20 CFR 633.105 - Allocation of funds.

Code of Federal Regulations, 2012 CFR

2012-04-01

... determined by the Department. The formula used to determine State allocations will be published in the Federal Register for review and comment, along with the rationale for such formula and proposed... adjustment. In situations where the Department determines that the formula allocation will result in severe...

26 CFR 1.401(a)(4)-2 - Nondiscrimination in amount of employer contributions under a defined contribution plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... greater of the allocations under two or more formulas, one of which is a top-heavy formula, the top-heavy... is the greater of the allocations under two or more formulas, and one or more of those formulas is... provide uniform allocations are permitted to satisfy this requirement by meeting one of the safe harbors...

26 CFR 1.401(a)(4)-2 - Nondiscrimination in amount of employer contributions under a defined contribution plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... greater of the allocations under two or more formulas, one of which is a top-heavy formula, the top-heavy... is the greater of the allocations under two or more formulas, and one or more of those formulas is... provide uniform allocations are permitted to satisfy this requirement by meeting one of the safe harbors...

20 CFR 667.130 - How are WIA title I formula funds allocated to local workforce investment areas?

Code of Federal Regulations, 2011 CFR

2011-04-01

... INVESTMENT ACT Funding § 667.130 How are WIA title I formula funds allocated to local workforce investment... Governor must reserve funds from each of these sources for Statewide workforce investment activities. In... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false How are WIA title I formula funds allocated...

45 CFR 400.319 - Allocation of funds.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Assistance Funding and Service Priorities § 400.319 Allocation of funds. (a) A State with more than one qualifying targeted assistance county may allocate its targeted assistance funds differently from the formula... population data in its allocation formula. (b) A State must assure that not less than 95 percent of the total...

45 CFR 400.319 - Allocation of funds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Assistance Funding and Service Priorities § 400.319 Allocation of funds. (a) A State with more than one qualifying targeted assistance county may allocate its targeted assistance funds differently from the formula... population data in its allocation formula. (b) A State must assure that not less than 95 percent of the total...

45 CFR 400.319 - Allocation of funds.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Funding and Service Priorities § 400.319 Allocation of funds. (a) A State with more than one qualifying targeted assistance county may allocate its targeted assistance funds differently from the formula... population data in its allocation formula. (b) A State must assure that not less than 95 percent of the total...

45 CFR 400.319 - Allocation of funds.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Funding and Service Priorities § 400.319 Allocation of funds. (a) A State with more than one qualifying targeted assistance county may allocate its targeted assistance funds differently from the formula... population data in its allocation formula. (b) A State must assure that not less than 95 percent of the total...

7 CFR 22.205 - Allocation of loan and grant funds.

Code of Federal Regulations, 2012 CFR

2012-01-01

... approved loan funding levels will be allocated among States by a formula designed to ensure equitable... allocations may be shifted from one State to another so as to enable the obligation of all available funds prior to the end of the fiscal year. (c) The formula used for fund allocation will ensure that a minimum...

7 CFR 22.205 - Allocation of loan and grant funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... approved loan funding levels will be allocated among States by a formula designed to ensure equitable... allocations may be shifted from one State to another so as to enable the obligation of all available funds prior to the end of the fiscal year. (c) The formula used for fund allocation will ensure that a minimum...

7 CFR 22.205 - Allocation of loan and grant funds.

Code of Federal Regulations, 2014 CFR

2014-01-01

... approved loan funding levels will be allocated among States by a formula designed to ensure equitable... allocations may be shifted from one State to another so as to enable the obligation of all available funds prior to the end of the fiscal year. (c) The formula used for fund allocation will ensure that a minimum...

7 CFR 22.205 - Allocation of loan and grant funds.

Code of Federal Regulations, 2013 CFR

2013-01-01

... approved loan funding levels will be allocated among States by a formula designed to ensure equitable... allocations may be shifted from one State to another so as to enable the obligation of all available funds prior to the end of the fiscal year. (c) The formula used for fund allocation will ensure that a minimum...

7 CFR 1940.552 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REGULATIONS (CONTINUED) GENERAL Methodology and Formulas for Allocation of Loan and Grant Program Funds § 1940..., funds will be controlled by the National Office. (b) Basic formula criteria, data source and weight. Basic formulas are used to calculate a basic state factor as a part of the methodology for allocating...

7 CFR 1940.552 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... REGULATIONS (CONTINUED) GENERAL Methodology and Formulas for Allocation of Loan and Grant Program Funds § 1940..., funds will be controlled by the National Office. (b) Basic formula criteria, data source and weight. Basic formulas are used to calculate a basic state factor as a part of the methodology for allocating...

7 CFR 1940.552 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... REGULATIONS (CONTINUED) GENERAL Methodology and Formulas for Allocation of Loan and Grant Program Funds § 1940..., funds will be controlled by the National Office. (b) Basic formula criteria, data source and weight. Basic formulas are used to calculate a basic state factor as a part of the methodology for allocating...

7 CFR 1940.552 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... REGULATIONS (CONTINUED) GENERAL Methodology and Formulas for Allocation of Loan and Grant Program Funds § 1940..., funds will be controlled by the National Office. (b) Basic formula criteria, data source and weight. Basic formulas are used to calculate a basic state factor as a part of the methodology for allocating...

7 CFR 1780.18 - Allocation of program funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... formulas by which the Administrator of the RUS allocates program funds to the States. (The term “State... possession of the United States, or the Western Pacific Areas.) (2) The formulas in this part are used to... Agency can be carried out. Considerations used when developing the formulas include enabling legislation...

7 CFR 1780.18 - Allocation of program funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... formulas by which the Administrator of the RUS allocates program funds to the States. (The term “State... possession of the United States, or the Western Pacific Areas.) (2) The formulas in this part are used to... Agency can be carried out. Considerations used when developing the formulas include enabling legislation...

7 CFR 1780.18 - Allocation of program funds.

Code of Federal Regulations, 2014 CFR

2014-01-01

... formulas by which the Administrator of the RUS allocates program funds to the States. (The term “State... possession of the United States, or the Western Pacific Areas.) (2) The formulas in this part are used to... Agency can be carried out. Considerations used when developing the formulas include enabling legislation...

7 CFR 1780.18 - Allocation of program funds.

Code of Federal Regulations, 2012 CFR

2012-01-01

... formulas by which the Administrator of the RUS allocates program funds to the States. (The term “State... possession of the United States, or the Western Pacific Areas.) (2) The formulas in this part are used to... Agency can be carried out. Considerations used when developing the formulas include enabling legislation...

7 CFR 1780.18 - Allocation of program funds.

Code of Federal Regulations, 2013 CFR

2013-01-01

... formulas by which the Administrator of the RUS allocates program funds to the States. (The term “State... possession of the United States, or the Western Pacific Areas.) (2) The formulas in this part are used to... Agency can be carried out. Considerations used when developing the formulas include enabling legislation...

LOTUS 1-2-3 and Decision Support: Allocating the Monograph Budget.

ERIC Educational Resources Information Center

Perry-Holmes, Claudia

1985-01-01

Describes the use of electronic spreadsheet software for library decision support systems using personal computers. Discussion covers templates, formulas for allocating the materials budget, LOTUS 1-2-3 and budget allocations, choosing a formula, the spreadsheet itself, graphing capabilities, and advantages and disadvantages of templates. Six…

Development of a Capital Allocations Formula.

ERIC Educational Resources Information Center

Thompson, I.; And Others.

A description is presented of the present state of development of a capital allocations formula for general building project costs at the University of Toronto. The first part of the paper is devoted to a discussion of the objectives and application of the formula in its present state. A detailed description of the available data and the…

24 CFR 968.103 - Allocation of funds under section 14.

Code of Federal Regulations, 2012 CFR

2012-04-01

... section is greater than one percent, the number of units on which formula funding is based will be the... there has been a one percent reduction in units on a cumulative basis; (ii) A reduction in formula... (c) of this section. (d) Formula allocation based on relative needs. After determining the amounts to...

Funding Allocation and Staff Management. A Portuguese Example

ERIC Educational Resources Information Center

Rosa, Maria Joao; Amado, Diana; Amaral, Alberto

2009-01-01

For many years the Portuguese Ministry of Education used a funding formula to allocate the State budget to public higher education institutions. Some of its major objectives were higher enrolments and allocation equity. As the expenditure on salaries was a major component of the budget, the formula was supposed to force convergence to established…

24 CFR 92.103 - Notification of intent to participate.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Not later than 30 days after receiving notice of its formula allocation amount, a jurisdiction must... local government that has a formula allocation of less than $750,000, or less than $500,000 in fiscal..., one or more of the following, as appropriate, as evidence that it has met the threshold allocation...

24 CFR 92.103 - Notification of intent to participate.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) Not later than 30 days after receiving notice of its formula allocation amount, a jurisdiction must... local government that has a formula allocation of less than $750,000, or less than $500,000 in fiscal..., one or more of the following, as appropriate, as evidence that it has met the threshold allocation...

24 CFR 92.103 - Notification of intent to participate.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Not later than 30 days after receiving notice of its formula allocation amount, a jurisdiction must... local government that has a formula allocation of less than $750,000, or less than $500,000 in fiscal..., one or more of the following, as appropriate, as evidence that it has met the threshold allocation...

24 CFR 92.107 - Revocation of designation as a participating jurisdiction.

Code of Federal Regulations, 2014 CFR

2014-04-01

... receive a formula allocation in any one year. (c) When HUD revokes a participating jurisdiction's... matching contribution requirements; or (b) The jurisdiction's formula allocation falls below $750,000 (or...

24 CFR 92.107 - Revocation of designation as a participating jurisdiction.

Code of Federal Regulations, 2013 CFR

2013-04-01

... receive a formula allocation in any one year. (c) When HUD revokes a participating jurisdiction's... matching contribution requirements; or (b) The jurisdiction's formula allocation falls below $750,000 (or...

24 CFR 92.107 - Revocation of designation as a participating jurisdiction.

Code of Federal Regulations, 2011 CFR

2011-04-01

... receive a formula allocation in any one year. (c) When HUD revokes a participating jurisdiction's... matching contribution requirements; or (b) The jurisdiction's formula allocation falls below $750,000 (or...

20 CFR 668.296 - How are WIA funds allocated to INA grantees?

Code of Federal Regulations, 2010 CFR

2010-04-01

... the following formula: (1) One-quarter of the funds available will be allocated on the basis of the...) The data and definitions used to implement these formulas is provided by the U.S. Bureau of the Census. (c) In years immediately following the use of new data in the formula described in paragraph (b) of...

Fiscal transfers based on inputs or outcomes? Lessons from the Twelfth and Thirteenth Finance Commission in India.

PubMed

Fan, Victoria Y; Iyer, Smriti; Kapur, Avani; Mahbub, Rifaiyat; Mukherjee, Anit

2018-01-01

There is limited empirical evidence about the efficacy of fiscal transfers for a specific purpose, including for health which represents an important source of funds for the delivery of public services especially in large populous countries such as India. To examine two distinct methodologies for allocating specific-purpose centre-to-state transfers, one using an input-based formula focused on equity and the other using an outcome-based formula focused on performance. We examine the Twelfth Finance Commission (12FC)'s use of Equalization Grants for Health (EGH) as an input-based formula and the Thirteenth Finance Commission (13FC)'s use of Incentive Grants for Health (IGH) as an outcome-based formula. We simulate and replicate the allocation of these two transfer methodologies and examine the consequences of these fiscal transfer mechanisms. The EGH placed conditions for releasing funds, but states varied in their ability to meet those conditions, and hence their allocations varied, eg, Madhya Pradesh received 100% and Odisha 67% of its expected allocation. Due to the design of the IGH formula, IGH allocations were unequally distributed and highly concentrated in 4 states (Manipur, Sikkim, Tamil Nadu, Nagaland), which received over half the national IGH allocation. The EGH had limited impact in achieving equalization, whereas the IGH rewards were concentrated in states which were already doing better. Greater transparency and accountability of centre-to-state allocations and specifically their methodologies are needed to ensure that allocation objectives are aligned to performance. © 2017 The Authors. The International Journal of Health Planning and Management published by John Wiley & Sons Ltd.

77 FR 52752 - Notice of FY 2012 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... allocations for Social Services are available on ORR's Web site at: http://www.acf.hhs.gov/programs/orr/policy...] Notice of FY 2012 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative Project... allocation of Refugee Social Services formula awards to States and Wilson/Fish Alternative Project grantees...

Investigation of rainfall and regional factors for maintenance cost allocation.

DOT National Transportation Integrated Search

2010-08-01

The existing formulas used by the Texas Department of Transportation (TxDOT) to allocate the statewide : maintenance budget rely heavily on inventory and pavement evaluation data. These formulas include : regional factors and rainfall indices that va...

Report on statistics for allocation of funds

DOT National Transportation Integrated Search

1978-03-01

This report examines the formulas used in allocating Federal funds to States and local areas. To understand the behavior of these formulas, one must understand the various aspects of the data, such as definitions, methods of collection, and methods o...

24 CFR 92.604 - ADDI allocation formula.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false ADDI allocation formula. 92.604 Section 92.604 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM American Dream Downpayment Initiative § 92.604 ADDI...

24 CFR 92.604 - ADDI allocation formula.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false ADDI allocation formula. 92.604 Section 92.604 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM American Dream Downpayment Initiative § 92.604 ADDI...

24 CFR 92.604 - ADDI allocation formula.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false ADDI allocation formula. 92.604 Section 92.604 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM American Dream Downpayment Initiative § 92.604 ADDI...

24 CFR 92.604 - ADDI allocation formula.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false ADDI allocation formula. 92.604 Section 92.604 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM American Dream Downpayment Initiative § 92.604 ADDI...

24 CFR 92.604 - ADDI allocation formula.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false ADDI allocation formula. 92.604 Section 92.604 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM American Dream Downpayment Initiative § 92.604 ADDI...

24 CFR 92.50 - Formula allocation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Formula allocation. 92.50 Section 92.50 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... previous fiscal year, are metropolitan cities, urban counties, or consortia approved under § 92.101; and...

Simple versus composite indicators of socioeconomic status in resource allocation formulae: the case of the district resource allocation formula in Malawi

PubMed Central

2010-01-01

Background The district resource allocation formula in Malawi was recently reviewed to include stunting as a proxy measure of socioeconomic status. In many countries where the concept of need has been incorporated in resource allocation, composite indicators of socioeconomic status have been used. In the Malawi case, it is important to ascertain whether there are differences between using single variable or composite indicators of socioeconomic status in allocations made to districts, holding all other factors in the resource allocation formula constant. Methods Principal components analysis was used to calculate asset indices for all districts from variables that capture living standards using data from the Malawi Multiple Indicator Cluster Survey 2006. These were normalized and used to weight district populations. District proportions of national population weighted by both the simple and composite indicators were then calculated for all districts and compared. District allocations were also calculated using the two approaches and compared. Results The two types of indicators are highly correlated, with a spearman rank correlation coefficient of 0.97 at the 1% level of significance. For 21 out of the 26 districts included in the study, proportions of national population weighted by the simple indicator are higher by an average of 0.6 percentage points. For the remaining 5 districts, district proportions of national population weighted by the composite indicator are higher by an average of 2 percentage points. Though the average percentage point differences are low and the actual allocations using both approaches highly correlated (ρ of 0.96), differences in actual allocations exceed 10% for 8 districts and have an average of 4.2% for the remaining 17. For 21 districts allocations based on the single variable indicator are higher. Conclusions Variations in district allocations made using either the simple or composite indicators of socioeconomic status are not statistically different to recommend one over the other. However, the single variable indicator is favourable for its ease of computation. PMID:20053274

Equity in health care in Namibia: developing a needs-based resource allocation formula using principal components analysis

PubMed Central

Zere, Eyob; Mandlhate, Custodia; Mbeeli, Thomas; Shangula, Kalumbi; Mutirua, Kauto; Kapenambili, William

2007-01-01

Background The pace of redressing inequities in the distribution of scarce health care resources in Namibia has been slow. This is due primarily to adherence to the historical incrementalist type of budgeting that has been used to allocate resources. Those regions with high levels of deprivation and relatively greater need for health care resources have been getting less than their fair share. To rectify this situation, which was inherited from the apartheid system, there is a need to develop a needs-based resource allocation mechanism. Methods Principal components analysis was employed to compute asset indices from asset based and health-related variables, using data from the Namibia demographic and health survey of 2000. The asset indices then formed the basis of proposals for regional weights for establishing a needs-based resource allocation formula. Results Comparing the current allocations of public sector health car resources with estimates using a needs based formula showed that regions with higher levels of need currently receive fewer resources than do regions with lower need. Conclusion To address the prevailing inequities in resource allocation, the Ministry of Health and Social Services should abandon the historical incrementalist method of budgeting/resource allocation and adopt a more appropriate allocation mechanism that incorporates measures of need for health care. PMID:17391533

Equity in health care in Namibia: developing a needs-based resource allocation formula using principal components analysis.

PubMed

Zere, Eyob; Mandlhate, Custodia; Mbeeli, Thomas; Shangula, Kalumbi; Mutirua, Kauto; Kapenambili, William

2007-03-29

The pace of redressing inequities in the distribution of scarce health care resources in Namibia has been slow. This is due primarily to adherence to the historical incrementalist type of budgeting that has been used to allocate resources. Those regions with high levels of deprivation and relatively greater need for health care resources have been getting less than their fair share. To rectify this situation, which was inherited from the apartheid system, there is a need to develop a needs-based resource allocation mechanism. Principal components analysis was employed to compute asset indices from asset based and health-related variables, using data from the Namibia demographic and health survey of 2000. The asset indices then formed the basis of proposals for regional weights for establishing a needs-based resource allocation formula. Comparing the current allocations of public sector health car resources with estimates using a needs based formula showed that regions with higher levels of need currently receive fewer resources than do regions with lower need. To address the prevailing inequities in resource allocation, the Ministry of Health and Social Services should abandon the historical incrementalist method of budgeting/resource allocation and adopt a more appropriate allocation mechanism that incorporates measures of need for health care.

Funding formulas for public health allocations: federal and state strategies.

PubMed

Ogden, Lydia L; Sellers, Katie; Sammartino, Cara; Buehler, James W; Bernet, Patrick M

2012-01-01

Public health funding formulas have received less scrutiny than those used in other government sectors, particularly health services and public health insurance. We surveyed states about their use of funding formulas for specific public health activities; sources of funding; formula attributes; formula development; and assessments of political and policy considerations. Results show that the use of funding formulas is positively correlated with the number of local health departments and with the percentage of public health funding provided by the federal government. States use a variety of allocative strategies but most commonly employ a "base-plus" distribution. Resulting distributions are more disproportionate than per capita or per-person-in-poverty allotments, an effect that increases as the proportion of total funding dedicated to equal minimum allotments increases.

Resource allocation and purchasing in the health sector: the English experience.

PubMed

Smith, Peter C

2008-11-01

The United Kingdom of Great Britain and Northern Ireland has extensive experience in allocating health service funds to regions and localities using funding formulae. This paper focuses on England. Special attention is given to recent policy concerns to reduce avoidable health inequalities by broadening the remit of the resource allocation formulae. The paper also examines the issues that arise when seeking to allocate funds to very small organizational units, such as general practices. The English example is relevant to less-developed health systems, especially for those governments seeking to decentralize, to improve accountability and to promote equity.

24 CFR 574.130 - Formula allocations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Formula allocations. 574.130... immunodeficiency syndrome used for this purpose shall be the number reported as of March 31 of the fiscal year... AIDS for the year, April 1 through March 31, preceding the fiscal year of the appropriation is higher...

Employing Needs-Based Funding Formulae--Some Unavoidable Tradeoffs

ERIC Educational Resources Information Center

Gilead, Tal; BenDavid-Hadar, Iris

2017-01-01

Purpose: The method by which the state allocates resources to its schooling system can serve as an important instrument for achieving desired improvements in levels of educational attainment, social equity and other social policy goals. In many school systems, the allocation of school resources is done according to a needs-based funding formula.…

Mental health community based funding: Ohio's experience in revising its funding allocation methodology.

PubMed

Seiber, Eric E; Sweeney, Helen Anne; Partridge, Jamie; Dembe, Allard E; Jones, Holly

2012-10-01

Over the past 20 years, states have increasingly moved away from centrally financed, state-operated facilities to financing models built around community-based service delivery mechanisms. This paper identifies four important broad factors to consider when developing a funding formula to allocate state funding for community mental health services to local boards in an equitable manner, based on local community need: (1) funding factors used by other states; (2) state specific legislative requirements; (3) data availability; and (4) local variation of factors in the funding formula. These considerations are illustrated with the recent experience of Ohio using available evidence and data sources to develop a new community-based allocation formula. We discuss opportunities for implementing changes in formula based mental health funding related to Medicaid expansions for low income adults scheduled to go into effect under the new Patient Protection and Affordable Care Act.

Grant Formulas. A Catalog of Federal Aid to States and Localities. Report to Congressional Committees.

ERIC Educational Resources Information Center

General Accounting Office, Washington, DC. Div. of Human Resources.

This report is a resource document which includes a catalog that explains how formulas for federal programs are used to allocate assistance to state and local governments. In addition, it provides information on the agencies and congressional committees that have jurisdiction over these programs, the amount of money allocated through these…

7 CFR 761.205 - Computing the formula allocation.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GENERAL PROGRAM ADMINISTRATION Allocation of Farm Loan Programs... held in the National Office reserve and distributed by base and administrative allocation, multiplied... allocation−national reserve−base allocation−administrative allocation) × State Factor (b) To calculate the...

[Need-based resource allocation--experiences with the RAWP formula in Great Britain].

PubMed

Brand, H; Menke, R

1997-07-01

The RAWP formula used for resource allocation in Great Britain between 1976 and 1991 is a morbidity-oriented instrument of controlling, which has so far received only little attention in Germany. The development of this model was supported by the intention to intervene in the regional pattern of hospital supply by means of resource allocation and to refine it according to the guiding principles of equity and efficiency. The basic elements-regional population, average bed use, ICD chapter-specific SMRs-are discussed and the various modifications outlined. The RAWP formula's potentials of controlling resulted in a progressive reduction of the apparent disparities between regions in hospital supply, and knee was considered to be a "qualified success". The future development in the sense of an internal market addressed.

24 CFR 982.101 - Allocation of funding.

Code of Federal Regulations, 2011 CFR

2011-04-01

... housing budget authority. Some budget authority is exempt by law from allocation under section 213(d). Unless exempted by law, budget authority for the tenant-based programs must be allocated in accordance... law; (ii) funding incapable of geographic formula allocation (e.g., for renewal of expiring funding...

24 CFR 982.101 - Allocation of funding.

Code of Federal Regulations, 2010 CFR

2010-04-01

... housing budget authority. Some budget authority is exempt by law from allocation under section 213(d). Unless exempted by law, budget authority for the tenant-based programs must be allocated in accordance... law; (ii) funding incapable of geographic formula allocation (e.g., for renewal of expiring funding...

Mitigation of inbreeding while preserving genetic gain in genomic breeding programs for outbred plants.

PubMed

Lin, Zibei; Shi, Fan; Hayes, Ben J; Daetwyler, Hans D

2017-05-01

Heuristic genomic inbreeding controls reduce inbreeding in genomic breeding schemes without reducing genetic gain. Genomic selection is increasingly being implemented in plant breeding programs to accelerate genetic gain of economically important traits. However, it may cause significant loss of genetic diversity when compared with traditional schemes using phenotypic selection. We propose heuristic strategies to control the rate of inbreeding in outbred plants, which can be categorised into three types: controls during mate allocation, during selection, and simultaneous selection and mate allocation. The proposed mate allocation measure GminF allocates two or more parents for mating in mating groups that minimise coancestry using a genomic relationship matrix. Two types of relationship-adjusted genomic breeding values for parent selection candidates ([Formula: see text]) and potential offspring ([Formula: see text]) are devised to control inbreeding during selection and even enabling simultaneous selection and mate allocation. These strategies were tested in a case study using a simulated perennial ryegrass breeding scheme. As compared to the genomic selection scheme without controls, all proposed strategies could significantly decrease inbreeding while achieving comparable genetic gain. In particular, the scenario using [Formula: see text] in simultaneous selection and mate allocation reduced inbreeding to one-third of the original genomic selection scheme. The proposed strategies are readily applicable in any outbred plant breeding program.

78 FR 51735 - Notice of FY 2013 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... Refugee Social Services formula awards to States and Wilson/Fish Alternative Project grantees. The FY 2013 formula allocations for Social Services are available on ORR's Web site at: http://www.acf.hhs.gov...] Notice of FY 2013 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative Project...

11 CFR 106.4 - Allocation of polling expenses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Allocation of polling expenses. 106.4 Section... ACTIVITIES § 106.4 Allocation of polling expenses. (a) The purchase of opinion poll results by a candidate or... cost allocation formula of the polling firm from which the results are purchased. Under this method the...

Current Subcounty Allocation Practices: Volume I of the Title I, ESEA, Subcounty Allocation Study.

ERIC Educational Resources Information Center

Paller, Alan T.; Gutmann, Babette

In this report, subcounty allocation of Title I of the Elementary and Secondary Education Act (ESEA) funds is described in terms of direct allocation, use of the statutory formula emphasizing census data, United States Office of Education (USOE) regulations, participating states, geographic and administrative overlaps, hold harmless adjustments…

Allocation of Resources to Communication of Research Result Summaries.

PubMed

Richards, Julie E; Bane, Emmi; Fullerton, Stephanie M; Ludman, Evette J; Jarvik, Gail

2016-10-01

Researchers and policymakers recommend communicating summary research results to biobank participants when feasible. To date, however, there have been few explorations of participant preferences for dedicating resources to this activity. Fifteen semi-structured interviews were conducted with participants of a genetic medicine biobank. Participants were interviewed by phone about their motivation for participation, and opinions about the allocation of resources to communicating summary results. De-identified transcripts were used for a directed content analysis. Most biobank participation was altruistic. All participants were not only interested in receiving summary results but also expressed a clear preference for allocating limited funds to conducting additional genetic research. The results suggest that participants have a nuanced view about the allocation of biobank resources to returning summary results, and asking their opinion is a valuable exercise. Researchers may benefit from transparency about research goals and involving biobank participants in decisions about return of summary results.

24 CFR 791.403 - Allocation of housing assistance.

Code of Federal Regulations, 2012 CFR

2012-04-01

... as needed for uses that the Secretary determines are incapable of geographic allocation by formula... prescribed set-aside, is, in the determination of the Secretary, incapable of geographic allocation by... programs authorized by the Cranston-Gonzalez National Affordable Housing Act: the Homeownership and...

49 CFR 198.13 - Grant allocation formula.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 1993, the Administrator places increasing emphasis on program performance in allocating state agency... provided in the state's annual certification/agreement attachments which document its activities for the...

49 CFR 198.13 - Grant allocation formula.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 1993, the Administrator places increasing emphasis on program performance in allocating state agency... provided in the state's annual certification/agreement attachments which document its activities for the...

24 CFR 1000.326 - What if a formula area is served by more than one Indian tribe?

Code of Federal Regulations, 2012 CFR

2012-04-01

... § 1000.326 What if a formula area is served by more than one Indian tribe? (a) If an Indian tribe's formula area overlaps with the formula area of one or more other Indian tribes, the funds allocated to... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false What if a formula area is served by...

24 CFR 1000.326 - What if a formula area is served by more than one Indian tribe?

Code of Federal Regulations, 2010 CFR

2010-04-01

... § 1000.326 What if a formula area is served by more than one Indian tribe? (a) If an Indian tribe's formula area overlaps with the formula area of one or more other Indian tribes, the funds allocated to... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false What if a formula area is served by...

24 CFR 1000.326 - What if a formula area is served by more than one Indian tribe?

Code of Federal Regulations, 2013 CFR

2013-04-01

... § 1000.326 What if a formula area is served by more than one Indian tribe? (a) If an Indian tribe's formula area overlaps with the formula area of one or more other Indian tribes, the funds allocated to... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false What if a formula area is served by...

24 CFR 1000.326 - What if a formula area is served by more than one Indian tribe?

Code of Federal Regulations, 2014 CFR

2014-04-01

... § 1000.326 What if a formula area is served by more than one Indian tribe? (a) If an Indian tribe's formula area overlaps with the formula area of one or more other Indian tribes, the funds allocated to... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false What if a formula area is served by...

24 CFR 1000.326 - What if a formula area is served by more than one Indian tribe?

Code of Federal Regulations, 2011 CFR

2011-04-01

... § 1000.326 What if a formula area is served by more than one Indian tribe? (a) If an Indian tribe's formula area overlaps with the formula area of one or more other Indian tribes, the funds allocated to... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false What if a formula area is served by...

49 CFR Appendix D to Part 222 - Determining Risk Levels

Code of Federal Regulations, 2012 CFR

2012-10-01

... collision probability. There are three formulas, one for each warning device category: 1. automatic gates... risk for all public highway-rail grade crossings that are part of a quiet zone. The Prediction Formulas (a) The Prediction Formulas were developed by DOT as a guide for allocating scarce traffic safety...

45 CFR 1385.8 - Formula for determining allotments.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Formula for determining allotments. 1385.8 Section... Formula for determining allotments. The Commissioner will allocate funds appropriated under the Act for.... (b) One-third of the amount appropriated is allotted to each State on the basis of the relative need...

49 CFR Appendix D to Part 222 - Determining Risk Levels

Code of Federal Regulations, 2014 CFR

2014-10-01

... collision probability. There are three formulas, one for each warning device category: 1. automatic gates... risk for all public highway-rail grade crossings that are part of a quiet zone. The Prediction Formulas (a) The Prediction Formulas were developed by DOT as a guide for allocating scarce traffic safety...

49 CFR Appendix D to Part 222 - Determining Risk Levels

Code of Federal Regulations, 2013 CFR

2013-10-01

... collision probability. There are three formulas, one for each warning device category: 1. automatic gates... risk for all public highway-rail grade crossings that are part of a quiet zone. The Prediction Formulas (a) The Prediction Formulas were developed by DOT as a guide for allocating scarce traffic safety...

45 CFR 1385.8 - Formula for determining allotments.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Formula for determining allotments. 1385.8 Section... Formula for determining allotments. The Commissioner will allocate funds appropriated under the Act for.... (b) One-third of the amount appropriated is allotted to each State on the basis of the relative need...

45 CFR 1385.8 - Formula for determining allotments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Formula for determining allotments. 1385.8 Section... Formula for determining allotments. The Commissioner will allocate funds appropriated under the Act for.... (b) One-third of the amount appropriated is allotted to each State on the basis of the relative need...

Factors influencing resource allocation decisions and equity in the health system of Ghana.

PubMed

Asante, A D; Zwi, A B

2009-05-01

Allocation of financial resources in the health sector is often seen as a formula-driven activity. However, the decision to allocate a certain amount of resources to a particular health jurisdiction or facility may be based on a broader range of factors, sometimes not reflected in the existing resource allocation formula. This study explores the 'other' factors that influence the equity of resource allocation in the health system of Ghana. The extent to which these factors are, or can be, accounted for in the resource allocation process is analysed. An exploratory design focusing on different levels of the health system and diverse stakeholders. Data were gathered through semi-structured qualitative interviews with health authorities at national, regional and district levels, and with donor representatives and local government officials in 2003 and 2004. The availability of human resources for health, local capacity to utilize funds, donor involvement in the health sector, and commitment to promote equity have considerable influence on resource allocation decisions and affect the equity of funding allocations. However, these factors are not accounted for adequately in the resource allocation process. This study highlights the need for a more transparent resource allocation system in Ghana based on needs, and takes into account key issues such as capacity constraints, the inequitable human resource distribution and donor-earmarked funding.

24 CFR 92.66 - Reallocation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.66 Reallocation. Any HOME funds... allocation amount for one or more of the remaining insular areas as provided in § 92.60 of this part, will be...

24 CFR 92.66 - Reallocation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.66 Reallocation. Any HOME funds... allocation amount for one or more of the remaining insular areas as provided in § 92.60 of this part, will be...

24 CFR 92.66 - Reallocation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.66 Reallocation. Any HOME funds... allocation amount for one or more of the remaining insular areas as provided in § 92.60 of this part, will be...

24 CFR 92.66 - Reallocation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.66 Reallocation. Any HOME funds... allocation amount for one or more of the remaining insular areas as provided in § 92.60 of this part, will be...

24 CFR 92.66 - Reallocation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.66 Reallocation. Any HOME funds... allocation amount for one or more of the remaining insular areas as provided in § 92.60 of this part, will be...

Funding Education: Developing a Method of Allocation for Improvement

ERIC Educational Resources Information Center

BenDavid-Hadar, Iris

2018-01-01

Purpose: Resource allocation is a key policy instrument that affects the educational achievement distribution (EAD). The literature on methods of allocation is focused mainly on equity issues. The purpose of this paper is to develop a composite funding formula, which adds to the equity-based element (i.e. a needs-based element compensating for…

20 CFR 668.296 - How are WIA funds allocated to INA grantees?

Code of Federal Regulations, 2012 CFR

2012-04-01

... of the funds calculated under the following formula: (1) One-quarter of the funds available will be... the United States. (3) The data and definitions used to implement these formulas is provided by the U.S. Bureau of the Census. (c) In years immediately following the use of new data in the formula...

24 CFR 1000.58 - Are there limitations on the investment of IHBG funds?

Code of Federal Regulations, 2011 CFR

2011-04-01

... of the funds, even in the event of bank failure. (d) IHBG funds shall be held in one or more accounts... in an amount equal to the annual formula grant amount less any formula grant amounts allocated for the operating subsidy element of the Formula Current Assisted Housing Stock (FCAS) component of the...

20 CFR 668.296 - How are WIA funds allocated to INA grantees?

Code of Federal Regulations, 2014 CFR

2014-04-01

... of the funds calculated under the following formula: (1) One-quarter of the funds available will be... the United States. (3) The data and definitions used to implement these formulas is provided by the U.S. Bureau of the Census. (c) In years immediately following the use of new data in the formula...

The Implications of Fiscal Incentives on Identification Rates and Placement in Special Education: Formulas for Influencing Best Practice

ERIC Educational Resources Information Center

Mahitivanichcha, Kanya; Parrish, Thomas

2005-01-01

This article explores possible fiscal incentives associated with various state formulas for allocating special education funds and the degree to which such incentives affect special education. First we review empirical and contextual evidence in the literature that addresses the relationship between funding formulas and special education…

78 FR 51736 - Notice of FY 2013 Refugee Targeted Assistance Formula Awards to States and Wilson/Fish...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

...The Office of Refugee Resettlement (ORR), Administration for Children and Families (ACF), announces the allocation of Refugee Targeted Assistance formula awards to States and Wilson/Fish Alternative Project grantees.

Equalizing Matching Grants and the Allocative and Distributive Objectives of Public School Financing

ERIC Educational Resources Information Center

Gatti, James F.; Tashman, Leonard J.

1976-01-01

Argues that typical Equalizing Matching Grant (EMG) systems for distributing state school aid cannot be expected to achieve the allocative and distributive goals of school finance. Derives a generalized EMG system and specific school aid formula that satisfy the allocative and distributive criteria. Available from: NTA-TIA, 21 East State Street,…

47 CFR 1.1417 - Allocation of Unusable Space Costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 1 2011-10-01 2011-10-01 false Allocation of Unusable Space Costs. 1.1417... Attachment Complaint Procedures § 1.1417 Allocation of Unusable Space Costs. (a) With respect to the formula referenced in § 1.1409(e)(2), a utility shall apportion the cost of providing unusable space on a pole so...

47 CFR 1.1417 - Allocation of Unusable Space Costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Allocation of Unusable Space Costs. 1.1417... Attachment Complaint Procedures § 1.1417 Allocation of Unusable Space Costs. (a) With respect to the formula referenced in § 1.1409(e)(2), a utility shall apportion the cost of providing unusable space on a pole so...

A cost-sharing formula for online circulation and a union catalog through a regional, multitype library cooperative.

PubMed Central

Arcari, R D

1987-01-01

The experience of the Capitol Region Library Council and the University of Connecticut Health Center in developing a cost allocation formula for a circulation and online catalog shared by twenty-nine libraries is reviewed. The resulting formula identifies a basic unit cost as a minimum for each system participant. PMID:3676536

76 FR 78703 - American Century Strategic Asset Allocations, Inc., et al.;

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-19

.... Summary of Application: Applicants request an order to permit open-end management investment companies... Century Strategic Asset Allocations, Inc. (``ACSAA''), American Century Investment Management, Inc... Management, Office of Investment Company Regulation). SUPPLEMENTARY INFORMATION: The following is a summary...

Chapter 2 Formula. 1986-87 Final Report.

ERIC Educational Resources Information Center

Moede, Lauren Hall

For the 1986-87 school year, the Austin (Texas) Independent School District (AISD) allocated its Education Consolidation Improvement Act (ECIA) Chapter 2 Formula and Carry-over funds to nine desegregation-related programs: (1) Bus Monitors; (2) Extracurricular Transportation; (3) Outdoor Learning; (4) Peer Assistance and Leadership; (5) Project…

75 FR 32495 - Operating Fund Subsidies Allocation Formula

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5376-N-49] Operating Fund Subsidies... establishes an Operating Fund for the purpose of making assistance available to public housing agencies (PHAs) which assistance is determined using a formula approach under the Operating Fund Program. PHAs compute...

7 CFR 1466.5 - National allocation and management.

Code of Federal Regulations, 2010 CFR

2010-01-01

... adjustments to national priorities and information about resource concerns and program performance. The data used in the allocation formula will be updated as they become available. (b) Provide a performance...) Establish State level EQIP performance goals based on national, regional, and State priorities. (d) Ensure...

Ising game: Nonequilibrium steady states of resource-allocation systems

NASA Astrophysics Data System (ADS)

Xin, C.; Yang, G.; Huang, J. P.

2017-04-01

Resource-allocation systems are ubiquitous in the human society. But how external fields affect the state of such systems remains poorly explored due to the lack of a suitable model. Because the behavior of spins pursuing energy minimization required by physical laws is similar to that of humans chasing payoff maximization studied in game theory, here we combine the Ising model with the market-directed resource-allocation game, yielding an Ising game. Based on the Ising game, we show theoretical, simulative and experimental evidences for a formula, which offers a clear expression of nonequilibrium steady states (NESSs). Interestingly, the formula also reveals a convertible relationship between the external field (exogenous factor) and resource ratio (endogenous factor), and a class of saturation as the external field exceeds certain limits. This work suggests that the Ising game could be a suitable model for studying external-field effects on resource-allocation systems, and it could provide guidance both for seeking more relations between NESSs and equilibrium states and for regulating human systems by choosing NESSs appropriately.

Budgeting based on need: a model to determine sub-national allocation of resources for health services in Indonesia

PubMed Central

2012-01-01

Background Allocating national resources to regions based on need is a key policy issue in most health systems. Many systems utilise proxy measures of need as the basis for allocation formulae. Increasingly these are underpinned by complex statistical methods to separate need from supplier induced utilisation. Assessment of need is then used to allocate existing global budgets to geographic areas. Many low and middle income countries are beginning to use formula methods for funding however these attempts are often hampered by a lack of information on utilisation, relative needs and whether the budgets allocated bear any relationship to cost. An alternative is to develop bottom-up estimates of the cost of providing for local need. This method is viable where public funding is focused on a relatively small number of targeted services. We describe a bottom-up approach to developing a formula for the allocation of resources. The method is illustrated in the context of the state minimum service package mandated to be provided by the Indonesian public health system. Methods A standardised costing methodology was developed that is sensitive to the main expected drivers of local cost variation including demographic structure, epidemiology and location. Essential package costing is often undertaken at a country level. It is less usual to utilise the methods across different parts of a country in a way that takes account of variation in population needs and location. Costing was based on best clinical practice in Indonesia and province specific data on distribution and costs of facilities. The resulting model was used to estimate essential package costs in a representative district in each province of the country. Findings Substantial differences in the costs of providing basic services ranging from USD 15 in urban Yogyakarta to USD 48 in sparsely populated North Maluku. These costs are driven largely by the structure of the population, particularly numbers of births, infants and children and also key diseases with high cost/prevalence and variation, most notably the level of malnutrition. The approach to resource allocation was implemented using existing data sources and permitted the rapid construction of a needs based formula that is highly specific to the package mandated across the country. Refinement could focus more on resources required to finance demand side costs and expansion of the service package to include priority non-communicable services. PMID:22931536

Budgeting based on need: a model to determine sub-national allocation of resources for health services in Indonesia.

PubMed

Ensor, Tim; Firdaus, Hafidz; Dunlop, David; Manu, Alex; Mukti, Ali Ghufron; Ayu Puspandari, Diah; von Roenne, Franz; Indradjaya, Stephanus; Suseno, Untung; Vaughan, Patrick

2012-08-29

Allocating national resources to regions based on need is a key policy issue in most health systems. Many systems utilise proxy measures of need as the basis for allocation formulae. Increasingly these are underpinned by complex statistical methods to separate need from supplier induced utilisation. Assessment of need is then used to allocate existing global budgets to geographic areas. Many low and middle income countries are beginning to use formula methods for funding however these attempts are often hampered by a lack of information on utilisation, relative needs and whether the budgets allocated bear any relationship to cost. An alternative is to develop bottom-up estimates of the cost of providing for local need. This method is viable where public funding is focused on a relatively small number of targeted services. We describe a bottom-up approach to developing a formula for the allocation of resources. The method is illustrated in the context of the state minimum service package mandated to be provided by the Indonesian public health system. A standardised costing methodology was developed that is sensitive to the main expected drivers of local cost variation including demographic structure, epidemiology and location. Essential package costing is often undertaken at a country level. It is less usual to utilise the methods across different parts of a country in a way that takes account of variation in population needs and location. Costing was based on best clinical practice in Indonesia and province specific data on distribution and costs of facilities. The resulting model was used to estimate essential package costs in a representative district in each province of the country. Substantial differences in the costs of providing basic services ranging from USD 15 in urban Yogyakarta to USD 48 in sparsely populated North Maluku. These costs are driven largely by the structure of the population, particularly numbers of births, infants and children and also key diseases with high cost/prevalence and variation, most notably the level of malnutrition. The approach to resource allocation was implemented using existing data sources and permitted the rapid construction of a needs based formula that is highly specific to the package mandated across the country. Refinement could focus more on resources required to finance demand side costs and expansion of the service package to include priority non-communicable services.

