Sample records for allowed direct observation

  1. Video Allows Young Scientists New Ways to Be Seen

    ERIC Educational Resources Information Center

    Park, John C.

    2009-01-01

    Science is frequently a visual endeavor, dependent on direct or indirect observations. Teachers have long employed motion pictures in the science classroom to allow students to make indirect observations, but the capabilities of digital video offer opportunities to engage students in active science learning. Not only can watching a digital video…

  2. Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics.

    PubMed

    Yatsuzuka, Kenji; Sato, Shin-Ichi; Pe, Kathleen Beverly; Katsuda, Yousuke; Takashima, Ippei; Watanabe, Mizuki; Uesugi, Motonari

    2018-06-08

    Here, we developed two pairs of high-contrast chemical probes and their RNA aptamers with distinct readout channels that permitted simultaneous live-cell imaging of endogenous β-actin and cortactin mRNAs. Application of this technology allowed the direct observation of the formation process of stress granules, protein-RNA assemblies essential for cellular response to the environment.

  3. Direct observation of the protonation of acetone ketyl radical by conductometric pulse radiolysis. [8-MeV electrons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Janata, E.; Schuler, R.H.

    1980-12-11

    Improvements in conductometric pulse radiolysis methods allow direct observation of the protonation of the acetone ketyl radical anion on the 10-ns time scale. The protonation period of 9.7 +- 0.5 ns determined here is in good agreement with that estimated from the ESR line broadening studies of Laroff and Fessenden, (J. Phys. Chem., 77, 1283(1973)).

  4. An Observation Knowledgebase for Hinode Data

    NASA Astrophysics Data System (ADS)

    Hurlburt, Neal E.; Freeland, S.; Green, S.; Schiff, D.; Seguin, R.; Slater, G.; Cirtain, J.

    2007-05-01

    We have developed a standards-based system for the Solar Optical and X Ray Telescopes on the Hinode orbiting solar observatory which can serve as part of a developing Heliophysics informatics system. Our goal is to make the scientific data acquired by Hinode more accessible and useful to scientists by allowing them to do reasoning and flexible searches on observation metadata and to ask higher-level questions of the system than previously allowed. The Hinode Observation Knowledgebase relates the intentions and goals of the observation planners (as-planned metadata) with actual observational data (as-run metadata), along with connections to related models, data products and identified features (follow-up metadata) through a citation system. Summaries of the data (both as image thumbnails and short "film strips") serve to guide researchers to the observations appropriate for their research, and these are linked directly to the data catalog for easy extraction and delivery. The semantic information of the observation (Field of view, wavelength, type of observable, average cadence etc.) is captured through simple user interfaces and encoded using the VOEvent XML standard (with the addition of some solar-related extensions). These interfaces merge metadata acquired automatically during both mission planning and an data analysis (see Seguin et. al. 2007 at this meeting) phases with that obtained directly from the planner/analyst and send them to be incorporated into the knowledgebase. The resulting information is automatically rendered into standard categories based on planned and recent observations, as well as by popularity and recommendations by the science team. They are also directly searchable through both and web-based searches and direct calls to the API. Observations details can also be rendered as RSS, iTunes and Google Earth interfaces. The resulting system provides a useful tool to researchers and can act as a demonstration for larger, more complex systems.

  5. Interplanetary and Interstellar Dust Observed by the Wind/WAVES Electric Field Instrument

    NASA Technical Reports Server (NTRS)

    Malaspina, David; Horanyi, M.; Zaslavsky, A.; Goetz, K.; Wilson, L. B., III; Kersten, K.

    2014-01-01

    Observations of hypervelocity dust particles impacting the Wind spacecraft are reported here for the first time using data from the WindWAVES electric field instrument. A unique combination of rotating spacecraft, amplitude-triggered high-cadence waveform collection, and electric field antenna configuration allow the first direct determination of dust impact direction by any spacecraft using electric field data. Dust flux and impact direction data indicate that the observed dust is approximately micron-sized with both interplanetary and interstellar populations. Nanometer radius dust is not detected by Wind during times when nanometer dust is observed on the STEREO spacecraft and both spacecraft are in close proximity. Determined impact directions suggest that interplanetary dust detected by electric field instruments at 1 AU is dominated by particles on bound trajectories crossing Earths orbit, rather than dust with hyperbolic orbits.

  6. Effects of Structure and Hydrodynamics on the Sooting Behavior of Spherical Microgravity Diffusion Flames

    NASA Technical Reports Server (NTRS)

    Sunderland, P. B.; Axelbaum, Richard L.; Urban, D. L.

    2000-01-01

    We have examined the sooting behavior of spherical microgravity diffusion flames burning ethylene at atmospheric pressure in the NASA Glenn 2.2-second drop tower. In a novel application of microgravity, spherical flames allowed convection across the flame to be either from fuel to oxidizer or from oxidizer to fuel. Thus, microgravity flames are uniquely capable of allowing independent variation of convection direction across the flame and stoichiometric mixture fraction, Z(sub st). This allowed us to determine the dominant mechanism responsible for the phenomenon of permanently-blue diffusion flames -- flames that remain blue as strain rate approaches zero. Stoichiometric mixture fraction was varied by changing inert concentrations such that adiabatic flame temperature did not change. At low and high Z(sub st) nitrogen was supplied with the oxidizer and the fuel, respectively. For the present flames, structure (Z(sub st)) was found to have a profound effect on soot production. Soot-free conditions were observed at high Z(sub st) (Z(sub st) = 0.78) and sooting conditions were observed at low Z(sub st) (Z(sub st) = 0.064) regardless of the direction of convection. Convection direction was found to have a lesser impact on soot inception, with formation being suppressed when convection at the flame sheet was directed towards the oxidizer.

  7. The VAMPIRES instrument: imaging the innermost regions of protoplanetary discs with polarimetric interferometry

    NASA Astrophysics Data System (ADS)

    Norris, Barnaby; Schworer, Guillaume; Tuthill, Peter; Jovanovic, Nemanja; Guyon, Olivier; Stewart, Paul; Martinache, Frantz

    2015-03-01

    Direct imaging of protoplanetary discs promises to provide key insight into the complex sequence of processes by which planets are formed. However, imaging the innermost region of such discs (a zone critical to planet formation) is challenging for traditional observational techniques (such as near-IR imaging and coronagraphy) due to the relatively long wavelengths involved and the area occulted by the coronagraphic mask. Here, we introduce a new instrument - Visible Aperture-Masking Polarimetric Interferometer for Resolving Exoplanetary Signatures (VAMPIRES) - which combines non-redundant aperture-masking interferometry with differential polarimetry to directly image this previously inaccessible innermost region. By using the polarization of light scattered by dust in the disc to provide precise differential calibration of interferometric visibilities and closure phases, VAMPIRES allows direct imaging at and beyond the telescope diffraction limit. Integrated into the SCExAO (Subaru Coronagraphic Extreme Adaptive Optics) system at the Subaru telescope, VAMPIRES operates at visible wavelengths (where polarization is high) while allowing simultaneous infrared observations conducted by HICIAO. Here, we describe the instrumental design and unique observing technique and present the results of the first on-sky commissioning observations, validating the excellent visibility and closure-phase precision which are then used to project expected science performance metrics.

  8. Identification of a localized core mode in a helicon plasma

    NASA Astrophysics Data System (ADS)

    Green, Daniel A.; Chakraborty Thakur, Saikat; Tynan, George R.; Light, Adam D.

    2017-10-01

    We present imaging measurements of a newly observed mode in the core of the Controlled Shear Decorrelation Experiment - Upgrade (CSDX-U). CSDX-U is a well-characterized linear machine producing dense plasmas relevant to the tokamak edge (Te 3 eV, ne 1013 /cc). Typical fluctuations are dominated by electron drift waves, with evidence for Kelvin-Helmholtz vortices appearing near the plasma edge. A new mode has been observed using high-speed imaging that appears at high magnetic field strengths and is confined to the inner third of the plasma column. A cross-spectral phase technique allows direct visualization of dominant spatial structures as a function of frequency. Experimental dispersion curve estimates are constructed from imaging data alone, and allow direct comparison of theoretical dispersion relations to the observed mode. We present preliminary identification of the mode based on its dispersion curve, and compare the results with electrostatic probe measurements.

  9. A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution.

    PubMed

    Hasegawa, Sumitaka; Maruyama, Kouichi; Takenaka, Hikaru; Furukawa, Takako; Saga, Tsuneo

    2009-08-18

    The recent success with small fish as an animal model of cancer with the aid of fluorescence technique has attracted cancer modelers' attention because it would be possible to directly visualize tumor cells in vivo in real time. Here, we report a medaka model capable of allowing the observation of various cell behaviors of transplanted tumor cells, such as cell proliferation and metastasis, which were visualized easily in vivo. We established medaka melanoma (MM) cells stably expressing GFP and transplanted them into nonirradiated and irradiated medaka. The tumor cells were grown at the injection sites in medaka, and the spatiotemporal changes were visualized under a fluorescence stereoscopic microscope at a cellular-level resolution, and even at a single-cell level. Tumor dormancy and metastasis were also observed. Interestingly, in irradiated medaka, accelerated tumor growth and metastasis of the transplanted tumor cells were directly visualized. Our medaka model provides an opportunity to visualize in vivo tumor cells "as seen in a culture dish" and would be useful for in vivo tumor cell biology.

  10. Photocrystallographic observation of halide-bridged intermediates in halogen photoeliminations.

    PubMed

    Powers, David C; Anderson, Bryce L; Hwang, Seung Jun; Powers, Tamara M; Pérez, Lisa M; Hall, Michael B; Zheng, Shao-Liang; Chen, Yu-Sheng; Nocera, Daniel G

    2014-10-29

    Polynuclear transition metal complexes, which frequently constitute the active sites of both biological and chemical catalysts, provide access to unique chemical transformations that are derived from metal-metal cooperation. Reductive elimination via ligand-bridged binuclear intermediates from bimetallic cores is one mechanism by which metals may cooperate during catalysis. We have established families of Rh2 complexes that participate in HX-splitting photocatalysis in which metal-metal cooperation is credited with the ability to achieve multielectron photochemical reactions in preference to single-electron transformations. Nanosecond-resolved transient absorption spectroscopy, steady-state photocrystallography, and computational modeling have allowed direct observation and characterization of Cl-bridged intermediates (intramolecular analogues of classical ligand-bridged intermediates in binuclear eliminations) in halogen elimination reactions. On the basis of these observations, a new class of Rh2 complexes, supported by CO ligands, has been prepared, allowing for the isolation and independent characterization of the proposed halide-bridged intermediates. Direct observation of halide-bridged structures establishes binuclear reductive elimination as a viable mechanism for photogenerating energetic bonds.

  11. Using thermal phase curves to probe the climate of potentially habitable planets

    NASA Astrophysics Data System (ADS)

    Kataria, Tiffany

    2018-01-01

    Thermal phase-curve observations probe the variation in emitted flux of a planet with phase, or longitude. When conducted spectroscopically, they allow us to probe the two-dimensional temperature structure in both longitude and altitude, which directly relate to the planet’s circulation and chemistry. In the case of small, potentially habitable exoplanets, spectroscopic phase-curve observations can provide us with direct evidence that the planet is capable of sustaining liquid water from measurements of its brightness temperature, and allow us to distinguish between a ‘airless’ body and one that has an appreciable atmosphere. In this talk I will summarize efforts to characterize exoplanets smaller than Neptune with phase-curve observations and emission spectroscopy using the Spitzer and Hubble Space Telescopes. I will then discuss how these ‘lessons learned’ can be applied to future efforts to characterize potentially habitable planets with phase-curve observations using JWST and future facilities such as the Origins Space Telescope (OST).

  12. Stimulus learning and response learning by observation in the European starling, in a two-object/two-action test.

    PubMed

    Campbell; Heyes; Goldsmith

    1999-07-01

    Juvenile European starlings, Sturnus vulgaris, were allowed to observe a conspecific demonstrator using its beak to remove one of two distinctively coloured objects (i.e. a red or a black plug) from a hole in the lid of a plastic box. Both plugs could be removed by either pulling up on a loop of string inserted through the centre of the plug, or pushing down on the plug. When subsequently allowed access to the plugs, and rewarded with food for all removal responses, regardless of the object to which they were made and their direction, observer birds removed the same plug in the same direction as their demonstrator. These results suggest that the two-object/two-action paradigm is a valuable procedure for testing for the simultaneous effects of learning about a stimulus and a response, an object and an action, through conspecific observation. Copyright 1999 The Association for the Study of Animal Behaviour.

  13. Observation of partial relaxation mechanisms via anisotropic strain relief on epitaxial islands using semiconductor nanomembranes

    NASA Astrophysics Data System (ADS)

    Rosa, Barbara L. T.; Marçal, Lucas A. B.; Ribeiro Andrade, Rodrigo; Dornellas Pinto, Luciana; Rodrigues, Wagner N.; Lustoza Souza, Patrícia; Pamplona Pires, Mauricio; Wagner Nunes, Ricardo; Malachias, Angelo

    2017-07-01

    In this work we attempt to directly observe anisotropic partial relaxation of epitaxial InAs islands using transmission electron microscopy (TEM) and synchrotron x-ray diffraction on a 15 nm thick InAs:GaAs nanomembrane. We show that under such conditions TEM provides improved real-space statistics, allowing the observation of partial relaxation processes that were not previously detected by other techniques or by usual TEM cross section images. Besides the fully coherent and fully relaxed islands that are known to exist above previously established critical thickness, we prove the existence of partially relaxed islands, where incomplete 60° half-loop misfit dislocations lead to a lattice relaxation along one of the <110> directions, keeping a strained lattice in the perpendicular direction. Although individual defects cannot be directly observed, their implications to the resulting island registry are identified and discussed within the frame of half-loops propagations.

  14. Observation of partial relaxation mechanisms via anisotropic strain relief on epitaxial islands using semiconductor nanomembranes.

    PubMed

    Rosa, Barbara L T; Marçal, Lucas A B; Andrade, Rodrigo Ribeiro; Pinto, Luciana Dornellas; Rodrigues, Wagner N; Souza, Patrícia Lustoza; Pires, Mauricio Pamplona; Nunes, Ricardo Wagner; Malachias, Angelo

    2017-07-28

    In this work we attempt to directly observe anisotropic partial relaxation of epitaxial InAs islands using transmission electron microscopy (TEM) and synchrotron x-ray diffraction on a 15 nm thick InAs:GaAs nanomembrane. We show that under such conditions TEM provides improved real-space statistics, allowing the observation of partial relaxation processes that were not previously detected by other techniques or by usual TEM cross section images. Besides the fully coherent and fully relaxed islands that are known to exist above previously established critical thickness, we prove the existence of partially relaxed islands, where incomplete 60° half-loop misfit dislocations lead to a lattice relaxation along one of the 〈110〉 directions, keeping a strained lattice in the perpendicular direction. Although individual defects cannot be directly observed, their implications to the resulting island registry are identified and discussed within the frame of half-loops propagations.

  15. Assessing Preschool Children's Physical Activity: The Observational System for Recording Physical Activity in Children-Preschool Version

    ERIC Educational Resources Information Center

    Brown, William H.; Pfeiffer, Karin A.; McIver, Kerry L.; Dowda, Marsha; Almeida, M. Joao C. A.; Pate, Russell R.

    2006-01-01

    In this paper we present initial information concerning a new direct observation system--the Observational System for Recording Physical Activity in Children-Preschool Version. The system will allow researchers to record young children's physical activity levels while also coding the topography of their physical activity, as well as detailed…

  16. Seeing mountains in mole hills: geographical-slant perception

    NASA Technical Reports Server (NTRS)

    Proffitt, D. R.; Creem, S. H.; Zosh, W. D.; Kaiser, M. K. (Principal Investigator)

    2001-01-01

    When observers face directly toward the incline of a hill, their awareness of the slant of the hill is greatly overestimated, but motoric estimates are much more accurate. The present study examined whether similar results would be found when observers were allowed to view the side of a hill. Observers viewed the cross-sections of hills in real (Experiment 1) and virtual (Experiment 2) environments and estimated the inclines with verbal estimates, by adjusting the cross-section of a disk, and by adjusting a board with their unseen hand to match the inclines. We found that the results for cross-section viewing replicated those found when observers directly face the incline. Even though the angles of hills are directly evident when viewed from the side, slant perceptions are still grossly overestimated.

  17. A Springloaded Metal-Ligand Mesocate Allows Access to Trapped Intermediates of Self-Assembly.

    PubMed

    Bogie, Paul M; Holloway, Lauren R; Lyon, Yana; Onishi, Nicole C; Beran, Gregory J O; Julian, Ryan R; Hooley, Richard J

    2018-04-02

    A strained, "springloaded" Fe 2 L 3 iminopyridine mesocate shows highly variable reactivity upon postassembly reaction with competitive diamines. The strained assembly is reactive toward transimination in minutes at ambient temperature and allows observation of kinetically trapped intermediates in the self-assembly pathway. When diamines are used that can only form less favored cage products upon full equilibration, trapped ML 3 fragments with pendant, "hanging" NH 2 groups are selectively formed instead. Slight variations in diamine structure have large effects on the product outcome: less rigid diamines convert the mesocate to more favored self-assembled cage complexes under mild conditions and allow observation of heterocomplex intermediates in the displacement pathway. The mesocate allows control of equilibrium processes and direction of product outcomes via small, iterative changes in added subcomponent structure and provides a method of accessing metal-ligand cage structures not normally observed in multicomponent Fe-iminopyridine self-assembly.

  18. Automated Detection of Repetitive Motor Behaviors as an Outcome Measurement in Intellectual and Developmental Disabilities

    ERIC Educational Resources Information Center

    Gilchrist, Kristin H.; Hegarty-Craver, Meghan; Christian, Robert B.; Grego, Sonia; Kies, Ashley C.; Wheeler, Anne C.

    2018-01-01

    Repetitive sensory motor behaviors are a direct target for clinical treatment and a potential treatment endpoint for individuals with intellectual or developmental disabilities. By removing the burden associated with video annotation or direct observation, automated detection of stereotypy would allow for longer term monitoring in ecologic…

  19. Comparison of Terrestrial Gamma Ray Flash Simulations with Observations by Fermi

    DTIC Science & Technology

    2016-10-31

    allowing a direction comparison between the gamma rays measured in low -Earth orbit and the VLF-LF radio frequency emissions recorded on the ground...directly calculated from X and its time derivative, including the gamma-ray emission rate, the current moment, and the optical power of the TGF. For

  20. Predicted and observed directional dependence of meteoroid/debris impacts on LDEF thermal blankets

    NASA Technical Reports Server (NTRS)

    Drolshagen, Gerhard

    1993-01-01

    The number of impacts from meteoroids and space debris particles to the various LDEF rows is calculated using ESABASE/DEBRIS, a 3-D numerical analysis tool. It is based on recent reference environment flux models and includes geometrical and directional effects. A comparison of model predictions and actual observations is made for penetrations of the thermal blankets which covered the UHCR experiment. The thermal blankets were located on all LDEF rows, except 3, 9, and 12. Because of their uniform composition and thickness, these blankets allow a direct analysis of the directional dependence of impacts and provide a test case for the latest meteoroid and debris flux models.

  1. Tidal analysis of Met rocket wind data

    NASA Technical Reports Server (NTRS)

    Bedinger, J. F.; Constantinides, E.

    1976-01-01

    A method of analyzing Met Rocket wind data is described. Modern tidal theory and specialized analytical techniques were used to resolve specific tidal modes and prevailing components in observed wind data. A representation of the wind which is continuous in both space and time was formulated. Such a representation allows direct comparison with theory, allows the derivation of other quantities such as temperature and pressure which in turn may be compared with observed values, and allows the formation of a wind model which extends over a broader range of space and time. Significant diurnal tidal modes with wavelengths of 10 and 7 km were present in the data and were resolved by the analytical technique.

  2. Entropy generation across Earth's collisionless bow shock.

    PubMed

    Parks, G K; Lee, E; McCarthy, M; Goldstein, M; Fu, S Y; Cao, J B; Canu, P; Lin, N; Wilber, M; Dandouras, I; Réme, H; Fazakerley, A

    2012-02-10

    Earth's bow shock is a collisionless shock wave but entropy has never been directly measured across it. The plasma experiments on Cluster and Double Star measure 3D plasma distributions upstream and downstream of the bow shock allowing calculation of Boltzmann's entropy function H and his famous H theorem, dH/dt≤0. The collisionless Boltzmann (Vlasov) equation predicts that the total entropy does not change if the distribution function across the shock becomes nonthermal, but it allows changes in the entropy density. Here, we present the first direct measurements of entropy density changes across Earth's bow shock and show that the results generally support the model of the Vlasov analysis. These observations are a starting point for a more sophisticated analysis that includes 3D computer modeling of collisionless shocks with input from observed particles, waves, and turbulences.

  3. The Myth of Spatial Reuse with Directional Antennas in Indoor Wireless Networks

    NASA Astrophysics Data System (ADS)

    Lakshmanan, Sriram; Sundaresan, Karthikeyan; Rangarajan, Sampath; Sivakumar, Raghupathy

    Interference among co-channel users is a fundamental problem in wireless networks, which prevents nearby links from operating concurrently. Directional antennas allow the radiation patterns of wireless transmitters to be shaped to form directed beams. Conventionally, such beams are assumed to improve the spatial reuse (i.e. concurrency) in indoor wireless networks. In this paper, we use experiments in an indoor office setting of Wifi Access points equipped with directional antennas, to study their potential for interference mitigation and spatial reuse. In contrast to conventional wisdom, we observe that the interference mitigation benefits of directional antennas are minimal. On analyzing our experimental traces we observe that directional links do not reduce interference to nearby links due to the lack of signal confinement due to indoor multipath fading. We then use the insights derived from our study to develop an alternative approach that provides better interference reduction in indoor networks compared to directional links.

  4. Nano-structured wild moth cocoon fibers as radiative cooling and waveguiding optical materials

    NASA Astrophysics Data System (ADS)

    Shi, Norman Nan; Tsai, Cheng-Chia; Bernard, Gary D.; Craig, Catherine; Yu, Nanfang

    2017-09-01

    The study shows that comet moth cocoon fibers exhibit radiative cooing properties with enhanced solar reflectivity and thermal emissivity. Nanostructured voids inside the cocoon fiber enables the cocoons to exhibit strong scattering in the visible and near-infrared. These structures also allow the fibers to exhibit strong shape birefringence and directional reflectivity. Optical waveguiding due to transverse Anderson localization is observed in these natural fibers, where the invariance and large concentration of the voids in the longitudinal direction allow the fiber to confine light in the transverse direction. To mimic the optical effects generated by these natural silk fibers, nanostructured voids are introduced into regenerated silk fibers through wet spinning to enhance reflectivity in the solar spectrum.

  5. Ground truth management system to support multispectral scanner /MSS/ digital analysis

    NASA Technical Reports Server (NTRS)

    Coiner, J. C.; Ungar, S. G.

    1977-01-01

    A computerized geographic information system for management of ground truth has been designed and implemented to relate MSS classification results to in situ observations. The ground truth system transforms, generalizes and rectifies ground observations to conform to the pixel size and shape of high resolution MSS aircraft data. These observations can then be aggregated for comparison to lower resolution sensor data. Construction of a digital ground truth array allows direct pixel by pixel comparison between classification results of MSS data and ground truth. By making comparisons, analysts can identify spatial distribution of error within the MSS data as well as usual figures of merit for the classifications. Use of the ground truth system permits investigators to compare a variety of environmental or anthropogenic data, such as soil color or tillage patterns, with classification results and allows direct inclusion of such data into classification operations. To illustrate the system, examples from classification of simulated Thematic Mapper data for agricultural test sites in North Dakota and Kansas are provided.

  6. Direct Observation of Individual Charges and Their Dynamics on Graphene by Low-Energy Electron Holography.

    PubMed

    Latychevskaia, Tatiana; Wicki, Flavio; Longchamp, Jean-Nicolas; Escher, Conrad; Fink, Hans-Werner

    2016-09-14

    Visualizing individual charges confined to molecules and observing their dynamics with high spatial resolution is a challenge for advancing various fields in science, ranging from mesoscopic physics to electron transfer events in biological molecules. We show here that the high sensitivity of low-energy electrons to local electric fields can be employed to directly visualize individual charged adsorbates and to study their behavior in a quantitative way. This makes electron holography a unique probing tool for directly visualizing charge distributions with a sensitivity of a fraction of an elementary charge. Moreover, spatial resolution in the nanometer range and fast data acquisition inherent to lens-less low-energy electron holography allows for direct visual inspection of charge transfer processes.

  7. Frequency tuning allows flow direction control in microfluidic networks with passive features.

    PubMed

    Jain, Rahil; Lutz, Barry

    2017-05-02

    Frequency tuning has emerged as an attractive alternative to conventional pumping techniques in microfluidics. Oscillating (AC) flow driven through a passive valve can be rectified to create steady (DC) flow, and tuning the excitation frequency to the characteristic (resonance) frequency of the underlying microfluidic network allows control of flow magnitude using simple hardware, such as an on-chip piezo buzzer. In this paper, we report that frequency tuning can also be used to control the direction (forward or backward) of the rectified DC flow in a single device. Initially, we observed that certain devices provided DC flow in the "forward" direction expected from previous work with a similar valve geometry, and the maximum DC flow occurred at the same frequency as a prominent peak in the AC flow magnitude, as expected. However, devices of a slightly different geometry provided the DC flow in the opposite direction and at a frequency well below the peak AC flow. Using an equivalent electrical circuit model, we found that the "forward" DC flow occurred at the series resonance frequency (with large AC flow peak), while the "backward" DC flow occurred at a less obvious parallel resonance (a valley in AC flow magnitude). We also observed that the DC flow occurred only when there was a measurable differential in the AC flow magnitude across the valve, and the DC flow direction was from the channel with large AC flow magnitude to that with small AC flow magnitude. Using these observations and the AC flow predictions from the equivalent circuit model, we designed a device with an AC flowrate frequency profile that was expected to allow the DC flow in opposite directions at two distinct frequencies. The fabricated device showed the expected flow reversal at the expected frequencies. This approach expands the flow control toolkit to include both magnitude and direction control in frequency-tuned microfluidic pumps. The work also raises interesting questions about the origin of flow reversal behavior that may be addressed by the further study of the circuit model behavior or dynamic modeling of the fluid-solid mechanics of the valve under the AC flow.

  8. Exploring small bodies in the outer solar system with stellar occultations

    NASA Technical Reports Server (NTRS)

    Elliot, Jim L.; Dunham, Edward W.; Olkin, C. B.

    1995-01-01

    Stellar occultation observations probe the atmospheric structure and extinction of outer solar system bodies with a spatial resolution of a few kilometers, and an airborne platform allows the observation of occultations by small bodies that are not visible from fixed telescopes. Results from occultations by Triton, Pluto, and Chiron observed with KAO are discussed, and future directions for this program are presented.

  9. Land observation from geosynchronous earth orbit (LOGEO): Mission concept and preliminary engineering analysis

    NASA Astrophysics Data System (ADS)

    Román-Colón, Miguel O.; Strahler, Alan H.

    2007-06-01

    We propose an Earth-observation mission Land Observation from Geosynchronous Earth Orbit (LOGEO) to place two spin-scan-stabilized 500-m resolution 9-band VNIR-SWIR imagers in a near-geosynchronous inclined orbit, allowing 15 min observations with a full range of daily sun angles and 30∘ variations in view angle. LOGEO drifts westward at about 4∘ per day, providing geostationary-style coverage for all points on the globe eight times per year. This unique imaging geometry allows accurate retrievals of daily changes in surface bidirectional reflectance, which in turn enhances direct retrieval of biophysical properties, as well as long term and consistent land surface parameters for modeling studies that seek to understand the Earth system and its interactions. For studies of climate and environmental dynamics, LOGEO provides accurate observations of atmospheric aerosols, clouds, as well as other atmospheric constituents across a diverse number of spatial and temporal scales. This collection of land, atmospheric, and climate data products are directly applicable to seven of the nine GEOSS societal benefits areas, providing great opportunities for international collaboration. We also present an overview of LOGEO's systems architecture, as well as top-level design-trade studies and orbital scenarios.

  10. Soil Moisture Controls on Rainfall and Temperature Variability: A Modeler Searches Through Observational Data

    NASA Technical Reports Server (NTRS)

    Koster, Randal

    2010-01-01

    The degree to which atmospheric processes respond to variations in soil moisture - a potentially important but largely untapped element of subseasonal to seasonal prediction - can be determined easily and directly for an atmospheric model but cannot be determined directly for nature through an analysis of observations. In atmospheric models) directions of causality can be artificially manipulated; we can avoid difficulties associated with the fact that atmospheric variations have a much larger impact on land state variations than vice-versa. In nature) on the other hand) the dominant direction of causality (the atmosphere forcing the ground) cannot be artificially "turned off") and the statistics associated with this dominant direction overwhelm those of the feedback signal. Observational data) however) do allow a number of indirect measures of landatmosphere feedback. This seminar reports on a series of joint analyses of observational and model data designed to illuminate the degree of land-atmosphere feedback present in the real world. The indirect measures do in fact suggest that feedback in nature, though small) is significant - enough to warrant the development of realistic land initialization strategies for subseasonal and seasonal forecasts.

  11. Geometrical control of pure spin current induced domain wall depinning.

    PubMed

    Pfeiffer, A; Reeve, R M; Voto, M; Savero-Torres, W; Richter, N; Vila, L; Attané, J P; Lopez-Diaz, L; Kläui, Mathias

    2017-03-01

    We investigate the pure spin-current assisted depinning of magnetic domain walls in half ring based Py/Al lateral spin valve structures. Our optimized geometry incorporating a patterned notch in the detector electrode, directly below the Al spin conduit, provides a tailored pinning potential for a transverse domain wall and allows for a precise control over the magnetization configuration and as a result the domain wall pinning. Due to the patterned notch, we are able to study the depinning field as a function of the applied external field for certain applied current densities and observe a clear asymmetry for the two opposite field directions. Micromagnetic simulations show that this can be explained by the asymmetry of the pinning potential. By direct comparison of the calculated efficiencies for different external field and spin current directions, we are able to disentangle the different contributions from the spin transfer torque, Joule heating and the Oersted field. The observed high efficiency of the pure spin current induced spin transfer torque allows for a complete depinning of the domain wall at zero external field for a charge current density of [Formula: see text] A m -2 , which is attributed to the optimal control of the position of the domain wall.

  12. Observing the epoch of galaxy formation.

    PubMed

    Steidel, C C

    1999-04-13

    Significant observational progress in addressing the question of the origin and early evolution of galaxies has been made in the past few years, allowing for direct comparison of the epoch when most of the stars in the universe were forming to prevailing theoretical models. There is currently broad consistency between theoretical expectations and the observations, but rapid improvement in the data will provide much more critical tests of theory in the coming years.

  13. Observing the epoch of galaxy formation

    PubMed Central

    Steidel, Charles C.

    1999-01-01

    Significant observational progress in addressing the question of the origin and early evolution of galaxies has been made in the past few years, allowing for direct comparison of the epoch when most of the stars in the universe were forming to prevailing theoretical models. There is currently broad consistency between theoretical expectations and the observations, but rapid improvement in the data will provide much more critical tests of theory in the coming years. PMID:10200244

  14. Cosmic-ray anisotropy studies with IceCube

    NASA Astrophysics Data System (ADS)

    McNally, Frank

    2014-03-01

    The IceCube neutrino observatory detects tens of billions of energetic muons per year produced by cosmic-ray interactions with the atmosphere. The size of this sample has allowed IceCube to observe a significant anisotropy in arrival direction for cosmic rays with median energies between 20 and 400 TeV. This anisotropy is characterized by a large scale structure of per-mille amplitude accompanied by structures with smaller amplitudes and with typical angular sizes between 10° and 20°. IceTop, the surface component of IceCube, has observed a similar anisotropy in the arrival direction distribution of cosmic rays, extending the study to PeV energies. The better energy resolution of IceTop allows for additional studies of the anisotropy, for example a comparison of the energy spectrum in regions of a cosmic-ray excess or deficit to the rest of the sky. We present an update on the cosmic-ray anisotropy observed with IceCube and IceTop and the results of first studies of the energy spectrum at locations of cosmic-ray excess or deficit.

  15. Ultrafast observation of lattice dynamics in laser-irradiated gold foils

    DOE PAGES

    Hartley, N. J.; Ozaki, Norimasa; Matsuoka, T.; ...

    2017-02-13

    Here, we have observed the lattice expansion before the onset of compression in an optical-laser-driven target, using diffraction of femtosecond X-ray beams generated by the SPring-8 Angstrom Compact Free-electron Laser. The change in diffraction angle provides a direct measure of the lattice spacing, allowing the density to be calculated with a precision of ±1%. From the known equation of state relations, this allows an estimation of the temperature responsible for the expansion as <1000 K. The subsequent ablation-driven compression was observed with a clear rise in density at later times. This demonstrates the feasibility of studying the dynamics of preheatingmore » and shock formation with unprecedented detail.« less

  16. Ultrafast observation of lattice dynamics in laser-irradiated gold foils

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hartley, N. J.; Ozaki, Norimasa; Matsuoka, T.

    Here, we have observed the lattice expansion before the onset of compression in an optical-laser-driven target, using diffraction of femtosecond X-ray beams generated by the SPring-8 Angstrom Compact Free-electron Laser. The change in diffraction angle provides a direct measure of the lattice spacing, allowing the density to be calculated with a precision of ±1%. From the known equation of state relations, this allows an estimation of the temperature responsible for the expansion as <1000 K. The subsequent ablation-driven compression was observed with a clear rise in density at later times. This demonstrates the feasibility of studying the dynamics of preheatingmore » and shock formation with unprecedented detail.« less

  17. Be/X-Ray Pulsar Binary Science with LOFT

    NASA Technical Reports Server (NTRS)

    Wilson-Hodge, Colleen A.

    2011-01-01

    Accretion disks are ubiquitous in astronomical sources. Accretion powered pulsars are a good test bed for accretion disk physics, because unlike for other objects, the spin of the neutron star is directly observable allowing us to see the effects of angular momentum transfer onto the pulsar. The combination of a sensitive wide-field monitor and the large area detector on LOFT will enable new detailed studies of accretion powered pulsars which I will review. RXTE observations have shown an unusually high number of Be/X-ray pulsar binaries in the SMC. Unlike binaries in the Milky Way, these systems are all at the same distance, allowing detailed population studies using the sensitive LOFT WFM, potentially providing connections to star formation episodes. For Galactic accreting pulsar systems, LOFT will allow measurement of spectral variations within individual pulses, mapping the accretion column in detail for the first time. LOFT will also provide better constraints on magnetic fields in accreting pulsars, allowing measurements of cyclotron features, observations of transitions into the centrifugal inhibition regime, and monitoring of spin-up rate vs flux correlations. Coordinated multi-wavelength observations are crucial to extracting the best science from LOFT from these and numerous other objects.

  18. Breast Cancer Tissue Bioreactor for Direct Interrogation and Observation of Response to Antitumor Therapies

    DTIC Science & Technology

    2011-07-01

    into the bioreactor . Cell lines were cultured in low density 3D matrigel conditions. Mammoshere formation is dependent upon a number of...epithelial cell culture systems grown under 3D cell culture conditions that allow for mammosphere or glandular mammary acinar development. Drug...assessed whether lowering the dose would still be affective as a extracellular matrix inhibitor. For 3D cell cultures , mammospheres were allowed to

  19. Predicted and observed directional dependence of meteoroid/debris impacts on LDEF thermal blankets

    NASA Astrophysics Data System (ADS)

    Drolshagen, Gerhard

    1992-06-01

    The number of impacts from meteoroids and space debris particles to the various Long Duration Exposure Facility (LDEF) rows is calculated using ESABASE/DEBRIS, a 3-D numerical analysis tool. It is based on the latest environment flux models and includes geometrical and directional effects. A detailed comparison of model predictions and actual observations is made for impacts on the thermal blankets which covered the USCR experiment. Impact features on these blankets were studied intensively in European laboratories and hypervelocity impacts for calibration were performed. The thermal blankets were located on all LDEF rows, except 3, 9, and 12. Because of their uniform composition and thickness, these blankets allow a direct analysis of the directional dependence of impacts and provide a unique test case for the latest meteoroid and debris flux models.

  20. Twelve-month-old infants recognize that speech can communicate unobservable intentions.

    PubMed

    Vouloumanos, Athena; Onishi, Kristine H; Pogue, Amanda

    2012-08-07

    Much of our knowledge is acquired not from direct experience but through the speech of others. Speech allows rapid and efficient transfer of information that is otherwise not directly observable. Do infants recognize that speech, even if unfamiliar, can communicate about an important aspect of the world that cannot be directly observed: a person's intentions? Twelve-month-olds saw a person (the Communicator) attempt but fail to achieve a target action (stacking a ring on a funnel). The Communicator subsequently directed either speech or a nonspeech vocalization to another person (the Recipient) who had not observed the attempts. The Recipient either successfully stacked the ring (Intended outcome), attempted but failed to stack the ring (Observable outcome), or performed a different stacking action (Related outcome). Infants recognized that speech could communicate about unobservable intentions, looking longer at Observable and Related outcomes than the Intended outcome when the Communicator used speech. However, when the Communicator used nonspeech, infants looked equally at the three outcomes. Thus, for 12-month-olds, speech can transfer information about unobservable aspects of the world such as internal mental states, which provides preverbal infants with a tool for acquiring information beyond their immediate experience.

  1. Twelve-month-old infants recognize that speech can communicate unobservable intentions

    PubMed Central

    Vouloumanos, Athena; Onishi, Kristine H.; Pogue, Amanda

    2012-01-01

    Much of our knowledge is acquired not from direct experience but through the speech of others. Speech allows rapid and efficient transfer of information that is otherwise not directly observable. Do infants recognize that speech, even if unfamiliar, can communicate about an important aspect of the world that cannot be directly observed: a person’s intentions? Twelve-month-olds saw a person (the Communicator) attempt but fail to achieve a target action (stacking a ring on a funnel). The Communicator subsequently directed either speech or a nonspeech vocalization to another person (the Recipient) who had not observed the attempts. The Recipient either successfully stacked the ring (Intended outcome), attempted but failed to stack the ring (Observable outcome), or performed a different stacking action (Related outcome). Infants recognized that speech could communicate about unobservable intentions, looking longer at Observable and Related outcomes than the Intended outcome when the Communicator used speech. However, when the Communicator used nonspeech, infants looked equally at the three outcomes. Thus, for 12-month-olds, speech can transfer information about unobservable aspects of the world such as internal mental states, which provides preverbal infants with a tool for acquiring information beyond their immediate experience. PMID:22826217

  2. Tracking individual membrane proteins and their biochemistry: The power of direct observation.

    PubMed

    Barden, Adam O; Goler, Adam S; Humphreys, Sara C; Tabatabaei, Samaneh; Lochner, Martin; Ruepp, Marc-David; Jack, Thomas; Simonin, Jonathan; Thompson, Andrew J; Jones, Jeffrey P; Brozik, James A

    2015-11-01

    The advent of single molecule fluorescence microscopy has allowed experimental molecular biophysics and biochemistry to transcend traditional ensemble measurements, where the behavior of individual proteins could not be precisely sampled. The recent explosion in popularity of new super-resolution and super-localization techniques coupled with technical advances in optical designs and fast highly sensitive cameras with single photon sensitivity and millisecond time resolution have made it possible to track key motions, reactions, and interactions of individual proteins with high temporal resolution and spatial resolution well beyond the diffraction limit. Within the purview of membrane proteins and ligand gated ion channels (LGICs), these outstanding advances in single molecule microscopy allow for the direct observation of discrete biochemical states and their fluctuation dynamics. Such observations are fundamentally important for understanding molecular-level mechanisms governing these systems. Examples reviewed here include the effects of allostery on the stoichiometry of ligand binding in the presence of fluorescent ligands; the observation of subdomain partitioning of membrane proteins due to microenvironment effects; and the use of single particle tracking experiments to elucidate characteristics of membrane protein diffusion and the direct measurement of thermodynamic properties, which govern the free energy landscape of protein dimerization. The review of such characteristic topics represents a snapshot of efforts to push the boundaries of fluorescence microscopy of membrane proteins to the absolute limit. This article is part of the Special Issue entitled 'Fluorescent Tools in Neuropharmacology'. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Direct observation of cerebrospinal fluid bulk flow in the brain

    NASA Astrophysics Data System (ADS)

    Mestre, Humberto; Tithof, Jeffrey; Thomas, John; Kelley, Douglas; Nedergaard, Maiken

    2017-11-01

    Cerebrospinal fluid (CSF) serves a vital role in normal brain function. Its adequate flow and exchange with interstitial fluid through perivascular spaces (PVS) has been shown to be important in the clearance of toxic metabolites like amyloid- β, and its disturbance can cause severe neurological diseases. It has long been suspected that bulk flow may transport CSF, but limitations in imaging techniques have prevented direct observation of such flows in the PVS. In this talk, we describe a novel approach using high speed two photon laser scanning microscopy which has allowed for the first ever direct observation of CSF flow in the PVS of a mouse brain. By performing particle tracking velocimetry, we quantify the CSF bulk flow speeds and PVS geometry. This technique enables future studies of CSF flow disturbances on a new scale and will pave the way for evaluating the role of these fluxes in neurodegenerative disease. R01NS100366 (to M.N.).

  4. Unveiling the hidden supernova population in local LIRGs with NIR/Radio observations

    NASA Astrophysics Data System (ADS)

    Herrero-Illana, R.; Pérez-Torres, M. A.; Alberdi, A.

    2013-05-01

    The dust enshrouded environments of Luminous Infrared Galaxies (LIRGs), and especially of their nuclear regions, prevents the direct detection of supernovae in the optical. Radio observations are unaffected by dust extinction, allowing for the detection of most of these supernovae, thus probing their massive star formation rate. In addition, complementary observations in the near IR can help us to understand the nature of these phenomena and derive properties of the regions where they occur.

  5. Proton-decaying, light nuclei accessed via the invariant-mass method

    NASA Astrophysics Data System (ADS)

    Brown, Kyle

    2017-01-01

    Two-nucleon decay is the most recently discovered nuclear decay mode. For proton-rich nuclei, the majority of multi-proton decays occur via sequential steps of one-proton emission. Direct two-proton (2p) decay was believed to occur only in even-Z nuclei beyond the proton drip line where one-proton decay is energy forbidden. This has been observed for the ground states of around a dozen nuclei including 6Be, the lightest case, and 54Zn, the heaviest case. Direct 2p decay has also recently been observed for isobaric analog states where all possible 1p intermediates are either isospin allowed and energy forbidden, or energy-allowed and isospin forbidden. For light proton emitters, the lifetimes are short enough that the invariant-mass technique is ideal for measuring the decay energy, intrinsic width and, for multi-proton decays, the momentum correlations between the fragments. I will describe recent measurements of proton emitters using the invariant-mass technique with the High Resolution Array (HiRA). I will present a new, high-statistics measurement on the sequential 2p decay of excited states in 17Ne. Measuring the momentum correlations between the decay fragments allow us to determine the 1p intermediate state through which the decay proceeds. I will present data on the isobaric-analog pair 8C and 8BIAS, which highlight the two known types of direct 2p decay. I will also present the first observation of 17Na, which is unbound with respect to three-proton emission. Finally I will present a new measurement on the width of the first-excited state of 9C and compare to recent theoretical calculations.

  6. Structural Equation Models in a Redundancy Analysis Framework With Covariates.

    PubMed

    Lovaglio, Pietro Giorgio; Vittadini, Giorgio

    2014-01-01

    A recent method to specify and fit structural equation modeling in the Redundancy Analysis framework based on so-called Extended Redundancy Analysis (ERA) has been proposed in the literature. In this approach, the relationships between the observed exogenous variables and the observed endogenous variables are moderated by the presence of unobservable composites, estimated as linear combinations of exogenous variables. However, in the presence of direct effects linking exogenous and endogenous variables, or concomitant indicators, the composite scores are estimated by ignoring the presence of the specified direct effects. To fit structural equation models, we propose a new specification and estimation method, called Generalized Redundancy Analysis (GRA), allowing us to specify and fit a variety of relationships among composites, endogenous variables, and external covariates. The proposed methodology extends the ERA method, using a more suitable specification and estimation algorithm, by allowing for covariates that affect endogenous indicators indirectly through the composites and/or directly. To illustrate the advantages of GRA over ERA we propose a simulation study of small samples. Moreover, we propose an application aimed at estimating the impact of formal human capital on the initial earnings of graduates of an Italian university, utilizing a structural model consistent with well-established economic theory.

  7. Selective Attention with Human Earphones.

    ERIC Educational Resources Information Center

    Goodwin, C. James

    1988-01-01

    Describes a method for demonstrating dichotic listening tasks in the classroom which involves substituting live readers for tape recorded messages to allow direct student observation of various selective attention phenomena. Concludes that live readers offer pedagogical benefits that make them superior to tape recorded dichotic listening tasks.…

  8. 49 CFR 192.805 - Qualification program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... include provisions to: (a) Identify covered tasks; (b) Ensure through evaluation that individuals performing covered tasks are qualified; (c) Allow individuals that are not qualified pursuant to this subpart to perform a covered task if directed and observed by an individual that is qualified; (d) Evaluate...

  9. Observation of high-energy gamma-rays with the AMS-02 electromagnetic calorimeter

    NASA Astrophysics Data System (ADS)

    Morescalchi, L.

    2017-05-01

    The Alpha Magnetic Spectrometer (AMS-02) is a multipurpose astroparticle physics detector installed on the International Space Station (ISS). Since more than 5 years it is measuring with an unprecedented accuracy flux and composition of primary cosmic rays, searching for primordial anti-matter and probing the nature of dark matter. Despite the fact that AMS-02 has been primarily designed as a charged-particle spectrometer, it can also perform precision observations of γ -rays from a few GeV to beyond one TeV. The key sub-detector used for the photon identification is a lead-scintillating fibers sampling calorimeter (ECAL). Its high granularity allows to reconstruct the direction of the incoming photon with a resolution better than 1 degree. The 3D shower image reconstructed by the calorimeter together with the absence of hits along the reconstructed photon direction allow to reach a very good signal over background ratio. This experimental technique offers the unusual possibility to reconstruct a sky map of the very high-energy photon sources.

  10. Panoramic Measurement and Analysis of Strain Distribution in the Human ACL Using a Photoelastic Coating Method

    NASA Astrophysics Data System (ADS)

    Hirokawa, Shunji; Yamamoto, Kouji; Kawada, Takashi

    Large and highly variable deformations of the ACL cannot be adequately quantified by one-dimensional and/or localized measurements. Since the complex anatomy of the ACL makes uniform loading of all fiber bundles almost impossible, strains on specific portions being tested are considerably altered during knee movement. To observe the ACL's entire surface, we propose a photoelastic coating method. A simulator jig was used to allow a natural motion of the knee whose medial and lateral femoral bone parts were removed in order to expose the ACL for observation. The simulator jig with the knee was mounted on a universal stand which allows tilt and swivel rotations, so that the exposed ACL might be viewed from any direction. Measurements were performed on the strain distributions over the ACL at various knee angles. The panoramic images of the photoelastic fringe patterns yielded significant results. Special attention was paid for insight into the relation between strain distribution and the directions of fiber run.

  11. Phase from defocus

    NASA Astrophysics Data System (ADS)

    Mandula, Ondrej; Allier, Cédric; Hervé, Lionel; Denarier, Eric; Fourest-Lieuvin, Anne; Gory-Fauré, Sylvie; Vinit, Angélique; Morales, Sophie

    2018-02-01

    We present a simple and compact phase imaging microscope for long-term observation of non-absorbing biological samples such as unstained cells in nutritive media. The phase image is obtained from a single defocused image taken with a standard wide-field microscope. Using a semi-coherent light source allows us to computationally re-focus image post-acquisition and recover both phase and transmission of the complex specimen. The simplicity of the system reduces both the cost and its physical size and allows a long-term observation of samples directly in a standard biological incubator. The low cost of the system can contribute to the democratization of science by allowing to perform complex long-term biological experiments to the laboratories with constrained budget. In this proceeding we present several results taken with our prototype and discuss the possibilities and limitations of our system.

  12. High-resolution imaging of living mammalian cells bound by nanobeads-connected antibodies in a medium using scanning electron-assisted dielectric microscopy

    NASA Astrophysics Data System (ADS)

    Okada, Tomoko; Ogura, Toshihiko

    2017-02-01

    Nanometre-scale-resolution imaging technologies for liquid-phase specimens are indispensable tools in various scientific fields. In biology, observing untreated living cells in a medium is essential for analysing cellular functions. However, nanoparticles that bind living cells in a medium are hard to detect directly using traditional optical or electron microscopy. Therefore, we previously developed a novel scanning electron-assisted dielectric microscope (SE-ADM) capable of nanoscale observations. This method enables observation of intact cells in aqueous conditions. Here, we use this SE-ADM system to clearly observe antibody-binding nanobeads in liquid-phase. We also report the successful direct detection of streptavidin-conjugated nanobeads binding to untreated cells in a medium via a biotin-conjugated anti-CD44 antibody. Our system is capable of obtaining clear images of cellular organelles and beads on the cells at the same time. The direct observation of living cells with nanoparticles in a medium allowed by our system may contribute the development of carriers for drug delivery systems (DDS).

  13. Evidence of Momentum Conservation at a Nonepitaxial Metal/Semiconductor Interface Using Ballistic Electron Emission Microscopy

    NASA Technical Reports Server (NTRS)

    Bell, L. D.

    1996-01-01

    Ballistic-Electron-Emission Microscopy (BEEM) spectroscopy has been performed on Au/Si(111) structures as a function of Au thickness and temperature. At 77 K a direct signature of parallel momentum conservation at the Au/Si interface is observed in the BEEM spectra. The variation in spectral shape with both Au thickness and temperature places restrictions on allowable values of inelastic and elastic mean-free paths in the metal, and also requires the presence of multiple electron passes within the Au layer. An independent indication of multiple reflections is directly observed in the attenuation of BEEM current with Au thickness.

  14. Direct observation of nucleocytoplasmic transport by microinjection of GFP-tagged proteins in living cells.

    PubMed

    Rosorius, O; Heger, P; Stelz, G; Hirschmann, N; Hauber, J; Stauber, R H

    1999-08-01

    We established a straightforward experimental system to investigate directly the requirements for nucleocytoplasmic transport in live cells. For this purpose, substrates were created containing nuclear localization signals (NLS) or nuclear export signals (NES) linked to a chimeric protein composed of the glutathione S-transferase (GST) fused to the green fluorescent protein (GFP). The combination of GST/GFP-tagging allowed us to control protein expression in bacteria and to monitor protein purification during chromatography. Following microinjection into somatic cells, nuclear export/import of the highly fluorescent substrates could be observed directly by fluorescence microscopy. This system sets the stage to quantitate, in real time, the kinetics of nuclear import/export in living cells and to evaluate qualitative differences in various NLS/NES signals and pathways.

  15. Shear-Sensitive Liquid Crystal Coating Method Applied Through Transparent Test Surfaces

    NASA Technical Reports Server (NTRS)

    Reda, Daniel C.; Wilder, Michael C.

    1999-01-01

    Research conducted at NASA Ames Research Center has shown that the color-change response of a shear-sensitive liquid crystal coating (SSLCC) to aerodynamic shear depends on both the magnitude of the local shear vector and its direction relative to the observer's in-plane line of sight. In conventional applications, the surface of the SSLCC exposed to aerodynamic shear is illuminated with white light from the normal direction and observed from an oblique above-plane view angle of order 30 deg. In this top-light/top-view mode, shear vectors with components directed away from the observer cause the SSLCC to exhibit color-change responses. At any surface point, the maximum color change (measured from the no-shear red or orange color) always occurs when the local vector is aligned with, and directed away from, the observer. The magnitude of the color change at this vector-observer-aligned orientation scales directly with shear stress magnitude. Conversely, any surface point exposed to a shear vector with a component directed toward the observer exhibits a non-color-change response, always characterized by a rusty-red or brown color, independent of both shear magnitude and direction. These unique, highly directional color-change responses of SSLCCs to aerodynamic shear allow for the full-surface visualization and measurement of continuous shear stress vector distributions. The objective of the present research was to investigate application of the SSLCC method through a transparent test surface. In this new back-light/back-view mode, the exposed surface of the SSLCC would be subjected to aerodynamic shear stress while the contact surface between the SSLCC and the solid, transparent wall would be illuminated and viewed in the same geometrical arrangement as applied in conventional applications. It was unknown at the outset whether or not color-change responses would be observable from the contact surface of the SSLCC, and, if seen, how these color-change responses might relate to those observed in standard practice.

  16. 49 CFR 195.505 - Qualification program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... that the individual's performance of a covered task contributed to an accident as defined in Part 195... tasks; (b) Ensure through evaluation that individuals performing covered tasks are qualified; (c) Allow individuals that are not qualified pursuant to this subpart to perform a covered task if directed and observed...

  17. A Student Experiment to Demonstrate the Energy Loss and Straggling of Electrons in Matter.

    ERIC Educational Resources Information Center

    de Bruin, M.; Huijgen, F. W. J.

    1990-01-01

    Described is an introductory experiment that allows students to directly observe and measure the linear energy transfer in matter. Illustrated are the experimental setup including the radioactive source, electronic equipment, and the detector; measurement and calculations; and the results. (CW)

  18. The ISO Data Archive and Interoperability with Other Archives

    NASA Astrophysics Data System (ADS)

    Salama, Alberto; Arviset, Christophe; Hernández, José; Dowson, John; Osuna, Pedro

    The ESA's Infrared Space Observatory (ISO), an unprecedented observatory for infrared astronomy launched in November 1995, successfully made nearly 30,000 scientific observations in its 2.5-year mission. The ISO data can be retrieved from the ISO Data Archive, available at ISO Data Archive , and comprised of about 150,000 observations, including parallel and serendipity mode observations. A user-friendly Java interface permits queries to the database and data retrieval. The interface currently offers a wide variety of links to other archives, such as name resolution with NED and SIMBAD, access to electronic articles from ADS and CDS/VizieR, and access to IRAS data. In the past year development has been focused on improving the IDA interoperability with other astronomical archives, either by accessing other relevant archives or by providing direct access to the ISO data for external services. A mechanism of information transfer has been developed, allowing direct query to the IDA via a Java Server Page, returning quick look ISO images and relevant, observation-specific information embedded in an HTML page. This method has been used to link from the CDS/Vizier Data Centre and ADS, and work with IPAC to allow access to the ISO Archive from IRSA, including display capabilities of the observed sky regions onto other mission images, is in progress. Prospects for further links to and from other archives and databases are also addressed.

  19. Flow in the Deep Mantle from Seisimc Anisotropy: Progress and Prospects

    NASA Astrophysics Data System (ADS)

    Long, M. D.

    2017-12-01

    Observations of seismic anisotropy, or the directional dependence of seismic wavespeeds, provide one some of the most direct constraints on the pattern of flow in the Earth's mantle. In particular, as our understanding of crystallographic preferred orientation (CPO) of olivine aggregates under a range of deformation conditions has improved, our ability to exploit observations of upper mantle anisotropy has led to fundamental discoveries about the patterns of flow in the upper mantle and the drivers of that flow. It has been a challenge, however, to develop a similar framework for understanding flow in the deep mantle (transition zone, uppermost lower mantle, and lowermost mantle), even though there is convincing observational evidence for seismic anisotropy at these depths. Recent progress on the observational front has allowed for an increasingly detailed view of mid-mantle anisotropy (transition zone and uppermost lower mantle), particularly in subduction systems, which may eventually lead to a better understanding of mid-mantle deformation and the dynamics of slab interaction with the surrounding mid-mantle. New approaches to the observation and modeling of lowermost mantle anisotropy, in combination with constraints from mineral physics, are progressing towards interpretive frameworks that allow for the discrimination of different mantle flow geometries in different regions of D". In particular, observational strategies that involve the use of multiple types of body wave phases sampled over a range of propagation azimuths enable detailed forward modeling approaches that can discriminate between different mechanisms for D" anisotropy (e.g., CPO of post-perovskite, bridgmanite, or ferropericlase, or shape preferred orientation of partial melt) and identify plausible anisotropic orientations. We have recently begun to move towards a full waveform modeling approach in this work, which allows for a more accurate simulation for seismic wave propagation. Ongoing improvements in seismic observational strategies, experimental and computational mineral physics, and geodynamic modeling approaches are leading to new avenues for understanding flow in the deep mantle through the study of seismic anisotropy.

  20. Examining Student Research Choices and Processes in a Disintermediated Searching Environment

    ERIC Educational Resources Information Center

    Rempel, Hannah Gascho; Buck, Stefanie; Deitering, Anne-Marie

    2013-01-01

    Students today perform research in a disintermediated environment, which often allows them to struggle directly with the process of selecting research tools and choosing scholarly sources. The authors conducted a qualitative study with twenty students, using structured observations to ascertain the processes students use to select databases and…

  1. The Role of the Virtual Microscope in Distance Learning

    ERIC Educational Resources Information Center

    Whalley, Peter; Kelley, Simon; Tindle, Andrew

    2011-01-01

    Screen-based microscopes allow for a shared visualisation and task-directed conversations that offer significant pedagogic advantages for the science disciplines involving observation of natural samples such as the geosciences and biosciences, and particularly for distance education in these disciplines. The role and development of a virtual…

  2. Implementation of a direct-imaging and FX correlator for the BEST-2 array

    NASA Astrophysics Data System (ADS)

    Foster, G.; Hickish, J.; Magro, A.; Price, D.; Zarb Adami, K.

    2014-04-01

    A new digital backend has been developed for the Basic Element for SKA Training II (BEST-2) array at Radiotelescopi di Medicina, INAF-IRA, Italy, which allows concurrent operation of an FX correlator, and a direct-imaging correlator and beamformer. This backend serves as a platform for testing some of the spatial Fourier transform concepts which have been proposed for use in computing correlations on regularly gridded arrays. While spatial Fourier transform-based beamformers have been implemented previously, this is, to our knowledge, the first time a direct-imaging correlator has been deployed on a radio astronomy array. Concurrent observations with the FX and direct-imaging correlator allow for direct comparison between the two architectures. Additionally, we show the potential of the direct-imaging correlator for time-domain astronomy, by passing a subset of beams though a pulsar and transient detection pipeline. These results provide a timely verification for spatial Fourier transform-based instruments that are currently in commissioning. These instruments aim to detect highly redshifted hydrogen from the epoch of reionization and/or to perform wide-field surveys for time-domain studies of the radio sky. We experimentally show the direct-imaging correlator architecture to be a viable solution for correlation and beamforming.

  3. Three-Dimensional Route Planning for a Cruise Missile for Minimal Detection by Observer

    DTIC Science & Technology

    1989-06-01

    detect the enemy’s weakest avenues of approach are needed. Such systems could also be used to identify our own deficiencies and allow for...vector-k (oval (line-segment-direction-vector (oval line-i))))) ( Tk2 (vector-k (eval (line-segment-direction-voctor (oval line-2))))) (Tval ’nil...zerop Tkl)) (not (zerop Tk2 ))) (setf Tval (/ Tkl Tk2 ))) (t (return-from parallel-lines ’nil))) (cond ((and (equal Til (* Tval Ti2)) (equal Tjl (* Tval

  4. Induction of infectious petunia vein clearing (pararetro) virus from endogenous provirus in petunia

    PubMed Central

    Richert-Pöggeler, Katja R.; Noreen, Faiza; Schwarzacher, Trude; Harper, Glyn; Hohn, Thomas

    2003-01-01

    Infection by an endogenous pararetrovirus using forms of both episomal and chromosomal origin has been demonstrated and characterized, together with evidence that petunia vein clearing virus (PVCV) is a constituent of the Petunia hybrida genome. Our findings allow comparative and direct analysis of horizontally and vertically transmitted virus forms and demonstrate their infectivity using biolistic transformation of a provirus-free petunia species. Some integrants within the genome of P.hybrida are arranged in tandem, allowing direct release of virus by transcription. In addition to known inducers of endogenous pararetroviruses, such as genome hybridization, tissue culture and abiotic stresses, we observed activation of PVCV after wounding. Our data also support the hypothesis that the host plant uses DNA methylation to control the endogenous pararetrovirus. PMID:12970195

  5. Electrochemistry of metalloproteins: protein film electrochemistry for the study of E. coli [NiFe]-hydrogenase-1.

    PubMed

    Evans, Rhiannon M; Armstrong, Fraser A

    2014-01-01

    Protein film electrochemistry is a technique which allows the direct control of redox-active enzymes, providing particularly detailed information on their catalytic properties. The enzyme is deposited onto a working electrode tip, and through control of the applied potential the enzyme activity is monitored as electrical current, allowing for direct study of inherent activity as electrons are transferred to and from the enzyme redox center(s). No mediators are used. Because the only enzyme present in the experiment is bound at the electrode surface, gaseous and liquid phase inhibitors can be introduced and removed whilst the enzyme remains in situ. Potential control means that kinetics and thermodynamics are explored simultaneously; the kinetics of a reaction can be studied as a function of potential. Steady-state catalytic rates are observed directly as current (for a given potential) and non-steady-state rates (such as interconversions between different forms of the enzyme) are observed from the change in current with time. The more active the enzyme, the higher the current and the better the signal-to-noise. In this chapter we outline the practical aspects of PFE for studying electroactive enzymes, using the Escherichia coli [NiFe]-hydrogenase 1 (Hyd-1) as an example.

  6. Stellar Properties of Embedded Protostars: Progress and Prospects

    NASA Technical Reports Server (NTRS)

    Greene, Thomas

    2006-01-01

    Until now, high extinctions have prevented direct observation of the central objects of self-embedded, accreting protostars. However, sensitive high dispersion spectrographs on large aperture telescopes have allowed us to begin studying the stellar astrophysical properties of dozens of embedded low mass protostars in the nearest regions of star formation. These high dispersion spectra allow, for the first time, direct measurements of their stellar effective temperatures, surface gravities, rotation velocities, radial velocities (and spectroscopic binarity), mass accretion properties, and mass outflow indicators. Comparisons of the stellar properties with evolutionary models also allow us to estimate masses and constrain ages. We find that these objects have masses similar to those of older, more evolved T Tauri stars, but protostars have higher mean rotation velocities and angular momenta. Most protostars indicate high mass accretion or outflow, but some in Taurus-Auriga appear to be relatively quiescent. These new results are testing, expanding, and refining the standard star formation paradigm, and we explore how to expand this work further.

  7. Converting Differential Photometry Results to the Standard System using Transform Generator and Transform Applier (Abstract)

    NASA Astrophysics Data System (ADS)

    Ciocca, M.

    2016-12-01

    (Abstract only) Since Fall of 2014, AAVSO made available two very useful software tools: transform generator (tg) and transform applier (ta). tg, authored by Gordon Myers (gordonmyers@hotmail.com), is a program, running under python that allows the user to obtain the transformation coefficients of their imaging train. ta, authored by George Silvis, allows users to apply the transformation coefficients obtained previously to their photometric observation. The data so processed become then directly comparable to those of other observers. I will show how to obtain transform coefficient using two Standard Field (M 67 and NGC7790), how consistent the results are and as an application, I will present transformed data for two AAVSO Target stars, AE UMA and RR CET.

  8. Using Stress Balls to Focus the Attention of Sixth-Grade Learners

    ERIC Educational Resources Information Center

    Stalvey, Sheryl; Brasell, Heather

    2006-01-01

    This pilot study investigated the effects of allowing sixth-grade students in a rural south Georgia school to use stress balls during direct instruction and independent practice. Data from learning style inventories, surveys, journals, teacher observations, and formal assessments were collected for 29 sixth-grade students in a language arts class.…

  9. Kinematic Measures of Imitation Fidelity in Primary School Children

    ERIC Educational Resources Information Center

    Williams, Justin H. G.; Casey, Jackie M.; Braadbaart, Lieke; Culmer, Peter R.; Mon-Williams, Mark

    2014-01-01

    We sought to develop a method for measuring imitation accuracy objectively in primary school children. Children imitated a model drawing shapes on the same computer-tablet interface they saw used in video clips, allowing kinematics of model and observers' actions to be directly compared. Imitation accuracy was reported as a correlation reflecting…

  10. Evolution of the Anatomical Theatre in Padova

    ERIC Educational Resources Information Center

    Macchi, Veronica; Porzionato, Andrea; Stecco, Carla; Caro, Raffaele

    2014-01-01

    The anatomical theatre played a pivotal role in the evolution of medical education, allowing students to directly observe and participate in the process of dissection. Due to the increase of training programs in clinical anatomy, the Institute of Human Anatomy at the University of Padova has renovated its dissecting room. The main guidelines in…

  11. Clustered regularly interspaced short palindromic repeats (CRISPRs) for the genotyping of bacterial pathogens.

    PubMed

    Grissa, Ibtissem; Vergnaud, Gilles; Pourcel, Christine

    2009-01-01

    Clustered regularly interspaced short palindromic repeats (CRISPRs) are DNA sequences composed of a succession of repeats (23- to 47-bp long) separated by unique sequences called spacers. Polymorphism can be observed in different strains of a species and may be used for genotyping. We describe protocols and bioinformatics tools that allow the identification of CRISPRs from sequenced genomes, their comparison, and their component determination (the direct repeats and the spacers). A schematic representation of the spacer organization can be produced, allowing an easy comparison between strains.

  12. Multi-cultural Wikipedia mining of geopolitics interactions leveraging reduced Google matrix analysis

    NASA Astrophysics Data System (ADS)

    Frahm, Klaus M.; El Zant, Samer; Jaffrès-Runser, Katia; Shepelyansky, Dima L.

    2017-09-01

    Geopolitics focuses on political power in relation to geographic space. Interactions among world countries have been widely studied at various scales, observing economic exchanges, world history or international politics among others. This work exhibits the potential of Wikipedia mining for such studies. Indeed, Wikipedia stores valuable fine-grained dependencies among countries by linking webpages together for diverse types of interactions (not only related to economical, political or historical facts). We mine herein the Wikipedia networks of several language editions using the recently proposed method of reduced Google matrix analysis. This approach allows to establish direct and hidden links between a subset of nodes that belong to a much larger directed network. Our study concentrates on 40 major countries chosen worldwide. Our aim is to offer a multicultural perspective on their interactions by comparing networks extracted from five different Wikipedia language editions, emphasizing English, Russian and Arabic ones. We demonstrate that this approach allows to recover meaningful direct and hidden links among the 40 countries of interest.

  13. Cellular and Molecular Mechanisms of Action of Transcranial Direct Current Stimulation: Evidence from In Vitro and In Vivo Models

    PubMed Central

    Pelletier, Simon J.

    2015-01-01

    Transcranial direct current stimulation is a noninvasive technique that has been experimentally tested for a number of psychiatric and neurological conditions. Preliminary observations suggest that this approach can indeed influence a number of cellular and molecular pathways that may be disease relevant. However, the mechanisms of action underlying its beneficial effects are largely unknown and need to be better understood to allow this therapy to be used optimally. In this review, we summarize the physiological responses observed in vitro and in vivo, with a particular emphasis on cellular and molecular cascades associated with inflammation, angiogenesis, neurogenesis, and neuroplasticity recruited by direct current stimulation, a topic that has been largely neglected in the literature. A better understanding of the neural responses to transcranial direct current stimulation is critical if this therapy is to be used in large-scale clinical trials with a view of being routinely offered to patients suffering from various conditions affecting the central nervous system. PMID:25522391

  14. Simulated Milky Way analogues: implications for dark matter direct searches

    NASA Astrophysics Data System (ADS)

    Bozorgnia, Nassim; Calore, Francesca; Schaller, Matthieu; Lovell, Mark; Bertone, Gianfranco; Frenk, Carlos S.; Crain, Robert A.; Navarro, Julio F.; Schaye, Joop; Theuns, Tom

    2016-05-01

    We study the implications of galaxy formation on dark matter direct detection using high resolution hydrodynamic simulations of Milky Way-like galaxies simulated within the EAGLE and APOSTLE projects. We identify Milky Way analogues that satisfy observational constraints on the Milky Way rotation curve and total stellar mass. We then extract the dark matter density and velocity distribution in the Solar neighbourhood for this set of Milky Way analogues, and use them to analyse the results of current direct detection experiments. For most Milky Way analogues, the event rates in direct detection experiments obtained from the best fit Maxwellian distribution (with peak speed of 223-289 km/s) are similar to those obtained directly from the simulations. As a consequence, the allowed regions and exclusion limits set by direct detection experiments in the dark matter mass and spin-independent cross section plane shift by a few GeV compared to the Standard Halo Model, at low dark matter masses. For each dark matter mass, the halo-to-halo variation of the local dark matter density results in an overall shift of the allowed regions and exclusion limits for the cross section. However, the compatibility of the possible hints for a dark matter signal from DAMA and CDMS-Si and null results from LUX and SuperCDMS is not improved.

  15. Observations from the High Resolution Imaging Science Experiment (HiRISE): Martian dust devils in Gusev and Russell craters

    NASA Astrophysics Data System (ADS)

    Verba, Circe A.; Geissler, Paul E.; Titus, Timothy N.; Waller, Devin

    2010-09-01

    Two areas targeted for repeated imaging by detailed High Resolution Imaging Science Experiment (HiRISE) observations allow us to examine morphological differences and monitor seasonal variations of Martian dust devil tracks at two quite different locations. Russell crater (53.3°S, 12.9°E) is regularly imaged to study seasonal processes including deposition and sublimation of CO2 frost. Gusev crater (14.6°S, 175.4°E) has been frequently imaged in support of the Mars Exploration Rover mission. Gusev crater provides the first opportunity to compare “ground truth” orbital observations of dust devil tracks to surface observations of active dust plumes. Orbital observations show that dust devil tracks are rare, forming at a rate <1/110 that of the occurrence of active dust plumes estimated from Spirit's surface observations. Furthermore, the tracks observed from orbit are wider than typical plume diameters observed by Spirit. We conclude that the tracks in Gusev are primarily formed by rare, large dust devils. Smaller dust devils fail to leave tracks that are visible from orbit, perhaps because of limited surface excavation depths. Russell crater displays more frequent, smaller sinuous tracks than Gusev. This may be due to the thin dust cover in Russell, allowing smaller dust devils to penetrate through the bright dust layer and leave conspicuous tracks. The start of the dust devil season and peak activity are delayed in Russell in comparison to Gusev, likely because of its more southerly location. Dust devils in both sites travel in directions consistent with general circulation model (GCM)-predicted winds, confirming a laboratory-derived approach to determining dust devil travel directions based on track morphology.

  16. NGC 2024: Far-infrared and radio molecular observations

    NASA Technical Reports Server (NTRS)

    Thronson, H. A., Jr.; Lada, C. J.; Schwartz, P. R.; Smith, H. A.; Smith, J.; Glaccum, W.; Harper, D. A.; Loewenstein, R. F.

    1984-01-01

    Far infrared continuum and millimeter wave molecular observations are presented for the infrared and radio source NGC 2024. The measurements are obtained at relatively high angular resolution, enabling a description of the source energetics and mass distribution in greater detail than previously reported. The object appears to be dominated by a dense ridge of material, extended in the north/south direction and centered on the dark lane that is seen in visual photographs. Maps of the source using the high density molecules CS and HCN confirm this picture and allow a description of the core structure and molecular abundances. The radio molecular and infrared observations support the idea that an important exciting star in NGC 2024 has yet to be identified and is centered on the dense ridge about 1' south of the bright mid infrared source IRS 2. The data presented here allows a presentation of a model for the source.

