesta de alimentos de los pacientes incluidos en el Sistema Nacional de Salud, con y sin infección por H. pylori. Métodos: se evaluarón 140 pacientes. Realizaron la endoscopia digestiva alta para investigar la presencia de H. pylori. Se midieron el peso corporal y la altura de los pacientes. La ingesta de alimentos se investigó a través de dos recordatorios de 24 horas, con los dados transformados en gramos y analizados en el software DietWin Professional 2.0. Los resultados se compararon mediante la prueba de chi-cuadrado o la prueba t de Student. Se adoptó de p < 0,05 como nivel de significación. Resultados: hubo predominio de pacientes con exceso de peso tanto para Hp - (60,3%) como Hp + (67,7%), sin diferencias entre ellos. La ingesta de alimentos de los grupos evaluados fue similar. Conclusiones: no hubo diferencias en el estado nutricional y la ingesta de alimentos entre los dos grupos.

  5. [Food neophobia: impact on food habits and acceptance of healthy foods in schoolchildren].

    PubMed

    Rodríguez-Tadeo, Alejandra; Patiño Villena, Begoña; Urquidez-Romero, Rene; Vidaña-Gaytán, María Elena; Periago Caston, María Jesús; Ros Berruezo, Gaspar; González Martinez-Lacuesta, Eduardo

    2014-09-21

    Introducción: En los niños la neofobia puede afectar las elecciones alimentarias y limitar la variedad de la dieta así como afectar la aceptación sensorial de nuevos alimentos. Objetivo: Identificar el impacto de la neofobia alimentaria en los hábitos alimentarios y preferencias de alimentos saludables en usuarios de comedores escolares en la ciudad de Murcia. Materiales y Métodos: Participaron 242 escolares de segundo y tercer ciclo de educación primaria, de 8-12 años, con estratificación por sexo y ciclo escolar. Se aplicó una encuesta de hábitos y preferencias alimentarias, neofobia alimentaria y aceptación de alimentos de consumo habitual en el comedor. Además se realizó una prueba sensorial y se midió el consumo de ensaladas y frutas en el comedor, mediante el método de pesada. Resultados: La prevalencia de neofobia fue de 16%, sin diferencia entre sexos, ciclo escolar, tiempo del uso del comedor, origen de los padres y tener sobrepeso o bajo peso. La neofobia se asoció a un detrimento en el consumo de verduras y frutas, el gusto por las legumbres y menor consumo de cereales y sus derivados en el desayuno y a menor preferencia de frutas, verduras y hortalizas (p.

  6. [CONTENT OF TRANS FATTY ACIDS IN FOOD PRODUCTS IN SPAIN].

    PubMed

    Robledo de Dios, Teresa; Dal Re Saavedra, M Ángeles; Villar Villalba, Carmen; Pérez-Farinós, Napoleón

    2015-09-01

    Introducción: los ácidos grasos trans están asociados con problemas de salud, como enfermedad coronaria o diabetes. Objetivos: conocer la cantidad de ácidos grasos trans en los alimentos en España, y el porcentaje que representan con respecto al total de los ácidos grasos. Métodos: se estudió el contenido en ácidos grasos de 443 alimentos adquiridos en España en el año 2010, y clasificados en grupos. Determinación analítica de grasas en los productos mediante cromatografía de gases. Se calcularon estimadores de tendencia central y dispersión de la cantidad de ácidos grasos trans en cada grupo (g de ácidos grasos trans/100 g de producto). Se calculó el porcentaje de ácidos grasos trans con respecto a la grasa total en cada grupo. Resultados: los productos se agruparon en 42 grupos. En todos, salvo uno, la mediana de ácidos grasos trans fue inferior a 0,55 g/100 g de producto. El 83 % de los grupos tienen menos del 2 % de ácidos grasos trans con respecto a las grasas totales, y el 71 %, menos del 1 %. Discusión: el contenido de AGT en los alimentos en España es bajo y no representa actualmente un problema de salud pública.

  7. Software Suite for Gene and Protein Annotation Prediction and Similarity Search.

    PubMed

    Chicco, Davide; Masseroli, Marco

    2015-01-01

    In the computational biology community, machine learning algorithms are key instruments for many applications, including the prediction of gene-functions based upon the available biomolecular annotations. Additionally, they may also be employed to compute similarity between genes or proteins. Here, we describe and discuss a software suite we developed to implement and make publicly available some of such prediction methods and a computational technique based upon Latent Semantic Indexing (LSI), which leverages both inferred and available annotations to search for semantically similar genes. The suite consists of three components. BioAnnotationPredictor is a computational software module to predict new gene-functions based upon Singular Value Decomposition of available annotations. SimilBio is a Web module that leverages annotations available or predicted by BioAnnotationPredictor to discover similarities between genes via LSI. The suite includes also SemSim, a new Web service built upon these modules to allow accessing them programmatically. We integrated SemSim in the Bio Search Computing framework (http://www.bioinformatics.deib. polimi.it/bio-seco/seco/), where users can exploit the Search Computing technology to run multi-topic complex queries on multiple integrated Web services. Accordingly, researchers may obtain ranked answers involving the computation of the functional similarity between genes in support of biomedical knowledge discovery.

  8. A Darwinian mystery: fluctuations in runoff from the la Plata basin (Alexander von Humboldt Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Clarke, R. T.

    2012-04-01

    During the voyage of HMS Beagle, Charles Darwin sailed in a small boat along the River Paraná, a major tributary of the la Plata drainage system. He wrote about the occurrence of severe droughts (the latest of which had been termed the "gran seco") alternating with periods of severe flooding. From reports received, he concluded that these events appeared to be cyclic with a period "of about fifteen years". Because extended periods of low flow in Brazilian rivers are of immense economic importance, the presentation describes a search for the material which led Darwin to this conclusion. A prolonged period of low flow in another la Plata tributary - the River Paraguay - not unlike the "gran seco" reported by Darwin, has occurred more recently; if such low flows were to recur in the future, the consequences would be severe for a region where more than 70% of energy is supplied by hydropower. A priori considerations suggest the use of statistical long-memory models for predicting River Paraguay water-levels, and some preliminary results from their use are presented.

  9. Conversion to drip irrigated agriculture may offset historic anthropogenic and wildfire contributions to sediment production.

    PubMed

    Gray, A B; Pasternack, G B; Watson, E B; Goñi, M A; Hatten, J A; Warrick, J A

    2016-06-15

    This study is an investigation into the roles of wildfire and changing agricultural practices in controlling the inter-decadal scale trends of suspended sediment production from semi-arid mountainous rivers. In the test case, a decreasing trend in suspended sediment concentrations was found in the lower Salinas River, California between 1967 and 2011. Event to decadal scale patterns in sediment production in the Salinas River have been found to be largely controlled by antecedent hydrologic conditions. Decreasing suspended sediment concentrations over the last 15years of the record departed from those expected from climatic/hydrologic forcing. Sediment production from the mountainous headwaters of the central California Coast Ranges is known to be dominated by the interaction of wildfire and large rainfall/runoff events, including the Arroyo Seco, an ~700km(2) subbasin of the Salinas River. However, the decreasing trend in Salinas River suspended sediment concentrations run contrary to increases in the watershed's effective burn area over time. The sediment source area of the Salinas River is an order of magnitude larger than that of the Arroyo Seco, and includes a more complicated mosaic of land cover and land use. The departure from hydrologic forcings on suspended sediment concentration patterns was found to coincide with a rapid conversion of irrigation practices from sprinkler and furrow to subsurface drip irrigation. Changes in agricultural operations appear to have decreased sediment supply to the Salinas River over the late 20th to early 21st centuries, obscuring the influence of wildfire on suspended sediment production.

  10. HEMISPHERIC CENTER FOR ENVIRONMENTAL TECHNOLOGY

    SciTech Connect

    M.A. Ebadian

    2000-01-31

    The Online Measurement of Decontamination project team received a commitment for a demonstration in May from the Sacramento (California) Municipal Utility District (SMUD) Rancho Seco site. Since this site is a member of the DOE Commercial Utilities Consortium, the demonstration will fulfill the DOE and commercial technology demonstration requirements. Discussion on deployment of the Integrated Vertical and Overhead Decontamination (IVOD) System at Rancho Seco was conducted; date for deployment tentatively scheduled for early spring. Based upon fictional requirements from SRS for a shiny monitor in a high-level waste tank, FIU-HCET developed and delivered a draft slurry monitor design and draft test plan. Experiments measuring slurry settling time for SRS slurry simulant at 10 wt% have been completed on FIU-HCET'S flow loop with SRS dip. The completed design package of the test mockup for evaluating Non-Intrusive Location of Buried Items Technologies was sent to Fluor Fernald and the Operating Engineers National Hazmat Program for review. Comments are due at the end of January. Preliminary experiments to determine size distribution of aerosols generated during metal cutting were performed. A 1/4-inch-thick iron plate was cut using a plasma arc torch, and the size distribution of airborne particles was measured using a multistage impactor. Per request of DOE-Ohio, FIU-HCET participated in a weeklong value engineering study for the characterization, decontamination, and dismantlement of their critical path facility.

  11. Biotransformation of ent-kaur-16-ene and ent-trachylobane 7β-acetoxy derivatives by the fungus Gibberella fujikuroi (Fusarium fujikuroi).

    PubMed

    Fraga, Braulio M; Bressa, Carlo; González-Vallejo, Victoria; González, Pedro; Guillermo, Ricardo

    2012-09-01

    Candol A (7β-hydroxy-ent-kaur-16-ene) (6) is efficiently transformed by Gibberella fujikuroi into the gibberellin plant hormones. In this work, the biotransformation of its acetate by this fungus has led to the formation of 7β-acetoxy-ent-kaur-16-en-19-oic acid (3), whose corresponding alcohol is a short-lived intermediate in the biosynthesis of gibberellins and seco-ring ent-kaurenoids in this fungus. Further biotransformation of this compound led to the hydroxylation of the 3β-positions to give 7β-acetoxy-3β-hydroxy-ent-kaur-16-en-19-oic acid (14), followed by a 2β- or 18-hydroxylation of this metabolite. The incubation of epicandicandiol 7β-monoacetate (7β-acetoxy-18-hydroxy-ent-kaur-16-ene) (10) produces also the 19-hydroxylation to form the 18,19 diol (20), which is oxidized to give the corresponding C-18 or C-19 acids. These results indicated that the presence of a 7β-acetoxy group does not inhibit the fungal oxidation of C-19 in 7β-acetoxy-ent-kaur-16-ene, but avoids the ring B contraction that leads to the gibberellins and the 6β-hydroxylation necessary for the formation of seco-ring B ent-kaurenoids. The biotransformation of 7β-acetoxy-ent-trachylobane (trachinol acetate) (27) only led to the formation of 7β-acetoxy-18-hydroxy-ent-trachylobane (33).

  12. The microbiological transformation of 7alpha-hydroxy-ent-kaur-16-ene derivatives by Gibberella fujikuroi.

    PubMed

    Fraga, Braulio M; Bressa, Carlo; González, Pedro; Guillermo, Ricardo; Hernández, Melchor G; Suárez, Sergio

    2007-06-01

    The biotransformation of 7alpha-hydroxy-ent-kaur-16-ene (epi-candol A) by the fungus Gibberella fujikuroi gave 7alpha,16alpha,17-trihydroxy-ent-kaur-16-ene and a seco-ring B derivative, fujenoic acid, whilst the incubation of candicandiol (7alpha,18-dihydroxy-ent-kaur-16-ene) and canditriol (7alpha,15alpha,18-trihydroxy-ent-kaur-16-ene) afforded 7alpha,18,19-trihydroxy-ent-kaur-16-ene and 7alpha,11beta,15alpha,18-tetrahydroxy-ent-kaur-16-ene, respectively. The presence of a 7alpha-hydroxyl group in epi-candol A avoids its biotransformation along the biosynthetic pathway of gibberellins, and directs it to the seco-ring B acids route. The 15alpha-hydroxyl group in canditriol inhibits oxidation at C-19 and direct hydroxylation at C-11(beta). The formation of fujenoic acid, from 7alpha-hydroxy-ent-kaur-16-ene, probably occurs via 7alpha-hydroxykaurenoic acid and 7-oxokaurenoic acid, with subsequent hydroxylation at the C-6(beta) position.

  13. Cross-species malaria immunity induced by chemically attenuated parasites

    PubMed Central

    Good, Michael F.; Reiman, Jennifer M.; Rodriguez, I. Bibiana; Ito, Koichi; Yanow, Stephanie K.; El-Deeb, Ibrahim M.; Batzloff, Michael R.; Stanisic, Danielle I.; Engwerda, Christian; Spithill, Terry; Hoffman, Stephen L.; Lee, Moses; McPhun, Virginia

    2013-01-01

    Vaccine development for the blood stages of malaria has focused on the induction of antibodies to parasite surface antigens, most of which are highly polymorphic. An alternate strategy has evolved from observations that low-density infections can induce antibody-independent immunity to different strains. To test this strategy, we treated parasitized red blood cells from the rodent parasite Plasmodium chabaudi with seco-cyclopropyl pyrrolo indole analogs. These drugs irreversibly alkylate parasite DNA, blocking their ability to replicate. After administration in mice, DNA from the vaccine could be detected in the blood for over 110 days and a single vaccination induced profound immunity to different malaria parasite species. Immunity was mediated by CD4+ T cells and was dependent on the red blood cell membrane remaining intact. The human parasite, Plasmodium falciparum, could also be attenuated by treatment with seco-cyclopropyl pyrrolo indole analogs. These data demonstrate that vaccination with chemically attenuated parasites induces protective immunity and provide a compelling rationale for testing a blood-stage parasite-based vaccine targeting human Plasmodium species. PMID:23863622

  14. Anti-inflammatory triterpenoids from the stems of Microtropis fokienensis.

    PubMed

    Chen, I-Hsiao; Du, Ying-Chi; Hwang, Tsong-Long; Chen, I-Fen; Lan, Yu-Hsuan; Yen, Hsin-Fu; Chang, Fang-Rong; Wu, Yang-Chang

    2014-01-01

    Three new ursane- and four new oleanane- type triterpenoids 1-7 were isolated, along with six known compounds 8-13, from the methanolic extract of Microtropis fokienensis. All structures were elucidated by mass and NMR spectroscopic methods. The isolates 4-10 and known compounds 14-17 that were previously isolated from this material were evaluated for anti-inflammatory activity based on effects against superoxide anion generation and elastase release by neutrophils in response to fMLP/CB. 11α,30-Dihydroxy-2,3-seco-olean-12-en-2,3-dioic anhydride (7) was the first triterpene anhydride from the genus of Microtropis to have the ring A expanded to a seven-membered ring; it showed significant anti-inflammatory activity against superoxide anion generation and elastase release. Unexpectedly, 30-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (17) showed the best effect against superoxide anion generation and elastase release with IC50 values of 0.06±0.01 and 1.03±0.35 µg/mL, respectively. Compound 17 had a dioic acid function, and compound 7 had an anhydride function modification in ring A; both showed promising activity in the target assays.

  15. Software Suite for Gene and Protein Annotation Prediction and Similarity Search.

    PubMed

    Chicco, Davide; Masseroli, Marco

    2015-01-01

    In the computational biology community, machine learning algorithms are key instruments for many applications, including the prediction of gene-functions based upon the available biomolecular annotations. Additionally, they may also be employed to compute similarity between genes or proteins. Here, we describe and discuss a software suite we developed to implement and make publicly available some of such prediction methods and a computational technique based upon Latent Semantic Indexing (LSI), which leverages both inferred and available annotations to search for semantically similar genes. The suite consists of three components. BioAnnotationPredictor is a computational software module to predict new gene-functions based upon Singular Value Decomposition of available annotations. SimilBio is a Web module that leverages annotations available or predicted by BioAnnotationPredictor to discover similarities between genes via LSI. The suite includes also SemSim, a new Web service built upon these modules to allow accessing them programmatically. We integrated SemSim in the Bio Search Computing framework (http://www.bioinformatics.deib. polimi.it/bio-seco/seco/), where users can exploit the Search Computing technology to run multi-topic complex queries on multiple integrated Web services. Accordingly, researchers may obtain ranked answers involving the computation of the functional similarity between genes in support of biomedical knowledge discovery. PMID:26357324

  16. Metabolite Diversity in Alkaloid Biosynthesis: A Multilane (Diastereomer) Highway for Camptothecin Synthesis in Camptotheca acuminata.

    PubMed

    Sadre, Radin; Magallanes-Lundback, Maria; Pradhan, Sujana; Salim, Vonny; Mesberg, Alex; Jones, A Daniel; DellaPenna, Dean

    2016-08-01

    Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by combining transcriptome and expression data with reverse genetics, biochemistry, and metabolite profiling. RNAi silencing of enzymes required for the indole and seco-iridoid (monoterpene) components identified transcriptional crosstalk coordinating their synthesis in roots. Metabolite profiling and labeling studies of wild-type and RNAi lines identified plausible intermediates for missing pathway steps and demonstrated nearly all camptothecin pathway intermediates are present as multiple isomers. Unlike previously characterized MIA-producing plants, C. acuminata does not synthesize 3-α(S)-strictosidine as its central MIA intermediate and instead uses an alternative seco-iridoid pathway that produces multiple isomers of strictosidinic acid. NMR analysis demonstrated that the two major strictosidinic acid isomers are (R) and (S) diastereomers at their glucosylated C21 positions. The presence of multiple diastereomers throughout the pathway is consistent with their use in synthesis before finally being resolved to a single camptothecin isomer after deglucosylation, much as a multilane highway allows parallel tracks to converge at a common destination. A model "diastereomer" pathway for camptothecin biosynthesis in C. acuminata is proposed that fundamentally differs from previously studied MIA pathways. PMID:27432874

  17. Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr.

    PubMed

    Yang, Xian-Wen; Feng, Lin; Li, Su-Mei; Liu, Xiao-Hua; Li, Yong-Li; Wu, Liang; Shen, Yun-Heng; Tian, Jun-Mian; Zhang, Xi; Liu, Xin-Ru; Wang, Ning; Liu, Yonghong; Zhang, Wei-Dong

    2010-01-15

    Twenty-five new (abiesadines A-Y, 1-25) and 29 known (26-54) diterpenes were isolated from the aerial parts of Abies georgei. Abiesadine A (1) is a novel 8,14-seco-abietane, while abiesadine B (2) is a novel 9,10-seco-abietane. The structures of the new compounds were established on the basis of spectroscopic data analysis. Manool (52) showed the strongest effect against LPS-induced NO production in RAW264.7 macrophages with the IC(50) value of 11.0microg/mL. In another anti-inflammatory assay against TNFalpha-triggered NF-kappaB activity, (12R,13R)-8,12-epoxy-14-labden-13-ol (54) exhibited the strongest effect (IC(50)=8.7microg/mL). For antitumor assays, pomiferin A (26) and 8,11,13-abietatriene-7alpha,18-diol (29) both showed the most significant activity against LOVO cells (IC(50)=9.2microg/mL). While 7-oxocallitrisic acid (46) exhibited significant cytotoxicity against QGY-7703 tumor cells (IC(50)=10.2microg/mL).

  18. The density and species of mite breeding in stored products in China.

    PubMed

    Li, Chaopin; Zhan, Xiaodong; Sun, Entao; Zhao, Jinhong; Wang, Huiyong; He, Ji; Wang, Jiajia; He, Lianping

    2014-09-12

    Objetivo: El objetivo de nuestro estudio fue investigar las especies y la densidad de reproducción de ácaros en productos almacenados en China. Métodos: Provisionalmente, se recogieron muestras de productos almacenados en naves, locales comerciales y viviendas. Resultados: Los resultados sugirieron que los ácaros varíaban mucho en cuanto a especies respecto a sus hábitos y habitats ecológicos. Aún así, la densidad de reproducción en distintas muestras estuvo asociada a las condiciones de muestreo. Conclusiones: Estas discrepancias pueden estar asociadas con las muestras recogidas en diversos ambientes para los ácaros, y los resultados sugieren visiblemente que los ácaros tienen una distribución universal.

  19. PubMed

    Yunta, Eduardo Rodríguez

    2010-01-01

    El presente artículo reflexiona desde los 4 principios de la bioética el uso comercial de organismos genéticamente modificados. Se cuestiona fundamentalmente la falta de transferencia de tecnología entre el mundo desarrollado y en desarrollo y el que el presente sistema de patentamiento de organismos vivos modificados fomenta intereses comerciales y no da debida importancia al desarrollo sostenible de la agricultura y ganadería en los países en desarrollo, donde más se necesita. Se reflexiona sobre la importancia que tiene evaluar los riesgos antes de introducirse en el mercado organismos genéticamente modificados y la necesidad de regulación en los países.

  20. Sea cucumber species identification of family Caudinidae from Surabaya based on morphological and mitochondrial DNA evidence

    NASA Astrophysics Data System (ADS)

    Amin, Muhammad Hilman Fu'adil; Pidada, Ida Bagus Rai; Sugiharto, Widyatmoko, Johan Nuari; Irawan, Bambang

    2016-03-01

    Species identification and taxonomy of sea cucumber remains a challenge problem in some taxa. Caudinidae family of sea cucumber was comerciallized in Surabaya, and it was used as sea cucumber chips. Members of Caudinid sea cucumber have similiar morphology, so it is hard to identify this sea cucumber only from morphological appearance. DNA barcoding is useful method to overcome this problem. The aim of this study was to determine Caudinid specimen of sea cucumber in East Java by morphological and molecular approach. Sample was collected from east coast of Surabaya, then preserved in absolute ethanol. After DNA isolation, Cytochrome Oxydase I (COI) gene amplification was performed using Echinoderm universal primer and PCR product was sequenced. Sequencing result was analyzed and identified in NCBI database using BLAST. Results showed that Caudinid specimen in have closely related to Acaudina molpadioides sequence in GenBank with 86% identity. Morphological data, especially based on ossicle, also showed that the specimen is Acaudina molpadioides.

  1. Reflexión bioética sobre el uso de organismos genéticamente modificados

    PubMed Central

    Yunta, Eduardo Rodríguez

    2011-01-01

    El presente artículo reflexiona desde los 4 principios de la bioética el uso comercial de organismos genéticamente modificados. Se cuestiona fundamentalmente la falta de transferencia de tecnología entre el mundo desarrollado y en desarrollo y el que el presente sistema de patentamiento de organismos vivos modificados fomenta intereses comerciales y no da debida importancia al desarrollo sostenible de la agricultura y ganadería en los países en desarrollo, donde más se necesita. Se reflexiona sobre la importancia que tiene evaluar los riesgos antes de introducirse en el mercado organismos genéticamente modificados y la necesidad de regulación en los países. PMID:21927675

  2. PubMed

    Yunta, Eduardo Rodríguez

    2010-01-01

    El presente artículo reflexiona desde los 4 principios de la bioética el uso comercial de organismos genéticamente modificados. Se cuestiona fundamentalmente la falta de transferencia de tecnología entre el mundo desarrollado y en desarrollo y el que el presente sistema de patentamiento de organismos vivos modificados fomenta intereses comerciales y no da debida importancia al desarrollo sostenible de la agricultura y ganadería en los países en desarrollo, donde más se necesita. Se reflexiona sobre la importancia que tiene evaluar los riesgos antes de introducirse en el mercado organismos genéticamente modificados y la necesidad de regulación en los países. PMID:21927675

  3. [Oral anaphylaxis by ingestion of mite contaminated food in Panama City, 2011-2014].

    PubMed

    Barrera, Olga M; Murgas, Ingrid L; Bermúdez, Sergio; Miranda, Roberto J

    2015-01-01

    Antecedentes: la anafilaxia oral por ácaros, o síndrome de las panquecas, ocurre cuando individuos atópicos ingieren alimentos elaborados con harina de trigo contaminada con ácaros, lo que induce reacciones alérgicas moderadas o severas, incluso fatales. Los reportes provienen de ambientes tropicales y subtropicales, donde las condiciones para la proliferación de ácaros domésticos son favorables. Se ha encontrado una asociación importante con la hipersensibilidad a ácido acetilsalicílico (AAS)-antiinflamatorios no esteroides (AINES) y el ejercicio físico. Objetivo: documentar el estudio clínico y descriptivo de casos de anafilaxia oral por ácaros atendidos en Ciudad de Panamá durante los años 2011 a 2014. Material y método: estudio clínico descriptivo y retrospectivo, que incluyó pruebas cutáneas de punción para cinco especies de ácaros domésticos. La identificación taxonómica de los ácaros se realizó bajo microscopio y se calculó la densidad de ácaros por gramo de alimento en tres casos. Resultados: se estudiaron 10 casos compatibles con anafilaxia oral por ácaros, la panqueca fue el alimento implicado con más frecuencia. Los primeros síntomas aparecieron entre 25 y 60 minutos después de la ingestión del alimento. Todos los pacientes fueron adultos jóvenes atópicos, cuatro con hipersensibilidad a AAS-AINES. Los pacientes resultaron positivos a las pruebas cutáneas de punción para los ácaros: Blomia tropicalis, Dermatophagoides pteronyssinus y Suidasia pontifica. Tres muestras de harina de trigo estudiadas motraron altas densidades de ácaros. Conclusiones: la panqueca fue el alimento implicado con más frecuencia en los casos de anafilaxia oral por ácaros. Suidasia pontifica y Blomia tropicalis parecen ser los ácaros más importantes relacionados con este síndrome en nuestro país.

  4. [Oral chemotherapy: food-drug interactions].

    PubMed

    Santana Martínez, Sara; Marcos Rodríguez, José Antonio; Romero Carreño, Elia

    2015-07-01

    Introducción: el uso de citostáticos orales está cada vez más extendido en oncología. Presenta ventajas importantes, como la comodidad para el paciente, pero también supone nuevos retos que no se planteaban con la terapia intravenosa. Algunos de estos fármacos presentan interacciones con los alimentos, dando lugar a cambios en su biodisponibilidad. Al tratarse de fármacos de estrecho margen terapéutico, pueden dar lugar a alteraciones en su eficacia y/o toxicidad. Objetivos: evaluar el nivel de conocimiento sobre el modo de administración por parte de los pacientes que acuden a la consulta de pacientes externos de oncohematología del hospital de aquellos citostáticos orales que presentan alguna restricción respecto a su consumo con alimentos (deben tomarse o bien en ayunas. o bien con alimentos). Minimizar al máximo la administración incorrecta de los citostáticos dispensados y el riesgo de que se produzcan interacciones con los alimentos, proporcionando información a los pacientes acerca del modo correcto de administración. Material y métodos: una vez identificados los citostáticos orales con restricciones respecto a su consumo con alimentos, además de la información aportada por farmacia, se preguntó a los pacientes la información que habían recibido por parte del médico acerca de cómo debía administrarse el fármaco, el modo en que se lo tomaban finalmente y, en caso de no hacerlo adecuadamente, se les reforzó la información pertinente. En el siguiente ciclo se confirmó si efectivamente el paciente se lo administraba correctamente, en caso de hacerlo previamente de forma incorrecta (intervención aceptada/no aceptada). Resultados y conclusiones: un 40% de los pacientes entrevistados se administraban el fármaco incorrectamente. Los resultados muestran una gran diversidad en función del fármaco dispensado. Se realizaron un total de 39 intervenciones, que fueron aceptadas en un 95%. Los datos obtenidos sugieren la necesidad de

  5. [Are antioxidant supplements effective in reducing delayed onset muscle soreness? A systematic review].

    PubMed

    Candia-Luján, Ramón; De Paz Fernández, José Antonio; Costa Moreira, Osvaldo

    2014-10-05

    Introducción: En los últimos años los suplementos antioxidantes han cobrado popularidad para contrarrestar los efectos de los radicales libres y los síntomas del daño muscular, entre los que se encuentra el dolor muscular tardío (DMT). Objetivo: realizar una revisión sistemática en diferentes bases de datos para conocer los efectos de los suplementos antioxidantes sobre el DMT. Método: Se llevó a cabo una búsqueda en las bases de datos; Cochrane Library, Pubmed, Scopus y SportDiscus y la Web Of Science (WOS). Las palabras y acrónimos usados fueron; Delayed onset muscle soreness, exercise induced muscle damage, DOMS, EIMD, antioxidant y oxidative stress. Resultados: Se identificaron 54 artículos de los cuales se recuperaron 48, todos ellos en inglés, 17 relacionados con la vitamina C y E, catorce corresponden a suplementos polifenòlicos, once a otros suplementos antioxidantes y seis a suplementos comerciales todos ellos usados para combatir, entre otras variables, el DMT. Conclusiones: Tanto las vitaminas como los suplementos comerciales presentan baja efectividad en la disminución del DMT, mientras que los polifenoles y otros suplementos antioxidantes muestran entre moderada y buena efectividad en el combate al DMT. Sin embargo, gran parte de los estudios presentan efectividad en la disminución de otros síntomas del daño muscular además de ayudar en la recuperación postejercicio.

  6. From Cassyrane to cashmeran - the molecular parameters of odorants.

    PubMed

    Kraft, Philip; Di Cristofaro, Valeria; Jordi, Samuel

    2014-10-01

    This review, including some new experimental results, is the summary of a talk at the 'flavors & fragrances 2013' conference in Leipzig, organized jointly by the GDCh, the Liebig-Vereinigung, and the EuCheMS. After times of searching for natural odor principles and serendipitous discoveries by chemical inspiration, directed odorant design today offers the highest hit rates for the discovery of new odorants, although serendipity still plays a role. Keeping intact the electronic shape required for a certain olfactophore-binding geometry, one can add or subtract structural elements, rigidify molecular structures, or introduce more structural flexibility. To find out which structural features are critical, the 'seco-approach', in which different fragments are removed by cutting strategic bonds, is the most analytical. Following this approach, such ingredients as Serenolide, Sylkolide, and Pomarose were designed. Transferring this design principle from the family of damascones to that of the theaspiranes led to the discovery of Cassyrane, though completely different structural features turned out to be relevant. Application of the seco-concept to a 3,7a-substituted 2,6,7,7a-tetrahydro-1H-inden-5-yl musk lead structure derived from carotol resulted in the discovery of a new family of dienone musks with novel structure-odor correlations. However, cutting the C(2)-O bond of Cassyrane and oxidizing the resulting seco-structure to the 1,2,5,1″-tetradehydro derivative links the family of dienone musks with that of blackcurrant odorants, but the resulting target structures turned out to be potent orris odorants. (3E,5E)-5-(tert-Butyl)octadeca-3,5-dien-2-one even possesses the lowest odor threshold in the whole ionone family (0.036 ng/l air), which could be rationalized by a superposition analysis on (-)-cis-γ-irone. In the course of the synthesis of these high-impact orris odorants, we discovered that, depending on the reaction conditions, the dehydration step of the

  7. The Role of Wildfire in the Export of Particulate and Pyrogenic Organic Carbon from a Small Mountainous River

    NASA Astrophysics Data System (ADS)

    Hatten, J.; Warrick, J.; Goni, M.; Wheatcroft, R.; Pasternack, G.; Gray, A.; Watson, E.

    2012-04-01

    The delivery of particulate organic carbon (POC) from rivers to marine sediments is the major long-term sink of CO2 on Earth and a net source of oxygen over millennial time scales. Small mountainous river systems (SMRS) may be responsible for half of the POC delivery to global oceans. The flux of POC in SMRS has been thought to be regulated by hydro-geomorphic factors, such as runoff, tectonic uplift rates, and bedrock geology. To date, the role of landscape disturbances such as fire has not been investigated. Two large wildfires (1977 and 2008) in the chaparral-dominated Arroyo Seco watershed of California provided a unique opportunity to examine the effects of fire on sediment and POC flux at the watershed-scale. Suspended sediments were measured before and after both fires while POC was measured after the 2008 wildfire. Relationships between sediment and sediment carbon concentration of the 2008 fire were used to determine POC flux as a result of the earlier 1977 fire. For two years after the 2008 Basin Complex POC fluxes were 25 and 50 times more than would be expected during a non-fire affected year (5.9 and 59.7 Mg/sq. km/yr during 2009 and 2010, respectively, versus 1.1 M/sq. km/yr-1 during non-fire year). This was driven fire caused increases in suspended sediment flux and an increase in suspended sediment carbon concentration. Flux weighted average organic carbon concentrations of suspended sediment collected from the Arroyo Seco River after the 2008 Basin Complex wildfire were over 3.2 times higher than pre-fire levels. Using a Monte Carlo analysis of fire and flooding we determine that over the long-term fire caused erosion and hydrological change is responsible for over 90% of the POC flux. Elemental, stable isotope, and biomarker analyses show that both burned and unburned organic matter has contributed to the elevated carbon concentrations as a result of enhanced surface erosion processes. Our preliminary results suggest that 25% of the POC discharged

  8. The Role of Wildfire in the Export of Particulate Organic Carbon from a Small Mountainous River

    NASA Astrophysics Data System (ADS)

    Hatten, J. A.; Warrick, J. A.; Goni, M. A.; Wheatcroft, R. A.; Pasternack, G. B.; Gray, A. B.; Watson, E. B.

    2011-12-01

    The delivery of particulate organic carbon (POC) from rivers to marine sediments is the major long-term sink of CO2 on Earth and a net source of oxygen over millennial time scales. Small mountainous river systems may be responsible for half of the POC delivery to global oceans. The flux of POC in SMRS has been thought to be regulated by hydro-geomorphic factors, such as runoff, tectonic uplift rates, and bedrock geology. To date, the role of landscape disturbances, such as fire, have not been fully investigated. Two large wildfires (1977 and 2008) in the chaparral-dominated Arroyo Seco watershed of California provided a unique opportunity to examine the effects of fire on sediment and POC flux at the watershed-scale. Suspended sediments were measured before and after both fires while POC was measured after the 2008 wildfire. Relationships between sediment and sediment carbon concentration of the 2008 fire were used to determine POC flux as a result of the earlier 1977 fire. Particulate organic carbon concentrations of suspended sediment collected from the Arroyo Seco River after the 2008 Basin Complex wildfire were over 6 and 2 times larger than pre-fire levels during year 1 and 2, respectively. The 2008 Basin Complex wildfire was followed by a drier than normal year, and POC fluxes were 39 and 34 times more than would be expected during a non-fire affected year. Biomarker analyses of the suspended sediment from the Arroyo Seco River shows that both burned and unburned organic matter has contributed to the elevated carbon concentrations, probably as a result of enhanced surface erosion processes. The 1977 fire was followed by a very wet year and POC fluxes were 96 times larger than would be expected during a non-fire affected year. Using a Monte Carlo analysis of fire and flooding we determine that over the long-term fire is responsible for over an order of magnitude more POC export than flooding alone. While these fire-flood events may be rare, POC yield will be

  9. Provenance of metasedimentary rocks of the Western Pernambuco-Alagoas Domain: Contribution to understand the crustal evolution of southern Borborema Province

    NASA Astrophysics Data System (ADS)

    Cruz, Rodrigo Fabiano da; Pimentel, Márcio Martins; Accioly, Ana Cláudia de Aguiar

    2014-12-01

    The Borborema Province is a complex neoproterozoic orogen in northeastern Brazil, made of a mosaic of fault-bounded terrains and several metassedimentary sequences. In the present work, new zircon U-Pb provenance data for metasedimentary rocks in the Western Pernambuco-Alagoas Domain, southern part of the Province, are reported. Detrital zircon ages range from Archean to Neoproterozoic. Three samples of the Cabrobó Complex were investigated: (i) sillimanite-kyanite-garnet-biotite schist, which presented mostly Ediacaran and Cryogenian detrital zircon ages (youngest zircon at ca. 554 Ma) indicating erosion of neoproterozoic sources, (ii) garnet-biotite schist, which has a dominant Tonian/Stenian population, a less abundant Cryogenian (youngest zircon age at ca. 643 Ma) as well as Paleoproterozoic and Archean zircon grains, and (iii) tourmaline-muscovite quartzite, which contains detrital zircon varying in age between ca. 2.08 Ga and 1.57 Ga, and an abundant population close to the Meso/Paleoproterozoic boundary, possibly associated with the erosion of rocks formed during the Statherian taphrogenesis, known in the central part of the São Francisco Craton as well as in other areas of the Borborema Province. Two samples of the Riacho Seco Metasedimentary Complex were also investigated: (i) a biotite schist with a dominant population presenting ages mostly between 2.3 and 2.7 Ga (youngest zircon age at ca. 2023 Ma) and (ii) a magnetite-biotite-muscovite quartzite, having detrital zircon grains with ages ranging between ca. 1.9 and 2.7 Ga. The sedimentary rocks of the Riacho Seco Complex may have their origin related to the erosion of sources within the São Francisco Craton. The data for the Riacho Seco metasedimentary rocks, however, are not conclusive with respect to the depositional age of the original sedimentary rocks. The sequence might represent exposure of an old (Paleoproterozoic) sedimentary pile or, alternatively, it comprises a neoproterozoic passive

  10. Development of Satellite Remote Sensing Techniques for Quantifying Volcanic Ash Cloud Properties

    NASA Astrophysics Data System (ADS)

    Pavolonis, Michael J.

    Novel new approaches to automatically detect and characterize volcanic ash using satellite data are presented. The Spectrally Enhanced Cloud Objects (SECO) ash detection algorithm, combines radiative transfer theory, Bayesian methods, and image processing/computer vision concepts to identify volcanic ash clouds in satellite data with skill that is generally comparable to a human expert, especially with respect to false alarm rate. The SECO method is globally applicable and can be applied to virtually any low earth orbit or geostationary satellite sensor. The new ash detection approach was quantitatively proven to be significantly more skillful than traditional pixel based approaches, including the commonly used "split-window" technique. The performance of the SECO approach is extremely promising and well suited for a variety of new and improved applications. A new approach to retrieve volcanic ash cloud properties from infrared satellite measurements was also developed. The algorithm utilizes an optimal estimation framework to retrieve ash cloud height, mass loading, and effective particle radius. Optimal estimation allows uncertainties in the measurements and forward model to be taken into account and uncertainty estimates for each of the retrieved parameters to be determined. Background atmospheric water vapor, surface temperature, and surface emissivity are explicitly accounted for on a pixel-by-pixel basis, so the algorithm is globally applicable. In addition, the ash cloud retrieval algorithm is unique because it allows the cloud temperature/height to be a free parameter. Volcanic ash clouds are a major aviation hazard. Fine-grained ash from explosive eruptions can be transported long distances (>1000 km) from the source volcano by atmospheric winds, severely disrupting aviation operations. Volcanic ash clouds are complex and the background environment in which they reside can be as well. Thus, sophisticated satellite remote sensing techniques for extracting

  11. Effect of the intake of liquids rich in polyphenols on blood pressure and fat liver deposition in rats submitted to high-fat diet.

    PubMed

    Palmisciano Bedê, Teresa; Pascoal, Ana Cláudia; Hauaji Facó, Lucas; de Salvo Castro, Eduardo; Mattoso, Vânia; Furtado Dias, Juliana; Blondet de Azeredo, Vilma

    2015-06-01

    Introducción: en busca de una mejor calidad de vida, crece el número de estudios sobre alimentos funcionales y la prevención de enfermedades. Destacan el jugo de uva roja (JU) y el vino tinto (VT), que son ricos en polifenoles, y tienen efecto antioxidante y antiinflamatorio. Objetivo: evaluar el efecto de la ingesta de JU, VT y solución de resveratrol (SR) sobre la presión arterial y la deposición de grasa hepática en ratas alimentadas con una dieta rica en grasas. Métodos: durante 60 días, 50 adultos de Rattus norvegicus Wistar Albino fueron divididos en grupos: control (GC) - dieta equilibrada y hiperlipídica (GH), vino tinto (GV), jugo de uva (JV) y resveratrol (GR) - dieta rica en grasas. El alimento y el agua se ofrecieron ad libttum a todos los grupos. JU, VT y SR se ofrecen diariamente a la GS, GV y GR, respectivamente. Se midió la presión arterial en la cola mediante manguito inflable. Los animales fueron anestesiados y sacrificados y se les extirpó el hígado, que fue pesado y del cual se extrajo la grasa con el extractor Soxhlet. Resultados: no hubo diferencia en la ganancia de peso, consumo de alimento, peso del hígado y presión arterial diastólica entre los grupos. Sin embargo, la presión arterial sistólica (mmHg) y la concentración de grasa en el hígado (g%) fueron menores (p.

  12. [Prevalence of sensitization to cow's milk and egg among patients with suspicion of IgE mediated diseases].

    PubMed

    Mopan, José; Sánchez, Jorge; Chinchilla, Carlos; Cardona, Ricardo

    2015-01-01

    Antecedentes: en Latinoamérica existen muy pocos datos epidemiológicos de alergia alimentaria y sensibilización a leche o huevo. Objetivo: describir la frecuencia de sensibilización a leche y huevo en una población con sospecha de enfermedades mediadas por IgE. Material y método: estudio retrospectivo y descriptivo de pacientes que consultaron a un servicio de Alergología, con sospecha de exacerbación con ciertos alimentos. Todos los pacientes seleccionados tenían pruebas cutáneas con leche y huevo y otros alimentos sospechosos; además, tenían una historia clínica completa que permitía correlacionar el resultado con la comorbilidad del paciente. Resultados: la sensibilización a un alimento ocurrió en 29.7% de los pacientes. La sensibilización a huevo se observó en 6.1% de los pacientes y se asoció de manera significativa con asma, rinitis y eosinofilia gastrointestinal, especialmente en menores de cinco años, mientras que la sensibilización a leche se observó en 4.5% y no se asoció con ninguno de los fenotipos estudiados. Conclusiones: en Colombia, la sensibilización a leche y huevo es relativamente baja comparada con lo reportado en otros estudios en población con riesgo de sensibilización. Sin embargo, la sensibilización temprana a huevo podría ser un marcador de mal pronóstico en los pacientes atópicos.

  13. [Not Available].

    PubMed

    Vio, Fernando; Lera, Lydia; Salinas, Judith

    2016-01-01

    Objetivo: mediante la técnica de consenso Delphi, conocer la opinión de un grupo de expertos en nutrición, educación y gastronomía para buscar consenso sobre metodologías educativas en alimentación saludable, alumnos de tercero a quinto año básico, sus familias y profesores.Métodos: con los resultados de encuestas y grupos focales realizados previamente a niños, padres y profesores, se elaboró un cuestionario que fue enviado a 51 expertos en nutrición, educación y gastronomía en una primera ronda. Los resultados fueron analizados y reenviados en una segunda ronda con las preguntas no consensuadas, obteniendo 38 respuestas.Resultados: hubo consenso en que se pueden cambiar hábitos en escuelas mediante talleres de cocina con chefs o monitores, educación activo-participativa y huertos escolares. Padres y profesores deben tener habilidades culinarias saludables para educar a los niños. Estos deben hacer uso racional del dinero en la escuela. Para ello es necesario cambiar la oferta del kiosko hacia alimentos saludables, o suprimirlo si no es saludable. Los profesores deben capacitarse con talleres de autocuidado y vida sana para educar en alimentación saludable a los niños en horarios de clase con material educativo, talleres de cocina con recetas y aprovechar horarios de desayuno y almuerzo para actividades educativas. Los padres deben participar en talleres para escoger alimentos saludables en lugares de venta y preparar menús saludables. Los niños deben aprender habilidades culinarias simples, preparando y degustando alimentos saludables. Conclusiones: estos resultados son fundamentales para diseñar materiales educativos en alimentación saludable que cambien los malos hábitos alimentarios actuales. PMID:27571651

  14. Validation of a semi-quantitative food frequency questionnaire to assess food groups and nutrient intake.

    PubMed

    Macedo-Ojeda, Gabriela; Vizmanos-Lamotte, Barbara; Márquez-Sandoval, Yolanda Fabiola; Rodríguez-Rocha, Norma Patricia; López-Uriarte, Patricia Josefina; Fernández-Ballart, Joan D

    2013-11-01

    Introducción. Los cuestionarios semicuantitativos de frecuencia de consumo (CFC) analizan ingestión promedio de alimentos y nutrimentos en períodos extensos para asociar consumo habitual con problemas de salud, como enfermedades crónicas. En México, no existe una herramienta similar, aplicable en mujeres y hombres. Objetivo. Validar un CFC en mujeres y hombres adultos. Métodos. El estudio incluyó 97 participantes (61% mujeres). Dos CFC fueron aplicados (un año entre ambos) para medir reproducibilidad. Para validez, se comparó el segundo CFC con registros dietéticos de nueve días. Los análisis incluyeron correlaciones de Pearson y coeficientes de correlación intraclase (CCI). Se controló desatenuación de CCI provocada por la variabilidad intraindividual. El análisis de validez se complementó con la comparación de la capacidad de clasificación entre CFC y registros dietéticos, mediante concordancia de categorías de consumo y gráficos de Bland y Altman. Resultados. Reproducibilidad: los CCI para grupos de alimentos oscilaron entre 0.42-0.87 y para nutrimentos entre 0.34-0.82. Validez: los CCI para grupos de alimentos variaron entre 0.35-0.84 y para nutrimentos entre 0.36-0.77. La mayoría de sujetos (56.7-76.3%) clasificaron en el mismo quintil o adyacente por ambos métodos (media 66.1%), para nutrimentos. La mala clasificación extrema para todos los ítems fue.

  15. [Proposal of reference values of microbiological environment monitoring in foodservice establishments].

    PubMed

    Soler Quiles, Carla; Mañes, Jordi; Savino, Angelo; Soriano, José M

    2015-04-01

    Introducción: Proponer una nueva referencia microbiológica ambiental en los servicios de restauración. Objetivo: El presente trabajo muestra la determinación y evaluación de la contaminación microbiológica generada en un establecimiento de servicio de alimentos. Método: Se basa en el muestreo microbiológico de superficie utilizando filtros de membrana de ésteres mixtos de celulosa y en el muestreo de aire utilizando placas de Petri. Resultados: Los límites de contaminación se establecieron antes y durante la elaboración de alimentos, mediante el análisis microbiológico de las superficies y del medio ambiente, sistemas de equipos, hasta límites confiables y estableciendo niveles de aceptación en cada punto seleccionado. Por último, se estableció un programa de vigilancia microbiológica del medio ambiente incluyendo la evaluación de todos los parámetros que la componen y están implícitos en la zona, asegurando de esta manera y el apoyo a su continuidad con la documentación y los registros desarrollados para el área de seguridad. Las muestras para el análisis microbiológico se recogieron durante un período durante diez días diferentes, en dos horas diferentes. Se identificaron doce puntos como peligrosos. Además, los alimentos clasificados como de alto riesgo fueron recogidos periódicamente para el análisis microbiológico. Conclusiones: La posibilidad de utilizar de una amplia gama de medios selectivos, muy por encima del número limitado utilizado en este estudio, permite el análisis de muchas especies microbianas individuales.

  16. A strategy for weight loss based on healthy dietary habits and control of emotional response to food.

    PubMed

    Pontes Torrado, Yolanda; García-Villaraco Velasco, Ana; Hernández Galiot, Ana; Goñi Cambrodón, Isabel

    2015-06-01

    Introducción: el sedentarismo y los hábitos alimentarios poco saludables son las principales causas de un balance energético negativo y un exceso de peso corporal. El estilo de vida del patrón de dieta mediterránea reduce significativamente los factores de riesgo de enfermedades no transmisibles. Por otra parte, las emociones tienen un poderoso efecto en el comportamiento alimentario. Existe una relación directa entre la elección de alimentos, las emociones y el aumento de la ingesta energética. Objetivo: conocer el comportamiento emocional de los individuos para facilitar el establecimiento de pautas dietéticas personalizadas basadas en hábitos alimentarios saludables y aumentar la fidelidad del paciente hasta conseguir el peso deseado. Material y métodos: 99 personas adultas con sobrepeso fueron sometidos a un programa de reducción de peso basado en establecer unos hábitos alimentarios y un estilo de vida saludables. La adhesión al patrón de dieta Mediterránea y el efecto de las emociones en la elección de alimentos se determinaron utilizando los cuestionarios MEDAS (Mediterranean Diet Adherence Screener) y EEQ (Emocional Eater Questionnaire), respectivamente. Resultados: la población estudiada era sedentaria, consumía una dieta poco saludable y su conducta alimentaria era dependiente de las emociones. La mayoría de los participantes (66% mujeres y 71% hombres) fueron clasificados como comedores emocionales. Durante el programa de tratamiento, los participantes modificaron sus hábitos alimentarios y su estilo de vida, consiguiendo reducir el peso corporal en al menos un 10% respecto al peso inicial. Conclusión: conocer la relación entre la ingesta de alimentos y las emociones permite personalizar la estrategia dietética para disminuir el peso corporal y la tasa de abandono.

  17. [Not Available].

    PubMed

    Vio, Fernando; Lera, Lydia; Salinas, Judith

    2016-07-19

    Objetivo: mediante la técnica de consenso Delphi, conocer la opinión de un grupo de expertos en nutrición, educación y gastronomía para buscar consenso sobre metodologías educativas en alimentación saludable, alumnos de tercero a quinto año básico, sus familias y profesores.Métodos: con los resultados de encuestas y grupos focales realizados previamente a niños, padres y profesores, se elaboró un cuestionario que fue enviado a 51 expertos en nutrición, educación y gastronomía en una primera ronda. Los resultados fueron analizados y reenviados en una segunda ronda con las preguntas no consensuadas, obteniendo 38 respuestas.Resultados: hubo consenso en que se pueden cambiar hábitos en escuelas mediante talleres de cocina con chefs o monitores, educación activo-participativa y huertos escolares. Padres y profesores deben tener habilidades culinarias saludables para educar a los niños. Estos deben hacer uso racional del dinero en la escuela. Para ello es necesario cambiar la oferta del kiosko hacia alimentos saludables, o suprimirlo si no es saludable. Los profesores deben capacitarse con talleres de autocuidado y vida sana para educar en alimentación saludable a los niños en horarios de clase con material educativo, talleres de cocina con recetas y aprovechar horarios de desayuno y almuerzo para actividades educativas. Los padres deben participar en talleres para escoger alimentos saludables en lugares de venta y preparar menús saludables. Los niños deben aprender habilidades culinarias simples, preparando y degustando alimentos saludables. Conclusiones: estos resultados son fundamentales para diseñar materiales educativos en alimentación saludable que cambien los malos hábitos alimentarios actuales.

  18. Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis.

    PubMed

    Xue, Yongbo; Li, Xifeng; Du, Xue; Li, Xiaonian; Wang, Weiguang; Yang, Jianhong; Chen, Jijun; Pu, Jianxin; Sun, Handong

    2015-08-01

    Seven lignans with a dibenzocyclooctadiene skeleton, termed schinlignans A-G, and a 6,7-seco-homolignan, schischinone, together with seven known lignans, were isolated from the fruits of Schisandra chinensis (Turcz.) Baill. Their structures were elucidated by extensive spectroscopic methods, including HRESIMS, IR, UV, and 2D NMR (COSY, HMQC, COSY, and HMBC experiments). The stereochemistry at the chiral centers and the biphenyl moiety, were determined using ROESY, as well as via interpretation of their ECD spectra. Schinlignan G and methylgomisin O exhibited potent anti-hepatitis B virus activity against HBV DNA replication with IC50 values of 5.13 and 5.49μgmL(-1), respectively.

  19. Low-Level Waste Forum notes and summary reports for 1994. Volume 9, Number 3, May-June 1994

    SciTech Connect

    1994-06-01

    This issue includes the following articles: Vermont ratifies Texas compact; Pennsylvania study on rates of decay for classes of low-level radioactive waste; South Carolina legislature adjourns without extending access to Barnwell for out-of-region generators; Southeast Compact Commission authorizes payments for facility development, also votes on petitions, access contracts; storage of low-level radioactive waste at Rancho Seco removed from consideration; plutonium estimates for Ward Valley, California; judgment issued in Ward Valley lawsuits; Central Midwest Commission questions court`s jurisdiction over surcharge rebates litigation; Supreme Court decides commerce clause case involving solid waste; parties voluntarily dismiss Envirocare case; appellate court affirms dismissal of suit against Central Commission; LLW Forum mixed waste working group meets; US EPA Office of Radiation and Indoor Air rulemakings; EPA issues draft radiation site cleanup regulation; EPA extends mixed waste enforcement moratorium; and NRC denies petition to amend low-level radioactive waste classification regulations.

  20. Fimbriatols A-J, Highly Oxidized ent-Kaurane Diterpenoids from Traditional Chinese Plant Flickingeria fimbriata (B1.) Hawkes.

    PubMed

    Ding, Gang; Fei, Jiaodong; Wang, Jing; Xie, Yong; Li, Rongtao; Gong, Ningbo; Lv, Yang; Yu, Changyuan; Zou, Zhongmei

    2016-01-01

    Fimbriatols A-J (1-10), ten new ent-kaurane diterpenoids possessing differently highly oxidized sites, were isolated from Flickingeria fimbriata (B1.) Hawkes. The structures of these new compounds were determined by HRESI-MS, NMR, CD spectra and X-ray diffraction analysis. Compound 1 displayed moderately inhibitory ratio (48.5%) compared with the positive compound NSC-87877 (81.6%) at the concentration of 0.022 μg/mL. Compounds 7-10 possess 3, 4-seco-ent-kaurane skeleton containing a disaccharide moiety with an unusual linkage at C-2' to C-1'' instead of the common linkage at C-6' to C-1'', and this is the first report in 600 more ent-kauranes found in nature, which might be originated from ent-kaurane diterpenoids through post-modified reactions of Baeyer-Villiger oxygenation and glycosylation. PMID:27484744

  1. Spent nuclear fuel and residential property values : the influence of proximity, visual cues and public information.

    SciTech Connect

    Clark, D. E.; Allison, T.; Decision and Information Sciences; Marquette Univ.

    1999-10-01

    This article examines whether public knowledge of spent fuel storage at nuclear power plants, and any local adverse risk perceptions that may have occurred, affect the sale price of single-family residential properties. We present evidence from the Rancho Seco, California, plant on residential property values using an hedonic modeling framework. We include a large number of control variables, data with a high level of spatial detail and a number of public information variables in order to model property market effects within a fifteen mile radius of the plant. Our findings indicate that proximity and visual reminders of the plant have some influence on local property markets, and that there is a small media coverage effect on single-family home sale prices.

  2. Livermore Big Trees Park Soil Survey

    SciTech Connect

    McConachie, W.A.; Failor, R.A.

    1995-01-01

    Lawrence Livermore National Laboratory (LLNL) will sample and analyze soil in the Big Trees Park area in Livermore, California, to determine if the initial level of plutonium (Pu) in a soil sample taken by the U.S. Environmental Protection Agency (EPA) in September 1993 can be confirmed. Nineteen samples will be collected and analyzed: 4 in the area where the initial EPA sample was taken, 2 in the nearby Arroyo Seco, 12 in scattered uncovered soil areas in the park and nearby school, and 1 from the sandbox of a nearby apartment complex. Two quality control (QC) samples (field duplicates of the preceding samples) win also be collected and analyzed. This document briefly describes the purpose behind the sampling, the sampling rationale, and the methodology.

  3. Transformation of epiandrosterone into 3-oxa-, 3-thia-, 3-selena-, and 3-aza-17-oxaandrostanes of the 5 alpha series based on beta-scission of alkoxyl radicals.

    PubMed

    Suginome, H; Wang, J B

    1990-08-01

    3 beta-Hydroxy-5 alpha-androstan-17-one was transformed into 17-oxa-5 alpha-androstan-3 beta-ol in five steps involving conversion of the 17-ketone via the corresponding lactol to its hypoiodite and thence a regioselective beta-scission under irradiation to give ring D seco iodoformate, from which the 17-oxasteroids were derived. Four bisheterosteroids 3,17-dioxa-5 alpha-androstane, 3-thia-17-oxa-5 alpha-androstane, 3-aza-17-oxa-5 alpha-androstane, and 3-selena-17-oxa-5 alpha-androstane) were synthesized from 17-oxa-5 alpha-androstan-3 beta-ol via 5, 8, 8, and 9 steps, respectively, involving a second regioselective beta-scission of an alkoxyl radical as the key step.

  4. Atmospheric release advisory capability pilot project at two nuclear power plants and associated state offices of emergency preparedness. Final report

    SciTech Connect

    Rosen, L.C.

    1983-01-01

    A project to demonstrate the feasibility of utilizing Atmospheric Release Advisory Capability (ARAC) limited service with commercial nuclear power plants and their associated state offices of emergency preparedness is discussed. Preliminary planning, installation and testing of the ARAC site facilities at Indian Point Nucler Power Station, New York State; at New York State Office of Emergency Preparedness, Albany, New York; at Rancho Seco Nuclear Generating Station, California; and at the State of California Office of Emergency Services, Sacramento, California, are summarized. ARAC participation in the Robert E. Ginna nuclear generating plant accident in New York on January 25, 1982, is discussed. The ARAC system is evaluated with emphasis on communications, the suite of models contained within the ARAC system, and the staff. The implications of this project in designing the next-generation ARAC system to service federal and state needs are assessed.

  5. Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.

    PubMed

    Narita, Koichi; Fukui, Yurie; Sano, Yui; Yamori, Takao; Ito, Akihiro; Yoshida, Minoru; Katoh, Tadashi

    2013-02-01

    The bicyclic depsipeptide histone deacetylase (HDAC) inhibitors spiruchostatins C and D were synthesized for the first time in a highly convergent and unified manner. The method features the amide coupling of a D-leucine-D-cysteine- or D-valine-D-cysteine-containing segment with a D-alanine- or D-valine-containing segment to directly assemble the corresponding seco-acids, key precursors of macrolactonization. The HDAC inhibitory assay and cell-growth inhibition analysis of the synthesized depsipeptides determined the order of potency of spiruchostatins A-D in comparison with the clinically approved depsipeptide FK228 (romidepsin). Novel aspects of structure-activity relationships (SAR) were revealed. PMID:23313638

  6. Diversity-Oriented Synthesis Approach to Macrocycles via Oxidative Ring Expansion

    PubMed Central

    Kopp, Felix; Stratton, Christopher F.; Akella, Lakshmi B.

    2012-01-01

    Macrocycles are key structural elements in numerous bioactive small molecules and are attractive targets in the diversity-oriented synthesis of natural product-based libraries. However, efficient and systematic access to diverse collections of macrocycles has proven difficult using classical macrocyclization reactions. To address this problem, we have developed a concise, modular approach to the diversity-oriented synthesis of macrolactones and macrolactams involving oxidative cleavage of a bridging double bond in polycyclic enol ethers and enamines. These substrates are assembled in only 4–5 synthetic steps and undergo ring expansion to afford highly functionalized macrocycles bearing handles for further diversification. In contrast to macrocyclization reactions of corresponding seco-acids, the ring expansion reactions are efficient and insensitive to ring size and stereochemistry, overcoming key limitations of conventional approaches to systematic macrocycle synthesis. Cheminformatic analysis indicates that these macrocycles access regions of chemical space that overlap with natural products, distinct from currently-targeted synthetic drugs. PMID:22406518

  7. Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare.

