Promoting energy efficiency through improved electricity pricing: A mid-project report

NASA Astrophysics Data System (ADS)

Action, J. P.; Kohler, D. F.; Mitchell, B. M.; Park, R. E.

1982-03-01

Five related areas of electricity demand analysis under alternative rate forms were studied. Adjustments by large commercial and industrial customers are examined. Residential demand under time of day (TOD) pricing is examined. A methodology for evaluating alternative rate structures is developed and applied.

Stage Structure of Moral Development: A Comparison of Alternative Models.

ERIC Educational Resources Information Center

Hau, Kit-Tai

This study evaluated the stage structure of several quasi-simplex and non-simplex models of moral development in two domains of moral development in a British and a Chinese sample. Analyses were based on data reported by Sachs (1992): the Chinese sample consisted of 1,005 students from grade 9 to post-college, and the British sample consisted of…

A framework of analysis for field experiments with alternative materials in road construction.

PubMed

François, D; Jullien, A

2009-01-01

In France, a wide variety of alternative materials is produced or exists in the form of stockpiles built up over time. Such materials are distributed over various regions of the territory depending on local industrial development and urbanisation trends. The use of alternative materials at a national scale implies sharing local knowledge and experience. Building a national database on alternative materials for road construction is useful in gathering and sharing information. An analysis of feedback from onsite experiences (back analysis) is essential to improve knowledge on alternative material use in road construction. Back analysis of field studies has to be conducted in accordance with a single common framework. This could enable drawing comparisons between alternative materials and between road applications. A framework for the identification and classification of data used in back analyses is proposed. Since the road structure is an open system, this framework has been based on a stress-response approach at both the material and structural levels and includes a description of external factors applying during the road service life. The proposal has been shaped from a review of the essential characteristics of road materials and structures, as well as from the state of knowledge specific to alternative material characterisation.

Novel Growth Technologies for In Situ Formation of Semiconductor Quantum Wire Structures

DTIC Science & Technology

1994-01-01

as the alternative source for phosphine for the first time. We have developed the Stranski-Krastanow (SK) growth mode for the in-situ formation of InP...tertiarybutylphosphine (TBP) as the alternative source 3 for phosphine for the first time. At growth temperatures of 600oC specular surface morphology and mobilities...semi-insulating hnP buffer layer using ferrocene as the Fe-dopant. For the n-channel in our JFET structure disilane is used to obtain carrier

Syntactic generalization with novel intransitive verbs.

PubMed

Kline, Melissa; Demuth, Katherine

2014-05-01

To understand how children develop adult argument structure, we must understand the nature of syntactic and semantic representations during development. The present studies compare the performance of children aged 2;6 on the two intransitive alternations in English: patient (Daddy is cooking the food/The food is cooking) and agent (Daddy is cooking). Children displayed abstract knowledge of both alternations, producing appropriate syntactic generalizations with novel verbs. These generalizations were adult-like in both flexibility and constraint. Rather than limiting their generalizations to lexicalized frames, children produced sentences with a variety of nouns and pronouns. They also avoided semantic overgeneralizations, producing intransitive sentences that respected the event restrictions and animacy cues. Some generated semantically appropriate agent intransitives when discourse pressure favored patient intransitives, indicating a stronger command of the first alternation. This was in line with frequency distributions in child-directed speech. These findings suggest that children have early access to representations that permit flexible argument structure generalization.

Preliminary Structural Sizing and Alternative Material Trade Study of CEV Crew Module

NASA Technical Reports Server (NTRS)

Bednarcyk, Brett A.; Arnold, Steve M.; Collier, Craig S.; Yarrington, Phillip W.

2007-01-01

This paper presents the results of a preliminary structural sizing and alternate material trade study for NASA s Crew Exploration Vehicle (CEV) Crew Module (CM). This critical CEV component will house the astronauts during ascent, docking with the International Space Station, reentry, and landing. The alternate material design study considers three materials beyond the standard metallic (aluminum alloy) design that resulted from an earlier NASA Smart Buyer Team analysis. These materials are graphite/epoxy composite laminates, discontinuously reinforced SiC/Al (DRA) composites, and a novel integrated panel material/concept known as WebCore. Using the HyperSizer (Collier Research and Development Corporation) structural sizing software and NASTRAN finite element analysis code, a comparison is made among these materials for the three composite CM concepts considered by the 2006 NASA Engineering and Safety Center Composite Crew Module project.