  17. Automated single cell microbioreactor for monitoring intracellular dynamics and cell growth in free solution†

    PubMed Central

    Johnson-Chavarria, Eric M.; Agrawal, Utsav; Tanyeri, Melikhan; Kuhlman, Thomas E.

    2014-01-01

    We report an automated microfluidic-based platform for single cell analysis that allows for cell culture in free solution with the ability to control the cell growth environment. Using this approach, cells are confined by the sole action of gentle fluid flow, thereby enabling non-perturbative analysis of cell growth away from solid boundaries. In addition, the single cell microbioreactor allows for precise and time-dependent control over cell culture media, with the combined ability to observe the dynamics of non-adherent cells over long time scales. As a proof-of-principle demonstration, we used the platform to observe dynamic cell growth, gene expression, and intracellular diffusion of repressor proteins while precisely tuning the cell growth environment. Overall, this microfluidic approach enables the direct observation of cellular dynamics with exquisite control over environmental conditions, which will be useful for quantifying the behaviour of single cells in well-defined media. PMID:24836754

  18. Staging a Reflective Capstone Course to Transition PharmD Graduates to Professional Life

    PubMed Central

    Hobson, Eric H.; Spinelli, Alisa J.

    2015-01-01

    Objective. To develop and implement a capstone course that would allow students to reflect on their development as a professional, assess and share their achievement of the college’s outcomes, complete a professional portfolio, establish a continuing professional development plan, and prepare to enter the pharmacy profession. Design. Students were required to complete a hybrid course built around 4 online and inclass projects during the final semester of the curriculum. Assessment. Faculty used direct measures of learning, such as reading student portfolios and program outcome reflections, evaluating professional development plans, and directly observing each student in a video presentation. All projects were evaluated using standardized rubrics. Since 2012, all graduating students met the course’s minimum performance requirements. Conclusion. The course provided an opportunity for student-based summative evaluation, direct observation of student skills, and documentation of outcome completion as a means of evaluating readiness to enter the profession. PMID:25741030

  19. Simulation of anisotropic fracture behaviour of polycrystalline round blank tungsten using cohesive zone model

    NASA Astrophysics Data System (ADS)

    Mahler, Michael; Gaganidze, Ermile; Aktaa, Jarir

    2018-04-01

    The experimental observation of anisotropic fracture behaviour of round blank polycrystalline tungsten was simulated using finite element (FE) method in combination with cohesive zone model. Experiments in the past had shown that due to the anisotropic microstructure the fracture toughness varies by factor of about two for different orientations. The reason is the crack propagation direction, which is - in some orientations - not the typical crack propagation direction for mode I fracture. In some directions the crack is not growing perpendicular to the crack opening tensile load. Nevertheless, in the present paper, the microstructure is modelled by FE mesh including cohesive zone elements which mimic grain boundaries (GB). This is based on the assumption that GB's are the weakest links in the structure. The use of the correct parameters to describe the fracture process allows the description of the observed experimental orientation dependent fracture toughness.

  20. Remote sensing of reconnection via ARTEMIS dual-spacecraft observations

    NASA Astrophysics Data System (ADS)

    Kiehas, Stefan; Angelopoulos, Vassilis; Runov, Andrei; Li, Shan-Shan

    2013-04-01

    Each month the two ARTEMIS probes spend about four days in the Earth's magnetotail near lunar orbit. Due to the near-equatorial orbit, the probes spend a considerable time near and inside the plasma sheet. This allows us to investigate large-scale effects of reconnection, such as flux ropes and high-speed flows, utilizing dual-probe observations on a regular basis. On August 31, 2012 around 03:00 UT, the ARTEMIS probes were separated by only 350 km in X_GSW and 0.6 (1) RE in Y_GSW (Z_GSW), where GSW denotes the Geocentric Solar Wind coordinate system, which x-axis is antiparallel to the solar wind flow direction. The two probes observe several TCRs and flux ropes. The inter-spacecraft separation allows us to determine the size of these structures to be not more than 6 RE in z. Counterstreaming beams observed by both probes indicate the simultaneous activity of two X-lines, earthward and tailward of the probes, respectively.

  1. The direct connections of the C2 dorsal ganglion in the brain stem of the squirrel monkey: a preliminary investigation *

    PubMed Central

    Fitz-Ritson, Don E.

    1979-01-01

    The purpose of this investigation was to observe the possible anatomical connections of C2 dorsal root with brain stem nuclei. Labelled amino acids (leucine, glycine, proline), were injected into the dorsal root of C2 of a squirrel monkey. The animal was allowed to survive for 20 hrs. and after, sections of the spinal cord and brain stem were subjected to autoradiographic methods. Direct connections were observed in Lamina II, VII, VIII of the spinal cord; the hypoglossal nucleus, medial vestibular nucleus, lateral cuneatus nucleus and lateral parvocellular reticular formation. Possible anatomical and physiological correlates are explored in relation to the importance of the upper cervical area and its control mechanisms.

  2. Coordinated CRISM and Opportunity Observations to Characterize the Mineralogy and Geologic History of Meridiani Planum Outcrops

    NASA Astrophysics Data System (ADS)

    Arvidson, R. E.

    2011-12-01

    The Opportunity Mars Exploration Rover has traversed over 30 km across Meridiani Planum since January 2004, acquiring numerous remote sensing and in-situ measurements of rocks and soils at dozens of locations. Over the past year Mars Reconnaissance Orbiter CRISM (0.362 to 3.92 micrometer imaging spectrometer) observations have been used to directly support planning of Opportunity traverses and locations for detailed remote sensing and in-situ measurements. As part of these coordinated observations CRISM's gimbaled optics have been used to spatially oversample acquisition of image data in the along-track direction (ATO or along track oversampled observations). This new acquisition mode allows sharpening the spatial detail from the normal ~18 m/pixel observations to values as small as ~6 m/pixel, with due formal consideration of the decrease in S/N with decreasing pixel sizes for retrieval of the 544 band spectra for each pixel. CRISM ATO observations show that mono-hydrated sulfates, most likely kieserite, outcrop on the walls of Victoria crater and the southeastern rim of Santa Maria crater. Unfortunately, the Victoria identifications are on the opposite side of the crater relative to where Opportunity made measurements of Victoria wall rocks. On the other hand, Opportunity was directed to Santa Maria's southeastern rim based on CRISM spectral reflectance data, spending the last solar conjunction period acquiring long-duration in-situ measurements of outcrop that likely carries the mono-hydrated sulfate signature. Additional ATO data collected over the relatively fresh, 2.3 km wide Ada crater located in southeastern Meridiani Planum show a similar mono-hydrated sulfate signature, implying that these deposits are widespread. Further, ATO observations allow detailed mapping of extensive hydrated sulfates in Botany Bay immediately to the south of Cape York, a rim segment of the largely buried, Noachian age Endeavour crater. Opportunity will cross these hydrated bedrock exposures on the way to Cape York outcrops. We will report on results from Opportunity's measurements on Victoria, Santa Maria, and Ada craters, together with measurements within Botany Bay, focusing on the synergistic use of Opportunity and CRISM observations to understand the mineralogy and geologic history of Meridiani Planum.

  3. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lopez, Anthony

    Presentation at ASHRAE about the spatial and temporal variability of gridded TMYs, discussing advanced GIS and Web services that allow for direct access to data, surface-based observations for thousands of stations, climate reanalysis data, and products derived from satellite data; new developments in NREL's solar databases based on both observed data and satellite-derived gridded data, status of TMY3 weather files, and NREL's plans for the next-generation TMY weather files; and also covers what is new and different in the Climatic Design Conditions Table in the 2013 ASHRAE Handbook of Fundamentals.

  4. Ion kinetic scale in the solar wind observed.

    PubMed

    Śafránková, Jana; Němeček, Zdeněk; Přech, Lubomír; Zastenker, Georgy N

    2013-01-11

    This Letter shows the first results from the solar wind monitor onboard the Spektr-R spacecraft which measures plasma moments with a time resolution of 31 ms. This high-time resolution allows us to make direct observations of solar wind turbulence below ion kinetic length scales. We present examples of the frequency spectra of the density, velocity, and thermal velocity. Our study reveals that although these parameters exhibit the same behavior at the magnetohydrodynamic scale, their spectra are remarkably different at the kinetic scale.

  5. Cross section TEM characterization of high-energy-Xe-irradiated U-Mo

    DOE PAGES

    Ye, B.; Jamison, L.; Miao, Y.; ...

    2017-03-09

    U-Mo alloys irradiated with 84 MeV Xe ions to various doses were characterized with transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) techniques. The TEM thin foils were prepared perpendicular to the irradiated surface to allow a direct observation of the entire region modified by ions. Furthermore, depth-selective microstructural information was revealed. Varied irradiation-induced phenomena such as gas bubble formation, phase reversal, and recrystallization were observed at different ion penetration depths in U-Mo.

  6. Verbal Rehearsal and Short-Term Memory in Reading-disabled Children

    ERIC Educational Resources Information Center

    Torgesen, Joseph; Goldman, Tina

    1977-01-01

    To determine whether the frequently found short-term memory deficits in poor readers reflect a lack of ability or inclination to use efficient task strategies, the performances of second-grade good and poor readers were compared on a task which allowed direct observation of the use of verbal rehearsal as a mnemonic strategy. (Author/JMB)

  7. Hydraulic redistribution of soil water by neotropical savanna trees.

    Treesearch

    Fabian G. Scholz; Sandra J. Bucci; Guillermo Goldstein; et al.

    2002-01-01

    The magnitude and direction of water transport by the roots of eight dominant Brazilian savanna (Cerrado) allowed bidirectional measurements of sap flow. The patterns of sap flow observed during the dry season in species with dimorphic roots systems were consistent with the occurrence of hydraulic redistribution of soil water, the movement of water from moist to drier...

  8. A Proposal for Testing Local Realism Without Using Assumptions Related to Hidden Variable States

    NASA Technical Reports Server (NTRS)

    Ryff, Luiz Carlos

    1996-01-01

    A feasible experiment is discussed which allows us to prove a Bell's theorem for two particles without using an inequality. The experiment could be used to test local realism against quantum mechanics without the introduction of additional assumptions related to hidden variables states. Only assumptions based on direct experimental observation are needed.

  9. An Interactive Computer Model for Improved Student Understanding of Random Particle Motion and Osmosis

    ERIC Educational Resources Information Center

    Kottonau, Johannes

    2011-01-01

    Effectively teaching the concepts of osmosis to college-level students is a major obstacle in biological education. Therefore, a novel computer model is presented that allows students to observe the random nature of particle motion simultaneously with the seemingly directed net flow of water across a semipermeable membrane during osmotic…

  10. Rubber Bands as Model Polymers in Couette Flow

    ERIC Educational Resources Information Center

    Dunstan, Dave E.

    2008-01-01

    We present a simple device for demonstrating the essential aspects of polymers in flow in the classroom. Rubber bands are used as a macroscopic model of polymers to allow direct visual observation of the flow-induced changes in orientation and conformation. A transparent Perspex Couette cell, constructed from two sections of a tube, is used to…

  11. Direct measurement of light waves.

    PubMed

    Goulielmakis, E; Uiberacker, M; Kienberger, R; Baltuska, A; Yakovlev, V; Scrinzi, A; Westerwalbesloh, Th; Kleineberg, U; Heinzmann, U; Drescher, M; Krausz, F

    2004-08-27

    The electromagnetic field of visible light performs approximately 10(15) oscillations per second. Although many instruments are sensitive to the amplitude and frequency (or wavelength) of these oscillations, they cannot access the light field itself. We directly observed how the field built up and disappeared in a short, few-cycle pulse of visible laser light by probing the variation of the field strength with a 250-attosecond electron burst. Our apparatus allows complete characterization of few-cycle waves of visible, ultraviolet, and/or infrared light, thereby providing the possibility for controlled and reproducible synthesis of ultrabroadband light waveforms.

  12. Brain network dynamics characterization in epileptic seizures. Joint directed graph and pairwise synchronization measures

    NASA Astrophysics Data System (ADS)

    Rodrigues, A. C.; Machado, B. S.; Florence, G.; Hamad, A. P.; Sakamoto, A. C.; Fujita, A.; Baccalá, L. A.; Amaro, E.; Sameshima, K.

    2014-12-01

    Here we propose and evaluate a new approach to analyse multichannel mesial temporal lobe epilepsy EEG data from eight patients through complex network and synchronization theories. The method employs a Granger causality test to infer the directed connectivity graphs and a wavelet transform based phase synchronization measure whose characteristics allow studying dynamical transitions during epileptic seizures. We present a new combined graph measure that quantifies the level of network hub formation, called network hub out-degree, which closely reflects the level of synchronization observed during the ictus.

  13. Seismic detection and analysis of icequakes at Columbia Glacier, Alaska

    USGS Publications Warehouse

    O'Neel, Shad; Marshall, Hans P.; McNamara, Daniel E.; Pfeffer, William Tad

    2007-01-01

    Contributions to sea level rise from rapidly retreating marine-terminating glaciers are large and increasing. Strong increases in iceberg calving occur during retreat, which allows mass transfer to the ocean at a much higher rate than possible through surface melt alone. To study this process, we deployed an 11-sensor passive seismic network at Columbia Glacier, Alaska, during 2004–2005. We show that calving events generate narrow-band seismic signals, allowing frequency domain detections. Detection parameters were determined using direct observations of calving and validated using three statistical methods and hypocenter locations. The 1–3 Hz detections provide a good measure of the temporal distribution and size of calving events. Possible source mechanisms for the unique waveforms are discussed, and we analyze potential forcings for the observed seismicity.

  14. Stellar CME candidates: towards a stellar CME-flare relation

    NASA Astrophysics Data System (ADS)

    Paraskevi Moschou, Sofia; Drake, Jeremy J.; Cohen, Ofer; Alvarado-Gomez, Julian D.; Garraffo, Cecilia

    2018-06-01

    For decades the Sun has been the only star that allowed for direct CME observations. Recently, with the discovery of multiple extrasolar systems, it has become imperative that the role of stellar CMEs be assessed in the context of exoplanetary habitability. Solar CMEs and flares show a higher association with increasing flaring energy, with strong flares corresponding to large and fast CMEs. As argued in earlier studies, extrasolar environments around active stars are potentially dominated by CMEs, as a result of their extreme flaring activity. This has strong implications for the energy budget of the system and the atmospheric erosion of orbiting planets.Nevertheless, with current instrumentation we are unable to directly observe CMEs in even the closest stars, and thus we have to look for indirect techniques and observational evidence and signatures for the eruption of stellar CMEs. There are three major observational techniques for tracing CME signatures in other stellar systems, namely measuring Type II radio bursts, Doppler shifts in UV/optical lines or transient absorption in the X-ray spectrum. We present observations of the most probable stellar CME candidates captured so far and examine the different observational techniques used together with their levels of uncertainty. Assuming that they were CMEs, we try to asses their kinematic and energetic characteristics and place them in an extension of the well-established solar CME-flare energy scaling law. We finish by discussing future observations for direct measurements.

  15. Low frequency gyro-synchrotron radio noise from the earth's outer radiation belt

    NASA Technical Reports Server (NTRS)

    Frankel, M. S.

    1973-01-01

    The problem of detecting cyclotron and synchrotron noise from superthermal electrons is analyzed for the frequency range 30 kHz 300 kHz. Due to the earth's ionosphere, ground based observation of this noise is improbable. Therefore, the calculations are made for an observer in the interplanetary medium. In particular, the location is chosen in the geomagnetic equatorial plane at a geocentric distance of 32 earth radii. This position of the observer allows the theoretical results to be compared directly with data obtained from the radio astronomy experiment aboard the IMP-6 spacecraft.

  16. An Unroofing Method to Observe the Cytoskeleton Directly at Molecular Resolution Using Atomic Force Microscopy

    PubMed Central

    Usukura, Eiji; Narita, Akihiro; Yagi, Akira; Ito, Shuichi; Usukura, Jiro

    2016-01-01

    An improved unroofing method enabled the cantilever of an atomic force microscope (AFM) to reach directly into a cell to visualize the intracellular cytoskeletal actin filaments, microtubules, clathrin coats, and caveolae in phosphate-buffered saline (PBS) at a higher resolution than conventional electron microscopy. All of the actin filaments clearly exhibited a short periodicity of approximately 5–6 nm, which was derived from globular actins linked to each other to form filaments, as well as a long helical periodicity. The polarity of the actin filaments appeared to be determined by the shape of the periodic striations. Microtubules were identified based on their thickness. Clathrin coats and caveolae were observed on the cytoplasmic surface of cell membranes. The area containing clathrin molecules and their terminal domains was directly visualized. Characteristic ridge structures located at the surface of the caveolae were observed at high resolution, similar to those observed with electron microscopy (EM). Overall, unroofing allowed intracellular AFM imaging in a liquid environment with a level of quality equivalent or superior to that of EM. Thus, AFMs are anticipated to provide cutting-edge findings in cell biology and histology. PMID:27273367

  17. THE ROLL-OVER OF HELIOSPHERIC NEUTRAL HYDROGEN BELOW 100 eV: OBSERVATIONS AND IMPLICATIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Galli, A.; Wurz, P.; Schwadron, N. A.

    2016-04-20

    We present an improved analysis of the energy spectrum of energetic neutral hydrogen from the heliosheath observed with the IBEX -Lo sensor on the Interstellar Boundary EXplorer from the years 2009 to 2012. This analysis allows us to study the lowest energies between 10 and 100 eV although various background sources are more intense than the targeted signal over broad areas of the sky. The results improve our knowledge of the interaction region between our heliosphere and the interstellar plasma because these neutral atoms are direct messengers from the low-energy plasma in the heliosheath. We find a roll-over of themore » energy spectrum below 100 eV, which has major implications for the pressure balance of the plasma in the inner heliosheath. The results can also be compared directly with in situ observations of the Voyager 1 and 2 spacecraft.« less

  18. In vivo imaging of leukocyte recruitment to glomeruli in mice using intravital microscopy.

    PubMed

    Kitching, A Richard; Kuligowski, Michael P; Hickey, Michael J

    2009-01-01

    Leukocytes mediate some forms of glomerulonephritis, particularly severe proliferative and crescentic forms. The renal glomerulus is one of the few sites within the microvasculature in which leukocyte recruitment occurs in capillaries. However, due to the difficulty of directly visualising the glomerulus, the mechanisms of leukocyte recruitment to glomerular capillaries are poorly understood. To overcome this, a murine kidney can be rendered hydronephrotic, by ligating one ureter, and allowing the mouse to rest for 12 weeks. This allows the visualisation of the glomerular microvasculature during inflammatory responses. In inflammation, in this example induced by anti-glomerular basement membrane (GBM) antibody, leukocytes can be observed undergoing adhesion in glomerular capillaries using intravital microscopy. Leukocyte adhesion can be quantitated using this approach. An observation protocol involving few, limited periods of epifluorescence avoids phototoxicity-induced leukocyte recruitment. The process of hydronephrosis does not alter the ability of anti-GBM-antibody to induce a glomerular inflammatory response. This approach allows detailed investigation of the mechanisms of leukocyte recruitment within glomeruli.

  19. Observations of field-aligned currents, particles, and plasma drift in the polar cusps near solstice

    NASA Technical Reports Server (NTRS)

    Bythrow, P. F.; Potemra, T. A.; Hoffman, R. A.

    1982-01-01

    Magnetic perturbations observed by the TRIAD magnetometer within two hours of an AE-C spacecraft pass provide field-aligned current data, from the same local time in the northern hemisphere, for a study of the polar cusp. The AE-C spinning mode has allowed the use of the Z-axis magnetometer for Birkeland current observations, in conjunction with particle and drift measurements. The average B(z) were found to be 1.9 nT and -1.1 nT during the first two hourly intervals on January 15, 1977. Measurements from the low energy electron experiment revealed intense fluxes of soft, cusp-like 100 eV Maxwellian electrons throughout the prenoon polar cap. The upward directed current can be identified as the dominant cusp current appropriate for B(y) values lower than zero, while the downward directed current, which has the appropriate sign of a dayside region 1 current, is observed to lie entirely within a westerly, antisunward-convecting plasma.

  20. Satellite observations of type III solar radio bursts at low frequencies

    NASA Technical Reports Server (NTRS)

    Fainberg, J.; Stone, R. G.

    1974-01-01

    Type III solar radio bursts have been observed from 10 MHz to 10 kHz by satellite experiments above the terrestrial plasmasphere. Solar radio emission in this frequency range results from excitation of the interplanetary plasma by energetic particles propagating outward along open field lines over distances from 5 earth radii to at least 1 AU from the sun. This review summarizes the morphology, characteristics, and analysis of individual as well as storms of bursts. Substantial evidence is available to show that the radio emission is observed at the second harmonic instead of the fundamental of the plasma frequency. This brings the density scale derived by radio observations into better agreement with direct solar wind density measurements at 1 AU and relaxes the requirement for type III propagation along large density-enhanced regions. This density scale with the measured direction of arrival of the radio burst allows the trajectory of the exciter path to be determined from 10 earth radii to 1 AU.

  1. Magnetospheric Multiscale Observations of Magnetic Reconnection Associated with Kelvin-Helmholtz Waves

    NASA Technical Reports Server (NTRS)

    Eriksson, S.; Lavraud, B.; Wilder, F. D.; Stawarz, J. E.; Giles, B. L.; Burch, J. L.; Baumjohann, W.; Ergun, R. E.; Lindqvist, P.-A.; Magnes, W.; hide

    2016-01-01

    The four Magnetospheric Multiscale (MMS) spacecraft recorded the first direct evidence of reconnection exhausts associated with Kelvln-Helmholtz (KH) waves at the duskside magnetopause on 8 September 2015 which allows for local mass and energy transport across the flank magnetopause. Pressure anisotropy-weighted Walen analyses confirmed in-plane exhausts across 22 of 42 KH-related trailing magnetopause current sheets (CSs). Twenty-one jets were observed by all spacecraft, with small variations in ion velocity, along the same sunward or antisunward direction with nearly equal probability. One exhaust was only observed by the MMS-1,2 pair, while MMS-3,4 traversed a narrow CS (1.5 ion inertial length) in the vicinity of an electron diffusion region. The exhausts were locally 2-D planar in nature as MMS-1, 2 observed almost identical signatures separated along the guide-field. Asymmetric magnetic and electric Hall fields are reported in agreement with a strong guide-field and a weak plasma density asymmetry across the magnetopause CS.

  2. Crystal accumulation in the Hanford Waste Treatment Plant high level waste melter: Summary of 2017 experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fox, K.; Fowley, M.

    A full-scale, transparent mock-up of the Hanford Tank Waste Treatment and Immobilization Project High Level Waste glass melter riser and pour spout has been constructed to allow for testing with visual feedback of particle settling, accumulation, and resuspension when operating with a controlled fraction of crystals in the glass melt. Room temperature operation with silicone oil and magnetite particles simulating molten glass and spinel crystals, respectively, allows for direct observation of flow patterns and settling patterns. The fluid and particle mixture is recycled within the system for each test.

  3. Assessing distractors and teamwork during surgery: developing an event-based method for direct observation.

    PubMed

    Seelandt, Julia C; Tschan, Franziska; Keller, Sandra; Beldi, Guido; Jenni, Nadja; Kurmann, Anita; Candinas, Daniel; Semmer, Norbert K

    2014-11-01

    To develop a behavioural observation method to simultaneously assess distractors and communication/teamwork during surgical procedures through direct, on-site observations; to establish the reliability of the method for long (>3 h) procedures. Observational categories for an event-based coding system were developed based on expert interviews, observations and a literature review. Using Cohen's κ and the intraclass correlation coefficient, interobserver agreement was assessed for 29 procedures. Agreement was calculated for the entire surgery, and for the 1st hour. In addition, interobserver agreement was assessed between two tired observers and between a tired and a non-tired observer after 3 h of surgery. The observational system has five codes for distractors (door openings, noise distractors, technical distractors, side conversations and interruptions), eight codes for communication/teamwork (case-relevant communication, teaching, leadership, problem solving, case-irrelevant communication, laughter, tension and communication with external visitors) and five contextual codes (incision, last stitch, personnel changes in the sterile team, location changes around the table and incidents). Based on 5-min intervals, Cohen's κ was good to excellent for distractors (0.74-0.98) and for communication/teamwork (0.70-1). Based on frequency counts, intraclass correlation coefficient was excellent for distractors (0.86-0.99) and good to excellent for communication/teamwork (0.45-0.99). After 3 h of surgery, Cohen's κ was 0.78-0.93 for distractors, and 0.79-1 for communication/teamwork. The observational method developed allows a single observer to simultaneously assess distractors and communication/teamwork. Even for long procedures, high interobserver agreement can be achieved. Data collected with this method allow for investigating separate or combined effects of distractions and communication/teamwork on surgical performance and patient outcomes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  4. Simulated Milky Way analogues: implications for dark matter direct searches

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bozorgnia, Nassim; Calore, Francesca; Lovell, Mark

    2016-05-01

    We study the implications of galaxy formation on dark matter direct detection using high resolution hydrodynamic simulations of Milky Way-like galaxies simulated within the EAGLE and APOSTLE projects. We identify Milky Way analogues that satisfy observational constraints on the Milky Way rotation curve and total stellar mass. We then extract the dark matter density and velocity distribution in the Solar neighbourhood for this set of Milky Way analogues, and use them to analyse the results of current direct detection experiments. For most Milky Way analogues, the event rates in direct detection experiments obtained from the best fit Maxwellian distribution (withmore » peak speed of 223–289 km/s) are similar to those obtained directly from the simulations. As a consequence, the allowed regions and exclusion limits set by direct detection experiments in the dark matter mass and spin-independent cross section plane shift by a few GeV compared to the Standard Halo Model, at low dark matter masses. For each dark matter mass, the halo-to-halo variation of the local dark matter density results in an overall shift of the allowed regions and exclusion limits for the cross section. However, the compatibility of the possible hints for a dark matter signal from DAMA and CDMS-Si and null results from LUX and SuperCDMS is not improved.« less

  5. Confocal imaging to quantify passive transport across biomimetic lipid membranes.

    PubMed

    Li, Su; Hu, Peichi; Malmstadt, Noah

    2010-09-15

    The ability of a molecule to pass through the plasma membrane without the aid of any active cellular mechanisms is central to that molecule's pharmaceutical characteristics. Passive transport has been understood in the context of Overton's rule, which states that more lipophilic molecules cross membrane lipid bilayers more readily. Existing techniques for measuring passive transport lack reproducibility and are hampered by the presence of an unstirred layer (USL) that dominates transport across the bilayer. This report describes assays based on spinning-disk confocal microscopy (SDCM) of giant unilamellar vesicles (GUVs) that allow for the detailed investigation of passive transport processes and mechanisms. This approach allows the concentration field to be directly observed, allowing membrane permeability to be determined easily from the transient concentration profile data. A series of molecules of increasing hydrophilicity was constructed, and the transport of these molecules into GUVs was observed. The observed permeability trend is consistent with Overton's rule. However, the values measured depart from the simple partition-diffusion proportionality model of passive transport. This technique is easy to implement and has great promise as an approach to measure membrane transport. It is optimally suited to precise quantitative measurements of the dependence of passive transport on membrane properties.

  6. Diurnal and seasonal variations of gas emissions in the inner coma of comet 67P/Churyumov-Gerasimenko observed with OSIRIS/Rosetta

    NASA Astrophysics Data System (ADS)

    La Forgia, F.; Lazzarin, M.; Bodewits, D.; A'Hearn, M. F.; Bertini, I.; Penasa, L.; Naletto, G.; Cremonese, G.; Massironi, M.; Ferri, F.; Frattin, E.; Lucchetti, A.; Ferrari, S.; Barbieri, C.

    2017-09-01

    The gas filters of OSIRIS/Wide Angle Camera (WAC) on board Rosetta spacecraft allowed to study the gaseous emissions of the inner coma of comet 67P/Churyumov-Gerasimenko. OH, NH, CN, NH2 and OI gas species have been monitored between January and September 2015, i.e. from 2.47 AU pre-perihelion, to 1.37 AU post-perihelion, allowing the study of seasonal variations. Each gas sequence covers slightly more than one comet rotation period allowing also the study of diurnal changes. We measured the gas column density between 1 and 3 km from the nucleus limb in the sunward direction. Results will be presented on the gas diurnal light curves and on the long-term variations such as the dependence and correlation with time, heliocentric distance, range, phase angle and sub-solar point. Gas ratios are studied searching for evidence of any compositional change with time and orbital evolution. We searched for connections between particular "active zones" on the nucleus surface. This study will be helpful in connecting ground based observations of 67P with Rosetta in situ observations.

  7. The Atacama Cosmology Telescope: Calibration with the Wilkinson Microwave Anisotropy Probe Using Cross-Correlations

    NASA Technical Reports Server (NTRS)

    Hajian, Amir; Acquaviva, Viviana; Ade, Peter A. R.; Aguirre, Paula; Amiri, Mandana; Appel, John William; Barrientos, L. Felipe; Battistelli, Elia S.; Bond, John R.; Brown, Ben; hide

    2011-01-01

    We present a new calibration method based on cross-correlations with the Wilkinson Microwave Anisotropy Probe (WMAP) and apply it to data from the Atacama Cosmology Telescope (ACT). ACT's observing strategy and mapmaking procedure allows an unbiased reconstruction of the modes in the maps over a wide range of multipoles. By directly matching the ACT maps to WMAP observations in the multipole range of 400 < I < 1000, we determine the absolute calibration with an uncertainty of 2% in temperature. The precise measurement of the calibration error directly impacts the uncertainties in the cosmological parameters estimated from the ACT power spectra. We also present a combined map based on ACT and WMAP data that has a high signal-to-noise ratio over a wide range of multipoles.

  8. Commentary on "A Review of e-Learning in Canada"

    ERIC Educational Resources Information Center

    Schwier, Richard A.

    2006-01-01

    In this commentary, Richard Schwier draws observations of what he believes are key issues in e-learning that come directly out of "A Review of e-Learning in Canada." However, much of the commentary is consumed by topics that haven't yet generated the volume or type of research necessary to allow the kind of compressed scrutiny that this…

  9. Imaging atomic-level random walk of a point defect in graphene

    NASA Astrophysics Data System (ADS)

    Kotakoski, Jani; Mangler, Clemens; Meyer, Jannik C.

    2014-05-01

    Deviations from the perfect atomic arrangements in crystals play an important role in affecting their properties. Similarly, diffusion of such deviations is behind many microstructural changes in solids. However, observation of point defect diffusion is hindered both by the difficulties related to direct imaging of non-periodic structures and by the timescales involved in the diffusion process. Here, instead of imaging thermal diffusion, we stimulate and follow the migration of a divacancy through graphene lattice using a scanning transmission electron microscope operated at 60 kV. The beam-activated process happens on a timescale that allows us to capture a significant part of the structural transformations and trajectory of the defect. The low voltage combined with ultra-high vacuum conditions ensure that the defect remains stable over long image sequences, which allows us for the first time to directly follow the diffusion of a point defect in a crystalline material.

  10. Flow Visualization by Elastic Light Scattering in the Boundary Layer of a Supersonic Flow

    NASA Technical Reports Server (NTRS)

    Herring, G. C.; Hillard, Mervin E., Jr.

    2000-01-01

    We demonstrate instantaneous flow visualization of the boundary layer region of a Mach 2.5 supersonic flow over a flat plate that is interacting with an impinging shock wave. Tests were performed in the Unitary Plan Wind Tunnel (UPWT) at NASA Langley Research Center. The technique is elastic light scattering using 10-nsec laser pulses at 532 nm. We emphasize that no seed material of any kind, including water (H2O), is purposely added to the flow. The scattered light comes from a residual impurity that normally exists in the flow medium after the air drying process. Thus, the technique described here differs from the traditional vapor-screen method, which is typically accomplished by the addition of extra H2O vapor to the airflow. The flow is visualized with a series of thin two-dimensional light sheets (oriented perpendicular to the streamwise direction) that are located at several positions downstream of the leading edge of the model. This geometry allows the direct observation of the unsteady flow structure in the spanwise dimension of the model and also allows the indirect observation of the boundary layer growth in the streamwise dimension.

  11. Direct trabecular meshwork imaging in porcine eyes through multiphoton gonioscopy

    PubMed Central

    Masihzadeh, Omid; Ammar, David A.; Kahook, Malik Y.; Gibson, Emily A.; Lei, Tim C.

    2013-01-01

    Abstract. The development of technologies to characterize the ocular aqueous outflow system (AOS) is important for the understanding of the pathophysiology of glaucoma. Multiphoton microscopy (MPM) offers the advantage of high-resolution, label-free imaging with intrinsic image contrast because the emitted signals result from the specific biomolecular content of the tissue. Previous attempts to use MPM to image the murine irido-corneal region directly through the sclera have suffered from degradation in image resolution due to scattering of the focused laser light. As a result, transscleral MPM has limited ability to observe fine structures in the AOS. In this work, the porcine irido-corneal angle was successfully imaged through the transparent cornea using a gonioscopic lens to circumvent the highly scattering scleral tissue. The resulting high-resolution images allowed the detailed structures in the trabecular meshwork (TM) to be observed. Multimodal imaging by two-photon autofluorescence and second harmonic generation allowed visualization of different features in the TM without labels and without disruption of the TM or surrounding tissues. MPM gonioscopy is a promising noninvasive imaging tool for high-resolution studies of the AOS, and research continues to explore the potential for future clinical applications in humans. PMID:23515864

  12. Direct trabecular meshwork imaging in porcine eyes through multiphoton gonioscopy.

    PubMed

    Masihzadeh, Omid; Ammar, David A; Kahook, Malik Y; Gibson, Emily A; Lei, Tim C

    2013-03-01

    The development of technologies to characterize the ocular aqueous outflow system (AOS) is important for the understanding of the pathophysiology of glaucoma. Multiphoton microscopy (MPM) offers the advantage of high-resolution, label-free imaging with intrinsic image contrast because the emitted signals result from the specific biomolecular content of the tissue. Previous attempts to use MPM to image the murine irido-corneal region directly through the sclera have suffered from degradation in image resolution due to scattering of the focused laser light. As a result, transscleral MPM has limited ability to observe fine structures in the AOS. In this work, the porcine irido-corneal angle was successfully imaged through the transparent cornea using a gonioscopic lens to circumvent the highly scattering scleral tissue. The resulting high-resolution images allowed the detailed structures in the trabecular meshwork (TM) to be observed. Multimodal imaging by two-photon autofluorescence and second harmonic generation allowed visualization of different features in the TM without labels and without disruption of the TM or surrounding tissues. MPM gonioscopy is a promising noninvasive imaging tool for high-resolution studies of the AOS, and research continues to explore the potential for future clinical applications in humans.

  13. Direct trabecular meshwork imaging in porcine eyes through multiphoton gonioscopy

    NASA Astrophysics Data System (ADS)

    Masihzadeh, Omid; Ammar, David A.; Kahook, Malik Y.; Gibson, Emily A.; Lei, Tim C.

    2013-03-01

    The development of technologies to characterize the ocular aqueous outflow system (AOS) is important for the understanding of the pathophysiology of glaucoma. Multiphoton microscopy (MPM) offers the advantage of high-resolution, label-free imaging with intrinsic image contrast because the emitted signals result from the specific biomolecular content of the tissue. Previous attempts to use MPM to image the murine irido-corneal region directly through the sclera have suffered from degradation in image resolution due to scattering of the focused laser light. As a result, transscleral MPM has limited ability to observe fine structures in the AOS. In this work, the porcine irido-corneal angle was successfully imaged through the transparent cornea using a gonioscopic lens to circumvent the highly scattering scleral tissue. The resulting high-resolution images allowed the detailed structures in the trabecular meshwork (TM) to be observed. Multimodal imaging by two-photon autofluorescence and second harmonic generation allowed visualization of different features in the TM without labels and without disruption of the TM or surrounding tissues. MPM gonioscopy is a promising noninvasive imaging tool for high-resolution studies of the AOS, and research continues to explore the potential for future clinical applications in humans.

  14. Direct Visualization of Aggregate Morphology and Dynamics in a Model Soil Organic–Mineral System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hufschmid, Ryan; Newcomb, Christina J.; Grate, Jay W.

    Interactions between mineral surfaces and organic matter are ubiquitous in soils and the environment. Through both physical and chemical mechanisms, organic-mineral assemblages prevent decomposition of soil organic matter by limiting accessibility or reducing efficacy of enzymes and microbes. To understand the mechanisms underlying organic-mineral interactions, researchers have begun to interrogate these systems at smaller length scales. Current techniques that maintain a hydrated state and allow researchers to characterize nanometer length scales are limited. Here we chose a model organic-mineral system and performed complementary imaging techniques that enable direct nanoscale observations in environmentally relevant conditions: cryogenic TEM and in-situ liquid cellmore » TEM. We observed a three-fold increase in aggregate size of goethite nanoparticles upon addition of a model organic phosphate ligand and quantification of nanoparticle orientation reveals a preference for side-to-side interactions independent of the addition of an organic ligand. Additionally, in-situ liquid cell TEM experiments provides a dynamic view of the interactions allowing us to report velocities of mineral assemblages during aggregation and disaggregation, which could potentially provide binding energetics and kinetic parameters about organic-mineral and mineral-mineral systems.« less

  15. Tunneling dynamics of double proton transfer in formic acid and benzoic acid dimers

    NASA Astrophysics Data System (ADS)

    Smedarchina, Zorka; Fernández-Ramos, Antonio; Siebrand, Willem

    2005-04-01

    Direct dynamics calculations based on instanton techniques are reported of tunneling splittings due to double proton transfer in formic and benzoic acid dimers. The results are used to assign the observed splittings to levels for which the authors of the high-resolution spectra could not provide a definitive assignment. In both cases the splitting is shown to be due mainly to the zero-point level rather than to the vibrationally or electronically excited level whose spectrum was investigated. This leads to zero-point splittings of 375MHz for (DCOOH)2 and 1107MHz for the benzoic acid dimer. Thus, contrary to earlier calculations, it is found that the splitting is considerably larger in the benzoic than in the formic acid dimer. The calculations are extended to solid benzoic acid where the asymmetry of the proton-transfer potential induced by the crystal can be overcome by suitable doping. This has allowed direct measurement of the interactions responsible for double proton transfer, which were found to be much larger than those in the isolated dimer. To account for this observation both static and dynamic effects of the crystal forces on the intradimer hydrogen bonds are included in the calculations. The same methodology, extended to higher temperatures, is used to calculate rate constants for HH, HD, and DD transfers in neat benzoic acid crystals. The results are in good agreement with reported experimental rate constants measured by NMR relaxometry and, if allowance is made for small structural changes induced by doping, with the transfer matrix elements observed in doped crystals. Hence the method used allows a unified description of tunneling splittings in the gas phase and in doped crystals as well as of transfer rates in neat crystals.

  16. Direct Observations of Interstellar H, He, and O by the Interstellar Boundary Explorer (Invited)

    NASA Astrophysics Data System (ADS)

    Moebius, E.; Bochsler, P. A.; Bzowski, M.; Crew, G. B.; Funsten, H. O.; Fuselier, S. A.; Ghielmetti, A.; Heirtzler, D.; Izmodenov, V.; Kubiak, M.; Kucharek, H.; Lee, M. A.; Leonard, T.; McComas, D. J.; Petersen, L.; Saul, L. A.; Scheer, J.; Schwadron, N. A.; Witte, M.; Wurz, P.

    2009-12-01

    Due to the motion of the Sun relative to its neighborhood, the neutral gas of the local in-terstellar medium (LISM) flows through the inner heliosphere where it is subject to ioni-zation, the Sun’s gravity, and radiation pressure. Observing the resulting spatial distribu-tion and flow pattern of several interstellar gas species with UV backscatter, pickup ion, and neutral atom imaging techniques allows us to unravel the physical conditions of the LISM and its interaction with the heliosphere. Imaging of the neutral gas flow directly with energetic neutral atom (ENA) cameras yields the most accurate account of the ki-netic parameters of the interstellar gas, but so far this has been carried out only for He using Ulysses GAS. IBEX, which was launched in October 2008, provides the capability for simultaneous flow observations of several interstellar species with its triple-time-of-flight IBEX-Lo sensor. Because H and O are strongly affected by the heliospheric inter-face while He is not, a direct comparison between these species enables an independent assessment of the slowdown and heating processes in the outer heliosheath. Likewise, IBEX observations will constrain models of the heliospheric interaction and provide a test of the heliospheric asymmetry - recently inferred from Voyager and SOHO SWAN observations - that is seen as an indicator for the interstellar magnetic field direction. During the first half year of its mission IBEX has observed the interstellar He, O, and H flow. We will present an overview and preliminary analysis of these first interstellar mul-tispecies scans of the interstellar gas flow in spring and fall 2009.

  17. Using direct clinical observation to assess the quality of cesarean delivery in Afghanistan: an exploratory study

    PubMed Central

    2014-01-01

    Background As part of a National Emergency Obstetric and Newborn Care (EmONC) Needs Assessment, a special study was undertaken in July 2010 to examine the quality of cesarean deliveries in Afghanistan and examine the utility of direct clinical observation as an assessment method in low-resource settings. Methods This cross-sectional assessment of the quality of cesareans at 14 facilities in Afghanistan included a survey of surgeons regarding their routine cesarean practices, direct observation of 29 cesarean deliveries and comparison of observations with facility records for 34 additional cesareans conducted during the 3 days prior to the observation period at each facility. For both observed cases and record reviews, we assessed time intervals between specified points of care-arrival to the ward, first evaluation, detection of a complication, decision for cesarean, incision, and birth. Results All time intervals with the exception of “decision to skin incision” were longer in the record reviews than in observed cases. Prior cesarean was the most common primary indication for all cases. All mothers in both groups observed survived through one hour postpartum. Among newborns there were two stillbirths (7%) in observed births and seven (21%) record reviews. Although our sample is too small to show statistical significance, the difference is noteworthy. In six of the reviewed cesareans resulting in stillbirth, a fetal heart rate was recorded in the operating theater, although four were recorded as macerated. For the two fresh stillbirths, the cesarean surgeries were recorded as scheduled and not urgent. Conclusions Direct observation of cesarean deliveries enabled us to assess a number of preoperative, postoperative, and intraoperative procedures that are often not described in medical records in low resource settings. Comparison of observations with findings from provider interviews and facility records allowed us to infer whether observed practices were typical of providers and facilities and detect potential Hawthorne effects. PMID:24886143

  18. Visualization of TlBr ionic transport mechanism by the Accelerated Device Degradation technique

    NASA Astrophysics Data System (ADS)

    Datta, Amlan; Becla, Piotr; Motakef, Shariar

    2015-06-01

    Thallium Bromide (TlBr) is a promising gamma radiation semiconductor detector material. However, it is an ionic semiconductor and suffers from polarization. As a result, TlBr devices degrade rapidly at room temperature. Polarization is associated with the flow of ionic current in the crystal under electrical bias, leading to the accumulation of charged ions at the device's electrical contacts. We report a fast and reliable direct characterization technique to identify the effects of various growth and post-growth process modifications on the polarization process. The Accelerated Device Degradation (ADD) characterization technique allows direct observation of nucleation and propagation of ionic transport channels within the TlBr crystals under applied bias. These channels are observed to be initiated both directly under the electrode as well as away from it. The propagation direction is always towards the anode indicating that Br- is the mobile diffusing species within the defect channels. The effective migration energy of the Br- ions was calculated to be 0.33±0.03 eV, which is consistent with other theoretical and experimental results.

  19. Anisotropy in Fracking: A Percolation Model for Observed Microseismicity

    NASA Astrophysics Data System (ADS)

    Norris, J. Quinn; Turcotte, Donald L.; Rundle, John B.

    2015-01-01

    Hydraulic fracturing (fracking), using high pressures and a low viscosity fluid, allow the extraction of large quantiles of oil and gas from very low permeability shale formations. The initial production of oil and gas at depth leads to high pressures and an extensive distribution of natural fractures which reduce the pressures. With time these fractures heal, sealing the remaining oil and gas in place. High volume fracking opens the healed fractures allowing the oil and gas to flow to horizontal production wells. We model the injection process using invasion percolation. We use a 2D square lattice of bonds to model the sealed natural fractures. The bonds are assigned random strengths and the fluid, injected at a point, opens the weakest bond adjacent to the growing cluster of opened bonds. Our model exhibits burst dynamics in which the clusters extend rapidly into regions with weak bonds. We associate these bursts with the microseismic activity generated by fracking injections. A principal object of this paper is to study the role of anisotropic stress distributions. Bonds in the y-direction are assigned higher random strengths than bonds in the x-direction. We illustrate the spatial distribution of clusters and the spatial distribution of bursts (small earthquakes) for several degrees of anisotropy. The results are compared with observed distributions of microseismicity in a fracking injection. Both our bursts and the observed microseismicity satisfy Gutenberg-Richter frequency-size statistics.

  20. An airborne system for vortex flow visualization on the F-18 high-alpha research vehicle

    NASA Technical Reports Server (NTRS)

    Curry, Robert E.; Richwine, David M.

    1988-01-01

    A flow visualization system for the F-18 high-alpha research vehicle is described which allows direct observation of the separated vortex flows over a wide range of flight conditions. The system consists of a smoke generator system, on-board photographic and video systems, and instrumentation. In the present concept, smoke is entrained into the low-pressure vortex core, and vortice breakdown is indicated by a rapid diffusion of the smoke. The resulting pattern is observed using photographic and video images and is correlated with measured flight conditions.

  1. Observation of Spin-Polarons in a strongly interacting Fermi liquid

    NASA Astrophysics Data System (ADS)

    Zwierlein, Martin

    2009-03-01

    We have observed spin-polarons in a highly imbalanced mixture of fermionic atoms using tomographic RF spectroscopy. Feshbach resonances allow to freely tune the interactions between the two spin states involved. A single spin down atom immersed in a Fermi sea of spin up atoms can do one of two things: For strong attraction, it can form a molecule with exactly one spin up partner, but for weaker interaction it will spread its attraction and surround itself with a collection of majority atoms. This spin down atom ``dressed'' with a spin up cloud constitutes the spin-polaron. We have observed a striking spectroscopic signature of this quasi-particle for various interaction strengths, a narrow peak in the spin down spectrum that emerges above a broad background. The narrow width signals a long lifetime of the spin-polaron, much longer than the collision rate with spin up atoms, as it must be for a proper quasi-particle. The peak position allows to directly measure the polaron energy. The broad pedestal at high energies reveals physics at short distances and is thus ``molecule-like'': It is exactly matched by the spin up spectra. The comparison with the area under the polaron peak allows to directly obtain the quasi-particle weight Z. We observe a smooth transition from polarons to molecules. At a critical interaction strength of 1/kFa = 0.7, the polaron peak vanishes and spin up and spin down spectra exactly match, signalling the formation of molecules. This is the same critical interaction strength found earlier to separate a normal Fermi mixture from a superfluid molecular Bose-Einstein condensate. The spin-polarons determine the low-temperature phase diagram of imbalanced Fermi mixtures. In principle, polarons can interact with each other and should, at low enough temperatures, form a superfluid of p-wave pairs. We will present a first indication for interactions between polarons.

  2. Active black holes: Relevant plasma structures, regimes and processes involving all phase space

    NASA Astrophysics Data System (ADS)

    Coppi, Bruno

    2011-03-01

    The presented theory is motivated by the growing body of experimental information on the characteristics, connected with relevant spectral, time, and space resolutions, of the radiation emission from objects considered as rotating black holes. In the immediate surroundings of these objects, three plasma regions are identified: an innermost Buffer Region, an intermediate Three-regime Region, and a Structured Peripheral Region. In the last region, a Composite Disk Structure made of a sequence of plasma rings corresponding to the formation of closed magnetic surfaces is considered to be present and to allow intermittent accretion flows along the relevant separatrices. The nonlinear ``Master Equation'' describing composite disk structures is derived and solved in appropriate asymptotic limits. A ring configuration, depending on the state of the plasma at the microscopic level: (i) can be excluded from forming given the strongly nonthermal nature of the electron distribution (in momentum space) within the Three-regime Region allowing the onset of a spiral structure; the observed High Frequency Quasi Periodic Oscillations are associated with these tridimensional structures; (ii) may be allowed to propagate to the outer edge of the Buffer Region where successive rings carrying currents in opposite directions are ejected vertically (in opposite directions) and originate the observed jets; or (iii) penetrates in the Three-regime Region and is dissipated before reaching the outer edge of the Buffer Region. The absence of a coherent composite disk structure guiding accretion in the presence of a significant magnetic field background is suggested to characterize quiescent black holes.

  3. The quest for infall in star-forming regions

    NASA Astrophysics Data System (ADS)

    Wyrowski, Friedrich

    2018-06-01

    Observation of infall is key to our understanding of the accretion process in star formation. High-resolution spectroscopy allows us to resolve molecular lines originating from the dense molecular envelopes of the forming (proto-) stars to deduce the kinematics of the gas. In this contribution, I'll describe how SOFIA can significantly contribute to the quest for and characterisation of infall by providing unique access to molecular lines at THz frequencies that allow red-shifted absorption studies as direct probe of infall and that provide access to fine structure and high excitation lines that probe outflowing gas as indirect evidence for accretion. In particular, I will report on a recent study using the GREAT high-spectral resolution instrument on-board of SOFIA to observe ammonia at 1.8 THz. Eight out of eleven observed massive clumps have been found with red-shifted absorption that is indicative of infall motions. This fraction of 72% is substantially higher than that found in past searches for the blue-skewed profile signature. The observations show that infall on clump scales is ubiquitous through a wide range of evolutionary stages.

  4. Phonon-magnon interaction in low dimensional quantum magnets observed by dynamic heat transport measurements.

    PubMed

    Montagnese, Matteo; Otter, Marian; Zotos, Xenophon; Fishman, Dmitry A; Hlubek, Nikolai; Mityashkin, Oleg; Hess, Christian; Saint-Martin, Romuald; Singh, Surjeet; Revcolevschi, Alexandre; van Loosdrecht, Paul H M

    2013-04-05

    Thirty-five years ago, Sanders and Walton [Phys. Rev. B 15, 1489 (1977)] proposed a method to measure the phonon-magnon interaction in antiferromagnets through thermal transport which so far has not been verified experimentally. We show that a dynamical variant of this approach allows direct extraction of the phonon-magnon equilibration time, yielding 400 μs for the cuprate spin-ladder system Ca(9)La(5)Cu(24)O(41). The present work provides a general method to directly address the spin-phonon interaction by means of dynamical transport experiments.

  5. Visualization of Electrical Field of Electrode Using Voltage-Controlled Fluorescence Release

    PubMed Central

    Jia, Wenyan; Wu, Jiamin; Gao, Di; Wang, Hao; Sun, Mingui

    2016-01-01

    In this study we propose an approach to directly visualize electrical current distribution at the electrode-electrolyte interface of a biopotential electrode. High-speed fluorescent microscopic images are acquired when an electric potential is applied across the interface to trigger the release of fluorescent material from the surface of the electrode. These images are analyzed computationally to obtain the distribution of the electric field from the fluorescent intensity of each pixel. Our approach allows direct observation of microscopic electrical current distribution around the electrode. Experiments are conducted to validate the feasibility of the fluorescent imaging method. PMID:27253615

  6. Anomalous transport scaling in the DIII-D tokamak matched by supercomputer simulation.

    PubMed

    Candy, J; Waltz, R E

    2003-07-25

    Gyrokinetic simulation of tokamak transport has evolved sufficiently to allow direct comparison of numerical results with experimental data. It is to be emphasized that only with the simultaneous inclusion of many distinct and complex effects can this comparison realistically be made. Until now, numerical studies of tokamak microturbulence have been restricted to either (a) flux tubes or (b) electrostatic fluctuations. Using a newly developed global electromagnetic solver, we have been able to recover via direct simulation the Bohm-like scaling observed in DIII-D L-mode discharges. We also match, well within experimental uncertainty, the measured energy diffusivities.

  7. X-ray tomographic microscopy analysis of the dendrite orientation transition in Al-Zn

    NASA Astrophysics Data System (ADS)

    Friedli, Jonathan; Fife, Julie L.; Di Napoli, Paolo; Rappaz, Michel

    2012-07-01

    Recently, Gonzales and Rappaz [Met. Mat. Trans. A37:2797, 2006] showed the influence of an increasing zinc content on the growth directions of aluminum dendrites. langle100rangle and langle110rangle dendrites were observed below 25wt.% and above 55wt.% zinc, respectively, whereas textured seaweeds and langle320rangle dendrites were observed at intermediate compositions. Considering the complexity of these structures, it is necessary to first characterize them in further details and second, to model them using the phase field method. The so-called Dendrite Orientation Transition (DOT) was thus reinvestigated in quenched Bridgman solidification samples. The combination of X-ray tomographic microscopy and electron backscattered diffraction (EBSD) analysis on a whole range of compositions, from 5 to 90wt.% Zn, allowed insights with unprecedented details about texture, growth directions and mechanisms of the aforementioned structures. We show that seaweeds rather than dendrites are found at all intermediate compositions. Their growth was confirmed to be constrained within a (100) symmetry plane. However, new findings indicate that the observed macroscopic texture does not necessarily correspond to the actual growth directions of the microstructure. Further, it seems to operate by an alternating growth direction mechanism and could be linked to the competition between the langle100rangle and langle110rangle characters of regular dendrites observed at the limits of the DOT. These characters, as well as 3D seaweeds, are observed in phase-field simulations of equiaxed growth and directional solidification, respectively. This study emphasizes the importance of accurate experimental data to validate numerical models and details the progress that such combinations provide for the understanding of growth mechanisms.

  8. Direct observation of multistep energy transfer in LHCII with fifth-order 3D electronic spectroscopy.

    PubMed

    Zhang, Zhengyang; Lambrev, Petar H; Wells, Kym L; Garab, Győző; Tan, Howe-Siang

    2015-07-31

    During photosynthesis, sunlight is efficiently captured by light-harvesting complexes, and the excitation energy is then funneled towards the reaction centre. These photosynthetic excitation energy transfer (EET) pathways are complex and proceed in a multistep fashion. Ultrafast two-dimensional electronic spectroscopy (2DES) is an important tool to study EET processes in photosynthetic complexes. However, the multistep EET processes can only be indirectly inferred by correlating different cross peaks from a series of 2DES spectra. Here we directly observe multistep EET processes in LHCII using ultrafast fifth-order three-dimensional electronic spectroscopy (3DES). We measure cross peaks in 3DES spectra of LHCII that directly indicate energy transfer from excitons in the chlorophyll b (Chl b) manifold to the low-energy level chlorophyll a (Chl a) via mid-level Chl a energy states. This new spectroscopic technique allows scientists to move a step towards mapping the complete complex EET processes in photosynthetic systems.

  9. Can the use of pulsed direct current induce oscillation in the applied pressure during spark plasma sintering?

    PubMed Central

    Salamon, David; Eriksson, Mirva; Nygren, Mats; Shen, Zhijian

    2012-01-01

    The spark plasma sintering (SPS) process is known for its rapid densification of metals and ceramics. The mechanism behind this rapid densification has been discussed during the last few decades and is yet uncertain. During our SPS experiments we noticed oscillations in the applied pressure, related to a change in electric current. In this study, we investigated the effect of pulsed electrical current on the applied mechanical pressure and related changes in temperature. We eliminated the effect of sample shrinkage in the SPS setup and used a transparent quartz die allowing direct observation of the sample. We found that the use of pulsed direct electric current in our apparatus induces pressure oscillations with the amplitude depending on the current density. While sintering Ti samples we observed temperature oscillations resulting from pressure oscillations, which we attribute to magnetic forces generated within the SPS apparatus. The described current–pressure–temperature relations might increase understanding of the SPS process. PMID:27877472

  10. Direct evidence of double-slope power spectra in the high-latitude ionospheric plasma

    NASA Astrophysics Data System (ADS)

    Spicher, A.; Miloch, W. J.; Moen, J. I.

    2014-03-01

    We report direct observations of the double-slope power spectra for plasma irregularities in the F layer of the polar ionosphere. The investigation of cusp irregularities ICI-2 sounding rocket, which was launched into the polar cusp ionosphere, intersected enhanced plasma density regions with decameter-scale irregularities. Density measurements at unprecedented high resolution with multi-Needle Langmuir Probes allowed for a detailed study of the plasma irregularities down to kinetic scales. Spectral analysis reveals double-slope power spectra for regions of enhanced fluctuations associated mainly with density gradients, with the steepening of the spectra occurring close to the oxygen gyrofrequency. These findings are further supported with the first results from the ICI-3 rocket, which flew through regions with strong precipitation and velocity shears. Previously, double-slope spectra have been observed in the equatorial ionosphere. The present work gives a direct evidence that the double-slope power spectra can be common in the high-latitude ionosphere.

  11. Stochastic processes in gravitropism.

    PubMed

    Meroz, Yasmine; Bastien, Renaud

    2014-01-01

    In this short review we focus on the role of noise in gravitropism of plants - the reorientation of plants according to the direction of gravity. We briefly introduce the conventional picture of static gravisensing in cells specialized in sensing. This model hinges on the sedimentation of statoliths (high in density and mass relative to other organelles) to the lowest part of the sensing cell. We then present experimental observations that cannot currently be understood within this framework. Lastly we introduce some current alternative models and directions that attempt to incorporate and interpret these experimental observations, including: (i) dynamic sensing, where gravisensing is suggested to be enhanced by stochastic events due to thermal and mechanical noise. These events both effectively lower the threshold of response, and lead to small-distance sedimentation, allowing amplification, and integration of the signal. (ii) The role of the cytoskeleton in signal-to-noise modulation and (iii) in signal transduction. In closing, we discuss directions that seem to either not have been explored, or that are still poorly understood.

  12. Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules

    NASA Astrophysics Data System (ADS)

    Imai, Hiroshi; Shima, Tomohiro; Sutoh, Kazuo; Walker, Matthew L.; Knight, Peter J.; Kon, Takahide; Burgess, Stan A.

    2015-09-01

    Cytoplasmic dynein is a dimeric AAA+ motor protein that performs critical roles in eukaryotic cells by moving along microtubules using ATP. Here using cryo-electron microscopy we directly observe the structure of Dictyostelium discoideum dynein dimers on microtubules at near-physiological ATP concentrations. They display remarkable flexibility at a hinge close to the microtubule binding domain (the stalkhead) producing a wide range of head positions. About half the molecules have the two heads separated from one another, with both leading and trailing motors attached to the microtubule. The other half have the two heads and stalks closely superposed in a front-to-back arrangement of the AAA+ rings, suggesting specific contact between the heads. All stalks point towards the microtubule minus end. Mean stalk angles depend on the separation between their stalkheads, which allows estimation of inter-head tension. These findings provide a structural framework for understanding dynein's directionality and unusual stepping behaviour.

  13. Observer's Interface for Solar System Target Specification

    NASA Astrophysics Data System (ADS)

    Roman, Anthony; Link, Miranda; Moriarty, Christopher; Stansberry, John A.

    2016-10-01

    When observing an asteroid or comet with HST, it has been necessary for the observer to manually enter the target's orbital elements into the Astronomer's Proposal Tool (APT). This allowed possible copy/paste transcription errors from the observer's source of orbital elements data. In order to address this issue, APT has now been improved with the capability to identify targets in and then download orbital elements from JPL Horizons. The observer will first use a target name resolver to choose the intended target from the Horizons database, and then download the orbital elements from Horizons directly into APT. A manual entry option is also still retained if the observer does not wish to use elements from Horizons. This new capability is available for HST observing, and it will also be supported for JWST observing. The poster shows examples of this new interface.

  14. Observer's Interface for Solar System Target Specification

    NASA Astrophysics Data System (ADS)

    Roman, Anthony; Link, Miranda; Moriarty, Christopher; Stansberry, John A.

    2016-01-01

    When observing an asteroid or comet with HST, it has been necessary for the observer to manually enter the target's orbital elements into the Astronomer's Proposal Tool (APT). This allowed possible copy/paste transcription errors from the observer's source of orbital elements data. In order to address this issue, APT has now been improved with the capability to identify targets in and then download orbital elements from JPL Horizons. The observer will first use a target name resolver to choose the intended target from the Horizons database, and then download the orbital elements from Horizons directly into APT. A manual entry option is also still retained if the observer does not wish to use elements from Horizons. This new capability is available for HST observing, and it will also be supported for JWST observing. The poster shows examples of this new interface.

  15. 3-component beamforming analysis of ambient seismic noise field for Love and Rayleigh wave source directions

    NASA Astrophysics Data System (ADS)

    Juretzek, Carina; Hadziioannou, Céline

    2014-05-01

    Our knowledge about common and different origins of Love and Rayleigh waves observed in the microseism band of the ambient seismic noise field is still limited, including the understanding of source locations and source mechanisms. Multi-component array methods are suitable to address this issue. In this work we use a 3-component beamforming algorithm to obtain source directions and polarization states of the ambient seismic noise field within the primary and secondary microseism bands recorded at the Gräfenberg array in southern Germany. The method allows to distinguish between different polarized waves present in the seismic noise field and estimates Love and Rayleigh wave source directions and their seasonal variations using one year of array data. We find mainly coinciding directions for the strongest acting sources of both wave types at the primary microseism and different source directions at the secondary microseism.

  16. Electromagnetic polarization-controlled perfect switching effect with high-refractive-index dimers and the beam-splitter configuration

    PubMed Central

    Barreda, Ángela I.; Saleh, Hassan; Litman, Amelie; González, Francisco; Geffrin, Jean-Michel; Moreno, Fernando

    2017-01-01

    Sub-wavelength particles made from high-index dielectrics, either individual or as ensembles, are ideal candidates for multifunctional elements in optical devices. Their directionality effects are traditionally analysed through forward and backward measurements, even if these directions are not convenient for in-plane scattering practical purposes. Here we present unambiguous experimental evidence in the microwave range that for a dimer of HRI spherical particles, a perfect switching effect is observed out of those directions as a consequence of the mutual particle electric/magnetic interaction. The binary state depends on the excitation polarization. Its analysis is performed through the linear polarization degree of scattered radiation at a detection direction perpendicular to the incident direction: the beam-splitter configuration. The scaling property of Maxwell's equations allows the generalization of our results to other frequency ranges and dimension scales, for instance, the visible and the nanometric scale. PMID:28051061

  17. Non-destructive digital imaging in poplar allows detailed analysis of adventitious rooting dynamics

    Treesearch

    R.J. Kodrzycki; R.B. Michaels; A.L. Friend; R.S. Zalesny; Ch.P. Mawata; D.W. McDonald

    2008-01-01

    The dynamics of root formation are difficult to observe directly over time without disturbing the rooting environment. A novel system for a non-destructive, non-invasive root analysis (RootViz FS, Phenotype Screening Corp.) was evaluated for its ability to analyze root formation from cuttings over a 32 day period in three poplar genotypes (DN70, P. Deltoides x...

  18. The SPEDE spectrometer

    NASA Astrophysics Data System (ADS)

    Papadakis, P.; Cox, D. M.; O'Neill, G. G.; Borge, M. J. G.; Butler, P. A.; Gaffney, L. P.; Greenlees, P. T.; Herzberg, R.-D.; Illana, A.; Joss, D. T.; Konki, J.; Kröll, T.; Ojala, J.; Page, R. D.; Rahkila, P.; Ranttila, K.; Thornhill, J.; Tuunanen, J.; Van Duppen, P.; Warr, N.; Pakarinen, J.

    2018-03-01

    The electron spectrometer, SPEDE, has been developed and will be employed in conjunction with the Miniball spectrometer at the HIE-ISOLDE facility, CERN. SPEDE allows for direct measurement of internal conversion electrons emitted in-flight, without employing magnetic fields to transport or momentum filter the electrons. Together with the Miniball spectrometer, it enables simultaneous observation of γ rays and conversion electrons in Coulomb excitation experiments using radioactive ion beams.

  19. A Student-Centered, Inquiry-Based Approach to Young's Double-Slit Experiment (and Other Investigations of Light's Wave Character)

    ERIC Educational Resources Information Center

    Meyer, Daniel Z.

    2017-01-01

    Young's double-slit experiment is one of the most historically significant works in physics, and one that is easily done in an introductory physics class. It is also an excellent example of an investigation that allows us to infer the nature of phenomena beyond direct observation. Unfortunately, perhaps because of this, it is often also an…

  20. Correlating Solar Wind Modulation with Ionospheric Variability at Mars from MEX and MAVEN Observations

    NASA Astrophysics Data System (ADS)

    Kopf, A. J.; Morgan, D. D.; Halekas, J. S.; Ruhunusiri, S.; Gurnett, D. A.; Connerney, J. E. P.

    2017-12-01

    The synthesis of observations by the Mars Express and Mars Atmosphere and Volatiles Evolution (MAVEN) spacecraft allows for a unique opportunity to study variability in the Martian ionosphere from multiple perspectives. One major source for this variability is the solar wind. Due to its elliptical orbit which precesses over time, MAVEN periodically spends part of its orbit outside the Martian bow shock, allowing for direct measurements of the solar wind impacting the Martian plasma environment. When the Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) instrument aboard Mars Express is simultaneously sounding the ionosphere, the influence from changes in the solar wind can be observed. Previous studies have suggested a positive correlation, connecting ionospheric density to the solar wind proton flux, but depended on Earth-based measurements for solar wind conditions. More recently, research has indicated that observations of ionospheric variability from these two spacecraft can be connected in special cases, such as shock wave impacts or specific solar wind magnetic field orientations. Here we extend this to more general solar wind conditions and examine how changes in the solar wind properties measured by MAVEN instruments correlate with ionospheric structure and dynamics observed simultaneously in MARSIS remote and local measurements.

  1. Determining thin film properties by fitting optical transmittance

    NASA Astrophysics Data System (ADS)

    Klein, J. D.; Yen, A.; Cogan, S. F.

    1990-08-01

    The optical transmission spectra of rf sputtered tungsten oxide films on glass substrates were modeled to determine absorption edge behavior, film thickness, and index of refraction. Removal of substrate reflection and absorption phenomena from the experimental spectra allowed direct examination of thin film optical characteristics. The interference fringe pattern allows determination of the film thickness and the dependence of the real index of refraction on wavelength. Knowledge of the interference fringe behavior in the vicinity of the absorption edge was found essential to unambiguous determination of the optical band gap. In particular, the apparently random deviations commonly observed in the extrapolation of as-acquired data are eliminated by explicitly considering interference fringe phenomena. The multivariable optimization fitting scheme employed allows air-film-substrate reflection losses to be compensated without making reflectance measurements.

  2. The plumbotectonic model for Pb isotopic systematics among major terrestrial reservoirs - A case for bi-directional transport

    NASA Astrophysics Data System (ADS)

    Zartman, Robert E.; Haines, Sara M.

    1988-06-01

    Version IV of plumbotectonics expands and refines the original model of DOE and ZARTMAN (1979) and ZARTMAN and DOE (1981) for explaining Pb (Sr, and Nd) isotopic systematics among major terrestrial reservoirs. A case for bi-directional transport among reservoirs is based on the observed isotopic compositions for different tectonic settings, and finds a rationale in the kinetics of plate tectonics. Chemical fractionation and radioactive decay create isotopic differences during periods of isolation of one reservoir from another, whereas dynamic processes allowing mixing between reservoirs tend to reduce these differences. Observed isotopic characteristics reflect a balance between these opposing tendencies and provide constraints on the extent and timing of fractionation and mixing processes. Plumbotectonics does not require interaction with a lower mantle or core reservoir over most of the Earth's lifetime, and, in fact, achieves a material balance consistent with no such exchange of material. Important evidence of the amount and timing of crustal recycling, and of the residence times of mantle heterogeneities lies in the coupled 207Pb /204Pb- 206 Pb 204Pb systematics. We believe that examination of the published data base fully supports our contention of significant bi-directional transport of material among terrestrial reservoirs. Plumbotectonics allows us to explore many aspects of reservoir interaction, and to identify parameters that provide meaningful constraints on mantle-crust differentiation. We put forth a compromise fit to many of the model variables in version IV, which can serve as a reference for future work.

  3. Measuring the High-Mass IMF in Low-Metallicity Dwarf Galaxies

    NASA Astrophysics Data System (ADS)

    Weisz, Daniel

    2017-08-01

    We propose to measure the stellar initial mass function above >1-2 Msun in 46 nearby dwarf galaxies with archival HST observations. This novel approach leverages the redundant age information provided by the main sequence and blue core helium burning stars <500 years old to break the well-known degeneracy between the IMF and star formation history (SFH), enabling a direct measurement of the high-mass IMF in dwarf galaxies. We will be able to constrain the high-mass IMF slope to a precision better than 0.1 to 0.3 dex in each galaxy. Our sample spans a factor of 6 in metallicity ( 5-30% Zsun), 4 decades in star formation rate, and 3 decades in both stellar and gas mass, allowing us to explore the IMF over a wide range of extreme environments.Current observational evidence suggests that nearby dwarf galaxies are the most likely candidates to host significant and systematic variations in the high-mass IMF (e.g., Halpha/UV ratios). However, to date there have been no direct measurements of the high-mass IMF in environments with lower star formation rates and/or more metal poor than the Magellanic Clouds. Our program remedies this shortcoming allowing us to (1) make the first-ever measurement of the high-mass IMF in extremely metal-poor environments; (2) empirically quantify environmental the (lack of) variations in the high-mass IMF; (3) directly test the integrated galactic mass initial mass function (IGIMF), which predicts environmental sensitivity of the IMF in dwarf galaxies.

  4. [Nursing role in prevention of Ventilator Associated Pneumonia: Spanish project "Neumonìa Zero"].

    PubMed

    Pinto, Cristina; Reig Valero, Roberto; Iadeluca, Antonio; Lomuscio, Sonia; Caldarulo, Tiziana; Sponton, Anna

    2015-01-01

    The incidence of Ventilator Associated Pneumonia (VAP) varies between 8 and 28% on patients with invasive mechanical ventilation, and it is associated with high mortality rates. The international literature indicates that the VAP has some risk factors that cannot be changed and some other that are closely related to nursing care procedures. The aim of this study is to analyze compliance level to the protocol of nursing prevention of the VAP in the ICU of "General Hospital" in Castellon de la Plana (Spain) within the project "Neumonía Zero". The data were collected during the months of May and June 2012 through direct observation which lasted 33 days. 5 check lists based on international recommendations were used for the objective evaluation on the adoption of preventive treatments. 58 patients in invasive mechanical ventilation and 43 ICU nurses were enrolled. Compliance procedure showed no significant differences among each other with an average adhesion of 78% of the observations. The observations trend shows a tendency of improvement in accordance with the checklists of cuff pressure and of the inclination of the bed head. An incidence rate of VAP 13,37/1000 was observed. In conclusion, direct observation showed good compliance to the protocols used in the ward. The obtained data allows to re-direct educational choices and assume a systematic application of this methodology with an important contribution to nursing.

  5. Stress tensor and focal mechanisms in the Dead Sea basin

    NASA Astrophysics Data System (ADS)

    Hofstetter, A.; Dorbath, C.; Dorbath, L.; Braeuer, B.; Weber, M. H.