    PubMed

    Chen, Chunmei; Wang, Jianping; Liu, Junjun; Zhu, Hucheng; Sun, Bin; Wang, Jing; Zhang, Jinwen; Luo, Zengwei; Yao, Guangmin; Xue, Yongbo; Zhang, Yonghui

    2015-06-26

    Ten new cytochalasan alkaloids, termed armochaetoglobins A-J (1-10), and four known chaetoglobosins (11-14) were isolated from a methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated by a combination of spectroscopy, single-crystal X-ray crystallography, and ECD calculations. Armochaetoglobins A-E (1-5) represented the first examples of seco-chaetoglobosins arising from an oxidative cleavage of C-19 and C-20. Among these compounds, armochaetoglobin A (1) features an unusual pyrrole ring. The cytotoxic activities of 2-10 were evaluated, and armochaetoglobin H (8) showed moderate inhibitory activities against five human cancer cell lines, with IC50 values ranging from 3.31 to 9.83 μM. PMID:26068802

  8. Terpenes with antimicrobial activity from Cretan propolis.

    PubMed

    Popova, Milena P; Chinou, Ioanna B; Marekov, Ilko N; Bankova, Vassya S

    2009-07-01

    Five terpenes, the diterpenes: 14,15-dinor-13-oxo-8(17)-labden-19-oic acid and a mixture of labda-8(17),13E-dien-19-carboxy-15-yl oleate and palmitate as well as the triterpenes, 3,4-seco-cycloart-12-hydroxy-4(28),24-dien-3-oic acid and cycloart-3,7-dihydroxy-24-en-28-oic acid were isolated from Cretan propolis. Moreover, 18 known compounds were also isolated, seven of them for the first time as propolis components. All structures were established on the basis of spectroscopic analysis and chemical evidence. All isolated compounds were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria as well as against some human pathogenic fungi showing a broad spectrum of antimicrobial activity.

  9. Triterpenoids from the roots of Rubus parvifolius.

    PubMed

    Zhang, Xu; Zhu, Zhi-Xiang; Wang, Juan; Yang, Wan-Qing; Su, Cong; Li, Jun; Zhang, Yuan; Zheng, Jiao; Shi, She-Po; Tu, Peng-Fei

    2016-05-01

    Two new oleanane-type triterpenoids, parvifolactone A (1) and rubuside P (2), together with 11 known triterpenoids, fupenzic acid (3), 18,19-seco,2α,3α-dihydroxyl-19-oxo-urs-11,13(18)-dien-28-oic acid (4), euscaphic acid (5), maslinic acid (6), 1β- hydroxyeuscaphic acid (7), 2α,3α,19α,23-tetrahydroxyolean-12-en-28-oic acid (8), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid (9), glucosyl pinfaensate (10), rubuside J (11), 2α,3α,19α,23-tetrahydroxyurs-12-en-24,28-dioic acid (12), and 2α,3β,19α- trihydroxyurs-12-en-23,28-dioic acid (13), were isolated from the roots of Rubus parvifolius. PMID:27478101

  10. Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya.

    PubMed

    Lin, Ching-Jie; Lo, I-Wen; Lin, Yu-Chi; Chen, Shun-Ying; Chien, Ching-Te; Kuo, Yao-Haur; Hwang, Tsong-Long; Liou, Shorong-Shii; Shen, Ya-Ching

    2016-01-01

    Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1-4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB). PMID:27598114

  11. Fimbriatols A–J, Highly Oxidized ent-Kaurane Diterpenoids from Traditional Chinese Plant Flickingeria fimbriata (B1.) Hawkes

    PubMed Central

    Ding, Gang; Fei, Jiaodong; Wang, Jing; Xie, Yong; Li, Rongtao; Gong, Ningbo; Lv, Yang; Yu, Changyuan; Zou, Zhongmei

    2016-01-01

    Fimbriatols A–J (1–10), ten new ent-kaurane diterpenoids possessing differently highly oxidized sites, were isolated from Flickingeria fimbriata (B1.) Hawkes. The structures of these new compounds were determined by HRESI-MS, NMR, CD spectra and X-ray diffraction analysis. Compound 1 displayed moderately inhibitory ratio (48.5%) compared with the positive compound NSC-87877 (81.6%) at the concentration of 0.022 μg/mL. Compounds 7–10 possess 3, 4-seco-ent-kaurane skeleton containing a disaccharide moiety with an unusual linkage at C-2′ to C-1′′ instead of the common linkage at C-6′ to C-1′′, and this is the first report in 600 more ent-kauranes found in nature, which might be originated from ent-kaurane diterpenoids through post-modified reactions of Baeyer-Villiger oxygenation and glycosylation. PMID:27484744

  12. Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata.

    PubMed

    Fu, Shao-bin; Yang, Jun-shan; Cui, Jin-long; Meng, Qing-feng; Feng, Xu; Sun, Di-An

    2011-10-01

    The structural modification of ursolic acid by an endophytic fungus Pestalotiopsis microspora, isolated from medicinal plant Huperzia serrata was reported for the first time. The structure diversity was very important for the SAR study of ursolic acid and its derivatives. Incubation of ursolic acid 1 with P. microspora afforded four metabolites: 3-oxo-15α, 30-dihydroxy-urs-12-en-28-oic acid (2), 3β, 15α-dihydroxy-urs-12-en-28-oic acid (3), 3β, 15α, 30- trihydroxy-urs-12-en-28-oic acid (4) and 3,4-seco-ursan-4,30-dihydroxy-12-en-3,28-dioic acid (5). All products were new compounds and their structures elucidation was mainly based on the spectroscopic data.

  13. An Algorithm to Estimate Field Concentrations in the Wake of a Power Plant Complex under Nonsteady Meteorological Conditions from Wind-Tunnel Experiments.

    NASA Astrophysics Data System (ADS)

    Kothari, K. M.; Meroney, R. N.; Bouwmeester, R. J. B.

    1981-08-01

    Highest concentrations of pollutant at ground level are often produced from surface sources with stable or unstable atmospheric conditions and near calm erratic winds. This paper describes a weighted data methodology developed to predict surface concentrations from stationary wind-tunnel measurements and actual meteorological wind fields. Field measurements made downwind of the Rancho Seco Nuclear Power Station in 1975 have been compared against a set of wind-tunnel measurements around a 1:500 scale model of the same facilities. The weighted data algorithm was realistic in both predicting centerline concentration values as well as the horizontal spread of the plume. On the average the wind-tunnel data combined with the weighting algorithm was some 40 times more accurate in predicting field data than the conventional Pasquill-Gifford formulas.

  14. Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig

    PubMed Central

    Zhou, Zhen-Fang; Kurtán, Tibor; Mándi, Attila; Gu, Yu-Cheng; Yao, Li-Gong; Xin, Guo-Rong; Li, Xu-Wen; Guo, Yue-Wei

    2016-01-01

    Eight new tetranortriterpenoids (1–8) were isolated from the twigs and leaves of the Chinese mangrove plant Xylocarpus granatum, together with four related known ones (9–12). The structures of new compounds were elucidated by detailed spectroscopic analysis. The absolute configuration of 9-epixylogranatin A (1) was determined by time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations of the solution conformers. Xylogranatumin A (2) represents the first example of the 9, 10-seco limonoid with an unprecedented oxygen-bridged B ring (2,7-dioxabicyclo[2.2.1]-heptane). All the isolates were evaluated for the in vitro neuroprotective activity, both compounds 11 and 12 displayed moderate effects against H2O2-induced neurotoxicity in PC12 cells at the concentration of 10 μM, with an increase in cell viability of 12.0% and 11.6%, respectively. PMID:27658619

  15. Isolation, Characterization, and Antiproliferative Activities of Eudesmanolide Derivatives from the Flowers of Inula japonica.

    PubMed

    Xie, Chunfeng; Wang, Hao; Sun, Xiaocong; Meng, Linghao; Wang, Meicheng; Bartlam, Mark; Guo, Yuanqiang

    2015-10-21

    Inula japonica belongs to the family Asteraceae, and its flowers have been used as dietary supplements and health tea in China. The study aimed to identify the bioactive components with the antiproliferative property. Ten 1,10-seco-eudesmanolide derivatives, including four new compounds (1-4), were isolated from the flowers of I. japonica. Their structures were established on the basis of the interpretation of spectroscopic data and electronic circular dichroism (ECD) calculations. All of these isolates were evaluated for their antiproliferative activities against MCF-7 and MDA-MB-231 human breast cancer cells. Compound 4 possessed the most potent effects, with the IC50 values of 0.20 ± 0.04 and 6.22 ± 1.30 μM against MCF-7 and MDA-MB-231 cells, respectively. The present investigation indicated that eudesmanolide derivatives from the flowers of I. japonica, especially compound 4, might be used as potential antitumor chemotherapy agent candidates.

  16. Complete 1H and 13C NMR assignments of three new polyhydroxylated sterols from the South China Sea gorgonian Subergorgia suberosa.

    PubMed

    Qi, Shu-Hua; Zhang, Si; Wang, Yi-Fei; Li, Ming-Yi

    2007-12-01

    Three new polyhydroxylated sterols, 3beta,6alpha,11,20beta,24-pentahydroxy- 9,11-seco-5alpha-24-ethylcholest-7,28-diene-9-one (1), 3-(1',2'-ethandiol)-24- methylcholest-8(9),22E-diene-3beta,5alpha,6alpha,7alpha,11alpha-pentaol (2), 24-methylcholest-7,22 E-diene-3beta,5alpha,6beta,25-tetraol (3) together with five known sterols, were isolated from the EtOH/CH2Cl2 extract of the South China Sea gorgonian Subergorgia suberosa. The complete assignments of the 1H and 13C NMR chemical shifts for these new compounds were achieved by means of 1D and 2D NMR techniques, including HSQC, HMBC, 1H--1H COSY, and NOESY spectra.

  17. Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing

    PubMed Central

    Chandran, Anandhakumar; Syed, Junetha; Taylor, Rhys D.; Kashiwazaki, Gengo; Sato, Shinsuke; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

    2016-01-01

    Chemically engineered small molecules targeting specific genomic sequences play an important role in drug development research. Pyrrole-imidazole polyamides (PIPs) are a group of molecules that can bind to the DNA minor-groove and can be engineered to target specific sequences. Their biological effects rely primarily on their selective DNA binding. However, the binding mechanism of PIPs at the chromatinized genome level is poorly understood. Herein, we report a method using high-throughput sequencing to identify the DNA-alkylating sites of PIP-indole-seco-CBI conjugates. High-throughput sequencing analysis of conjugate 2 showed highly similar DNA-alkylating sites on synthetic oligos (histone-free DNA) and on human genomes (chromatinized DNA context). To our knowledge, this is the first report identifying alkylation sites across genomic DNA by alkylating PIP conjugates using high-throughput sequencing. PMID:27098039

  18. [Issues regarding the legal regulation of drugs in Argentina].

    PubMed

    Bignone, Inés M

    2006-01-01

    This work describes the main functions and attributions of the National Administration of Medicines, Food and Medical Technology (Administración Nacional de Medicamentos, Alimentos y Tecnología Médica, ANMAT) of Argentina in the control and supervision of pharmaceutical products. The four properties that a medicine must full-fill (efficacy, safety, quality and accessibility) are described, and the role of ANMAT with regard to each one is specified. Criteria employed in the classification of pharmaceutical products marketed in Argentina with the regulatory agency permission are specified, and a reference to pharmaceutical products not registered before the Agency is also included.

  19. [Not Available].

    PubMed

    Vergara, Diego; Ríos-Reina, Rocío; Úbeda, Cristina; Escudero-Gilete, M Luisa; Callejón, Raquel M

    2016-01-01

    Introducción: en la actualidad existe un déficit en la evaluación de comedores dirigidos a niños menores de 3 años, a pesar de que se han realizado numerosas intervenciones en los comedores escolares con el fin de conseguir una alimentación segura y adecuada.Objetivo: realizar una evaluación nutricional de los menús ofertados en los centros de educación infantil de Sevilla.Material y métodos: se evaluó la frecuencia, variedad, rotación de alimentos, métodos culinarios e información de los menús de seis centros infantiles de Sevilla. Se valoró el aporte energético y nutricional mediante el programa Dietowin® y el método de pesada.Resultados: las frutas y verduras fueron deficitarias en la mayoría de los menús, y excesivas la carne, patatas, pasta y arroz. Se observó una escasa variedad de recetas por grupo de alimentos y no se daba una información completa del menú. Sin embargo, la variedad de procesos culinarios y la rotación de alimentos fueron adecuadas. Aunque la energía y el aporte de carbohidratos (~55%) se ajustaban a las necesidades, se observó un aporte excesivo de proteínas (~19%) y deficiente de lípidos (< 30%), sobre todo de grasas insaturadas. Respecto a los micronutrientes,solo vitamina C, E y calcio estaban por debajo de lo recomendado.Conclusiones: los centros de educación infantil están haciendo un gran esfuerzo por cumplir las recomendaciones nutricionales, pero todavía deben disminuir el aporte proteico y aumentar las grasas insaturadas de la dieta. Además, deben fomentar la oferta de frutas y verduras, ampliar la variedad de recetas, dar mayor información y disminuir el aporte de alimentos cárnicos. PMID:27513504

  20. ACCEPTANCE OF FUNCTIONAL FOOD AMONG CHILEAN CONSUMERS: APPLE LEATHER.

    PubMed

    van Vliet, Maya; Adasme-Berrios, Cristian; Schnettler, Berta

    2015-10-01

    Objetivo: el objetivo de este estudio es medir la aceptación de un alimento funcional como la lámina frutal de manzana, en base a características organolépticas. Se identificaron tipos de consumidores y sus preferencias hacia los aditivos naturales que aumentan la funcionalidad del producto y satisfacen las necesidades nutricionales actuales. Materiales y método: una muestra de 800 consumidores permitió la evaluación de la lámina frutal de manzana en términos de aceptación (gusto). se llevó a cabo un panel sensorial utilizando una escala hedónica de nueve puntos. Se utilizó el análisis de conglomerados para establecer diferentes tipos de consumidores, basados en la aceptación del producto. Además, el análisis conjunto permitió determinar la preferencia sobre diferentes aditivos. Resultados: el análisis de conglomerados permitió identificar cuatro grupos con diferencias significativas en los gustos promedios, obtenidos del panel sensorial. Los resultados indican que el dulzor de la lámina frutal de manzana fue mejor evaluada entre todos los grupos y, en promedio, el color fue calificado como el peor atributo. Además, a pesar de que existe una “aceptabilidad global” por el producto, existen diferencias significativas entre los grupos. Los resultados del análisis conjunto indican que, en general, los consumidores prefieren la agregación de aditivos naturales que aumentan la funcionalidad del producto. Conclusiones: en este estudio, la lámina frutal de manzana como alimento funcional se ajusta con el hábito de las personas de consumir alimentos dulces, lo que promueve su aceptación. Además, la agregación de aditivos naturales al producto, tales como anticariogénicos y antioxidantes, permite considerarlo como un alimento funcional sustituto de los snacks, poco saludables y/o de los caramelos.

  1. Como Lo Hago Yo: Defectos Del Cierre Del Tubo Neural En Nicaragua

    PubMed Central

    Gonzalez, Juan Bosco

    2014-01-01

    En Nicaragua no hay un plan de forltificación de alimentos con ácido fólico. Las madres son muy jóvenes. En La Mascota operamos mas de cuarenta niños por año. Derivación tardía es un problema. La infección preoperatoria tiene que ser descartada. Vancomicina y Ceftriaxone estan indicadas. Estricta regla de asepsia operatoria. Suturamos la plaqueta para asemejar su forma al cilindro normal de la médula. No ceramos la capa de músculo. PMID:24791221

  2. Dietary intake and nutritional status in cancer patients; comparing adults and older adults.

    PubMed

    Gómez Valiente da Silva, Henyse; Fonseca de Andrade, Camila; Bello Moreira, Annie Seixas

    2014-04-01

    Objetivo: Evaluar la ingesta de nutrientes y el estado nutricional de los alimentos en pacientes con cáncer ingresados en un hospital universitario, comparando por categoría de edad entre adulto y adulto mayor. Métodos: Estudio transversal. Este estudio incluía pacientes cancerosos ingresados en un hospital en 2010. Se recogieron los hábitos dietéticos mediante un cuestionario brasileño de frecuencia de alimentos. Se dividieron los participantes en dos grupos: adultos y adultos mayores y en 4 categorías de cáncer: hematológico, pulmonar, gastrointestinal y otros. El estado nutricional se evaluó con el índice de masa corporal. Resultados: Se evaluó a un total de 86 pacientes con una edad promedio de 56,5 años, siendo el 55 % varones y el 42 % adultos mayores. La categoría de adultos mayores tenía con mayor frecuencia peso bajo (24,4 % frente a 16,3 %, p < 0,01) y una menor frecuencia de sobrepeso (7 % frente a 15,1 %, p < 0,01) que los adultos. En ambos grupos había una frecuencia elevada de fumadores, consumo de alcohol e inactividad física. Los adultos mayores tenían un menor consumo de calorías, ingesta de hierro y ácido fólico. Se observó una ingesta inadecuada de vitaminas en ambos grupos; respectivamente, 52 %, 43 %, 95 %, 76 % y 88 % para las vitaminas A, C, D, E y el ácido fólico. Los adultos mayores tenían más ingesta inadecuada de ácido fólico y calcio que los adultos (97 % frente a 82 %, p < 0,01; 88 % frente a 72 %, p < 0,01). No hubo una asociación entre la ingesta de micronutrientes con el cáncer ni con el estado nutritivo. Conclusión: La ingesta de alimentos y de macro y micronutrientes es insuficiente en los individuos con cáncer. La ingesta de alimentos en adultos mayores fue menor en comparación con los adultos. Hubo una prevalencia elevada de IMC excesivo en el grupo de adultos y un peor estado nutricional en la categoría de adultos mayores.

  3. GASTRIC CANCER AND ASSOCIATED FACTORS IN HOSPITALIZED PATIENTS.

    PubMed

    Galvão de Azevedo, Ioná; Leal Muniz Carneiro, Izabel Cristina; Oliveira Tomiya, Marília Tokiko; Pessoa de Araújo Burgos, Maria Goretti

    2015-07-01

    Introducción: a pesar de la disminución de la incidencia y la mortalidad, el cáncer gástrico sigue siendo el cuarto tumor más frecuente y la segunda causa de muerte por cáncer en el mundo. Objetivos: analizar los factores asociados con el cáncer gástrico en pacientes hospitalizados. Método: estudio de corte serie de casos, realizado en hospitales de Recife. Los datos fueron obtenidos a partir de cuestionarios adaptados de un modelo previamente validado, que contenían los problemas socioeconómicos, los hábitos alimentarios, el estilo de vida, los antecedentes familiares de cáncer, la infección por H. pylori y los datos antropométricos. Resultados: de los 33 pacientes, tuvieron un ligero predominio las mujeres con edades ≥ 60 años, de zonas rurales, con bajos niveles de educación e ingresos. De acuerdo con el IMC, el 57,6% fueron normales y el 69,7% en riesgo nutricional cuando se utiliza% PP. Se encontró que el 42,4% no se sometió a examen para H. pylori, el 48,5% tenían una predisposición genética, el 75,8% eran sedentarios, el 60,6% eran fumadores y ex fumadores, el 51,5% eran adictos al alcohol y el 36,4% tenían sobrepeso. Hubo consumo frecuente de alimentos salados, alimentos fritos, baja ingesta de frutas, alimentos que contienen nitratos/ nitritos, así como una inadecuada conservación de los alimentos. Conclusión: el bajo nivel socioeconómico, la inactividad física y los hábitos alimentarios inadecuados fueron factores predominantes para el cáncer gástrico en el grupo analizado.

  4. [Profile of sensitization to allergens in children with atopic dermatitis assisting to Allergology Service of University Hospital, Nuevo Leon, Mexico].

    PubMed

    Yong-Rodríguez, Adrián; Macías-Weinmann, Alejandra; Palma-Gómez, Samuel; Arias-Cruz, Alfredo; Pérez-Vanzzini, Rafael; Gutiérrez-Mujica, José Julio; González-Díaz, Sandra Nora

    2015-01-01

    Antecedentes: la sensibilización a alergenos observada en la dermatitis atópica aumenta el riesgo del niño a padecer rinitis alérgica y asma. Los estudios recientes indican que entre mayor actividad de proteasas haya en los alergenos a los que se está sensibilizado, hay mayor defecto en la barrera cutánea y mayor gravedad de la enfermedad. Objetivos: conocer el patrón de sensibilización a los alergenos en niños con dermatitis atópica atendidos en el Servicio de Alergología del Hospital Universitario de la Universidad Autónoma de Nuevo León y conocer si estos niños tienen mayor sensibilización a los antígenos con actividad proteolítica. Material y método: estudio retrospectivo en el que revisamos los reportes de las pruebas cutáneas por punción realizadas en nuestro servicio a niños de 5 meses a 16 años de edad, con diagnóstico de dermatitis atópica, de enero de 2012 a enero de 2014. Evaluamos la frecuencia de sensibilización a aeroalergenos y alimentos, así como el tamaño de la roncha en la respuesta cutánea para cada alergeno en particular. Resultados: se incluyeron los reportes de pruebas cutáneas de 66 niños, 30 hombres y 36 mujeres. Cuarenta y seis pacientes estaban sensibilizados a aeroalergenos y 38 a alimentos. Los ácaros del polvo de casa (Dermatophagoides pteronyssinus/Dermatophagoides farinae) fueron los alergenos con mayor frecuencia de respuesta positiva en las pruebas cutáneas. De los niños con sensibilización a alimentos, sólo los niños sensibilizados a la leche de vaca, al huevo y al pescado tuvieron una roncha mayor de 6 mm de diámetro. CONCLUSIÓN: en los niños con dermatitis atópica es común la sensibilización a aeroalergenos con alta actividad de proteasas y la polisensibilización es muy común. La sensibilización a alimentos es común en estos pacientes, pero sólo un pequeño porcentaje de ellos muestra respuestas cutáneas lo suficientemente grandes para relacionarlas con gravedad de la enfermedad.

  5. FOOD CONSUMPTION PATTERNS DURING PREGNANCY: A LONGITUDINAL STUDY IN A REGION OF THE NORTH EAST OF BRAZIL.

    PubMed

    Da Mota Santana, Jerusa; Alves de Oliveira Queiroz, Valterlinda; Monteiro Brito, Sheila; Barbosa Dos Santos, Djanilson; Marlucia Oliveira Assis, Ana

    2015-07-01

    Introducción: las perspectivas de crecimiento en Brasil indican que los patrones dietéticos de la población se caracterizan por el aumento del consumo de grasas saturadas y trans, sodio, azúcares y refrescos. Este punto de vista epidemiológico y nutricional refleja el cambio en el patrón de la enfermedad y la muerte. Objetivo: este estudio tiene como objetivo identificar los patrones de consumo de alimentos y los cambios en la dieta en el primer y tercer trimestres del embarazo. Metodología: se trata de un estudio de cohorte prospectivo de 185 mujeres embarazadas del Estado de Bahía, a partir de 2012 a 2013. Se utilizó el cuestionario de frecuencia de alimentos para evaluar la ingesta alimentaria. Para identificar la norma alimentaria se adoptó el análisis factorial de componentes principales. Se utilizó la prueba de correlación de Pearson para identificar la correlación entre los patrones extraídos en cada trimestre. Resultados: se identificaron cuatro patrones de consumo de alimentos durante el embarazo. Hemos observado cambios en los patrones de alimentación durante los trimestres evaluados, especialmente para los grupos de frutas, café, grasas, frituras, azúcar y dulces. Discusión: estos cambios en la dieta durante el embarazo acompañan a los cambios fisiológicos de cada embarazo. En el primer trimestre son síntomas comunes las náuseas y los vómitos; por otro lado, también se manifiesta antojos en el mismo periodo, lo cual puede justificar el consumo de mayor cantidad de alimentos considerados saludables. Conclusión: se observaron cambios en el patrón alimentario a lo largo de los diversos trimestres del embarazo examinados, especialmente para los grupos de frutas, café, grasas, frituras, azúcar y dulces.

  6. [Vitamin D intake in a representative sample of Spanish population aged 7-16 years. Differences in the contribution and in the food sources of the vitamin according to age].

    PubMed

    Aparicio Vizuete, Aránzazu; López-Sobaler, Ana María; López Plaza, Bricia; Perea Sánchez, José Miguel; Ortega Anta, Rosa M

    2013-01-01

    Introducción: La vitamina D juega un importante papel en el mantenimiento de la salud ósea y prevención de la aparición de diversas enfermedades. Muy pocos alimentos son fuente natural de esta vitamina y, además, éstos no se consumen de manera habitual, siendo las fuentes dietéticas más importantes el pescado azul y la yema del huevo. Objetivos: Analizar la ingesta y las fuentes de vitamina D en escolares de 7-16 años. Métodos: Se estudió una muestra representativa de la población española de 7 a 16 años (n = 1.976), seleccionada en diez provincias españolas. El estudio dietético se realizó por registro del consumo de alimentos durante 3 días. Los parámetros antropométricos estudiados fueron el peso y la talla. Resultados y discusión: La ingesta media de vitamina D (1,63 (0,96-3,35) μg/día) fue inferior a la recomendada (IR) en un 85,4% de los estudiados, estando influenciada por la edad (OR = 0,935; IC: 0,889-0,983; p < 0,01). La principal fuente de vitamina D fueron los huevos (27,7%) seguidos de cereales (25,8%), pescados (20,9%) y lácteos (12,7%). Además, se ha observado que es más fácil cubrir las ingestas recomendadas de vitamina D cuanto mayor es el consumo de pescado (r = 0,734; p < 0,001), y que por cada ración que aumenta el consumo de este grupo de alimentos el riesgo de no cubrir las IR de vitamina D disminuye un 72,5%. Conclusiones: La ingesta de vitamina D es inferior a la recomendada en un elevado porcentaje de los estudiados. Teniendo en cuenta que los pescados juegan un importante papel en el aporte de vitamina D de los niños y adolescentes españoles, aumentar el consumo de este grupo de alimentos resulta deseable. Los niños de menor edad merecen atención especial.

  7. Review of complementary feeding practices in Mexican children.

    PubMed

    Pantoja-Mendoza, Itzayana Y; Meléndez, Guillermo; Guevara-Cruz, Martha; Serralde-Zúñiga, Aurora E

    2014-10-19

    Antecedentes: El inicio de la alimentación complementaria temprana coincide con un aumento significativo en la prevalencia de sobrepeso y obesidad especialmente en los niños, lo cual se debe entre otras causas a los cambios en los patrones de alimentación que se han experimentado. El objetivo del estudio fue describir las prácticas de alimentación complementaria en niños mexicanos. Métodos: Se realizó una búsqueda de los estudios que evaluaron las prácticas alimentarias en menores de 2 años en México en Medline, Lilacs y de forma manual con los siguientes términos: alimentación complementaria, alimentación suplementaria, México, ablactación y destete. Se recabó la edad de inicio de la alimentación complementaria, tipo de alimento consumido, frecuencia de consumo de los alimentos y motivo por el que iniciaban la alimentación complementaria. Se realizó un análisis cualitativo de la información recolectada y los datos en las gráficas son mostrados como proporciones. Resultados: Se incluyeron 7 estudios que mostraron que los niños inician la alimentación complementaria antes de los 6 meses predominantemente con frutas, aunque también consumieron jugos industrializados, refrescos y frituras. El consumo de estos productos aumenta con el crecimiento de los niños, aunado a un bajo consumo de alimentos con proteína de alto valor biológico, especialmente las carnes rojas. Conclusiones: Los resultados de los estudios incluidos mostraron que los menores reciben alimentos con alta densidad energética, mientras que es bajo el consumo de aquellos que aportan proteína animal y hierro en particular, lo que puede contribuir a problemas de salud como sobrepeso, obesidad, desnutrición y anemia.

  8. [Not Available].

    PubMed

    Vergara, Diego; Ríos-Reina, Rocío; Úbeda, Cristina; Escudero-Gilete, M Luisa; Callejón, Raquel M

    2016-06-30

    Introducción: en la actualidad existe un déficit en la evaluación de comedores dirigidos a niños menores de 3 años, a pesar de que se han realizado numerosas intervenciones en los comedores escolares con el fin de conseguir una alimentación segura y adecuada.Objetivo: realizar una evaluación nutricional de los menús ofertados en los centros de educación infantil de Sevilla.Material y métodos: se evaluó la frecuencia, variedad, rotación de alimentos, métodos culinarios e información de los menús de seis centros infantiles de Sevilla. Se valoró el aporte energético y nutricional mediante el programa Dietowin® y el método de pesada.Resultados: las frutas y verduras fueron deficitarias en la mayoría de los menús, y excesivas la carne, patatas, pasta y arroz. Se observó una escasa variedad de recetas por grupo de alimentos y no se daba una información completa del menú. Sin embargo, la variedad de procesos culinarios y la rotación de alimentos fueron adecuadas. Aunque la energía y el aporte de carbohidratos (~55%) se ajustaban a las necesidades, se observó un aporte excesivo de proteínas (~19%) y deficiente de lípidos (< 30%), sobre todo de grasas insaturadas. Respecto a los micronutrientes,solo vitamina C, E y calcio estaban por debajo de lo recomendado.Conclusiones: los centros de educación infantil están haciendo un gran esfuerzo por cumplir las recomendaciones nutricionales, pero todavía deben disminuir el aporte proteico y aumentar las grasas insaturadas de la dieta. Además, deben fomentar la oferta de frutas y verduras, ampliar la variedad de recetas, dar mayor información y disminuir el aporte de alimentos cárnicos.

  9. Food choices coping strategies of eating disorder patients' parents: what happens when both mother and father work?

    PubMed

    Jáuregui-Lobera, I; Ruiz-Prieto, I; Bolaños-Ríos, P; Garrido-Casals, O

    2013-11-01

    Objetivo: recientemente se ha comunicado que la elección de alimentos por parte de familiares de pacientes con trastornos alimentarios no es adecuada teniendo en cuenta un modelo saludable de hábitos de alimentación. El objetivo de este estudio fue analizar de que forma las condiciones de trabajo se relacionan con las estrategias de afrontamiento en la elección de alimentos tanto en familias con algún miembro que padece un trastorno alimentario como en otras sin miembros con estos trastornos También se analizaron las diferencias en el tipo de estrategias usadas por unas y otras familias. Métodos: Un total de 80 padres (n = 27) y madres (n = 53) de pacientes con trastornos alimentarios (n = 50), con trabajo extra-doméstico, e hijos sin alteraciones psicopatológicas (n = 30) fueron entrevistados. La edad media fue de 43.57 ± 5.69 años y los ingresos económicos fueron moderados. Las estrategias de afrontamiento en la elección de alimentos usadas para integrar vida laboral y familiar fueron evaluadas mediante 22 ítems incluidos en cinco categorías. Resultados: Los padres y madres de pacientes con trastornos alimentarios presentaron mejores estrategias que los de hijos sin patologías. El hecho de preparar más comidas en casa y usar menos comida rápida como comida principal son algunos ejemplos de esas mejores estrategias así como presentar menos pérdidas de desayunos y almuerzos debido al conflicto familia-trabajo, presentar menor picoteo y menor frecuencia de sobreingestas tras haber perdido alguna comida. Discusión: El esfuerzo terapéutico para mejorar la elección de alimentos en los padres de pacientes con trastornos alimentarios, especialmente cuando ambos trabajan fuera de casa, es un punto clave para mejorar los hábitos de alimentación de los pacientes contribuyendo ello a unos mejores resultados del tratamiento global.

  10. [Assessing food acceptance in scholar children; qualitative visual record versus food waste analysis].

    PubMed

    Rodriguez Tadeo, Alejandra; Patiño Villena, Begoña; Periago Castón, María Jesús; Ros Berruezo, Gaspar; González Martínez-Lacuesta, Eduardo

    2014-05-01

    Introducción: Los comedores escolares cuentan con normativa de gestión y supervisión de menús, sin embargo no se ha valorado si son consumidos en su totalidad. Objetivo: Valorar la aceptación de alimentos mediante pesado de restos y validación de una metodología visual para su estimación en comedores escolares de Murcia. Metodología: Participaron escolares de segundo y tercer ciclo de educación primaria, de 8-12 años. La estimación de restos se realizó mediante pesado de alimentos de 765 bandejas. La valoración visual (300 bandejas) se realizó con escala categórica: 1 = 0-25%; 2 = 26-50%; 3 = 51- 75% y 4 = 76-100%, por dos dietistas y se valoró la fiabilidad con respecto al pesado de alimentos. La concordancia entre ambos métodos fue evaluada en dos muestras estratificadas por la presencia/ausencia de cocina en la escuela. Resultados: Los primeros platos con más restos fueron pasta, arroz y purés de verduras siendo mayor en aquellos colegios sin cocina en el centro (p < 0,05). También los segundos platos a base de legumbres, ave y pescado y ensaladas de guarnición. Las frutas y el total de restos son superiores en colegios sin cocina (p < 0,05). La concordancia entre evaluadoras fue alta en platos a base de carnes y en ensaladas, y considerable en legumbres, precocinados, tortilla de huevo, pasta, pescado y arroz. Conclusiones: Los restos son elevados y existieron diferencias en la aceptación de ciertos alimentos acorde al tipo de menú ofertado. La escala visual es una herramienta confiable para medir la aceptación de forma indirecta, pero necesita capacitación y entrenamiento del personal implicado.

  11. [NUTRITIONAL STATUS AND BIOCHEMICAL MARKERS OF DEFICIENCY OR EXCESS OF MICRONUTRIENTS IN 4 TO 14 YEAR-OLD CHILEAN CHILDREN: A CRITICAL REVIEW].

    PubMed

    Rozowski Narkunska, Jaime; Castillo Valenzuela, Oscar; Figari Jullian, Nicole; García-Díaz, Diego F; Cruchet Muñoz, Sylvia; Weisstaub Nuta, Gerardo; Pérez-Bravo, Francisco; Gotteland Russel, Martín

    2015-12-01

    La prevalencia de obesidad en niños chilenos ha aumentado consistentemente en las últimas dos décadas. El primer estudio que determinó el estado nutricional y la ingesta de alimentos efectuado en una muestra representativa de la población fue llevado a cabo en 1960. Recientemente el Ministerio de Salud publicó la Encuesta Nacional de Consumo Alimentario (ENCA), efectuada en el año 2012. Sin embargo, este estudio no incluyó mediciones bioquímicas de nutrientes que permitan un diagnóstico integral y representativo de la condición nutricional del niño en Chile. Objetivos: revisar la literatura disponible entre los años 2004 y 2014 sobre ingesta de alimentos y estado nutricional en niños chilenos de 4 a 14 años de edad. Método: un total de 362 referencias publicadas en ese período se obtuvieron de las bases de datos PubMed, Lilacs, Embase y Scielo. De estos, 40 artículos fueron seleccionados para una revisión completa. Resultados: la ingesta de alimentos se caracteriza por una ingesta calórica alta; un bajo consumo de frutas, verduras y productos lácteos y un alto consumo de pan. La ENCA concluyó que un 95% de los chilenos presenta una dieta deficiente. Se observa una alta prevalencia de obesidad desde edades tempranas. Desde 1960 no ha habido un estudio representativo de la población que incluya niveles plasmáticos de micronutrientes, que proveerían información más confiable sobre el estado nutricional de los niños, además de encuestas de consumo de alimentos. Conclusión: los niños chilenos presentan un estado nutricional y una alimentación deficientes; sin embargo, no hay evidencia representativa de los niveles plasmáticos de nutrientes, por lo que es imperativo desarrollar un estudio representativo que incluya indicadores bioquímicos de micronutrientes con objeto de desarrollar estrategias para mejorar el estado nutricional de los niños.

  12. [Impact of a nutrition education intervention in teachers, preschool and basic school-age children in Valparaiso region in Chile].

    PubMed

    Vio, Fernando; Salinas, Judith; Montenegro, Edith; González, Carmen Gloria; Lera, Lydia

    2014-06-01

    Objetivo: Evaluar el efecto del programa educativo realizado en profesores, en el estado nutricional, conocimiento y consumo de alimentos saludables de alumnos de prekinder a segundo básico intervenidos y sus controles. Material y Método: Se trata de una intervención en educación nutricional en profesores de prebásica y básica, durante un año escolar, con una evaluación antes y después de sus alumnos, comparado con un grupo control. La muestra quedó constituida por 817 alumnos (389 hombres y 428 mujeres) de prekinder, kínder, 1º y 2º básico, 465 en los dos colegios intervenidos (Liceo 1 = 283 y Liceo 2 = 182) y 352 en el control. La intervención consistió en 9 talleres participativos y con uso de Tecnologías de la Información y Comunicación (TIC) a los profesores y en una evaluación de estado nutricional y encuesta de conocimiento y consumo de sus alumnos, al inicio y final del año académico. Resultados: En estado nutricional no se produjeron diferencias significativas entre el inicio y final de la intervención. En uno de los colegios intervenidos se observó una disminución significativa de la obesidad, en mujeres y en el grupo de 7 a 9 años. En los colegios intervenidos hubo una mejoría significativa en conocimiento y disminución en el consumo de alimentos poco saludables con respecto al control, en el cual se mantuvo la alimentación poco saludable y disminuyó el consumo de verduras y legumbres. Conclusiones: Al igual que en otros estudios, queda demostrado que una intervención educativa participativa, con uso de TIC y de corta duración en profesores y alumnos de prebásica y básica, puede producir cambios positivos en el estado nutricional, mejorando significativamente el conocimiento y consumo de alimentos saludables y disminuyendo el consumo de alimentos no saludables, lo que no sucede en el grupo control. Sin embargo, queda pendiente una estrategia de como implicar a los padres en esta tarea.

  13. Storm to Seasonal Nitrate Flushing and Relationship to Hydroclimatic Conditions

    NASA Astrophysics Data System (ADS)

    Barco, J.; Wessel, C.; Gunawan, S.; Hogue, T. S.

    2009-05-01

    Coupled hydrological and geochemical cycles have historically been used to understand the mechanisms controlling chemical export at the watershed scale. Numerous studies have focused on stream geochemistry dynamics and particularly on the effects of nitrogen deposition on catchments and ecosystems. However, few studies have evaluated the variability in nitrate behavior in watersheds with different climate and hydrologic characteristics. Furthermore, storm nitrate dynamics (flushing) and corresponding relationship to discharge patterns, precipitation intensity, atmospheric deposition, and watershed properties is an area with few published studies. In the current study, we utilize hydrologic, geochemical and atmospheric data to better understand the primary processes controlling nitrate dynamics at monthly and seasonal time scales in ten watersheds located in the U.S. Stream data (discharge and nitrate concentrations) was obtained from the United States Geological Survey (USGS). Atmospheric deposition data was gathered from regional National Atmospheric Deposition Program (NADP) sites. Collected data were assessed to evaluate nitrate dynamics for the period 2000-2006. Intra-storm nitrate variability was also evaluated in a watershed in Southern California (Arroyo Seco) where estimates of dry deposition are considered some of the highest in North America. Results from our analyses show that nitrate concentration appears to respond differently in the studied watersheds, exhibiting dilution effects in some watersheds and concentration effects in others. Discharge and nitrate concentrations during the 2009 winter reveal that the Arroyo Seco watershed is characterized by distinctive flushing of nitrates within storms. The role of specific hydrological events (size, intensity and duration) on the nitrate mobilization proved to be important as well as the accumulated nitrate pool available for mobilization. In general, results show a strong linkage between hydrological and

  14. Adaptation of microalgae to a gradient of continuous petroleum contamination.

    PubMed

    Carrera-Martinez, Daniel; Mateos-Sanz, Aranzazu; Lopez-Rodas, Victoria; Costas, Eduardo

    2011-01-25

    In order to study adaptation of microalgae to petroleum contamination, we have examined an environmental stress gradient by crude oil contamination in the Arroyo Minero River (AMR), Argentina. Underground crude oil has constantly leaked out since 1915 as a consequence of test drilling for possible petroleum exploitation. Numerous microalgae species proliferated in AMR upstream of the crude oil spill. In contrast, only four microalgal species were detected in the crude oil spill area. Species richness increases again downstream. Microalgae biomass in the crude oil spill area is dominated by a mesophile species, Scenedesmus sp. Effects of oil samples from AMR spill on photosynthetic performance and growth were studied using laboratory cultures of two Scenedesmus sp. strains. One strain (Se-co) was isolated from the crude oil spill area. The other strain (Se-pr) was isolated from a pristine area without petroleum contamination. Crude oil has undetectable effects on Se-co strain. In contrast crude oil rapidly destroys Se-pr strain. However, Se-pr strain can adapt to low doses of petroleum (≤ 3% v/v total hydrocarbons/water) by means of physiological acclimatization. In contrast, only rare crude oil-resistant mutants are able to grow under high levels of crude oil (≥ 10% v/v total hydrocarbons/water). These crude oil-resistant mutants have arisen through rare spontaneous mutations that occur prior to crude oil exposure. Species richness in different areas of AMR is closely connected to the kind of mechanism (genetic adaptation vs. physiological acclimatization) that allows adaptation. Resistant-mutants are enough to assure the survival of microalgal species under catastrophic crude oil spill.

  15. Ticks (Acari: Ixodidae) on wild birds in north-central Argentina.

    PubMed

    Flores, Fernando S; Nava, Santiago; Batallán, Gonzalo; Tauro, Laura B; Contigiani, Marta S; Diaz, Luis A; Guglielmone, Alberto A

    2014-10-01

    Ixodid ticks were collected from wild birds in five ecoregions in north-central Argentina, namely: Selva de las Yungas, Esteros del Iberá, Delta e Islas del Paraná, Selva Paranaense and Chaco Seco. A total of 2199 birds belonging to 139 species, 106 genera, 31 families and 11 orders were captured, but ticks were collected only from 121 birds (prevalence=5.5%) belonging to 39 species (28.1%) and three Orders: Tinamiformes (Tinamidae) and Falconiformes (Falconidae) in Selva de las Yungas and Passeriformes (Conopophagidae, Corvidae, Emberizidae, Furnariidae, Icteridae, Parulidae, Thamnophilidae, Thraupidae, Troglodytidae, Turdidae) for all ecoregions. The following tick species were found: Haemaphysalis juxtakochi, Haemaphysalis leporispalustris, Ixodes pararicinus plus Amblyomma sp. and Haemaphysalis sp. in Selva de las Yungas; Amblyomma triste and Ixodes auritulus in Delta e Islas del Paraná; Amblyomma dubitatum, A. triste and Amblyomma sp. in Esteros del Iberá; Amblyomma ovale and Amblyomma sp. in Selva Paranaense, and Amblyomma tigrinum in Chaco Seco. Amblyomma dubitatum was found for the first time on Passeriformes, while the records of A. ovale on avian hosts are the first for Argentina. Birds are also new hosts for I. pararicinus females. Besides 2 larvae and 1 nymph, and 1 larvae found on Tinamidae (Tinamiformes) and Falconidae (Falconiformes), respectively, all other ticks (691 larvae, 74 nymphs and 2 females) were found on Passeriformes with a relevant contribution of the family Turdidae. Birds are important hosts for I. pararicinus as shown by a prevalence of 45% while all others prevalence were below 15%. All the species of Amblyomma and Haemaphysalis found on birds in Argentina have been also detected on humans and are proven or potential vectors for human diseases. Therefore, their avian hosts are probable reservoirs of human pathogens in Argentina.

  16. Embedded wavelet-based face recognition under variable position

    NASA Astrophysics Data System (ADS)

    Cotret, Pascal; Chevobbe, Stéphane; Darouich, Mehdi

    2015-02-01

    For several years, face recognition has been a hot topic in the image processing field: this technique is applied in several domains such as CCTV, electronic devices delocking and so on. In this context, this work studies the efficiency of a wavelet-based face recognition method in terms of subject position robustness and performance on various systems. The use of wavelet transform has a limited impact on the position robustness of PCA-based face recognition. This work shows, for a well-known database (Yale face database B*), that subject position in a 3D space can vary up to 10% of the original ROI size without decreasing recognition rates. Face recognition is performed on approximation coefficients of the image wavelet transform: results are still satisfying after 3 levels of decomposition. Furthermore, face database size can be divided by a factor 64 (22K with K = 3). In the context of ultra-embedded vision systems, memory footprint is one of the key points to be addressed; that is the reason why compression techniques such as wavelet transform are interesting. Furthermore, it leads to a low-complexity face detection stage compliant with limited computation resources available on such systems. The approach described in this work is tested on three platforms from a standard x86-based computer towards nanocomputers such as RaspberryPi and SECO boards. For K = 3 and a database with 40 faces, the execution mean time for one frame is 0.64 ms on a x86-based computer, 9 ms on a SECO board and 26 ms on a RaspberryPi (B model).

  17. Adaptation of microalgae to a gradient of continuous petroleum contamination.

    PubMed

    Carrera-Martinez, Daniel; Mateos-Sanz, Aranzazu; Lopez-Rodas, Victoria; Costas, Eduardo

    2011-01-25

    In order to study adaptation of microalgae to petroleum contamination, we have examined an environmental stress gradient by crude oil contamination in the Arroyo Minero River (AMR), Argentina. Underground crude oil has constantly leaked out since 1915 as a consequence of test drilling for possible petroleum exploitation. Numerous microalgae species proliferated in AMR upstream of the crude oil spill. In contrast, only four microalgal species were detected in the crude oil spill area. Species richness increases again downstream. Microalgae biomass in the crude oil spill area is dominated by a mesophile species, Scenedesmus sp. Effects of oil samples from AMR spill on photosynthetic performance and growth were studied using laboratory cultures of two Scenedesmus sp. strains. One strain (Se-co) was isolated from the crude oil spill area. The other strain (Se-pr) was isolated from a pristine area without petroleum contamination. Crude oil has undetectable effects on Se-co strain. In contrast crude oil rapidly destroys Se-pr strain. However, Se-pr strain can adapt to low doses of petroleum (≤ 3% v/v total hydrocarbons/water) by means of physiological acclimatization. In contrast, only rare crude oil-resistant mutants are able to grow under high levels of crude oil (≥ 10% v/v total hydrocarbons/water). These crude oil-resistant mutants have arisen through rare spontaneous mutations that occur prior to crude oil exposure. Species richness in different areas of AMR is closely connected to the kind of mechanism (genetic adaptation vs. physiological acclimatization) that allows adaptation. Resistant-mutants are enough to assure the survival of microalgal species under catastrophic crude oil spill. PMID:21216344

  18. The role of snow cover in ground thermal conditions in three sites with contrasted topography in Sierra Nevada (Spain)

    NASA Astrophysics Data System (ADS)

    Oliva, Marc; Salvador, Ferran; Gómez Ortiz, Antonio; Salvà, Montserrat

    2014-05-01

    Snow cover has a high capacity to insulate the soil from the external thermal influences. In regions of high snowfall, such as the summit areas of the highest Iberian mountain ranges, the presence of a thick snow cover may condition the existence or inexistence of permafrost conditions. In order to analyze the impact of the thickness, duration and interannual variability of snow cover on the ground thermal regime in the massif of Sierra Nevada, we have analyzed soil temperatures at a depth of 2 cm for the period 2006-2012 in three sites of contrasting topography as well as air temperatures for the same period: (a) Corral del Veleta (3100 m) in a rock glacier located in the northern Veleta cirque, with high and persistent snow cover. (b) Collado de los Machos (3300 m), in a summit area with relict stone circles, with little snow accumulation due to wind effect. (c) Río Seco (3000 m), in a solifluction lobe located in this southern glacial cirque with moderate snowfall. Considering the air and 2 cm depth soil temperature records, the freezing degree-days were calculated for each year from November to May in order to characterize the role of snow as a thermal insulator of the ground during the cold season (Frauenfeld et al., 2007). In all cases, the highest values of freezing degree-days correspond to years with little snowfall (2006-2007, 2007-2008, 2011-2012), while in years with a thicker snow cover (2008-2009, 2009-2010, 2010-2011) the total freezing degree-days were significantly lower. The accumulation of freezing degree-days is maximum at the wind-exposed site of Collado de los Machos, where the wind redistributes snow and favours the penetration of cold into the ground. The opposite pattern occurs in the Veleta cirque, where most persistent snow cover conditions determine lower accumulated freezing degree-days than in Collado de los Machos and Rio Seco.

  19. Conversion to drip irrigated agriculture may offset historic anthropogenic and wildfire contributions to sediment production.

    PubMed

    Gray, A B; Pasternack, G B; Watson, E B; Goñi, M A; Hatten, J A; Warrick, J A

    2016-06-15

    This study is an investigation into the roles of wildfire and changing agricultural practices in controlling the inter-decadal scale trends of suspended sediment production from semi-arid mountainous rivers. In the test case, a decreasing trend in suspended sediment concentrations was found in the lower Salinas River, California between 1967 and 2011. Event to decadal scale patterns in sediment production in the Salinas River have been found to be largely controlled by antecedent hydrologic conditions. Decreasing suspended sediment concentrations over the last 15years of the record departed from those expected from climatic/hydrologic forcing. Sediment production from the mountainous headwaters of the central California Coast Ranges is known to be dominated by the interaction of wildfire and large rainfall/runoff events, including the Arroyo Seco, an ~700km(2) subbasin of the Salinas River. However, the decreasing trend in Salinas River suspended sediment concentrations run contrary to increases in the watershed's effective burn area over time. The sediment source area of the Salinas River is an order of magnitude larger than that of the Arroyo Seco, and includes a more complicated mosaic of land cover and land use. The departure from hydrologic forcings on suspended sediment concentration patterns was found to coincide with a rapid conversion of irrigation practices from sprinkler and furrow to subsurface drip irrigation. Changes in agricultural operations appear to have decreased sediment supply to the Salinas River over the late 20th to early 21st centuries, obscuring the influence of wildfire on suspended sediment production. PMID:26974570

  20. Ticks (Acari: Ixodidae) on wild birds in north-central Argentina.

    PubMed

    Flores, Fernando S; Nava, Santiago; Batallán, Gonzalo; Tauro, Laura B; Contigiani, Marta S; Diaz, Luis A; Guglielmone, Alberto A

    2014-10-01

    Ixodid ticks were collected from wild birds in five ecoregions in north-central Argentina, namely: Selva de las Yungas, Esteros del Iberá, Delta e Islas del Paraná, Selva Paranaense and Chaco Seco. A total of 2199 birds belonging to 139 species, 106 genera, 31 families and 11 orders were captured, but ticks were collected only from 121 birds (prevalence=5.5%) belonging to 39 species (28.1%) and three Orders: Tinamiformes (Tinamidae) and Falconiformes (Falconidae) in Selva de las Yungas and Passeriformes (Conopophagidae, Corvidae, Emberizidae, Furnariidae, Icteridae, Parulidae, Thamnophilidae, Thraupidae, Troglodytidae, Turdidae) for all ecoregions. The following tick species were found: Haemaphysalis juxtakochi, Haemaphysalis leporispalustris, Ixodes pararicinus plus Amblyomma sp. and Haemaphysalis sp. in Selva de las Yungas; Amblyomma triste and Ixodes auritulus in Delta e Islas del Paraná; Amblyomma dubitatum, A. triste and Amblyomma sp. in Esteros del Iberá; Amblyomma ovale and Amblyomma sp. in Selva Paranaense, and Amblyomma tigrinum in Chaco Seco. Amblyomma dubitatum was found for the first time on Passeriformes, while the records of A. ovale on avian hosts are the first for Argentina. Birds are also new hosts for I. pararicinus females. Besides 2 larvae and 1 nymph, and 1 larvae found on Tinamidae (Tinamiformes) and Falconidae (Falconiformes), respectively, all other ticks (691 larvae, 74 nymphs and 2 females) were found on Passeriformes with a relevant contribution of the family Turdidae. Birds are important hosts for I. pararicinus as shown by a prevalence of 45% while all others prevalence were below 15%. All the species of Amblyomma and Haemaphysalis found on birds in Argentina have been also detected on humans and are proven or potential vectors for human diseases. Therefore, their avian hosts are probable reservoirs of human pathogens in Argentina. PMID:25108788

  1. Meta-Analysis of Attitudes toward Damage-Causing Mammalian Wildlife

    PubMed Central

    KANSKY, RUTH; KIDD, MARTIN; KNIGHT, ANDREW T

    2014-01-01

    íferos Silvestres Causantes de Daños Resumen Muchas poblaciones de mamíferos amenazados persisten fuera de áreas protegidas formales y su supervivencia depende de la buena voluntad de las comunidades que coexisten con ellos. Un entendimiento de las posturas, y específicamente de la tolerancia, de los individuos y las comunidades y los factores que los determinan es fundamental para diseñar estrategias que alivien el conflicto humano – vida silvestre. Llevamos a cabo un meta-análisis para identificar los factores que afectaron las posturas hacia cuatro grupos de mamíferos terrestres. Los elefantes (65%) provocaron las posturas más positivas. Los siguieron los primates (55%), los ungulados (53%) y los carnívoros (44%). Los residentes urbanos presentaron las posturas más positivas (80%), seguidos por los granjeros comerciales (51%) y los granjeros comunales (26%). Un índice de tolerancia a los daños mostró que la tolerancia humana a los ungulados y primates fue proporcional a la probabilidad de experimentar daños mientras que los elefantes provocaron niveles de tolerancia más altos de lo esperado y los carnívoros provocaron niveles de tolerancia más bajos de lo esperado. Contrario a la sabiduría convencional, experimentar daños no fue siempre el factor dominante para determinar las posturas. Los granjeros comunales tuvieron una baja probabilidad de ser positivos hacia los carnívoros independientemente de la probabilidad de experimentar daños, mientras que los granjeros comerciales y los residentes urbanos tuvieron mayor probabilidad de ser positivos hacia los carnívoros independientemente de los daños. Los residentes urbanos tuvieron mayor probabilidad de ser positivos hacia los ungulados, los elefantes y los primates cuando la probabilidad de daños fue baja, pero no cuando fue alta. Los granjeros comerciales y comunales tuvieron una mayor probabilidad de ser positivos hacia los ungulados, los primates y los elefantes independientemen

  2. [Aluminum content in individual components, used to prepare adult total parenteral nutrition mixtures in Argentine, and in comparison with international regulation].

    PubMed

    Menéndez, A M; Farías, S S; Servant, R; Morisio, Y; Misischia, Y; Simón, S; Weisstaub, A R; Martín de Portela, M L Pita

    2014-06-01

    Introducción: aluminio (Al) es un elemento tóxico que puede ser contaminante de productos farmacéuticos utilizados para preparar mezclas de nutrición parenteral (NP). Objetivos: 1) determinar la concentración de Al en componentes individuales utilizados para preparar mezclas de NP; 2) comparar las cantidades detectadas con los límites de la regulación internacional (FDA); 3) calcular la cantidad de Al administrada en fórmulas habituales de NP para neonatos, niños y adultos. Materiales y métodos: El Aluminio fue determinado por Espectroscopía de Emisión Atómica-Plasma-Inductivo de Argón (Perkin Elmer 5100 DV) en 44 productos comerciales, de diferentes laboratorios y lotes, correspondientes a 16 componentes individuales: dextrosa; aminoácidos para adultos y pediátricos; lípidos; cloruro de potasio; cloruro de sodio, sulfato de magnesio; fosfato de sodio; gluconato de calcio; glicerofosfato de sodio; sulfato de zinc; elementos multitraza; agua estéril en ampollas y de gran volumen. Resultados: Todos los componentes de gran volumen, excepto el agua, contenían entre 249 y 1.580 μg/L, superando entre 4 y 180 veces mas que los niveles establecidos por la FDA (25 μg/L). Los componentes de pequeño volumen contenían entre 85 y 4.909 μg/L, no declarados en los rótulos. Conclusiones: 1) La mayor cantidad de aluminio se encontró en el gluconato de calcio, fosfato de sodio y elementos multitraza. 2) Las mezclas de uso habitual para NP presentan niveles de Al mayores al límite de FDA. Los componentes que aportan mayor cantidad de aluminio en las mezclas de NP para adultos son: glucosa, aminoácidos y lípidos, pero en las de neonatos, el mayor aporte proviene de la dextrosa y gluconato de calcio. 3) En las mezclas de NP para neonatos, niños y adultos la cantidad de aluminio administrado por kg de peso supera la recomendación de FDA (5 μg/kg de peso /día). Los productos comerciales deberían declarar el contenido de Al para no comprometer la evoluci

  3. [In Process Citation].

    PubMed

    Durán Agüero, Samuel; Herrera Valenzuela, Tomás; Poblete Aro, Carlos; Durán Acevedo, Angelo; Valdés Badilla, Pablo

    2016-03-25

    Objetivo: determinar los patrones alimentarios de ultramaratonistas chilenos. Métodos: estudio descriptivo transversal, con enfoque cuantitativo. La muestra incluyó 20 ultramaratonistas (n = 3 mujeres), quienes promediaban para la edad 33,0 ± 7,8 años, peso 71,1 ± 6,6 kg y estatura 1,72 ± 0,05 m. Se aplicó una encuesta de hábitos alimentarios validada y un punto de significación de p < 0,05. Resultados: los ultramaratonistas chilenos presentan bajo consumo de alimentos de acuerdo a las porciones recomendadas de frutas, verduras, pescado y leguminosas, y el 75% de ellos consume desayuno diariamente. Se observa ingestas moderadas de bebidas azucaradas, snacks dulces y alcohol, mientras que la ingesta de frituras (65%) corresponde al hábito no saludable más frecuente. Conclusión: los ultramaratonistas chilenos presentan un bajo cumplimiento en las porciones recomendadas de alimentos, pese al gran esfuerzo físico que realizan.

  4. [In Process Citation].

    PubMed

    Durán Agüero, Samuel; Herrera Valenzuela, Tomás; Poblete Aro, Carlos; Durán Acevedo, Angelo; Valdés Badilla, Pablo

    2016-01-01

    Objetivo: determinar los patrones alimentarios de ultramaratonistas chilenos. Métodos: estudio descriptivo transversal, con enfoque cuantitativo. La muestra incluyó 20 ultramaratonistas (n = 3 mujeres), quienes promediaban para la edad 33,0 ± 7,8 años, peso 71,1 ± 6,6 kg y estatura 1,72 ± 0,05 m. Se aplicó una encuesta de hábitos alimentarios validada y un punto de significación de p < 0,05. Resultados: los ultramaratonistas chilenos presentan bajo consumo de alimentos de acuerdo a las porciones recomendadas de frutas, verduras, pescado y leguminosas, y el 75% de ellos consume desayuno diariamente. Se observa ingestas moderadas de bebidas azucaradas, snacks dulces y alcohol, mientras que la ingesta de frituras (65%) corresponde al hábito no saludable más frecuente. Conclusión: los ultramaratonistas chilenos presentan un bajo cumplimiento en las porciones recomendadas de alimentos, pese al gran esfuerzo físico que realizan. PMID:27238804

  5. Antibiotic treatments in zootechnology and effects induced on the food chain of domestic species and, comparatively, the human specie.

    PubMed

    Palmieri, Beniamino; Di Cerbo, Alessandro; Laurino, Carmen

    2014-06-01

    Introducción: los antibióticos se emplean ampliamente en la alimentación zootécnica para proteger a las especies humana y animal de las zoonosis por agentes infecciosos patogénicos. Objetivo: dado el creciente número de enfermedades relacionadas con la dieta (p. ej., intolerancias alimentarias), investigamos los efectos tóxicos inducidos por los residuos antibióticos, oxitetraciclinas, presentes en los alimentos industriales tanto sobre la salud humana como animal. Se destacan los productos zootécnicos obtenidos de la transformación industrial de los huesos animales y sus efectos tóxicos relacionados. Métodos: análisis comparativo de las publicaciones realizadas desde 1910 hasta 2014. Resultados: el análisis comparativo reveló la presencia de residuos de oxitetraciclina y otros antibióticos en alimentos pensados para el consumo humano y animal, lo que produjo efectos tóxicos multisistémicos. Discusión: el metabolismo y las posibles medidas para evitar la exposición a la oxitetraciclina también se han examinado, sin embargo, se precisa de un conocimiento más detallado de los efectos bioquímicos de tal clase de antibióticos.