Seizing the Moment for Transformation: California's Local Control Funding Formula

ERIC Educational Resources Information Center

Miles, Karen Hawley; Feinberg, Randi

2014-01-01

In 2013 California adopted a new funding formula that includes a significant reinvestment in public education after years of budget cuts. The new law allocates funds differently, directing more resources to students with higher needs and providing more local control and greater transparency. This revolutionary change presents California districts…

The Campus-Based Formula. NASFAA Task Force Report

ERIC Educational Resources Information Center

National Association of Student Financial Aid Administrators, 2014

2014-01-01

The primary purpose of the National Association of Student Financial Aid Administrators (NASFAA) Campus-Based Aid Allocation Task Force was to examine the formula by which congressional appropriations for the Federal Supplemental Educational Opportunity Grant (FSEOG), Federal Work-Study (FWS), and Perkins Loan programs are distributed to schools,…

15 CFR 923.110 - Allocation formula.

Code of Federal Regulations, 2010 CFR

2010-01-01

... MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Allocation of Section 306 Program Administration... Coastal Zone Act Reauthorization Amendments of 1990, 1 to 1 for any fiscal year. (2) For programs approved after enactment of the Coastal Zone Act Reauthorization Amendments of 1990, 4 to 1 for the first fiscal...

15 CFR 923.110 - Allocation formula.

Code of Federal Regulations, 2011 CFR

2011-01-01

... MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Allocation of Section 306 Program Administration... Coastal Zone Act Reauthorization Amendments of 1990, 1 to 1 for any fiscal year. (2) For programs approved after enactment of the Coastal Zone Act Reauthorization Amendments of 1990, 4 to 1 for the first fiscal...

20 CFR 631.32 - Allocation of funds by the Governor.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 631.32 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROGRAMS UNDER TITLE III OF THE JOB TRAINING PARTNERSHIP ACT State Administration § 631.32 Allocation of funds by... for an appropriate weight for each of the formula factors set forth in paragraph (b)(2) of this...

Subregional resource allocations in the National Health Service.

PubMed Central

Snaith, A H

1978-01-01

The Resource Allocation Working Party in its report Sharing Resources for Health in England proposes a formula for the identification of both regional and district financial targets (Department of Health and Social Security, 1976). In this paper it is argued that the national formula is not a valid instrument for the latter purpose. Furthermore, research into medical needs and outcomes will not be adequate to bring about real changes in resource distribution at local levels unless it is recognised that the health authorities can meet needs in different ways and that a change in resource management from institutional to service budgeting is required. PMID:262582

24 CFR 905.10 - Capital Fund formula (CFF).

Code of Federal Regulations, 2011 CFR

2011-04-01

...-based assistance in accordance with section 8 of the U.S. Housing Act of 1937 (42 U.S.C. 1437f). (3) The... Federal Register notice. (c) Formula allocation based on relative needs. After determining the amounts to... Capital Fund amount based on the relative existing modernization needs of PHAs, determined in accordance...

Elementary and Secondary Education Act of 1965: Allocation Methods. CRS Report for Congress.

ERIC Educational Resources Information Center

Irwin, Paul M.

The Elementary Secondary Education Act (ESEA) of 1965 authorizes 39 programs that are administered by the United States Department of Education and account for $8.6 billion in FY 1993. ESEA funds are distributed through three allocation methods: formulas, discretionary grants, and specifically designated recipients. Almost half of ESEA programs…

Campus-Based Financial Aid Programs: Trends and Alternative Allocation Strategies

ERIC Educational Resources Information Center

Kelchen, Robert

2017-01-01

Two federal campus-based financial aid programs, the Supplemental Educational Opportunity Grant (SEOG) and the Federal Work-Study Program (FWS), combine to provide nearly US$2 billion in funding to students with financial need. However, the allocation formulas have changed little since 1965, resulting in community colleges and newer institutions…

76 FR 45551 - Post-2014 Resource Pool; Loveland Area Projects, Proposed Power Allocation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-29

... Proposed Power Allocation. SUMMARY: Western Area Power Administration (Western), a Federal power marketing... Pool Proposed Power Allocation developed under the requirements of the Power Marketing Initiative of Western's Energy Planning and Management Program (Program). Western notified the public of allocation...

76 FR 548 - Central Arizona Project-Rate Order No. WAPA-153

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... Transmission Formula Rates. SUMMARY: This action is to extend the existing Central Arizona Project (CAP) formula rates through December 31, 2012. The existing Transmission Service Formula Rate Schedules CAP-FT2, CAP-NFT2, and CAP- NITS2 expire on December 31, 2010. These Transmission Service Rate Schedules...

The Massachusetts Community College Performance-Based Funding Formula: A New Model for New England?

ERIC Educational Resources Information Center

Salomon-Fernandez, Yves

2014-01-01

The Massachusetts community college system is entering a second year with funding for each of its 15 schools determined using a new performance-based formula. Under the new model, 50% of each college's allocation is based on performance on metrics related to enrollment and student success, with added incentives for "at-risk" students…

Review of the Ontario Operating Grants Formula. Interim Report.

ERIC Educational Resources Information Center

Council of Ontario Universities, Toronto.

The Operating Grants Formula utilized by the Council of Ontario Universities, has as its sole purpose to provide an objective mechanism for determining the share of the total provincial operating grant to be allocated to each university. It is not intended to limit or control the expenditure of funds granted to the universities, but institutions…

78 FR 5775 - Notice of Allocation of Tariff Rate Quotas (TRQ) on the Import of Certain Worsted Wool Fabrics...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... DEPARTMENT OF COMMERCE International Trade Administration Notice of Allocation of Tariff Rate... Trade Administration, Department of Commerce. ACTION: Notice of allocation of 2013 worsted wool fabric tariff rate quota. SUMMARY: The Department of Commerce (Department) has determined the allocation for...

Optimum sample size allocation to minimize cost or maximize power for the two-sample trimmed mean test.

PubMed

Guo, Jiin-Huarng; Luh, Wei-Ming

2009-05-01

When planning a study, sample size determination is one of the most important tasks facing the researcher. The size will depend on the purpose of the study, the cost limitations, and the nature of the data. By specifying the standard deviation ratio and/or the sample size ratio, the present study considers the problem of heterogeneous variances and non-normality for Yuen's two-group test and develops sample size formulas to minimize the total cost or maximize the power of the test. For a given power, the sample size allocation ratio can be manipulated so that the proposed formulas can minimize the total cost, the total sample size, or the sum of total sample size and total cost. On the other hand, for a given total cost, the optimum sample size allocation ratio can maximize the statistical power of the test. After the sample size is determined, the present simulation applies Yuen's test to the sample generated, and then the procedure is validated in terms of Type I errors and power. Simulation results show that the proposed formulas can control Type I errors and achieve the desired power under the various conditions specified. Finally, the implications for determining sample sizes in experimental studies and future research are discussed.

75 FR 14596 - Family Violence Prevention and Services/Grants for Domestic Violence Shelters/Grants to Native...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-26

..., isolation from family and friends, harm to children living with a parent or caretaker who is either... communities compound the basic dynamics of family violence. Barriers such as the isolation of vast rural areas.... The formula has two parts, the Tribal population base allocation and a population category allocation...

75 FR 57912 - Boulder Canyon Project-Rate Order No. WAPA-150

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

...-setting Formula and Approval of FY 2011 Base Charge and Rates. SUMMARY: The Deputy Secretary of Energy... existing Boulder Canyon Project (BCP) rate-setting formula and approving the base charge and rates for FY... financial and load data. The existing rate-setting formula is being extended under Rate Order No. WAPA-150...

Formula Funding and Decentralized Management of Schools--Has It Improved Resource Allocation in Schools in Sri Lanka?

ERIC Educational Resources Information Center

Arunatilake, Nisha; Jayawardena, Priyanka

2010-01-01

Using the experience of the Educational Quality Inputs (EQI) Scheme in Sri Lanka the paper examines the distributional aspects of formula-based funding and efficiency of decentralized management of education funds in a developing country setting. The study finds that the EQI fund distribution is largely pro-poor. However, results show that to…

Formula-Based Public School Funding System in Victoria: An Empirical Analysis of Equity

ERIC Educational Resources Information Center

Bandaranayake, Bandara

2013-01-01

This article explores the formula-based school funding system in the state of Victoria, Australia, where state funds are directly allocated to schools based on a range of equity measures. The impact of Victoria' funding system for education in terms of alleviating inequality and disadvantage is contentious, to say the least. It is difficult to…

Fostering Innovation: How User-Centered Design Can Help Us Get the Local Control Funding Formula Right. Policy and Practice Brief

ERIC Educational Resources Information Center

Knudson, Joel; Ramanathan, Arun; Carter, Allison; O'Day, Jennifer

2017-01-01

The Local Control Funding Formula (LCFF) has introduced positive and much-needed change to California's approach to K-12 education funding by allocating resources according to student need and freeing districts to make decisions that address local priorities. For all of LCFF's advantages, however, the Local Control Accountability Plans (LCAPs) in…

20 CFR 667.210 - What administrative cost limits apply to Workforce Investment Act title I grants?

Code of Federal Regulations, 2012 CFR

2012-04-01

... Workforce Investment Act title I grants? (a) Formula grants to States: (1) As part of the 15 percent that a... formula grants are limited to no more than ten percent (10%) of the amount allocated to the local area... be identified in the grant or contract award document. (c) In a One-Stop environment, administrative...

Paving the Way to Equity and Coherence? The Local Control Funding Formula in Year 3

ERIC Educational Resources Information Center

Humphrey, Daniel; Koppich, Julia; Lavadenz, Magaly; Marsh, Julie; O'Day, Jennifer; Plank, David; Stokes, Laura; Hall, Michelle

2017-01-01

This report is the third in a series by the Local Control Funding Formula Research Collaborative (LCFFRC). This research seeks to help policymakers and others better understand ways in which the LCFF is changing fundamental aspects of resource allocation and governance and how these changes might lead to improved student outcomes. The work is…

Development of a resource allocation formula for substance misuse treatment services.

PubMed

Jones, Andrew; Hayhurst, Karen P; Whittaker, Will; Mason, Thomas; Sutton, Matt

2017-11-23

Funding for substance misuse services comprises one-third of Public Health spend in England. The current allocation formula contains adjustments for actual activity, performance and need, proxied by the Standardized Mortality Ratio for under-75s (SMR < 75). Additional measures, such as deprivation, may better identify differential service need. We developed an age-standardized and an age-stratified model (over-18s, under-18s), with the outcome of expected/actual cost at postal sector/Local Authority level. A third, person-based model incorporated predictors of costs at the individual level. Each model incorporated both needs and supply variables, with the relative effects of their inclusion assessed. Mean estimated annual cost (2013/14) per English Local Authority area was £5 032 802 (sd: 3 951 158). Costs for drug misuse treatment represented the majority (83%) of costs. Models achieved adjusted R-squared values of 0.522 (age-standardized), 0.533 (age-stratified over-18s), 0.232 (age-stratified under-18s) and 0.470 (person-based). Improvements can be made to the existing resource allocation formulae to better reflect population need. The person-based model permits inclusion of a range of needs variables, in addition to strong predictors of cost based on the receipt of treatment in the previous year. Adoption of this revised person-based formula for substance misuse would shift resources towards more deprived areas. © The Author 2017. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

75 FR 67983 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-04

...; Infant Formula Requirements AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing that a collection of information entitled ``Infant Formula...

Load and resistance factor design calibration to determine a resistance factor for the modification of the Kansas Department of Transportation-Engineering News Record formula : [technical summary].

DOT National Transportation Integrated Search

2014-02-01

The Kansas Department of Transportation (KDOT) has, in recent years, used a : variation of the Engineering News Record (ENR) formula to determine the capacity of : piles in the field. It was a concern that the KDOT-ENR formula was under-predicting : ...

Educational Resource Allocation at the Elementary Level: A Case Study of One Elementary School District in California

ERIC Educational Resources Information Center

Nguyen, Dominic

2013-01-01

The purpose of this study was to examine the dispersion of human capital resources within one school district in southern California and compare the use of personnel at each school to the desired allocation informed by the district's strategies and staffing formula. The district's resource distribution was also compared to that of the Evidence…

Funding Formulas for California Schools IV: An Analysis of Governor Brown's Weighted Pupil Funding Formula, May Budget Revision

ERIC Educational Resources Information Center

Rose, Heather; Sonstelie, Jon; Weston, Margaret

2012-01-01

In his 2012-13 budget, Governor Brown proposed a new system for allocating state revenue among California school districts. In May the governor revised his proposal. Using the Public Policy Institute of California (PPIC) School Finance Model (available at www.ppic.org/main/dataSet.asp?i=1229), in this update the authors show how these proposals…

49 CFR 244.9 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... railroad operations, including, but not limited to, the allocation of resources affecting railroad... deflator formula) from time to time. Corporate culture means the totality of the commitments, written and...

49 CFR 244.9 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... railroad operations, including, but not limited to, the allocation of resources affecting railroad... deflator formula) from time to time. Corporate culture means the totality of the commitments, written and...

49 CFR 244.9 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... railroad operations, including, but not limited to, the allocation of resources affecting railroad... deflator formula) from time to time. Corporate culture means the totality of the commitments, written and...

49 CFR 244.9 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... railroad operations, including, but not limited to, the allocation of resources affecting railroad... deflator formula) from time to time. Corporate culture means the totality of the commitments, written and...

12 CFR 1261.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... includes guaranteed directorships and stock directorships. Method of equal proportions means the mathematical formula used by FHFA to allocate member directorships among the States in a Bank's district based...

The fundamental closed-form solution of control-related states of kth order S3PR system with left-side non-sharing resource places of Petri nets

NASA Astrophysics Data System (ADS)

Chao, Daniel Yuh; Yu, Tsung Hsien

2016-01-01

Due to the state explosion problem, it has been unimaginable to enumerate reachable states for Petri nets. Chao broke the barrier earlier by developing the very first closed-form solution of the number of reachable and other states for marked graphs and the kth order system. Instead of using first-met bad marking, we propose 'the moment to launch resource allocation' (MLR) as a partial deadlock avoidance policy for a large, real-time dynamic resource allocation system. Presently, we can use the future deadlock ratio of the current state as the indicator of MLR due to which the ratio can be obtained real-time by a closed-form formula. This paper progresses the application of an MLR concept one step further on Gen-Left kth order systems (one non-sharing resource place in any position of the left-side process), which is also the most fundamental asymmetric net structure, by the construction of the system's closed-form solution of the control-related states (reachable, forbidden, live and deadlock states) with a formula depending on the parameters of k and the location of the non-sharing resource. Here, we kick off a new era of real-time, dynamic resource allocation decisions by constructing a generalisation formula of kth order systems (Gen-Left) with r* on the left side but at arbitrary locations.

7 CFR 1468.30 - Appeals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... allocations; (2) Eligible conservation practices; (3) Payment rates, and cost-share percentages; (4) Science-based formulas and factor values; (5) Soils mapping and information; and (6) Other matters of general...

7 CFR 1468.30 - Appeals.

Code of Federal Regulations, 2013 CFR

2013-01-01

... allocations; (2) Eligible conservation practices; (3) Payment rates, and cost-share percentages; (4) Science-based formulas and factor values; (5) Soils mapping and information; and (6) Other matters of general...

7 CFR 1468.30 - Appeals.

Code of Federal Regulations, 2012 CFR

2012-01-01

... allocations; (2) Eligible conservation practices; (3) Payment rates, and cost-share percentages; (4) Science-based formulas and factor values; (5) Soils mapping and information; and (6) Other matters of general...

7 CFR 1468.30 - Appeals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... allocations; (2) Eligible conservation practices; (3) Payment rates, and cost-share percentages; (4) Science-based formulas and factor values; (5) Soils mapping and information; and (6) Other matters of general...

Cost Allocation and Overpricing of Spare Parts.

DTIC Science & Technology

1986-09-01

5 defense contractors are presently treating spare parts as cost objectives and using a type of spare parts accounting system as described in the...survey instrument. The other 7 contractor respondents who do not treat spare parts as cost objectives were not favor- able to this accounting treatment...company accounting systems or lised to resolve specific contract or formula pricing cost allocation issues, contribute signi- ficantly to overpricing

2012 statistical summaries : FTA grant assistance programs.

DOT National Transportation Integrated Search

2013-12-01

The 2012 Statistical Summaries provides information about the Federal Transit Administrations (FTA) major financial aid programs for : Federal Fiscal Year (FY) 2012. The report covers the following programs: Urbanized Area Formula, Non-urbanized A...

2011 statistical summaries : FTA grant assistance programs.

DOT National Transportation Integrated Search

2013-05-01

The 2011 Statistical Summaries provides information about the Federal Transit Administrations (FTA) major financial aid programs for Federal Fiscal Year (FY) 2011. The report covers the following programs: Urbanized Area Formula, Non-urbanized Are...

2010 statistical summaries : FTA grant assistance programs.

DOT National Transportation Integrated Search

2013-07-01

The 2010 Statistical Summaries provides information about the Federal Transit Administrations (FTA) major financial aid programs for Federal Fiscal Year (FY) 2010. The report covers the following programs: Urbanized Area Formula, Non-urbanized Are...

American Recovery and Reinvestment Act (ARRA) statistical summaries.

DOT National Transportation Integrated Search

2012-05-01

The American Recovery and Reinvestment Act (ARRA) Statistical Summaries provide information about the Federal Transit Administrations (FTA) financial investment programs funded through ARRA.This report covers the Urbanized Area Formula Program and...

76 FR 64085 - Post-2014 Resource Pool-Loveland Area Projects, Final Power Allocation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

... power allocation. SUMMARY: The Western Area Power Administration (Western), a Federal power marketing..., Final Power Allocation developed under the requirements of subpart C-Power Marketing Initiative of the Energy Planning and Management Program (Program) Final Rule, 10 CFR part 905. These final power...

1998 statistical summaries : Federal Transit Administration : grant assistance programs

DOT National Transportation Integrated Search

1999-03-01

The 1998 Statistical Summaries provides information about the Federal Transit Administration's (FTA) major financial aid programs for Federal Fiscal Year (FY) 1998. The report covers the following programs: Urbanized Area Formula, Non-urbanized Area ...

24 CFR 574.130 - Formula allocations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... acquired immunodeficiency syndrome reported to and confirmed by the Director of the Centers for Disease Control, and on population data provided by the U.S. Census. The number of cases of acquired...

24 CFR 574.130 - Formula allocations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... immunodeficiency syndrome reported to and confirmed by the Director of the Centers for Disease Control, and on population data provided by the U.S. Census. The number of cases of acquired immunodeficiency syndrome used...

24 CFR 574.130 - Formula allocations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... acquired immunodeficiency syndrome reported to and confirmed by the Director of the Centers for Disease... immunodeficiency syndrome used for this purpose shall be the number reported as of March 31 of the fiscal year...

24 CFR 574.130 - Formula allocations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... immunodeficiency syndrome reported to and confirmed by the Director of the Centers for Disease Control, and on population data provided by the U.S. Census. The number of cases of acquired immunodeficiency syndrome used...

34 CFR 200.70 - Allocation of funds to LEAs in general.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 17, inclusive (hereinafter referred to as “formula children”)— (1) From families below the poverty... families above the poverty level receiving assistance under the Temporary Assistance for Needy Families...

34 CFR 200.70 - Allocation of funds to LEAs in general.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 17, inclusive (hereinafter referred to as “formula children”)— (1) From families below the poverty... families above the poverty level receiving assistance under the Temporary Assistance for Needy Families...

34 CFR 200.70 - Allocation of funds to LEAs in general.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 17, inclusive (hereinafter referred to as “formula children”)— (1) From families below the poverty... families above the poverty level receiving assistance under the Temporary Assistance for Needy Families...

34 CFR 200.70 - Allocation of funds to LEAs in general.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 17, inclusive (hereinafter referred to as “formula children”)— (1) From families below the poverty... families above the poverty level receiving assistance under the Temporary Assistance for Needy Families...

76 FR 11788 - Agency Information Collection Activities; Proposed Collection; Comment Request; Infant Formula...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... technology. Infant Formula Label Statements Experimental Study--(OMB Control Number 0910-NEW) FDA is planning... Statements Experimental Study will collect information from four groups: Pregnant women, mothers of infants... Statements Experimental Study AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food...

Estimated impacts of the 2010 census on the Texas transit funding formula : summary report on findings.

DOT National Transportation Integrated Search

2010-08-01

The purpose of the research for Project 0-6199, Estimated Impact of the 2010 Census on the : Texas Transit Funding Formula, is to project population growth for the 2010 Census in : urbanized and non-urbanized areas in Texas and to identify the impact...

Cost Allocation Plan for Interest Expense on Higher Education Facilities Bonds, Fiscal Year 2006

ERIC Educational Resources Information Center

Ohio Board of Regents, 2007

2007-01-01

This document supports the Cost Allocation Plan for state costs incurred on behalf of, and in benefit to, the public higher education institutions of Ohio. Tables report a summary of recalled/refunded debt and initial adjustment of Fiscal Year 2006 interest payments fore refunded debt. Attached schedules calculate the allocable interest for each…

Cost Allocation Plan for Interest Expense on Higher Education Facilities Bonds, Fiscal Year 2005

ERIC Educational Resources Information Center

Ohio Board of Regents, 2006

2006-01-01

This document supports the Cost Allocation Plan for state costs incurred on behalf of, and in benefit to, the public higher education institutions of Ohio. Tables report a summary of recalled/refunded debt and initial adjustment of Fiscal Year 2005 interest payments for refunded debt. Attached schedules calculate the allocable interest for each…

24 CFR 92.204 - Applicability of requirements to entities that receive a reallocation of HOME funds, other than...

Code of Federal Regulations, 2012 CFR

2012-04-01

... affirmative marketing requirements, labor requirements, and lead-based paint requirements, applicable to participating jurisdictions. (c) Subpart B (Allocation Formula), subpart C (Consortia; Designation and...

24 CFR 92.204 - Applicability of requirements to entities that receive a reallocation of HOME funds, other than...

Code of Federal Regulations, 2014 CFR

2014-04-01

... affirmative marketing requirements, labor requirements, and lead-based paint requirements, applicable to participating jurisdictions. (c) Subpart B (Allocation Formula), subpart C (Consortia; Designation and...

24 CFR 92.204 - Applicability of requirements to entities that receive a reallocation of HOME funds, other than...

Code of Federal Regulations, 2011 CFR

2011-04-01

... affirmative marketing requirements, labor requirements, and lead-based paint requirements, applicable to participating jurisdictions. (c) Subpart B (Allocation Formula), subpart C (Consortia; Designation and...

24 CFR 92.204 - Applicability of requirements to entities that receive a reallocation of HOME funds, other than...

Code of Federal Regulations, 2010 CFR

2010-04-01

... affirmative marketing requirements, labor requirements, and lead-based paint requirements, applicable to participating jurisdictions. (c) Subpart B (Allocation Formula), subpart C (Consortia; Designation and...

24 CFR 92.204 - Applicability of requirements to entities that receive a reallocation of HOME funds, other than...

Code of Federal Regulations, 2013 CFR

2013-04-01

... affirmative marketing requirements, labor requirements, and lead-based paint requirements, applicable to participating jurisdictions. (c) Subpart B (Allocation Formula), subpart C (Consortia; Designation and...

34 CFR 303.200 - Formula for State allocations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... aggregate amount as the number of infants and toddlers in the State bears to the number of infants and... two in the general population, based on the most recent satisfactory data as determined by the...

34 CFR 303.200 - Formula for State allocations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... aggregate amount as the number of infants and toddlers in the State bears to the number of infants and... two in the general population, based on the most recent satisfactory data as determined by the...

Rail-highway crossing accident prediction analysis

DOT National Transportation Integrated Search

1987-04-01

This report contains technical results that have been produced in a study : to revise and update the DOT rail-highway crossing resource allocation : procedure. This work has resulted in new accident prediction and severity : formulas, a modified and ...

Summary of Research 1997 Department of Systems Management.

DTIC Science & Technology

1999-01-01

formulation and execution; impacts of budget allocation , reallocation, and reduction; imple- mentation of Defense Resource Management Systems; and the...flexible structure that can be applied to a wide range of resource allocation problems. PUBLICATIONS: Dolk, D., Murphy, M., and Thomas, G...policies, procedures, and rationale in deter- mining recruiting resource allocation decisions. The methodology relies on a review of the literature

76 FR 71041 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

...; Infant Formula Recall Regulations AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing that a collection of information entitled ``Infant... entitled ``Infant Formula Recall Regulations'' to OMB for review and clearance under 44 U.S.C. 3507. An...

[Hungarian health resource allocation from the viewpoint of the English methodology].

PubMed

Fadgyas-Freyler, Petra

2018-02-01

This paper describes both the English health resource allocation and the attempt of its Hungarian adaptation. We describe calculations for a Hungarian regression model using the English 'weighted capitation formula'. The model has proven statistically correct. New independent variables and homogenous regional units have to be found for Hungary. The English method can be used with adequate variables. Hungarian patient-level health data can support a much more sophisticated model. Further research activities are needed. Orv Hetil. 2018; 159(5): 183-191.

Decentralization and equity of resource allocation: evidence from Colombia and Chile.

PubMed Central

Bossert, Thomas J.; Larrañaga, Osvaldo; Giedion, Ursula; Arbelaez, José Jesus; Bowser, Diana M.

2003-01-01

OBJECTIVE: To investigate the relation between decentralization and equity of resource allocation in Colombia and Chile. METHODS: The "decision space" approach and analysis of expenditures and utilization rates were used to provide a comparative analysis of decentralization of the health systems of Colombia and Chile. FINDINGS: Evidence from Colombia and Chile suggests that decentralization, under certain conditions and with some specific policy mechanisms, can improve equity of resource allocation. In these countries, equitable levels of per capita financial allocations at the municipal level were achieved through different forms of decentralization--the use of allocation formulae, adequate local funding choices and horizontal equity funds. Findings on equity of utilization of services were less consistent, but they did show that increased levels of funding were associated with increased utilization. This suggests that improved equity of funding over time might reduce inequities of service utilization. CONCLUSION: Decentralization can contribute to, or at least maintain, equitable allocation of health resources among municipalities of different incomes. PMID:12751417

1997 Federal Highway Cost Allocation Study. Summary Report

DOT National Transportation Integrated Search

1997-08-01

This is the first Federal Highway Cost Allocation Study (HCAS) since 1982. There are two key reasons for conducting this study. The first is to determine how changes in the Federal highway program and user fees which support that program have affecte...

How are population-based funding formulae for healthcare composed? A comparative analysis of seven models.

PubMed

Penno, Erin; Gauld, Robin; Audas, Rick

2013-11-08

Population-based funding formulae act as an important means of promoting equitable health funding structures. To evaluate how policy makers in different jurisdictions construct health funding formulae and build an understanding of contextual influences underpinning formula construction we carried out a comparative analysis of key components of funding formulae across seven high-income and predominantly publically financed health systems: New Zealand, England, Scotland, the Netherlands, the state of New South Wales in Australia, the Canadian province of Ontario, and the city of Stockholm, Sweden. Core components from each formula were summarised and key similarities and differences evaluated from a compositional perspective. We categorised approaches to constructing funding formulae under three main themes: identifying factors which predict differential need amongst populations; adjusting for cost factors outside of needs factors; and engaging in normative correction of allocations for 'unmet' need. We found significant congruence in the factors used to guide need and cost adjustments. However, there is considerable variation in interpretation and implementation of these factors. Despite broadly similar frameworks, there are distinct differences in the composition of the formulae across the seven health systems. Ultimately, the development of funding formulae is a dynamic process, subject to availability of data reflecting health needs, the influence of wider socio-political objectives and health system determinants.

Pediatric Patients with High Pulmonary Arterial Pressure in Congenital Heart Disease Have Increased Tracheal Diameters Measured by Computed Tomography.

PubMed

Ohashi, Nobuko; Imai, Hidekazu; Seino, Yutaka; Baba, Hiroshi

2017-12-06

Determination of the appropriate tracheal tube size using formulas based on age or height often is inaccurate in pediatric patients with congenital heart disease (CHD), particularly in those with high pulmonary arterial pressure (PAP). Here, the authors compared tracheal diameters between pediatric patients with CHD with high PAP and low PAP. Retrospective clinical study. Hospital. Pediatric patients, from birth to 6 months of age, requiring general anesthesia and tracheal intubation who underwent computed tomography were included. Patients with mean pulmonary artery pressure >25 mmHg were allocated to the high PAP group, and the remaining patients were allocated to the low PAP group. The primary outcome was the tracheal diameter at the cricoid cartilage level, and the secondary goal was to observe whether the size of the tracheal tube was appropriate compared with that obtained using predictable formulas based on age or height. The mean tracheal diameter was significantly larger in the high PAP group than in the low PAP group (p < 0.01). Pediatric patients with high PAP required a larger tracheal tube size than predicted by formulas based on age or height (p = 0.04 for age and height). Pediatric patients with high PAP had larger tracheal diameters than those with low PAP and required larger tracheal tubes compared with the size predicted using formulas based on age or height. Copyright © 2017 Elsevier Inc. All rights reserved.

A Report to the Iowa General Assembly on the Community College Funding Formula.

ERIC Educational Resources Information Center

Iowa State Dept. of Education, Des Moines. Div. of Community Colleges and Workforce Preparation.

Examining the methodology used to fund Iowa's 15 community colleges, this report reviews the history of the state's community colleges, highlights the strengths and weaknesses of the funding formula, and describes principles upon which sound funding should be based. Following a preface and executive summary, an introduction is provided to Iowa's…

Budgeting Approaches in Community Colleges

ERIC Educational Resources Information Center

Palmer, James C.

2014-01-01

Several budgeting approaches have been initiated as alternatives to the traditional, incremental process. These include formula budgeting; zero-base budgeting; planning, programming, and budgeting systems; and responsibility center budgeting. Each is premised on assumptions about how organizations might best make resource allocation decisions.…

78 FR 15374 - Notice of Formula Allocations and Program Requirements for Neighborhood Stabilization Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-11

... (or NSP) was established by the Housing and Economic Recovery Act of 2008 (HERA) (Pub. L. 110-289... background for the program, the program principles, and the objectives and outcomes of the NSP program. NSP...

26 CFR 1.1272-1 - Current inclusion of OID in income.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the amount of OID pursuant to the following formula: OIDshort = IP×(i/k)×f In which: OIDshort = The amount of OID allocable to the initial short accrual period IP = The issue price of the debt instrument i...

26 CFR 1.1272-1 - Current inclusion of OID in income.

Code of Federal Regulations, 2010 CFR

2010-04-01

... following formula: OIDshort = IP×(i/k)×f In which: OIDshort = The amount of OID allocable to the initial short accrual period IP = The issue price of the debt instrument i = The yield to maturity expressed as...

29 CFR 2520.104b-3 - Summary of material modifications to the plan and changes in the information required to be...

Code of Federal Regulations, 2010 CFR

2010-07-01

... future must disclose a summary of that modification within 210 days after the close of the plan year in... plan, including a reduction that occurs as a result of a change in formulas, methodologies or schedules...

24 CFR 92.508 - Recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-04-01

... participating jurisdiction must establish and maintain sufficient records to enable HUD to determine whether the... local government, or both) equal to or greater than the difference between its formula allocation and... used for homeownership housing, the procedures used for establishing 95 percent of the median purchase...

24 CFR 92.508 - Recordkeeping.

Code of Federal Regulations, 2011 CFR

2011-04-01

... participating jurisdiction must establish and maintain sufficient records to enable HUD to determine whether the... local government, or both) equal to or greater than the difference between its formula allocation and... used for homeownership housing, the procedures used for establishing 95 percent of the median purchase...

24 CFR 92.508 - Recordkeeping.

Code of Federal Regulations, 2012 CFR

2012-04-01

... participating jurisdiction must establish and maintain sufficient records to enable HUD to determine whether the... local government, or both) equal to or greater than the difference between its formula allocation and... used for homeownership housing, the procedures used for establishing 95 percent of the median purchase...

24 CFR 92.508 - Recordkeeping.

Code of Federal Regulations, 2013 CFR

2013-04-01

... participating jurisdiction must establish and maintain sufficient records to enable HUD to determine whether the... local government, or both) equal to or greater than the difference between its formula allocation and... used for homeownership housing, the procedures used for establishing 95 percent of the median purchase...

24 CFR 92.508 - Recordkeeping.

Code of Federal Regulations, 2014 CFR

2014-04-01

... and women's business enterprises have an equal opportunity to obtain or compete for contracts and... participating jurisdiction must establish and maintain sufficient records to enable HUD to determine whether the... local government, or both) equal to or greater than the difference between its formula allocation and...

The effects of the National School Lunch Program on education and health.

PubMed

Hinrichs, Peter

2010-01-01

This paper estimates the effects of participating in the National School Lunch Program in the middle of the 20th century on adult health outcomes and educational attainment. I utilize an instrumental variables strategy that exploits a change in the formula used by the federal government to allocate funding to the states. Identification is achieved by the fact that different birth cohorts were exposed to different degrees to the original formula and the new formula, along with the fact that the change of the formula affected states differentially by per capita income. Participation in the program as a child appears to have few long-run effects on health, but the effects on educational attainment are sizable. These results may suggest that subsidized lunches induced children to attend school but displaced food consumption from other sources. Alternatively, the program may have had short-run health effects that dissipated over time but that facilitated higher educational attainment.

Tax Base Composition and Family Income in Measuring School District Fiscal Capacity. Working Papers in Education Finance, Paper No. 12.

ERIC Educational Resources Information Center

Vincent, Phillip E.; Adams, E. Kathleen

The authors' review of several studies on school district fiscal response to state aid formulas precedes a summary of their research results from case studies of Colorado and Minnesota. The studies reviewed examined factors influencing district fiscal capacity and expenditure changes made in response to aid formulas, especially to…

77 FR 73965 - Allocation of Costs Under the Simplified Methods; Hearing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-12

... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 [REG-126770-06] RIN 1545-BG07 Allocation of Costs Under the Simplified Methods; Hearing AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of public hearing on notice proposed rulemaking. SUMMARY: This document provides notice of...

75 FR 10463 - Office of Insular Affairs; Allocation of Duty-Exemptions for Calendar Year 2010 for Watch...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... DEPARTMENT OF COMMERCE International Trade Administration DEPARTMENT OF THE INTERIOR Office of..., Department of Commerce; Office of Insular Affairs, Department of the Interior. ACTION: Notice. SUMMARY: This... Departments of the Interior and Commerce (``the Departments'') share responsibility for the allocation of duty...

76 FR 77900 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-15

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer Plans; Interest Assumptions for Valuing and Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: This final...

76 FR 13883 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer Plans; Interest Assumptions for Valuing and Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: This final...

78 FR 16401 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-15

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer Plans; Interest Assumptions for Valuing and Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: This final...

78 FR 35754 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer Plans; Interest Assumptions for Valuing and Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: This final...

77 FR 56770 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer Plans; Interest Assumptions for Valuing and Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: This final...

75 FR 33688 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer Plans; Interest Assumptions for Valuing and Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: Pension...

75 FR 12121 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer Plans; Interest Assumptions for Valuing and Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: Pension...

78 FR 56603 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-13

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single... Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: This final rule amends the Pension Benefit Guaranty Corporation's regulations on Benefits Payable in Terminated...

76 FR 34847 - Allocation of Assets in Single-Employer Plans; Benefits Payable in Terminated Single-Employer...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... PENSION BENEFIT GUARANTY CORPORATION 29 CFR Parts 4022 and 4044 Allocation of Assets in Single... Paying Benefits AGENCY: Pension Benefit Guaranty Corporation. ACTION: Final rule. SUMMARY: This final rule amends the Pension Benefit Guaranty Corporation's regulations on Benefits Payable in Terminated...

Estimated impacts of the 2010 census on the Texas transit funding formula.

DOT National Transportation Integrated Search

2010-09-01

Changes in the population and land area of urbanized areas in Texas will play a significant role in : determining the allocation of public transportation funds to service providers in Texas after Census 2010. : The purpose of this research report is ...

75 FR 33203 - Funding Formula for Grants to States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... as Social Security numbers, birth dates, and medical data. Docket: To read or download submissions or... Local Area Unemployment Statistics (LAUS), both of which are compiled by DOL's Bureau of Labor Statistics. Specifies how each State's basic JVSG allocation is calculated. Identifies the procedures...

78 FR 29771 - Notice of Formula Allocations and Program Requirements for Neighborhood Stabilization Programs 1...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-21

... impairments may access this number via TTY by calling the Federal Relay Service at 800-877-8339. FAX inquiries... and Consumer Protection Act of 2010 (Pub. L. 111-203, approved July 21, 2010) (Dodd-Frank Act) for the...

A data-driven allocation tool for in-kind resources distributed by a state health department.

PubMed

Peterson, Cora; Kegler, Scott R; Parker, Wende R; Sullivan, David

2016-10-02

The objective of this study was to leverage a state health department's operational data to allocate in-kind resources (children's car seats) to counties, with the proposition that need-based allocation could ultimately improve public health outcomes. This study used a retrospective analysis of administrative data on car seats distributed to counties statewide by the Georgia Department of Public Health and development of a need-based allocation tool (presented as interactive supplemental digital content, adaptable to other types of in-kind public health resources) that relies on current county-level injury and sociodemographic data. Car seat allocation using public health data and a need-based formula resulted in substantially different recommended allocations to individual counties compared to historic distribution. Results indicate that making an in-kind public health resource like car seats universally available results in a less equitable distribution of that resource compared to deliberate allocation according to public health need. Public health agencies can use local data to allocate in-kind resources consistent with health objectives; that is, in a manner offering the greatest potential health impact. Future analysis can determine whether the change to a more equitable allocation of resources is also more efficient, resulting in measurably improved public health outcomes.

WIC's promotion of infant formula in the United States

PubMed Central

Kent, George

2006-01-01

Background The United States' Special Supplemental Nutrition Program for Women, Infants and Children (WIC) distributes about half the infant formula used in the United States at no cost to the families. This is a matter of concern because it is known that feeding with infant formula results in worse health outcomes for infants than breastfeeding. Discussion The evidence that is available indicates that the WIC program has the effect of promoting the use of infant formula, thus placing infants at higher risk. Moreover, the program violates the widely accepted principles that have been set out in the International Code of Marketing of Breast-milk Substitutes and in the human right to adequate food. Summary There is no good reason for an agency of government to distribute large quantities of free infant formula. It is recommended that the large-scale distribution of free infant formula by the WIC program should be phased out. PMID:16722534

Case In Point: The Administrative Predicament of Special Education Funding.

ERIC Educational Resources Information Center

Moore-Brown, Barbra

2001-01-01

This article discusses factors that are creating fiscal stress in special education, including funding formulas which are inequitable, legal costs, limitations in funds allocated to hire instructional and administrative staff, costs for unending training needs, uncontrolled costs of nonpublic or private placements, specialized technology,…

A Note on Costing the Teaching Activity in Higher Education

ERIC Educational Resources Information Center

Birch, D. W.; And Others

1977-01-01

One method of calculating unit costs for the teaching function is explained. A formula is developed for allocating expenditures on the basis of a timetable analysis and tested on data from Lanchester Polytechnic and Loughborough University for the academic year 1972-73. (Author/LBH)

A Performance-Based Web Budget Tool

ERIC Educational Resources Information Center

Abou-Sayf, Frank K.; Lau, Wilson

2007-01-01

A web-based formula-driven tool has been developed for the purpose of performing two distinct academic department budgeting functions: allocation funding to the department, and budget management by the department. The tool's major features are discussed and its uses demonstrated. The tool's advantages are presented. (Contains 10 figures.)

24 CFR 92.61 - Program description.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Development HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.61 Program... occupied) and, for tenant assistance, number of households to be assisted; (3) A timetable for the... use other forms of investment not described in § 92.205(b), a description of the other forms of...

24 CFR 92.61 - Program description.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Development HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.61 Program... occupied) and, for tenant assistance, number of households to be assisted; (3) A timetable for the... use other forms of investment not described in § 92.205(b), a description of the other forms of...

24 CFR 92.65 - Funding sanctions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Funding sanctions. 92.65 Section 92.65 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.65 Funding sanctions...

24 CFR 92.65 - Funding sanctions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Funding sanctions. 92.65 Section 92.65 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.65 Funding sanctions...

24 CFR 92.65 - Funding sanctions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Funding sanctions. 92.65 Section 92.65 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.65 Funding sanctions...

24 CFR 92.65 - Funding sanctions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Funding sanctions. 92.65 Section 92.65 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.65 Funding sanctions...

24 CFR 92.65 - Funding sanctions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Funding sanctions. 92.65 Section 92.65 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM Allocation Formula Insular Areas Program § 92.65 Funding sanctions...

Education of the Handicapped Act Amendments of 1990, P.L. 101-476: A Summary. CRS Report for Congress.

ERIC Educational Resources Information Center

Aleman, Steven R.

This summary of the Education of the Handicapped Act Amendments of 1990, Public Law 101-476, identifies how these Amendments extend and expand special education research, demonstration, and training programs of the Individuals with Disabilities Education Act (IDEA). IDEA authorizes three state formula grant programs and several discretionary grant…

Effectiveness of Acupuncture and Electroacupuncture for Chronic Neck Pain: A Systematic Review and Meta-Analysis.

PubMed

Seo, See Yoon; Lee, Ki-Beom; Shin, Joon-Shik; Lee, Jinho; Kim, Me-Riong; Ha, In-Hyuk; Ko, Youme; Lee, Yoon Jae

2017-01-01

The aim of this systematic review was to assess evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture and electroacupuncture in patients with chronic neck pain. We searched nine databases including Chinese, Japanese and Korean databases through 30 July 2016. The participants were adults with chronic neck pain and were treated with acupuncture or electroacupuncture. Eligible trials were those with intervention groups receiving acupuncture and electroacupuncture with or without active control, and control groups receiving other conventional treatments such as physical therapy or medication. Outcomes included pain intensity, disability, quality of life (QoL) and adverse effects. For statistical pooling, the standardized mean difference (SMD) and its 95% confidence interval (CI) were calculated using a fixed-effects model. Sixteen RCTs were selected. The comparison of the sole acupuncture group and the active control group did not come out with a significant difference in pain (SMD 0.24, 95% CI [Formula: see text]0.27-0.75), disability (SMD 0.51, 95% CI [Formula: see text]0.01-1.02), or QoL (SMD [Formula: see text]0.37, 95% CI [Formula: see text]1.09-0.35), showing a similar effectiveness of acupuncture with active control. When acupuncture was added into the control group, the acupuncture add-on group showed significantly higher relief of pain in studies with unclear allocation concealment (SMD [Formula: see text]1.78, 95% CI [Formula: see text]2.08-[Formula: see text]1.48), but did not show significant relief of pain in studies with good allocation concealment (SMD [Formula: see text]0.07, 95% CI [Formula: see text]0.26-0.12). Significant relief of pain was observed when the sole electroacupuncture group was compared to the control group or electroacupuncture was added onto the active control group, but a lot of the results were evaluated to have low level of evidence, making it difficult to draw clear conclusions. In the result reporting adverse effects, no serious outcome of adverse event was confirmed. Acupuncture and conventional medicine for chronic neck pain have similar effectiveness on pain and disability when compared solely between the two of them. When acupuncture was added onto conventional treatment it relieved pain better, and electroacupuncture relieved pain even more. It is difficult to draw conclusion because the included studies have a high risk of bias and imprecision. Therefore better designed large-scale studies are needed in the future.