    2015-12-01

    We use the recorded seismicity, confined to the Dead Sea basin and its boundaries, by the Dead Sea Integrated Research (DESIRE) portable seismic network and the Israel and Jordan permanent seismic networks for studying the mechanisms of earthquakes that occurred in the Dead Sea basin. The observed seismicity in the Dead Sea basin was divided into 9 regions according to the spatial distribution of the earthquakes and the known tectonic features. The large number of recording stations and the good station distribution allowed the reliable determinations of 494 earthquake focal mechanisms. For each region, based on the inversion of the observed polarities of the earthquakes, we determine the focal mechanisms and the associated stress tensor. For 159 earthquakes out of the 494 mechanisms we could determine compatible fault planes. On the eastern side, the focal mechanisms are mainly strike-slip mechanism with nodal planes in the N-S and E-W directions. The azimuths of the stress axes are well constrained presenting minimal variability in the inversion of the data, which is in good agreement with the Arava fault on the eastern side of the Dead Sea basin and what we had expected from the regional geodynamics. However, larger variabilities of the azimuthal and dip angles are observed on the western side of the basin. Due to the wider range of azimuths of the fault planes, we observe the switching of sigma1 and sigma2 or the switching of sigma2 and sigma3as major horizontal stress directions. This observed switching of stress axes allows having dip-slip and normal mechanisms in a region that is dominated by strike-slip motion.

  6. Advanced Engineering Technology for Measuring Performance.

    PubMed

    Rutherford, Drew N; D'Angelo, Anne-Lise D; Law, Katherine E; Pugh, Carla M

    2015-08-01

    The demand for competency-based assessments in surgical training is growing. Use of advanced engineering technology for clinical skills assessment allows for objective measures of hands-on performance. Clinical performance can be assessed in several ways via quantification of an assessee's hand movements (motion tracking), direction of visual attention (eye tracking), levels of stress (physiologic marker measurements), and location and pressure of palpation (force measurements). Innovations in video recording technology and qualitative analysis tools allow for a combination of observer- and technology-based assessments. Overall the goal is to create better assessments of surgical performance with robust validity evidence. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. The cyber threat landscape: Challenges and future research directions

    NASA Astrophysics Data System (ADS)

    Gil, Santiago; Kott, Alexander; Barabási, Albert-László

    2014-07-01

    While much attention has been paid to the vulnerability of computer networks to node and link failure, there is limited systematic understanding of the factors that determine the likelihood that a node (computer) is compromised. We therefore collect threat log data in a university network to study the patterns of threat activity for individual hosts. We relate this information to the properties of each host as observed through network-wide scans, establishing associations between the network services a host is running and the kinds of threats to which it is susceptible. We propose a methodology to associate services to threats inspired by the tools used in genetics to identify statistical associations between mutations and diseases. The proposed approach allows us to determine probabilities of infection directly from observation, offering an automated high-throughput strategy to develop comprehensive metrics for cyber-security.

  8. Observing the operational significance of discord consumption

    NASA Astrophysics Data System (ADS)

    Gu, Mile; Chrzanowski, Helen M.; Assad, Syed M.; Symul, Thomas; Modi, Kavan; Ralph, Timothy C.; Vedral, Vlatko; Lam, Ping Koy

    2012-09-01

    Coherent interactions that generate negligible entanglement can still exhibit unique quantum behaviour. This observation has motivated a search beyond entanglement for a complete description of all quantum correlations. Quantum discord is a promising candidate. Here, we demonstrate that under certain measurement constraints, discord between bipartite systems can be consumed to encode information that can only be accessed by coherent quantum interactions. The inability to access this information by any other means allows us to use discord to directly quantify this `quantum advantage'. We experimentally encode information within the discordant correlations of two separable Gaussian states. The amount of extra information recovered by coherent interaction is quantified and directly linked with the discord consumed during encoding. No entanglement exists at any point of this experiment. Thus we introduce and demonstrate an operational method to use discord as a physical resource.

  9. Open-access and multi-directional electroosmotic flow chip for positioning heterotypic cells.

    PubMed

    Terao, Kyohei; Kitazawa, Yuko; Yokokawa, Ryuji; Okonogi, Atsuhito; Kotera, Hidetoshi

    2011-04-21

    We propose a novel method of cell positioning using electroosmotic flow (EOF) to analyze cell-cell interactions. The EOF chip has an open-to-air configuration, is equipped with four electrodes to induce multi-directional EOF, and allows access of tools for liquid handling and of physical probes for cell measurements. Evaluation of the flow within this chip indicated that it controlled hydrodynamic transport of cells, in terms of both speed and direction. We also evaluated cell viability after EOF application and determined appropriate conditions for cell positioning. Two cells were successively positioned in pocket-like microstructures, one in each micropocket, by controlling the EOF direction. As an experimental demonstration, we observed contact interactions between two individual cells through gap junction channels. The EOF chip should provide ways to elucidate various cell-cell interactions between heterotypic cells.

  10. Global tracking for a class of uncertain nonlinear systems with unknown sign-switching control direction by output feedback

    NASA Astrophysics Data System (ADS)

    Roux Oliveira, Tiago; Jacoud Peixoto, Alessandro; Hsu, Liu

    2015-09-01

    This paper addresses the design of a sliding mode controller for a class of high-order uncertain nonlinear plants with unmatched state-dependent nonlinearities and unknown sign of the high frequency gain, i.e., the control direction is assumed unknown. Differently from most previous studies, the control direction is allowed to switch its sign. We show that it is possible to obtain global exact tracking using only output-feedback by coupling a relay periodic switching function with a norm state observer. One significant advantage of the new scheme is its robustness and improved transient response under arbitrary changes of the control direction which have been theoretically demonstrated for jump variations and successfully tested by simulations. The proposed controller is also evaluated with a DC motor control experiment.

  11. Isolating and quantifying cross-beam energy transfer in direct-drive implosions on OMEGA and the National Ignition Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Davis, A. K., E-mail: adavi@lle.rochester.edu; Cao, D.; Michel, D. T.

    The angularly resolved mass ablation rates and ablation-front trajectories for Si-coated CH targets were measured in direct-drive inertial confinement fusion experiments to quantify cross-beam energy transfer (CBET) while constraining the hydrodynamic coupling. A polar-direct-drive laser configuration, where the equatorial laser beams were dropped and the polar beams were repointed from a symmetric direct-drive configuration, was used to limit CBET at the pole while allowing it to persist at the equator. The combination of low- and high-CBET conditions observed in the same implosion allowed for the effects of CBET on the ablation rate and ablation pressure to be determined. Hydrodynamic simulationsmore » performed without CBET agreed with the measured ablation rate and ablation-front trajectory at the pole of the target, confirming that the CBET effects on the pole are small. The simulated mass ablation rates and ablation-front trajectories were in excellent agreement with the measurements at all angles when a CBET model based on Randall's equations [C. J. Randall et al., Phys. Fluids 24, 1474 (1981)] was included into the simulations with a multiplier on the CBET gain factor. These measurements were performed on OMEGA and at the National Ignition Facility to access a wide range of plasma conditions, laser intensities, and laser beam geometries. The presence of the CBET gain multiplier required to match the data in all of the configurations tested suggests that additional physics effects, such as intensity variations caused by diffraction, polarization effects, or shortcomings of extending the 1-D Randall model to 3-D, should be explored to explain the differences in observed and predicted drive.« less

  12. Hand disinfection in a neonatal intensive care unit: continuous electronic monitoring over a one-year period.

    PubMed

    Helder, Onno K; van Goudoever, Johannes B; Hop, Wim C J; Brug, Johannes; Kornelisse, René F

    2012-10-08

    Good hand hygiene compliance is essential to prevent nosocomial infections in healthcare settings. Direct observation of hand hygiene compliance is the gold standard but is time consuming. An electronic dispenser with built-in wireless recording equipment allows continuous monitoring of its usage. The purpose of this study was to monitor the use of alcohol-based hand rub dispensers with a built-in electronic counter in a neonatal intensive care unit (NICU) setting and to determine compliance with hand hygiene protocols by direct observation. A one-year observational study was conducted at a 27 bed level III NICU at a university hospital. All healthcare workers employed at the NICU participated in the study. The use of bedside dispensers was continuously monitored and compliance with hand hygiene was determined by random direct observations. A total of 258,436 hand disinfection events were recorded; i.e. a median (interquartile range) of 697 (559-840) per day. The median (interquartile range) number of hand disinfection events performed per healthcare worker during the day, evening, and night shifts was 13.5 (10.8 - 16.7), 19.8 (16.3 - 24.1), and 16.6 (14.2 - 19.3), respectively. In 65.8% of the 1,168 observations of patient contacts requiring hand hygiene, healthcare workers fully complied with the protocol. We conclude that the electronic devices provide useful information on frequency, time, and location of its use, and also reveal trends in hand disinfection events over time. Direct observations offer essential data on compliance with the hand hygiene protocol. In future research, data generated by the electronic devices can be supplementary used to evaluate the effectiveness of hand hygiene promotion campaigns.

  13. Direct Analysis of Textile Fabrics and Dyes Using IR Matrix-Assisted Laser Desorption Electrospray Ionization (MALDESI) Mass Spectrometry

    PubMed Central

    Cochran, Kristin H.; Barry, Jeremy A.; Muddiman, David C.; Hinks, David

    2012-01-01

    The forensic analysis of textile fibers uses a variety of techniques from microscopy to spectroscopy. One such technique that is often used to identify the dye(s) within the fiber is mass spectrometry (MS). In the traditional MS method, the dye must be extracted from the fabric and the dye components are separated by chromatography prior to mass spectrometric analysis. Direct analysis of the dye from the fabric allows the omission of the lengthy sample preparation involved in extraction, thereby significantly reducing the overall analysis time. Herein, a direct analysis of dyed textile fabric was performed using the infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) source for MS. In MALDESI, an IR laser with wavelength tuned to 2.94 μm is used to desorb the dye from the fabric sample with the aid of water as the matrix. The desorbed dye molecules are then post-ionized by electrospray ionization (ESI). A variety of dye classes were analyzed from various fabrics with little to no sample preparation allowing for the identification of the dye mass and in some cases the fiber polymer. Those dyes that were not detected using MALDESI were also not observed by direct infusion ESI of the dye standard. PMID:23237031

  14. DETECTION OF WHITE DWARF COMPANIONS TO BLUE STRAGGLERS IN THE OPEN CLUSTER NGC 188: DIRECT EVIDENCE FOR RECENT MASS TRANSFER

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gosnell, Natalie M.; Mathieu, Robert D.; Geller, Aaron M.

    2014-03-01

    Several possible formation pathways for blue straggler stars have been developed recently, but no one pathway has yet been observationally confirmed for a specific blue straggler. Here we report the first findings from a Hubble Space Telescope Advanced Camera for Surveys/Solar Blind Channel far-UV photometric program to search for white dwarf companions to blue straggler stars. We find three hot and young white dwarf companions to blue straggler stars in the 7 Gyr open cluster NGC 188, indicating that mass transfer in these systems ended less than 300 Myr ago. These companions are direct and secure observational evidence that these blue straggler starsmore » were formed through mass transfer in binary stars. Their existence in a well-studied cluster environment allows for observational constraints of both the current binary system and the progenitor binary system, mapping the entire mass transfer history.« less

  15. Condensation in Nanoporous Packed Beds.

    PubMed

    Ally, Javed; Molla, Shahnawaz; Mostowfi, Farshid

    2016-05-10

    In materials with tiny, nanometer-scale pores, liquid condensation is shifted from the bulk saturation pressure observed at larger scales. This effect is called capillary condensation and can block pores, which has major consequences in hydrocarbon production, as well as in fuel cells, catalysis, and powder adhesion. In this study, high pressure nanofluidic condensation studies are performed using propane and carbon dioxide in a colloidal crystal packed bed. Direct visualization allows the extent of condensation to be observed, as well as inference of the pore geometry from Bragg diffraction. We show experimentally that capillary condensation depends on pore geometry and wettability because these factors determine the shape of the menisci that coalesce when pore filling occurs, contrary to the typical assumption that all pore structures can be modeled as cylindrical and perfectly wetting. We also observe capillary condensation at higher pressures than has been done previously, which is important because many applications involving this phenomenon occur well above atmospheric pressure, and there is little, if any, experimental validation of capillary condensation at such pressures, particularly with direct visualization.

  16. Direct Observations of Clouds on Brown Dwarfs: A Spitzer Study of Extreme Cases

    NASA Astrophysics Data System (ADS)

    Burgasser, Adam; Cruz, Kelle; Cushing, Michael; Kirkpatrick, J. Davy; Looper, Dagny; Lowrance, Patrick; Marley, Mark; Saumon, Didier

    2008-03-01

    Clouds play a fundamental role in the emergent spectral energy distributions and observed variability of very low mass stars and brown dwarfs, yet hey have only been studied indirectly thus far. Recent indications of a broad silicate grain absorption feature in the 8-11 micron spectra of mid-type L dwarfs, and evidence that the strength of this absorption varies according to broad-band near-infrared color, may finally allow the first direct studies of clouds and condensate grain properties in brown dwarf atmospheres. We propose to observe a sample of 18 ``extreme'' L dwarfs - objects with unusually blue and red near-infrared colors - with IRAC and IRS to study the 8-11 micron feature in detail (including grain size distributions and bulk compositions), and to constrain advanced condensate cloud atmosphere models currently in development. Our program provides a unique examination of the general processes of cloud formation by focusing on the relatively warm photospheres of late-type brown dwarfs.

  17. Symmetry breaking and electrical frustration during tip-induced polarization switching in the non-polar cut of lithium niobate single crystals

    DOE PAGES

    Ievlev, Anton; Alikin, Denis O.; Morozovska, A. N.; ...

    2014-12-15

    Polarization switching in ferroelectric materials is governed by a delicate interplay between bulk polarization dynamics and screening processes at surfaces and domain walls. Here we explore the mechanism of tip-induced polarization switching in the non-polar cuts of uniaxial ferroelectrics. In this case, in-plane component of polarization vector switches, allowing for detailed observations of resultant domain morphologies. We observe surprising variability of resultant domain morphologies stemming from fundamental instability of formed charged domain wall and associated electric frustration. In particular, we demonstrate that controlling vertical tip position allows the polarity of the switching to be controlled. This represents very unusual formmore » of symmetry breaking where mechanical motion in vertical direction controls the lateral domain growth. The implication of these studies for ferroelectric devices and domain wall electronics are discussed.« less

  18. Shell model for drag reduction with polymer additives in homogeneous turbulence.

    PubMed

    Benzi, Roberto; De Angelis, Elisabetta; Govindarajan, Rama; Procaccia, Itamar

    2003-07-01

    Recent direct numerical simulations of the finite-extensibility nonlinear elastic dumbbell model with the Peterlin approximation of non-Newtonian hydrodynamics revealed that the phenomenon of drag reduction by polymer additives exists (albeit in reduced form) also in homogeneous turbulence. We use here a simple shell model for homogeneous viscoelastic flows, which recaptures the essential observations of the full simulations. The simplicity of the shell model allows us to offer a transparent explanation of the main observations. It is shown that the mechanism for drag reduction operates mainly on large scales. Understanding the mechanism allows us to predict how the amount of drag reduction depends on the various parameters in the model. The main conclusion is that drag reduction is not a universal phenomenon; it peaks in a window of parameters such as the Reynolds number and the relaxation rate of the polymer.

  19. Intraoperative intravital microscopy permits the study of human tumour vessels

    PubMed Central

    Fisher, Daniel T.; Muhitch, Jason B.; Kim, Minhyung; Doyen, Kurt C.; Bogner, Paul N.; Evans, Sharon S.; Skitzki, Joseph J.

    2016-01-01

    Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravital high-resolution imaging of human tumours in the clinical setting. Here we report the feasibility of IVM examinations of human malignant disease with an emphasis on tumour vasculature as the major site of tumour-host interactions. Consistent with preclinical observations, we show that patient tumour vessels are disorganized, tortuous and ∼50% do not support blood flow. Human tumour vessel diameters are larger than predicted from immunohistochemistry or preclinical IVM, and thereby have lower wall shear stress, which influences delivery of drugs and cellular immunotherapies. Thus, real-time clinical imaging of living human tumours is feasible and allows for detection of characteristics within the tumour microenvironment. PMID:26883450

  20. Fundamental Physics from Observations of White Dwarf Stars

    NASA Astrophysics Data System (ADS)

    Bainbridge, M. B.; Barstow, M. A.; Reindl, N.; Barrow, J. D.; Webb, J. K.; Hu, J.; Preval, S. P.; Holberg, J. B.; Nave, G.; Tchang-Brillet, L.; Ayres, T. R.

    2017-03-01

    Variation in fundamental constants provide an important test of theories of grand unification. Potentially, white dwarf spectra allow us to directly observe variation in fundamental constants at locations of high gravitational potential. We study hot, metal polluted white dwarf stars, combining far-UV spectroscopic observations, atomic physics, atmospheric modelling and fundamental physics, in the search for variation in the fine structure constant. This registers as small but measurable shifts in the observed wavelengths of highly ionized Fe and Ni lines when compared to laboratory wavelengths. Measurements of these shifts were performed by Berengut et al (2013) using high-resolution STIS spectra of G191-B2B, demonstrating the validity of the method. We have extended this work by; (a) using new (high precision) laboratory wavelengths, (b) refining the analysis methodology (incorporating robust techniques from previous studies towards quasars), and (c) enlarging the sample of white dwarf spectra. A successful detection would be the first direct measurement of a gravitational field effect on a bare constant of nature. We describe our approach and present preliminary results.

  1. Observation of ultra high energy cosmic rays from space: Status and perspectives

    NASA Astrophysics Data System (ADS)

    Casolino, M.; Klimov, P.; Piotrowski, L.

    2017-12-01

    The study of ultra high energy cosmic rays (UHECRs) offers unique possibilities to probe the energies currently inaccessible by man-made accelerators. Recent years have shed light on several characteristics of these particles, but—due to their extremely low flux—their origin, nature, and acceleration mechanisms are still unclear. Space-based observations have the potential for an increase in statistics, up to several orders of magnitude, and would be able to cover the whole sky, allowing for a direct comparison of spectra and direction of arrival. A detector with the exposure of a few times that of the Pierre Auger Observatory would be able to clarify the observed differences between the northern and southern skies, confirm the existence of TA hot spot, and measure multipolar anisotropies with high precision. A number of novel technologies—from optics to sensors, front-end and read-out electronics—have been developed over the years to achieve this goal. In this paper we describe the progress and results obtained so far and discuss the perspectives of UHECR physics observation from space.

  2. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated under...

  3. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated under...

  4. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated under...

  5. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated under...

  6. 40 CFR 73.72 - Direct sales.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated under...

  7. New Experimental Results of Simulating Micrometeoroid Ablation in the Laboratory

    NASA Astrophysics Data System (ADS)

    Sternovsky, Zoltan; Thomas, Evan; DeLuca, Michael; Janches, Diego; Munsat, Tobin; Plane, John

    2017-04-01

    A facility is developed to simulate the ablation of micrometeoroids in laboratory conditions, which also allows measuring the ionization probability of the ablated material. An electrostatic dust accelerator is used to generate iron, aluminum and meteoric analog particles with velocities 10-50 km/s. The particles are then introduced into a cell filled with nitrogen, air or carbon dioxide gas with pressures adjustable in the 0.02 - 0.5 Torr range, where the partial or complete ablation of the particle occurs over a short distance. An array of biased electrodes is used to collect the ionized products with spatial resolution along the ablating particles' path, allowing thus the study of the temporal resolution of the process. A new optical observation setup using a 64 channel PMT system was added to the setup to allow the observation of the ablating particle and deceleration of the particle from the neutral drag. A simple ablation model is used to match the observations. For completely ablated particles the total collected charge directly yields the ionization efficiency. The measurements using iron particles in N2 and air are in relatively good agreement with earlier data. The new experimental data using aluminum particles suggest that the neutral drag acting of the particle is smaller than expected.

  8. 3D surface flow kinematics derived from airborne UAVSAR interferometric synthetic aperture radar to constrain the physical mechanisms controlling landslide motion

    NASA Astrophysics Data System (ADS)

    Delbridge, B. G.; Burgmann, R.; Fielding, E. J.; Hensley, S.; Schulz, W. H.

    2013-12-01

    This project focuses on improving our understanding of the physical mechanisms controlling landslide motion by studying the landslide-wide kinematics of the Slumgullion landslide in southwestern Colorado using interferometric synthetic aperture radar (InSAR) and GPS. The NASA/JPL UAVSAR airborne repeat-pass SAR interferometry system imaged the Slumgullion landslide from 4 look directions on eight flights in 2011 and 2012. Combining the four look directions allows us to extract the full 3-D velocity field of the surface. Observing the full 3-dimensional flow field allows us to extract the full strain tensor (assuming free surface boundary conditions and incompressible flow) since we have both the spatial resolution to take spatial derivates and full deformation information. COSMO-SkyMed(CSK) high-resolution Spotlight data was also acquired during time intervals overlapping with the UAVSAR one-week pairs, with intervals as short as one day. These observations allow for the quantitative testing of the deformation magnitude and estimated formal errors in the UAVSAR derived deformation field. We also test the agreement of the deformation at 20 GPS monitoring sites concurrently acquired by the USGS. We also utilize the temporal resolution of real-time GPS acquired by the UC Berkeley Active Tectonics Group during a temporary deployment from July 22nd - August 2nd. By combining this data with the kinematic data we hope to elucidate the response of the landslide to environmental changes such as rainfall, snowmelt, and atmospheric pressure, and consequently the mechanisms controlling the dynamics of the landslide system. To constrain the longer temporal dynamics, interferograms made from pairs of CSK images acquired in 2010, 2011, 2012 and 2013 reveal the slide deformation on a longer timescale by allowing us to measure meters of motion and see the average rates over year long intervals using pixel offset tracking of the high-resolution SAR amplitude images. The results of this study will also allow us to test the agreement and commensurability of UAVSAR- derived deformation with real-time GPS observations and traditional satellite-based SAR interferometry from the COSMOSkyMed system. We will not only help mitigate the hazards associated with large landslides, but also provide information on the limitations of current geodetic imaging techniques. This unique opportunity to compare several concurrent geodetic observations of the same deformation will provide constraints and recommendations for the design and implementation of future geodetic systems for the monitoring of Earth surface processes.

  9. Lg Attenuation Anisotropy Across the Western US

    NASA Astrophysics Data System (ADS)

    Phillips, W. S.; Rowe, C. A.; Stead, R. J.; Begnaud, M. L.

    2017-12-01

    The USArray has allowed us to map seismic attenuation of local and regional phases to unprecedented spatial extent and resolution. Following standard mantle Pn velocity anisotropy methods, we have incorporated azimuthal anisotropy into our tomographic inversion of high-frequency Lg amplitudes. The Lg is a crustal shear phase made up of many trapped modes, thus results can be considered to be crustal averages. Azimuthal anisotropy reduces residual variance by just over 10% for 1.5-3 Hz Lg. We observe a median anisotropic variation of 12%, and a high of 50% in the Salton Trough. Low attenuation (high-Q) directions run parallel to topographic fabric and major strike slip faults in tectonically active areas, and often run parallel to mantle shear wave splitting directions in stable regions. Tradeoffs are of concern, and synthetic tests show that elongated attenuation anomalies will produce anisotropy artifacts, but of factors 2-3 times lower than observations. In particular, the strength of a long, narrow high-Q anomaly will trade off with high-Q directions parallel to the long axis, while an elongated low-Q anomaly will trade off with high-Q directions perpendicular to the long axis. We observe an elongated low-Q anomaly associated with the Walker Lane; however, observed high-Q directions run parallel to the long axis of this anomaly, opposite to the tradeoff effect, supporting the anisotropic observation, and implying that the effect may be underestimated. Further, we observe an elongated high-Q anomaly associated with the Great Valley and Sierra Nevada that runs across the long axis, again opposite to the tradeoff effect. This study was performed using waveforms, event locations and phase picks made available by IRIS, NEIC and ANF, and processing was done using semi-automated means, thus this is a technique that can be applied quickly to study crustal anisotropy over large areas when appropriate station density is available.

  10. A discussion of differences in preparation, performance and postreflections in participant observations within two grounded theory approaches.

    PubMed

    Berthelsen, Connie Bøttcher; Lindhardt, Tove; Frederiksen, Kirsten

    2017-06-01

    This paper presents a discussion of the differences in using participant observation as a data collection method by comparing the classic grounded theory methodology of Barney Glaser with the constructivist grounded theory methodology by Kathy Charmaz. Participant observations allow nursing researchers to experience activities and interactions directly in situ. However, using participant observations as a data collection method can be done in many ways, depending on the chosen grounded theory methodology, and may produce different results. This discussion shows that how the differences between using participant observations in classic and constructivist grounded theory can be considerable and that grounded theory researchers should adhere to the method descriptions of performing participant observations according to the selected grounded theory methodology to enhance the quality of research. © 2016 Nordic College of Caring Science.

  11. Understanding EROS2 observations toward the spiral arms within a classical Galactic model framework

    NASA Astrophysics Data System (ADS)

    Moniez, M.; Sajadian, S.; Karami, M.; Rahvar, S.; Ansari, R.

    2017-08-01

    Aims: EROS (Expérience de Recherche d'Objets Sombres) has searched for microlensing toward four directions in the Galactic plane away from the Galactic center. The interpretation of the catalog optical depth is complicated by the spread of the source distance distribution. We compare the EROS microlensing observations with Galactic models (including the Besançon model), tuned to fit the EROS source catalogs, and take into account all observational data such as the microlensing optical depth, the Einstein crossing durations, and the color and magnitude distributions of the catalogued stars. Methods: We simulated EROS-like source catalogs using the HIgh-Precision PARallax COllecting Satellite (Hipparcos) database, the Galactic mass distribution, and an interstellar extinction table. Taking into account the EROS star detection efficiency, we were able to produce simulated color-magnitude diagrams that fit the observed diagrams. This allows us to estimate average microlensing optical depths and event durations that are directly comparable with the measured values. Results: Both the Besançon model and our Galactic model allow us to fully understand the EROS color-magnitude data. The average optical depths and mean event durations calculated from these models are in reasonable agreement with the observations. Varying the Galactic structure parameters through simulation, we were also able to deduce contraints on the kinematics of the disk, the disk stellar mass function (at a few kpc distance from the Sun), and the maximum contribution of a thick disk of compact objects in the Galactic plane (Mthick< 5 - 7 × 1010M⊙ at 95%, depending on the model). We also show that the microlensing data toward one of our monitored directions are significantly sensitive to the Galactic bar parameters, although much larger statistics are needed to provide competitive constraints. Conclusions: Our simulation gives a better understanding of the lens and source spatial distributions in the microlensing events. The goodness of a global fit taking into account all the observables (from the color-magnitude diagrams and microlensing observations) shows the validity of the Galactic models. Our tests with the parameters excursions show the unique sensitivity of the microlensing data to the kinematical parameters and stellar initial mass function. http://www.lal.in2p3.fr/recherche/eros

  12. Annular gel reactor for chemical pattern formation

    DOEpatents

    Nosticzius, Zoltan; Horsthemke, Werner; McCormick, William D.; Swinney, Harry L.; Tam, Wing Y.

    1990-01-01

    The present invention is directed to an annular gel reactor suitable for the production and observation of spatiotemporal patterns created during a chemical reaction. The apparatus comprises a vessel having at least a first and second chamber separated one from the other by an annular polymer gel layer (or other fine porous medium) which is inert to the materials to be reacted but capable of allowing diffusion of the chemicals into it.

  13. The Seasonal Evolution of Sea Ice Floe Size Distribution

    DTIC Science & Technology

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. “The Seasonal Evolution of Sea Ice Floe Size Distribution... seasonally in the southern Beaufort and Chukchi Seas region. OBJECTIVES The objective of this work was to determine the seasonal evolution of the...summer melt season using (4). The technique allows for the direct observation of lateral melt and the 3 calculation of changes in floe perimeter, and

  14. Measuring and Tracking Skills in the Army Reconnaissance Course

    DTIC Science & Technology

    2018-01-01

    student to directly sign the assessment. Figure 4 displays a screen shot of this feature. Figure 4. Red/green card feature for on -the-spot...Officer’s Representative and Subject Matter POC: Jennifer S. Tucker 14. ABSTRACT This report describes follow- on research to Ratwani, Dean, Knott...includes measures of leader skills/attributes on a tablet allowing instructors to observe and assess classroom and field events in real time. The

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hua, Xin; Yu, Xiao-Ying; Wang, Zhaoying

    The first results of using a novel single channel microfluidic reactor to enable Shewanella biofilm growth and in situ characterization using time-of-flight secondary ion mass spectrometry (ToF-SIMS) in the hydrated environment are presented. The new microfluidic interface allows direct probing of the liquid surface using ToF-SIMS, a vacuum surface technique. The detection window is an aperture of 2 m in diameter on a thin silicon nitride (SiN) membrane and it allows direct detection of the liquid surface. Surface tension of the liquid flowing inside the microchannel holds the liquid within the aperture. ToF-SIMS depth profiling was used to drill throughmore » the SiN membrane and the biofilm grown on the substrate. In situ 2D imaging of the biofilm in hydrated state was acquired, providing spatial distribution of the chemical compounds in the biofilm system. This data was compared with a medium filled microfluidic reactor devoid of biofilm and dried biofilm samples deposited on clean silicon wafers. Principle Component Analysis (PCA) was used to investigate these observations. Our results show that imaging biofilms in the hydrated environment using ToF-SIMS is possible using the unique microfluidic reactor. Moreover, characteristic biofilm fatty acids fragments were observed in the hydrated biofilm grown in the microfluidic channel, illustrating the advantage of imaging biofilm in its native environment.« less

  16. Acoustic propagation and atmosphere characteristics derived from infrasonic waves generated by the Concorde.

    PubMed

    Le, Pichon Alexis; Garcés, Milton; Blanc, Elisabeth; Barthélémy, Maud; Drob, Doug P

    2002-01-01

    Infrasonic signals generated by daily supersonic Concorde flights between North America and Europe have been consistently recorded by an array of microbarographs in France. These signals are used to investigate the effects of atmospheric variability on long-range sound propagation. Statistical analysis of wave parameters shows seasonal and daily variations associated with changes in the wind structure of the atmosphere. The measurements are compared to the predictions obtained by tracing rays through realistic atmospheric models. Theoretical ray paths allow a consistent interpretation of the observed wave parameters. Variations in the reflection level, travel time, azimuth deviation and propagation range are explained by the source and propagation models. The angular deviation of a ray's azimuth direction, due to the seasonal and diurnal fluctuations of the transverse wind component, is found to be approximately 5 degrees from the initial launch direction. One application of the seasonal and diurnal variations of the observed phase parameters is the use of ground measurements to estimate fluctuations in the wind velocity at the reflection heights. The simulations point out that care must be taken when ascribing a phase velocity to a turning height. Ray path simulations which allow the correct computation of reflection heights are essential for accurate phase identifications.

  17. Wave Turning and Flow Angle in the E-Region Ionosphere

    NASA Astrophysics Data System (ADS)

    Young, M.; Oppenheim, M. M.; Dimant, Y. S.

    2016-12-01

    This work presents results of particle-in-cell (PIC) simulations of Farley-Buneman (FB) turbulence at various altitudes in the high-latitude E-region ionosphere. In that region, the FB instability regularly produces meter-scale plasma irregularities. VHF radars observe coherent echoes via Bragg scatter from wave fronts parallel or anti-parallel to the radar line of sight (LoS) but do not necessarily measure the mean direction of wave propagation. Haldoupis (1984) conducted a study of diffuse radar aurora and found that the spectral width of back-scattered power depends critically on the angle between the radar LoS and the true flow direction, called the flow angle. Knowledge of the flow angle will allow researchers to better interpret observations of coherent back-scatter. Experiments designed to observe meter-scale irregularities in the E-region ionosphere created by the FB instability typically assume that the predominant flow direction is the E×B direction. However, linear theory of Dimant and Oppenheim (2004) showed that FB waves should turn away from E×B and particle-in-cell simulations by Oppenheim and Dimant (2013) support the theory. The present study comprises a quantitative analysis of the dependence of back-scattered power, flow velocity, and spectral width as functions of the flow angle. It also demonstrates that the mean direction of meter-scale wave propagation may differ from the E×B direction by tens of degrees. The analysis includes 2-D and 3-D simulations at a range of altitudes in the auroral ionosphere. Comparison between 2-D and 3-D simulations illustrates the relative importance to the irregularity spectrum of a small but finite component in the direction parallel to B. Previous work has shown this small parallel component to be important to turbulent electron heating and nonlinear transport.

  18. Uncertainty relations as Hilbert space geometry

    NASA Technical Reports Server (NTRS)

    Braunstein, Samuel L.

    1994-01-01

    Precision measurements involve the accurate determination of parameters through repeated measurements of identically prepared experimental setups. For many parameters there is a 'natural' choice for the quantum observable which is expected to give optimal information; and from this observable one can construct an Heinsenberg uncertainty principle (HUP) bound on the precision attainable for the parameter. However, the classical statistics of multiple sampling directly gives us tools to construct bounds for the precision available for the parameters of interest (even when no obvious natural quantum observable exists, such as for phase, or time); it is found that these direct bounds are more restrictive than those of the HUP. The implication is that the natural quantum observables typically do not encode the optimal information (even for observables such as position, and momentum); we show how this can be understood simply in terms of the Hilbert space geometry. Another striking feature of these bounds to parameter uncertainty is that for a large enough number of repetitions of the measurements all V quantum states are 'minimum uncertainty' states - not just Gaussian wave-packets. Thus, these bounds tell us what precision is achievable as well as merely what is allowed.

  19. Correlative measurements of the stratospheric aerosols

    NASA Astrophysics Data System (ADS)

    Santer, R.; Brogniez, C.; Herman, M.; Diallo, S.; Ackerman, M.

    1992-12-01

    Joint experiments were organized or available during stratospheric flights of a photopolarimeter, referred to as RADIBAL (radiometer balloon). In May 1984, RADIBAL flew simultaneously with another balloonborne experiment conducted by the Institut d'Aeronomie Spatiale de Belgique (IASB), which provides multiwavelength vertical profiles of the aerosol scattering coefficient. At this time, the El Chichon layer was observable quite directly from mountain sites. A ground-based station set up at Pic du Midi allowed an extensive description of the aerosol optical properties. The IASB and the Pic du Midi observations are consistent with the aerosol properties derived from the RADIBAL measurement analysis.

  20. Probing pre-inflationary anisotropy with directional variations in the gravitational wave background

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Furuya, Yu; Niiyama, Yuki; Sendouda, Yuuiti, E-mail: furuya@tap.st.hirosaki-u.ac.jp, E-mail: niiyama@tap.st.hirosaki-u.ac.jp, E-mail: sendouda@hirosaki-u.ac.jp

    We perform a detailed analysis on a primordial gravitational-wave background amplified during a Kasner-like pre-inflationary phase allowing for general triaxial anisotropies. It is found that the predicted angular distribution map of gravitational-wave intensity on large scales exhibits topologically distinctive patterns according to the degree of the pre-inflationary anisotropy, thereby serving as a potential probe for the pre-inflationary early universe with future all-sky observations of gravitational waves. We also derive an observational limit on the amplitude of such anisotropic gravitational waves from the B -mode polarisation of the cosmic microwave background.

  1. Extracting joint weak values with local, single-particle measurements.

    PubMed

    Resch, K J; Steinberg, A M

    2004-04-02

    Weak measurement is a new technique which allows one to describe the evolution of postselected quantum systems. It appears to be useful for resolving a variety of thorny quantum paradoxes, particularly when used to study properties of pairs of particles. Unfortunately, such nonlocal or joint observables often prove difficult to measure directly in practice (for instance, in optics-a common testing ground for this technique-strong photon-photon interactions would be needed to implement an appropriate von Neumann interaction). Here we derive a general, experimentally feasible, method for extracting these joint weak values from correlations between single-particle observables.

  2. Fundamental parameters of exoplanets and their host stars

    NASA Astrophysics Data System (ADS)

    Coughlin, Jeffrey Langer

    For much of human history we have wondered how our solar system formed, and whether there are any other planets like ours around other stars. Only in the last 20 years have we had direct evidence for the existence of exoplanets, with the number of known exoplanets dramatically increasing in recent years, especially with the success of the Kepler mission. Observations of these systems are becoming increasingly more precise and numerous, thus allowing for detailed studies of their masses, radii, densities, temperatures, and atmospheric compositions. However, one cannot accurately study exoplanets without examining their host stars in equal detail, and understanding what assumptions must be made to calculate planetary parameters from the directly derived observational parameters. In this thesis, I present observations and models of the primary transits and secondary eclipses of transiting exoplanets from both the ground and Kepler in order to better study their physical characteristics and search for additional exoplanets. I then identify, observe, and model new eclipsing binaries to better understand the stellar mass-radius relationship and stellar limb-darkening, compare these observations to the predictions of stellar models, and attempt to define to what extent these fundamental stellar characteristics can impact derived planetary parameters. I also present novel techniques for the direct determination of exoplanet masses and stellar inclinations via multi-wavelength astrometry, the ground-based photometric observation of stars at sub-millimagnitude precision, the reduction of Kepler photometry from pixel-level data, the extraction of radial velocities from spectroscopic observations, and the automatic identification, period analysis, and modeling of eclipsing binaries and transiting planets in large datasets.

  3. Direct Measurement of the Topological Charge in Elliptical Beams Using Diffraction by a Triangular Aperture.

    PubMed

    Melo, Leandro A; Jesus-Silva, Alcenísio J; Chávez-Cerda, Sabino; Ribeiro, Paulo H Souto; Soares, Willamys C

    2018-04-23

    We introduce a simple method to characterize the topological charge associated with the orbital angular momentum of a m-order elliptic light beam. This method consists in the observation of the far field pattern of the beam carrying orbital angular momentum, diffracted from a triangular aperture. We show numerically and experimentally, for Mathieu, Ince-Gaussian, and vortex Hermite-Gaussian beams, that only isosceles triangular apertures allow us to determine in a precise and direct way, the magnitude m of the order and the number and sign of unitary topological charges of isolated vortices inside the core of these beams.

  4. Flow cytometry as a rapid test for detection of penicillin resistance directly in bacterial cells in Enterococcus faecalis and Staphylococcus aureus.

    PubMed

    Jarzembowski, T; Wiśniewska, K; Józwik, A; Bryl, E; Witkowski, J

    2008-08-01

    We studied the usefulness of flow cytometry for detection of penicillin resistance in E. faecalis and S. aureus by direct binding of commercially available fluorescent penicillin, Bocillin FL, to cells obtained from culture. There were significantly lower percentages of fluorescent cells and median and mean fluorescence values per particle in penicillin-resistant than in penicillin-sensitive strains of both species observed. The method allows rapid detection of penicillin resistance in S. aureus and E. faecalis. The results encourage further investigations on the detection of antibiotic resistance in bacteria using flow cytometry.

  5. Background-Limited Infrared-Submillimeter Spectroscopy (BLISS)

    NASA Technical Reports Server (NTRS)

    Bradford, Charles Matt

    2004-01-01

    The bulk of the cosmic far-infrared background light will soon be resolved into its individual sources with Spitzer, Astro-F, Herschel, and submm/mm ground-based cameras. The sources will be dusty galaxies at z approximately equal to 1-4. Their physical conditions and processes in these galaxies are directly probed with moderate-resolution spectroscopy from 20 micrometers to 1 mm. Currently large cold telescopes are being combined with sensitive direct detectors, offering the potential for mid-far-IR spectroscopy at the background limit (BLISS). The capability will allow routine observations of even modest high-redshift galaxies in a variety of lines. The BLISS instrument's capabilities are described in this presentation.

  6. Direct-to-consumer advertising affects provider / patient relationship.

    PubMed

    1998-12-01

    Family planning program clients are increasingly seeking oral contraceptive pills by brand name. Direct-to-consumer ads have spurred this recent increase in brand-specific requests for prescription drugs. While print consumer pitches for prescription drugs have been around for a long time, proposed guidance issued by the US Food and Drug Administration (FDA) in August 1997 allows pharmaceutical companies to more easily broadcast product claim commercials on television and radio. Now, half of all direct-to-consumer advertising dollars spent by pharmaceutical companies during January-February 1998 were directed to television ads, almost twice the share spent upon television last year. Last year, pharmaceutical companies spent more than $1 billion on direct-to-consumer advertising. The effects of this new policy are presenting in providers' offices. Before the FDA guidance, 41% of physicians participating in a national survey observed an increase in patients' requests for brand name drugs. However, since the change, 65% surveyed to date have observed an increase in such requests. With the increase in advertising comes a potential for violations of the US Food, Drug, and Cosmetic Act, which regulates provider and consumer prescription drug advertising. 125 companies were cited for violations in 1998, 6 specifically for violations connected with contraceptive information they disseminated.

  7. Analysis of physical parameters related with water infiltration in tropical soils located in edges forest in urban areas

    NASA Astrophysics Data System (ADS)

    Márcia Longo, Regina; Cunha, Jessica C. M.; Lammoglia, Rafaella; Mendes, Deborah R.; Mungilioli, Sarah S.; Damame, Desiree B.; Demamboro, Antônio C.; Bettine, Sueli C.; Ribeiro, Admilson I.; Fengler, Felipe H.

    2015-04-01

    A very important factor for water infiltration into the soil in urban forest systems and suffering constant anthropogenic pressures is the analysis of soil compaction where these forests are or will be established. In this context, this work aimed to promote studies on physical parameters related to distribution of pores, compaction and soil biological activity in forest remnants border areas located in urban watersheds in Campinas / SP - Brazil. The Forest of Santa Genebra (22°49'45 "S and 47°06'33" W) has an average altitude of 680m and tropical climate of altitude, has an area of 251 ha and a nine kilometer perimeter. It constitutes 85% of Semideciduos forests and 15% swamp forest. Due to its location close to urban centers, roads and agricultural areas under direct influence of the anthropic means. For the present study analyzes were performed: particle size, soil density, porosity, matters organic, of biopores, and root distribution (primary, secondary and tertiary) and seedlings in 40 points on the perimeter of the forest equidistant 200m remaining edge. The analysis of the results allowed us to observe that areas suffer direct influence of human activities surrounding. With the results set correlations between the different parameters in order to allow a better understanding of the dynamics of water infiltration into the soil under these conditions and the quantity of tertiary roots, biopores and soil density were the best indicator of environmental quality as suffer direct influence of the surrounding areas, especially those near the most urbanized regions. In general, it can be observed that human activities such as deforestation and vehicle traffic, animals and people, promoted soil compaction and consequent changes in water infiltration into the soil in areas of edges of this remnant of these consequences affect direct numerous parameters that directly influence the dynamics of an ecosystem restoration that is now significantly affected by the occupation of their surroundings.

  8. Long-duration planar direct-drive hydrodynamics experiments on the NIF

    NASA Astrophysics Data System (ADS)

    Casner, A.; Mailliet, C.; Khan, S. F.; Martinez, D.; Izumi, N.; Kalantar, D.; Di Nicola, P.; Di Nicola, J. M.; Le Bel, E.; Igumenshchev, I.; Tikhonchuk, V. T.; Remington, B. A.; Masse, L.; Smalyuk, V. A.

    2018-01-01

    The advent of high-power lasers facilities such as the National Ignition Facility (NIF) and the laser megajoule provide unique platforms to study the physics of turbulent mixing flows in high energy density plasmas. We report here on the commissioning of a novel planar direct-drive platform on the NIF, which allows the acceleration of targets during 30 ns. Planar plastic samples were directly irradiated by 300-450 kJ of UV laser light (351 nm) and a very good planarity of the laser drive is demonstrated. No detrimental effect of imprint is observed in the case of these thick plastic targets (300 μm), which is beneficial for future academic experiments requesting similar irradiation conditions. The long-duration direct-drive (DD) platform is thereafter harnessed to study the ablative Rayleigh-Taylor instability (RTI) in DD. The growth of two-dimensional pre-imposed perturbations is quantified through time-resolved face-on x-ray radiography and used as a benchmark for radiative hydrocode simulations. The ablative RTI is then quantified in its highly nonlinear stage starting from intentionally large 3D imprinted broadband modulations. Two generations of bubble mergers is observed for the first time in DD, as a result of the unprecedented long laser acceleration.

  9. Electronic compressibility of bilayer graphene

    NASA Astrophysics Data System (ADS)

    Henriksen, Erik

    2011-03-01

    We have recently measured the electronic compressibility of bilayer graphene, allowing exploration of the thermodynamic density of states as a function of applied electric and magnetic fields. Utilizing dual-gated field-effect devices, we can independently vary both the carrier density and the size of the tunable band gap. An oscillating voltage applied to a back gate generates corresponding signals in the top gate via electric fields lines which penetrate the graphene, thereby allowing a direct measurement of the inverse compressibility, K-1 , of the bilayer. We have mapped K-1 , which is proportional to the inverse density of states, as a function of the top and back gate voltages in zero and finite magnetic field. A sharp increase in K-1 near zero density is observed with increasing electric field strength, signaling the controlled opening of a band gap. At high magnetic fields, broad Landau level (LL) oscillations are observed, directly revealing the doubled degeneracy of the lowest LL and allowing for a determination of the disorder broadening of the levels. We compare our results to tight-binding calculations of the bilayer band structure, and to recent theoretical studies of the compressibility of bilayer graphene. Together, these clearly illustrate the unusual hyperbolic nature of the low energy band structure, reveal a sizeable electron-hole asymmetry, and suggest that many-body interactions play only a small role in bilayer-on-substrate devices. This work is a collaboration with J. P. Eisenstein of Caltech, and is supported by the NSF under Grant No. DMR-0552270 and the DOE under Grant No. DE-FG03-99ER45766.

  10. Mapping the plateau of novices in virtual reality simulation training of mastoidectomy.

    PubMed

    Andersen, Steven A W; Konge, Lars; Mikkelsen, Peter Trier; Cayé-Thomasen, Per; Sørensen, Mads Sølvsten

    2017-04-01

    To explore why novices' performance plateau in directed, self-regulated virtual reality (VR) simulation training and how performance can be improved. Prospective study. Data on the performances of 40 novices who had completed repeated, directed, self-regulated VR simulation training of mastoidectomy were included. Data were analyzed to identify key areas of difficulty as well as the procedures terminated without using all the time allowed. Novices had difficulty in avoiding drilling holes in the outer anatomical boundaries of the mastoidectomy and frequently made injuries to vital structures such as the lateral semicircular canal, the ossicles, and the facial nerve. The simulator-integrated tutor function improved performance on many of these items, but overreliance on tutoring was observed. Novices also demonstrated poor self-assessment skills and often did not make use of the allowed time, lacking knowledge on when to stop or how to excel. Directed, self-regulated VR simulation training of mastoidectomy needs a strong instructional design with specific process goals to support deliberate practice because cognitive effort is needed for novices to improve beyond an initial plateau. N/A. Laryngoscope, 127:907-914, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  11. Direct terrestrial test of Lorentz symmetry in electrodynamics to 10-18

    NASA Astrophysics Data System (ADS)

    Nagel, Moritz; Parker, Stephen R.; Kovalchuk, Evgeny V.; Stanwix, Paul L.; Hartnett, John G.; Ivanov, Eugene N.; Peters, Achim; Tobar, Michael E.

    2015-09-01

    Lorentz symmetry is a foundational property of modern physics, underlying the standard model of particles and general relativity. It is anticipated that these two theories are low-energy approximations of a single theory that is unified and consistent at the Planck scale. Many unifying proposals allow Lorentz symmetry to be broken, with observable effects appearing at Planck-suppressed levels; thus, precision tests of Lorentz invariance are needed to assess and guide theoretical efforts. Here we use ultrastable oscillator frequency sources to perform a modern Michelson-Morley experiment and make the most precise direct terrestrial test to date of Lorentz symmetry for the photon, constraining Lorentz violating orientation-dependent relative frequency changes Δν/ν to 9.2+/-10.7 × 10-19 (95% confidence interval). This order of magnitude improvement over previous Michelson-Morley experiments allows us to set comprehensive simultaneous bounds on nine boost and rotation anisotropies of the speed of light, finding no significant violations of Lorentz symmetry.

  12. Direct to consumer advertising in pharmaceutical markets.

    PubMed

    Brekke, Kurt R; Kuhn, Michael

    2006-01-01

    We study effects of direct-to-consumer advertising (DTCA) in the prescription drug market. There are two pharmaceutical firms providing horizontally differentiated (branded) drugs. Patients differ in their susceptibility to the drugs. If DTCA is allowed, this can be employed to induce (additional) patient visits. Physicians perfectly observe the patients' type (of illness), but rely on information to prescribe the correct drug. Drug information is conveyed by marketing (detailing), creating a captive and a selective segment of physicians. First, we show that detailing, DTCA and price (if not regulated) are complementary strategies for the firms. Thus, allowing DTCA induces more detailing and higher prices. Second, firms benefit from DTCA if detailing competition is not too fierce, which is true if investing in detailing is sufficiently costly. Otherwise, firms are better off with a ban on DTCA. Finally, DTCA tends to lower welfare if insurance is generous (low copayments) and/or price regulation is lenient. The desirability of DTCA also depends on whether or not the regulator is concerned with firms' profit.

  13. Assessing the Two-Plasmon Decay Threat Through Simulations and Experiments on the NIKE Laser System

    NASA Astrophysics Data System (ADS)

    Phillips, Lee; Weaver, J. L.; Oh, J.; Schmitt, A. J.; Obenschain, S.

    2010-11-01

    NIKE is a Krf laser system at the Naval Research Laboratory used to explore hydrodynamic stability, equation of state, and other physics problems arising in IFE research. The comparatively short KrF wavelength is expected to raise the threshold of most parametric instabilities. We report on simulations performed using the FAST3d radiation hydrocode to design TPD experiments that have have allowed us to explore the validity of simple threshold formulas and help establish the accuracy of our simulations. We have also studied proposed high-gain shock ignition designs and devised experiments that can approach the relevant scalelength-temperature regime, allowing us a potential experimental method to study the LPI threat to these designs by direct observation. Through FAST3d studies of shock-ignited and conventional direct-drive designs with KrF (248 nm) and 3rd harmonic (351nm) drivers, we examine the benefits of the shorter wavelength KrF light in reducing the LPI threat.

  14. Fluorescent image tracking velocimeter

    DOEpatents

    Shaffer, Franklin D.

    1994-01-01

    A multiple-exposure fluorescent image tracking velocimeter (FITV) detects and measures the motion (trajectory, direction and velocity) of small particles close to light scattering surfaces. The small particles may follow the motion of a carrier medium such as a liquid, gas or multi-phase mixture, allowing the motion of the carrier medium to be observed, measured and recorded. The main components of the FITV include: (1) fluorescent particles; (2) a pulsed fluorescent excitation laser source; (3) an imaging camera; and (4) an image analyzer. FITV uses fluorescing particles excited by visible laser light to enhance particle image detectability near light scattering surfaces. The excitation laser light is filtered out before reaching the imaging camera allowing the fluoresced wavelengths emitted by the particles to be detected and recorded by the camera. FITV employs multiple exposures of a single camera image by pulsing the excitation laser light for producing a series of images of each particle along its trajectory. The time-lapsed image may be used to determine trajectory and velocity and the exposures may be coded to derive directional information.

  15. Observation of Compressible Plasma Mix in Cylindrically Convergent Implosions

    NASA Astrophysics Data System (ADS)

    Barnes, Cris W.; Batha, Steven H.; Lanier, Nicholas E.; Magelssen, Glenn R.; Tubbs, David L.; Dunne, A. M.; Rothman, Steven R.; Youngs, David L.

    2000-10-01

    An understanding of hydrodynamic mix in convergent geometry will be of key importance in the development of a robust ignition/burn capability on NIF, LMJ and future pulsed power machines. We have made use of the OMEGA laser facility at the University of Rochester to investigate directly the mix evolution in a convergent geometry, compressible plasma regime. The experiments comprise a plastic cylindrical shell imploded by direct laser irradiation. The cylindrical shell surrounds a lower density plastic foam which provides sufficient back pressure to allow the implosion to stagnate at a sufficiently high radius to permit quantitative radiographic diagnosis of the interface evolution near turnaround. The susceptibility to mix of the shell-foam interface is varied by choosing different density material for the inner shell surface (thus varying the Atwood number). This allows the study of shock-induced Richtmyer-Meshkov growth during the coasting phase, and Rayleigh-Taylor growth during the stagnation phase. The experimental results will be described along with calculational predictions using various radiation hydrodynamics codes and turbulent mix models.

  16. Molecular and kinetic determinants of local anaesthetic action on sodium channels.

    PubMed

    French, R J; Zamponi, G W; Sierralta, I E

    1998-11-23

    (1) Local anaesthetics (LA) rely for their clinical actions on state-dependent inhibition of voltage-dependent sodium channels. (2) Single, batrachoxin-modified sodium channels in planar lipid bilayers allow direct observation of drug-channel interactions. Two modes of inhibition of single-channel current are observed: fast block of the open channels and prolongation of a long-lived closed state, some of whose properties resemble those of the inactivated state of unmodified channels. (3) Analogues of different parts of the LA molecule separately mimic each blocking mode: amines--fast block, and water-soluble aromatics--closed state prolongation. (4) Interaction between a mu-conotoxin derivative and diethylammonium indicate an intrapore site of fast, open-state block. (5) Site-directed mutagenesis studies suggest that hydrophobic residues in transmembrane segment 6 of repeat domain 4 of sodium channels are critical for both LA binding and stabilization of the inactivated state.

  17. Exciton-dominant electroluminescence from a diode of monolayer MoS{sub 2}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ye, Yu; Ye, Ziliang; Gharghi, Majid

    2014-05-12

    In two-dimensional monolayer MoS{sub 2}, excitons dominate the absorption and emission properties. However, the low electroluminescent efficiency and signal-to-noise ratio limit our understanding of the excitonic behavior of electroluminescence. Here, we study the microscopic origin of the electroluminescence from a diode of monolayer MoS{sub 2} fabricated on a heavily p-type doped silicon substrate. Direct and bound-exciton related recombination processes are identified from the electroluminescence. At a high electron-hole pair injection rate, Auger recombination of the exciton-exciton annihilation of the bound exciton emission is observed at room temperature. Moreover, the efficient electrical injection demonstrated here allows for the observation of amore » higher energy exciton peak of 2.255 eV in the monolayer MoS{sub 2} diode, attributed to the excited exciton state of a direct-exciton transition.« less

  18. Compositional and textural information from the dual inversion of visible, near and thermal infrared remotely sensed data

    NASA Technical Reports Server (NTRS)

    Brackett, Robert A.; Arvidson, Raymond E.

    1993-01-01

    A technique is presented that allows extraction of compositional and textural information from visible, near and thermal infrared remotely sensed data. Using a library of both emissivity and reflectance spectra, endmember abundances and endmember thermal inertias are extracted from AVIRIS (Airborne Visible and Infrared Imaging Spectrometer) and TIMS (Thermal Infrared Mapping Spectrometer) data over Lunar Crater Volcanic Field, Nevada, using a dual inversion. The inversion technique is motivated by upcoming Mars Observer data and the need for separation of composition and texture parameters from sub pixel mixtures of bedrock and dust. The model employed offers the opportunity to extract compositional and textural information for a variety of endmembers within a given pixel. Geologic inferences concerning grain size, abundance, and source of endmembers can be made directly from the inverted data. These parameters are of direct relevance to Mars exploration, both for Mars Observer and for follow-on missions.

  19. Transparent metal model study of the use of a cellular growth front to form aligned monotectic composite materials

    NASA Technical Reports Server (NTRS)

    Kaukler, William F.

    1988-01-01

    The purpose of this work was to resolve a scientific controversy in the understanding of how second phase particles become aligned during unidirectional growth of a monotectic alloy. A second aspect was to make the first systematic observations of the solidification behavior of a monotectic alloy during cellular growth in-situ. This research provides the first systematic transparent model study of cellular solidification. An interface stability diagram was developed for the planar to cellular transition of the succinonitrile glycerol (SNG) system. A method was developed utilizing Fourier Transform Infrared Spectroscopy which allows quantitative compositional analysis of directionally solidified SNG along the growth axis. To determine the influence of cellular growth front on alignment for directionally solidified monotectic alloys, the planar and cellular growth morphology was observed in-situ for SNG between 8 and 17 percent glycerol and for a range of over two orders of magnitude G/R.

  20. Gauge-free gyrokinetic theory

    NASA Astrophysics Data System (ADS)

    Burby, Joshua; Brizard, Alain

    2017-10-01

    Test-particle gyrocenter equations of motion play an essential role in the diagnosis of turbulent strongly-magnetized plasmas, and are playing an increasingly-important role in the formulation of kinetic-gyrokinetic hybrid models. Previous gyrocenter models required the knowledge of the perturbed electromagnetic potentials, which are not directly observable quantities (since they are gauge-dependent). A new gauge-free formulation of gyrocenter motion is presented, which enables gyrocenter trajectories to be determined using only measured values of the directly-observable electromagnetic field. Our gauge-free gyrokinetic theory is general enough to allow for gyroradius-scale fluctuations in both the electric and magnetic field. In addition, we provide gauge-free expressions for the charge and current densities produced by a distribution of gyrocenters, which explicitly include guiding-center and gyrocenter polarization and magnetization effects. This research was supported by the U.S. DOE Contract Nos. DE-SC0014032 (AB) and DE-AC05-06OR23100 (JB).

  1. Order parameter fluctuations at a buried quantum critical point

    PubMed Central

    Feng, Yejun; Wang, Jiyang; Jaramillo, R.; van Wezel, Jasper; Haravifard, S.; Srajer, G.; Liu, Y.; Xu, Z.-A.; Littlewood, P. B.; Rosenbaum, T. F.

    2012-01-01

    Quantum criticality is a central concept in condensed matter physics, but the direct observation of quantum critical fluctuations has remained elusive. Here we present an X-ray diffraction study of the charge density wave (CDW) in 2H-NbSe2 at high pressure and low temperature, where we observe a broad regime of order parameter fluctuations that are controlled by proximity to a quantum critical point. X-rays can track the CDW despite the fact that the quantum critical regime is shrouded inside a superconducting phase; and in contrast to transport probes, allow direct measurement of the critical fluctuations of the charge order. Concurrent measurements of the crystal lattice point to a critical transition that is continuous in nature. Our results confirm the long-standing expectations of enhanced quantum fluctuations in low-dimensional systems, and may help to constrain theories of the quantum critical Fermi surface. PMID:22529348

  2. Optical diode effect at spin-wave excitations in the room-temperature multiferroic BiFeO 3.

    DOE PAGES

    Kezsmarki, I.; Nagel, U.; Bordacs, S.; ...

    2015-09-15

    The ability to read and write a magnetic state current-free by an electric voltage would provide a huge technological advantage. Dynamic or optical ME effects are equally interesting, because they give rise to unidirectional light propagation as recently observed in low-temperature multiferroics. This phenomenon, if realized at room temperature, would allow the development of optical diodes which transmit unpolarized light in one, but not in the opposite, direction. Here, we report strong unidirectional transmission in the room-temperature multiferroic BiFeO 3 over the gigahertz-terahertz frequency range. The supporting theory attributes the observed unidirectional transmission to the spin-current-driven dynamic ME effect. Ourmore » findings are an important step toward the realization of optical diodes, supplemented by the ability to switch the transmission direction with a magnetic or electric field.« less

  3. Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory

    NASA Astrophysics Data System (ADS)

    Pierre Auger Collaboration; Abreu, P.; Aglietta, M.; Ahn, E. J.; Albuquerque, I. F. M.; Allard, D.; Allekotte, I.; Allen, J.; Allison, P.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Antičić, T.; Anzalone, A.; Aramo, C.; Arganda, E.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Bäcker, T.; Balzer, M.; Barber, K. B.; Barbosa, A. F.; Bardenet, R.; Barroso, S. L. C.; Baughman, B.; Bäuml, J.; Beatty, J. J.; Becker, B. R.; Becker, K. H.; Bellétoile, A.; Bellido, J. A.; BenZvi, S.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brogueira, P.; Brown, W. C.; Bruijn, R.; Buchholz, P.; Bueno, A.; Burton, R. E.; Caballero-Mora, K. S.; Caramete, L.; Caruso, R.; Castellina, A.; Catalano, O.; Cataldi, G.; Cazon, L.; Cester, R.; Chauvin, J.; Cheng, S. H.; Chiavassa, A.; Chinellato, J. A.; Chou, A.; Chudoba, J.; Clay, R. W.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cook, H.; Cooper, M. J.; Coppens, J.; Cordier, A.; Cotti, U.; Coutu, S.; Covault, C. E.; Creusot, A.; Criss, A.; Cronin, J.; Curutiu, A.; Dagoret-Campagne, S.; Dallier, R.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; De Domenico, M.; De Donato, C.; de Jong, S. J.; De La Vega, G.; de Mello Junior, W. J. M.; de Mello Neto, J. R. T.; De Mitri, I.; de Souza, V.; de Vries, K. D.; Decerprit, G.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; dos Anjos, J. C.; Dova, M. T.; D'Urso, D.; Dutan, I.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Etchegoyen, A.; Facal San Luis, P.; Fajardo Tapia, I.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Ferrero, A.; Fick, B.; Filevich, A.; Filipčič, A.; Fliescher, S.; Fracchiolla, C. E.; Fraenkel, E. D.; Fröhlich, U.; Fuchs, B.; Gaior, R.; Gamarra, R. F.; Gambetta, S.; García, B.; García Gámez, D.; Garcia-Pinto, D.; Gascon, A.; Gemmeke, H.; Gesterling, K.; Ghia, P. L.; Giaccari, U.; Giller, M.; Glass, H.; Gold, M. S.; Golup, G.; Gomez Albarracin, F.; Gómez Berisso, M.; Gonçalves, P.; Gonzalez, D.; Gonzalez, J. G.; Gookin, B.; Góra, D.; Gorgi, A.; Gouffon, P.; Gozzini, S. R.; Grashorn, E.; Grebe, S.; Griffith, N.; Grigat, M.; Grillo, A. F.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Guzman, A.; Hague, J. D.; Hansen, P.; Harari, D.; Harmsma, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hojvat, C.; Hollon, N.; Holmes, V. C.; Homola, P.; Hörandel, J. R.; Horneffer, A.; Hrabovský, M.; Huege, T.; Insolia, A.; Ionita, F.; Italiano, A.; Jarne, C.; Jiraskova, S.; Kadija, K.; Kampert, K. H.; Karhan, P.; Kasper, P.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kelley, J. L.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapp, J.; Koang, D.-H.; Kotera, K.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuehn, F.; Kuempel, D.; Kulbartz, J. K.; Kunka, N.; La Rosa, G.; Lachaud, C.; Lautridou, P.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Lemiere, A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Aüera, A.; Louedec, K.; Lozano Bahilo, J.; Lucero, A.; Ludwig, M.; Lyberis, H.; Maccarone, M. C.; Macolino, C.; Maldera, S.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, J.; Marin, V.; Maris, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurizio, D.; Mazur, P. O.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Mertsch, P.; Meurer, C.; Mićanović, S.; Micheletti, M. I.; Miller, W.; Miramonti, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, E.; Moreno, J. C.; Morris, C.; Mostafá, M.; Moura, C. A.; Mueller, S.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Nhung, P. T.; Niemietz, L.; Nierstenhoefer, N.; Nitz, D.; Nosek, D.; Nožka, L.; Nyklicek, M.; Oehlschläger, J.; Olinto, A.; Oliva, P.; Olmos-Gilbaja, V. M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parizot, E.; Parra, A.; Parsons, R. D.; Pastor, S.; Paul, T.; Pech, M.; Pȩkala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrinca, P.; Petrolini, A.; Petrov, Y.; Petrovic, J.; Pfendner, C.; Phan, N.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Ponce, V. H.; Pontz, M.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rivera, H.; Rizi, V.; Roberts, J.; Robledo, C.; Rodrigues de Carvalho, W.; Rodriguez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodriguez-Cabo, I.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-d'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Rühle, C.; Salamida, F.; Salazar, H.; Salina, G.; Sánchez, F.; Santander, M.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarkar, S.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Schmidt, F.; Schmidt, T.; Scholten, O.; Schoorlemmer, H.; Schovancova, J.; Schovánek, P.; Schöder, F.; Schulte, S.; Schuster, D.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Silva Lopez, H. H.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Stapleton, J.; Stasielak, J.; Stephan, M.; Strazzeri, E.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Tamashiro, A.; Tapia, A.; Tartare, M.; Taşcąu, O.; Tavera Ruiz, C. G.; Tcaciuc, R.; Tegolo, D.; Thao, N. T.; Thomas, D.; Tiffenberg, J.; Timmermans, C.; Tiwari, D. K.; Tkaczyk, W.; Todero Peixoto, C. J.; Tomé, B.; Tonachini, A.; Travnicek, P.; Tridapalli, D. B.; Tristram, G.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van den Berg, A. M.; Varela, E.; Vargas Cáardenas, B.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Warner, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Westerhoff, S.; Whelan, B. J.; Wieczorek, G.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Winders, L.; Winnick, M. G.; Wommer, M.; Wundheiler, B.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Ziolkowski, M.

    2011-06-01

    The Pierre Auger Collaboration has reported evidence for anisotropy in the distribution of arrival directions of the cosmic rays with energies E > Eth = 5.5 × 1019 eV. These show a correlation with the distribution of nearby extragalactic objects, including an apparent excess around the direction of Centaurus A. If the particles responsible for these excesses at E > Eth are heavy nuclei with charge Z, the proton component of the sources should lead to excesses in the same regions at energies E/Z. We here report the lack of anisotropies in these directions at energies above Eth/Z (for illustrative values of Z = 6,13,26). If the anisotropies above Eth are due to nuclei with charge Z, and under reasonable assumptions about the acceleration process, these observations imply stringent constraints on the allowed proton fraction at the lower energies.

  4. (001) 3C SiC/Ni contact interface: In situ XPS observation of annealing induced Ni2Si formation and the resulting barrier height changes

    NASA Astrophysics Data System (ADS)

    Tengeler, Sven; Kaiser, Bernhard; Chaussende, Didier; Jaegermann, Wolfram

    2017-04-01

    The electronic states of the (001) 3C SiC/Ni interface prior and post annealing are investigated via an in situ XPS interface experiment, allowing direct observation of the induced band bending and the transformation from Schottky to ohmic behaviour for the first time. A single domain (001) 3C SiC sample was prepared via wet chemical etching. Nickel was deposited on the sample in multiple in situ deposition steps via RF sputtering, allowing observation of the 3C SiC/Ni interface formation. Over the course of the experiments, an upward band bending of 0.35 eV was observed, along with defect induced Fermi level pinning. This indicates a Schottky type contact behaviour with a barrier height of 0.41 eV. The subsequent annealing at 850 °C for 5 min resulted in the formation of a Ni2Si layer and a reversal of the band bending to 0.06 eV downward. Thus explaining the ohmic contact behaviour frequently reported for annealed n-type 3C SiC/Ni contacts.

  5. L'Astronomia del Venerdí Santo, l'eclissi di Luna e l'ora della Sindone

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    Dating the crucifixion on friday 3 April 33, when, at sunset a partially eclipsed Moon rised allows to interprete the speech of Saint Peter (Acts 2:20=Joel 3:4) on the day of Pentecost as including an account of this eclipse, as fulfillment of the Scriptures. Few minutes later the apparition of a third star of medium magnitude stated the beginning of the sabbatical rest: before that time Jesus has been buried, wrapped into the shroud. The observations of the equinoctial moonrise from the Mount of Olives on September 2013 are strongly in favour of the hypotehsis of possible observation of the lunar eclipse of 33 AD by Jewish people, as well as the sunrises observed from the Temple Institute terrace in Southern-East Jerusalem demonstrated that this eclipse could have been seen from Jerusalem. The depression of the horizon and the refraction allow to see Sun and Moon more than 1 degree below the geometrical horizon in the azimuthal direction ranging from 90 to 116, prologing to 16 minutes the duration of the partial lunar eclipse observed in 33AD. Texts of Matthew, Mark and Cyrillus of Jerusalem are also commented.

  6. Aerosol Direct Radiative Effects and Heating in the New Era of Active Satellite Observations

    NASA Astrophysics Data System (ADS)

    Matus, Alexander V.

    Atmospheric aerosols impact the global energy budget by scattering and absorbing solar radiation. Despite their impacts, aerosols remain a significant source of uncertainty in our ability to predict future climate. Multi-sensor observations from the A-Train satellite constellation provide valuable observational constraints necessary to reduce uncertainties in model simulations of aerosol direct effects. This study will discuss recent efforts to quantify aerosol direct effects globally and regionally using CloudSat's radiative fluxes and heating rates product. Improving upon previous techniques, this approach leverages the capability of CloudSat and CALIPSO to retrieve vertically resolved estimates of cloud and aerosol properties critical for accurately evaluating the radiative impacts of aerosols. We estimate the global annual mean aerosol direct effect to be -1.9 +/- 0.6 W/m2, which is in better agreement with previously published estimates from global models than previous satellite-based estimates. Detailed comparisons against a fully coupled simulation of the Community Earth System Model, however, reveal that this agreement on the global annual mean masks large regional discrepancies between modeled and observed estimates of aerosol direct effects related to model biases in cloud cover. A low bias in stratocumulus cloud cover over the southeastern Pacific Ocean, for example, leads to an overestimate of the radiative effects of marine aerosols. Stratocumulus clouds over the southeastern Atlantic Ocean can enhance aerosol absorption by 50% allowing aerosol layers to remain self-lofted in an area of subsidence. Aerosol heating is found to peak at 0.6 +/- 0.3 K/day an altitude of 4 km in September when biomass burning reaches a maximum. Finally, the contributions of observed aerosols components are evaluated to estimate the direct radiative forcing of anthropogenic aerosols. Aerosol forcing is computed using satellite-based radiative kernels that describe the sensitivity of shortwave fluxes in response to aerosol optical depth. The direct radiative forcing is estimated to be -0.21 W/m2 with the largest contributions from pollution that is partially offset by a positive forcing from smoke aerosols. The results from these analyses provide new benchmarks on the global radiative effects of aerosols and offer new insights for improving future assessments.

  7. Participant Direction for People with Intellectual and Developmental Disabilities in Medicaid Home and Community Based Services Waivers

    ERIC Educational Resources Information Center

    Friedman, Carli

    2018-01-01

    Participant direction allows people with intellectual and developmental disabilities (IDD) and/or their families to direct services; in doing so, participant direction shifts participants from passive recipients to active consumers. Medicaid encourages, but does not require, states to allow participant direction. The aim of this study was to…

  8. A Novel Patient Recruitment Strategy: Patient Selection Directly from the Community through Linkage to Clinical Data.

    PubMed

    Zimmerman, Lindsay P; Goel, Satyender; Sathar, Shazia; Gladfelter, Charon E; Onate, Alejandra; Kane, Lindsey L; Sital, Shelly; Phua, Jasmin; Davis, Paris; Margellos-Anast, Helen; Meltzer, David O; Polonsky, Tamar S; Shah, Raj C; Trick, William E; Ahmad, Faraz S; Kho, Abel N

    2018-01-01

    This article presents and describes our methods in developing a novel strategy for recruitment of underrepresented, community-based participants, for pragmatic research studies leveraging routinely collected electronic health record (EHR) data. We designed a new approach for recruiting eligible patients from the community, while also leveraging affiliated health systems to extract clinical data for community participants. The strategy involves methods for data collection, linkage, and tracking. In this workflow, potential participants are identified in the community and surveyed regarding eligibility. These data are then encrypted and deidentified via a hashing algorithm for linkage of the community participant back to a record at a clinical site. The linkage allows for eligibility verification and automated follow-up. Longitudinal data are collected by querying the EHR data and surveying the community participant directly. We discuss this strategy within the context of two national research projects, a clinical trial and an observational cohort study. The community-based recruitment strategy is a novel, low-touch, clinical trial enrollment method to engage a diverse set of participants. Direct outreach to community participants, while utilizing EHR data for clinical information and follow-up, allows for efficient recruitment and follow-up strategies. This new strategy for recruitment links data reported from community participants to clinical data in the EHR and allows for eligibility verification and automated follow-up. The workflow has the potential to improve recruitment efficiency and engage traditionally underrepresented individuals in research. Schattauer GmbH Stuttgart.