  6. The Spanish diet: an update.

    PubMed

    Varela-Moreiras, Gregorio; Ruiz, Emma; Valero, Teresa; Avila, José Manuel; del Pozo, Susana

    2013-09-01

    Antecedentes/objetivos: La Encuesta de Consumo de Alimentos, realizada durante 20 años por el Ministerio de Agricultura, Alimentación y Medio Ambiente (MAGRAMA), es la fuente más fiable de datos para evaluar el consumo de alimentos y patrones dietéticos en España. El objetivo de este artículo fue revisar las tendencias dietéticas en España y su evolución. Se describe la evaluación de la disponibilidad de alimentos per cápita y día, que permite el cálculo de consumo de energía y nutrientes y su comparación con el Consumo Recomendado de Nutrientes para la población española. Además, se han evaluado diferentes marcadores de la calidad de la dieta. Métodos: La muestra consistió en los datos de consumo y distribución, obtenidos de la Encuesta Nacional de Consumo de Alimentos para el período 2000-2012. Se aplicó un método de muestreo en dos etapas en el que, en la primera etapa, las unidades que se muestreaban fueron ciudades y entidades locales y, en la segunda, se seleccionaron los hogares que conformaron la muestra final a partir de las entidades locales. Las unidades consistieron en ciudades o entidades locales del territorio nacional. Los datos permitieron el cálculo de consumo de energía y nutrientes utilizando las tablas de Consumo de Alimentos (Moreiras et al., 2013). También se evaluó la calidad de la dieta: la adecuación de la dieta para alcanzar los consumos de energía y nutrientes recomendados; perfil de energía; calidad de la grasa de la dieta; calidad de la proteína de la dieta; densidad de nutrientes; índices de adecuación de la dieta mediterránea. Los datos actuales se compararon con los datos previos obtenidos por nuestro grupo de investigación en 1964, 1981 y 1991. Resultados: Utilizando los datos más recientes, el consumo promedio comprendía: leche y derivados (356 g/persona/día), frutas (323 g/persona/día), verduras y hortalizas (339 g/persona/día), cereales y derivados (197 g/persona/día), carne y productos c

  7. [A FOOD FREQUENCY QUESTIONNAIRE TO ASSESS DIET QUALITY IN THE PREVENTION OF IRON DEFICIENCY].

    PubMed

    Toxqui Abascal, Laura; Díaz Álvarez, Alejandra; Vaquero, María Pilar

    2015-09-01

    Introducción: A pesar del amplio conocimiento sobre la biodisponibilidad del hierro, no se ha implementado aún un cuestionario de frecuencia de consumo de alimentos (CFCA) para su aplicación en grupos poblacionales con predisposición a anemia. Objetivos: Diseñar un CFCA basado en los potenciadores e inhibidores de la absorción del hierro y valorar su aplicabilidad en un grupo de mujeres en edad fértil. Métodos: Se elaboró un CFCA específico de 28 preguntas, 10 de ellas con indicación del momento de consumo de alimentos, en el desayuno y en comida/cena (CC). Se seleccionaron 179 mujeres sanas jóvenes que se distribuyeron en 3 grupos en función de su estado del hierro, ferritina sérica 30 ng/mL. Resultados: La reproducibilidad del CFCA fue muy alta (coeficiente de Spearman>0.500, p.

  8. [Implementation of the food choice questionnaire in young adolescents and their relationship to overweight and other socio-demographic variables].

    PubMed

    Canales Ronda, Pedro; Hernández Fernández, Asunción

    2015-05-01

    Objetivo: El objetivo del presente trabajo se centra en analizar el comportamiento en la elección de los alimentos entre los jóvenes adolescentes españoles, así como su efecto sobre los posibles problemas relacionados con su peso (sobrepeso y obesidad) y otras variables socio-demográficas. Método: En el estudio participaron 590 alumnos de colegios públicos y privados de la ciudad de Valencia, con edades entre los 14 y 17 años, elegidos aleatoriamente. Se realizó un cuestionario personal basado en el Food Choice Questionaire. Resultados: En general, los jóvenes eligen sus alimentos en función de los aspectos sensoriales y el precio de los mismos, y no les preocupan los efectos que sobre su peso tienen sus hábitos alimentarios. No se detectan diferencias entre los alumnos de centros públicos o privados, ni tampoco entre aquellos con normopeso o sobrepeso. Si que existe alguna diferencia en cuanto al género del encuestado. Conclusiones: Los adolescentes, a la hora de elegir su alimentación, no son muy conscientes de los posibles efectos de los mismos sobre su salud actual y futura.

  9. [Trends in food consumption of university students].

    PubMed

    De Piero, Alexia; Bassett, Natalia; Rossi, Analia; Sammán, Norma

    2015-04-01

    Los jóvenes universitarios necesitan consolidar buenos hábitos alimentarios basados en una adecuada selección de alimentos, los cuales constituyen un factor de fundamental importancia para mantener un buen estado de salud y prevenir enfermedades. Objetivo: Evaluar la ingesta de alimentos y el perfil de la dieta de estudiantes universitarios de Tucumán y su variación a través del tiempo. Analizar si cumplen las recomendaciones dietéticas actuales. Materiales y métodos: La recolección de datos se llevó a cabo durante los años 1998-1999 (G1) y 2012-2013 (G2); se realizó mediante una autoencuesta alimentaria y cuestionario de frecuencia de consumo de alimentos. Fue aplicada a 329 estudiantes universitarios seleccionados en forma aleatoria. El perfil alimentario se describió según la frecuencia de consumo habitual de los principales grupos de alimentos. Resultados: Los estudiantes resultaron 25,2% hombres y 74,8% mujeres, con edad promedio de 23±3 años. En general, en ambos grupos, la mayoría de los estudiantes presentó un IMC normal, sin embargo se destacó un elevado porcentaje de hombres con sobrepeso (18,2%) y obesidad (12,1%) y mujeres con bajo peso (11,6%). Según los grupos analizados y en función del sexo se observaron algunas diferencias estadísticamente significativas en la composición de macronutrientes de la dieta: en G1 fue mayor el consumo de carbohidratos en detrimento de proteínas y lípidos; se encontraron también diferencias en la ingesta de algunos micronutrientes, observándose mayor consumo de hierro y menor de vitaminas B1, B2, niacina y C en el G2. La dieta fue monótona para ambos grupos y con diferencias en el perfil de nutrientes que la conforman. La más notable fue el incremento gradual del consumo de productos azucarados, alimentos procesados, snacks y menor consumo de lácteos, pescados, frutas y vegetales en el G2. En ambos grupos, la adecuación de la ingesta alimentaria de la población estudiantil no cubrió las

  10. [CAFFEINE AND QUININE IN SOFT DRINKS; CONTRIBUTION TO THE DIETARY INTAKE].

    PubMed

    González Reyes, Ana Belén; Hardisson de la Torre, Arturo; Gutiérrez Fernández, Angel José; Rubio Armendáriz, Carmen; Frías Tejera, Inmaculada; Revert Gironés, Consuelo

    2015-12-01

    Introducción: las bebidas refrescantes son cada vez más consumidas por la sociedad. Están compuestas por una gran variedad de sustancias, de las cuales algunas, si se consumen en dosis altas y con elevada frecuencia, pueden provocar efectos negativos. Objetivos: determinar la concentración de cafeína y quinina para comprobar si sus niveles se encuentran por debajo de los máximos permitidos por la reglamentación técnico-sanitaria vigente y calcular la contribución a la ingesta dietética obteniendo la Ingesta Diaria Estimada. Método: se analizaron las concentraciones de cafeína y quinina en las principales marcas comerciales de refrescos, usando para ello la técnica de cromatografía líquida de alta resolución. Resultados: se obtuvieron concentraciones para todas las marcas analizadas, que permitieron estimar la media en cada una. Conclusiones: se ha observado que en ningún caso se superan las concentraciones máximas y que la contribución a la ingesta no genera aparición alguna de reacción adversa.

  11. Preliminary Evaluation of Removing Used Nuclear Fuel from Shutdown Sites

    SciTech Connect

    Maheras, Steven J.; Best, Ralph E.; Ross, Steven B.; Buxton, Kenneth A.; England, Jeffery L.; McConnell, Paul E.; Massaro, Lawrence M.; Jensen, Philip J.

    2014-10-01

    This report presents a preliminary evaluation of removing used nuclear fuel (UNF) from 12 shutdown nuclear power plant sites. At these shutdown sites the nuclear power reactors have been permanently shut down and the sites have been decommissioned or are undergoing decommissioning. The shutdown sites are Maine Yankee, Yankee Rowe, Connecticut Yankee, Humboldt Bay, Big Rock Point, Rancho Seco, Trojan, La Crosse, Zion, Crystal River, Kewaunee, and San Onofre. The evaluation was divided into four components: characterization of the UNF and greater-than-Class C low-level radioactive waste (GTCC waste) inventory; a description of the on-site infrastructure and conditions relevant to transportation of UNF and GTCC waste; an evaluation of the near-site transportation infrastructure and experience relevant to shipping transportation casks containing UNF and GTCC waste, including identification of gaps in information; and, an evaluation of the actions necessary to prepare for and remove UNF and GTCC waste. The primary sources for the inventory of UNF and GTCC waste are the U.S. Department of Energy (DOE) RW-859 used nuclear fuel inventory database, industry sources such as StoreFUEL and SpentFUEL, and government sources such as the U.S. Nuclear Regulatory Commission. The primary sources for information on the conditions of site and near-site transportation infrastructure and experience included observations and information collected during visits to the Maine Yankee, Yankee Rowe, Connecticut Yankee, Humboldt Bay, Big Rock Point, Rancho Seco, Trojan, La Crosse, and Zion sites; information provided by managers at the shutdown sites; Facility Interface Data Sheets compiled for DOE in 2005; Services Planning Documents prepared for DOE in 1993 and 1994; industry publications such as Radwaste Solutions; and Google Earth. State and Regional Group representatives, a Tribal representative, and a Federal Railroad Administration representative participated in six of the shutdown site

  12. [RISK OF MALNUTRITION ASSOCIATED WITH POOR FOOD INTAKE, PROLONGED HOSPITAL STAY AND READMISSION IN A HIGH COMPLEXITY HOSPITAL IN COLOMBIA].

    PubMed

    Vesga Varela, Andrea Liliana; Gamboa Delgado, Edna Magaly

    2015-09-01

    Introducción: la desnutrición hospitalaria es altamente prevalente y se relaciona con estancias hospitalarias prolongadas, aumento de costes de la atención y complicaciones clínicas asociadas. Objetivo: determinar el riesgo de desnutrición en pacientes hospitalizados en una institución de cuarto nivel de atención y sus factores asociados. Métodos: se aplicaron los cuestionarios de la iniciativa Nutrition Day a 70 pacientes adultos de una institución de salud de alto nivel de complejidad, en Bucaramanga, Colombia. Los parámetros del estudio incluyeron datos antropométricos y demográficos, historia clínica, factores relacionados a la dieta y percepción del estado de salud. Se aplicó el Malnutrition Screenning Tool (MST, por sus siglas en inglés) para medir el riesgo de desnutrición. Para establecer las razones de prevalencia (RP) se utilizaron modelos de regresión binomial. Resultados: la edad y los días de estancia hospitalaria, en el momento de la medición basal fueron, en promedio, 61,89 ± 15,17 años y 7,96 ± 9,79 días. La prevalencia de riesgo de desnutrición fue 52,86% (IC 95%: 40,55% - 64,91%); 40,91% en mujeres y 58,33% en hombres (p = 0,175). Un 18,57% de los pacientes no consumió alimento alguno en el almuerzo. Un 40,00% de los participantes manifestó haber tenido una ingesta de alimentos menor a la normal, durante la última semana. Las variables asociadas a riesgo de desnutrición, ajustadas por edad y sexo, fueron: ingesta de alimentos al corte del estudio, reingreso y días de estancia hospitalaria al seguimiento. Conclusión: la evidencia sobre la importancia del diagnóstico temprano y el manejo nutricional adecuado de la desnutrición hospitalaria indican la necesidad de implementar intervenciones nutricionales efectivas.

  13. [Food-related lifestyles and eating habits inside and outside the home in the Metropolitan Region of Santiago, Chile].

    PubMed

    Schnettler, Berta; Peña, Juan Pablo; Mora, Marcos; Miranda, Horacio; Sepúlveda, José; Denegri, Marianela; Lobos, Germán

    2013-01-01

    Objetivo: Distinguir tipologías de consumidores en base a su estilo de vida en relación a la alimentación en las principales comunas de la Región Metropolitana de Santiago, Chile, y caracterizarlas según sus hábitos de consumo de alimentos dentro y fuera del hogar, características sociodemográficas y su nivel de satisfacción con su alimentación. Material y método: Se aplicó un cuestionario estructurado a una muestra de 951 personas en las principales comunas de la Región Metropolitana de Santiago (más de 100.000 habitantes). El instrumento de recogida de información incluyó una adaptación del cuestionario de estilos de vida en relación a la alimentación (FRL) y la escala SWFL (Satisfaction with Food-related Life). Se consultaron los hábitos de consumo de alimentos dentro y fuera del hogar y variables de clasificación sociodemográfica de los encuestados. Resultados: Mediante análisis cluster se distinguieron cinco tipologías con diferencias significativas en los cinco componentes obtenidos del FRL, con análisis factorial de componentes principales. Las tipologías presentaron distinto perfil de género, edad y nivel socioeconómico y difirieron en los puntajes obtenidos en la SWFL. Se diferenciaron en la frecuencia en que la persona almuerza, toma once y cena en su hogar. Respecto a las comidas fuera del hogar, las tipologías se distinguieron según la frecuencia de comidas en restaurantes, locales de comida rápida y en la compra de comida preparada. Conclusiones: Un estilo de vida en relación a la alimentación con baja implicación y disfrute de los alimentos se asocia con un mayor nivel socioeconómico y menor edad de las personas. Adicionalmente, se asocia con comportamientos alimentarios poco saludables y no beneficiosos para las personas, como una mayor frecuencia de comidas en restaurantes y de compra de comida preparada, junto a una menor frecuencia de comidas en el hogar, lo que estaría influyendo en un nivel inferior de

  14. [Consumption of eggs may prevent vitamin D deficiency in schoolchildren].

    PubMed

    Rodríguez-Rodríguez, Elena; González-Rodríguez, Liliana G; Ortega Anta, Rosa María; López-Sobaler, Ana María

    2013-01-01

    Introducción: La vitamina D es esencial para la prevención de diversas enfermedades crónicas. Aunque se puede sintetizar a nivel cutáneo, esta fuente no es siempre suficiente para cubrir sus necesidades, por lo que el consumo de alimentos ricos en la misma, como el huevo, podría ser muy beneficioso en individuos que están en riesgo de presentar deficiencia. Objetivo: Estudiar la relación entre el estatus en vitamina D y el consumo diario de huevos en un colectivo de escolares. Metodología: Se incluyeron 564 escolares (9 a 12 años) de la Comunidad de Madrid. La ingesta de alimentos, de energía y nutrientes (incluidos el huevo y la vitamina D), se determinó empleando un registro del consumo de alimentos durante 3 días. Se calculó el Índice de Masa Corporal a través del peso corporal y la talla. Se valoró el colesterol total, lipoproteínas, triglicéridos y vitamina D sérica. Resultados: El consumo medio de huevos fue de 32,7 ± 20,9 g/día (inferior a 0,5 huevo/día recomendados en el 36,3% de los escolares). Se dividió a los escolares en función de que tuvieran un consumo ≥?o < 0,5 huevo/día (grupos SH e IH, respectivamente). La ingesta y los niveles séricos de vitamina D fueron significativamente superiores en el grupo SH que en el IH. Además, los primeros tuvieron menor riesgo de presentar deficiencia moderada de vitamina D (< 50 nmol/L) (OR = 0,41 (0,19-0,88); p = 0,022). No se observaron diferencias significativas entre los grupos en relación con las cifras de colesterol total y triglicéridos. Conclusión: Es recomendable fomentar el consumo deal menos 0,5 huevo/día entre la población infantil debidoa su alto contenido en vitamina D, lo que podría evitar laaparición de problemas de salud.

  15. A REVIEW OF GRAPHICAL REPRESENTATIONS USED IN THE DIETARY GUIDELINES OF SELECTED COUNTRIES IN THE AMERICAS, EUROPE AND ASIA.

    PubMed

    Altamirano Martínez, Martha Betzaida; Cordero Muñoz, Aida Yanet; Macedo Ojeda, Gabriela; Márquez Sandoval, Yolanda Fabiola; Vizmanos, Barbara

    2015-09-01

    Introducción: las Guías Alimentarias Basadas en Alimentos “Food-Based Dietary Guidelines” (FBDG) son una propuesta de la Food and Agriculture Organization of the United Nations (FAO) y la World Health Organization (WHO) para que cada país plantee sus principios de educación nutricional de manera clara y concreta con el fin de orientar y promover la buena salud en la población. Muchas de estas guías incluyen una representación gráfica (GR) como ayuda visual en el proceso de orientación alimentaria. Objetivos: analizar las características de las GR de países de tres continentes, para conocer las tendencias internacionales de los mensajes gráficos y para facilitar su transmisión durante el proceso educativo a la población a la que van dirigidos. Métodos: revisión de las GR de las FBDG de países de América, Europa y Asia, cuya información estuviera accesible, en español o en inglés. Resultados y discusión: las figuras más utilizadas son el círculo y la pirámide. Las GR ilustran las siguientes recomendaciones: todas (n = 37) grupos de alimentos, 21 actividad física, 17 consumo de agua, 7 restricción de sal, 1 convivencia familiar, 1 relajación y 10 recomendaciones cuantitativas. Las GR de Grecia y Estados Unidos no muestran imágenes de alimentos. Los aspectos considerados en las GR dependen de la región, la cultura y algunas características epidemiológicas de cada país. Se observa una tendencia al uso de la figura del círculo en países como Estados Unidos, España y México, además de incluir recomendaciones sobre el estilo de vida en la ilustración. Las recomendaciones cuantitativas pueden clarificar la información en el proceso educativo.

  16. [Clinical-epidemiological profile of patients with suspicion of alimentary allergy in Mexico. Mexipreval Study].

    PubMed

    Medina-Hernández, Alejandra; Huerta-Hernández, Rosa Elena; Góngora-Meléndez, Marco A; Domínguez-Silva, M Gabriela; Mendoza-Hernández, David A; Romero-Tapia, Sergio J; Iduñate-Palacios, Fernando; Cisneros-Rivero, María Gozos; Covarrubias-Carrillo, Rosa Martha; Juan-Pineda, María Ángeles; Zárate-Hernández, María Carmen

    2015-01-01

    Antecedentes: las enfermedades alérgicas asociadas con alimentos se incrementan anualmente. Tienen una prevalencia de 2 a 4% en adultos y de 6 a 8% en niños. El cuadro clínico varía de síntomas leves hasta reacciones anafilácticas. El diagnóstico se basa en la historia clínica, pero debe demostrarse evidencia de sensibilización específica para el alergeno. Objetivo: conocer el perfil clínico-epidemiológico de los pacientes con sospecha de alergia alimentaria vistos en consultorios médicos (alergólogos y no alergólogos), así como la conducta diagnóstica y tratamiento habitual. Material y método: estudio observacional, transversal y descriptivo, efectuado en consultorios de médicos que atienden pacientes con alergia alimentaria en la República Mexicana durante un año natural de abril de 2013 a marzo de 2014, mediante un muestreo por conveniencia. Resultados: se realizaron 1,971 encuestas. No se encontró diferencia en relación con el género. En relación con la edad, se reportó una distribución bimodal, con picos a los 2 y 35 años de edad. Había antecedente de alergia respiratoria en 75% de los casos. El 80% de los pacientes tuvo algún síntoma antes de buscar atención y las manifestaciones clínicas más frecuentes afectaron la piel (57.1%). El 5% refirió haber padecido al menos un evento de anafilaxia. Conclusión: el tipo de alimento implicado cambia con la edad. La forma de manifestación clínica más frecuente fue la cutánea, pero varía con el tipo de alimento. Aun cuando la sospecha clínica sea alta, deben utilizarse métodos específicos que confirmen el diagnóstico.

  17. EVALUATION OF DIET ACCEPTANCE BY PATIENTS WITH HAEMATOLOGICAL CANCER DURING CHEMOTHERAPEUTIC TREATMENT.

    PubMed

    Prockmann, Stéphanie; Ruschel Freitas, Ana Helena; Gonçalves Ferreira, Marilyn; Kunradi Vieira, Francilene Gracieli; Kuerten de Salles, Raquel

    2015-08-01

    Introducción: el estado nutricional amenazado es uno de los factores que puede elevar la morbimortalidad de los pacientes sometidos a quimioterapia. El objetivo de este estudio fue evaluar la aceptación de la dieta por parte de pacientes con cáncer hematológico durante la internación para quimioterapia. Métodos: investigación transversal, descriptiva y cuantitativa llevada a cabo entre febrero y octubre de 2014 con pacientes adultos de ambos sexos diagnosticados de linfoma y leucemia. Se realizó la evaluación diaria del consumo alimentario mediante la utilización de herramientas para colección de datos preparado por el autor. Se utilizó ANOVA para medidas repetidas. Resultados: fueron evaluados 32 pacientes con edad promedio de 42 ± 11 años, siendo la mayoría mujeres (66%). Observamos trastornos gastrointestinales en el 72% de los pacientes, la mayoría de las molestias fueron náuseas (59%) además de xerostomía (34%), vómitos (28%), inapetencia (28%) y disgeusia (25%). El porcentaje de resto de ingesta alimentaria fue significativo, oscilando entre el 23% y el 35%. El mayor rechazo ocurrió en el almuerzo y la cena. Las meriendas fueron mejor aceptadas, con un porcentaje del 75% al 100%. Conclusión de la investigación: los registros de alimentos mostraron que durante los ciclos de quimioterapia se produjo un rechazo significativo de alimentos sobre todo en las comidas de mayor volumen, como el almuerzo y la cena, mientras que las comidas pequeñas, tales como aperitivos, son mejor toleradas. El uso de opciones de alimentos enumerados por los pacientes puede ser una estrategia para mejorar el cumplimiento de la dieta. Se necesitan más estudios sobre este tema para mejorar la atención a esta población, con el objetivo de prevenir y/o recuperar el estado nutricional de estos pacientes.

  18. The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents.

    PubMed

    Dal Molin Netto, Bárbara; Landi Masquio, Deborah Cristina; Da Silveira Campos, Raquel Munhoz; De Lima Sanches, Priscila; Campos Corgosinho, Flavia; Tock, Lian; Missae Oyama, Lila; Túlio de Mello, Marco; Tufik, Sergio; Dâmaso, Ana Raimunda

    2014-02-01

    La Dieta de alto índice glucémico es un predictor independiente para explicar los cambios en la proteína relacionada al agouti en adolescentes obesos. Introducción y objetivos: El papel de la dieta de índice glucémico (GI) en el control de los factores orexigénicos y anorexígenos del balance de energía todavía no está claro. El presente estudio tuvo como objetivo evaluar si la dieta habitual, de acuerdo con diferentes alimentos con IG, ejerce influencia sobre la regulación de los marcadores del balance de energía y los efectos de la intervención interdisciplinaria en adolescentes obesos. Métodos: Un total de 55 adolescentes obesos, con edades de 14 a 19 años, han sido sometidos a un año de tratamiento interdisciplinario y se dividieron en dos grupos, de acuerdo al patrón de dieta predominante de la ingesta de alimentos: el grupo IG alto (H-GI; n = 29) y GI moderada/bajo grupo (M/L-GI, n = 26). Resultados: La concentración de orexigenic factor de AgRP (p < 0,01), la grasa visceral (p = 0,04) y la relación visceral/ subcutánea (p = 0,03) fueron mayores en el grupo de HGI en comparación con el grupo M/L-GI. Por otra parte, el consumo habitual de alimentos H-GI fue un predictor independiente para explicar los cambios en las concentraciones de AgRP. Después de un año de tratamiento interdisciplinario, los adolescentes presentan una reducción significativa en el peso corporal, la grasa corporal total (%), visceral y la grasa subcutánea y el HOMA-IR, así como un aumento significativo de la masa libre de grasa (%). Conclusiones: Nuestros resultados pueden sugerir que la dieta H-GI habitual podría upregulate vías orexigénicos, contribuyendo al círculo vicioso entre las dietas indeseables, desregula el equilibrio energético y predisponen a la obesidad. Uno por otro lado, un año de tratamiento interdisciplinario puede perfil metabólico mejora significativa y la obesidad central en los adolescentes.

  19. MICROBIOLOGICAL ASSESSMENT OF LETTUCE SALADS AND ANTIMICROBIAL RESISTANCE OF STAPHYLOCOCCUS SPP.

    PubMed

    Guimarães César, Josi; Madruga Peres, Andriele; Pereira das Neves, Caroline; Tupiniquim Freitas de Abreu, Érica; Fagundes de Mello, Jozi; Nunes Moreira, Ângela; Lameiro Rodrigues, Kelly

    2015-11-01

    Introducción: la procura por estabelecimientos que ofrecen alimentos prontos para consumo ha aumentado, sin embrago, los alimentos disponibles en estos locales pueden estar contaminados con microorganismos patogénicos, pudiendo causar enfermedades transmitidas por alimentos. Objetivos: evaluar la calidad microbiológica de las ensaladas de lechuga en los restaurantes de Pelotas RS Brasil, a través de los recuentos de coliformes termotolerantes, Escherichia coli, Staphylococcus spp. y la detección de Salmonella spp. Resistencia a los antimicrobianos de Staphylococcus spp. también se evalúan. Métodos: fueron colectadas 36 muestras de ensaladas de lechuga en nueve restaurantes y realizada la cuantificación de coliformes termotolerantes, Escherichia coli y Staphylococcus spp. e investigación de Salmonella spp., siguiendo la metodología del Bacteriological Analytical Manual. Los aislados de Staphylococcus spp. fueron sometidos al examen de resistencia a antimicrobianos por el método de difusión con discos. Resultados y discusión: de las 36 muestras de ensalada de lechuga, 61,1% presentaron cuantificación de coliformes termotolerantes superiores a lo permitido por la legislación brasileña, y hubo confirmación de E. coli en 5,6% de las muestras. La cuantificación de Staphylococcus coagulasa positiva representó 5,6% de los aislados y Staphylococcus coagulasa negativa representó 77,8%. Todas las muestras presentaron ausencia de Salmonella spp. De los 30 aislados de Staphylococcus spp. examinados, 56,7% fueron resistentes a penicilina, 46,7% a oxacilina, 26,7% a eritromicina y 23,3% fueron multirresistentes. Conclusión: la calidad microbiológica de las ensaladas de lechuga se mostró inadecuada debido a la presencia de microorganismos patogénicos, y los aislados de Staphylococcus spp. presentaron elevado porcentaje de resistencia antimicrobiana.

  20. [Not Available].

    PubMed

    Higuera Pulgar, Isabel; Bretón Lesmes, Irene; Carrascal Fabián, María Luisa; Prieto García, Alicia; Menchén Viso, Luis; Nogales Rincón, Óscar; Iglesias Hernández, Natalia Covadonga; Issasa Rodríguez, Leire; García Peris, Pilar

    2016-07-19

    Introducción: la esofagitis eosinofílica (EEo) es una enfermedad inmunoalérgica crónica emergente en adultos. Surge como respuesta disfuncional frente a los antígenos de los alimentos y se caracteriza por síntomas recurrentes de disfunción esofágica e inflamación. El tratamiento farmacológico y dietético se basa en su patogénesis y debe ser individualizado. Uno de los posibles abordajes dietéticos se basa en la eliminación empírica de alimentos que con mayor frecuencia causan EEo.Objetivo: evaluar la ingesta dietética de los pacientes con EEo que siguen la dieta de exclusión de los seis grupos de alimentos (DESGA) y conocer sus posibles carencias nutricionales.Métodos: estudio transversal descriptivo en un grupo de pacientes con EEo que inició tratamiento con DESGA durante el periodo de marzo de 2013 hasta marzo de 2015. Se evaluó la ingesta mediante registro de 72 horas. Se compararon los resultados con las referencias para población adulta sana española (23). Para el análisis estadístico se usaron los test de Mann-Whitney, Krhuskall-Wallis y Chi-cuadrado. Significación p < 0,05.Resultados: se incluyeron en el estudio 14 pacientes. En algunos de ellos, la ingesta dietética siguiendo DESGA fue deficitaria en energía, proteínas y fibra. Tampoco consiguieron cubrir las ingestas de micronutrientes de calcio, zinc, magnesio, ácido fólico, niacina y vitaminas B2 y D, teniendo en cuenta edad y sexo, el 60% de la muestra.Conclusiones: el abordaje terapéutico mediante DESGA, teniendo en cuenta las características de la dieta, debe acompañarse de una evaluación periódica del estado nutricional, que incluya micronutrientes y una pauta de suplementación específica.

  1. [ASSOCIATION OF OLFACTORY SENSITIVITY WITH ENERGY INTAKE: ROLE IN DEVELOPMENT OF OBESITY].

    PubMed

    Valladares Vega, Macarena; Obregón Rivas, Ana Maria

    2015-12-01

    La obesidad se produce por un desequilibrio entre la energía consumida y el gasto de energía generado. Dentro de los factores que regulan la ingesta no homeostática se encuentra el sentido del olfato, que constituye una importante señal externa que induce la ingesta de alimentos. Los humanos lo utilizan para apreciar la palatabilidad de los alimentos y, en general, para seleccionar alimentos. Materiales y método: se realizó una búsqueda electrónica de artículos en las bases de datos de Pubmed y Scielo, donde se utilizaron las palabras claves: “olfato”, “ingesta energética” y “obesidad”; adicionalmente se sumaron los siguientes límites para restringir la exploración: “animales”, “humanos”, “ensayo clínico” y “metaanálisis”. Resultados: el estado de hambre individual esta modulado por la sensibilidad olfatoria, donde se observa que la sensibilidad del olfato aumenta frente a un estado de ayunas. Existen dos hormonas que han permitido relacionar el sentido del olfato con la ingesta energética: orexina, que aumenta la sensibilidad olfativa y la ingesta, y leptina, que disminuye la sensibilidad olfativa y la ingesta. Las personas obesas con IMC > 45 presentan baja sensibilidad olfativa, situación que no varía después de la cirugía bariátrica. Conclusiones: determinar la relación entre el olfato, la ingesta energética y la obesidad es un campo escasamente estudiado y que abre nuevos caminos para el tratamiento de patologías en las que existen trastornos alimentarios como la obesidad. A futuro es necesario la realización de ensayos clínicos que permitan determinar la causalidad entre ambas variables, así como estudios moleculares para comprender mejor las señales que relacionan el olfato con la ingesta energética.

  2. EFFECT OF HYPOENERGETIC DIET COMBINED WITH CONSUMPTION OF COCONUT FLOUR IN OVERWEIGHT WOMEN.

    PubMed

    de Paula Franco, Elizabeth; Moraes de Oliveira, Gláucia Maria; Raggio Luiz, Ronir; Rosa, Glorimar

    2015-11-01

    Introducción: la prevalencia de la obesidad ha aumentado, sobre todo entre las mujeres. Objetivo: el objetivo de este estudio fue evaluar el efecto de una dieta hipoenergética combinada con harina de coco en los datos antropométricos y bioquímicos y, así como la calidad de la dieta. Métodos: se realizó un ensayo clínico cruzado que incluyó un paso solo con dieta hipoenergética y otro con la dieta asociada con el consumo de harina de coco (26 g) a lo largo de nueve meses. Los voluntarios fueron reclutados de la ciudad de São Gonçalo de Río de Janeiro. Antropométrica, datos bioquímicos y dietéticos fueron recolectados mensualmente. Fueron evaluados el índice de calidad de la dieta revisado para la población brasileña (ICD-R) y el consumo de alimentos y aditivos ultraprocesados. Se realizaron las pruebas de Wilcoxon y Mann-Whitney, con p < 0,05, considerado estadísticamente significativo. Resultados: participaron cuarenta y dos mujeres con un promedio de 47,5 ± 9,5 años de edad. La dieta hipoenergética promovió una disminución de la grasa corporal, el índice de masa corporal, la circunferencia de la cintura, la relación cintura-talla, el índice de adiposidad visceral, la presión arterial diastólica, los triglicéridos y VLDL. El consumo de harina de coco promovió una caída en los niveles de colesterol y glucosa totales al complementar la dieta hipoenergética. La mejora de la calidad de la dieta puede observarse en la disminución del consumo de alimentos ultraprocesados como el aceite vegetal, el chocolate y los refrescos. Conclusión: la dieta hipoenergética promovió una disminución en los parámetros antropométricos, la presión arterial y los triglicéridos. El consumo de harina de coco favoreció una disminución de los niveles de colesterol y de glucosa totales cuando se complementa la dieta hipoenergética. La calidad de la dieta mejorada se puede ver en la disminución del consumo de alimentos ultraprocesados.

  3. [Determination of folate content in ready-to-eat food products].

    PubMed

    Fajardo Martín, Violeta; Alonso-Aperte, Elena; Varela-Moreiras, Gregorio

    2013-01-01

    Introducción: Los productos ready-to-eat, ya cocinados, envasados y refrigerados, son cada vez más consumidos en nuestro país. Sin embargo, no existen estudios que cuantifiquen su disponibilidad comercial, composición e información detallada para poder estimar su impacto sobre las ingestas, particularmente de folatos, en los diferentes grupos de población. Objetivos: La finalidad de este trabajo de investigación ha consistido en conocer la disponibilidad actual de alimentos ready-to-eat de base vegetal y aportar datos sobre el contenido de folato total de los mismos. Métodos: La concentración de folato total se determinó en 17 productos precocinados refrigerados, con ingredientes vegetales, mediante el método microbiológico basado en el crecimiento del Lactobacillus casei subespecie rhamnosus resistente a cloranfenicol. La precisión del procedimiento analítico se comprobó mediante un material de referencia certificado y por una prueba de recuperación con ácido fólico tritiado. Resultados y discusión: El contenido medio de FT varió desde 13,6 hasta 103,8 μg/100 g de peso fresco, siendo superior en hamburguesas vegetales, recetas con garbanzos, guisantes o alcachofas con jamón. Los alimentos se sometieron al tratamiento térmico indicado por el fabricante previo a su consumo, observándose que no existen pérdidas de folatos durante este último procesado. El coeficiente de variación de los duplicados del mismo producto fue inferior al 15%. Conclusiones: Se presentan datos pioneros relativos al análisis de folatos en alimentos ready-to-eat en el mercado español, que ayudarán a evaluar la adecuación de la ingesta de folatos en la población. El contenido de folatos de estos productos, su facilidad de consumo y atractiva presentación, los convierte en fuentes potenciales de la vitamina.

  4. DESCRIPTION OF INDEXES BASED ON THE ADHERENCE TO THE MEDITERRANEAN DIETARY PATTERN: A REVIEW.

    PubMed

    Hernández-Ruiz, Angela; García-Villanova, Belén; Guerra Hernández, Eduardo J; Amiano, Pilar; Azpiri, Mikel; Molina-Montes, Esther

    2015-11-01

    Introducción: los índices de calidad la de dieta son herramientas que sirven para cuantificar el cumplimiento de un patrón dietético definido. Estos índices son una medida combinada de factores dietéticos (grupos alimenticios, alimentos, nutrientes y ratios) y/o estilos de vida. La dieta mediterránea (DM) es un patrón dietético que se caracteriza por sus efectos positivos contra ciertas enfermedades crónicas. Existen numerosos índices propuestos para la valoración de este patrón dietético. Es por lo tanto conveniente una evaluación de su composición y sus efectos sobre la salud. Objetivo: el objetivo es evaluar los índices de adhesión al patrón dietético mediterráneo en cuanto a su definición, aspectos metodológicos y validación en estudios epidemiológicos. Métodos: se buscaron en PubMed estudios que desarrollaron índices de DM hasta octubre de 2014. Resultados: se identificaron un total de 22 índices, con diferencias en cuanto al número de componentes (7-28), puntuación (0, 1, 2, 3, 4, 5, 8 o 10, en el caso de cumplimiento), rango (0-100) y tipo de componentes (grupos de alimentos/alimentos o su combinación con nutrientes). Entre los componentes positivos, los más comunes fueron frutas y verduras, y carnes entre los negativos. También hubo diferencias con respecto a su composición y evaluación (p. ej. criterios de consumo moderado de alcohol), así como con el sistema de puntuación (en medianas, terciles o raciones establecidas). Conclusiones: esta revisión sugiere que existe una gran heterogeneidad en la definición de DM. Sería por tanto apropiado establecer con mayor claridad los componentes que deben incluirse, así como definir criterios comunes para cuantificar este patrón dietético.

  5. [Food intake, nutritional status and physical activity between elderly with and without chronic constipation. A comparative study].

    PubMed

    Vargas-García, Elisa Joan; Vargas-Salado, Enrique

    2013-01-01

    antecedentes: el estreñimiento es uno de los trastornos gastrointestinales más comunes en la población de edad avanzada porque con el paso de los años los factores implicados en su causa se modifican y repercuten en la ingestión de alimentos, el estado de nutrición y la actividad física. Objetivo: evaluar en el adulto mayor el efecto en el estreñimiento crónico del consumo de alimentos con alto contenido de fibra, el estado nutricio, y la actividad física. Material y métodos: estudio comparativo, prospectivo y transversal efectuado en 140 adultos mayores de la consulta externa de la Unidad de Medicina Familiar51 del Instituto Mexicano del Seguro Social en la ciudad de León, Guanajuato, durante el periodo del 4 mayo al 30 de octubre de 2009. Se valoró si padecían o no estreñimiento de acuerdo con los criterios de Roma III. Se valoró: peso,talla, circunferencia del brazo, pliegue cutáneo tricipital; se aplicó un cuestionario de actividad física validado, y se obtuvo el registro dietético de tres días (dos de entre semana y uno de sábado o domingo). Resultados: la ingestión promedio de fibra y agua no esultó estadísticamente diferente entre los grupos estudiados. Los pacientes con estreñimiento tuvieron dietas menos completas y variadas (p < 0.02; p < 0.03). El estado nutricio predominante en los adultos mayores de ambos grupos fue de sobrepeso (p= 0.49) pero el grupo sin estreñimiento tuvo niveles más altos de actividad física en comparación con los estreñidos (1664 vs 1049 METs, p= 0.004).Conclusiones: el menor nivel de actividad física, la monotonía en la dieta, y no incluir todos los grupos de alimentos son factores que se asocian con el estreñimiento en el adulto mayor. De acuerdo con los resultados de este estudio la menor ingestión de fibra no se relacionó con el estreñimiento.

  6. Usefulness of dietary enrichment on energy and protein intake in elderly patients at risk of malnutrition discharged to home.

    PubMed

    Trabal, Joan; Hervas, Sonia; Forga, Maria; Leyes, Pere; Farran-Codina, Andreu

    2014-02-01

    Introducción: La desnutrición es causa de preocupación en muchos pacientes ingresados, siendo frecuente al ingreso y alta hospitalaria. Objetivos: El objetivo de este estudio fue valorar si el enriquecimiento de la dieta con pequeñas raciones de alimentos densos en energía y nutrientes mejora la ingesta energética y de nutrientes en pacientes ancianos con riesgo de desnutrición dados de alta al domicilio. Métodos: Estudio retrospectivo de una serie de casos en paciente ancianos con riesgo de desnutrición tratados con enriquecimiento de la dieta. Se revisaron los datos de la historia clínica y dietética de pacientes ancianos dados de alta a domicilio. Cuarenta-y-un pacientes, con una edad media de 83 ± 5 años, cumplieron los criterios de inclusión; 13 pacientes se perdieron después de 4 semanas de tratamiento y un total de 24 después de 12 semanas. El historial contenía datos de la ingesta de alimentos valorada a nivel basal, y después de 4 y 12 semanas de tratamiento. El Mini Nutritional Assessment, las medidas antropométricas, los parámetros bioquímicos rutinarios y el Índice de Barthel fueron valorados a nivel basal y después de 12 semanas. Resultados: En comparación al inicio, los pacientes mejoraron significativamente su ingesta energética y proteica después de 4 semanas de tratamiento, cumpliendo con los requerimientos nutricionales medios. La mejora en la ingesta de energía y proteínas todavía era manifiesta en la semana 12. Después de 12 semanas de enriquecimiento de la dieta, también se observó un incremento significativo en el peso (4.1%, p = 0.011). No se detectaron cambios significativos en el estado funcional. Conclusiones: El uso de pequeñas raciones de alimentos con elevada densidad energética y proteica para enriquecer las comidas parece ser un tratamiento nutricional factible para incrementar la ingesta energética y proteica y cumplir con los objetivos nutricionales en paciente ancianos dados de alta al domicilio.

  7. [Not Available].

    PubMed

    Higuera Pulgar, Isabel; Bretón Lesmes, Irene; Carrascal Fabián, María Luisa; Prieto García, Alicia; Menchén Viso, Luis; Nogales Rincón, Óscar; Iglesias Hernández, Natalia Covadonga; Issasa Rodríguez, Leire; García Peris, Pilar

    2016-01-01

    Introducción: la esofagitis eosinofílica (EEo) es una enfermedad inmunoalérgica crónica emergente en adultos. Surge como respuesta disfuncional frente a los antígenos de los alimentos y se caracteriza por síntomas recurrentes de disfunción esofágica e inflamación. El tratamiento farmacológico y dietético se basa en su patogénesis y debe ser individualizado. Uno de los posibles abordajes dietéticos se basa en la eliminación empírica de alimentos que con mayor frecuencia causan EEo.Objetivo: evaluar la ingesta dietética de los pacientes con EEo que siguen la dieta de exclusión de los seis grupos de alimentos (DESGA) y conocer sus posibles carencias nutricionales.Métodos: estudio transversal descriptivo en un grupo de pacientes con EEo que inició tratamiento con DESGA durante el periodo de marzo de 2013 hasta marzo de 2015. Se evaluó la ingesta mediante registro de 72 horas. Se compararon los resultados con las referencias para población adulta sana española (23). Para el análisis estadístico se usaron los test de Mann-Whitney, Krhuskall-Wallis y Chi-cuadrado. Significación p < 0,05.Resultados: se incluyeron en el estudio 14 pacientes. En algunos de ellos, la ingesta dietética siguiendo DESGA fue deficitaria en energía, proteínas y fibra. Tampoco consiguieron cubrir las ingestas de micronutrientes de calcio, zinc, magnesio, ácido fólico, niacina y vitaminas B2 y D, teniendo en cuenta edad y sexo, el 60% de la muestra.Conclusiones: el abordaje terapéutico mediante DESGA, teniendo en cuenta las características de la dieta, debe acompañarse de una evaluación periódica del estado nutricional, que incluya micronutrientes y una pauta de suplementación específica. PMID:27571662

  8. [Morphometric characteristics of the asterion and the posterolateral surface of the skull: its relationship with dural venous sinuses and its neurosurgical importance].

    PubMed

    Galindo-de León, Salvador; Hernández-Rodríguez, Alejandra Nohemí; Morales-Ávalos, Rodolfo; Theriot-Girón, María Del Carmen; Elizondo-Omaña, Rodrigo Enrique; Guzmán-López, Santos

    2013-01-01

    antecedentes: el conocimiento de la ubicación y características morfométricas del seno venoso lateral (transverso y sigmoides), así como de su relación con este y otros puntos de referencia anatómicos superficiales, es imprescindible durante los abordajes posterolaterales de la fosa craneal posterior para evitar lesionar las estructuras vasculares y las complicaciones quirúrgicas. Objetivo: determinar un área anatómica de seguridad para realizar un trépano que permita ingresar en la fosa craneal posterior sin lesionar estructuras adyacentes, y estudiar las características morfométricas del asterion, el seno lateral y puntos de referencia óseos de la superficie posterolateral del cráneo. Material y métodos: estudio observacional, transversal y descriptivo efectuado en el Departamento de Anatomía Humana de las Facultad de Medicina y de Odontología de la Universidad Autónoma de Nuevo León. Se analizaron 176 hemicráneos secos, estructuralmente íntegros y sin ninguna patología o anormalidad evidente. Se utilizó una broca de 1.3 mm de diámetro con la que se perforaron ambos lados de 88 cráneos secos (176 hemicráneos). Los puntos de referencia anatómicos estudiados fueron: asterion, vértice de la apófisis mastoides, espina suprameatal, plano horizontal de Frankfurt, raíz posterior del arco cigomático, protuberancia occipital externa y su relación con el seno venoso lateral. Resultados: el asterion tipo I prevalece en 74.4% de las piezas. En 82.4% de los cráneos el seno venoso lateral se encuentra a nivel del asterion inferior a éste en 12.5% y superior en 5.1%. Conclusiones: con los datos obtenidos de esta y otras investigaciones, el trépano inicial debe situarse 15 mm por debajo del asterion inferior y 15 mm posterior a éste para disminuir los riesgos de lesión del seno venoso lateral.

  9. Estimating harvested rainwater at greenhouses in south Portugal aquifer Campina de Faro for potential infiltration in Managed Aquifer Recharge.

    NASA Astrophysics Data System (ADS)

    Costa, Luís; Monteiro, José Paulo; Leitão, Teresa; Lobo-Ferreira, João Paulo; Oliveira, Manuel; Martins de Carvalho, José; Martins de Carvalho, Tiago; Agostinho, Rui

    2015-04-01

    The Campina de Faro (CF) aquifer system, located on the south coast of Portugal, is an important source of groundwater, mostly used for agriculture purposes. In some areas, this multi-layered aquifer is contaminated with high concentration of nitrates, possibly arising from excessive usage of fertilizers, reaching to values as high as 300 mg/L. In order to tackle this problem, Managed Aquifer Recharge (MAR) techniques are being applied at demonstration scale to improve groundwater quality through aquifer recharge, in both infiltration basins at the river bed of ephemeral river Rio Seco and existing traditional large diameter wells located in this aquifer. In order to assess the infiltration capacity of the existing infrastructures, in particular infiltration basins and large diameter wells at CF aquifer, infiltration tests were performed, indicating a high infiltration capacity of the existing infrastructures. Concerning the sources of water for recharge, harvested rainwater at greenhouses was identified in CF aquifer area as one of the main potential sources for aquifer recharge, once there is a large surface area occupied by these infrastructures at the demo site. This potential source of water could, in some cases, be redirected to the large diameter wells or to the infiltration basins at the riverbed of Rio Seco. Estimates of rainwater harvested at greenhouses were calculated based on a 32 year average rainfall model and on the location of the greenhouses and their surface areas, the latter based on aerial photograph. Potential estimated annual rainwater intercepted by greenhouses at CF aquifer accounts an average of 1.63 hm3/year. Nonetheless it is unlikely that the totality of this amount can be harvested, collected and redirected to aquifer recharge infrastructures, for several reasons, such as the lack of appropriate greenhouse infrastructures, conduits or a close location between greenhouses and large diameter wells and infiltration basins. Anyway, this

  10. Late Quaternary Offset of Alluvial Fan Surfaces along the Central Sierra Madre Fault, Southern California

    NASA Astrophysics Data System (ADS)

    Hanson, A.; Burgette, R. J.; Scharer, K. M.; Midttun, N. C.

    2015-12-01

    The Sierra Madre fault (SMF) is an east-west trending reverse fault system along the southern flank of the San Gabriel Mountains near Los Angeles, California. The ~140 km long SMF is separated into four segments, we focus on the multi-stranded, ~60 km long Central Sierra Madre fault (CSMF; W118.3-W117.7) as it lacks a well-characterized long-term geologic slip rate. We combine 1-m lidar DEM with geologic and geomorphic mapping to correlate alluvial fan surfaces along strike and across the fault strands in order to derive fault slip rates that cross the CSMF. We have refined mapping on two sets of terraces described by Crook et al. (1987) and references therein: a flight of Q3 surfaces (after nomenclature of Crook et al., 1987; McFadden, 1982) in Arroyo Seco with distinct terraces ~30 m, ~40 m, ~50 m, and ~55 m above the modern stream and in Pickens Canyon divided a Q3 and Q2 surface, with heights that are ~35 m and ~25 m above the modern stream respectively. Relative degree of clast weathering and soil development is consistent with geomorphic relationships; for example, hues of 7.5 YR to 10 YR are typical of Q3, while hues of 10 YR to 2.5 Y are typical of Q2. A scarp in the Q3 surface at Arroyo Seco has a vertical offset of ~16 m and a scarp in the Q3 at Pickens Canyon has a vertical offset of ~14 m, while the Q2 surface is not faulted. Our Quaternary dating strategy is focused on dating suites of terraces offset along CSMF scarps in order to provide broader stratigraphic context for the cosmogenic radionuclide and luminescence dating. We will present (pending) cosmogenic radionuclide depth profiles from the Q3 surfaces. A better-constrained slip rate for the CSMF will improve earthquake hazard assessment for the Los Angeles area and help clarify the tectonic role of the SMF in the broader plate boundary system. Additionally, the fan chronology will provide information about the timing of alluvial fan aggradation and incision in the western Transverse Ranges.

  11. Emergency Assessment of Postfire Debris-Flow Hazards for the 2009 Station Fire, San Gabriel Mountains, Southern California

    USGS Publications Warehouse

    Cannon, Susan H.; Gartner, Joseph E.; Rupert, Michael G.; Michael, John A.; Staley, Dennis M.; Worstell, Bruce B.

    2009-01-01

    This report presents an emergency assessment of potential debris-flow hazards from basins burned by the 2009 Station fire in Los Angeles County, southern California. Statistical-empirical models developed for postfire debris flows are used to estimate the probability and volume of debris-flow production from 678 drainage basins within the burned area and to generate maps of areas that may be inundated along the San Gabriel mountain front by the estimated volume of material. Debris-flow probabilities and volumes are estimated as combined functions of different measures of basin burned extent, gradient, and material properties in response to both a 3-hour-duration, 1-year-recurrence thunderstorm and to a 12-hour-duration, 2-year recurrence storm. Debris-flow inundation areas are mapped for scenarios where all sediment-retention basins are empty and where the basins are all completely full. This assessment provides critical information for issuing warnings, locating and designing mitigation measures, and planning evacuation timing and routes within the first two winters following the fire. Tributary basins that drain into Pacoima Canyon, Big Tujunga Canyon, Arroyo Seco, West Fork of the San Gabriel River, and Devils Canyon were identified as having probabilities of debris-flow occurrence greater than 80 percent, the potential to produce debris flows with volumes greater than 100,000 m3, and the highest Combined Relative Debris-Flow Hazard Ranking in response to both storms. The predicted high probability and large magnitude of the response to such short-recurrence storms indicates the potential for significant debris-flow impacts to any buildings, roads, bridges, culverts, and reservoirs located both within these drainages and downstream from the burned area. These areas will require appropriate debris-flow mitigation and warning efforts. Probabilities of debris-flow occurrence greater than 80 percent, debris-flow volumes between 10,000 and 100,000 m3, and high

  12. Vaccines in Argentina: a regulatory view.

    PubMed

    Pérez, A C; Diez, R A

    2003-07-28

    In Argentina, vaccines for immuno-preventable diseases are regulated by the national regulatory agency, the Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (the National Administration of Drugs, Food and Medical Devices, or ANMAT) created in 1992 to ensure efficacy and safety of drugs, food and medical devices available in the country, according to Law 16,463 and Decree 150/92. ANMAT has licensed 84 out of 157 vaccines registered in Argentina. Since 1994, ANMAT evaluated, approved and inspected 20 clinical trials with vaccines (1.8% of the 1062 trials approved by the agency since that time). The National System of Pharmaco-vigilance has received 318 communications of eventual adverse post-vaccination events (0.3% of the total). In addition, ANMAT provides support to the National Immunisation Programme. The current procedure is to follow international guidelines in the field, to be prepared for new, rapidly changing scenarios.

  13. [Sodium and potassium content of various Chilean foods].

    PubMed

    Alvarez de Araya, C; Farah, M; Zuccarelli, M T; Masson, L

    1981-03-01

    Sodium and potassium contents of 40 high-protein dietary products were determined in order to complete the Table de Composición Química se Alimentos Chilenos (Chemical Composition Table of Chilean Foods). These cations' level must be strictly controlled in diets of many renal and heart patients. In Chile, Nutritionists who are in charge of preparing these diets, do not have a national composition table related to the sodium and potassium content for most of the food products. Samples of fluid cow's milk, dried milk with different fat contents, some cheeses, hen eggs, bovine entrails, some meat derivates and several meat cuts, including bovine, pork, lamb and chicken were studied.

  14. Hyperimmune antirabies sera titration by standard mouse neutralization and counterimmunoelectrophoresis tests, comparing results of different laboratories.

    PubMed

    Díaz, A M; Valentini, E J; Albas, A; Fuches, R M; Gallina, N M

    1995-01-01

    To determine the rabies antibody level of twenty-four hyperimmune equine sera, Standard Mouse Neutralization (SMN) and Couterimmunoelectrophoresis (CIE) tests were carried out, both at the Instituto Butantan (IB) and Instituto Panamericano de Proteccíon de Alimentos y Zoonosis (INPPAZ). Statistical analysis has shown a correlation (r) of 0.9317 between the SMN and CIE performed at the IB, while at the INPPAZ it scored 0.974. Comparison of CIE data of both laboratories yielded a correlation of 0.845. The CIE technique has shown to be a sensitive and efficient as the SMN in titrating antirabies hyperimmune equine sera. Based on CIE results, a simple, rapid and inexpensive technique, titers of sera antibody can be rellably estimated in SMN test.

  15. Age group, menarche and regularity of menstrual cycles as efficiency predictors in the treatment of overweight.

    PubMed

    Kuzmar, Isaac; Cortés, Ernesto; Rizo, Mercedes

    2014-10-30

    Objetivo: Evaluar si existe una relacion entre los grupos de edad, la menarquia, ciclos menstruales y embarazos previos con el exito en la perdida de peso en pacientes obesos en una clinica de nutricion. Métodos: Se ha llevado a cabo un estudio entre pacientes con sobrepeso y obesidad que acudieron a una clinica de nutricion en la ciudad de Barranquilla (Colombia) con el fin de recibir un tratamiento nutricional. A todos los pacientes se les realizo un tratamiento nutricional semanal personalizado por 16 semanas continuas en los que se registraron los patrones de consumo de alimentos, medidas antropometricas, la imagen corporal y la auto-percepcion. Resultados: Se evaluaron un total de 135 pacientes. 41 (30,4%) de los cuales no completaron el estudio. 69,6% perdieron peso y 83,7% perdieron cintura. Estas perdidas son menores en edades mas avanzadas (95,5%

  16. Sodium intake may promote weight gain; results of the FANPE study in a representative sample of the adult Spanish population.

    PubMed

    Navia, Beatriz; Aparicio, Aránzazu; Perea, José Miguel; Pérez-Farinós, Napoleon; Villar-Villalba, Carmen; Labrado, Estefania; Ortega, Rosa María

    2014-06-01

    Introducción: Estudios recientes, han señalado que las dietas ricas en sodio podrían predisponer a la aparición de obesidad, ya sea de forma directa, o por estar asociadas con el consumo de alimentos que favorecen el aumento de peso. Objetivo: El objeto de este estudio fue analizar la asociación entre sodio urinario y presencia de sobrepeso y obesidad, en una muestra representativa de adultos españoles, así como conocer si el mayor consumo de sal, se asocia con unos peores hábitos alimentarios y con una mayor ingesta de alimentos, que puedan predisponer a la aparición de la misma. Métodos: Se ha estudiado un grupo de 418 adultos (196 hombres y 222 mujeres) de 18 a 60 años de edad. Se recogieron datos de peso, talla, circunferencia de cintura y se calculó, a partir de ellos, el IMC y el índice cintura/talla. Con el fin de conocer el consumo de alimentos, se aplicó un “Recuerdo de 24 horas” durante dos días consecutivos y se determinó el sodio en orina de 24 horas. Resultados: Un 34,4% de la población presentó sobrepeso y un 13,6% obesidad. Se observó una asociación positiva entre el IMC y la excreción urinaria de sodio. Los valores de sodio en orina también se relacionaron de forma directa con otros parámetros indicadores de adiposidad, como la circunferencia de la cintura o la relación cintura/talla. Tanto el peso, como el IMC, la circunferencia de la cintura y la relación cintura/talla, fueron mayores en el grupo con una excreción urinaria de sodio ≥154 mmol/l (Percentil 50) (P50). Además, las personas con una mayor eliminación urinaria de sodio presentaron una mayor ingesta calórica y un mayor consumo de alimentos totales y, en concreto, de carnes, precocinados y aperitivos. Tras ajustar por la ingesta de energía, la mayor ingesta de sodio resultó ser un factor de riesgo de tener un IMC más alto (OR = 1.0041, IC 95% 1.0015-1.0067, p < 0,01). Conclusiones: La ingesta de sal estuvo asociada con la presencia de obesidad, ya

  17. [In Process Citation].

    PubMed

    Calleja Fernández, Alicia; Vidal Casariego, Alfonso; Cano Rodríguez, Isidoro; Ballesteros Pomar, María D

    2016-03-25

    Introducción: la cuantificación y registro de la ingesta alimentaria del paciente hospitalizado es clave dentro del plan de cuidado nutricional. Objetivo: evaluar la validez de un cuestionario semicuantitativo de valoración del consumo comparado con una técnica de registro de alimentos por observación y pesada de los platos incluidos en la dieta hospitalaria. Métodos: estudio transversal realizado en condiciones de práctica clínica habitual. Las técnicas de valoración del consumo que se compararon fueron un registro por doble pesada y un cuestionario semicuantitativo por observación de la ingesta de cinco categorías (todo [> 80%], casi todo [80-60%], la mitad [60-40%], casi nada [40-20%] o nada [< 20%]), ambas realizadas por un dietista-nutricionista. La comparación entre ambas herramientas fue realizada con el índice kappa con ponderación cuadrática e intervalo de confianza del 95%. Resultados: fueron realizadas un total de 1.980 valoraciones. Se observó con el cuestionario semicuantitativo que en el 50% de los casos se ingirió todo, en el 19% casi todo, en el 13% la mitad, en el 9% menos de la mitad y en el 9% nada. La mediana de la ingesta por doble pesada de alimentos fue de 76,8 (RIC 45,8)%. Se observó que existió un acuerdo satisfactorio entre la técnica de doble pesada y la valoración visual del consumo con un valor κ = 0,907 (IC 95% 0,894-0,925). Conclusión: la escala visual empleada en este estudio permite cuantificar la ingesta real del paciente de forma precisa y adecuada por personal cualificado.

  18. [Information perceived by consumers through food labeling on fats: a systematic review].

    PubMed

    Sebastian-Ponce, Miren Itxaso; Sanz-Valero, Javier; Wanden-Berghe, Carmina

    2014-11-22

    Objetivo: Revisar la literatura científica relacionada con la información que reciben los consumidores sobre los distintos tipos de grasas de los alimentos a través del etiquetado. Método: Revisión sistemática de la documentación obtenida en las bases de datos MEDLINE (via PubMed), EMBASE, CINAHL, FSTA, Web of Science, Cochrane Library, SCOPUS y LILACS; hasta septiembre 2013. Los términos utilizados, como descriptores y texto libre, fueron: «dietary fats», «dietary fats, unsaturated» y «food labeling». Se utilizó el límite «humanos». Resultados: Se recuperaron 549 referencias, de las que se seleccionaron 36 artículos tras aplicar los criterios de inclusión y exclusión. Los principales efectos relacionados con la información del etiquetado estuvieron relacionados con el precio y lugar de compra/consumo, las dimensiones sensoriales, los hábitos dietéticos, la interpretación de logotipos y la educación. Conclusiones: El etiquetado sobre el contenido de grasa en los alimentos es una buena ayuda a la hora de tomar decisiones de consumo. La educación nutricional y de los significados de las etiquetas es fundamental y se mostró efectiva aunque no se haya logrado el “consumidor informado”. Se deberían dirigir las acciones formativas hacia las creencias y actitudes anteriores de los consumidores para hacer coherente el mensaje de salud y alimentación. Las etiquetas deberían ser homogéneas y reales a la hora de expresar composición o exponer logotipos. Los mensajes incluidos en el empaquetado deben ser claros y no inducir a engaño.

  19. [Food consumption in and around the school].