COMPARISON OF CHILDREN'S FOLLOW-ON INSTANT POWDERED COW'S MILK FORMULA, BUFFALO MILK FORMULA AND CHICKEN-BASED FORMULA ON ENAMEL MICROHARDNESS OF BOVINE TEETH IN VITRO.

PubMed

Vongsavan, Kadkao; Rirattanapong, Praphasri; Surarit, Rudee

2016-03-01

Dental caries are a major public health problem worldwide. The aim of this study was to compare the effects of children's follow-on instant powdered cow's milk formula, buffalo milk formula and a chicken-based formula on microhardness of bovine enamel with artificial caries-like lesions. Forty bovine teeth were each placed in acrylic blocks and the enamel surfaces were polished to create flat 5 x 5 millimeter surfaces. The teeth surfaces were then demineralized using 0.1M lactic acid (pH 4.5) to achieve an enamel microhardness of 35-65 Vickers Hardness Numbers (VHN). All specimens were then randomly allocated into one of 4 groups (n=10/group). For remineralization, each group was soaked in a different kind of milk formula for 2 hours at 37°C except group 1 which was a negative control (artificial saliva) group. Group 2 was soaked in Murrah™ buffalo milk formula (a positive control ), group 3 in S-26-Promil-Gold™ (cow's milk formula) and group 4 in a chicken-based formula (Siriraj Hospital, Mahidol University). The microhardness of the specimens was then measured again. Data were analyzed using a one-way ANOVA and paired t-test with a 95% confidence interval. After exposure to the formula, the mean VHN for each study group was significantly higher (paired t-test, p < 0.05) except for group 1 (p = 0.345). The mean VHN for the the Murrah™ buffalo milk formula, the chicken-based formula and the S-26-Promil-Gold™ formula group were not significantly different from each other (one-way ANOVA, p > 0.05). In conclusion, S-26-Promil-Gold™ follow-on cow milk formula, Murrah™ buffalo milk formula and the chicken-based formula all increased bovine enamel microhardness after soaking for 2 hours.

Cost Differentials in State Aid Programs in Selected States.

ERIC Educational Resources Information Center

Jordan, K. Forbis

This paper discusses the merits of cost differentials and weighted-pupil formulas as vehicles for allocating State school support funds to local school districts. The research conducted by the National Educational Finance Project to identify educational program expenditures and to develop cost differentials for each educational program in a…

75 FR 27056 - FTA Supplemental Fiscal Year 2010 Apportionments, Allocations, and Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... notice to apportion the full amount of FY 2010 formula funds. In addition, this Notice revises the Job Access and Reverse Commute (JARC) and Alternatives Analysis program carryover tables, Small Transit... projects under the Alternative Analysis program. FOR FURTHER INFORMATION CONTACT: For general information...

24 CFR 92.50 - Formula allocation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... per rental unit basis, that amount is capped at twice the national average. (3) To determine the... of funds calculation) exceed twice the national average, on a per rental unit basis, each amount that... previous fiscal year, are metropolitan cities, urban counties, or consortia approved under § 92.101; and...

24 CFR 92.50 - Formula allocation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... per rental unit basis, that amount is capped at twice the national average. (3) To determine the... of funds calculation) exceed twice the national average, on a per rental unit basis, each amount that... previous fiscal year, are metropolitan cities, urban counties, or consortia approved under § 92.101; and...

24 CFR 92.50 - Formula allocation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... per rental unit basis, that amount is capped at twice the national average. (3) To determine the... of funds calculation) exceed twice the national average, on a per rental unit basis, each amount that... previous fiscal year, are metropolitan cities, urban counties, or consortia approved under § 92.101; and...

24 CFR 92.50 - Formula allocation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... per rental unit basis, that amount is capped at twice the national average. (3) To determine the... of funds calculation) exceed twice the national average, on a per rental unit basis, each amount that... previous fiscal year, are metropolitan cities, urban counties, or consortia approved under § 92.101; and...

28 CFR 31.303 - Substantive requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... problem to allocate formula grant funds to programs designed for serious and violent juvenile offenders at... juvenile delinquents placed in a jail or a lockup for up to six hours from the time they enter a secure... time-phasing of common use nonresidential areas; and (2) Separate juvenile and adult programs...

28 CFR 31.303 - Substantive requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... problem to allocate formula grant funds to programs designed for serious and violent juvenile offenders at... juvenile delinquents placed in a jail or a lockup for up to six hours from the time they enter a secure... time-phasing of common use nonresidential areas; and (2) Separate juvenile and adult programs...

28 CFR 31.303 - Substantive requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... problem to allocate formula grant funds to programs designed for serious and violent juvenile offenders at... juvenile delinquents placed in a jail or a lockup for up to six hours from the time they enter a secure... time-phasing of common use nonresidential areas; and (2) Separate juvenile and adult programs...

75 FR 64322 - Notice of Formula Allocations and Program Requirements for Neighborhood Stabilization Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

... notice also notes statutory issues affecting program design and implementation. Note: This notice is... gave HUD broad waiver and alternative requirement authority, which HUD used in designing NSP program... activity produces housing, how the design of the activity will ensure continued affordability; v. How the...

Formula Feedback and Central Cities: The Case of the Comprehensive Employment and Training Act.

ERIC Educational Resources Information Center

Jones, E. Terrence; Phares, Donald

1978-01-01

This study critically examines the measurement of the Comprehesive Employment and Training Act's key allocation variable, unemployment. The analysis indicates (1) unemployment rates are higher than government estimates and (2) methods used to measure state and local umemployment have several weaknesses. (Author/RLV)

Population-based funding formulae cultural coefficients: seeking a more equitable distribution of health dollars in New Zealand.

PubMed

Mellsop, Graham; McClintock, Kahu; Dutu, Gaelle

2007-03-23

Evidence and argument for the allocation of funds to forensic psychiatric services to take account of the ethnic disparities in the use of the Justice System is presented. This would reflect the reality of the distribution of Service demand.

Missouri Comprehensive Outdoor Recreation Plan: Executive Summary.

ERIC Educational Resources Information Center

Missouri State Inter-Agency for Outdoor Recreation, Jefferson.

The document is a summary of the Missouri State Comprehensive Outdoor Recreation Plan, which was designed to provide guidelines for allocation of resources for needed recreation facilities. The plan identifies the present and future needs for outdoor recreation and recommends ways of meeting these needs. This 1967 document provides a brief history…

75 FR 76975 - 2015 Resource Pool-Sierra Nevada Region

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

...The Western Area Power Administration (Western), a Federal power marketing administration of DOE, announces the Final 2015 Resource Pool allocations pursuant to its 2004 Power Marketing Plan (Marketing Plan) for the Sierra Nevada Customer Service Region (SNR). This notice includes a summary of the comments received on Western's proposed 2015 Resource Pool allocations and Western's responses.

Federal Aid to Public Education: Who Benefits?

ERIC Educational Resources Information Center

Berke, Joel S.; And Others

A summary report of an 18-month study of patterns of allocation of federal aid to education is presented. The scope of the study covers two areas: (1) The Fiscal Context of Urban Education, and (2) The Pattern of Allocation of Federal Aid to Education. The data, analyses, and conclusions of the report are presented in three chapters. Chapter I…

Infant Formula and Fluorosis

MedlinePlus

... and School-Linked Dental Sealant Programs Coordinate Community Water Fluoridation Programs Targeted Clinical Preventive Services & Health Systems Changes State Oral Health Plans Research & Publications Oral Health In America: Summary of the ...

Towards Decentralized and Goal-Oriented Models of Institutional Resource Allocation: The Spanish Case

ERIC Educational Resources Information Center

Lopez, Maria Jose Gonzalez

2006-01-01

The search for more flexibility in financial management of public universities demands adjustments in budgeting strategies. International studies on this topic recommend wider financial autonomy for management units, the use of budgeting models based on performance, the implementation of formula systems for the determination of financial needs of…

Don't Leave Accountability behind: A Call for ESEA Reauthorization

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

As 2010 unfolds, Americans should feel encouraged by federal, state, and local efforts to transform education policies that boost student performance. In the midst of a recession, rather than merely allocating billions of American Recovery and Reinvestment Act (ARRA) dollars by formula to the states with no strings attached, the Obama…

75 FR 68615 - Notice of Submission of Proposed Information Collection to OMB; Public Housing Capital Fund...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

... below has been submitted to the Office of Management and Budget (OMB) for review, as required by the..., development, financing, and management improvements. The funds are allocated based on a complex formula. The... any Mixed-Finance and Capital Fund Financing transactions. Respondents include the approximately 3,200...

Using Simulations in Linked Courses to Foster Student Understanding of Complex Political Institutions

ERIC Educational Resources Information Center

Williams, Michelle Hale

2015-01-01

Political institutions provide basic building blocks for understanding and comparing political systems. Yet, students often struggle to understand the implications of institutional choice, such as electoral system rules, especially when the formulas and calculations used to determine seat allocation can be multilevel and complex. This study brings…

State Strategies for Financing Career and Technical Education

ERIC Educational Resources Information Center

Foster, Laura Rasmussen; Klein, Steve; Elliott, Barbara

2014-01-01

The "Carl D. Perkins Career and Technical Education Act of 2006" ("Perkins IV" or "Act") authorizes federal funding for career and technical education (CTE) and specifies a formula for distributing those funds. Allocations at the secondary level are based on the number of youths ages 5-17 who reside within a local…

26 CFR 1.168(i)-0 - Table of contents for the general asset account rules.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Source of ordinary income, gain, or loss. (i) Source determined by allocation and apportionment of depreciation allowed. (ii) Formula for determining foreign source income, gain, or loss. (3) Section 904(d... disposed or converted asset. (k) Effect of adjustments on prior dispositions. (l) Election. (1) Irrevocable...

26 CFR 1.168(i)-0 - Table of contents for the general asset account rules.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Source of ordinary income, gain, or loss. (i) Source determined by allocation and apportionment of depreciation allowed. (ii) Formula for determining foreign source income, gain, or loss. (3) Section 904(d... disposed or converted asset. (k) Effect of adjustments on prior dispositions. (l) Election. (1) Irrevocable...

26 CFR 1.168(i)-0 - Table of contents for the general asset account rules.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) Source of ordinary income, gain, or loss. (i) Source determined by allocation and apportionment of depreciation allowed. (ii) Formula for determining foreign source income, gain, or loss. (3) Section 904(d... disposed or converted asset. (k) Effect of adjustments on prior dispositions. (l) Election. (1) Irrevocable...

77 FR 34262 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Western Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

.... 111213751-2102-02] RIN 0648-XC061 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch.... ACTION: Temporary rule; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in... allocation of Pacific ocean perch in this area allocated to vessels participating in the BSAI trawl limited...

75 FR 69600 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Eastern Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

.... 0910131363-0087-02] RIN 0648-XA034 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch.... ACTION: Temporary rule; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in... allocation of Pacific ocean perch in this area allocated to vessels participating in the BSAI trawl limited...

76 FR 43933 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Western Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

.... 101126521-0640-02] RIN 0648-XA589 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch.... ACTION: Temporary rule; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in... allocation of Pacific ocean perch in this area allocated to vessels participating in the BSAI trawl limited...

76 FR 65972 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Eastern Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-25

.... 101126521-0640-02] RIN 0648-XA782 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch.... ACTION: Temporary rule; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in... allocation of Pacific ocean perch in this area allocated to vessels participating in the BSAI trawl limited...

75 FR 69601 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Central Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

.... 0910131363-0087-02] RIN 0648-XA035 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch.... ACTION: Temporary rule; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in... allocation of Pacific ocean perch in this area allocated to vessels participating in the BSAI trawl limited...

77 FR 39440 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Central Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

.... 111213751-2102-02] RIN 0648-XC085 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch.... ACTION: Temporary rule; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in... allocation of Pacific ocean perch in this area allocated to vessels participating in the BSAI trawl limited...

75 FR 69601 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Western Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

.... 0910131363-0087-02] RIN 0648-XA036 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch.... ACTION: Temporary rule; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in... allocation of Pacific ocean perch in this area allocated to vessels participating in the BSAI trawl limited...

Ada (Tradename) Compiler Validation Summary Report. Concurrent Computer Corporation C3 Ada, Version R00-00.00. Concurrent Computer Corporation Series 3200.

DTIC Science & Technology

1986-06-11

been specified, then the amount specified is returned. Otherwise the current amount allocated is returned. T’STORAGESIZE for task types or objects is...hrs DURATION’LAST 131071.99993896484375 36 hrs F.A Address Clauses Address clauses are implemented for objects. No storage is allocated for objects...it is ignored. at Allocation . An integer in the range 1..2,147,483,647. For CONTIGUOUS files, it specifies the number of 256 byte sectors. For ITAM

Optimal allocation of bulk water supplies to competing use sectors based on economic criterion - An application to the Chao Phraya River Basin, Thailand

NASA Astrophysics Data System (ADS)

Divakar, L.; Babel, M. S.; Perret, S. R.; Gupta, A. Das

2011-04-01

SummaryThe study develops a model for optimal bulk allocations of limited available water based on an economic criterion to competing use sectors such as agriculture, domestic, industry and hydropower. The model comprises a reservoir operation module (ROM) and a water allocation module (WAM). ROM determines the amount of water available for allocation, which is used as an input to WAM with an objective function to maximize the net economic benefits of bulk allocations to different use sectors. The total net benefit functions for agriculture and hydropower sectors and the marginal net benefit from domestic and industrial sectors are established and are categorically taken as fixed in the present study. The developed model is applied to the Chao Phraya basin in Thailand. The case study results indicate that the WAM can improve net economic returns compared to the current water allocation practices.

Variances and uncertainties of the sample laboratory-to-laboratory variance (S(L)2) and standard deviation (S(L)) associated with an interlaboratory study.

PubMed

McClure, Foster D; Lee, Jung K

2012-01-01

The validation process for an analytical method usually employs an interlaboratory study conducted as a balanced completely randomized model involving a specified number of randomly chosen laboratories, each analyzing a specified number of randomly allocated replicates. For such studies, formulas to obtain approximate unbiased estimates of the variance and uncertainty of the sample laboratory-to-laboratory (lab-to-lab) STD (S(L)) have been developed primarily to account for the uncertainty of S(L) when there is a need to develop an uncertainty budget that includes the uncertainty of S(L). For the sake of completeness on this topic, formulas to estimate the variance and uncertainty of the sample lab-to-lab variance (S(L)2) were also developed. In some cases, it was necessary to derive the formulas based on an approximate distribution for S(L)2.

A person based formula for allocating commissioning funds to general practices in England: development of a statistical model.

PubMed

Dixon, Jennifer; Smith, Peter; Gravelle, Hugh; Martin, Steve; Bardsley, Martin; Rice, Nigel; Georghiou, Theo; Dusheiko, Mark; Billings, John; Lorenzo, Michael De; Sanderson, Colin

2011-11-22

To develop a formula for allocating resources for commissioning hospital care to all general practices in England based on the health needs of the people registered in each practice Multivariate prospective statistical models were developed in which routinely collected electronic information from 2005-6 and 2006-7 on individuals and the areas in which they lived was used to predict their costs of hospital care in the next year, 2007-8. Data on individuals included all diagnoses recorded at any inpatient admission. Models were developed on a random sample of 5 million people and validated on a second random sample of 5 million people and a third sample of 5 million people drawn from a random sample of practices. All general practices in England as of 1 April 2007. All NHS inpatient admissions and outpatient attendances for individuals registered with a general practice on that date. All individuals registered with a general practice in England at 1 April 2007. Power of the statistical models to predict the costs of the individual patient or each practice's registered population for 2007-8 tested with a range of metrics (R(2) reported here). Comparisons of predicted costs in 2007-8 with actual costs incurred in the same year were calculated by individual and by practice. Models including person level information (age, sex, and ICD-10 codes diagnostic recorded) and a range of area level information (such as socioeconomic deprivation and supply of health facilities) were most predictive of costs. After accounting for person level variables, area level variables added little explanatory power. The best models for resource allocation could predict upwards of 77% of the variation in costs at practice level, and about 12% at the person level. With these models, the predicted costs of about a third of practices would exceed or undershoot the actual costs by 10% or more. Smaller practices were more likely to be in these groups. A model was developed that performed well by international standards, and could be used for allocations to practices for commissioning. The best formulas, however, could predict only about 12% of the variation in next year's costs of most inpatient and outpatient NHS care for each individual. Person-based diagnostic data significantly added to the predictive power of the models.

State Compensatory Education in New Jersey: The Allocation Formula. Series I.

ERIC Educational Resources Information Center

Thomas, Earl Preston

While it is understood that state compensatory education funds will probably do little to close the gap in public school expenditure levels between wealthy and poor New Jersey districts, it is still important that the educational consumer and the interested observer understand how the system works. Compensatory education funds are the source of…

A Fifty-State Survey of School Finance Policies and Programs: An Overview

ERIC Educational Resources Information Center

Verstegen, Deborah A.; Jordan, Teresa S.

2009-01-01

This overview provides a synthesis of a comprehensive survey of school finance programs in the 50 states conducted in 2006-07. Information was provided by chief state school finance officers or persons with expertise in a state's public school funding-allocation system. Brief descriptions of the major Pre-K-12 funding formulae, district-based…

77 FR 22061 - FTA Section 5307 Urbanized Area Formula Program: Allocation of Funding Caps for Treating Fuel and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... Propulsion as a Capital Maintenance Expense AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice... for the propulsion of electrical vehicles, as a capital maintenance item for grants made in FY 2012... utility costs for the propulsion of electrical vehicles, as a capital maintenance item for grants made in...

Examining the Effects of School-Level Variables on Elementary School Students' Academic Achievement: The Use of Structural Equation Modeling

ERIC Educational Resources Information Center

Della Sala, Matthew Robert

2014-01-01

School finance scholars have called for the alignment of accountability policies with state finance formulae to allocate resources toward student learning goals (Adams, 2008; Ryan, 2008; Superfine, 2009; Verstegen, 2002). With the presence of accountability policies that focus on improving students' academic achievement, state finance systems must…

Essays in the Political Economy of Higher Education Funding

ERIC Educational Resources Information Center

Compton, Benjamin Hasty

2011-01-01

This dissertation addresses the consequences of political influence on state higher education funding at the committee level. The State of South Carolina has a long history of using a formula to determine the appropriate amount of funding that is to be allocated to its colleges and universities. I use the funding level implied by the South…

78 FR 45903 - Native American Housing Assistance and Self-Determination Act of 1996: Negotiated Rulemaking...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

... Rulemaking Committee. The committee will negotiate a proposed rule to revise the allocation formula used under the Indian Housing Block Grant (IHBG) Program. In addition, this notice announces a two-day first...:30 a.m., and adjourn at approximately 5 p.m. ADDRESSES: The meeting will take place at the Grand...

77 FR 6137 - Notice of Proposed Information Collection for Public Comment: Data Collection for Full Housing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

... to use this information to develop a new administrative fee allocation formula for the HCV program... program effectively without the benefit of economies of scale that apply to larger programs. The results... costs can be explained by PHA, participant, and market characteristics. The results of the model will be...

Forest control and regulation ... a comparison of traditional methods and alternatives

Treesearch

LeRoy C. Hennes; Michael J. Irving; Daniel I. Navon

1971-01-01

Two traditional techniques of forest control and regulation-formulas and area-volume check-are compared to linear programing, as used in a new computerized planning system called Timber Resource Allocation Method ( Timber RAM). Inventory data from a National Forest in California illustrate how each technique is used. The traditional methods are simpler to apply and...

The Pros and Cons of Existing Formula Financing Systems and a Suggested New Approach.

ERIC Educational Resources Information Center

Van Wijk, Alfons P.; Levine, Jack B.

Because the Colleges of Applied Arts and Technology (CAATS) of Ontario are largely dependent on the Ontario Government for financial support, it is important to justify their level of expenditure, and prove that allotted public funds are effectively and efficiently managed. After a brief discussion of the existing resource allocation process in…

77 FR 57544 - Native American Housing Assistance and Self-Determination Reauthorization Act of 1996: Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-18

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT 24 CFR Part 1000 [Docket No. FR-5650-N-02] Native...) program. The regulations governing the IHBG formula allocation are codified in subpart D of part 1000 of... negotiated rulemaking required by Section 106 of NAHASDA and program regulations found at 24 CFR 1000.306...

A Northern Territory Approach to Quantifying "Access Disadvantage" to Educational Services in Remote and Rural Australia.

ERIC Educational Resources Information Center

Griffith, D. A.

The Griffith Service Access Frame (GSAF) is a model used for quantifying the access disadvantage to educational services of remote and rural areas in Australia. The model was specifically developed to assist policymakers and administrators in allocating resources. The problem with the current funding formula used by the Australian federal…

20 CFR 667.130 - How are WIA title I formula funds allocated to local workforce investment areas?

Code of Federal Regulations, 2010 CFR

2010-04-01

... section) relating to: (A) Excess poverty in urban, rural and suburban local areas; and (B) Excess... the factors described in paragraph (c)(1) of this section) relating to: (A) Excess youth poverty in urban, rural and suburban local areas; and (B) Excess unemployment above the State average in urban...

Mediation analysis with time varying exposures and mediators

PubMed Central

VanderWeele, Tyler J.; Tchetgen Tchetgen, Eric J.

2016-01-01

Summary In this paper we consider causal mediation analysis when exposures and mediators vary over time. We give non-parametric identification results, discuss parametric implementation, and also provide a weighting approach to direct and indirect effects based on combining the results of two marginal structural models. We also discuss how our results give rise to a causal interpretation of the effect estimates produced from longitudinal structural equation models. When there are time-varying confounders affected by prior exposure and mediator, natural direct and indirect effects are not identified. However, we define a randomized interventional analogue of natural direct and indirect effects that are identified in this setting. The formula that identifies these effects we refer to as the “mediational g-formula.” When there is no mediation, the mediational g-formula reduces to Robins’ regular g-formula for longitudinal data. When there are no time-varying confounders affected by prior exposure and mediator values, then the mediational g-formula reduces to a longitudinal version of Pearl’s mediation formula. However, the mediational g-formula itself can accommodate both mediation and time-varying confounders and constitutes a general approach to mediation analysis with time-varying exposures and mediators. PMID:28824285

Genetic parameters and expected responses to selection for components of feed efficiency in a Duroc pig line.

PubMed

Sánchez, Juan P; Ragab, Mohamed; Quintanilla, Raquel; Rothschild, Max F; Piles, Miriam

2017-12-01

Improving feed efficiency ([Formula: see text]) is a key factor for any pig breeding company. Although this can be achieved by selection on an index of multi-trait best linear unbiased prediction of breeding values with optimal economic weights, considering deviations of feed intake from actual needs ([Formula: see text]) should be of value for further research on biological aspects of [Formula: see text]. Here, we present a random regression model that extends the classical definition of [Formula: see text] by including animal-specific needs in the model. Using this model, we explore the genetic determinism of several [Formula: see text] components: use of feed for growth ([Formula: see text]), use of feed for backfat deposition ([Formula: see text]), use of feed for maintenance ([Formula: see text]), and unspecific efficiency in the use of feed ([Formula: see text]). Expected response to alternative selection indexes involving different components is also studied. Based on goodness-of-fit to the available feed intake ([Formula: see text]) data, the model that assumes individual (genetic and permanent) variation in the use of feed for maintenance, [Formula: see text] and [Formula: see text] showed the best performance. Joint individual variation in feed allocation to maintenance, growth and backfat deposition comprised 37% of the individual variation of [Formula: see text]. The estimated heritabilities of [Formula: see text] using the model that accounts for animal-specific needs and the traditional [Formula: see text] model were 0.12 and 0.18, respectively. The estimated heritabilities for the regression coefficients were 0.44, 0.39 and 0.55 for [Formula: see text], [Formula: see text] and [Formula: see text], respectively. Estimates of genetic correlations of [Formula: see text] were positive with amount of feed used for [Formula: see text] and [Formula: see text] but negative for [Formula: see text]. Expected response in overall efficiency, reducing [Formula: see text] without altering performance, was 2.5% higher when the model assumed animal-specific needs than when the traditional definition of [Formula: see text] was considered. Expected response in overall efficiency, by reducing [Formula: see text] without altering performance, is slightly better with a model that assumes animal-specific needs instead of batch-specific needs to correct [Formula: see text]. The relatively small difference between the traditional [Formula: see text] model and our model is due to random intercepts (unspecific use of feed) accounting for the majority of variability in [Formula: see text]. Overall, a model that accounts for animal-specific needs for [Formula: see text], [Formula: see text] and [Formula: see text] is statistically superior and allows for the possibility to act differentially on [Formula: see text] components.

The Ratio of Docosahexaenoic Acid and Arachidonic Acid in Infant Formula Influences the Fatty Acid Composition of the Erythrocyte Membrane in Low-Birth-Weight Infants.

PubMed

Kitamura, Tomohiro; Kitamura, Yohei; Hamano, Hirokazu; Shoji, Hiromichi; Shimizu, Takashi; Shimizu, Toshiaki

2016-01-01

The arachidonic acid (ARA) and docosahexaenoic acid (DHA) contents in the infant formula influence on the growth and development of low-birth-weight infants (LBWI). In Japan, many infant formulas are fortified only with DHA. We investigated the safety and efficacy of an infant formula (H2025A) fortified with DHA and ARA (DHA/ARA ratio of 2:1, the same as that in Japanese breast milk). In this randomized double-blind trial, 35 LBWI were randomly allocated to 2 groups fed with H2025A or an infant formula fortified only with DHA (control formula) after discharge from the NICU. The duration of this study was one month, and the growth and fatty acid composition of the erythrocyte membrane were compared between the 2 groups. No difference was found in the body weight gain, height gain and head circumstance gain development between the 2 groups, and no adverse event occurred in both groups. The ARA content of the erythrocyte membrane after feeding for 1 month was significantly higher in the H2025A group than in the control group. On analysis adjusted with the breast-fed ratio, the ARA and DHA contents were significantly higher in the H2025A group. It was suggested that H2025A significantly increased the ARA and DHA contents of the erythrocyte membrane of LBWI compared to the contents of the control formula. © 2016 S. Karger AG, Basel.

Do Schools in Rural and Nonrural Districts Allocate Resources Differently? An Analysis of Spending and Staffing Patterns in the West Region States. Summary. Issues & Answers. REL 2011-No. 099

ERIC Educational Resources Information Center

Levin, Jesse; Manship, Karen; Chambers, Jay; Johnson, Jerry; Blankenship, Charles

2011-01-01

This report presents the first detailed comparison of resource allocation between rural and nonrural districts in the West Region. Three regional characteristics often associated with rural districts were chosen for the analysis: district enrollment, student population density within a district (students per square mile), and drive time from the…

24 CFR 1000.340 - What if an Indian tribe is allocated less funding under the IHBG Formula than it received in...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false What if an Indian tribe is... subsidy and modernization? 1000.340 Section 1000.340 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING...

24 CFR 1000.340 - What if an Indian tribe is allocated less funding under the IHBG Formula than it received in...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false What if an Indian tribe is... subsidy and modernization? 1000.340 Section 1000.340 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING...

24 CFR 1000.340 - What if an Indian tribe is allocated less funding under the IHBG Formula than it received in...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false What if an Indian tribe is... subsidy and modernization? 1000.340 Section 1000.340 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING...

24 CFR 1000.340 - What if an Indian tribe is allocated less funding under the IHBG Formula than it received in...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false What if an Indian tribe is... subsidy and modernization? 1000.340 Section 1000.340 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING...

24 CFR 1000.340 - What if an Indian tribe is allocated less funding under the IHBG Formula than it received in...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false What if an Indian tribe is... subsidy and modernization? 1000.340 Section 1000.340 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING...

24 CFR 1000.327 - What is the order of preference for allocating the IHBG formula needs data for Indian tribes in...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false What is the order of preference for... unique circumstances in Alaska? 1000.327 Section 1000.327 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN...

24 CFR 1000.302 - What are the definitions applicable for the IHBG formula?

Code of Federal Regulations, 2012 CFR

2012-04-01

... average for AEL. Date of Full Availability (DOFA) means the last day of the month in which substantially.... The “FMR factor” is the relative difference between a local area FMR and the national weighted average... be able to receive an allocation for up to three times its tribal enrollment if the Indian and Alaska...

24 CFR 1000.302 - What are the definitions applicable for the IHBG formula?

Code of Federal Regulations, 2013 CFR

2013-04-01

... average for AEL. Date of Full Availability (DOFA) means the last day of the month in which substantially.... The “FMR factor” is the relative difference between a local area FMR and the national weighted average... be able to receive an allocation for up to three times its tribal enrollment if the Indian and Alaska...

24 CFR 1000.302 - What are the definitions applicable for the IHBG formula?

Code of Federal Regulations, 2011 CFR

2011-04-01

... average for AEL. Date of Full Availability (DOFA) means the last day of the month in which substantially.... The “FMR factor” is the relative difference between a local area FMR and the national weighted average... be able to receive an allocation for up to three times its tribal enrollment if the Indian and Alaska...

24 CFR 1000.302 - What are the definitions applicable for the IHBG formula?

Code of Federal Regulations, 2014 CFR

2014-04-01

... average for AEL. Date of Full Availability (DOFA) means the last day of the month in which substantially.... The “FMR factor” is the relative difference between a local area FMR and the national weighted average... be able to receive an allocation for up to three times its tribal enrollment if the Indian and Alaska...

Implementing LCFF: Early Lessons from the Field. Policy and Practice Brief

ERIC Educational Resources Information Center

Knudson, Joel

2014-01-01

The Local Control Funding Formula (LCFF) represents a fundamental transformation of the way California allocates state funds to school districts and the ways the state expects districts to make decisions about (and report on) the use of these funds. This is the first in a series of short briefs that aims to capture some key themes emerging from…

Analysis of New York City's 2008-09 Approved Contract for Excellence Allocations

ERIC Educational Resources Information Center

Campaign for Fiscal Equity, Inc., 2009

2009-01-01

In April 2007, the New York State Legislature with the leadership of the Governor passed historic education legislation that provided for a multi-year infusion of new school funding; the creation of a clear cut system of accountability for new funds distributed under the legislation; and a fair and simple funding formula, known as Foundation Aid.…

Funding Students, Not Units: Moving Alabama from a Regressive Public School Funding State to a Progressive Public School Funding State

ERIC Educational Resources Information Center

Larkin, Brittany

2016-01-01

Two independent studies conducted by Baker, Sciarra, and Farrie (2015) and Augenblick, Palaich and Associates (2015) reveal Alabama's public school funding mechanism to be regressive and inequitable. The recommendation from both of these studies is to develop a funding formula including per pupil-based allocation and supplemental categorical…

The Perceived Challenges and Experiences That Alternative High School Administrators and Low-Income Single Mothers Encounter Regarding Increased Parental Involvement

ERIC Educational Resources Information Center

Abbott, Zenda Mitchell

2017-01-01

California's Local Control Funding Formula (LCFF) allocates funds to public schools based on demographics, including low-income, English language learners, foster youth, and students deemed at risk. One of the priorities outlined in the Local Control Accountability Plan (LCAP), a planning guide required by school districts and county…

Grounding Research in Reality: Fiscal Equity and K-12 Funding in Illinois. Policy Research: IERC 2008-3

ERIC Educational Resources Information Center

Mullin, Christopher M.; Brown, Kathleen Sullivan

2008-01-01

The purpose of this study was to replicate both The Education Trust's "The Funding Gap" and D. Verstegen and L. Driscoll's "The Illinois Dilemma" studies published in 2008 utilizing the actual allocations to districts resulting from the fiscal policy mechanism (funding formula) in Illinois for the 2004-2005 school year to…

Master standard data quantity food production code. Macro elements for synthesizing production labor time.

PubMed

Matthews, M E; Waldvogel, C F; Mahaffey, M J; Zemel, P C

1978-06-01

Preparation procedures of standardized quantity formulas were analyzed for similarities and differences in production activities, and three entrée classifications were developed, based on these activities. Two formulas from each classification were selected, preparation procedures were divided into elements of production, and the MSD Quantity Food Production Code was applied. Macro elements not included in the existing Code were simulated, coded, assigned associated Time Measurement Units, and added to the MSD Quantity Food Production Code. Repeated occurrence of similar elements within production methods indicated that macro elements could be synthesized for use within one or more entrée classifications. Basic elements were grouped, simulated, and macro elements were derived. Macro elements were applied in the simulated production of 100 portions of each entrée formula. Total production time for each formula and average production time for each entrée classification were calculated. Application of macro elements indicated that this method of predetermining production time was feasible and could be adapted by quantity foodservice managers as a decision technique used to evaluate menu mix, production personnel schedules, and allocation of equipment usage. These macro elements could serve as a basis for further development and refinement of other macro elements which could be applied to a variety of menu item formulas.

Justice and the allocation of healthcare resources: should indirect, non-health effects count?

PubMed

Lippert-Rasmussen, Kasper; Lauridsen, Sigurd

2010-08-01

Alternative allocations of a fixed bundle of healthcare resources often involve significantly different indirect, non-health effects. The question arises whether these effects must figure in accounts of the conditions under which a distribution of healthcare resources is morally justifiable. In this article we defend a Scanlonian, affirmative answer to this question: healthcare resource managers should sometimes select an allocation which has worse direct, health-related effects but better indirect, nonhealth effects; they should do this when the interests served by such a policy are more urgent than the healthcare interests better served by an alternative allocation. We note that there is a prima facie case for the claim that such benefits (and costs) are relevant--i.e. they are real benefits, and in other contexts our decisions can permissibly be guided by them. We then proceed to rebut three lines of argument that might be thought to defeat this prima facie case: they appeal to fairness, the Kantian Formula of Humanity as an End in Itself, and the equal moral worth of persons, respectively.

Derivation of a needs based capitation formula for allocating prescribing budgets to health authorities and primary care groups in England: regression analysis

PubMed Central

Rice, Nigel; Dixon, Paul; Lloyd, David C E F; Roberts, David

2000-01-01

Objective To develop a weighted capitation formula for setting target allocations for prescribing expenditures for health authorities and primary care groups in England. Design Regression analysis relating prescribing costs to the demographic, morbidity, and mortality composition of practice lists. Setting 8500 general practices in England. Subjects Data from the 1991 census were attributed to practice lists on the basis of the place of residence of the practice population. Main outcome measures Variation in age, sex, and temporary resident originated prescribing units (ASTRO(97)-PUs) adjusted net ingredient cost of general practices in England for 1997-8 modelled for the impact of health and social needs after controlling for differences in supply. Results A needs gradient based on the four variables: permanent sickness, percentage of dependants in no carer households, percentage of students, and percentage of births on practice lists. These, together with supply characteristics, explained 41% of variation in prescribing costs per ASTRO(97)-PU adjusted capita across practices. The latter alone explained about 35% of variation in total costs per head across practices. Conclusions The model has good statistical specification and contains intuitively plausible needs drivers of prescribing expenditure. Together with adjustments made for differences in ASTRO(97)-PUs the model is capable of explaining 62% (35%+0.65% (41%)) of variation in prescribing expenditure at practice level. The results of the study have formed the basis for setting target budgets for 1999-2000 allocations for prescribing expenditure for health authorities and primary care groups. PMID:10650026

Appraisal of formulas for stresses in bilayered dental ceramics subjected to biaxial moment loading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsueh, Chun-Hway; Thompson, G. A.

Summary - Objectives: The purpose of this study was to compare three existing sets of formulas predicting stresses in a thin circular plate subjected to biaxial moment loading, such that limitations for each set of formulas could be understood. These formulas include American Society for Testing and Materials (ASTM) formulas for monolayered plates, Roark's formulas for bilayered plates, and Hsueh et al.'s formulas for multilayered plates. Methods: The three sets of formulas were summarized and appraised. Biaxial moment loading is generally achieved using biaxial flexure tests, and the plate is placed on a support ring and loaded in the centralmore » region. While both ASTM and Hsueh et al.'s formulas predict stresses through the thickness of the plate, Roark's formulas predict stresses only on the top and the bottom surfaces of the plate. Also, a simply supported plate at its edge is considered in Roark's formulas. We modified Roark's formulas to include the overhang region of the plate to more closely simulate the actual loading configuration. Then, the accuracy of formulas was examined by comparing with finite element results of monolayered and bilayered plates subjected to ring-on-ring loading. Results: Monolayer is a special case of bilayer, and both monolayer and bilayer are special cases of multilayer. For monolayered plates, ASTM and Hsueh et al.'s formulas are identical, and both are in excellent agreement with finite element results. For bilayered plates, Hsueh et al.'s formulas are in excellent agreement with finite element results. For both monolayered and bilayered plates, Roark's formulas deviate from finite element results while the modified Roark's formulas are accurate. Conclusions: Roark's formulas for evaluating the biaxial strength of bilayered dental ceramics will result in errors in predicted stresses which depend on the size of the overhang region of the plate in the actual loading configuration. Also, Roark's formulas are limited to predicting stresses on the top and the bottom surfaces of the plate. On the other hand, Hsueh et al.'s formulas are for multilayered plates and predict stresses through the plate thickness.« less

Using Quantitative Data in World Bank Per-Student Funding Reform Projects: Data, Designs and Dilemmas in Transition Countries

ERIC Educational Resources Information Center

Levacic, Rosalind

2014-01-01

Since the late 1980s, education systems have increasingly moved to allocating funding for general education by means of a per-student formula. The trend started with developed economies and moved to transition and developing economies, where the World Bank has promoted the adoption of per-student funding (PSF). But promoting a particular reform,…

Association between funding source, methodological quality and research outcomes in randomized controlled trials of synbiotics, probiotics and prebiotics added to infant formula: A Systematic Review

PubMed Central

2013-01-01

Background There is little or no information available on the impact of funding by the food industry on trial outcomes and methodological quality of synbiotics, probiotics and prebiotics research in infants. The objective of this study was to compare the methodological quality, outcomes of food industry sponsored trials versus non industry sponsored trials, with regards to supplementation of synbiotics, probiotics and prebiotics in infant formula. Methods A comprehensive search was conducted to identify published and unpublished randomized clinical trials (RCTs). Cochrane methodology was used to assess the risk of bias of included RCTs in the following domains: 1) sequence generation; 2) allocation concealment; 3) blinding; 4) incomplete outcome data; 5) selective outcome reporting; and 6) other bias. Clinical outcomes and authors’ conclusions were reported in frequencies and percentages. The association between source of funding, risk of bias, clinical outcomes and conclusions were assessed using Pearson’s Chi-square test and the Fisher’s exact test. A p-value < 0.05 was statistically significant. Results Sixty seven completed and 3 on-going RCTs were included. Forty (59.7%) were funded by food industry, 11 (16.4%) by non-industry entities and 16 (23.9%) did not specify source of funding. Several risk of bias domains, especially sequence generation, allocation concealment and blinding, were not adequately reported. There was no significant association between the source of funding and sequence generation, allocation concealment, blinding and selective reporting, majority of reported clinical outcomes or authors’ conclusions. On the other hand, source of funding was significantly associated with the domains of incomplete outcome data, free of other bias domains as well as reported antibiotic use and conclusions on weight gain. Conclusion In RCTs on infants fed infant formula containing probiotics, prebiotics or synbiotics, the source of funding did not influence the majority of outcomes in favour of the sponsors’ products. More non-industry funded research is needed to further assess the impact of funding on methodological quality, reported clinical outcomes and authors’ conclusions. PMID:24219082

Maternal long chain polyunsaturated fatty acid supplementation in infancy increases length- and weight-for-age but not BMI to 6 years when controlling for effects of maternal smoking

PubMed Central

Currie, L.M.; Tolley, E.A.; Thodosoff, J.M.; Kerling, E.H.; Sullivan, D.K.; Colombo, J.; Carlson, S.E.

2015-01-01

Summary Long chain polyunsaturated fatty acids (LCPUFA) are added to infant formula but their effect on long-term growth of children is under studied. We evaluated the effects of feeding LCPUFA-supplemented formula (n=54) compared to control formula (n=15) throughout infancy on growth from birth-6 years. Growth was described using separate models developed with the MIXED procedure of SAS® that included maternal smoking history and gender. Compared to children fed control formula, children who consumed LCPUFA supplemented formula had higher length-/stature-/and weight-for-age percentiles but not body mass index (BMI) percentile from birth to 6 years. Maternal smoking predicted lower stature (2-6 years), higher weight-for-length (birth-18 months) and BMI percentile (2-6 years) independent of LCPUFA effects. Gender interacted with the effect of LCPUFA on stature, and the relationship between smoking and BMI, with a larger effect for boys. Energy intake did not explain growth differences. A relatively small control sample is a limitation. PMID:25936840

An Analysis of Shelf Space Allocation at the Wright-Patterson Air Force Base Commissary.

DTIC Science & Technology

1987-09-01

Company performed a major shelf space allocation study involving 59 of their stores. The study involved planning and executing a shelf by shelf reset...Betty Crocker Chocolate .a9 2 Betty CrocKer Yellow .93 3 Betty Crocker Devils Food .92 4 Betty Crocker Choc . Choc . Chip .94 5 Betty Crocker German...Headquarters Air Force Commissary Services. ACOS Executive Summary. 28 January 19d6. 12. deadquarters Air Force Commissary Services. Store _Layout

Nucleotide supplementation and the growth of term small for gestational age infants.

PubMed Central

Cosgrove, M.; Davies, D. P.; Jenkins, H. R.