  9. Imaging mass spectrometry in microbiology

    PubMed Central

    Watrous, Jeramie D.; Dorrestein, Pieter C.

    2013-01-01

    Mass spectrometry tools which allow for the 2-D visualization of the distribution of trace metals, metabolites, surface lipids, peptides and proteins directly from biological samples without the need for chemical tagging or antibodies are becoming increasingly useful for microbiology applications. These tools, comprised of different imaging mass spectrometry techniques, are ushering in an exciting new era of discovery by allowing for the generation of chemical hypotheses based on of the spatial mapping of atoms and molecules that can correlate to or transcend observed phenotypes. In this review, we explore the wide range of imaging mass spectrometry techniques available to microbiologists and describe their unique applications to microbiology with respect to the types of microbiology samples to be investigated. PMID:21822293

  10. Towards quantifying global aerosol radiative effects using lidar

    NASA Astrophysics Data System (ADS)

    Thorsen, T. J.

    2017-12-01

    Spaceborne lidar observations alleviate many of the limitations of passivesensors and have great potential to provide accurate global all-sky estimatesof the aerosol direct radiative effect (DRE). However, analysis of CALIPSOlidar observations show that CALIPSO does not detect allradiatively-significant aerosol, i.e. aerosol that directly modifies theEarth's radiation budget. We estimated that using CALIPSO observationsresults in an underestimate of the magnitude of the global mean aerosol DREby up to 54%. The CATS lidar on-board the ISS is shown to have a poorersensitivity than CALIPSO and the expected sensitivity of the upcoming ATLIDlidar on EarthCARE indicates that calculations of the aerosol DRE willcontinue to be significantly biased. Improvements to our knowledge of aerosol forcing, which contributes thelargest uncertainty to climate sensitivity, could be achieved by a futurespace-based HSRL mission. To this end, high-accuracy ground-based andairborne lidar datasets have been used to compute the detection sensitivityrequired to accurately resolve the aerosol DRE. Multiwavelength HSRLmeasurements also can retrieve vertically-resolved aerosol optical propertiesneeded for radiative transfer calculations which are not provided by currentsatellite observations. Current satellite observations also do not provideall the quantities needed to compute the aerosol direct radiative forcing,i.e. the radiative effect of just anthropogenic aerosols. A multiwavelengthHSRL allows for a more refined aerosol classification to be made enablingboth calculations of anthropogenic aerosol radiative effects and betterconstraints on global models.

  11. The FUSE Survey of Algol-Type Interacting Binary Systems

    NASA Astrophysics Data System (ADS)

    Peters, Geraldine J.; Andersson, B.; Ake, T. B.; Sankrit, R.

    2006-12-01

    A survey of Algol binaries at random phases is currently being carried through with the FUSE spacecraft as part of the FUSE survey and supplemental program. A similar program was undertaken in FUSE Cycle 3. Both programs have produced multiple observations of 12 Algol systems with periods ranging from 1.2 37 d and include direct-impact and disk systems. We report on the status of the program. The absence of O VI absorption in the systems observed to date allows us to place an upper limit on the column density and temperature of the High Temperature Accretion Region, HTAR ( 100,000 K) confirmed in some Algols from earlier IUE data. The HTAR plasma component appears to be distinct from an O VI-emitting polar plasma discovered in FUSE totality observations of RY Per, V356 Sgr, and TT Hya. New observations of the direct-impact system U Cep have provided more information on the geometry and mass flow (including a splash plasma) in the vicinity of a hot spot at phase 0.90 that was discovered earlier. The extent of disk asymmetries in the long period ( 33 d) systems SX Cas and RX Cas is discussed. Models for direct-impact and the disk systems will be presented. The authors appreciate support from NASA grants NAG5-12253, NNG04GL17G, and NAS5-32985.

  12. Rapid Non-Gaussian Uncertainty Quantification of Seismic Velocity Models and Images

    NASA Astrophysics Data System (ADS)

    Ely, G.; Malcolm, A. E.; Poliannikov, O. V.

    2017-12-01

    Conventional seismic imaging typically provides a single estimate of the subsurface without any error bounds. Noise in the observed raw traces as well as the uncertainty of the velocity model directly impact the uncertainty of the final seismic image and its resulting interpretation. We present a Bayesian inference framework to quantify uncertainty in both the velocity model and seismic images, given noise statistics of the observed data.To estimate velocity model uncertainty, we combine the field expansion method, a fast frequency domain wave equation solver, with the adaptive Metropolis-Hastings algorithm. The speed of the field expansion method and its reduced parameterization allows us to perform the tens or hundreds of thousands of forward solves needed for non-parametric posterior estimations. We then migrate the observed data with the distribution of velocity models to generate uncertainty estimates of the resulting subsurface image. This procedure allows us to create both qualitative descriptions of seismic image uncertainty and put error bounds on quantities of interest such as the dip angle of a subduction slab or thickness of a stratigraphic layer.

  13. Electrochemical Transfer of S Between Molten Steel and Molten Slag

    NASA Astrophysics Data System (ADS)

    Kim, Dong-Hyun; Kim, Wook; Kang, Youn-Bae

    2018-06-01

    S transfer between molten steel and molten slag was investigated in view of the electrochemical character of S transfer. C-saturated molten steel containing S was allowed to react with CaO-SiO2-Al2O3-MgO slag at 1673 K (1400 °C) until the two phases arrive at a chemical equilibrium. The application of an electric field of constant current through graphite electrodes lowered the S content in the molten steel below its chemical equilibrium level, and the system arrived at a new equilibrium level (electrochemical equilibrium). However, subsequent shutting off of the electric field did not lead to the system reverting to the original chemical equilibrium: reversion of S was observed but to a limited extent. The application of an electric field of opposite direction or flowing of CO gas allowed significant reversion of S. Side reactions (decomposition of oxide components) were observed, and these were considered to be coupled to the transfer of S. An electrochemical reaction mechanism was proposed based on the experimental observations found in the present study.

  14. New Observations of the Martian Ionosphere and its Variability - An Overview

    NASA Astrophysics Data System (ADS)

    Kopf, Andrew J.

    2017-04-01

    The Martian ionosphere is a highly variable system, owed to the strong influence of the Sun on its properties and behavior, particularly at higher altitudes. Recent measurements from the MAVEN and Mars Express spacecraft have allowed for a more complete understanding of the ionosphere and its variability from two different perspectives. Due to the low-altitude periapsis of its orbit, MAVEN has allowed for the first in-situ ionospheric studies since Viking, yielding detailed direct measurements of the ionosphere's structure, composition, and dynamics, as well as its rate of loss to space. Mars Express has over a decade of continuous ionospheric observation of the red planet, with the unique ability to remotely sound the ionosphere. These features enable Mars Express to make long-period ionospheric measurements on each orbit, at all local times and solar zenith angles. Utilized together, these two spacecraft form a powerful observational suite that has provided new insights into this dynamic environment. This talk will highlight several important recent results in the study of the Martian ionosphere and its variability.

  15. Transition regime from step-flow to step-bunching in the growth of epitaxial SrRuO3 on (001) SrTiO3

    NASA Astrophysics Data System (ADS)

    Gura, Anna; Bertino, Giulia; Bein, Benjamin; Dawber, Matthew

    2018-04-01

    We present a study of the surface morphology of SrRuO3 thin films grown on TiO2 terminated (001) SrTiO3 substrates using an off-axis RF magnetron sputtering deposition technique. We investigated the step bunching formation and the evolution of the films by varying deposition parameters. The thin films were characterized using atomic force microscopy methods, allowing us to study the various growth regimes of SrRuO3 as a function of the growth parameters. We observe a strong influence of both the miscut angle and growth temperature on the evolution of the SrRuO3 surface morphology. In addition, a thickness dependence is present. Remarkably, the formation of a smooth, regular, and uniform "fish-skin" structure at the step-bunch transition is observed. The fish-skin morphology results from the merging of 2D flat islands predicted by previous models. The direct observation of surface evolution allows us to better understand the different growth regimes of SrRuO3 thin films.

  16. Direct Imaging of Warm Extrasolar Planets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Macintosh, B

    2005-04-11

    One of the most exciting scientific discoveries in the last decade of the twentieth century was the first detection of planets orbiting a star other than our own. By now more than 130 extrasolar planets have been discovered indirectly, by observing the gravitational effects of the planet on the radial velocity of its parent star. This technique has fundamental limitations: it is most sensitive to planets close to their star, and it determines only a planet's orbital period and a lower limit on the planet's mass. As a result, all the planetary systems found so far are very different frommore » our own--they have giant Jupiter-sized planets orbiting close to their star, where the terrestrial planets are found in our solar system. Such systems have overturned the conventional paradigm of planet formation, but have no room in them for habitable Earth-like planets. A powerful complement to radial velocity detections of extrasolar planets will be direct imaging--seeing photons from the planet itself. Such a detection would allow photometric measurements to determine the temperature and radius of a planet. Also, direct detection is most sensitive to planets in wide orbits, and hence more capable of seeing solar systems resembling our own, since a giant planet in a wide orbit does not preclude the presence of an Earth-like planet closer to the star. Direct detection, however, is extremely challenging. Jupiter is roughly a billion times fainter than our sun. Two techniques allowed us to overcome this formidable contrast and attempt to see giant planets directly. The first is adaptive optics (AO) which allows giant earth-based telescopes, such as the 10 meter W.M. Keck telescope, to partially overcome the blurring effects of atmospheric turbulence. The second is looking for young planets: by searching in the infrared for companions to young stars, we can see thermal emission from planets that are still warm with the heat of their formation. Together with a UCLA team that leads the field of young-star identification, we carried out a systematic near-infrared search for young planetary companions to {approx}200 young stars. We also carried out targeted high-sensitivity observations of selected stars surrounded by circumstellar dust rings. We developed advanced image processing techniques to allow detection of even fainter sources buried in the noisy halo of scattered starlight. Even with these techniques, around most of our targets our search was only sensitive to planets in orbits significantly wider than our solar system. With some carefully selected targets--very young dusty stars in the solar neighborhood--we reach sensitivities sufficient to see solar systems like our own. Although we discovered no unambiguous planets, we can significantly constrain the frequency of such planets in wide (>50 AU) orbits, which helps determine which models of planet formation remain plausible. Successful modeling of our observations has led us to the design of a next-generation AO system that will truly be capable of exploring solar systems resembling our own.« less

  17. Reafferent copies of imitated actions in the right superior temporal cortex

    PubMed Central

    Iacoboni, Marco; Koski, Lisa M.; Brass, Marcel; Bekkering, Harold; Woods, Roger P.; Dubeau, Marie-Charlotte; Mazziotta, John C.; Rizzolatti, Giacomo

    2001-01-01

    Imitation is a complex phenomenon, the neural mechanisms of which are still largely unknown. When individuals imitate an action that already is present in their motor repertoire, a mechanism matching the observed action onto an internal motor representation of that action should suffice for the purpose. When one has to copy a new action, however, or to adjust an action present in one's motor repertoire to a different observed action, an additional mechanism is needed that allows the observer to compare the action made by another individual with the sensory consequences of the same action made by himself. Previous experiments have shown that a mechanism that directly matches observed actions on their motor counterparts exists in the premotor cortex of monkeys and humans. Here we report the results of functional magnetic resonance experiments, suggesting that in the superior temporal sulcus, a higher order visual region, there is a sector that becomes active both during hand action observation and during imitation even in the absence of direct vision of the imitator's hand. The motor-related activity is greater during imitation than during control motor tasks. This newly identified region has all the requisites for being the region at which the observed actions, and the reafferent motor-related copies of actions made by the imitator, interact. PMID:11717457

  18. On the Relationship Between Scintillation Anisotropy and Crystal Structure in Pure Crystalline Organic Scintillator Materials

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schuster, Patricia; Feng, Patrick; Brubaker, Erik

    We report the scintillation anisotropy effect for proton recoil events has been investigated in five pure organic crystalline materials: anthracene, trans-stilbene, p-terphenyl, bibenzyl, and diphenylacetylene. These measurements include characterization of the scintillation response for one hemisphere of proton recoil directions in each crystal. In addition to standard measurements of the total light output and pulse shape at each angle, the prompt and delayed light anisotropies are analyzed, allowing for investigation of the singlet and triplet molecular excitation behaviors independently. This work provides new quantitative and qualitative observations that make progress toward understanding the physical mechanisms behind the scintillation anisotropy. Thesemore » measurements show that the relationship between the prompt and delayed light anisotropies is correlated with crystal structure, as it changes between the pi-stacked crystal structure materials (anthracene and p-terphenyl) and the herringbone crystal structure materials (stilbene, bibenzyl, and diphenylacetylene). The observations are consistent with a model in which there are preferred directions of kinetic processes for the molecular excitations. Finally, these processes and the impact of their directional dependencies on the scintillation anisotropy are discussed.« less

  19. In-situ temperature field measurements and direct observation of crystal/melt at vertical Bridgman growth of lead chloride under stationary and dynamic arrangement

    NASA Astrophysics Data System (ADS)

    Král, Robert; Nitsch, Karel

    2015-10-01

    Influence of growth conditions, i.e. temperature gradient in the furnace and the pulling rate, on the position and the shape of the crystal/melt interface during vertical Bridgman growth was studied. The position and the shape of the crystal/melt interface are a key factor for describing the final quality of growing crystal. Following two methods for characterization of its position and shape were used: (i) direct observation and (ii) direct temperature field measurement during simulated vertical Bridgman growth. As a model compound a lead chloride is used. Three different ampoule positions in two different temperature gradients in the furnace and two experimental arrangements - stationary (0 mm/h pulling rate) and dynamic (3 mm/h pulling rate) were analyzed. Obtained temperature data were projected as 2D planar cut under radial symmetry and denoted as isolevels. Their further conversion by linear approximation into isotherms allowed detail analysis of heat conditions in the system during simulated growth by comparison of isotherms 500 °C (m.p. of lead chloride) at different growth conditions.

  20. On the Relationship Between Scintillation Anisotropy and Crystal Structure in Pure Crystalline Organic Scintillator Materials

    DOE PAGES

    Schuster, Patricia; Feng, Patrick; Brubaker, Erik

    2018-05-03

    We report the scintillation anisotropy effect for proton recoil events has been investigated in five pure organic crystalline materials: anthracene, trans-stilbene, p-terphenyl, bibenzyl, and diphenylacetylene. These measurements include characterization of the scintillation response for one hemisphere of proton recoil directions in each crystal. In addition to standard measurements of the total light output and pulse shape at each angle, the prompt and delayed light anisotropies are analyzed, allowing for investigation of the singlet and triplet molecular excitation behaviors independently. This work provides new quantitative and qualitative observations that make progress toward understanding the physical mechanisms behind the scintillation anisotropy. Thesemore » measurements show that the relationship between the prompt and delayed light anisotropies is correlated with crystal structure, as it changes between the pi-stacked crystal structure materials (anthracene and p-terphenyl) and the herringbone crystal structure materials (stilbene, bibenzyl, and diphenylacetylene). The observations are consistent with a model in which there are preferred directions of kinetic processes for the molecular excitations. Finally, these processes and the impact of their directional dependencies on the scintillation anisotropy are discussed.« less

  1. Asymmetry in the Outburst of SN 1987A Detected Using Light Echo Spectroscopy

    NASA Astrophysics Data System (ADS)

    Sinnott, B.; Welch, D. L.; Rest, A.; Sutherland, P. G.; Bergmann, M.

    2013-04-01

    We report direct evidence for asymmetry in the early phases of SN 1987A via optical spectroscopy of five fields of its light echo system. The light echoes allow the first few hundred days of the explosion to be reobserved, with different position angles providing different viewing angles to the supernova. Light echo spectroscopy therefore allows a direct spectroscopic comparison of light originating from different regions of the photosphere during the early phases of SN 1987A. Gemini multi-object spectroscopy of the light echo fields shows fine structure in the Hα line as a smooth function of position angle on the near-circular light echo rings. Hα profiles originating from the northern hemisphere of SN 1987A show an excess in redshifted emission and a blue knee, while southern hemisphere profiles show an excess of blueshifted Hα emission and a red knee. This fine structure is reminiscent of the "Bochum event" originally observed for SN 1987A, but in an exaggerated form. Maximum deviation from symmetry in the Hα line is observed at position angles 16° and 186°, consistent with the major axis of the expanding elongated ejecta. The asymmetry signature observed in the Hα line smoothly diminishes as a function of viewing angle away from the poles of the elongated ejecta. We propose an asymmetric two-sided distribution of 56Ni most dominant in the southern far quadrant of SN 1987A as the most probable explanation of the observed light echo spectra. This is evidence that the asymmetry of high-velocity 56Ni in the first few hundred days after explosion is correlated to the geometry of the ejecta some 25 years later.

  2. Type II Radio Bursts Observed by STEREO/Waves and Wind/Waves instruments

    NASA Astrophysics Data System (ADS)

    Krupar, V.; Magdalenic, J.; Zhukov, A.; Rodriguez, L.; Mierla, M.; Maksimovic, M.; Cecconi, B.; Santolik, O.

    2013-12-01

    Type II radio bursts are slow-drift emissions triggered by suprathermal electrons accelerated on shock fronts of propagating CMEs. We present several events at kilometric wavelengths observed by radio instruments onboard the STEREO and Wind spacecraft. The STEREO/Waves and Wind/Waves have goniopolarimetric (GP, also referred to as direction finding) capabilities that allow us to triangulate radio sources when an emission is observed by two or more spacecraft. As the GP inversion has high requirements on the signal-to-noise ratio we only have a few type II radio bursts with sufficient intensity for this analysis. We have compared obtained radio sources with white-light observations of STEREO/COR and STEREO/HI instruments. Our preliminary results indicate that radio sources are located at flanks of propagating CMEs.

  3. The First Simultaneous Microlensing Observations by Two Space Telescopes: Spitzer and Swift Reveal a Brown Dwarf in Event OGLE-2015-BLG-1319

    NASA Technical Reports Server (NTRS)

    Shvartzvald, Y.; Li, Z.; Udalski, A.; Gould, A.; Sumi, T.; Street, R. A.; Calchi Novati, S.; Hundertmark, M.; Bozza, V.; Beichman, C.; hide

    2016-01-01

    Simultaneous observations of microlensing events from multiple locations allow for the breaking of degeneracies between the physical properties of the lensing system, specifically by exploring different regions of the lens plane and by directly measuring the "microlens parallax". We report the discovery of a 30-65M J brown dwarf orbiting a K dwarf in the microlensing event OGLE-2015-BLG-1319. The system is located at a distance of approximately 5 kpc toward the Galactic Bulge. The event was observed by several ground-based groups as well as by Spitzer and Swift, allowing a measurement of the physical properties. However, the event is still subject to an eight-fold degeneracy, in particular the well-known close-wide degeneracy, and thus the projected separation between the two lens components is either approximately 0.25 au or approximately 45 au. This is the first microlensing event observed by Swift, with the UVOT camera. We study the region of microlensing parameter space to which Swift is sensitive, finding that though Swift could not measure the microlens parallax with respect to ground-based observations for this event, it can be important for other events. Specifically, it is important for detecting nearby brown dwarfs and free-floating planets in high magnification events.

  4. 49 CFR 40.63 - What steps does the collector take in the collection process before the employee provides a urine...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Either you or the employee, with both of you present, must unwrap or break the seal of the collection container. You must not unwrap or break the seal on any specimen bottle at this time. You must not allow the... direct observation and the reason for doing so. [65 FR 79526, Dec. 19, 2000, as amended at 75 FR 59107...

  5. The Dynamics of the Photofragmentation of Ketene 3-Cyclopentenone, 3,5-Cycloheptadienone, and Tropone.

    DTIC Science & Technology

    1985-01-01

    suggested that the concerted reaction should be allowed photochemically and the conrotatory mode should be favored. The data were in accord with this...crossing), or (4) reaction to form products, e.g., isomers or fragments, directly from the excited state. Further radiative, non-radiative, and photochemical ...processes can occur from intermediate excited states. Typical photochemical reactions observed in simple ketones in the gas phase are: (1) Norrish

  6. Gravitational wave, collider and dark matter signals from a scalar singlet electroweak baryogenesis

    DOE PAGES

    Beniwal, Ankit; Lewicki, Marek; Wells, James D.; ...

    2017-08-23

    We analyse a simple extension of the SM with just an additional scalar singlet coupled to the Higgs boson. Here, we discuss the possible probes for electroweak baryogenesis in this model including collider searches, gravitational wave and direct dark matter detection signals. We show that a large portion of the model parameter space exists where the observation of gravitational waves would allow detection while the indirect collider searches would not.

  7. Prospects for observation at CERN in NA62

    NASA Astrophysics Data System (ADS)

    Hahn, F.; NA62 Collaboration; Aglieri Rinella, G.; Aliberti, R.; Ambrosino, F.; Angelucci, B.; Antonelli, A.; Anzivino, G.; Arcidiacono, R.; Azhinenko, I.; Balev, S.; Bendotti, J.; Biagioni, A.; Biino, C.; Bizzeti, A.; Blazek, T.; Blik, A.; Bloch-Devaux, B.; Bolotov, V.; Bonaiuto, V.; Bragadireanu, M.; Britton, D.; Britvich, G.; Brook, N.; Bucci, F.; Butin, F.; Capitolo, E.; Capoccia, C.; Capussela, T.; Carassiti, V.; Cartiglia, N.; Cassese, A.; Catinaccio, A.; Cecchetti, A.; Ceccucci, A.; Cenci, P.; Cerny, V.; Cerri, C.; Chikilev, O.; Ciaranfi, R.; Collazuol, G.; Cooke, P.; Cooper, P.; Corradi, G.; Cortina Gil, E.; Costantini, F.; Cotta Ramusino, A.; Coward, D.; D'Agostini, G.; Dainton, J.; Dalpiaz, P.; Danielsson, H.; Degrange, J.; De Simone, N.; Di Filippo, D.; Di Lella, L.; Dixon, N.; Doble, N.; Duk, V.; Elsha, V.; Engelfried, J.; Enik, T.; Falaleev, V.; Fantechi, R.; Federici, L.; Fiorini, M.; Fry, J.; Fucci, A.; Fulton, L.; Gallorini, S.; Gatignon, L.; Gianoli, A.; Giudici, S.; Glonti, L.; Goncalves Martins, A.; Gonnella, F.; Goudzovski, E.; Guida, R.; Gushchin, E.; Hahn, F.; Hallgren, B.; Heath, H.; Herman, F.; Hutchcroft, D.; Iacopini, E.; Jamet, O.; Jarron, P.; Kampf, K.; Kaplon, J.; Karjavin, V.; Kekelidze, V.; Kholodenko, S.; Khoriauli, G.; Khudyakov, A.; Kiryushin, Yu; Kleinknecht, K.; Kluge, A.; Koval, M.; Kozhuharov, V.; Krivda, M.; Kudenko, Y.; Kunze, J.; Lamanna, G.; Lazzeroni, C.; Leitner, R.; Lenci, R.; Lenti, M.; Leonardi, E.; Lichard, P.; Lietava, R.; Litov, L.; Lomidze, D.; Lonardo, A.; Lurkin, N.; Madigozhin, D.; Maire, G.; Makarov, A.; Mannelli, I.; Mannocchi, G.; Mapelli, A.; Marchetto, F.; Massarotti, P.; Massri, K.; Matak, P.; Mazza, G.; Menichetti, E.; Mirra, M.; Misheva, M.; Molokanova, N.; Morant, J.; Morel, M.; Moulson, M.; Movchan, S.; Munday, D.; Napolitano, M.; Newson, F.; Norton, A.; Noy, M.; Nuessle, G.; Obraztsov, V.; Padolski, S.; Page, R.; Palladino, V.; Pardons, A.; Pedreschi, E.; Pepe, M.; Perez Gomez, F.; Perrin-Terrin, M.; Petrov, P.; Petrucci, F.; Piandani, R.; Piccini, M.; Pietreanu, D.; Pinzino, J.; Pivanti, M.; Polenkevich, I.; Popov, I.; Potrebenikov, Yu; Protopopescu, D.; Raffaelli, F.; Raggi, M.; Riedler, P.; Romano, A.; Rubin, P.; Ruggiero, G.; Russo, V.; Ryjov, V.; Salamon, A.; Salina, G.; Samsonov, V.; Santovetti, E.; Saracino, G.; Sargeni, F.; Schifano, S.; Semenov, V.; Sergi, A.; Serra, M.; Shkarovskiy, S.; Sotnikov, A.; Sougonyaev, V.; Sozzi, M.; Spadaro, T.; Spinella, F.; Staley, R.; Statera, M.; Sutcliffe, P.; Szilasi, N.; Tagnani, D.; Valdata-Nappi, M.; Valente, P.; Vasile, M.; Vassilieva, V.; Velghe, B.; Veltri, M.; Venditti, S.; Vormstein, M.; Wahl, H.; Wanke, R.; Wertelaers, P.; Winhart, A.; Winston, R.; Wrona, B.; Yushchenko, O.; Zamkovsky, M.; Zinchenko, A.

    2015-07-01

    The rare decays are excellent processes to probe the Standard Model and indirectly search for new physics complementary to the direct LHC searches. The NA62 experiment at CERN SPS aims to collect and analyse O(1013) kaon decays before the CERN long-shutdown 2 (in 2018). This will allow to measure the branching ratio to a level of 10% accuracy. The experimental apparatus has been commissioned during a first run in autumn 2014.

  8. Gravitational wave, collider and dark matter signals from a scalar singlet electroweak baryogenesis

    NASA Astrophysics Data System (ADS)

    Beniwal, Ankit; Lewicki, Marek; Wells, James D.; White, Martin; Williams, Anthony G.

    2017-08-01

    We analyse a simple extension of the SM with just an additional scalar singlet coupled to the Higgs boson. We discuss the possible probes for electroweak baryogenesis in this model including collider searches, gravitational wave and direct dark matter detection signals. We show that a large portion of the model parameter space exists where the observation of gravitational waves would allow detection while the indirect collider searches would not.

  9. Gravitational wave, collider and dark matter signals from a scalar singlet electroweak baryogenesis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Beniwal, Ankit; Lewicki, Marek; Wells, James D.

    We analyse a simple extension of the SM with just an additional scalar singlet coupled to the Higgs boson. Here, we discuss the possible probes for electroweak baryogenesis in this model including collider searches, gravitational wave and direct dark matter detection signals. We show that a large portion of the model parameter space exists where the observation of gravitational waves would allow detection while the indirect collider searches would not.

  10. Impacts of space weather events on the structure of the upper atmosphere

    NASA Astrophysics Data System (ADS)

    Lee, Y.; Mahaffy, P. R.; Benna, M.; Elrod, M. K.

    2017-12-01

    Due to the absence of the intrinsic magnetic field, Mars' upper atmosphere is vulnerable to the solar wind, which directly strips away the Martian upper atmosphere via various mechanisms, resulting in interesting global phenomena that are observable. The Mars Atmosphere and Volatile EvolutioN (MAVEN) has observed the responses of the upper atmosphere such as Interplanetary Coronal Mass Ejections (ICMEs) and Solar flare events spanning from November 2014 to the present. A comprehensive set of observations taken by the MAVEN instrument package enables the better characterization of the thermospheric and ionospheric behavior affected by various space weather events. The observed impacts include changes in the upper atmospheric and ionospheric density and temperature, enhancements of atmospheric loss rate of ions and neutrals, and changes in important boundary layers. The measurements by plasma and field instruments allows the upstream monitoring of the solar EUV, solar energetic particles, and Interplanetary Magnetic Field (IMF) simultaneously and provide additional information of the near-Mars space weather disturbances. In addition, at low altitudes near the periapsis of the spacecraft, the simultaneous measurements of the magnetic field and properties of the thermosphere and ionosphere allow the analysis of the effects of the local crustal magnetic fields. Here, adding to the reported MAVEN observations of the space weather impacts at Mars, we analyze the responses of the upper atmosphere to the mars-impacting space weather events observed by MAVEN. We focus mainly on the responses of the density and temperature structures, which in turn allow us to examine the effects on the important atmospheric layers such as the M2 layer and transition region from the thermosphere to exosphere.

  11. Synergistic effect of high and low molecular weight molecules in the foamability and foam stability of sparkling wines.

    PubMed

    Coelho, Elisabete; Reis, Ana; Domingues, M Rosário M; Rocha, Sílvia M; Coimbra, Manuel A

    2011-04-13

    The foam of sparkling wines is a key parameter of their quality. However, the compounds that are directly involved in foam formation and stabilization are not yet completely established. In this work, seven sparkling wines were produced in Bairrada appellation (Portugal) under different conditions and their foaming properties evaluated using a Mosalux-based device. Fractionation of the sparkling wines into four independent fractions, (1) high molecular weight material, with molecular weight higher than 12 kDa (HMW), (2) hydrophilic material with molecular weigh between 1 and 12 kDa (AqIMW), (3) hydrophobic material with molecular weigh between 1 and 12 kDa (MeIMW), and (4) hydrophobic material with a molecular weight lower than 1 kDa (MeLMW), allowed the observation that the wines presenting the lower foam stability were those that presented lower amounts of the MeLMW fraction. The fraction that presented the best foam stability was HMW. When HMW is combined with MeLMW fraction, the foam stability largely increased. This increase was even larger, approaching the foam stability of the sparkling wine, when HMW was combined with the less hydrophobic subfraction of MeLMW (fraction 3). Electrospray tandem mass spectrometry (ESI-MS/MS) of fraction 3 allowed the assignment of polyethylene glycol oligomers (n = 5-11) and diethylene glycol 8-hydroxytridecanoate glyceryl acetate. To observe if these molecules occur in sparkling wine foam, the MeLMW was recovered directly from the sparkling wine foam and was also analyzed by ESI-MS/MS. The presence of monoacylglycerols of palmitic and stearic acids, as well as four glycerylethylene glycol fatty acid derivatives, was observed. These surface active compounds are preferentially partitioned by the sparkling wine foam rather than the liquid phase, allowing the inference of their role as key components in the promotion and stabilization of sparkling wine foam.

  12. Global Night-Time Lights for Observing Human Activity

    NASA Technical Reports Server (NTRS)

    Hipskind, Stephen R.; Elvidge, Chris; Gurney, K.; Imhoff, Mark; Bounoua, Lahouari; Sheffner, Edwin; Nemani, Ramakrishna R.; Pettit, Donald R.; Fischer, Marc

    2011-01-01

    We present a concept for a small satellite mission to make systematic, global observations of night-time lights with spatial resolution suitable for discerning the extent, type and density of human settlements. The observations will also allow better understanding of fine scale fossil fuel CO2 emission distribution. The NASA Earth Science Decadal Survey recommends more focus on direct observations of human influence on the Earth system. The most dramatic and compelling observations of human presence on the Earth are the night light observations taken by the Defence Meteorological System Program (DMSP) Operational Linescan System (OLS). Beyond delineating the footprint of human presence, night light data, when assembled and evaluated with complementary data sets, can determine the fine scale spatial distribution of global fossil fuel CO2 emissions. Understanding fossil fuel carbon emissions is critical to understanding the entire carbon cycle, and especially the carbon exchange between terrestrial and oceanic systems.

  13. Exploring synchronisation in nonlinear data assimilation

    NASA Astrophysics Data System (ADS)

    Rodrigues-Pinheiro, Flavia; van Leeuwen, Peter Jan

    2016-04-01

    Present-day data assimilation methods are based on linearizations and face serious problems in strongly nonlinear cases such as convection. A promising solution to this problem is a particle filter, which provides a representation of the model probability density function (pdf) by a discrete set of model states, or particles. The basic particle filter uses Bayes's theorem directly, but does not work in high-dimensional cases. The performance can be improved by considering the proposal density freedom. This allows one to change the model equations to bring the particles closer to the observations, resulting in very efficient update schemes at observation times, but extending these schemes between observation times is computationally expensive. Simple solutions like nudging have been shown to be not powerful enough. A potential solution might be synchronization, in which one tries to synchronise the model of a system with the true evolution of the system via the observations. In practice this means that an extra term is added to the model equations that hampers growth of instabilities on the synchronization manifold. Especially the delayed versions, where observations are allowed to influence the state in the past have shown some remarkable successes. Unfortunately, all efforts ignore errors in the observations, and as soon as these are introduced the performance degrades considerably. There is a close connection between time-delayed synchronization and a Kalman Smoother, which does allow for observational (and other) errors. In this presentation we will explore this connection to the full, with a view to extend synchronization to more realistic settings. Specifically performance of the spread of information from observed to unobserved variables is studied in detail. The results indicate that this extended synchronisation is a promising tool to steer the model states towards the observations efficiently. If time permits, we will show initial results of embedding the new synchronization method into a particle filter.

  14. Digital holographic interferometry applied to the investigation of ignition process.

    PubMed

    Pérez-Huerta, J S; Saucedo-Anaya, Tonatiuh; Moreno, I; Ariza-Flores, D; Saucedo-Orozco, B

    2017-06-12

    We use the digital holographic interferometry (DHI) technique to display the early ignition process for a butane-air mixture flame. Because such an event occurs in a short time (few milliseconds), a fast CCD camera is used to study the event. As more detail is required for monitoring the temporal evolution of the process, less light coming from the combustion is captured by the CCD camera, resulting in a deficient and underexposed image. Therefore, the CCD's direct observation of the combustion process is limited (down to 1000 frames per second). To overcome this drawback, we propose the use of DHI along with a high power laser in order to supply enough light to increase the speed capture, thus improving the visualization of the phenomenon in the initial moments. An experimental optical setup based on DHI is used to obtain a large sequence of phase maps that allows us to observe two transitory stages in the ignition process: a first explosion which slightly emits visible light, and a second stage induced by variations in temperature when the flame is emerging. While the last stage can be directly monitored by the CCD camera, the first stage is hardly detected by direct observation, and DHI clearly evidences this process. Furthermore, our method can be easily adapted for visualizing other types of fast processes.

  15. Ultrafast carrier thermalization and trapping in silicon-germanium alloy probed by extreme ultraviolet transient absorption spectroscopy

    PubMed Central

    Zürch, Michael; Chang, Hung-Tzu; Kraus, Peter M.; Cushing, Scott K.; Borja, Lauren J.; Gandman, Andrey; Kaplan, Christopher J.; Oh, Myoung Hwan; Prell, James S.; Prendergast, David; Pemmaraju, Chaitanya D.; Neumark, Daniel M.; Leone, Stephen R.

    2017-01-01

    Semiconductor alloys containing silicon and germanium are of growing importance for compact and highly efficient photonic devices due to their favorable properties for direct integration into silicon platforms and wide tunability of optical parameters. Here, we report the simultaneous direct and energy-resolved probing of ultrafast electron and hole dynamics in a silicon-germanium alloy with the stoichiometry Si0.25Ge0.75 by extreme ultraviolet transient absorption spectroscopy. Probing the photoinduced dynamics of charge carriers at the germanium M4,5-edge (∼30 eV) allows the germanium atoms to be used as reporter atoms for carrier dynamics in the alloy. The photoexcitation of electrons across the direct and indirect band gap into conduction band (CB) valleys and their subsequent hot carrier relaxation are observed and compared to pure germanium, where the Ge direct (ΔEgap,Ge,direct=0.8 eV) and Si0.25Ge0.75 indirect gaps (ΔEgap,Si0.25Ge0.75,indirect=0.95 eV) are comparable in energy. In the alloy, comparable carrier lifetimes are observed for the X, L, and Γ valleys in the conduction band. A midgap feature associated with electrons accumulating in trap states near the CB edge following intraband thermalization is observed in the Si0.25Ge0.75 alloy. The successful implementation of the reporter atom concept for capturing the dynamics of the electronic bands by site-specific probing in solids opens a route to study carrier dynamics in more complex materials with femtosecond and sub-femtosecond temporal resolution. PMID:28653020

  16. 42 CFR 405.2468 - Allowable costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... to the limit on the all-inclusive rate for allowable costs. (3) Allowable graduate medical education.... (f) Graduate medical education. (1) Effective for that portion of cost reporting periods occurring on... receive direct graduate medical education payment for those residents. (2) Direct graduate medical...

  17. The persistent cosmic web and its filamentary structure - I. Theory and implementation

    NASA Astrophysics Data System (ADS)

    Sousbie, T.

    2011-06-01

    We present DisPerSE, a novel approach to the coherent multiscale identification of all types of astrophysical structures, in particular the filaments, in the large-scale distribution of the matter in the Universe. This method and the corresponding piece of software allows for a genuinely scale-free and parameter-free identification of the voids, walls, filaments, clusters and their configuration within the cosmic web, directly from the discrete distribution of particles in N-body simulations or galaxies in sparse observational catalogues. To achieve that goal, the method works directly over the Delaunay tessellation of the discrete sample and uses the Delaunay tessellation field estimator density computed at each tracer particle; no further sampling, smoothing or processing of the density field is required. The idea is based on recent advances in distinct subdomains of the computational topology, namely the discrete Morse theory which allows for a rigorous application of topological principles to astrophysical data sets, and the theory of persistence, which allows us to consistently account for the intrinsic uncertainty and Poisson noise within data sets. Practically, the user can define a given persistence level in terms of robustness with respect to noise (defined as a 'number of σ') and the algorithm returns the structures with the corresponding significance as sets of critical points, lines, surfaces and volumes corresponding to the clusters, filaments, walls and voids - filaments, connected at cluster nodes, crawling along the edges of walls bounding the voids. From a geometrical point of view, the method is also interesting as it allows for a robust quantification of the topological properties of a discrete distribution in terms of Betti numbers or Euler characteristics, without having to resort to smoothing or having to define a particular scale. In this paper, we introduce the necessary mathematical background and describe the method and implementation, while we address the application to 3D simulated and observed data sets in the companion paper (Sousbie, Pichon & Kawahara, Paper II).

  18. The total carbon column observing network.

    PubMed

    Wunch, Debra; Toon, Geoffrey C; Blavier, Jean-François L; Washenfelder, Rebecca A; Notholt, Justus; Connor, Brian J; Griffith, David W T; Sherlock, Vanessa; Wennberg, Paul O

    2011-05-28

    A global network of ground-based Fourier transform spectrometers has been founded to remotely measure column abundances of CO(2), CO, CH(4), N(2)O and other molecules that absorb in the near-infrared. These measurements are directly comparable with the near-infrared total column measurements from space-based instruments. With stringent requirements on the instrumentation, acquisition procedures, data processing and calibration, the Total Carbon Column Observing Network (TCCON) achieves an accuracy and precision in total column measurements that is unprecedented for remote-sensing observations (better than 0.25% for CO(2)). This has enabled carbon-cycle science investigations using the TCCON dataset, and allows the TCCON to provide a link between satellite measurements and the extensive ground-based in situ network. © 2011 The Royal Society

  19. Simultaneous observation of chemomechanical coupling of a molecular motor.

    PubMed

    Nishizaka, Takayuki; Hasimoto, Yuh; Masaike, Tomoko

    2011-01-01

    F(1)-ATPase is the smallest rotary molecular motor ever found. Unidirectional rotation of the γ-shaft is driven by precisely coordinated sequential ATP hydrolysis reactions in three catalytic sites arranged 120° apart in the cylinder. Single-molecule observation allows us to directly watch the rotation of the shaft using micron-sized plastic beads. Additionally, an advanced version of "total internal reflection fluorescence microscope (TIRFM)" enables us to detect binding and release of energy currency through fluorescently labeled ATP. In this chapter, we describe how to set up the system for simultaneous observation of these two critical events. This specialized optical setup is applicable to a variety of research, not only molecular motors but also other single-molecule topics.

  20. The Strabo digital data system for Structural Geology and Tectonics

    NASA Astrophysics Data System (ADS)

    Tikoff, Basil; Newman, Julie; Walker, J. Doug; Williams, Randy; Michels, Zach; Andrews, Joseph; Bunse, Emily; Ash, Jason; Good, Jessica

    2017-04-01

    We are developing the Strabo data system for the structural geology and tectonics community. The data system will allow researchers to share primary data, apply new types of analytical procedures (e.g., statistical analysis), facilitate interaction with other geology communities, and allow new types of science to be done. The data system is based on a graph database, rather than relational database approach, to increase flexibility and allow geologically realistic relationships between observations and measurements. Development is occurring on: 1) A field-based application that runs on iOS and Android mobile devices and can function in either internet connected or disconnected environments; and 2) A desktop system that runs only in connected settings and directly addresses the back-end database. The field application also makes extensive use of images, such as photos or sketches, which can be hierarchically arranged with encapsulated field measurements/observations across all scales. The system also accepts Shapefile, GEOJSON, KML formats made in ArcGIS and QGIS, and will allow export to these formats as well. Strabo uses two main concepts to organize the data: Spots and Tags. A Spot is any observation that characterizes a specific area. Below GPS resolution, a Spot can be tied to an image (outcrop photo, thin section, etc.). Spots are related in a purely spatial manner (one spot encloses anther spot, which encloses another, etc.). Tags provide a linkage between conceptually related spots. Together, this organization works seamlessly with the workflow of most geologists. We are expanding this effort to include microstructural data, as well as to the disciplines of sedimentology and petrology.

  1. A reduced adaptive observer for multivariable systems. [using reduced dynamic ordering

    NASA Technical Reports Server (NTRS)

    Carroll, R. L.; Lindorff, D. P.

    1973-01-01

    An adaptive observer for multivariable systems is presented for which the dynamic order of the observer is reduced, subject to mild restrictions. The observer structure depends directly upon the multivariable structure of the system rather than a transformation to a single-output system. The number of adaptive gains is at most the sum of the order of the system and the number of input parameters being adapted. Moreover, for the relatively frequent specific cases for which the number of required adaptive gains is less than the sum of system order and input parameters, the number of these gains is easily determined by inspection of the system structure. This adaptive observer possesses all the properties ascribed to the single-input single-output adpative observer. Like the other adaptive observers some restriction is required of the allowable system command input to guarantee convergence of the adaptive algorithm, but the restriction is more lenient than that required by the full-order multivariable observer. This reduced observer is not restricted to cycle systems.

  2. Detecting surface runoff location in a small catchment using distributed and simple observation method

    NASA Astrophysics Data System (ADS)

    Dehotin, Judicaël; Breil, Pascal; Braud, Isabelle; de Lavenne, Alban; Lagouy, Mickaël; Sarrazin, Benoît

    2015-06-01

    Surface runoff is one of the hydrological processes involved in floods, pollution transfer, soil erosion and mudslide. Many models allow the simulation and the mapping of surface runoff and erosion hazards. Field observations of this hydrological process are not common although they are crucial to evaluate surface runoff models and to investigate or assess different kinds of hazards linked to this process. In this study, a simple field monitoring network is implemented to assess the relevance of a surface runoff susceptibility mapping method. The network is based on spatially distributed observations (nine different locations in the catchment) of soil water content and rainfall events. These data are analyzed to determine if surface runoff occurs. Two surface runoff mechanisms are considered: surface runoff by saturation of the soil surface horizon and surface runoff by infiltration excess (also called hortonian runoff). The monitoring strategy includes continuous records of soil surface water content and rainfall with a 5 min time step. Soil infiltration capacity time series are calculated using field soil water content and in situ measurements of soil hydraulic conductivity. Comparison of soil infiltration capacity and rainfall intensity time series allows detecting the occurrence of surface runoff by infiltration-excess. Comparison of surface soil water content with saturated water content values allows detecting the occurrence of surface runoff by saturation of the soil surface horizon. Automatic records were complemented with direct field observations of surface runoff in the experimental catchment after each significant rainfall event. The presented observation method allows the identification of fast and short-lived surface runoff processes at a small spatial and temporal resolution in natural conditions. The results also highlight the relationship between surface runoff and factors usually integrated in surface runoff mapping such as topography, rainfall parameters, soil or land cover. This study opens interesting prospects for the use of spatially distributed measurement for surface runoff detection, spatially distributed hydrological models implementation and validation at a reasonable cost.

  3. Dissecting the mechanism of martensitic transformation via atomic-scale observations.

    PubMed

    Yang, Xu-Sheng; Sun, Sheng; Wu, Xiao-Lei; Ma, Evan; Zhang, Tong-Yi

    2014-08-21

    Martensitic transformation plays a pivotal role in the microstructural evolution and plasticity of many engineering materials. However, so far the underlying atomic processes that accomplish the displacive transformation have been obscured by the difficulty in directly observing key microstructural signatures on atomic scale. To resolve this long-standing problem, here we examine an AISI 304 austenitic stainless steel that has a strain/microstructure-gradient induced by surface mechanical attrition, which allowed us to capture in one sample all the key interphase regions generated during the γ(fcc) → ε(hcp) → α'(bcc) transition, a prototypical case of deformation induced martensitic transformation (DIMT). High-resolution transmission electron microscopy (HRTEM) observations confirm the crucial role of partial dislocations, and reveal tell-tale features including the lattice rotation of the α' martensite inclusion, the transition lattices at the ε/α' interfaces that cater the shears, and the excess reverse shear-shuffling induced γ necks in the ε martensite plates. These direct observations verify for the first time the 50-year-old Bogers-Burgers-Olson-Cohen (BBOC) model, and enrich our understanding of DIMT mechanisms. Our findings have implications for improved microstructural control in metals and alloys.

  4. Dissecting the Mechanism of Martensitic Transformation via Atomic-Scale Observations

    PubMed Central

    Yang, Xu-Sheng; Sun, Sheng; Wu, Xiao-Lei; Ma, Evan; Zhang, Tong-Yi

    2014-01-01

    Martensitic transformation plays a pivotal role in the microstructural evolution and plasticity of many engineering materials. However, so far the underlying atomic processes that accomplish the displacive transformation have been obscured by the difficulty in directly observing key microstructural signatures on atomic scale. To resolve this long-standing problem, here we examine an AISI 304 austenitic stainless steel that has a strain/microstructure-gradient induced by surface mechanical attrition, which allowed us to capture in one sample all the key interphase regions generated during the γ(fcc) → ε(hcp) → α′(bcc) transition, a prototypical case of deformation induced martensitic transformation (DIMT). High-resolution transmission electron microscopy (HRTEM) observations confirm the crucial role of partial dislocations, and reveal tell-tale features including the lattice rotation of the α′ martensite inclusion, the transition lattices at the ε/α′ interfaces that cater the shears, and the excess reverse shear-shuffling induced γ necks in the ε martensite plates. These direct observations verify for the first time the 50-year-old Bogers-Burgers-Olson-Cohen (BBOC) model, and enrich our understanding of DIMT mechanisms. Our findings have implications for improved microstructural control in metals and alloys. PMID:25142283

  5. Disappearance of "phantom limb" and amputated arm usage during dreaming in REM sleep behaviour disorder.

    PubMed

    Vetrugno, Roberto; Arnulf, Isabelle; Montagna, Pasquale

    2009-01-01

    Limb amputation is followed, in approximately 90% of patients, by "phantom limb" sensations during wakefulness. When amputated patients dream, however, the phantom limb may be present all the time, part of the time, intermittently or not at all. Such dreaming experiences in amputees have usually been obtained only retrospectively in the morning and, moreover, dreaming is normally associated with muscular atonia so the motor counterpart of the phantom limb experience cannot be observed directly. REM sleep behaviour disorder (RBD), in which muscle atonia is absent during REM sleep and patients act out their dreams, allows a more direct analysis of the "phantom limb" phenomena and their modifications during sleep.

  6. Near-infrared emitting In-rich InGaN layers grown directly on Si: Towards the whole composition range

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aseev, Pavel, E-mail: pavel.aseev@upm.es; Rodriguez, Paul E. D. Soto; Gómez, Víctor J.

    The authors report compact and chemically homogeneous In-rich InGaN layers directly grown on Si (111) by plasma-assisted molecular beam epitaxy. High structural and optical quality is evidenced by transmission electron microscopy, near-field scanning optical microscopy, and X-ray diffraction. Photoluminescence emission in the near-infrared is observed up to room temperature covering the important 1.3 and 1.55 μm telecom wavelength bands. The n-InGaN/p-Si interface is ohmic due to the absence of any insulating buffer layers. This qualitatively extends the application fields of III-nitrides and allows their integration with established Si technology.

  7. Shape: A 3D Modeling Tool for Astrophysics.

    PubMed

    Steffen, Wolfgang; Koning, Nicholas; Wenger, Stephan; Morisset, Christophe; Magnor, Marcus

    2011-04-01

    We present a flexible interactive 3D morpho-kinematical modeling application for astrophysics. Compared to other systems, our application reduces the restrictions on the physical assumptions, data type, and amount that is required for a reconstruction of an object's morphology. It is one of the first publicly available tools to apply interactive graphics to astrophysical modeling. The tool allows astrophysicists to provide a priori knowledge about the object by interactively defining 3D structural elements. By direct comparison of model prediction with observational data, model parameters can then be automatically optimized to fit the observation. The tool has already been successfully used in a number of astrophysical research projects.

  8. Multiline Transfer and the Dynamics of Stellar Winds

    NASA Technical Reports Server (NTRS)

    Abbott, D. C.; Lucy, L. B.

    1985-01-01

    A Monte Carlo technique for treating multiline transfer in stellar winds is described. With a line list containing many thousands of transitions and with fairly realistic treatments of ionization, excitation and line formation, the resulting code allows the dynamic effects of overlapping lines the investigation of and provides the means to directly synthesize the complete spectrum of a star and its wind. It is found that the computed mass loss rate for data Puppis agrees with the observed rate. The synthesized spectrum of zeta Puppis also agrees with observational data. This confirms that line driving is the dominant acceleration mechanism in this star's wind.

  9. Relaxation of water infiltration pulses observed with GPR

    NASA Astrophysics Data System (ADS)

    Hantschel, Lisa; Hemmer, Benedikt; Roth, Kurt

    2017-04-01

    We observe the relaxation of infiltration pulses in sandy soil with ground-penetrating radar (GPR). The spatial distribution of water in the infiltration area and its temporal evolution is represented by ordinary reflections at layer boundaries as well as multiple reflections at the wetting front and the pulse boundaries. The structure of these highly resolved signals are reproduced by numerical simulations of electromagnetic wave propagation. The temporally highly resolved electrical fields reveal the origin also of complex reflection signals. The usage of these more complex signals might allow a more detailed representation of the infiltration process by direct analysis as well as in combination with inversion techniques.

  10. Dorsal light reflex is absent in the postural control system of the upside-down swimming catfish, Synodontis nigriventris

    NASA Astrophysics Data System (ADS)

    Ohnishi, T.; Ohnishi, K.; Okamoto, N.; Yamamoto, T.; Hosoi, H.; Takahashi, A.; Kawai, H.

    A kind of catfish, Synodontis nigriventris, has a unique habit of maintaining an upside-down posture under normal gravity conditions (1 G). We exposed S. nigriventris to a microgravity environment provided by the parabolic flights of an aircraft and observed the dorsal light reflex (DLR), which is well known to be an important visually guided postural reaction in fish. In general, fish directs its back to an illuminated direction, depending on DLR: DLR is observed more clearly under microgravity as compared with 1 G. Interestingly, S. nigriventris exhibited no DLR response even under microgravity. In contrast, clear DLR was observed under microgravity in two other species, which have an upside-up swimming habit, Synodontis multipunctatus, belonging to the same Synodontis family, and Corydoras paleatus, belonging to a different catfish family. Our parabolic flight experiments have confirmed for the first time that S. nigriventris has a novel balance sensation which does not induce DLR. This allows us to address a new and attractive strategy for the analysis of the postural control mechanism of vertebrate.

  11. The black hole symphony: probing new physics using gravitational waves.

    PubMed

    Gair, Jonathan R

    2008-12-13

    The next decade will very likely see the birth of a new field of astronomy as we become able to directly detect gravitational waves (GWs) for the first time. The existence of GWs is one of the key predictions of Einstein's theory of general relativity, but they have eluded direct detection for the last century. This will change thanks to a new generation of laser interferometers that are already in operation or which are planned for the near future. GW observations will allow us to probe some of the most exotic and energetic events in the Universe, the mergers of black holes. We will obtain information about the systems to a precision unprecedented in astronomy, and this will revolutionize our understanding of compact astrophysical systems. Moreover, if any of the assumptions of relativity theory are incorrect, this will lead to subtle, but potentially detectable, differences in the emitted GWs. Our observations will thus provide very precise verifications of the theory in an as yet untested regime. In this paper, I will discuss what GW observations could tell us about known and (potentially) unknown physics.

  12. Towards sub-nanometer real-space observation of spin and orbital magnetism at the Fe/MgO interface

    PubMed Central

    Thersleff, Thomas; Muto, Shunsuke; Werwiński, Mirosław; Spiegelberg, Jakob; Kvashnin, Yaroslav; Hjӧrvarsson, Björgvin; Eriksson, Olle; Rusz, Ján; Leifer, Klaus

    2017-01-01

    While the performance of magnetic tunnel junctions based on metal/oxide interfaces is determined by hybridization, charge transfer, and magnetic properties at the interface, there are currently only limited experimental techniques with sufficient spatial resolution to directly observe these effects simultaneously in real-space. In this letter, we demonstrate an experimental method based on Electron Magnetic Circular Dichroism (EMCD) that will allow researchers to simultaneously map magnetic transitions and valency in real-space over interfacial cross-sections with sub-nanometer spatial resolution. We apply this method to an Fe/MgO bilayer system, observing a significant enhancement in the orbital to spin moment ratio that is strongly localized to the interfacial region. Through the use of first-principles calculations, multivariate statistical analysis, and Electron Energy-Loss Spectroscopy (EELS), we explore the extent to which this enhancement can be attributed to emergent magnetism due to structural confinement at the interface. We conclude that this method has the potential to directly visualize spin and orbital moments at buried interfaces in magnetic systems with unprecedented spatial resolution. PMID:28338011

  13. Towards sub-nanometer real-space observation of spin and orbital magnetism at the Fe/MgO interface

    NASA Astrophysics Data System (ADS)

    Thersleff, Thomas; Muto, Shunsuke; Werwiński, Mirosław; Spiegelberg, Jakob; Kvashnin, Yaroslav; Hjӧrvarsson, Björgvin; Eriksson, Olle; Rusz, Ján; Leifer, Klaus

    2017-03-01

    While the performance of magnetic tunnel junctions based on metal/oxide interfaces is determined by hybridization, charge transfer, and magnetic properties at the interface, there are currently only limited experimental techniques with sufficient spatial resolution to directly observe these effects simultaneously in real-space. In this letter, we demonstrate an experimental method based on Electron Magnetic Circular Dichroism (EMCD) that will allow researchers to simultaneously map magnetic transitions and valency in real-space over interfacial cross-sections with sub-nanometer spatial resolution. We apply this method to an Fe/MgO bilayer system, observing a significant enhancement in the orbital to spin moment ratio that is strongly localized to the interfacial region. Through the use of first-principles calculations, multivariate statistical analysis, and Electron Energy-Loss Spectroscopy (EELS), we explore the extent to which this enhancement can be attributed to emergent magnetism due to structural confinement at the interface. We conclude that this method has the potential to directly visualize spin and orbital moments at buried interfaces in magnetic systems with unprecedented spatial resolution.

  14. The Jovian UV aurorae as seen by Juno-UVS

    NASA Astrophysics Data System (ADS)

    Bonfond, Bertrand; Gladstone, Randy; Grodent, Denis; Hue, Vincent; Gérard, Jean-Claude; Versteeg, Maarten; Greathouse, Thomas; Davis, Michael; Bolton, Scott; Levin, Steven; Connerney, John; Bagenal, Fran

    2017-04-01

    The Juno spacecraft was inserted in orbit around Jupiter on July 4th 2016. Its highly elongated polar orbit brings it <5000 km above the cloud tops every 53,5 days, allowing spectacular and unprecedented views of its polar aurorae. The Juno-UVS instrument is an imaging spectrograph observing perpendicularly to the Juno spin axis. It is equipped with a moving scan mirror at the entrance of the instrument that allows the field of view to be directed up to +/-30° away from the spin plane. The 70-205 nm bandpass comprises key UV auroral emissions such as the H2 bands and the H Lyman alpha line, as well as hydrocarbon absorption bands. We present polar maps of the aurorae at Jupiter for the first three first few periapses. These maps offer the first high resolution observations of the night-side aurorae. We will discuss the observed auroral morphology, including the satellite footprints, the outer emissions, the main emission and the polar emissions. We will also show maps of the color ratio, comparing the relative intensity of wavelengths subject to different degrees of absorption by CH4. Such measurements directly relate to the energy of the precipitating particles, since the more energetic the particles, the deeper they penetrate and the stronger the resulting methane absorption. For example, we will show evidence of longitudinal shifts between the brightness peaks and color ratio peaks in several auroral features. Such shifts may be interpreted as the result of the differential particle drift in plasma injection signatures.

  15. Observations of Fabric Development in Polycrystalline Ice at Basal Pressures: Methods and Initial Results

    NASA Astrophysics Data System (ADS)

    Breton, D. J.; Baker, I.; Cole, D. M.

    2012-12-01

    Understanding and predicting the flow of polycrystalline ice is crucial to ice sheet modeling and paleoclimate reconstruction from ice cores. Ice flow rates depend strongly on the fabric (i.e. the distribution of grain sizes and crystallographic orientations) which evolves over time and enhances the flow rate in the direction of applied stress. The mechanisms for fabric evolution in ice have been extensively studied at atmospheric pressures, but little work has been done to observe these processes at the high pressures experienced deep within ice sheets where long-term changes in ice rheology are expected to have significance. We conducted compressive creep tests on a 917 kg m-3 polycrystalline ice specimen at 20 MPa hydrostatic pressure, thus simulating ~2,000 m depth. Initial specimen grain orientations were random, typical grain diameters were 1.2 mm, and the applied creep stress was 0.3 MPa. Subsequent microstructural analyses on the deformed specimen and a similarly prepared, undeformed specimen allowed characterization of crystal fabric evolution under pressure. Our microstructural analysis technique simultaneously collected grain shape and size data from Scanning Electron Microscope (SEM) micrographs and obtained crystallographic orientation data via Electron BackScatter Diffraction (EBSD). Combining these measurements allows rapid analysis of the ice fabric over large numbers of grains, yielding statistically useful numbers of grain size and full c- and a-axis grain orientation data. The combined creep and microstructural data demonstrate pressure-dependent effects on the mechanical and microstructural evolution of polycrystalline ice. We discuss possible mechanisms for the observed phenomena, and future directions for hydrostatic creep testing.

  16. Matter-wave two-dimensional solitons in crossed linear and nonlinear optical lattices

    NASA Astrophysics Data System (ADS)

    da Luz, H. L. F.; Abdullaev, F. Kh.; Gammal, A.; Salerno, M.; Tomio, Lauro

    2010-10-01

    The existence of multidimensional matter-wave solitons in a crossed optical lattice (OL) with a linear optical lattice (LOL) in the x direction and a nonlinear optical lattice (NOL) in the y direction, where the NOL can be generated by a periodic spatial modulation of the scattering length using an optically induced Feshbach resonance is demonstrated. In particular, we show that such crossed LOLs and NOLs allow for stabilizing two-dimensional solitons against decay or collapse for both attractive and repulsive interactions. The solutions for the soliton stability are investigated analytically, by using a multi-Gaussian variational approach, with the Vakhitov-Kolokolov necessary criterion for stability; and numerically, by using the relaxation method and direct numerical time integrations of the Gross-Pitaevskii equation. Very good agreement of the results corresponding to both treatments is observed.

  17. HIGH DIMENSIONAL COVARIANCE MATRIX ESTIMATION IN APPROXIMATE FACTOR MODELS.

    PubMed

    Fan, Jianqing; Liao, Yuan; Mincheva, Martina

    2011-01-01

    The variance covariance matrix plays a central role in the inferential theories of high dimensional factor models in finance and economics. Popular regularization methods of directly exploiting sparsity are not directly applicable to many financial problems. Classical methods of estimating the covariance matrices are based on the strict factor models, assuming independent idiosyncratic components. This assumption, however, is restrictive in practical applications. By assuming sparse error covariance matrix, we allow the presence of the cross-sectional correlation even after taking out common factors, and it enables us to combine the merits of both methods. We estimate the sparse covariance using the adaptive thresholding technique as in Cai and Liu (2011), taking into account the fact that direct observations of the idiosyncratic components are unavailable. The impact of high dimensionality on the covariance matrix estimation based on the factor structure is then studied.

  18. Natural abundance 17O DNP NMR provides precise O–H distances and insights into the Brønsted acidity of heterogeneous catalysts

    DOE PAGES

    Perras, Frederic A.; Wang, Zhuoran; Naik, Pranjali; ...

    2017-05-12

    Heterogeneous Brønsted acid catalysts are tremendously important in industry, particularly in catalytic cracking processes. Here we show that these Brønsted acid sites can be directly observed at natural abundance by 17O DNP surface-enhanced NMR spectroscopy (SENS). We additionally show that the O–H bond length in these catalysts can be measured with sub-picometer precision, to enable a direct structural gauge of the lability of protons in a given material, which is correlated with the pH of the zero point of charge of the material. As a result, experiments performed on materials impregnated with pyridine also allow for the direct detection ofmore » intermolecular hydrogen bonding interactions through the lengthening of O–H bonds.« less

  19. Natural abundance 17O DNP NMR provides precise O–H distances and insights into the Brønsted acidity of heterogeneous catalysts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Perras, Frederic A.; Wang, Zhuoran; Naik, Pranjali

    Heterogeneous Brønsted acid catalysts are tremendously important in industry, particularly in catalytic cracking processes. Here we show that these Brønsted acid sites can be directly observed at natural abundance by 17O DNP surface-enhanced NMR spectroscopy (SENS). We additionally show that the O–H bond length in these catalysts can be measured with sub-picometer precision, to enable a direct structural gauge of the lability of protons in a given material, which is correlated with the pH of the zero point of charge of the material. As a result, experiments performed on materials impregnated with pyridine also allow for the direct detection ofmore » intermolecular hydrogen bonding interactions through the lengthening of O–H bonds.« less

  20. On the angular dependence of focused laser ablation by nanosecond pulses in solgel and polymer materials

    NASA Astrophysics Data System (ADS)

    George, D. S.; Onischenko, A.; Holmes, A. S.

    2004-03-01

    Focused laser ablation by single laser pulses at varying angles of incidence is studied in two materials of interest: a solgel (Ormocer 4) and a polymer (SU8). For a range of angles (up to 70° from normal), and for low-energy (<20 μJ), 40 ns pulses at 266 nm wavelength, the ablation depth along the direction of the incident laser beam is found to be independent of the angle of incidence. This allows the crater profiles at oblique incidence to be generated directly from the crater profiles at normal incidence by a simple coordinate transformation. This result is of use in the development of simulation tools for direct-write laser ablation. A simple model based on the moving ablation front approach is shown to be consistent with the observed behavior.

  1. Watching How Molecules Orient in a Surface Forces Apparatus, Using Confocal Raman Spectroscopy

    NASA Astrophysics Data System (ADS)

    Jiang, Shan; Kim, Minsu; Bae, Sung Chul; Granick, Steve

    2006-03-01

    Much is known about surface forces, less about where they come from. This laboratory is engaged in direct vibrational spectroscopic measurements of how molecules orient in confined geometries. Regarding force measurements, PDMS (polydimethylsiloxane) was a model system for many years. In this study, we describe direct experiments using a novel version of confocal Raman spectroscopy. This experiment allows direct measurement of how the PDMS molecules orient under confinment as well as under subsequent shear. When the thickness of the fluid film is less than the unperturbed radius of gyration of the polymer, we obtain two novel findings: (a) linewidth analysis of peaks reveals that vibrational relaxation times are perturbed in this confined geometry; (b) orientation of the chain backbone is not everywhere the same within the molecularly-thin film; domains of various orientation are observed instead.

  2. Direct-to-adolescent text messaging for vaccine reminders: What will parents permit?

    PubMed

    Roberts, James R; Morella, Kristen; Dawley, Erin H; Madden, Christi A; Jacobson, Robert M; Pope, Charlene; Davis, Boyd; Thompson, David; O'Brien, Elizabeth S; Darden, Paul M

    2018-05-11

    Direct-to-adolescent text messaging may be a consideration for vaccine reminders, including human papilloma virus (HPV), but no studies have explored the minimum age at which parents would allow adolescents to receive a text message. We distributed a survey to parents of 10-17 year olds during any office visit in two practice based research networks in South Carolina and Oklahoma. We asked about parental preference for receiving vaccine reminders for their adolescent, whether they would allow the healthcare provider to directly message their adolescent, and if so, what would be the acceptable minimum age. In 546 surveys from 11 practices, parents of females were more supportive of direct-to-teen text message reminders than were parents of males, (75% v. 60%, p < .001). The median age at which parents would allow direct text messages from physicians' offices was 14 in females compared to 15 in males, p = .049. We found a correlation between the child's age and the youngest age at which parents would allow a direct text message. Of the parents who permitted a text message directly to their adolescent, most reported an allowable age higher than their adolescent's current age until the age of 15. Our study suggests that direct-to-adolescent text messaging would be allowed by parents for older adolescents. This supports an intervention aimed at older adolescents, such as for receipt of MCV4 dose #2, delayed HPV vaccine series completion and annual influenza vaccination. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Tracing the transition of a macro electron shuttle into nonlinear response

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Chulki; Prada, Marta; Qin, Hua

    We present a study on a macroscopic electron shuttle in the transition from linear to nonlinear response. The shuttle consists of a classical mechanical pendulum situated between two capacitor plates. The metallic pendulum enables mechanical transfer of electrons between the plates, hence allowing to directly trace electron shuttling in the time domain. By applying a high voltage to the plates, we drive the system into a controlled nonlinear response, where we observe period doubling.

  4. Observation of methanol behavior in fuel cells in situ by NMR spectroscopy.

    PubMed

    Han, Oc Hee; Han, Kee Sung; Shin, Chang Woo; Lee, Juhee; Kim, Seong-Soo; Um, Myung Sup; Joh, Han-Ik; Kim, Soo-Kil; Ha, Heung Yong

    2012-04-16

    The chemical conversion of methanol in direct methanol fuel cells was followed in situ by NMR spectroscopy. Comparing data of the methanol oxidation on Pt and PtRu anode catalysts allowed the role of Ru in both Faradaic and non-Faradaic reactions to be investigated. The spatial distributions of chemicals could also be determined. (Picture: T1-T4=inlet and outlet tubes.). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Metal-poor stars. IV - The evolution of red giants.

    NASA Technical Reports Server (NTRS)

    Rood, R. T.

    1972-01-01

    Detailed evolutionary calculations for six Population-II red giants are presented. The first five of these models are followed from the zero age main sequence to the onset of the helium flash. The sixth model allows the effect of direct electron-neutrino interactions to be estimated. The updated input physics and evolutionary code are described briefly. The results of the calculations are presented in a manner pertinent to later stages of evolutions and suitable for comparison with observations.

  6. The validity of the ActiPed for physical activity monitoring.

    PubMed

    Brown, D K; Grimwade, D; Martinez-Bussion, D; Taylor, M J D; Gladwell, V F

    2013-05-01

    The ActiPed (FitLinxx) is a uniaxial accelerometer, which objectively measures physical activity, uploads the data wirelessly to a website, allowing participants and researchers to view activity levels remotely. The aim was to validate ActiPed's step count, distance travelled and activity time against direct observation. Further, to compare against pedometer (YAMAX), accelerometer (ActiGraph) and manufacturer's guidelines. 22 participants, aged 28±7 years, undertook 4 protocols, including walking on different surfaces and incremental running protocol (from 2 mph to 8 mph). Bland-Altman plots allowed comparison of direct observation against ActiPed estimates. For step count, the ActiPed showed a low % bias in all protocols: walking on a treadmill (-1.30%), incremental treadmill protocol (-1.98%), walking over grass (-1.67%), and walking over concrete (-0.93%). When differentiating between walking and running step count the ActiPed showed a % bias of 4.10% and -6.30%, respectively. The ActiPed showed >95% accuracy for distance and duration estimations overall, although underestimated distance (p<0.01) for walking over grass and concrete. Overall, the ActiPed showed acceptable levels of accuracy comparable to previous validated pedometers and accelerometers. The accuracy combined with the simple and informative remote gathering of data, suggests that the ActiPed could be a useful tool in objective physical activity monitoring. © Georg Thieme Verlag KG Stuttgart · New York.

  7. Multistimuli Response Micro- and Nanolayers of a Coordination Polymer Based on Cu2 I2 Chains Linked by 2-Aminopyrazine.

    PubMed

    Conesa-Egea, J; Gallardo-Martínez, J; Delgado, S; Martínez, J I; Gonzalez-Platas, J; Fernández-Moreira, V; Rodríguez-Mendoza, U R; Ocón, P; Zamora, F; Amo-Ochoa, P

    2017-09-01

    A nonporous laminar coordination polymer of formula [Cu 2 I 2 (2-aminopyrazine)] n is prepared by direct reaction between CuI and 2-aminopyrazine, two industrially available building blocks. The fine tuning of the reaction conditions allows obtaining [Cu 2 I 2 (2-aminopyrazine)] n in micrometric and nanometric sizes with same structure and composition. Interestingly, both materials show similar reversible thermo- and pressure-luminescent response as well as reversible electrical response to volatile organic solvents such as acetic acid. X-ray diffraction studies under different conditions, temperatures and pressures, in combination with theoretical calculations allow rationalizing the physical properties of this compound and its changes under physical stimuli. Thus, the emission dramatically increases when lowering the temperature, while an enhancement of the pressure produces a decrease in the emission intensity. These observations emerge as a direct consequence of the high structural flexibility of the Cu 2 I 2 chains which undergo a contraction in CuCu distances as far as temperature decreases or pressure increases. However, the strong structural changes observed under high pressure lead to an unexpected effect that produces a less effective CuCu orbital overlapping that justifies the decrease in the intensity emission. This work shows the high potential of materials based on Cu 2 I 2 chains for new applications. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. The physical origin of the X-ray emission from SN 1987A

    NASA Astrophysics Data System (ADS)

    Miceli, M.; Orlando, S.; Petruk, O.