    PubMed

    Alvear-Galindo, M Guadalupe; Yamamoto-Kimura, Liria T; Morán-Álvarez, Cristina; Solís-Días, M Guadalupe; Torres-Durán, Patricia Victoria; Juárez-Oropeza, Marco Antonio; Acuña-Sánchez, M Eugenia; Ferreira-Hermosillo, Aldo

    2013-01-01

    Introducción: en México, los niños de primaria permanecen aproximadamente 4.5 horas en la escuela, por lo que fuera de ese espacio es donde consumen la mayor parte de sus alimentos. El objetivo de esta investigación fue explorar las conductas alimentarias más allá del entorno escolar que pudieran favorecer la obesidad. Métodos: estudio descriptivo de niños de una escuela primaria oficial en el Distrito Federal. Los hábitos alimentarios se conocieron por un cuestionario y las características antropométricas, por medición física. Resultados: los participantes indicaron consumir refrescos y jugos enlatados con alta frecuencia y en cantidades importantes (80 %), así como productos lácteos industrializados con alto valor calórico y bajo contenido de proteínas; ingerían pocos alimentos de origen animal; 30 % comía cuatro o cinco veces al día y 10 %, una o dos veces. Los resultados se asociaron con las características omatométricas de los niños, 37.6 % de los cuales presentó sobrepeso u obesidad y 12 %, bajo peso. Conclusiones: para la prevención de la obesidad son necesarios programas de educación que involucren a profesores, padres de familia y escolares, para obtener conductas saludables y preservar la salud.

  20. [CONSUMPTION OF OMEGA- 3 FATTY ACIDS AND DEPRESSIVE SYMPTOMS IN COLLEGE STUDENTS FROM SONORA, MEXICO].

    PubMed

    Rubi Vargas, María; González Lomelí, Daniel; Terrazas Medina, Efraín A; Peralta Peña, Sandra L; Jordán Jinez, Ma Lourdes; Ruiz Paloalto, Ma Laura; Cupul Uicab, Lea A

    2015-10-01

    Introducción: estudios recientes sugieren que los niveles bajos de acidos grasos poliinsaturados omega-3 se relacionan con una mayor prevalencia de depresion; sin embargo, los resultados no son concluyentes. Objetivo: evaluar la asociacion entre el bajo consumo de acidos grasos omega-3 y la presencia de sintomas depresivos en jovenes universitarios del noroeste de Mexico. Métodos: se realizo un estudio transversal en una muestra de 706 universitarios de 18 a 24 anos de edad de ambos sexos. La presencia de sintomatologia depresiva se estimo con la escala de Depresion del Centro de Estudios Epidemiologicos (CES-D) empleando un punto de corte ≥ 24. El consumo semanal de acidos grasos alfalinolenico (ALA) y de eicosapentaenoico (EPA) mas docosahexaenoico (DHA) en mg/g de alimento se estimo por medio de un cuestionario de frecuencia de consumo de alimentos validado para la poblacion mexicana. La asociacion del consumo de omega-3 con la presencia de sintomas depresivos se evaluo con modelos de regresion logistica. Resultados: el 67% de los participantes fueron mujeres; en general, el 16,6% presentaron sintomatologia depresiva. El consumo bajo de ALA y EPA + DHA no se asocio con mayor prevalencia de sintomatologia depresiva antes y despues de ajustar por confusores. En aquellos casos con sintomatologia depresiva, los niveles ALA derivados solo de las nueces fueron significativamente menores. Conclusiones: en esta poblacion no se observo asociacion entre el bajo consumo de acidos grasos omega-3 y la sintomatologia depresiva. La posible asociacion entre el consumo de nueces y la sintomatologia depresiva requiere de mas estudios.

  1. [Association between food behavior and hypercholesterolemia-LDL in university students].

    PubMed

    Salazar Ruiz, Erika Nohemi; Márquez Sandoval, Yolanda Fabiola; Vizmanos Lamotte, Bárbara; Altamirano Martínez, Martha Betzaida; Salgado Bernabé, Aralia Berenice; Salgado Goytia, Lorenzo; Muñoz Valle, José Francisco; Parra Rojas, Isela

    2015-06-01

    Introducción: la hipercolesterolemia-LDL (H-LDL) se asocia a mayor riesgo de enfermedad cardiovascular. La asociacion entre H-LDL y alimentacion se ha centrado en aspectos nutrimentales. El estudio de la asociacion entre el comportamiento alimentario (CA) y la H-LDL en estudiantes universitarios podria brindar elementos de correccion y/o prevencion nutricional en esta poblacion. Objetivo: evaluar la asociacion entre CA e H-LDL en estudiantes universitarios. Métodos: estudio transversal realizado en una muestra de 167 estudiantes de la Universidad Autonoma de Guerrero, Mexico. Se midio el colesterol-LDL serico, considerandose hipercolesterolemia una concentracion ≥100 mg/dL. El CA se evaluo mediante un cuestionario previamente validado. La asociacion entre CA e H-LDL se determino con una regresion logistica bivariada, ajustando por sexo, edad, nivel socioeconomico, tabaquismo, ingesta de energia, actividad fisica, presencia o no de obesidad y antecedentes familiares. Resultados: consumir el almuerzo (colacion matutina) se asocio con un 63% de menos riesgo de H-LDL (OR 0,37; 95% IC 0,15, 0,90). Ingerir alimentos fuera de casa una o dos veces a la semana, se asocio con cuatro veces mas riesgo de H-LDL (R 5,14; 95% IC 1,12, 23,62). Los sujetos que referian consumir alimentos en exceso (1 o 2, y 3 o mas veces/semana) tuvieron mayor riesgo de H-LDL (OR 3,26; 95% IC 1,10, 9,64 y OR 10,52; 95% IC 2,66, 41,60, respectivamente). Conclusiones: algunos CA habituales de los estudiantes universitarios de Guerrero implican mayor riesgo de H-LDL. Por ello, promover acciones correctivas y/o preventivas centradas en estos CA podria mejorar la salud de esta poblacion.

  2. Availability of food stores and consumption of fruit, legumes and vegetables in a Brazilian urban area.

    PubMed

    Cristine Pessoa, Milene; Loures Mendes, Larissa; Teixeira Caiaffa, Waleska; Carvalho Malta, Deborah; Velásquez-Meléndez, Gustavo

    2014-12-17

    Antecedentes: El ambiente alimentar puede tener una influencia importante en la disponibilidad y el acceso a ellos, éste desempeña un papel importante en la salud de las poblaciones. El objetivo de este estudio fue comparar el consumo de frutas, legumbres y hortalizas (FLV) de adultos y la disponibilidad de las tiendas de alimentos en el contexto del espacio socioeconómico y geográfico en el territorio de las unidades básicas de salud en una capital brasileña. Métodos: El estudio se desarrolló a partir de la información obtenida a través de la Vigilancia de Factores de Riesgo para Enfermedades no Transmisibles Prevención de Encuesta Telefónica (VIGITEL), utilizando muestras de la ciudad de Belo Horizonte en los años de 2008 a 2010. Un total de 5.611 registros fueron geo-codificados usando el código postal. Una puntuación fue creada en base a la frecuencia semanal y diario del consumo de FLV . El área de las unidades básicas de salud se utilizó como unidad vecinal. Se utilizaron los datos geo-referenciados de los comercios de venta de comida en la ciudad y el barrio. Resultados: A medida que aumentaba la renta del barrio, hubo un aumento en la distribución de los establecimientos de comida e bebidas para todas las categorías estudiadas. Se observaron las puntuaciones más altas de consumo FLV en zonas con niveles de ingresos más altos. Conclusión: La mayor concentración de tiendas de alimentos e bebidas e mayor puntuación de consumo, independientemente da calidad de los productos ofrecidos, fue observado en las áreas geográficas con mayor poder adquisitivo.

  3. [Not Available].

    PubMed

    San Mauro Martin, Ismael; Mendive Dubourdieu, Paula; Paredes Barato, Víctor; Garicano Vilar, Elena

    2016-07-19

    Introducción: la tradición de la comida picante desempeña un papel muy importante en el gusto por este tipo de comida y su tolerancia. Las preferencias alimentarias muestran influencia genética y ambiental.Objetivos: estudiar la tolerancia y el gusto por el picante de tres poblaciones, y la influencia hereditaria y del ambiente.Métodos:se realizó una encuesta a 522 sujetos, de tres continentes (Asia, Europa y Latinoamérica) en tres idiomas (español, inglés y chino) a través de Internet. Se realizaron preguntas acerca de la tolerancia al picante, el gusto por los alimentos picantes, su uso, la edad de comienzo de consumo, el gusto del padre y de la madre y si ella lo consumía durante el embarazo y/o lactancia.Resultados: existe diferencia entre el gusto por el picante del hijo y el sexo (p < 0,001), la tolerancia (p < 0,001) y, solo en el sexo femenino, el gusto de la madre por el picante (p < 0,001), su consumo durante el embarazo (p < 0,001) y la lactancia (p = 0,005) y el gusto del padre por el picante (p = 0,003). Existe correlación entre el continente de residencia (p = 0,007) y de nacimiento (p = 0,012) y la tolerancia a los alimentos picantes.Conclusión: la influencia de los progenitores, el género y la composición corporal se relacionaron con gustos y tolerancias diferentes.

  4. [Not Available].

    PubMed

    San Mauro Martin, Ismael; Mendive Dubourdieu, Paula; Paredes Barato, Víctor; Garicano Vilar, Elena

    2016-01-01

    Introducción: la tradición de la comida picante desempeña un papel muy importante en el gusto por este tipo de comida y su tolerancia. Las preferencias alimentarias muestran influencia genética y ambiental.Objetivos: estudiar la tolerancia y el gusto por el picante de tres poblaciones, y la influencia hereditaria y del ambiente.Métodos:se realizó una encuesta a 522 sujetos, de tres continentes (Asia, Europa y Latinoamérica) en tres idiomas (español, inglés y chino) a través de Internet. Se realizaron preguntas acerca de la tolerancia al picante, el gusto por los alimentos picantes, su uso, la edad de comienzo de consumo, el gusto del padre y de la madre y si ella lo consumía durante el embarazo y/o lactancia.Resultados: existe diferencia entre el gusto por el picante del hijo y el sexo (p < 0,001), la tolerancia (p < 0,001) y, solo en el sexo femenino, el gusto de la madre por el picante (p < 0,001), su consumo durante el embarazo (p < 0,001) y la lactancia (p = 0,005) y el gusto del padre por el picante (p = 0,003). Existe correlación entre el continente de residencia (p = 0,007) y de nacimiento (p = 0,012) y la tolerancia a los alimentos picantes.Conclusión: la influencia de los progenitores, el género y la composición corporal se relacionaron con gustos y tolerancias diferentes. PMID:27571668

  5. Eating habits, nutritional status and quality of life of patients in late postoperative gastric bypass Roux-Y.

    PubMed

    Prazeres de Assis, Priscila; Alves da Silva, Silvia; Sousa Vieira de Melo, Camila Yandara; de Arruda Moreira, Marcella

    2013-01-01

    Objetivo: Caracterizar los hábitos alimenticios, el estado nutricional y la calidad de vida de pacientes en el periodo posoperatorio de la cirugía bariátrica de Fobi-Capella. Métodos: Se realizó un estudio analítico transversal en 66 pacientes sometidos a cirugía bariátrica y monitorizados por el personal del Hospital Universitario Oswaldo Cruz (HUOC), en el noreste de Brasil. Se aplicó un cuestionario que contemplaba características sociodemográficas e información demográfica relativa a los hábitos alimenticios, y también se evaluaba la calidad de vida por el método BAROS. Resultados: En la tolerancia a los alimentos, en la categoría de «difícil de comer» se notificaron alimentos tales como carne, pollo, arroz, ensalada cruda y maíz y en la «no ingeridos» estaban maíz, seguido de caramelos, carne y pollo. Hubo una reducción del peso corporal total y del IMC y, en consecuencia, un aumento del PEP% con el tiempo. Con respecto a la calidad de vida, se pudo observar que la mayor parte de los pacientes la clasificaron como «buena» en ambos grupos de 6-18 meses y de > 18 meses. Conclusiones: Nuestro resultados demuestran que la cirugía bariátrica produjo unos efectos satisfactorios en esta población; sin embargo, existe la necesidad de una educación nutricional continuada, especialmente en el grupo de más de 18 meses tras la cirugía.

  6. [Nutrition and cancer].

    PubMed

    Hernando Requejo, Ovidio; Rubio Rodríguez, Ma Carmen

    2015-07-18

    Introducción: hoy día se conoce cómo la dieta juega un importante papel tanto en la producción como en la prevención del cáncer. Métodos: se ha realizado una completa revisión bibliográfica para intentar conocer mejor aquellas dietas que pueden ser protectoras contra el cáncer o aquellas con más riesgo de producir cáncer. Resultados: entre los alimentos que pueden proteger de la aparición del cáncer destacan las frutas y verduras, también la soja y sus derivados y los pescados han mostrado protección frente a algunos tipos de tumores. Como claros factores que aumentan el riesgo de cáncer caben destacar la carne roja o procesada, los lácteos y el alcohol. El papel protector de vitaminas, antioxidantes y otros micronutrientes ha de ser explorado más a fondo. La obesidad parece un factor etiológico claro, asimismo la restricción calórica podría, de forma antagónica a la obesidad, proteger contra la aparición de tumores en estudios de laboratorio, pero se requerirán estudios clínicos para validar esta hipótesis. Conclusiones: el control de la dieta y la selección adecuada de los alimentos sería un método muy útil y de bajo coste en la prevención de tumores.

  7. [Capacity analysis of health food choice by reference to consumers in two models of nutritional labeling; crossover study].

    PubMed

    Babio, Nancy; López, Leonor; Salas-Salvadó, Jordi

    2013-01-01

    Introducción: El objetivo del presente estudio fue comparar dos modelos de etiquetado nutricional en la parte frontal del envase alimentario, en referencia a la capacidad de los consumidores de realizar elecciones alimentarias más cercanas a las recomendaciones nutricionales. Métodos: Se realizó un estudio aleatorizado cruzado en 32 adultos (18 a 65 años) de ambos sexos. Los participantes fueron aleatorizados a realizar dos condiciones experimentales utilizando el sistema semáforo nutricional (SSN) o el sistema monocromo (S-M), en las que debían escoger sus elecciones de alimentos dentro de un menú cerrado según la información del etiquetado nutricional. Para cada alimento, el participante tenía tres opciones con diferente composición nutricional. Se calculó el promedio de energía, grasa total y saturada, azúcar y sal a partir de las opciones elegidas por cada participante. Resultados: No se observaron diferencias significativas con respecto a sexo, edad, IMC ni nivel socioeconómico en función del orden de inicio de la condición experimental. Los sujetos tendieron a escoger una dieta con un menor, pero no significativo contenido en energía de 23,0 ± 67,5 kcal (P = 0,063) y un significativo menor contenido en azúcares de 3,5 ± 9,2 g; P < 0.001 y de 0,6 ± 1 g; P < 0,003 en sal. Conclusiones: En comparación con el sistema monocromo, el sistema del semáforo nutricional puede ayudar probablemente a realizar elecciones alimentarias con menor cantidad en azúcares y sal en una situación similar a la habitual de compra en la que existe una limitación de tiempo.

  8. [Nutritional characteristics of school lunch menus in Biscay (Basque Country, Spain) in 2012/2013].

    PubMed

    Sancho Uriarte, Patricia; Cirarda Larrea, Francisco Borja; Valcárcel Alonso, Santiago

    2014-09-28

    Introducción: Uno de los elementos abordados desde la Estrategia para la Nutrición, Actividad física y prevención de la Obesidad y Salud (NAOS) es la alimentación en el medio escolar. Objetivo: Evaluar, tomando como referencia el conjunto mínimo de indicadores y recomendaciones de la Estrategia NAOS, una muestra de menús distribuidos en varios comedores escolares de Bizkaia. Métodos: Estudio descriptivo transversal basado en la revisión teórica de los menús basales distribuidos por siete cocinas centrales que abastecen a 324 centros escolares (80.969 alumnos). Se determinó y valoró la frecuencia semanal de varios grupos de alimentos; los documentos de referencia fueron “Evaluación y Seguimiento de la Estrategia NAOS: Conjunto de Indicadores” y las recomendaciones del “Documento de Consenso sobre la alimentación en los centros educativos”. Resultados y discusión: El 100% de los comedores cumple con los mínimos relativos a legumbres, pescados y precocinados y con las recomendaciones relativas a carne y productos cárnicos. Si bien se aproximan bastante, ninguno cumple con los mínimos de fruta, verdura o con la información nutricional complementaria. Se han evidenciado diferencias entre las recomendaciones de La Estrategia NAOS y las condiciones exigidas por el Departamento de Educación, así como dificultades en la cuantificación y clasificación de varios alimentos. Conclusiones: Se recomienda incrementar el contenido en frutas, verduras, huevos y pescado azul de los menús escolares, así como ofrecer a las familias una información de los menús más detallada.

  9. Persistent Contamination of Octopuses and Mussels with Lipophilic Shellfish Toxins during Spring Dinophysis Blooms in a Subtropical Estuary

    PubMed Central

    Mafra, Luiz L.; Lopes, Daiana; Bonilauri, Vanessa C.; Uchida, Hajime; Suzuki, Toshiyuki

    2015-01-01

    This study investigates the occurrence of diarrhetic shellfish toxins (DSTs) and their producing phytoplankton species in southern Brazil, as well as the potential for toxin accumulation in co-occurring mussels (Perna perna) and octopuses (Octopus vulgaris). During the spring in 2012 and 2013, cells of Dinophysis acuminata complex were always present, sometimes at relatively high abundances (max. 1143 cells L−1), likely the main source of okadaic acid (OA) in the plankton (max. 34 ng L−1). Dinophysis caudata occurred at lower cell densities in 2013 when the lipophilic toxins pectenotoxin-2 (PTX-2) and PTX-2 seco acid were detected in plankton and mussel samples. Here, we report for the first time the accumulation of DSTs in octopuses, probably linked to the consumption of contaminated bivalves. Perna perna mussels were consistently contaminated with different DSTs (max. 42 µg kg−1), and all octopuses analyzed (n = 5) accumulated OA in different organs/tissues: digestive glands (DGs) > arms > gills > kidneys > stomach + intestine. Additionally, similar concentrations of 7-O-palmytoyl OA and 7-O-palmytoly dinophysistoxin-1 (DTX-1) were frequently detected in the hepatopancreas of P. perna and DGs of O. vulgaris. Therefore, octopuses can be considered a potential vector of DSTs to both humans and top predators such as marine mammals. PMID:26096277

  10. Persistent Contamination of Octopuses and Mussels with Lipophilic Shellfish Toxins during Spring Dinophysis Blooms in a Subtropical Estuary.

    PubMed

    Mafra, Luiz L; Lopes, Daiana; Bonilauri, Vanessa C; Uchida, Hajime; Suzuki, Toshiyuki

    2015-06-18

    This study investigates the occurrence of diarrhetic shellfish toxins (DSTs) and their producing phytoplankton species in southern Brazil, as well as the potential for toxin accumulation in co-occurring mussels (Perna perna) and octopuses (Octopus vulgaris). During the spring in 2012 and 2013, cells of Dinophysis acuminata complex were always present, sometimes at relatively high abundances (max. 1143 cells L-1), likely the main source of okadaic acid (OA) in the plankton (max. 34 ng L-1). Dinophysis caudata occurred at lower cell densities in 2013 when the lipophilic toxins pectenotoxin-2 (PTX-2) and PTX-2 seco acid were detected in plankton and mussel samples. Here, we report for the first time the accumulation of DSTs in octopuses, probably linked to the consumption of contaminated bivalves. Perna perna mussels were consistently contaminated with different DSTs (max. 42 µg kg-1), and all octopuses analyzed (n = 5) accumulated OA in different organs/tissues: digestive glands (DGs) > arms > gills > kidneys > stomach + intestine. Additionally, similar concentrations of 7-O-palmytoyl OA and 7-O-palmytoly dinophysistoxin-1 (DTX-1) were frequently detected in the hepatopancreas of P. perna and DGs of O. vulgaris. Therefore, octopuses can be considered a potential vector of DSTs to both humans and top predators such as marine mammals.

  11. Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.

    PubMed

    Yu, Heng-Yi; Chen, Zu-Yu; Sun, Bin; Liu, Junjun; Meng, Fan-Yu; Liu, Ye; Tian, Tian; Jin, An; Ruan, Han-Li

    2014-06-27

    Two rare 7,8-seco-lignans (1, 2), three new lignan glycosides (3, 4a, 4b), and 10 known lignans (5-14) were isolated from the fruit of Schisandra glaucescens Diels. The absolute configurations of 1 and 2 were determined by comparing their experimental and calculated electronic circular dichroism spectra. The molecular structures of the new compounds (3, 4a, and 4b), including their absolute configurations, were determined using various spectroscopic methods and hydrolysis reactions. The antioxidant activities of the isolated compounds were tested using 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assays. Compounds 4, 7, 8, 10, 11, and 12 exhibited antioxidant activities of varying potential in both assays. Of these compounds, 7 showed the strongest 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity, with IC50 values of 15.7 (150 μM DPPH) and 34.6 μM (300 μM DPPH), respectively, and 4, 12, and 7 displayed higher total antioxidant activities than Trolox in the ferric reducing antioxidant power assay. The neuroprotective effects of these compounds against Aβ25-35-induced cell death in SH-SY5Y cells were also investigated. Compounds 1, 2, 6, 7, 8, 11, and 12 exhibited statistically significant neuroprotective effects against Aβ25-35-induced SH-SY5Y cell death compared with the group treated only with Aβ25-35.

  12. Acetylcholine suppression and potential benefit against anticholinesterase poisoning. Annual report No. 2, 1 July 1983-30 June 1984

    SciTech Connect

    O'Neill, J.J.; Doukas, H.; Sterling, H.

    1984-07-01

    A new series of compounds containing the quinuclidine moiety has been synthesized and tested as inhibitors of brain choline acetyltransferase (ChAT) or as inhibitors of high affinity choline uptake (HAChU). The tertiary quinuclidine was incorporated because of the potency it confers on anticholinergic compounds and antimuscarinic drugs, such as quinuclidinylbenzilate (QNB). Structure-activity studies indicate that ChAT inhibition and lipophilicity show a direct correlation and that some of the structure-activity relationships previously proposed (2) need to be modified to fit new insights gained from studies with the brain ChAT. The effectiveness of the quaternary HAChU inhibitor, acetylseco-hemicholinium (AcSeco HC) to block choline uptake and interfere with acetylcholine (ACh) synthesis served as a basis for in vivo protection studies versus soman. As an adjunct to atropine and oxime, the results obtained point to the need for HAChU inhibitors with pharmacokinetic properties which will permit oral or parenteral administration leading to high central nervous system (CNS) penetration. Based on initial in vitro studies, several quinuclidine derivatives show activity in brain nerve ending preparations. A series of toxicity studies has established the LD50 dose of soman at 1 hr and 24 hours. Based on the most potent inhibitors of ChAT activity, we have selected a series of tertiary amines as adjuncts to atropine-oxime therapy to ascertain whether such combinations increase protection against soman.

  13. Delineation of Steroid-Degrading Microorganisms through Comparative Genomic Analysis

    PubMed Central

    Bergstrand, Lee H.; Cardenas, Erick; Holert, Johannes; Van Hamme, Jonathan D.

    2016-01-01

    ABSTRACT Steroids are ubiquitous in natural environments and are a significant growth substrate for microorganisms. Microbial steroid metabolism is also important for some pathogens and for biotechnical applications. This study delineated the distribution of aerobic steroid catabolism pathways among over 8,000 microorganisms whose genomes are available in the NCBI RefSeq database. Combined analysis of bacterial, archaeal, and fungal genomes with both hidden Markov models and reciprocal BLAST identified 265 putative steroid degraders within only Actinobacteria and Proteobacteria, which mainly originated from soil, eukaryotic host, and aquatic environments. These bacteria include members of 17 genera not previously known to contain steroid degraders. A pathway for cholesterol degradation was conserved in many actinobacterial genera, particularly in members of the Corynebacterineae, and a pathway for cholate degradation was conserved in members of the genus Rhodococcus. A pathway for testosterone and, sometimes, cholate degradation had a patchy distribution among Proteobacteria. The steroid degradation genes tended to occur within large gene clusters. Growth experiments confirmed bioinformatic predictions of steroid metabolism capacity in nine bacterial strains. The results indicate there was a single ancestral 9,10-seco-steroid degradation pathway. Gene duplication, likely in a progenitor of Rhodococcus, later gave rise to a cholate degradation pathway. Proteobacteria and additional Actinobacteria subsequently obtained a cholate degradation pathway via horizontal gene transfer, in some cases facilitated by plasmids. Catabolism of steroids appears to be an important component of the ecological niches of broad groups of Actinobacteria and individual species of Proteobacteria. PMID:26956583

  14. Tectonic setting of basic igneous and metaigneous rocks of Borborema Province, Brazil using multi-dimensional geochemical discrimination diagrams

    NASA Astrophysics Data System (ADS)

    Verma, Sanjeet K.; Oliveira, Elson P.

    2015-03-01

    Fifteen multi-dimensional diagrams for basic and ultrabasic rocks, based on log-ratio transformations, were used to infer tectonic setting for eight case studies of Borborema Province, NE Brazil. The applications of these diagrams indicated the following results: (1) a mid-ocean ridge setting for Forquilha eclogites (Central Ceará domain) during the Mesoproterozoic; (2) an oceanic plateau setting for Algodões amphibolites (Central Ceará domain) during the Paleoproterozoic; (3) an island arc setting for Brejo Seco amphibolites (Riacho do Pontal belt) during the Proterozoic; (4) an island arc to mid-ocean ridge setting for greenschists of the Monte Orebe Complex (Riacho do Pontal belt) during the Neoproterozoic; (5) within-plate (continental) setting for Vaza Barris domain mafic rocks (Sergipano belt) during the Neoproterozoic; (6) a less precise arc to continental rift for the Gentileza unit metadiorite/gabbro (Sergipano belt) during the Neoproterozoic; (7) an island arc setting for the Novo Gosto unit metabasalts (Sergipano belt) during Neoproterozoic; (8) continental rift setting for Rio Grande do Norte basic rocks during Miocene.

  15. A water-resources data network evaluation for Monterey County, California; Phase 1; South county

    USGS Publications Warehouse

    Showalter, P.K.; Hord, S.H.

    1986-01-01

    An evaluation made of rainfall, surface water, groundwater, and water quality monitoring networks in Salinas River basin in southern Monterey County, California, proposed all long-term rain gages be continued for extending short-term records and suggested the installation of two additional recording gages. Eight new storage rain gages were suggested at midaltitudes of east and west sides of Salinas Valley where few data are available. The evaluation revealed some short-term gaging stations could be discontinued because of good regression relations between them and the long-term stations Arroyo Seco near Soledad. Of 16 stations selected for the proposed network, 4 are new recording stations, 6 are new nonrecording streamflow and water quality sampling sites, 5 are existing stations, and the last is a station operated from 1969 to 1976; also included are water quality sampling stations on Lakes Nacimiento and San Antonio. The proposed groundwater network was developed from information on geology, geohydrology, and groundwater quality, high priority objectives for groundwater network, and consideration for providing good areal coverage of levels and water quality. Of 145 sites selected, 86 are existing monitoring wells. (USGS)

  16. Molecular structure and vibrational bands and 13C chemical shift assignments of both enmein-type diterpenoids by DFT study

    NASA Astrophysics Data System (ADS)

    Wang, Tao; Wu, Yi fang; Wang, Xue liang

    2014-01-01

    We report here theoretical and experimental studies on the molecular structure and vibrational and NMR spectra of both natural enmein type diterpenoids molecule (6, 7-seco-ent-kaurenes enmein type), isolated from the leaves of Isodon japonica (Burm.f.) Hara var. galaucocalyx (maxin) Hara. The optimized geometry, total energy, NMR chemical shifts and vibrational wavenumbers of epinodosinol and epinodosin have been determined using B3LYP method with 6-311G (d,p) basis set. A complete vibrational assignment is provided for the observed IR spectra of studied compounds. The calculated wavenumbers and 13C c.s. are in an excellent agreement with the experimental values. Quantum chemical calculations at the B3LYP/6-311G (d,p) level of theory have been carried out on studied compounds to obtain a set of molecular electronic properties (MEP,HOMO, LUMO and gap energies ΔEg). Electrostatic potential surfaces have been mapped over the electron density isosurfaces to obtain information about the size, shape, charge density distribution and chemical reactivity of the molecules.

  17. Sesquiterpenes from Neurolaena lobata and Their Antiproliferative and Anti-inflammatory Activities

    PubMed Central

    2014-01-01

    Five new sesquiterpenes, neurolobatin A (1), neurolobatin B (2), 5β-hydroxy-8β-isovaleroyloxy-9α-hydroxycalyculatolide (3), 3-epi-desacetylisovaleroylheliangine (4), and 3β-acetoxy-8β-isovaleroyloxyreynosin (5), were isolated from the aerial parts of Neurolaena lobata. The structures were established by means of a combined spectroscopic data analysis, including ESIMS, APCI-MS, and 1D- and 2D-NMR techniques. Neurolobatin A (1) and B (2) are unusual isomeric seco-germacranolide sesquiterpenes with a bicyclic acetal moiety, compounds 3 and 4 are unsaturated epoxy-germacranolide esters, and compound 5 is the first eudesmanolide isolated from the genus Neurolaena. The isolated compounds (1–5) were shown to have noteworthy antiproliferative activities against human tumor cell lines (A2780, A431, HeLa, and MCF7). The anti-inflammatory effects of 1–5, evaluated in vitro using LPS- and TNF-α-induced IL-8 expression inhibitory assays, revealed that all these compounds strongly down-regulated the LPS-induced production of IL-8 protein, with neurolobatin B (2) and 3-epi-desacetylisovaleroylheliangine (4) being the most effective. PMID:24476550

  18. Secondary metabolites from marine-derived Streptomyces antibioticus strain H74-21.

    PubMed

    Fu, Shuna; Wang, Fan; Li, Hongyu; Bao, Yixuan; Yang, Yu; Shen, Huifang; Lin, Birun; Zhou, Guangxiong

    2016-11-01

    A new secondary metabolite, (2S,3R)-l-threonine, N-[3-(formylamino)-2-hydroxybenzoyl]-ethyl ester (streptomyceamide C, 1), together with four known compounds 1, 4-dimethyl-3-isopropyl-2,5-piperidinedione (2), cyclo-((S)-Pro-8- hydroxy-(R)-Ile (3), cyclo-((S)-Pro-(R)-Leu (4), and seco-((S)-Pro-(R)-Val) (5), were isolated from the EtOH extract of the fermented mycelium of the marine-derived streptomycete strain H74-21, which was isolated from sea sediment in a mangrove site. The structure of the new compound was established on the basis of its spectroscopic data, including 1D and 2D NMR, HR-TOF-MS. Their antifungal activities against Candida albicans and cytotoxicities against human breast adenocarcinoma cell line MCF-7, human glioblastoma cell line SF-268 and human lung cancer cell line NCI-H460 were tested. Compounds 1 only displayed cytotoxicity against human breast adenocarcinoma cell line MCF-7 with the IC50 value of 27.0 μg/mL. However, compounds 1-5 do not show antifungal activities at the test concentration of 1 mg/mL, and 2-5 have no cytotoxicities at the test concentration of 50 μg/mL. PMID:27379435

  19. Early Holocene human remains from the Argentinean Pampas: additional evidence for distinctive cranial morphology of early South Americans.

    PubMed

    Pucciarelli, Héctor M; Perez, S Ivan; Politis, Gustavo G

    2010-10-01

    The cranial morphology of Early Holocene American human samples is characterized by a long and narrow cranial vault, whereas more recent samples exhibit a shorter and wider cranial vault. Two hypotheses have been proposed to account for the morphological differences between early and late-American samples: (a) the migratory hypothesis that suggests that the morphological variation between early and late American samples was the result of a variable number of migratory waves; and (b) the local diversification hypothesis, that is, the morphological differences between early and late American samples were mainly generated by local, random (genetic drift), and nonrandom factors (selection and phenotypic plasticity). We present the first craniometric study of three early skulls from the Argentinean Pampas, dated ∼8,000 cal. years BP (Arroyo Seco 2, Chocorí, and La Tigra), and one associated with mega-faunal remains (Fontezuelas skull). In addition, we studied several Late Holocene samples. We show that the skulls from the Argentinean Pampas are morphologically similar to other Early Holocene American skulls (i.e., Lagoa Santa from Brazil, Tequendama, Checua, and Aguazuque from Colombia, Lauricocha from Peru, and early Mexicans) that exhibit long and narrow cranial vaults. These samples differ from the Late Holocene American samples that exhibit a shorter and wider cranial vault. Our results underscore the important differences in cranial morphology between early and late-American samples. However, we emphasize the need for further studies to discuss alternative hypotheses regarding such differences. PMID:20623674

  20. Persistent Contamination of Octopuses and Mussels with Lipophilic Shellfish Toxins during Spring Dinophysis Blooms in a Subtropical Estuary.

    PubMed

    Mafra, Luiz L; Lopes, Daiana; Bonilauri, Vanessa C; Uchida, Hajime; Suzuki, Toshiyuki

    2015-06-01

    This study investigates the occurrence of diarrhetic shellfish toxins (DSTs) and their producing phytoplankton species in southern Brazil, as well as the potential for toxin accumulation in co-occurring mussels (Perna perna) and octopuses (Octopus vulgaris). During the spring in 2012 and 2013, cells of Dinophysis acuminata complex were always present, sometimes at relatively high abundances (max. 1143 cells L-1), likely the main source of okadaic acid (OA) in the plankton (max. 34 ng L-1). Dinophysis caudata occurred at lower cell densities in 2013 when the lipophilic toxins pectenotoxin-2 (PTX-2) and PTX-2 seco acid were detected in plankton and mussel samples. Here, we report for the first time the accumulation of DSTs in octopuses, probably linked to the consumption of contaminated bivalves. Perna perna mussels were consistently contaminated with different DSTs (max. 42 µg kg-1), and all octopuses analyzed (n = 5) accumulated OA in different organs/tissues: digestive glands (DGs) > arms > gills > kidneys > stomach + intestine. Additionally, similar concentrations of 7-O-palmytoyl OA and 7-O-palmytoly dinophysistoxin-1 (DTX-1) were frequently detected in the hepatopancreas of P. perna and DGs of O. vulgaris. Therefore, octopuses can be considered a potential vector of DSTs to both humans and top predators such as marine mammals. PMID:26096277

  1. Characterization of cytochalasins from the endophytic Xylaria sp. and their biological functions.

    PubMed

    Zhang, Qiang; Xiao, Jian; Sun, Qing-Qing; Qin, Jian-Chun; Pescitelli, Gennaro; Gao, Jin-Ming

    2014-11-12

    Bioassay-guided fractionation of the fermentation extract of Xylaria sp. XC-16, an endophyte from Toona sinensis led to the isolation of two new cytochalasans cytochalasin Z27, 1, and cytochalasin Z28, 2, along with three known compounds seco-cytochalasin E, 3, and cytochalasin Z18, 4, and cytochalasin E, 5. The structures of 1 and 2 were elucidated by spectroscopic and electronic circular dichroism methods. Compound 5 was shown to be potently cytotoxic against brine shrimp (LC50 = 2.79 μM), comparable to that of the positive agent toosendanin (LC50 = 4.03 μM), and also exhibited potential phytotoxic effects on Lactuca sativa and Raphanus sativus L. seedlings, which are higher than that of the positive control glyphosate. Additionally, the fungicidal effect of 2 against the phytopathogen Gibberella saubinetti was better than that of hymexazol. This is the first report of the three types of cytochalasins present in genus Xylaria. A structure-phytotoxicity activity relationship is also discussed. PMID:25350301

  2. 9,11-Secosteroids with cytotoxic activity from the South China Sea gorgonian coral Subergorgia suberosa.

    PubMed

    Zhang, Jun; Liu, Ling-Li; Zhong, Ba-Lian; Liao, Xiao-Jian; Xu, Shi-Hai

    2015-06-01

    Nine new 9,11-secosterols (1-9), containing the same 3β,6α,11-trihydroxy-9,11-seco-5α-cholest-7-en-9-one steroidal nucleus, whereas possessing an array of structurally diverse side chains, along with fourteen known 9,11-secosterol compounds (10-23), were isolated from the South China Sea gorgonian coral Subergorgia suberosa, of which 3/4, 5/6, 7/8, and the known compounds 11/12, 20/21 were five pairs of inseparable C-24 epimers. Their structures were established by the extensive analyses of 1D and 2D NMR spectra, high-resolution chemical ionization mass spectrometry (HRCIMS), and by the comparison with literature data. Cytotoxic effect of these metabolites against the growth of HeLa cell lines was evaluated. The result showed that the inhibitory effect of compounds 1-23 varied considerably depending on the nature of the side chain in spite of sharing the same steroidal nucleus. Compound 19, featuring both the absence of hydroxyl group and the presence of double bond in the stigmasterol side chain, exhibited the most potent cytotoxicity with IC50 being 15.1 μM. The preliminary structure activity relationship studies identified some important structural features considerably influencing the biological effect deserved, providing valuable information for chemists and pharmacologists to design and synthesize more effective antitumor agents bearing the 9,11-secosteroid framework.

  3. Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus.

    PubMed

    Chen, Zhenzhong; Tong, Ling; Feng, Yuanli; Wu, Jizhou; Zhao, Xiaoya; Ruan, Hanli; Pi, Huifang; Zhang, Peng

    2015-08-01

    Two nortriterpenes (rubuminatus A and B), which contain a distinctive contracted a five-membered A-ring ursane-type skeleton, and six triterpenes along with 17 known triterpenes were isolated from the roots of Rubus innominatus S. Moore. These structures were determined to be 19α-hydroxy-2-oxo-nor- A(3)-urs-12-en-28-oic acid, 1β,19α-dihydroxy-2-oxo-nor-A(3)-urs-12-en-28-oic acid, 1β,2α,3α,19α-tetrahy droxyurs-12-en-23-formyl-28-oic acid, 1β,2α,3α,19α,23- pentahydroxyurs-11-en-28-oic acid, 1-oxo-siaresinolic acid, 2α,3α-dihydroxyolean-11,13(18)-dien-19β,28-olide, 1β,2α,3α-trihydroxy-19-oxo- 18,19-seco-urs-11,13(18)-dien-28-oic acid, and 2-O-benzoyl alphitolic acid based on extensive spectroscopic analyses. In vitro anti-inflammatory abilities to modulate the production of TNF-α, IL-1β, and IL-6 in LPS-induced RAW 264.7 macrophages of the compounds were determined. Rubuminatus A and B, as well as 1-oxo-siaresinolic acid and 2α,3α-dihydroxyolean-11,13(18)-dien-19β,28-olide, exhibited significant inhibitory effects on these cytokines.

  4. Identification of Comamonas testosteroni as an androgen degrader in sewage

    PubMed Central

    Chen, Yi-Lung; Wang, Chia-Hsiang; Yang, Fu-Chun; Ismail, Wael; Wang, Po-Hsiang; Shih, Chao-Jen; Wu, Yu-Ching; Chiang, Yin-Ru

    2016-01-01

    Numerous studies have reported the masculinization of freshwater wildlife exposed to androgens in polluted rivers. Microbial degradation is a crucial mechanism for eliminating steroid hormones from contaminated ecosystems. The aerobic degradation of testosterone was observed in various bacterial isolates. However, the ecophysiological relevance of androgen-degrading microorganisms in the environment is unclear. Here, we investigated the biochemical mechanisms and corresponding microorganisms of androgen degradation in aerobic sewage. Sewage samples collected from the Dihua Sewage Treatment Plant (Taipei, Taiwan) were aerobically incubated with testosterone (1 mM). Androgen metabolite analysis revealed that bacteria adopt the 9, 10-seco pathway to degrade testosterone. A metagenomic analysis indicated the apparent enrichment of Comamonas spp. (mainly C. testosteroni) and Pseudomonas spp. in sewage incubated with testosterone. We used the degenerate primers derived from the meta-cleavage dioxygenase gene (tesB) of various proteobacteria to track this essential catabolic gene in the sewage. The amplified sequences showed the highest similarity (87–96%) to tesB of C. testosteroni. Using quantitative PCR, we detected a remarkable increase of the 16S rRNA and catabolic genes of C. testosteroni in the testosterone-treated sewage. Together, our data suggest that C. testosteroni, the model microorganism for aerobic testosterone degradation, plays a role in androgen biodegradation in aerobic sewage. PMID:27734937

  5. Stratigraphy and sedimentology of the Upper Cretaceous (Campanian) Anacacho Limestone, Texas, USA

    USGS Publications Warehouse

    Swezey, C.S.; Sullivan, E.C.

    2004-01-01

    The Upper Cretaceous Anacacho Limestone is exposed in outcrops between the cities of San Antonio and Del Rio, Texas. A detailed study of four outcrops (Blanco Creek section, Sabinal River section, Seco Creek section, Hondo Creek section) shows that the Anacacho Limestone rests on the Upson Clay (which contains fauna of early Campanian age) and is overlain by the Corsicana Marl (which contains fauna of early Maastrichtian age). An unconformity within the Anacacho Limestone is used herein to separate the limestone into a lower member and an upper member. The lower Anacacho member contains fauna of early Campanian age, whereas the upper Anacacho member contains fauna of middle Campanian age. The lower Anacacho member consists predominantly of wackestones to packstones, which are overlain by packstones to grainstones capped by the unconformity. This unconformity is interpreted as a marine flooding surface, delineating a transition from carbonate grainstones deposited in shallow water (<30 m depth) to a chalk deposited in deeper water. Above the unconformity, the upper Anacacho member is characterized by a chalk, overlain by wackestones and packstones. The uppermost section of the Anacacho Limestone consists of packstones and grainstones with abundant and diverse fossils. Most of the Anacacho Limestone developed in relatively shallow water (<50 m depth) leeward of a large carbonate build-up (possibly a rudistid reef) that now comprises the Anacacho Mountains. The environment, however, was open to marine water throughout deposition of the Anacacho Limestone. ?? 2004 Elsevier Ltd. All rights reserved.

  6. Biological and antigenic characterization of Netivot virus, an unusual new Orbivirus recovered from mosquitoes in Israel.

    PubMed

    Tesh, R B; Peleg, J; Samina, I; Margalit, J; Bodkin, D K; Shope, R E; Knudson, D

    1986-03-01

    The antigenic and biological characteristics of a new Orbivirus, designated Netivot virus, are described. This agent was originally recovered in cultures of the C6/36 clone of Aedes albopictus cells from a pool of Culex pipiens captured in Israel. Netivot virus is not pathogenic for newborn mice, nor did it initially produce detectable cytopathic effect (CPE) in Vero cells. It is closely related antigenically to Umatilla and Llano Seco viruses; these 3 agents appear to constitute a new serogroup within the genus Orbivirus. Netivot virus is also more distantly related to a number of other orbiviruses in the blue-tongue, epizootic hemorrhagic disease of deer, and Eubenangee serogroups. Netivot virus replicated to high titer and produced CPE in a variety of mosquito cell cultures, but it did not grow in 2 sand fly cell lines. Inoculation of Ae. aegypti and Ae. albopictus with Netivot virus resulted in almost 100% mortality in both species within 15 days after infection. The recovery of this and a number of other yet unidentified viral agents from field-collected mosquitoes in cultures of C6/36 cells, but not in the conventional vertebrate assay systems, suggests the existence in nature of many yet unrecognized mosquito-associated viruses. It also demonstrates the value of using new isolation methods in arbovirus studies. PMID:2869707

  7. Who pays to close a nuke

    SciTech Connect

    Pasqualetti, M.J.; Rothwell, G.

    1993-01-15

    Treating nuclear power plant decommissioning as an externality helps reduce the costs of the decisions we will be forced to make soon. According to the British magazine Atom, more than 60 nuclear power plants will be candidates for decommissioning worldwide by 2000. Another 350 commercial reactors worldwide will become eligible for decommissioning two decades after that. The United States has about one-quarter of the world's commercial reactors, many of which are nearing the end of their licensed life. While various organizations and government agencies debate the future direction of nuclear power in the United States, reactor retirements already are starting to accumulate. Vermont Yankee, Yankee Rowe, Indian Point 1, Dresden 1, LaCrosse, Peach Bottom 1, Ft. St. Vrain, Three Mile Island 2, Rancho Seco, and Humboldt Bay 3 all have been announced for decommissioning. Shippingport Atomic Station, near Pittsburgh, has been dismantled and removed. Many questions are emerging as the specter of abandoned hulks and mountains of radioactive debris begins to loom on the horizon. A useful way to address some of the problems of nuclear decommissioning is through the work of University of Chicago Professor Ronald Coase. Coase received the Nobel Prize in economics in October 1991 primarily for his work on externalities; that is, the by-products of production or consumption activities that affect others besides the producer or consumer.

  8. Applications of Anabolic Vitamin D Analogs as Countermeasures to Bone Loss

    NASA Technical Reports Server (NTRS)

    Karin, Norman J.

    1998-01-01

    The experiments in Round 2 were designed to extend the results of our efforts in Round 1 which led us to hypothesize that the seco-steroid, 1,25-dihydroxyvitamin D3[1,25(OH)2D3], acts in synergy with parathyroid hormone (PTH) to regulate bone calcium homeostasis. Our work centered on one particular target of 1,25(OH)2D3 action, the voltage-sensitive calcium channels (VSCC's), which are activated acutely by this steroid within milliseconds of exposure . A second area of research focused on the effects of mechanical strain on VSCC expression in bone. These experiments were performed in collaboration with Dr. Steven Goldstein (Univ. Michigan), who generously provided RNA extracted from dog bones that had been exposed to mechanical strain in vivo. Our results suggest that mechanical loading elevated VSCC expression in the long bones from 3 of the 6 animals tested. A second line of experimentation, carried out in collaboration with Dr. Randall Duncan, a NASA-funded investigator in Indianapolis, centered on RT-PCR analysis of effects of mechanical strain on Ca2(+) channel expression in cultured bone cells. Compared to unstrained controls, the expression of vitamin-D-sensidve Ca2(+) channels is elevated 3- to 5-fold over a 24 hr period.

  9. An entomological and seroepidemiological study of the vectorial-transmission risk of Chagas disease in the coast of northern Chile.

    PubMed

    González, C R; Reyes, C; Canals, A; Parra, A; Muñoz, X; Rodríguez, K

    2015-12-01

    Four species of triatomines are known from Chile: Triatoma infestans Klug, Mepraia spinolai Porter, M. gajardoi Frías, Henry & González, and M. parapatrica Frías (Hemiptera: Reduviidae), the last three are endemic. The geographical distribution of M. gajardoi includes the coastal areas in the north of Chile between 18° and 21°S, an area with both a resident workforce and summer-season visitors. A study was developed to assess the risk of vectorial transmission of Chagas disease by M. gajardoi in hut settlements on the coast of the Tarapacá Region, in particular in Caleta San Marcos and Caleta Río Seco. The study comprised fingerstick sampling of 95 persons, venous samples from 29 domestic dogs and capture of 52 triatomines, from both fishing coves. The samples were analysed by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) techniques. The results show that, of the total number of persons studied, 100% were negative for Trypanosoma cruzi Chagas (Trypanosomatida: Trypanosomatidae) antibodies, 10.34% of canids were positive for the antibody and 5.8% of M. gajardoi were infected to the PCR technique. The presence of this species in areas close to human settlements constitutes a risk to human populations established on the coast of northern Chile.

  10. INTEGRATED VERTICAL AND OVERHEAD DECONTAMINATION (IVOD) SYSTEM

    SciTech Connect

    M.A. Ebadian, Ph.D.

    2001-01-01

    The deactivation and decommissioning of 1200 buildings within the U.S. Department of Energy-Office of Environmental Management complex will require the disposition of a large quantity of contaminated concrete and metal surfaces. It has been estimated that 23 million cubic meters of concrete and over 600,000 tons of metal will need disposition. The disposition of such large quantities of material presents difficulties in the area of decontamination and characterization. The final disposition of this large amount of material will take time and money as well as risk to the D&D work force. A single automated system that would decontaminate and characterize surfaces in one step would not only reduce the schedule and decrease cost during D&D operations but would also protect the D&D workers from unnecessary exposures to contaminated surfaces. This report summarizes the activities performed during FY00 and describes the planned activities for FY01. Accomplishments for FY00 include the following: Development and field-testing of characterization system; Completion of Title III design of deployment platform and decontamination unit; In-house testing of deployment platform and decontamination unit; Completion of system integration design; Identification of deployment site; and Completion of test plan document for deployment of IVOD at Rancho Seco nuclear power facility.

  11. Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (-)-Lyngbyaloside B.

    PubMed

    Fuwa, Haruhiko; Yamagata, Naoya; Okuaki, Yuta; Ogata, Yuya; Saito, Asami; Sasaki, Makoto

    2016-05-10

    We have described in detail the total synthesis of both the proposed and correct structures of (-)-lyngbyaloside B, which facilitated the elucidation of the complete stereostructure of this natural product. Our study began with the total synthesis of 13-demethyllyngbyaloside B, in which an esterification/ring-closing metathesis (RCM) strategy was successfully used for the efficient construction of the macrocycle. We also established reliable methods for the introduction of the conjugated diene side chain and the l-rhamnose residue onto the macrocyclic framework. However, the esterification/RCM strategy proved ineffective for the parent natural product because of the difficulties in acylating the sterically encumbered C-13 tertiary alcohol; macrolactionization of a seco-acid was also extensively investigated under various conditions without success. We finally completed the total synthesis of the proposed structure of (-)-lyngbyaloside B by means of a macrolactonization that involves an acyl ketene as the reactive species. However, the NMR spectroscopic data of our synthetic material did not match those of the authentic material, which indicated that the proposed structure must be re-examined. Inspection of the NMR spectroscopic data of the natural product and molecular mechanics calculations led us to postulate that the configuration of the C-10, C-11, and C-13 stereogenic centers had been incorrectly assigned in the proposed structure. Finally, our revised structure of (-)-lyngbyaloside B was unambiguously verified through total synthesis. PMID:27112323

  12. Mechanical cutting of irradiated reactor internal components

    SciTech Connect

    Anderson, Michael G.

    2008-01-15

    Mechanical cutting methods to volume reduce and package reactor internal components are now a viable solution for stakeholders challenged with the retirement of first generation nuclear facilities. The recent completion of the removal of the Reactor Vessel Internals (RVI) from within the Sacramento Municipal Utility District's (SMUD) Rancho Seco Nuclear Power Plant demonstrates that unlike previous methods, inclusive of plasma arc and abrasive water-jet cutting, mechanical cutting minimizes exposure to workers, costly water cleanup, and excessive secondary waste generation. Reactor internal components were segmented, packaged, and removed from the reactor building for shipment or storage, allowing the reactor cavity to be drained and follow-on reactor segmentation activities to proceed in the dry state. Area exposure rates at the work positions during the segmentation process were generally 1 mR per hr. Radiological exposure documented for the underwater segmentation processes totaled 13 person rem. The reactor internals weighing 343,000 pounds were segmented into over 200 pieces for maximum shipping package efficiency and produced 5,600 lb of stainless steel chips and shavings which were packaged in void spaces of existing disposal containers, therefore creating no additional disposal volume. Because no secondary waste was driven into suspension in the reactor cavity water, the water was free released after one pass through a charcoal bed and ion exchange filter system. Mechanical cutting techniques are capable of underwater segmentation of highly radioactive components on a large scale. This method minimized radiological exposure and costly water cleanup while creating no secondary waste.

  13. Relationship between High-Performance Liquid Chromatography Fingerprints and Uric Acid-Lowering Activities of Cichorium intybus L.

    PubMed

    Zhu, Chun-Sheng; Zhang, Bing; Lin, Zhi-Jian; Wang, Xue-Jie; Zhou, Yue; Sun, Xiao-Xia; Xiao, Ming-Liang

    2015-01-01

    This study aimed to explore the spectrum-effect relationships between high-performance liquid chromatography fingerprints and the uric acid-lowering activities of chicory. Chemical fingerprints of chicory samples from ten different sources were determined by high-performance liquid chromatography, and then investigated by similarity analysis and hierarchical clustering analysis. Pharmacodynamics experiments were conducted in animals to obtain the uric acid-lowering activity information of each chicory sample. The spectrum-effect relationships between chemical fingerprints and the uric acid-lowering activities of chicory were established by canonical correlation analysis. The structures of potential effective peaks were identified by liquid chromatography with tandem mass spectrometry. The results showed that a close correlation existed between the spectrum and effect of chicory. Aesculin, chlorogenic acid, chicoric acid, isochlorogenic acid A/B/C and 13,14-seco-stigma5(6),14(15)-diene-3α-ol might be the main effective constituents. This work provides a general model of the combination of high-performance liquid chromatography and uric acid-lowering activities to study the spectrum-effect relationships of chicory, which can be used to discover the principle components responsible for the bioactivity. PMID:26007193

  14. Ground temperature regime and periglacial dynamics in three different sites from the summit area in Sierra Nevada (southern Spain) from 2006 to 2012

    NASA Astrophysics Data System (ADS)

    Salvador-Franch, Ferran; Oliva, Marc; Salva-Catarineu, Montserrat; Gómez-Ortiz, Antonio

    2013-04-01

    Ground temperatures and its control on snow cover are crucial factors conditioning the activity of current periglacial processes in the highest lands of Sierra Nevada (Betique Range, Iberian Peninsula). We present summary results of the monitoring period from September 2006 to August 2012 in three sites with contrasting topography, aspect and snow cover. Temperatures loggers have recorded data at 2 hours time lapse at: a) Veleta glacial cirque, an environment with marginal permafrost and a small active rock glacier in it (3107 m asl), b) the flat summit plateau of Collado de los Machos (3297 m) characterized by the existence of inactive sorted circles with scarce snow cover, and c) the southern cirque of Rio Seco, an area with moderate snow cover and widespread solifluction lobes (3105 m). We discuss the periglacial activity in the three study sites in relation with ground temperatures. Results show evidence of the decisive control played by snow cover (duration and thickness) in the thermal regime of the ground (rhythm, depth and intensity of freezing). Only the site in the Veleta cirque has revealed the existence of permafrost, which is inexistent at the summit plateaus and southern cirques. The freezing and thawing of the ground depends substantially on the geographical characteristics of the sites, although a common pattern is detected: the thawing occurs more rapidly than the freezing and the number of freeze-thaw cycles in air temperatures is substantially higher than in ground temperatures.

  15. PRODUCTION OF FOAMS, FIBERS AND PITCHES USING A COAL EXTRACTION PROCESS

    SciTech Connect

    Chong Chen; Elliot B. Kennel; Liviu Magean; Pete G. Stansberry; Alfred H. Stiller; John W. Zondlo

    2004-06-20

    This Department of Energy National Energy Technology Laboratory sponsored project developed processes for converting coal feedstocks to carbon products, including coal-derived pitch, coke foams and fibers based on solvent extraction processes. A key technology is the use of hydrogenation accomplished at elevated temperatures and pressures to obtain a synthetic coal pitch. Hydrogenation, or partial direct liquefaction of coal, is used to modify the properties of raw coal such that a molten synthetic pitch can be obtained. The amount of hydrogen required to produce a synthetic pitch is about an order of magnitude less than the amount required to produce synthetic crude oil. Hence the conditions for synthetic pitch production consume very little hydrogen and can be accomplished at substantially lower pressure. In the molten state, hot filtration or centrifugation can be used to separate dissolved coal chemicals from mineral matter and insolubles (inertinite), resulting in the production of a purified hydrocarbon pitch. Alternatively, if hydrogenation is not used, aromatic hydrocarbon liquids appropriate for use as precursors to carbon products can obtained by dissolving coal in a solvent. As in the case for partial direct liquefaction pitches, undissolved coal is removed via hot filtration or centrifugation. Excess solvent is boiled off and recovered. The resultant solid material, referred to as Solvent Extracted Carbon Ore or SECO, has been used successfully to produce artificial graphite and carbon foam.

  16. Preliminary Evaluation of Removing Used Nuclear Fuel from Shutdown Sites

    SciTech Connect

    Maheras, Steven J.; Best, Ralph E.; Ross, Steven B.; Buxton, Kenneth A.; England, Jeffery L.; McConnell, Paul E.

    2013-09-30

    This report fulfills the M2 milestone M2FT-13PN0912022, “Stranded Sites De-Inventorying Report.” In January 2013, the U.S. Department of Energy (DOE) issued the Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste (DOE 2013). Among the elements contained in this strategy is an initial focus on accepting used nuclear fuel from shutdown reactor sites. This focus is consistent with the recommendations of the Blue Ribbon Commission on America’s Nuclear Future, which identified removal of stranded used nuclear fuel at shutdown sites as a priority so that these sites may be completely decommissioned and put to other beneficial uses (BRC 2012). Shutdown sites are defined as those commercial nuclear power reactor sites where the nuclear power reactors have been shut down and the site has been decommissioned or is undergoing decommissioning. In this report, a preliminary evaluation of removing used nuclear fuel from 12 shutdown sites was conducted. The shutdown sites were Maine Yankee, Yankee Rowe, Connecticut Yankee, Humboldt Bay, Big Rock Point, Rancho Seco, Trojan, La Crosse, Zion, Crystal River, Kewaunee, and San Onofre. These sites have no other operating nuclear power reactors at their sites and have also notified the U.S. Nuclear Regulatory Commission that their reactors have permanently ceased power operations and that nuclear fuel has been permanently removed from their reactor vessels. Shutdown reactors at sites having other operating reactors are not included in this evaluation.

  17. An entomological and seroepidemiological study of the vectorial-transmission risk of Chagas disease in the coast of northern Chile.

    PubMed

    González, C R; Reyes, C; Canals, A; Parra, A; Muñoz, X; Rodríguez, K

    2015-12-01

    Four species of triatomines are known from Chile: Triatoma infestans Klug, Mepraia spinolai Porter, M. gajardoi Frías, Henry & González, and M. parapatrica Frías (Hemiptera: Reduviidae), the last three are endemic. The geographical distribution of M. gajardoi includes the coastal areas in the north of Chile between 18° and 21°S, an area with both a resident workforce and summer-season visitors. A study was developed to assess the risk of vectorial transmission of Chagas disease by M. gajardoi in hut settlements on the coast of the Tarapacá Region, in particular in Caleta San Marcos and Caleta Río Seco. The study comprised fingerstick sampling of 95 persons, venous samples from 29 domestic dogs and capture of 52 triatomines, from both fishing coves. The samples were analysed by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) techniques. The results show that, of the total number of persons studied, 100% were negative for Trypanosoma cruzi Chagas (Trypanosomatida: Trypanosomatidae) antibodies, 10.34% of canids were positive for the antibody and 5.8% of M. gajardoi were infected to the PCR technique. The presence of this species in areas close to human settlements constitutes a risk to human populations established on the coast of northern Chile. PMID:26208149

  18. Molecular structure and vibrational bands and 13C chemical shift assignments of both enmein-type diterpenoids by DFT study.