1996-01-01

A double blind randomised controlled trial in small for gestational age (SGA) infants, whose intestinal mucosa was shown to be functionally impaired as a result of intrauterine undernutrition, was carried out to investigate the hypothesis that nucleotide supplementation of a milk formula could improve catchup growth. Anthropometric data were collected on 74 infants, 39 randomly allocated to the nucleotide supplemented group (group N) and 35 to a standard formula group (group S). From study entry to 2 months of age, infants in group N had significantly higher mean rates of weight gain (106.3 compared with 94.7 g/kg baseline weight/week) and length gain (21.8 v 19.7 mm/m baseline length/week). Over the whole six months for which the trial formula was provided group N had significantly higher mean rates of gain of weight (80.1 compared with 71.8 g/kg baseline weight/week), length (16.2 compared with 15.0 mm/m baseline length/week), and head circumference (11.8 compared with 10.8 mm/m baseline head circumference/week). Catchup growth in SGA infants is therefore improved by nucleotide supplementation of infant formula. PMID:8777659

A person based formula for allocating commissioning funds to general practices in England: development of a statistical model

PubMed Central

Smith, Peter; Gravelle, Hugh; Martin, Steve; Bardsley, Martin; Rice, Nigel; Georghiou, Theo; Dusheiko, Mark; Billings, John; Lorenzo, Michael De; Sanderson, Colin

2011-01-01

Objectives To develop a formula for allocating resources for commissioning hospital care to all general practices in England based on the health needs of the people registered in each practice Design Multivariate prospective statistical models were developed in which routinely collected electronic information from 2005-6 and 2006-7 on individuals and the areas in which they lived was used to predict their costs of hospital care in the next year, 2007-8. Data on individuals included all diagnoses recorded at any inpatient admission. Models were developed on a random sample of 5 million people and validated on a second random sample of 5 million people and a third sample of 5 million people drawn from a random sample of practices. Setting All general practices in England as of 1 April 2007. All NHS inpatient admissions and outpatient attendances for individuals registered with a general practice on that date. Subjects All individuals registered with a general practice in England at 1 April 2007. Main outcome measures Power of the statistical models to predict the costs of the individual patient or each practice’s registered population for 2007-8 tested with a range of metrics (R2 reported here). Comparisons of predicted costs in 2007-8 with actual costs incurred in the same year were calculated by individual and by practice. Results Models including person level information (age, sex, and ICD-10 codes diagnostic recorded) and a range of area level information (such as socioeconomic deprivation and supply of health facilities) were most predictive of costs. After accounting for person level variables, area level variables added little explanatory power. The best models for resource allocation could predict upwards of 77% of the variation in costs at practice level, and about 12% at the person level. With these models, the predicted costs of about a third of practices would exceed or undershoot the actual costs by 10% or more. Smaller practices were more likely to be in these groups. Conclusions A model was developed that performed well by international standards, and could be used for allocations to practices for commissioning. The best formulas, however, could predict only about 12% of the variation in next year’s costs of most inpatient and outpatient NHS care for each individual. Person-based diagnostic data significantly added to the predictive power of the models. PMID:22110252

Traffic offense sentencing processes and highway safety. Volume 1, Summary report

DOT National Transportation Integrated Search

1977-04-01

The history and development of traffic offense sanctions are reviewed. Criteria for traffic offense sanctions are discussed in terms of evenness, economy, appropriateness, rational allocation, effectiveness and parsimony. The framework for developmen...

Amtrak performance tracking (APT) system : methodology summary

DOT National Transportation Integrated Search

2017-09-15

The Volpe Center collaborated with Amtrak and the Federal Railroad Administration (FRA) to develop a cost accounting system named Amtrak Performance Tracking (APT) used by Amtrak to manage, allocate, and report its costs. APTs initial development ...

Sample path analysis of contribution and reward in cooperative groups.

PubMed

Toyoizumi, Hiroshi

2009-02-07

Explaining cooperative behavior is one of the major challenges in both biology and human society. The individual reward in cooperative group depends on how we share the rewards in the group. Thus, the group size dynamics in a cooperative group and reward-allocation rule seem essential to evaluate the emergence of cooperative groups. We apply a sample path-based analysis called an extension of Little's formula to general cooperative group. We show that the expected reward is insensitive to the specific reward-allocation rule and probabilistic structure of group dynamics, and the simple productivity condition guarantees the expected reward to be larger than the average contribution. As an example, we take social queues to see the insensitivity result in detail.

Estimating regression coefficients from clustered samples: Sampling errors and optimum sample allocation

NASA Technical Reports Server (NTRS)

Kalton, G.

1983-01-01

A number of surveys were conducted to study the relationship between the level of aircraft or traffic noise exposure experienced by people living in a particular area and their annoyance with it. These surveys generally employ a clustered sample design which affects the precision of the survey estimates. Regression analysis of annoyance on noise measures and other variables is often an important component of the survey analysis. Formulae are presented for estimating the standard errors of regression coefficients and ratio of regression coefficients that are applicable with a two- or three-stage clustered sample design. Using a simple cost function, they also determine the optimum allocation of the sample across the stages of the sample design for the estimation of a regression coefficient.

Packet flow monitoring tool and method

DOEpatents

Thiede, David R [Richland, WA

2009-07-14

A system and method for converting packet streams into session summaries. Session summaries are a group of packets each having a common source and destination internet protocol (IP) address, and, if present in the packets, common ports. The system first captures packets from a transport layer of a network of computer systems, then decodes the packets captured to determine the destination IP address and the source IP address. The system then identifies packets having common destination IP addresses and source IP addresses, then writes the decoded packets to an allocated memory structure as session summaries in a queue.

No effect of adding dairy lipids or long chain polyunsaturated fatty acids on formula tolerance and growth in full term infants: a randomized controlled trial.

PubMed

Gianni, Maria Lorella; Roggero, Paola; Baudry, Charlotte; Fressange-Mazda, Catherine; le Ruyet, Pascale; Mosca, Fabio

2018-01-22

When breastfeeding is not possible, infants are fed formulas in which lipids are usually of plant origin. However, the use of dairy fat in combination with plant oils enables a lipid profile in formula closer to breast milk in terms of fatty acid composition, triglyceride structure and cholesterol content. The objectives of this study were to investigate the impact on growth and gastrointestinal tolerance of a formula containing a mix of dairy lipids and plant oils in healthy infants. This study was a monocentric, double-blind, controlled, randomized trial. Healthy term infants aged less than 3 weeks whose mothers did not breastfeed were randomly allocated to formula containing either: a mix of plant oils and dairy fat (D), only plant oils (P) or plant oils supplemented with long-chain polyunsaturated fatty acids (PDHA). Breastfed infants were included in a reference group (BF). Anthropometric parameters and body composition were measured after 2 and 4 months. Gastrointestinal tolerance was evaluated during 2 day-periods after 1 and 3 months thanks to descriptive parameters reported by parents. Nonrandomized BF infants were not included in the statistical analysis. Eighty eight formula-fed and 29 BF infants were enrolled. Gains of weight, recumbent length, cranial circumference and fat mass were similar between the 3 formula-fed groups at 2 and 4 months and close to those of BF. Z-scores for weight, recumbent length and cranial circumference in all groups were within normal ranges for growth standards. No significant differences were noted among the 3 formula groups in gastrointestinal parameters (stool frequency/consistency/color), occurrence of gastrointestinal symptoms (abdominal pain, flatulence, regurgitation) or infant's behavior. A formula containing a mix of dairy lipids and plant oils enables a normal growth in healthy newborns. This formula is well tolerated and does not lead to abnormal gastrointestinal symptoms. Consequently, reintroduction of dairy lipids could represent an interesting strategy to improve lipid quality in infant formulas. ClinicalTrials.gov Identifier NCT01611649 , retrospectively registered on May 25, 2012.

Curation and Allocation of the New Antarctic Nakhlite, MIL03346

NASA Technical Reports Server (NTRS)

McBride, K. M.; Righter, K.; Satterwhite, C. E.; Schwarz, C.; Robinson, P.

2005-01-01

In January 2004, the ANSMET reconnaissance field team (Fig. 1) working in the Miller Range of the Transantarctic Mountains discovered a 715 g achondrite that was instantly recognized as unique. Named MIL03346, initial processing (NASA Johnson Space Center or JSC) and classification (Smithsonian Institution or SI) revealed this achondrite to be a nakhlite (Fig. 2). MIL03346 is the seventh nakhlite recognized in world collections [2], the third nakhlite returned from Antartica, and the first nakhlite in the US Antarctic collection (Table 1). The following is a summary of the steps taken in the processing and allocating of MIL 03346 and some comparisons to some other lunar and martian meteorites processed and allocated at JSC.

78 FR 35022 - Parker-Davis Project-Rate Order No. WAPA-162

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... DEPARTMENT OF ENERGY Western Area Power Administration Parker-Davis Project-Rate Order No. WAPA-162 AGENCY: Western Area Power Administration, DOE. ACTION: Notice of Proposed Extension of Firm Electric and Transmission Service Formula Rates. SUMMARY: The Western Area Power Administration (Western...

Summary of the Department of Transportation Rail-Highway Crossing Accident Prediction Formulas and Resource Model

DOT National Transportation Integrated Search

1982-09-01

The Highway Safety Acts of 1973 and 1976, and the Surface Transportation Assistance Act of 1978, provide funding authorizations to individual states to improve safety at public rail-highway crossings. The installation of active motorist warning devic...

77 FR 2961 - North Pacific Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... Pacific Fishery Management Council; Public Meeting AGENCY: National Marine Fisheries Service (NMFS... Fishery Management Council Golden King Crab Price Formula Workgroup. SUMMARY: The North Pacific Fishery... 1201 3rd Avenue, Suite 4800, Seattle, WA 98121-3099. Council address: North Pacific Fishery Management...

The Measure of Poverty: A Report to Congress as Mandated by The Education Amendments of 1974.

ERIC Educational Resources Information Center

Department of Health, Education, and Welfare, Washington, DC. Office of the Under Secretary.

A study of ways of improving the accuracy and currency of the present measure of poverty used in the formula that allocates funds authorized by Title I of the Elementary and Secondary Education Act (ESEA) is summated by this report. It Deals with measuring the current status of the poor rather than with the causes or solutions to poverty. The…

Improving the Academic Achievement of the Disadvantaged; Migrant Education Program. Final Rule. Federal Register, Department of Education, 34 CFR Part 200

ERIC Educational Resources Information Center

National Archives and Records Administration, 2008

2008-01-01

The Secretary amends the regulations governing the Migrant Education Program (MEP) administered under Part C of Title I of the Elementary and Secondary Education Act of 1965, as amended (ESEA). These final regulations adjust the base amounts of the MEP Basic State Formula grant allocations for fiscal year (FY) 2006 and subsequent years (as well…

Direct estimation and correction of bias from temporally variable non-stationary noise in a channelized Hotelling model observer.

PubMed

Fetterly, Kenneth A; Favazza, Christopher P

2016-08-07

Channelized Hotelling model observer (CHO) methods were developed to assess performance of an x-ray angiography system. The analytical methods included correction for known bias error due to finite sampling. Detectability indices ([Formula: see text]) corresponding to disk-shaped objects with diameters in the range 0.5-4 mm were calculated. Application of the CHO for variable detector target dose (DTD) in the range 6-240 nGy frame(-1) resulted in [Formula: see text] estimates which were as much as 2.9×  greater than expected of a quantum limited system. Over-estimation of [Formula: see text] was presumed to be a result of bias error due to temporally variable non-stationary noise. Statistical theory which allows for independent contributions of 'signal' from a test object (o) and temporally variable non-stationary noise (ns) was developed. The theory demonstrates that the biased [Formula: see text] is the sum of the detectability indices associated with the test object [Formula: see text] and non-stationary noise ([Formula: see text]). Given the nature of the imaging system and the experimental methods, [Formula: see text] cannot be directly determined independent of [Formula: see text]. However, methods to estimate [Formula: see text] independent of [Formula: see text] were developed. In accordance with the theory, [Formula: see text] was subtracted from experimental estimates of [Formula: see text], providing an unbiased estimate of [Formula: see text]. Estimates of [Formula: see text] exhibited trends consistent with expectations of an angiography system that is quantum limited for high DTD and compromised by detector electronic readout noise for low DTD conditions. Results suggest that these methods provide [Formula: see text] estimates which are accurate and precise for [Formula: see text]. Further, results demonstrated that the source of bias was detector electronic readout noise. In summary, this work presents theory and methods to test for the presence of bias in Hotelling model observers due to temporally variable non-stationary noise and correct this bias when the temporally variable non-stationary noise is independent and additive with respect to the test object signal.

Why does primary angioplasty not work in registries? Quantifying the susceptibility of real-world comparative effectiveness data to allocation bias.

PubMed

Sen, Sayan; Davies, Justin E; Malik, Iqbal S; Foale, Rodney A; Mikhail, Ghada W; Hadjiloizou, Nearchos; Hughes, Alun; Mayet, Jamil; Francis, Darrel P

2012-11-01

Meta-analysis of registries (comparative effectiveness research) shows that primary angioplasty and fibrinolysis have equivalent real-world survival. Yet, randomized, controlled trials consistently find primary angioplasty superior. Can unequal allocation of higher-risk patients in registries have masked primary angioplasty benefit? First, we constructed a model to demonstrate the potential effect of allocation bias. We then analyzed published registries (55022 patients) for allocation of higher-risk patients (Killip class ≥1) to determine whether the choice of reperfusion therapy was affected by the risk level of the patient. Meta-regression was used to examine the relationship between differences in allocation of high-risk patient to primary angioplasty or fibrinolysis and mortality. Initial modeling suggested that registry outcomes are sensitive to allocation bias of high-risk patients. Across the registries, the therapy receiving excess high-risk patients had worse mortality. Unequal distribution of high-risk status accounted for most of the between-registry variance (adjusted R(2)(meta)=83.1%). Accounting for differential allocation of higher-risk patients, primary angioplasty gave 22% lower mortality (odds ratio, 0.78; 95% confidence interval, 0.64-0.97; P=0.029). We derive a formula, called the number needed to abolish, highlighting situations in which comparative effectiveness studies are particularly vulnerable to this bias. In ST-segment elevation myocardial infarction, clinicians' preference for management of a few high-risk patients can shift mortality substantially. Comparative effectiveness research in any disease is vulnerable to this, especially diseases with an immediately identifiable high-risk subgroup that clinicians prefer to allocate to 1 therapy. For this reason, preliminary indications from registry-based comparative effectiveness research should be definitively tested by randomized, controlled trials.

Optimal allocation of trend following strategies

NASA Astrophysics Data System (ADS)

Grebenkov, Denis S.; Serror, Jeremy

2015-09-01

We consider a portfolio allocation problem for trend following (TF) strategies on multiple correlated assets. Under simplifying assumptions of a Gaussian market and linear TF strategies, we derive analytical formulas for the mean and variance of the portfolio return. We construct then the optimal portfolio that maximizes risk-adjusted return by accounting for inter-asset correlations. The dynamic allocation problem for n assets is shown to be equivalent to the classical static allocation problem for n2 virtual assets that include lead-lag corrections in positions of TF strategies. The respective roles of asset auto-correlations and inter-asset correlations are investigated in depth for the two-asset case and a sector model. In contrast to the principle of diversification suggesting to treat uncorrelated assets, we show that inter-asset correlations allow one to estimate apparent trends more reliably and to adjust the TF positions more efficiently. If properly accounted for, inter-asset correlations are not deteriorative but beneficial for portfolio management that can open new profit opportunities for trend followers. These concepts are illustrated using daily returns of three highly correlated futures markets: the E-mini S&P 500, Euro Stoxx 50 index, and the US 10-year T-note futures.

HAPRAP: a haplotype-based iterative method for statistical fine mapping using GWAS summary statistics.

PubMed

Zheng, Jie; Rodriguez, Santiago; Laurin, Charles; Baird, Denis; Trela-Larsen, Lea; Erzurumluoglu, Mesut A; Zheng, Yi; White, Jon; Giambartolomei, Claudia; Zabaneh, Delilah; Morris, Richard; Kumari, Meena; Casas, Juan P; Hingorani, Aroon D; Evans, David M; Gaunt, Tom R; Day, Ian N M

2017-01-01

Fine mapping is a widely used approach for identifying the causal variant(s) at disease-associated loci. Standard methods (e.g. multiple regression) require individual level genotypes. Recent fine mapping methods using summary-level data require the pairwise correlation coefficients ([Formula: see text]) of the variants. However, haplotypes rather than pairwise [Formula: see text], are the true biological representation of linkage disequilibrium (LD) among multiple loci. In this article, we present an empirical iterative method, HAPlotype Regional Association analysis Program (HAPRAP), that enables fine mapping using summary statistics and haplotype information from an individual-level reference panel. Simulations with individual-level genotypes show that the results of HAPRAP and multiple regression are highly consistent. In simulation with summary-level data, we demonstrate that HAPRAP is less sensitive to poor LD estimates. In a parametric simulation using Genetic Investigation of ANthropometric Traits height data, HAPRAP performs well with a small training sample size (N < 2000) while other methods become suboptimal. Moreover, HAPRAP's performance is not affected substantially by single nucleotide polymorphisms (SNPs) with low minor allele frequencies. We applied the method to existing quantitative trait and binary outcome meta-analyses (human height, QTc interval and gallbladder disease); all previous reported association signals were replicated and two additional variants were independently associated with human height. Due to the growing availability of summary level data, the value of HAPRAP is likely to increase markedly for future analyses (e.g. functional prediction and identification of instruments for Mendelian randomization). The HAPRAP package and documentation are available at http://apps.biocompute.org.uk/haprap/ CONTACT: : jie.zheng@bristol.ac.uk or tom.gaunt@bristol.ac.ukSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

76 FR 28767 - Desert Southwest Customer Service Region-Rate Order No. WAPA-152

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... Temporarily Extending Network Integration Transmission Service (NITS). SUMMARY: This action is to temporarily... Administration, Rate Extension for Desert Southwest Region Network Integration Transmission Service and WALC... Integration Transmission Service and Ancillary Services Formula Rates Section 302 of the Department of Energy...

Comparison of growth and nutritional status in infants receiving goat milk-based formula and cow milk-based formula: a randomized, double-blind study.

PubMed

Xu, Meihong; Wang, Yibin; Dai, Zhiyong; Zhang, Yanchun; Li, Yong; Wang, Junbo

2015-01-01

To compare the growth and nutritional status of infants fed goat milk-based formula (GMF) and cow milk-based formula (CMF). The study was conducted in Beijing, China. It was a double-blind randomized controlled trial. A total of 79 infants aged 0-3 months old were recruited and randomized in GMF or CMF group. The infants were fed the allocated formula to 6 months. The weight, length, and head circumference were measured at the enrolment, 3 and 6 months. The start time and types of solid food were recorded. Blood elements, urinal, and fecal parameters were also tested. The average weight of infants in the GMF group (mean±SD) was 4.67±0.99 kg and in the CMF group 4.73±1.10 kg at enrolment, and 8.75±0.98 kg (GMF) and 8.92±0.88 kg (CMF) at 6 months. There were no differences in the adjusted intention-to-treat analyses of weight, length, head circumference, and BMI z-scores between the two formula-fed groups over the 6-month study. Similarly, there were no remarkable differences in the timing and types of solid food, blood elements, urinal, and feces parameters, between the GMF and CMF group. No group differences have been shown in bowel motion consistency, duration of crying, ease of settling, or frequency of adverse events. GMF-provided growth and nutritional outcomes did not differ from those provided by CMF.

Benefit cost models to support pavement management decisions : executive summary report.

DOT National Transportation Integrated Search

2012-01-01

A critical role of pavement management is to : provide decision makers with estimates of the : required budget level to achieve specific steadystate : network conditions, and to recommend the : best allocation of available budget among : competing ne...

Statistical and operational summaries

NASA Technical Reports Server (NTRS)

Disalvo, J.

1972-01-01

Statistical progress indicator forms are presented on the financial management of the research allocations. Promotional activities, conference participants, and services are tabulated. The staffing and activity levels are also discussed, as well as the fee schedule revision and the standard interest profile offerings.

78 FR 60883 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0545... Request; Infant Formula Requirements AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing that a proposed collection of information has...

75 FR 48350 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0190... Request; Infant Formula Requirements AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing that a proposed collection of information has...

Hierarchical tone mapping for high dynamic range image visualization

NASA Astrophysics Data System (ADS)

Qiu, Guoping; Duan, Jiang

2005-07-01

In this paper, we present a computationally efficient, practically easy to use tone mapping techniques for the visualization of high dynamic range (HDR) images in low dynamic range (LDR) reproduction devices. The new method, termed hierarchical nonlinear linear (HNL) tone-mapping operator maps the pixels in two hierarchical steps. The first step allocates appropriate numbers of LDR display levels to different HDR intensity intervals according to the pixel densities of the intervals. The second step linearly maps the HDR intensity intervals to theirs allocated LDR display levels. In the developed HNL scheme, the assignment of LDR display levels to HDR intensity intervals is controlled by a very simple and flexible formula with a single adjustable parameter. We also show that our new operators can be used for the effective enhancement of ordinary images.

Summary of DOT Rail-Highway Crossing Resource Allocation Procedure - Revised

DOT National Transportation Integrated Search

1987-06-01

The Highway Safety Acts of 1973 and 1976, and the Surface Transportation Assistance Acts of 1978 and 1982 provide funding authorizations to individual states to improve safety at public rail-highway crossings. The installation of active motorist warn...

Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species.

PubMed

Bonneau, Stephane; Maynard, Laurence; Tomczuk, Krzysztof; Kok, Dawid; Eun, Hyone-Myong

2009-09-01

In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n = 6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.

High-performance liquid chromatography coupled with tandem mass spectrometry technology in the analysis of Chinese Medicine Formulas: A bibliometric analysis (1997-2015).

PubMed

He, Xi-Ran; Li, Chun-Guang; Zhu, Xiao-Shu; Li, Yuan-Qing; Jarouche, Mariam; Bensoussan, Alan; Li, Ping-Ping

2017-01-01

There is a recognized challenge in analyzing traditional Chinese medicine formulas because of their complex chemical compositions. The application of modern analytical techniques such as high-performance liquid chromatography coupled with a tandem mass spectrometry has improved the characterization of various compounds from traditional Chinese medicine formulas significantly. This study aims to conduct a bibliometric analysis to recognize the overall trend of high-performance liquid chromatography coupled with tandem mass spectrometry approaches in the analysis of traditional Chinese medicine formulas, its significance and possible underlying interactions between individual herbs in these formulas. Electronic databases were searched systematically, and the identified studies were collected and analyzed using Microsoft Access 2010, Graph Pad 5.0 software and Ucinet software package. 338 publications between 1997 and 2015 were identified, and analyzed in terms of annual growth and accumulated publications, top journals, forms of traditional Chinese medicine preparations and highly studied formulas and single herbs, as well as social network analysis of single herbs. There is a significant increase trend in using high-performance liquid chromatography coupled with tandem mass spectrometry related techniques in analysis of commonly used forms of traditional Chinese medicine formulas in the last 3 years. Stringent quality control is of great significance for the modernization and globalization of traditional Chinese medicine, and this bibliometric analysis provided the first and comprehensive summary within this field. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Decentralization in Zambia: resource allocation and district performance.

PubMed

Bossert, Thomas; Chitah, Mukosha Bona; Bowser, Diana

2003-12-01

Zambia implemented an ambitious process of health sector decentralization in the mid 1990s. This article presents an assessment of the degree of decentralization, called 'decision space', that was allowed to districts in Zambia, and an analysis of data on districts available at the national level to assess allocation choices made by local authorities and some indicators of the performance of the health systems under decentralization. The Zambian officials in health districts had a moderate range of choice over expenditures, user fees, contracting, targeting and governance. Their choices were quite limited over salaries and allowances and they did not have control over additional major sources of revenue, like local taxes. The study found that the formula for allocation of government funding which was based on population size and hospital beds resulted in relatively equal per capita expenditures among districts. Decentralization allowed the districts to make decisions on internal allocation of resources and on user fee levels and expenditures. General guidelines for the allocation of resources established a maximum and minimum percentage to be allocated to district offices, hospitals, health centres and communities. Districts tended to exceed the maximum for district offices, but the large urban districts and those without public district hospitals were not even reaching the minimum for hospital allocations. Wealthier and urban districts were more successful in raising revenue through user fees, although the proportion of total expenditures that came from user fees was low. An analysis of available indicators of performance, such as the utilization of health services, immunization coverage and family planning activities, found little variation during the period 1995-98 except for a decline in immunization coverage, which may have also been affected by changes in donor funding. These findings suggest that decentralization may not have had either a positive or negative impact on services.

Equity in the allocation of public sector financial resources in low- and middle-income countries: a systematic literature review.

PubMed

Anselmi, Laura; Lagarde, Mylene; Hanson, Kara

2015-05-01

This review aims to identify, assess and analyse the evidence on equity in the distribution of public health sector expenditure in low- and middle-income countries. Four bibliographic databases and five websites were searched to identify quantitative studies examining equity in the distribution of public health funding in individual countries or groups of countries. Two different types of studies were identified: benefit incidence analysis (BIA) and resource allocation comparison (RAC) studies. Quality appraisal and data synthesis were tailored to each study type to reflect differences in the methods used and in the information provided. We identified 39 studies focusing on African, Asian and Latin American countries. Of these, 31 were BIA studies that described the distribution, typically across socio-economic status, of individual monetary benefit derived from service utilization. The remaining eight were RAC studies that compared the actual expenditure across geographic areas to an ideal need-based distribution. Overall, the quality of the evidence from both types of study was relatively weak. Looking across studies, the evidence confirms that resource allocation formulae can enhance equity in resource allocation across geographic areas and that the poor benefits proportionally more from primary health care than from hospital expenditure. The lack of information on the distribution of benefit from utilization in RAC studies and on the countries' approaches to resource allocation in BIA studies prevents further policy analysis. Additional research that relates the type of resource allocation mechanism to service provision and to the benefit distribution is required for a better understanding of equity-enhancing resource allocation policies. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine © The Author 2014; all rights reserved.

Sample size requirements for the design of reliability studies: precision consideration.

PubMed

Shieh, Gwowen

2014-09-01

In multilevel modeling, the intraclass correlation coefficient based on the one-way random-effects model is routinely employed to measure the reliability or degree of resemblance among group members. To facilitate the advocated practice of reporting confidence intervals in future reliability studies, this article presents exact sample size procedures for precise interval estimation of the intraclass correlation coefficient under various allocation and cost structures. Although the suggested approaches do not admit explicit sample size formulas and require special algorithms for carrying out iterative computations, they are more accurate than the closed-form formulas constructed from large-sample approximations with respect to the expected width and assurance probability criteria. This investigation notes the deficiency of existing methods and expands the sample size methodology for the design of reliability studies that have not previously been discussed in the literature.

The human role in space. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1984-01-01

The role and degree of direct involvement of humans required in future space missions were investigated. Criteria for allocating functional activities between humans and machines were established. The technology requirements, economics, and benefits of the human presence in space were investigated.

NC roadway lighting needs assessment, maintenance prioritization tool and performance measures.

DOT National Transportation Integrated Search

2013-05-01

The objectives of this project are to 1) develop an assessment report and summary of accumulated modernization / replacement needs, 2) assess current lighting needs and develop a method to allocate funds at NCDOT Division level, 3) research and docum...

Review of medical discharge summaries and medical documentation in a metropolitan hospital: impact on diagnostic-related groups and Weighted Inlier Equivalent Separation.

PubMed

Chin, N; Perera, P; Roberts, A; Nagappan, R

2013-07-01

Accurate and comprehensive clinical documentation is crucial for effective ongoing patient care, follow up and to optimise case mix-based funding. Each Diagnostic Related Group (DRG) is assigned a 'weight', leading to Weighted Inlier Equivalent Separation (WIES), a system many public and private hospitals in Australia subscribe to. To identify the top DRG in a general medical inpatient service, the completeness of medical discharge documentation, commonly missed comorbidities and system-related issues and subsequent impact on DRG and WIES allocation. One hundred and fifty completed discharge summaries were randomly selected from the top 10 medical DRG in our health service. From a detailed review of the clinical documentation, principal diagnoses, associated comorbidities and complications, where appropriate, the DRG and WIES were modified. Seventy-two (48%) of the 150 reviewed admissions resulted in a revision of DRG and WIES equivalent to an increase of AUD 142,000. Respiratory-based DRG generated the largest revision of DRG and WIES, while 'Cellulitis' DRG had the largest relative change. Twenty-seven per cent of summaries reviewed necessitated a change in coding with no subsequent change in DRG allocation or WIES. Acute renal failure, anaemia and electrolyte disturbances were the most commonly underrepresented entities in clinical discharge documentation. Seven patients had their WIES downgraded. Comprehensive documentation of principal diagnosis/diagnoses, comorbidities and their complications is imperative to optimal DRG and WIES allocation. Regular meetings between clinical and coding staff improve the quality and timeliness of medical documentation, ensure adequate communication with general practitioners and lead to appropriate funding. © 2013 The Authors; Internal Medicine Journal © 2013 Royal Australasian College of Physicians.

76 FR 59682 - Desert Southwest Customer Service Region-Western Area Lower Colorado Balancing Authority-Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... percentage of metered generation, since there is no load. 2. Intermittent resources are exempt from the outer...--Western Area Lower Colorado Balancing Authority--Rate Order No. WAPA-151 AGENCY: Western Area Power... Services Formula Rates. SUMMARY: The Deputy Secretary of Energy has confirmed and approved Rate Order No...

New Jersey Graduated Work Incentive Experiment. Summary Report.

ERIC Educational Resources Information Center

Mathematica, Princeton, NJ.

The study is described as a carefully controlled field test of the effects on recipient families of eight different negative income tax or benefit formulas. The most striking finding was that observed changes in labor supply in response to the experimental payments were generally quite small. Chapter One, The Experiment: Background and Choices,…

Reviewing RAWP. Variations in admission rates: implications for equitable allocation of resources.

PubMed Central

Bevan, G; Ingram, R

1987-01-01

The review of the Resource Allocation Working Party (RAWP) formula by the National Health Service Management Board has considered the method used to account for cross boundary flows between health authorities. There is no consensus on how this should be done subregionally, as it raises the unresolved problem of the best method of estimating the size of catchment populations. Different methods produce different population sizes when the admission rates of individuals living in different districts vary. The National Health Service/Department of Health and Social Security acute services working group on performance indicators recently considered the assumptions made by different methods in terms of admission thresholds set by hospital clinicians. More complicated methods of assessing catchment areas seem to offer little advantage over the simplest method, but none of the methods answer the underlying questions of what truly determines admission rates and whether higher admission rates are better than lower ones. Empirical research into variations in admission rates and their relation to outcomes is important for determining the fair allocation of resources in future. PMID:3120865

Into the 80s: Our Schools and Their Purposes.

ERIC Educational Resources Information Center

South Australia Education Dept., Adelaide.

Complementing existing regulations, this policy statement for South Australian schools presents educational goals and priorities for the decade and general implications for classroom, curriculum, and resource allocation. Background discussion covers factors influencing recent developments in South Australian education, a summary of the role of…

A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure.

PubMed

Wang, Jia-Bo; Cui, He-Rong; Wang, Rui-Lin; Zhang, Cong-En; Niu, Ming; Bai, Zhao-Fang; Xu, Gen-Hua; Li, Peng-Yan; Jiang, Wen-Yan; Han, Jing-Jing; Ma, Xiao; Cai, Guang-Ming; Li, Rui-Sheng; Zhang, Li-Ping; Xiao, Xiao-He

2018-04-04

Multiple components of traditional Chinese medicine (TCM) formulae determine their treatment targets for multiple diseases as opposed to a particular disease. However, discovering the unexplored therapeutic potential of a TCM formula remains challenging and costly. Inspired by the drug repositioning methodology, we propose an integrated strategy to feasibly identify new therapeutic uses for a formula composed of six herbs, Liuweiwuling. First, we developed a comprehensive systems approach to enrich drug compound-liver disease networks to analyse the major predicted diseases of Liuweiwuling and discover its potential effect on liver failure. The underlying mechanisms were subsequently predicted to mainly attribute to a blockade of hepatocyte apoptosis via a synergistic combination of multiple effects. Next, a classical pharmacology experiment was designed to validate the effects of Liuweiwuling on different models of fulminant liver failure induced by D-galactosamine/lipopolysaccharide (GalN/LPS) or thioacetamide (TAA). The results indicated that pretreatment with Liuweiwuling restored liver function and reduced lethality induced by GalN/LPS or TAA in a dose-dependent manner, which was partially attributable to the abrogation of hepatocyte apoptosis by multiple synergistic effects. In summary, the integrated strategy discussed in this paper may provide a new approach for the more efficient discovery of new therapeutic uses for TCM formulae.

Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial.

PubMed

Boyle, R J; Tang, M L-K; Chiang, W C; Chua, M C; Ismail, I; Nauta, A; Hourihane, J O B; Smith, P; Gold, M; Ziegler, J; Peake, J; Quinn, P; Rao, R; Brown, N; Rijnierse, A; Garssen, J; Warner, J O

2016-05-01

Prevention guidelines for infants at high risk of allergic disease recommend hydrolysed formula if formula is introduced before 6 months, but evidence is mixed. Adding specific oligosaccharides may improve outcomes. To evaluate whether partially hydrolysed whey formula containing oligosaccharides (0.8 g/100 ml) (pHF-OS) can prevent eczema in high-risk infants [ISRCTN65195597]. We conducted a parallel-group, multicentre, randomized double-blind controlled trial of pHF-OS vs standard cow's milk formula. Infants with a family history of allergic disease were randomized (stratified by centre/maternal allergy) to active (n = 432) or control (n = 431) formula until 6 months of age if formula was introduced before 18 weeks. Primary outcome was cumulative incidence of eczema by 12 months in infants randomized at 0-4 weeks (375 pHF-OS, 383 control). Secondary outcomes were cumulative incidence of eczema by 12 or 18 months in all infants randomized, immune markers at 6 months and adverse events. Eczema occurred by 12 months in 84/293 (28.7%) infants allocated to pHF-OS at 0-4 weeks of age, vs 93/324 (28.7%) control (OR 0.98 95% CI 0.68, 1.40; P = 0.90), and 107/347 (30.8%) pHF-OS vs 112/370 (30.3%) control in all infants randomized (OR 0.99 95% CI 0.71, 1.37; P = 0.94). pHF-OS did not change most immune markers including total/specific IgE; however, pHF-OS reduced cow's milk-specific IgG1 (P < 0.0001) and increased regulatory T-cell and plasmacytoid dendritic cell percentages. There was no group difference in adverse events. pHF-OS does not prevent eczema in the first year in high-risk infants. The immunological changes found require confirmation in a separate cohort. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A Review of AA Psych Corps Involvement in the Allocation of Soldiers to corps and Employment. Executive Summary

DTIC Science & Technology

1990-11-01

Compiled I Lecture Additional Iation/ _____ Testing L J week 2 week 3- 4 week 5 wee 6 week 8 -9 week 10 wee: Allocation Guide: Shows suitability -:r - n cl...the Document box only (Document) la. A R Number lb. Establishment Number 2. Document Date AR-006-388 PSRU RR 4 /90 NOVEMBER 1990 UNCLASSIFIED 3. Title 4 ...of 7 Number of EMI4IIJYM [itl Pages References Title 17 15 8 . Author(s) 9. Downgrading or Delimiting Instructions LTCOL R.C. FURRY I Oa. Corporate

Impact of a nutritional formula enriched in fish oil and micronutrients on pressure ulcers in critical care patients.

PubMed

Theilla, Miriam; Schwartz, Betty; Cohen, Jonathan; Shapiro, Haim; Anbar, Ronit; Singer, Pierre

2012-07-01

Pressure ulcers are an important source of morbidity and suffering for patients and a formidable burden on caregivers. To assess the impact of a feeding formula enriched with fish oil on healing of preexisting pressure ulcers and serum levels of C-reactive protein in critical care patients. Adult patients with pressure ulcers grade II or higher were randomly allocated to receive either a formula enriched with fish oil or an isocaloric control formula. Wound healing was assessed by using the Pressure Ulcer Scale for Healing tool on days 7, 14, and 28. Blood levels of C-reactive protein were measured on days 0, 7, and 14. Baseline demographics did not differ between the study (n = 20) and the control (n = 20) groups. The mean score on the ulcer healing tool increased significantly (P = .02) from day 0 to day 28 in the control group (from 9.25 [SD, 2.12] to 10.75 [SD, 3.41]) compared with the study group (from 9.10 [SD, 2.84] to 9.40 [SD, 3.72]). Mean levels of C-reactive protein decreased significantly (P= .02) from day 0 to day 14 in the study group (from 191 [SD, 104.4] mg/L to 111.7 [SD, 97.8] mg/L) compared with the control group (from 145 [SD, 90] mg/L to 139 [SD, 62] mg/L). Administration of a feeding formula enriched with fish oil was associated with decreased progression of pressure ulcers and a decrease in blood concentrations of C-reactive protein.

76 FR 54999 - Notice of 2011 National Organic Certification Cost-Share Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

...] Notice of 2011 National Organic Certification Cost-Share Program AGENCY: Agricultural Marketing Service... for the National Organic Certification Cost- Share Program. SUMMARY: This Notice invites all States of...) for the allocation of National Organic Certification Cost-Share Funds. Beginning in Fiscal Year 2008...

76 FR 29291 - FTA Supplemental Fiscal Year 2011 Apportionments, Allocations, and Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

.... SUMMARY: The Department of Defense and Full-Year Continuing Appropriations Act, 2011 (Pub. L. 112-10), was... Defense and Full-Year Continuing Appropriations Act, 2011 (Pub. L. 112-10), hereinafter ``Appropriations... DEPARTMENT OF TRANSPORTATION Federal Transit Administration FTA Supplemental Fiscal Year 2011...

75 FR 11841 - Repowering Assistance Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... application window. SUMMARY: RBS is announcing a new application window to submit applications for the...-time application window for remaining FY 2009 funds. Paperwork Reduction Act In accordance with the... allocate all of the FY 2009 authorized funds. Therefore, the Agency is opening a new application window to...

How federalism shapes public health financing, policy, and program options.

PubMed

Ogden, Lydia L

2012-01-01

In the United States, fiscal and functional federalism strongly shape public health policy and programs. Federalism has implications for public health practice: it molds financing and disbursement options, including funding formulas, which affect allocations and program goals, and shapes how funding decisions are operationalized in a political context. This article explores how American federalism, both fiscal and functional, structures public health funding, policy, and program options, investigating the effects of intergovernmental transfers on public health finance and programs.

Statistical Requirements For Pass-Fail Testing Of Contraband Detection Systems

NASA Astrophysics Data System (ADS)

Gilliam, David M.

2011-06-01

Contraband detection systems for homeland security applications are typically tested for probability of detection (PD) and probability of false alarm (PFA) using pass-fail testing protocols. Test protocols usually require specified values for PD and PFA to be demonstrated at a specified level of statistical confidence CL. Based on a recent more theoretical treatment of this subject [1], this summary reviews the definition of CL and provides formulas and spreadsheet functions for constructing tables of general test requirements and for determining the minimum number of tests required. The formulas and tables in this article may be generally applied to many other applications of pass-fail testing, in addition to testing of contraband detection systems.

76 FR 16438 - Reallocation of American Recovery and Reinvestment Act Capital Funds-Capital Fund Grant Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... Recovery and Reinvestment Act Capital Funds--Capital Fund Grant Program Under the American Recovery and...: Notice. SUMMARY: The American Recovery and Reinvestment Act of 2009 (the Recovery Act) included a $4...). The Recovery Act required that $3 billion of these funds be distributed as formula funds and the...

A New Way to Teach (or Compute) Pearson's "r" without Reliance on Cross-Products

ERIC Educational Resources Information Center

Huck, Schuyler W.; Ren, Bixiang; Yang, Hongwei

2007-01-01

Many students have difficulty seeing the conceptual link between bivariate data displayed in a scatterplot and the statistical summary of the relationship, "r." This article shows how to teach (and compute) "r" such that each datum's direct and indirect influences are made apparent and used in a new formula for calculating Pearson's "r."

Nutrient-enriched formula versus standard formula for preterm infants following hospital discharge.

PubMed

Young, Lauren; Embleton, Nicholas D; McGuire, William

2016-12-13

Preterm infants are often growth-restricted at hospital discharge. Feeding nutrient-enriched formula rather than standard formula to infants after hospital discharge might facilitate 'catch-up' growth and might improve development. To compare the effects of nutrient-enriched formula versus standard formula on growth and development of preterm infants after hospital discharge. We used the standard search strategy of the Cochrane Neonatal Review Group. This included searches of the Cochrane Central Register of Controlled Trials (2016, Issue 8) in the Cochrane Library, MEDLINE, Embase and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; to 8 September 2016), as well as conference proceedings and previous reviews. Randomised and quasi-randomised controlled trials that compared the effects of feeding nutrient-enriched formula (postdischarge formula or preterm formula) versus standard term formula to preterm infants after hospital discharge . Two review authors assessed trial eligibility and risk of bias and extracted data independently. We analysed treatment effects as described in the individual trials and reported risk ratios and risk differences for dichotomous data, and mean differences (MDs) for continuous data, with respective 95% confidence intervals (CIs). We used a fixed-effect model in meta-analyses and explored potential causes of heterogeneity by performing sensitivity analyses. We assessed quality of evidence at the outcome level using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. We included 16 eligible trials with a total of 1251 infant participants. Trials were of variable methodological quality, with lack of allocation concealment and incomplete follow-up identified as major potential sources of bias. Trials (N = 11) that compared feeding infants with 'postdischarge formula' (energy density about 74 kcal/100 mL) versus standard term formula (about 67 kcal/100 mL) did not find consistent evidence of effects on growth parameters up to 12 to 18 months post term. GRADE assessments indicated that evidence was of moderate quality, and that inconsistency within pooled estimates was the main quality issue.Trials (N = 5) that compared feeding with 'preterm formula' (about 80 kcal/100 mL) versus term formula found evidence of higher rates of growth throughout infancy (weighted mean differences at 12 to 18 months post term: about 500 g in weight, 5 to 10 mm in length, 5 mm in head circumference). GRADE assessments indicated that evidence was of moderate quality, and that imprecision of estimates was the main quality issue.Few trials assessed neurodevelopmental outcomes, and these trials did not detect differences in developmental indices at 18 months post term. Data on growth or development through later childhood have not been provided. Recommendations to prescribe 'postdischarge formula' for preterm infants after hospital discharge are not supported by available evidence. Limited evidence suggests that feeding 'preterm formula' (which is generally available only for in-hospital use) to preterm infants after hospital discharge may increase growth rates up to 18 months post term.

Discrete physiological effects of beetroot juice and potassium nitrate supplementation following 4-wk sprint interval training.