    2017-10-01

    We revisit the spectral analysis of the set of archive XMM-Newton observations of SN 1987A through our 3-D hydrodynamic model describing the whole evolution from the onset of the supernova to the full remnant development. For the first time the spectral analysis accounts for the single observations and for the evolution of the system self-consistently. We adopt a forward modeling approach which allows us to directly synthesize, from the model, X-ray spectra and images in different energy bands. We fold the synthetic observables through the XMM-Newton instrumental response and directly compare models and actual data. We find that our simulation provides an excellent fit to the data, by reproducing simultaneously X-ray fluxes, spectral features, and morphology of SN 1987A at all evolutionary stages. Our analysis enables us to obtain a deep insight on the physical origin of the observed multi-thermal emission, by revealing the contribution of shocked surrounding medium, dense clumps of the circumstellar ring, and ejecta to the total emission. We finally provide predictions for future observations (to be performed with XMM-Newton in the next future and with the forthcoming Athena X-ray telescope in approximately 10 years), showing the growing contribution of the ejecta X-ray emission.

  9. Solving the relativistic inverse stellar problem through gravitational waves observation of binary neutron stars

    NASA Astrophysics Data System (ADS)

    Abdelsalhin, Tiziano; Maselli, Andrea; Ferrari, Valeria

    2018-04-01

    The LIGO/Virgo Collaboration has recently announced the direct detection of gravitational waves emitted in the coalescence of a neutron star binary. This discovery allows, for the first time, to set new constraints on the behavior of matter at supranuclear density, complementary with those coming from astrophysical observations in the electromagnetic band. In this paper we demonstrate the feasibility of using gravitational signals to solve the relativistic inverse stellar problem, i.e., to reconstruct the parameters of the equation of state (EoS) from measurements of the stellar mass and tidal Love number. We perform Bayesian inference of mock data, based on different models of the star internal composition, modeled through piecewise polytropes. Our analysis shows that the detection of a small number of sources by a network of advanced interferometers would allow to put accurate bounds on the EoS parameters, and to perform a model selection among the realistic equations of state proposed in the literature.

  10. Complete reduction of high-density UO2 to metallic U in molten Li2O-LiCl

    NASA Astrophysics Data System (ADS)

    Choi, Eun-Young; Lee, Jeong

    2017-10-01

    The large size and high density of spent fuel pellets make it difficult to use the pellets directly in electrolytic reduction (also called as oxide reduction, OR) for pyroprocessing owing to the slow diffusion of molten Li2O-LiCl salt electrolyte into the pellets. In this study, we investigated complete OR of high-density UO2 to metallic U without any remaining UO2. Only partial reductions near the surface of high-density UO2 pellets were observed under operation conditions employing fast electrolysis rate that allowed previously complete reduction of low-density UO2 pellets. Complete reduction of high-density UO2 pellets was observed at fast electrolysis rate when the pellet size was reduced. The complete reduction of high-density UO2 pellets without size reduction was achieved at slow electrolysis rate, which allowed sufficient chemical reduction of UO2 with the lithium metal generated by the cathode reaction.

  11. Unravelling surface and interfacial structures of a metal-organic framework by transmission electron microscopy.

    PubMed

    Zhu, Yihan; Ciston, Jim; Zheng, Bin; Miao, Xiaohe; Czarnik, Cory; Pan, Yichang; Sougrat, Rachid; Lai, Zhiping; Hsiung, Chia-En; Yao, Kexin; Pinnau, Ingo; Pan, Ming; Han, Yu

    2017-05-01

    Metal-organic frameworks (MOFs) are crystalline porous materials with designable topology, porosity and functionality, having promising applications in gas storage and separation, ion conduction and catalysis. It is challenging to observe MOFs with transmission electron microscopy (TEM) due to the extreme instability of MOFs upon electron beam irradiation. Here, we use a direct-detection electron-counting camera to acquire TEM images of the MOF ZIF-8 with an ultralow dose of 4.1 electrons per square ångström to retain the structural integrity. The obtained image involves structural information transferred up to 2.1 Å, allowing the resolution of individual atomic columns of Zn and organic linkers in the framework. Furthermore, TEM reveals important local structural features of ZIF-8 crystals that cannot be identified by diffraction techniques, including armchair-type surface terminations and coherent interfaces between assembled crystals. These observations allow us to understand how ZIF-8 crystals self-assemble and the subsequent influence of interfacial cavities on mass transport of guest molecules.

  12. Unravelling surface and interfacial structures of a metal-organic framework by transmission electron microscopy

    NASA Astrophysics Data System (ADS)

    Zhu, Yihan; Ciston, Jim; Zheng, Bin; Miao, Xiaohe; Czarnik, Cory; Pan, Yichang; Sougrat, Rachid; Lai, Zhiping; Hsiung, Chia-En; Yao, Kexin; Pinnau, Ingo; Pan, Ming; Han, Yu

    2017-05-01

    Metal-organic frameworks (MOFs) are crystalline porous materials with designable topology, porosity and functionality, having promising applications in gas storage and separation, ion conduction and catalysis. It is challenging to observe MOFs with transmission electron microscopy (TEM) due to the extreme instability of MOFs upon electron beam irradiation. Here, we use a direct-detection electron-counting camera to acquire TEM images of the MOF ZIF-8 with an ultralow dose of 4.1 electrons per square ångström to retain the structural integrity. The obtained image involves structural information transferred up to 2.1 Å, allowing the resolution of individual atomic columns of Zn and organic linkers in the framework. Furthermore, TEM reveals important local structural features of ZIF-8 crystals that cannot be identified by diffraction techniques, including armchair-type surface terminations and coherent interfaces between assembled crystals. These observations allow us to understand how ZIF-8 crystals self-assemble and the subsequent influence of interfacial cavities on mass transport of guest molecules.

  13. Biases and systematics in the observational derivation of galaxy properties: comparing different techniques on synthetic observations of simulated galaxies

    NASA Astrophysics Data System (ADS)

    Guidi, Giovanni; Scannapieco, Cecilia; Walcher, C. Jakob

    2015-12-01

    We study the sources of biases and systematics in the derivation of galaxy properties from observational studies, focusing on stellar masses, star formation rates, gas and stellar metallicities, stellar ages, magnitudes and colours. We use hydrodynamical cosmological simulations of galaxy formation, for which the real quantities are known, and apply observational techniques to derive the observables. We also analyse biases that are relevant for a proper comparison between simulations and observations. For our study, we post-process the simulation outputs to calculate the galaxies' spectral energy distributions (SEDs) using stellar population synthesis models and also generate the fully consistent far-UV-submillimetre wavelength SEDs with the radiative transfer code SUNRISE. We compared the direct results of simulations with the observationally derived quantities obtained in various ways, and found that systematic differences in all studied galaxy properties appear, which are caused by: (1) purely observational biases, (2) the use of mass-weighted and luminosity-weighted quantities, with preferential sampling of more massive and luminous regions, (3) the different ways of constructing the template of models when a fit to the spectra is performed, and (4) variations due to different calibrations, most notably for gas metallicities and star formation rates. Our results show that large differences can appear depending on the technique used to derive galaxy properties. Understanding these differences is of primary importance both for simulators, to allow a better judgement of similarities and differences with observations, and for observers, to allow a proper interpretation of the data.

  14. Cross-Scale Observational Signatures of Magnetic Reconnection

    NASA Technical Reports Server (NTRS)

    Savage, Sabrina; Malaspina, David

    2014-01-01

    Magnetic reconnection is a significant mechanism for energy release across many astrophysical applications. In the solar atmosphere, reconnection is considered a primary contributor of flare evolution and coronal heating. Directly observing reconnection occurring in the solar atmosphere, however, is not trivial considering that the scale size of the diffusion region is magnitudes smaller than the observational capabilities of current instrumentation, and coronal magnetic field measurements are not currently sufficient to capture the process. Meanwhile, reconnection occurring in the Earth's magnetosphere transfers energy from the solar wind through a comparable process, although on vastly different scales. Magnetospheric measurements are made in situ rather than remotely; ergo, comparison of observations between the two regimes allows for potentially significant insight into reconnection as a stochastic and possibly turbulent process. We will present a set of observations from long-duration solar events and compare them to in situ measurements from the magnetosphere.

  15. Cross-scale Observational Signatures of Magnetic Reconnection

    NASA Astrophysics Data System (ADS)

    Savage, S. L.; Malaspina, D.

    2014-12-01

    Magnetic reconnection is a significant mechanism for energy release across many astrophysical applications. In the solar atmosphere, reconnection is considered a primary contributor of flare evolution and coronal heating. Directly observing reconnection occurring in the solar atmosphere, however, is not trivial considering that the scale size of the diffusion region is magnitudes smaller than the observational capabilities of current instrumentation, and coronal magnetic field measurements are not currently sufficient to capture the process. Meanwhile, reconnection occurring in the Earth's magnetosphere transfers energy from the solar wind through a comparable process, although on vastly different scales. Magnetospheric measurements are made in situ rather than remotely; ergo, comparison of observations between the two regimes allows for potentially significant insight into reconnection as a stochastic and possibly turbulent process. We will present a set of observations from long-duration solar events and compare them to in situ measurements from the magnetosphere.

  16. NEO follow-up, recovery and precovery campaigns at the ESA NEO Coordination Centre

    NASA Astrophysics Data System (ADS)

    Micheli, Marco; Koschny, Detlef; Drolshagen, Gerhard; Perozzi, Ettore; Borgia, Barbara

    2016-01-01

    The NEO Coordination Centre (NEOCC) has been established within the framework of the ESA Space Situational Awareness (SSA) Programme. Among its tasks are the coordination of observational activities and the distribution of up-to-date information on NEOs through its web portal. The Centre is directly involved in observational campaigns with various telescopes, including ESO's VLT and ESA's OGS telescope. We are also developing a network of collaborating observatories, with a variety of capabilities, which are alerted when an important observational opportunity arises. From a service perspective, the system hosted at the NEOCC collects information on NEOs produced by European services and makes it available to users, with a focus on objects with possible collisions with the Earth. Among the tools provided via our portal are the Risk List of all known NEOs with impact solutions, and the Priority List, which allows observers to identify NEOs in most urgent need of observations.

  17. BoolFilter: an R package for estimation and identification of partially-observed Boolean dynamical systems.

    PubMed

    Mcclenny, Levi D; Imani, Mahdi; Braga-Neto, Ulisses M

    2017-11-25

    Gene regulatory networks govern the function of key cellular processes, such as control of the cell cycle, response to stress, DNA repair mechanisms, and more. Boolean networks have been used successfully in modeling gene regulatory networks. In the Boolean network model, the transcriptional state of each gene is represented by 0 (inactive) or 1 (active), and the relationship among genes is represented by logical gates updated at discrete time points. However, the Boolean gene states are never observed directly, but only indirectly and incompletely through noisy measurements based on expression technologies such as cDNA microarrays, RNA-Seq, and cell imaging-based assays. The Partially-Observed Boolean Dynamical System (POBDS) signal model is distinct from other deterministic and stochastic Boolean network models in removing the requirement of a directly observable Boolean state vector and allowing uncertainty in the measurement process, addressing the scenario encountered in practice in transcriptomic analysis. BoolFilter is an R package that implements the POBDS model and associated algorithms for state and parameter estimation. It allows the user to estimate the Boolean states, network topology, and measurement parameters from time series of transcriptomic data using exact and approximated (particle) filters, as well as simulate the transcriptomic data for a given Boolean network model. Some of its infrastructure, such as the network interface, is the same as in the previously published R package for Boolean Networks BoolNet, which enhances compatibility and user accessibility to the new package. We introduce the R package BoolFilter for Partially-Observed Boolean Dynamical Systems (POBDS). The BoolFilter package provides a useful toolbox for the bioinformatics community, with state-of-the-art algorithms for simulation of time series transcriptomic data as well as the inverse process of system identification from data obtained with various expression technologies such as cDNA microarrays, RNA-Seq, and cell imaging-based assays.

  18. Boltzmann babies in the proper time measure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bousso, Raphael; Freivogel, Ben; Yang, I-S.

    2008-05-15

    After commenting briefly on the role of the typicality assumption in science, we advocate a phenomenological approach to the cosmological measure problem. Like any other theory, a measure should be simple, general, well defined, and consistent with observation. This allows us to proceed by elimination. As an example, we consider the proper time cutoff on a geodesic congruence. It predicts that typical observers are quantum fluctuations in the early universe, or Boltzmann babies. We sharpen this well-known youngness problem by taking into account the expansion and open spatial geometry of pocket universes. Moreover, we relate the youngness problem directly tomore » the probability distribution for observables, such as the temperature of the cosmic background radiation. We consider a number of modifications of the proper time measure, but find none that would make it compatible with observation.« less

  19. Observation of quantum oscillation of work function in ultrathin-metal/semiconductor junctions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Takhar, Kuldeep; Meer, Mudassar; Khachariya, Dolar

    2015-09-15

    Quantization in energy level due to confinement is generally observed for semiconductors. This property is used for various quantum devices, and it helps to improve the characteristics of conventional devices. Here, the authors have demonstrated the quantum size effects in ultrathin metal (Ni) layers sandwiched between two large band-gap materials. The metal work function is found to oscillate as a function of its thickness. The thermionic emission current bears the signature of the oscillating work function, which has a linear relationship with barrier heights. This methodology allows direct observation of quantum oscillations in metals at room temperature using a Schottkymore » diode and electrical measurements using source-measure-units. The observed phenomena can provide additional mechanism to tune the barrier height of metal/semiconductor junctions, which are used for various electronic devices.« less

  20. Boltzmann babies in the proper time measure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bousso, Raphael; Bousso, Raphael; Freivogel, Ben

    After commenting briefly on the role of the typicality assumption in science, we advocate a phenomenological approach to the cosmological measure problem. Like any other theory, a measure should be simple, general, well defined, and consistent with observation. This allows us to proceed by elimination. As an example, we consider the proper time cutoff on a geodesic congruence. It predicts that typical observers are quantum fluctuations in the early universe, or Boltzmann babies. We sharpen this well-known youngness problem by taking into account the expansion and open spatial geometry of pocket universes. Moreover, we relate the youngness problem directly tomore » the probability distribution for observables, such as the temperature of the cosmic background radiation. We consider a number of modifications of the proper time measure, but find none that would make it compatible with observation.« less

  1. A portable anaerobic microbioreactor reveals optimum growth conditions for the methanogen Methanosaeta concilii.

    PubMed

    Steinhaus, Benjamin; Garcia, Marcelo L; Shen, Amy Q; Angenent, Largus T

    2007-03-01

    Conventional studies of the optimum growth conditions for methanogens (methane-producing, obligate anaerobic archaea) are typically conducted with serum bottles or bioreactors. The use of microfluidics to culture methanogens allows direct microscopic observations of the time-integrated response of growth. Here, we developed a microbioreactor (microBR) with approximately 1-microl microchannels to study some optimum growth conditions for the methanogen Methanosaeta concilii. The microBR is contained in an anaerobic chamber specifically designed to place it directly onto an inverted light microscope stage while maintaining a N2-CO2 environment. The methanogen was cultured for months inside microchannels of different widths. Channel width was manipulated to create various fluid velocities, allowing the direct study of the behavior and responses of M. concilii to various shear stresses and revealing an optimum shear level of approximately 20 to 35 microPa. Gradients in a single microchannel were then used to find an optimum pH level of 7.6 and an optimum total NH4-N concentration of less than 1,100 mg/liter (<47 mg/liter as free NH3-N) for M. concilii under conditions of the previously determined ideal shear stress and pH and at a temperature of 35 degrees C.

  2. A revised ground-motion and intensity interpolation scheme for shakemap

    USGS Publications Warehouse

    Worden, C.B.; Wald, D.J.; Allen, T.I.; Lin, K.; Garcia, D.; Cua, G.

    2010-01-01

    We describe a weighted-average approach for incorporating various types of data (observed peak ground motions and intensities and estimates from groundmotion prediction equations) into the ShakeMap ground motion and intensity mapping framework. This approach represents a fundamental revision of our existing ShakeMap methodology. In addition, the increased availability of near-real-time macroseismic intensity data, the development of newrelationships between intensity and peak ground motions, and new relationships to directly predict intensity from earthquake source information have facilitated the inclusion of intensity measurements directly into ShakeMap computations. Our approach allows for the combination of (1) direct observations (ground-motion measurements or reported intensities), (2) observations converted from intensity to ground motion (or vice versa), and (3) estimated ground motions and intensities from prediction equations or numerical models. Critically, each of the aforementioned data types must include an estimate of its uncertainties, including those caused by scaling the influence of observations to surrounding grid points and those associated with estimates given an unknown fault geometry. The ShakeMap ground-motion and intensity estimates are an uncertainty-weighted combination of these various data and estimates. A natural by-product of this interpolation process is an estimate of total uncertainty at each point on the map, which can be vital for comprehensive inventory loss calculations. We perform a number of tests to validate this new methodology and find that it produces a substantial improvement in the accuracy of ground-motion predictions over empirical prediction equations alone.

  3. Numerical Simulations of Slow Stick Slip Events with PFC, a DEM Based Code

    NASA Astrophysics Data System (ADS)

    Ye, S. H.; Young, R. P.

    2017-12-01

    Nonvolcanic tremors around subduction zone have become a fascinating subject in seismology in recent years. Previous studies have shown that the nonvolcanic tremor beneath western Shikoku is composed of low frequency seismic waves overlapping each other. This finding provides direct link between tremor and slow earthquakes. Slow stick slip events are considered to be laboratory scaled slow earthquakes. Slow stick slip events are traditionally studied with direct shear or double direct shear experiment setup, in which the sliding velocity can be controlled to model a range of fast and slow stick slips. In this study, a PFC* model based on double direct shear is presented, with a central block clamped by two side blocks. The gauge layers between the central and side blocks are modelled as discrete fracture networks with smooth joint bonds between pairs of discrete elements. In addition, a second model is presented in this study. This model consists of a cylindrical sample subjected to triaxial stress. Similar to the previous model, a weak gauge layer at a 45 degrees is added into the sample, on which shear slipping is allowed. Several different simulations are conducted on this sample. While the confining stress is maintained at the same level in different simulations, the axial loading rate (displacement rate) varies. By varying the displacement rate, a range of slipping behaviour, from stick slip to slow stick slip are observed based on the stress-strain relationship. Currently, the stick slip and slow stick slip events are strictly observed based on the stress-strain relationship. In the future, we hope to monitor the displacement and velocity of the balls surrounding the gauge layer as a function of time, so as to generate a synthetic seismogram. This will allow us to extract seismic waveforms and potentially simulate the tremor-like waves found around subduction zones. *Particle flow code, a discrete element method based numerical simulation code developed by Itasca Inc.

  4. Concurrent Activation of Striatal Direct and Indirect Pathways During Action Initiation

    PubMed Central

    Cui, Guohong; Jun, Sang Beom; Jin, Xin; Pham, Michael D.

    2014-01-01

    Summary The basal ganglia are subcortical nuclei that control voluntary actions, and are affected by a number of debilitating neurological disorders1–4. The prevailing model of basal ganglia function proposes that two orthogonal projection circuits originating from distinct populations of spiny projection neurons (SPNs) in the striatum5,6 - the so-called direct and indirect pathways - have opposing effects on movement: while activity of direct-pathway SPNs purportedly facilitates movement, activity of indirect-pathway SPNs inhibits movement1,2. This model has been difficult to test due to the lack of methods to selectively measure the activity of direct- and indirect-pathway SPNs in freely moving animals. We developed a novel in-vivo method that allowed us to specifically measure direct- and indirect-pathway SPN activity using Cre-dependent viral expression of the genetically encoded calcium indicator (GECI) GCAMP3 in the dorsal striatum of D1-Cre (direct-pathway specific6,7) and A2A-Cre (indirect-pathway specific8,9) mice10. Using fiber optics and time-correlated single photon counting (TCSPC) in mice performing an operant task, we observed transient increases in neural activity in both direct- and indirect-pathway SPNs when animals initiated actions, but not when they were inactive. Concurrent activation of SPNs from both pathways in one hemisphere preceded the initiation of contraversive movements, and predicted the occurrence of specific movements within 500 ms. These observations challenge the classical view of basal ganglia function, and may have implications for understanding the origin of motor symptoms in basal ganglia disorders. PMID:23354054

  5. Nonadiabatic laser-induced alignment of molecules: Reconstructing ⟨ θ⟩ directly from ⟨ θ2D⟩ by Fourier analysis.

    PubMed

    Søndergaard, Anders Aspegren; Shepperson, Benjamin; Stapelfeldt, Henrik

    2017-07-07

    We present an efficient, noise-robust method based on Fourier analysis for reconstructing the three-dimensional measure of the alignment degree, ⟨cos 2 θ⟩, directly from its two-dimensional counterpart, ⟨cos 2 θ 2D ⟩. The method applies to nonadiabatic alignment of linear molecules induced by a linearly polarized, nonresonant laser pulse. Our theoretical analysis shows that the Fourier transform of the time-dependent ⟨cos 2 θ 2D ⟩ trace over one molecular rotational period contains additional frequency components compared to the Fourier transform of ⟨cos 2 θ⟩. These additional frequency components can be identified and removed from the Fourier spectrum of ⟨cos 2 θ 2D ⟩. By rescaling of the remaining frequency components, the Fourier spectrum of ⟨cos 2 θ⟩ is obtained and, finally, ⟨cos 2 θ⟩ is reconstructed through inverse Fourier transformation. The method allows the reconstruction of the ⟨cos 2 θ⟩ trace from a measured ⟨cos 2 θ 2D ⟩ trace, which is the typical observable of many experiments, and thereby provides direct comparison to calculated ⟨cos 2 θ⟩ traces, which is the commonly used alignment metric in theoretical descriptions. We illustrate our method by applying it to the measurement of nonadiabatic alignment of I 2 molecules. In addition, we present an efficient algorithm for calculating the matrix elements of cos 2 θ 2D and any other observable in the symmetric top basis. These matrix elements are required in the rescaling step, and they allow for highly efficient numerical calculation of ⟨cos 2 θ 2D ⟩ and ⟨cos 2 θ⟩ in general.

  6. Theoretical aspects for estimating anisotropic saturated hydraulic conductivity from in-well or direct-push probe injection tests in uniform media

    NASA Astrophysics Data System (ADS)

    Klammler, Harald; Layton, Leif; Nemer, Bassel; Hatfield, Kirk; Mohseni, Ana

    2017-06-01

    Hydraulic conductivity and its anisotropy are fundamental aquifer properties for groundwater flow and transport modeling. Current in-well or direct-push field measurement techniques allow for relatively quick determination of general conductivity profiles with depth. However, capabilities for identifying local scale conductivities in the horizontal and vertical directions are very limited. Here, we develop the theoretical basis for estimating horizontal and vertical conductivities from different types of steady-state single-well/probe injection tests under saturated conditions and in the absence of a well skin. We explore existing solutions and a recent semi-analytical solution approach to the flow problem under the assumption that the aquifer is locally homogeneous. The methods are based on the collection of an additional piece of information in the form of a second injection (or recirculation) test at a same location, or in the form of an additional head or flow observation along the well/probe. Results are represented in dimensionless charts for partial validation against approximate solutions and for practical application to test interpretation. The charts further allow for optimization of a test configuration to maximize sensitivity to anisotropy ratio. The two methods most sensitive to anisotropy are found to be (1) subsequent injection from a lateral screen and from the bottom of an otherwise cased borehole, and (2) single injection from a lateral screen with an additional head observation along the casing. Results may also be relevant for attributing consistent divergences in conductivity measurements from different testing methods applied at a same site or location to the potential effects of anisotropy. Some practical aspects are discussed and references are made to existing methods, which appear easily compatible with the proposed procedures.

  7. Observation of Spin Polarons in a Tunable Fermi Liquid of Ultracold Atoms

    NASA Astrophysics Data System (ADS)

    Zwierlein, Martin

    2009-05-01

    We have observed spin polarons, dressed spin down impurities in a spin up Fermi sea of ultracold atoms via tomographic RF spectroscopy. Feshbach resonances allow to freely tune the interactions between the two spin states involved. A single spin down atom immersed in a Fermi sea of spin up atoms can do one of two things: For strong attraction, it can form a molecule with exactly one spin up partner, but for weaker interaction it will spread its attraction and surround itself with a collection of majority atoms. This spin down atom dressed with a spin up cloud constitutes the spin- or Fermi polaron. We have observed a striking spectroscopic signature of this quasi-particle for various interaction strengths, a narrow peak in the spin down spectrum that emerges above a broad background. The spectra allow us to directly measure the polaron energy and the quasi-particle residue Z. The polarons are found to be only weakly interacting with each other, and can thus be identified with the quasi-particles of Landau's Fermi liquid theory. At a critical interaction strength, we observe a transition from spin one-half polarons to spin zero molecules. At this point the Fermi liquid undergoes a phase transition into a superfluid Bose liquid.

  8. Collective conflict resolution in groups on the move

    NASA Astrophysics Data System (ADS)

    Pinkoviezky, Itai; Couzin, Iain D.; Gov, Nir S.

    2018-03-01

    Collective decision-making regarding direction of travel is observed during natural motion of animal and cellular groups. This phenomenon is exemplified, in the simplest case, by a group that contains two informed subgroups that hold conflicting preferred directions of motion. Under such circumstances, simulations, subsequently supported by experimental data with birds and primates, have demonstrated that the resulting motion is either towards a compromise direction or towards one of the preferred targets (even when the two subgroups are equal in size). However, the nature of this transition is not well understood. We present a theoretical study that combines simulations and a spin model for mobile animal groups, the latter providing an equilibrium representation, and exact solution in the thermodynamic limit. This allows us to identify the nature of this transition at a critical angular difference between the two preferred directions: in both flocking and spin models the transition coincides with the change in the group dynamics from Brownian to persistent collective motion. The groups undergo this transition as the number of uninformed individuals (those in the group that do not exhibit a directional preference) increases, which acts as an inverse of the temperature (noise) of the spin model. When the two informed subgroups are not equal in size, there is a tendency for the group to reach the target preferred by the larger subgroup. We find that the spin model captures effectively the essence of the collective decision-making transition and allows us to reveal a noise-dependent trade-off between the decision-making speed and the ability to achieve majority (democratic) consensus.

  9. Collective conflict resolution in groups on the move.

    PubMed

    Pinkoviezky, Itai; Couzin, Iain D; Gov, Nir S

    2018-03-01

    Collective decision-making regarding direction of travel is observed during natural motion of animal and cellular groups. This phenomenon is exemplified, in the simplest case, by a group that contains two informed subgroups that hold conflicting preferred directions of motion. Under such circumstances, simulations, subsequently supported by experimental data with birds and primates, have demonstrated that the resulting motion is either towards a compromise direction or towards one of the preferred targets (even when the two subgroups are equal in size). However, the nature of this transition is not well understood. We present a theoretical study that combines simulations and a spin model for mobile animal groups, the latter providing an equilibrium representation, and exact solution in the thermodynamic limit. This allows us to identify the nature of this transition at a critical angular difference between the two preferred directions: in both flocking and spin models the transition coincides with the change in the group dynamics from Brownian to persistent collective motion. The groups undergo this transition as the number of uninformed individuals (those in the group that do not exhibit a directional preference) increases, which acts as an inverse of the temperature (noise) of the spin model. When the two informed subgroups are not equal in size, there is a tendency for the group to reach the target preferred by the larger subgroup. We find that the spin model captures effectively the essence of the collective decision-making transition and allows us to reveal a noise-dependent trade-off between the decision-making speed and the ability to achieve majority (democratic) consensus.

  10. Observation of improved and degraded confinement with driven flow on the LAPD

    NASA Astrophysics Data System (ADS)

    Schaffner, David

    2012-10-01

    External continuous control over azimuthal flow and flow shear has been achieved in a linear plasma device for the first time allowing for a careful study of the effect of flow shear on pressure-gradient-driven turbulence and transport in the edge of the Large Plasma Device (LAPD). The flow is controlled using biasable iris-like limiters situated axially between the cathode source and main plasma chamber. LAPD rotates spontaneously in the ion diamagnetic direction (IDD); positive limiter bias first reduces, then minimizes (producing a near-zero shear state), and finally reverses the flow into the electron diamagnetic direction (EDD). Degradation of particle confinement is observed in the minimum shearing state and reduction in turbulent particle flux is observed with increasing shearing in both flow directions. Near-complete suppression of turbulent particle flux is observed for shearing rates comparable to the turbulent autocorrelation rate measured in the minimum shear state. Turbulent flux suppression is dominated by amplitude reduction in low-frequency (>10kHz) density fluctuations and a reduction in the radial correlation length. An increase in fluctuations for the highest shearing states is observed with the emergence of a coherent mode which does not lead to net particle transport. Magnetic field is varied in order to explore whether and how field effects transport modification. Calculations of transport equations are used to predict density profiles given source and temperature profiles and can show the level of transport predicted to be necessary in order to produce the experimental density profiles observed. Finally, the variations of density fluctuations and radial correlation length are fit well with power-laws and compare favorably to simple models of shear suppression of transport.

  11. In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow

    PubMed Central

    Lo Celso, Cristina; Lin, Charles P; Scadden, David T

    2011-01-01

    In vivo imaging of transplanted hematopoietic stem and progenitor cells (HSPCs) was developed to investigate the relationship between HSPCs and components of their microenvironment in the bone marrow. In particular, it allows a direct observation of the behavior of hematopoietic cells during the first few days after transplantation, when the critical events in homing and early engraftment are occurring. By directly imaging these events in living animals, this method permits a detailed assessment of functions previously evaluated by crude assessments of cell counts (homing) or after prolonged periods (engraftment). This protocol offers a new means of investigating the role of cell-intrinsic and cell-extrinsic molecular regulators of hematopoiesis during the early stages of transplantation, and it is the first to allow the study of cell-cell interactions within the bone marrow in three dimensions and in real time. In this paper, we describe how to isolate, label and inject HSPCs, as well as how to perform calvarium intravital microscopy and analyze the resulting images. A typical experiment can be performed and analyzed in ~1 week. PMID:21212779

  12. Probing Buffer-Gas Cooled Molecules with Direct Frequency Comb Spectroscopy in the Mid-Infrrared

    NASA Astrophysics Data System (ADS)

    Spaun, Ben; Changala, Bryan; Bjork, Bryce J.; Heckl, Oliver H.; Patterson, David; Doyle, John M.; Ye, Jun

    2015-06-01

    We present the first demonstration of cavity-enhanced direct frequency comb spectroscopy on buffer-gas cooled molecules.By coupling a mid-infrared frequency comb to a high-finesse cavity surrounding a helium buffer-gas chamber, we can gather rotationally resolved absorption spectra with high sensitivity over a broad wavelength region. The measured ˜10 K rotational and translational temperatures of buffer-gas cooled molecules drastically simplify the observed spectra, compared to those of room temperature molecules, and allow for high spectral resolution limited only by Doppler broadening (10-100 MHz). Our system allows for the extension of high-resolution spectroscopy to larger molecules, enabling detailed analysis of molecular structure and dynamics, while taking full advantage of the powerful optical properties of frequency combs. A. Foltynowicz et al. Cavity-enhanced optical frequency comb spectroscopy in the mid-infrared application to trace detection of hydrogen peroxide. Applied Physics B, vol. 110, pp. 163-175, 2013. {D. Patterson and J. M. Doyle. Cooling molecules in a cell for FTMW spectroscopy. Molecular Physics 110, 1757-1766, 2012

  13. EarthObserver: Bringing the world to your fingertips

    NASA Astrophysics Data System (ADS)

    Ryan, W. B.; Goodwillie, A. M.; Coplan, J.; Carbotte, S. M.; Arko, R. A.; Ferrini, V.; O'hara, S. H.; Chan, S.; Bonczkowski, J.; Nitsche, F. O.; Morton, J. J.; McLain, K.; Weissel, R.

    2011-12-01

    EarthObserver (http://www.earth-observer.org/), developed by the Lamont-Doherty Earth Observatory of Columbia University, brings a wealth of geoscience data to Apple iPad, iPhone and iPod Touch mobile devices. Built around an easy-to-use interface, EarthObserver allows users to explore and visualise a wide range of data sets superimposed upon a detailed base map of land elevations and ocean depths - tapping the screen will instantly return the height or depth at that point. A simple transparency function allows direct comparison of built-in content. Data sets include high-resolution coastal bathymetry of bays, sounds, estuaries, harbors and rivers; geological maps of the US states and world - tapping the screen displays the rock type, and full legends can be viewed; US Topo sheets; and, geophysical content including seafloor crustal age and sediment thickness, earthquake and volcano data, gravity and magnetic anomalies, and plate boundary descriptions. The names of physiographic features are automatically displayed. NASA Visible Earth images along with ocean temperature, salinity and productivity maps and precipitation information expose data sets of interest to the atmospheric, oceanic and biological communities. Natural hazard maps, population information and political boundaries allow users to explore impacts upon society. EarthObserver, so far downloaded by more than 55,000 users, offers myriad ways for educators at all levels to bring research-quality geoscience data into the learning environment, whether for use as an in-class illustration or for extensive exploration of earth sciences data. By using cutting-edge mobile app technology, EarthObserver boosts access to relevant earth science content. The EarthObserver base map is the Global Multi-Resolution Topography digital elevation model (GMRT; http://www.marine-geo.org/portals/gmrt/), also developed at LDEO and updated regularly. It provides land elevations with horizontal resolution as high as 10m for mainland USA and 30m globally, and detailed oceanic depths derived from numerous sources including multibeam echo-soundings data.

  14. Assessing Upper-Level Winds on Day-of-Launch

    NASA Technical Reports Server (NTRS)

    Bauman, William H., III; Wheeler, Mark M.

    2012-01-01

    On the day-or-launch. the 45th Weather Squadron Launch Weather Officers (LWOS) monitor the upper-level winds for their launch customers to include NASA's Launch Services Program (LSP). During launch operations, the payload launch team sometimes asks the LWO if they expect the upper level winds to change during the countdown but the LWOs did not have the capability to quickly retrieve or display the upper-level observations and compare them to the numerical weather prediction model point forecasts. The LWOs requested the Applied Meteorology Unit (AMU) develop a capability in the form of a graphical user interface (GUI) that would allow them to plot upper-level wind speed and direction observations from the Kennedy Space Center Doppler Radar Wind Profilers and Cape Canaveral Air Force Station rawinsondes and then overlay model point forecast profiles on the observation profiles to assess the performance of these models and graphically display them to the launch team. The AMU developed an Excel-based capability for the LWOs to assess the model forecast upper-level winds and compare them to observations. They did so by creating a GUI in Excel that allows the LWOs to first initialize the models by comparing the O-hour model forecasts to the observations and then to display model forecasts in 3-hour intervals from the current time through 12 hours.

  15. Ultrafast carrier thermalization and trapping in silicon-germanium alloy probed by extreme ultraviolet transient absorption spectroscopy

    DOE PAGES

    Zürch, Michael; Chang, Hung-Tzu; Kraus, Peter M.; ...

    2017-06-06

    Semiconductor alloys containing silicon and germanium are of growing importance for compact and highly efficient photonic devices due to their favorable properties for direct integration into silicon platforms and wide tunability of optical parameters. Here, we report the simultaneous direct and energy-resolved probing of ultrafast electron and hole dynamics in a silicon-germanium alloy with the stoichiometry Si 0.25Ge 0.75 by extreme ultraviolet transient absorption spectroscopy. Probing the photoinduced dynamics of charge carriers at the germanium M 4,5-edge (~30 eV) allows the germanium atoms to be used as reporter atoms for carrier dynamics in the alloy. The photoexcitation of electrons acrossmore » the direct and indirect band gap into conduction band (CB) valleys and their subsequent hot carrier relaxation are observed and compared to pure germanium, where the Ge direct (ΔE gap,Ge,direct = 0.8 eV) and Si 0.25Ge 0.75 indirect gaps (ΔE gap,Si0.25Ge0.75,indirect = 0.95 eV) are comparable in energy. In the alloy, comparable carrier lifetimes are observed for the X, L, and Γ valleys in the conduction band. A midgap feature associated with electrons accumulating in trap states near the CB edge following intraband thermalization is observed in the Si 0.25Ge 0.75 alloy. The successful implementation of the reporter atom concept for capturing the dynamics of the electronic bands by site-specific probing in solids opens a route to study carrier dynamics in more complex materials with femtosecond and sub-femtosecond temporal resolution.« less

  16. The Radial Speed - Expansion Speed Relation for Earth-Directed CMEs

    NASA Astrophysics Data System (ADS)

    Makela, P. A.; Gopalswamy, N.; Yashiro, S.

    2013-12-01

    The propagation speed of Earth-directed coronal mass ejections (CMEs) is an essential parameter needed in space weather forecasting. However, the true propagation speed of Earth-directed CMEs cannot be measured accurately from coronagraph images taken from Earth's view. In order to circumvent the inaccuracies of speed measurements due to the projection effects, empirical relations expressing the radial speed (Vrad) of the CME as a function of the CME expansion speed (Vexp) have been suggested. Vexp is defined as the apparent speed the CME is spreading in the coronagraph's field of view. During 2010-2012 STEREO spacecraft provided a side view of Earth-directed CMEs, allowing measurements of true CME speeds and widths. In a case study of the 2011 February 15 CME Gopalswamy et al. (2012) compared three Vrad-Vexp relations (flat cone, full or shallow ice cream cone - Gopalswamy et al., 2009) and found the closest match with the observations for the (full ice cream cone) relation Vrad = 1/2(1 + cot w)Vexp, where w is the half width of the CME. Using the STEREO/SECCHI and SOHO/LASCO observations during this opportune period, we expand this analysis to a larger set of Earth-directed CMEs. We compare the computed CME speed estimates with the measured true speeds and estimate the accuracy of the Vrad-Vexp relations. References: Gopalswamy, N. et al. (2009), The expansion and radial speeds of coronal mass ejections, Cent. Eur. Astrophys. Bull., 33, 115. Gopalswamy, N. et al. (2012), The relationship between the expansion speed and radial speed of CMEs confirmed using quadrature observations of the 2011 February 15 CME, Sun and Geosphere, 7(1), 7.

  17. NoMelt Experiment: High-resolution constraints on Pacific upper mantle fabric inferred from radial and azimuthal anisotropy

    NASA Astrophysics Data System (ADS)

    Russell, J. B.; Gaherty, J. B.; Lin, P. P.; Lizarralde, D.; Collins, J. A.; Hirth, G.; Evans, R. L.

    2017-12-01

    Observations of seismic anisotropy in the ocean basins are important for constraining deformation and melting processes in the upper mantle. The NoMelt OBS array was deployed on relatively pristine, 70 Ma seafloor in the central Pacific with the aim of constraining upper mantle circulation and the evolution of the lithosphere-asthenosphere system. Surface-waves traversing the array provide a unique opportunity to estimate a comprehensive set of anisotropic parameters. Azimuthal variations in Rayleigh-wave velocity over a period band of 15-180 s suggest strong anisotropic fabric both in the lithosphere and deep in the asthenosphere. High-frequency ambient noise (4-10 s) provides constraints on average VSV and VSH as well as azimuthal variations in both VS and VP in the upper ˜10 km of the mantle. Our best fitting models require radial anisotropy in the uppermost mantle with VSH > VSV by 3 - 7% and as much as 2% radial anisotropy in the crust. Additionally, we find a strong azimuthal dependence for Rayleigh- and Love-wave velocities, with Rayleigh 2θ fast direction parallel to the fossil spreading direction (FSD) and Love 2θ and 4θ fast directions shifted 90º and 45º from the FSD, respectively. These are some of the first direct observations of the Love 2θ and 4θ azimuthal signal, which allows us to directly invert for anisotropic terms G, B, and E in the uppermost Pacific lithosphere, for the first time. Together, these observations of radial and azimuthal anisotropy provide a comprehensive picture of oceanic mantle fabric and are consistent with horizontal alignment of olivine with the a-axis parallel to fossil spreading and having an orthorhombic or hexagonal symmetry.

  18. Ultrafast carrier thermalization and trapping in silicon-germanium alloy probed by extreme ultraviolet transient absorption spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zürch, Michael; Chang, Hung-Tzu; Kraus, Peter M.

    Semiconductor alloys containing silicon and germanium are of growing importance for compact and highly efficient photonic devices due to their favorable properties for direct integration into silicon platforms and wide tunability of optical parameters. Here, we report the simultaneous direct and energy-resolved probing of ultrafast electron and hole dynamics in a silicon-germanium alloy with the stoichiometry Si 0.25Ge 0.75 by extreme ultraviolet transient absorption spectroscopy. Probing the photoinduced dynamics of charge carriers at the germanium M 4,5-edge (~30 eV) allows the germanium atoms to be used as reporter atoms for carrier dynamics in the alloy. The photoexcitation of electrons acrossmore » the direct and indirect band gap into conduction band (CB) valleys and their subsequent hot carrier relaxation are observed and compared to pure germanium, where the Ge direct (ΔE gap,Ge,direct = 0.8 eV) and Si 0.25Ge 0.75 indirect gaps (ΔE gap,Si0.25Ge0.75,indirect = 0.95 eV) are comparable in energy. In the alloy, comparable carrier lifetimes are observed for the X, L, and Γ valleys in the conduction band. A midgap feature associated with electrons accumulating in trap states near the CB edge following intraband thermalization is observed in the Si 0.25Ge 0.75 alloy. The successful implementation of the reporter atom concept for capturing the dynamics of the electronic bands by site-specific probing in solids opens a route to study carrier dynamics in more complex materials with femtosecond and sub-femtosecond temporal resolution.« less

  19. Spatial and temporal modulation of joint stiffness during multijoint movement.

    PubMed

    Mah, C D

    2001-02-01

    Joint stiffness measurements during small transient perturbations have suggested that stiffness during movement is different from that observed during posture. These observations are problematic for theories like the classical equilibrium point hypothesis, which suggest that desired trajectories during movement are enforced by joint stiffness. We measured arm impedances during large, slow perturbations to obtain detailed information about the spatial and temporal modulation of stiffness and viscosity during movement. While our measurements of stiffness magnitudes during movement generally agreed with the results of measurements using fast perturbations, they revealed that joint stiffness undergoes stereotyped changes in magnitude and aspect ratio which depend on the direction of movement and show a strong dependence on joint angles. Movement simulations using measured parameters show that the measured modulation of impedance acts as an energy conserving force field to constrain movement. This mechanism allows for a computationally simplified account of the execution of multijoint movement. While our measurements do not rule out a role for afferent feedback in force generation, the observed stereotyped restoring forces can allow a dramatic relaxation of the accuracy requirements for forces generated by other control mechanisms, such as inverse dynamical models.

  20. Time and Frequency Synchronization on the Virac Radio Telescope RT-32

    NASA Astrophysics Data System (ADS)

    Bezrukovs, V.

    2016-04-01

    One of the main research directions of Ventspils International Radio Astronomy Centre (VIRAC) is radio astronomy and astrophysics. The instrumental base for the centre comprised two fully steerable parabolic antennas, RT-16 and RT-32 (i.e. with the mirror diameter of 16 m and 32 m). After long reconstruction, radio telescope RT-32 is currently equipped with the receiving and data acquisition systems that allow observing in a wide frequency range from 327 MHz to 9 GHz. New Antenna Control Unit (ACU) allows stable, fast and precise pointing of antenna. Time and frequency distribution service provide 5, 10 and 100 MHz reference frequency, 1PPS signals and precise time stamps by NTP protocol and in the IRIG-B format by coaxial cable. For the radio astronomical observations, main requirement of spatially Very Long Base Line Interferometric (VLBI) observations for the observatory is precise synchronization of the received and sampled data and linking to the exact time stamps. During October 2015, radio telescope RT-32 performance was tested in several successful VLBI experiments. The obtained results confirm the efficiency of the chosen methods of synchronization and the ability to reproduce them on similar antennas.

  1. Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory

    DOE PAGES

    Abreu, P

    2011-06-17

    The Pierre Auger Collaboration has reported evidence for anisotropy in the distribution of arrival directions of the cosmic rays with energies E > E th = 5.5 x 10 19 eV. These show a correlation with the distribution of nearby extragalactic objects, including an apparent excess around the direction of Centaurus A. If the particles responsible for these excesses at E > E th are heavy nuclei with charge Z, the proton component of the sources should lead to excesses in the same regions at energies E/Z. We here report the lack of anisotropies in these directions at energies abovemore » E th/Z (for illustrative values of Z = 6,13,26). If the anisotropies above E th are due to nuclei with charge Z, and under reasonable assumptions about the acceleration process, these observations imply stringent constraints on the allowed proton fraction at the lower energies.« less

  2. Construction and direct electrochemistry of orientation controlled laccase electrode.

    PubMed

    Li, Ying; Zhang, Jiwei; Huang, Xirong; Wang, Tianhong

    2014-03-28

    A laccase has multiple redox centres. Chemisorption of laccases on a gold electrode through a polypeptide tag introduced at the protein surface provides an isotropic orientation of laccases on the Au surface, which allows the orientation dependent study of the direct electrochemistry of laccase. In this paper, using genetic engineering technology, two forms of recombinant laccase which has Cys-6×His tag at the N or C terminus were generated. Via the Au-S linkage, the recombinant laccase was assembled orientationally on gold electrode. A direct electron transfer and a bioelectrocatalytic activity toward oxygen reduction were observed on the two orientation controlled laccase electrodes, but their electrochemical behaviors were found to be quite different. The orientation of laccase on the gold electrode affects both the electron transfer pathway and the electron transfer efficiency of O2 reduction. The present study is helpful not only to the in-depth understanding of the direct electrochemistry of laccase, but also to the development of laccase-based biofuel cells. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Solutions Network Formulation Report. Integrating Salinity Measurements from Aquarius into the Harmful Algal Blooms Observing System

    NASA Technical Reports Server (NTRS)

    Anderson, Daniel; Lewis, David; Hilbert, Kent

    2007-01-01

    This Candidate Solution suggests the use of Aquarius sea surface salinity measurements to improve the NOAA/NCDDC (National Oceanic and Atmospheric Administration s National Coastal Data Development Center) HABSOS (Harmful Algal Blooms Observing System) DST (decision support tool) by enhancing development and movement forecasts of HAB events as well as potential species identification. In the proposed configuration, recurring salinity measurements from the Aquarius mission would augment HABSOS sea surface temperature and in situ ocean current measurements. Thermohaline circulation observations combined with in situ measurements increase the precision of HAB event movement forecasting. These forecasts allow coastal managers and public health officials to make more accurate and timely warnings to the public and to better direct science teams to event sites for collection and further measurements.

  4. Ex situ investigation of the step bunching on crystal surfaces by atomic force microscopy

    NASA Astrophysics Data System (ADS)

    Krasinski, Mariusz J.

    1997-07-01

    We are describing ex situ observation of step bunching on the surfaces of solution grown potassium dihydrogen phosphate (KDP) and sodium chlorate monocrystals. The measurements have been done with the use of atomic force microscope. The use of this equipment allowed us to see directly the structure of macrosteps. Observation confirmed the existence of step pinning which is one of the proposed mechanisms of step bunching. Despite the very high resolution of AFM it was not possible to determine the nature of pinning point. The monatomic steps on KDP and sodium chlorate crystal surfaces are mainly one unit cell high what seems to be the result of the steps pairing. The origin of observed step pattern is discussed in frames of existing theories.

  5. Modelling Gravitational Radiation from Binary Black Holes

    NASA Technical Reports Server (NTRS)

    Centrella, Joan

    2006-01-01

    The final merger and coalescence of binary black holes is a key source of strong gravitational waves for the LISA mission. Observing these systems will allow us to probe the formation of cosmic structure to high redshifts and test general relativity directly in the strong-field, dynamical regime. Recently, major breakthroughs have been made in modeling black hole mergers using numerical relativity. This talk will survey these exciting developments, focusing on the gravitational waveforms and the recoil kicks produced from non-equal mass mergers.

  6. Analytical and Radio-Histo-Chemical Experiments of Plants and Tissue Culture Cells Treated with Lunar and Terrestrial Materials

    NASA Technical Reports Server (NTRS)

    Halliwell, R. S.

    1973-01-01

    The nature and mechanisms of the apparent simulation of growth originally observed in plants growing in contact with lunar soil during the Apollo project quarantine are examined. Preliminary experiments employing neutron activated lunar soil indicate uptake of a few elements by plants. It was found that while the preliminary neutron activation technique allowed demonstration of uptake of minerals it presented numerous disadvantages for use in critical experiments directed at elucidating possible mechanisms of stimulation.

  7. Developing and Validating Personas in e-Commerce: A Heuristic Approach

    NASA Astrophysics Data System (ADS)

    Thoma, Volker; Williams, Bryn

    A multi-method persona development process in a large e-commerce business is described. Personas are fictional representations of customers that describe typical user attributes to facilitate a user-centered approach in interaction design. In the current project persona attributes were derived from various data sources, such as stakeholder interviews, user tests and interviews, data mining, customer surveys, and ethnographic (direct observation, diary studies) research. The heuristic approach of using these data sources conjointly allowed for an early validation of relevant persona dimensions.

  8. Gravitational-Wave Astronomy

    NASA Technical Reports Server (NTRS)

    Kelly, Bernard J.

    2010-01-01

    Einstein's General Theory of Relativity is our best classical description of gravity, and informs modern astronomy and astrophysics at all scales: stellar, galactic, and cosmological. Among its surprising predictions is the existence of gravitational waves -- ripples in space-time that carry energy and momentum away from strongly interacting gravitating sources. In my talk, I will give an overview of the properties of this radiation, recent breakthroughs in computational physics allowing us to calculate the waveforms from galactic mergers, and the prospect of direct observation with interferometric detectors such as LIGO and LISA.

  9. Light Augmentation Device: A New Surgical Tool for Improved Laparoscopic Visibility and Transillumination: Proof-of-Concept Study.

    PubMed

    Asti, Emanuele; Nebbia, Fabio; Sironi, Andrea; Bottino, Vincenzo; Bonitta, Gianluca; Bonavina, Luigi

    2016-12-01

    The light augmentation device (LAD ® ) is a new disposable tool designed to improve observation by transillumination in laparoscopic surgery. It can be introduced into the abdomen through an 11-12 mm port as a supplementary light source. The miniaturized design allows the surgeon to pick up the device with an endograsper and to place it under direct vision where needed. This proof-of-concept study demonstrated safety and efficacy of the device in the animal model.

  10. Binder model system to be used for determination of prepolymer functionality

    NASA Technical Reports Server (NTRS)

    Martinelli, F. J.; Hodgkin, J. H.

    1971-01-01

    Development of a method for determining the functionality distribution of prepolymers used for rocket binders is discussed. Research has been concerned with accurately determining the gel point of a model polyester system containing a single trifunctional crosslinker, and the application of these methods to more complicated model systems containing a second trifunctional crosslinker, monofunctional ingredients, or a higher functionality crosslinker. Correlations of observed with theoretical gel points for these systems would allow the methods to be applied directly to prepolymers.

  11. Estimation of coupling between time-delay systems from time series

    NASA Astrophysics Data System (ADS)

    Prokhorov, M. D.; Ponomarenko, V. I.

    2005-07-01

    We propose a method for estimation of coupling between the systems governed by scalar time-delay differential equations of the Mackey-Glass type from the observed time series data. The method allows one to detect the presence of certain types of linear coupling between two time-delay systems, to define the type, strength, and direction of coupling, and to recover the model equations of coupled time-delay systems from chaotic time series corrupted by noise. We verify our method using both numerical and experimental data.

  12. Discord as a quantum resource for bi-partite communication

    NASA Astrophysics Data System (ADS)

    Chrzanowski, Helen M.; Gu, Mile; Assad, Syed M.; Symul, Thomas; Modi, Kavan; Ralph, Timothy C.; Vedral, Vlatko; Lam, Ping Koy

    2014-12-01

    Coherent interactions that generate negligible entanglement can still exhibit unique quantum behaviour. This observation has motivated a search beyond entanglement for a complete description of all quantum correlations. Quantum discord is a promising candidate. Here, we experimentally demonstrate that under certain measurement constraints, discord between bipartite systems can be consumed to encode information that can only be accessed by coherent quantum interactions. The inability to access this information by any other means allows us to use discord to directly quantify this `quantum advantage'.

  13. A Review of Fluorescent Proteins for Use in Yeast.

    PubMed

    Bialecka-Fornal, Maja; Makushok, Tatyana; Rafelski, Susanne M

    2016-01-01

    The field of fluorescent proteins (FPs) is constantly developing. The use of FPs changed the field of life sciences completely, starting a new era of direct observation and quantification of cellular processes. The broad spectrum of FPs (see Fig. 1) with a wide range of characteristics allows their use in many different experiments. This review discusses the use of FPs for imaging in budding yeast (Saccharomyces cerevisiae) and fission yeast Schizosaccharomyces pombe). The information included in this review is relevant for both species unless stated otherwise.

  14. Comparison of coherently coupled multi-cavity and quantum dot embedded single cavity systems.

    PubMed

    Kocaman, Serdar; Sayan, Gönül Turhan

    2016-12-12

    Temporal group delays originating from the optical analogue to electromagnetically induced transparency (EIT) are compared in two systems. Similar transmission characteristics are observed between a coherently coupled high-Q multi-cavity array and a single quantum dot (QD) embedded cavity in the weak coupling regime. However, theoretically generated group delay values for the multi-cavity case are around two times higher. Both configurations allow direct scalability for chip-scale optical pulse trapping and coupled-cavity quantum electrodynamics (QED).

  15. Thomson-backscattered x rays from laser-accelerated electrons.

    PubMed

    Schwoerer, H; Liesfeld, B; Schlenvoigt, H-P; Amthor, K-U; Sauerbrey, R

    2006-01-13

    We present the first observation of Thomson-backscattered light from laser-accelerated electrons. In a compact, all-optical setup, the "photon collider," a high-intensity laser pulse is focused into a pulsed He gas jet and accelerates electrons to relativistic energies. A counterpropagating laser probe pulse is scattered from these high-energy electrons, and the backscattered x-ray photons are spectrally analyzed. This experiment demonstrates a novel source of directed ultrashort x-ray pulses and additionally allows for time-resolved spectroscopy of the laser acceleration of electrons.

  16. Observing and preventing rubidium runaway in a direct-infusion xenon-spin hyperpolarizer optimized for high-resolution hyper-CEST (chemical exchange saturation transfer using hyperpolarized nuclei) NMR.

    PubMed

    Witte, C; Kunth, M; Rossella, F; Schröder, L

    2014-02-28

    Xenon is well known to undergo host-guest interactions with proteins and synthetic molecules. As xenon can also be hyperpolarized by spin exchange optical pumping, allowing the investigation of highly dilute systems, it makes an ideal nuclear magnetic resonance probe for such host molecules. The utility of xenon as a probe can be further improved using Chemical Exchange Saturation Transfer using hyperpolarized nuclei (Hyper-CEST), but for highly accurate experiments requires a polarizer and xenon infusion system optimized for such measurements. We present the design of a hyperpolarizer and xenon infusion system specifically designed to meet the requirements of Hyper-CEST measurements. One key element of this design is preventing rubidium runaway, a chain reaction induced by laser heating that prevents efficient utilization of high photon densities. Using thermocouples positioned along the pumping cell we identify the sources of heating and conditions for rubidium runaway to occur. We then demonstrate the effectiveness of actively cooling the optical cell to prevent rubidium runaway in a compact setup. This results in a 2-3-fold higher polarization than without cooling, allowing us to achieve a polarization of 25% at continuous flow rates of 9 ml/min of (129)Xe. The simplicity of this design also allows it to be retrofitted to many existing polarizers. Combined with a direction infusion system that reduces shot-to-shot noise down to 0.56% we have captured Hyper-CEST spectra in unprecedented detail, allowing us to completely resolve peaks separated by just 1.62 ppm. Due to its high polarization and excellent stability, our design allows the comparison of underlying theories of host-guest systems with experiment at low concentrations, something extremely difficult with previous polarizers.

  17. 3-D sprag ratcheting tool

    NASA Technical Reports Server (NTRS)

    Wade, Michael O. (Inventor); Poland, Jr., James W. (Inventor)

    2003-01-01

    A ratcheting device comprising a driver head assembly which includes at least two 3-D sprag elements positioned within a first groove within the driver head assembly such that at least one of the 3-D sprag elements may lockingly engage the driver head assembly and a mating hub assembly to allow for rotation of the hub assembly in one direction with respect to the driver head assembly. This arrangement allows the ratcheting tool to impart torque in either the clockwise or counterclockwise direction without having to first rotate the ratcheting tool in the direction opposite the direction in which the torque is applied. This arrangement also allows the ratcheting tool to impart torque in either the clockwise or counterclockwise direction while in the neutral position.

  18. Origins and Scaling of Hot-Electron Preheat in Ignition-Scale Direct-Drive Inertial Confinement Fusion Experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenberg, M. J.; Solodov, A. A.; Myatt, J. F.

    Planar laser-plasma interaction (LPI) experiments at the National Ignition Facility (NIF) have allowed access for the rst time to regimes of electron density scale length (~500 to 700 μm), electron temperature (~3 to 5 keV), and laser intensity (6 to 16 x 10 14 W/cm 2) that are relevant to direct-drive inertial confinement fusion ignition. Unlike in shorter-scale-length plasmas on OMEGA, scattered-light data on the NIF show that the near-quarter-critical LPI physics is dominated by stimulated Raman scattering (SRS) rather than by two-plasmon decay (TPD). This difference in regime is explained based on absolute SRS and TPD threshold considerations. SRSmore » sidescatter tangential to density contours and other SRS mechanisms are observed. The fraction of laser energy converted to hot electrons is ~0.7% to 2.9%, consistent with observed levels of SRS. The intensity threshold for hot-electron production is assessed, and the use of a Si ablator slightly increases this threshold from ~4 x 10 14 to ~6 x 10 14 W/cm 2. These results have significant implications for mitigation of LPI hot-electron preheat in direct-drive ignition designs.« less

  19. Incorporating variability in honey bee waggle dance decoding improves the mapping of communicated resource locations.

    PubMed

    Schürch, Roger; Couvillon, Margaret J; Burns, Dominic D R; Tasman, Kiah; Waxman, David; Ratnieks, Francis L W

    2013-12-01

    Honey bees communicate to nestmates locations of resources, including food, water, tree resin and nest sites, by making waggle dances. Dances are composed of repeated waggle runs, which encode the distance and direction vector from the hive or swarm to the resource. Distance is encoded in the duration of the waggle run, and direction is encoded in the angle of the dancer's body relative to vertical. Glass-walled observation hives enable researchers to observe or video, and decode waggle runs. However, variation in these signals makes it impossible to determine exact locations advertised. We present a Bayesian duration to distance calibration curve using Markov Chain Monte Carlo simulations that allows us to quantify how accurately distance to a food resource can be predicted from waggle run durations within a single dance. An angular calibration shows that angular precision does not change over distance, resulting in spatial scatter proportional to distance. We demonstrate how to combine distance and direction to produce a spatial probability distribution of the resource location advertised by the dance. Finally, we show how to map honey bee foraging and discuss how our approach can be integrated with Geographic Information Systems to better understand honey bee foraging ecology.

  20. Origins and Scaling of Hot-Electron Preheat in Ignition-Scale Direct-Drive Inertial Confinement Fusion Experiments

    DOE PAGES

    Rosenberg, M. J.; Solodov, A. A.; Myatt, J. F.; ...

    2018-01-29

    Planar laser-plasma interaction (LPI) experiments at the National Ignition Facility (NIF) have allowed access for the rst time to regimes of electron density scale length (~500 to 700 μm), electron temperature (~3 to 5 keV), and laser intensity (6 to 16 x 10 14 W/cm 2) that are relevant to direct-drive inertial confinement fusion ignition. Unlike in shorter-scale-length plasmas on OMEGA, scattered-light data on the NIF show that the near-quarter-critical LPI physics is dominated by stimulated Raman scattering (SRS) rather than by two-plasmon decay (TPD). This difference in regime is explained based on absolute SRS and TPD threshold considerations. SRSmore » sidescatter tangential to density contours and other SRS mechanisms are observed. The fraction of laser energy converted to hot electrons is ~0.7% to 2.9%, consistent with observed levels of SRS. The intensity threshold for hot-electron production is assessed, and the use of a Si ablator slightly increases this threshold from ~4 x 10 14 to ~6 x 10 14 W/cm 2. These results have significant implications for mitigation of LPI hot-electron preheat in direct-drive ignition designs.« less

  1. Direct Observation of Virtual Electrode Formation Through a Novel Electrolyte-to-Electrode Transition

    NASA Astrophysics Data System (ADS)

    Siegel, David; El Gabaly, Farid; Bartelt, Norman; McCarty, Kevin

    2014-03-01

    Novel electrochemical solutions to problems in energy storage and transportation can drive renewable energy to become an economically viable alternative to fossil fuels. In many electrochemical systems, the behavior of a device can be fundamentally limited by the surface area of a triple phase boundary, the boundary region where a gas-phase species, electrode, and electrolyte coincide. When the electrode is an ionic insulator the triple phase boundary is typically a one-dimensional boundary with nanometer-scale thickness: ions cannot transport through the electrode, while electrons cannot be transported through the electrolyte. Here we present direct experimental measurements of a novel electrolyte-to-electrode transition with photoemission electron microscopy, and observe that the surface of an ionically conductive, electronically insulative solid oxide electrolyte undergoes a transition into a mixed electron-ion conductor in the vicinity of a metal electrode. Our direct experimental measurements allow us to characterize this system and address the mechanisms of ionic reactions and transport through comparisons with theoretical modeling to provide us with a physical picture of the processes involved. Our results provide insight into one of the mechanisms of ion transport in an electrochemical cell that may be generalizable to other systems.

  2. Origins and Scaling of Hot-Electron Preheat in Ignition-Scale Direct-Drive Inertial Confinement Fusion Experiments

    NASA Astrophysics Data System (ADS)

    Rosenberg, M. J.; Solodov, A. A.; Myatt, J. F.; Seka, W.; Michel, P.; Hohenberger, M.; Short, R. W.; Epstein, R.; Regan, S. P.; Campbell, E. M.; Chapman, T.; Goyon, C.; Ralph, J. E.; Barrios, M. A.; Moody, J. D.; Bates, J. W.

    2018-01-01

    Planar laser-plasma interaction (LPI) experiments at the National Ignition Facility (NIF) have allowed access for the first time to regimes of electron density scale length (˜500 to 700 μ m ), electron temperature (˜3 to 5 keV), and laser intensity (6 to 16 ×1014 W /cm2 ) that are relevant to direct-drive inertial confinement fusion ignition. Unlike in shorter-scale-length plasmas on OMEGA, scattered-light data on the NIF show that the near-quarter-critical LPI physics is dominated by stimulated Raman scattering (SRS) rather than by two-plasmon decay (TPD). This difference in regime is explained based on absolute SRS and TPD threshold considerations. SRS sidescatter tangential to density contours and other SRS mechanisms are observed. The fraction of laser energy converted to hot electrons is ˜0.7 % to 2.9%, consistent with observed levels of SRS. The intensity threshold for hot-electron production is assessed, and the use of a Si ablator slightly increases this threshold from ˜4×10 14 to ˜6 ×1014 W /cm2 . These results have significant implications for mitigation of LPI hot-electron preheat in direct-drive ignition designs.

  3. Self-interacting inelastic dark matter: a viable solution to the small scale structure problems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blennow, Mattias; Clementz, Stefan; Herrero-Garcia, Juan, E-mail: emb@kth.se, E-mail: scl@kth.se, E-mail: juan.herrero-garcia@adelaide.edu.au

    2017-03-01

    Self-interacting dark matter has been proposed as a solution to the small-scale structure problems, such as the observed flat cores in dwarf and low surface brightness galaxies. If scattering takes place through light mediators, the scattering cross section relevant to solve these problems may fall into the non-perturbative regime leading to a non-trivial velocity dependence, which allows compatibility with limits stemming from cluster-size objects. However, these models are strongly constrained by different observations, in particular from the requirements that the decay of the light mediator is sufficiently rapid (before Big Bang Nucleosynthesis) and from direct detection. A natural solution tomore » reconcile both requirements are inelastic endothermic interactions, such that scatterings in direct detection experiments are suppressed or even kinematically forbidden if the mass splitting between the two-states is sufficiently large. Using an exact solution when numerically solving the Schrödinger equation, we study such scenarios and find regions in the parameter space of dark matter and mediator masses, and the mass splitting of the states, where the small scale structure problems can be solved, the dark matter has the correct relic abundance and direct detection limits can be evaded.« less

  4. Direct Visualization of Exciton Reequilibration in the LH1 and LH2 Complexes of Rhodobacter sphaeroides by Multipulse Spectroscopy

    PubMed Central

    Cohen Stuart, Thomas A.; Vengris, Mikas; Novoderezhkin, Vladimir I.; Cogdell, Richard J.; Hunter, C. Neil; van Grondelle, Rienk

    2011-01-01

    The dynamics of the excited states of the light-harvesting complexes LH1 and LH2 of Rhodobacter sphaeroides are governed, mainly, by the excitonic nature of these ring-systems. In a pump-dump-probe experiment, the first pulse promotes LH1 or LH2 to its excited state and the second pulse dumps a portion of the excited state. By selective dumping, we can disentangle the dynamics normally hidden in the excited-state manifold. We find that by using this multiple-excitation technique we can visualize a 400-fs reequilibration reflecting relaxation between the two lowest exciton states that cannot be directly explored by conventional pump-probe. An oscillatory feature is observed within the exciton reequilibration, which is attributed to a coherent motion of a vibrational wavepacket with a period of ∼150 fs. Our disordered exciton model allows a quantitative interpretation of the observed reequilibration processes occurring in these antennas. PMID:21539791

  5. Direct visualization of exciton reequilibration in the LH1 and LH2 complexes of Rhodobacter sphaeroides by multipulse spectroscopy.

    PubMed

    Cohen Stuart, Thomas A; Vengris, Mikas; Novoderezhkin, Vladimir I; Cogdell, Richard J; Hunter, C Neil; van Grondelle, Rienk

    2011-05-04

    The dynamics of the excited states of the light-harvesting complexes LH1 and LH2 of Rhodobacter sphaeroides are governed, mainly, by the excitonic nature of these ring-systems. In a pump-dump-probe experiment, the first pulse promotes LH1 or LH2 to its excited state and the second pulse dumps a portion of the excited state. By selective dumping, we can disentangle the dynamics normally hidden in the excited-state manifold. We find that by using this multiple-excitation technique we can visualize a 400-fs reequilibration reflecting relaxation between the two lowest exciton states that cannot be directly explored by conventional pump-probe. An oscillatory feature is observed within the exciton reequilibration, which is attributed to a coherent motion of a vibrational wavepacket with a period of ∼150 fs. Our disordered exciton model allows a quantitative interpretation of the observed reequilibration processes occurring in these antennas. Copyright © 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Trang Nghiêm, T. T.; Chapuis, Pierre-Olivier

    The wave property of phonons is employed to explore the thermal transport across a finite periodic array of nano-scatterers such as circular and triangular holes. As thermal phonons are generated in all directions, we study their transmission through a single array for both normal and oblique incidences, using a linear dispersionless time-dependent acoustic frame in a two-dimensional system. Roughness effects can be directly considered within the computations without relying on approximate analytical formulae. Analysis by spatio-temporal Fourier transform allows us to observe the diffraction effects and the conversion of polarization. Frequency-dependent energy transmission coefficients are computed for symmetric and asymmetricmore » objects that are both subject to reciprocity. We demonstrate that the phononic array acts as an efficient thermal barrier by applying the theory of thermal boundary (Kapitza) resistances to arrays of smooth scattering holes in silicon for an exemplifying periodicity of 10 nm in the 5–100 K temperature range. It is observed that the associated thermal conductance has the same temperature dependence as that without phononic filtering.« less

  7. Utilizing X-ray gas velocity measurements as a new probe of AGN feedback in giant elliptical galaxies

    NASA Astrophysics Data System (ADS)

    Ogorzalek, Anna; Zhuravleva, Irina; Allen, Steven W.; Pinto, Ciro; Werner, Norbert; Mantz, Adam; Canning, Rebecca; Fabian, Andrew C.; Kaastra, Jelle S.; de Plaa, Jelle

    2017-08-01

    Velocity structure of hot atmospheres of massive early-type galaxies remains a key open question in our understanding of galaxy formation and mechanical AGN feedback. Using a combination of resonant scattering and direct line broadening techniques applied to deep XMM-Newton Reflection Grating Spectrometer observations has allowed us to for the first time measure turbulent velocities in the cores of 13 nearby giant early-type galaxies, opening up the possibility of population studies of hot gas motions in such objects. Our method has also been successfully applied to the Hitomi Perseus observation, serving as an independent velocity probe of the cluster ICM. In this talk I will introduce our measurements and discuss their implications on the physics of kinetic AGN feedback. I will also outline future directions, emphasizing the role of resonant scattering in studying gas dynamics of cooler (~1 keV) systems, such as giant galaxies, as well as its importance for the correct interpretation of high resolution X-ray spectra from XARM and Athena.

  8. Description and preliminary results of a 100 square meter rain gauge

    NASA Astrophysics Data System (ADS)

    Grimaldi, Salvatore; Petroselli, Andrea; Baldini, Luca; Gorgucci, Eugenio

    2018-01-01

    Rainfall is one of the most crucial processes in hydrology, and the direct and indirect rainfall measurement methods are constantly being updated and improved. The standard instrument used to measure rainfall rate and accumulation is the rain gauge, which provides direct observations. Though the small dimension of the orifice allows rain gauges to be installed anywhere, it also causes errors due to the splash and wind effects. To investigate the role of the orifice dimension, this study, for the first time, introduces and demonstrates an apparatus for observing rainfall called a giant-rain gauge that is characterised by a collecting surface of 100 m2. To discuss the new instrument and its technical details, a preliminary analysis of 26 rainfall events is provided. The results suggest that there are significant differences between the standard and proposed rain gauges. Specifically, major discrepancies are evident for low time aggregation scale (5, 10, and 15 min) and for high rainfall intensity values.

  9. Column-by-column observation of dislocation motion in CdTe: Dynamic scanning transmission electron microscopy

    NASA Astrophysics Data System (ADS)

    Li, Chen; Zhang, Yu-Yang; Pennycook, Timothy J.; Wu, Yelong; Lupini, Andrew R.; Paudel, Naba; Pantelides, Sokrates T.; Yan, Yanfa; Pennycook, Stephen J.

    2016-10-01

    The dynamics of partial dislocations in CdTe have been observed at the atomic scale using aberration-corrected scanning transmission electron microscopy (STEM), allowing the mobility of different dislocations to be directly compared: Cd-core Shockley partial dislocations are more mobile than Te-core partials, and dislocation cores with unpaired columns have higher mobility than those without unpaired columns. The dynamic imaging also provides insight into the process by which the dislocations glide. Dislocations with dangling bonds on unpaired columns are found to be more mobile because the dangling bonds mediate the bond exchanges required for the dislocations to move. Furthermore, a screw dislocation has been resolved to dissociate into a Shockley partial-dislocation pair along two different directions, revealing a way for the screw dislocation to glide in the material. The results show that dynamic STEM imaging has the potential to uncover the details of dislocation motion not easily accessible by other means.