    PubMed

    Wang, Tao; Wu, Yi fang; Wang, Xue liang

    2014-01-01

    We report here theoretical and experimental studies on the molecular structure and vibrational and NMR spectra of both natural enmein type diterpenoids molecule (6, 7-seco-ent-kaurenes enmein type), isolated from the leaves of Isodon japonica (Burm.f.) Hara var. galaucocalyx (maxin) Hara. The optimized geometry, total energy, NMR chemical shifts and vibrational wavenumbers of epinodosinol and epinodosin have been determined using B3LYP method with 6-311G (d,p) basis set. A complete vibrational assignment is provided for the observed IR spectra of studied compounds. The calculated wavenumbers and 13C c.s. are in an excellent agreement with the experimental values. Quantum chemical calculations at the B3LYP/6-311G (d,p) level of theory have been carried out on studied compounds to obtain a set of molecular electronic properties (MEP,HOMO, LUMO and gap energies ΔEg). Electrostatic potential surfaces have been mapped over the electron density isosurfaces to obtain information about the size, shape, charge density distribution and chemical reactivity of the molecules. PMID:24013676

  19. One new and six known triterpene xylosides from Cimicifuga racemosa: FT-IR, Raman and NMR studies and DFT calculations

    NASA Astrophysics Data System (ADS)

    Jamróz, Marta K.; Jamróz, Michał H.; Cz. Dobrowolski, Jan; Gliński, Jan A.; Gleńsk, Michał

    One new and six known triterpene xylosides were isolated from Cimicifuga racemosa (black cohosh, Actaea racemosa). The structure of a new compound, designated as isocimipodocarpaside (1), was established to be (24S)-3β-hydroxy-24,25-oxiirane-16,23-dione-9,10-seco-9,19-cyclolanost-1(10),7(8),9(11)-trien 3-O-β-D-xylopyranoside, by means of 1H and 13C NMR, IR and Raman spectroscopies and Mass Spectrometry. The six known compounds are: 23-epi-26-deoxycimicifugoside (2), 23-epi-26-deoxyactein (3), 25-anhydrocimigenol xyloside (4), 23-O-acetylshengmanol xyloside (5), 25-O-acetylcimigenol xyloside (6) and 3'-O-acetylcimicifugoside H-1 (7). On the basis of NMR data supported by DFT calculations of NMR shielding constants of (2), its structure, previously described as 26-deoxycimicifugoside was corrected and determined as 23-epi-26-deoxycimicifugoside. The 13C CPMAS NMR spectra of the studied compounds (1)-(7) provided data on their solid-state interactions. The IR and Raman spectra in the Cdbnd O, Cdbnd C, and Csbnd H stretching vibration regions clearly discriminate different triterpenes found in C. racemosa.

  20. Oleanane-type triterpene saponins from Hydrocotyle nepalensis.

    PubMed

    Ma, Rui-Jing; Liu, Zhen-Hua; Zi, Cheng-Ting; Gao, Wei; Dong, Fa-Wu; Yang, Liu; Li, Jin-Yu; Zhou, Jun; Hu, Jiang-Miao

    2016-04-01

    Five new oleanane-type triterpene saponins including steganogenin 3-O-β-D-glucopyranoside (1), steganogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (2), steganogenin 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (3), chichipegenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (4) and chichipegenin 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (5), along with four known oleanane-type triterpenes and triterpene saponins (6-9) were isolated from EtOH extract of the whole plant of Hydrocotyle nepalensis. To the best of our knowledge, oleanane-type triterpenes possessing skeleton with 17, 22-seco-backbone (1-3) are not common in natural products. Compound 8 was isolated as a new natural product. The structures of new compounds were elucidated by extensive spectroscopic methods and chemical evidence. Moreover, the cytotoxic activity of all the isolates against five selected human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) was evaluated and the results indicated that compounds 6 and 7 show stronger cytotoxic activity. PMID:26851174

  1. Brief account of the effect of overcooling accidents on the integrity of PWR pressure vessels

    SciTech Connect

    Cheverton, R.D.

    1982-01-01

    The occurrence in recent years of several (PWR) accident initiating events that could lead to severe thermal shock to the reactor pressure vessel, and the growing awareness that copper and nickel in the vessel material significantly enhance radiation damage in the vessel, have resulted in a reevaluation of pressure-vessel integrity during postulated overcooling accidents. Analyses indicate that the accidents of concern are those involving both thermal shock and pressure loadings, and that an accident similar to that at Rancho Seco in 1978 could, under some circumstances and at a time late in the normal life of the vessel, result in propagation of preexistent flaws in the vessel wall to the extent that they might completely penetrate the wall. More severe accidents have been postulated that would result in even shorter permissible lifetimes. However, the state-of-the-art fracture-mechanics analysis may contain excessive conservatism, and this possibility is being investigated. Furthermore, there are several remedial measures, such as fuel shuffling, to reduce the damage rate, and vessel annealing, to restore favorable material properties, that may be practical and used if necessary. 5 figures.

  2. Using genotoxic and haematological biomarkers as an evidence of environmental contamination in the Ocoa River native fish, Villavicencio-Meta, Colombia.

    PubMed

    Corredor-Santamaría, Wilson; Serrano Gómez, Marlon; Velasco-Santamaría, Yohana María

    2016-01-01

    The studies evaluating the impact of environmental pollution on aquatic organisms have had a growing concern in recent decades. The Ocoa River runs through Villavicencio city, receiving the wastewater produced in the city. To date studies reporting the effect and the consequences of Ocoa River pollution on aquatic organisms inhabiting this water body are unknown. Haematological and genotoxicity biomarkers were evaluated in peripheral blood of two native fish species Astyanax gr. bimaculatus and Aequidens metae during rainy and dry season at three different sites of Ocoa River called Nacimiento (site 1, before entering the city), Centauros (site 2, inside the city), Caño Seco (site 3, after the city). Also, fish from a reference site with little likelihood of contamination were sampled. Alterations such as decrease in erythrocyte count, lymphocytes, haemoglobin concentration and haematocrit percentage, and increased thrombocytes and neutrophils counts, together with nuclear abnormalities in erythrocytes such as increased frequency of micronuclei, lobed, blebbed and notched nuclei and binucleate cells were observed in fish from the site 3, followed by the site 2 in rainy season. These results shown that during rainy season, sites 2 and 3 receive domestic and industrial wastewater leading to genotoxic and haematological changes in the monitored organisms. PMID:27066365

  3. Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway.

    PubMed

    Ginis, Olivia; Courdavault, Vincent; Melin, Céline; Lanoue, Arnaud; Giglioli-Guivarc'h, Nathalie; St-Pierre, Benoit; Courtois, Martine; Oudin, Audrey

    2012-05-01

    The Madagascar periwinkle produces monoterpenoid indole alkaloids (MIA) of high interest due to their therapeutical values. The terpenoid moiety of MIA is derived from the methyl erythritol phosphate (MEP) and seco-iridoid pathways. These pathways are regarded as the limiting branch for MIA biosynthesis in C. roseus cell and tissue cultures. In previous studies, we demonstrated a coordinated regulation at the transcriptional and spatial levels of genes from both pathways. We report here on the isolation of the 5'-flanking region (1,049 bp) of the hydroxymethylbutenyl 4-diphosphate synthase (HDS) gene from the MEP pathway. To investigate promoter transcriptional activities, the HDS promoter was fused to GUS reporter gene. Agrobacterium-mediated transformation of young tobacco leaves revealed that the cloned HDS promoter displays a tissue-specific GUS staining restricted to the vascular region of the leaves and limited to a part of the vein that encompasses the phloem in agreement with the previous localization of HDS transcripts in C. roseus aerial organs. Further functional characterizations in stably or transiently transformed C. roseus cells allowed us to identify the region that can be consider as the minimal promoter and to demonstrate the induction of HDS promoter by several hormonal signals (auxin, cytokinin, methyljasmonate and ethylene) leading to MIA production. These results, and the bioinformatic analysis of the HDS 5'-region, suggest that the HDS promoter harbours a number of cis-elements binding specific transcription factors that would regulate the flux of terpenoid precursors involved in MIA biosynthesis.

  4. Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus.

    PubMed

    Chen, Zhenzhong; Tong, Ling; Feng, Yuanli; Wu, Jizhou; Zhao, Xiaoya; Ruan, Hanli; Pi, Huifang; Zhang, Peng

    2015-08-01

    Two nortriterpenes (rubuminatus A and B), which contain a distinctive contracted a five-membered A-ring ursane-type skeleton, and six triterpenes along with 17 known triterpenes were isolated from the roots of Rubus innominatus S. Moore. These structures were determined to be 19α-hydroxy-2-oxo-nor- A(3)-urs-12-en-28-oic acid, 1β,19α-dihydroxy-2-oxo-nor-A(3)-urs-12-en-28-oic acid, 1β,2α,3α,19α-tetrahy droxyurs-12-en-23-formyl-28-oic acid, 1β,2α,3α,19α,23- pentahydroxyurs-11-en-28-oic acid, 1-oxo-siaresinolic acid, 2α,3α-dihydroxyolean-11,13(18)-dien-19β,28-olide, 1β,2α,3α-trihydroxy-19-oxo- 18,19-seco-urs-11,13(18)-dien-28-oic acid, and 2-O-benzoyl alphitolic acid based on extensive spectroscopic analyses. In vitro anti-inflammatory abilities to modulate the production of TNF-α, IL-1β, and IL-6 in LPS-induced RAW 264.7 macrophages of the compounds were determined. Rubuminatus A and B, as well as 1-oxo-siaresinolic acid and 2α,3α-dihydroxyolean-11,13(18)-dien-19β,28-olide, exhibited significant inhibitory effects on these cytokines. PMID:25944373

  5. The Arrival of Homo sapiens into the Southern Cone at 14,000 Years Ago

    PubMed Central

    Politis, Gustavo G.; Gutiérrez, María A.; Blasi, Adriana

    2016-01-01

    The Arroyo Seco 2 site contains a rich archaeological record, exceptional for South America, to explain the expansion of Homo sapiens into the Americas and their interaction with extinct Pleistocene mammals. The following paper provides a detailed overview of material remains found in the earliest cultural episodes at this multi-component site, dated between ca. 12,170 14C yrs B.P. (ca. 14,064 cal yrs B.P.) and 11,180 14C yrs B.P. (ca. 13,068 cal yrs B.P.). Evidence of early occupations includes the presence of lithic tools, a concentration of Pleistocene species remains, human-induced fractured animal bones, and a selection of skeletal parts of extinct fauna. The occurrence of hunter-gatherers in the Southern Cone at ca. 14,000 cal yrs B.P. is added to the growing list of American sites that indicate a human occupation earlier than the Clovis dispersal episode, but posterior to the onset of the deglaciation of the Last Glacial Maximum (LGM) in the North America. PMID:27683248

  6. Isostatic gravity map of the Point Sur 30 x 60 quadrangle and adjacent areas, California

    USGS Publications Warehouse

    Watt, J.T.; Morin, R.L.; Langenheim, V.E.

    2011-01-01

    This isostatic residual gravity map is part of a regional effort to investigate the tectonics and water resources of the central Coast Range. This map serves as a basis for modeling the shape of basins and for determining the location and geometry of faults in the area. Local spatial variations in the Earth's gravity field (after removing variations caused by instrument drift, earth-tides, latitude, elevation, terrain, and deep crustal structure), as expressed by the isostatic anomaly, reflect the distribution of densities in the mid- to upper crust, which in turn can be related to rock type. Steep gradients in the isostatic gravity field often indicate lithologic or structural boundaries. Gravity highs reflect the Mesozoic granitic and Franciscan Complex basement rocks that comprise both the northwest-trending Santa Lucia and Gabilan Ranges, whereas gravity lows in Salinas Valley and the offshore basins reflect the thick accumulations of low-density alluvial and marine sediment. Gravity lows also occur where there are thick deposits of low-density Monterey Formation in the hills southeast of Arroyo Seco (>2 km, Marion, 1986). Within the map area, isostatic residual gravity values range from approximately -60 mGal offshore in the northern part of the Sur basin to approximately 22 mGal in the Santa Lucia Range.

  7. Does biopolymers composition in seeds contribute to the flax resistance against the Fusarium infection?

    PubMed

    Zeitoun, Ahmed M; Preisner, Marta; Kulma, Anna; Dymińska, Lucyna; Hanuza, Jerzy; Starzycki, Michal; Szopa, Jan

    2014-01-01

    Over the last decades, the cultivation of fibrous flax declined heavily. There are number of reasons for that fact; one of them is flax susceptibility to the pathogen infection. Damages caused mainly by fungi from genus Fusarium lead to the significant losses when cultivating flax, which in turn discourage farmers to grow flax. Therefore, to launch the new products from flax with attractive properties there is a need to obtain new flax varieties with increased resistance to pathogens. In order to obtain the better quality of flax fiber, we previously generated flax with reduced pectin or lignin level (cell wall polymers). The modifications altered also plants' resistance to the Fusarium infection. Undoubtedly, the plant defense system is complex, however, in this article we aimed to investigate the composition of modified flax seeds and to correlate it with the observed changes in the flax resistance to the pathogen attack. In particular, we evaluated the content and composition of carbohydrates (cell wall polymers: pectin, cellulose, hemicelluloses and mucilage), and phenylpropanoid compounds (lignin, lignans, phenolics). From the obtained results we concluded that the observed changes in the vulnerability to pathogens putatively correlate with the antioxidant potential of phenylpropanoids accumulated in seeds, seco-isolariciresinol and coumaric acid diglycosides in particular, and with pectin level as a carbon source for pathogens. Surprisingly, relatively less important for the resistance was the physical barrier, including lignin and cellulose amount and cellulose structure. Certainly, the hypothesis should be verified on a larger number of genotypes.

  8. Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam.

    PubMed

    Herrera-Arellano, Armando; Jiménez-Ferrer, Enrique; Zamilpa, Alejandro; Morales-Valdéz, Marisol; García-Valencia, Claudia E; Tortoriello, Jaime

    2007-07-01

    Galphimia glauca Cav. is a plant used in Mexican traditional medicine as a "nerve tranquilizer". Previous studies have demonstrated that the methanolic extract from this plant species possess an anxiolytic effect. Galphimine B (GB, a nor-seco-triterpene), is the active principle, with an innovative action mechanism. Against this background, a standardized herbal medicinal product was developed from the aqueous extract of G. glauca (GgHP). The present work compared the therapeutic effectiveness, safety, and tolerability of the new GgHP with lorazepam on patients with generalized anxiety disorder (GAD). By means of a controlled, randomized, double-blind clinical trial, outpatients of either sex who matched the DSM-IV diagnostic criteria with a score of > or = 19 points on the Hamilton Anxiety Scale (HAM-A) were included. The experimental group was treated orally with GgHP in capsules twice a day for 4 weeks. The control group received lorazepam (1 mg) under the same conditions and presentation. A total of 152 patients were included in the trial (72 in the experimental group). From the first week of treatment, GgHP showed important anxiolytic effectiveness, very similar to that produced with lorazepam. Both treatments showed therapeutic safety (no alterations on biochemical analysis of hepatic and renal function). Nevertheless, concerning side effects, GgHP evidenced a considerably higher tolerability than lorazepam.

  9. Preservation of large titanosaur sauropods in overbank fluvial facies: A case study in the Cretaceous of Argentina

    NASA Astrophysics Data System (ADS)

    González Riga, Bernardo J.; Astini, Ricardo A.

    2007-04-01

    Patagonia exhibits a particularly abundant record of Cretaceous dinosaurs with worldwide relevance. Although paleontological studies are relatively numerous, few include taphonomic information about these faunas. This contribution provides the first detailed sedimentological and taphonomical analyses of a dinosaur bone quarry from northern Neuquén Basin. At Arroyo Seco (Mendoza Province, Argentina), a large parautochthonous/autochthonous accumulation of articulated and disarticulated bones that represent several sauropod individuals has been discovered. The fossil remains, assigned to Mendozasaurus neguyelap González Riga, correspond to a large (18-27-m long) sauropod titanosaur collected in the strata of the Río Neuquén Subgroup (late Turoronian-late Coniacian). A taphonomic viewpoint recognizes a two-fold division into biostratinomic and fossil-diagenetic processes. Biostratinomic processes include (1) subaerial biodegradation of sauropod carcasses on well-drained floodplains, (2) partial or total skeletal disarticulation, (3) reorientation of bones by sporadic overbank flows, and (4) subaerial weathering. Fossil-diagenetic processes include (1) plastic deformation of bones, (2) initial permineralization with hematite, (3) fracturing and brittle deformation due to lithostatic pressure; (4) secondary permineralization with calcite in vascular canals and fractures, and (5) postfossilization bone weathering. This type of bone concentration, also present in Rincón de los Sauces (northern Patagonia), suggests that overbank facies tended to accumulate large titanosaur bones. This taphonomic mode, referred to as "overbank bone assemblages", outlines the potential of crevasse splay facies as important sources of paleontological data in Cretaceous meandering fluvial systems.

  10. Microbiological transformation of two 15α-hydroxy-ent-kaur-9(11),16-diene derivatives by the fungus Fusarium fujikuroi.

    PubMed

    Fraga, Braulio M; González-Vallejo, Victoria; Guillermo, Ricardo; Amaro-Luis, Juan M

    2013-05-01

    The incubation of 15α-hydroxy-ent-kaur-9(11),16-dien-19-oic acid (15α-hydroxy-grandiflorenic acid) with the fungus Fusarium fujikuroi gave as main metabolite its 3β,6β-dihydroxy derivative, which by an oxidative decarboxylation afforded a 19-nor compound with a 4,18-double bond. Other substances obtained were a 3α-hydroxy-19,6α-lactone, 3β-hydroxy-6β,7β-epoxy-ent-kaur-9(11),16-dien-19-oic acid and 3β-hydroxy-6-oxo-ent-kaur-9(11),16-dien-19-oic acid. Moreover, the biotransformation of 15α,18-dihydroxy-ent-kaur-9(11),16-diene led to the isolation of the corresponding 3β-, 6β-, 7α- and 12β-hydroxy derivatives. Two metabolites formed by 16β,17-epoxidation of the last compound and of the substrate were also obtained. These results indicated that the presence of the 9,11-double bond in the substrate impedes its 7β-hydroxylation, which is necessary for the formation of gibberellins and seco-ring B ent-kaurenoids. However, this 9,11-unsaturation does not hinder a 6,7-dehydrogenation and further 6β,7β-epoxidation, characteristic steps of the kaurenolide biosynthetic pathway.

  11. Genome Mining in Streptomyces avermitilis. A Biochemical Baeyer-Villiger Reaction and Discovery of a New Branch of the Pentalenolactone Family Tree†

    PubMed Central

    Jiang, Jiaoyang; Tetzlaff, Charles N.; Takamatsu, Satoshi; Iwatsuki, Masato; Komatsu, Mamoru; Ikeda, Haruo; Cane, David E.

    2009-01-01

    Incubation of 1-deoxy-11-oxopentalenic acid (12) with recombinant PtlE protein from Streptomyces avermitilis in the presence of NADPH and catalytic FAD gave the Baeyer-Villiger oxidation product, the previously unknown compound neopentalenolactone D (13), representing a new branch of the pentalenolactone biosynthetic pathway. The structure and stereochemistry of the derived neopentalenolactone D methyl ester (13-Me) were fully assigned by a combination of GC-MS and NMR analysis and confirmed by X-ray crystallography. Neopentalenolactone D (13) was also isolated from engineered cultures of S. avermitilis from which the ptlD gene within the 13.4-kb (neo)-ptl biosynthetic gene cluster had been deleted. The ΔptlEΔptlD double deletion mutant accumulated 12, the substrate for the ptlE gene product, while the corresponding single ΔptlE mutant produced 12 as well as the related oxidation products 14 and 15. Engineered strains of S. avermitilis, SUKA5 and pKU462::ermRp-ptl cluster, harboring the complete (neo)ptl cluster produced the oxidized lactone 18 and the closely related seco acid hydrolysis products 16 and 17. PMID:19485417

  12. Independent assessment of TRAC-PD2 and RELAP5/MOD1 codes at BNL in FY 1981. [PWR

    SciTech Connect

    Saha, P; Jo, J H; Neymotin, L; Rohatgi, U S; Slovik, G

    1982-12-01

    This report documents the independent assessment calculations performed with the TRAC-PD2 and RELAP/MOD1 codes at Brookhaven National Laboratory (BNL) during Fiscal Year 1981. A large variety of separate-effects experiments dealing with (1) steady-state and transient critical flow, (2) level swell, (3) flooding and entrainment, (4) steady-state flow boiling, (5) integral economizer once-through steam generator (IEOTSG) performance, (6) bottom reflood, and (7) two-dimensional phase separation of two-phase mixtures were simulated with TRAC-PD2. In addition, the early part of an overcooling transient which occurred at the Rancho Seco nuclear power plant on March 20, 1978 was also computed with an updated version of TRAC-PD2. Three separate-effects tests dealing with (1) transient critical flow, (2) steady-state flow boiling, and (3) IEOTSG performance were also simulated with RELAP5/MOD1 code. Comparisons between the code predictions and the test data are presented.

  13. Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.

    PubMed

    Naman, C Benjamin; Gromovsky, Anthony D; Vela, Cory M; Fletcher, Joshua N; Gupta, Gaurav; Varikuti, Sanjay; Zhu, Xiaohua; Zywot, Emilia M; Chai, Heebyung; Werbovetz, Karl A; Satoskar, Abhay R; Kinghorn, A Douglas

    2016-03-25

    Two new compounds, namely, a para-benzoquinone ring-containing abietane (1) and a para-benzoquinone ring-containing 7,8-seco-abietane (2), and 14 other known highly oxidized abietane diterpenoids (3-16) were isolated from an extract prepared from the cones of Taxodium distichum, collected in central Ohio. The active subfraction from which all compounds isolated in this study were purified was tested in vivo using Leishmania donovani-infected mice and was found to dose-dependently reduce the parasite burden in the murine livers after iv administration of this crude mixture at 5.6 and 11.1 mg/kg. The structures of 1 and 2 were established by detailed 1D- and 2D-NMR experiments, HRESIMS data, and electronic circular dichroism studies. Compounds 3 and 4 were each fully characterized spectroscopically and also isolated from a natural source for the first time. Compounds 2-16 were tested in vitro against L. donovani promastigotes and L. amazonensis intracellular amastigotes. Compound 2 was the most active against L. amazonensis amastigotes (IC50 = 1.4 μM), and 10 was the most potent against L. donovani promastigotes (IC50 = 1.6 μM). These compounds may be suggested for further studies such as in vivo experimentation either alone or in combination with other Taxodium isolates. PMID:26905523

  14. Sesquiterpene constituents from the essential oils of the liverworts Mylia taylorii and Mylia nuda.

    PubMed

    von Reuss, Stephan H; Wu, Chia-Li; Muhle, Hermann; König, Wilfried A

    2004-08-01

    The essential oils and extracts of Mylia taylorii and M. nuda were investigated by gas chromatography, mass spectrometry, NMR spectroscopy and chemical correlations. Beside several known compounds 13 new constituents including three new carbon skeletons could be identified. Four hydrocarbons with a molecular formula of C15H22 (m/z 202) were identified as myli-4(15)-ene (1), aromadendra-1(10),4(15)-diene (19), aromadendra-4,10(14)-diene (20) and aromadendra-4,9-diene (21). Three oxaspiro-compounds were identified as 7-epi-bourbon-3-en-5,11-oxide (22), guai-3,10(14)-dien-5,11-oxide (23) and guai-3,9-dien-5,11-oxide (24). The absolute configuration of myli-4(15)-en-3-one (5) could be established by chemical correlation. Together with alpha-taylorione (7) the corresponding 6,11-seco-compound taylopyran (25) with a new carbon skeleton was identified which serves as a precursor to taylocyclane (26) and taylofuran (27). Taynudol (28) contains a new carbon skeleton with a cyclobutenyl structure.

  15. Vibrational entropy changes the solid solubility of a random alloy at high temperatures

    NASA Astrophysics Data System (ADS)

    Shulumba, Nina; Hellman, Olle; Raza, Zamaan; Barrirero, Jenifer; Mücklich, Frank; Abrikosov, Igor A.; Odén, Magnus

    2015-03-01

    We have developed a method to accurately and efficiently determine vibrational entropy as a function of temperature and volume for substitutional alloys from first principles. Using Ti1-xAlxN metal alloy as a model system we calculate the isostructural phase diagram by minimization of the free energy, solving the original Gibbs problem of finding its global minimum corresponding to the true equilibrium state of the system. We demonstrate that the vibrational contribution to the free energy has a decisive impact on the calculated phase diagram of Ti1-xAlxN alloy, lowering the maximum temperature for the miscibility gap from 9000 K to 2400 K. The solubility limit of the predicted phase diagram is experimentally verified by local chemical composition measurements of thermally aged Ti50Al50N alloys. DocMASE, SECO Tools AB, SSF RMA 08-0069 and SRL 10-002, VR 2012-4401 and 637-2013-7296, Vinnova M-ERA.net, MC2, (KAW) (Isotopic Control for Ultimate Material Properties).

  16. Using genotoxic and haematological biomarkers as an evidence of environmental contamination in the Ocoa River native fish, Villavicencio-Meta, Colombia.

    PubMed

    Corredor-Santamaría, Wilson; Serrano Gómez, Marlon; Velasco-Santamaría, Yohana María

    2016-01-01

    The studies evaluating the impact of environmental pollution on aquatic organisms have had a growing concern in recent decades. The Ocoa River runs through Villavicencio city, receiving the wastewater produced in the city. To date studies reporting the effect and the consequences of Ocoa River pollution on aquatic organisms inhabiting this water body are unknown. Haematological and genotoxicity biomarkers were evaluated in peripheral blood of two native fish species Astyanax gr. bimaculatus and Aequidens metae during rainy and dry season at three different sites of Ocoa River called Nacimiento (site 1, before entering the city), Centauros (site 2, inside the city), Caño Seco (site 3, after the city). Also, fish from a reference site with little likelihood of contamination were sampled. Alterations such as decrease in erythrocyte count, lymphocytes, haemoglobin concentration and haematocrit percentage, and increased thrombocytes and neutrophils counts, together with nuclear abnormalities in erythrocytes such as increased frequency of micronuclei, lobed, blebbed and notched nuclei and binucleate cells were observed in fish from the site 3, followed by the site 2 in rainy season. These results shown that during rainy season, sites 2 and 3 receive domestic and industrial wastewater leading to genotoxic and haematological changes in the monitored organisms.

  17. Gold nanoparticle-lignan complexes inhibited MCF-7 cell proliferation in vitro: a novel conjugation for cancer therapy.

    PubMed

    Bakar, Filiz; Caglayan, Mehmet G; Onur, Feyyaz; Nebioglu, Serpil; Palabiyik, Ismail M

    2015-01-01

    Nanoparticles, including gold nanoparticles (AuNP), have been used in imaging in cancer treatment and as therapeutic agents and drug delivery vehicles. Particularly lignans, also called phytoestrogens, have strong effects on the treatment of carcinomas due to their antiestrogenic, antiangiogenic and proapoptotic mechanism. The aim of this study is to investigate the antiproliferative effects of three lignans-AuNP conjugates, pinoresinol (PINO), lariciresinol (LARI) and secoisolariciresinol (SECO), on the MCF-7 cell lines. For this purpose, first, thiolated β-cyclodextrin (β-CD) was synthesized to achieve a surface modification of AuNP, and then the β-CD modified AuNP was characterized using the transmission electron microscopy (TEM), UV-Visible and Nuclear Magnetic Resonance (NMR) spectroscopy. Then, the selected lignans were conjugated to the β-CD-modified AuNP, and the antiproliferative effect of these conjugates was monitored. The results suggest that when compared to their non-conjugated forms, the AuNP-bound lignan conjugates prevented the proliferation of the MCF-7 cells significantly. Therefore, these AuNP-conjugated derivatives can be new candidate agents for breast cancer therapy.

  18. [Search of Neurotrophin-mimic Natural Products for Prevention and Treatment of Neurodegenerative Disease].

    PubMed

    Kubo, Miwa

    2015-01-01

    As part of our continuing studies on neurotrophin-mimic active compounds in natural products, we investigated the chemical constituents of the pericarps of Illicium jiadifengpi and the roots of Indonesian ginger Zingiber purpureum, resulting in the isolation of new seco-prezizaane-type sesquiterpenoid 1 and phenylbutenoid dimer 3-4 and two new curcuminoids 5-6. The MeOH extract of I. jiadifengpi was fractionated, leading to the isolation of compound 1. Compound 1 significantly enhanced neurite outgrowth in primary cell cultures of fetal rat cortical neurons. It is noteworthy that compound 1 has potential significantly to promote differentiation of multipotent neural stem cell line (MEB5 cells) into neurons. Additionally, we investigated the MeOH extract of the root of Bangle (Z. purpureum) that exhibited neuritogenesis activity in PC12 cells at 25 μg/mL, resulting in the isolation of neurotrophic phenylbutenoid dimers 3-4 and new compounds 5-6. Compounds 3 and 4 were found not only significantly to induce neurite sprouting of PC12 cells but also to increase the neurite length and number of neurites in primary cultured rat cortical neurons, and also showed protective activity against cell death caused by deprivation of serum. Furthermore, chronic treatment with these compounds enhanced hippocampal neurogenesis in dementia model olfactory bulbectomized (OBX) mice. Compounds 5 and 6 had significant NGF-potentiating effects on PC12 cells whereas compound 5 enhanced prevention of amyloid β (Aβ) 42 aggregation.

  19. Rickettsial infection in ticks infesting wild birds from two eco-regions of Argentina.

    PubMed

    Flores, Fernando Sebastián; Costa, Francisco Borges; Nava, Santiago; Diaz, Luiz Adrián; Labruna, Marcelo Bahia

    2016-01-01

    Several tick-borne Rickettsia species are recognized human pathogens in Argentina. Here we evaluated rickettsial infection in ticks collected on passerine birds during 2011-2012 in two eco-regions of Argentina. The ticks were processed by molecular analysis through polymerase chain reaction (PCR) detection and DNA sequencing of fragments of two rickettsial genes, gltA and ompA. A total of 594 tick specimens (532 larvae and 62 nymphs), representing at least 4 species (Amblyomma tigrinum, Ixodes pararicinus, Haemaphysalis juxtakochi, Haemaphysalis leporispalustris), were evaluated. At least one A. tigrinum larva, collected on Coryphospingus cucullatus in Chaco Seco, was infected with Rickettsia parkeri, whereas at least 12 larvae and 1 nymph of I. pararicinus, collected from Troglodytes aedon, Turdus amaurochalinus, Turdus rufiventris, C. cucullatus and Zonotrichia capensis, were infected with an undescribed Rickettsia agent, genetically related to several rickettsial endosymbionts of ticks of the Ixodes ricinus complex. R. parkeri is a recognized human pathogen in several American countries including Argentina, where a recent study incriminated A. tigrinum as the potential vector of R. parkeri to humans. Birds could play an important role in dispersing R. parkeri-infected A. tigrinum ticks. Additionally, we report for the first time a rickettsial agent infecting I. pararicinus ticks.

  20. Morphological variation in the tropical anole, Anolis casildae (Squamata: Polychrotidae).

    PubMed

    Nicholson, K E; Roberto Ibáñez, D; Jaramillo, C A; Lips, K R

    2001-06-01

    We describe morphological variation (scalation and coloration) observed among eight individuals of the Panamanian lizard species Anolis casildae. This variation was not observed in the holotype and aids in identification of this recently described species (originally described on the basis of a single, male specimen). This species occurs only in the Reserva Forestal Fortuna (Chiriquí Province) and the adjacent Bosque Protector Palo Seco (Bocas del Toro Province) in western Panama. Anolis casildae can be distinguished from all other Panamanian anole species via six features: (1) two enlarged superciliary scales (the first larger than the second); (2) an anterior nasal scale in contact with the rostral scale or separated from the rostral by one scale; (3) 6-8 sublabial scales to the center of the eye; (4) 3-4 scales between the supraobital semicircles; (5) unique coloration (4-6 oblique brown bands interspersed by blue-outlined yellow patches; dewlap is a dirty cream color with broad yellow scale rows irregularly interspersed with smaller emerald green scales) and (6) A. casildae occurs from 1,050 to 1,400 m in the Cordillera Central. We also compare our natural history observations of A. casildae to a similar large anole, A. frenatus, a species which we believe A. casildae to be closely related. PMID:11935926

  1. Relationship between High-Performance Liquid Chromatography Fingerprints and Uric Acid-Lowering Activities of Cichorium intybus L.

    PubMed

    Zhu, Chun-Sheng; Zhang, Bing; Lin, Zhi-Jian; Wang, Xue-Jie; Zhou, Yue; Sun, Xiao-Xia; Xiao, Ming-Liang

    2015-05-22

    This study aimed to explore the spectrum-effect relationships between high-performance liquid chromatography fingerprints and the uric acid-lowering activities of chicory. Chemical fingerprints of chicory samples from ten different sources were determined by high-performance liquid chromatography, and then investigated by similarity analysis and hierarchical clustering analysis. Pharmacodynamics experiments were conducted in animals to obtain the uric acid-lowering activity information of each chicory sample. The spectrum-effect relationships between chemical fingerprints and the uric acid-lowering activities of chicory were established by canonical correlation analysis. The structures of potential effective peaks were identified by liquid chromatography with tandem mass spectrometry. The results showed that a close correlation existed between the spectrum and effect of chicory. Aesculin, chlorogenic acid, chicoric acid, isochlorogenic acid A/B/C and 13,14-seco-stigma5(6),14(15)-diene-3α-ol might be the main effective constituents. This work provides a general model of the combination of high-performance liquid chromatography and uric acid-lowering activities to study the spectrum-effect relationships of chicory, which can be used to discover the principle components responsible for the bioactivity.

  2. [Translation and adaptation to Spanish language of the quality of life questionnaire for celiac people called Canadian Celiac Health Survey].

    PubMed

    Pelegrí, Cristina; Mañes, Jordi; Soriano, Jose Miguel

    2014-10-01

    Introducción: Adaptar y valorar el cuestionario de calidad de vida denominado Canadian Celiac Health Survey (CCHS). Objetivo: Traducir y adaptar en castellano el cuestionario CCHS para poder ser utilizado por la población de habla hispana puesto que se trata de un cuestionario específico para la celiaquía. Método: La adaptación del CCHS, que consta de 76 ítems distribuidos en 11 secciones diferentes, se realizó mediante el método de traducción-retrotraducción y tras ser revisado y consensuado se procedió a realizar una prueba piloto con 25 personas celíacas, de forma individual y por un miembro del grupo de investigación, para valorar la comprensión de los ítems y sus secciones. Las aportaciones fueron introducidas, configurando el cuestionario definitivo. Resultados: La máxima dificultad en la traducción se produjo en la pregunta donde existían principios activos y nombres comerciales de medicamentos, optándose para ello a los comercializados a nivel nacional. Por otro lado, para el estudio piloto del cuestionario se observó un buen valor de la naturalidad de la comprensión con valores comprendidos entre 8,4 y 10,0. Conclusiones: La herramienta específica CHCS permitirá el uso de un cuestionario que pueda ser utilizado por la población de habla hispana en estudios, ensayos clínicos o en la práctica profesional sanitaria cotidiana, permitiendo un mejor conocimiento del estado de salud de los celíacos.

  3. Environmental changes in Sierra Nevada during the last 6 ky BP inferred from solifluction lobes and lake sediments

    NASA Astrophysics Data System (ADS)

    Oliva, M.; Gómez Ortiz, A.; Schulte, L.

    2009-04-01

    Holocene climate variability drove important landscape changes in Sierra Nevada, heightened due to the emplacement of Sierra Nevada at 37°N in southwestern Europe and, therefore, the different crossing influences in this region: geographical Europe/Africa), maritime (Atlantic/Mediterranean), climatic (subtropical high-pressure belt/ mid-latitude westerlies). Despite the existence of several kinds of sedimentary records in Sierra Nevada, only two of them can provide further information about Holocene landscape changes in this massif: solifluction lobes and mountain lakes. The numerous sedimentological changes inferred from terrestrial and aquatic records suggest the proximity of geomorphological processes in the massif of their climate boundaries and the small climate range necessary to carry environmental changes in the summits of the Sierra Nevada. Sierra Nevada holds the highest lakes in Europe, all of them related to a glacial origin. Four lakes were cored in Sierra Nevada, three of them southern exposed (Aguas Verdes, Rio Seco and Rio Seco lagoon) and only one with northern orientation (San Juan lagoon). Sedimentological properties of these cores assert evidences of different phases of coarse-grained inputs into the lakes, with low organic matter proportion and high mineral contents. These pulses correspond to geomorphic periods with enhanced slope instability, interfingered in phases with lower sediment transfer onto the lakes. These relative stable periods show a fine-grained texture with less mineral fraction and increases in the organic composition of the sediments. The similar evolution of the C/N ratio and Corg contents reflects the low productivity of these oligotrophic lakes and the terrestrial origin of the organic matter present in their sediments; both proxies also confirm a general pattern characterized in Sierra Nevada by an arid trend since the HWP, when the headwaters of the highest catchments stored a denser vegetation cover. We report an

  4. Meta-Analysis of Attitudes toward Damage-Causing Mammalian Wildlife

    PubMed Central

    KANSKY, RUTH; KIDD, MARTIN; KNIGHT, ANDREW T

    2014-01-01

    íferos Silvestres Causantes de Daños Resumen Muchas poblaciones de mamíferos amenazados persisten fuera de áreas protegidas formales y su supervivencia depende de la buena voluntad de las comunidades que coexisten con ellos. Un entendimiento de las posturas, y específicamente de la tolerancia, de los individuos y las comunidades y los factores que los determinan es fundamental para diseñar estrategias que alivien el conflicto humano – vida silvestre. Llevamos a cabo un meta-análisis para identificar los factores que afectaron las posturas hacia cuatro grupos de mamíferos terrestres. Los elefantes (65%) provocaron las posturas más positivas. Los siguieron los primates (55%), los ungulados (53%) y los carnívoros (44%). Los residentes urbanos presentaron las posturas más positivas (80%), seguidos por los granjeros comerciales (51%) y los granjeros comunales (26%). Un índice de tolerancia a los daños mostró que la tolerancia humana a los ungulados y primates fue proporcional a la probabilidad de experimentar daños mientras que los elefantes provocaron niveles de tolerancia más altos de lo esperado y los carnívoros provocaron niveles de tolerancia más bajos de lo esperado. Contrario a la sabiduría convencional, experimentar daños no fue siempre el factor dominante para determinar las posturas. Los granjeros comunales tuvieron una baja probabilidad de ser positivos hacia los carnívoros independientemente de la probabilidad de experimentar daños, mientras que los granjeros comerciales y los residentes urbanos tuvieron mayor probabilidad de ser positivos hacia los carnívoros independientemente de los daños. Los residentes urbanos tuvieron mayor probabilidad de ser positivos hacia los ungulados, los elefantes y los primates cuando la probabilidad de daños fue baja, pero no cuando fue alta. Los granjeros comerciales y comunales tuvieron una mayor probabilidad de ser positivos hacia los ungulados, los primates y los elefantes independientemente de la probabilidad de

  5. [In Process Citation].

    PubMed

    Molina Recio, Guillermo; Moreno Rojas, Rafael; García Rodríguez, María; Vaquero Abellán, Manuel

    2016-02-16

    Introducción: un gran número de encuestas nutricionales en Perú han identificado la magnitud y la ubicación de los diferentes tipos de desnutrición, siendo la forma crónica la más prevalente. Sin embargo, aunque las tasas pueden considerarse alarmantes (aún más en las zonas rurales), sólo un trabajo contiene información sobre las características de la ingesta, usando recordatorios de 24 horas (R24). Es decir, se carece de otros sistemas de estudio centrados en conocer las características gastronómicas de sus regiones y la biodisponibilidad de los alimentos, con el fin de localizar el origen de esta situación en cada área y proponer soluciones verdaderamente eficaces y eficientes.Objetivo: determinar el valor nutricional de los platos principales consumidos por los residentes de un barrio pobre de la Amazonía Peruana, para identificar las causas de la pérdida de un estado nutricional saludable.Métodos: noventa y ocho participantes completaron tres R24. Basándonos en estos datos, se seleccionaron los 25 platos más comúnmente consumidos y evaluamos su composición nutricional. Tomamos nota de las recetas, pesos y medidas caseras. Además, se observó la preparación y cocción. La composición nutricional media de cada plato se calculó por 100 g utilizando el software Nutriplato 4.6. También se calcularon lasganancias o pérdidas derivadas de los tratamientos culinarios.Resultados: dentro de los platos basados en la leche, el de más alta densidad de energía es el mingado de arroz. En el grupo de los pescados, la mayor cantidad de energía es aportada por el pescado frito, mientras que en las recetas a base de carne, las más energéticas son el tallarín con pollo, la res asada y el cerdo frito. Como platos preparados, el juane tiene la más alta densidad de energía de todas las recetas. Dentro de las guarniciones, aquellas que utilizan los plátanos como el ingrediente principal, el plátano frito y el madurito, son las más energ

  6. [In Process Citation].

    PubMed

    Molina Recio, Guillermo; Moreno Rojas, Rafael; García Rodríguez, María; Vaquero Abellán, Manuel

    2016-01-01

    Introducción: un gran número de encuestas nutricionales en Perú han identificado la magnitud y la ubicación de los diferentes tipos de desnutrición, siendo la forma crónica la más prevalente. Sin embargo, aunque las tasas pueden considerarse alarmantes (aún más en las zonas rurales), sólo un trabajo contiene información sobre las características de la ingesta, usando recordatorios de 24 horas (R24). Es decir, se carece de otros sistemas de estudio centrados en conocer las características gastronómicas de sus regiones y la biodisponibilidad de los alimentos, con el fin de localizar el origen de esta situación en cada área y proponer soluciones verdaderamente eficaces y eficientes.Objetivo: determinar el valor nutricional de los platos principales consumidos por los residentes de un barrio pobre de la Amazonía Peruana, para identificar las causas de la pérdida de un estado nutricional saludable.Métodos: noventa y ocho participantes completaron tres R24. Basándonos en estos datos, se seleccionaron los 25 platos más comúnmente consumidos y evaluamos su composición nutricional. Tomamos nota de las recetas, pesos y medidas caseras. Además, se observó la preparación y cocción. La composición nutricional media de cada plato se calculó por 100 g utilizando el software Nutriplato 4.6. También se calcularon lasganancias o pérdidas derivadas de los tratamientos culinarios.Resultados: dentro de los platos basados en la leche, el de más alta densidad de energía es el mingado de arroz. En el grupo de los pescados, la mayor cantidad de energía es aportada por el pescado frito, mientras que en las recetas a base de carne, las más energéticas son el tallarín con pollo, la res asada y el cerdo frito. Como platos preparados, el juane tiene la más alta densidad de energía de todas las recetas. Dentro de las guarniciones, aquellas que utilizan los plátanos como el ingrediente principal, el plátano frito y el madurito, son las más energ

  7. [Mediterranean and Western dietary patterns in adult population of a Mediterranean area; a cluster analysis].

    PubMed

    Ciprián, Daniel; Navarrete-Muñoz, Eva Ma; Garcia de la Hera, Manuela; Giménez-Monzo, Daniel; González-Palacios, Sandra; Quiles, Joan; Vioque, Jesús

    2013-01-01

    Antecedentes/objetivo: El objetivo de este estudio ha sido identificar patrones dietéticos a partir de los datos recogidos en la Encuesta de Nutrición y Salud de la Comunidad Valenciana realizada sobre una muestra representativa de población adulta y explorar los posibles factores asociados a los patrones identificados. Metodología: Un total de 1.803 individuos adultos (973 mujeres) participaron en la encuesta de Nutrición y Salud realizada en 1994 en la Comunidad Valenciana. La dieta fue evaluada mediante cuestionario de frecuencia alimentaria (CFA) validado de 93 ítems alimentarios. Las ingestas de alimentos se ajustaron por mil calorías y se crearon 26 grupos de alimentos usando valores estandarizados (z-scores) para la identificación de patrones dietéticos por el método análisis de k-medias prefijando 3 clúster. Se usó regresión logística multinomial múltiple para explorar la asociación entre patrones y variables sociodemográficas, antropométricas y de estilos de vida. Resultados: Se identificaron tres patrones dietéticos denominados como Prudente, Mediterráneo y Occidental. El patrón Prudente (57,2%) se caracterizó por un consumo intermedio de los principales grupos de alimentos; el Mediterráneo (29,1%) destacó por un elevado consumo de frutas, verduras y pescado; y el Occidental (13,7%) por un alto consumo de carnes rojas, embutidos, platos preparados, croquetas, bebidas azucaradas, dulces, chocolates y bebidas alcohólicas. El patrón Mediterráneo presentó las mayores puntuaciones para varios índices de calidad alimentaria analizados y definidos a priori en la literatura. Usando como referencia el patrón Mediterráneo, los que seguían un patrón Occidental fueron significativamente más jóvenes, un mayor número de hombres y fumadores; los que seguían un patrón Prudente presentaron un mayor número de hombres, no practicaban actividad física regular y menor consumo de alcohol. Conclusión: De los tres patrones diet

  8. Nutritional status influences the length of stay and clinical outcomes in patients hospitalized in internal medicine wards.

    PubMed

    Ordoñez, Ana Manuela; Madalozzo Schieferdecker, Maria Eliana; Cestonaro, Talita; Cardoso Neto, João; Ligocki Campos, Antônio Carlos

    2013-01-01

    Objetivo: Vincular el estado nutricional (EN) con la evolución clínica y la duración de la estancia de los pacientes ingresados en las clínicas médicas de un hospital universitario. Métodos: Estudio observacional retrospectivo en el que los datos analíticos se obtuvieron de los pacientes ingresados durante el período de un año. Para la evaluación del EN se utilizaron: la valoración global subjetiva (VGS), el índice de masa corporal (IMC), el pliegue cutáneo triciptal (PCT), la circunferencia muscular del brazo (CMB) y el diagnostico del estado nutricional por la combinación de métodos (VGS, medidas de antropometría y bioquímicas). El análisis estadístico se realizó con el poder de confianza del 95% (p < 0,05). Para las categorías de comparación se utilizó chi-cuadrado. Para examinar la asociación entre la duración de la estancia y variables relacionadas con el EN se utilizaron Mann-Whitney y Kruskal-Wallis con comparaciones múltiples. Resultados: De los 396 sujetos estudiados 57,8% eran adultos. Ser mayor se asoció con la presencia de hipertensión arterial (p <0,001), diabetes mellitus (p = 0,003) y requerir cambios en la consistencia de la dieta (p = 0,003). Al final de la evaluación el 45,7% eran desnutridos. Presentar disminución de la ingesta de alimentos (p = 0,01), malnutrición según el SGA (p = 0,02) y la CMB (p = 0,03) se asoció con mortalidad. Estuvieron más tiempo hospitalizados los pacientes con nivel terciario de atención (p = 0,01), disminución de la ingestión de alimentos (p = 0,001), que murieron (p = 0,004), con un diagnóstico de desnutrición por VGS (p = 0,001) y por la combinación de métodos (p = 0,001). Conclusión: pacientes desnutridos según VGS y con disminución de la ingestión de alimentos al comienzo de la hospitalización se mantuvieron más tiempo en el hospital y tuvieron peores resultados clínicos (mayor número de muertes). El diagnóstico de la desnutrición por CMB también se relacion

  9. [Breastfeeding for the prevention of overweight and obesity in children and teenagers; systematic review].

    PubMed

    Aguilar Cordero, María José; Sánchez López, Antonio Manuel; Madrid Baños, Nayra; Mur Villar, Norma; Expósito Ruiz, Manuela; Hermoso Rodríguez, Enrique

    2014-11-30

    Introducción: La Lactancia materna es una práctica recomendada desde las instituciones nacionales e internacionales debido a los beneficios que reporta para la salud, tanto del lactante como de la madre. En la actualidad, el sobrepeso y la obesidad conllevan una mayor morbilidad en los diferentes períodos de la vida. Objetivo: El objetivo de esta revisión sistemática es conocer las características de la lactancia materna en la prevención del sobrepeso y la obesidad en la infancia. Método: Se ha efectuado una búsqueda sistemática y se han seleccionado 113 artículos: 20 meta-análisis y revisiones, 6 artículos originales de ensayos clínicos, 42 estudios de cohorte o longitudinales, 19 estudios correlaciónales de muestra amplia, 24 descriptivos y 2 libros. Resultados: Según los artículos analizados, existe una relación causal entre la lactancia materna y la prevención de la obesidad infantil. Discusión/conclusión: En los diferentes estudios se ha podido verificar que los máximos beneficios de la lactancia materna se obtienen cuando su duración es mayor de 6 meses y se prolonga hasta los dos años, apoyada con otros alimentos. Otros estudios muestran que la lactancia materna es eficaz en la prevención de la obesidad, aunque su duración sea breve. También es importante que la alimentación complementaria se introduzca pasados los 6 meses de vida, para disminuir el riesgo de alergia a los alimentos y prevenir así la obesidad. Igualmente, se han relacionado con la obesidad infantil el peso de la madre durante el embarazo, el peso del niño al nacer, el tabaquismo materno y el nivel socioeconómico.

  10. Differences in food intake and nutritional habits between Spanish adolescents who engage in ski activity and those who do not.

    PubMed

    Mariscal-Arcas, Miguel; Monteagudo, Celia; Hernandez-Elizondo, Jessenia; Benhammou, Samira; Lorenzo, M Luisa; Olea-Serrano, Fatima

    2014-10-31

    Antecedentes: El aumento de la obesidad entre los adolescentes en países desarrollados puede ser consecuencia de malos hábitos alimentarios y falta de actividad. Objetivo: Determinar las diferencias en la ingesta de alimentos, hábitos nutricionales e índice de masa corporal entre adolescentes españoles que practican esquí y los que no lo hacen. Métodos: Una muestra de 300 adolescentes españoles de 10 a 18 años completó una encuesta que incluyó variables sociodemográficas, un cuestionario de frecuencia de consumo de alimentos, recordatorio de 24h y un cuestionario de actividad física. Se utilizaron test de comparación paramétricos y no paramétricos para comparar los resultados entre adolescentes que practican (SP) y no practican (N-SP) esquí, en función al sexo. Resultados: Los adolescentes SP dedicaron más de 4h diarias a la realización de actividad física mientras que los adolescentes N-SP dedicaron menos de 1 hora diaria a la actividad física. No se encontraron diferencias significativas en la ingesta de nutrientes o los hábitos nutricionales entre adolescentes SP y N-SP. La ingesta de proteínas y lípidos de ambos grupos estuvo por encima de los niveles recomendados. El sobrepeso fue más frecuente entre adolescentes N-SP. El análisis de regresión logística mostró que el mantenimiento de un peso normal se ve favorecido por la práctica del esquí, el consumo de bebidas sin azúcar y la suplementación con vitaminas/minerales y se asoció negativamente con la insatisfacción con el peso corporal, el consumo de suplementos nutricionales distintos a vitaminas o minerales y el consumo de aperitivos. Conclusiones: La dieta de esta población adolescente fue desequilibrada. La participación en la actividad física parece ser un factor clave en el mantenimiento de un índice de masa corporal saludable.

  11. Changing dietary habits among Akwen Xerente.

    PubMed

    Rocha, Tatiana Evangelista da Silva; Silva, Reijane Pinheiro da; Nascimento, Maira Messias do

    2016-06-01

    The research aimed to identify the current feed of Xerente people in Indian villages Porteira and Funil in the city of Tocantinia / TO. It was used a qualitative ethnographic approach. Conducted from September 2013 to August 2014. The data were presented in a diary, through participant observation of food practices with the guidance of a script. A process of dietary change that permeates the culture of this people is taking place. Factors such as the deficit in the planting gardens, the recent arrival of energy, and therefore the technology has allowed access to processed foods. But some families still maintain the farming of cassava, yam, and beans. The main animals that are hunted in the village are peccary, deer and armadillo. It was possible to point which foods are inserted in the Xerente feed and factors related to this situation. A pesquisa objetivou identificar a alimentação atual do povo Xerente, nas aldeias indígenas Porteira e Funil, no município de Tocantínia / TO. Utilizou-se uma abordagem etnográfica qualitativa. Realizada entre setembro de 2013 a agosto de 2014. Os dados foram descritos através de um diário de campo, por meio da observação das práticas alimentares com a orientação de um roteiro. Está ocorrendo um processo de mudança alimentar na cultura deste povo. Fatores como o déficit no plantio das roças, a chegada da energia, e consequentemente a tecnologia, permitiu o acesso a alimentos industrializados. Mas algumas famílias ainda mantem o cultivo de mandioca, inhame, feijão andu. Os principais animais que são caçados na aldeia são caititu, veado e tatu. Foi possível encontrar a presença de alimentos industrializados inseridos na alimentação do Xerente e isso tem provocado alterações nos hábitos desse povo.

  12. NUTRITIONAL AND METABOLIC ASSESSMENT IN OVERWEIGHT PATIENTS WITH AND WITHOUT HYPERPROLACTINEMIA CAUSED BY PROLACTINOMA.

    PubMed

    Breyer Freitas, Bruna; Rothen, Renata Elisabeth; Zeni, Débora; Garcia Soares Leães, Carolina; Costa Oliveira, Miriam; Michielin Busnello, Fernanda; Fernanda Semmelmann Pereira-Lima, Júlia

    2015-11-01

    Introducción: los prolactinomas son adenomas hipofisarios que expresan y secretan prolactina. Estos pacientes tienen sobrepeso y el mecanismo está en estudio. Objetivos: evaluar el estado nutricional y metabólico de los pacientes con sobrepeso con y sin hiperprolactinemia causada por prolactinoma y compararlos. Materiales y métodos: es un estudio transversal con pacientes con índice de masa corporal (IMC) ≥ 25 kg/m2 con y sin prolactinoma: 1) 20 normoprolactinémicos (NPrl) con prolactinoma; 2) 23 hiperprolactinémicos (HPrl) con prolactinoma; 3) 28 controles sin prolactinoma o alteraciones en los niveles de prolactina. Evaluados a través de estudios antropométricos evaluación dietética y bioquímica. Resultados: de los 71 pacientes evaluados, la mayoría eran mujeres obesas con macroprolactinomas. Los tres grupos tenían dietas con baja ingesta de calorías y ácidos grasos monoinsaturados (MUFA), el grupo NPrl tenía ingesta baja en carbohidratos (CHO) y alta en lípidos (LIP) y ácidos grasos saturados (SFA), y los grupos NPrl y HPrl tenían ingesta apropiada de ácidos grasos poliinsaturados (PUFA). El grupo HPrl tenía el colesterol sérico por encima del valor recomendado, mientras el colesterol HDL estaba por debajo del valor recomendado en la mayoría de los pacientes. No se encontraron diferencias estadísticamente significativas en las variables antropométricas y bioquímicas entre los grupos. Conclusiones: la mayoría de los pacientes con prolactinomas y los controles son obesos y metabólicamente similares, independientemente de los niveles de prolactina. Todos los grupos presentaron baja ingesta de calorías y de ácidos grasos monoinsaturados. Proteínas, LIP, SFA y colesterol fueron significativamente diferentes entre los grupos, el grupo de NPrl ingiere menos cantidad de proteína y mayor de grasa. La mayoría de los pacientes manifiestan picar entre las comidas y cambios en el consumo de alimentos los fines de semana. Este es el primer

  13. [In Process Citation].

    PubMed

    Petter da Silva, Fhaira; Beatriz Dallepiane, Loiva; Ramos Kirsten, Vanessa; Maria Kirchner, Rosane

    2016-01-01

    Introducción: la esperanza de vida está aumentando y convirtiéndose en un fenómeno característico de los países desarrollados y, cada vez más, de los países en desarrollo, como Brasil. El proceso de envejecimiento produce cambios en algunas funciones fisiológicas, como la pérdida del olfato o gusto o pérdida de apetito, entre otros, que terminan alterando la ingesta de alimentos de estos individuos.Objetivos: este estudio tuvo como objetivo evaluar el consumo de alimentos de los ancianos y de los ancianos más longevos en una ciudad del sur de Brasil.Métodos: un estudio transversal realizado mediante visitas a domicilio en Palmeira das Missões - RS, Brasil. Los datos sociodemográficos, antropométricos y dietéticos fueron recogidos a través de cuestionarios y recordatorio de 24 horas. La adecuación de nutrientes se evaluó de acuerdo con las ingestas de referencia en la dieta. Los datos fueron analizados utilizando el software SPSS 18.0.Resultados: el estudio incluyó a 424 adultos mayores, el 84.4% (n = 358) de ellos menores de 80 años y el 15.6% (n = 66) con más de 80 años. La ingesta de energía y proteínas fue insuficiente tanto para jóvenes adultos como para los más ancianos. El consumo de vitaminas y minerales ha sido insuficiente en todos los adultos mayores a excepción del hierro, que presentaba una ingesta excesiva. Hubo una diferencia estadísticamente significativa entre las personas de edad y mayores sólo en cuanto al consumo de lípidos y vitamina B12. Conclusión: la mayoría de los estudios con personas mayores corrobora los resultados obtenidos en este artículo. Una ingesta inadecuada de nutrientes puede dar lugar a deficiencias nutricionales y, por lo tanto, a cambios fisiológicos y patológicos que pondrían en peligro la capacidad funcional de los ancianos. El consumo de energía y de macronutrientes resultó insuficiente tanto para los ancianos como para los ancianos más longevos. Además, el consumo de vitaminas y

  14. [Not Available].

    PubMed

    Perales-García, Aránzazu; Estévez-Martínez, Isabel; Urrialde, Rafael

    2016-07-12

    Introducción: la hidratación se define como el aporte de agua proveniente de alimentos y bebidas. Su estudio constituye desde hace unos años un área en sí misma dentro de la nutrición, que ha supuesto que en 2010 la European Food Safety Authority (EFSA) aprobara las recomendaciones de ingesta de agua; pero el estudio del estado de hidratación implica un elevado nivel metodológico que presenta ciertos desafíos. Objetivo: ofrecer una visión general de los principales problemas metodológicos en estudios sobre el estado de hidratación. Material y métodos: revisión de la bibliografía científica existente. Resultados: los principales problemas metodológicos presentes son: selección de la muestra (ámbito de investigación y diseño muestral), selección del método de evaluación del estado de hidratación (técnicas de dilución, impedancia bioeléctrica, indicadores plasmáticos y urinarios, cambios en la composición corporal, pérdidas de agua y síntomas clínicos), selección del método de valoración de la ingesta de agua (biomarcadores, cuestionarios, programas informáticos, uso de smartphones, registro 24 h, historia dietética y frecuencia de consumo de alimentos), así como sus principales fuentes dietéticas. Conclusiones: el estado de hidratación debe ser entendido como un modelo rutinario, de frecuencia diaria y variable en función de la edad, sexo, actividad física y condiciones ambientales; por todo ello es de especial importancia un correcto diseño metodológico capaz de recoger estos matices.

  15. Mites and the implications on human health.

    PubMed

    Vogel, Patrícia; Bosco, Simone Morelo Dal; Ferla, Noeli Juarez

    2014-01-01

    Introducción: La infestación por ácaros de productos almacenados es de gran importancia económica y de salud pública, con consecuencias para la salud humana. Objetivos: Describir las especies de ácaros asociados a los productos alimenticios almacenados y que causan consecuencias para la salud humana, así como para analizar la pérdida de la calidad y la composición nutricional de los alimentos infestados. Método: Revisión de la literatura en LILACS-BIREME, SciELO y MEDLINE bases de datos de las publicaciones en Inglés, portugués y español con los descriptores “ácaros”, “alimentos”, “ácaros de almacenamiento”, “los ácaros del producto de su tienda”, “los ácaros del polvo”, “calidad control “,” alimentos de calidad “,” composición química “,” química “,” alérgenos “y” salud “. Se identificaron 80 artículos, pero sólo 55 estaban relacionados con los objetivos del estudio. Dieciséis referencias fueron mencionados en los artículos que se encontraron después de verificado su relevancia. Resultados y discusión: La actividad de los ácaros causan pérdida de calidad sanitaria, el peso y la composición nutricional de los productos infestados, con grandes pérdidas económicas en la industria del grano. La inhalación, ingestión o contacto de los ácaros, subproductos del metabolismo y las heces pueden sensibilizar individuos susceptibles y causar asma, rinitis alérgica, dermatitis de contacto, enteritis y conducir a la anafilaxis. El control de la temperatura y la humedad es esencial para el control de ácaros, así como una mejor conservación y la higiene de las unidades de almacenamiento de grano.