PubMed

Thompson, Christopher; Vanhatalo, Anni; Kadach, Stefan; Wylie, Lee J; Fulford, Jonathan; Ferguson, Scott K; Blackwell, Jamie R; Bailey, Stephen J; Jones, Andrew M

2018-06-01

The physiological and exercise performance adaptations to sprint interval training (SIT) may be modified by dietary nitrate ([Formula: see text]) supplementation. However, it is possible that different types of [Formula: see text] supplementation evoke divergent physiological and performance adaptations to SIT. The purpose of this study was to compare the effects of 4-wk SIT with and without concurrent dietary [Formula: see text] supplementation administered as either [Formula: see text]-rich beetroot juice (BR) or potassium [Formula: see text] (KNO 3 ). Thirty recreationally active subjects completed a battery of exercise tests before and after a 4-wk intervention in which they were allocated to one of three groups: 1) SIT undertaken without dietary [Formula: see text] supplementation (SIT); 2) SIT accompanied by concurrent BR supplementation (SIT + BR); or 3) SIT accompanied by concurrent KNO 3 supplementation (SIT + KNO 3 ). During severe-intensity exercise, V̇o 2peak and time to task failure were improved to a greater extent with SIT + BR than SIT and SIT + KNO 3 ( P < 0.05). There was also a greater reduction in the accumulation of muscle lactate at 3 min of severe-intensity exercise in SIT + BR compared with SIT + KNO 3 ( P < 0.05). Plasma [Formula: see text] concentration fell to a greater extent during severe-intensity exercise in SIT + BR compared with SIT and SIT + KNO 3 ( P < 0.05). There were no differences between groups in the reduction in the muscle phosphocreatine recovery time constant from pre- to postintervention ( P > 0.05). These findings indicate that 4-wk SIT with concurrent BR supplementation results in greater exercise capacity adaptations compared with SIT alone and SIT with concurrent KNO 3 supplementation. This may be the result of greater NO-mediated signaling in SIT + BR compared with SIT + KNO 3 . NEW & NOTEWORTHY We compared the influence of different forms of dietary nitrate supplementation on the physiological and performance adaptations to sprint interval training (SIT). Compared with SIT alone, supplementation with nitrate-rich beetroot juice, but not potassium [Formula: see text], enhanced some physiological adaptations to training.

Cosmology with the Large Synoptic Survey Telescope: an overview.

PubMed

Zhan, Hu; Anthony Tyson, J

2018-06-01

The Large Synoptic Survey Telescope (LSST) is a high étendue imaging facility that is being constructed atop Cerro Pachón in northern Chile. It is scheduled to begin science operations in 2022. With an [Formula: see text] ([Formula: see text] effective) aperture, a novel three-mirror design achieving a seeing-limited [Formula: see text] field of view, and a 3.2 gigapixel camera, the LSST has the deep-wide-fast imaging capability necessary to carry out an [Formula: see text] survey in six passbands (ugrizy) to a coadded depth of [Formula: see text] over 10 years using [Formula: see text] of its observational time. The remaining [Formula: see text] of the time will be devoted to considerably deeper and faster time-domain observations and smaller surveys. In total, each patch of the sky in the main survey will receive 800 visits allocated across the six passbands with [Formula: see text] exposure visits. The huge volume of high-quality LSST data will provide a wide range of science opportunities and, in particular, open a new era of precision cosmology with unprecedented statistical power and tight control of systematic errors. In this review, we give a brief account of the LSST cosmology program with an emphasis on dark energy investigations. The LSST will address dark energy physics and cosmology in general by exploiting diverse precision probes including large-scale structure, weak lensing, type Ia supernovae, galaxy clusters, and strong lensing. Combined with the cosmic microwave background data, these probes form interlocking tests on the cosmological model and the nature of dark energy in the presence of various systematics. The LSST data products will be made available to the US and Chilean scientific communities and to international partners with no proprietary period. Close collaborations with contemporaneous imaging and spectroscopy surveys observing at a variety of wavelengths, resolutions, depths, and timescales will be a vital part of the LSST science program, which will not only enhance specific studies but, more importantly, also allow a more complete understanding of the Universe through different windows.

Final Report on 1989 Legislation Affecting Community Colleges.

ERIC Educational Resources Information Center

California Community Colleges, Sacramento. Office of the Chancellor.

A summary is provided of 1989 legislation of importance to California community colleges. The first section of the report provides an overview of the 1989 legislative year, including both federal and state issues. State highlights concern extensive negotiations over the allocation of funds to community colleges under the newly enacted Proposition…

77 FR 35671 - Conformed Power Marketing Criteria or Regulations for the Boulder Canyon Project

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

... DEPARTMENT OF ENERGY Western Area Power Administration Conformed Power Marketing Criteria or... of power marketing criteria in accordance with the Hoover Power Allocation Act of 2011. SUMMARY: The Western Area Power Administration (Western), a Federal power marketing agency of the Department of Energy...

75 FR 76921 - Tobacco Transition Payment Program; Tobacco Transition Assessments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... rule; technical amendment. SUMMARY: The Commodity Credit Corporation (CCC) is modifying the regulations... domestic volume of each class. This means that CCC will continue to determine tobacco class allocations... technical amendment does not change how the TTPP is implemented by CCC, but rather clarifies the wording of...

Robust Covariate-Adjusted Log-Rank Statistics and Corresponding Sample Size Formula for Recurrent Events Data

PubMed Central

Song, Rui; Kosorok, Michael R.; Cai, Jianwen

2009-01-01

Summary Recurrent events data are frequently encountered in clinical trials. This article develops robust covariate-adjusted log-rank statistics applied to recurrent events data with arbitrary numbers of events under independent censoring and the corresponding sample size formula. The proposed log-rank tests are robust with respect to different data-generating processes and are adjusted for predictive covariates. It reduces to the Kong and Slud (1997, Biometrika 84, 847–862) setting in the case of a single event. The sample size formula is derived based on the asymptotic normality of the covariate-adjusted log-rank statistics under certain local alternatives and a working model for baseline covariates in the recurrent event data context. When the effect size is small and the baseline covariates do not contain significant information about event times, it reduces to the same form as that of Schoenfeld (1983, Biometrics 39, 499–503) for cases of a single event or independent event times within a subject. We carry out simulations to study the control of type I error and the comparison of powers between several methods in finite samples. The proposed sample size formula is illustrated using data from an rhDNase study. PMID:18162107

Provisional Coding Practices: Are They Really a Waste of Time?

PubMed

Krypuy, Matthew; McCormack, Lena

2006-11-01

In order to facilitate effective clinical coding and hence the precise financial reimbursement of acute services, in 2005 Western District Health Service (WDHS) (located in regional Victoria, Australia) undertook a provisional coding trial for inpatient medical episodes to determine the magnitude and accuracy of clinical documentation. Utilising clinical coding software installed on a laptop computer, provisional coding was undertaken for all current overnight inpatient episodes under each physician one day prior to attending their daily ward round. The provisionally coded episodes were re-coded upon the completion of the discharge summary and the final Diagnostic Related Group (DRG) allocation and weight were compared to the provisional DRG assignment. A total of 54 out of 220 inpatient medical episodes were provisionally coded. This represented approximately a 25% cross section of the population selected for observation. Approximately 67.6% of the provisionally allocated DRGs were accurate in contrast to 32.4% which were subject to change once the discharge summary was completed. The DRG changes were primarily due to: disease progression of a patient during their care episode which could not be identified by clinical coding staff due to discharge prior to the following scheduled ward round; the discharge destination of particular patients; and the accuracy of clinical documentation on the discharge summary. The information gathered from the provisional coding trial supported the hypothesis that clinical documentation standards were sufficient and adequate to support precise clinical coding and DRG assignment at WDHS. The trial further highlighted the importance of a complete and accurate discharge summary available during the coding process of acute inpatient episodes.

Synthesizing Risk from Summary Evidence Across Multiple Risk Factors.

PubMed

Shrier, Ian; Colditz, Graham A; Steele, Russell J

2018-07-01

Although meta-analyses provide summary effect estimates that help advise patient care, patients often want to compare their overall health to the general population. The Harvard Cancer Risk Index was published in 2004 and uses risk ratio estimates and prevalence estimates from original studies across many risk factors to provide an answer to this question. However, the published version of the formula only uses dichotomous risk factors and its derivation was not provided. The objective of this brief report was to provide the derivation of a more general form of the equation that allows the incorporation of risk factors with three or more levels.

Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/[Formula: see text]-Catenin Signaling.

PubMed

Liu, Mingche; Bamodu, Oluwaseun Adebayo; Kuo, Kuang-Tai; Lee, Wei-Hwa; Lin, Yen-Kuang; Wu, Alexander T H; M, Hsiao; Tzeng, Yew-Min; Yeh, Chi-Tai; Tsai, Jo-Ting

2018-01-01

The hierarchical tumor propagation or cancer stem cells (CSCs) model of carcinogenesis postulates that like physiologic adult stem cell (ASC), the CSCs positioned at the apex of any tumor population form the crux of tumor evolution with a constitutive regenerative capacity and differentiation potential. The propagation and recurrence of the characteristically heterogeneous and therapy-resistant hepatocellular carcinoma (HCC), adds to accumulating evidence to support this CSCs model. Based on the multi-etiologic basis of HCC formation which among others, focuses on the disruption of the canonical Wnt signaling pathway, this study evaluated the role of cembrane-type phytochemical, Ovatodiolide, in the modulation of the Wnt/[Formula: see text]-catenin pathway, and its subsequent effect on liver CSCs' activities. Our fluorescence-activated cell sorting (FACS) and quantitative RT-PCR analyses of side population (SP) indicated that CD133+ cells were [Formula: see text]-catenin-overexpressing, more aggressive, and resistant to the conventional anticancer agents, Cisplatin and Doxorubicin, when compared to [Formula: see text]-catenin-downregulated group. We demonstrated that marked upregulation of [Formula: see text]-catenin and its downstream targets effectively enhanced hepatosphere formation, with an associated induction of CD133, OCT4 and Sox2 expression and also caused an significant enhancement of HCC proliferation. However, treatment with Ovatodiolide induced downregulation of [Formula: see text]-catenin and its downstream effector genes, abolished hepatosphere formation and reversed the [Formula: see text]-catenin-associated enhancement of HCC growth. In summary, we demonstrated for the first time that Ovatodiolide suppressed the canonical Wnt signaling pathway, and inhibited the generation of liver CSCs; Thus, projecting Ovatodiolide as a putatively effective therapeutic agent for anti-HCC target therapy.

The influence of a formula supplemented with dairy lipids and plant oils on the erythrocyte membrane omega-3 fatty acid profile in healthy full-term infants: a double-blind randomized controlled trial

PubMed Central

2012-01-01

Background Human milk is the optimal nutrition for infants. When breastfeeding is not possible, supplementation of infant formula with long chain polyunsaturated fatty acids appears to promote neurodevelopmental outcome and visual function. Plant oils, that are the only source of fat in most of infant formulas, do not contain specific fatty acids that are present in human and cow milk and do not encounter milk fat triglyceride structure. Experimental data suggest that a mix of dairy lipids and plant oils can potentiate endogenous synthesis of n-3 long chain polyunsaturated fatty acids. This trial aims to determine the effect of an infant formula supplemented with a mixture of dairy lipids and plant oils on the erythrocyte membrane omega-3 fatty acid profile in full-term infants (primary outcome). Erythrocyte membrane long chain polyunsaturated fatty acids and fatty acids content, the plasma lipid profile and the insulin-growth factor 1 level, the gastrointestinal tolerance, the changes throughout the study in blood fatty acids content, in growth and body composition are evaluated as secondary outcomes. Methods/Design In a double-blind controlled randomized trial, 75 healthy full-term infants are randomly allocated to receive for four months a formula supplemented with a mixture of dairy lipids and plant oils or a formula containing only plant oils or a formula containing plant oils supplemented with arachidonic acid and docosahexaenoic acid. Twenty-five breast-fed infants constitute the reference group. Erythrocyte membrane omega-3 fatty acid profile, long chain polyunsaturated fatty acids and the other fatty acids content, the plasma lipid profile and the insulin-growth factor 1 level are measured after four months of intervention. Gastrointestinal tolerance, the changes in blood fatty acids content, in growth and body composition, assessed by means of an air displacement plethysmography system, are also evaluated throughout the study. Discussion The achievement of an appropriate long chain polyunsaturated fatty acids status represents an important goal in neonatal nutrition. Gaining further insight in the effects of the supplementation of a formula with dairy lipids and plant oils in healthy full-term infants could help to produce a formula whose fat content, composition and structure is more similar to human milk. Trial registration ClinicalTrials.gov Identifier NCT01611649 PMID:23072617

The influence of a formula supplemented with dairy lipids and plant oils on the erythrocyte membrane omega-3 fatty acid profile in healthy full-term infants: a double-blind randomized controlled trial.

PubMed

Giannì, Maria Lorella; Roggero, Paola; Baudry, Charlotte; Ligneul, Amandine; Morniroli, Daniela; Garbarino, Francesca; le Ruyet, Pascale; Mosca, Fabio

2012-10-17

Human milk is the optimal nutrition for infants. When breastfeeding is not possible, supplementation of infant formula with long chain polyunsaturated fatty acids appears to promote neurodevelopmental outcome and visual function. Plant oils, that are the only source of fat in most of infant formulas, do not contain specific fatty acids that are present in human and cow milk and do not encounter milk fat triglyceride structure. Experimental data suggest that a mix of dairy lipids and plant oils can potentiate endogenous synthesis of n-3 long chain polyunsaturated fatty acids. This trial aims to determine the effect of an infant formula supplemented with a mixture of dairy lipids and plant oils on the erythrocyte membrane omega-3 fatty acid profile in full-term infants (primary outcome). Erythrocyte membrane long chain polyunsaturated fatty acids and fatty acids content, the plasma lipid profile and the insulin-growth factor 1 level, the gastrointestinal tolerance, the changes throughout the study in blood fatty acids content, in growth and body composition are evaluated as secondary outcomes. In a double-blind controlled randomized trial, 75 healthy full-term infants are randomly allocated to receive for four months a formula supplemented with a mixture of dairy lipids and plant oils or a formula containing only plant oils or a formula containing plant oils supplemented with arachidonic acid and docosahexaenoic acid. Twenty-five breast-fed infants constitute the reference group. Erythrocyte membrane omega-3 fatty acid profile, long chain polyunsaturated fatty acids and the other fatty acids content, the plasma lipid profile and the insulin-growth factor 1 level are measured after four months of intervention. Gastrointestinal tolerance, the changes in blood fatty acids content, in growth and body composition, assessed by means of an air displacement plethysmography system, are also evaluated throughout the study. The achievement of an appropriate long chain polyunsaturated fatty acids status represents an important goal in neonatal nutrition. Gaining further insight in the effects of the supplementation of a formula with dairy lipids and plant oils in healthy full-term infants could help to produce a formula whose fat content, composition and structure is more similar to human milk. ClinicalTrials.gov Identifier NCT01611649.

Physics Education Research in the United States: A Summary of Its Rationale and Main Findings.

ERIC Educational Resources Information Center

Gonzales-Espada, Wilson J.

2003-01-01

Recognizes how difficult it is for secondary and post-secondary students to make connections between physics and everyday phenomena, rationalize the use of a particular formula for a given problem, and go beyond algebraic substitutions to really make sense of physics in a meaningful way. Provides a rationale for physicists to become involved in…

The State Dollar and the Schools. A Discussion of State Aid Programs in Massachusetts and Promising Reforms.

ERIC Educational Resources Information Center

Ryan, Charlotte

This report discusses the history and nature of State aid to education in Massachusetts. The report is both a summary and an update of information contained in four earlier studies that analyzed the economics of education in Massachusetts and the State's new equalizing education aid formula. The report recommends that the State adopt an…

Statistical Requirements For Pass-Fail Testing Of Contraband Detection Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilliam, David M.

2011-06-01

Contraband detection systems for homeland security applications are typically tested for probability of detection (PD) and probability of false alarm (PFA) using pass-fail testing protocols. Test protocols usually require specified values for PD and PFA to be demonstrated at a specified level of statistical confidence CL. Based on a recent more theoretical treatment of this subject [1], this summary reviews the definition of CL and provides formulas and spreadsheet functions for constructing tables of general test requirements and for determining the minimum number of tests required. The formulas and tables in this article may be generally applied to many othermore » applications of pass-fail testing, in addition to testing of contraband detection systems.« less

Prevention of age-related macular degeneration.

PubMed

Wong, Ian Yat Hin; Koo, Simon Chi Yan; Chan, Clement Wai Nang

2011-02-01

Age-related macular degeneration (AMD) is one of the leading causes of blindness in the developed world. Although effective treatment modalities such as anti-VEGF treatment have been developed for neovascular AMD, there is still no effective treatment for geographical atrophy, and therefore the most cost-effective management of AMD is to start with prevention. This review looks at current evidence on preventive measures targeted at AMD. Modalities reviewed include (1) nutritional supplements such as the Age-Related Eye Disease Study (AREDS) formula, lutein and zeaxanthin, omega-3 fatty acid, and berry extracts, (2) lifestyle modifications, including smoking and body-mass-index, and (3) filtering sunlight, i.e. sunglasses and blue-blocking intraocular lenses. In summary, the only proven effective preventive measures are stopping smoking and the AREDS formula.

77 FR 52262 - Fisheries of the Northeastern United States; Summer Flounder Fishery; Commercial Quota Harvested...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

.... 111220786-1781-01] RIN 0648-XC176 Fisheries of the Northeastern United States; Summer Flounder Fishery...; closure. SUMMARY: NMFS announces that the 2012 summer flounder commercial quota allocated to the... summer flounder fishery may not land summer flounder in Massachusetts for the remainder of calendar year...

75 FR 52890 - Fisheries of the Northeastern United States; Summer Flounder Fishery; Commercial Quota Harvested...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

.... 0908191244-91427ndash;02] RIN 0648-XY35 Fisheries of the Northeastern United States; Summer Flounder Fishery...; closure. SUMMARY: NMFS announces that the 2010 summer flounder commercial quota allocated to the... summer flounder fishery may not land summer flounder in Massachusetts for the remainder of calendar year...

78 FR 51096 - Fisheries of the Northeastern United States; Summer Flounder Fishery; Commercial Quota Harvested...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

.... 111220786-1781-01] RIN 0648-XC811 Fisheries of the Northeastern United States; Summer Flounder Fishery...; closure. SUMMARY: NMFS announces that the 2013 summer flounder commercial quota allocated to the... summer flounder fishery may not land summer flounder in Massachusetts for the remainder of calendar year...

76 FR 73632 - Sunshine Act Meeting; Open Commission Meeting; Wednesday, November 30, 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... Rules to Provide Additional Spectrum for the Medical Device Radiocommunication Service in the 413-457 MHz band SUMMARY: The Commission will consider a Report and Order that allocates spectrum in the 413-457 MHz band and adopts service and technical rules for Medical Micropower Networks, which rely on new...

Causes of Indoor Air Quality Problems in Schools: Summary of Scientific Research. Revised Edition.

ERIC Educational Resources Information Center

Bayer, Charlene W.; Crow, Sidney A.; Fischer, John

Understanding the primary causes of indoor air quality (IAQ) problems and how controllable factors--proper heating, ventilation and air-conditioning (HVAC) system design, allocation of adequate outdoor air, proper filtration, effective humidity control, and routine maintenance--can avert problems may help all building owners, operators, and…

76 FR 65662 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Coastal Migratory Pelagic...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... Migratory Pelagic Resources in the Gulf of Mexico and Atlantic Region; Amendment 18 AGENCY: National Marine... rule; request for comments. SUMMARY: NMFS proposes regulations to implement Amendment 18 to the Fishery..., Amendment 18 would set allocations for Atlantic cobia and establish control rules for king mackerel, Spanish...

Defense Acquisition: Observations Two Years After the Packard Commission

DTIC Science & Technology

1988-11-01

AiSTER THE PACKARD COMMISSION, VOLUME 1: MAIN REPORT 12 . .L = (ýesce Kanter, Bart.ar Bicksler, H. Marshall Hoyler, Robert Hilton, Walter Locke, George...Organization in the Military Services ..............-.... M 12 D. Summary ............................................................................. 1-17...IV- 12 B. The Resource Allocation Process ............................ IV-14 1. T1z Planning Phase

Title VI Summary 2000-2001.

ERIC Educational Resources Information Center

Huskey, Barton

Title VI provides federal funds to states under the Elementary and Secondary Education Act of 1965. This document describes Title VI programs and the use of funds in the Austin Independent School District (AISD), Texas for 2000-2001. The AISD allocation of $481,559 was based on the May 2000 projected school enrollment, including projected…

Combined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia.

PubMed

Yang, Nae-Cherng; Chou, Chien-Wen; Chen, Chung-Yin; Hwang, Kai-Lin; Yang, Yi-Chueh

2009-01-01

The purpose of this randomized, double-blind, placebo-controlled, parallel comparison study was to evaluate the lipid-lowering effect of orally administrated nattokinase and nattokinase combined with red yeast rice (RYR) extract on blood lipids in patients with hyperlipidemia. A total of 47 patients with hyperlipidemia were assigned to one of three groups: 1. nattokinase-mono formula (50 mg/capsule), 2. combined formula of nattokinase with RYR (300 mg of extract/capsule) and 3. placebo. Subjects received a twice daily dose of two capsules for six months. The mono formula showed no effects on blood lipids until month six, while the combined formula ameliorated all of measured lipids starting from month one. In the combined group significant decreases were found with regard to: triglycerides (TG) by 15%, total cholesterol (TC) by 25%, low-density lipoprotein cholesterol (LDL-C) by 41%, TC/high-density lipoprotein cholesterol (HDL-C) ratio by 29.5%, and increases in HDL-C by 7.5%. These changes were sustained until the end of study. After controlling for baseline levels, only the combined group, but not mono group, showed a significant difference (p<0.0001) in TC, LDL-C and TC/HDL-C ratio when compared with the placebo group. In summary, this study provides long-term efficacy of nattokinase supplementation and shows that the combined formula has relatively more potent effects than the mono formula on lowering of blood lipids, suggesting that combined nattokinase with RYR will be a better neutraceutical for patients with hyperlipidemia than nattokinase alone.

Reliability of computer-assisted periacetabular osteotomy using a minimally invasive approach.

PubMed

De Raedt, Sepp; Mechlenburg, Inger; Stilling, Maiken; Rømer, Lone; Murphy, Ryan J; Armand, Mehran; Lepistö, Jyri; de Bruijne, Marleen; Søballe, Kjeld

2018-06-06

Periacetabular osteotomy (PAO) is the treatment of choice for younger patients with developmental hip dysplasia. The procedure aims to normalize the joint configuration, reduce the peak-pressure, and delay the development of osteoarthritis. The procedure is technically demanding and no previous study has validated the use of computer navigation with a minimally invasive transsartorial approach. Computer-assisted PAO was performed on ten patients. Patients underwent pre- and postoperative computed tomography (CT) scanning with a standardized protocol. Preoperative preparation consisted of outlining the lunate surface and segmenting the pelvis and femur from CT data. The Biomechanical Guidance System was used intra-operatively to automatically calculate diagnostic angles and peak-pressure measurements. Manual diagnostic angle measurements were performed based on pre- and postoperative CT. Differences in angle measurements were investigated with summary statistics, intraclass correlation coefficient, and Bland-Altman plots. The percentage postoperative change in peak-pressure was calculated. Intra-operative reported angle measurements show a good agreement with manual angle measurements with intraclass correlation coefficient between 0.94 and 0.98. Computer navigation reported angle measurements were significantly higher for the posterior sector angle ([Formula: see text], [Formula: see text]) and the acetabular anteversion angle ([Formula: see text], [Formula: see text]). No significant difference was found for the center-edge ([Formula: see text]), acetabular index ([Formula: see text]), and anterior sector angle ([Formula: see text]). Peak-pressure after PAO decreased by a mean of 13% and was significantly different ([Formula: see text]). We found that computer navigation can reliably be used with a minimally invasive transsartorial approach PAO. Angle measurements generally agree with manual measurements and peak-pressure was shown to decrease postoperatively. With further development, the system will become a valuable tool in the operating room for both experienced and less experienced surgeons performing PAO. Further studies with a larger cohort and follow-up will allow us to investigate the association with peak-pressure and postoperative outcome and pave the way to clinical introduction.

Heuristic Algorithms for Solving Two Dimensional Loading Problems.

DTIC Science & Technology

1981-03-01

L6i MICROCOPY RESOLUTION TEST CHART WTI0WAL BL4WA64OF STANDARDS- 1963-A -~~ le -I I ~- A-LA4C TEC1-NlCAL ’c:LJ? HEURISTIC ALGORITHMS FOR SOLVING...CONSIDER THE FOLLOWjING PROBLEM; ALLOCATE A SET OF ON’ DOXES, EACH HAVING A SPECIFIED LENGTH, WIDTH AND HEIGHT, TO A PALLET OF LENGTH " Le AND WIDTH "W...THE BOXES AND TI-EN-SELECT TI- lE BEST SOLUTION. SINCE THESE HEURISTICS ARE ESSENTIALLY A TRIAL AND ERROR PROCEDURE THEIR FORMULAS BECOME VERY

Nonregulatory Guidance To Assist State Educational Agencies in Administering Federal Financial Assistance to Local Educational Agencies for Projects Designed To Meet the Special Educational Needs of Educationally Deprived Children under Chapter 1 of the Education Consolidation and Improvement Act of 1981, as Amended.

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

Chapter 1 of the Education Consolidation and Improvement Act of 1981 (ECIA) provides financial assistance to state (SEAs) and local educational agencies (LEAs) to meet special educational needs under the same formula that governed the allocation of Title I funds. The guidance in this document only pertains to the Chapter 1 program that provides…

Summary of methods for calculating dynamic lateral stability and response and for estimating aerodynamic stability derivatives

NASA Technical Reports Server (NTRS)

Campbell, John P; Mckinney, Marion O

1952-01-01

A summary of methods for making dynamic lateral stability and response calculations and for estimating the aerodynamic stability derivatives required for use in these calculations is presented. The processes of performing calculations of the time histories of lateral motions, of the period and damping of these motions, and of the lateral stability boundaries are presented as a series of simple straightforward steps. Existing methods for estimating the stability derivatives are summarized and, in some cases, simple new empirical formulas are presented. Detailed estimation methods are presented for low-subsonic-speed conditions but only a brief discussion and a list of references are given for transonic and supersonic speed conditions.

75 FR 23620 - Magnuson-Stevens Act Provisions; Fisheries Off West Coast States; Pacific Coast Groundfish...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... regarding which model formulation reflected the best available science for Pacific whiting in 2010, and put... measures for 2011-12. Based on the SSC advice that both models be put forward as the best available science... specifications and tribal allocation; request for comments. SUMMARY: This final rule establishes the 2010 fishery...

Effects of Text-Belief Consistency and Reading Task on the Strategic Validation of Multiple Texts

ERIC Educational Resources Information Center

Maier, Johanna; Richter, Tobias

2016-01-01

In the comprehension of multiple controversial scientific texts, readers with strong prior beliefs tend to construct a one-sided mental representation that is biased towards belief-consistent information. In the present study, we examined whether an argument in contrast to a summary task instruction can increase the resource allocation to and…

Realigning Resources for District Success: Duval County Public Schools Final Report. Executive Summary

ERIC Educational Resources Information Center

Travers, Jonathan; Ferris, Kristen

2011-01-01

Duval County Public Schools (DCPS) is poised to take action today that will lead to serving all students more effectively. Although the challenges are significant, including deep budget cuts, the district made the strategic choice to look thoroughly at how resources are currently allocated and now has a foundation for making decisions that will…

Early Childhood Intervention Programs: What Are the Costs and Benefits? Congressional Research Briefing Summary.

ERIC Educational Resources Information Center

Brooks-Gunn, Jeanne; Currie, Janet; Besharov, Douglas J.

While recent research in cognitive development suggests that the period from birth to age 3 provides a unique opportunity for interventions to change the life-course of children, there is great disagreement regarding the best means of allocating public funds toward early childhood intervention. Further, there is little research into the long-term…

[Discussion on efficacy evaluation thought and method for innovation medicine of Chinese herbal compound formula based on clinical application characteristics].

PubMed

Sun, Jian-Ning; Sun, Wen-Yan; Dong, Shi-Fen

2017-03-01

The Chinese herbal compound formula preparation was made based on theory of Chinese medicine, which was confirmed by long period clinical application, and with multi-compound and multi-target characteristics. During the exploitation process of innovation medicine of Chinese herbal compound formula, selecting and speeding up the research development of drugs with clinical value shall be paid more attention, and as request of rules involved in new drug research and development, the whole process management should be carried out, including project evaluation, manufacturing process determination, establishment of quality control standards, evaluation for pharmacological and toxic effect, as well as new drug application process. This reviews was aimed to give some proposals for pharmacodynamics research methods involved in exploration of Chinese herbal compound formula preparation, including： ①the endpoint criteria should meet the clinical attribution of new drugs; ②the pre-clinical pharmacodynamics evaluation should be carried on appropriate animal models according to the characteristics of diagnosis and therapy of Chinese medicine and observation indexes; ③during the innovation of drug for infants and children, information on drug action conforming to physiological characteristics of infants and children should be supplied, and the pharmacodynamics and toxicology research shall be conducted in immature rats according to the body weight of children. In a summary, the clinical application characteristics are the important criteria for evaluation of pharmacological effect of innovation medicine of Chinese herbal compound formula. Copyright© by the Chinese Pharmaceutical Association.

Design of price incentives for adjunct policy goals in formula funding for hospitals and health services

PubMed Central

Duckett, Stephen J

2008-01-01

Background Hospital policy involves multiple objectives: efficiency of service delivery, pursuit of high quality care, promoting access. Funding policy based on hospital casemix has traditionally been considered to be only about promoting efficiency. Discussion Formula-based funding policy can be (and has been) used to pursue a range of policy objectives, not only efficiency. These are termed 'adjunct' goals. Strategies to incorporate adjunct goals into funding design must, implicitly or explicitly, address key decision choices outlined in this paper. Summary Policy must be clear and explicit about the behaviour to be rewarded; incentives must be designed so that all facilities with an opportunity to improve have an opportunity to benefit; the reward structure is stable and meaningful; and the funder monitors performance and gaming. PMID:18384694

Prevention of age-related macular degeneration

PubMed Central

Koo, Simon Chi Yan; Chan, Clement Wai Nang

2010-01-01

Age-related macular degeneration (AMD) is one of the leading causes of blindness in the developed world. Although effective treatment modalities such as anti-VEGF treatment have been developed for neovascular AMD, there is still no effective treatment for geographical atrophy, and therefore the most cost-effective management of AMD is to start with prevention. This review looks at current evidence on preventive measures targeted at AMD. Modalities reviewed include (1) nutritional supplements such as the Age-Related Eye Disease Study (AREDS) formula, lutein and zeaxanthin, omega-3 fatty acid, and berry extracts, (2) lifestyle modifications, including smoking and body-mass-index, and (3) filtering sunlight, i.e. sunglasses and blue-blocking intraocular lenses. In summary, the only proven effective preventive measures are stopping smoking and the AREDS formula. PMID:20862519

Cluster randomised crossover trials with binary data and unbalanced cluster sizes: application to studies of near-universal interventions in intensive care.

PubMed

Forbes, Andrew B; Akram, Muhammad; Pilcher, David; Cooper, Jamie; Bellomo, Rinaldo

2015-02-01

Cluster randomised crossover trials have been utilised in recent years in the health and social sciences. Methods for analysis have been proposed; however, for binary outcomes, these have received little assessment of their appropriateness. In addition, methods for determination of sample size are currently limited to balanced cluster sizes both between clusters and between periods within clusters. This article aims to extend this work to unbalanced situations and to evaluate the properties of a variety of methods for analysis of binary data, with a particular focus on the setting of potential trials of near-universal interventions in intensive care to reduce in-hospital mortality. We derive a formula for sample size estimation for unbalanced cluster sizes, and apply it to the intensive care setting to demonstrate the utility of the cluster crossover design. We conduct a numerical simulation of the design in the intensive care setting and for more general configurations, and we assess the performance of three cluster summary estimators and an individual-data estimator based on binomial-identity-link regression. For settings similar to the intensive care scenario involving large cluster sizes and small intra-cluster correlations, the sample size formulae developed and analysis methods investigated are found to be appropriate, with the unweighted cluster summary method performing well relative to the more optimal but more complex inverse-variance weighted method. More generally, we find that the unweighted and cluster-size-weighted summary methods perform well, with the relative efficiency of each largely determined systematically from the study design parameters. Performance of individual-data regression is adequate with small cluster sizes but becomes inefficient for large, unbalanced cluster sizes. When outcome prevalences are 6% or less and the within-cluster-within-period correlation is 0.05 or larger, all methods display sub-nominal confidence interval coverage, with the less prevalent the outcome the worse the coverage. As with all simulation studies, conclusions are limited to the configurations studied. We confined attention to detecting intervention effects on an absolute risk scale using marginal models and did not explore properties of binary random effects models. Cluster crossover designs with binary outcomes can be analysed using simple cluster summary methods, and sample size in unbalanced cluster size settings can be determined using relatively straightforward formulae. However, caution needs to be applied in situations with low prevalence outcomes and moderate to high intra-cluster correlations. © The Author(s) 2014.

Resource allocation and funding challenges for regional local health departments in Nebraska.

PubMed

Chen, Li-Wu; Jacobson, Janelle; Roberts, Sara; Palm, David

2012-01-01

This study examined the mechanism of resource allocation among member counties and the funding challenges of regional health departments (RHDs) in Nebraska. DESIGN AND STUDY SETTING: In 2009, we conducted a qualitative case study of 2 Nebraska RHDs to gain insight into their experiences of making resource allocation decisions and confronting funding challenges. The 2 RHD sites were selected for this case study on the basis of their heterogeneity in terms of population distribution in member counties. Sixteen semistructured in-person interviews were conducted with RHD directors, staff, and board of health members. Interview data were coded and analyzed using NVivo qualitative analysis software (QSR International [Americas] Inc., Cambridge, MA). Our findings suggested that the directors of RHDs play an integral role in making resource allocation decisions on the basis of community needs, not on a formula or on individual county population size. Interviewees also reported that the size of the vulnerable population served by the RHD had a significant impact on the level of resources for RHD's programs. The RHD's decisions about resource allocation were also dependent on the amount and type of resources received from the state. Interviewees identified inadequacy and instability of funding as the 2 main funding challenges for their RHD. These challenges negatively impacted workforce capacity and the long-term sustainability of some programs. Regional health departments may not benefit from better leveraging resources and building a stronger structural capacity unless the issues of funding inadequacy and instability are addressed. Strategies that can be used by RHDs to address these funding challenges include seeking grants to support programs, leveraging existing resources, and building community partnerships to share resources. Future research is needed to identify RHDs' optimal workforce capacity, required funding level, and potential funding mechanisms.

Summary of Tactile User Interfaces Techniques and Systems

NASA Technical Reports Server (NTRS)

Spirkovska, Lilly

2005-01-01

Mental workload can be de.ned as the ratio of demand to allocated resources. Multiple-resource theory stresses the importance of distribution of tasks and information across various human sensory channels to reduce mental workload. One sensory channel that has been of interest since the late 1800s is touch. Unlike the more typical displays that target vision or hearing, tactile displays present information to the user s sense of touch. We present a summary of different methods for tactile display, historic and more recent systems that incorporate tactile display for information presentation, advantages and disadvantages of targeting the tactile channel, and future directions in tactile display research.

Summary of Tactile User Interfaces Techniques and Systems

NASA Technical Reports Server (NTRS)

Spirkovska, Lilly

2004-01-01

Mental workload can be defined as the ratio of demand to allocated resources. Multiple- resource theory stresses the importance of distribution of tasks and information across various sensory channels of the human to reduce mental workload. One sensory channel that has been of interest since the late 1800s is touch. Unlike the more typical displays that target vision or hearing, tactile displays present information to the user s sense of touch. We present a summary of different methods for tactile display; historic and more recent systems that incorporate tactile display for information presentation; advantages and disadvantages of targeting the tactile channel; and future directions in tactile display research.

Financial impact of spinal cord stimulation on the healthcare budget: a comparative analysis of costs in Canada and the United States.

PubMed

Kumar, Krishna; Bishop, Sharon

2009-06-01

Many institutions with spinal cord stimulation (SCS) programs fail to realize that besides the initial implantation cost, budgetary allocation must be made to address annual maintenance costs as well as complications as they arise. Complications remain the major contributing factor to the overall expense of SCS. The authors present a formula that, when applied, provides a realistic representation of the actual costs necessary to implant and maintain SCS systems in Canada and the US. The authors performed a retrospective analysis of 197 cases involving SCS (161 implanted and 36 failed trial stimulations) between 1995 and 2006. The cost of patient workup, initial implantation, annual maintenance, and resources necessary to resolve complications were assessed for each case and a unit cost applied. The total cost allocated for each case was determined by summing across healthcare resource headings. Using the same parameters, the unit cost was calculated in both Canadian (CAD) and US dollars (USD) at 2007 prices. The cost of implanting a SCS system in Canada is $21,595 (CAD), in US Medicare $32,882 (USD), and in US Blue Cross Blue Shield (BCBS) $57,896 (USD). The annual maintenance cost of an uncomplicated case in Canada is $3539 (CAD), in US Medicare $5071 (USD), and in BCBS $7277 (USD). The mean cost of a complication was $5191 in Canada (range $136-18,837 [CAD]). In comparison, in the US the figures were $9649 (range $381-28,495) for Medicare and $21,390 (range $573-54,547) for BCBS (both USD). Using these calculations a formula was derived as follows: the annual maintenance cost (a) was added to the average annual cost per complication per patient implanted (b); the sum was then divided by the implantation cost (c); and the result was multiplied by 100 to obtain a percentage (a + b / c x 100). To make this budgetary cap universally applicable, the results from the application of the formula were averaged, resulting in an 18% premium. For budgeting purposes the institution should first calculate the initial implantation costs that then can be "grossed up" by 18% per annum. This amount of 18% should be in addition to the implantation costs for the individual institution for new patients, as well as for each actively managed patient. This resulting amount will cover the costs associated with annual maintenance and complications for every actively managed patient. As the initial cost of implantation in any country reflects their current economics, the formula provided will be applicable to all implanters and policy makers alike.

Health care funding in New South Wales: from health care needs to hospital outputs.

PubMed

Hindle, Don

2002-01-01

This paper summarises the structure of the State's health care system, and then focuses on the main processes of resource allocation: needs-based funding of 17 Area Health Services, and output-based funding of specific service providers. The general model is widely accepted by informed observers to be fundamentally sound. In particular, the resource distribution formula whereby needs-based allocations are made is a largely valid model that has been progressively refined over fifteen years and is probably as good as any in the world. I conclude that the recent decision to require Area Health Services to use a common framework for out-put-based funding was long overdue, and that many of its features represent best practice. However, I argue that more should be done to refine some of the details and that NSW Health might need to give more consideration to ideas that have been tested and evaluated in other health care systems.

Dynamic Positioning Capability Analysis for Marine Vessels Based on A DPCap Polar Plot Program

NASA Astrophysics Data System (ADS)

Wang, Lei; Yang, Jian-min; Xu, Sheng-wen

2018-03-01

Dynamic positioning capability (DPCap) analysis is essential in the selection of thrusters, in their configuration, and during preliminary investigation of the positioning ability of a newly designed vessel dynamic positioning system. DPCap analysis can help determine the maximum environmental forces, in which the DP system can counteract in given headings. The accuracy of the DPCap analysis is determined by the precise estimation of the environmental forces as well as the effectiveness of the thrust allocation logic. This paper is dedicated to developing an effective and efficient software program for the DPCap analysis for marine vessels. Estimation of the environmental forces can be obtained by model tests, hydrodynamic computation and empirical formulas. A quadratic programming method is adopted to allocate the total thrust on every thruster of the vessel. A detailed description of the thrust allocation logic of the software program is given. The effectiveness of the new program DPCap Polar Plot (DPCPP) was validated by a DPCap analysis for a supply vessel. The present study indicates that the developed program can be used in the DPCap analysis for marine vessels. Moreover, DPCap analysis considering the thruster failure mode might give guidance to the designers of vessels whose thrusters need to be safer.

A SUMMARY REPORT AND EVALUATION OF TITLE I, P.L. 89-10, PROJECTS, SCHOOL YEAR 1965-66.

ERIC Educational Resources Information Center

IGE, PHILIP K.

THIS EVALUATION REPORT OF HAWAII'S ELEMENTARY AND SECONDARY EDUCATION ACT, TITLE I, ACTIVITIES PRESENTS INFORMATION ABOUT THE NUMBER OF PROJECTS, THE NUMBER AND PERCENTAGE OF STUDENTS AND SCHOOLS COVERED BY TITLE I, AND THE ALLOCATIONS OF TITLE I FUNDS IN THE SEVEN SCHOOL DISTRICTS. IT ALSO DISCUSSES PERSONNEL, SERVICES, PROJECTS, EQUIPMENT, AND…

Identification of Priority Forests in the Upper Mississippi River System: A Summary

Treesearch

Jason Rohweder; Theresa Heyer; Samuel Osinde; Darrell Zastrow; Steve Westin; Al Todd

2007-01-01

The goal of the Upper Mississippi Forest Partnership is to improve water quality and migratory bird habitat by restoring and enhancing forests in the six-state watershed. This document summarizes the results of a GIS analysis that identified forests where allocation of resources would make the most difference. Also included in this document are case studies that...

78 FR 42718 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch in the Bering Sea and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

.... 121018563-3148-02] RIN 0648-XC757 Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Ocean Perch...; closure. SUMMARY: NMFS is prohibiting directed fishing for Pacific ocean perch in the Western Aleutian... allowable catch (TAC) of Pacific ocean perch in this area allocated to vessels participating in the BSAI...

The optimal design of stepped wedge trials with equal allocation to sequences and a comparison to other trial designs.

PubMed

Thompson, Jennifer A; Fielding, Katherine; Hargreaves, James; Copas, Andrew

2017-12-01

Background/Aims We sought to optimise the design of stepped wedge trials with an equal allocation of clusters to sequences and explored sample size comparisons with alternative trial designs. Methods We developed a new expression for the design effect for a stepped wedge trial, assuming that observations are equally correlated within clusters and an equal number of observations in each period between sequences switching to the intervention. We minimised the design effect with respect to (1) the fraction of observations before the first and after the final sequence switches (the periods with all clusters in the control or intervention condition, respectively) and (2) the number of sequences. We compared the design effect of this optimised stepped wedge trial to the design effects of a parallel cluster-randomised trial, a cluster-randomised trial with baseline observations, and a hybrid trial design (a mixture of cluster-randomised trial and stepped wedge trial) with the same total cluster size for all designs. Results We found that a stepped wedge trial with an equal allocation to sequences is optimised by obtaining all observations after the first sequence switches and before the final sequence switches to the intervention; this means that the first sequence remains in the control condition and the last sequence remains in the intervention condition for the duration of the trial. With this design, the optimal number of sequences is [Formula: see text], where [Formula: see text] is the cluster-mean correlation, [Formula: see text] is the intracluster correlation coefficient, and m is the total cluster size. The optimal number of sequences is small when the intracluster correlation coefficient and cluster size are small and large when the intracluster correlation coefficient or cluster size is large. A cluster-randomised trial remains more efficient than the optimised stepped wedge trial when the intracluster correlation coefficient or cluster size is small. A cluster-randomised trial with baseline observations always requires a larger sample size than the optimised stepped wedge trial. The hybrid design can always give an equally or more efficient design, but will be at most 5% more efficient. We provide a strategy for selecting a design if the optimal number of sequences is unfeasible. For a non-optimal number of sequences, the sample size may be reduced by allowing a proportion of observations before the first or after the final sequence has switched. Conclusion The standard stepped wedge trial is inefficient. To reduce sample sizes when a hybrid design is unfeasible, stepped wedge trial designs should have no observations before the first sequence switches or after the final sequence switches.