  10. Optical Diode Effect at Spin-Wave Excitations of the Room-Temperature Multiferroic BiFeO_{3}.

    PubMed

    Kézsmárki, I; Nagel, U; Bordács, S; Fishman, R S; Lee, J H; Yi, Hee Taek; Cheong, S-W; Rõõm, T

    2015-09-18

    Multiferroics permit the magnetic control of the electric polarization and the electric control of the magnetization. These static magnetoelectric (ME) effects are of enormous interest: The ability to read and write a magnetic state current-free by an electric voltage would provide a huge technological advantage. Dynamic or optical ME effects are equally interesting, because they give rise to unidirectional light propagation as recently observed in low-temperature multiferroics. This phenomenon, if realized at room temperature, would allow the development of optical diodes which transmit unpolarized light in one, but not in the opposite, direction. Here, we report strong unidirectional transmission in the room-temperature multiferroic BiFeO_{3} over the gigahertz-terahertz frequency range. The supporting theory attributes the observed unidirectional transmission to the spin-current-driven dynamic ME effect. These findings are an important step toward the realization of optical diodes, supplemented by the ability to switch the transmission direction with a magnetic or electric field.

  11. Caregiver preference for reinforcement-based interventions for problem behavior maintained by positive reinforcement.

    PubMed

    Gabor, Anne M; Fritz, Jennifer N; Roath, Christopher T; Rothe, Brittany R; Gourley, Denise A

    2016-06-01

    Social validity of behavioral interventions typically is assessed with indirect methods or by determining preferences of the individuals who receive treatment, and direct observation of caregiver preference rarely is described. In this study, preferences of 5 caregivers were determined via a concurrent-chains procedure. Caregivers were neurotypical, and children had been diagnosed with developmental disabilities and engaged in problem behavior maintained by positive reinforcement. Caregivers were taught to implement noncontingent reinforcement (NCR), differential reinforcement of alternative behavior (DRA), and differential reinforcement of other behavior (DRO), and the caregivers selected interventions to implement during sessions with the child after they had demonstrated proficiency in implementing the interventions. Three caregivers preferred DRA, 1 caregiver preferred differential reinforcement procedures, and 1 caregiver did not exhibit a preference. Direct observation of implementation in concurrent-chains procedures may allow the identification of interventions that are implemented with sufficient integrity and preferred by caregivers. © 2016 Society for the Experimental Analysis of Behavior.

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chianese, Marco; Merle, Alexander, E-mail: chianese@na.infn.it, E-mail: amerle@mpp.mpg.de

    The high energy events observed at the IceCube Neutrino Observatory have triggered many investigations interpreting the highly energetic neutrinos detected as decay products of heavy unstable Dark Matter particles. However, while very detailed treatments of the IceCube phenomenology exist, only a few references focus on the (non-trivial) Dark Matter production part—and all of those rely on relatively complicated new models which are not always testable directly. We instead investigate two of the most minimal scenarios possible, where the operator responsible for the IceCube events is directly involved in Dark Matter production. We show that the simplest (four-dimensional) operator is notmore » powerful enough to accommodate all constraints. A more non-minimal setting (at mass dimension six), however, can do both fitting all the data and also allowing for a comparatively small parameter space only, parts of which can be in reach of future observations. We conclude that minimalistic approaches can be enough to explain all data required, while complicated new physics seems not to be required by IceCube.« less

  13. Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

    PubMed Central

    Niikura, Yohei; Kitagawa, Katsumi

    2016-01-01

    "Centromeres" and "kinetochores" refer to the site where chromosomes associate with the spindle during cell division. Direct visualization of centromere-kinetochore proteins during the cell cycle remains a fundamental tool in investigating the mechanism(s) of these proteins. Advanced imaging methods in fluorescence microscopy provide remarkable resolution of centromere-kinetochore components and allow direct observation of specific molecular components of the centromeres and kinetochores. In addition, methods of indirect immunofluorescent (IIF) staining using specific antibodies are crucial to these observations. However, despite numerous reports about IIF protocols, few discussed in detail problems of specific centromere-kinetochore proteins.1-4 Here we report optimized protocols to stain endogenous centromere-kinetochore proteins in human cells by using paraformaldehyde fixation and IIF staining. Furthermore, we report protocols to detect Flag-tagged exogenous CENP-A proteins in human cells subjected to acetone or methanol fixation. These methods are useful in detecting and quantifying endogenous centromere-kinetochore proteins and Flag-tagged CENP-A proteins, including those in human cells. PMID:26967065

  14. Compaction trends of full stiffness tensor and fluid permeability in artificial shales

    NASA Astrophysics Data System (ADS)

    Beloborodov, Roman; Pervukhina, Marina; Lebedev, Maxim

    2018-03-01

    We present a methodology and describe a set-up that allows simultaneous acquisition of all five elastic coefficients of a transversely isotropic (TI) medium and its permeability in the direction parallel to the symmetry axis during mechanical compaction experiments. We apply the approach to synthetic shale samples and investigate the role of composition and applied stress on their elastic and transport properties. Compaction trends for the five elastic coefficients that fully characterize TI anisotropy of artificial shales are obtained for a porosity range from 40 per cent to 15 per cent. A linear increase of elastic coefficients with decreasing porosity is observed. The permeability acquired with the pressure-oscillation technique exhibits exponential decrease with decreasing porosity. Strong correlations are observed between an axial fluid permeability and seismic attributes, namely, VP/VS ratio and acoustic impedance, measured in the same direction. These correlations might be used to derive permeability of shales from seismic data given that their mineralogical composition is known.

  15. Oxidative Degradation of Nadic-End-Capped Polyimides. 2; Evidence for Reactions Occurring at High Temperatures

    NASA Technical Reports Server (NTRS)

    Meador, Mary Ann B.; Johnston, J. Christopher; Cavano, Paul J.; Frimer, Aryeh A.

    1997-01-01

    The oxidative degradation of PMR (for polymerization of monomeric reactants) polyimides at elevated temperatures was followed by cross-polarized magic angle spinning (Cp-MAS) NMR. C-13 labeling of selected sites in the polymers allowed for direct observation of the transformations arising from oxidation processes. As opposed to model compound studies, the reactions were followed directly in the polymer. The labeling experiments confirm the previously reported oxidation of the methylene carbon to ketone in the methylenedianiline portion of the polymer chain. They also show the formation of two other oxidized species, acid and ester, from this same carbon. In addition, the technique provides the first evidence of the kind of degradation reactions that are occurring in the nadic end caps. Several PMR formulations containing moieties determined to be present after oxidation, as suggested by the labeling study, were synthesized. Weight loss, FTIR, and natural abundance NMR of these derivatives were followed during aging. In this way, weight loss could be related to the observed transformations.

  16. Latent heat contribution to the direct magnetocaloric effect in Ni-Mn-Ga shape memory alloys with coupled martensitic and magnetic transformations

    NASA Astrophysics Data System (ADS)

    Caballero-Flores, R.; Sánchez-Alarcos, V.; Recarte, V.; Pérez-Landazábal, J. I.; Gómez-Polo, C.

    2016-05-01

    We report the direct magnetocaloric response of materials that present a second-order phase transition in the temperature range where a first-order structural transition also occurs. In particular, the influence of the latent heat on the field-induced adiabatic temperature change has been analyzed in a Ni-Mn-Ga alloy with coupled martensitic and magnetic transformations. It is found that discrepancies around 20% arise depending on whether the latent heat is taken into account or not. From the observed results, a general expression for the indirect determination of the adiabatic temperature change, that takes into account the contributions of both the martensitic and magnetic transformations, is proposed and experimentally confirmed. The observed key role of the latent heat allows us to understand why materials with first-order transformations do not present adiabatic temperature changes as higher as those which would correspond to materials undergoing second-order transformations with similar isothermal entropy change.

  17. LOFAR facet callibration

    DOE PAGES

    Weeren, R. J. van; Williams, W. L.; Hardcastle, M. J.; ...

    2016-03-07

    LOFAR, the Low-Frequency Array, is a powerful new radio telescope operating between 10 and 240 MHz. LOFAR allows detailed sensitive high-resolution studies of the low-frequency radio sky. At the same time LOFAR also provides excellent short baseline coverage to map di use extended emission. However, producing high-quality deep images is challenging due to the presence of direction dependent calibration errors, caused by imperfect knowledge of the station beam shapes and the ionosphere. Furthermore, the large data volume and presence of station clock errors present additional di culties. In this paper we present a new calibration scheme, which we name facetmore » calibration, to obtain deep high-resolution LOFAR High Band Antenna images using the Dutch part of the array. This scheme solves and corrects the direction dependent errors in a number of facets that cover the observed eld of view. Facet calibration provides close to thermal noise limited images for a typical 8 hr observing run at ~5'' resolution, meeting the speci cations of the LOFAR Tier-1 northern survey.« less

  18. Chapter 10.3: Reliability and Durability of PV Modules

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kurtz, Sarah

    2017-01-07

    Each year the world invests tens of billions of dollars or euros in PV systems with the expectation that these systems will last approximately 25 years. Although the disciplines of reliability, quality, and service life prediction have been well established for numerous products, a full understanding of these is currently challenging for PV modules because the desired service lifetimes are decades, preventing direct verification of lifetime predictions. A number of excellent reviews can be found in the literature summarizing the types of failures that are commonly observed for PV modules. This chapter discusses key failure/degradation mechanisms selected to highlight howmore » the kinetics of failure rates can and cannot be confidently predicted. For EVA-encapsulated modules, corrosion is observed to follow delamination, which then allows water droplets to directly contact the metallization. Extended test protocols such as Qualification Plus were created to address the known problems while standards groups update standard tests through the consensus process.« less

  19. Modeling the Performance of Direct-Detection Doppler Lidar Systems in Real Atmospheres

    NASA Technical Reports Server (NTRS)

    McGill, Matthew J.; Hart, William D.; McKay, Jack A.; Spinhirne, James D.

    1999-01-01

    Previous modeling of the performance of spaceborne direct-detection Doppler lidar systems has assumed extremely idealized atmospheric models. Here we develop a technique for modeling the performance of these systems in a more realistic atmosphere, based on actual airborne lidar observations. The resulting atmospheric model contains cloud and aerosol variability that is absent in other simulations of spaceborne Doppler lidar instruments. To produce a realistic simulation of daytime performance, we include solar radiance values that are based on actual measurements and are allowed to vary as the viewing scene changes. Simulations are performed for two types of direct-detection Doppler lidar systems: the double-edge and the multi-channel techniques. Both systems were optimized to measure winds from Rayleigh backscatter at 355 nm. Simulations show that the measurement uncertainty during daytime is degraded by only about 10-20% compared to nighttime performance, provided a proper solar filter is included in the instrument design.

  20. Direct evidence of hybodont shark predation on Late Jurassic ammonites

    NASA Astrophysics Data System (ADS)

    Vullo, Romain

    2011-06-01

    Sharks are known to have been ammonoid predators, as indicated by analysis of bite marks or coprolite contents. However, body fossil associations attesting to this predator-prey relationship have never been described so far. Here, I report a unique finding from the Late Jurassic of western France: a complete specimen of the Kimmeridgian ammonite Orthaspidoceras bearing one tooth of the hybodont shark Planohybodus. Some possible tooth puncture marks are also observed. This is the first direct evidence of such a trophic link between these two major Mesozoic groups, allowing an accurate identification of both organisms. Although Planohybodus displays a tearing-type dentition generally assumed to have been especially adapted for large unshelled prey, our discovery clearly shows that this shark was also able to attack robust ammonites such as aspidoceratids. The direct evidence presented here provides new insights into the Mesozoic marine ecosystem food webs.

  1. HIGH DIMENSIONAL COVARIANCE MATRIX ESTIMATION IN APPROXIMATE FACTOR MODELS

    PubMed Central

    Fan, Jianqing; Liao, Yuan; Mincheva, Martina

    2012-01-01

    The variance covariance matrix plays a central role in the inferential theories of high dimensional factor models in finance and economics. Popular regularization methods of directly exploiting sparsity are not directly applicable to many financial problems. Classical methods of estimating the covariance matrices are based on the strict factor models, assuming independent idiosyncratic components. This assumption, however, is restrictive in practical applications. By assuming sparse error covariance matrix, we allow the presence of the cross-sectional correlation even after taking out common factors, and it enables us to combine the merits of both methods. We estimate the sparse covariance using the adaptive thresholding technique as in Cai and Liu (2011), taking into account the fact that direct observations of the idiosyncratic components are unavailable. The impact of high dimensionality on the covariance matrix estimation based on the factor structure is then studied. PMID:22661790

  2. Modeling the performance of direct-detection Doppler lidar systems including cloud and solar background variability.

    PubMed

    McGill, M J; Hart, W D; McKay, J A; Spinhirne, J D

    1999-10-20

    Previous modeling of the performance of spaceborne direct-detection Doppler lidar systems assumed extremely idealized atmospheric models. Here we develop a technique for modeling the performance of these systems in a more realistic atmosphere, based on actual airborne lidar observations. The resulting atmospheric model contains cloud and aerosol variability that is absent in other simulations of spaceborne Doppler lidar instruments. To produce a realistic simulation of daytime performance, we include solar radiance values that are based on actual measurements and are allowed to vary as the viewing scene changes. Simulations are performed for two types of direct-detection Doppler lidar system: the double-edge and the multichannel techniques. Both systems were optimized to measure winds from Rayleigh backscatter at 355 nm. Simulations show that the measurement uncertainty during daytime is degraded by only approximately 10-20% compared with nighttime performance, provided that a proper solar filter is included in the instrument design.

  3. Direct laser written polymer waveguides with out of plane couplers for optical chips

    NASA Astrophysics Data System (ADS)

    Landowski, Alexander; Zepp, Dominik; Wingerter, Sebastian; von Freymann, Georg; Widera, Artur

    2017-10-01

    Optical technologies call for waveguide networks featuring high integration densities, low losses, and simple operation. Here, we present polymer waveguides fabricated from a negative tone photoresist via two-photon-lithography in direct laser writing, and show a detailed parameter study of their performance. Specifically, we produce waveguides featuring bend radii down to 40 μ m, insertion losses of the order of 10 dB, and loss coefficients smaller than 0.81 dB mm-1, facilitating high integration densities in writing fields of 300 μ m×300 μ m. A novel three-dimensional coupler design allows for coupling control as well as direct observation of outputs in a single field of view through a microscope objective. Finally, we present beam-splitting devices to construct larger optical networks, and we show that the waveguide material is compatible with the integration of quantum emitters.

  4. Orientation selectivity sharpens motion detection in Drosophila

    PubMed Central

    Fisher, Yvette E.; Silies, Marion; Clandinin, Thomas R.

    2015-01-01

    SUMMARY Detecting the orientation and movement of edges in a scene is critical to visually guided behaviors of many animals. What are the circuit algorithms that allow the brain to extract such behaviorally vital visual cues? Using in vivo two-photon calcium imaging in Drosophila, we describe direction selective signals in the dendrites of T4 and T5 neurons, detectors of local motion. We demonstrate that this circuit performs selective amplification of local light inputs, an observation that constrains motion detection models and confirms a core prediction of the Hassenstein-Reichardt Correlator (HRC). These neurons are also orientation selective, responding strongly to static features that are orthogonal to their preferred axis of motion, a tuning property not predicted by the HRC. This coincident extraction of orientation and direction sharpens directional tuning through surround inhibition and reveals a striking parallel between visual processing in flies and vertebrate cortex, suggesting a universal strategy for motion processing. PMID:26456048

  5. 42 CFR 414.60 - Payment for the services of CRNAs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... anesthesia service furnished by a CRNA, medically directed or not medically directed, is based on allowable... anesthesia service furnished by a medically directed CRNA is based on a fixed percentage of the allowance recognized for the anesthesia service personally performed by the physician alone, as specified in § 414.46(d...

  6. 42 CFR 414.60 - Payment for the services of CRNAs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... anesthesia service furnished by a CRNA, medically directed or not medically directed, is based on allowable... anesthesia service furnished by a medically directed CRNA is based on a fixed percentage of the allowance recognized for the anesthesia service personally performed by the physician alone, as specified in § 414.46(d...

  7. Sidelooking laser altimeter for a flight simulator

    NASA Technical Reports Server (NTRS)

    Webster, L. D. (Inventor)

    1983-01-01

    An improved laser altimeter for a flight simulator which allows measurement of the height of the simulator probe above the terrain directly below the probe tip is described. A laser beam is directed from the probe at an angle theta to the horizontal to produce a beam spot on the terrain. The angle theta that the laser beam makes with the horizontal is varied so as to bring the beam spot into coincidence with a plumb line coaxial with the longitudinal axis of the probe. A television altimeter camera observes the beam spot and has a raster line aligned with the plumb line. Spot detector circuit coupled to the output of the TV camera monitors the position of the beam spot relative to the plumb line.

  8. Waveform control of orientation-dependent ionization of DCl in few-cycle laser fields.

    PubMed

    Znakovskaya, I; von den Hoff, P; Schirmel, N; Urbasch, G; Zherebtsov, S; Bergues, B; de Vivie-Riedle, R; Weitzel, K-M; Kling, M F

    2011-05-21

    Strong few-cycle light fields with stable electric field waveforms allow controlling electrons on time scales down to the attosecond domain. We have studied the dissociative ionization of randomly oriented DCl in 5 fs light fields at 720 nm in the tunneling regime. Momentum distributions of D(+) and Cl(+) fragments were recorded via velocity-map imaging. A waveform-dependent anti-correlated directional emission of D(+) and Cl(+) fragments is observed. Comparison of our results with calculations indicates that tailoring of the light field via the carrier envelope phase permits the control over the orientation of DCl(+) and in turn the directional emission of charged fragments upon the breakup of the molecular ion. © The Owner Societies 2011

  9. Development and validation of the AmpFℓSTR® Identifiler® Direct PCR Amplification Kit: a multiplex assay for the direct amplification of single-source samples.

    PubMed

    Wang, Dennis Y; Chang, Chien-Wei; Lagacé, Robert E; Oldroyd, Nicola J; Hennessy, Lori K

    2011-07-01

    The AmpFℓSTR(®) Identifiler(®) Direct PCR Amplification Kit is a new short tandem repeat multiplex assay optimized to allow the direct amplification of single-source blood and buccal samples on FTA(®) card without the need for sample purification and quantification. This multiplex assay has been validated according to the FBI/National Standards and SWGDAM guidelines. Validation results revealed that slight variations in primer concentration, master mix component concentration, and thermal cycling parameters did not affect the performance of the chemistry. The assay's sensitivity was demonstrated by amplifying known amounts of white blood cells spotted onto FTA(®) cards, and the assay's specificity was verified by establishing minimal cross-reactivity with nonhuman DNA. No effect on the age of the sample stored on the FTA(®) substrate was observed and full concordance was established in the population study. These findings of the validation study support the use of the Identifiler(®) Direct Kit for forensic standards and database samples genotyping. © 2011 American Academy of Forensic Sciences.

  10. Mitigating direct detection bounds in non-minimal Higgs portal scalar dark matter models

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Subhaditya; Ghosh, Purusottam; Maity, Tarak Nath; Ray, Tirtha Sankar

    2017-10-01

    The minimal Higgs portal dark matter model is increasingly in tension with recent results form direct detection experiments like LUX and XENON. In this paper we make a systematic study of simple extensions of the Z_2 stabilized singlet scalar Higgs portal scenario in terms of their prospects at direct detection experiments. We consider both enlarging the stabilizing symmetry to Z_3 and incorporating multipartite features in the dark sector. We demonstrate that in these non-minimal models the interplay of annihilation, co-annihilation and semi-annihilation processes considerably relax constraints from present and proposed direct detection experiments while simultaneously saturating observed dark matter relic density. We explore in particular the resonant semi-annihilation channel within the multipartite Z_3 framework which results in new unexplored regions of parameter space that would be difficult to constrain by direct detection experiments in the near future. The role of dark matter exchange processes within multi-component Z_3× Z_3^' } framework is illustrated. We make quantitative estimates to elucidate the role of various annihilation processes in the different allowed regions of parameter space within these models.

  11. Disk Dispersal: Theoretical Understanding and Observational Constraints

    NASA Astrophysics Data System (ADS)

    Gorti, U.; Liseau, R.; Sándor, Z.; Clarke, C.

    2016-12-01

    Protoplanetary disks dissipate rapidly after the central star forms, on time-scales comparable to those inferred for planet formation. In order to allow the formation of planets, disks must survive the dispersive effects of UV and X-ray photoevaporation for at least a few Myr. Viscous accretion depletes significant amounts of the mass in gas and solids, while photoevaporative flows driven by internal and external irradiation remove most of the gas. A reasonably large fraction of the mass in solids and some gas get incorporated into planets. Here, we review our current understanding of disk evolution and dispersal, and discuss how these might affect planet formation. We also discuss existing observational constraints on dispersal mechanisms and future directions.

  12. Instrumentation and methodology for simultaneous excitation/detection of ions in an FTICR mass spectrometer

    PubMed

    Schmidt; Fiorentino; Arkin; Laude

    2000-08-01

    A method for direct and continuous detection of ion motion during different perturbation events of the fourier transform ion cyclotron resonance (FTICR) experiment is demonstrated. The modifications necessary to convert an ordinary FTICR cell into one capable of performing simultaneous excitation/detection (SED) using a capacitive network are outlined. With these modifications, a 200-fold reduction in the detection of the coupled excitation signal is achieved. This allows the unique ability not only to observe the response to the perturbation but to observe the perturbation event itself. SED is used successfully to monitor the ion cyclotron transient during single-frequency excitation, remeasurement and exciter-excite experiments.

  13. Interpretation of Cyclic Voltammetry Measurements of Thin Semiconductor Films for Solar Fuel Applications.

    PubMed

    Bertoluzzi, Luca; Badia-Bou, Laura; Fabregat-Santiago, Francisco; Gimenez, Sixto; Bisquert, Juan

    2013-04-18

    A simple model is proposed that allows interpretation of the cyclic voltammetry diagrams obtained experimentally for photoactive semiconductors with surface states or catalysts used for fuel production from sunlight. When the system is limited by charge transfer from the traps/catalyst layer and by detrapping, it is shown that only one capacitive peak is observable and is not recoverable in the return voltage scan. If the system is limited only by charge transfer and not by detrapping, two symmetric capacitive peaks can be observed in the cathodic and anodic directions. The model appears as a useful tool for the swift analysis of the electronic processes that limit fuel production.

  14. Regional-Scale Surface Magnetic Fields and Proton Fluxes to Mercury's Surface from Proton-Reflection Magnetometry

    NASA Astrophysics Data System (ADS)

    Winslow, R. M.; Johnson, C. L.; Anderson, B. J.; Gershman, D. J.; Raines, J. M.; Lillis, R. J.; Korth, H.; Slavin, J. A.; Solomon, S. C.; Zurbuchen, T.

    2014-12-01

    The application of a recently developed proton-reflection magnetometry technique to MESSENGER spacecraft observations at Mercury has yielded two significant findings. First, loss-cone observations directly confirm particle precipitation to Mercury's surface and indicate that solar wind plasma persistently bombards the planet not only in the magnetic cusp regions but over a large fraction of the southern hemisphere. Second, the inferred surface field strengths independently confirm the north-south asymmetry in Mercury's global magnetic field structure first documented from observations of magnetic equator crossings. Here we extend this work with 1.5 additional years of observations (i.e., to 2.5 years in all) to further probe Mercury's surface magnetic field and better resolve proton flux precipitation to the planet's surface. We map regions where proton loss cones are observed; these maps indicate regions where protons precipitate directly onto the surface. The augmentation of our data set over that used in our original study allows us to examine the proton loss cones in cells of dimension 10° latitude by 20° longitude in Mercury body-fixed coordinates. We observe a transition from double-sided to single-sided loss cones in the pitch-angle distributions; this transition marks the boundary between open and closed field lines. At the surface this boundary lies between 60° and 70°N. Our observations allow the estimation of surface magnetic field strengths in the northern cusp region and the calculation of incident proton fluxes to both hemispheres. In the northern cusp, our regional-scale observations are consistent with an offset dipole field and a dipole moment of 190 nT RM3, where RM is Mercury's radius, implying that any regional-scale variations in surface magnetic field strengths are either weak relative to the dipole field or occur at length scales smaller than the resolution of our observations (~300 km). From the global proton flux map (north of 40° S) derived from proton loss-cone measurements, we find an increase in proton flux near 0° and 180° planetary longitudes. This pattern is consistent with that expected from the combined effects of increased incident solar wind density at these longitudes at local noon (given the 3:2 spin-orbit resonance of Mercury) and phasing of MESSENGER's orbit.

  15. Non-invasive Brain Stimulation: A Paradigm Shift in Understanding Brain Oscillations.

    PubMed

    Vosskuhl, Johannes; Strüber, Daniel; Herrmann, Christoph S

    2018-01-01

    Cognitive neuroscience set out to understand the neural mechanisms underlying cognition. One central question is how oscillatory brain activity relates to cognitive processes. Up to now, most of the evidence supporting this relationship was correlative in nature. This situation changed dramatically with the recent development of non-invasive brain stimulation (NIBS) techniques, which open up new vistas for neuroscience by allowing researchers for the first time to validate their correlational theories by manipulating brain functioning directly. In this review, we focus on transcranial alternating current stimulation (tACS), an electrical brain stimulation method that applies sinusoidal currents to the intact scalp of human individuals to directly interfere with ongoing brain oscillations. We outline how tACS can impact human brain oscillations by employing different levels of observation from non-invasive tACS application in healthy volunteers and intracranial recordings in patients to animal studies demonstrating the effectiveness of alternating electric fields on neurons in vitro and in vivo . These findings likely translate to humans as comparable effects can be observed in human and animal studies. Neural entrainment and plasticity are suggested to mediate the behavioral effects of tACS. Furthermore, we focus on mechanistic theories about the relationship between certain cognitive functions and specific parameters of brain oscillaitons such as its amplitude, frequency, phase and phase coherence. For each of these parameters we present the current state of testing its functional relevance by means of tACS. Recent developments in the field of tACS are outlined which include the stimulation with physiologically inspired non-sinusoidal waveforms, stimulation protocols which allow for the observation of online-effects, and closed loop applications of tACS.

  16. Control over Janus micromotors by the strength of a magnetic field

    NASA Astrophysics Data System (ADS)

    Baraban, Larysa; Makarov, Denys; Schmidt, Oliver G.; Cuniberti, Gianaurelio; Leiderer, Paul; Erbe, Artur

    2013-01-01

    For transportation of molecules or biological cells using artificial motors, the control over their motion, i.e. direction and speed of transfer, is important. Here, we demonstrate that modification of the velocity and orientation of a magnetic Janus particle can be efficiently controlled by tuning the strength of an applied homogeneous magnetic field. Interestingly, by keeping the same orientation of the magnetic field but changing its magnitude not only the velocity of capped particles can be altered but even their direction of motion can be reversed. We put forth a simple qualitative model, which allows us to explain this intriguing observation.For transportation of molecules or biological cells using artificial motors, the control over their motion, i.e. direction and speed of transfer, is important. Here, we demonstrate that modification of the velocity and orientation of a magnetic Janus particle can be efficiently controlled by tuning the strength of an applied homogeneous magnetic field. Interestingly, by keeping the same orientation of the magnetic field but changing its magnitude not only the velocity of capped particles can be altered but even their direction of motion can be reversed. We put forth a simple qualitative model, which allows us to explain this intriguing observation. Electronic supplementary information (ESI) available: Videos (1-3) describe the behavior of the magnetic Janus micromotors at different magnetic fields applied. The magnetic field is always applied along the positive direction of the y-axis. All the movies are recorded at the same frame rate of 21 images per second. Experiments were performed at 30 wt% of hydrogen peroxide in aqueous solution. Video 1 shows the motion of the Janus micromotors when a small magnetic field is applied (B = 0.2 mT). The particle is propelled in the direction ``opposite to the cap'' with a velocity of about 6 μm s-1. Video 2 displays the motion of the same Janus bead when an intermediately strong magnetic field is applied (B = 1.5 mT). The particle still moves in the direction ``opposite to the cap'', but with a much smaller velocity of about 1 μm s-1. Video 3 shows the behavior of the Janus micromotor, exposed to the high magnetic field B = 2.2 mT. The particle moves in the direction ``towards the cap'' with the speed of about 4 μm s-1. See DOI: 10.1039/c2nr32662k

  17. Electric field-induced emission enhancement and modulation in individual CdSe nanowires.

    PubMed

    Vietmeyer, Felix; Tchelidze, Tamar; Tsou, Veronica; Janko, Boldizsar; Kuno, Masaru

    2012-10-23

    CdSe nanowires show reversible emission intensity enhancements when subjected to electric field strengths ranging from 5 to 22 MV/m. Under alternating positive and negative biases, emission intensity modulation depths of 14 ± 7% are observed. Individual wires are studied by placing them in parallel plate capacitor-like structures and monitoring their emission intensities via single nanostructure microscopy. Observed emission sensitivities are rationalized by the field-induced modulation of carrier detrapping rates from NW defect sites responsible for nonradiative relaxation processes. The exclusion of these states from subsequent photophysics leads to observed photoluminescence quantum yield enhancements. We quantitatively explain the phenomenon by developing a kinetic model to account for field-induced variations of carrier detrapping rates. The observed phenomenon allows direct visualization of trap state behavior in individual CdSe nanowires and represents a first step toward developing new optical techniques that can probe defects in low-dimensional materials.

  18. In-situ Crystallization of Highly Volatile Commercial Mold Flux Using an Isolated Observation System in the Confocal Laser Scanning Microscope

    NASA Astrophysics Data System (ADS)

    Park, Jun-Yong; Ryu, Jae Wook; Sohn, Il

    2014-08-01

    The in situ crystallization behavior of highly volatile commercial mold fluxes for medium carbon steels was investigated using the confocal laser scanning microscope (CLSM) equipped with an optimized isolated observation system. The highly volatile compounds of the mold flux were suppressed during heating allowing direct observation in the CLSM. Cooling rates of 25, 50, 100, 400, and 800 K/min were incorporated and continuous cooling transformation (CCT) diagrams of 4 different commercial mold fluxes for medium carbon steels were developed. Identification of the crystalline phase was conducted with XRD and SEM-EDS analysis. A cuspidine crystalline was observed in all samples at various cooling rates. With higher basicity, CaF2, and NaF, the crystallization of the fluxes was enhanced according to the CCT diagram. As the slag structure becomes depolymerized, the diffusion rate of the cathodic ions seems to increase.

  19. The wide-spread presence of rib-like patterns in basal shear of ice streams detected by surface data inversion

    NASA Astrophysics Data System (ADS)

    Sergienko, O. V.

    2013-12-01

    The direct observations of the basal conditions under continental-scale ice sheets are logistically impossible. A possible approach to estimate conditions at the ice - bed interface is from surface observations by means of inverse methods. The recent advances in remote and ground-based observations have allowed to acquire a wealth observations from Greenland and Antarctic ice sheets. Using high-resolution data sets of ice surface and bed elevations and surface velocities, inversions for basal conditions have been performed for several ice streams in Greenland and Antarctica. The inversion results reveal the wide-spread presence of rib-like spatial structures in basal shear. The analysis of the hydraulic potential distribution shows that these rib-like structures co-locate with highs of the gradient of hydraulic potential. This suggests that subglacial water plays a role in the development and evolution of the basal shear ribs.

  20. Social learning of diet and foraging skills by wild immature Bornean orangutans: implications for culture.

    PubMed

    Jaeggi, Adrian V; Dunkel, Lynda P; Van Noordwijk, Maria A; Wich, Serge A; Sura, Agnes A L; Van Schaik, Carel P

    2010-01-01

    Studies of social learning in the wild are important to complement findings from experiments in captivity. In this field study, immature Bornean orangutans rarely foraged independently but consistently followed their mothers' choices. Their diets were essentially identical to their mothers' even though not all mothers had the same diet. This suggests vertical transmission of diet by enhancement. Also, immatures selectively observed their mothers during extractive foraging, which increased goal-directed practice but not general manipulation of similar objects, suggesting observational forms of learning of complex skills. Teaching was not observed. These results are consistent with the reported presence of food traditions and skill cultures in wild orangutans. We suggest that food traditions can develop wherever association commonly allows for social learning. However, the capacity for observational learning, and thus more complex culture, is more likely to evolve among extractive foragers with prolonged association between adults and immatures. (c) 2009 Wiley-Liss, Inc.

  1. Arabidopsis thaliana polyamine content is modified by the interaction with different Trichoderma species.

    PubMed

    Salazar-Badillo, Fatima Berenice; Sánchez-Rangel, Diana; Becerra-Flora, Alicia; López-Gómez, Miguel; Nieto-Jacobo, Fernanda; Mendoza-Mendoza, Artemio; Jiménez-Bremont, Juan Francisco

    2015-10-01

    Plants are associated with a wide range of microorganisms throughout their life cycle, and some interactions result on plant benefits. Trichoderma species are plant beneficial fungi that enhance plant growth and development, contribute to plant nutrition and induce defense responses. Nevertheless, the molecules involved in these beneficial effects still need to be identify. Polyamines are ubiquitous molecules implicated in plant growth and development, and in the establishment of plant microbe interactions. In this study, we assessed the polyamine profile in Arabidopsis plants during the interaction with Trichoderma virens and Trichoderma atroviride, using a system that allows direct plant-fungal contact or avoids their physical interaction (split system). The plantlets that grew in the split system exhibited higher biomass than the ones in direct contact with Trichoderma species. After 3 days of interaction, a significant decrease in Arabidopsis polyamine levels was observed in both systems (direct contact and split). After 5 days of interaction polyamine levels were increased. The highest levels were observed with T. atroviride (split system), and with T. virens (direct contact). The expression levels of Arabidopsis ADC1 and ADC2 genes during the interaction with the fungi were also assessed. We observed a time dependent regulation of ADC1 and ADC2 genes, which correlates with polyamine levels. Our data show an evident change in polyamine profile during Arabidopsis - Trichoderma interaction, accompanied by evident alterations in plant root architecture. Polyamines could be involved in the changes undergone by plant during the interaction with this beneficial fungus. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  2. Strike-Slip Fault Patterns on Europa: Obliquity or Polar Wander?

    NASA Technical Reports Server (NTRS)

    Rhoden, Alyssa Rose; Hurford, Terry A.; Manga, Michael

    2011-01-01

    Variations in diurnal tidal stress due to Europa's eccentric orbit have been considered as the driver of strike-slip motion along pre-existing faults, but obliquity and physical libration have not been taken into account. The first objective of this work is to examine the effects of obliquity on the predicted global pattern of fault slip directions based on a tidal-tectonic formation model. Our second objective is to test the hypothesis that incorporating obliquity can reconcile theory and observations without requiring polar wander, which was previously invoked to explain the mismatch found between the slip directions of 192 faults on Europa and the global pattern predicted using the eccentricity-only model. We compute predictions for individual, observed faults at their current latitude, longitude, and azimuth with four different tidal models: eccentricity only, eccentricity plus obliquity, eccentricity plus physical libration, and a combination of all three effects. We then determine whether longitude migration, presumably due to non-synchronous rotation, is indicated in observed faults by repeating the comparisons with and without obliquity, this time also allowing longitude translation. We find that a tidal model including an obliquity of 1.2?, along with longitude migration, can predict the slip directions of all observed features in the survey. However, all but four faults can be fit with only 1? of obliquity so the value we find may represent the maximum departure from a lower time-averaged obliquity value. Adding physical libration to the obliquity model improves the accuracy of predictions at the current locations of the faults, but fails to predict the slip directions of six faults and requires additional degrees of freedom. The obliquity model with longitude migration is therefore our preferred model. Although the polar wander interpretation cannot be ruled out from these results alone, the obliquity model accounts for all observations with a value consistent with theoretical expectations and cycloid modeling.

  3. Predicting Flow Reversals in a Computational Fluid Dynamics Simulated Thermosyphon Using Data Assimilation.

    PubMed

    Reagan, Andrew J; Dubief, Yves; Dodds, Peter Sheridan; Danforth, Christopher M

    2016-01-01

    A thermal convection loop is a annular chamber filled with water, heated on the bottom half and cooled on the top half. With sufficiently large forcing of heat, the direction of fluid flow in the loop oscillates chaotically, dynamics analogous to the Earth's weather. As is the case for state-of-the-art weather models, we only observe the statistics over a small region of state space, making prediction difficult. To overcome this challenge, data assimilation (DA) methods, and specifically ensemble methods, use the computational model itself to estimate the uncertainty of the model to optimally combine these observations into an initial condition for predicting the future state. Here, we build and verify four distinct DA methods, and then, we perform a twin model experiment with the computational fluid dynamics simulation of the loop using the Ensemble Transform Kalman Filter (ETKF) to assimilate observations and predict flow reversals. We show that using adaptively shaped localized covariance outperforms static localized covariance with the ETKF, and allows for the use of less observations in predicting flow reversals. We also show that a Dynamic Mode Decomposition (DMD) of the temperature and velocity fields recovers the low dimensional system underlying reversals, finding specific modes which together are predictive of reversal direction.

  4. Predicting Flow Reversals in a Computational Fluid Dynamics Simulated Thermosyphon Using Data Assimilation

    PubMed Central

    Reagan, Andrew J.; Dubief, Yves; Dodds, Peter Sheridan; Danforth, Christopher M.

    2016-01-01

    A thermal convection loop is a annular chamber filled with water, heated on the bottom half and cooled on the top half. With sufficiently large forcing of heat, the direction of fluid flow in the loop oscillates chaotically, dynamics analogous to the Earth’s weather. As is the case for state-of-the-art weather models, we only observe the statistics over a small region of state space, making prediction difficult. To overcome this challenge, data assimilation (DA) methods, and specifically ensemble methods, use the computational model itself to estimate the uncertainty of the model to optimally combine these observations into an initial condition for predicting the future state. Here, we build and verify four distinct DA methods, and then, we perform a twin model experiment with the computational fluid dynamics simulation of the loop using the Ensemble Transform Kalman Filter (ETKF) to assimilate observations and predict flow reversals. We show that using adaptively shaped localized covariance outperforms static localized covariance with the ETKF, and allows for the use of less observations in predicting flow reversals. We also show that a Dynamic Mode Decomposition (DMD) of the temperature and velocity fields recovers the low dimensional system underlying reversals, finding specific modes which together are predictive of reversal direction. PMID:26849061

  5. Impact localization on composite structures using time difference and MUSIC approach

    NASA Astrophysics Data System (ADS)

    Zhong, Yongteng; Xiang, Jiawei

    2017-05-01

    1-D uniform linear array (ULA) has the shortcoming of the half-plane mirror effect, which does not allow discriminating between a target placed above the array and a target placed below the array. This paper presents time difference (TD) and multiple signal classification (MUSIC) based omni-directional impact localization on a large stiffened composite structure using improved linear array, which is able to perform omni-directional 360° localization. This array contains 2M+3 PZT sensors, where 2M+1 PZT sensors are arranged as a uniform linear array, and the other two PZT sensors are placed above and below the array. Firstly, the arrival times of impact signals observed by the other two sensors are determined using the wavelet transform. Compared with each other, the direction range of impact source can be decided in general, 0°to 180° or 180°to 360°. And then, two dimensional multiple signal classification (2D-MUSIC) based spatial spectrum formula using the uniform linear array is applied for impact localization by the general direction range. When the arrival times of impact signals observed by upper PZT is equal to that of lower PZT, the direction can be located in x axis (0°or 180°). And time difference based MUSIC method is present to locate impact position. To verify the proposed approach, the proposed approach is applied to a composite structure. The localization results are in good agreement with the actual impact occurring positions.

  6. Prospects of light sterile neutrino oscillation and C P violation searches at the Fermilab Short Baseline Neutrino Facility

    NASA Astrophysics Data System (ADS)

    Cianci, D.; Furmanski, A.; Karagiorgi, G.; Ross-Lonergan, M.

    2017-09-01

    We investigate the ability of the short baseline neutrino (SBN) experimental program at Fermilab to test the globally-allowed (3 +N ) sterile neutrino oscillation parameter space. We explicitly consider the globally-allowed parameter space for the (3 +1 ), (3 +2 ), and (3 +3 ) sterile neutrino oscillation scenarios. We find that SBN can probe with 5 σ sensitivity more than 85%, 95% and 55% of the parameter space currently allowed at 99% confidence level for the (3 +1 ), (3 +2 ) and (3 +3 ) scenarios, respectively, with the (3 +N ) allowed space used in these studies closely resembling that of previous studies [J. M. Conrad, C. M. Ignarra, G. Karagiorgi, M. H. Shaevitz, and J. Spitz, Adv. High Energy Phys. 2013, 1 (2013)., 10.1155/2013/163897], calculated using the same methodology. In the case of the (3 +2 ) and (3 +3 ) scenarios, C P -violating phases appear in the oscillation probability terms, leading to observable differences in the appearance probabilities of neutrinos and antineutrinos. We explore SBN's sensitivity to those phases for the (3 +2 ) scenario through the currently planned neutrino beam running, and investigate potential improvements through additional antineutrino beam running. We show that, if antineutrino exposure is considered, for maximal values of the (3 +2 ) C P -violating phase ϕ54, SBN could be the first experiment to directly observe ˜2 σ hints of C P violation associated with an extended lepton sector.

  7. The Soil Moisture Active and Passive (SMAP) Mission

    NASA Technical Reports Server (NTRS)

    Entekhabi, Dara; Nijoku, Eni G.; ONeill, Peggy E.; Kellogg, Kent H.; Crow, Wade T.; Edelstein, Wendy N.; Entin, Jared K.; Goodman, Shawn D.; Jackson, Thomas J.; Johnson, Joel; hide

    2009-01-01

    The Soil Moisture Active and Passive (SMAP) Mission is one of the first Earth observation satellites being developed by NASA in response to the National Research Council s Decadal Survey. SMAP will make global measurements of the moisture present at Earth's land surface and will distinguish frozen from thawed land surfaces. Direct observations of soil moisture and freeze/thaw state from space will allow significantly improved estimates of water, energy and carbon transfers between land and atmosphere. Soil moisture measurements are also of great importance in assessing flooding and monitoring drought. SMAP observations can help mitigate these natural hazards, resulting in potentially great economic and social benefits. SMAP soil moisture and freeze/thaw timing observations will also reduce a major uncertainty in quantifying the global carbon balance by helping to resolve an apparent missing carbon sink on land over the boreal latitudes. The SMAP mission concept would utilize an L-band radar and radiometer. These instruments will share a rotating 6-meter mesh reflector antenna to provide high-resolution and high-accuracy global maps of soil moisture and freeze/thaw state every two to three days. The SMAP instruments provide direct measurements of surface conditions. In addition, the SMAP project will use these observations with advanced modeling and data assimilation to provide deeper root-zone soil moisture and estimates of land surface-atmosphere exchanges of water, energy and carbon. SMAP is scheduled for a 2014 launch date

  8. Coronal Current Sheet Evolution in the Aftermath of a CME

    NASA Technical Reports Server (NTRS)

    Bemporad, A.; Poletto, G.; Suess, S. T.; Ko, Y.-K.; Schwadron, N. A.; Elliott, H. A.; Raymond, J. C.

    2005-01-01

    We report on SOHO-UVCS observations of coronal restructuring following a Coronal Mass Ejection (CME) on November 26, 2002, at the time of a SOHO-Ulysses quadrature campaign. Starting about 3 hours after the CME, which was directed towards Ulysses, UVCS began taking spectra at 1.7 solar radii, covering emission from both cool and hot plasma. Observations continued, with occasional gaps, for more than 2 days. Emission in the 974.8 Angstrom line of [Fe XVIII], indicating temperatures above 6x10(6) K, was observed throughout the campaign in a spatially limited location. Comparison with EIT images shows the [Fe XVIII] emission to overlie a growing post-flare loop system formed in the aftermath of the CME. The emission most likely originates in a current sheet overlying the arcade. Analysis of the [Fe XVIII] emission allows us to infer the evolution of physical parameters in the current sheet over the entire span of our observations: in particular, we give the temperature vs. time in the current sheet and estimate the density. Ulysses was directly above the location of the CME and intercepted the ejecta. High ionization state Fe was detected by SWICS throughout the magnetic cloud associated with the CME, although the rapid temporal variation suggests bursty, rather than smooth, reconnection in the coronal current sheet. Both the remote and in situ observations are compared with predictions of theoretical CME models.

  9. Digital direct electron imaging of energy-filtered electron backscatter diffraction patterns

    NASA Astrophysics Data System (ADS)

    Vespucci, S.; Winkelmann, A.; Naresh-Kumar, G.; Mingard, K. P.; Maneuski, D.; Edwards, P. R.; Day, A. P.; O'Shea, V.; Trager-Cowan, C.

    2015-11-01

    Electron backscatter diffraction is a scanning electron microscopy technique used to obtain crystallographic information on materials. It allows the nondestructive mapping of crystal structure, texture, and strain with a lateral and depth resolution on the order of tens of nanometers. Electron backscatter diffraction patterns (EBSPs) are presently acquired using a detector comprising a scintillator coupled to a digital camera, and the crystallographic information obtainable is limited by the conversion of electrons to photons and then back to electrons again. In this article we will report the direct acquisition of energy-filtered EBSPs using a digital complementary metal-oxide-semiconductor hybrid pixel detector, Timepix. We show results from a range of samples with different mass and density, namely diamond, silicon, and GaN. Direct electron detection allows the acquisition of EBSPs at lower (≤5 keV) electron beam energies. This results in a reduction in the depth and lateral extension of the volume of the specimen contributing to the pattern and will lead to a significant improvement in lateral and depth resolution. Direct electron detection together with energy filtering (electrons having energy below a specific value are excluded) also leads to an improvement in spatial resolution but in addition provides an unprecedented increase in the detail in the acquired EBSPs. An increase in contrast and higher-order diffraction features are observed. In addition, excess-deficiency effects appear to be suppressed on energy filtering. This allows the fundamental physics of pattern formation to be interrogated and will enable a step change in the use of electron backscatter diffraction (EBSD) for crystal phase identification and the mapping of strain. The enhancement in the contrast in high-pass energy-filtered EBSD patterns is found to be stronger for lighter, less dense materials. The improved contrast for such materials will enable the application of the EBSD technique to be expanded to materials for which conventional EBSD analysis is not presently practicable.

  10. In vitro studies of the blood-brain barrier using isolated brain capillaries and cultured endothelial cells.

    PubMed

    Goldstein, G W; Betz, A L; Bowman, P D; Dorovini-Zis, K

    1986-01-01

    The endothelial cells in brain capillaries are the anatomic site of the blood-brain barrier. To learn more about the biology of these specialized cells, we developed methods to prepare suspensions of purified brain microvessels as well as primary cultures of endothelial cells in monolayer. These two preparations allow for direct investigation of the metabolism, transport properties, and receptor content of the brain capillary. We used isolated brain microvessels to study distribution of membrane carriers between the luminal and the abluminal plasma membrane of endothelial cells. We found that Na+K+-ATPase and the A-system amino-acid transport system are located predominantly on the abluminal surface of brain capillary endothelial cells. This distribution of transport carriers is consistent with the low permeability of potassium and small neutral amino acids in the blood-to-brain direction. It suggests, however, that both solutes can be actively transported across brain capillaries from the brain interstitial fluid to the blood. In tissue culture, the endothelial cells form continuous tight junctions with their neighbors. This results in a cellular layer impermeable to protein tracers. When exposed to hyperosmolar solutions, in an attempt to mimic the conditions that open the blood-brain barrier in vivo, we found a reversible separation of the tight junctions between contiguous endothelial cells. No indication of activation of pinocytosis was observed. In vitro systems provide a novel approach for studying the function of the blood-brain barrier and allow for observations not possible with intact animals.

  11. Controversies in psychotherapy research: epistemic differences in assumptions about human psychology.

    PubMed

    Shean, Glenn D

    2013-01-01

    It is the thesis of this paper that differences in philosophical assumptions about the subject matter and treatment methods of psychotherapy have contributed to disagreements about the external validity of empirically supported therapies (ESTs). These differences are evident in the theories that are the basis for both the design and interpretation of recent psychotherapy efficacy studies. The natural science model, as applied to psychotherapy outcome research, transforms the constitutive features of the study subject in a reciprocal manner so that problems, treatments, and indicators of effectiveness are limited to what can be directly observed. Meaning-based approaches to therapy emphasize processes and changes that do not lend themselves to experimental study. Hermeneutic philosophy provides a supplemental model to establishing validity in those instances where outcome indicators do not lend themselves to direct observation and measurement and require "deep" interpretation. Hermeneutics allows for a broadening of psychological study that allows one to establish a form of validity that is applicable when constructs do not refer to things that literally "exist" in nature. From a hermeneutic perspective the changes that occur in meaning-based therapies must be understood and evaluated on the manner in which they are applied to new situations, the logical ordering and harmony of the parts with the theoretical whole, and the capability of convincing experts and patients that the interpretation can stand up against other ways of understanding. Adoption of this approach often is necessary to competently evaluate the effectiveness of meaning-based therapies.

  12. Direct peroral cholangioscopy using an ultrathin endoscope: making technique easier.

    PubMed

    Sola-Vera, Javier; Uceda, Francisco; Cuesta, Rubén; Vázquez, Narcís

    2014-01-01

    Cholangioscopy is a useful tool for the study and treatment of biliary pathology. Ultrathin upper endoscopes allow direct peroral cholangioscopy (DPC) but have some drawbacks. The aim of the study was to evaluate the success rate of DPC with an ultrathin endoscope using a balloon catheter to reach the biliary confluence. Prospective observational study. An ultrathin endoscope (Olympus XP180N, outer diameter 5.5 mm, working channel 2 mm) was used. To access the biliary tree, free-hand technique was used. To reach the biliary confluence an intraductal balloon catheter (Olympus B5-2Q diameter 1.9 mm) and a 0.025 inch guide wire was used. In all cases sphincterotomy and/or sphincteroplasty was performed. The success rate was defined as the percentage of cases in which the biliary confluence could be reached with the ultrathin endoscope. Fifteen patients (8 men/7 women) were included. Mean age was 77.7 + or - 10.8 years (range 45-91). The indications for cholangioscopy were suspected bile duct stones (n = 9), electrohydraulic lithotripsy for the treatment of difficult choledocholithiasis (n = 5) and evaluation of biliary stricture (n = 1). Access to the bile duct was achieved in 14/15 cases (93.3%). Biliary confluence was reached in 13/15 cases (86.7%). One complication was observed in one patient (oxigen desaturation). DPC with an ultrathin endoscope can be done with the free-hand technique. Intraductal balloon-guided DPC allows full examination of the common bile duct in most cases.

  13. Distances, Kinematics, And Structure Of The Orion Complex

    NASA Astrophysics Data System (ADS)

    Kounkel, Marina; Hartmann, Lee

    2018-01-01

    I present an analysis of the structure and kinematics of the Orion Molecular Cloud Complex in an effort to better characterize the dynamical state of the closest region of ongoing massive star formation. I measured stellar parallax and proper motions with <5% uncertainty using radio VLBI observations of non-thermally-emitting sources located in various star forming regions within the Orion Complex. This includes the first direct distance measurements for sources that are located outside of the Orion Nebula. I identified a number of binary systems in the VLBI dataset and fitted their orbital motion, which allows for the direct measurement of the masses of the individual components. Additionally, I have identified several stars that have been ejected from the Orion Nebula due to strong gravitational interactions with the most massive members. I complemented the parallax and proper motion measurements with the observations of optical radial velocities of the stars toward the Orion Complex, probing the histories of both dynamic evolution and star formation in the region, providing a 6-dimensional model of the Complex. These observations can serve as a baseline for comparison of the upcoming results from the Gaia space telescope

  14. Photodegradation of novel oral anticoagulants under sunlight irradiation in aqueous matrices.

    PubMed

    Yassine, Montaha; Fuster, Laura; Dévier, Marie-Hélène; Geneste, Emmanuel; Pardon, Patrick; Grélard, Axelle; Dufourc, Erick; Al Iskandarani, Mohamad; Aït-Aïssa, Selim; Garric, Jeanne; Budzinski, Hélène; Mazellier, Patrick; Trivella, Aurélien S

    2018-02-01

    Kinetics of photodegradation of novel oral anticoagulants dabigatran, rivaroxaban, and apixaban were studied under simulated solar light irradiation in purified, mineral, and river waters. Dabigatran and rivaroxaban underwent direct photolysis with polychromatic quantum yields of 2.2 × 10 -4 and 4.4 × 10 -2 , respectively. The direct photodegradation of apixaban was not observed after 19 h of irradiation. Kinetics of degradation of rivaroxaban was not impacted by the nature of the aqueous matrix while photosensitization from nitrate ions was observed for dabigatran and apixaban dissolved in a mineral water. The photosensitized reactions were limited in the tested river water (Isle River, Périgueux, France) certainly due to the hydroxyl radical scavenging effect of the dissolved organic matter. The study of photoproduct structures allowed to identify two compounds for dabigatran. One of them is the 4-aminobenzamidine while the second one is a cyclization product. In the case of rivaroxaban, as studied by very high field NMR, only one photoproduct was observed i.e. a photoisomer. Finally, seven photoproducts were clearly identified from the degradation of apixaban under simulated solar light. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Thin film metal thermistors with microsecond time response for shock temperature measurements of polymers

    NASA Astrophysics Data System (ADS)

    Taylor, Nicholas; Williamson, David; Jardine, Andrew

    2013-06-01

    Equations of state can be used to predict the relationship between pressure, volume and temperature. However, in shock physics, they are usually only constrained by experimental observations of pressure and volume. Direct observation of temperature in a shock is therefore valuable in constraining equations of state. Bloomquist and Sheffield (1980, 1981) and Rosenberg and Partom (1984) have attempted such observations in PMMA. However, their results disagree strongly above 2 GPa shock pressure. Here we present an improved fabrication technique, to examine this outstanding issue. We make use of the fact that the electrical resistivity of most metals is a known function of both pressure and temperature. If the change in resistance of a thin metal thermistor gauge is measured during a shock experiment of known pressure, the temperature can be calculated directly. The time response is limited by the time taken for the gauge to reach thermal equilibrium with the medium in which it is embedded. Gold gauges of thickness up to 200 nm have been produced by evaporation, and fully embedded in PMMA. These reach thermal equilibrium with the host material in under 1 μs, allowing temperature measurement within the duration of a plate impact experiment.

  16. Direct observation of shear piezoelectricity in poly-l-lactic acid nanowires

    NASA Astrophysics Data System (ADS)

    Smith, Michael; Calahorra, Yonatan; Jing, Qingshen; Kar-Narayan, Sohini

    2017-07-01

    Piezoelectric polymers are capable of interconverting mechanical and electrical energy, and are therefore candidate materials for biomedical applications such as sensors, actuators, and energy harvesters. In particular, nanowires of these materials are attractive as they can be unclamped, flexible and sensitive to small vibrations. Poly-l-lactic acid (PLLA) nanowires have been investigated for their use in biological applications, but their piezoelectric properties have never been fully characterised, even though macroscopic films and fibres have been shown to exhibit shear piezoelectricity. This piezoelectric mode is particularly interesting for in vivo applications where shear forces are especially relevant, and is similar to what has been observed in natural materials such as bone and DNA. Here, using piezo-response force microscopy (PFM), we report the first direct observation of shear piezoelectricity in highly crystalline and oriented PLLA nanowires grown by a novel template-wetting method. Our results are validated using finite-element simulations and numerical analysis, which importantly and more generally allow for accurate interpretation of PFM signals in soft nanostructured materials. Our work opens up the possibility for the development of biocompatible and sustainable piezoelectric nanogenerators and sensors based on polymer nanowires.

  17. Radio Receiver Instrument (RRI) ePOP transionospheric observations from an HF transmitter in Ottawa (45N, 75W)

    NASA Astrophysics Data System (ADS)

    Hussey, G. C.; Danskin, D. W.; Gillies, R. G.; James, H. G.; Yau, A. W.; Hird, F. C.; Fairbairn, D. T.

    2016-12-01

    A ground-based HF transmitter operating at 10.422 MHz in Ottawa, Canada (45.4N, 75.6W) was the radio source for reception by the satellite-based Radio Receiver Instrument (RRI) for 5 passes in late April, 2016. The RRI is one of eight instruments on the enhanced Polar Outflow Probe (ePOP) scientific payload portion of the CSA (Canadian Space Agency) CASSIOPE (Cascade Demonstrator Small-Sat and Ionospheric Polar Explorer) satellite mission launched in September, 2013. The crossed-dipole configuration of the RRI allows for complete polarization observations. Initial analysis of the passes indicates reception of a highly polarized signal. South of the transmitter the signal clearly exhibits Faraday rotation of an essentially linearly polarized radio wave in agreement with modeling by Gillies et al. [2007]. This propagation is characterized as quasi-longitudinal (QL) by the Appleton-Hartree equation (electromagnetic wave propagation in a cold magnetized plasma) as the radio waves travel in a direction more along the magnetic field of the Earth. When the satellite moves north of the Ottawa transmitter the radio wave propagation transitions into quasi-transverse (QT). The data indicates favoring circular polarization dependent on the geometry with respect to the transmitter. Surprisingly the Faraday rotation effect is still very pronounced reversing in direction roughly 1000 km north of the transmitter. The model of Gillies et al. [2007] has been extended to explain these observations. This is the first direct observation, by polarimetry, of HF radio wave propagation in near-Earth space plasmas.Gillies, R.G., G.C. Hussey, H.G. James, G.J. Sofko, and D. Andre, Modelling and observation of transionospheric propagation results from ISIS II in preparation for ePOP, Ann. Geophys. 25, 87-97, 2007.

  18. Separate and Simultaneous Adjustment of Light Qualities in a Real Scene

    PubMed Central

    Pont, Sylvia C.; Heynderick, Ingrid

    2017-01-01

    Humans are able to estimate light field properties in a scene in that they have expectations of the objects’ appearance inside it. Previously, we probed such expectations in a real scene by asking whether a “probe object” fitted a real scene with regard to its lighting. But how well are observers able to interactively adjust the light properties on a “probe object” to its surrounding real scene? Image ambiguities can result in perceptual interactions between light properties. Such interactions formed a major problem for the “readability” of the illumination direction and diffuseness on a matte smooth spherical probe. We found that light direction and diffuseness judgments using a rough sphere as probe were slightly more accurate than when using a smooth sphere, due to the three-dimensional (3D) texture. We here extended the previous work by testing independent and simultaneous (i.e., the light field properties separated one by one or blended together) adjustments of light intensity, direction, and diffuseness using a rough probe. Independently inferred light intensities were close to the veridical values, and the simultaneously inferred light intensity interacted somewhat with the light direction and diffuseness. The independently inferred light directions showed no statistical difference with the simultaneously inferred directions. The light diffuseness inferences correlated with but contracted around medium veridical values. In summary, observers were able to adjust the basic light properties through both independent and simultaneous adjustments. The light intensity, direction, and diffuseness are well “readable” from our rough probe. Our method allows “tuning the light” (adjustment of its spatial distribution) in interfaces for lighting design or perception research. PMID:28203350

  19. Reconstructing WIMP properties through an interplay of signal measurements in direct detection, Fermi-LAT, and CTA searches for dark matter

    NASA Astrophysics Data System (ADS)

    Roszkowski, Leszek; Sessolo, Enrico Maria; Trojanowski, Sebastian; Williams, Andrew J.

    2016-08-01

    We examine the projected ability to reconstruct the mass, scattering, and annihilation cross section of dark matter in the new generation of large underground detectors, XENON-1T, SuperCDMS, and DarkSide-G2, in combination with diffuse gamma radiation from expected 15 years of data from Fermi-LAT observation of 46 local spiral dwarf galaxies and projected CTA sensitivity to a signal from the Galactic Center. To this end we consider several benchmark points spanning a wide range of WIMP mass, different annihilation final states, and large enough event rates to warrant detection in one or more experiments. As previously shown, below some 100 GeV only direct detection experiments will in principle be able to reconstruct WIMP mass well. This may, in case a signal at Fermi-LAT is also detected, additionally help restricting σv and the allowed decay branching rates. In the intermediate range between some 100 GeV and up a few hundred GeV, direct and indirect detection experiments can be used in complementarity to ameliorate the respective determinations, which in individual experiments can at best be rather poor, thus making the WIMP reconstruction in this mass range very challenging. At large WIMP mass, ~ 1 TeV, CTA will have the ability to reconstruct mass, annihilation cross section, and the allowed decay branching rates to very good precision for the τ+τ- or purely leptonic final state, good for the W+W- case, and rather poor for bbar b. A substantial improvement can potentially be achieved by reducing the systematic uncertainties, increasing exposure, or by an additional measurement at Fermi-LAT that would help reconstruct the annihilation cross section and the allowed branching fractions to different final states.

  20. Instrumentino: An Open-Source Software for Scientific Instruments.

    PubMed

    Koenka, Israel Joel; Sáiz, Jorge; Hauser, Peter C

    2015-01-01

    Scientists often need to build dedicated computer-controlled experimental systems. For this purpose, it is becoming common to employ open-source microcontroller platforms, such as the Arduino. These boards and associated integrated software development environments provide affordable yet powerful solutions for the implementation of hardware control of transducers and acquisition of signals from detectors and sensors. It is, however, a challenge to write programs that allow interactive use of such arrangements from a personal computer. This task is particularly complex if some of the included hardware components are connected directly to the computer and not via the microcontroller. A graphical user interface framework, Instrumentino, was therefore developed to allow the creation of control programs for complex systems with minimal programming effort. By writing a single code file, a powerful custom user interface is generated, which enables the automatic running of elaborate operation sequences and observation of acquired experimental data in real time. The framework, which is written in Python, allows extension by users, and is made available as an open source project.

  1. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSats: New soft X-ray spectrometer to investigate properties of hot plasma in the quiet Sun, active regions, and flares.

    NASA Astrophysics Data System (ADS)

    Moore, C. S.; Dennis, B. R.; Woods, T. N.

    2017-12-01

    Detection of soft X-rays from the Sun provides direct information on coronal plasma at temperatures in excess of 1 MK. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSats provides new spectrally resolved measurements from 0.8 -12 keV. The MinXSS spectral resolving power (R 40 at 5.9 keV) allows plasma abundances to be determined for Fe, Mg, Ni, Ca, Si, S, and Ar. Long-term temporal variations during quiet-Sun times allow active region contributions to be extracted from the full solar flux. The MinXSS 10 second time cadence allows short-term variations of the soft X-ray flux, temperature, and abundances to be determined during flares. The MinXSS spectroscopic observations, combined with the imaging spectroscopy from the Hinode X-ray Telescope (XRT) and the Reuven Ramaty Solar Spectroscopic Imager (RHESSI), hold great potential for advancing our understanding of solar dynamics.

  2. Lagrangian methods of cosmic web classification

    NASA Astrophysics Data System (ADS)

    Fisher, J. D.; Faltenbacher, A.; Johnson, M. S. T.

    2016-05-01

    The cosmic web defines the large-scale distribution of matter we see in the Universe today. Classifying the cosmic web into voids, sheets, filaments and nodes allows one to explore structure formation and the role environmental factors have on halo and galaxy properties. While existing studies of cosmic web classification concentrate on grid-based methods, this work explores a Lagrangian approach where the V-web algorithm proposed by Hoffman et al. is implemented with techniques borrowed from smoothed particle hydrodynamics. The Lagrangian approach allows one to classify individual objects (e.g. particles or haloes) based on properties of their nearest neighbours in an adaptive manner. It can be applied directly to a halo sample which dramatically reduces computational cost and potentially allows an application of this classification scheme to observed galaxy samples. Finally, the Lagrangian nature admits a straightforward inclusion of the Hubble flow negating the necessity of a visually defined threshold value which is commonly employed by grid-based classification methods.

  3. A Spitzer search for transits of radial velocity detected super-Earths

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kammer, J. A.; Knutson, H. A.; Desert, J.-M.

    2014-02-01

    Unlike hot Jupiters or other gas giants, super-Earths are expected to have a wide variety of compositions, ranging from terrestrial bodies like our own to more gaseous planets like Neptune. Observations of transiting systems, which allow us to directly measure planet masses and radii and constrain atmospheric properties, are key to understanding the compositional diversity of the planets in this mass range. Although Kepler has discovered hundreds of transiting super-Earth candidates over the past 4 yr, the majority of these planets orbit stars that are too far away and too faint to allow for detailed atmospheric characterization and reliable massmore » estimates. Ground-based transit surveys focus on much brighter stars, but most lack the sensitivity to detect planets in this size range. One way to get around the difficulty of finding these smaller planets in transit is to start by choosing targets that are already known to host super-Earth sized bodies detected using the radial velocity (RV) technique. Here we present results from a Spitzer program to observe six of the most favorable RV-detected super-Earth systems, including HD 1461, HD 7924, HD 156668, HIP 57274, and GJ 876. We find no evidence for transits in any of their 4.5 μm flux light curves, and place limits on the allowed transit depths and corresponding planet radii that rule out even the most dense and iron-rich compositions for these objects. We also observed HD 97658, but the observation window was based on a possible ground-based transit detection that was later ruled out; thus the window did not include the predicted time for the transit detection recently made by the Microvariability and Oscillations of Stars space telescope.« less

  4. Beam Spin Asymmetry Measurements for Two Pion Photoproduction at CLAS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anderson, Mark D.

    2015-09-01

    The overarching goal of this analysis, and many like it, is to develop our understanding of the strong force interactions within the nucleon by examining the nature of their excitation spectra. As the resonances of these spectra have very short lifetimes (tau = 1x10 -23 s) and often have very similar masses, it is often impossible to directly observe resonances in the excitation spectra of nucleons. Polarization observables allow us to study the resonances by looking at how they affect the spin state of final state particles. The beam asymmetry is a polarization observable that allows us to detect themore » sensitivity of these resonances, and other transition mechanisms, to the electric vector orientation of incident photons. Presented in this thesis are first measurements of the beam asymmetries in the resonant region for the reaction channel pgamma p --> p π + π -focusing on the intermediate mesonic states rho^0 and f^0, and the final state pions. The analysis used data from the g8b experiment undertaken at the Thomas Jefferson National Accelerator Facility (JLab), the first experiment at JLab to use a linearly polarized photon beam. Using the coherent Bremsstrahlung facility and the CLAS detector of Hall B at JLab allowed for many multi-channel reactions to be detected and the first measurements of many polarization observables including those presented here. A brief overview of the theoretical framework used to undertake this analysis is given, followed by a description of the experimental details of the facilities used, then a description of the calibration of the Bremsstrahlung tagging facility which the author undertook, and finally the analysis is presented and the resulting measurements.« less

  5. TRENTOOL: A Matlab open source toolbox to analyse information flow in time series data with transfer entropy

    PubMed Central

    2011-01-01

    Background Transfer entropy (TE) is a measure for the detection of directed interactions. Transfer entropy is an information theoretic implementation of Wiener's principle of observational causality. It offers an approach to the detection of neuronal interactions that is free of an explicit model of the interactions. Hence, it offers the power to analyze linear and nonlinear interactions alike. This allows for example the comprehensive analysis of directed interactions in neural networks at various levels of description. Here we present the open-source MATLAB toolbox TRENTOOL that allows the user to handle the considerable complexity of this measure and to validate the obtained results using non-parametrical statistical testing. We demonstrate the use of the toolbox and the performance of the algorithm on simulated data with nonlinear (quadratic) coupling and on local field potentials (LFP) recorded from the retina and the optic tectum of the turtle (Pseudemys scripta elegans) where a neuronal one-way connection is likely present. Results In simulated data TE detected information flow in the simulated direction reliably with false positives not exceeding the rates expected under the null hypothesis. In the LFP data we found directed interactions from the retina to the tectum, despite the complicated signal transformations between these stages. No false positive interactions in the reverse directions were detected. Conclusions TRENTOOL is an implementation of transfer entropy and mutual information analysis that aims to support the user in the application of this information theoretic measure. TRENTOOL is implemented as a MATLAB toolbox and available under an open source license (GPL v3). For the use with neural data TRENTOOL seamlessly integrates with the popular FieldTrip toolbox. PMID:22098775

  6. TRENTOOL: a Matlab open source toolbox to analyse information flow in time series data with transfer entropy.

    PubMed

    Lindner, Michael; Vicente, Raul; Priesemann, Viola; Wibral, Michael

    2011-11-18

    Transfer entropy (TE) is a measure for the detection of directed interactions. Transfer entropy is an information theoretic implementation of Wiener's principle of observational causality. It offers an approach to the detection of neuronal interactions that is free of an explicit model of the interactions. Hence, it offers the power to analyze linear and nonlinear interactions alike. This allows for example the comprehensive analysis of directed interactions in neural networks at various levels of description. Here we present the open-source MATLAB toolbox TRENTOOL that allows the user to handle the considerable complexity of this measure and to validate the obtained results using non-parametrical statistical testing. We demonstrate the use of the toolbox and the performance of the algorithm on simulated data with nonlinear (quadratic) coupling and on local field potentials (LFP) recorded from the retina and the optic tectum of the turtle (Pseudemys scripta elegans) where a neuronal one-way connection is likely present. In simulated data TE detected information flow in the simulated direction reliably with false positives not exceeding the rates expected under the null hypothesis. In the LFP data we found directed interactions from the retina to the tectum, despite the complicated signal transformations between these stages. No false positive interactions in the reverse directions were detected. TRENTOOL is an implementation of transfer entropy and mutual information analysis that aims to support the user in the application of this information theoretic measure. TRENTOOL is implemented as a MATLAB toolbox and available under an open source license (GPL v3). For the use with neural data TRENTOOL seamlessly integrates with the popular FieldTrip toolbox.

  7. Microscopic observation of carrier-transport dynamics in quantum-structure solar cells using a time-of-flight technique

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Toprasertpong, Kasidit; Fujii, Hiromasa; Sugiyama, Masakazu

    2015-07-27

    In this study, we propose a carrier time-of-flight technique to evaluate the carrier transport time across a quantum structure in an active region of solar cells. By observing the time-resolved photoluminescence signal with a quantum-well probe inserted under the quantum structure at forward bias, the carrier transport time can be efficiently determined at room temperature. The averaged drift velocity shows linear dependence on the internal field, allowing us to estimate the quantum structure as a quasi-bulk material with low effective mobility containing the information of carrier dynamics. We show that this direct and real-time observation is more sensitive to carriermore » transport than other conventional techniques, providing better insights into microscopic carrier transport dynamics to overcome a device design difficulty.« less

  8. Effects on the CMB from compactification before inflation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kontou, Eleni-Alexandra; Blanco-Pillado, Jose J.; Hertzberg, Mark P.

    2017-04-01

    Many theories beyond the Standard Model include extra dimensions, though these have yet to be directly observed. In this work we consider the possibility of a compactification mechanism which both allows extra dimensions and is compatible with current observations. This compactification is predicted to leave a signature on the CMB by altering the amplitude of the low l multipoles, dependent on the amount of inflation. Recently discovered CMB anomalies at low multipoles may be evidence for this. In our model we assume the spacetime is the product of a four-dimensional spacetime and flat extra dimensions. Before the compactification, both themore » four-dimensional spacetime and the extra dimensions can either be expanding or contracting independently. Taking into account physical constraints, we explore the observational consequences and the plausibility of these different models.« less

  9. Direct observation of the discrete energy spectrum of two lanthanide-based single-chain magnets by far-infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Haas, Sabrina; Heintze, Eric; Zapf, Sina; Gorshunov, Boris; Dressel, Martin; Bogani, Lapo

    2014-05-01

    The far-infrared optical transmission has been studied for two lanthanide-based single-chain magnets DyPhOPh and TbPhOPh in the frequency range between 3 and 80 cm-1. The spectra were acquired at temperatures between 2 and 80 K and magnetic fields up to 6 T. Based on their magnetic field dependence in DyPhOPh two of the observed absorption lines are identified as transitions inside the crystal field split Dy3+ ground multiplet 6H15/2, coupled to the neighboring spins. In TbPhOPh one transition was observed inside the crystal-field-split Tb3+ ground multiplet 7F6. The results allow a spectroscopic investigation of the role of single-ion anisotropy and exchange in Glauber dynamics.