  16. IN VITRO AND IN VIVO ANTIOXIDANT ACTIVITY OF BURITI FRUIT (MAURITIA FLEXUOSA L.F.).

    PubMed

    da Rocha Romero, Amanda Batista; de Carvalho e Martins, Maria do Carmo; Moreira Nunes, Paulo Humberto; Ravenna Trindade Ferreira, Nayara; da Silva Brito, Ana Karolinne; Marinho da Cunha, Polliana Farias; de Lima, Alessandro; de Assis, Regina Célia; Moreira Araújo, Eva

    2015-11-01

    Introducción: estudios previos han demostrado que la fruta Burití (Mauritia flexuosa L.f). posee una alta concentración de ácidos grasos monoinsaturados, carotenoides, polifenoles y ácido ascórbico. Este estudio evaluó la actividad antioxidante in vitro e in vivo del Burití. Métodos: fueron determinadas la composición química, el contenido de compuestos fenólicos y de carotenoides tanto de la pulpa del Burití como de las raciones de alimento. La actividad antioxidante in vitro fue analizada utilizando el ensayo del radical 2,2-difenil-1-picrilhidrazil (DPPH). Ratas Wistar (21 días de edad) fueron asignadas al azar (n = 10) en grupos controles y grupos experimentales (alimentación enriquecida con pulpa de Burití). Después de 60 días, la actividad antioxidante in vivo se evaluó mediante la actividad enzimática de la catalasa y grupos sulfhidrílo no proteico (NPSH) en el hígado, y se cuantificó el malondialdehído (MDA) en plasma y tejidos. Resultados: la pulpa del Burití presentó alto contenido de ácido graso oleico (73,3%), compuestos fenólicos (192 ± 0,3 mg/100 g) y carotenoides (23,9 ± 0,5 mg/100 g), así como una elevada actividad antioxidante in vitro. La dieta enriquecida tenía mayor contenido de fenoles y carotenoides, y una mayor actividad antioxidante en comparación con la alimentación estándar (p < 0,05). No se observaron diferencias entre los grupos con respecto a la actividad de la catalasa en el hígado y las concentraciones de MDA en plasma, hígado y riñones. Las ratas macho del grupo experimental tuvieron concentraciones hepáticas más altas de NPSH (p < 0,05). Conclusión: estos resultados pueden corroborar la hipótesis de que la fruta Burití es un alimento funcional antioxidante y su consumo es conveniente en una dieta nutricionalmente equilibrada.

  17. [Nutritional analysis of breakfast on rising and mid-morning snack in a college population].

    PubMed

    Durá Travé, T

    2013-01-01

    Objetivo: Realizar un estudio descriptivo del modelo de desayuno de una población universitaria y analizar su aporte energético y de nutrientes en relación con los requerimientos nutricionales establecidos. Material y métodos: Registro de consumo de alimentos durante la mañana (desayuno/almuerzo) de un día lectivo a una muestra de 740 universitarios (286 varones y 454 mujeres) con edades comprendidas entre 18 y 25 años. De cada encuestado se registraba sexo, edad, peso, talla e índice de masa corporal y tipo de residencia. Se han calculado las ingestas porcentuales de nutrientes en relación con las ingestas recomendadas (%IR). Resultados: El 98,6% desayunaba y el 54,2% almorzaba diariamente, y el 53.5% realizaba ambas ingestas. Lácteos (92,6%), cereales (58,8%) y dulces (57,9%) en el desayuno, y cereales (46,6%), frutas (40,7%) y embutidos (34,9%) en el almuerzo eran los alimentos más habituales. El %IR de la ingesta calórica (desayuno/almuerzo) era del 24,4% en varones y del 24,6% en mujeres (NS). El %IR de la ingesta de colesterol (desayuno:/almuerzo) era de 38,2% en varones y del 23,9% en mujeres (p < 0,05). En el desayuno los %IR de minerales y vitaminas eran significativamente superiores (p < 0,05) respecto a los del almuerzo. Conclusiones: Este modelo de desayuno/almuerzo difería del prototipo dietético saludable con un consumo excesivo de dulces, bollería y repostería (desayuno) y carnes y derivados (almuerzo). La mitad de los encuestados no almorzaban y su ingesta calórica matutina estaba por debajo de lo recomendado. Tratándose de estudiantes universitarios inquieta el efecto potencialmente negativo que pudiera tener sobre el rendimiento académico.

  18. [STRATEGIES TO IMPROVE THE NUTRITIONAL AND HEALTH CHARACTERISTICS OF MEAT PIE OF MURCIA].

    PubMed

    Ruiz-Cano, Domingo; Zamora, Salvador; Frutos, María José; López-Jiménez, José Ángel; Pérez-Llamas, Francisca

    2015-12-01

    Objetivos: mejorar la composición nutritiva y las características saludables del pastel de carne de Murcia (PCM), manteniendo sus apreciadas cualidades organolépticas y el diseño de un PCM funcional, mediante la adición de un ingrediente natural rico en fuctooligosacáridos. Métodos: mediante cambios relacionados con el tipo y cantidad de algunos de sus ingredientes se han elaborado diversas formulaciones del PCM (PCM saludable y PCM funcional). Se ha determinado la composición nutritiva, el valor calórico, el perfil de ácidos grasos y la calidad de la grasa. Además, se han valorado diversos atributos sensoriales y la aceptación global utilizando una escala descriptiva hedónica de nueve puntos. Resultados y discusión: el PCM saludable presenta un menor contenido de energía (15,4%), grasa total (39%), grasa saturada (48%) y sal (45%), así como una disminución de la potencial capacidad aterogénica (27%), trombogénica (30%) e hipercolesterolémica (30%) que el PCM tradicional. De las cuatro cantidades ensayadas (2,5, 5, 10 y 15%), solo la sustitución del 2,5 y 5% del ingrediente funcional no disminuyeron la aceptación global del PCM funcional, en comparación con el PCM tradicional. Conclusiones: los cambios en la formulación han mejorado la composición nutritiva y las características saludables del PCM tradicional, manteniendo sus cualidades organolépticas. El PCM funcional, elaborado con el ingrediente funcional al 5%, representa una mejora factible en las características funcionales del alimento estudiado. Estas estrategias contribuyen a mantener este tipo de alimentos tradicionales y a evitar la pérdida en la cultura, identidad y herencia gastronómica de España en general y de la Región de Murcia en particular.

  19. [Characterization and nutritional value of a food artisan: the meat pie of Murcia].

    PubMed

    Ruiz-Cano, Domingo; Pérez-Llamas, Francisca; López-Jiménez, José Ángel; González-Silvera, Daniel; Frutos, Maria José; Zamora, Salvador

    2013-01-01

    Objetivos: Describir las características de un producto típico de la gastronomía murciana, determinar su valor nutritivo y energético, analizar su perfil de ácidos grasos y la calidad de su grasa. Material y métodos: Se estudiaron 24 muestras de Pastel de carne de Murcia, procedentes de los seis establecimientos de mayor venta en la Región. (Cuatro unidades por establecimiento). Mediante los métodos oficiales de análisis de alimentos se determinaron los contenidos de humedad, proteína, grasa, carbohidratos, fibra y minerales, el valor energético, el perfil de ácidos grasos (Método de Folch et al. 1957) y la calidad de la grasa. Todos los análisis se realizaron por triplicado. Resultados y discusión: El peso medio fue de 192,3 ± 11,8 g, y en él se diferenciaron tres partes (base, relleno y tapa de hojaldre). Todos sus ingredientes fueron materias primas naturales: harina de trigo, manteca de cerdo, carne picada de ternera, rodajas de huevo cocido y de chorizo, agua y especias (sal, pimienta, ajo, pimentón y nuez moscada). La mayoría de sus atributos organolépticos son debidos al tipo y cantidad de la grasa, manteca de cerdo. El resto de atributos los aporta la combinación de los otros ingredientes y particularmente la formulación de las especias. Por su contenido en proteínas (11,0%), este producto puede sustituir a otros platos a base de carne, e incorporarlo a una dieta equilibrada, pero teniendo en cuenta su contenido en grasa (17,3%) y su aporte energético (317 kcal/100 g). A diferencia de otros muchos productos actuales de pastelería, éste no contiene ácidos grasos trans. Conclusiones: El estudio revela que el producto analizado sigue siendo, en el momento actual, un alimento artesanal, y ofrece información fiable y representativa del valor nutritivo y energético del pastel de carne de Murcia, un producto típico de la gastronomía de la Región de Murcia.

  20. [Validity and reproducibility of a food frequency questionnaire to assess lipid and phytochemical intake].

    PubMed

    Perovic, Nilda R; Defago, Maria D; Aguinaldo, Anabel; Joekes, Silvia; Actis, Adriana B

    2015-01-01

    Antecedentes: estudios epidemiológicos sugieren que el consumo de ciertos alimentos puede reducir el riesgo de enfermedades no transmisibles (ENT). Objetivo: analizar la validez y reproducibilidad de un cuestionario de frecuencia de consumo alimentario (FFQ) destinado a evaluar la ingesta de lípidos y fitoquímicos. Material y métodos: el FFQ fue administrado a 45 personas de ambos sexos, con edades entre 20 y 72 años de edad, residentes en Córdoba, Argentina. Incluyó 257 preguntas referidas a los alimentos, su frecuencia de consumo y tamaño de la porción. Se consideró la estacionalidad para el consumo de frutas y verduras. El cuestionario se aplicó en dos períodos diferentes (FFQ1 y FFQ2) con un intervalo de seis meses y se acompañó por un recordatorio de 24 horas (24HDR) utilizado en tres periodos de tiempo. Se realizó la estimación de: ingesta promedio FFQ1-FFQ2 y 24HDR-FFQ2, diferencia de medias, desviación absoluta de diferencias de medias, prueba de los rangos con signo de Wilcoxon y test de correlación de Spearman. Resultados: los coeficientes de correlación para FFQ1-FFQ2 variaron de 0,52 para el ácido graso eicosapentanoico 20:5 n3 (EPA) a 0,89 para ácido graso butírico 4:0 (p<0,05). Para 24HDR-FFQ2, los valores de correlación oscilaron entre 0,19 para licopeno y 0,93 para el EPA (p <0,05). Conclusión: el análisis realizado mostró una validez aceptable y reproducibilidad del FFQ, permitiendo así que sea utilizado en investigaciones sobre ingesta de lípidos y fitoquímicos y el riesgo de ENT.

  1. [In Process Citation].

    PubMed

    Petter da Silva, Fhaira; Beatriz Dallepiane, Loiva; Ramos Kirsten, Vanessa; Maria Kirchner, Rosane

    2016-02-16

    Introducción: la esperanza de vida está aumentando y convirtiéndose en un fenómeno característico de los países desarrollados y, cada vez más, de los países en desarrollo, como Brasil. El proceso de envejecimiento produce cambios en algunas funciones fisiológicas, como la pérdida del olfato o gusto o pérdida de apetito, entre otros, que terminan alterando la ingesta de alimentos de estos individuos.Objetivos: este estudio tuvo como objetivo evaluar el consumo de alimentos de los ancianos y de los ancianos más longevos en una ciudad del sur de Brasil.Métodos: un estudio transversal realizado mediante visitas a domicilio en Palmeira das Missões - RS, Brasil. Los datos sociodemográficos, antropométricos y dietéticos fueron recogidos a través de cuestionarios y recordatorio de 24 horas. La adecuación de nutrientes se evaluó de acuerdo con las ingestas de referencia en la dieta. Los datos fueron analizados utilizando el software SPSS 18.0.Resultados: el estudio incluyó a 424 adultos mayores, el 84.4% (n = 358) de ellos menores de 80 años y el 15.6% (n = 66) con más de 80 años. La ingesta de energía y proteínas fue insuficiente tanto para jóvenes adultos como para los más ancianos. El consumo de vitaminas y minerales ha sido insuficiente en todos los adultos mayores a excepción del hierro, que presentaba una ingesta excesiva. Hubo una diferencia estadísticamente significativa entre las personas de edad y mayores sólo en cuanto al consumo de lípidos y vitamina B12. Conclusión: la mayoría de los estudios con personas mayores corrobora los resultados obtenidos en este artículo. Una ingesta inadecuada de nutrientes puede dar lugar a deficiencias nutricionales y, por lo tanto, a cambios fisiológicos y patológicos que pondrían en peligro la capacidad funcional de los ancianos. El consumo de energía y de macronutrientes resultó insuficiente tanto para los ancianos como para los ancianos más longevos. Además, el consumo de vitaminas y

  2. [Wholegrain cereals and sanitary benefits].

    PubMed

    Ortega, Rosa M; Aparicio Vizuete, Aránzazu; Jiménez Ortega, Ana Isabel; Rodríguez Rodríguez, Elena

    2015-07-18

    Objetivos: las guías alimentarias para conseguir una alimentación correcta establecen como aconsejable tomar tres o más raciones de cereales integrales de grano completo al día. Sin embargo, la norma es poco conocida en nuestro entorno, afectando el incumplimiento a la práctica totalidad de la población. Por ello, el objetivo de la presente revisión es analizar los beneficios nutricionales y sanitarios asociados al consumo de cereales de grano completo y las posibles ventajas que podrían derivarse del cumplimiento con consumo aconsejado para estos alimentos. Métodos: búsqueda bibliográfica en relación con el tema. Resultados: los cereales de grano completo aportan cantidades elevadas de hidratos de carbono, fibra, vitaminas y minerales, cuya contribución a la dieta media ayuda a alcanzar las ingestas recomendadas y los objetivos nutricionales vigentes, por lo que su consumo en la cantidad aconsejada supone un beneficio nutricional. Por otra parte, diversos estudios señalan que un aumento en el consumo de cereales de grano completo se asocia con una protección frente al padecimiento de diversas enfermedades crónico-degenerativas (cardiovasculares, diabetes, síndrome metabólico y cáncer), ayudando en el mantenimiento de la salud digestiva y del peso corporal. Estos resultados pueden ser debidos al aporte de nutrientes, fibra y fitoquímicos, procedente de estos alimentos, así como al desplazamiento de la dieta de otros productos con un perfil nutricional menos conveniente, teniendo en cuenta la composición de la dieta media española. De hecho, el consumo de cereales de grano completo ha sido relacionado con una posible mejora en la microbiota intestinal y una mayor protección antioxidante. Pese a estas ventajas, el consumo de cereales es mirado con recelo por diversos individuos, especialmente por aquellas personas preocupadas por el control de peso, y los beneficios adicionales asociados al consumo de cereales de grano completo no son

  3. [Food allergy diagnosis in patients with elimination diet history. Preliminary report].

    PubMed

    Navarrete-Rodríguez, Elsy Maureen; Del Río-Navarro, Blanca Estela; Pozo-Beltrán, César Fireth; García-Fajardo, Daniela Edith; Saucedo-Ramírez, Omar Josué; Castelán-Chávez, Enrique Emanuel

    2014-01-01

    Antecedentes: el diagnóstico de alergia alimentaria se realiza idealmente con reto doble ciego controlado con placebo; sin embargo, en muchas ocasiones sólo se basa en la historia clínica, en las pruebas cutáneas o, incluso, en la percepción de los padres. Con gran frecuencia se prescriben dietas de eliminación sin el abordaje adecuado. Objetivos: analizar los resultados de las pruebas diagnósticas de alergia alimentaria en un grupo de niños con dieta de eliminación y verificar esos estudios con la prueba de reto doble ciego. Material y método: estudio observacional, analítico, prospectivo, efectuado en un grupo de pacientes con dieta de eliminación por sospecha de alergia alimentaria. Se realizaron pruebas por punción, Prick-to-Prick y de parche a todos los pacientes y posteriormente se verificó la positividad de esas pruebas mediante reto doble ciego controlado con placebo. Resultados: se incluyeron 43 pacientes con un total de 1,935 pruebas. En el abordaje para sensibilidad inmediata y tardía no se encontró ninguna relación estadísticamente significativa entre la positividad de la prueba y la eliminación del alimento. Al momento se han realizado 50 retos, de los que 4 fueron positivos (8%). Conclusiones: la frecuencia de alergia comprobada por reto doble ciego controlado con placebo en 50 retos fue de 8% (4/50), por lo que en este reporte preliminar encontramos una alta frecuencia de eliminación de alimentos sin el sustento adecuado. Es muy importante que el diagnóstico de alergia alimentaria sea acertado y se base en el abordaje adecuado, porque la implementación de una dieta de eliminación en una población muy vulnerable, como los pacientes pediátricos, es de suma importancia y puede influir de manera negativa en su crecimiento y desarrollo.

  4. ASSESSMENT OF THE FOOD PATTERNS OF IMMIGRANT ECUADORIAN POPULATION IN SOUTHERN SPAIN BASED ON A 24-H FOOD RECALL SURVEY.

    PubMed

    Neira-Mosquera, Juan Alejandro; Sanchez-Llaguno, Sungey; Pérez-Rodríguez, Fernando; Moreno-Rojas, Rafael

    2015-08-01

    Introducción: ecuador es un país con limitada información nutricional con la excepción de algunos estudios de carácter general realizados por FAO (Food Agriculture Organization). Objetivos: realizar una evaluación nutricional de la dieta de la población inmigrante ecuatoriana en el sur de España para determinar diferencias en los patrones alimentarios y posibles deficiencias nutricionales. Métodos: la evaluación nutricional se basa en un estudio de recordatorio de alimentos de 24 horas llevado acabo sobre la población ecuatoriana residente en Sevilla y Córdoba (España) en combinación con la aplicación de bases de datos nacionales e internacionales de composición de alimentos. Se estimaron los niveles de ingesta de nutrientes y el cumplimiento de las ingestas dietéticas de referencia (IDR) que se analizaron estadísticamente para los factores, genero, edad, profesión y ciudad. Resultados: según las IDR utilizadas, la distribución de macronutrientes y los niveles de ingesta de nutrientes fueron, en la mayoría de los casos, adecuadas. De manera destacada, se constató que los hábitos alimentarios ecuatorianos permanecieron en la población inmigrante, con el arroz como fuente principal de energía. Los niveles de ingesta fueron significativamente diferentes para diferentes nutrientes dependiendo del grupo de edad, sexo, lugar de residencia y ocupación profesional. Comparando estos datos con un estudio previo en Ecuador reveló que la población inmigrante en España presenta un mejor estado nutricional, si bien en ambas poblaciones se detectaron deficiencias en fibra, vitamina E, I y Se. En cuanto a estas deficiencias, los resultados no pueden considerarse concluyentes debido a limitaciones propias de las bases de datos (por ej. Se) y a la carencia de estudios adecuados que permitan una evaluación más precisa (por ej. estudios de larga duración para vitamina E). Conclusiones: estos resultados evidencian que la población inmigrante

  5. Dietary patterns of young adolescents in urban areas of northeast Brazil.

    PubMed

    de Morais, Célia Márcia Medeiros; Pinheiro, Liana Galvão Bacurau; Lima, Severina Carla Vieira Cunha; Lyra, Clelia Oliveira; de Sena Evangelista, Karine Cavalcanti Mauricio; Lima, Kenio Costa; Pedrosa, Lucia Fatima Campos

    2013-11-01

    Introducción: Estudios nacionales de evolución temporal encuentran que la tendencia del consumo alimentario se asocia con aumento de la prevalencia de las enfermedades crónicas. Objetivos: Caracterizar los hábitos alimentarios de los adolescentes en un área urbana del Noreste de Brasil, relacionándolos con los marcadores dietéticos saludables. Métodos: Estudio transversal con adolescentes (n=430) de las escuelas públicas de Natal-RN, Brasil. El consumo alimentario se evaluó mediante dos recordatorios 24h. La técnica de Análisis de Componentes Principales fue utilizada para derivar patrones dietéticos, de acuerdo con: alimentos en gramos (g), la energía en Kcal y la fibra en gramos, lo que resulta, respectivamente, en 3 componentes principales distintos: 7, 8 y 4 (varianza acumulada >70%; cargas factoriales >0,4). La asociación entre las variables independientes y los escores de los factores de todos los componentes obtenidos, se determinó por la razón de prevalencia (IC 95%). Resultados: Los patrones dietéticos fueron: el (1) Sistema Alimentario Tradicional puro representó el primero componente de los modelos; el (2) Sistema Alimentario Combinado y de riesgo reveló marcadores de alimentación no saludables, debido a la alta frecuencia de azucares refinados, grasas saturadas y sal; y el (3) Sistema Alimentario Modificado fue identificado en el modelo de las fibras, el patrón 1 de nuevo fue observado en este patrón. Las asociaciones observadas, en particular del patrón SATm, distinguen por sexo, edad y estado nutricional. Conclusiones: Los patrones dietéticos 1 y 3 se caracterizaron por la preservación de las prácticas regionales de alimentos, muy saludables, desde el punto de vista de la prevención de las enfermedades crónicas, mientras que el 2 representó alerta y riesgo para la salud. Los hallazgos pueden subvencionar Políticas de Atención a la Salud para infancia y adolescencia en carácter intersectorial.

  6. Predictors of adherence to the Mediterranean diet from the first to the second trimester of pregnancy.

    PubMed

    Abreu, Sandra; Santos, Paula Clara; Moreira, Pedro; Santos, Rute; Moreira, Carla; Montenegro, Nuno; Mota, Jorge

    2014-10-04

    Introducción: Aunque los cambios en los patrones pueden ocurrir durante la gestación, predictores de estos cambios no han sido exploradas. Este estudio pretende identificar predictores de la adhesión a la dieta mediterránea (DM) desde el primer al segundo trimestre del embarazo. Metodología: Se realizó un estudio prospectivo con 102 embarazadas de edad 18-40, de la ciudad de Oporto, Portugal. Se evaluaron las características socio-demográficas y de estilo de vida a través de un cuestionario. Consumo de alimentos se evaluó con un diario de alimentos de tres días concluido durante los primeras y segundo trimestres. Los participantes fueron categorizados según su cambio en la adhesión a la DM en el cambio negativo (es decir, las mujeres que tenían poca adhesión en cada trimestre o tenido alta adhesión en el primer trimestre y luego baja adhesión en el segundo) y el grupo de cambio positivo (es decir, las mujeres que tenían alta adhesión en ambos trimestres o tenía baja adhesión en el primer trimestre y luego elevada adhesión en el segundo). Modelos de regresión logística stepwise condicional se realizaron para evaluar los posibles predictores de la variación negativa de DM. Resultados: Entre las 102 mujeres, 39,2% tenían cambio negativo del primer al segundo trimestre. Los resultados model´s logística muestran que estar casada (OR = 0,26, IC95%: 0,10, 0,76) y tener una mayor ingesta de verduras en el primer trimestre (OR = 0,17, IC95%: 0,10, 0,43) se asociaron con menor probabilidad de tener un cambio negativo en la adhesión a la DM del primer al segundo trimestre. Conclusiones: Estado civil y el consumo de vegetal parecen estar asociado con una menor ocurrencia de cambio negativo en la adhesión a la MD desde temprano a medio embarazo.

  7. Efficacy of photographic educational materials for carbohydrate counting training of adolescents with diabetes mellitus.

    PubMed

    Servilha Gandolfo, Adriana; Vasconcelos Bastos, Débora; Jabur Makluf, Bruna Abreu; de Cassya Lopes Neri, Lenycia; Diaz Savoldelli, Roberta; Della Manna, Thais; Damiani, Durval; Archanjo Ferraro, Alexandre

    2014-02-01

    Antecedentes: El conteo de carbohidratos (CCH) es reconocido por la Asociación Americana de Diabetes (AAD) como una herramienta importante. Objetivo: Evaluar la eficacia de materiales educativos fotográficos en el entrenamiento de adolescentes con DM para realizar el CCH. Sujetos y Métodos: se distribuyó al azar a 76 adolescentes a dos grupos de orientación de CCH: mediante materiales fotográficos (Foto) o mediante listado de alimentos (Lista). Un mes después, se contactó a los participantes por teléfono para responder a preguntas sobre CCH para reforzar el entrenamiento (Encuesta). Dos días después de la encuesta, se pidió a los participantes que visitaran una cocina experimental para observar las porciones de los alimentos al natural y responder a un cuestionario sobre los pesos en gramos o equivalentes de carbohidratos de estas porciones. Se estableció la significación estadística en un valor de p < 0,05. Resultados: 54 adolescentes completaron el estudio (79,7 % mujeres), siendo el 51,8 % asignados al grupo Foto y el 48,1 % al grupo Lista. La edad promedio fue de 13,8 ± 2,0 años y el índice de masa corporal (IMC) promedio fue de 21,0 ± 3,2 kg/m2. Los participantes tenían un promedio de 7,9 ± 1,5 años de escolarización, y sus padres 8,0 ± 3,8 años. EL conocimiento en el CCH fue similar en ambos grupos antes de la intervención. Después de la misma, el grupo Foto consiguió una diferencia significativa en la tasa de aciertos en el test de evaluación del CCH con respecto al grupo Lista (Foto: 2,5 frente a Lista: 1.0; p = 0,03). Conclusiones: el material educativo fotográfico fue más eficaz a la hora de ayudar a los adolescentes con DM a comprender y aprender a realizar el conteo de hidratos de carbono.

  8. Changing dietary habits among Akwen Xerente.

    PubMed

    Rocha, Tatiana Evangelista da Silva; Silva, Reijane Pinheiro da; Nascimento, Maira Messias do

    2016-06-01

    The research aimed to identify the current feed of Xerente people in Indian villages Porteira and Funil in the city of Tocantinia / TO. It was used a qualitative ethnographic approach. Conducted from September 2013 to August 2014. The data were presented in a diary, through participant observation of food practices with the guidance of a script. A process of dietary change that permeates the culture of this people is taking place. Factors such as the deficit in the planting gardens, the recent arrival of energy, and therefore the technology has allowed access to processed foods. But some families still maintain the farming of cassava, yam, and beans. The main animals that are hunted in the village are peccary, deer and armadillo. It was possible to point which foods are inserted in the Xerente feed and factors related to this situation. A pesquisa objetivou identificar a alimentação atual do povo Xerente, nas aldeias indígenas Porteira e Funil, no município de Tocantínia / TO. Utilizou-se uma abordagem etnográfica qualitativa. Realizada entre setembro de 2013 a agosto de 2014. Os dados foram descritos através de um diário de campo, por meio da observação das práticas alimentares com a orientação de um roteiro. Está ocorrendo um processo de mudança alimentar na cultura deste povo. Fatores como o déficit no plantio das roças, a chegada da energia, e consequentemente a tecnologia, permitiu o acesso a alimentos industrializados. Mas algumas famílias ainda mantem o cultivo de mandioca, inhame, feijão andu. Os principais animais que são caçados na aldeia são caititu, veado e tatu. Foi possível encontrar a presença de alimentos industrializados inseridos na alimentação do Xerente e isso tem provocado alterações nos hábitos desse povo. PMID:27384282

  9. SCHOOL DIETARY HABITS AND INCIDENCE OF DENTAL CARIES.

    PubMed

    Monteagudo, Celia; Téllez, Francisco; Heras-González, Leticia; Ibañez-Peinado, Diana; Mariscal-Arcas, Miguel; Olea-Serrano, Fatima

    2015-07-01

    Introducción: los hábitos alimentarios saludables influyen sobre la salud oral. El tratamiento de la caries comprende la restauración dental con selladores y composites dentales, la mayoría con bisfenol A (BPA). Hipótesis: a) el desayuno y hábitos de higiene oral son factores importantes en el desarrollo de caries; b) el tratamiento de la caries con epoxirresinas conlleva riesgo de exposición oral a monómeros plásticos. Objetivo: relacionar la ingesta del desayuno y los hábitos de higiene oral con la caries dental y determinar la presencia de selladores/composites como fuentes potenciales de exposición al BPA. Métodos: se analizaron 582 niños/as en edad escolar de Granada (sur de España) de 7 años de edad (7,55 [0,64] años). Se empleó un cuestionario de frecuencia de consumo de alimentos, 3 recordatorios de 24 h y variables de estilo de vida, incluyendo la higiene bucodental. La calidad del desayuno fue estimada con el Breakfast Quality Index (BQI). Resultados: se detectó un 21,7% de caries. El valor medio del BQI fue 5,18 (1,29). El 24% de la población realizó un desayuno con alimentos ricos en azúcares simples (> 5% de la energía total), asociado significativamente con la frecuencia de caries en el análisis de regresión logística. El 35,8% de los participantes tomaron galletas; asociado significativamente con la frecuencia de caries. La ingesta de productos de panadería, cereales y lácteos mostró una asociación inversamente significativa con la frecuencia de caries. Conclusión: se necesitan más investigaciones para aclarar el papel de la dieta en la caries y el riesgo de exposición a xenobióticos estrogénicos, como el BPA.

  10. [ADHERENCE TO THE MEDITERRANEAN DIET AND HYDRATION IN SPANISH AND MOROCCAN POPULATIONS].

    PubMed

    Benhammou, Samira; Monteagudo, Celia; Mariscal-Arcas, Miguel; Ortega, Virginia; Rivas, Ana; Ortega, Eduardo; Lorenzo, M Luisa; Olea-Serrano, Fatima

    2015-12-01

    Introducción: la dieta mediterránea (DM) comprende la ribera europea, africana y asiática del mar Mediterráneo. Características de la DM son variedad de alimentos y sobriedad. Junto a los nutrientes, es esencial la ingesta de agua y bebidas. Objetivo: estudiar la DM y la contribución del agua y las bebidas a la hidratación de dos poblaciones de la ribera mediterránea. Métodos: adultos procedentes del noroeste de Marruecos y sur de España (n = 400), completaron un cuestionario semi-cuantitativo de frecuencia de consumo de alimentos. Se analizó agua envasada consumida por la población y comprada en el mercado local (17 marcas/ tipos en Marruecos y 30 en el sur de España). Resultados: por cromatografía de intercambio iónico se analizaron diversas sales. El rango fue: Ca entre 140,16 y 439 mg/L; Mg entre 53,15 y 87,5 mg/L; Na entre 1169,78 y 257,2 mg/L y K 50,26 y 26,5 mg/L, valores tanto para muestras españolas como marroquís. Son aguas de mineralización media y su ingesta de minerales no contribuye más del 7% a la RDA de las poblaciones estudiadas. El seguimiento de la DM es superior en la población española (6,28 ± 1,38) que en la marroquí (4,42 ± 1,52). El perfil de ingesta de bebidas permite clasificar a la población al encontrar valores OR que van desde 1,6 a 11,01 para mayor ingesta de zumo, refrescos, te, agua envasada y total de ingesta de líquidos para la población marroquí frente a la española. Conclusión: el consumo de aguas envasadas no supone un suplemento mineral de interés en estas poblaciones.

  11. [Not Available].

    PubMed

    Perales-García, Aránzazu; Estévez-Martínez, Isabel; Urrialde, Rafael

    2016-01-01

    Introducción: la hidratación se define como el aporte de agua proveniente de alimentos y bebidas. Su estudio constituye desde hace unos años un área en sí misma dentro de la nutrición, que ha supuesto que en 2010 la European Food Safety Authority (EFSA) aprobara las recomendaciones de ingesta de agua; pero el estudio del estado de hidratación implica un elevado nivel metodológico que presenta ciertos desafíos. Objetivo: ofrecer una visión general de los principales problemas metodológicos en estudios sobre el estado de hidratación. Material y métodos: revisión de la bibliografía científica existente. Resultados: los principales problemas metodológicos presentes son: selección de la muestra (ámbito de investigación y diseño muestral), selección del método de evaluación del estado de hidratación (técnicas de dilución, impedancia bioeléctrica, indicadores plasmáticos y urinarios, cambios en la composición corporal, pérdidas de agua y síntomas clínicos), selección del método de valoración de la ingesta de agua (biomarcadores, cuestionarios, programas informáticos, uso de smartphones, registro 24 h, historia dietética y frecuencia de consumo de alimentos), así como sus principales fuentes dietéticas. Conclusiones: el estado de hidratación debe ser entendido como un modelo rutinario, de frecuencia diaria y variable en función de la edad, sexo, actividad física y condiciones ambientales; por todo ello es de especial importancia un correcto diseño metodológico capaz de recoger estos matices. PMID:27571857

  12. Key drivers controlling stable isotope variations in daily precipitation of Costa Rica: Caribbean Sea versus Eastern Pacific Ocean moisture sources

    NASA Astrophysics Data System (ADS)

    Sánchez-Murillo, R.; Birkel, C.; Welsh, K.; Esquivel-Hernández, G.; Corrales-Salazar, J.; Boll, J.; Brooks, E.; Roupsard, O.; Sáenz-Rosales, O.; Katchan, I.; Arce-Mesén, R.; Soulsby, C.; Araguás-Araguás, L. J.

    2016-01-01

    Costa Rica is located on the Central American Isthmus, which receives moisture inputs directly from the Caribbean Sea and the Eastern Pacific Ocean. This location includes unique mountainous and lowland microclimates, but only limited knowledge exists about the impact of relief and regional atmospheric circulation patterns on precipitation origin, transport, and isotopic composition. Therefore, the main scope of this project is to identify the key drivers controlling stable isotope variations in daily-scale precipitation of Costa Rica. The monitoring sites comprise three strategic locations across Costa Rica: Heredia (Central Valley), Turrialba (Caribbean slope), and Caño Seco (South Pacific slope). Sporadic dry season rain is mostly related to isolated enriched events ranging from -5.8‰ to -0.9‰ δ18O. By mid-May, the Intertropical Convergence Zone reaches Costa Rica resulting in a notable depletion in isotope ratios (up to -18.5‰ δ18O). HYSPLIT air mass back trajectories indicate the strong influence on the origin and transport of precipitation of three main moisture transport mechanisms, the Caribbean Low Level Jet, the Colombian Low Level Jet, and localized convection events. Multiple linear regression models constructed based on Random Forests of surface meteorological information and atmospheric sounding profiles suggest that lifted condensation level and surface relative humidity are the main factors controlling isotopic variations. These findings diverge from the recognized 'amount effect' in monthly composite samples across the tropics. Understanding of stable isotope dynamics in tropical precipitation can be used to a) enhance groundwater modeling efforts in ungauged basins where scarcity of long-term monitoring data drastically limit current and future water resources management, b) improve the re-construction of paleoclimatic records in the Central American land bridge, c) calibrate and validate regional circulation models.

  13. Impact of vitamin D receptor polymorphisms in centenarians.

    PubMed

    Gussago, Cristina; Arosio, Beatrice; Guerini, Franca Rosa; Ferri, Evelyn; Costa, Andrea Saul; Casati, Martina; Bollini, Elisa Mariadele; Ronchetti, Francesco; Colombo, Elena; Bernardelli, Giuseppina; Clerici, Mario; Mari, Daniela

    2016-08-01

    Vitamin D is a seco-sterol produced endogenously in the skin or obtained from certain foods. It exerts its action through binding to intracellular vitamin D receptor (VDR). Lately, the role of vitamin D has been revised regarding its potential advantage on delaying the process of aging. The aim of this study was to assess the contribution of VDR gene polymorphisms in healthy aging and longevity. We evaluated the frequency of four polymorphisms of the VDR gene (FokI, BsmI, ApaI, and TaqI) in centenarians (102 subjects, mean age: 102.3 ± 0.3 years), compared to septuagenarians (163 subjects, mean age: 73.0 ± 0.6 years) and we analyzed a variety of pathophysiologically relevant functions in centenarians. BsmI and ApaI provided a significant association with longevity: there was a highly significant difference in the frequency of BsmI genotypes (p = 0.037), ApaI genotypes (p = 0.022), and ApaI alleles (p = 0.050) in centenarians versus septuagenarians. Furthermore, we found a significant correlation of all the VDR gene polymorphisms in centenarians with some measured variables such as hand grip strength, body mass index, blood pressure, HDL cholesterol, and mini-mental state examination. We also found a correlation with the prevalence of medical history of hypertension, acute myocardial infarction, angina, venous insufficiency, dementia, chronic obstructive pulmonary disease, and arthrosis. In conclusion, this study proposes a new scenario in which the variability of the VDR gene is relevant in the aging process and emphasizes the role of VDR genetic background in determining healthy aging. PMID:26956844

  14. Carbon transformation and the sources of dissolved inorganic carbonate in sediments of a temperate coastal sea, the Baltic Sea: A stable isotope and modelling approach

    NASA Astrophysics Data System (ADS)

    Lipka, Marko; Liu, Bo; Wegwerth, Antje; Dellwig, Olaf; Winde, Vera; Al-Raei, Abdul M.; Böttcher, Michael E.

    2015-04-01

    Organic matter is mineralized in brackish-marine sediments by microbial activity using predominantly and sulfate as electron acceptors. Under anoxic bottom water conditions, sulfate reduction dominates. Pore water profiles reflect net biogeochemical processes, transformation rates and fluxes of dissolved species across the sediment-water interface. Element fluxes across the sediment-water interface are controlled by different boundary conditions. We present the results of a detailed biogeochemical investigation of interstitial waters from different sediments of the Baltic Sea covering the range of sedimentological and bottom water redox conditions. It was the aim to study the biogeochemical transformation processes and associated element fluxes at the sediment-water-interface and the role of organic matter or methane as potential substrates for microbial activity. Short sediment cores were collected during several research cruises with multicoring devices. Pore waters were analyzed for nutrients, major and trace element concentrations to allow a modelling of net volumetric transformation rates and diffusive element fluxes. Gross sulfate reduction rates were measured in selected cores using incubations with radiotracer. As a tracer for the source of dissolved inorganic carbonate (DIC) the carbon isotope composition was measured. A quantitative interpretation of vertical concentration profiles in the pore waters was performed using different modelling approaches. Element fluxes across the sediment-water interface show a dependence from bottom water redox conditions, sediment compositions, and sedimentation conditions. It is shown that the carbon isotope composition of DIC is a valuable and sensitive parameter in a model-based estimate of the impact of biological and physical mixing of surface sediments. Research is supported by German BMBF within the KÜNO-SECOS project and Leibniz IOW

  15. A review on phytochemical, pharmacological, and pharmacognostical profile of Wrightia tinctoria: Adulterant of kurchi

    PubMed Central

    Srivastava, Rajani

    2014-01-01

    Wrightia tinctoria R. Br. belongs to family Apocynaceae commonly called as Sweet Indrajao, Pala Indigo Plant, Dyer's Oleander. “Jaundice curative tree” in south India. Sweet Indrajao is a small, deciduous tree with a light gray, scaly smooth bark. Native to India and Burma, Wrightia is named after a Scottish physician and botanist William Wright (1740-1827). Sweet Indrajao is called dhudi (Hindi) because of its preservative nature. The juice of the tender leaves is used efficaciously in jaundice. Crushed fresh leaves when filled in the cavity of decayed tooth relieve toothache. In Siddha system of medicine, it is used for psoriasis and other skin diseases. Oil 777 prepared out of the fresh leaves of the plant has been assigned to analgesic, anti-inflammatory, and anti-pyretic activities and to be effective in the treatment of psoriasis. The plant is reported to contain presence of flavanoid, glycoflavones-iso-orientin, and phenolic acids. The various chemical constituents isolated from various parts of the plant are reported as 3,4-Seco-lup-20 (29)-en-3-oic acid, lupeol, stigmasterol and campetosterol, Indigotin, indirubin, tryptanthrin, isatin, anthranillate and rutin Triacontanol, Wrightial, cycloartenone, cycloeucalenol, β-amyrin, Alpha-Amyrin, and β-sitosterol, 14α-methylzymosterol. Four uncommon sterols, desmosterol, clerosterol, 24-methylene-25-methylcholesterol, and 24-dehydropollinastanol, were isolated and identified in addition to several more common phytosterols. The Triterpinoids components of the leaves and pods of Wrightia tinctoria also isolated. This article intends to provide an overview of the chemical constituents present in various parts of the plants and their pharmacological actions and pharmacognostical evaluation. PMID:24600194

  16. Seasonal and Interannual Variations of Stream Chemistry in an Urban Fringe Watershed in Southern California

    NASA Astrophysics Data System (ADS)

    Hogue, T. S.; Barco, J.; Rademacher, L.

    2007-12-01

    Understanding the hydrological, geochemical and biological watershed processes involved in ecosystem evolution involves numerous scientific challenges. The transition from undisturbed to urbanized landscapes has impacted ecosystems worldwide. Of critical concern is ecosystem degradation in undisturbed watersheds due to regional atmospheric deposition. This study focuses on the undeveloped, upper reaches of the Arroyo Seco watershed, located on the eastern edge of the Los Angeles basin, where estimates of dry deposition are considered some of the highest in North America. Weekly water quality grab samples were collected from April 2004 to December 2006 and analyzed for standard geochemical constituents. Atmospheric wet deposition for different constituents was obtained from the National Atmospheric Deposition Program (NADP) site located in eastern Los Angeles County. Hydrologic, geochemical and atmospheric data were assessed at various time scales to evaluate current hydro-geochemical dynamics and ecosystem response to the impacts of large-scale regional urbanization. For almost all the constituents, streamwater concentrations are higher in the fall and lower in the spring, while atmospheric wet deposition values are higher in the summer and lower in the winter. The streamwater chemistry also exhibits interannual variation which can be primarily explained by the interactions of the hydrological and biogeochemical cycles. Seasonal stream concentration-discharge relationships were developed using a hyperbolic dilution model. In general, the developed model results in a better fit for the cations rather than anions. Model results were used to predict seasonal and annual mass loadings to downstream urban streams. Both observations and model predictions indicate the watershed is a sink for atmospheric nitrate and a source for various cations.

  17. Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.

    PubMed

    Kidd, Parris M

    2010-09-01

    Vitamins D and K are lipid-phase nutrients that are pleiotropic - endowed with versatile homeostatic capacities at the organ, tissue, and cellular levels. Their metabolic and physiologic roles overlap considerably, as evidenced in the bone and cardiovascular systems. Vitamin D₃ (cholecalciferol, D₃) is the prehormone for the vitamin D endocrine system. Vitamin D₃ undergoes initial enzymatic conversion to 25-hydroxyvitamin D (25D, calcidiol), then to the seco-steroid hormone 1alpha, 25-dihydroxyvitamin D (1,25D, calcitriol). Beyond its endocrine roles in calcium homeostasis, 1,25D likely has autocrine, paracrine, and intracrine effects. At least 17 tissues likely synthesize 1,25D, and 35 carry the vitamin D receptor (VDR). Vitamin D functional deficiency is widespread in human populations. Vitamin K₁ (phylloquinone) is more abundant in foods but less bioactive than the vitamin K₂ menaquinones (especially MK-4, menatetrenone). Menadione (vitamin K₃) has minimal K activity. Vitamin K compounds undergo oxidation-reduction cycling within the endoplasmic reticulum membrane, donating electrons to activate specific proteins via enzymatic gamma-carboxylation of glutamate groups before being enzymatically re-reduced. Warfarin inhibits this vitamin K reduction, necessitating K supplementation during anticoagulation therapy. Along with coagulation factors (II, VII, IX, X, and prothrombin), protein C and protein S, osteocalcin (OC), matrix Gla protein (MGP), periostin, Gas6, and other vitamin K-dependent (VKD) proteins support calcium homeostasis, facilitate bone mineralization, inhibit vessel wall calcification, support endothelial integrity, are involved in cell growth control and tissue renewal, and have numerous other effects. This review updates vitamin D and K skeletal and cardiovascular benefits and evidence for their synergy of action. PMID:21155624

  18. Impact of vitamin D receptor polymorphisms in centenarians.

    PubMed

    Gussago, Cristina; Arosio, Beatrice; Guerini, Franca Rosa; Ferri, Evelyn; Costa, Andrea Saul; Casati, Martina; Bollini, Elisa Mariadele; Ronchetti, Francesco; Colombo, Elena; Bernardelli, Giuseppina; Clerici, Mario; Mari, Daniela

    2016-08-01

    Vitamin D is a seco-sterol produced endogenously in the skin or obtained from certain foods. It exerts its action through binding to intracellular vitamin D receptor (VDR). Lately, the role of vitamin D has been revised regarding its potential advantage on delaying the process of aging. The aim of this study was to assess the contribution of VDR gene polymorphisms in healthy aging and longevity. We evaluated the frequency of four polymorphisms of the VDR gene (FokI, BsmI, ApaI, and TaqI) in centenarians (102 subjects, mean age: 102.3 ± 0.3 years), compared to septuagenarians (163 subjects, mean age: 73.0 ± 0.6 years) and we analyzed a variety of pathophysiologically relevant functions in centenarians. BsmI and ApaI provided a significant association with longevity: there was a highly significant difference in the frequency of BsmI genotypes (p = 0.037), ApaI genotypes (p = 0.022), and ApaI alleles (p = 0.050) in centenarians versus septuagenarians. Furthermore, we found a significant correlation of all the VDR gene polymorphisms in centenarians with some measured variables such as hand grip strength, body mass index, blood pressure, HDL cholesterol, and mini-mental state examination. We also found a correlation with the prevalence of medical history of hypertension, acute myocardial infarction, angina, venous insufficiency, dementia, chronic obstructive pulmonary disease, and arthrosis. In conclusion, this study proposes a new scenario in which the variability of the VDR gene is relevant in the aging process and emphasizes the role of VDR genetic background in determining healthy aging.

  19. Pre- and post-fire pollutant loads in an urban fringe watershed in Southern California.

    PubMed

    Burke, M P; Hogue, T S; Kinoshita, A M; Barco, J; Wessel, C; Stein, E D

    2013-12-01

    Post-fire runoff has the potential to be a large source of contaminants to downstream areas. However, the magnitude of this effect in urban fringe watersheds adjacent to large sources of airborne contaminants is not well documented. The current study investigates the impacts of wildfire on stormwater contaminant loading from the upper Arroyo Seco watershed, burned in 2009. This watershed is adjacent to the Greater Los Angeles, CA, USA area and has not burned in over 60 years. Consequently, it acts as a sink for regional urban pollutants and presents an opportunity to study the impacts of wildfire. Pre- and post-fire storm samples were collected and analyzed for basic cations, trace metals, and total suspended solids. The loss of vegetation and changes in soil properties from the fire greatly increased the magnitude of storm runoff, resulting in sediment-laden floods carrying high concentrations of particulate-bound constituents. Post-fire concentrations and loads were up to three orders of magnitude greater than pre-fire values for many trace metals, including lead and cadmium. A shift was also observed in the timing of chemical delivery, where maximum suspended sediment, trace metal, and cation concentrations coincided with, rather than preceded, peak discharge in the post-fire runoff, amplifying the fire's impacts on mass loading. The results emphasize the importance of sediment delivery as a primary mechanism for post-fire contaminant transport and suggest that traditional management practices that focus on treating only the early portion of storm runoff may be less effective following wildfire. We also advocate that watersheds impacted by regional urban pollutants have the potential to pose significant risk for downstream communities and ecosystems after fire.

  20. Two Transporters Essential for Reassimilation of Novel Cholate Metabolites by Rhodococcus jostii RHA1

    PubMed Central

    Swain, Kendra; Casabon, Israël; Eltis, Lindsay D.

    2012-01-01

    The bacterial uptake of steroids and their metabolites remains poorly understood. We investigated two transporters associated with cholate catabolism in Rhodococcus jostii RHA1. Reverse transcriptase quantitative-PCR indicated that an ATP-binding cassette (ABC) transporter and a major facilitator superfamily (MFS) transporter were upregulated 16.7- and 174-fold, respectively, during the exponential phase of growth on cholate compared to growth on pyruvate. Gene knockout analysis established that these transporters are required for the reassimilation of distinct metabolites that accumulate during growth on cholate. The ABC transporter, encoded by camABCD, was essential for uptake of 1β(2′-propanoate)-3aα-H-4α(3″(R)-hydroxy-3″-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog. The MFS transporter, encoded by camM, was essential for uptake of 3,7(R),12(S)-trihydroxy-9-oxo-9,10-seco-23,24-bisnorchola-1,3,5(10)-trien-22-oate. These metabolites differ from cholate metabolites reported to be excreted by proteobacteria in that they retain an isopropanoyl side chain at C-17. The uptake of these metabolites was necessary for maximal growth on cholate: a ΔcamB mutant lacking the permease component of the ABC transporter and a ΔcamM mutant lacking the MFS transporter grew to 74% and 77%, respectively, of the yield of the wild type. This study demonstrates for the first time the requirement for specific transporters for uptake of cholate metabolites and highlights the importance and complexity of transport processes associated with bacterial steroid catabolism. PMID:23024344

  1. Vitamin D3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects.

    PubMed

    Campbell, M J; Reddy, G S; Koeffler, H P

    1997-09-01

    The seco-steroid hormone, 1 alpha, 25 dihydroxyvitamin D3 (1 alpha,25(OH)2D3) binds to a specific nuclear receptor that acts as a ligand-inducible transcription factor. The resulting genomic effects include partial arrest in G0/G1 of the cell cycle and induction of differentiation; these effects have been observed in various types of cancer. Recently, we produced enzymatically the natural 24-oxo metabolites of 1 alpha,25(OH)2D3 and two of its potent synthetic analogs (1 alpha,25-(OH)2-16-ene-D3 and 1 alpha,25-(OH)2-20-epi-D3) using a rat kidney perfusion system. We have found that the 24-oxo metabolites of both 1 alpha,25(OH)2D3 and its analogs have either the same or greater antiproliferative activity against various cancer cells as their parental compounds. Notably, two cell lines (DU-145 (prostate cancer) and MDA-MB-436 [breast cancer]) that were extremely resistant to the antiproliferative effects of vitamin D3 analogs displayed greater sensitivity towards the 24-oxo metabolite of the vitamin D3 analog. Similarly, the 24-oxo metabolites had the capacity to induce differentiation and apoptosis and to diminish the proportion of cells in S phase. Most interestingly, while the analog 1 alpha,25(OH)2-20-epi-D3 induced expression of BRCA1 in MCF-7 breast cancer cells; its 24-oxo metabolite dramatically suppressed BRAC1 expression. Thus, we have shown for the first time that the various biological activities produced by the hormone 1 alpha,25(OH)2D3 and some of its analogs may represent a combination of actions by the hormone 1 alpha,25(OH)2D3 and its natural 24-oxo metabolites.

  2. Texas LPG fuel cell development and demonstration project

    SciTech Connect

    None, None

    2004-07-26

    The State Energy Conservation Office has executed its first Fuel Cell Project which was awarded under a Department of Energy competitive grant process. The Texas LPG Fuel Processor Development and Fuel Cell Demonstration Program is a broad-based public/private partnership led by the Texas State Energy Conservation Office (SECO). Partners include the Alternative Fuels Research and Education Division (AFRED) of the Railroad Commission of Texas; Plug Power, Inc., Latham, NY, UOP/HyRadix, Des Plaines, IL; Southwest Research Institute (SwRI), San Antonio, TX; the Texas Natural Resource Conservation Commission (TNRCC), and the Texas Department of Transportation (TxDOT). The team proposes to mount a development and demonstration program to field-test and evaluate markets for HyRadix's LPG fuel processor system integrated into Plug Power's residential-scale GenSys(TM) 5C (5 kW) PEM fuel cell system in a variety of building types and conditions of service. The program's primary goal is to develop, test, and install a prototype propane-fueled residential fuel cell power system supplied by Plug Power and HyRadix in Texas. The propane industry is currently funding development of an optimized propane fuel processor by project partner UOP/HyRadix through its national checkoff program, the Propane Education and Research Council (PERC). Following integration and independent verification of performance by Southwest Research Institute, Plug Power and HyRadix will produce a production-ready prototype unit for use in a field demonstration. The demonstration unit produced during this task will be delivered and installed at the Texas Department of Transportation's TransGuide headquarters in San Antonio, Texas. Simultaneously, the team will undertake a market study aimed at identifying and quantifying early-entry customers, technical and regulatory requirements, and other challenges and opportunities that need to be addressed in planning commercialization of the units. For further

  3. Preliminary Evaluation of Removing Used Nuclear Fuel From Nine Shutdown Sites

    SciTech Connect

    Maheras, Steven J.; Best, Ralph; Ross, Steven B.; Buxton, Kenneth A.; England, Jeffery L.; McConnell, Paul

    2013-04-30

    The Blue Ribbon Commission on America’s Nuclear Future identified removal of stranded used nuclear fuel at shutdown sites as a priority so that these sites may be completely decommissioned and put to other beneficial uses. In this report, a preliminary evaluation of removing used nuclear fuel from nine shutdown sites was conducted. The shutdown sites included Maine Yankee, Yankee Rowe, Connecticut Yankee, Humboldt Bay, Big Rock Point, Rancho Seco, Trojan, La Crosse, and Zion. At these sites a total of 7649 used nuclear fuel assemblies and a total of 2813.2 metric tons heavy metal (MTHM) of used nuclear fuel are contained in 248 storage canisters. In addition, 11 canisters containing greater-than-Class C (GTCC) low-level radioactive waste are stored at these sites. The evaluation was divided in four components: • characterization of the used nuclear fuel and GTCC low-level radioactive waste inventory at the shutdown sites • an evaluation of the onsite transportation conditions at the shutdown sites • an evaluation of the near-site transportation infrastructure and experience relevant to the shipping of transportation casks containing used nuclear fuel from the shutdown sites • an evaluation of the actions necessary to prepare for and remove used nuclear fuel and GTCC low-level radioactive waste from the shutdown sites. Using these evaluations the authors developed time sequences of activities and time durations for removing the used nuclear fuel and GTCC low-level radioactive waste from a single shutdown site, from three shutdown sites located close to each other, and from all nine shutdown sites.

  4. Accumulation, transformation and breakdown of DSP toxins from the toxic dinoflagellate Dinophysis acuta in blue mussels, Mytilus edulis.

    PubMed

    Nielsen, Lasse Tor; Hansen, Per Juel; Krock, Bernd; Vismann, Bent

    2016-07-01

    Okadaic acid (OA), dinophysistoxins (DTX) and pectenotoxins (PTX) produced by the dinoflagellates Dinophysis spp. can accumulate in shellfish and cause diarrhetic shellfish poisoning upon human consumption. Shellfish toxicity is a result of algal abundance and toxicity as well as accumulation and depuration kinetics in mussels. We mass-cultured Dinophysis acuta containing OA, DTX-1b and PTX-2 and fed it to the blue mussel, Mytilus edulis under controlled laboratory conditions for a week to study toxin accumulation and transformation. Contents of OA and DTX-1b in mussels increased linearly with incubation time, and the net toxin accumulation was 66% and 71% for OA and DTX-1b, respectively. Large proportions (≈50%) of both these toxins were transformed to fatty acid esters. Most PTX-2 was transformed to PTX-2 seco-acid and net accumulation was initially high, but decreased progressively throughout the experiment, likely due to esterification and loss of detectability. We also quantified depuration during the subsequent four days and found half-life times of 5-6 days for OA and DTX-1b. Measurements of dissolved toxins revealed that depuration was achieved through excreting rather than metabolizing toxins. This is the first study to construct a full mass balance of DSP toxins during both accumulation and depuration, and we demonstrate rapid toxin accumulation in mussels at realistic in situ levels of Dinophysis. Applying the observed accumulation and depuration kinetics, we model mussel toxicity, and demonstrate that a concentration of only 75 Dinophysis cells l(-1) is enough to make 60 mm long mussels exceed the regulatory threshold for OA equivalents.

  5. [Not Available].

    PubMed

    Hernando-Requejo, Virgilio

    2016-07-12

    La demencia, estrechamente ligada a factores predisponentes ambientales como la dieta, supone un problema de salud pública de magnitud creciente: actualmente más de 35 millones de pacientes con demencia tipo alzhéimer, y se espera que superen los 135 millones en 2050. Si conseguimos retrasar el desarrollo de la demencia 5 años, reduciremos su prevalencia en un 50%. Los pacientes con demencia alteran su dieta y se han reportado déficits, entre otros, de ácido fólico, vitaminas B12, B6, C, E, A, D, K, betacarotenos y omega tres, que deben ser resueltos con una dieta adecuada y, en según qué casos, con aportes extra. Pero para reducir o al menos retrasar la prevalencia debemos preconizar la prevención mediante una dieta adecuada desde el inicio de la vida, idea reforzada por el hecho de que los factores de riesgo cardiovascular se relacionen de forma directa con el desarrollo de demencia. Disponemos de abundante bibliografía que, aunque con límites, nos permite hacer recomendaciones nutricionales para prevenir el deterioro cognitivo. Se han conseguido mejores resultados cuando se han estudiado dietas completas que cuando se han considerado nutrientes específicos. De especial interés es la dieta mediterránea, que garantiza un aporte elevado de vegetales, frutas, frutos secos, legumbres, cereales, pescado y aceite de oliva, y moderado de carne, productos lácteos y alcohol, y en la que nos centraremos en este artículo.

  6. [Not Available].

    PubMed

    Hernando-Requejo, Virgilio

    2016-01-01

    La demencia, estrechamente ligada a factores predisponentes ambientales como la dieta, supone un problema de salud pública de magnitud creciente: actualmente más de 35 millones de pacientes con demencia tipo alzhéimer, y se espera que superen los 135 millones en 2050. Si conseguimos retrasar el desarrollo de la demencia 5 años, reduciremos su prevalencia en un 50%. Los pacientes con demencia alteran su dieta y se han reportado déficits, entre otros, de ácido fólico, vitaminas B12, B6, C, E, A, D, K, betacarotenos y omega tres, que deben ser resueltos con una dieta adecuada y, en según qué casos, con aportes extra. Pero para reducir o al menos retrasar la prevalencia debemos preconizar la prevención mediante una dieta adecuada desde el inicio de la vida, idea reforzada por el hecho de que los factores de riesgo cardiovascular se relacionen de forma directa con el desarrollo de demencia. Disponemos de abundante bibliografía que, aunque con límites, nos permite hacer recomendaciones nutricionales para prevenir el deterioro cognitivo. Se han conseguido mejores resultados cuando se han estudiado dietas completas que cuando se han considerado nutrientes específicos. De especial interés es la dieta mediterránea, que garantiza un aporte elevado de vegetales, frutas, frutos secos, legumbres, cereales, pescado y aceite de oliva, y moderado de carne, productos lácteos y alcohol, y en la que nos centraremos en este artículo. PMID:27571865

  7. Ruminal Prevotella spp. May Play an Important Role in the Conversion of Plant Lignans into Human Health Beneficial Antioxidants

    PubMed Central

    Schogor, Ana L. B.; Huws, Sharon A.; Santos, Geraldo T. D.; Scollan, Nigel D.; Hauck, Barbara D.; Winters, Ana L.; Kim, Eun J.; Petit, Hélène V.