Social Determinants of Health in Managed Care Payment Formulas.

PubMed

Ash, Arlene S; Mick, Eric O; Ellis, Randall P; Kiefe, Catarina I; Allison, Jeroan J; Clark, Melissa A

2017-10-01

Managed care payment formulas commonly allocate more money for medically complex populations, but ignore most social determinants of health (SDH). To add SDH variables to a diagnosis-based payment formula that allocates funds to managed care plans and accountable care organizations. Using data from MassHealth, the Massachusetts Medicaid and Children's Health Insurance Program, we estimated regression models predicting Medicaid spending using a diagnosis-based and SDH-expanded model, and compared the accuracy of their cost predictions overall and for vulnerable populations. MassHealth members enrolled for at least 6 months in 2013 in fee-for-service (FFS) programs (n = 357 660) or managed care organizations (MCOs) (n = 524 607). We built cost prediction models from a fee-for-service program. Predictors in the diagnosis-based model are age, sex, and diagnoses from claims. The SDH model adds predictors describing housing instability, behavioral health issues, disability, and neighborhood-level stressors. Overall model explanatory power and overpayments and underpayments for subgroups of interest for all Medicaid-reimbursable expenditures excepting long-term support services (mean annual cost = $5590 per member). We studied 357 660 people who were FFS participants and 524 607 enrolled in MCOs with a combined 806 889 person-years of experience. The FFS program experience included more men (49.6% vs 43.6%), older patients (mean age of 26.1 years vs 21.6 years), and sicker patients (mean morbidity score of 1.16 vs 0.89) than MCOs. Overall, the SDH model performed well, but only slightly better than the diagnosis-based model, explaining most of the spending variation in the managed care population (validated R2 = 62.4) and reducing underpayments for several vulnerable populations. For example, raw costs for the quintile of people living in the most stressed neighborhoods were 9.6% ($537 per member per year) higher than average. Since greater medical morbidity accounts for much of this difference, the diagnosis-based model underpredicts costs for the most stressed quintile by about 2.1% ($130 per member per year). The expanded model eliminates the neighborhood-based underpayment, as well as underpayments of 72% for clients of the Department of Mental Health (observed costs of about $30 000 per year) and of 7% for those with serious mental illness (observed costs of about $16 000 per year). Since October 2016, MassHealth has used an expanded model to allocate payments from a prespecified total budget to managed care organizations according to their enrollees' social and medical risk. Extra payments for socially vulnerable individuals could fund activities, such as housing assistance, that could improve health equity.

Thermodynamic derivation of open circuit voltage in vanadium redox flow batteries

NASA Astrophysics Data System (ADS)

Pavelka, Michal; Wandschneider, Frank; Mazur, Petr

2015-10-01

Open circuit voltage of vanadium redox flow batteries is carefully calculated using equilibrium thermodynamics. This analysis reveals some terms in the Nernst relation which are usually omitted in literature. Due to the careful thermodynamic treatment, all uncertainties about the form of Nernst relation are removed except for uncertainties in activity coefficients of particular species. Moreover, it is shown (based again on equilibrium thermodynamics) that batteries with anion-exchange membranes follow different Nernst relation than batteries with cation-exchange membranes. The difference is calculated, and it is verified experimentally that the formula for anion-exchange membranes describes experiments with anion-exchange membranes better than the corresponding formula for cation-exchange membranes. In summary, careful thermodynamic calculation of open circuit voltage of vanadium redox flow batteries is presented, and the difference between voltage for anion-exchange and cation-exchange membranes is revealed.

Content, Social, and Metacognitive Statements: An Empirical Study Comparing Human-Human and Human-Computer Tutorial Dialogue

DTIC Science & Technology

2010-01-01

for each participant using the formula gain = ( posttest − pretest )/(1− pretest ). 6.2 Content-Learning Correlations The summary of language statistics...differences also affect which factors are correlated with learning gain and user satisfaction. We argue that ITS designers should pay particular...factors are correlated with learning gain and user satisfaction. We argue that ITS designers should pay particular attention to strategies for dealing

A Derivation of the Dick Effect from Control-Loop Models for Periodically Interrogated Passive Frequency Standards

NASA Technical Reports Server (NTRS)

Greenhall, Charles A.

1996-01-01

The phase of a frequency standard that uses periodic interrogation and control of a local oscillator (LO) is degraded by a long-term random-walk component induced by downconversion of LO noise into the loop passband. The Dick formula for the noise level of this degradation can be derived from explicit solotions of two LO control-loop models. A summary of the derivations is given here.

A Multi-scale Cognitive Approach to Intrusion Detection and Response

DTIC Science & Technology

2015-12-28

the behavior of the traffic on the network, either by using mathematical formulas or by replaying packet streams. As a result, simulators depend...large scale. Summary of the most important results We obtained a powerful machine, which has 768 cores and 1.25 TB memory . RBG has been...time. Each client is configured with 1GB memory , 10 GB disk space, and one 100M Ethernet interface. The server nodes include web servers

A Scott bench with ergonomic thorax stabilisation pad improves body posture during preacher arm curl exercise.

PubMed

Biscarini, Andrea; Benvenuti, Paolo; Busti, Daniele; Zanuso, Silvano

2016-05-01

We assessed whether the use of an ergonomic thorax stabilisation pad, during the preacher arm curl exercise, could significantly reduce the excessive shoulder protraction and thoracic kyphosis induced by the standard flat pad built into the existing preacher arm curl equipment. A 3D motion capture system and inclinometers were used to measure shoulder protraction and thoracic kyphosis in 15 subjects performing preacher arm curl with a plate-loaded machine provided with the standard flat pad. The same measures were repeated after replacing the flat pad with a new ergonomic pad, specifically designed to accommodate the thorax profile and improve body posture. Pad replacement significantly (p < 0.001) reduced shoulder protraction (from [Formula: see text] to [Formula: see text]) and thoracic kyphosis (from [Formula: see text] to [Formula: see text]), enabling postural and functional improvements within the entire spine, shoulder girdle and rib cage. The ergonomic pad may potentially allow a more effective training, prevent musculoskeletal discomfort and reduce the risk of injury. Practitioner summary: We have designed an ergonomic thorax stabilisation pad for the preacher arm curl exercise. The new ergonomic pad improves the poor posture conditions induced by the standard flat pad and may potentially allow a more effective training, prevent musculoskeletal discomfort, improve the breathing function and reduce the risk of injury.

Nutrient absorption and weight gain in persistent diarrhea: comparison of a traditional rice-lentil/yogurt/milk diet with soy formula.

PubMed

Bhutta, Z A; Molla, A M; Issani, Z; Badruddin, S; Hendricks, K; Snyder, J D

1994-01-01

We prospectively studied clinical outcome and nutrition absorption in male children (6-36 months of age) with persistent diarrhea (PD) and severe protein-energy malnutrition (mean z score for age, -4.2 +/- 0.8). Fifty-one children were randomly allocated to receive a combination of khitchri, a rice-lentil mixture, yogurt, and half-strength buffalo milk (group A; n = 26) or full-strength soy formula (group B; n = 25) for 14 days. The initial caloric intake (p < 0.02) and mean weight gain (p < 0.02) were greater in the group B patients. The mean stool volume and frequency were comparable between the two groups. Seven children in group A were considered clinical failures by criteria of weight loss and PD, compared to three in group B. The coefficients of absorption (COA) for protein were similar between the two groups, but group B patients had higher values of COA for energy and fat (p < 0.05) in the second week of nutritional rehabilitation. The majority (63%) of the children improved on the khichri-yogurt-milk diet but the nutritional outcome was not as good as with the soy formula. These data indicate that a traditional diet can be successfully used in the dietary management of PD and severe malnutrition but that a more optimal composition, yielding a higher success rate, should be sought.

Change detection with heterogeneous data using ecoregional stratification, statistical summaries and a land allocation algorithm

Treesearch

Kathleen M. Bergen; Daniel G. Brown; James F. Rutherford; Eric J. Gustafson

2005-01-01

A ca. 1980 national-scale land-cover classification based on aerial photo interpretation was combined with 2000 AVHRR satellite imagery to derive land cover and land-cover change information for forest, urban, and agriculture categories over a seven-state region in the U.S. To derive useful land-cover change data using a heterogeneous dataset and to validate our...

Providing Child Care to Military Families. The Role of the Demand Formula in Defining Need and Informing Policy

DTIC Science & Technology

2006-01-01

SECURITY POPULATION AND AGING PUBLIC SAFETY SCIENCE AND TECHNOLOGY SUBSTANCE ABUSE TERRORISM AND HOMELAND SECURITY TRANSPORTATION AND INFRASTRUCTURE...An Analysis of Current Operations and New Approaches (R-4145-FMP, 1992), examined military child-care operations prior to the implemen- tation of...in the community. DoD recently introduced a new program called “Operation: Military Child Care” that can serve as Summary xxi an example of the

An integrated measure of display clutter based on feature content, user knowledge and attention allocation factors.

PubMed

Pankok, Carl; Kaber, David B

2018-05-01

Existing measures of display clutter in the literature generally exhibit weak correlations with task performance, which limits their utility in safety-critical domains. A literature review led to formulation of an integrated display data- and user knowledge-driven measure of display clutter. A driving simulation experiment was conducted in which participants were asked to search 'high' and 'low' clutter displays for navigation information. Data-driven measures and subjective perceptions of clutter were collected along with patterns of visual attention allocation and driving performance responses during time periods in which participants searched the navigation display for information. The new integrated measure was more strongly correlated with driving performance than other, previously developed measures of clutter, particularly in the case of low-clutter displays. Integrating display data and user knowledge factors with patterns of visual attention allocation shows promise for measuring display clutter and correlation with task performance, particularly for low-clutter displays. Practitioner Summary: A novel measure of display clutter was formulated, accounting for display data content, user knowledge states and patterns of visual attention allocation. The measure was evaluated in terms of correlations with driver performance in a safety-critical driving simulation study. The measure exhibited stronger correlations with task performance than previously defined measures.

The Australasian Society of Clinical Immunology and Allergy position statement: Summary of allergy prevention in children.

PubMed

Prescott, Susan L; Tang, Mimi L K

2005-05-02

A family history of allergy and asthma identifies children at high risk of allergic disease. Dietary restrictions in pregnancy are not recommended. Avoiding inhalant allergens during pregnancy has not been shown to reduce allergic disease, and is not recommended. Breastfeeding should be recommended because of other beneficial effects, but if breast feeding is not possible, a hydrolysed formula is recommended (rather than conventional cow's milk formulas) in high-risk infants only. Maternal dietary restrictions during breastfeeding are not recommended. Soy formulas and other formulas (eg, goat's milk) are not recommended for reducing food allergy risk. Complementary foods (including normal cow's milk formulas) should be delayed until a child is aged at least 4-6 months, but a preventive effect from this measure has only been demonstrated in high-risk infants. There is no evidence that an elimination diet after age 4-6 months has a protective effect, although this needs additional investigation. Further research is needed to determine the relationship between house dust mite exposure at an early age and the development of sensitisation and disease; no recommendation can yet be made about avoidance measures for preventing allergic disease. No recommendations can be made about exposure to pets in early life and the development of allergic disease. If a family already has pets it is not necessary to remove them, unless the child develops evidence of pet allergy (as assessed by an allergy specialist). Women should be advised not to smoke while pregnant, and parents should be advised not to smoke. No recommendations can be made on the use of probiotic supplements (or other microbial agents) for preventing allergic disease at this time. Immunotherapy may be considered as a treatment option for children with allergic rhinitis, and may prevent the subsequent development of asthma.

Polydextrose enrichment of infant formula demonstrates prebiotic characteristics by altering intestinal microbiota, organic acid concentrations, and cytokine expression in suckling piglets.

PubMed

Herfel, Tina M; Jacobi, Sheila K; Lin, Xi; Fellner, Vivek; Walker, D Carey; Jouni, Zeina E; Odle, Jack

2011-12-01

Oligosaccharides, the 3rd-most abundant component in human milk, are virtually absent from infant formulas and from the cow milk on which most are based. In breast-fed infants, human milk oligosaccharides (HMO) act as both receptor analogs, interfering with pathogen adhesion, and as prebiotics, stimulating the growth of certain commensal bacteria (e.g. bifidobacteria) and supporting the innate immunity. To further align the functional properties of infant formula with those of human milk, polydextrose (PDX) is proposed as a substitute for HMO. To determine the prebiotic functionality of PDX, 1-d-old pigs were fed a cow milk-based formula supplemented with increasing concentrations of PDX (0, 1.7, 4.3, 8.5, or 17 g/L) for 18 d (n = 13). Additional reference groups included pigs sampled at d 0 and sow-reared pigs sampled at d 18 (n = 12). Ileal Lactobacilli CFU, but not Bifidobacteria, increased linearly with increasing PDX (P = 0.02). The propionic acid concentration in digesta linearly increased with the PDX level (P = 0.045) and lactic acid increased linearly by 5-fold with increasing PDX (P = 0.001). Accordingly, digesta pH decreased linearly (P < 0.05) as PDX increased, with a maximal reduction approaching 0.5 pH units in pigs fed 17 g/L. Expression of TNFα, IL-1β, and IL-8 showed a negative quadratic pattern in response to PDX supplementation, declining at intermediate concentrations and rebounding at higher concentrations of PDX. In summary, PDX enrichment of infant formula resulted in a prebiotic effect by increasing ileal lactobacilli and propionic and lactic acid concentrations and decreasing pH with associated alterations in ileal cytokine expression.

Tackling regional health inequalities in france by resource allocation : a case for complementary instrumental and process-based approaches?

PubMed

Bellanger, Martine M; Jourdain, Alain

2004-01-01

This article aims to evaluate the results of two different approaches underlying the attempts to reduce health inequalities in France. In the 'instrumental' approach, resource allocation is based on an indicator to assess the well-being or the quality of life associated with healthcare provision, the argument being that additional resources would respond to needs that could then be treated quickly and efficiently. This governs the distribution of regional hospital budgets. In the second approach, health professionals and users in a given region are involved in a consensus process to define those priorities to be included in programme formulation. This 'procedural' approach is employed in the case of the regional health programmes. In this second approach, the evaluation of the results runs parallel with an analysis of the process using Rawlsian principles, whereas the first approach is based on the classical economic model.At this stage, a pragmatic analysis based on both the comparison of regional hospital budgets during the period 1992-2003 (calculated using a 'RAWP [resource allocation working party]-like' formula) and the evolution of regional health policies through the evaluation of programmes for the prevention of suicide, alcohol-related diseases and cancers provides a partial assessment of the impact of the two types of approaches, the second having a greater effect on the reduction of regional inequalities.

75 FR 72735 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Cod by Catcher Vessels Less Than 60...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... Catcher Vessels Less Than 60 Feet (18.3 m) Length Overall Using Hook-and-Line or Pot Gear in the Bering.... SUMMARY: NMFS is prohibiting directed fishing for Pacific cod by catcher vessels less than 60 feet (18.3 m... allocated to catcher vessels less than 60 feet LOA using hook-and-line or pot gear in the BSAI. DATES...

A Summary of the Technical Pilot Selection Literature

DTIC Science & Technology

2011-10-01

assigned to one of four groups. The apparatus tests specifically were designed to assess those causes that later were listed in the “coordination...with 15 min. allocated for each test (Staff Psychological Reseach Unit #1, 1945). One of the immediate practical problems with administering the...inventory and its eventual operational use in July 1943. One test in the Aircrew Classification Battery was designed to assess timesharing--the Rotary

The Navy Enlistment Field Marketing Experiment. Volume 1. Executive Overview and Summary

DTIC Science & Technology

1982-10-15

Congress to effect changes in advertising expenditure levels and recruiter presence in selected market areas. Finally, the support and par- ticipation...cause marketing efforts. Further, marketing variables themselves may not be allocated independently of one another. Recruiting and advertising may be...treatment markets to the level and type of advertising and recruiters to which they would be exposed under the alternative budget levels being tested

Federal Support for Research and Development

DTIC Science & Technology

2007-06-01

Nonprofits State and Local Governments 0 B In recent years, the share of federal research funding allocated to the life sciences has expanded, an empha...sis supported by the high rates of returns to life sci- ences research that some studies have reported. But other studies indicate that researchers...changed over time, with the life sciences accounting for an increasing share of federal research spending since the 1990s (see Summary Figure 5

Weight losses with low-energy formula diets in obese patients with and without type 2 diabetes: systematic review and meta-analysis.

PubMed

Leslie, W S; Taylor, R; Harris, L; Lean, M E J

2017-01-01

To provide a systematic review, of published data, to compare weight losses following very low calorie (<800 kcal per day VLCD) or low-energy liquid-formula (>800 kcal per day LELD) diets, in people with and without type 2 diabetes mellitus (T2DM). Systematic electronic searches of Medline (1946-2015) and Embase (1947-2015) to identify published studies using formula total diet replacement diets (VLCD/LELD). Random effects meta-analysis using weighted mean difference (WMD) in body weight between groups (with and without diabetes) as the summary estimate. Final weight loss, in the five included studies, weighted for study sizes, (n=569, mean BMI=35.5-42.6 kg/m 2 ), was not significantly different between participants with and without T2DM: -1.2 kg; 95% CI: -4.1 to 1.6 kg). Rates of weight loss were also similar in the two groups -0.6 kg per week (T2DM) and 0.5 kg per week (no diabetes), and for VLCD (<800 kcal per day) and LELD (>800 kcal per day). Weight losses with liquid-formula diets are very similar for VLCD and LELD and for obese subjects with or without T2DM. They can potentially achieve new weight loss/ maintenance targets of >15-20% for people with severe and medically complicated obesity.

Cancer care, money, and the value of life: whose justice? Which rationality?

PubMed

Sulmasy, Daniel P

2007-01-10

Cost-containment in oncology is a moral issue. While economists use the word "rationing" to describe all limitations on resource utilization that result from human choice, the ordinary language distinction between allocation and rationing is morally meaningful and can help oncologists to determine their proper moral role in cost-containment. It is argued that oncologists should not be required to ration at the bedside, nor should they be given financial incentives to practice frugally, nor should they be subjected to a variety of bureaucratic mechanisms to control costs indirectly. In addition, it is argued that the fact that treatments have a price does not logically imply that patients have a price. Cost-effectiveness analysis is often suggested as a means of deciding how best to allocate resources, but some of its many ethical limitations are discussed. The alternative is an open, public, participatory process about how to ration care, abandoning the formulaic pretenses of cost-effectiveness analysis, but with a commitment to reason, good will, and common sense. Oncologists would then be free to advocate for their patients within the constraints imposed by this public process.

Fagaceae tree species allocate higher fraction of nitrogen to photosynthetic apparatus than Leguminosae in Jianfengling tropical montane rain forest, China

PubMed Central

Cheng, Ruimei; Shi, Zuomin; Xu, Gexi; Liu, Shirong; Centritto, Mauro

2018-01-01

Variation in photosynthetic-nitrogen use efficiency (PNUE) is generally affected by several factors such as leaf nitrogen allocation and leaf diffusional conductances to CO2, although it is still unclear which factors significantly affect PNUE in tropical montane rain forest trees. In this study, comparison of PNUE, photosynthetic capacity, leaf nitrogen allocation, and diffusional conductances to CO2 between five Fagaceae tree species and five Leguminosae tree species were analyzed in Jianfengling tropical montane rain forest, Hainan Island, China. The result showed that PNUE of Fagaceae was significantly higher than that of Leguminosae (+35.5%), attributed to lower leaf nitrogen content per area (Narea, –29.4%). The difference in nitrogen allocation was the main biochemical factor that influenced interspecific variation in PNUE of these tree species. Fagaceae species allocated a higher fraction of leaf nitrogen to the photosynthetic apparatus (PP, +43.8%), especially to Rubisco (PR, +50.0%) and bioenergetics (PB +33.3%) in comparison with Leguminosae species. Leaf mass per area (LMA) of Leguminosae species was lower than that of Fagaceae species (-15.4%). While there was no significant difference shown for mesophyll conductance (gm), Fagaceae tree species may have greater chloroplast to total leaf surface area ratios and that offset the action of thicker cell walls on gm. Furthermore, weak negative relationship between nitrogen allocation in cell walls and in Rubisco was found for Castanopsis hystrix, Cyclobalanopsis phanera and Cy. patelliformis, which might imply that nitrogen in the leaves was insufficient for both Rubisco and cell walls. In summary, our study concluded that higher PNUE might contribute to the dominance of most Fagaceae tree species in Jianfengling tropical montane rain forest. PMID:29390007

Fagaceae tree species allocate higher fraction of nitrogen to photosynthetic apparatus than Leguminosae in Jianfengling tropical montane rain forest, China.

PubMed

Tang, Jingchao; Cheng, Ruimei; Shi, Zuomin; Xu, Gexi; Liu, Shirong; Centritto, Mauro

2018-01-01

Variation in photosynthetic-nitrogen use efficiency (PNUE) is generally affected by several factors such as leaf nitrogen allocation and leaf diffusional conductances to CO2, although it is still unclear which factors significantly affect PNUE in tropical montane rain forest trees. In this study, comparison of PNUE, photosynthetic capacity, leaf nitrogen allocation, and diffusional conductances to CO2 between five Fagaceae tree species and five Leguminosae tree species were analyzed in Jianfengling tropical montane rain forest, Hainan Island, China. The result showed that PNUE of Fagaceae was significantly higher than that of Leguminosae (+35.5%), attributed to lower leaf nitrogen content per area (Narea, -29.4%). The difference in nitrogen allocation was the main biochemical factor that influenced interspecific variation in PNUE of these tree species. Fagaceae species allocated a higher fraction of leaf nitrogen to the photosynthetic apparatus (PP, +43.8%), especially to Rubisco (PR, +50.0%) and bioenergetics (PB +33.3%) in comparison with Leguminosae species. Leaf mass per area (LMA) of Leguminosae species was lower than that of Fagaceae species (-15.4%). While there was no significant difference shown for mesophyll conductance (gm), Fagaceae tree species may have greater chloroplast to total leaf surface area ratios and that offset the action of thicker cell walls on gm. Furthermore, weak negative relationship between nitrogen allocation in cell walls and in Rubisco was found for Castanopsis hystrix, Cyclobalanopsis phanera and Cy. patelliformis, which might imply that nitrogen in the leaves was insufficient for both Rubisco and cell walls. In summary, our study concluded that higher PNUE might contribute to the dominance of most Fagaceae tree species in Jianfengling tropical montane rain forest.

Optimal Power Allocation for Downstream xDSL With Per-Modem Total Power Constraints: Broadcast Channel Optimal Spectrum Balancing (BC-OSB)

NASA Astrophysics Data System (ADS)

Le Nir, Vincent; Moonen, Marc; Verlinden, Jan; Guenach, Mamoun

2009-02-01

Recently, the duality between Multiple Input Multiple Output (MIMO) Multiple Access Channels (MAC) and MIMO Broadcast Channels (BC) has been established under a total power constraint. The same set of rates for MAC can be achieved in BC exploiting the MAC-BC duality formulas while preserving the total power constraint. In this paper, we describe the BC optimal power allo- cation applying this duality in a downstream x-Digital Subscriber Lines (xDSL) context under a total power constraint for all modems over all tones. Then, a new algorithm called BC-Optimal Spectrum Balancing (BC-OSB) is devised for a more realistic power allocation under per-modem total power constraints. The capacity region of the primal BC problem under per-modem total power constraints is found by the dual optimization problem for the BC under per-modem total power constraints which can be rewritten as a dual optimization problem in the MAC by means of a precoder matrix based on the Lagrange multipliers. We show that the duality gap between the two problems is zero. The multi-user power allocation problem has been solved for interference channels and MAC using the OSB algorithm. In this paper we solve the problem of multi-user power allocation for the BC case using the OSB algorithm as well and we derive a computational efficient algorithm that will be referred to as BC-OSB. Simulation results are provided for two VDSL2 scenarios: the first one with Differential-Mode (DM) transmission only and the second one with both DM and Phantom- Mode (PM) transmissions.

Performance Data Gathering and Representation from Fixed-Size Statistical Data

NASA Technical Reports Server (NTRS)

Yan, Jerry C.; Jin, Haoqiang H.; Schmidt, Melisa A.; Kutler, Paul (Technical Monitor)

1997-01-01

The two commonly-used performance data types in the super-computing community, statistics and event traces, are discussed and compared. Statistical data are much more compact but lack the probative power event traces offer. Event traces, on the other hand, are unbounded and can easily fill up the entire file system during program execution. In this paper, we propose an innovative methodology for performance data gathering and representation that offers a middle ground. Two basic ideas are employed: the use of averages to replace recording data for each instance and 'formulae' to represent sequences associated with communication and control flow. The user can trade off tracing overhead, trace data size with data quality incrementally. In other words, the user will be able to limit the amount of trace data collected and, at the same time, carry out some of the analysis event traces offer using space-time views. With the help of a few simple examples, we illustrate the use of these techniques in performance tuning and compare the quality of the traces we collected with event traces. We found that the trace files thus obtained are, indeed, small, bounded and predictable before program execution, and that the quality of the space-time views generated from these statistical data are excellent. Furthermore, experimental results showed that the formulae proposed were able to capture all the sequences associated with 11 of the 15 applications tested. The performance of the formulae can be incrementally improved by allocating more memory at runtime to learn longer sequences.

Compound Formulas of Traditional Chinese Medicine for the Common Cold: Systematic Review of Randomized, Placebo-controlled Trials.

PubMed

Li, Guanhong; Cai, Linli; Jiang, Hongli; Dong, Shoujin; Fan, Tao; Liu, Wei; Xie, Li; Mao, Bing

2015-01-01

The common cold is one of the most frequent acute illnesses of the respiratory tract, affecting all age groups. The compound formulas of traditional Chinese medicine (TCM) are frequently used to treat the common cold in China and other parts of the world. Until now, however, the efficacy and safety of compound formulas of TCM for the common cold, studied in comparison with placebos, have not been systematically reviewed. This literature review intended to assess existing evidence of the effectiveness and safety of compound formulas of TCM for the common cold. Randomized, controlled trials (RCTs) comparing compound formulas of TCM with placebos in treating the common cold were included, regardless of publication status. The research team searched the Cochrane Library, PubMed, Embase, the Chinese Biomedical Literature Database, the Chinese Scientific and Technological Periodical Database, the Chinese National Knowledge Infrastructure and the Wangfang Database from their inceptions to December 2013. The team also searched Web sites listing ongoing trials and contacted experts in the field and relevant pharmaceutical companies to locate unpublished materials. Two review authors independently extracted data and assessed the methodological quality of included studies, using the Cochrane risk of bias tool. A total of 6 randomized, double-blind, placebo-controlled trials involving 1502 participants were included. Most trials had a low risk of bias. Five were conducted in mainland China and 1 in Hong Kong; 5 were multicenter clinical trials and 1 was a single-center trial; 4 were published in Chinese and 2 were published in English. Compound formulas of TCM were superior to placebos in reducing disease symptoms, inducing recovery from a TCM syndrome, and increasing quality of life. In addition, the formulas were superior in shortening the duration of the main symptoms, the amount of time for a decline in temperature of at least 0.5°C to occur, and the duration of any fever. The team did not perform a summary meta-analysis due to clinical heterogeneity. No serious adverse event (AE) occurred in either the treatment or the control groups. This systematic review indicated that compound formulas of TCM, compared with placebo, can provide benefits to patients with the common cold, with no serious side effects having been identified in the included trials. However, due to the small number of included studies and of participants and the unclear risk of some biases in the included studies, more high-quality, large-scale RCTs are still warranted to clarify fully the effectiveness and safety of compound formulas of TCM in treating the common cold.

UTD at TREC 2014: Query Expansion for Clinical Decision Support

DTIC Science & Technology

2014-11-01

Description: A 62-year-old man sees a neurologist for progressive memory loss and jerking movements of the lower ex- tremities. Neurologic examination confirms...infiltration. Summary: 62-year-old man with progressive memory loss and in- voluntary leg movements. Brain MRI reveals cortical atrophy, and cortical...latent topics produced by the Latent Dirichlet Allocation (LDA) on the TREC-CDS corpus of scientific articles. The position of words “ loss ” and “ memory

77 FR 55735 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Cod in the Bering Sea and Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... closure. SUMMARY: NMFS is opening directed fishing for Pacific cod by catcher vessels less than 60 feet... Pacific cod allocated to catcher vessels less than 60 feet LOA using hook-and-line or pot gear in the BSAI... vessels less than 60 feet LOA using hook-and-line or pot gear in the BSAI under Sec. 679.20(d)(1)(iii) on...

76 FR 24404 - Fisheries of the Exclusive Economic Zone Off Alaska; Pacific Cod in the Bering Sea and Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

... closure. SUMMARY: NMFS is opening directed fishing for Pacific cod by catcher vessels less than 60 feet... Pacific cod allocated to catcher vessels less than 60 feet LOA using hook-and-line or pot gear in the BSAI... less than 60 feet LOA using hook-and-line or pot gear in the BSAI under Sec. 679.20(d)(1)(iii) on March...

Overhead Allocation and Incentives for Cost Minimization in Defense Procurement

DTIC Science & Technology

1992-01-01

Staff. The publication should be of interest to researchers and policymakers who are concerned about the effects of profit policy and cost - account ...ing regulations on business incentives, system costs , and contractor profits. A shorter version of this report has appeared in The Accounting Re- view... Accounting Review. ii SUMMARY Defense firms typically produce a large number of products and it is often difficult to keep track of the cost of producing

Financing Postsecondary Education: The Federal Role. Proceedings of the National Conference on the Best Ways for the Federal Government To Help Students and Families Finance Postsecondary Education (Charleston, South Carolina, October 8-9, 1995).

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

This conference proceedings provides a summary of a conference on the federal role in the financing of postsecondary education, along with nine papers commissioned for the conference. The papers include: (1) "The Federal Role in Financing Higher Education: An Economic Perspective" (Sandy Baum); (2) "Rethinking the Allocation of Pell…

Impact of 60 days of 6° head down tilt bed rest on muscular oxygen uptake and heart rate kinetics: efficacy of a reactive sledge jump countermeasure.

PubMed

Koschate, J; Thieschäfer, L; Drescher, U; Hoffmann, U

2018-06-26

The effects of 60 days of head down tilt bed rest (HDBR) with and without the application of a reactive jump countermeasure were investigated, using a method which enables to discriminate between pulmonary ([Formula: see text]O 2 pulm) and muscular ([Formula: see text]O 2 musc) oxygen uptake kinetics to control for hemodynamic influences. 22 subjects were randomly allocated to either a group performing a reactive jumps countermeasure (JUMP; n = 11, male, 29 ± 7 years, 23.9 ± 1.3 kg m - 2 ) or a control group (CTRL; n = 11, male, 29 ± 6 years, 23.3 ± 2.0 kg m - 2 ). Heart rate (HR) and [Formula: see text]O 2 pulm were measured in response to repeated changes in work rate between 30 and 80 W before (BDC-9) and two times after HDBR (R+ 2, R+ 13). Kinetic responses of HR, [Formula: see text]O 2 pulm, and [Formula: see text]O 2 musc were assessed applying time series analysis. Higher maxima in cross-correlation functions (CCF max (x)) between work rate and the respective parameter indicate faster kinetics responses. Statistical analysis was performed applying multifactorial analysis of variance. CCF max ([Formula: see text]O 2 musc) and CCF max ([Formula: see text]O 2 pulm) were not significantly different before and after HDBR (P > 0.05). CCF max (HR) decreased following bed rest (JUMP: BDC-9: 0.30 ± 0.09 vs. R+ 2: 0.28 ± 0.06 vs. R+13: 0.28 ± 0.07; CTRL: 0.35 ± 0.09 vs. 0.27 ± 0.06 vs. 0.33 ± 0.07 P = 0.025). No significant differences between the groups were observed (P > 0.05). Significant alterations were found for CCF max of mean arterial blood pressure (mBP) after HDBR (JUMP: BDC-9: 0.21 ± 0.07 vs. R+ 2: 0.30 ± 0.13 vs. R+ 13: 0.28 ± 0.08; CTRL: 0.25 ± 0.07 vs. 0.38 ± 0.13 vs. 0.28 ± 0.08; P = 0.008). Despite hemodynamic changes, [Formula: see text]O 2 kinetics seem to be preserved for a longer period of HDBR, even without the application of a countermeasure.

CREB regulates memory allocation in the insular cortex

PubMed Central

Sano, Yoshitake; Shobe, Justin L.; Zhou, Miou; Huang, Shan; Shuman, Tristan; Cai, Denise J.; Golshani, Peyman; Kamata, Masakazu; Silva, Alcino J.

2016-01-01

Summary The molecular and cellular mechanisms of memory storage have attracted a great deal of attention. By comparison, little is known about memory allocation, the process that determines which specific neurons in a neural network will store a given memory [1, 2]. Previous studies demonstrated that memory allocation is not random in the amygdala; these studies showed that amygdala neurons with higher levels of the cAMP response element binding protein (CREB) are more likely to be recruited into encoding and storing fear memory [3–6]. To determine whether specific mechanisms also regulate memory allocation in other brain regions, and whether CREB also has a role in this process, we studied insular cortical memory representations for conditioned taste aversion (CTA). In this task, an animal learns to associate a taste (CS) with the experience of malaise (such as that induced by LiCl; US). The insular cortex is required for CTA memory formation and retrieval [7–12]. CTA learning activates a subpopulation of neurons in this structure [13–15], and the insular cortex and the basolateral amygdala (BLA) interact during CTA formation [16, 17]. Here, we used a combination of approaches, including viral vector transfections of insular cortex, arc Fluorescence In Situ Hybridization (FISH) and Designer Receptors Exclusively Activated by Designer Drugs (DREADD) system, to show that CREB levels determine which insular cortical neurons go on to encode a given conditioned taste memory. PMID:25454591

Verification of Java Programs using Symbolic Execution and Invariant Generation

NASA Technical Reports Server (NTRS)

Pasareanu, Corina; Visser, Willem

2004-01-01

Software verification is recognized as an important and difficult problem. We present a norel framework, based on symbolic execution, for the automated verification of software. The framework uses annotations in the form of method specifications an3 loop invariants. We present a novel iterative technique that uses invariant strengthening and approximation for discovering these loop invariants automatically. The technique handles different types of data (e.g. boolean and numeric constraints, dynamically allocated structures and arrays) and it allows for checking universally quantified formulas. Our framework is built on top of the Java PathFinder model checking toolset and it was used for the verification of several non-trivial Java programs.

Australian governments' spending on preventing and responding to drug abuse should target the main sources of drug-related harm and the most cost-effective interventions.

PubMed

McDonald, David

2011-01-01

A notable feature of Australian drug policy is the limited public and professional attention given to the financial costs of drug abuse and to the levels and patterns of government expenditures incurred in preventing and responding to this. Since 1991, Collins and Lapsley have published scholarly reports documenting the social costs of drug abuse in Australia and their reports also contain estimates of governments' drug budgets: revenue and expenditures. They show that, in 2004-2005, Australian governments expended at least $5288 million on drug abuse, with 50% of the expenditure directed to preventing and dealing with alcohol-related problems, 45% to illicit drugs and just 5% to tobacco. Some 60% of the expenditure was directed at drug crime and 37% at health interventions. This pattern of resource allocation does not adequately reflect an evidence-informed policy orientation in that it largely fails to focus on the drug types that are the sources of the most harm (tobacco and alcohol rather than illicit drugs), and the sectors for which we have the strongest evidence of the cost-effectiveness of the available interventions (treatment and harm reduction rather than legislation and law enforcement). The 2010-2014 phase of Australia's National Drug Strategy should include incremental changes to the resource allocation mix, and not simply maintain the historical resource allocation formulae. © 2010 Australasian Professional Society on Alcohol and other Drugs.

Impact of socioeconomic factors on in-patient length of stay and their consequences in per case hospital payment systems.

PubMed

Perelman, Julian; Closon, Marie-Christine

2011-10-01

The number of countries adopting per case hospital payment systems has been continuously increasing in recent years. Nonetheless, debates persist regarding their consequences for equity of access to services. This concern relates to the failure of diagnostic classifications properly to take into account patients' care requirements, raising the threat of case selection ('cream skimming'). We examine the heterogeneity of costs within diagnostic categories related to socioeconomic (SE) factors using length of stay (LOS) as a proxy measure of care needs and costs. We evaluate its consequences in terms of fairness in resource allocation between hospitals. We employ data on all discharges in 2002-03 from a sample of 60 Belgian hospitals (617,275 observations), measuring the association between LOS and SE factors using generalized linear models. We design a resource allocation formula based on the Belgian financing scheme, where non-medical activity is paid based on a normative number of in-patient days, and measure financial penalties and rewards according to whether payment is adjusted for the SE characteristics of patients or not. Both patients' SE status and hospitals' area SE profile have a significant impact on LOS, which persists after controlling for detailed diagnostic and hospital characteristics. Hospitals treating low income patients are financially penalized as a result. SE factors are a predictor of in-patient LOS and should be taken into account in per case resource allocation among hospitals.

New Methods for the Analysis of Fat-Soluble Vitamins in Infant Formula and Adult Nutritionals.

PubMed

Gilliland, Don

2016-01-01

The AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) defined fat-soluble vitamins (FSVs) to include vitamins A, D, E, and K. The levels of FSVs have been closely scrutinized because of a number of factors, including nutrition value especially in foods used to provide sole-source nutrition and the potential for health risks associated with content both below and above recommended levels. Stricter scrutiny and emphasis on nutrient-level compliance with regulatory requirements placed an increased demand on analytical methods that were fit-for-purpose, provided accurate and precise results. Over time, compendial methods have been developed and published by organizations such as AOAC INTERNATIONAL, the European Committee for Standardization, the International Dairy Federation, and the International Organization for Standardization, among others. In general, these methods have shown adequate precision for regulatory compliance based on example food matrixes for which they were designed. However, method evaluation for infant formulas and adult nutritional products was limited to very few matrixes within these categories. As such, method applicability gaps were noted and correlated with more complicated or diverse product matrixes. AOAC undertook the task of modernizing test methods for the determination of nutrients in infant formulas and in adult nutritional products formulated specifically for both healthy adults and those requiring specific nutritional intake. Composition of products in this category continued to evolve, which in turn presented increasing and new challenges to analytical methodology. A summary of a new generation of candidate compendial methods for determination of FSVs in these matrixes, identified by SPIFAN, is presented here.

Enterobacter sakazakii in food and beverages (other than infant formula and milk powder).

PubMed

Friedemann, Miriam

2007-05-01

The ubiqitous microorganism Enterobacter sakazakii is a rare contaminant of infant formula and may cause severe systemic infection in neonates. So far, other food is not known to cause E. sakazakii-infections. The scarce information about the ecology of E. sakazakii and the uncertainty concerning the source of infection in children and adults warrant a summary of the current knowledge about the presence of this opportunistic microorganism in food other than infant formula. This review systematizes publications on the presence of E. sakazakii in food and beverages until June 2006. Food other than infant formula has been rarely investigated for the presence of E. sakazakii. Nevertheless, this microorganism could be isolated from a wide spectrum of food and food ingredients. E. sakazakii was isolated from plant food and food ingredients like cereal, fruit and vegetables, legume products, herbs and spices as well as from animal food sources like milk, meat and fish and products made from these foods. The spectrum of E. sakazakii-contaminated food covers both raw and processed food. The kind of processing of E. sakazakii-contaminated food was not restricted to dry products. Fresh, frozen, ready-to-eat, fermented and cooked food products as well as beverages and water suitable for the preparation of food, were found to be contaminated by E. sakazakii. Although E. sakazakii-contaminated food do not have general public health significance, measures for prevention should consider the presence of E. sakazakii in food, food ingredients, their processing and preparation as possible source of contamination, colonization or infection.

Parallel Systems Laboratory: Access, Allocation, and Control

DTIC Science & Technology

1992-06-30

boog Eae...4d READ ISTRUCTIONSREPORT DOCUMENTATIO PAGE BEFOR COMPLETNG FORM I. REPORT NUMNER 2. GOVT ACCESSION NO 3- RECIPINT’S CATALOG NUMR9 . TITLE (an...a summary of the salient results of this research in capsule form which is followed by an extensive list of publications, dissertations and theses...because it provides the asymptotic use of currently wasted cycles. To do so, we examine a distribution of w(u It) in a very simple form and for

Nonparametric estimation of the multivariate survivor function: the multivariate Kaplan-Meier estimator.

PubMed

Prentice, Ross L; Zhao, Shanshan

2018-01-01

The Dabrowska (Ann Stat 16:1475-1489, 1988) product integral representation of the multivariate survivor function is extended, leading to a nonparametric survivor function estimator for an arbitrary number of failure time variates that has a simple recursive formula for its calculation. Empirical process methods are used to sketch proofs for this estimator's strong consistency and weak convergence properties. Summary measures of pairwise and higher-order dependencies are also defined and nonparametrically estimated. Simulation evaluation is given for the special case of three failure time variates.

The Effect of Low-Carbohydrate Diet on Glycemic Control in Patients with Type 2 Diabetes Mellitus.