  10. Sodium sulfate crystallisation monitoring using IR thermography

    NASA Astrophysics Data System (ADS)

    Vazquez, P.; Thomachot-Schneider, C.; Mouhoubi, K.; Bodnar, J.-L.; Avdelidis, N. P.; Charles, D.; Benavente, D.

    2018-03-01

    In this work, the evaporation of sodium sulfate droplets with different concentrations and at different temperatures were studied using infrared thermography (IRT). IRT allows to detect the evaporation evolution, the crystal growth and for the first time, to observe in vivo the heat release related to sodium sulfate crystallisation. A detailed study revealed that dendritic Thenardite III crystals appeared at the edge of all the crystallised droplets, though they showed a fast increase of temperature related to crystallisation only when a hydrated phase crystallised also from the droplet. The observation of the heat of crystallisation is thus directly related to the supersaturation of the droplet and consequently to temperature. In addition, IRT detection is circumscribed by the location of crystallisation. The heat can be observed and measured only when the crystallisation occurs in the interface solution - air.

  11. Charge collection microscopy of in-situ switchable PRAM line cells in a scanning electron microscope: Technique development and unique observations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oosthoek, J. L. M.; Schuitema, R. W.; Brink, G. H. ten

    2015-03-15

    An imaging method has been developed based on charge collection in a scanning electron microscope (SEM) that allows discrimination between the amorphous and crystalline states of Phase-change Random Access Memory (PRAM) line cells. During imaging, the cells are electrically connected and can be switched between the states and the resistance can be measured. This allows for electrical characterization of the line cells in-situ in the SEM. Details on sample and measurement system requirements are provided which turned out to be crucial for the successful development of this method. Results show that the amorphous or crystalline state of the line cellsmore » can be readily discerned, but the spatial resolution is relatively poor. Nevertheless, it is still possible to estimate the length of the amorphous mark, and also for the first time, we could directly observe the shift of the amorphous mark from one side of the line cell to the other side when the polarity of the applied (50 ns) RESET pulse was reversed.« less

  12. New tracking implementation in the Deep Space Network

    NASA Technical Reports Server (NTRS)

    Berner, Jeff B.; Bryant, Scott H.

    2001-01-01

    As part of the Network Simplification Project, the tracking system of the Deep Space Network is being upgraded. This upgrade replaces the discrete logic sequential ranging system with a system that is based on commercial Digital Signal Processor boards. The new implementation allows both sequential and pseudo-noise types of ranging. The other major change is a modernization of the data formatting. Previously, there were several types of interfaces, delivering both intermediate data and processed data (called 'observables'). All of these interfaces were bit-packed blocks, which do not allow for easy expansion, and many of these interfaces required knowledge of the specific hardware implementations. The new interface supports four classes of data: raw (direct from the measuring equipment), derived (the observable data), interferometric (multiple antenna measurements), and filtered (data whose values depend on multiple measurements). All of the measurements are reported at the sky frequency or phase level, so that no knowledge of the actual hardware is required. The data is formatted into Standard Formatted Data Units, as defined by the Consultative Committee for Space Data Systems, so that expansion and cross-center usage is greatly enhanced.

  13. Search for a Hypothetical 16.7 MeV Gauge Boson and Dark Photons in the NA64 Experiment at CERN

    NASA Astrophysics Data System (ADS)

    Banerjee, D.; Burtsev, V. E.; Chumakov, A. G.; Cooke, D.; Crivelli, P.; Depero, E.; Dermenev, A. V.; Donskov, S. V.; Dusaev, R. R.; Enik, T.; Charitonidis, N.; Feshchenko, A.; Frolov, V. N.; Gardikiotis, A.; Gerassimov, S. G.; Gninenko, S. N.; Hösgen, M.; Jeckel, M.; Karneyeu, A. E.; Kekelidze, G.; Ketzer, B.; Kirpichnikov, D. V.; Kirsanov, M. M.; Konorov, I. V.; Kovalenko, S. G.; Kramarenko, V. A.; Kravchuk, L. V.; Krasnikov, N. V.; Kuleshov, S. V.; Lyubovitskij, V. E.; Lysan, V.; Matveev, V. A.; Mikhailov, Yu. V.; Peshekhonov, D. V.; Polyakov, V. A.; Radics, B.; Rojas, R.; Rubbia, A.; Samoylenko, V. D.; Tikhomirov, V. O.; Tlisov, D. A.; Toropin, A. N.; Trifonov, A. Yu.; Vasilishin, B. I.; Vasquez Arenas, G.; Volkov, P. V.; Volkov, V.; Ulloa, P.; NA64 Collaboration

    2018-06-01

    We report the first results on a direct search for a new 16.7 MeV boson (X ) which could explain the anomalous excess of e+e- pairs observed in the excited Be* 8 nucleus decays. Because of its coupling to electrons, the X could be produced in the bremsstrahlung reaction e-Z →e-Z X by a 100 GeV e- beam incident on an active target in the NA64 experiment at the CERN Super Proton Synchrotron and observed through the subsequent decay into a e+e- pair. With 5.4 ×1010 electrons on target, no evidence for such decays was found, allowing us to set first limits on the X -e- coupling in the range 1.3 ×10-4≲ɛe≲4.2 ×10-4 excluding part of the allowed parameter space. We also set new bounds on the mixing strength of photons with dark photons (A') from nonobservation of the decay A'→e+e- of the bremsstrahlung A' with a mass ≲23 MeV .

  14. Design of an Experiment to Observe Laser-Plasma Interactions on NIKE

    NASA Astrophysics Data System (ADS)

    Phillips, L.; Weaver, J.; Manheimer, W.; Zalesak, S.; Schmitt, A.; Fyfe, D.; Afeyan, B.; Charbonneau-Lefort, M.

    2007-11-01

    Recent proposed designs (Obenschain et al., Phys. Plasmas 13 056320 (2006)) for direct-drive ICF targets for energy applications involve high implosion velocities combined with higher laser irradiances. The use of high irradiances increases the likelihood of deleterious laser plasma instabilities (LPI) that may lead, for example, to the generation of fast electrons. The proposed use of a 248 nm KrF laser to drive these targets is expected to minimize LPI; this is being studied by experiments at NRL's NIKE facility. We used a modification of the FAST code that models laser pulses with arbitrary spatial and temporal profiles to assist in designing these experiments. The goal is to design targets and pulseshapes to create plasma conditions that will produce sufficient growth of LPI to be observable on NIKE. Using, for example, a cryogenic DT target that is heated by a brief pulse and allowed to expand freely before interacting with a second, high-intensity pulse, allows the development of long scalelengths at low electron temperatures and leads to a predicted 20-efold growth in two-plasmon amplitude.

  15. Correlation of ICME Magnetic Fields at Radially Aligned Spacecraft

    NASA Astrophysics Data System (ADS)

    Good, S. W.; Forsyth, R. J.; Eastwood, J. P.; Möstl, C.

    2018-03-01

    The magnetic field structures of two interplanetary coronal mass ejections (ICMEs), each observed by a pair of spacecraft close to radial alignment, have been analysed. The ICMEs were observed in situ by MESSENGER and STEREO-B in November 2010 and November 2011, while the spacecraft were separated by more than 0.6 AU in heliocentric distance, less than 4° in heliographic longitude, and less than 7° in heliographic latitude. Both ICMEs took approximately two days to travel between the spacecraft. The ICME magnetic field profiles observed at MESSENGER have been mapped to the heliocentric distance of STEREO-B and compared directly to the profiles observed by STEREO-B. Figures that result from this mapping allow for easy qualitative assessment of similarity in the profiles. Macroscale features in the profiles that varied on timescales of one hour, and which corresponded to the underlying flux rope structure of the ICMEs, were well correlated in the solar east-west and north-south directed components, with Pearson's correlation coefficients of approximately 0.85 and 0.95, respectively; microscale features with timescales of one minute were uncorrelated. Overall correlation values in the profiles of one ICME were increased when an apparent change in the flux rope axis direction between the observing spacecraft was taken into account. The high degree of similarity seen in the magnetic field profiles may be interpreted in two ways. If the spacecraft sampled the same region of each ICME ( i.e. if the spacecraft angular separations are neglected), the similarity indicates that there was little evolution in the underlying structure of the sampled region during propagation. Alternatively, if the spacecraft observed different, nearby regions within the ICMEs, it indicates that there was spatial homogeneity across those different regions. The field structure similarity observed in these ICMEs points to the value of placing in situ space weather monitors well upstream of the Earth.

  16. DISTINGUISHING COMPACT BINARY POPULATION SYNTHESIS MODELS USING GRAVITATIONAL WAVE OBSERVATIONS OF COALESCING BINARY BLACK HOLES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stevenson, Simon; Ohme, Frank; Fairhurst, Stephen, E-mail: simon.stevenson@ligo.org

    2015-09-01

    The coalescence of compact binaries containing neutron stars or black holes is one of the most promising signals for advanced ground-based laser interferometer gravitational-wave (GW) detectors, with the first direct detections expected over the next few years. The rate of binary coalescences and the distribution of component masses is highly uncertain, and population synthesis models predict a wide range of plausible values. Poorly constrained parameters in population synthesis models correspond to poorly understood astrophysics at various stages in the evolution of massive binary stars, the progenitors of binary neutron star and binary black hole systems. These include effects such asmore » supernova kick velocities, parameters governing the energetics of common envelope evolution and the strength of stellar winds. Observing multiple binary black hole systems through GWs will allow us to infer details of the astrophysical mechanisms that lead to their formation. Here we simulate GW observations from a series of population synthesis models including the effects of known selection biases, measurement errors and cosmology. We compare the predictions arising from different models and show that we will be able to distinguish between them with observations (or the lack of them) from the early runs of the advanced LIGO and Virgo detectors. This will allow us to narrow down the large parameter space for binary evolution models.« less

  17. Simulating the universe(s) II: phenomenology of cosmic bubble collisions in full general relativity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wainwright, Carroll L.; Aguirre, Anthony; Johnson, Matthew C.

    2014-10-01

    Observing the relics of collisions between bubble universes would provide direct evidence for the existence of an eternally inflating Multiverse; the non-observation of such events can also provide important constraints on inflationary physics. Realizing these prospects requires quantitative predictions for observables from the properties of the possible scalar field Lagrangians underlying eternal inflation. Building on previous work, we establish this connection in detail. We perform a fully relativistic numerical study of the phenomenology of bubble collisions in models with a single scalar field, computing the comoving curvature perturbation produced in a wide variety of models. We also construct a setmore » of analytic predictions, allowing us to identify the phenomenologically relevant properties of the scalar field Lagrangian. The agreement between the analytic predictions and numerics in the relevant regions is excellent, and allows us to generalize our results beyond the models we adopt for the numerical studies. Specifically, the signature is completely determined by the spatial profile of the colliding bubble just before the collision, and the de Sitter invariant distance between the bubble centers. The analytic and numerical results support a power-law fit with an index 1< κ ∼< 2. For collisions between identical bubbles, we establish a lower-bound on the observed amplitude of collisions that is set by the present energy density in curvature.« less

  18. A data model for environmental scientists

    NASA Astrophysics Data System (ADS)

    Kapeljushnik, O.; Beran, B.; Valentine, D.; van Ingen, C.; Zaslavsky, I.; Whitenack, T.

    2008-12-01

    Environmental science encompasses a wide range of disciplines from water chemistry to microbiology, ecology and atmospheric sciences. Studies often require working across disciplines which differ in their ways of describing and storing data such that it is not possible to devise a monolithic one-size-fits-all data solution. Based on our experiences with Consortium of the Universities for the Advancement of Hydrologic Science Inc. (CUAHSI) Observations Data Model, Berkeley Water Center FLUXNET carbon-climate work and by examining standards like EPA's Water Quality Exchange (WQX), we have developed a flexible data model that allows extensions without need to altering the schema such that scientists can define custom metadata elements to describe their data including observations, analysis methods as well as sensors and geographical features. The data model supports various types of observations including fixed point and moving sensors, bottled samples, rasters from remote sensors and models, and categorical descriptions (e.g. taxonomy) by employing user-defined-types when necessary. It leverages ADO .NET Entity Framework to provide the semantic data models for differing disciplines, while maintaining a common schema below the entity layer. This abstraction layer simplifies data retrieval and manipulation by hiding the logic and complexity of the relational schema from users thus allows programmers and scientists to deal directly with objects such as observations, sensors, watersheds, river reaches, channel cross-sections, laboratory analysis methods and samples as opposed to table joins, columns and rows.

  19. Grs 1915+105: a superluminal source in the Galaxy.

    PubMed Central

    Rodríguez, L F; Mirabel, I F

    1995-01-01

    We present the results of additional observations of the high energy source GRS 1915+105, which produces ejecta with apparent superluminal motions. The observations reported here were carried out with the Very Large Array at 3.5 cm and 20 cm. The 3.5-cm observations made during 1994 May allowed us to continue following the proper motions of the bright 1994 March 19 ejecta, as well as those of a subsequent, fainter ejection. The proper motions of the 1994 March 19 ejecta continued to be ballistic (i.e., constant) over the period of about 75 days where they remained detectable. From the observations in 1994 March-May we have identified three ejections of pairs of plasma clouds moving ballistically in approximately the same direction on the sky with similar proper motions. The 20-cm observations made during 1994 November and December were used to search, yet unsuccessfully, for extended jets or lobes associated with GRS 1915+105. PMID:11607605

  20. Responses to the advanced notice of proposed rulemaking EPA published on June 6, 1996 regarding changes to the EPA allowance auctions and elimination of the direct sale

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Critchfield, L.R.

    1997-12-31

    On June 6, 1996, EPA`s Acid Rain Program published an advance notice of proposed rulemaking (ANPRM) in the Federal Register seeking comment on: (1) whether to change the design of the annual sulfur dioxide (SO{sub 2}) allowance auctions; (2) whether to change the timing of the allowance auctions; (3) whether to change the requirement that the minimum price of offered allowances must be in whole dollars, and (4) whether EPA should propose the ability to submit allowance transfers electronically. EPA also published on that day a proposed and direct final rule on whether to eliminate the direct sale. This papermore » documents the issues addressed in the ANPRM, the comments EPA received, and EPA`s responses to those comments. EPA received comments from 14 separate commenters.« less

  1. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fernandes, P. A.; Lynch, K. A.

    Here, we define the observational parameter regime necessary for observing low-altitude ionospheric origins of high-latitude ion upflow/outflow. We present measurement challenges and identify a new analysis technique which mitigates these impediments. To probe the initiation of auroral ion upflow, it is necessary to examine the thermal ion population at 200-350 km, where typical thermal energies are tenths of eV. Interpretation of the thermal ion distribution function measurement requires removal of payload sheath and ram effects. We use a 3-D Maxwellian model to quantify how observed ionospheric parameters such as density, temperature, and flows affect in situ measurements of the thermalmore » ion distribution function. We define the viable acceptance window of a typical top-hat electrostatic analyzer in this regime and show that the instrument's energy resolution prohibits it from directly observing the shape of the particle spectra. To extract detailed information about measured particle population, we define two intermediate parameters from the measured distribution function, then use a Maxwellian model to replicate possible measured parameters for comparison to the data. Liouville's theorem and the thin-sheath approximation allow us to couple the measured and modeled intermediate parameters such that measurements inside the sheath provide information about plasma outside the sheath. We apply this technique to sounding rocket data to show that careful windowing of the data and Maxwellian models allows for extraction of the best choice of geophysical parameters. More widespread use of this analysis technique will help our community expand its observational database of the seed regions of ionospheric outflows.« less

  2. Large-Scale Reactive Atomistic Simulation of Shock-induced Initiation Processes in Energetic Materials

    NASA Astrophysics Data System (ADS)

    Thompson, Aidan

    2013-06-01

    Initiation in energetic materials is fundamentally dependent on the interaction between a host of complex chemical and mechanical processes, occurring on scales ranging from intramolecular vibrations through molecular crystal plasticity up to hydrodynamic phenomena at the mesoscale. A variety of methods (e.g. quantum electronic structure methods (QM), non-reactive classical molecular dynamics (MD), mesoscopic continuum mechanics) exist to study processes occurring on each of these scales in isolation, but cannot describe how these processes interact with each other. In contrast, the ReaxFF reactive force field, implemented in the LAMMPS parallel MD code, allows us to routinely perform multimillion-atom reactive MD simulations of shock-induced initiation in a variety of energetic materials. This is done either by explicitly driving a shock-wave through the structure (NEMD) or by imposing thermodynamic constraints on the collective dynamics of the simulation cell e.g. using the Multiscale Shock Technique (MSST). These MD simulations allow us to directly observe how energy is transferred from the shockwave into other processes, including intramolecular vibrational modes, plastic deformation of the crystal, and hydrodynamic jetting at interfaces. These processes in turn cause thermal excitation of chemical bonds leading to initial chemical reactions, and ultimately to exothermic formation of product species. Results will be presented on the application of this approach to several important energetic materials, including pentaerythritol tetranitrate (PETN) and ammonium nitrate/fuel oil (ANFO). In both cases, we validate the ReaxFF parameterizations against QM and experimental data. For PETN, we observe initiation occurring via different chemical pathways, depending on the shock direction. For PETN containing spherical voids, we observe enhanced sensitivity due to jetting, void collapse, and hotspot formation, with sensitivity increasing with void size. For ANFO, we examine the effect of reaction rates on shock direction, fuel oil fraction, and crystal/fuel oil/void microstructural arrangement. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Dept. of Energy's National Nuclear Security Admin. under contract DEAC0494AL85000.

  3. Note on the directional properties of meter-scale gravity waves

    NASA Astrophysics Data System (ADS)

    Peureux, Charles; Benetazzo, Alvise; Ardhuin, Fabrice

    2018-01-01

    The directional distribution of the energy of young waves is bimodal for frequencies above twice the peak frequency; i.e., their directional distribution exhibits two peaks in different directions and a minimum between. Here we analyze in detail a typical case measured with a peak frequency fp = 0.18 Hz and a wind speed of 10.7 m s-1 using a stereo-video system. This technique allows for the separation of free waves from the spectrum of the sea-surface elevation. The latter indeed tend to reduce the contrast between the two peaks and the background. The directional distribution for a given wavenumber is nearly symmetric, with the angle distance between the two peaks growing with frequency, reaching 150° at 35 times the peak wavenumber kp and increasing up to 45 kp. When considering only free waves, the lobe ratio, the ratio of oblique peak energy density over energy in the wind direction, increases linearly with the non-dimensional wavenumber k/kp, up to a value of 6 at k/kp 22, and possibly more for shorter components. These observations extend to shorter components' previous measurements, and have important consequences for wave properties sensitive to the directional distribution, such as surface slopes, Stokes drift or microseism sources.

  4. Direct photoassociation of halo molecules in ultracold 86 Sr

    NASA Astrophysics Data System (ADS)

    Aman, J. A.; Hill, Joshua; Killian, T. C.

    2017-04-01

    We investigate the creation of 1S0 +1S0 halo molecules in strontium 86 through direct photoassociation in an optical dipole trap. We drive two photon Raman transitions near-resonance with a molecular level of the 1S0 +3P1 interatomic potential as the intermediate state. This provides large Frank-Condon factors and allows us to observe resonances for the creation of halo molecules through higher order Raman processes. The halo molecule is bound by EB 85 kHz at low excitation-laser intensity, but experiments show large AC Stark shifts of the molecular binding energy. These conditions suggest that STIRAP should be very effective for improving molecular conversion efficiency. Further experiments in a 3D lattice will explore molecular lifetimes and collision rates. Travel support provided by Shell Corporation.

  5. Integrated microelectromechanical gyroscope under shock loads

    NASA Astrophysics Data System (ADS)

    Nesterenko, T. G.; Koleda, A. N.; Barbin, E. S.

    2018-01-01

    The paper presents a new design of a shock-proof two-axis microelectromechanical gyroscope. Without stoppers, the shock load enables the interaction between the silicon sensor elements. Stoppers were installed in the gyroscope to prevent the contact interaction between electrodes and spring elements with fixed part of the sensor. The contact of stoppers occurs along the plane, thereby preventing the system from serious contact stresses. The shock resistance of the gyroscope is improved by the increase in its eigenfrequency at which the contact interaction does not occur. It is shown that the shock load directed along one axis does not virtually cause the movement of sensing elements along the crosswise axes. Maximum stresses observed in the proposed gyroscope at any loading direction do not exceed the value allowable for silicon.

  6. SCANNING VOLTA POTENTIALS MEASUREMENTS OF METALS IN IRRADIATED AIR.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    ISAACS, H.S.; ADZIC, G.; AND ENERGY SCIENCES AND TECHNOLOGY DEPARTMENT

    2000-10-22

    A method for direct dc measurement of the Volta potential is presented. High intensity synchrotron x-ray beams were used to locally irradiate the atmosphere adjacent to the metal surface and produce a conducting path between a sample and a reference probe. The direct measurements of potential in the ionized air could be made at probe heights of around 1 mm compared to less than 0.1 mm for the Kelvin probe. The measurements were similar to traditional Kelvin probe measurements, but had a poorer spatial resolution. In contrast to the Kelvin probe methods, the approach described allows observation of the currentmore » as a function of impressed voltage. Methods to improve the special resolution of the technique and applications to corrosion under coating will be presented.« less

  7. Direct Observation of Insulin Association Dynamics with Time-Resolved X-ray Scattering

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rimmerman, Dolev; Leshchev, Denis; Hsu, Darren J.

    Biological functions frequently require protein-protein interactions that involve secondary and tertiary structural perturbation. Here we study protein-protein dissociation and reassociation dynamics in insulin, a model system for protein oligomerization. Insulin dimer dissociation into monomers was induced by a nanosecond temperature-jump (T-jump) of ~8 °C in aqueous solution, and the resulting protein and solvent dynamics were tracked by time-resolved X-ray solution scattering (TRXSS) on time scales of 10 ns to 100 ms. The protein scattering signals revealed the formation of five distinguishable transient species during the association process that deviate from simple two state kinetics. Our results show that the combinationmore » of T-jump pump coupled to TRXSS probe allows for direct tracking of structural dynamics in nonphotoactive proteins.« less

  8. Droplet distributions from melt displacement and ejection mechanism during Al ns-laser ablation and deposition experiments: Influence of laser spot position

    NASA Astrophysics Data System (ADS)

    Cultrera, L.; Lorusso, A.; Maiolo, B.; Cangueiro, L.; Vilar, R.; Perrone, A.

    2014-03-01

    Experimental observations of the angular distribution of droplets during laser ablation and deposition of Al thin films are presented and discussed. The experimental results, obtained by simply moving the laser spot position with respect to the rotation axis of the target, allow clarification of the unexpected symmetric double peaked angular droplet distribution on the films. These results provide direct evidence that a laser fluence threshold exists, beyond which droplets are generated from a melt displacement and ejection mechanism rather than from a phase explosion. The main directions of particulate ejection are related to the particular geometry of the laser generated tracks, whose profiles depend on the relative position of the incident beam with respect to the rotation axis of the target.

  9. Ultrashort pulse chirp measurement via transverse second-harmonic generation in strontium barium niobate crystal

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Trull, J.; Wang, B.; Parra, A.

    2015-06-01

    Pulse compression in dispersive strontium barium niobate crystal with a random size and distribution of the anti-parallel orientated nonlinear domains is observed via transverse second harmonic generation. The dependence of the transverse width of the second harmonic trace along the propagation direction allows for the determination of the initial chirp and duration of pulses in the femtosecond regime. This technique permits a real-time analysis of the pulse evolution and facilitates fast in-situ correction of pulse chirp acquired in the propagation through an optical system.

  10. Closed timelike curves produced by pairs of moving cosmic strings - Exact solutions

    NASA Technical Reports Server (NTRS)

    Gott, J. Richard, III

    1991-01-01

    Exact solutions of Einstein's field equations are presented for the general case of two moving straight cosmic strings that do not intersect. The solutions for parallel cosmic strings moving in opposite directions show closed timelike curves (CTCs) that circle the two strings as they pass, allowing observers to visit their own past. Similar results occur for nonparallel strings, and for masses in (2+1)-dimensional spacetime. For finite string loops the possibility that black-hole formation may prevent the formation of CTCs is discussed.

  11. A density distribution algorithm for bone incorporating local orthotropy, modal analysis and theories of cellular solids.

    PubMed

    Impelluso, Thomas J

    2003-06-01

    An algorithm for bone remodeling is presented which allows for both a redistribution of density and a continuous change of principal material directions for the orthotropic material properties of bone. It employs a modal analysis to add density for growth and a local effective strain based analysis to redistribute density. General re-distribution functions are presented. The model utilizes theories of cellular solids to relate density and strength. The code predicts the same general density distributions and local orthotropy as observed in reality.

  12. Real space mapping of Li-ion transport in amorphous Si anodes with nanometer resolution.

    PubMed

    Balke, Nina; Jesse, Stephen; Kim, Yoongu; Adamczyk, Leslie; Tselev, Alexander; Ivanov, Ilia N; Dudney, Nancy J; Kalinin, Sergei V

    2010-09-08

    The electrical bias driven Li-ion motion in silicon anode materials in thin film battery heterostructures is investigated using electrochemical strain microscopy (ESM), which is a newly developed scanning probe microscopy based characterization method. ESM utilizes the intrinsic link between bias-controlled Li-ion concentration and molar volume of electrode materials, providing the capability for studies on the sub-20 nm scale, and allows the relationship between Li-ion flow and microstructure to be established. The evolution of Li-ion transport during the battery charging is directly observed.

  13. Direct mapping of ion diffusion times on LiCoO2 surfaces with nanometer resolution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guo, Senli; Jesse, Stephen; Kalnaus, Sergiy

    2011-01-01

    The strong coupling between the molar volume and mobile ion concentration in ionically-conductive solids is used for spatially-resolved studies of ionic transport on the polycrystalline LiCoO2 surface by time-resolved spectroscopy. Strong variability between ionic transport at the grain boundaries and within the grains is observed, and the relationship between relaxation and hysteresis loop formation is established. The use of the strain measurements allows ionic transport be probed on the nanoscale, and suggests enormous potential for probing ionic materials and devices.

  14. A Local Probe for Universal Non-equilibrium Dynamics

    DTIC Science & Technology

    2015-06-01

    left in the ground 1T. E. Drake, Y . Sagi, R. Paudel, J. T. Stewart, J. P . Gaebler, and D. S. Jin, “ Direct observation of the fermi surface in an...bottom) allow to switch the laser fast and fine-tune the frequency. “λ/2” refers to half-wave plates, “λ/4” refers to quarter-wave plates, and all cubes...the beat note signal on a fast photodiode. state (|F = 9/2,mF = −7/2〉), any place where excitation light exists. Imaging atoms occurs on a cycling

  15. Note: A quartz cell with Pt single crystal bead electrode for electrochemical scanning tunneling microscope measurements.

    PubMed

    Xia, Zhigang; Wang, Jihao; Hou, Yubin; Lu, Qingyou

    2014-09-01

    In this paper, we provide and demonstrate a design of a unique cell with Pt single crystal bead electrode for electrochemical scanning tunneling microscope (ECSTM) measurements. The active metal Pt electrode can be protected from air contamination during the preparation process. The transparency of the cell allows the tip and bead to be aligned by direct observation. Based on this, a new and effective alignment method is introduced. The high-quality bead preparations through this new cell have been confirmed by the ECSTM images of Pt (111).

  16. Torus Breakdown and Homoclinic Chaos in a Glow Discharge Tube

    NASA Astrophysics Data System (ADS)

    Ginoux, Jean-Marc; Meucci, Riccardo; Euzzor, Stefano

    2017-12-01

    Starting from historical researches, we used, like Van der Pol and Le Corbeiller, a cubic function for modeling the current-voltage characteristic of a direct current low-pressure plasma discharge tube, i.e. a neon tube. This led us to propose a new four-dimensional autonomous dynamical system allowing to describe the experimentally observed phenomenon. Then, mathematical analysis and detailed numerical investigations of such a fourth-order torus circuit enabled to highlight bifurcation routes from torus breakdown to homoclinic chaos following the Newhouse-Ruelle-Takens scenario.

  17. Multiple-Star System Adaptive Vortex Coronagraphy Using a Liquid Crystal Light Valve

    NASA Astrophysics Data System (ADS)

    Aleksanyan, Artur; Kravets, Nina; Brasselet, Etienne

    2017-05-01

    We propose the development of a high-contrast imaging technique enabling the simultaneous and selective nulling of several light sources. This is done by realizing a reconfigurable multiple-vortex phase mask made of a liquid crystal thin film on which local topological features can be addressed electro-optically. The method is illustrated by reporting on a triple-star optical vortex coronagraphy laboratory demonstration, which can be easily extended to higher multiplicity. These results allow considering the direct observation and analysis of worlds with multiple suns and more complex extrasolar planetary systems.

  18. New error calibration tests for gravity models using subset solutions and independent data - Applied to GEM-T3

    NASA Technical Reports Server (NTRS)

    Lerch, F. J.; Nerem, R. S.; Chinn, D. S.; Chan, J. C.; Patel, G. B.; Klosko, S. M.

    1993-01-01

    A new method has been developed to provide a direct test of the error calibrations of gravity models based on actual satellite observations. The basic approach projects the error estimates of the gravity model parameters onto satellite observations, and the results of these projections are then compared with data residual computed from the orbital fits. To allow specific testing of the gravity error calibrations, subset solutions are computed based on the data set and data weighting of the gravity model. The approach is demonstrated using GEM-T3 to show that the gravity error estimates are well calibrated and that reliable predictions of orbit accuracies can be achieved for independent orbits.

  19. Radiation Channels Close to a Plasmonic Nanowire Visualized by Back Focal Plane Imaging

    PubMed Central

    Hartmann, Nicolai; Piatkowski, Dawid; Ciesielski, Richard; Mackowski, Sebastian; Hartschuh, Achim

    2014-01-01

    We investigated the angular radiation patterns, a key characteristic of an emitting system, from individual silver nanowires decorated with rare earth ion-doped nanocrystals. Back focal plane radiation patterns of the nanocrystal photoluminescence after local two-photon excitation can be described by two emission channels: Excitation of propagating surface plasmons in the nanowire followed by leakage radiation and direct dipolar emission observed also in the absence of the nanowire. Theoretical modeling reproduces the observed radiation patterns which strongly depend on the position of excitation along the nanowire. Our analysis allows to estimate the branching ratio into both emission channels and to determine the diameter dependent surface plasmon quasi-momentum, important parameters of emitter-plasmon structures. PMID:24131299

  20. The Resolvent Algebra of Non-relativistic Bose Fields: Observables, Dynamics and States

    NASA Astrophysics Data System (ADS)

    Buchholz, Detlev

    2018-05-01

    The structure of the gauge invariant (particle number preserving) C*-algebra generated by the resolvents of a non-relativistic Bose field is analyzed. It is shown to form a dense subalgebra of the bounded inverse limit of a directed system of approximately finite dimensional C*-algebras. Based on this observation, it is proven that the closure of the gauge invariant algebra is stable under the dynamics induced by Hamiltonians involving pair potentials. These facts allow to proceed to a description of interacting Bosons in terms of C*-dynamical systems. It is outlined how the present approach leads to simplifications in the construction of infinite bosonic states and sheds new light on topics in many body theory.

  1. Acoustic solitons in waveguides with Helmholtz resonators: transmission line approach.

    PubMed

    Achilleos, V; Richoux, O; Theocharis, G; Frantzeskakis, D J

    2015-02-01

    We report experimental results and study theoretically soliton formation and propagation in an air-filled acoustic waveguide side loaded with Helmholtz resonators. We propose a theoretical modeling of the system, which relies on a transmission-line approach, leading to a nonlinear dynamical lattice model. The latter allows for an analytical description of the various soliton solutions for the pressure, which are found by means of dynamical systems and multiscale expansion techniques. These solutions include Boussinesq-like and Korteweg-de Vries pulse-shaped solitons that are observed in the experiment, as well as nonlinear Schrödinger envelope solitons, that are predicted theoretically. The analytical predictions are in excellent agreement with direct numerical simulations and in qualitative agreement with the experimental observations.

  2. Spatial variation in carrier dynamics along a single CdSSe nanowire

    NASA Astrophysics Data System (ADS)

    Blake, Jolie C.; Eldridge, Peter S.; Gundlach, Lars

    2014-10-01

    Ultrafast charge carrier dynamics along individual CdSxSe1-x nanowires has been measured. The use of an improved ultrafast Kerr-gated microscope allows for spatially resolved luminescence measurements along a single nanowire. Amplified spontaneous emission (ASE) was observed at high excitation fluences. Position dependent variations of ultrafast ASE dynamics were observed. SEM and colorimetric measurements showed that the difference in dynamics can be attributed to variations in non-radiative recombination rates along the wire. The dominant Shockley-Read recombination rate can be extracted from ASE dynamics and can be directly related to charge carrier mobility and defect density. Employing ASE as a probe for defect densities provides a new sub-micron spatially resolved, contactless method for measurements of charge carrier mobility.

  3. One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy

    PubMed Central

    Casini, Arturo; MacDonald, James T.; Jonghe, Joachim De; Christodoulou, Georgia; Freemont, Paul S.; Baldwin, Geoff S.; Ellis, Tom

    2014-01-01

    Overlap-directed DNA assembly methods allow multiple DNA parts to be assembled together in one reaction. These methods, which rely on sequence homology between the ends of DNA parts, have become widely adopted in synthetic biology, despite being incompatible with a key principle of engineering: modularity. To answer this, we present MODAL: a Modular Overlap-Directed Assembly with Linkers strategy that brings modularity to overlap-directed methods, allowing assembly of an initial set of DNA parts into a variety of arrangements in one-pot reactions. MODAL is accompanied by a custom software tool that designs overlap linkers to guide assembly, allowing parts to be assembled in any specified order and orientation. The in silico design of synthetic orthogonal overlapping junctions allows for much greater efficiency in DNA assembly for a variety of different methods compared with using non-designed sequence. In tests with three different assembly technologies, the MODAL strategy gives assembly of both yeast and bacterial plasmids, composed of up to five DNA parts in the kilobase range with efficiencies of between 75 and 100%. It also seamlessly allows mutagenesis to be performed on any specified DNA parts during the process, allowing the one-step creation of construct libraries valuable for synthetic biology applications. PMID:24153110

  4. Rapid Neutrino Cooling in the Neutron Star MXB 1659-29.

    PubMed

    Brown, Edward F; Cumming, Andrew; Fattoyev, Farrukh J; Horowitz, C J; Page, Dany; Reddy, Sanjay

    2018-05-04

    We show that the neutron star in the transient system MXB 1659-29 has a core neutrino luminosity that substantially exceeds that of the modified Urca reactions (i.e., n+n→n+p+e^{-}+ν[over ¯]_{e} and inverse) and is consistent with the direct Urca (n→p+e^{-}+ν[over ¯]_{e} and inverse) reaction occurring in a small fraction of the core. Observations of the thermal relaxation of the neutron star crust following 2.5 yr of accretion allow us to measure the energy deposited into the core during accretion, which is then reradiated as neutrinos, and infer the core temperature. For a nucleonic core, this requires that the nucleons are unpaired and that the proton fraction exceeds a critical value to allow the direct Urca reaction to proceed. The neutron star in MXB 1659-29 is the first with a firmly detected thermal component in its x-ray spectrum that needs a fast neutrino-cooling process. Measurements of the temperature variation of the neutron star core during quiescence would place an upper limit on the core specific heat and serve as a check on the fraction of the neutron star core in which nucleons are unpaired.

  5. Rapid Neutrino Cooling in the Neutron Star MXB 1659-29

    NASA Astrophysics Data System (ADS)

    Brown, Edward F.; Cumming, Andrew; Fattoyev, Farrukh J.; Horowitz, C. J.; Page, Dany; Reddy, Sanjay

    2018-05-01

    We show that the neutron star in the transient system MXB 1659-29 has a core neutrino luminosity that substantially exceeds that of the modified Urca reactions (i.e., n +n →n +p +e-+ν¯ e and inverse) and is consistent with the direct Urca (n →p +e-+ν¯e and inverse) reaction occurring in a small fraction of the core. Observations of the thermal relaxation of the neutron star crust following 2.5 yr of accretion allow us to measure the energy deposited into the core during accretion, which is then reradiated as neutrinos, and infer the core temperature. For a nucleonic core, this requires that the nucleons are unpaired and that the proton fraction exceeds a critical value to allow the direct Urca reaction to proceed. The neutron star in MXB 1659-29 is the first with a firmly detected thermal component in its x-ray spectrum that needs a fast neutrino-cooling process. Measurements of the temperature variation of the neutron star core during quiescence would place an upper limit on the core specific heat and serve as a check on the fraction of the neutron star core in which nucleons are unpaired.

  6. A new effective assay to detect antimicrobial activity of filamentous fungi.

    PubMed

    Pereira, Eric; Santos, Ana; Reis, Francisca; Tavares, Rui M; Baptista, Paula; Lino-Neto, Teresa; Almeida-Aguiar, Cristina

    2013-01-15

    The search for new antimicrobial compounds and the optimization of production methods turn the use of antimicrobial susceptibility tests a routine. The most frequently used methods are based on agar diffusion assays or on dilution in agar or broth. For filamentous fungi, the most common antimicrobial activity detection methods comprise the co-culture of two filamentous fungal strains or the use of fungal extracts to test against single-cell microorganisms. Here we report a rapid, effective and reproducible assay to detect fungal antimicrobial activity against single-cell microorganisms. This method allows an easy way of performing a fast antimicrobial screening of actively growing fungi directly against yeast. Because it makes use of an actively growing mycelium, this bioassay also provides a way for studying the production dynamics of antimicrobial compounds by filamentous fungi. The proposed assay is less time consuming and introduces the innovation of allowing the direct detection of fungal antimicrobial properties against single cell microorganisms without the prior isolation of the active substance(s). This is particularly useful when performing large screenings for fungal antimicrobial activity. With this bioassay, antimicrobial activity of Hypholoma fasciculare against yeast species was observed for the first time. Copyright © 2012 Elsevier GmbH. All rights reserved.

  7. A Worldwide Glacier Information System to go

    NASA Astrophysics Data System (ADS)

    Mölg, N.; Steinmann, M.; Zemp, M.

    2016-12-01

    In the forefront of the Paris Climate Conference COP21 in December 2015, the WGMS and UNESCO jointly launched a glacier application for mobile devices. This new information system aims at bringing scientifically sound facts and figures on worldwide glacier changes to decision makers at governmental and intergovernmental levels as well as reaching out to the interested public. The wgms Glacier App provides a map interface based on satellite images that display all the observed glaciers in the user's proximity. Basic information is provided for each glacier, including photographs and general information on size and elevation. Graphs with observation data illustrate the glacier's development, along with information on latest principal investigators and their sponsoring agencies as well as detailed explanations of the measurement types. A text search allows the user to filter the glacier by name, country, region, measurement type and the current "health" status, i.e. if the glacier has gained or lost ice over the past decade. A compass shows the closest observed glaciers in all directions from the user's current position. Finally, the card game allows the user to compete against the computer on the best monitored glaciers in the world. Our poster provides a visual entrance point to the wgms Glacier App and, hence, provides access to fluctuation series of more than 3'700 glaciers around the world.

  8. Determining the Full Halo Coronal Mass Ejection Characteristics

    NASA Astrophysics Data System (ADS)

    Fainshtein, V. G.

    2010-11-01

    Observing halo coronal mass ejections (HCMEs) in the coronagraph field of view allows one to only determine the apparent parameters in the plane of the sky. Recently, several methods have been proposed allowing one to find some true geometrical and kinematical parameters of HCMEs. In most cases, a simple cone model was used to describe the CME shape. Observations show that various modifications of the cone model ("ice cream models") are most appropriate for describing the shapes of individual CMEs. This paper uses the method of determining full HCME parameters proposed by the author earlier, for determining the parameters of 45 full HCMEs, with various modifications of their shapes. I show that the determined CME characteristics depend significantly on the chosen CME shape. I conclude that the absence of criteria for a preliminary evaluation of the CME shape is a major source of error in determining the true parameters of a full HCME with any of the known methods. I show that, regardless of the chosen CME form, the trajectory of practically all the HCMEs in question deviate from the radial direction towards the Sun-Earth axis at the initial stage of their movement, and their angular size, on average, significantly exceeds that of all the observable CMEs.

  9. Carbon Dioxide Convection in the Martian Polar Night and Its Implications for Polar Processes

    NASA Technical Reports Server (NTRS)

    Colaprete, A.; Haberle, R. M.

    2003-01-01

    Each Martian year nearly 30% of the atmosphere is exchanged with the polar ice caps. This exchange occurs through a combination of direct surface condensation and atmospheric precipitation of carbon dioxide. It has long been thought the amount of condensation within the polar night is maintained by a balance between diabatic processes such as radiative cooling and latent heating from condensing CO2. This assumption manifests itself in Mars General Circulation Models (GCM) in such a way as to never allow the atmospheric temperature to dip below the saturation temperature of CO2. However, observations from Mars Global Surveyor (MGS) Radio Science (RS) and the Thermal Emission Spectrometer (TES) have demonstrated this assumption to be, at best, approximate. Both RS and TES observations within the polar nights of both poles indicate substantial supersaturated regions with respect to CO2. The observed temperature profiles suggest conditionally unstable regions containing planetary significant amounts of potential convective energy. Presented here are estimates of the total planetary inventory of convective available potential energy (CAPE) and the potential convective energy flux (PCEF). The values for CAPE and PCEF are derived from RS temperature profiles and compared to Mars GCM results using a new convective CO2 cloud model that allows for the formation of CAPE.

  10. An ALMA Survey of Planet Forming Disks in Rho Ophiuchus

    NASA Astrophysics Data System (ADS)

    Cox, Erin Guilfoil; Looney, Leslie; Harris, Robert J.; Dong, Jiayin; Segura-Cox, Dominique; Tobin, John J.; Sadavoy, Sarah; Li, Zhi-Yun; Dunham, Michael; Perez, Laura M.; Chandler, Claire J.; Kratter, Kaitlin M.; Melis, Carl; Chiang, Hsin-Fang

    2017-01-01

    Relatively evolved (~ 1 Myr old) protostars with little residual natal envelope, but massive disks, are commonly assumed to be the sites of ongoing planet formation. Critical to our study of these objects is information about the available mass reservior and dust structure, as they directly tie in to how much mass is available for planets as well as the modes of planet formation that occur (i.e., core-accretion vs. gravitational instability). Millimeter-wave observations provide this critical information as continuum emission is relatively optically thin, allowing for mass estimates, and the availability of high-resolution interferometry, allowing structure constraints. We present high-resolution observations of the population of Class II protostars in the Rho-Ophiuchus cloud (d ~ 130 pc). Our survey observed ~50 of these older protostars at 870µm, using the Atacama Large Millimeter/submillimeter Array (ALMA). Out of these sources, there are ~10 transition disks, where we see a ring of dust emission surrounding the central protostar -- indicative of ongoing planet formation -- as well as many binary systems. Both of these stages have implications for star and planet formation. We present results from both 1-D and 2-D disk modeling, where we try to understand disk substructure that might indicate on-going planet formation, in particular, transition disk cavities, disk gaps, and asymmetries in the dust emission.

  11. Calving seismicity from iceberg-sea surface interactions

    USGS Publications Warehouse

    Bartholomaus, T.C.; Larsen, C.F.; O'Neel, S.; West, M.E.

    2012-01-01

    Iceberg calving is known to release substantial seismic energy, but little is known about the specific mechanisms that produce calving icequakes. At Yahtse Glacier, a tidewater glacier on the Gulf of Alaska, we draw upon a local network of seismometers and focus on 80 hours of concurrent, direct observation of the terminus to show that calving is the dominant source of seismicity. To elucidate seismogenic mechanisms, we synchronized video and seismograms to reveal that the majority of seismic energy is produced during iceberg interactions with the sea surface. Icequake peak amplitudes coincide with the emergence of high velocity jets of water and ice from the fjord after the complete submergence of falling icebergs below sea level. These icequakes have dominant frequencies between 1 and 3 Hz. Detachment of an iceberg from the terminus produces comparatively weak seismic waves at frequencies between 5 and 20 Hz. Our observations allow us to suggest that the most powerful sources of calving icequakes at Yahtse Glacier include iceberg-sea surface impact, deceleration under the influence of drag and buoyancy, and cavitation. Numerical simulations of seismogenesis during iceberg-sea surface interactions support our observational evidence. Our new understanding of iceberg-sea surface interactions allows us to reattribute the sources of calving seismicity identified in earlier studies and offer guidance for the future use of seismology in monitoring iceberg calving.

  12. The influence of material anisotropy on vibration at onset in a three-dimensional vocal fold model

    PubMed Central

    Zhang, Zhaoyan

    2014-01-01

    Although vocal folds are known to be anisotropic, the influence of material anisotropy on vocal fold vibration remains largely unknown. Using a linear stability analysis, phonation onset characteristics were investigated in a three-dimensional anisotropic vocal fold model. The results showed that isotropic models had a tendency to vibrate in a swing-like motion, with vibration primarily along the superior-inferior direction. Anterior-posterior (AP) out-of-phase motion was also observed and large vocal fold vibration was confined to the middle third region along the AP length. In contrast, increasing anisotropy or increasing AP-transverse stiffness ratio suppressed this swing-like motion and allowed the vocal fold to vibrate in a more wave-like motion with strong medial-lateral motion over the entire medial surface. Increasing anisotropy also suppressed the AP out-of-phase motion, allowing the vocal fold to vibrate in phase along the entire AP length. Results also showed that such improvement in vibration pattern was the most effective with large anisotropy in the cover layer alone. These numerical predictions were consistent with previous experimental observations using self-oscillating physical models. It was further hypothesized that these differences may facilitate complete glottal closure in finite-amplitude vibration of anisotropic models as observed in recent experiments. PMID:24606284

  13. Observing the formation of ice and organic crystals in active sites

    PubMed Central

    Campbell, James M.; Meldrum, Fiona C.; Christenson, Hugo K.

    2017-01-01

    Heterogeneous nucleation is vital to a wide range of areas as diverse as ice nucleation on atmospheric aerosols and the fabrication of high-performance thin films. There is excellent evidence that surface topography is a key factor in directing crystallization in real systems; however, the mechanisms by which nanoscale pits and pores promote nucleation remain unclear. Here, we use natural cleavage defects on Muscovite mica to investigate the activity of topographical features in the nucleation from vapor of ice and various organic crystals. Direct observation of crystallization within surface pockets using optical microscopy and also interferometry demonstrates that these sharply acute features provide extremely effective nucleation sites and allows us to determine the mechanism by which this occurs. A confined phase is first seen to form along the apex of the wedge and then grows out of the pocket opening to generate a bulk crystal after a threshold saturation has been achieved. Ice nucleation proceeds in a comparable manner, although our resolution is insufficient to directly observe a condensate before the growth of a bulk crystal. These results provide insight into the mechanism of crystal deposition from vapor on real surfaces, where this will ultimately enable us to use topography to control crystal deposition on surfaces. They are also particularly relevant to our understanding of processes such as cirrus cloud formation, where such topographical features are likely candidates for the “active sites” that make clay particles effective nucleants for ice in the atmosphere. PMID:27994140

  14. The evolution of early-type galaxies in nearby clusters: breaking the age-metallicity degeneracy with Spitzer IRS Blue Peak-Up Imaging

    NASA Astrophysics Data System (ADS)

    Bressan, Alessandro; Buson, Lucio; Clemens, Marcel; Danese, Luigi; Granato, Gian Luigi; Panuzzo, Pasquale; Rampazzo, Roberto; Silva, Laura; Valdes, Jose Ramon

    2005-06-01

    We have shown with Cycle 1 observations that Spitzer has the capability of disentangling age and metallicity in old stellar populations. By looking to the broad emission feature left by dust enshrouded asymptotic giant branch stars above 9.7 microns, Spitzer IRS can provide direct evidence that the colour- magnitude relation of Virgo ellipticals is mainly driven by metallicity. However, with the IRS spectrograph we can only probe the bright tail of the colour-magnitude relation, and only in the nearest cluster. We propose to use IRS Blue Peak-Up, the only Spitzer band that looks directly in the core of that spectral feature, to reach fainter galaxies. We will perform a thorough investigation of early type galaxies along the colour-magnitude relation in Virgo and in Coma clusters. These observations, when coupled with already existing IRAC and Optical-NIR observations, will allow a) an unbiased census of the stellar populations in cluster early type galaxies; b) an estimate of the AGB material recycled into the ISM in these systems; c) a direct check of the universality of the colour- magnitude relation on a wide range of magnitudes; d) a spatial study of the stellar populations within the galaxies, e.g. investigating differences between bulge and disk populations within S0; e) the most secure reference frame with which to compare the evolution of early type galaxies in other environments (groups and field).

  15. Spectral Rate Theory for Two-State Kinetics

    NASA Astrophysics Data System (ADS)

    Prinz, Jan-Hendrik; Chodera, John D.; Noé, Frank

    2014-02-01

    Classical rate theories often fail in cases where the observable(s) or order parameter(s) used is a poor reaction coordinate or the observed signal is deteriorated by noise, such that no clear separation between reactants and products is possible. Here, we present a general spectral two-state rate theory for ergodic dynamical systems in thermal equilibrium that explicitly takes into account how the system is observed. The theory allows the systematic estimation errors made by standard rate theories to be understood and quantified. We also elucidate the connection of spectral rate theory with the popular Markov state modeling approach for molecular simulation studies. An optimal rate estimator is formulated that gives robust and unbiased results even for poor reaction coordinates and can be applied to both computer simulations and single-molecule experiments. No definition of a dividing surface is required. Another result of the theory is a model-free definition of the reaction coordinate quality. The reaction coordinate quality can be bounded from below by the directly computable observation quality, thus providing a measure allowing the reaction coordinate quality to be optimized by tuning the experimental setup. Additionally, the respective partial probability distributions can be obtained for the reactant and product states along the observed order parameter, even when these strongly overlap. The effects of both filtering (averaging) and uncorrelated noise are also examined. The approach is demonstrated on numerical examples and experimental single-molecule force-probe data of the p5ab RNA hairpin and the apo-myoglobin protein at low pH, focusing here on the case of two-state kinetics.

  16. TESTING THE NO-HAIR THEOREM WITH OBSERVATIONS IN THE ELECTROMAGNETIC SPECTRUM. II. BLACK HOLE IMAGES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Johannsen, Tim; Psaltis, Dimitrios, E-mail: timj@physics.arizona.ed, E-mail: dpsaltis@email.arizona.ed

    2010-07-20

    According to the no-hair theorem, all astrophysical black holes are fully described by their masses and spins. This theorem can be tested observationally by measuring (at least) three different multipole moments of the spacetimes of black holes. In this paper, we analyze images of black holes within a framework that allows us to calculate observables in the electromagnetic spectrum as a function of the mass, spin, and, independently, the quadrupole moment of a black hole. We show that a deviation of the quadrupole moment from the expected Kerr value leads to images of black holes that are either prolate ormore » oblate depending on the sign and magnitude of the deviation. In addition, there is a ring-like structure around the black hole shadow with a diameter of {approx}10 black hole masses that is substantially brighter than the image of the underlying accretion flow and that is independent of the astrophysical details of accretion flow models. We show that the shape of this ring depends directly on the mass, spin, and quadrupole moment of the black hole and can be used for an independent measurement of all three parameters. In particular, we demonstrate that this ring is highly circular for a Kerr black hole with a spin a {approx}< 0.9 M, independent of the observer's inclination, but becomes elliptical and asymmetric if the no-hair theorem is violated. Near-future very long baseline interferometric observations of Sgr A* will image this ring and may allow for an observational test of the no-hair theorem.« less

  17. Adaptive Optics Observations of Exoplanets, Brown Dwarfs, and Binary Stars

    NASA Astrophysics Data System (ADS)

    Hinkley, Sasha

    2012-04-01

    The current direct observations of brown dwarfs and exoplanets have been obtained using instruments not specifically designed for overcoming the large contrast ratio between the host star and any wide-separation faint companions. However, we are about to witness the birth of several new dedicated observing platforms specifically geared towards high contrast imaging of these objects. The Gemini Planet Imager, VLT-SPHERE, Subaru HiCIAO, and Project 1640 at the Palomar 5m telescope will return images of numerous exoplanets and brown dwarfs over hundreds of observing nights in the next five years. Along with diffraction-limited coronagraphs and high-order adaptive optics, these instruments also will return spectral and polarimetric information on any discovered targets, giving clues to their atmospheric compositions and characteristics. Such spectral characterization will be key to forming a detailed theory of comparative exoplanetary science which will be widely applicable to both exoplanets and brown dwarfs. Further, the prevalence of aperture masking interferometry in the field of high contrast imaging is also allowing observers to sense massive, young planets at solar system scales (~3-30 AU)- separations out of reach to conventional direct imaging techniques. Such observations can provide snapshots at the earliest phases of planet formation-information essential for constraining formation mechanisms as well as evolutionary models of planetary mass companions. As a demonstration of the power of this technique, I briefly review recent aperture masking observations of the HR 8799 system. Moreover, all of the aforementioned techniques are already extremely adept at detecting low-mass stellar companions to their target stars, and I present some recent highlights.

  18. Within a Stone's Throw: Proximal Geolocation of Internet Users via Covert Wireless Signaling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Paul, Nathanael R; Shue, Craig; Taylor, Curtis

    While Internet users may often believe they have anonymity online, a culmination of technologies and recent research may allow an adversary to precisely locate an online user s geophysical location. In many cases, such as peer-to-peer applications, an adversary can easily use a target s IP address to quickly obtain the general geographical location of the target. Recent research has scoped this general area to a 690m (0.43 mile) radius circle. In this work, we show how an adversary can exploit Internet communication for geophysical location by embedding covert signals in communication with a target on a remote wireless localmore » area network. We evaluated the approach in two common real-world settings: a residential neighborhood and an apartment building. In the neighborhood case, we used a single-blind trial in which an observer located a target network to within three houses in less than 40 minutes. Directional antennas may have allowed even more precise geolocation. This approach had only a 0.38% false positive rate, despite 24,000 observed unrelated packets and many unrelated networks. This low rate allowed the observer to exclude false locations and continue searching for the target. Our results enable law enforcement or copyright holders to quickly locate online Internet users without requiring time-consuming subpoenas to Internet Service Providers. Other privacy use cases include rapidly locating individuals based on their online speech or interests. We hope to raise awareness of these issues and to spur discussion on privacy and geolocating techniques.« less

  19. Atomic quantum corrals for Bose-Einstein condensates

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xiong Hongwei; Kavli Institute for Theoretical Physics China, Chinese Academy of Sciences, Beijing 100190; Wu Biao

    2010-11-15

    We consider the dynamics of Bose-Einstein condensates in a corral-like potential. Compared to the electronic quantum corrals, the atomic quantum corrals have the advantages of allowing direct and convenient observation of the wave dynamics, together with adjustable interaction strength. Our numerical study shows that these advantages not only allow exploration of the rich dynamical structures in the density distribution but also make the corrals useful in many other aspects. In particular, the corrals for atoms can be arranged into a stadium shape for the experimental visualization of quantum chaos, which has been elusive with electronic quantum corrals. The density correlationmore » is used to describe quantitatively the dynamical quantum chaos. Furthermore, we find that the interatomic interaction can greatly enhance the dynamical quantum chaos, for example, inducing a chaotic behavior even in circle-shaped corrals.« less

  20. Probing sub-GeV dark matter-baryon scattering with cosmological observables

    NASA Astrophysics Data System (ADS)

    Xu, Weishuang Linda; Dvorkin, Cora; Chael, Andrew

    2018-05-01

    We derive new limits on the elastic scattering cross section between baryons and dark matter using cosmic microwave background data from the Planck satellite and measurements of the Lyman-alpha forest flux power spectrum from the Sloan Digital Sky Survey. Our analysis addresses generic cross sections of the form σ ∝vn , where v is the dark matter-baryon relative velocity, allowing for constraints on the cross section independent of specific particle physics models. We include high-ℓ polarization data from Planck in our analysis, improving over previous constraints. We apply a more careful treatment of dark matter thermal evolution than previously done, allowing us to extend our constraints down to dark matter masses of ˜MeV . We show in this work that cosmological probes are complementary to current direct detection and astrophysical searches.

  1. Spatially resolved and time-resolved imaging of transport of indirect excitons in high magnetic fields

    NASA Astrophysics Data System (ADS)

    Dorow, C. J.; Hasling, M. W.; Calman, E. V.; Butov, L. V.; Wilkes, J.; Campman, K. L.; Gossard, A. C.

    2017-06-01

    We present the direct measurements of magnetoexciton transport. Excitons give the opportunity to realize the high magnetic-field regime for composite bosons with magnetic fields of a few tesla. Long lifetimes of indirect excitons allow the study of kinetics of magnetoexciton transport with time-resolved optical imaging of exciton photoluminescence. We performed spatially, spectrally, and time-resolved optical imaging of transport of indirect excitons in high magnetic fields. We observed that an increasing magnetic field slows down magnetoexciton transport. The time-resolved measurements of the magnetoexciton transport distance allowed for an experimental estimation of the magnetoexciton diffusion coefficient. An enhancement of the exciton photoluminescence energy at the laser excitation spot was found to anticorrelate with the exciton transport distance. A theoretical model of indirect magnetoexciton transport is presented and is in agreement with the experimental data.

  2. Optical and electrical properties of bismuth-sulfide (Bi2S3) thin films prepared by thermal evaporation.

    NASA Astrophysics Data System (ADS)

    Mahmoud, Siham; Sharaf, Fouad

    Thin films of Bi2S3, of thickness in the range 300 to 500 nm, were produced by thermal evaporation technique. The reaction consisted in depositing the two elements (bismuth and sulfur) from a boat source and allowing their atoms to interdiffuse to form the compound during the deposition on quartz substrates. The material has been characterized by X-ray studies, optical and electrical measurements. When these films were annealed at 353 K, 393 K and 453 K for 5 hours, a nearly amorphous to polycrystalline transition was observed. The absorption coefficient revealed the existence of an allowed direct transition with Eg = 1.56 eV. The activation energies for electrical conduction in low and high temperature regions are 0.28 eV and 0.73 eV, respectively.

  3. High speed direct imaging of thin metal film ablation by movie-mode dynamic transmission electron microscopy

    PubMed Central

    Hihath, Sahar; Santala, Melissa K.; Cen, Xi; Campbell, Geoffrey; van Benthem, Klaus

    2016-01-01

    Obliteration of matter by pulsed laser beams is not only prevalent in science fiction movies, but finds numerous technological applications ranging from additive manufacturing over machining of micro- and nanostructured features to health care. Pulse lengths ranging from femtoseconds to nanoseconds are utilized at varying laser beam energies and pulse lengths, and enable the removal of nanometric volumes of material. While the mechanisms for removal of material by laser irradiation, i.e., laser ablation, are well understood on the micrometer length scale, it was previously impossible to directly observe obliteration processes on smaller scales due to experimental limitations for the combination of nanometer spatial and nanosecond temporal resolution. Here, we report the direct observation of metal thin film ablation from a solid substrate through dynamic transmission electron microscopy. Quantitative analysis reveals liquid-phase dewetting of the thin-film, followed by hydrodynamic sputtering of nano- to submicron sized metal droplets. We discovered unexpected fracturing of the substrate due to evolving thermal stresses. This study confirms that hydrodynamic sputtering remains a valid mechanism for droplet expulsion on the nanoscale, while irradiation induced stress fields represent limit laser processing of nanostructured materials. Our results allow for improved safety during laser ablation in manufacturing and medical applications. PMID:26965073

  4. High speed direct imaging of thin metal film ablation by movie-mode dynamic transmission electron microscopy

    DOE PAGES

    Hihath, Sahar; Santala, Melissa K.; Cen, Xi; ...

    2016-03-11

    Obliteration of matter by pulsed laser beams is not only prevalent in science fiction movies, but finds numerous technological applications ranging from additive manufacturing over machining of micro- and nanostructured features to health care. Pulse lengths ranging from femtoseconds to nanoseconds are utilized at varying laser beam energies and pulse lengths, and enable the removal of nanometric volumes of material. While the mechanisms for removal of material by laser irradiation, i.e., laser ablation, are well understood on the micrometer length scale, it was previously impossible to directly observe obliteration processes on smaller scales due to experimental limitations for the combinationmore » of nanometer spatial and nanosecond temporal resolution. Here, we report the direct observation of metal thin film ablation from a solid substrate through dynamic transmission electron microscopy. Quantitative analysis reveals liquid-phase dewetting of the thin-film, followed by hydrodynamic sputtering of nano- to submicron sized metal droplets. We discovered unexpected fracturing of the substrate due to evolving thermal stresses. This study confirms that hydrodynamic sputtering remains a valid mechanism for droplet expulsion on the nanoscale, while irradiation induced stress fields represent limit laser processing of nanostructured materials. Ultimately, our results allow for improved safety during laser ablation in manufacturing and medical applications.« less

  5. High speed direct imaging of thin metal film ablation by movie-mode dynamic transmission electron microscopy

    NASA Astrophysics Data System (ADS)

    Hihath, Sahar; Santala, Melissa K.; Cen, Xi; Campbell, Geoffrey; van Benthem, Klaus

    2016-03-01

    Obliteration of matter by pulsed laser beams is not only prevalent in science fiction movies, but finds numerous technological applications ranging from additive manufacturing over machining of micro- and nanostructured features to health care. Pulse lengths ranging from femtoseconds to nanoseconds are utilized at varying laser beam energies and pulse lengths, and enable the removal of nanometric volumes of material. While the mechanisms for removal of material by laser irradiation, i.e., laser ablation, are well understood on the micrometer length scale, it was previously impossible to directly observe obliteration processes on smaller scales due to experimental limitations for the combination of nanometer spatial and nanosecond temporal resolution. Here, we report the direct observation of metal thin film ablation from a solid substrate through dynamic transmission electron microscopy. Quantitative analysis reveals liquid-phase dewetting of the thin-film, followed by hydrodynamic sputtering of nano- to submicron sized metal droplets. We discovered unexpected fracturing of the substrate due to evolving thermal stresses. This study confirms that hydrodynamic sputtering remains a valid mechanism for droplet expulsion on the nanoscale, while irradiation induced stress fields represent limit laser processing of nanostructured materials. Our results allow for improved safety during laser ablation in manufacturing and medical applications.

  6. Dependence of the duration of geomagnetic polarity reversals on site latitude.

    PubMed

    Clement, Bradford M

    2004-04-08

    An important constraint on the processes governing the geodynamo--the flow in the outer core responsible for generating Earth's magnetic field--is the duration of geomagnetic polarity reversals; that is, how long it takes for Earth's magnetic field to reverse. It is generally accepted that Earth's magnetic field strength drops to low levels during polarity reversals, and the field direction progresses through a 180 degrees change while the field is weak. The time it takes for this process to happen, however, remains uncertain, with estimates ranging from a few thousand up to 28,000 years. Here I present an analysis of the available sediment records of the four most recent polarity reversals. These records yield an average estimate of about 7,000 years for the time it takes for the directional change to occur. The variation about this mean duration is not random, but instead varies with site latitude, with shorter durations observed at low-latitude sites, and longer durations observed at mid- to high-latitude sites. Such variation of duration with site latitude is predicted by simple geometrical reversal models, in which non-dipole fields are allowed to persist while the axial dipole decays through zero and then builds in the opposite direction, and provides a constraint on numerical dynamo models.

  7. Origins and Scaling of Hot-Electron Preheat in Ignition-Scale Direct-Drive Inertial Confinement Fusion Experiments.

    PubMed

    Rosenberg, M J; Solodov, A A; Myatt, J F; Seka, W; Michel, P; Hohenberger, M; Short, R W; Epstein, R; Regan, S P; Campbell, E M; Chapman, T; Goyon, C; Ralph, J E; Barrios, M A; Moody, J D; Bates, J W

    2018-02-02

    Planar laser-plasma interaction (LPI) experiments at the National Ignition Facility (NIF) have allowed access for the first time to regimes of electron density scale length (∼500 to 700  μm), electron temperature (∼3 to 5 keV), and laser intensity (6 to 16×10^{14}  W/cm^{2}) that are relevant to direct-drive inertial confinement fusion ignition. Unlike in shorter-scale-length plasmas on OMEGA, scattered-light data on the NIF show that the near-quarter-critical LPI physics is dominated by stimulated Raman scattering (SRS) rather than by two-plasmon decay (TPD). This difference in regime is explained based on absolute SRS and TPD threshold considerations. SRS sidescatter tangential to density contours and other SRS mechanisms are observed. The fraction of laser energy converted to hot electrons is ∼0.7% to 2.9%, consistent with observed levels of SRS. The intensity threshold for hot-electron production is assessed, and the use of a Si ablator slightly increases this threshold from ∼4×10^{14} to ∼6×10^{14}  W/cm^{2}. These results have significant implications for mitigation of LPI hot-electron preheat in direct-drive ignition designs.

  8. Direct Aerosol Radiative Effects and Heating Rates: Results from the 2016 and 2017 ORACLES Field Campaigns

    NASA Astrophysics Data System (ADS)

    Cochrane, S.; Schmidt, S.; Chen, H.; Pilewskie, P.; Redemann, J.; LeBlanc, S. E.; Platnick, S. E.; Meyer, K.; Ferrare, R. A.; Burton, S. P.; Hostetler, C. A.; Iwabuchi, H.

    2017-12-01

    The Southeast Atlantic contains a large, semi-permanent cloud deck often overlaid by a thick layer of biomass burning aerosols that has been advected westward from Southern Africa. We will present (a) the direct aerosol radiative effect (b) the albedo value for which the radiative effect transitions from warming to cooling, i.e., the critical albedo, and (c) aerosol and gas absorption and heating rates for this region from the 2016 and 2017 deployments of the NASA ORACLES experiment (ObseRvations of CLouds above Aerosols and their intEractionS). Observations by the Solar Spectral Flux Radiometer (SSFR), Enhanced MODIS Airborne Simulator (eMAS), High Spectral Resolution Lidar (HSRL-2,) and the Spectrometer for Sky-Scanning Sun-Tracking Atmospheric Research (4STAR) are put into context by the 3D radiative transfer model Monte Carlo Atmospheric Radiative Transfer Simulator (MCARaTS), which allows us to determine the aerosol radiative effect especially when inhomogeneous clouds are present. For highly homogeneous scenes, a direct derivation from the measurements is also possible. We give an overview of spectral single scattering albedo, Ångström exponents, and heating rate profiles for the two experiments while also exploring the dependence of the critical albedo on the aerosol properties.

  9. High speed direct imaging of thin metal film ablation by movie-mode dynamic transmission electron microscopy.

    PubMed

    Hihath, Sahar; Santala, Melissa K; Cen, Xi; Campbell, Geoffrey; van Benthem, Klaus

    2016-03-11

    Obliteration of matter by pulsed laser beams is not only prevalent in science fiction movies, but finds numerous technological applications ranging from additive manufacturing over machining of micro- and nanostructured features to health care. Pulse lengths ranging from femtoseconds to nanoseconds are utilized at varying laser beam energies and pulse lengths, and enable the removal of nanometric volumes of material. While the mechanisms for removal of material by laser irradiation, i.e., laser ablation, are well understood on the micrometer length scale, it was previously impossible to directly observe obliteration processes on smaller scales due to experimental limitations for the combination of nanometer spatial and nanosecond temporal resolution. Here, we report the direct observation of metal thin film ablation from a solid substrate through dynamic transmission electron microscopy. Quantitative analysis reveals liquid-phase dewetting of the thin-film, followed by hydrodynamic sputtering of nano- to submicron sized metal droplets. We discovered unexpected fracturing of the substrate due to evolving thermal stresses. This study confirms that hydrodynamic sputtering remains a valid mechanism for droplet expulsion on the nanoscale, while irradiation induced stress fields represent limit laser processing of nanostructured materials. Our results allow for improved safety during laser ablation in manufacturing and medical applications.

  10. Interaction of Convective Organization and Monsoon Precipitation, Atmosphere, Surface and Sea (INCOMPASS)

    NASA Astrophysics Data System (ADS)

    Turner, Andrew; Bhat, Gs; Evans, Jonathan; Marsham, John; Martin, Gill; Parker, Douglas; Taylor, Chris; Bhattacharya, Bimal; Madan, Ranju; Mitra, Ashis; Mrudula, Gm; Muddu, Sekhar; Pattnaik, Sandeep; Rajagopal, En; Tripathi, Sachida

    2015-04-01

    The monsoon supplies the majority of water in South Asia, making understanding and predicting its rainfall vital for the growing population and economy. However, modelling and forecasting the monsoon from days to the season ahead is limited by large model errors that develop quickly, with significant inter-model differences pointing to errors in physical parametrizations such as convection, the boundary layer and land surface. These errors persist into climate projections and many of these errors persist even when increasing resolution. At the same time, a lack of detailed observations is preventing a more thorough understanding of monsoon circulation and its interaction with the land surface: a process governed by the boundary layer and convective cloud dynamics. The INCOMPASS project will support and develop modelling capability in Indo-UK monsoon research, including test development of a new Met Office Unified Model 100m-resolution domain over India. The first UK detachment of the FAAM research aircraft to India, in combination with an intensive ground-based observation campaign, will gather new observations of the surface, boundary layer structure and atmospheric profiles to go with detailed information on the timing of monsoon rainfall. Observations will be focused on transects in the northern plains of India (covering a range of surface types from irrigated to rain-fed agriculture, and wet to dry climatic zones) and across the Western Ghats and rain shadow in southern India (including transitions from land to ocean and across orography). A pilot observational campaign is planned for summer 2015, with the main field campaign to take place during spring/summer 2016. This project will advance our ability to forecast the monsoon, through a programme of measurements and modelling that aims to capture the key surface-atmosphere feedback processes in models. The observational analysis will allow a unique and unprecedented characterization of monsoon processes that will feed directly into model development at the UK Met Office and Indian NCMRWF, through model evaluation at a range of scales and leading to model improvement by working directly with parametrization developers. The project will institute a new long-term series of measurements of land surface fluxes, a particularly unconstrained observation for India, through eddy covariance flux towers. Combined with detailed land surface modelling using the Joint UK Land Environment Simulator (JULES) model, this will allow testing of land surface initialization in monsoon forecasts and improved land-atmosphere coupling.

  11. Size Evolution and Stochastic Models: Explaining Ostracod Size through Probabilistic Distributions

    NASA Astrophysics Data System (ADS)

    Krawczyk, M.; Decker, S.; Heim, N. A.; Payne, J.