    2014-01-01

    Secoisolariciresinol diglucoside (SDG), the most abundant lignan in flaxseed, is metabolized by the ruminal microbiota into enterolignans, which are strong antioxidants. Enterolactone (EL), the main mammalian enterolignan produced in the rumen, is transferred into physiological fluids, with potentially human health benefits with respect to menopausal symptoms, hormone-dependent cancers, cardiovascular diseases, osteoporosis and diabetes. However, no information exists to our knowledge on bacterial taxa that play a role in converting plant lignans into EL in ruminants. In order to investigate this, eight rumen cannulated cows were used in a double 4×4 Latin square design and fed with four treatments: control with no flax meal (FM), or 5%, 10% and 15% FM (on a dry matter basis). Concentration of EL in the rumen increased linearly with increasing FM inclusion. Total rumen bacterial 16S rRNA concentration obtained using Q-PCR did not differ among treatments. PCR-T-RFLP based dendrograms revealed no global clustering based on diet indicating between animal variation. PCR-DGGE showed a clustering by diet effect within four cows that had similar basal ruminal microbiota. DNA extracted from bands present following feeding 15% FM and absent with no FM supplementation were sequenced and it showed that many genera, in particular Prevotella spp., contributed to the metabolism of lignans. A subsequent in vitro study using selected pure cultures of ruminal bacteria incubated with SDG indicated that 11 ruminal bacteria were able to convert SDG into secoisolariciresinol (SECO), with Prevotella spp. being the main converters. These data suggest that Prevotella spp. is one genus playing an important role in the conversion of plant lignans to human health beneficial antioxidants in the rumen. PMID:24709940

  8. Understanding key drivers controlling daily stable isotope variations in precipitation of Costa Rica, Central America

    NASA Astrophysics Data System (ADS)

    Sanchez-Murillo, Ricardo; Welsh, Kristin; Birkel, Christian; Esquivel-Hernández, Germain; Corrales-Salazar, Jose; Boll, Jan; Brooks, Erin; Roupsard, Olivier; Katchan, Irina; Arce-Mesén, Rafael; Soulsby, Chris; Araguás-Araguás, Luis

    2015-04-01

    Costa Rica is located on the Central American Isthmus, which receives direct moisture inputs from the Caribbean Sea and the Pacific Ocean. The relatively narrow, but high relief Central American land bridge is characterized by unique mountainous and lowland microclimates. However, only limited knowledge exists about the impact of relief and regional atmospheric circulation patterns on precipitation origin, transport, and isotopic composition in this tropical region. Therefore, the main scope of this study is to identify the key drivers controlling variations in meteoric waters of Costa Rica using stable isotopes based on daily sample collection for the year 2013. The monitoring sites comprise three strategic locations across Costa Rica: Heredia (Central Valley), Turrialba (Caribbean slope), and Caño Seco (South Pacific slope). Sporadic dry season rain is mostly related to isolated enriched events ranging from -5.8‰ d18O up to -0.9‰ d18O. By mid-May, the Intertropical Convergence Zone reaches Costa Rica resulting in a notable depletion in isotope ratios (up to -18.5‰ d18O). HYSPLIT back air mass trajectories indicate the strong influence on the origin and transport of precipitation of two main moisture transport mechanisms, the Caribbean Low Level Jet and the Colombian Low Level Jet as well as localized convection events. Multiple linear regression models constructed based on Random Forests of surface meteorological information and atmospheric sounding profiles suggest that Lifted Condensation Level and surface relative humidity are the main factors controlling isotopic variations. These findings diverge from the recognized 'amount effect' in monthly composite samples across the tropics. Understanding of stable isotope dynamics in tropical precipitation can be used to enhance catchment and groundwater modeling efforts in ungauged basins where scarcity of long-term monitoring data drastically limit current and future water resources management.

  9. Coliform risk assessment through use of the clam Anomalocardia brasiliana as animal sentinel for shellfish harvesting areas in Brazil's northeast.

    PubMed

    Lima-Filho, José Vitor; Interaminense, Juliana A; Batista, Jacqueline E; Vaz, Renata V; Ventura, Roberta F; Oliveira, Isabella B; Soares, Roberta B; Peixoto, Sílvio M

    2015-08-01

    Outbreaks of food-borne diseases related to consumption of contaminated shellfish have been reported in many countries, but not in Brazil, possibly due to deficient reporting. Here we investigated the suitability of the clam Anomalocardia brasiliana as an animal sentinel for coliform monitoring in shellfish harvesting areas of Brazil's northeast. Samples of shellfish meats (40 clams per sample; n = 8 per collection) were collected at random from April 2009 through March 2010 in the bay area of Mangue Seco (state of Pernambuco). The numbers of thermotolerant coliforms were analyzed through the most probable number technique, and these contamination levels were tentatively correlated with the precipitation recorded on the day of sampling or 24 to 48 h beforehand. A. brasiliana shellfish meats from local retail shops (250 g per sample/ n = 3 per market) sold frozen were also investigated from August 2010 through June 2011. We found that the highest coliform contamination levels were correlated with recent rainfall events, limited to 24 h before sampling. However, irrespective of the rainfall level, the mean contamination above the Brazilian legal threshold of < 3 × 10(2) MPN/ 100 g for shellfish harvesting areas ranged from 18.7 to 93.7 % of samples analyzed monthly. Additionally, a large number of samples obtained from retail shops were also highly contaminated by coliforms during rainy periods, and therefore were not proper for human consumption. We conclude that A. brasiliana can be successfully used to monitor the contamination levels of coliforms in shellfish harvesting areas in Brazil's northeast coast.

  10. Preliminary Evaluation of Removing Used Nuclear Fuel from Shutdown Sites

    SciTech Connect

    Maheras, Steven J.; Best, Ralph E.; Ross, Steven B.; Buxton, Kenneth A.; England, Jeffery L.; McConnell, Paul E.; Massaro, Lawrence M.; Jensen, Philip J.

    2015-09-30

    A preliminary evaluation of removing spent nuclear fuel (SNF) from 13 shutdown nuclear power reactor sites was conducted. At these shutdown sites the nuclear power reactors have been permanently shut down and the sites have been decommissioned or are undergoing decommissioning. The shutdown sites were Maine Yankee, Yankee Rowe, Connecticut Yankee, Humboldt Bay, Big Rock Point, Rancho Seco, Trojan, La Crosse, Zion, Crystal River, Kewaunee, San Onofre, and Vermont Yankee. The evaluation was divided into four components: (1) characterization of the SNF and greater-than-Class C low-level radioactive waste (GTCC waste) inventory, (2) a description of the on-site infrastructure and conditions relevant to transportation of SNF and GTCC waste, (3) an evaluation of the near-site transportation infrastructure and experience relevant to shipping transportation casks containing SNF and GTCC waste, including identification of gaps in information, and (4) an evaluation of the actions necessary to prepare for and remove SNF and GTCC waste. Every site was found to have at least one off-site transportation mode option for removing its SNF and GTCC waste; some have multiple options. Experience removing large components during reactor decommissioning provided an important source of information used to identify the transportation mode options for the sites. Especially important in conducting the evaluation were site visits, through which information was obtained that would not have been available otherwise. Extensive photographs taken during the site visits proved to be particularly useful in documenting the current conditions at or near the sites. It is expected that additional site visits will be conducted to add to the information presented in the evaluation.

  11. The effects of wildfire on the sediment yield of a coastal California watershed

    USGS Publications Warehouse

    Warrick, J.A.; Hatten, J.A.; Pasternack, G.B.; Gray, A.B.; Goni, M.A.; Wheatcroft, R.A.

    2012-01-01

    The occurrence of two wildfires separated by 31 yr in the chaparral-dominated Arroyo Seco watershed (293 km) of California provides a unique opportunity to evaluate the effects of wildfire on suspended-sediment yield. Here, we compile discharge and suspended-sediment sampling data from before and after the fires and show that the effects of the postfire responses differed markedly. The 1977 Marble Cone wildfire was followed by an exceptionally wet winter, which resulted in concentrations and fluxes of both fine and coarse suspended sediment that were ˜35 times greater than average (sediment yield during the 1978 water year was 11,000 t/km2/yr). We suggest that the combined 1977–1978 fire and flood had a recurrence interval of greater than 1000 yr. In contrast, the 2008 Basin Complex wildfire was followed by a drier than normal year, and although suspended-sediment fluxes and concentrations were significantly elevated compared to those expected for unburned conditions, the sediment yield during the 2009 water year was less than 1% of the post–Marble Cone wildfire yield. After the first postfire winters, sediment concentrations and yield decreased with time toward prefire relationships and continued to have significant rainfall dependence. We hypothesize that the differences in sediment yield were related to precipitation-enhanced hillslope erosion processes, such as rilling and mass movements. The millennial-scale effects of wildfire on sediment yield were explored further using Monte Carlo simulations, and these analyses suggest that infrequent wildfires followed by floods increase long-term suspended-sediment fluxes markedly. Thus, we suggest that the current approach of estimating sediment yield from sediment rating curves and discharge data—without including periodic perturbations from wildfires—may grossly underestimate actual sediment yields.

  12. Crystal structure of tetra-kis-[μ2-2-(di-methyl-amino)-ethano-lato-κ(3) N,O:O]di-μ3-hydroxido-di-thio-cyanato-κ(2) N-dichromium(III)dilead(II) di-thio-cyanate aceto-nitrile monosolvate.

    PubMed

    Rusanova, Julia A; Semenaka, Valentyna V; Omelchenko, Irina V

    2016-04-01

    The tetra-nuclear complex cation of the title compound, [Cr2Pb2(NCS)2(OH)2(C4H10NO)4](SCN)2·CH3CN, lies on an inversion centre. The main structural feature of the cation is a distorted seco-norcubane Pb2Cr2O6 cage with a central four-membered Cr2O2 ring. The Cr(III) ion is coordinated in a distorted octa-hedron, which involves two N atoms of one bidentate ligand and one thio-cyanate anion, two μ2-O atoms of 2-(di-methyl-amino)-ethano-late ligands and two μ3-O atoms of hydroxide ions. The coordination geometry of the Pb(II) ion is a distorted disphenoid, which involves one N atom, two μ2-O atoms and one μ3-O atom. In addition, weak Pb⋯S inter-actions involving the coordinating and non-coordinating thio-cyanate anions are observed. In the crystal, the complex cations are linked through the thio-cyanate anions via the Pb⋯S inter-actions and O-H⋯N hydrogen bonds into chains along the c axis. The chains are further linked together via S⋯S contacts. The contribution of the disordered solvent aceto-nitrile mol-ecule was removed with the SQUEEZE [Spek (2015 ▸). Acta Cryst. C71, 9-18] procedure in PLATON. The solvent is included in the reported mol-ecular formula, weight and density.

  13. [Eating habits and attitudes towards change in Spanish university students and workers].

    PubMed

    Zazpe, Itziar; Marqués, María; Sánchez-Tainta, Ana; Rodríguez-Mourille, Ana; Beunza, Juan-José; Santiago, Susana; Fernández-Montero, Alejandro

    2013-01-01

    Introducción: El entorno educativo y laboral ha adquirido protagonismo como ámbito prometedor para llevar a cabo intervenciones nutricionales en población adulta. Objetivos: El objetivo de este trabajo es evaluar los hábitos alimentarios y actitudes hacia el cambio en trabajadores y alumnos universitarios con distinto perfil académico. Métodos: Estudio epidemiológico descriptivo de tipo transversal en población universitaria española de 1.429 sujetos. Se analizaron los hábitos alimentarios y las actitudes hacia el cambio de hábitos. Resultados: La edad media de los trabajadores fue de 37 años y en los estudiantes de 23 años. En ambos grupos el fraccionamiento de la ingesta más frecuente fue de cuatro tomas al día. En los alumnos se observó menor frecuencia de consumo de verdura, vino, pescado y frutos secos y mayor de bebidas carbonatadas, repostería comercial, fast-food y carnes rojas. Por otro lado, en general los hábitos alimentarios de los estudiantes de ciencias fueron más saludables que los de letras. Aunque no se observaron diferencias significativas en las actitudes hacia el cambio entre estudiantes y trabajadores, el 32% de los empleados y el 39% de los estudiantes afirmaron estar planteándose seriamente cambiar sus costumbres. Conclusiones: El patrón alimentario fue más saludable entre los trabajadores que entre los alumnos, especialmente en aquellos que cursan grados de letras, que constituyen el grupo más vulnerable desde el punto de vista nutricional. Además, aproximadamente un tercio de los trabajadores y alumnos se planteaba modificar sus hábitos.

  14. Pre- and post-fire pollutant loads in an urban fringe watershed in Southern California.

    PubMed

    Burke, M P; Hogue, T S; Kinoshita, A M; Barco, J; Wessel, C; Stein, E D

    2013-12-01

    Post-fire runoff has the potential to be a large source of contaminants to downstream areas. However, the magnitude of this effect in urban fringe watersheds adjacent to large sources of airborne contaminants is not well documented. The current study investigates the impacts of wildfire on stormwater contaminant loading from the upper Arroyo Seco watershed, burned in 2009. This watershed is adjacent to the Greater Los Angeles, CA, USA area and has not burned in over 60 years. Consequently, it acts as a sink for regional urban pollutants and presents an opportunity to study the impacts of wildfire. Pre- and post-fire storm samples were collected and analyzed for basic cations, trace metals, and total suspended solids. The loss of vegetation and changes in soil properties from the fire greatly increased the magnitude of storm runoff, resulting in sediment-laden floods carrying high concentrations of particulate-bound constituents. Post-fire concentrations and loads were up to three orders of magnitude greater than pre-fire values for many trace metals, including lead and cadmium. A shift was also observed in the timing of chemical delivery, where maximum suspended sediment, trace metal, and cation concentrations coincided with, rather than preceded, peak discharge in the post-fire runoff, amplifying the fire's impacts on mass loading. The results emphasize the importance of sediment delivery as a primary mechanism for post-fire contaminant transport and suggest that traditional management practices that focus on treating only the early portion of storm runoff may be less effective following wildfire. We also advocate that watersheds impacted by regional urban pollutants have the potential to pose significant risk for downstream communities and ecosystems after fire. PMID:23912423

  15. A review on phytochemical, pharmacological, and pharmacognostical profile of Wrightia tinctoria: Adulterant of kurchi.

    PubMed

    Srivastava, Rajani

    2014-01-01

    Wrightia tinctoria R. Br. belongs to family Apocynaceae commonly called as Sweet Indrajao, Pala Indigo Plant, Dyer's Oleander. "Jaundice curative tree" in south India. Sweet Indrajao is a small, deciduous tree with a light gray, scaly smooth bark. Native to India and Burma, Wrightia is named after a Scottish physician and botanist William Wright (1740-1827). Sweet Indrajao is called dhudi (Hindi) because of its preservative nature. The juice of the tender leaves is used efficaciously in jaundice. Crushed fresh leaves when filled in the cavity of decayed tooth relieve toothache. In Siddha system of medicine, it is used for psoriasis and other skin diseases. Oil 777 prepared out of the fresh leaves of the plant has been assigned to analgesic, anti-inflammatory, and anti-pyretic activities and to be effective in the treatment of psoriasis. The plant is reported to contain presence of flavanoid, glycoflavones-iso-orientin, and phenolic acids. The various chemical constituents isolated from various parts of the plant are reported as 3,4-Seco-lup-20 (29)-en-3-oic acid, lupeol, stigmasterol and campetosterol, Indigotin, indirubin, tryptanthrin, isatin, anthranillate and rutin Triacontanol, Wrightial, cycloartenone, cycloeucalenol, β-amyrin, Alpha-Amyrin, and β-sitosterol, 14α-methylzymosterol. Four uncommon sterols, desmosterol, clerosterol, 24-methylene-25-methylcholesterol, and 24-dehydropollinastanol, were isolated and identified in addition to several more common phytosterols. The Triterpinoids components of the leaves and pods of Wrightia tinctoria also isolated. This article intends to provide an overview of the chemical constituents present in various parts of the plants and their pharmacological actions and pharmacognostical evaluation.

  16. Characterization and Functional Identification of a Novel Plant 4,5-Extradiol Dioxygenase Involved in Betalain Pigment Biosynthesis in Portulaca grandiflora

    PubMed Central

    Christinet, Laurent; Burdet, Frédéric X.; Zaiko, Maïa; Hinz, Ursula; Zrÿd, Jean-Pierre

    2004-01-01

    Betalains are pigments that replace anthocyanins in the majority of families of the plant order Caryophyllales. Betalamic acid is the common chromophore of betalains. The key enzyme of the betalain biosynthetic pathway is an extradiol dioxygenase that opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. A gene for a 4,5-DOPA-dioxygenase has already been isolated from the fungus Amanita muscaria, but no homolog was ever found in plants. To identify the plant gene, we constructed subtractive libraries between different colored phenotypes of isogenic lines of Portulaca grandiflora (Portulacaceae) and between different stages of flower bud formation. Using in silico analysis of differentially expressed cDNAs, we identified a candidate showing strong homology at the level of translated protein with the LigB domain present in several bacterial extradiol 4,5-dioxygenases. The gene was expressed only in colored flower petals. The function of this gene in the betalain biosynthetic pathway was confirmed by biolistic genetic complementation in white petals of P. grandiflora genotypes lacking the gene for color formation. This gene named DODA is the first characterized member of a novel family of plant dioxygenases phylogenetically distinct from Amanita sp. DOPA-dioxygenase. Homologs of DODA are present not only in betalain-producing plants but also, albeit with some changes near the catalytic site, in other angiosperms and in the bryophyte Physcomitrella patens. These homologs are part of a novel conserved plant gene family probably involved in aromatic compound metabolism. PMID:14730069

  17. Crystal structure of tetra-kis-[μ2-2-(di-methyl-amino)-ethano-lato-κ(3) N,O:O]di-μ3-hydroxido-di-thio-cyanato-κ(2) N-dichromium(III)dilead(II) di-thio-cyanate aceto-nitrile monosolvate.

    PubMed

    Rusanova, Julia A; Semenaka, Valentyna V; Omelchenko, Irina V

    2016-04-01

    The tetra-nuclear complex cation of the title compound, [Cr2Pb2(NCS)2(OH)2(C4H10NO)4](SCN)2·CH3CN, lies on an inversion centre. The main structural feature of the cation is a distorted seco-norcubane Pb2Cr2O6 cage with a central four-membered Cr2O2 ring. The Cr(III) ion is coordinated in a distorted octa-hedron, which involves two N atoms of one bidentate ligand and one thio-cyanate anion, two μ2-O atoms of 2-(di-methyl-amino)-ethano-late ligands and two μ3-O atoms of hydroxide ions. The coordination geometry of the Pb(II) ion is a distorted disphenoid, which involves one N atom, two μ2-O atoms and one μ3-O atom. In addition, weak Pb⋯S inter-actions involving the coordinating and non-coordinating thio-cyanate anions are observed. In the crystal, the complex cations are linked through the thio-cyanate anions via the Pb⋯S inter-actions and O-H⋯N hydrogen bonds into chains along the c axis. The chains are further linked together via S⋯S contacts. The contribution of the disordered solvent aceto-nitrile mol-ecule was removed with the SQUEEZE [Spek (2015 ▸). Acta Cryst. C71, 9-18] procedure in PLATON. The solvent is included in the reported mol-ecular formula, weight and density. PMID:27375871

  18. Integrated exploration workflow in the south Middle Magdalena Valley (Colombia)

    NASA Astrophysics Data System (ADS)

    Moretti, Isabelle; Charry, German Rodriguez; Morales, Marcela Mayorga; Mondragon, Juan Carlos

    2010-03-01

    The HC exploration is presently active in the southern part of the Middle Magdalena Valley but only moderate size discoveries have been made up to date. The majority of these discoveries are at shallow depth in the Tertiary section. The structures located in the Valley are faulted anticlines charged by lateral migration from the Cretaceous source rocks that are assumed to be present and mature eastward below the main thrusts and the Guaduas Syncline. Upper Cretaceous reservoirs have also been positively tested. To reduce the risks linked to the exploration of deeper structures below the western thrusts of the Eastern Cordillera, an integrated study was carried out. It includes the acquisition of new seismic data, the integration of all surface and subsurface data within a 3D-geomodel, a quality control of the structural model by restoration and a modeling of the petroleum system (presence and maturity of the Cretaceous source rocks, potential migration pathways). The various steps of this workflow will be presented as well as the main conclusions in term of source rock, deformation phases and timing of the thrust emplacement versus oil maturation and migration. Our data suggest (or confirm) The good potential of the Umir Fm as a source rock. The early (Paleogene) deformation of the Bituima Trigo fault area. The maturity gap within the Cretaceous source rock between the hangingwall and footwall of the Bituima fault that proves an initial offset of Cretaceous burial in the range of 4.5 km between the Upper Cretaceous series westward and the Lower Cretaceous ones eastward of this fault zone. The post Miocene weak reactivation as dextral strike slip of Cretaceous faults such as the San Juan de Rio Seco fault that corresponds to change in the Cretaceous thickness and therefore in the depth of the thrust decollement.

  19. Cytoskeletal toxicity of pectenotoxins in hepatic cells

    PubMed Central

    Espiña, B; Louzao, M C; Ares, I R; Cagide, E; Vieytes, M R; Vega, F V; Rubiolo, J A; Miles, C O; Suzuki, T; Yasumoto, T; Botana, L M

    2008-01-01

    Background and purpose. Pectenotoxins are macrocyclic lactones found in dinoflagellates of the genus Dinophysis, which induce severe liver damage in mice after i.p. injection. Here, we have looked for the mechanism(s) underlying this hepatotoxicity. Experimental approach. Effects of pectenotoxin (PTX)-1, PTX-2, PTX-2 seco acid (PTX-2SA) and PTX-11 were measured in a hepatocyte cell line with cancer cell characteristics (Clone 9) and in primary cultures of rat hepatocytes. Cell morphology was assessed by confocal microscopy; F- and G-actin were selectively stained and cell viability measured by Alamar Blue fluorescence. Key results. Clone 9 cells and primary hepatocytes showed a marked depolymerization of F-actin with PTX-1, PTX-2 and PTX-11 (1–1000 nM) associated with an increase in G-actin level. However, morphology was only clearly altered in Clone 9 cells. PTX-2SA had no effect on the actin cytoskeleton. Despite the potent F-actin depolymerizing effect, PTX-1, PTX-2 or PTX-11 did not decrease the viability of Clone 9 cells after 24-h treatment. Only prolonged incubation (>48 h) with PTXs induced a fall in viability, and under these conditions, morphology of both Clone 9 and primary hepatocytes was drastically changed. Conclusions and implications. Although the actin cytoskeleton was clearly altered by PTX-1, PTX-2 and PTX-11 in the hepatocyte cell line and primary hepatocytes, morphological assessments indicated a higher sensitivity of the cancer-like cell line to these toxins. However, viability of both cell types was not altered. PMID:18776914

  20. The effect of methyl jasmonate on triterpene and sterol metabolisms of Centella asiatica, Ruscus aculeatus and Galphimia glauca cultured plants.

    PubMed

    Mangas, Susana; Bonfill, Mercè; Osuna, Lidia; Moyano, Elisabeth; Tortoriello, Jaime; Cusido, Rosa M; Piñol, M Teresa; Palazón, Javier

    2006-09-01

    Considering that exogenously applied methyl jasmonate can enhance secondary metabolite production in a variety of plant species and that 2,3-oxidosqualene is a common precursor of triterpenes and sterols in plants, we have studied Centella asiatica and Galphimia glauca (both synthesizing triterpenoid secondary compounds) and Ruscus aculeatus (which synthesizes steroidal secondary compounds) for their growth rate and content of free sterols and respective secondary compounds, after culturing with or without 100 microM methyl jasmonate. Our results show that elicited plantlets of G. glauca and to a higher degree C. asiatica (up to 152-times more) increased their content of triterpenoids directly synthesized from 2,3-oxidosqualene (ursane saponins and nor-seco-friedelane galphimines, respectively) at the same time as growth decreased. In contrast, the free sterol content of C. asiatica decreased notably, and remained practically unaltered in G. glauca. However, in the case of R. aculeatus, which synthesizes steroidal saponins (mainly spirostane type) indirectly from 2,3-oxidosqualene after the latter is converted to the plant phytosterol-precursor cycloartenol, while the growth rate and free sterol content clearly decreased, the spirostane saponine content was virtually unchanged (aerial part) or somewhat lower (roots) in presence of the same elicitor concentration. Our results suggest that while methyl jasmonate may be used as an inducer of enzymes involved in the triterpenoid synthesis downstream from 2,3-oxidosqualene in both C. asiatica and G. glauca plantlets, in those of C. asiatica and R. aculeatus it inhibited the enzymes involved in sterol synthesis downstream from cycloartenol. PMID:16876832

  1. Geology and ground-water hydrology of the Mokelumne area, California

    USGS Publications Warehouse

    Piper, A.M.; Gale, H.S.; Thomas, H.E.; Robinson, T.W.

    1939-01-01

    The Mokelumne River basin of central California comprises portions of the California Trough and the Sierra Nevada section of the Pacific Mountain system. The California Trough is divisible into four subsections-the Delta tidal plain, the Victor alluvial plain, tlie river flood plains and channels, and the Arroyo Seco dissected pediment. These four subsections comprise the land forms produced by the Mokelumne River and other streams since the Sierra Nevada attained its present height in the Pleistocene epoch. The Victor alluvial plain rises eastward from the Delta plain and abuts on the dissected Arroyo Seco pediment; in the Mokelumne area it is 12 to 16 miles wide and slopes between 5 and 8 feet in a mile. It includes relatively extensive tracts that are intensively cultivated and irrigated with water pumped from wells. The Victor plain has been compounded of overlapping alluvial fans along the western base of the Sierra Nevada. It is prolonged eastward into the pediment by tongues of alluvium along several of the present streams; thus it seems likely that the present stream pattern in the eastern part of the area has been fixed since dissection of the pediment began. Three of the four major streams-the Mokelumne and Cosumnes Rivers and Dry Creek-traverse the Victor plain in trenches which are 15 to 40 feet deep at the heads of their respective alluvial fans but which die out toward the west. The floors of these trenches, the historic flood plains, are from 100 yards to a mile wide. The exceptional major stream, which has not entrenched itself, is the Calaveras River. The Arroyo Seco pediment, which lies east of the Victor plain, was initially at least 8 to 15 miles wide and lay along the western foot of the Sierra Nevada entirely .across the Mokelumne area. Its numerous remnants decline 15 to 35 feet in a mile toward the west. The Sierra Nevada section adjoins and lies east of the California Trough. Its major ridge crests define a volcanic plain whose westward

  2. Flow paths in the Edwards aquifer, northern Medina and northeastern Uvalde counties, Texas, based on hydrologic identification and geochemical characterization and simulation

    USGS Publications Warehouse

    Clark, Allan K.; Journey, Celeste A.

    2006-01-01

    The U.S. Geological Survey, in cooperation with the San Antonio Water System, conducted a 4-year study during 2001– 04 to identify major ground-water flow paths in the Edwards aquifer in northern Medina and northeastern Uvalde Counties, Texas. The study involved use of geologic structure, surfacewater and ground-water data, and geochemistry to identify ground-water flow paths. Relay ramps and associated faulting in northern Medina County appear to channel ground-water flow along four distinct flow paths that move water toward the southwest. The northwestern Medina flow path is bounded on the north by the Woodard Cave fault and on the south by the Parkers Creek fault. Water moves downdip toward the southwest until the flow encounters a cross fault along Seco Creek. This barrier to flow might force part or most of the flow to the south. Departure hydrographs for two wells and discharge departure for a streamflow-gaging station provide evidence for flow in the northwestern Medina flow path. The north-central Medina flow path (northern part) is bounded by the Parkers Creek fault on the north and the Medina Lake fault on the south. The adjacent north-central Medina flow path (southern part) is bounded on the north by the Medina Lake fault and on the south by the Diversion Lake fault. The north-central Medina flow path is separated into a northern and southern part because of water-level differences. Ground water in both parts of the northcentral Medina flow path moves downgradient (and down relay ramp) from eastern Medina County toward the southwest. The north-central Medina flow path is hypothesized to turn south in the vicinity of Seco Creek as it begins to be influenced by structural features. Departure hydrographs for four wells and Medina Lake and discharge departure for a streamflow-gaging station provide evidence for flow in the north-central Medina flow path. The south-central Medina flow path is bounded on the north by the Seco Creek and Diversion Lake faults

  3. Interactions of grass spontaneous cover in olive orchards with site conditions and management: a study case using biodiversity indices

    NASA Astrophysics Data System (ADS)

    Arroyo, Carmen; Taguas, Encarnación; Lora, Ángel; Guzmán, Gema; Vanderlinden, Karl; Gómez, Jose A.

    2014-05-01

    Spontaneous herbaceous plants are an inexpensive control measure of soil erosion in olive orchards. Grass covers on steep areas are a requirement for compliance by farmers with basic standards concerning the environment, derived from Common Agricultural Policy (cross-compliances). In addition to ground cover, other aspects such as biodiversity and OC storage capacity of these systems are often not considered, despite the fact that the occupation of many ecological niches by different species might provide substantial environmental and landscape benefits. In this study, we evaluated different biodiversity indices on grass cover in two olive orchard catchments with different managements (conventional tillage and non-tillage with natural herbaceous plants) during 3 years (2011-2013). Seasonal samples of vegetal material and pictures in a permanent grid (4 samples/ha) were taken to characterize the temporal variations of the indicators: number of species, frequency, diversity and transformed Shanon's and Pielou's indices. The specific objectives of this work were: i) to describe and to compare the biodiversity indices in two contrasting olive orchard catchments of 6 and 9 ha with different soil types, precipitation, topography and management; ii) to explore possible relationships of these indexes with soil organic carbon content and soil loss. The results will allow improving our knowledge of environmental functions of this type of ground cover as well as factors determining its development. These features can be particularly interesting to enhance the environmental values of marginal olive orchards in steep locations. REFERENCES Aguilera L. 2012.Estudio de cubiertas vegetales para el control de la erosión en olivar Evolución espacio-temporal en dos fincas comerciales, y exploración de nuevas opciones de cubiertas. Master Thesis. University of Cordoba (Spain) Gimeno E. 2011. Análisis de la variabilidad de la cobertura vegetal en tres pequeñas cuencas de olivar

  4. [Probiotics: from the lab to the consumer].

    PubMed

    Rodríguez, J M

    2015-02-07

    Introducción: En los últimos años, el campo de los probióticos ha experimentado un gran auge. Sin embargo, de los miles de cepas aisladas cada año por su potencial probiótico en los laboratorios de todo el mundo, muy pocas pasan a una fase de desarrollo industrial y menos aún son las que consiguen una vida comercial. Objetivo: En este artículo, se revisan los principales aspectos que se deben tener en cuenta en el, habitualmente, largo y tortuoso camino que debe seguir una cepa desde su aislamiento inicial hasta su comercialización. Resultados y conclusiones: Cualquier microorganismo probiótico debe estar correctamente identificado a nivel de especie y cepa. La secuencia del genoma es la mejor identificación posible, además de proporcionar información muy valiosa sobre su seguridad, funcionalidad y propiedades de interés tecnológico. Los casos en los que se ha podido establecer una relación entre un probiótico y un efecto adverso son muy escasos y han afectado a personas con patologías subyacentes. Globalmente, aunque las distintas pruebas in vitro, ex vivo y en modelos animales proporcionan información útil durante el proceso de selección de cepas, los únicos datos que permiten evaluar la seguridad y eficacia de un probiótico de una forma directa son los que se obtienen en el curso de ensayos clínicos correctamente diseñados y dirigidos específicamente a la población diana. Por otra parte, las empresas que comercializan probióticos tienen la necesidad de obtener una biomasa muy elevada de forma económicamente rentable y de que la concentración de bacterias viables necesaria para ejercer el efecto beneficioso se mantenga hasta el final de la vida útil del producto. Finalmente, los aspectos comerciales son determinantes en la decisión de afrontar el desarrollo industrial y la puesta en el mercado de un probiótico.

  5. Food intake reported versus nursing records: is there agreement in surgical patients?

    PubMed

    Braga Azambuja, Fernanda; Beghetto, Mariur Gomes; de Assis, Michelli Cristina Silva; de Mello, Elza Daniel

    2015-06-01

    Objetivo: evaluar la concordancia entre la aceptacion de la dieta oral reportada por los pacientes y los registros en prontuario de esta aceptacion. Método: fueron evaluados el consumo de alimentos y los registros de la ingestion en prontuario por las enfermeras. Se considero “buena aceptacion”: la ingesta de ≥ 75% de las calorias totales prescritas por dia, “regular aceptacion”: de 50 a 74,9%; “baja aceptacion”: < 50% y NPO (nada por la boca). Para la evaluacion de la concordancia fue utilizado el coeficiente Kappa. Resultados: la proporcion de respuestas coincidentes entre el relato del paciente y el registro de las enfermeras fue 91,3% en casos de NPO, 87,1% para “buena aceptacion”, 17,8% para “regular aceptacion” y 16.5% para “baja aceptacion” (Kappa = 0,45). Conclusión: la concordancia entre los relatos de los pacientes y los registros de las enfermeras fue de moderada a debil. Hubo una mayor proporcion de respuestas coincidentes cuando los pacientes informaron “buena aceptacion” o cuando habia NPO prescrito.

  6. [Independent ethics committees for clinical research in Argentina. An evaluation and a system to guarantee their independence].

    PubMed

    Gonorazky, Sergio E

    2008-01-01

    The Administración Nacional de Medicamentos, Alimentos y Tecnología Médica de la República Argentina (ANMAT) requires that an independent ethics committee of sponsors and/or researchers must previously evaluate and approve all the new pharmacological research protocols carried out on human beings. However, due to the lucrative nature of the evaluation, and because the selection of the Independent Ethics Committee is carried out by the sponsors and/or researchers, the assumed autonomy of the former can be reduced to merely a relationship of "service provider-customer". The Institutional Review Board of the Mar del Plata s Community Hospital has evaluated, between 2005 and 2006, thirty three research protocols (with their corresponding information sheets for patients and informed consent forms) previously approved by a non-institutional Independent Ethics Committee. The median number of objections made by the Institutional Review Board, which prompted the previously mentioned protocols to be modified in order to be approved, was of three per protocol. In other words, the accreditation of an Independent Ethics Committee requires a system that guarantees actual independence from the sponsors and/or researchers, as well as management control mechanisms that may lead them into an eventual loss of accreditation. Several measures are proposed in order to correct the deficiencies of the present system.

  7. [Thirty Years of Health Surveillance of Foods in Barcelona: The "ICSA" Food Quality Research Program].

    PubMed

    Fontcuberta-Famadas, Mireia; Rodellar-Torras, Santiago; Portaña-Tudela, Samuel; Durán-Neira, Julia

    2015-01-01

    The Food Health Quality Research Program (Investigación de la Calidad Sanitaria de los Alimentos [ICSA]) of the Public Health Agency of Barcelona (Agencia de Salud Pública de Barcelona [ASPB]) was initiated in 1984 to carry out surveillance of certain chemical and microbiological parameters related to the sanitary and safety of foods sold in the city. The present article analyzes the importance of health surveillance and provides details of the uses of the ICSA program. The main aim of this program is to evaluate whether marketed foods comply with the absence and/or established tolerance levels of specific parameters. Nevertheless, the program is able to incorporate or suppress parameters or foods that pose emerging dangers or interests not represented in current legislation. Besides, the program not only obtains a view of the parameters studied at a specific time period in each report, but also accumulates data over time, allowing risk assessment, calculation of dietary intake of contaminants, analysis of tendencies, and evaluation of the effectiveness of regulations to reduce contaminants. The program can also help in the planning of food control programs. The information obtained is disseminated nationally and internationally and is included in dossiers of contaminants issued by national and European health agencies. This demonstrates that a locally-developed surveillance system can have a wider scope and broader objectives and can provide useful information for managers, administrations, economic operators and consumers.

  8. Milk and dairy products intake in child-juvenile population in Navarre, Spain.

    PubMed

    Durá-Travé, Teodoro; Gallinas-Victoriano, Fidel

    2014-10-01

    Objetivo: Realizar un estudio descriptivo del consumo de leche y derivados lácteos en una población de escolares y adolescentes y analizar su contribución nutricional en la dieta de estos jóvenes. Material y Métodos: Registro de consumo de alimentos de tres días lectivos consecutivos en una muestra de 353 alumnos que cursaban Educación Primaria, entre 9 y 12 años de edad; y a 406 alumnos que cursaban Educación Secundaria Obligatoria, entre 13 y 16 años, en la ciudad de Pamplona (Navarra, España). Resultados: El 94% de los encuestados referían haber tomado lácteos en el desayuno y, en menor proporción, en la cena (69,3%), comida del mediodía (42,1%), merienda (23,3%) y almuerzo (16,4%). No existían diferencias estadísticamente significativas entre los grupos de edad. El valor medio del número de raciones de lácteos consumidas por la totalidad de los encuestados era de 2 diarias, siendo significativamente superior (p.

  9. [Lipid - lowering effect of mate tea intake in dyslipidemic subjects].

    PubMed

    Messina, Diego; Soto, Catalina; Méndez, Ailín; Corte, Carla; Kemnitz, Mariana; Avena, Virginia; Del Balzo, Diego; Pérez Elizalde, Rafael

    2015-05-01

    Introducción: El mate es la infusión nacional de Argentina y sus propiedades en la salud humana no han sido totalmente aclaradas. Objetivos: Evaluar las modificaciones del perfil lipídico en pacientes dislipidémicos suplementados con yerba mate. Métodos: Se estudiaron 121 individuos dislipidémicos (Colesterol Total (CT), Colesterol LDL (CLDL) y/o Triglicéridos (TG) elevados) de ambos sexos (74 mujeres y 47 varones) entre 40 y 60 años, sin tratamiento hipolipemiante. Luego de seis semanas de abstinencia de mate, se analizó su perfil lipídico e índice aterogénico (IA), composición corporal a través de antropometría y consumo reciente de energía, nutrientes y grupos de alimentos a través de cuestionario de frecuencia de consumo. Se indicó el consumo diario de mate preparado con 50g o 100g de yerba mate. Se indicó no alterar hábitos alimentarios, tabaquismo, medicación ni ejercicio físico. Se repitieron las determinaciones luego de seis y doce semanas. El análisis estadístico se realizó mediante prueba T de Student para muestras relacionadas o prueba de Wilcoxon según normalidad de las variables (p.

  10. [Comparative study of habits in students before and during the university in northwest area of Madrid].

    PubMed

    Iglesias López, María Teresa; Cuesta Santa Teresa, Elvira; Sáez Crespo, Antonio

    2014-11-12

    Introducción: En la mayoria de los paises occidentales los jovenes, adoptan estilos de vida que afectan negativamente a su salud, incrementando de esta manera el riesgo de la aparicion prematura de enfermedades cronicas. Objetivo: Comparar los patrones de habitos en estudiantes preuniversitarios y universitarios en la zona noroeste de Madrid. Material y método: Estudio longitudinal descriptivo con estudiantes madrilenos de universidades madrilenas y colegios-institutos de la zona centro-oeste de Madrid capital, aceptando participar 1590 alumnos de ambos sexos preuniversitarios y universitarios: 653 varones (41,1%) y 937 mujeres (58,9%). Se clasifico a los estudiantes en grupos etarios, ≤ 17 anos y ≥ 18 anos Resultados: Se estudia el IMC, la actividad fisica, el consumo de alcohol y los habitos negativos en cuanto al consumo de alimentos. Casi el 80% presenta normo peso, son mas activos los preuniversitarios. Conclusión: Se han constatado diferencias entre sexos, que deben guiar las actuaciones de intervencion en cuanto a la actividad fisica o habitos, por lo que parece fundamental realizar programas de intervencion nutricional y psicosocial en los adolescentes y jovenes para prevenir y/o reducir el consumo de alcohol.

  11. [Frequency of eating away-from-home and quality of dietary carbohydrate and fat intake in the SUN Project].

    PubMed

    Villacis, Cecilia; Zazpe, Itziar; Santiago, Susana; De la Fuente-Arrillaga, Carmen; Bes-Rastrollo, Maira; Martínez-González, Miguel Angel

    2014-10-03

    Objetivo: Investigar la asociación entre la frecuencia de comidas fuera de casa (CFC) con a) la calidad de hidratos de carbono y b) la calidad de grasas. Materiales y métodos: Se evaluaron 19.371 participantes de la cohorte SUN que completaron un cuestionario basal de frecuencia de consumo de alimentos previamente validado. Se utilizaron los índices de calidad de hidratos de carbono (ICHC) en una escala de 4 a 20 y de grasas (ICG) en una escala de 0,62 a 5,92. En ambos casos, a mayor puntuación mayor calidad. Se utilizó la regresión lineal múltiple para determinar la asociación entre la frecuencia de CFC (4 categorías) y la puntuación de ambos índices, y la regresión logística para medir la asociación entre la frecuencia de CFC y un bajo ICHC o ICG (

  12. [Sensory evaluation of enteral nutritional supplements].

    PubMed

    Granell Vidal, Lina; Sánchez Juan, Carlos; Alfonso García, Antonio

    2014-07-01

    INTRODUCCIÓN Y OBJETIVOS: La nutrición enteral (NE) está indicada en pacientes que, aunque no pueden consumir suficientes cantidades de alimentos, mantienen una función del aparato digestivo suficiente para recibir, digerir y absorber nutrientes. Los Suplementos Orales Nutricionales (SON) son fórmulas nutricionalmente completas o incompletas (en función de que aporten o no todos los nutrientes necesarios para servir como única fuente de nutrientes), que completan una dieta oral insuficiente. Con este estudio se pretende valorar las características organolépticas de suplementos nutricionales orales hiperproteicos, normoproteicos y enriquecidos con fibra. MATERIAL Y MÉTODOS: Cata de SON, llevada a cabo en el Servicio de Endocrinología y Nutrición del Consorcio Hospital General Universitario de Valencia desde octubre de 2012 a febrero de 2013. Se evaluaron 137 SON en total, de los cuales 47 eran hiperproteicos, 46 normoproteicos y 44 con fibra.

  13. [Familial microepidemic of food-borne botulism in the Region of Madrid].

    PubMed

    Jalda, D; Junco, A; Alvarez-Moreno, M; Rodero, I; Carneado-Ruiz, J

    2016-07-01

    Introduccion. El botulismo es un sindrome causado por la toxina del bacilo Clostridium botulinum. La toxina actua bloqueando las terminaciones colinergicas presinapticas de la placa motora y del sistema nervioso parasimpatico, y ocasiona una paralisis flacida y un fallo parasimpatico. El modo mas habitual de adquisicion de la enfermedad es por ingesta de toxina preformada presente en las conservas caseras mal esterilizadas, aunque otros mecanismos son posibles. Su incidencia actual en Espana es muy baja. Casos clinicos. Se describen tres miembros convivientes de una familia que presentaron un cuadro de botulismo alimentario. Las manifestaciones clinicas iniciales mostraron predileccion por la paresia ocular y por sintomatologia disautonomica de escasa especificidad, y la agregacion familiar fue el indicio fundamental que sugirio el diagnostico. Posteriormente, los pacientes empeoraron y dos de ellos presentaron afectacion de la funcion respiratoria y precisaron ingreso prolongado en la unidad de cuidados intensivos. Los tres pacientes convalecieron y se recuperaron sin secuelas. Se consiguio detectar la toxina botulinica por bioensayo en los restos de alimentos, lo que confiere al caso la categoria diagnostica de confirmado. Conclusiones. La microepidemia familiar presentada constituye un caso de afectacion inicial predominantemente ocular y disautonomica. Asimismo, ilustra varios aspectos tipicos de la enfermedad: la sospecha diagnostica ante pacientes convivientes que acuden simultaneamente por clinica similar, las complicaciones caracteristicas del proceso y su tratamiento, el diagnostico de laboratorio y su historia natural hacia la resolucion.

  14. [Food insecurity and social vulnerability in chiapas : the face of poverty].

    PubMed

    Martínez-Rodríguez, Julio C; García-Chong, Néstor R; Trujillo-Olivera, Laura E; Noriero-Escalante, Lucio

    2014-12-01

    Objetivo: estimar la frecuencia y distribución de seguridad o inseguridad alimentaria entre las familias en Chiapas, relacionar con condiciones de bienestar (CB) y características sociodemográficas. Método: Estudio transversal retrospectivo, descriptivo; incluye información proveniente de la Encuesta Nacional de Salud y Nutrición 2012 (ENSANUT 2012) en total 1,430 viviendas de Chiapas. La Inseguridad Alimentaria se midió usando la versión armonizada para México de la Escala Latinoamericana y Caribeña de Seguridad Alimentaria (ELCSA). Resultados: El 83% de los hogares en Chiapas tiene algún tipo de inseguridad alimentaria; 86.5% se concentra en los niveles socioeconómicos más bajos; sólo 15 de cada 100 hogares en zonas rurales registran seguridad alimentaria; 87% de los hogares beneficiarios de Oportunidades mantiene inseguridad para alimentarse. Discusión: Más de cuatro de cada cinco familias reportan inseguridad alimentaria, queda claro que los programas sociales focalizados destinados a abatir este rezago no impactan los niveles de acceso a los alimentos, lo que repercute en el potencial desarrollo físico e intelectual de los chiapanecos, convirtiéndose en un obstáculo más para el desarrollo de la entidad. Se plantea analizar y reorientar las políticas sociales.

  15. [PREVALENCE OF DEHYDRATION BEFORE TRAINING IN PROFESIONAL CHILEAN SOCCER PLAYERS].

    PubMed

    Castro-Sepúlveda, Mauricio; Astudillo, Sebastian; Álvarez, Cristian; Zapata-Lamana, Rafael; Zbinden-Foncea, Hermann; Ramírez-Campillo, Rodrigo; Jorquera, Carlos

    2015-07-01

    Introducción: existen pocos estudios relacionados con el estado de hidratación pre-entrenamiento en futbolistas profesionales. Objetivo: determinar la prevalencia de deshidratación pre-entrenamiento en jugadores profesionales de fútbol. Métodos: se incluyeron un total de 156 jugadores de fútbol (edad 25,4 ± 5,2 años) de seis clubes profesionales chilenos. No se hicieron recomendaciones previas de hidratación ni de ingesta de alimentos, con el objetivo de evaluar el estado de hidratación bajo condiciones regulares “reales”. Se evaluó la masa corporal, la talla y la gravedad específica de la orina (GEO) antes de sus sesiones de entrenamiento. Resultados: la deshidratación (entre moderada y grave) pre-entrenamiento se observó en el 98% de los futbolistas. Discusión: la deshidratación pre-entrenamiento es el estado de hidratación más frecuente en los jugadores profesionales de fútbol de Chile, lo que puede afectar negativamente a su rendimiento y podría incrementar su riesgo de lesiones relacionadas con el calor.

  16. [Depression and state of nutrition in schoolchildren from Sonora].

    PubMed

    López-Morales, Cruz Mónica; Pascalis-Orozco, Jennifer; Gonzalez-Heredia, Ricardo; Brito-Zurita, Olga Rosa; Sabag-Ruiz, Enrique

    2014-01-01

    INTRODUCCIÓN: la obesidad infantil se ha convertido en un problema cuyas proporciones son epidémicas, debido al consumo excesivo e inadecuado de alimentos, al sedentarismo y al limitado desarrollo socioeconómico. Esto ocasiona un mayor riesgo en complicaciones en la salud que repercuten en el ámbito psicológico y social del infante, lo cual lo lleva a padecer enfermedades como la depresión y la ansiedad. El objetivo de este estudio fue determinar la asociación entre la depresión y el estado de nutrición en escolares adscritos a una unidad de medicina familiar en Sonora. MÉTODOS: estudio transversal analítico que se llevó a cabo durante el 2011 en 101 escolares de Sonora. Se aplicó el test de Kovacs para detectar síntomas depresivos; se determinó el estado nutricional mediante peso y talla, y el cálculo del índice de masa corporal se hizo de acuerdo con los percentiles de las tablas del Centro para el Control y la Prevención de Enfermedades (CDC, por sus siglas en inglés) de Atlanta. El análisis de los resultados se realizó con U de Mann-Whitney y chi cuadrada en el programa SPSS, versión 18.

  17. Fructose intake: is there an association with uric acid levels in nondialysis-dependent chronic kidney disease patients?

    PubMed

    Vieira, Fernanda Oliveira; Leal, Viviane de Oliveira; Stockler-Pinto, Milena Barcza; Barros, Amanda de Faria; Borges, Natália Alvarenga; Lobo, Julie Calixto; Mafra, Denise

    2014-11-03

    Introducción: El consumo de fructosa ha aumentado dramáticamente en consecuencia del consumo de alimentos y bebidas azucaradas a base de fructosa. Pesquisas sugieren que el alto consumo de fructosa tiene una fuerte asociación con niveles de ácido úrico (AU) y empeora el pronóstico de la enfermedad renal crónica (ERC). Objetivo: El objetivo de este estudio fue investigar la influencia del consumo de fructosa en los niveles plasmáticos de ácido úrico en pacientes con ERC que no son dependiente de diálisis. Métodos: Cincuenta y dos pacientes en fases 3-5 (64,2±9,6 años, 24 hombres, tasa de filtración glomerular de 30,5±10,3ml/min) se dividieron en dos grupos: alto consumo de fructosa (>50g/día, n=29, 61,7± 9,3 años) y bajo consumo de fructosa (

  18. URINARY LOSS OF MICRONUTRIENTS IN DIABETIC PATIENTS ATTENDING A TERTIARY HOSPITAL SERVICE.

    PubMed

    da Silva Santos, Andressa Feijó; Souza Santos, Roberta Deh; Foss-Freitas, Maria Cristina; Carvalho da Cunha, Selma Freire; Marchini, Júlio Sérgio; Marques Miguel Suen, Vivian

    2015-08-01

    Introducción/objetivos: la deficiencia de micronutrientes puede contribuir a un menor control de la diabetes. El objetivo de este estudio fue evaluar la excreción urinaria de micronutrientes en pacientes con diabetes mellitus tipo 2. Métodos: los pacientes con diabetes y los controles fueron evaluados por la ingesta de alimentos, la antropometría, la pérdida urinaria de micronutrientes y comparados por Mann Whitney no paramétrico (p < 0,05). Resultados: fueron evaluados nueve sujetos diabéticos (52 ± 14 años con un IMC de 30 ± 11 kg/m² y la circunferencia de la cintura (CC) de 99 ± 25 cm) y nueve sujetos control (51 ± 16 años, IMC 26 ± 5 kg/m² y CA total de 90 ± 13 cm). La excreción de hierro más alta se observó en el grupo diabético y la mayor excreción de magnesio en el grupo de control. Conclusiones: el tipo 2 de pacientes diabéticos estudiados aquí no mostraron un aumento en la excreción de micronutrientes en la orina en comparación con los controles.

  19. Los plaguicidas y la contaminacion del medio ambiente Venezolano

    USGS Publications Warehouse

    Stickel, L.F.; Stickel, W.H.

    1972-01-01

    RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

  20. [Calibration tools menu and calculation of the composition nutritional food; validity and variability].

    PubMed

    San Mauro Martín, Ismael; Hernández Rodríguez, B

    2014-04-01

    Introducción: Las tablas de composición de alimentos (TCA) constituyen una herramienta básica para conocer el aporte de energía y la composición nutricional de los mismos. Objetivos: Demostrar mediante un menú modelo la variabilidad existente entre las distintas TCAs y bases de datos de los programas informáticos empleados. Métodos: Se calibró un menú con el programa Alimentador, y fue valorado posteriormente con los programas DIAL, EasyDiet, y con las TCAs de la RedBEDCA, CESNID, Mataix, 2003 y Moreiras O., 2013. Resultados: Muchos de los nutrientes no se pudieron comparar por la falta de datos. El rango de los datos comparables obtenidos para cada nutriente, difiere entre un 8% y un 84%, siendo mayor en micronutrientes que en macronutrientes o energía. Conclusión: Hemos demostrado la variabilidad entre las TCA y algunos programas informáticos, lo que resulta en cuestionarse la validez científica del uso de estas herramientas, tan habituales para profesionales de la nutrición.

  1. [Thirty Years of Health Surveillance of Foods in Barcelona: The "ICSA" Food Quality Research Program].

    PubMed

    Fontcuberta-Famadas, Mireia; Rodellar-Torras, Santiago; Portaña-Tudela, Samuel; Durán-Neira, Julia

    2015-01-01

    The Food Health Quality Research Program (Investigación de la Calidad Sanitaria de los Alimentos [ICSA]) of the Public Health Agency of Barcelona (Agencia de Salud Pública de Barcelona [ASPB]) was initiated in 1984 to carry out surveillance of certain chemical and microbiological parameters related to the sanitary and safety of foods sold in the city. The present article analyzes the importance of health surveillance and provides details of the uses of the ICSA program. The main aim of this program is to evaluate whether marketed foods comply with the absence and/or established tolerance levels of specific parameters. Nevertheless, the program is able to incorporate or suppress parameters or foods that pose emerging dangers or interests not represented in current legislation. Besides, the program not only obtains a view of the parameters studied at a specific time period in each report, but also accumulates data over time, allowing risk assessment, calculation of dietary intake of contaminants, analysis of tendencies, and evaluation of the effectiveness of regulations to reduce contaminants. The program can also help in the planning of food control programs. The information obtained is disseminated nationally and internationally and is included in dossiers of contaminants issued by national and European health agencies. This demonstrates that a locally-developed surveillance system can have a wider scope and broader objectives and can provide useful information for managers, administrations, economic operators and consumers. PMID:26388339

  2. [Consumption of carbonated beverages with nonnutritive sweeteners in Latin American university students].

    PubMed

    Durán Agüero, Samuel; Record Cornwall, Jiniva; Encina Vega, Claudia; Salazar de Ariza, Julieta; Cordón Arrivillaga, Karla; Cereceda Bujaico, María del Pilar; Antezana Alzamora, Sonia; Espinoza Bernardo, Sissy

    2014-09-12

    Introducción: El consumo de bebidas carbonatadas con edulcorantes no nutritivos (ENN) es cada vez más común con el objetivo de mantener un peso saludable, sin embargo el efecto de los ENN sobre el peso corporal es controversial. Materiales y métodos: Estudiantes universitarios (n=1.229) de ambos sexos de 18 a 26 años, de los cuales 472 de Chile, 300 de Panamá, 253 de Guatemala y 204 de Perú. A cada estudiante se le aplicó una encuesta de frecuencia de consumo semanal de alimentos apoyada con fotografías de bebidas con ENN para cada país para determinar la ingesta de ellos. Asimismo y se les realizó una evaluación antropométrica. Resultados: El 80% de los estudiantes consumían bebidas carbonatadas con ENN, ninguno de ellos superó la ingesta diaria admitida para sucralosa, acesulfame de potasio y aspartame. El mayor consumo tanto en hombres como mujeres se observó en estudiantes universitarios chilenos (p.

  3. [Diet and multiple sclerosis].

    PubMed

    Pozuelo-Moyano, Beatriz; Benito-León, Julián

    2014-05-16

    Introduccion. El tipo de dieta se ha relacionado con el proceso inflamatorio que forma parte de la esclerosis multiple (EM). En los ultimos años, distintas lineas de investigacion han generado una gran cantidad de conocimiento sobre la participacion de la dieta en la patogenesis de la EM. Objetivo. Elucidar de modo critico las evidencias que relacionan distintos tipos de dietas y alimentos con la EM. Desarrollo. Se incluye una actualizacion de los estudios publicados mas significativos que han analizado el papel de la dieta en la patogenesis y en el tratamiento de la EM. Para explorar la asociacion entre la dieta y el riesgo de EM se ha revisado la evidencia disponible hasta el momento, pasando por estudios observacionales hasta terminar con estudios de intervencion. Conclusiones. Se necesita mas investigacion sobre la nutricion como factor de riesgo, ya que podria tener relacion con la enfermedad, y el control de esta podria llevar a una disminucion significativa de la incidencia o progresion de la patologia.

  4. [Design and implementation of a questionnaire to evaluate the dietary quality of school meals].

    PubMed

    de Mateo Silleras, Beatriz; Camina Martín, M Alicia; Ojeda Sainz, Berta; Carreño Enciso, Laura; de la Cruz Marcos, Sandra; Marugán de Miguelsanz, José Manuel; Redondo del Río, Paz

    2014-10-03

    Introducción: El comedor escolar es el centro de comida habitual para muchos niños. Aunque actualmente se dispone de guías y recomendaciones para los menús escolares, resulta difícil evaluar su calidad dietética. Objetivos: Diseñar un cuestionario para evaluar la calidad desde el punto de vista dietético de los menús escolares de forma rápida y sencilla. Material y métodos: Partiendo de las recomendaciones, se ha diseñado un cuestionario (COMES) de 15 ítems que hacen referencia a la frecuencia de consumo de alimentos y otras características de los menús escolares. A continuación se realizó un estudio longitudinal prospectivo en el que se analizaron con este cuestionario 36 planillas de menús de 4 empresas de restauración colectiva que prestaban el servicio de comedor escolar en Castilla y León durante los cursos 2006-2007 a 2010-2011. Se analizaron las diferencias en función del sistema de gestión de las empresas mediante la prueba U de Mann-Whitney y el test de Kruskal- Wallis. La significación se alcanzó con una p.

  5. Adequacy of energy and nutrient intake in patients with heart failure.

    PubMed

    Sanches Machado d'Almeida, Karina; Dalira Schweigert Perry, Ingrid; Clausell, Nadine; Corrêa Souza, Gabriela

    2015-01-01

    Introducción: Factores nutricionales tienen una influencia significativa en el pronóstico de pacientes con insuficiencia cardíaca (IC). Objetivos: Evaluar la ingesta de alimentos de pacientes con IC estable. Métodos: Pacientes de ambos sexos, mayores de 18 años, con diagnóstico confirmado de IC fueron reclutados y emparejados por edad, sexo y IMC con individuos sanos. La ingesta nutricional fue evaluada mediante el registro alimentario y pesaje de acuerdo con las recomendaciones de las DRIs y NCEP-ATP III para la evaluación de la adecuación de la ingesta nutricional. Resultados: El 65% de los 40 pacientes con IC y el 48% de los 25 individuos control eran hombres. La edad media en los grupos fue de 54±8 años y los valores del IMC fueron indicativos de sobrepeso. La ingesta de carbohidratos, ácidos grasos trans y sodio fue mayor en el grupo IC que en el grupo control (p=0,006, p.

  6. [How to prescribe for patients with dysphagia: a review for the adaptation of the pharmaceutical guide in a socio-sanitary hospital].

    PubMed

    Hernández Martín, J; Correa Ballester, M; Vial Escolano, R; Forcano García, M; Gómez Navarro, R; González García, P

    2013-01-01

    Objetivo: Revisar la guía farmacoterapéutica del hospital para incluir formas farmacéuticas adaptadas a pacientes con disfagia y recomendaciones para la administración de medicamentos en estos pacientes. Método: Se realizó una búsqueda bibliográfica para elaborar las recomendaciones generales de administración de medicamentos en disfagia. Se comprobó para cada principio activo: a) si existían comercializadas otras formas farmacéuticas más recomendables; b) si había posibilidad de manipular los comprimidos o cápsulas, y c) si eran compatibles con alimentos. Resultados: Se desarrolló un algoritmo de decisión para ayudar en la selección de la forma farmacéutica y de su método de administración. Se incluyó un apartado de recomendaciones de administración para cada principio activo. La búsqueda supuso la inclusión de once formas bucodispersables, veintiséis líquidas y ocho como polvo. Conclusiones: La revisión mejorará la utilidad de la guía como instrumento para la prescripción, validación y administración de medicamentos en disfagia.

  7. Chia induces clinically discrete weight loss and improves lipid profile only in altered previous values.

    PubMed

    Tavares Toscano, Luciana; Tavares Toscano, Lydiane; Leite Tavares, Renata; da Oliveira Silva, Cássia Surama; Silva, Alexandre Sérgio

    2014-12-14

    Introducción: Debido al alto contenido de fibra dietética, la chía (Salvia hispánica L.) han sido propuesta para la pérdida de peso y mejora del perfil lipídico y glucémico. Pero los datos en humanos son escasos o inexistentes, en función de la variable analizada. Objetivo: Evaluar el efecto de la suplementación con harina de chía en la composición corporal, perfil lipídico y glucémico de individuos con sobrepeso y obesidad. Métodos: hombres y mujeres fueron asignados aleatoriamente en grupos que consumieron 35 g / día de chía (CHIA; n = 19; 48.8 ± 1.8 años) o placebo (PLA; n = 7; 51.4 ± 3.1 años) durante 12 semanas. La composición corporal y el consumo de alimentos fueron evaluados la cada cuatro semanas de intervención. Perfil lipídico y los niveles de glucosa se midieron al principio y al final del estudio. Resultados: La chía promovió reducción significativa en el peso corporal (-1.1kg; p.

  8. [Independent ethics committees for clinical research in Argentina. An evaluation and a system to guarantee their independence].