PubMed

Wang, Li-Li; Wang, Qi; Hong, Yong; Ojo, Omorogieva; Jiang, Qing; Hou, Yun-Ying; Huang, Yu-Hua; Wang, Xiao-Hua

2018-05-23

In China, a low-fat diet (LFD) is mainly recommended to help improve blood glucose levels in patients with type 2 diabetes mellitus (T2DM). However, a low-carbohydrate diet (LCD) has been shown to be effective in improving blood glucose levels in America and England. A few studies, primarily randomized controlled trials, have been reported in China as well. Firstly, we designed two 'six-point formula' methods, which met the requirements of LCD and LFD, respectively. Fifty-six T2DM patients were recruited and randomly allocated to the LCD group ( n = 28) and the LFD group ( n = 28). The LCD group received education about LCD's six-point formula, while the LFD group received education about LFD's six-point formula. The follow-up time was three months. The indicators for glycemic control and other metabolic parameters were collected and compared between the two groups. Forty-nine patients completed the study. The proportions of calories from three macronutrients the patients consumed met the requirements of LCD and LFD. Compared to the LFD group, there was a greater decrease in HbA1c level in the LCD group (-0.63% vs. -0.31%, p < 0.05). The dosages of insulin and fasting blood glucoses (FBG) in the third month were lower than those at baseline in both groups. Compared with baseline values, body mass index (BMI) and total cholesterol (TC) in the LCD group were significantly reduced in the third month ( p < 0.05); however, there were no statistically significant differences in the LFD group. LCD can improve blood glucose more than LFD in Chinese patients with T2DM. It can also regulate blood lipid, reduce BMI, and decrease insulin dose in patients with T2DM. In addition, the six-point formula is feasible, easily operable, and a practical educational diet for Chinese patients with T2DM.

Determination of Five Chemical Markers in DF Formula, the Herbal Composition of Ephedra intermedia, Rheum palmatum, and Lithospermum erythrorhizon, Using High-performance Liquid Chromatography-ultraviolet Detection

PubMed Central

Jeong, Birang; Roh, Jong Seong; Yoon, Michung; Yoon, Yoosik; Shin, Soon Shik; Cho, Hyun Joo; Kwon, Yong Soo; Yang, Heejung

2018-01-01

Background: DF formula is a herbal preparation comprised three medicinal herbs, namely, Ephedra intermedia, Rheum palmatum, and Lithospermum erythrorhizon, which is being used for the treatment of obesity and liver fibrosis in Korean local clinics. Objective: Since the abovementioned three herbs exist with different proportions in DF formula and their chemical markers have different physiochemical properties; it is quite challenging to develop an analytical methodology for the determination of these chemical markers. Materials and Methods: For the analysis of the three herbs, five chemicals, (+)-pseudoephedrine (1) and (−)-ephedrine (2) for E. intermedia, aloe-emodin (3), and chrysophanol (4) for R. palmatum, and shikonin (5) for L. erythrorhizon, were selected for method validation of DF formula, and the analytical conditions were optimized and validated using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC-UV). Results: The specificities for the five compounds 1–5 were determined by their UV absorption spectra (1–4: 215 nm and 5: 520 nm). Their calibration curves showed good linear regressions with high correlation coefficient values (R2 > 0.9997). The limits of detection of these five markers were in the range 0.4–2.1 ng/mL, with the exception of 5 (12.7 ng/mL). The intraday variability for all the chemical markers was less than a Relative standard deviation (RSD) of 3%, except for 5 (RSD = 12.6%). In the case of interday analysis, 1 (1.0%), 2 (3.1%), and 4 (3.7%) showed much lower variabilities (RSD < 5%) than 3 (7.6%) and 5 (8.2%). Moreover, the five chemical markers showed good recoveries with good accuracies in the range of 90%–110%. Conclusions: The developed HPLC-UV method for the determination of the five chemical markers of the components of DF formula was validated. SUMMARY DF formula, the herbal composition of Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizonFive chemical markers in DF formula were (+)-pseudoephedrine (1) and (-)-ephedrine (2) for E. intermedia, aloe-emodin (3) and chrysopanol (4) for R. palmatum, and shikonin (5) for L. erythrorhizon, with quite different physico-chemical propertiesFive chemical markers in DF formula were determined by HPLC-UV Abbreviations used: EP: (−)-ephedrine; PSEP: (+)-pseudoephedrine; HPLC: High-performance liquid chromatography; UV: Ultraviolet; LOD: Limit of detection; LOQ: Limit of quantification; RSD: Relative standard deviation. PMID:29720825

Machine learning based Intelligent cognitive network using fog computing

NASA Astrophysics Data System (ADS)

Lu, Jingyang; Li, Lun; Chen, Genshe; Shen, Dan; Pham, Khanh; Blasch, Erik

2017-05-01

In this paper, a Cognitive Radio Network (CRN) based on artificial intelligence is proposed to distribute the limited radio spectrum resources more efficiently. The CRN framework can analyze the time-sensitive signal data close to the signal source using fog computing with different types of machine learning techniques. Depending on the computational capabilities of the fog nodes, different features and machine learning techniques are chosen to optimize spectrum allocation. Also, the computing nodes send the periodic signal summary which is much smaller than the original signal to the cloud so that the overall system spectrum source allocation strategies are dynamically updated. Applying fog computing, the system is more adaptive to the local environment and robust to spectrum changes. As most of the signal data is processed at the fog level, it further strengthens the system security by reducing the communication burden of the communications network.

The Lunar Sample Compendium

NASA Technical Reports Server (NTRS)

Meyer, Charles

2009-01-01

The Lunar Sample Compendium is a succinct summary of the data obtained from 40 years of study of Apollo and Luna samples of the Moon. Basic petrographic, chemical and age information is compiled, sample-by-sample, in the form of an advanced catalog in order to provide a basic description of each sample. The LSC can be found online using Google. The initial allocation of lunar samples was done sparingly, because it was realized that scientific techniques would improve over the years and new questions would be formulated. The LSC is important because it enables scientists to select samples within the context of the work that has already been done and facilitates better review of proposed allocations. It also provides back up material for public displays, captures information found only in abstracts, grey literature and curatorial databases and serves as a ready access to the now-vast scientific literature.

Metabolism, growth, and the energetic definition of fitness: a quantitative genetic study in the land snail Cornu aspersum.

PubMed

Bruning, Andrea; Gaitán-Espitia, Juan Diego; González, Avia; Bartheld, José Luis; Nespolo, Roberto F

2013-01-01

Life-history evolution-the way organisms allocate time and energy to reproduction, survival, and growth-is a central question in evolutionary biology. One of its main tenets, the allocation principle, predicts that selection will reduce energy costs of maintenance in order to divert energy to survival and reproduction. The empirical support for this principle is the existence of a negative relationship between fitness and metabolic rate, which has been observed in some ectotherms. In juvenile animals, a key function affecting fitness is growth rate, since fast growers will reproduce sooner and maximize survival. In principle, design constraints dictate that growth rate cannot be reduced without affecting maintenance costs. Hence, it is predicted that juveniles will show a positive relationship between fitness (growth rate) and metabolic rate, contrarily to what has been observed in adults. Here we explored this problem using land snails (Cornu aspersum). We estimated the additive genetic variance-covariance matrix for growth and standard metabolic rate (SMR; rate of CO2 production) using 34 half-sibling families. We measured eggs, hatchlings, and juveniles in 208 offspring that were isolated right after egg laying (i.e., minimizing maternal and common environmental variance). Surprisingly, our results showed that additive genetic effects (narrow-sense heritabilities, h(2)) and additive genetic correlations (rG) were small and nonsignificant. However, the nonadditive proportion of phenotypic variances and correlations (rC) were unexpectedly large and significant. In fact, nonadditive genetic effects were positive for growth rate and SMR ([Formula: see text]; [Formula: see text]), supporting the idea that fitness (growth rate) cannot be maximized without incurring maintenance costs. Large nonadditive genetic variances could result as a consequence of selection eroding the additive genetic component, which suggests that past selection could have produced nonadditive genetic correlation. It is predicted that this correlation is reduced when adulthood is attained and selection starts to promote the reduction in metabolic rate.

Activity-based differentiation of pathologists' workload in surgical pathology.

PubMed

Meijer, G A; Oudejans, J J; Koevoets, J J M; Meijer, C J L M

2009-06-01

Adequate budget control in pathology practice requires accurate allocation of resources. Any changes in types and numbers of specimens handled or protocols used will directly affect the pathologists' workload and consequently the allocation of resources. The aim of the present study was to develop a model for measuring the pathologists' workload that can take into account the changes mentioned above. The diagnostic process was analyzed and broken up into separate activities. The time needed to perform these activities was measured. Based on linear regression analysis, for each activity, the time needed was calculated as a function of the number of slides or blocks involved. The total pathologists' time required for a range of specimens was calculated based on standard protocols and validated by comparing to actually measured workload. Cutting up, microscopic procedures and dictating turned out to be highly correlated to number of blocks and/or slides per specimen. Calculated workload per type of specimen was significantly correlated to the actually measured workload. Modeling pathologists' workload based on formulas that calculate workload per type of specimen as a function of the number of blocks and slides provides a basis for a comprehensive, yet flexible, activity-based costing system for pathology.

Load Balancing in Hypergraphs

NASA Astrophysics Data System (ADS)

Delgosha, Payam; Anantharam, Venkat

2018-03-01

Consider a simple locally finite hypergraph on a countable vertex set, where each edge represents one unit of load which should be distributed among the vertices defining the edge. An allocation of load is called balanced if load cannot be moved from a vertex to another that is carrying less load. We analyze the properties of balanced allocations of load. We extend the concept of balancedness from finite hypergraphs to their local weak limits in the sense of Benjamini and Schramm (Electron J Probab 6(23):13, 2001) and Aldous and Steele (in: Probability on discrete structures. Springer, Berlin, pp 1-72, 2004). To do this, we define a notion of unimodularity for hypergraphs which could be considered an extension of unimodularity in graphs. We give a variational formula for the balanced load distribution and, in particular, we characterize it in the special case of unimodular hypergraph Galton-Watson processes. Moreover, we prove the convergence of the maximum load under some conditions. Our work is an extension to hypergraphs of Anantharam and Salez (Ann Appl Probab 26(1):305-327, 2016), which considered load balancing in graphs, and is aimed at more comprehensively resolving conjectures of Hajek (IEEE Trans Inf Theory 36(6):1398-1414, 1990).

Biomass Allocation Patterns across China’s Terrestrial Biomes

PubMed Central

Wang, Limei; Li, Longhui; Chen, Xi; Tian, Xin; Wang, Xiaoke; Luo, Geping

2014-01-01

Root to shoot ratio (RS) is commonly used to describe the biomass allocation between below- and aboveground parts of plants. Determining the key factors influencing RS and interpreting the relationship between RS and environmental factors is important for biological and ecological research. In this study, we compiled 2088 pairs of root and shoot biomass data across China’s terrestrial biomes to examine variations in the RS and its responses to biotic and abiotic factors including vegetation type, soil texture, climatic variables, and stand age. The median value of RS (RSm) for grasslands, shrublands, and forests was 6.0, 0.73, and 0.23, respectively. The range of RS was considerably wide for each vegetation type. RS values for all three major vegetation types were found to be significantly correlated to mean annual precipitation (MAP) and potential water deficit index (PWDI). Mean annual temperature (MAT) also significantly affect the RS for forests and grasslands. Soil texture and forest origin altered the response of RS to climatic factors as well. An allometric formula could be used to well quantify the relationship between aboveground and belowground biomass, although each vegetation type had its own inherent allometric relationship. PMID:24710503

Physical activity for osteoarthritis management: a randomized controlled clinical trial evaluating hydrotherapy or Tai Chi classes.

PubMed

Fransen, Marlene; Nairn, Lillias; Winstanley, Julie; Lam, Paul; Edmonds, John

2007-04-15

To determine whether Tai Chi or hydrotherapy classes for individuals with chronic symptomatic hip or knee osteoarthritis (OA) result in measurable clinical benefits. A randomized controlled trial was conducted among 152 older persons with chronic symptomatic hip or knee OA. Participants were randomly allocated for 12 weeks to hydrotherapy classes (n = 55), Tai Chi classes (n = 56), or a waiting list control group (n = 41). Outcomes were assessed 12 and 24 weeks after randomization and included pain and physical function (Western Ontario and McMaster Universities Osteoarthritis Index), general health status (Medical Outcomes Study Short Form 12 Health Survey [SF-12], version 2), psychological well-being, and physical performance (Up and Go test, 50-foot walk time, timed stair climb). At 12 weeks, compared with controls, participants allocated to hydrotherapy classes demonstrated mean improvements (95% confidence interval) of 6.5 (0.4, 12.7) and 10.5 (3.6, 14.5) for pain and physical function scores (range 0-100), respectively, whereas participants allocated to Tai Chi classes demonstrated improvements of 5.2 (-0.8, 11.1) and 9.7 (2.8, 16.7), respectively. Both class allocations achieved significant improvements in the SF-12 physical component summary score, but only allocation to hydrotherapy achieved significant improvements in the physical performance measures. All significant improvements were sustained at 24 weeks. In this almost exclusively white sample, class attendance was higher for hydrotherapy, with 81% attending at least half of the available 24 classes, compared with 61% for Tai Chi. Access to either hydrotherapy or Tai Chi classes can provide large and sustained improvements in physical function for many older, sedentary individuals with chronic hip or knee OA.

Review of Particle Physics

NASA Astrophysics Data System (ADS)

Patrignani, C.; Particle Data Group

2016-10-01

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group (http://pdg.lbl.gov). The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. Contents Abstract, Contributors, Highlights and Table of ContentsAcrobat PDF (150 KB) IntroductionAcrobat PDF (456 KB) Particle Physics Summary Tables Gauge and Higgs bosonsAcrobat PDF (155 KB) LeptonsAcrobat PDF (134 KB) QuarksAcrobat PDF (84 KB) MesonsAcrobat PDF (871 KB) BaryonsAcrobat PDF (300 KB) Searches (Supersymmetry, Compositeness, etc.)Acrobat PDF (91 KB) Tests of conservation lawsAcrobat PDF (330 KB) Reviews, Tables, and Plots Detailed contents for this sectionAcrobat PDF (37 KB) Constants, Units, Atomic and Nuclear PropertiesAcrobat PDF (278 KB) Standard Model and Related TopicsAcrobat PDF (7.3 MB) Astrophysics and CosmologyAcrobat PDF (2.7 MB) Experimental Methods and CollidersAcrobat PDF (3.8 MB) Mathematical Tools or Statistics, Monte Carlo, Group Theory Acrobat PDF (1.3 MB) Kinematics, Cross-Section Formulae, and PlotsAcrobat PDF (3.9 MB) Particle Listings Illustrative key and abbreviationsAcrobat PDF (235 KB) Gauge and Higgs bosonsAcrobat PDF (2 MB) LeptonsAcrobat PDF (1.5 MB) QuarksAcrobat PDF (1.2 MB) Mesons: Light unflavored and strangeAcrobat PDF (4 MB) Mesons: Charmed and bottomAcrobat PDF (7.4 MB) Mesons: OtherAcrobat PDF (3.1 MB) BaryonsAcrobat PDF (3.97 MB) Miscellaneous searchesAcrobat PDF (2.4 MB) IndexAcrobat PDF (160 KB)

Ada Compiler Validation Summary Report: Certificate Number: 890409W1. 10063, TeleSoft, TeleGen2 Ada Development System for VAX to E68K, Version 3.23, VAXserver 3602 Host and Motorola MVME117 (MC68010) Target

DTIC Science & Technology

1989-04-09

01hc ’i.’ f’Pf a- ebc 2i1o.-fer-er~hfom Repo.) tUEFCTE $UP1 * ta ~ (Con’rj 01’?Cre V Pot s’o fneccksa’) ortoiorM’f, by blDc n fumYber) Ada Prcr-7n...CLA53SIF1CA1,O0s or IMIS PA ,j (AhnDetsinfree1 AVF Control Number: AVF-VSP-267.0539 69-01-25-TEL Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number...pragma images controls the creation and allocation of the image table for a specified enumeration type. The default is Deferred, which saves space in the

Advanced technology for America's future in space

NASA Technical Reports Server (NTRS)

1990-01-01

In response to Recommendation 8 of the Augustine Committee Report, NASA's Office of Aeronautics, Exploration and Technology (OAET) developed a proposed 'Integrated Technology Plan for the Civil Space Program' that entails substantial changes in the processes, structure and the content of NASA's space research and technology program. The Space Systems and Technology Advisory Committee (SSTAC, a subcommittee of the NASA Advisory Committee) and several other senior, expert, informed advisory groups conducted a review of NASA's proposed Integrated Technology Plan (ITP). This review was in response to the specific request in Recommendation 8 that 'NASA utilize an expert, outside review process, managed from headquarters, to assist in the allocation of technology funds'. This document, the final report from that review, addresses: (1) summary recommendations; (2) mission needs; (3) the integrated technology plan; (4) summary reports of the technical panels; and (5) conclusions and observations.

Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review.

PubMed

Weir, Christopher J; Butcher, Isabella; Assi, Valentina; Lewis, Stephanie C; Murray, Gordon D; Langhorne, Peter; Brady, Marian C

2018-03-07

Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary information on the mean or variability often goes unreported. While full reporting of original trial data is the ideal, we sought to identify methods for handling unreported mean or variability summary statistics in meta-analysis. We undertook two systematic literature reviews to identify methodological approaches used to deal with missing mean or variability summary statistics. Five electronic databases were searched, in addition to the Cochrane Colloquium abstract books and the Cochrane Statistics Methods Group mailing list archive. We also conducted cited reference searching and emailed topic experts to identify recent methodological developments. Details recorded included the description of the method, the information required to implement the method, any underlying assumptions and whether the method could be readily applied in standard statistical software. We provided a summary description of the methods identified, illustrating selected methods in example meta-analysis scenarios. For missing standard deviations (SDs), following screening of 503 articles, fifteen methods were identified in addition to those reported in a previous review. These included Bayesian hierarchical modelling at the meta-analysis level; summary statistic level imputation based on observed SD values from other trials in the meta-analysis; a practical approximation based on the range; and algebraic estimation of the SD based on other summary statistics. Following screening of 1124 articles for methods estimating the mean, one approximate Bayesian computation approach and three papers based on alternative summary statistics were identified. Illustrative meta-analyses showed that when replacing a missing SD the approximation using the range minimised loss of precision and generally performed better than omitting trials. When estimating missing means, a formula using the median, lower quartile and upper quartile performed best in preserving the precision of the meta-analysis findings, although in some scenarios, omitting trials gave superior results. Methods based on summary statistics (minimum, maximum, lower quartile, upper quartile, median) reported in the literature facilitate more comprehensive inclusion of randomised controlled trials with missing mean or variability summary statistics within meta-analyses.

Adaptation to environmental stress in Daphnia magna simultaneously exposed to a xenobiotic.

PubMed

Coors, Anja; Hammers-Wirtz, Monika; Ratte, Hans Toni

2004-07-01

In standardized ecotoxicological testing chemicals are investigated under optimal conditions for the test organisms despite the fact that environmental factors such as predation pressure and food availability are important parameters regulating natural populations. Food limitation and predator presence can induce shifts in life-history traits in various Daphnia species, especially trade-offs in reproductive biomass allocation. These adaptive responses are thought to ensure survival of the population in a highly variable environment. A xenobiotic dispersant (used in textile dyeing processes) also shifted the biomass allocation of Daphnia magna. To assess whether the dispersant could hinder D. magna adaptation to varying environmental conditions, we conducted experiments with food level and presence of Chaoborus larvae as environmental factors and simultaneous exposure to the dispersant. At low food level and in presence of the predator, D. magna produced fewer but larger sized neonates, regardless of dispersant exposure. The dispersant shifted biomass allocation towards more but smaller sized offspring in all experiments. However, the adaptive response to the environmental factors and the dispersant effect cancelled each other out in that they induced independently from each other opposite shifts in biomass allocation. In summary, the dispersant exposure resulted not in an inhibition of the adaptive response but in a reduction of the value of the response. Our study with this model substance demonstrates that xenobiotics can affect the adaptation of organisms to environmental stress which can result in effects likely to be overlooked in standardized testing.

Development of a minimization instrument for allocation of a hospital-level performance improvement intervention to reduce waiting times in Ontario emergency departments.

PubMed

Leaver, Chad Andrew; Guttmann, Astrid; Zwarenstein, Merrick; Rowe, Brian H; Anderson, Geoff; Stukel, Therese; Golden, Brian; Bell, Robert; Morra, Dante; Abrams, Howard; Schull, Michael J

2009-06-08

Rigorous evaluation of an intervention requires that its allocation be unbiased with respect to confounders; this is especially difficult in complex, system-wide healthcare interventions. We developed a short survey instrument to identify factors for a minimization algorithm for the allocation of a hospital-level intervention to reduce emergency department (ED) waiting times in Ontario, Canada. Potential confounders influencing the intervention's success were identified by literature review, and grouped by healthcare setting specific change stages. An international multi-disciplinary (clinical, administrative, decision maker, management) panel evaluated these factors in a two-stage modified-delphi and nominal group process based on four domains: change readiness, evidence base, face validity, and clarity of definition. An original set of 33 factors were identified from the literature. The panel reduced the list to 12 in the first round survey. In the second survey, experts scored each factor according to the four domains; summary scores and consensus discussion resulted in the final selection and measurement of four hospital-level factors to be used in the minimization algorithm: improved patient flow as a hospital's leadership priority; physicians' receptiveness to organizational change; efficiency of bed management; and physician incentives supporting the change goal. We developed a simple tool designed to gather data from senior hospital administrators on factors likely to affect the success of a hospital patient flow improvement intervention. A minimization algorithm will ensure balanced allocation of the intervention with respect to these factors in study hospitals.

Comparing student understanding of quantum physics when embedding multimodal representations into two different writing formats: Presentation format versus summary report format

NASA Astrophysics Data System (ADS)

Gunel, Murat; Hand, Brian; Gunduz, Sevket

2006-11-01

Physics as a subject for school students requires an understanding and ability to move between different modes of representation for the concepts under review. However, the inability of students to have a multimodal understanding of the concepts is seen as restricting their understandings of the concepts. The aim of this study was to explore the effectiveness of using writing-to-learn strategies that required students to embed multimodal representations of the concepts. In particular, the study compared a presentation format with a summary report format for students learning quantum theory. A pre-post test design was used to compare performances of these two groups across two units. For unit 1, students' scores from groups that completed either a presentation format (PowerPoint presentation) or a summary report format (chapter summary) were compared. No limits were placed on the amount of text or the number of representations used. For unit 2, products of both groups were constructed for an audience of year 10 students. The presentation format group (PowerPoint) was limited to 15 slides, with a maximum of 10 words displayed per slide; a script was written to accompany the presentation. Slides could include graphical and mathematical formulae; however, the text could not. The summary report format group that wrote out its explanations was limited to four pages and was required to incorporate multimodal representations. Results indicated that for both units students using the presentation format group scored significantly better on tests than the summary report format group. The effect size difference between the groups increased for the second unit, indicating that more practice was leading to better student understanding of the physics concepts.

An Ecological Momentary Assessment of Primiparous Women’s Breastfeeding Behavior and Problems from Birth to Eight Weeks

PubMed Central

Demirci, Jill R.; Bogen, Debra L.

2017-01-01

Background Primiparous women are at-risk for early, unintended breastfeeding reduction and cessation. Breastfeeding patterns that contribute to these outcomes require further exploration. Research Aim/Questions To describe early, “real time” breastfeeding behaviors and perceived problems of primiparous women. Methods First-time mothers intending to exclusively breastfeed downloaded a commercial infant feeding app during their postpartum hospitalization. Women logged feedings and their breastfeeding experiences, as they occurred, through eight weeks postpartum. Additional feeding and background data were collected via EMR and questionnaires administered at enrollment, two, and eight weeks postpartum. Summary statistics were compiled to examine weekly breastfeeding behaviors and problems. Results In this sample of 61 primarily highly-educated, White women committed to breastfeeding, 38% (n=23) used formula during the postpartum hospitalization and 68% (n=34) used formula at least once by two weeks. Nine women stopped breastfeeding during the study. Women using any formula in the hospital and those with less positive baseline attitudes toward breastfeeding were less likely to be exclusively breastfeeding at two and eight weeks, respectively (p<0.05). There was a trend toward declining at-breast feeds and high rates of milk expression during the study. Breastfeeding problems peaked at Week 2, with 81% of women (n=39) endorsing at least one problem at that time. The most prevalent problems included perception of inadequate milk, pain, latching, and inefficient feeds. Conclusions Interventions to address suboptimal breastfeeding in primiparous women should consider the pervasiveness of early milk expression and in-hospital formula supplementation in this population, as well as the trajectory of common problems. PMID:28418803

The mean and variance of phylogenetic diversity under rarefaction

PubMed Central

Matsen, Frederick A.

2013-01-01

Summary Phylogenetic diversity (PD) depends on sampling depth, which complicates the comparison of PD between samples of different depth. One approach to dealing with differing sample depth for a given diversity statistic is to rarefy, which means to take a random subset of a given size of the original sample. Exact analytical formulae for the mean and variance of species richness under rarefaction have existed for some time but no such solution exists for PD.We have derived exact formulae for the mean and variance of PD under rarefaction. We confirm that these formulae are correct by comparing exact solution mean and variance to that calculated by repeated random (Monte Carlo) subsampling of a dataset of stem counts of woody shrubs of Toohey Forest, Queensland, Australia. We also demonstrate the application of the method using two examples: identifying hotspots of mammalian diversity in Australasian ecoregions, and characterising the human vaginal microbiome.There is a very high degree of correspondence between the analytical and random subsampling methods for calculating mean and variance of PD under rarefaction, although the Monte Carlo method requires a large number of random draws to converge on the exact solution for the variance.Rarefaction of mammalian PD of ecoregions in Australasia to a common standard of 25 species reveals very different rank orderings of ecoregions, indicating quite different hotspots of diversity than those obtained for unrarefied PD. The application of these methods to the vaginal microbiome shows that a classical score used to quantify bacterial vaginosis is correlated with the shape of the rarefaction curve.The analytical formulae for the mean and variance of PD under rarefaction are both exact and more efficient than repeated subsampling. Rarefaction of PD allows for many applications where comparisons of samples of different depth is required. PMID:23833701

Highly multiplexed signal readout for a time-of-flight positron emission tomography detector based on silicon photomultipliers.

PubMed

Cates, Joshua W; Bieniosek, Matthew F; Levin, Craig S

2017-01-01

Maintaining excellent timing resolution in the generation of silicon photomultiplier (SiPM)-based time-of-flight positron emission tomography (TOF-PET) systems requires a large number of high-speed, high-bandwidth electronic channels and components. To minimize the cost and complexity of a system's back-end architecture and data acquisition, many analog signals are often multiplexed to fewer channels using techniques that encode timing, energy, and position information. With progress in the development SiPMs having lower dark noise, after pulsing, and cross talk along with higher photodetection efficiency, a coincidence timing resolution (CTR) well below 200 ps FWHM is now easily achievable in single pixel, bench-top setups using 20-mm length, lutetium-based inorganic scintillators. However, multiplexing the output of many SiPMs to a single channel will significantly degrade CTR without appropriate signal processing. We test the performance of a PET detector readout concept that multiplexes 16 SiPMs to two channels. One channel provides timing information with fast comparators, and the second channel encodes both position and energy information in a time-over-threshold-based pulse sequence. This multiplexing readout concept was constructed with discrete components to process signals from a [Formula: see text] array of SensL MicroFC-30035 SiPMs coupled to [Formula: see text] Lu 1.8 Gd 0.2 SiO 5 (LGSO):Ce (0.025 mol. %) scintillators. This readout method yielded a calibrated, global energy resolution of 15.3% FWHM at 511 keV with a CTR of [Formula: see text] FWHM between the 16-pixel multiplexed detector array and a [Formula: see text] LGSO-SiPM reference detector. In summary, results indicate this multiplexing scheme is a scalable readout technique that provides excellent coincidence timing performance.

Comparison of Estimated Energy Requirements in Severely Burned Patients With Measurements by Using Indirect Calorimetry

PubMed Central

Tancheva, D.; Arabadziev, J.; Gergov, G.; Lachev, N.; Todorova, S.; Hristova, A.

2005-01-01

Summary Severe burn injuries give rise to an extreme state of physiological stress. No other trauma results in such an accelerated rate of tissue catabolism, loss of lean body mass, and depletion of energy and protein reserves. A heightened attention to energy needs is essential, and the significance of adequate nutritional support in the complex management of patients with major burns is very important. The purpose of this study is to compare the results obtained by three of the most popular methods of estimating energy requirements in severely burned adult patients with the measurements of resting energy (REE) expenditure by indirect calorimetry (IC). A prospective study was carried out of 20 patients (male/female ratio, 17/3; mean age, 37.83 ± 10.86 yr), without accompanying morbidities, with burn injuries covering a mean body surface area of 34.27 ± 11.55% and a mean abbreviated burn severity index of 7.44 ± 1.58. During the first 30 days after trauma, the energy requirements were estimated using the Curreri, Long, and Toronto formulas. Twice weekly measurements of REE by IC were obtained. It was found that the Curreri and Long formulas overestimated the energy requirements in severely burned patients, as found by other investigators. However, no significant difference was found between the daily energy requirements calculated by the Toronto formula and the measured REE values by IC. It is concluded that the Toronto formula can be used as an alternative method for estimating the energy requirements of patients with major burns in cases where IC is not available or not applicable. PMID:21990973

Combining rigour with relevance: a novel methodology for testing Chinese herbal medicine.

PubMed

Flower, Andrew; Lewith, George; Little, Paul

2011-03-24

There is a need to develop an evidence base for Chinese herbal medicine (CHM) that is both rigorous and reflective of good practice. This paper proposes a novel methodology to test individualised herbal decoctions using a randomised, double blinded, placebo controlled clinical trial. A feasibility study was conducted to explore the role of CHM in the treatment of endometriosis. Herbal formulae were pre-cooked and dispensed as individual doses in sealed plastic sachets. This permitted the development and testing of a plausible placebo decoction. Participants were randomised at a distant pharmacy to receive either an individualised herbal prescription or a placebo. The trial met the predetermined criteria for good practice. Neither the participants nor the practitioner-researcher could reliably identify group allocation. Of the 28 women who completed the trial, in the placebo group (n=15) 3 women (20%) correctly guessed they were on placebo, 8 (53%) thought they were on herbs and 4 (27%) did not know which group they had been allocated to. In the active group (n=13) 2 (15%) though they were on placebo, 8 (62%) thought they were on herbs and 3 (23%) did not know. Randomisation, double blinding and allocation concealment were successful and the study model appeared to be feasible and effective. It is now possible to subject CHM to rigorous scientific scrutiny without compromising model validity. Improvement in the design of the placebo using food colourings and flavourings instead of dried food will help guarantee the therapeutic inertia of the placebo decoction. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Facesheet Wrinkling in Sandwich Structures

NASA Technical Reports Server (NTRS)

Ley, Robert P.; Lin, Weichuan; Mbanefo, Uy

1999-01-01

The purpose of this paper is to provide a concise summary of the state-of-the-art for the analysis of the facesheet wrinkling mode of failure in sandwich structures. This document is not an exhaustive review of the published research related to facesheet wrinkling. Instead, a smaller number of key papers are reviewed in order to provide designers and analysts with a working understanding of the state-of-the-art. Designers and analysts should use this survey to guide their judgement when deciding which one of a wide variety of available facesheet wrinkling design formulas is applicable to a specific design problem.

Performance of toxicity probability interval based designs in contrast to the continual reassessment method

PubMed Central

Horton, Bethany Jablonski; Wages, Nolan A.; Conaway, Mark R.

2016-01-01

Toxicity probability interval designs have received increasing attention as a dose-finding method in recent years. In this study, we compared the two-stage, likelihood-based continual reassessment method (CRM), modified toxicity probability interval (mTPI), and the Bayesian optimal interval design (BOIN) in order to evaluate each method's performance in dose selection for Phase I trials. We use several summary measures to compare the performance of these methods, including percentage of correct selection (PCS) of the true maximum tolerable dose (MTD), allocation of patients to doses at and around the true MTD, and an accuracy index. This index is an efficiency measure that describes the entire distribution of MTD selection and patient allocation by taking into account the distance between the true probability of toxicity at each dose level and the target toxicity rate. The simulation study considered a broad range of toxicity curves and various sample sizes. When considering PCS, we found that CRM outperformed the two competing methods in most scenarios, followed by BOIN, then mTPI. We observed a similar trend when considering the accuracy index for dose allocation, where CRM most often outperformed both the mTPI and BOIN. These trends were more pronounced with increasing number of dose levels. PMID:27435150

Proceduralism and its role in economic evaluation and priority setting in health.

PubMed

Jan, Stephen

2014-05-01

This paper provides a critical overview of Gavin Mooney's proceduralist approach to economic evaluation and priority setting in health. Proceduralism is the notion that the social value attached to alternative courses of action should be determined not only by outcomes, but also processes. Mooney's brand of proceduralism was unique and couched within a broader critique of 'neo-liberal' economics. It operated on a number of levels. At the micro level of the individual program, he pioneered the notion that 'process utility' could be valued and measured within economic evaluation. At a macro level, he developed a framework in which the social objective of equity was defined by procedural justice in which communitarian values were used as the basis for judging how resources should be allocated across the health system. Finally, he applied the notion of procedural justice to further our understanding of the political economy of resource allocation; highlighting how fairness in decision making processes can overcome the sometimes intractable zero-sum resource allocation problem. In summary, his contributions to this field have set the stage for innovative programs of research to help in developing health policies and programs that are both in alignment with community values and implementable. Copyright © 2014 Elsevier Ltd. All rights reserved.

Variations of DOM quality in inflows of a drinking water reservoir: linking of van Krevelen diagrams with EEMF spectra by rank correlation.

PubMed

Herzsprung, Peter; von Tümpling, Wolf; Hertkorn, Norbert; Harir, Mourad; Büttner, Olaf; Bravidor, Jenny; Friese, Kurt; Schmitt-Kopplin, Philippe

2012-05-15

Elevated concentrations of dissolved organic matter (DOM) such as humic substances in raw water pose significant challenges during the processing of the commercial drinking water supplies. This is a relevant issue in Saxony, Central East Germany, and many other regions worldwide, where drinking water is produced from raw waters with noticeable presence of chromophoric DOM (CDOM), which is assumed to originate from forested watersheds in spring regions of the catchment area. For improved comprehension of DOM molecular composition, the seasonal and spatial variations of humic-like fluorescence and elemental formulas in the catchment area of the Muldenberg reservoir were recorded by excitation emission matrix fluorescence (EEMF) and ultrahigh-resolution mass spectrometry (FT-ICR-MS). The Spearman rank correlation was applied to link the EEMF intensities with exact molecular formulas and their corresponding relative mass peak abundances. Thereby, humic-like fluorescence could be allocated to the pool of oxygen-rich and relatively unsaturated components with stoichiometries similar to those of tannic acids, which are suspected to have a comparatively high disinfection byproduct formation potential associated with the chlorination of raw water. Analogous relationships were established for UV absorption at 254 nm (UV(254)) and dissolved organic carbon (DOC) and compared to the EEMF correlation.

Nutritional support of malnourished lactose intolerant African patients.

PubMed

O'Keefe, S J; Adam, J K; Cakata, E; Epstein, S

1984-09-01

The effectiveness of two commonly available liquid diets was assessed in 40 severely malnourished black African patients. All patients were shown to have normal xylose absorption. The diets were given according to the manufacturer's recommendations. One diet was lactose containing (LC diet) (150 g/d) and high protein (112 g/d), the other normal protein and lactose free (LF diet) (protein 67 g/d), total energy content being similar. Patients were randomly divided into two equal groups and allocated (blind) to one of the diets. Tolerance and nitrogen balance were assessed over two three day periods on half and then full strength formulations. Severe intolerant symptoms were observed in 50% of patients on half strength and 94% of patients on full strength lactose containing diet with evidence of malabsorption of fluid, nitrogen, and fat. Despite high stool nitrogen losses (3.75 +/- 1.04 g/d), however, positive nitrogen balance was achieved in most patients receiving the full strength LC formulation. On the other hand, the full strength LF diet was generally well tolerated and was associated with significantly lower faecal losses and positive nitrogen balance. The results indicate that high density lactose containing liquid formulae are poorly tolerated by severely malnourished black African patients, while lactose free formulae containing approximately 10 g nitrogen/d are well tolerated and result in positive nitrogen balance.

WinClastour—a Visual Basic program for tourmaline formula calculation and classification

NASA Astrophysics Data System (ADS)

Yavuz, Fuat; Yavuz, Vural; Sasmaz, Ahmet

2006-10-01

WinClastour is a Microsoft ® Visual Basic 6.0 program that enables the user to enter and calculate structural formulae of tourmaline analyses obtained both by the electron-microprobe or wet-chemical analyses. It is developed to predict cation site-allocations at the different structural positions, as well as to estimate mole percent of the end-members of the calcic-, alkali-, and X-site vacant group tourmalines. Using the different normalization schemes, such as 24.5 oxygens, 31 anions, 15 cations ( T+ Z+ Y), and 6 silicons, the present program classifies tourmaline data based on the classification scheme proposed by Hawthorne and Henry [1999. Classification of the minerals of the tourmaline group. European Journal of Mineralogy 11, 201-215]. The present program also enables the user Al-Mg disorder between Y and Z sites. WinClastour stores all the calculated results in a comma-delimited ASCII file format. Hence, output of the program can be displayed and processed by any other software for general data manipulation and graphing purposes. The compiled program code together with a test data file and related graphic files, which are designed to produce a high-quality printout from the Grapher program of Golden Software, is approximately 3 Mb as a self-extracting setup file.

Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.

PubMed

Whittamore, Jonathan M; Hatch, Marguerite

2017-09-01

The ileum is considered the primary site of inorganic sulfate ([Formula: see text]) absorption. In the present study, we explored the contributions of the apical chloride/bicarbonate (Cl - /[Formula: see text]) exchangers downregulated in adenoma (DRA; Slc26a3), and putative anion transporter 1 (PAT1; Slc26a6), to the underlying transport mechanism. Transepithelial 35 [Formula: see text] and 36 Cl - fluxes were determined across isolated, short-circuited segments of the distal ileum from wild-type (WT), DRA-knockout (KO), and PAT1-KO mice, together with measurements of urine and plasma sulfate. The WT distal ileum supported net sulfate absorption [197.37 ± 13.61 (SE) nmol·cm -2 ·h -1 ], but neither DRA nor PAT1 directly contributed to the unidirectional mucosal-to-serosal flux ([Formula: see text]), which was sensitive to serosal (but not mucosal) DIDS, dependent on Cl - , and regulated by cAMP. However, the absence of DRA significantly enhanced net sulfate absorption by one-third via a simultaneous rise in [Formula: see text] and a 30% reduction to the secretory serosal-to-mucosal flux ([Formula: see text]). We propose that DRA, together with PAT1, contributes to [Formula: see text] by mediating sulfate efflux across the apical membrane. Associated with increased ileal sulfate absorption in vitro, plasma sulfate was 61% greater, and urinary sulfate excretion ( U SO4 ) 2.2-fold higher, in DRA-KO mice compared with WT controls, whereas U SO4 was increased 1.8-fold in PAT1-KO mice. These alterations to sulfate homeostasis could not be accounted for by any changes to renal sulfate handling suggesting that the source of this additional sulfate was intestinal. In summary, we characterized transepithelial sulfate fluxes across the mouse distal ileum demonstrating that DRA (and to a lesser extent, PAT1) secretes sulfate with significant implications for intestinal sulfate absorption and overall homeostasis. NEW & NOTEWORTHY Sulfate is an essential anion that is actively absorbed from the small intestine involving members of the Slc26 gene family. Here, we show that the main intestinal chloride transporter Slc26a3, known as downregulated in adenoma (DRA), also handles sulfate and contributes to its secretion into the lumen. In the absence of functional DRA (as in the disease congenital chloride diarrhea), net intestinal sulfate absorption was significantly enhanced resulting in substantial alterations to overall sulfate homeostasis. Copyright © 2017 the American Physiological Society.

Effectiveness of multifaceted hand hygiene interventions in long-term care facilities in Hong Kong: a cluster-randomized controlled trial.

PubMed

Ho, Mei-lin; Seto, Wing-hong; Wong, Lai-chin; Wong, Tin-yau

2012-08-01

To determine the effectiveness of World Health Organization (WHO) multimodal strategy in promoting hand hygiene (HH) among healthcare workers (HCWs) in long-term care facilities (LTCFs). Cluster-randomized controlled trial. Eighteen homes for the elderly in Hong Kong were randomly allocated to 2 intervention arms and a control arm. Direct observation of HH practice was conducted by trained nurses. Either handrubbing with alcohol-based handrub (ABHR) or handwashing with liquid soap and water was counted as a compliant action. Disease notification data during 2007-2010 were used to calculate incidence rate ratio (IRR). Managers and HCWs of the participating homes. The WHO multimodal strategy was employed. All intervention homes were supplied with ABHR (WHO formulation I), ABHR racks, pull reels, HH posters and reminders, a health talk, video clips, training materials, and performance feedback. The only difference was that intervention arms 1 and 2 were provided with slightly powdered and powderless gloves, respectively. A total of 11,669 HH opportunities were observed. HH compliance increased from 27.0% to 60.6% and from 22.2% to 48.6% in intervention arms 1 and 2, respectively. Both intervention arms showed increased HH compliance after intervention compared to controls, at 21.6% compliance (both [Formula: see text]). Provision of slightly powdered versus powderless gloves did not have any significant impact on ABHR usage. Respiratory outbreaks (IRR, 0.12; 95% confidence interval [CI], 0.01-0.93; [Formula: see text]) and methicillin-resistant Staphylococcus aureus infections requiring hospital admission (IRR, 0.61; 95% CI, 0.38-0.97; [Formula: see text]) were reduced after intervention. A promotion program applying the WHO multimodal strategy was effective in improving HH among HCWs in LTCFs.

Constructing Space-Time Views from Fixed Size Statistical Data: Getting the Best of both Worlds

NASA Technical Reports Server (NTRS)

Schmidt, Melisa; Yan, Jerry C.

1997-01-01

Many performance monitoring tools are currently available to the super-computing community. The performance data gathered and analyzed by these tools fall under two categories: statistics and event traces. Statistical data is much more compact but lacks the probative power event traces offer. Event traces, on the other hand, can easily fill up the entire file system during execution such that the instrumented execution may have to be terminated half way through. In this paper, we propose an innovative methodology for performance data gathering and representation that offers a middle ground. The user can trade-off tracing overhead, trace data size vs. data quality incrementally. In other words, the user will be able to limit the amount of trace collected and, at the same time, carry out some of the analysis event traces offer using space-time views for the entire execution. Two basic ideas arc employed: the use of averages to replace recording data for each instance and formulae to represent sequences associated with communication and control flow. With the help of a few simple examples, we illustrate the use of these techniques in performance tuning and compare the quality of the traces we collected vs. event traces. We found that the trace files thus obtained are, in deed, small, bounded and predictable before program execution and that the quality of the space time views generated from these statistical data are excellent. Furthermore, experimental results showed that the formulae proposed were able to capture 100% of all the sequences associated with 11 of the 15 applications tested. The performance of the formulae can be incrementally improved by allocating more memory at run-time to learn longer sequences.