    2014-12-01

    The biovolume of animals has functioned as an important benchmark for measuring evolution throughout geologic time. In our project, we examined the observed average body size of ostracods over time in order to understand the mechanism of size evolution in these marine organisms. The body size of ostracods has varied since the beginning of the Ordovician, where the first true ostracods appeared. We created a stochastic branching model to create possible evolutionary trees of ostracod size. Using stratigraphic ranges for ostracods compiled from over 750 genera in the Treatise on Invertebrate Paleontology, we calculated overall speciation and extinction rates for our model. At each timestep in our model, new lineages can evolve or existing lineages can become extinct. Newly evolved lineages are assigned sizes based on their parent genera. We parameterized our model to generate neutral and directional changes in ostracod size to compare with the observed data. New sizes were chosen via a normal distribution, and the neutral model selected new sizes differentials centered on zero, allowing for an equal chance of larger or smaller ostracods at each speciation. Conversely, the directional model centered the distribution on a negative value, giving a larger chance of smaller ostracods. Our data strongly suggests that the overall direction of ostracod evolution has been following a model that directionally pushes mean ostracod size down, shying away from a neutral model. Our model was able to match the magnitude of size decrease. Our models had a constant linear decrease while the actual data had a much more rapid initial rate followed by a constant size. The nuance of the observed trends ultimately suggests a more complex method of size evolution. In conclusion, probabilistic methods can provide valuable insight into possible evolutionary mechanisms determining size evolution in ostracods.

  12. Gyroscopic sensing in the wings of the hawkmoth Manduca sexta: the role of sensor location and directional sensitivity.

    PubMed

    Hinson, Brian T; Morgansen, Kristi A

    2015-10-06

    The wings of the hawkmoth Manduca sexta are lined with mechanoreceptors called campaniform sensilla that encode wing deformations. During flight, the wings deform in response to a variety of stimuli, including inertial-elastic loads due to the wing flapping motion, aerodynamic loads, and exogenous inertial loads transmitted by disturbances. Because the wings are actuated, flexible structures, the strain-sensitive campaniform sensilla are capable of detecting inertial rotations and accelerations, allowing the wings to serve not only as a primary actuator, but also as a gyroscopic sensor for flight control. We study the gyroscopic sensing of the hawkmoth wings from a control theoretic perspective. Through the development of a low-order model of flexible wing flapping dynamics, and the use of nonlinear observability analysis, we show that the rotational acceleration inherent in wing flapping enables the wings to serve as gyroscopic sensors. We compute a measure of sensor fitness as a function of sensor location and directional sensitivity by using the simulation-based empirical observability Gramian. Our results indicate that gyroscopic information is encoded primarily through shear strain due to wing twisting, where inertial rotations cause detectable changes in pronation and supination timing and magnitude. We solve an observability-based optimal sensor placement problem to find the optimal configuration of strain sensor locations and directional sensitivities for detecting inertial rotations. The optimal sensor configuration shows parallels to the campaniform sensilla found on hawkmoth wings, with clusters of sensors near the wing root and wing tip. The optimal spatial distribution of strain directional sensitivity provides a hypothesis for how heterogeneity of campaniform sensilla may be distributed.

  13. Integration across Time Determines Path Deviation Discrimination for Moving Objects

    PubMed Central

    Whitaker, David; Levi, Dennis M.; Kennedy, Graeme J.

    2008-01-01

    Background Human vision is vital in determining our interaction with the outside world. In this study we characterize our ability to judge changes in the direction of motion of objects–a common task which can allow us either to intercept moving objects, or else avoid them if they pose a threat. Methodology/Principal Findings Observers were presented with objects which moved across a computer monitor on a linear path until the midline, at which point they changed their direction of motion, and observers were required to judge the direction of change. In keeping with the variety of objects we encounter in the real world, we varied characteristics of the moving stimuli such as velocity, extent of motion path and the object size. Furthermore, we compared performance for moving objects with the ability of observers to detect a deviation in a line which formed the static trace of the motion path, since it has been suggested that a form of static memory trace may form the basis for these types of judgment. The static line judgments were well described by a ‘scale invariant’ model in which any two stimuli which possess the same two-dimensional geometry (length/width) result in the same level of performance. Performance for the moving objects was entirely different. Irrespective of the path length, object size or velocity of motion, path deviation thresholds depended simply upon the duration of the motion path in seconds. Conclusions/Significance Human vision has long been known to integrate information across space in order to solve spatial tasks such as judgment of orientation or position. Here we demonstrate an intriguing mechanism which integrates direction information across time in order to optimize the judgment of path deviation for moving objects. PMID:18414653

  14. Questioning supports effective transmission of knowledge and increased exploratory learning in pre-kindergarten children.

    PubMed

    Yu, Yue; Landrum, Asheley R; Bonawitz, Elizabeth; Shafto, Patrick

    2018-06-19

    How can education optimize transmission of knowledge while also fostering further learning? Focusing on children at the cusp of formal schooling (N = 180, age = 4.0-6.0 y), we investigate learning after direct instruction by a knowledgeable teacher, after questioning by a knowledgeable teacher, and after questioning by a naïve informant. Consistent with previous findings, instruction by a knowledgeable teacher allows effective information transmission but at the cost of exploration and further learning. Critically, we find a dual benefit for questioning by a knowledgeable teacher: Such pedagogical questioning both effectively transmits knowledge and fosters exploration and further learning, regardless of whether the question was directed to the child or directed to a third party and overheard by the child. These effects are not observed when the same question is asked by a naïve informant. We conclude that a teacher's choice of pedagogical method may differentially influence learning through their choices of how, and how not, to present evidence, with implications for transmission of knowledge and self-directed discovery. © 2018 John Wiley & Sons Ltd.

  15. Directed Thermal Diffusions through Metamaterial Source Illusion with Homogeneous Natural Media

    PubMed Central

    Xu, Guoqiang; Zhang, Haochun; Jin, Liang

    2018-01-01

    Owing to the utilization of transformation optics, many significant research and development achievements have expanded the applications of illusion devices into thermal fields. However, most of the current studies on relevant thermal illusions used to reshape the thermal fields are dependent of certain pre-designed geometric profiles with complicated conductivity configurations. In this paper, we propose a methodology for designing a new class of thermal source illusion devices for achieving directed thermal diffusions with natural homogeneous media. The employments of the space rotations in the linear transformation processes allow the directed thermal diffusions to be independent of the geometric profiles, and the utilization of natural homogeneous media improve the feasibility. Four schemes, with fewer types of homogeneous media filling the functional regions, are demonstrated in transient states. The expected performances are observed in each scheme. The related performance are analyzed by comparing the thermal distribution characteristics and the illusion effectiveness on the measured lines. The findings obtained in this paper see applications in the development of directed diffusions with minimal thermal loss, used in novel “multi-beam” thermal generation, thermal lenses, solar receivers, and waveguide. PMID:29671833

  16. Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study.

    PubMed

    Song, Fujian; Xiong, Tengbin; Parekh-Bhurke, Sheetal; Loke, Yoon K; Sutton, Alex J; Eastwood, Alison J; Holland, Richard; Chen, Yen-Fu; Glenny, Anne-Marie; Deeks, Jonathan J; Altman, Doug G

    2011-08-16

    To investigate the agreement between direct and indirect comparisons of competing healthcare interventions. Meta-epidemiological study based on sample of meta-analyses of randomised controlled trials. Data sources Cochrane Database of Systematic Reviews and PubMed. Inclusion criteria Systematic reviews that provided sufficient data for both direct comparison and independent indirect comparisons of two interventions on the basis of a common comparator and in which the odds ratio could be used as the outcome statistic. Inconsistency measured by the difference in the log odds ratio between the direct and indirect methods. The study included 112 independent trial networks (including 1552 trials with 478,775 patients in total) that allowed both direct and indirect comparison of two interventions. Indirect comparison had already been explicitly done in only 13 of the 85 Cochrane reviews included. The inconsistency between the direct and indirect comparison was statistically significant in 16 cases (14%, 95% confidence interval 9% to 22%). The statistically significant inconsistency was associated with fewer trials, subjectively assessed outcomes, and statistically significant effects of treatment in either direct or indirect comparisons. Owing to considerable inconsistency, many (14/39) of the statistically significant effects by direct comparison became non-significant when the direct and indirect estimates were combined. Significant inconsistency between direct and indirect comparisons may be more prevalent than previously observed. Direct and indirect estimates should be combined in mixed treatment comparisons only after adequate assessment of the consistency of the evidence.

  17. Sensory gating for the initiation of the swing phase in different directions of human infant stepping.

    PubMed

    Pang, Marco Y C; Yang, Jaynie F

    2002-07-01

    Humans can make smooth, continuous transitions in walking direction from forward to backward. Thus, the processing of sensory input must allow a similar continuum of possibilities. Hip extension and reduced load are two important conditions that control the transition from the stance to swing phase during forward stepping in human infants. The purpose of this study was to determine whether the same factors also regulate the initiation of the swing phase in other directions of stepping. Thirty-seven infants between the ages of 5 and 13 months were studied during supported forward and sideways stepping on a treadmill. Disturbances were elicited by placing a piece of cardboard under the foot and pulling the cardboard in different directions. In this way, the leg was displaced in a particular direction and simultaneously unloaded. We observed whether the swing phase was immediately initiated after the application of disturbances in various directions. Electromyography, vertical ground reaction forces, and hip motion in frontal and sagittal planes were recorded. The results showed that the most potent sensory input to initiate the swing phase depends on the direction of stepping. Although low load was always necessary to initiate swing for all directions of walking, the preferred hip position was always one directly opposite the direction of walking. The results indicated the presence of selective gating of sensory input from the legs as a function of the direction of stepping.

  18. Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study

    PubMed Central

    Xiong, Tengbin; Parekh-Bhurke, Sheetal; Loke, Yoon K; Sutton, Alex J; Eastwood, Alison J; Holland, Richard; Chen, Yen-Fu; Glenny, Anne-Marie; Deeks, Jonathan J; Altman, Doug G

    2011-01-01

    Objective To investigate the agreement between direct and indirect comparisons of competing healthcare interventions. Design Meta-epidemiological study based on sample of meta-analyses of randomised controlled trials. Data sources Cochrane Database of Systematic Reviews and PubMed. Inclusion criteria Systematic reviews that provided sufficient data for both direct comparison and independent indirect comparisons of two interventions on the basis of a common comparator and in which the odds ratio could be used as the outcome statistic. Main outcome measure Inconsistency measured by the difference in the log odds ratio between the direct and indirect methods. Results The study included 112 independent trial networks (including 1552 trials with 478 775 patients in total) that allowed both direct and indirect comparison of two interventions. Indirect comparison had already been explicitly done in only 13 of the 85 Cochrane reviews included. The inconsistency between the direct and indirect comparison was statistically significant in 16 cases (14%, 95% confidence interval 9% to 22%). The statistically significant inconsistency was associated with fewer trials, subjectively assessed outcomes, and statistically significant effects of treatment in either direct or indirect comparisons. Owing to considerable inconsistency, many (14/39) of the statistically significant effects by direct comparison became non-significant when the direct and indirect estimates were combined. Conclusions Significant inconsistency between direct and indirect comparisons may be more prevalent than previously observed. Direct and indirect estimates should be combined in mixed treatment comparisons only after adequate assessment of the consistency of the evidence. PMID:21846695

  19. GIANT GROUND LEVEL ENHANCEMENT OF RELATIVISTIC SOLAR PROTONS ON 2005 JANUARY 20. I. SPACESHIP EARTH OBSERVATIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bieber, J. W.; Clem, J.; Evenson, P.

    A ground level enhancement (GLE) is a solar event that accelerates ions (mostly protons) to GeV range energies in such great numbers that ground-based detectors, such as neutron monitors, observe their showers in Earth's atmosphere above the Galactic cosmic ray background. GLEs are of practical interest because an enhanced relativistic ion flux poses a hazard to astronauts, air crews, and aircraft electronics, and provides the earliest direct indication of an impending space radiation storm. The giant GLE of 2005 January 20 was the second largest on record (and largest since 1956), with up to 4200% count rate enhancement at seamore » level. We analyzed data from the Spaceship Earth network, supplemented to comprise 13 polar neutron monitor stations with distinct asymptotic viewing directions and Polar Bare neutron counters at South Pole, to determine the time evolution of the relativistic proton density, energy spectrum, and three-dimensional directional distribution. We identify two energy-dispersive peaks, indicating two solar injections. The relativistic solar protons were initially strongly beamed, with a peak maximum-to-minimum anisotropy ratio over 1000:1. The directional distribution is characterized by an axis of symmetry, determined independently for each minute of data, whose angle from the magnetic field slowly varied from about 60 Degree-Sign to low values and then rose to about 90 Degree-Sign . The extremely high relativistic proton flux from certain directions allowed 10 s tracking of count rates, revealing fluctuations of period {approx}> 2 minutes with up to 50% fractional changes, which we attribute to fluctuations in the axis of symmetry.« less

  20. XMM-Newton publication statistics

    NASA Astrophysics Data System (ADS)

    Ness, J.-U.; Parmar, A. N.; Valencic, L. A.; Smith, R.; Loiseau, N.; Salama, A.; Ehle, M.; Schartel, N.

    2014-02-01

    We assessed the scientific productivity of XMM-Newton by examining XMM-Newton publications and data usage statistics. We analyse 3272 refereed papers, published until the end of 2012, that directly use XMM-Newton data. The SAO/NASA Astrophysics Data System (ADS) was used to provide additional information on each paper including the number of citations. For each paper, the XMM-Newton observation identifiers and instruments used to provide the scientific results were determined. The identifiers were used to access the XMM-{Newton} Science Archive (XSA) to provide detailed information on the observations themselves and on the original proposals. The information obtained from these sources was then combined to allow the scientific productivity of the mission to be assessed. Since around three years after the launch of XMM-Newton there have been around 300 refereed papers per year that directly use XMM-Newton data. After more than 13 years in operation, this rate shows no evidence that it is decreasing. Since 2002, around 100 scientists per year become lead authors for the first time on a refereed paper which directly uses XMM-Newton data. Each refereed XMM-Newton paper receives around four citations per year in the first few years with a long-term citation rate of three citations per year, more than five years after publication. About half of the articles citing XMM-Newton articles are not primarily X-ray observational papers. The distribution of elapsed time between observations taken under the Guest Observer programme and first article peaks at 2 years with a possible second peak at 3.25 years. Observations taken under the Target of Opportunity programme are published significantly faster, after one year on average. The fraction of science time taken until the end of 2009 that has been used in at least one article is {˜ 90} %. Most observations were used more than once, yielding on average a factor of two in usage on available observing time per year. About 20 % of all slew observations have been used in publications. The scientific productivity of XMM-Newton measured by the publication rate, number of new authors and citation rate, remains extremely high with no evidence that it is decreasing after more than 13 years of operations.

  1. Computer simulations for lab experiences in secondary physics

    NASA Astrophysics Data System (ADS)

    Murphy, David Shannon

    Physical science instruction often involves modeling natural systems, such as electricity that possess particles which are invisible to the unaided eye. The effect of these particles' motion is observable, but the particles are not directly observable to humans. Simulations have been developed in physics, chemistry and biology that, under certain circumstances, have been found to allow students to gain insight into the operation of the systems they model. This study compared the use of a DC circuit simulation, a modified simulation, static graphics, and traditional bulbs and wires to compare gains in DC circuit knowledge as measured by the DIRECT instrument, a multiple choice instrument previously developed to assess DC circuit knowledge. Gender, prior DC circuit knowledge and subsets of DC circuit knowledge of students were also compared. The population (n=166) was comprised of high school freshmen students from an eastern Kentucky public school with a population of 1100 students and followed a quantitative quasi experimental research design. Differences between treatment groups were not statistically significant. Keywords: Simulations, Static Images, Science Education, DC Circuit Instruction, Phet.

  2. Vibrational Spectroscopy and Astrobiology

    NASA Technical Reports Server (NTRS)

    Chaban, Galina M.; Kwak, D. (Technical Monitor)

    2001-01-01

    Role of vibrational spectroscopy in solving problems related to astrobiology will be discussed. Vibrational (infrared) spectroscopy is a very sensitive tool for identifying molecules. Theoretical approach used in this work is based on direct computation of anharmonic vibrational frequencies and intensities from electronic structure codes. One of the applications of this computational technique is possible identification of biological building blocks (amino acids, small peptides, DNA bases) in the interstellar medium (ISM). Identifying small biological molecules in the ISM is very important from the point of view of origin of life. Hybrid (quantum mechanics/molecular mechanics) theoretical techniques will be discussed that may allow to obtain accurate vibrational spectra of biomolecular building blocks and to create a database of spectroscopic signatures that can assist observations of these molecules in space. Another application of the direct computational spectroscopy technique is to help to design and analyze experimental observations of ice surfaces of one of the Jupiter's moons, Europa, that possibly contains hydrated salts. The presence of hydrated salts on the surface can be an indication of a subsurface ocean and the possible existence of life forms inhabiting such an ocean.

  3. SNOW LINES AS PROBES OF TURBULENT DIFFUSION IN PROTOPLANETARY DISKS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Owen, James E.

    2014-07-20

    Sharp chemical discontinuities can occur in protoplanetary disks, particularly at ''snow lines'' where a gas-phase species freezes out to form ice grains. Such sharp discontinuities will diffuse out due to the turbulence suspected to drive angular momentum transport in accretion disks. We demonstrate that the concentration gradient—in the vicinity of the snow line—of a species present outside a snow line but destroyed inside is strongly sensitive to the level of turbulent diffusion (provided the chemical and transport timescales are decoupled) and provides a direct measurement of the radial ''Schmidt number'' (the ratio of the angular momentum transport to radial turbulentmore » diffusion). Taking as an example the tracer species N{sub 2}H{sup +}, which is expected to be destroyed inside the CO snow line (as recently observed in TW Hya) we show that ALMA observations possess significant angular resolution to constrain the Schmidt number. Since different turbulent driving mechanisms predict different Schmidt numbers, a direct measurement of the Schmidt number in accretion disks would allow inferences to be made about the nature of the turbulence.« less

  4. Protein aggregation studied by forward light scattering and light transmission analysis

    NASA Astrophysics Data System (ADS)

    Penzkofer, A.; Shirdel, J.; Zirak, P.; Breitkreuz, H.; Wolf, E.

    2007-12-01

    The aggregation of the circadian blue-light photo-receptor cryptochrome from Drosophila melanogaster (dCry) is studied by transmission and forward light scattering measurement in the protein transparent wavelength region. The light scattering in forward direction is caused by Rayleigh scattering which is proportional to the degree of aggregation. The light transmission through the samples in the transparent region is reduced by Mie light scattering in all directions. It depends on the degree of aggregation and the monomer volume fill factor of the aggregates (less total scattering with decreasing monomer volume fill factor of protein globule) allowing a distinction between tightly packed protein aggregation (monomer volume fill factor 1) and loosely packed protein aggregation (monomer volume fill factor less than 1). An increase in aggregation with temperature, concentration, and blue-light exposure is observed. At a temperature of 4 °C and a protein concentration of less than 0.135 mM no dCry aggregation was observed, while at 24 °C and 0.327 mM gelation occurred (loosely packed aggregates occupying the whole solution volume).

  5. Reflected ray retrieval from radio occultation data using radio holographic filtering of wave fields in ray space

    NASA Astrophysics Data System (ADS)

    Gorbunov, Michael E.; Cardellach, Estel; Lauritsen, Kent B.

    2018-03-01

    Linear and non-linear representations of wave fields constitute the basis of modern algorithms for analysis of radio occultation (RO) data. Linear representations are implemented by Fourier Integral Operators, which allow for high-resolution retrieval of bending angles. Non-linear representations include Wigner Distribution Function (WDF), which equals the pseudo-density of energy in the ray space. Representations allow for filtering wave fields by suppressing some areas of the ray space and mapping the field back from the transformed space to the initial one. We apply this technique to the retrieval of reflected rays from RO observations. The use of reflected rays may increase the accuracy of the retrieval of the atmospheric refractivity. Reflected rays can be identified by the visual inspection of WDF or spectrogram plots. Numerous examples from COSMIC data indicate that reflections are mostly observed over oceans or snow, in particular over Antarctica. We introduce the reflection index that characterizes the relative intensity of the reflected ray with respect to the direct ray. The index allows for the automatic identification of events with reflections. We use the radio holographic estimate of the errors of the retrieved bending angle profiles of reflected rays. A comparison of indices evaluated for a large base of events including the visual identification of reflections indicated a good agreement with our definition of reflection index.

  6. STEREO In-situ Data Analysis

    NASA Astrophysics Data System (ADS)

    Schroeder, P. C.; Luhmann, J. G.; Davis, A. J.; Russell, C. T.

    2006-12-01

    STEREO's IMPACT (In-situ Measurements of Particles and CME Transients) investigation provides the first opportunity for long duration, detailed observations of 1 AU magnetic field structures, plasma and suprathermal electrons, and energetic particles at points bracketing Earth's heliospheric location. The PLASTIC instrument takes plasma ion composition measurements completing STEREO's comprehensive in-situ perspective. Stereoscopic/3D information from the STEREO SECCHI imagers and SWAVES radio experiment make it possible to use both multipoint and quadrature studies to connect interplanetary Coronal Mass Ejections (ICME) and solar wind structures to CMEs and coronal holes observed at the Sun. The uniqueness of the STEREO mission requires novel data analysis tools and techniques to take advantage of the mission's full scientific potential. An interactive browser with the ability to create publication-quality plots has been developed which integrates STEREO's in-situ data with data from a variety of other missions including WIND and ACE. Also, an application program interface (API) is provided allowing users to create custom software that ties directly into STEREO's data set. The API allows for more advanced forms of data mining than currently available through most web-based data services. A variety of data access techniques and the development of cross-spacecraft data analysis tools allow the larger scientific community to combine STEREO's unique in-situ data with those of other missions, particularly the L1 missions, and, therefore, to maximize STEREO's scientific potential in gaining a greater understanding of the heliosphere.

  7. A quantitative framework for flower phenotyping in cultivated carnation (Dianthus caryophyllus L.).

    PubMed

    Chacón, Borja; Ballester, Roberto; Birlanga, Virginia; Rolland-Lagan, Anne-Gaëlle; Pérez-Pérez, José Manuel

    2013-01-01

    Most important breeding goals in ornamental crops are plant appearance and flower characteristics where selection is visually performed on direct offspring of crossings. We developed an image analysis toolbox for the acquisition of flower and petal images from cultivated carnation (Dianthus caryophyllus L.) that was validated by a detailed analysis of flower and petal size and shape in 78 commercial cultivars of D. caryophyllus, including 55 standard, 22 spray and 1 pot carnation cultivars. Correlation analyses allowed us to reduce the number of parameters accounting for the observed variation in flower and petal morphology. Convexity was used as a descriptor for the level of serration in flowers and petals. We used a landmark-based approach that allowed us to identify eight main principal components (PCs) accounting for most of the variance observed in petal shape. The effect and the strength of these PCs in standard and spray carnation cultivars are consistent with shared underlying mechanisms involved in the morphological diversification of petals in both subpopulations. Our results also indicate that neighbor-joining trees built with morphological data might infer certain phylogenetic relationships among carnation cultivars. Based on estimated broad-sense heritability values for some flower and petal features, different genetic determinants shall modulate the responses of flower and petal morphology to environmental cues in this species. We believe our image analysis toolbox could allow capturing flower variation in other species of high ornamental value.

  8. Analysis of Residual Acceleration Effects on Transport and Segregation During Directional Solidification of Tin-Bismuth in the MEPHISTO Furnace Facility

    NASA Technical Reports Server (NTRS)

    Alexander J. Iwan D. (Principal Investigator)

    1996-01-01

    The objective of this work is to approach the problem of determining the transport conditions (and effects of residual acceleration) during the plane-front directional solidification of a tin-bismuth alloy under low gravity conditions. The work involves using a combination of 2- and 3-D numerical models, scaling analyses, ID models and the results of ground-based and low-gravity experiments. The latter are to be conducted during the MEPHISTO experiment scheduled for USMP-3 in early 1996. The models will be used to predict the response of the transport conditions and consequent solute segregation in directionally solidifying tin-bismuth melt. Real-time Seebeck voltage variations across a Sn-Bi melt during directional solidification in MEPHISTO on USMP-1 show a distinct variation which can be correlated with thruster firings. The Seebeck voltage measurement is related to the response of the instantaneous average melt composition at the melt-solid interface. This allows a direct comparison of numerical simulations with the Seebeck signals obtained on USMP-1. The effects of such accelerations on composition for a directionally solidifying Sn-Bi alloy have been simulated numerically. USMP-1 acceleration data was used to assist in our choice of acceleration magnitude and orientation. The results show good agreement with experimental observations. The USMP-3 experiments took place earlier this year (February 22 through March 6). There were several differences between the USMP-3 experiments as compared to USMP-1. Firstly a more concentrated alloy was solidified and, secondly, Primary Reaction Control System thruster burns were requested at particular times during four separate growth runs. This allowed us to monitor the response Seebeck response under well-characterized growth conditions. In addition, we carried out simulations during the experiment in order to interpret the Seebeck signal. Preliminary results are described here.

  9. LEAP: An Innovative Direction Dependent Ionospheric Calibration Scheme for Low Frequency Arrays

    NASA Astrophysics Data System (ADS)

    Rioja, María J.; Dodson, Richard; Franzen, Thomas M. O.

    2018-05-01

    The ambitious scientific goals of the SKA require a matching capability for calibration of atmospheric propagation errors, which contaminate the observed signals. We demonstrate a scheme for correcting the direction-dependent ionospheric and instrumental phase effects at the low frequencies and with the wide fields of view planned for SKA-Low. It leverages bandwidth smearing, to filter-out signals from off-axis directions, allowing the measurement of the direction-dependent antenna-based gains in the visibility domain; by doing this towards multiple directions it is possible to calibrate across wide fields of view. This strategy removes the need for a global sky model, therefore all directions are independent. We use MWA results at 88 and 154 MHz under various weather conditions to characterise the performance and applicability of the technique. We conclude that this method is suitable to measure and correct for temporal fluctuations and direction-dependent spatial ionospheric phase distortions on a wide range of scales: both larger and smaller than the array size. The latter are the most intractable and pose a major challenge for future instruments. Moreover this scheme is an embarrassingly parallel process, as multiple directions can be processed independently and simultaneously. This is an important consideration for the SKA, where the current planned architecture is one of compute-islands with limited interconnects. Current implementation of the algorithm and on-going developments are discussed.

  10. A simple modification of the Baermann method for diagnosis of strongyloidiasis.

    PubMed

    Hernández-Chavarría, F; Avendaño, L

    2001-08-01

    The diagnosis of Strongyloides stercoralis infections is routinely made by microscopic observation of larvae in stool samples, a low sensitivity method, or by other, most effective methods, such as the Baermann or agar culture plate methods. We propose in this paper a practical modification of Baermann method. One hundred and six stool samples from alcoholic patients were analyzed using the direct smear test, agar culture plate method, the standard Baermann method, and its proposed modification. For this modification the funnel used in the original version of the method is substituted by a test tube with a rubber stopper, perforated to allow insertion of a pipette tip. The tube with a fecal suspension is inverted over another tube containing 6 ml of saline solution and incubated at 37 degrees C for at least 2 h. The saline solution from the second tube is centrifuged and the pellet is observed microscopically. Larva of S. stercoralis were detected in six samples (5.7%) by the two versions of the Baermann method. Five samples were positive using the agar culture plate method, and only in two samples the larva were observed using direct microscopic observation of fecal smears. Cysts of Endolimax nana and Entamoeba histolytica/dyspar were also detected in the modification of Baermann method. Data obtained by the modified Baermann method suggest that this methodology may helps concentrate larvae of S. stercoralis as efficiently as the original method.

  11. Computational Properties of the Hippocampus Increase the Efficiency of Goal-Directed Foraging through Hierarchical Reinforcement Learning

    PubMed Central

    Chalmers, Eric; Luczak, Artur; Gruber, Aaron J.

    2016-01-01

    The mammalian brain is thought to use a version of Model-based Reinforcement Learning (MBRL) to guide “goal-directed” behavior, wherein animals consider goals and make plans to acquire desired outcomes. However, conventional MBRL algorithms do not fully explain animals' ability to rapidly adapt to environmental changes, or learn multiple complex tasks. They also require extensive computation, suggesting that goal-directed behavior is cognitively expensive. We propose here that key features of processing in the hippocampus support a flexible MBRL mechanism for spatial navigation that is computationally efficient and can adapt quickly to change. We investigate this idea by implementing a computational MBRL framework that incorporates features inspired by computational properties of the hippocampus: a hierarchical representation of space, “forward sweeps” through future spatial trajectories, and context-driven remapping of place cells. We find that a hierarchical abstraction of space greatly reduces the computational load (mental effort) required for adaptation to changing environmental conditions, and allows efficient scaling to large problems. It also allows abstract knowledge gained at high levels to guide adaptation to new obstacles. Moreover, a context-driven remapping mechanism allows learning and memory of multiple tasks. Simulating dorsal or ventral hippocampal lesions in our computational framework qualitatively reproduces behavioral deficits observed in rodents with analogous lesions. The framework may thus embody key features of how the brain organizes model-based RL to efficiently solve navigation and other difficult tasks. PMID:28018203

  12. Probing the reactivity of nucleophile residues in human 2,3-diphosphoglycerate/deoxy-hemoglobin complex by aspecific chemical modifications.

    PubMed

    Scaloni, A; Ferranti, P; De Simone, G; Mamone, G; Sannolo, N; Malorni, A

    1999-06-11

    The use of aspecific methylation reaction in combination with MS procedures has been employed for the characterization of the nucleophilic residues present on the molecular surface of the human 2,3-diphosphoglycerate/deoxy-hemoglobin complex. In particular, direct molecular weight determinations by ESMS allowed to control the reaction conditions, limiting the number of methyl groups introduced in the modified globin chains. A combined LCESMS-Edman degradation approach for the analysis of the tryptic peptide mixtures yielded to the exact identification of methylation sites together with the quantitative estimation of their degree of modification. The reactivities observed were directly correlated with the pKa and the relative surface accessibility of the nucleophilic residues, calculated from the X-ray crystallographic structure of the protein. The results here described indicate that this methodology can be efficiently used in aspecific modification experiments directed to the molecular characterization of the surface topology in proteins and protein complexes.

  13. The DynaMine webserver: predicting protein dynamics from sequence.

    PubMed

    Cilia, Elisa; Pancsa, Rita; Tompa, Peter; Lenaerts, Tom; Vranken, Wim F

    2014-07-01

    Protein dynamics are important for understanding protein function. Unfortunately, accurate protein dynamics information is difficult to obtain: here we present the DynaMine webserver, which provides predictions for the fast backbone movements of proteins directly from their amino-acid sequence. DynaMine rapidly produces a profile describing the statistical potential for such movements at residue-level resolution. The predicted values have meaning on an absolute scale and go beyond the traditional binary classification of residues as ordered or disordered, thus allowing for direct dynamics comparisons between protein regions. Through this webserver, we provide molecular biologists with an efficient and easy to use tool for predicting the dynamical characteristics of any protein of interest, even in the absence of experimental observations. The prediction results are visualized and can be directly downloaded. The DynaMine webserver, including instructive examples describing the meaning of the profiles, is available at http://dynamine.ibsquare.be. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. Engagement of neural circuits underlying 2D spatial navigation in a rodent virtual reality system.

    PubMed

    Aronov, Dmitriy; Tank, David W

    2014-10-22

    Virtual reality (VR) enables precise control of an animal's environment and otherwise impossible experimental manipulations. Neural activity in rodents has been studied on virtual 1D tracks. However, 2D navigation imposes additional requirements, such as the processing of head direction and environment boundaries, and it is unknown whether the neural circuits underlying 2D representations can be sufficiently engaged in VR. We implemented a VR setup for rats, including software and large-scale electrophysiology, that supports 2D navigation by allowing rotation and walking in any direction. The entorhinal-hippocampal circuit, including place, head direction, and grid cells, showed 2D activity patterns similar to those in the real world. Furthermore, border cells were observed, and hippocampal remapping was driven by environment shape, suggesting functional processing of virtual boundaries. These results illustrate that 2D spatial representations can be engaged by visual and rotational vestibular stimuli alone and suggest a novel VR tool for studying rat navigation.

  15. Direct interaction of FtsZ and MreB is required for septum synthesis and cell division in Escherichia coli.

    PubMed

    Fenton, Andrew K; Gerdes, Kenn

    2013-07-03

    How bacteria coordinate cell growth with division is not well understood. Bacterial cell elongation is controlled by actin-MreB while cell division is governed by tubulin-FtsZ. A ring-like structure containing FtsZ (the Z ring) at mid-cell attracts other cell division proteins to form the divisome, an essential protein assembly required for septum synthesis and cell separation. The Z ring exists at mid-cell during a major part of the cell cycle without contracting. Here, we show that MreB and FtsZ of Escherichia coli interact directly and that this interaction is required for Z ring contraction. We further show that the MreB-FtsZ interaction is required for transfer of cell-wall biosynthetic enzymes from the lateral to the mature divisome, allowing cells to synthesise the septum. Our observations show that bacterial cell division is coupled to cell elongation via a direct and essential interaction between FtsZ and MreB.

  16. ICRF heating in a straight, helically symmetric stellarator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jaeger, E.F.; Weitzner, H.; Batchelor, D.B.

    1987-07-01

    Experimental observations of direct ion cyclotron resonant frequency (ICRF) heating at fundamental ion cyclotron resonance on the L-2 stellarator have stimulated interest in the theoretical basis for such heating. In this paper, global solutions for the ICRF wave fields in a helically symmetric, straight stellarator are calculated in the cold plasma limit. The component of the wave electric field parallel to B-vector is assumed zero. Helical symmetry allows Fourier decomposition in the longitudinal (z) direction. The two remaining partial differential equations in tau and phi identical to THETA - hz (h is the helical pitch) are solved by finite differencing.more » Energy absorption and antenna impedance are calculated from an ad hoc collision model. Results for parameters typical of the L-2 and Advanced Toroidal Facility (ATF) stellarators show that direct resonant absorption of the fundamental ion cyclotron resonance occurs mainly near the plasma edge. The magnitude of the absorption is about half that for minority heating at the two-ion hybrid resonance.« less

  17. Direct interaction of FtsZ and MreB is required for septum synthesis and cell division in Escherichia coli

    PubMed Central

    Fenton, Andrew K; Gerdes, Kenn

    2013-01-01

    How bacteria coordinate cell growth with division is not well understood. Bacterial cell elongation is controlled by actin–MreB while cell division is governed by tubulin–FtsZ. A ring-like structure containing FtsZ (the Z ring) at mid-cell attracts other cell division proteins to form the divisome, an essential protein assembly required for septum synthesis and cell separation. The Z ring exists at mid-cell during a major part of the cell cycle without contracting. Here, we show that MreB and FtsZ of Escherichia coli interact directly and that this interaction is required for Z ring contraction. We further show that the MreB–FtsZ interaction is required for transfer of cell-wall biosynthetic enzymes from the lateral to the mature divisome, allowing cells to synthesise the septum. Our observations show that bacterial cell division is coupled to cell elongation via a direct and essential interaction between FtsZ and MreB. PMID:23756461

  18. Observation of gamma ray bursts and flares by the EGRET telescope on the Compton Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Schneid, E. J.; Bertsch, D. L.; Fichtel, C. E.; Hartman, R. C.; Hunter, S. D.; Kwok, P. W.; Mattox, J. R.; Sreekumar, P.; Thompson, D. J.; Kanbach, G.

    1992-01-01

    The Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory has observed energetic gamma ray bursts and flares. On May 3, 1991, EGRET detected a gamma ray burst both in the energy measuring NaI (Tl) scintillator and independently in the spark chamber imaging assembly. The NaI spectra were accumulated by a special BURST mode of EGRET. The spectra were measured over a range from 1 to 200 MeV, in three sequential spectra of 1,2, and 4 seconds. During the peak of the burst, six individual gamma rays were detected in the spark chamber, allowing a determination of the burst arrival direction. The intense flares of June were also detected. A solar flare on June 4 was observed to last for several minutes and for a brief time, less than a minute, had significant emission of gamma rays exceeding 150 MeV.

  19. Design and performance of the spin asymmetries of the nucleon experiment

    NASA Astrophysics Data System (ADS)

    Maxwell, J. D.; Armstrong, W. R.; Choi, S.; Jones, M. K.; Kang, H.; Liyanage, A.; Meziani, Z.-E.; Mulholland, J.; Ndukum, L.; Rondón, O. A.; Ahmidouch, A.; Albayrak, I.; Asaturyan, A.; Ates, O.; Baghdasaryan, H.; Boeglin, W.; Bosted, P.; Brash, E.; Brock, J.; Butuceanu, C.; Bychkov, M.; Carlin, C.; Carter, P.; Chen, C.; Chen, J.-P.; Christy, M. E.; Covrig, S.; Crabb, D.; Danagoulian, S.; Daniel, A.; Davidenko, A. M.; Davis, B.; Day, D.; Deconinck, W.; Deur, A.; Dunne, J.; Dutta, D.; El Fassi, L.; Elaasar, M.; Ellis, C.; Ent, R.; Flay, D.; Frlez, E.; Gaskell, D.; Geagla, O.; German, J.; Gilman, R.; Gogami, T.; Gomez, J.; Goncharenko, Y. M.; Hashimoto, O.; Higinbotham, D. W.; Horn, T.; Huber, G. M.; Jones, M.; Kalantarians, N.; Kang, H. K.; Kawama, D.; Keith, C.; Keppel, C.; Khandaker, M.; Kim, Y.; King, P. M.; Kohl, M.; Kovacs, K.; Kubarovsky, V.; Li, Y.; Liyanage, N.; Luo, W.; Mamyan, V.; Markowitz, P.; Maruta, T.; Meekins, D.; Melnik, Y. M.; Mkrtchyan, A.; Mkrtchyan, H.; Mochalov, V. V.; Monaghan, P.; Narayan, A.; Nakamura, S. N.; Nuruzzaman; Pentchev, L.; Pocanic, D.; Posik, M.; Puckett, A.; Qiu, X.; Reinhold, J.; Riordan, S.; Roche, J.; Sawatzky, B.; Shabestari, M.; Slifer, K.; Smith, G.; Soloviev, L.; Solvignon, P.; Tadevosyan, V.; Tang, L.; Vasiliev, A. N.; Veilleux, M.; Walton, T.; Wesselmann, F.; Wood, S. A.; Yao, H.; Ye, Z.; Zhu, L.

    2018-03-01

    The Spin Asymmetries of the Nucleon Experiment (SANE) performed inclusive, double-polarized electron scattering measurements of the proton at the Continuous Electron Beam Accelerator Facility at Jefferson Lab. A novel detector array observed scattered electrons of four-momentum transfer 2 . 5

  20. General Relativity and Cosmology: Unsolved Questions and Future Directions

    NASA Astrophysics Data System (ADS)

    Debono, Ivan; Smoot, George F.

    2016-09-01

    For the last 100 years, General Relativity (GR) has taken over the gravitational theory mantle held by Newtonian Gravity for the previous 200 years. This article reviews the status of GR in terms of its self-consistency, completeness, and the evidence provided by observations, which have allowed GR to remain the champion of gravitational theories against several other classes of competing theories. We pay particular attention to the role of GR and gravity in cosmology, one of the areas in which one gravity dominates and new phenomena and effects challenge the orthodoxy. We also review other areas where there are likely conflicts pointing to the need to replace or revise GR to represent correctly observations and consistent theoretical framework. Observations have long been key both to the theoretical liveliness and viability of GR.We conclude with a discussion of the likely developments over the next 100 years.

  1. Observing complex action sequences: The role of the fronto-parietal mirror neuron system.

    PubMed

    Molnar-Szakacs, Istvan; Kaplan, Jonas; Greenfield, Patricia M; Iacoboni, Marco

    2006-11-15

    A fronto-parietal mirror neuron network in the human brain supports the ability to represent and understand observed actions allowing us to successfully interact with others and our environment. Using functional magnetic resonance imaging (fMRI), we wanted to investigate the response of this network in adults during observation of hierarchically organized action sequences of varying complexity that emerge at different developmental stages. We hypothesized that fronto-parietal systems may play a role in coding the hierarchical structure of object-directed actions. The observation of all action sequences recruited a common bilateral network including the fronto-parietal mirror neuron system and occipito-temporal visual motion areas. Activity in mirror neuron areas varied according to the motoric complexity of the observed actions, but not according to the developmental sequence of action structures, possibly due to the fact that our subjects were all adults. These results suggest that the mirror neuron system provides a fairly accurate simulation process of observed actions, mimicking internally the level of motoric complexity. We also discuss the results in terms of the links between mirror neurons, language development and evolution.

  2. Direct Observation of Two Proton Radioactivity Using Digital Photography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rykaczewski, Krzysztof Piotr; Pfutzner, M.; Dominik, Wojciech

    2007-01-01

    Recently the observation of a new type of spontaneous radioactive decay has been claimed in which two protons are simultaneously ejected by an atomic nucleus from the ground state1,2,3. Experimental data obtained for the extremely neutron-deficient nuclei 45Fe and 54Zn, were interpreted as the first evidence of such a decay mode which has been sought since 1960.4 However, the technique applied in those studies allowed only measurements of the decay time and the total energy released. Particles emitted in the decay were not identified and the conclusions had to be supported by theoretical arguments. Here we show for the firstmore » time, directly and unambiguously, that 45Fe indeed disintegrates by two-proton decay. Furthermore, we demonstrate that the decay branch of this isotope leads to various particle emission channels including two-proton and three-proton emission. To achieve this result we have developed a new type of detector V the Optical Time Projection Chamber (OTPC) in which digital photography is applied to nuclear physics for the first time. The detector records images of tracks from charged particles, allowing for their unambiguous identification and the reconstruction of decay events in three dimensions. This new and simple technique provides a powerful method to identify exotic decay channels involving emission of charged particles. It is expected that further studies with the OTPC device will yield important information on nuclei located at and beyond the proton drip-line, thus providing new material for testing and improving models of very unstable atomic nuclei.« less

  3. Neuroprosthetic Decoder Training as Imitation Learning.

    PubMed

    Merel, Josh; Carlson, David; Paninski, Liam; Cunningham, John P

    2016-05-01

    Neuroprosthetic brain-computer interfaces function via an algorithm which decodes neural activity of the user into movements of an end effector, such as a cursor or robotic arm. In practice, the decoder is often learned by updating its parameters while the user performs a task. When the user's intention is not directly observable, recent methods have demonstrated value in training the decoder against a surrogate for the user's intended movement. Here we show that training a decoder in this way is a novel variant of an imitation learning problem, where an oracle or expert is employed for supervised training in lieu of direct observations, which are not available. Specifically, we describe how a generic imitation learning meta-algorithm, dataset aggregation (DAgger), can be adapted to train a generic brain-computer interface. By deriving existing learning algorithms for brain-computer interfaces in this framework, we provide a novel analysis of regret (an important metric of learning efficacy) for brain-computer interfaces. This analysis allows us to characterize the space of algorithmic variants and bounds on their regret rates. Existing approaches for decoder learning have been performed in the cursor control setting, but the available design principles for these decoders are such that it has been impossible to scale them to naturalistic settings. Leveraging our findings, we then offer an algorithm that combines imitation learning with optimal control, which should allow for training of arbitrary effectors for which optimal control can generate goal-oriented control. We demonstrate this novel and general BCI algorithm with simulated neuroprosthetic control of a 26 degree-of-freedom model of an arm, a sophisticated and realistic end effector.

  4. Multimodal microscopy of immune cells and melanoma for longitudinal studies

    NASA Astrophysics Data System (ADS)

    Entenberg, David; Aranda, Iana; Li, Yongbiao; Toledo-Crow, Ricardo; Schaer, David; Li, Yanyun

    2006-02-01

    Intravital microscopy of cancer is a well established tool that provides direct visualization of the tumor cycle. It traditionally involves one of several strategies: invasive subcutaneous (SC) implantation of tumors followed by surgical opening of skin flaps for imaging, techniques utilizing skin fold chambers and implanted optical windows or intradermal injections under 200μm from the skin surface. All of these techniques allow the use of fluorescent proteins as markers for biologically significant constituents. However, observation methods utilizing skin-flaps, skin-fold chambers and optical windows are invasive and tend to alter the immune environment of the tissue and/or limit the duration of studies that can be performed. If implanted correctly, intradermally injected tumors can be minimally invasive, will not require biopsies or surgical intervention to observe and are accessible for direct transdermal imaging with a number of in vivo modalities. We present our work in the development of a small animal intravital microscopy workstation that allows the acquisition of different contrast imaging modalities: reflectance confocal, wide field epifluorescence, multiphoton and second harmonic generation (SHG). The images are acquired pair-wise simultaneously and sequentially in time. The aim of our instrumentation is to gather all information generated by the single probing beam via the reflected or back-scattered signal, SHG signal and various fluorescence signals. Additionally, we also present our development of a microscopic tissue navigation technique to mark, label and track sites of interest. This technique enables us to revisit sites periodically and record, with different imaging contrasts, their biological changes over time.

  5. Oxygen Saturation Surrounding Deep Water Formation Events in the Labrador Sea From Argo-O2 Data

    NASA Astrophysics Data System (ADS)

    Wolf, Mitchell K.; Hamme, Roberta C.; Gilbert, Denis; Yashayaev, Igor; Thierry, Virginie

    2018-04-01

    Deep water formation supplies oxygen-rich water to the deep sea, spreading throughout the ocean by means of the global thermohaline circulation. Models suggest that dissolved gases in newly formed deep water do not come to equilibrium with the atmosphere. However, direct measurements during wintertime convection are scarce, and the controls over the extent of these disequilibria are poorly quantified. Here we show that, when convection reached deeper than 800 m, oxygen in the Labrador Sea was consistently undersaturated at -6.1% to -7.6% at the end of convection. Deeper convection resulted in greater undersaturation, while convection ending later in the year resulted in values closer to equilibrium, from which we produce a predictive relationship. We use dissolved oxygen data from six profiling Argo floats in the Labrador Sea between 2003 and 2016, allowing direct observations of wintertime convection. Three of the six optode oxygen sensors displayed substantial average in situ drift of -3.03 μmol O2 kg-1 yr-1 (-0.94% O2 yr-1), which we corrected to stable deepwater oxygen values from repeat ship surveys. Observations of low oxygen intrusions during restratification and a simple mixing calculation demonstrate that lateral processes act to lower the oxygen inventory of the central Labrador Sea. This suggests that the Labrador Sea is a net sink for atmospheric oxygen, but uncertainties in parameterizing gas exchange limit our ability to quantify the net uptake. Our results constrain the oxygen concentration of newly formed Labrador Sea Water and allow more precise estimates of oxygen utilization and nutrient regeneration in this water mass.

  6. The three-dimensional genome organization of Drosophila melanogaster through data integration.

    PubMed

    Li, Qingjiao; Tjong, Harianto; Li, Xiao; Gong, Ke; Zhou, Xianghong Jasmine; Chiolo, Irene; Alber, Frank

    2017-07-31

    Genome structures are dynamic and non-randomly organized in the nucleus of higher eukaryotes. To maximize the accuracy and coverage of three-dimensional genome structural models, it is important to integrate all available sources of experimental information about a genome's organization. It remains a major challenge to integrate such data from various complementary experimental methods. Here, we present an approach for data integration to determine a population of complete three-dimensional genome structures that are statistically consistent with data from both genome-wide chromosome conformation capture (Hi-C) and lamina-DamID experiments. Our structures resolve the genome at the resolution of topological domains, and reproduce simultaneously both sets of experimental data. Importantly, this data deconvolution framework allows for structural heterogeneity between cells, and hence accounts for the expected plasticity of genome structures. As a case study we choose Drosophila melanogaster embryonic cells, for which both data types are available. Our three-dimensional genome structures have strong predictive power for structural features not directly visible in the initial data sets, and reproduce experimental hallmarks of the D. melanogaster genome organization from independent and our own imaging experiments. Also they reveal a number of new insights about genome organization and its functional relevance, including the preferred locations of heterochromatic satellites of different chromosomes, and observations about homologous pairing that cannot be directly observed in the original Hi-C or lamina-DamID data. Our approach allows systematic integration of Hi-C and lamina-DamID data for complete three-dimensional genome structure calculation, while also explicitly considering genome structural variability.

  7. Distributed Assimilation of Satellite-based Snow Extent for Improving Simulated Streamflow in Mountainous, Dense Forests: An Example Over the DMIP2 Western Basins

    NASA Technical Reports Server (NTRS)

    Yatheendradas, Soni; Peters-Lidard, Christa D.; Koren, Victor; Cosgrove, Brian A.; DeGoncalves, Luis G. D.; Smith, Michael; Geiger, James; Cui, Zhengtao; Borak, Jordan; Kumar, Sujay V.; hide

    2012-01-01

    Snow cover area affects snowmelt, soil moisture, evapotranspiration, and ultimately streamflow. For the Distributed Model Intercomparison Project - Phase 2 Western basins, we assimilate satellite-based fractional snow cover area (fSCA) from the Moderate Resolution Imaging Spectroradiometer, or MODIS, into the National Weather Service (NWS) SNOW-17 model. This model is coupled with the NWS Sacramento Heat Transfer (SAC-HT) model inside the National Aeronautics and Space Administration's (NASA) Land Information System. SNOW-17 computes fSCA from snow water equivalent (SWE) values using an areal depletion curve. Using a direct insertion, we assimilate fSCAs in two fully distributed ways: 1) we update the curve by attempting SWE preservation, and 2) we reconstruct SWEs using the curve. The preceding are refinements of an existing simple, conceptually-guided NWS algorithm. Satellite fSCA over dense forests inadequately accounts for below-canopy snow, degrading simulated streamflow upon assimilation during snowmelt. Accordingly, we implement a below-canopy allowance during assimilation. This simplistic allowance and direct insertion are found to be inadequate for improving calibrated results, still degrading them as mentioned above. However, for streamflow volume for the uncalibrated runs, we obtain: (1) substantial to major improvements (64-81 %) as a percentage of the control run residuals (or distance from observations), and (2) minor improvements (16-22 %) as a percentage of observed values. We highlight the need for detailed representations of canopy-snow optical radiative transfer processes in mountainous, dense forest regions if assimilation-based improvements are to be seen in calibrated runs over these areas.

  8. Detailed Characterization of Nearshore Processes During NCEX

    NASA Astrophysics Data System (ADS)

    Holland, K.; Kaihatu, J. M.; Plant, N.

    2004-12-01

    Recent technology advances have allowed the coupling of remote sensing methods with advanced wave and circulation models to yield detailed characterizations of nearshore processes. This methodology was demonstrated as part of the Nearshore Canyon EXperiment (NCEX) in La Jolla, CA during Fall 2003. An array of high-resolution, color digital cameras was installed to monitor an alongshore distance of nearly 2 km out to depths of 25 m. This digital imagery was analyzed over the three-month period through an automated process to produce hourly estimates of wave period, wave direction, breaker height, shoreline position, sandbar location, and bathymetry at numerous locations during daylight hours. Interesting wave propagation patterns in the vicinity of the canyons were observed. In addition, directional wave spectra and swash / surf flow velocities were estimated using more computationally intensive methods. These measurements were used to provide forcing and boundary conditions for the Delft3D wave and circulation model, giving additional estimates of nearshore processes such as dissipation and rip currents. An optimal approach for coupling these remotely sensed observations to the numerical model was selected to yield accurate, but also timely characterizations. This involved assimilation of directional spectral estimates near the offshore boundary to mimic forcing conditions achieved under traditional approaches involving nested domains. Measurements of breaker heights and flow speeds were also used to adaptively tune model parameters to provide enhanced accuracy. Comparisons of model predictions and video observations show significant correlation. As compared to nesting within larger-scale and coarser resolution models, the advantages of providing boundary conditions data using remote sensing is much improved resolution and fidelity. For example, rip current development was both modeled and observed. These results indicate that this approach to data-model coupling is tenable and may be useful in near-real-time characterizations required by many applied scenarios.

  9. Electrical Resistance Tomography to Monitor Mitigation of Metal-Toxic Acid-Leachates Ruby Gulch Waste Rock Repository Gilt Edge Mine Superfund Site, South Dakota USA

    NASA Astrophysics Data System (ADS)

    Versteeg, R.; Heath, G.; Richardson, A.; Paul, D.; Wangerud, K.

    2003-12-01

    At a cyanide heap-leach open-pit mine, 15-million cubic yards of acid-generating sulfides were dumped at the head of a steep-walled mountain valley, with 30 inches/year precipitation generating 60- gallons/minute ARD leachate. Remediation has reshaped the dump to a 70-acre, 3.5:1-sloped geometry, installed drainage benches and runoff diversions, and capped the repository and lined diversions with a polyethylene geomembrane and cover system. Monitoring was needed to evaluate (a) long-term geomembrane integrity, (b) diversion liner integrity and long-term effectiveness, (c) ARD geochemistry, kinetics and pore-gas dynamics within the repository mass, and (d) groundwater interactions. Observation wells were paired with a 600-electrode resistivity survey system. Using near-surface and down-hole electrodes and automated data collection and post-processing, periodic two- and three-dimensional resistivity images are developed to reflect current and changed-conditions in moisture, temperature, geochemical components, and flow-direction analysis. Examination of total resistivity values and time variances between images allows direct observation of liner and cap integrity with precise identification and location of leaks; likewise, if runoff migrates from degraded diversion ditches into the repository zone, there is an accompanying and noticeable change in resistivity values. Used in combination with monitoring wells containing borehole resistivity electrodes (calibrated with direct sampling of dump water/moisture, temperature and pore-gas composition), the resistivity arrays allow at-depth imaging of geochemical conditions within the repository mass. The information provides early indications of progress or deficiencies in de-watering and ARD- mitigation that is the remedy intent. If emerging technologies present opportunities for secondary treatment, deep resistivity images may assist in developing application methods and evaluating the effectiveness of any reagents introduced into the repository mass to further effect changes in oxidation/reduction reactions.

  10. Direct Observation of the Growth of Au-Pd Core-Shell Nanoparticles Using in situ Low-Dose Liquid Cell STEM imaging

    DOE PAGES

    Bhattarai, Nabraj; Prozorov, Tanya

    2016-07-25

    Bimetallic core-shell nanoparticles are widely used as catalysts in several industrial reactions, with core-shell structures permitting facile surface modification and allowing increased stability and durability, and cost-effectiveness of the catalysts. We report, for the first time, on observing the early stages of the formation of Au-Pd core-shell bimetallic nanoparticles via the seed-mediated growth in the presence of reducing agent, while employing the low-dose scanning transmission electron microscopy imaging with the fluid cell in situ. Use of the continuous flow in situ fluid cell platform allows for delivery of reagent solutions and generation of near-native reaction environment in the reaction chamber,more » and permits direct visualization of the early stages of formation of Au-Pd core-shell structures at low dose rate (0.1 e -/(Å 2s)) in the presence of ascorbic acid. No core-shell structures were detected in the absence of reducing agent at the electron dose of 32.6 e -/Å 2. While the core-shell structures formed in situ under the low-dose imaging closely resemble those obtained in solution synthesis, the reaction kinetics in the fluid cell is affected by the radiolysis of liquid reagents induced by electron beam, altering the rate-determining reaction steps. The enhanced reduction of Pd ions leads to initial rapid growth of the nascent Pd shell along the <111> direction at the Au interface, followed by a slower rearrangement of the outer Pd layer. The latter becomes the rate-determining step in the in situ reaction and appears to follow the oriented attachment-like movement to yield a remodeled, compact and stable Au-Pd core-shell nanostructure. Our findings highlight the differences between the two reaction pathways and aid in understanding the mechanism of formation of the core-shell nanostructure in situ.« less

  11. The Philosophy of User Interfaces in HELIO and the Importance of CASSIS

    NASA Astrophysics Data System (ADS)

    Bonnin, X.; Aboudarham, J.; Renié, C.; Csillaghy, A.; Messerotti, M.; Bentley, R. D.

    2012-09-01

    HELIO is a European project funded under FP7 (Project No. 238969). One of its goals as a Heliospheric Virtual Observatory is to provide an easy access to many datasets scattered all over the world, in the fields of Solar physics, Heliophysics, and Planetary magnetospheres. The efficiency of such a tool is very much related to the quality of the user interface. HELIO infrastructure is based on a Service Oriented Architecture (SOA), regrouping a network of standalone components, which allows four main types of interfaces: - HELIO Front End (HFE) is a browser-based user interface, which offers a centralized access to the HELIO main functionalities. Especially, it provides the possibility to reach data directly, or to refine selection by determination of observing characteristics, such as which instrument was observing at that time, which instrument was at this location, etc. - Many services/components provide their own standalone graphical user interface. While one can directly access individually each of these interfaces, they can also be connected together. - Most services also provide direct access for any tools through a public interface. A small java library, called Java API, simplifies this access by providing client stubs for services and shields the user from security, discovery and failover issues. - Workflows capabilities are available in HELIO, allowing complex combination of queries over several services. We want the user to be able to navigate easily, at his needs, through the various interfaces, and possibly use a specific one in order to make much-dedicated queries. We will also emphasize the importance of the CASSIS project (Coordination Action for the integration of Solar System Infrastructure and Science) in encouraging the interoperability necessary to undertake scientific studies that span disciplinary boundaries. If related projects follow the guidelines being developed by CASSIS then using external resources with HELIO will be greatly simplified.

  12. Investigation of Surface Waves in Deep and Shallow Water using Coherent Radars at Grazing Incidence

    NASA Astrophysics Data System (ADS)

    Buckley, M.; Horstmann, J.; Carrasco, R.; Seemann, J.; Stresser, M.

    2016-02-01

    Coherent microwave radars operating at X-band near grazing incidence are utilized to measure the backscatter intensity and Doppler velocity from the small-scale surface roughness of the ocean. The radar backscatter is dependent on the wind and strongly modulated by the surface waves and therefore enables to retrieve the surface wind as well as surface waves. The radar measured Doppler velocities are also modulated by contributions from the wind, current and waves and allow getting additional information on these parameters. In addition coherent marine radars allow to observe breaking waves, which lead to a increase in radar backscatter as well as a strong change of the Doppler speed.Within this presentation we will introduce and validate new methods to measure spectral wave properties such as wave directions, periods and significant wave height from coherent marine radars. The methods have been applied in deep and shallow water and validated to measurements of directional wave riders as well as an Acoustic Wave and Current Profiler. These comparisons show an overall excellent performance of coherent radars for the retrieval of spectral wave properties (e.g. Hs rms of 0.2 m). Furthermore, new methodologies will be presented that enable to observe and quantify wave breaking in deep water as well as in the littoral zone. The above mentioned methods have been applied to investigate the influence of Offshore Wind Farms (OWF) on the wave field with respect to the spectral properties as well as the amount of wave breaking. We will present the results obtained during a cruise in May 2015 within and around the OWF Dantysk in the German Bight of the North Sea, which consist of eighty 3.5 MW wind turbines. In addition we will present our initial results on the investigation of wave dissipation in the littoral zone at the coast of the island Sylt using marine radars, pressure gauges as well as directional wave riders.

  13. High-resolution palaeomagnetic records of the Laschamp geomagnetic excursion from ODP Sites 1061 and 1062

    NASA Astrophysics Data System (ADS)

    Bourne, M. D.; Henderson, G. M.; Thomas, A. L.; Mac Niocaill, C.

    2012-12-01

    The Laschamp geomagnetic excursion (~41 ka) was a brief global deviation in geomagnetic field behaviour from that expected during normal secular variation. Previously published records suggest rapid changes in field direction and a concurrent substantial decrease in field intensity. We present here high-resolution palaeomagnetic records of the Laschamp excursion obtained from two Ocean Drilling Program (ODP) Sites 1061 and 1062 on the Blake-Bahama Outer Ridge (ODP Leg 172) and compare this record with previously published records of the Blake and Iceland Basin Excursions. Relatively high sedimentation rates (>10 cm kyr-1) at these locations allow the determination of transitional field behaviour during the excursion. Rather than assuming a constant sedimentation rate between assigned age tie-points, we employ measurements of 230Thxs concentration in the sediment to assess variations in the sedimentation rates through the core sections of interest. This allows us to better determine the temporal behaviour of the Laschamp excursion with greater accuracy and known uncertainty. The Laschamp excursion at this location appears to be much shorter in duration than the Blake and Iceland Basin excursions. Palaeomagnetic measurements of discrete samples from four cores reveal a single excursional feature, across an interval of 30 cm, associated with a broader palaeointensity low. The excursion is characterised by rapid transitions (less than 500 years) between a stable normal polarity and a partially-reversed, polarity. Peaks in inclination either side of the directional excursion indicate periods of time when the local field is dominated by vertical flux patches. Similar behaviour has been observed in records of the Iceland Basin Excursion from the same region. The palaeointensity record is in good agreement between the two sites. The palaeointensity record shows two minima, where the second dip in intensity is associated with a more limited directional deviation. Similar field intensity behaviour has been observed during the Blake excursion suggesting that the geomagnetic field stability may be reduced for relatively long durations, potentially up to tens of thousands of years.

  14. Nutrient trends through time in Sweden's Baltic Drainage Area

    NASA Astrophysics Data System (ADS)

    Fischer, I.; Destouni, G.; Prieto, C.

    2015-12-01

    Changes in climate and land-use have and will continue to modify regional hydrology, in turn impacting environmental health, agricultural productivity and water resource quality and availability. The Baltic region is an area of interest as the coast spans nine countries- serving over 100 million people. The Baltic Sea contains one of the largest human caused hypoxic dead zones due to eutrophication driven by anthropogenic excess loading of nutrients. Policies to reduce these loads include also international directives and agreements, such as the EU Water Framework Directive, adopted in 2000 to protect and improve water quality throughout the European Union, and the Baltic Sea Action Plan under the Helsinki Commission aimed specifically at reducing the nutrient loading to and mitigating the eutrophication of the Baltic Sea. In light of these policies and amidst the number of studies on the Baltic Sea we ask, using the accessible nutrient and discharge data what does nutrient loading look like today? Are the most excessive loads going down? Observed nutrient and flow time series across Sweden allow for answering these questions, by spatial and temporal trend analysis of loads from various parts of Sweden to the Baltic Sea. Analyzing these observed time series in conjunction with the ecological health status classifications of the EU Water Framework Directive, allows in particular for answering the question if the loads into the water bodies with the poorest water quality, and from those to the Baltic Sea, are improving, being maintained or deteriorating. Such insight is required to contribute to relevant and efficient water and nutrient load management. Furthermore, empirically calculating nutrient loads, rather than only modeling, reveals that the water body health classification may not reflect what water bodies actually contribute the heaviest loads to the Baltic Sea. This work also underscores the importance of comprehensive analysis of all available data from long term monitoring programs over large spatial scales, including large water quality gradients, in order to assess and address water management problems of today and the future.

  15. Resonant micro and nanoelectromechanical systems: Actuation and biological sensing studies

    NASA Astrophysics Data System (ADS)

    Ilic, Bojan

    This thesis explores various actuation mechanisms of resonant nanoelectro-mechanical systems (NEMS) with emphasis directed towards detection of biomolecules. Arrays of bulk and surface micromachined devices, made using conventional thin film fabrication methods, are used to explore the mass loading effects of selective molecular immobilization on the surface of the NEMS resonators. Experimentally measured shift in the first eigenfrequency is correlated to the amount of mass loading from the binding events and verified using theoretical constructs. Under ambient conditions where considerable damping occurs, immunospecific detection of single Escherichia coli O157:H7 cells is demonstrated by measuring the out of plane vibrational resonant mode using an optical deflection system with thermal noise as an excitation mechanism. Further sensitivity enhancement utilizing vacuum encapsulation in conjunction with piezoelectric actuation and tailoring of the cantilever dimensions is demonstrated by measuring mass loading of a nonpathogenic insect baculovirus, single Aminopropyltriethoxysilane (APTS), Hexamethyldisilazane (HMDS) and Octade-cyltrichlorosilane (OTS) monolayers. To highlight the lower detectable mass limit, surface machined NEMS oscillators with integrated circular Au contacts and sub-attogram mass detection sensitivity are used for selective immobilization of dinitrophenyl poly(ethylene glycol) undecanthiol based molecules. Experimental and theoretical elucidation of optical actuation of NEMS cantilevers at large distances from the clamped end is presented. These observations are considered within the theoretical framework of heat transfer and used to measure binding events of single double-stranded deoxyribonucleic acid (dsDNA) molecules to localized gold nanodots near the free end of a NEMS oscillator. Because this method allows direct coupling of energy into the device layer, several modes of in-plane vibrations are observed and employed in shaking off spherical latex particles. Finally, this thesis describes studies of dynamic detection of vibrational characteristics of suspended NEMS oscillators through direct coupling with a micromechanical probe. Changes in the dynamic amplitude and phase of the probe allow the measurement of the mechanical quality factor. Measured spectral response of the NEMS is in good agreement with optical characterization and modelling results.

  16. The polarization compass dominates over idiothetic cues in path integration of desert ants.

    PubMed

    Lebhardt, Fleur; Koch, Julja; Ronacher, Bernhard

    2012-02-01

    Desert ants, Cataglyphis, use the sky's pattern of polarized light as a compass reference for navigation. However, they do not fully exploit the complexity of this pattern, rather - as proposed previously - they assess their walking direction by means of an approximate solution based on a simplified internal template. Approximate rules are error-prone. We therefore asked whether the ants use additional cues to improve the accuracy of directional decisions, and focused on 'idiothetic' cues, i.e. cues based on information from proprioceptors. We trained ants in a channel system that was covered with a polarization filter, providing only a single e-vector direction as a directional 'celestial' cue. Then we observed their homebound runs on a test field, allowing full view of the sky. In crucial experiments, the ants were exposed to a cue conflict, in which sky compass and idiothetic information disagreed, by training them in a straight channel that provided a change in e-vector direction. The results indicated that the polarization information completely dominates over idiothetic cues. Two path segments with different e-vector orientations are combined linearly to a summed home vector. Our data provide additional evidence that Cataglyphis uses a simplified internal template to derive directional information from the sky's polarization pattern.

  17. Shifts of Gamma Phase across Primary Visual Cortical Sites Reflect Dynamic Stimulus-Modulated Information Transfer.

    PubMed

    Besserve, Michel; Lowe, Scott C; Logothetis, Nikos K; Schölkopf, Bernhard; Panzeri, Stefano

    2015-01-01

    Distributed neural processing likely entails the capability of networks to reconfigure dynamically the directionality and strength of their functional connections. Yet, the neural mechanisms that may allow such dynamic routing of the information flow are not yet fully understood. We investigated the role of gamma band (50-80 Hz) oscillations in transient modulations of communication among neural populations by using measures of direction-specific causal information transfer. We found that the local phase of gamma-band rhythmic activity exerted a stimulus-modulated and spatially-asymmetric directed effect on the firing rate of spatially separated populations within the primary visual cortex. The relationships between gamma phases at different sites (phase shifts) could be described as a stimulus-modulated gamma-band wave propagating along the spatial directions with the largest information transfer. We observed transient stimulus-related changes in the spatial configuration of phases (compatible with changes in direction of gamma wave propagation) accompanied by a relative increase of the amount of information flowing along the instantaneous direction of the gamma wave. These effects were specific to the gamma-band and suggest that the time-varying relationships between gamma phases at different locations mark, and possibly causally mediate, the dynamic reconfiguration of functional connections.

  18. Shifts of Gamma Phase across Primary Visual Cortical Sites Reflect Dynamic Stimulus-Modulated Information Transfer

    PubMed Central

    Besserve, Michel; Lowe, Scott C.; Logothetis, Nikos K.; Schölkopf, Bernhard; Panzeri, Stefano

    2015-01-01

    Distributed neural processing likely entails the capability of networks to reconfigure dynamically the directionality and strength of their functional connections. Yet, the neural mechanisms that may allow such dynamic routing of the information flow are not yet fully understood. We investigated the role of gamma band (50–80 Hz) oscillations in transient modulations of communication among neural populations by using measures of direction-specific causal information transfer. We found that the local phase of gamma-band rhythmic activity exerted a stimulus-modulated and spatially-asymmetric directed effect on the firing rate of spatially separated populations within the primary visual cortex. The relationships between gamma phases at different sites (phase shifts) could be described as a stimulus-modulated gamma-band wave propagating along the spatial directions with the largest information transfer. We observed transient stimulus-related changes in the spatial configuration of phases (compatible with changes in direction of gamma wave propagation) accompanied by a relative increase of the amount of information flowing along the instantaneous direction of the gamma wave. These effects were specific to the gamma-band and suggest that the time-varying relationships between gamma phases at different locations mark, and possibly causally mediate, the dynamic reconfiguration of functional connections. PMID:26394205

  19. Deterministic photon-emitter coupling in chiral photonic circuits.

    PubMed

    Söllner, Immo; Mahmoodian, Sahand; Hansen, Sofie Lindskov; Midolo, Leonardo; Javadi, Alisa; Kiršanskė, Gabija; Pregnolato, Tommaso; El-Ella, Haitham; Lee, Eun Hye; Song, Jin Dong; Stobbe, Søren; Lodahl, Peter

    2015-09-01

    Engineering photon emission and scattering is central to modern photonics applications ranging from light harvesting to quantum-information processing. To this end, nanophotonic waveguides are well suited as they confine photons to a one-dimensional geometry and thereby increase the light-matter interaction. In a regular waveguide, a quantum emitter interacts equally with photons in either of the two propagation directions. This symmetry is violated in nanophotonic structures in which non-transversal local electric-field components imply that photon emission and scattering may become directional. Here we show that the helicity of the optical transition of a quantum emitter determines the direction of single-photon emission in a specially engineered photonic-crystal waveguide. We observe single-photon emission into the waveguide with a directionality that exceeds 90% under conditions in which practically all the emitted photons are coupled to the waveguide. The chiral light-matter interaction enables deterministic and highly directional photon emission for experimentally achievable on-chip non-reciprocal photonic elements. These may serve as key building blocks for single-photon optical diodes, transistors and deterministic quantum gates. Furthermore, chiral photonic circuits allow the dissipative preparation of entangled states of multiple emitters for experimentally achievable parameters, may lead to novel topological photon states and could be applied for directional steering of light.

  20. Deterministic photon-emitter coupling in chiral photonic circuits

    NASA Astrophysics Data System (ADS)

    Söllner, Immo; Mahmoodian, Sahand; Hansen, Sofie Lindskov; Midolo, Leonardo; Javadi, Alisa; Kiršanskė, Gabija; Pregnolato, Tommaso; El-Ella, Haitham; Lee, Eun Hye; Song, Jin Dong; Stobbe, Søren; Lodahl, Peter

    2015-09-01

    Engineering photon emission and scattering is central to modern photonics applications ranging from light harvesting to quantum-information processing. To this end, nanophotonic waveguides are well suited as they confine photons to a one-dimensional geometry and thereby increase the light-matter interaction. In a regular waveguide, a quantum emitter interacts equally with photons in either of the two propagation directions. This symmetry is violated in nanophotonic structures in which non-transversal local electric-field components imply that photon emission and scattering may become directional. Here we show that the helicity of the optical transition of a quantum emitter determines the direction of single-photon emission in a specially engineered photonic-crystal waveguide. We observe single-photon emission into the waveguide with a directionality that exceeds 90% under conditions in which practically all the emitted photons are coupled to the waveguide. The chiral light-matter interaction enables deterministic and highly directional photon emission for experimentally achievable on-chip non-reciprocal photonic elements. These may serve as key building blocks for single-photon optical diodes, transistors and deterministic quantum gates. Furthermore, chiral photonic circuits allow the dissipative preparation of entangled states of multiple emitters for experimentally achievable parameters, may lead to novel topological photon states and could be applied for directional steering of light.

Top