    PubMed

    Gonorazky, Sergio E

    2008-01-01

    The Administración Nacional de Medicamentos, Alimentos y Tecnología Médica de la República Argentina (ANMAT) requires that an independent ethics committee of sponsors and/or researchers must previously evaluate and approve all the new pharmacological research protocols carried out on human beings. However, due to the lucrative nature of the evaluation, and because the selection of the Independent Ethics Committee is carried out by the sponsors and/or researchers, the assumed autonomy of the former can be reduced to merely a relationship of "service provider-customer". The Institutional Review Board of the Mar del Plata s Community Hospital has evaluated, between 2005 and 2006, thirty three research protocols (with their corresponding information sheets for patients and informed consent forms) previously approved by a non-institutional Independent Ethics Committee. The median number of objections made by the Institutional Review Board, which prompted the previously mentioned protocols to be modified in order to be approved, was of three per protocol. In other words, the accreditation of an Independent Ethics Committee requires a system that guarantees actual independence from the sponsors and/or researchers, as well as management control mechanisms that may lead them into an eventual loss of accreditation. Several measures are proposed in order to correct the deficiencies of the present system. PMID:18499958

  9. Impact of a high-fat diet containing canola or soybean oil on body development and bone; parameters in adult male rats.

    PubMed

    Soares da Costa, Carlos Alberto; De Sousa dos Santos, Aline; Santana Carlos, Aluana; Lopes Gonzalez, Gabrielle de Paula; Pontes Gaspar Reis, Rejane; Carneiro, Cynthia; Soares Alves, Sanderson; Pereira Albuquerque, Karine; Alves da Silva, Paula Cristina; Cavalcante Ribeiro, Danielle; Teles Boaventura, Gilson; de Moura, Egberto Gaspar; Alves do Nascimento-Saba, Celly Cristina

    2015-05-01

    Introducción: El papel del ácido graso en la prevención o la progresión de las enfermedades crónicas ha generado un interés significativo por parte de los investigadores. Por lo tanto, nuestro objetivo fue evaluar los efectos a largo plazo de la dieta alta en grasas que contienen soja o aceite de canola en los parámetros de desarrollo del cuerpo y los huesos de ratas macho. Métodos: Después del destete, las ratas se agruparon y se alimentaron con una dieta control (7S) o una dieta alta en grasa que contiene soja (19S) o aceite de canola (19C). Fémur y vértebras lumbares (LV4) estructura se determinaron a los 180 días por absorciometría dual de rayos X y tomografía computarizada. Resultados: Los grupos mostraron similares ingesta de alimentos, la masa corporal y el desarrollo de longitud. Los parámetros óseos de la 19C fueron similares al grupo control, mientras que los 19S mostró parámetros óseos inferiores en comparación con los otros grupos. Conclusiones: La dieta alta en grasas que contiene aceite de soja fue desfavorable a la estructura ósea, mientras que el aceite de canola contribuyó salud de los huesos en la etapa adulta de la vida.

  10. Neotectonic and paleoseismicity studies on the Urumaco Fault, northern Falcón Basin, northwestern Venezuela

    NASA Astrophysics Data System (ADS)

    Audemard, Franck A.; Bousquet, Jean-Claude; Rodríguez, José A.

    1999-07-01

    The northern Falcón Basin in northwestern Venezuela is affected by several small active faults, subordinated to the major right-lateral east-west-trending Oca-Ancón Fault System. A set of prominent NW-SE right-lateral faults — synthetic shears — such as the Urumaco, Rı´o Seco, Lagarto and La Soledad faults, stands out among those. The Urumaco Fault, located between the Lagarto and Mitare rivers (in the Urumaco Trough, west of Coro), presents a rather complex active fault trace that comprises two NW-SE fault segments linked by an ENE-WSW reverse echelon, all showing a restraining stepover geometry. Its western segment seems to continue to the north at sea. Conversely, the eastern one dies out on land and its northern tip ends in a transtensive horse-tail structure, that disrupts an Early Pleistocene conglomerate. This same unit is flexed and upheaved some 30 m at the restraining overlap. The kinematics and present stress tensor, the latest activity and the seismogenic potential of the eastern segment of the Urumaco Fault, have been assessed at a set of three river cuts of an ephemeral tributary stream of the Urumaco River, 3 km north of the Urumaco village, where the Urumaco Formation is truncated by a Late Pleistocene terrace ( 14C date of 20,700±950 yr BP at the base) of the Urumaco River. On the one hand, one of these outcrops features the Urumaco Fault affecting the Late Miocene Urumaco Formation, which comprises two prominent fault planes disposed as a wedge. The southwestern bounding plane juxtaposes two different sequences whereas the northeastern one does not, implying different slip behavior. In fact, the northeastern plane shows oblique-slip striations (29°N, normal-dextral), whereas the other one shows perfectly horizontal striations (right-lateral). On the other hand, both updip plane prolongations in the overlying alluvial unit are not so sharp, if the 17-cm throw of the erosive bottom of such terrace measured at the lowermost part of the

  11. Identification of Calderas Associated With The Acidic Jurassic Volcanism of Southern Patagonia, Argentina

    NASA Astrophysics Data System (ADS)

    Chernicoff, C. J.; Salani, F. M.

    During the Jurassic, the Patagonian region was subject to a predominantly acidic volcanism locally known as the Chon Aike Volcanic Province, related to the breakup of Gondwana. It comprises ignimbrites, breccias and agglomerates, and a minor component of rhyolitic and dacitic lava domes. In the study area (Río Seco region, Santa Cruz Province), the Jurassic volcanics are largely overlain by Neogene and Quaternary sediments. However, the aeromagnetic survey of this region has unravelled the magnetic pattern of the volcanics, notably two conspicuous calderas, since the young cover sediments are non-magnetic. The magnetic susceptibility of the volcanic rocks ranges 50 to 80 x 10-5 S.I., as oppossed to the nearly null values of the overlying sediments. The geological interpretation of the aeromagnetic survey is mostly based on the analytic signal of the total magnetic intensity, where two distinct sub-circular magnetic lineaments have been recognized and regarded as calderic structures. The eastern caldera, 30 km wide, is centered at 48º 52' S.L./ 68º 02' W.L., and the western caldera, 23 km wide, is centered at 48º 53' S.L. / 68º 29' W.L.. In addition, a number of smaller, high gradient magnetic anomalies have been identified and interpreted as intra- and extracaldera domes. In the eastern caldera, a number of domes follow an anular pattern of fractures regarded as the boundary of an older, outer caldera. A magnetic circular lineament located within the latter structure has been interpreted as a younger, inner caldera which presents a number of small domes in its central depression; additional domes are also located in between the two calderic structures. The western caldera is less complex since it comprises a single structure with intra-caldera domes. The total magnetic gradient (analytic signal) associated with the domes is one order of magnitude higher (0.1 to 0.2) than the mean value of the region (0.03). In addition to the anular fractures and domes, a

  12. Remote sensing of plant emissions of volatile isoprenoids with PRI. Prospects for upscaling (Invited)

    NASA Astrophysics Data System (ADS)

    Penuelas, J.

    2013-12-01

    Josep Peñuelas*1,2, Giovanni Marino1,2,3,4, Joan LLusia1,2, Catherine Morfopoulos1,2,5, Gerard Farre-Armengol1,2, Shawn Kefauver, Alex Guenther6 , Francesca Rapparini7 , Roger Seco1,2,6, Marc Estiarte1,2, Mónica Mejia-Chang1,2, Romà Ogaya1,2, Jordi Sardans1,2 , Andrew Turnipseed6, Peter Harley6, Osvaldo Facini7, Rita Baraldi7, Jim Greenberg6 , Iolanda Filella1,2 1 CSIC, Global Ecology Unit CREAF-CEAB-UAB, Cerdanyola del Vallés 08193, Catalonia, Spain 2 CREAF, Cerdanyola del Vallés 08193, Catalonia, Spain 3 Dipartimento di Bioscienze e Territorio, Università degli Studi del Molise, Contrada Fonte Lappone, 86090 Pesche (IS), Italy 4 Institute for Plant Protection, National Research Council, Via Madonna del Piano 10, 50019 Sesto Fiorentino (FI), Italy 5 Division of Ecology and Evolution, Imperial College, Silwood Park, Ascot, SL5 7PY, UK 6 Atmospheric Chemistry Division, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000, USA 7 Biometeorology Institute, IBIMET-CNR, Via P. Gobetti 101, Bologna, Italy Abstract Terrestrial plants re-emit around 1-2% of the carbon they fix as isoprene and monoterpenes. These emissions play major roles in the ecological relationships among living organisms and in atmospheric chemistry and climate, and yet their actual quantification at the ecosystem level in different regions is far from being resolved. Phenomenological models are used to estimate the emission rates, but the limited understanding of the function and regulation of these emissions leads to large uncertainties in such estimations. Many measurements have been made at the foliar but few at the ecosystem level, and those that do exist are limited in space and time. We here provide evidence that a simple remote sensing index, the photochemical reflectance index (PRI), which is indicative of light use efficiency (LUE), is a good indirect estimator of foliar isoprenoid emissions and therefore can be used to sense them remotely. These results open

  13. Use of vitamin D in clinical practice.

    PubMed

    Cannell, John J; Hollis, Bruce W

    2008-03-01

    The recent discovery--from a meta-analysis of 18 randomized controlled trials--that supplemental cholecalciferol (vitamin D) significantly reduces all-cause mortality emphasizes the medical, ethical, and legal implications of promptly diagnosing and adequately treating vitamin D deficiency. Not only are such deficiencies common, and probably the rule, vitamin D deficiency is implicated in most of the diseases of civilization. Vitamin D's final metabolic product is a potent, pleiotropic, repair and maintenance, seco-steroid hormone that targets more than 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. One of the most important genes vitamin D up-regulates is for cathelicidin, a naturally occurring broad-spectrum antibiotic. Natural vitamin D levels, those found in humans living in a sun-rich environment, are between 40-70 ng per ml, levels obtained by few modern humans. Assessing serum 25-hydroxy-vitamin D (25(OH)D) is the only way to make the diagnosis and to assure treatment is adequate and safe. Three treatment modalities exist for vitamin D deficiency: sunlight, artificial ultraviolet B (UVB) radiation, and vitamin D3 supplementation. Treatment of vitamin D deficiency in otherwise healthy patients with 2,000-7,000 IU vitamin D per day should be sufficient to maintain year-round 25(OH)D levels between 40-70 ng per mL. In those with serious illnesses associated with vitamin D deficiency, such as cancer, heart disease, multiple sclerosis, diabetes, autism, and a host of other illnesses, doses should be sufficient to maintain year-round 25(OH)D levels between 55 -70 ng per mL. Vitamin D-deficient patients with serious illness should not only be supplemented more aggressively than the well, they should have more frequent monitoring of serum 25(OH)D and serum calcium. Vitamin D should always be adjuvant treatment in patients with serious illnesses and never replace standard treatment. Theoretically

  14. Molecular structure of the chicken vitamin D-induced calbindin-D28K gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements.

    PubMed

    Minghetti, P P; Cancela, L; Fujisawa, Y; Theofan, G; Norman, A W

    1988-04-01

    The seco-steroid hormone 1,25-dihydroxyvitamin D3 is known to induce the expression of a calcium binding protein termed calbindin-D28K in a variety of target tissues. In order to comprehend the mechanism of induction we have cloned and sequenced the chicken calbindin-D28K gene. The gene spans some 18.5 kilobases (kb) of chromosomal DNA from the putative Cap site to the polyadenylation site of the 2.8 kb mRNA. It is split into 11 coding exons by 10 intervening sequences. The promoter region of this gene is markedly G + C-rich (60-80%) extending from -225 to +400. Within this region we find 70 CpG dinucleotides, four G-C boxes, and numerous known promoter regulatory signals. These putative regulatory signals include a TATA box (ATAAATA) at -30 and a CAT box (CCAAT) at -326. Ten additional variant CAT boxes are found in the upstream promoter region (-218 to -770) of this gene. Furthermore we have identified a glucocorticoid-like responsive element at -410 (TCTACACACTGTTCC) and this element overlaps a metal responsive element (TGCACTC) and a variant CAT box (CCAAAT) and juxtaposes an enhancer-like core element (AAATGGT) on its 3'-side. In addition, the calbindin-D28K promoter is composed of a variety of simple repeated sequences, some of which are components of putative regulatory signals. All splice junctions were found to conform to the GT-AG rule. A consensus sequence of the 5'-splice junction reads AG/GTAAG-TTATA. A consensus sequence of the 3'-splice site consists of two elements: a pyrimidine track (mainly T) followed by ACAG/G-T. A two-dimensional model of calbindin-D28K was constructed which projects the existence of 6 alpha-helix-loop-alpha-helix regions characteristic of calcium binding domains. The 3'-end of the gene consists of a single large (2039 base pair) uninterrupted exon, an organizational feature common to other members of the calcium binding protein gene family which include calmodulin, parvalbumin, Spec I, myosin light chains, etc. Another feature

  15. 1,25-Dihydroxyvitamin D3-mediated vesicular transport of calcium in intestine: time-course studies

    SciTech Connect

    Nemere, I.; Norman, A.W.

    1988-06-01

    Previous work has biochemically identified lysosomes containing calcium and calbindin-D28K (CaBP) in chick intestine that are sensitive to 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) status. In the present work, lysosomal accumulation of 45Ca was optimal after 30 min of absorption from in situ ligated duodenal loops. The areas under the curves, defined as lysosomal fractions in Percoll gradients, were calculated, and values after 10, 20, 30, and 40 min of transport were (+D/-D ratio) 0.90, 1.62, 1.88, and 1.78, respectively. Lysosomal CaBP also increased in parallel with the time of absorption and was not due to nonspecific adsorption. When lysosomal 45Ca was determined 2.5, 5, 10, 15, and 43 h after administration of 1.3 nmol 1,25-(OH)2D3 or vehicle, the area ratios were 1.02, 1.47, 3.10, 1.88, and 1.29, respectively. Analyses of serum 45Ca in the same birds yielded a closely parallel time course with 1,25-(OH)2D3-dependent intestinal calcium absorption; values were 108 +/- 12% (+/- SE), 164 +/- 29%, 300 +/- 35%, 340 +/- 39%, and 169 +/- 8% of vitamin D-deficient control values at 2.5, 5, 10, 15, and 43 h, respectively. Immunoreactive CaBP in lysosomal fractions did not change significantly between 5-43 h after administration of seco-steroid. A similar series of experiments was conducted with microsomal membranes containing putative endocytic vesicles, which are believed to deliver calcium to the lysosomes. The brush border origin of the vesicles was supported by the internalization of anti-CaBP immunoglobulin G after 3 min of absorption. Accumulation of 45Ca by endocytic vesicles was subsequently found to be maximal after 20 min of absorption (+D/-D = 1.48), declining again at 30 min (+D/-D = 1.16), while CaBP levels in the same fractions remained unchanged between 0-30 min of absorption.

  16. 1α,25(OH)2-3-Epi-Vitamin D3, a Natural Physiological Metabolite of Vitamin D3: Its Synthesis, Biological Activity and Crystal Structure with Its Receptor

    PubMed Central

    Molnár, Ferdinand; Sigüeiro, Rita; Sato, Yoshiteru; Araujo, Clarisse; Schuster, Inge; Antony, Pierre; Peluso, Jean; Muller, Christian; Mouriño, Antonio; Moras, Dino; Rochel, Natacha

    2011-01-01

    Background The 1α,25-dihydroxy-3-epi-vitamin-D3 (1α,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcription regulator. In vivo action of 1α,25(OH)2-3-epi-D3 is tissue-specific and exhibits lowest calcemic effect compared to that induced by 1α,25(OH)2D3. To further unveil the structural mechanism and structure-activity relationships of 1α,25(OH)2-3-epi-D3 and its receptor complex, we characterized some of its in vitro biological properties and solved its crystal structure complexed with human VDR ligand-binding domain (LBD). Methodology/Principal Findings In the present study, we report the more effective synthesis with fewer steps that provides higher yield of the 3-epimer of the 1α,25(OH)2D3. We solved the crystal structure of its complex with the human VDR-LBD and found that this natural metabolite displays specific adaptation of the ligand-binding pocket, as the 3-epimer maintains the number of hydrogen bonds by an alternative water-mediated interaction to compensate the abolished interaction with Ser278. In addition, the biological activity of the 1α,25(OH)2-3-epi-D3 in primary human keratinocytes and biochemical properties are comparable to 1α,25(OH)2D3. Conclusions/Significance The physiological role of this pathway as the specific biological action of the 3-epimer remains unclear. However, its high metabolic stability together with its significant biologic activity makes this natural metabolite an interesting ligand for clinical applications. Our new findings contribute to a better understanding at molecular level how natural metabolites of 1α,25(OH)2D3 lead to significant activity in biological systems and we conclude that the C3-epimerization pathway produces an active metabolite with similar biochemical and biological properties to those of the 1α,25(OH)2D3. PMID:21483824

  17. Phanerozoic atmosphere oxygen cycles revealed by trace elements in marine pyrite

    NASA Astrophysics Data System (ADS)

    Large, R. R.; Halpin, J.

    2014-12-01

    It is generally accepted that oxygen in the atmosphere rose in two major steps at around 2.4-2.2 and 0.7-0.5 billion years ago. The variation in atmosphere oxygen over the last 500 million years, is considered to have been relatively minor by comparison. Sedimentary pyrite from marine shales efficiently captures many trace elements from the oceans, providing a novel proxy for seawater chemistry. Here we use temporal changes in the selenium and cobalt content of Phanerozoic marine pyrite, coupled with the 87Sr/86Sr ratio in marine carbonate, to argue for five dramatic pO2 cycles, each starting with a period of oxygenation, followed by a period of de-oxygenation. The selenium proxy is based on the premise that increased erosion of continental rocks leads to the release of selenium as both the selenate and selenite species. Under neutral to alkaline, oxygenated conditions the selenate species remains highly soluble, where it can be readily transported via river systems to the ocean. Cobalt on the other hand becomes less soluble under increasing pO2 as the oxidized species Co2+ and CoO are immobilised by Fe and Mn oxyhydroxides, that form during weathering. Thus variations in the Se and Co composition of marine pyrite enable us to propose a new oxygenation proxy; the ratio Se/Co, which increases in marine pyrite during periods of increasing pO2 (oxygenation) and decreases during periods of decreasing pO2 (deoxygenation). The first half of each of the five Phanerozoic pO2 cycles involves an increase in atmosphere/ocean oxygenation driven initially by supercontinent dispersal, increased continental erosion and nutrient trace element flux to the oceans. Increased marine productivity leads to carbon and sulphur sequestration, producing metalliferous black shales, and further drives oxygenation to the peak of the cycle. The cycle downside suggests decreasing oxidative erosion and nutrient delivery, resulting in a drop in productivity. Continued drawdown of ocean trace

  18. Seasonal frost conditions and permafrost regime distribution in the high lands of Sierra Nevada (Spain)

    NASA Astrophysics Data System (ADS)

    Oliva, Marc; Gómez-Ortiz, Antonio; Salvador-Franch, Ferran; Salvà-Catarineu, Montserrat; Palacios, David; Tanarro, Luis Miguel; Ramos, Miguel

    2016-04-01

    Sierra Nevada, Southern Spain (37°S, 3°W), is the massif including the southernmost permafrost remnants in Europe. Over the last decades the distribution of permafrost in this massif has been examined through a combined approach including geomorphological, geophysical and monitoring studies. The purpose of this communication is to summarize all the studies relating to soil thermal regime in the high lands of Sierra Nevada. A 114.5 m deep borehole was drilled in 2000 in the Veleta summit (3380 m) in order to monitor soil temperatures in the summits of the massif. No permafrost regime was detected, with average temperatures stabilizing at 20 m depth at 2 °C. Seasonal frost conditions were also detected in periglacial landforms such as solifluction lobes and sorted-circles. In the Rio Seco cirque the mean annual temperatures in a solifluction lobe located in a southern glacial cirque of the massif (3005 m) were 3.9 °C at 1 m depth between 2006 and 2012; in the north-exposed San Juan valley, soil temperatures in another solifluction landform (2864 m) were 3.9 °C at 1 m depth between 2003 and 2012. In a sorted-circle located in the high plateau of Cerro de los Machos (3297 m) soil temperatures recorded an average of 1.7 °C at 50 cm depth between 2003 and 2011. The only place where temperatures were permanently negative was inside of the only active rock glacier distributed in the Veleta cirque, on the northern slope of the Veleta peak. Here, the remnants of a small glacier that existed during the Little Ice Age (LIA) are still present in the form of buried ice and permafrost buried under the boulders of this rock glacier. Temperatures averaged 0.2 °C at 1 m depth between 2006 and 2013, with permanently negative temperatures below this level until, at least, 10 m depth. Consequently, seasonal frost is widespread nowadays in most of the Sierra Nevada, with permafrost conditions strongly conditioned by the geomorphological setting and the recent environmental

  19. Create a Consortium and Develop Premium Carbon Products from Coal

    SciTech Connect

    Frank Rusinko; John Andresen; Jennifer E. Hill; Harold H. Schobert; Bruce G. Miller

    2006-01-01

    The objective of these projects was to investigate alternative technologies for non-fuel uses of coal. Special emphasis was placed on developing premium carbon products from coal-derived feedstocks. A total of 14 projects, which are the 2003 Research Projects, are reported herein. These projects were categorized into three overall objectives. They are: (1) To explore new applications for the use of anthracite in order to improve its marketability; (2) To effectively minimize environmental damage caused by mercury emissions, CO{sub 2} emissions, and coal impounds; and (3) To continue to increase our understanding of coal properties and establish coal usage in non-fuel industries. Research was completed in laboratories throughout the United States. Most research was performed on a bench-scale level with the intent of scaling up if preliminary tests proved successful. These projects resulted in many potential applications for coal-derived feedstocks. These include: (1) Use of anthracite as a sorbent to capture CO{sub 2} emissions; (2) Use of anthracite-based carbon as a catalyst; (3) Use of processed anthracite in carbon electrodes and carbon black; (4) Use of raw coal refuse for producing activated carbon; (5) Reusable PACs to recycle captured mercury; (6) Use of combustion and gasification chars to capture mercury from coal-fired power plants; (7) Development of a synthetic coal tar enamel; (8) Use of alternative binder pitches in aluminum anodes; (9) Use of Solvent Extracted Carbon Ore (SECO) to fuel a carbon fuel cell; (10) Production of a low cost coal-derived turbostratic carbon powder for structural applications; (11) Production of high-value carbon fibers and foams via the co-processing of a low-cost coal extract pitch with well-dispersed carbon nanotubes; (12) Use of carbon from fly ash as metallurgical carbon; (13) Production of bulk carbon fiber for concrete reinforcement; and (14) Characterizing coal solvent extraction processes. Although some of the

  20. Bigger eyes in a wider universe: The American understanding of Earth in outer space, 1893--1941

    NASA Astrophysics Data System (ADS)

    Prosser, Jodicus Wayne

    Between 1893 and 1941, the understanding of the Milky Way galaxy within the American culture changed from a sphere to a spiral and Earth's location within it changed from the center to the periphery. These changes were based primarily upon scientific theories developed at Mount Wilson Observatory near Pasadena, California. This dissertation is an "astrosophy" that traces the history of changing depictions of the Milky Way in selected published sources and identifies key individuals, theories and technologies involved. It also demonstrates why the accepted depictions of the universe envisioned at Mount Wilson were cultural-scientific products created, in part, as the result of place. Southern California became the hearth of a culture that justified its superiority based upon its unique climate. Clear skies, remarkable visibility, and a perceived existence of intense natural light became the basis for the promotion of Mount Wilson as the premier location for astronomical observations. Conservation, en plein air paintings, and the concept of pays age moralisé are Southern Californian cultural products of the early 1900s that promoted an idealized society capable of exceptional intellectual endeavors and scientific accomplishments. The efforts of astronomers Hale, Shapley, Adams, Hubble and Ritchey resulted in the changing American understanding of the universe. This dissertation reveals how the diverse social interactions of these astronomers intersected Arroyo Seco meetings, women's organizations, the Valley Hunt Club elites, and philanthropic groups that comprised the schizophrenic culture of Pasadena. Their astronomical theories are compared to other aspects of the Southern Californian culture revealed in the writings of Raymond Chandler, Nathanael West and John Fante. The desire of astronomers to gain prestige from their discoveries is compared to competition in the creative processes of Hollywood. The theories created by astronomers and the films of the motion

  1. Mechanisms of the S/CO/Se interchange reactions at FeMo-co, the active site cluster of nitrogenase.

    PubMed

    Dance, Ian

    2016-09-28

    The active site of the N2 fixing enzyme nitrogenase is a C-centred Fe7MoS cluster (FeMo-co) containing a trigonal prism of six Fe atoms connected by a central belt of three doubly-bridging S atoms. The trigonal faces of the prism are capped via triply-bridging S atoms to Fe1 at one end and Mo at the other end. One of the central belt atoms, S2B, considered to be important in the chemical mechanism of the enzyme, has been shown by Spatzal, Rees et al. to undergo substitution by CO, and also substitution by Se in the presence of SeCN(-), under turnover conditions. Further, when turning over under C2H2 or N2/CO there is migration of Se to the other two belt bridging positions. These reactions are extraordinary, and unprecedented in metal chalcogenide cluster chemistry. Using density functional simulations, mechanisms for all of these reactions have been developed, involving the small molecules SCO, SeCO, C2H2S, C2H2Se, SeCN(-), SCN(-) functioning as carriers of S and Se atoms. The possibility that the S2B bridge position is vacant is discounted, because the barrier to formation of a bridge-void intermediate with two contiguous three-coordinate Fe atoms is too large. A bridging ligand is retained throughout the proposed mechanisms. Intermediates with Fe-C(O)-S/Se-Fe cycles and with SCO/SeCO C-bound to Fe are predicted. The energetics of the reaction trajectories show them to be feasible and easily reversible, consistent with experiment. Alternative mechanisms involving intramolecular differential rotatory rearrangements of the cluster to scramble the Se bridges are also examined, and shown to be very unlikely. The implications of these new facets of the reactivity of the FeMo-co cluster are discussed: it is considered that they are unlikely to be part of the mechanism of the physiological reactions of nitrogenase. PMID:27534727

  2. Was all that Los Angeles River flood control concrete necessary?

    NASA Astrophysics Data System (ADS)

    Patzert, W. C.; Regalado, S. S.; LaDochy, S.; Ramirez, P. C.; Willis, J. K.

    2014-12-01

    In 1938, heavy rains over the Los Angeles Basin resulted in widespread and costly flooding of the Los Angeles River floodplain. In response to the resultant damage, 51 miles of the River was concreted from the San Fernando Valley to the Pacific Ocean. Today proposals to modify the river to capture more water and to restore it to a more natural state have been approved. Through comparison of rainfall data, we test whether channelization can adequately handle the extreme flooding events occurring since 1938. Between February 27th to March 3rd 1938, two major storms resulted in 14.1 inches of rain in Pasadena, CA leading to the flooding of the Los Angeles River, 115 fatalities, the destruction of 5,601 buildings, and to $627 million (2011 dollars) in damages. Downtown Los Angeles averages 15 inches of precipitation a year, while the San Gabriel Mountains, where most of the Los Angeles River watershed rainfall is collected, typically receive more than 40 inches of rain annually. Eight record storms, each with rainfall totals over 11 inches, since the 1938 flood could have created devastating deluges were it not for channelization. Presently, at full stage the channelized Los Angeles River can accommodate a discharge of 129,000 cfs. During the 1938 flood event the discharge peaked at 68,000 cfs above Arroyo Seco and 79,000 cfs below Firestone Blvd. A similar storm event today would have led to increased discharge due to urbanization. Since 1938, the greatest discharge recorded at the same stations was 52,200 and 74,400 cfs during the February 16th 1980 storm. Although damage was substantial during this storm, river channelization prevented fatalities and much damage. To date, the channelization of the Los Angeles River has been successful in flood control. However, our research shows that southern California precipitation is becoming more intense which may result in increased flooding. Any future modifications to the river must be prepared to handle the extreme flooding

  3. Map and description of the active part of the Slumgullion Landslide, Hinsdale County, Colorado

    USGS Publications Warehouse

    Fleming, R.W.; Baum, Rex L.; Giardino, Marco

    1999-01-01

    This text accompanies a map of many of the features on the active part of the Slumgullion landslide, Hinsdale County, Colo. Long-term movement creates and destroys a variety of structural features on the surface of the landslide including faults, fractures, and folds, as well as basins and ridges. The Slumgullion landslide consists of a large volume of inactive landslide deposits and a much smaller volume that is actively moving within the deposits of the older landslide. Previously, collapse of the south side of the scarp on Mesa Seco produced materials that blocked the Lake Fork of the Gunnison River and created Lake San Cristobal. The current landslide activity was triggered by a collapse, which apparently extended the preexisting headscarp toward the north. The loading induced by the deposition of the collapsed materials reactivated some of the older landslide deposits. Displacement rates in the active part of the landslide range from about 0.2 m/yr at the uppermost fractures to a maximum of 7.4 m/yr in the narrowest part of the landslide. From this maximum rate, displacement rate declines to 2 or less m/yr at the toe. The interplay between different displacement rates, varying width, and curving boundaries gives rise to the structures within the landslide. For purposes of description, the landslide has been divided into seven zones: head, zone of stretching, the hopper and neck, zone of pull-apart basins, pond deposits and emergent toe, zone of shortening and spreading, and active toe. Each zone has its characteristic kinematic expression that provides information on the internal deformation of the landslide. In general, the upper part of the landslide is characterized by features such as normal faults and tension cracks associated with stretching. The lowermost part of the landslide is characterized by thrust faults and other features associated with shortening. In between, features are a result of widening, bending, or narrowing of the landslide. Also, in

  4. Incorporating multi-platform remote sensing products for prediction of post-fire hydrologic recovery

    NASA Astrophysics Data System (ADS)

    Kinoshita, A. M.; Hogue, T. S.; Kim, J.

    2011-12-01

    Wildfires are increasing in intensity and size across the western US, and more than half of the 20 largest fires in California have occurred within the last decade. Development in southern California has increased and as a result many homes at the wildland-urban interface (WUI) are affected by fire events themselves and post-fire processes. Current management efforts are mostly concentrated around immediate post-fire effects (first storm season); however, burned systems are often altered for prolonged periods of time, creating long-term concerns for downstream communities at the WUI. Previous work in two southern Californian watersheds, City Creek and Devil Canyon, shows lack of vegetation recovery and significant changes in annual and seasonal discharge for the post-fire study period (seven years). Applying remotely sensed data streams enhances monitoring of large and ungauged burned areas at high spatial and temporal resolutions. The goal of the current study is to integrate remote sensing data from multiple satellite platforms to improve prediction of the spatial and temporal variability of key hydrological variables controlling post-fire response. Remote sensing data streams from Moderate-resolution Imaging Spectroradiometer (MODIS) and Landsat are used to derive a range of land surface parameters and evaluate ecosystem and hydrologic recovery for the Arroyo Seco, an urban-fringe watershed in southern California burned by the 2009 Station Fire. A UCLA remotely-sensed evapotranspiration (ET) product is used to provide insight on vegetation growth and plant water availability. A UCLA MODIS-AMSR-E soil moisture product is used to evaluate the spatial variability of post-fire surface soil moisture and coupled storm runoff response. A range of other parameters, surface temperature, albedo and vegetation indices, are also evaluated to provide insight on the spatial variability of watershed recovery. Predicting the short and long-term risks of post-fire floods, debris

  5. The rain-triggered Atenquique volcaniclastic debris flow of October 16, 1955 at Nevado de Colima Volcano, Mexico

    NASA Astrophysics Data System (ADS)

    Saucedo, R.; Macías, J. L.; Sarocchi, D.; Bursik, M.; Rupp, B.

    2008-06-01

    On October 16, 1955, at 10:45 a.m. (local time), after three days of intense rain (140 mm) that was twice the monthly average precipitation, a devastating flood surge formed a volcaniclastic debris flow on the eastern slopes of Nevado de Colima Volcano. Nearly simultaneous flood surges formed in the Arroyo Seco, Los Platanos, and Dos Volcanes ravines that coalesced with the larger flow in the Atenquique ravine. At each confluence with a tributary, the flow was diluted. The texture and structure of the preserved 1955 deposits near high water marks indicate that the downstream flow was mainly in the lower range of debris flow concentration (60% sediment concentration by weight). Downstream the tributaries, the flood encountered a ˜ 0.06 × 10 6 m 3 water reservoir that failed, significantly increasing the surge volume. Additional entrained sediment also increased the flow volume. Downstream, the flood wave reached the town of Atenquique as an 8-9 m catastrophic wave causing the death of more than 23 people, the partial destruction of the town, and losses of ˜ 13,000,000 pesos (˜ 1 million US dollars today) to a paper mill and company facilities. According to eyewitness accounts the flood wave had a peak discharge that lasted ca. 10 to 15 minutes at Atenquique. Deposits at the site and the high-water marks observed from photographs of the town's church indicate that sediment concentration was ca. 60 wt.%. The flood continued for about 1 km to its junction with the Tuxpan River where it was diluted by mixing with normal flood flow. The deposits covered an area of ˜ 1.2 km 2 and had a minimum volume of ˜ 3.2 × 10 6 m 3. The main deposit consists of a single unit, averaging 4 m in thickness, with weak textural variations that suggest surging within the flood wave. The deposit is heterolithologic and consists of boulders set in a matrix of sand-size sediment, with polymodal or bimodal distributions and normal grading varying with distance from source. The town of

  6. Implementation of a nutrition education program in a handball team; consequences on nutritional status.

    PubMed

    Molina-López, Jorge; Molina, José Manuel; Chirosa, Luis Javier; Florea, Daniela; Sáez, Laura; Jiménez, Jorge; Planells, Paloma; Pérez de la Cruz, Antonio; Planells, Elena

    2013-01-01

    Objetivos: Evaluar el estado nutricional y los hábitos dietéticos en respuesta a la aplicación de un programa de educación nutricional en jugadores profesionales de balonmano. Sujetos y metodología: Estudio longitudinal realizado a una muestra de 14 jugadores pertenecientes a un equipo de balonmano de alto rendimiento, a los que se les evaluó mediante recordatorio de 72 horas, un cuestionario de frecuencia de consumo, medidas antropométricas a lo largo de 4 meses, y a los que se les aplicó un programa de educación nutricional al inicio del estudio. Los valores de ingesta y de frecuencia de consumo fueron comparados con las recomendaciones de macronutrientes existentes para deportistas y micronutrientes para población sana, respectivamente, y con la pirámide de alimentos para población sana española. Resultados: La ingesta de energía de los deportistas se situó por debajo de las recomendaciones a lo largo de todo el estudio. La ingesta de macronutrientes respecto a la energía ingerida, se situó por debajo de las recomendaciones para la ingesta de carbohidratos y por encima de las recomendaciones para la ingesta de grasa, mostrada en los resultados obtenidos de frecuencia de consumo de alimentos. La educación nutricional produjo un incremento significativo (p < 0,01) en la ingesta de energía y macronutrientes tras su aplicación. A pesar de ello, no se produjeron cambios significativos en la ingesta de macronutrientes y micronutrientes al ajustar por energía ingerida. Los niveles bioquímicos se encontraron dentro de los rangos de normalidad durante todo el estudio. Discusión: El desequilibrio en la ingesta de nutrientes presente en los jugadores de balonmano hace necesario realizar un ajuste nutricional completo para poder establecer recomendaciones específicas para este tipo de población. La aplicación de un programa de educación nutricional monitorizada de manera continuada mediante seguimiento en los deportistas, puede tener como

  7. [Nutritional content of foods offered and consumed in a Spanish university canteen].

    PubMed

    Fernández Torres, Ángela; Moreno-Rojas, Rafael; Cámara Martos, Fernando

    2014-09-12

    Objetivo: El primer objetivo de nuestro trabajo fue estudiar los hábitos alimentarios durante el almuerzo en la Universidad de Córdoba. En segundo término se trató de reducir el consumo energetico de colesterol y grasa en la dieta de dicho colectivo. Marco: El estudio se realiza entre los años 2010 al 2012 sobre la principal cantina en la que se sirve comida en esta Universidad, centrándonos en la toma de alimento del almuerzo, que es la principal toma alimentaria a lo largo del día, suponiendo entre el 35 y 40% del total de calorías ingeridas a lo largo del día. Muestras: Se han abordado un total de 9530 observaciones que corresponden cada una de ellas a la valoración nutricional de una toma de alimento (almuerzo completo) por estudiantes, profesorado y personal de servicios. Diseño: El estudio se desarrolló en 5 fases de intervención y una previa en la que no se intervino, esta última se utilizó para establecer las ingestas habituales alimentarias del colectivo. En cada fase se incremento la información nutricional suministrada a los usuarios de la cantina, para en la fase final, desarrollar también una modificación del precio de los menús servidos. Análisis: Las elecciones alimentarias que realizaban los universitarios de forma libre fueron transformadas en cantidad de nutrientes mediante la valoración nutricional previa de los platos, desarrollada por cálculo mediante la base de datos Nutriplato®. Esto permitió evaluar 29 nutrientes que a partir de los datos observados de los usuarios se transformaron en % de aporte a la RDA (de cada grupo de población) lo que produce una estandarización de los datos que permitió un estudio estadístico posterior, mediante el procedimiento GLM (SPSS v15) para evaluar el efecto de los diferentes factores contemplados. Principales medidas tomadas: Se tuvieron en cuenta como factores de clasificación (variables independientes): sexo, grupo de edad y nivel de grasa corporal, así como la fase de

  8. Compliance of nutritional recommendations of Spanish pregnant women according to sociodemographic and lifestyle characteristics: a cohort study.

    PubMed

    Villar-Vidal, María; Amiano, Pilar; Rodríguez-Bernal, Clara; Santa Marina, Loreto; Mozo, Imanol; Vioque, Jesús; Navarrete-Muñoz, Eva María; Romaguera, Dora; Valvi, Damaskini; Fernández Samoano, Ana; Tardón, Adonina; Ibarluzea, Jesús

    2015-04-01

    Objetivo: Estudiar las ingesta dietética y cumplimiento de las recomendaciones nutricionales de una población de mujeres embarazadas, de acuerdo a sus características sociodemográficas y hábitos de vida. Métodos: se trata de un estudio prospectivo basado en datos de la cohorte española INMA (Infancia y Medioambiente). Se han reclutado 2.585 mujeres embarazadas entre los años 2003 y 2008 en cuatro regiones diferentes de España. La ingesta dietética ha sido recogida mediante Cuestionarios de Frecuencia Alimentaria (CFA) y la información antropométrica, sociodemográfica y de estilos de vida a través de cuestionarios generales. La ingesta de grupos de alimentos y de vitaminas A, C y E y carotenoides fueron comparadas con las ingestas dietéticas de referencia de las guías Española y Americana. Resultados: El porcentaje de mujeres embarazadas que no cumplían las recomendaciones de cereales y legumbres (3-4 raciones /día) fue del 70 %, de frutas (2-3 raciones /día) el 39,2%, de verduras (2-4 raciones /día) fue del 47,3% y de lácteos (3-4 raciones /día) el 51,6%. La ingesta de frutas y verduras fue mayor en mujeres extranjeras y aumento con la edad, con el nivel de estudios y en mujeres con mayor actividad física (p.

  9. [Fructose consumption and its health implications; fructose malabsorption and nonalcoholic fatty liver disease].

    PubMed

    Riveros, María Jesús; Parada, Alejandra; Pettinelli, Paulina

    2014-03-01

    La ingesta de fructosa se ha incrementado considerablemente en los últimos años, especialmente bajo la forma de jarabe de maíz alto en fructosa, debido a su gran poder edulcorante. Diversos estudios, han asociado su elevado consumo con alteraciones metabólicas, hígado graso no alcohólico y malabsorción de fructosa, entre otras patologías. Esta revisión tiene como objetivo actualizar acerca del efecto de la alta ingesta de fructosa en el hígado e intestino, asociada principalmente a alimentos procesados con fructosa agregada. Métodos: Para la búsqueda bibliográfica se utilizaron las bases de datos de Pubmed, Scopus y Scielo, seleccionando aquellos artículos publicados después del año 2000 y resultantes de las palabras claves “fructose intake, high fructose corn syrup, nonalcoholic fatty liver and fructose, fructose malabsorption, fructose intolerance/metabolism”. Resultados: La búsqueda arrojó 735 publicaciones de las cuales 78 cumplieron con los criterios de inclusión. Conclusiones: El consumo de fructosa ha aumentado en las últimas décadas, especialmente a través de bebidas endulzadas y productos alimentarios con fructosa agregada. La alta ingesta de fructosa tiene un impacto a nivel intestinal y hepático, asociándose a patologías como hígado graso no alcohólico y malabsorción de fructosa.

  10. Prevalence of overweight and obesity among a university faculty and staffs from 2004 to 2010 in Wuhu, China.

    PubMed

    He, Lianping; Ren, Xiaohua; Qian, Yifan; Jin, Yuelong; Chen, Yan; Guo, Daoxia; Yao, Yingshui

    2014-05-01

    Antecedentes: El sobrepeso y la obesidad son epidemia en todo el mundo. El presente estudio fue examinar la prevalencia de sobrepeso y obesidad en una universidad, Facultad y personal utilizando dos referencias [Grupo de trabajo sobre la obesidad referencias en China (2004) y la Organización Mundial de la salud (OMS) criterios (2000)]. Objetivo: El objetivo de este estudio fue estimar la prevalencia del sobrepeso y la obesidad entre la facultad y personal de la Universidad en China. Métodos: Un estudio transversal fue diseñado para recoger los exámenes de salud de rutina los datos para una universidad la facultad y personal de 2004 a 2010 (2004, 2006, 2008 y 2010); los sujetos de 22-94 años. Resultados: Dependiendo de las referencias utilizadas (China y la OMS, respectivamente), la prevalencia de sobrepeso, incluyendo la obesidad de los sujetos fue un 36,1% y 25,5%, la prevalencia de obesidad fue del 5,3% y 1,5%, respectivamente, la prevalencia de sobrepeso, incluyendo la obesidad entre los sujetos varones, fue de 46% y 32,5%, respectivamente la prevalencia de sobrepeso, incluyendo la obesidad entre las mujeres fue de 21% y 14,1%, respectivamente, de una observación interesante es que la prevalencia global de sobrepeso aumentó con la edad. Conclusiones: Respecto a los daños del sobrepeso y la obesidad, es alentar la reducción de alimentos ambiente liberal y aumentar la actividad física entre universidad, Facultad y personal, especialmente para hombre facultad.

  11. [Nutritional analysis of dietary patterns in students of primary education with normal nutritional status].

    PubMed

    Durá-Gúrpide, Beatriz; Durá-Travé, Teodoro

    2014-06-01

    Objetivo: Realizar un análisis nutricional del modelo dietético en un grupo de alumnos de Educación Primaria (9-12 años) con estado nutricional normal. Material y Métodos: Registro de consumo de alimentos de dos días lectivos consecutivos en una muestra de 353 alumnos de Educación Primaria (188 varones y 165 mujeres) con una situación nutricional normal. Se ha calculado el consumo calórico y de macronutrientes, minerales y vitaminas comparándose con las ingestas recomendadas. Resultados: El valor medio del aporte calórico diario era de 2.066,9 kcal. Los cereales (33%), lácteos (19%) y carnes (17%) aportaban el 70% de la ingesta calórica total. Las proteínas aportaban el 20,3% de la ingesta calórica, los glúcidos el 48,8%, los lípidos el 30,9%, y las grasas saturadas el 12,6%. La ingesta de colesterol era excesiva y 2/3 de la ingesta proteica eran de origen animal. El valor medio de la ingesta de calcio, yodo y vitaminas A, D y E eran inferiores a los aportes dietéticos recomendados. Conclusiones: El modelo dietético de los alumnos de Educación Primaria con estado nutricional normal difiere del prototipo mediterráneo, con un consumo excesivo de carnes, limitado de cereales y lácteos, y deficiente en verduras y hortalizas, frutas, legumbres y pescados; dando lugar a un incremento del aporte de proteínas y grasas animales en detrimento de los hidratos de carbono complejos y un aporte deficiente de calcio, yodo y vitaminas A, D y E.

  12. [Not Available].

    PubMed

    Díaz, Toni; Ficapal-Cusí, Pilar; Aguilar-Martínez, Alicia

    2016-07-19

    Introducción: a pesar de la relevancia nutricional del desayuno para el desarrollo y su asociación a un mejor aprendizaje y rendimiento escolar, numerosos estudios ponen en evidencia que en muchos casos se omite o se hace mal.Objetivo: determinar la calidad del desayuno de estudiantes de entre 10 y 16 años con intención de determinar en qué momento sería conveniente realizar programas educativos sobre la importancia de esta comida y cómo mejorar su calidad.Método: estudio observacional, descriptivo y transversal a partir de un cuestionario con preguntas cerradas acerca de los hábitos de alimentación en el desayuno en estudiantes de educación primaria y secundaria.Resultados y conclusión: solo el 18,5% de los estudiantes realiza un desayuno de buena calidad y su mala calidad va aumentando progresivamente con los cursos y se asocia al hecho de desayunar solo. En ambos niveles educativos los alimentos más consumidos en casa pertenecen al grupo de los lácteos y los cereales, mientras que en el centro escolar, el bocadillo resulta el desayuno más habitual; no obstante se observan diferencias entre primaria y secundaria en cuanto al consumo de fruta y bebidas azucaradas, entre otros.Conclusión: sería interesante valorar la instauración de programas de desayuno escolar incluyendo en ellos no solo a estudiantes de primaria, sino también, y especialmente, a adolescentes pues son estos quienes omiten esta comida en mayor proporción. Las intervenciones deberían orientarse a corregir las desviaciones más habituales observadas en cada uno de los niveles educativos.

  13. EVOLUTION OF THE INTAKE AND NUTRITIONAL RECOMMENDATIONS OF CALCIUM AND VITAMIN D FOR THE LAST 14 YEARS IN SPAIN.

    PubMed

    Collado Yurrita, Luis; Grande Oyarzábal, Graciela; Garicano-Vilar, Elena; Ciudad Cabañas, María José; San Mauro Martín, Ismael

    2015-11-01

    Introducción: el calcio y la vitamina D son esenciales para el ser humano. La evidencia científica apoya la correlación entre ambos nutrientes y sus procesos esenciales en el correcto funcionamiento del organismo del ser humano, que es lo que justifica el aumento de la ingesta recomendada en España, desde 2001 hasta hoy en día. Objetivos: analizar la evolución en la ingesta del calcio y la vitamina D en relación con la evolución de las Ingestas Diarios Recomendadas, así como su repercusión, desde 2001 hasta hoy en día. Diseño: revisión bibliográfica en las principales bases de datos científicas, PubMed, SciELO y EMBASE. Se realizó una revisión centrada en la literatura científica sobre la vitamina D y el calcio, la evolución de su ingesta, cambios en las recomendaciones nutricionales y la importancia y las consecuencias de estos aspectos. Resultados: la ingestión real de calcio y vitamina D, durante este período de tiempo, ha disminuido en España, alcanzando valores medios de consumo por debajo recomendado. Conclusión: es posible que sea necesario aumentar el consumo de suplementos y alimentos fortificados, en algunos casos específicos, a fin de lograr la Ingesta Diaria Recomendada.

  14. Adherence to dietary recommendations among Spanish and immigrant adolescents living in Spain; the AFINOS study.

    PubMed

    Esteban-Gonzalo, Laura; Veiga, Oscar Luis; Gómez-Martínez, Sonia; Regidor, Enrique; Martínez, David; Marcos, Ascensión; Calle, María Elisa

    2013-11-01

    Objetivos: Este estudio compara la adherencia a las recomendaciones nutricionales de adolescentes inmigrantes y españoles residentes en la Comunidad de Madrid, España. Se comparó el consumo de ocho grupos principales de alimentos (verduras, frutas, pan/cereales, carne, huevos, pescado, legumbres, leche/derivados lácteos) incluyendo el consumo excesivo y deficiente de huevos, carne y pescado. También fue valorado el consumo excesivo de dulces y bebidas azucaradas. Posteriormente se analizó la influencia del tiempo de residencia en España sobre los mencionados hábitos de dieta. Material y método: Se llevó a cabo un estudio transversal en el que fueron recogidos datos auto-reportados durante el periodo comprendido entre Noviembre 2007 y Febrero 2008. Se obtuvo una muestra representativa de adolescentes con edades comprendidas entre 13 y 17 años (n=2081, 1055 mujeres) residentes en la Comunidad de Madrid. Los participantes pertenecían a centros de enseñanza secundaria seleccionados aleatoriamente según la distribución geográfica de los adolescentes en la región. Resultados: Los inmigrantes adolescentes presentaron una mayor probabilidad de no cumplir las recomendaciones nutricionales para el consume de carne, pescado, legumbres, pan/cereales y leche/derivados, de consumir una cantidad insuficiente de pescado y más dulces y bebidas azucaradas que sus compañeros españoles. Los adolescentes españoles mostraron una mayor probabilidad de no cumplir con la recomendación establecida para verduras. El tiempo de residencia afectó débilmente los hábitos de dieta, asociando aspectos tanto positivos como negativos. Conclusiones: La probabilidad de no cumplir las recomendaciones nutricionales fue mayor entre los adolescentes inmigrantes con excepción del consumo de frutas y verduras.

  15. [Not Available].

    PubMed

    Díaz, Toni; Ficapal-Cusí, Pilar; Aguilar-Martínez, Alicia

    2016-01-01

    Introducción: a pesar de la relevancia nutricional del desayuno para el desarrollo y su asociación a un mejor aprendizaje y rendimiento escolar, numerosos estudios ponen en evidencia que en muchos casos se omite o se hace mal.Objetivo: determinar la calidad del desayuno de estudiantes de entre 10 y 16 años con intención de determinar en qué momento sería conveniente realizar programas educativos sobre la importancia de esta comida y cómo mejorar su calidad.Método: estudio observacional, descriptivo y transversal a partir de un cuestionario con preguntas cerradas acerca de los hábitos de alimentación en el desayuno en estudiantes de educación primaria y secundaria.Resultados y conclusión: solo el 18,5% de los estudiantes realiza un desayuno de buena calidad y su mala calidad va aumentando progresivamente con los cursos y se asocia al hecho de desayunar solo. En ambos niveles educativos los alimentos más consumidos en casa pertenecen al grupo de los lácteos y los cereales, mientras que en el centro escolar, el bocadillo resulta el desayuno más habitual; no obstante se observan diferencias entre primaria y secundaria en cuanto al consumo de fruta y bebidas azucaradas, entre otros.Conclusión: sería interesante valorar la instauración de programas de desayuno escolar incluyendo en ellos no solo a estudiantes de primaria, sino también, y especialmente, a adolescentes pues son estos quienes omiten esta comida en mayor proporción. Las intervenciones deberían orientarse a corregir las desviaciones más habituales observadas en cada uno de los niveles educativos. PMID:27571666

  16. Egg consumption and risk of type 2 diabetes in a Mediterranean cohort; the sun project.

    PubMed

    Zazpe, Itziar; Beunza, Juan José; Bes-Rastrollo, Maira; Basterra-Gortari, Francisco Javier; Mari-Sanchis, Amelia; Martínez-González, Miguel Ángel

    2013-01-01

    Introducción y Objetivo: La prevalencia de la diabetes está aumentando a un ritmo alarmante en casi todos los países. Algunos estudios en poblaciones no mediterráneas sugieren que un mayor consumo de huevo se asocia con un mayor riesgo de diabetes. El objetivo de nuestro estudio fue evaluar prospectivamente la asociación entre el consumo de huevo y la incidencia de diabetes tipo 2 en una gran cohorte de graduados universitarios esp2013les. Métodos: Un total de 15.956 participantes (edad media: 38,5 2013s) seguidos durante 6,6 2013s (mediana), y libres de la diabetes mellitus al inicio del estudio fueron incluidos en este estudio. El consumo de huevos se evaluó al inicio del estudio a través de un cuestionario semicuantitativo de frecuencia de alimentos repetidamente validado en España. Los casos de diabetes mellitas incidente fueron diagnosticados por un médico a través de cuestionarios de seguimiento bianuales y posteriormente confirmados por los informes médicos o registros, de acuerdo con los criterios de la American Diabetes Association. Los análisis se realizaron a través de modelos de regresión logística no condicional multivariable. Resultados: Después de ajustar por los factores de confusión, el consumo de huevo no se asoció con el desarrollo de diabetes mellitus. Odds Ratio de aquellos participantes con mayores consumos frente a los del cuartel más bajo de consumo de huevos (< 4 huevos/semana frente a >1 huevo/semana) fue 0,7, IC del 95% CI 0.3-1.7. Conclusión: El consumo de huevos no se asoció con el desarrollo de diabetes mellitus en esta cohorte mediterránea.

  17. Protegiendo a su familia de los terremotos-Los siete pasos a la seguridad para prepararse en caso de un terremoto (en espa?ol y en ingles)

    USGS Publications Warehouse

    Desarrollado por American Red Cross, Asian Pacific Fund

    2007-01-01

    Les escribimos esta carta para comunicarle un mensaje sumamente importante sobre las preparaciones de emergencia. Historicamente, hemos sufrido terremotos aqui en el Area de la Bahia de San Francisco que han causado graves privaciones para los residentes de la comunidad y da?os increibles a nuestras ciudades. Es probable que suframos un terremoto de gran magnitud en los proximos 30 a?os. Muchos de nosotros venimos de otros paises donde hemos pasado por terremotos y por eso creemos entenderlos. Sin embargo, la manera que nos preparamos para terremotos en nuestros paises de origen puede ser distinta a la que empleamos aca en los Estados Unidos. Muy pocas personas mueren a causa de los derrumbes de los edificios en el Area de la Bahia porque la mayoria de los edificios son construidos para resistir el sacudimiento de la tierra. Pero es muy probable que su familia no tenga atencion medica, alimentos o que esten separados del uno al otro por dias o semanas. Finalmente depende de usted mantener a su familia a salvo hasta que llegue asistencia, por eso les pedimos que nos unamos para aprender a cuidar a su familia antes, durante, y despues de un terremoto. El primer paso es leer este libro. Cada uno de su familia, ni?os y adultos, pueden aprender como prepararse para un terremoto. Haga participar e incluya sus ni?os; pueden ayudarle a prepararse. Aproveche las clases ofrecidas en su comunidad sobre las preparaciones de terremotos por la Cruz Roja Estadounidense (American Red Cross). Estos cursos de preparacion son gratis y disponibles en espa?ol para todos en la comunidad sin tomar en cuenta la historia de la familia, estado legal, genero o edad. Les recomendamos que tome ventaja de estas clases gratuitas. Para mas informacion consulte la ultima pagina de este libro. Recuerde que un terremoto puede ocurrir sin aviso y la unica manera de reducir el da?o de terremotos es estar preparados. !Preparese!

  18. [NUTRITIONAL COMPONENTS AND MACULAR DEGENERATION AGE-RELATED].

    PubMed

    García-Montalvo, Iván Antonio; Matías-Pérez, Diana

    2015-04-28

    Objetivo: componentes nutricionales como los antioxidantes pueden modificar el riesgo de padecer Degeneración Macular Relacionada con la Edad (DMRE). Este es un artículo de revisión sistemática de estudios publicados relacionados con la modificación del estilo de vida, la nutrición y la ingesta de vitaminas para prevenir o retrasar la aparición o progresión de la DMRE. Resultados: el análisis de los resultados de investigación consultados pone de manifiesto que la DMRE es una de las causas de ceguera más frecuentes en sujetos mayores de 55 años. La DMRE se caracteriza por disminución de la visión, metamorfosias, macropsias, micropsias y escotoma central. Es una enfermedad que debe ser diagnosticada a tiempo, ya que puede conducir a la ceguera irreversible. Entre los componentes de la dieta que en numerosos estudios epidemiológicos han mostrado una asociación inversa con la DMRE y que se revisan en este trabajo se encuentran: vitaminas (E y C), minerales (ej. zinc, selenio, manganeso y cobre) y carotenoides. Conclusiones: existe una evidencia importante de que puede aplicarse un soporte nutricional a pacientes con DMRE. Esto requiere de la determinación de los beneficios nutricionales de estos nutrientes (vitaminas, minerales y carotenoides), o bien de alimentos nutracéuticos en pro de la salud de este grupo de enfermos.

  19. [Acceptance of handmade products containing nuts and fructooligosaccharides].

    PubMed

    de Freitas Folly, Gilce Andrezza; Neiva da Silva, Ester; Vieira Verner, Fabiana; Dos Santos Silva, Fernanda Cacilda; Pinheiro Volp, Ana Carolina

    2013-01-01

    Introducción: Los prebióticos y alimentos con propiedades funcionales proporcionan beneficios para la salud de los consumidores a través de la prevención de muchas enfermedades. Objetivo: Verificar la aceptación de productos artesanales (chocolate en barra, dulce de soja y pan dulce) formulados con nueces (linaza, maní y nueces de Brasil) y, o fructooligosacáridos (FOS). Métodos: Cuatro muestras de cada producto fueron preparados con adición de diferentes concentraciones de nueces y FOS. La evaluación sensorial se realizó mediante una muestra de 373 consumidores, con 126, 121 y 126 probadores para muestras de chocolate en barra, dulce de soja y pan dulce, respectivamente, utilizándose la escala hedónica de nueve puntos. Los resultados fueron sometidos a Análisis de Varianza (ANOVA) y el test de Tukey. Resultados y Discusión: Observándose las medias de los juzgamientos, se infiere que las muestras con mayor aceptación han sido de pan dulce con nueces de Brasil y, o FOS. Sin embargo, todas las muestras son buenas alternativas de mercado y se lo mostró un promedio de entre 6 y 9 puntos, más un aumento de ácidos grasos omega 3 y 6, proteínas, fibras, vitaminas, antioxidantes y minerales, así como fitoquímicos, los cuales desempeñan un papel importante en la promoción de la salud. Conclusión: Los productos artesanales formulados con oleaginosas y, o FOS tuvieron una buena aceptabilidad y pueden mejorar los hábitos alimentarios de los consumidores. Pero para probar la funcionalidad de estos productos, se necesitan nuevos estudios.

  20. [Not Available].

    PubMed

    Santaliestra-Pasías, Alba M; Bel-Serrat, Silvia; Moreno, Luis A; Bueno, Gloria

    2016-07-12

    Introducción: la elevada prevalencia de obesidad en niños es un problema de salud global y conlleva el desarrollo de comorbilidades asociadas, como hipertensión, dislipemia, inflamación crónica e hiperinsulinemia, que a su vez son reconocidos factores de riesgo cardiovascular. Algunos estudios han observado que el consumo de productos lácteos podría ejercer un papel protector sobre el desarrollo de enfermedades cardiovasculares; sin embargo, la evidencia científica es bastante limitada en niños y adolescentes.Objetivos: investigar la relación entre el consumo de productos lácteos y factores de riesgo cardiovascular en poblaciones jóvenes.Material y métodos: se ha revisado la literatura reciente, incluyendo adicionalmente datos procedentes del estudio HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence). Se incluyó una muestra de adolescentes (12,5-17,5 años) provenientes de 8 ciudades europeas.Resultados: datos estadounidenses muestran una disminución en la frecuencia de consumo de leche, así como en el tamaño de la porción consumida. En el estudio HELENA los productos lácteos fueron el grupo de alimentos que mejor identificó a los adolescentes con bajo riesgo cardiovascular. Además, un consumo elevado de leche y yogur, así como de bebidas a base de leche y yogur, se asoció con niveles más bajos de grasa corporal, menor riesgo cardiovascular y mayor condición física cardiorrespiratoria.Conclusiones: son necesarios más estudios para proporcionar evidencia y comprender mejor los mecanismos subyacentes de la asociación entre la ingesta de lácteos, especialmente el yogur, y la obesidad, la diabetes, y otros factores de riesgo cardiovascular.