Constructing Space-Time Views from Fixed Size Statistical Data: Getting the Best of Both Worlds

NASA Technical Reports Server (NTRS)

Schmidt, Melisa; Yan, Jerry C.; Bailey, David (Technical Monitor)

1996-01-01

Many performance monitoring tools are currently available to the super-computing community. The performance data gathered and analyzed by these tools fall under two categories: statistics and event traces. Statistical data is much more compact but lacks the probative power event traces offer. Event traces, on the other hand, can easily fill up the entire file system during execution such that the instrumented execution may have to be terminated half way through. In this paper, we propose an innovative methodology for performance data gathering and representation that offers a middle ground. The user can trade-off tracing overhead, trace data size vs. data quality incrementally. In other words, the user will be able to limit the amount of trace collected and, at the same time, carry out some of the analysis event traces offer using spacetime views for the entire execution. Two basic ideas are employed: the use of averages to replace recording data for each instance and "formulae" to represent sequences associated with communication and control flow. With the help of a few simple examples, we illustrate the use of these techniques in performance tuning and compare the quality of the traces we collected vs. event traces. We found that the trace files thus obtained are, in deed, small, bounded and predictable before program execution and that the quality of the space time views generated from these statistical data are excellent. Furthermore, experimental results showed that the formulae proposed were able to capture 100% of all the sequences associated with 11 of the 15 applications tested. The performance of the formulae can be incrementally improved by allocating more memory at run-time to learn longer sequences.

Neonatal high protein intake enhances neonatal growth without significant adverse renal effects in spontaneous IUGR piglets.

PubMed

Boubred, Farid; Jamin, Agnes; Buffat, Christophe; Daniel, Laurent; Borel, Patrick; Boudry, Gaëlle; Le Huëron-Luron, Isabelle; Simeoni, Umberto

2017-05-01

In humans, early high protein (HP) intake has been recommended to prevent postnatal growth restriction and complications of intrauterine growth restriction (IUGR). However, the impact of such a strategy on the kidneys remains unknown, while significant renal hypertrophy, proteinuria, and glomerular sclerosis have been demonstrated in few experimental studies. The objective of this study was to evaluate the effects of a neonatal HP formula on renal structure in IUGR piglets. Spontaneous IUGR piglets were randomly allocated to normal protein (NP, n  = 10) formula or to HP formula (+50% protein content, n  = 10) up to day 28 after birth. Body weight, body composition, renal functions, and structure were assessed at the end of the neonatal period. While birth weights were similar, 28-day-old HP piglets were 18% heavier than NP piglets ( P  <   0.01). Carcass protein content was 22% higher in HP than in NP offspring ( P  <   0.01). Despite a HP intake, kidney weight and glomerular fibrosis were unaltered in HP piglets. Only a 20% increase in glomerular volume was noted in HP piglets ( P  < 0.05) and restricted to the inner cortical area nephrons ( P  =   0.03). Plasma urea/creatinine ratio and proteinuria were unchanged in HP piglets. In conclusion, neonatal HP feeding in IUGR piglets significantly enhanced neonatal growth and tissue protein deposition but mildly affected glomerular volume. It can be speculated that a sustained tissue protein anabolism in response to HP intake have limited single nephron glomerular hyperfiltration. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

Know Your Epidemic, Strengthen Your Response: Developing a New HIV Surveillance Architecture to Guide HIV Resource Allocation and Target Decisions

PubMed Central

Sanchez, Travis; Baral, Stefan; Mee, Paul; Sabin, Keith; Garcia-Calleja, Jesus M; Hargreaves, James

2018-01-01

To guide HIV prevention and treatment activities up to 2020, we need to generate and make better use of high quality HIV surveillance data. To highlight our surveillance needs, a special collection of papers in JMIR Public Health and Surveillance has been released under the title “Improving Global and National Responses to the HIV Epidemic Through High Quality HIV Surveillance Data.” We provide a summary of these papers and highlight methods for developing a new HIV surveillance architecture. PMID:29444766

FORM version 4.0

NASA Astrophysics Data System (ADS)

Kuipers, J.; Ueda, T.; Vermaseren, J. A. M.; Vollinga, J.

2013-05-01

We present version 4.0 of the symbolic manipulation system FORM. The most important new features are manipulation of rational polynomials and the factorization of expressions. Many other new functions and commands are also added; some of them are very general, while others are designed for building specific high level packages, such as one for Gröbner bases. New is also the checkpoint facility, that allows for periodic backups during long calculations. Finally, FORM 4.0 has become available as open source under the GNU General Public License version 3. Program summaryProgram title: FORM. Catalogue identifier: AEOT_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEOT_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 151599 No. of bytes in distributed program, including test data, etc.: 1 078 748 Distribution format: tar.gz Programming language: The FORM language. FORM itself is programmed in a mixture of C and C++. Computer: All. Operating system: UNIX, LINUX, Mac OS, Windows. Classification: 5. Nature of problem: FORM defines a symbolic manipulation language in which the emphasis lies on fast processing of very large formulas. It has been used successfully for many calculations in Quantum Field Theory and mathematics. In speed and size of formulas that can be handled it outperforms other systems typically by an order of magnitude. Special in this version: The version 4.0 contains many new features. Most important are factorization and rational arithmetic. The program has also become open source under the GPL. The code in CPC is for reference. You are encouraged to upload the most recent sources from www.nikhef.nl/form/formcvs.php because of frequent bug fixes. Solution method: See "Nature of Problem", above. Additional comments: NOTE: The code in CPC is for reference. You are encouraged to upload the most recent sources from www.nikhef.nl/form/formcvs.php because of frequent bug fixes.

What's new in atopic eczema? An analysis of systematic reviews published in 2010-11.

PubMed

Torley, D; Futamura, M; Williams, H C; Thomas, K S

2013-07-01

This review provides a summary of key findings from 24 systematic reviews of atopic eczema (AE) published or indexed between 1 August 2010 and 31 December 2011, updating published summaries from previous years. Epidemiological evidence points to the protective effects of early daycare, endotoxin exposure, consumption of unpasteurized milk, and early exposure to dogs, but antibiotic use in early life may increase the risk for AE. With regard to prevention of AE, there is currently no strong evidence of benefit for exclusive breastfeeding, hydrolysed protein formulas, soy formulas, maternal antigen avoidance, omega-3 or omega-6 fatty-acid supplementation, or use of prebiotics or probiotics. With respect to AE treatments, the most compelling new systematic review evidence was for proactive treatment with topical anti-inflammatory agents (topical corticosteroids and topical calcineurin inhibitors) for the prevention of AE flares in patients with moderate to severe AE. A meta-analysis of 4 trials confirmed the superiority of tacrolimus 0.1% over pimecrolimus for the treatment of AE, and a review of 17 trials found that tacrolimus (0.1% or 0.03%) was broadly similar in efficacy to mild/moderate topical corticosteroids. Evidence for the role of education in the management of AE was less conclusive, with evidence from randomized controlled trials showing mixed results. Further work is needed in this area to conduct high-quality trials of educational interventions that are clearly described and reproducible. There is no clear evidence for the efficacy of homeopathy, botanical extracts or Chinese herbal medicine in the treatment of AE, as large well-designed trials are lacking in these areas. © 2013 British Association of Dermatologists.

Design and analysis of three-arm trials with negative binomially distributed endpoints.

PubMed

Mütze, Tobias; Munk, Axel; Friede, Tim

2016-02-20

A three-arm clinical trial design with an experimental treatment, an active control, and a placebo control, commonly referred to as the gold standard design, enables testing of non-inferiority or superiority of the experimental treatment compared with the active control. In this paper, we propose methods for designing and analyzing three-arm trials with negative binomially distributed endpoints. In particular, we develop a Wald-type test with a restricted maximum-likelihood variance estimator for testing non-inferiority or superiority. For this test, sample size and power formulas as well as optimal sample size allocations will be derived. The performance of the proposed test will be assessed in an extensive simulation study with regard to type I error rate, power, sample size, and sample size allocation. For the purpose of comparison, Wald-type statistics with a sample variance estimator and an unrestricted maximum-likelihood estimator are included in the simulation study. We found that the proposed Wald-type test with a restricted variance estimator performed well across the considered scenarios and is therefore recommended for application in clinical trials. The methods proposed are motivated and illustrated by a recent clinical trial in multiple sclerosis. The R package ThreeArmedTrials, which implements the methods discussed in this paper, is available on CRAN. Copyright © 2015 John Wiley & Sons, Ltd.

Evaluation of seatback vibration based on ISO 2631-1 (1997) standard method: The influence of vehicle seat structural resonance.

PubMed

Ittianuwat, R; Fard, M; Kato, K

2017-01-01

Although much research has been done in developing the current ISO 2631-1 (1997) standard method for assessment seat vibration comfort, little consideration has been given to the influence of vehicle seat structural dynamics on comfort assessment. Previous research has shown that there are inconsistencies between standard methods and subjective evaluation of comfort at around vehicle seat twisting resonant frequencies. This study reports the frequency-weighted r.m.s. accelerations in [Formula: see text], [Formula: see text] and [Formula: see text] axes and the total vibration (point vibration total value) at five locations on seatback surface at around vehicle seat twisting resonant frequencies. The results show that the vibration measured at the centre of seatback surface, suggested by current ISO 2631-1 (1997), at around twisting resonant frequencies was the least for all tested vehicle seats. The greatest point vibration total value on the seatback surface varies among vehicle seats. The variations in vibration measured at different locations on seatback surface at around twisting resonant frequencies were sufficiently great that might affect the comfort assessment of vehicle seat.Practitioner Summary: The influence of vehicle seat structural dynamics has not been considered in current ISO 2631-1 (1997). The results of this study show that the vibration measures on seatback surface at around vehicle seat twisting resonant frequency depends on vehicle seats and dominate at the top or the bottom of seatback but not at the centre.

Decreasing Enterobacter sakazakii (Cronobacter spp.) food contamination level with bacteriophages: prospects and problems

PubMed Central

Zuber, Sophie; Boissin‐Delaporte, Catherine; Michot, Lise; Iversen, Carol; Diep, Benjamin; Brüssow, Harald; Breeuwer, Pieter

2008-01-01

Summary Enterobacter sakazakii (Cronobacter spp.) is an opportunistic pathogen, which can cause rare, but life‐threatening infections in neonates and infants through feeding of a contaminated milk formula. We isolated 67 phages from environmental samples and tested their lytic host range on a representative collection of 40 E. sakazakii strains. A cocktail of five phages prevented the outgrowth of 35 out of 40 test strains in artificially contaminated infant formula. Two E. sakazakii phages represented prolate head Myoviridae. Molecular tests identified them as close relatives of Escherichia coli phage T4. The remaining three phages represented isometric head Myoviridae with large genome size of 140 and 200 kb, respectively, which belonged to two different DNA hybridization groups. A high dose of 108 pfu ml−1 of phage could effectively sterilize a broth contaminated with both high and low pathogen counts (106 and 102 cfu ml−1). In contrast, broth inoculated with 104 phage and 102 bacteria per ml first showed normal bacterial growth until reaching a cell titre of 105 cfu ml−1. Only when crossing this threshold, phage replication started, but it could not reduce the contamination level below 100 cfu ml−1. Phages could be produced with titres of 1010 pfu ml−1 in broth culture, but they were not stable upon freeze‐drying. Addition of trehalose or milk formula stabilized the phage preparation, which then showed excellent storage stability even at elevated temperature. PMID:21261874

Kinky thresholds revisited: opportunity costs differ in the NE and SW quadrants.

PubMed

Eckermann, Simon

2015-02-01

Historically, a kinked threshold line on the cost-effectiveness plane at the origin was suggested due to differences in willingness to pay (WTP) for health gain with trade-offs in the north-east (NE) quadrant versus willingness to accept (WTA) cost reductions for health loss with trade-offs in the south-west (SW) quadrant. Empirically, WTA is greater than WTP for equivalent units of health, a finding supported by loss aversion under prospect theory. More recently, appropriate threshold values for health effects have been shown to require an endogenous consideration of the opportunity cost of alternative actions in budget-constrained health systems, but also allocative and displacement inefficiency observed in health system practice. Allocative and displacement inefficiency arise in health systems where the least cost-effective program in contraction has a higher incremental cost-effectiveness ratio (ICER = m) than the most cost-effective program in expansion (ICER = n) and displaced services (ICER = d), respectively. The health shadow price derived by Pekarsky, [Formula: see text] reflects the opportunity cost of best alternative adoption and financing actions in reimbursing new technology with expected incremental costs and net effect allowing for allocative (n < m), and displacement, inefficiency (d < m). This provides an appropriate threshold value for the NE quadrant. In this paper, I show that for trade-offs in the SW quadrant, where new strategies have lower expected net cost while lower expected net effect than current practice, the opportunity cost is contraction of the least cost-effective program, with threshold ICER m. That is, in the SW quadrant, the cost reduction per unit of decreased effect should be compared with the appropriate opportunity cost, best alternative generation of funding. Consequently, appropriate consideration of opportunity cost produces a kink in the threshold at the origin, with the health shadow price in the NE quadrant and ICER of the least cost-effective program in contraction (m) in the SW quadrant having the same general shape as that previously suggested by WTP versus WTA. The extent of this kink depends on the degree of allocative and displacement inefficiency, with no kink in the threshold line strictly only appropriate with complete allocative and displacement efficiency, that is n = d = m.

Blockage corrections for three-dimensional-flow closed-throat wind tunnels, with consideration of the effect of compressibility

NASA Technical Reports Server (NTRS)

Herriot, John G

1947-01-01

Theoretical blockage corrections are presented for a body of revolution and for a three-dimensional unswept wing in a circular or rectangular wind tunnel. The theory takes account of the effects of the wake and of the compressibility of the fluid, and is based on the assumption that the dimensions of the model are small in comparison with those of the tunnel throat. Formulas are given for correcting a number of the quantities, such as dynamic pressure and Mach number, measured in wind-tunnel tests. The report presents a summary and unification of the existing literature on the subject.

Acute responses to exercise training and relationship with exercise adherence in moderate chronic obstructive pulmonary disease.

PubMed

Rizk, Amanda K; Wardini, Rima; Chan-Thim, Emilie; Bacon, Simon L; Lavoie, Kim L; Pepin, Véronique

2015-11-01

The objectives of our study were to (i) compare, in chronic obstructive pulmonary disease (COPD) patients, acute responses to continuous training at high intensity (CTHI), continuous training at ventilatory threshold (CTVT) and interval training (IT); (ii) examine associations between acute responses and 12-week adherence; and (iii) investigate whether the relationship between acute responses and adherence is mediated/moderated by affect/vigour. Thirty-five COPD patients (forced expiratory volume in 1 second = 60.2 ± 15.8% predicted), underwent baseline assessments, were randomly assigned to CTHI, CTVT or IT, were monitored throughout about before training, and underwent 12 weeks of exercise training during which adherence was tracked. Compared with CTHI, CTVT was associated with lower respiratory exchange ratio, heart rate and respiratory rate (RR), while IT induced higher [Formula: see text], [Formula: see text]maximal voluntary ventilation, RR and lower pulse oxygen saturation. From pre- to post-exercise, positive affect increased (F = 9.74, p < 0.001) and negative affect decreased (F = 6.43, p = 0.005) across groups. CTVT reported greater end-exercise vigour compared to CTHI (p = 0.01) and IT (p = 0.02). IT exhibited lowest post-exercise vigour (p = 0.04 versus CTHI, p = 0.02 versus CTVT) and adherence rate (F = 6.69, p = 0.004). Mean [Formula: see text] (r = -0.466, p = 0.007) and end-exercise vigour (r = 0.420, p = 0.017) were most strongly correlated with adherence. End-exercise vigour moderated the relationship between [Formula: see text] and adherence (β = 2.74, t(32) = 2.32, p = 0.03). In summary, CTHI, CTVT and IT improved affective valence from rest to post-exercise and induced a significant 12-week exercise training effect. However, they elicited different acute physiological responses, which in turn were associated with differences in 12-week adherence to the target training intensity. This association was moderated by acute end-exercise vigour. © The Author(s) 2015.

Early enteral feeding in postsurgical cancer patients. Fish oil structured lipid-based polymeric formula versus a standard polymeric formula.

PubMed Central

Kenler, A S; Swails, W S; Driscoll, D F; DeMichele, S J; Daley, B; Babineau, T J; Peterson, M B; Bistrian, B R

1996-01-01

OBJECTIVES: The authors compared the safety, gastrointestinal tolerance, and clinical efficacy of feeding an enteral diet containing a fish oil/medium-chain triglyceride structured lipid (FOSL-HN) versus an isonitrogenous, isocaloric formula (O-HN) in patients undergoing major abdominal surgery for upper gastrointestinal malignancies. SUMMARY BACKGROUND DATA: Previous studies suggest that feeding with n-3 fatty acids from fish oil can alter eicosanoid and cytokine production, yielding an improved immunocompetence and a reduced inflammatory response to injury. The use of n-3 fatty acids as a structured lipid can improve long-chain fatty acid absorption. METHODS: This prospective, blinded, randomized trial was conducted in 50 adult patients who were jejunally fed either FOSL-HN or O-HN for 7 days. Serum chemistries, hematology, urinalysis, gastrointestinal complications, liver and renal function, plasma and erythrocyte fatty acid analysis, urinary prostaglandins, and outcome parameters were measured at baseline and on day 7. Comparisons were made in 18 and 17 evaluable patients based a priori on the ability to reach a tube feeding rate of 40 mL/hour. RESULTS: Patients receiving FOSL-HN experienced no untoward side effects, significant incorporation of eicosapentaenoic acid into plasma and erythrocyte phospholipids, and a 50% decline in the total number of gastrointestinal complications and infections compared with patients given O-HN. The data strongly suggest improved liver and renal function during the postoperative period in the FOSL-HN group. CONCLUSION: Early enteral feeding with FOSL-HN was safe and well tolerated. Results suggest that the use of such a formula during the postoperative period may reduce the number of infections and gastrointestinal complications per patient, as well as improve renal and liver function through modulation of urinary prostaglandin levels. Additional clinical trials to fully quantify clinical benefits and optimize nutritional support with FOSL-HN should be undertaken. Images Figure 1. Figure 2. Figure 3. PMID:8604913

Ada Compiler Validation Summary Report: Certificate Number: 940630W1. 11372 Rational Software Corporation VADS System V/88 Release 4, VAda-110-8484, Product Number: 2100-01464, Version 6.2 DG AViiON G70592-A (M88110) under UNIX System V Release 4

DTIC Science & Technology

1994-07-21

InforMation Systems Agency, Center for Information Management DECLARATION OF CONFORMANCE The following declaration of conformance was supplied by the...services such as resource allocation, scheduling, inp•t/outp-it control, and data management. Usually, operating systems are predominantly software...Ada programming language. 1-4 CHAPTER 2 IMPLEMMTION DEPENDENC IES 2.1 WITHDRAWN TESTS The f3llowing tests have been withdrawn by the AVO. The

Development of a multi-disciplinary ERTS user program in the state of Ohio. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Baldridge, P. E.; Weber, C.; Schaal, G.; Wilhelm, C.; Wurelic, G. E.; Stephan, J. G.; Ebbert, T. F.; Smail, H. E.; Mckeon, J.; Schmidt, N. (Principal Investigator)

1977-01-01

The author has identified the following significant results. A current uniform land inventory was derived, in part, from LANDSAT data. The State has the ability to convert processed land information from LANDSAT to Ohio Capability Analysis Program (OCAP). The OCAP is a computer information and mapping system comprised of various programs used to digitally store, analyze, and display land capability information. More accurate processing of LANDSAT data could lead to reasonably accurate, useful land allocations models. It was feasible to use LANDSAT data to investigate minerals, pollution, land use, and resource inventory.

Theater-Level Gaming and Analysis Workshop for Force Planning. Volume II. Summary, Discussion of Issues and Requirements for Research. September 27- 29, 1977, Held at Xerox International Center for Training and Management Development, Leesburg, Virginia

DTIC Science & Technology

1981-05-01

be allocated to targets on the battlefield and in the rear area. The speaker describes the VECTOR I/NUCLEAR model, a combination of the UNICORN target...outlined. UNICORN is compatible with VECTOR 1 in level of detail. It is an expected value damage model and uses linear programming to optimize the...and a growing appreciation for the power of simulation in addressing large, complex problems, it was only a few short years before these games had

Modelling the effect of bednet coverage on malaria transmission in South Sudan.

PubMed

Mukhtar, Abdulaziz Y A; Munyakazi, Justin B; Ouifki, Rachid; Clark, Allan E

2018-01-01

A campaign for malaria control, using Long Lasting Insecticide Nets (LLINs) was launched in South Sudan in 2009. The success of such a campaign often depends upon adequate available resources and reliable surveillance data which help officials understand existing infections. An optimal allocation of resources for malaria control at a sub-national scale is therefore paramount to the success of efforts to reduce malaria prevalence. In this paper, we extend an existing SIR mathematical model to capture the effect of LLINs on malaria transmission. Available data on malaria is utilized to determine realistic parameter values of this model using a Bayesian approach via Markov Chain Monte Carlo (MCMC) methods. Then, we explore the parasite prevalence on a continued rollout of LLINs in three different settings in order to create a sub-national projection of malaria. Further, we calculate the model's basic reproductive number and study its sensitivity to LLINs' coverage and its efficacy. From the numerical simulation results, we notice a basic reproduction number, [Formula: see text], confirming a substantial increase of incidence cases if no form of intervention takes place in the community. This work indicates that an effective use of LLINs may reduce [Formula: see text] and hence malaria transmission. We hope that this study will provide a basis for recommending a scaling-up of the entry point of LLINs' distribution that targets households in areas at risk of malaria.

Challenges of rehabilitation case mix measurement in Ontario hospitals.

PubMed

Sutherland, Jason Murray; Walker, Jan

2008-03-01

Case mix classification systems have been adopted in many countries as a method to manage and finance healthcare in acute care settings; the most popular systems are based on diagnosis related groups. The most successful of those case mix systems differentiate patient types by reflecting both the intensity of resources consumed and patient acuity. Case mix systems for use with non-acute hospital activity have not been as wide-spread; other than in the United States, little attention has been directed towards case mix classification for rehabilitation activity. In a province with over 13 million inhabitants with 2496 rehabilitation beds, inpatient rehabilitation is an important component of hospital care in Ontario, Canada, and consists of the spectrum of intensive rehabilitation activities intended to restore function. Although case mix adjusted activity has been the currency in Ontario's Integrated Population Based Allocation hospital funding formula, rehabilitation activity has not been subjected to case mix measurement. A project to examine case mix classification for adult inpatient rehabilitation activity was initiated by the Ontario Ministry of Health and Long-Term Care whose outcome was a case mix system and associated cost weights that would result in rehabilitation activity being incorporated into the hospital funding formula. The process described in this study provides Ontario's provincial government with a case mix classification system for adult inpatient rehabilitation activity although there remain areas for improvement.

Financial and materiel management.

PubMed

Willock, M; Motley, C

1998-01-01

Hospitals have to purchase new technology, update equipment, and replenish supplies continually to meet the needs of patients and the medical and nursing staff in a sound financial way. Thus, inventories must be maintained accurately and adequately with proper controls. Awareness of the cost of capital and operational supplies is essential to meeting budget allocations. With or without centralized buying, the MM department has the expertise to assist every department in purchasing to meet its needs and in setting and resetting inventory levels for its supplies. Explanations and formulas for handling capital equipment and regular supplies and some formats have been presented to facilitate the process. Because OR items are both expensive and numerous and OR storage space the most costly space in the hospital, physicians and nurse managers must understand the financial processes and inventory management and educate their staffs in these matters.

Gas dynamics of a supersonic radial jet. Part II

NASA Astrophysics Data System (ADS)

Kosarev, V. F.; Klinkov, S. V.; Zaikovskii, V. N.

2016-05-01

The paper presents the radial distributions of the pressure measured with a Pitot tube for the case of a radial jet with/without swirling of the input flow in the pre-chamber; the length of the supersonic part of the jet, dependency of the jet thickness as a function of the distance from the nozzle outlet, and approximating analytical formula for the jet thickness that generalizes the experimental data. Experimental data demonstrated that at the deposition distances lower than 4-6 gauges from the nozzle outlet, the solid particle velocity and temperature are almost uniform over the jet cross section. This means that the target surface can be allocated here without loss in coating quality and deposition coefficient. The maximal recommended distance where the deposition is still possible is the length of l s0 ~ 16 gauges.

Interrelation of GDP and pension capital: Mathematical and econometrical analysis

NASA Astrophysics Data System (ADS)

Nepp, A. N.; Dolgodvorov, A. D.

2016-12-01

This article is a mathematicalanalysis of the relationship between GDP and the development of funded pension systems. For this purpose, a mathematical formula was derived from the macro-economic GDP, proportional to the level of income and consumption for the dependence of GDP on the level of pension payments, the value of pension savings and the structure of compulsory contributions to the pension fund allocated to the distribution and accumulative pension system. A derivation of the equation proves the linear relationship of GDP and the share of pension contributions channeled to the funded pension system. Thus, the macroeconomic indicator with the larger negative impact on GDP was proven to be the elimination of the compulsory funded pension system. Based on the econometric analysis, the positive effect of the distributive pension system was proven on macroeconomic parameters.

Implications of the Human Genome Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kitcher, P.

The Human Genome Project (HGP), launched in 1991, aims to map and sequence the human genome by 2006. During the fifteen-year life of the project, it is projected that $3 billion in federal funds will be allocated to it. The ultimate aims of spending this money are to analyze the structure of human DNA, to identify all human genes, to recognize the functions of those genes, and to prepare for the biology and medicine of the twenty-first century. The following summary examines some of the implications of the program, concentrating on its scientific import and on the ethical and socialmore » problems that it raises. Its aim is to expose principles that might be used in applying the information which the HGP will generate. There is no attempt here to translate the principles into detailed proposals for legislation. Arguments and discussion can be found in the full report, but, like this summary, that report does not contain any legislative proposals.« less

[The enigma of the biological interpretation of the linear-quadratic model finally resolved? A summary for non-mathematicians].

PubMed

Bodgi, L; Canet, A; Granzotto, A; Britel, M; Puisieux, A; Bourguignon, M; Foray, N

2016-06-01

The linear-quadratic (LQ) model is the only mathematical formula linking cellular survival and radiation dose that is sufficiently consensual to help radiation oncologists and radiobiologists in describing the radiation-induced events. However, this formula proposed in the 1970s and α and β parameters on which it is based remained without relevant biological meaning. From a collection of cutaneous fibroblasts with different radiosensitivity, built over 12 years by more than 50 French radiation oncologists, we recently pointed out that the ATM protein, major actor of the radiation response, diffuses from the cytoplasm to the nucleus after irradiation. The evidence of this nuclear shuttling of ATM allowed us to provide a biological interpretation of the LQ model in its mathematical features, validated by a hundred of radiosensitive cases. A mechanistic explanation of the radiosensitivity of syndromes caused by the mutation of cytoplasmic proteins and of the hypersensitivity to low-dose phenomenon has been proposed, as well. In this review, we present our resolution of the LQ model in the most didactic way. Copyright © 2016 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

A model for interprovincial air pollution control based on futures prices.

PubMed

Zhao, Laijun; Xue, Jian; Gao, Huaizhu Oliver; Li, Changmin; Huang, Rongbing

2014-05-01

Based on the current status of research on tradable emission rights futures, this paper introduces basic market-related assumptions for China's interprovincial air pollution control problem. The authors construct an interprovincial air pollution control model based on futures prices: the model calculated the spot price of emission rights using a classic futures pricing formula, and determined the identities of buyers and sellers for various provinces according to a partitioning criterion, thereby revealing five trading markets. To ensure interprovincial cooperation, a rational allocation result for the benefits from this model was achieved using the Shapley value method to construct an optimal reduction program and to determine the optimal annual decisions for each province. Finally, the Beijing-Tianjin-Hebei region was used as a case study, as this region has recently experienced serious pollution. It was found that the model reduced the overall cost of reducing SO2 pollution. Moreover, each province can lower its cost for air pollution reduction, resulting in a win-win solution. Adopting the model would therefore enhance regional cooperation and promote the control of China's air pollution. The authors construct an interprovincial air pollution control model based on futures prices. The Shapley value method is used to rationally allocate the cooperation benefit. Interprovincial pollution control reduces the overall reduction cost of SO2. Each province can lower its cost for air pollution reduction by cooperation.

Resolution-Adaptive Hybrid MIMO Architectures for Millimeter Wave Communications

NASA Astrophysics Data System (ADS)

Choi, Jinseok; Evans, Brian L.; Gatherer, Alan

2017-12-01

In this paper, we propose a hybrid analog-digital beamforming architecture with resolution-adaptive ADCs for millimeter wave (mmWave) receivers with large antenna arrays. We adopt array response vectors for the analog combiners and derive ADC bit-allocation (BA) solutions in closed form. The BA solutions reveal that the optimal number of ADC bits is logarithmically proportional to the RF chain's signal-to-noise ratio raised to the 1/3 power. Using the solutions, two proposed BA algorithms minimize the mean square quantization error of received analog signals under a total ADC power constraint. Contributions of this paper include 1) ADC bit-allocation algorithms to improve communication performance of a hybrid MIMO receiver, 2) approximation of the capacity with the BA algorithm as a function of channels, and 3) a worst-case analysis of the ergodic rate of the proposed MIMO receiver that quantifies system tradeoffs and serves as the lower bound. Simulation results demonstrate that the BA algorithms outperform a fixed-ADC approach in both spectral and energy efficiency, and validate the capacity and ergodic rate formula. For a power constraint equivalent to that of fixed 4-bit ADCs, the revised BA algorithm makes the quantization error negligible while achieving 22% better energy efficiency. Having negligible quantization error allows existing state-of-the-art digital beamformers to be readily applied to the proposed system.

Optimality, sample size, and power calculations for the sequential parallel comparison design.

PubMed

Ivanova, Anastasia; Qaqish, Bahjat; Schoenfeld, David A

2011-10-15

The sequential parallel comparison design (SPCD) has been proposed to increase the likelihood of success of clinical trials in therapeutic areas where high-placebo response is a concern. The trial is run in two stages, and subjects are randomized into three groups: (i) placebo in both stages; (ii) placebo in the first stage and drug in the second stage; and (iii) drug in both stages. We consider the case of binary response data (response/no response). In the SPCD, all first-stage and second-stage data from placebo subjects who failed to respond in the first stage of the trial are utilized in the efficacy analysis. We develop 1 and 2 degree of freedom score tests for treatment effect in the SPCD. We give formulae for asymptotic power and for sample size computations and evaluate their accuracy via simulation studies. We compute the optimal allocation ratio between drug and placebo in stage 1 for the SPCD to determine from a theoretical viewpoint whether a single-stage design, a two-stage design with placebo only in the first stage, or a two-stage design is the best design for a given set of response rates. As response rates are not known before the trial, a two-stage approach with allocation to active drug in both stages is a robust design choice. Copyright © 2011 John Wiley & Sons, Ltd.

Assessing the learning curve for the acquisition of laparoscopic skills on a virtual reality simulator.

PubMed

Sherman, V; Feldman, L S; Stanbridge, D; Kazmi, R; Fried, G M

2005-05-01

The aim of this study was to develop summary metrics and assess the construct validity for a virtual reality laparoscopic simulator (LapSim) by comparing the learning curves of three groups with different levels of laparoscopic expertise. Three groups of subjects ('expert', 'junior', and 'naïve') underwent repeated trials on three LapSim tasks. Formulas were developed to calculate scores for efficiency ('time-error') and economy of 'motion' ('motion') using metrics generated by the software after each drill. Data (mean +/- SD) were evaluated by analysis of variance (ANOVA). Significance was set at p < 0.05. All three groups improved significantly from baseline to final for both 'time-error' and 'motion' scores. There were significant differences between groups in time error performances at baseline and final, due to higher scores in the 'expert' group. A significant difference in 'motion' scores was seen only at baseline. We have developed summary metrics for the LapSim that differentiate among levels of laparoscopic experience. This study also provides evidence of construct validity for the LapSim.

Lunar Samples: Apollo Collection Tools, Curation Handling, Surveyor III and Soviet Luna Samples

NASA Technical Reports Server (NTRS)

Allton, J.H.

2009-01-01

The 6 Apollo missions that landed on the lunar surface returned 2196 samples comprised of 382 kg. The 58 samples weighing 21.5 kg collected on Apollo 11 expanded to 741 samples weighing 110.5 kg by the time of Apollo 17. The main goal on Apollo 11 was to obtain some material and return it safely to Earth. As we gained experience, the sampling tools and a more specific sampling strategy evolved. A summary of the sample types returned is shown in Table 1. By year 1989, some statistics on allocation by sample type were compiled [2]. The "scientific interest index" is based on the assumption that the more allocations per gram of sample, the higher the scientific interest. It is basically a reflection of the amount of diversity within a given sample type. Samples were also set aside for biohazard testing. The samples set aside and used for biohazard testing were represen-tative, as opposed to diverse. They tended to be larger and be comprised of less scientifically valuable mate-rial, such as dust and debris in the bottom of sample containers.

Partitioning CO 2 fluxes with isotopologue measurements and modeling to understand mechanisms of forest carbon sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davidson, Eric A.; Saleska, Scott; Savage, Kathleen

1. Project Summary and Objectives This project combines automated in situ observations of the isotopologues of CO 2 with root observations, novel experimental manipulations of belowground processes, and isotope-enabled ecosystem modeling to investigate mechanisms of below- vs. aboveground carbon sequestration at the Harvard Forest Environmental Measurements Site (EMS). The proposed objectives, which have now been largely accomplished, include: A. Partitioning of net ecosystem CO 2 exchange (NEE) into photosynthesis and respiration using long-term continuous observations of the isotopic composition of NEE, and analysis of their dynamics ; B. Investigation of the influence of vegetation phenology on the timing and magnitudemore » of carbon allocated belowground using measurements of root growth and indices of belowground autotrophic vs. heterotrophic respiration (via trenched plots and isotope measurements); C. Testing whether plant allocation of carbon belowground stimulates the microbial decomposition of soil organic matter, using in situ rhizosphere simulation experiments wherein realistic quantities of artificial isotopically-labeled exudates are released into the soil; and D. Synthesis and interpretation of the above data using the Ecosystem Demography Model 2 (ED2).« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Department of Energy Order DOE 5000.4A establishes DOE`s policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 5000.4A, LDRD is ``research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this Order. LDRD includes activities previously defined as ER&D, as well as other discretionary research and development activities not provided for in amore » DOE program.`` Consistent with the Mission Statement and Strategic Plan provided in PNL`s Institutional Plan, the LDRD investments are focused on developing new and innovative approaches in research related to our ``core competencies.`` Currently, PNL`s core competencies have been identified as integrated environmental research; process technology; energy systems research. In this report, the individual summaries of Laboratory-level LDRD projects are organized according to these core competencies. The largest proportion of Laboratory-level LDRD funds is allocated to the core competency of integrated environmental research. A significant proportion of PNL`s LDRD funds are also allocated to projects within the various research centers that are proposed by individual researchers or small research teams. The projects are described in Section 2.0. The projects described in this report represent PNL`s investment in its future and are vital to maintaining the ability to develop creative solutions for the scientific and technical challenges faced by DOE and the nation. In accordance with DOE guidelines, the report provides an overview of PNL`s LDRD program and the management process used for the program and project summaries for each LDRD project.« less

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment.

PubMed

Pasaniuc, Bogdan; Zaitlen, Noah; Shi, Huwenbo; Bhatia, Gaurav; Gusev, Alexander; Pickrell, Joseph; Hirschhorn, Joel; Strachan, David P; Patterson, Nick; Price, Alkes L

2014-10-15

Imputation using external reference panels (e.g. 1000 Genomes) is a widely used approach for increasing power in genome-wide association studies and meta-analysis. Existing hidden Markov models (HMM)-based imputation approaches require individual-level genotypes. Here, we develop a new method for Gaussian imputation from summary association statistics, a type of data that is becoming widely available. In simulations using 1000 Genomes (1000G) data, this method recovers 84% (54%) of the effective sample size for common (>5%) and low-frequency (1-5%) variants [increasing to 87% (60%) when summary linkage disequilibrium information is available from target samples] versus the gold standard of 89% (67%) for HMM-based imputation, which cannot be applied to summary statistics. Our approach accounts for the limited sample size of the reference panel, a crucial step to eliminate false-positive associations, and it is computationally very fast. As an empirical demonstration, we apply our method to seven case-control phenotypes from the Wellcome Trust Case Control Consortium (WTCCC) data and a study of height in the British 1958 birth cohort (1958BC). Gaussian imputation from summary statistics recovers 95% (105%) of the effective sample size (as quantified by the ratio of [Formula: see text] association statistics) compared with HMM-based imputation from individual-level genotypes at the 227 (176) published single nucleotide polymorphisms (SNPs) in the WTCCC (1958BC height) data. In addition, for publicly available summary statistics from large meta-analyses of four lipid traits, we publicly release imputed summary statistics at 1000G SNPs, which could not have been obtained using previously published methods, and demonstrate their accuracy by masking subsets of the data. We show that 1000G imputation using our approach increases the magnitude and statistical evidence of enrichment at genic versus non-genic loci for these traits, as compared with an analysis without 1000G imputation. Thus, imputation of summary statistics will be a valuable tool in future functional enrichment analyses. Publicly available software package available at http://bogdan.bioinformatics.ucla.edu/software/. bpasaniuc@mednet.ucla.edu or aprice@hsph.harvard.edu Supplementary materials are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Comparison of Alternative Evidence Summary and Presentation Formats in Clinical Guideline Development: A Mixed-Method Study

PubMed Central

Opiyo, Newton; Shepperd, Sasha; Musila, Nyokabi; Allen, Elizabeth; Nyamai, Rachel; Fretheim, Atle; English, Mike

2013-01-01

Background Best formats for summarising and presenting evidence for use in clinical guideline development remain less well defined. We aimed to assess the effectiveness of different evidence summary formats to address this gap. Methods Healthcare professionals attending a one-week Kenyan, national guideline development workshop were randomly allocated to receive evidence packaged in three different formats: systematic reviews (SRs) alone, systematic reviews with summary-of-findings tables, and ‘graded-entry’ formats (a ‘front-end’ summary and a contextually framed narrative report plus the SR). The influence of format on the proportion of correct responses to key clinical questions, the primary outcome, was assessed using a written test. The secondary outcome was a composite endpoint, measured on a 5-point scale, of the clarity of presentation and ease of locating the quality of evidence for critical neonatal outcomes. Interviews conducted within two months following completion of trial data collection explored panel members’ views on the evidence summary formats and experiences with appraisal and use of research information. Results 65 (93%) of 70 participants completed questions on the prespecified outcome measures. There were no differences between groups in the odds of correct responses to key clinical questions. ‘Graded-entry’ formats were associated with a higher mean composite score for clarity and accessibility of information about the quality of evidence for critical neonatal outcomes compared to systematic reviews alone (adjusted mean difference 0.52, 95% CI 0.06 to 0.99). There was no difference in the mean composite score between SR with SoF tables and SR alone. Findings from interviews with 16 panelists indicated that short narrative evidence reports were preferred for the improved clarity of information presentation and ease of use. Conclusions Our findings suggest that ‘graded-entry’ evidence summary formats may improve clarity and accessibility of research evidence in clinical guideline development. Trial Registration Controlled-Trials.com ISRCTN05154264 PMID:23372813

Traditional Chinese Medicine for Bradyarrhythmia: Evidence and Potential Mechanisms

PubMed Central

Liu, Shuo; Tian, Guihua; Chen, Jing; Zhang, Xiaoyu; Wu, Aiming; Li, Min; Sun, Yang; Liu, Baoshan; Xing, Yanwei; Shang, Hongcai

2018-01-01

Importance: The incidence of Bradyarrhythmias is high among the population. However, at early stages of the disease, it cannot always get enough attention and is lack of safe and effective therapies, until it is serious enough to resort to pacemaker implantation. Traditional Chinese Medicine (TCM) has a long history of treating Bradyarrhythmia, with a lot of formulas being widely used in clinical practice. While the effectiveness and the underlying mechanisms of these formulas have not yet been clearly identified. Objective: To evaluate the effectiveness of some common TCM formulas in treating patients with Bradyarrhythmia and to summarize the current evidence as to their mechanisms. Data Sources: Relevant studies were identified by searching for papers published from January 2000 to August 2017 in Pubmed; EMBASE; the Cochrane Library (Cochrane Central Register of Controlled Trials); the China National Knowledge Internet; and the China biology medicine, Wanfang, and VIP databases. The following medical subject heading (MeSH) terms were included for Pubmed search and adapted for other databases as needed-“Medicine, Chinese Traditional,” “Bradycardia.” Study Selection: Randomized clinical trials investigating treatment outcomes in Bradyarrhythmia patients with one of the six TCM formulas (Shenxian-shengmai oral liquid, Shensong Yangxin capsule, XinBao pill, Mahuang-Fuzi-Xixin decoction, Zhigancao decoction and Shengmai injection). Data Extraction and Synthesis: Two independent reviewers performed the data extraction and assessed study quality. A meta-analysis was performed to calculate risk ratio (RR) and 95% confidence index (CI) using random-effects and fixed-effects model. Results: A total of 121 clinical trials with 11138 patients were included. Of the six TCM formulas, SXSM (RR:1.33, 95% CI 1.27 to 1.39, P < 0.00001), SSYX (RR:1.52, 95% CI 1.40 to 1.66, P < 0.00001), XB can be more effective than common treatment (RR 1.18, 95% CI 1.11 to 1.26, P < 0.00001), as well as placebo (RR 5.33, 95% CI 2.88-9.87, P < 0.00001), but less effective than TCM dialectical therapy (RR:0.75, 95% CI 0.68 to 0.82, P < 0.00001). Compared to the control group, MFX (RR:1.30, 95%CI 1.23 to 1.37, P < 0.00001), ZGC (RR:1.35, 95%CI 1.23 to 1.48, P < 0.00001), SMI (RR:1.36, 95%CI 1.21 to 1.52, P < 0.00001) can be more effective. The overall quality of the included trials were relatively low, with the limitations of small sample size, inadequate descriptions in randomization, allocation concealment and blinding methods. Conclusions and Relevance: There are evidence that some TCM formulas might help to relieve Bradyarrhythmias. But with the relatively low quality of the clinical trials and mechanism studies, we still need more high-quality researches to verify the conclusions. PMID:29686614