Stiff, Strong Splice For A Composite Sandwich Structure

NASA Technical Reports Server (NTRS)

Schmaling, D.

1991-01-01

New type of splice for composite sandwich structure reduces peak shear stress in structure. Layers of alternating fiber orientation interposed between thin ears in adhesive joint. Developed for structural joint in spar of helicopter rotor blade, increases precision of control over thickness of adhesive at joint. Joint easy to make, requires no additional pieces, and adds little weight.

Land management planning: a method of evaluating alternatives

Treesearch

Andres Weintraub; Richard Adams; Linda Yellin

1982-01-01

A method is described for developing and evaluating alternatives in land management planning. A structured set of 15 steps provides a framework for such an evaluation. when multiple objectives and uncertainty must be considered in the planning process. The method is consistent with other processes used in organizational evaluation, and allows for the interaction of...

Probability model for analyzing fire management alternatives: theory and structure

Treesearch

Frederick W. Bratten

1982-01-01

A theoretical probability model has been developed for analyzing program alternatives in fire management. It includes submodels or modules for predicting probabilities of fire behavior, fire occurrence, fire suppression, effects of fire on land resources, and financial effects of fire. Generalized "fire management situations" are used to represent actual fire...

Superitem Test: An Alternative Assessment Tool to Assess Students' Algebraic Solving Ability

ERIC Educational Resources Information Center

Lian, Lim Hooi; Yew, Wun Thiam; Idris, Noraini

2010-01-01

Superitem test based on the SOLO model (Structure of the Observing Learning Outcome) has become a powerful alternative assessment tool for monitoring the growth of students' cognitive ability in solving mathematics problems. This article focused on developing a superitem test to assess students' algebraic solving ability through interview method.…

Experimental evidence and modelling of drought induced alternative stable soil moisture states

NASA Astrophysics Data System (ADS)

Robinson, David; Jones, Scott; Lebron, Inma; Reinsch, Sabine; Dominguez, Maria; Smith, Andrew; Marshal, Miles; Emmett, Bridget

2017-04-01

The theory of alternative stable states in ecosystems is well established in ecology; however, evidence from manipulation experiments supporting the theory is limited. Developing the evidence base is important because it has profound implications for ecosystem management. Here we show evidence of the existence of alternative stable soil moisture states induced by drought in an upland wet heath. We used a long-term (15 yrs) climate change manipulation experiment with moderate sustained drought, which reduced the ability of the soil to retain soil moisture by degrading the soil structure, reducing moisture retention. Moreover, natural intense droughts superimposed themselves on the experiment, causing an unexpected additional alternative soil moisture state to develop, both for the drought manipulation and control plots; this impaired the soil from rewetting in winter. Our results show the coexistence of three stable states. Using modelling with the Hydrus 1D software package we are able to show the circumstances under which shifts in soil moisture states are likely to occur. Given the new understanding it presents a challenge of how to incorporate feedbacks, particularly related to soil structure, into soil flow and transport models?

Radiation protective structure alternatives for habitats of a lunar base research outpost

NASA Technical Reports Server (NTRS)

Bell, Fred J.; Foo, Lai T.; Mcgrew, William P.

1988-01-01

The solar and galactic cosmic radiation levels on the Moon pose a hazard to extended manned lunar missions. Lunar soil represents an available, economical material to be used for radiation shielding. Several alternatives have been suggested to use lunar soil to protect the inhabitants of a lunar base research outpost from radiation. The Universities Space Research Association has requested that a comparative analysis of the alternatives be performed, with the purpose of developing the most advantageous design. Eight alternatives have been analyzed, including an original design which was developed to satisfy the identified design criteria. The original design consists of a cylindrical module and airlock, partially buried in the lunar soil, at a depth sufficient to achieve adequate radiation shielding. The report includes descriptions of the alternatives considered, the method of analysis used, and the final design selected.

Teacher Observation of Classroom Adaptation--Checklist: Development and Factor Structure

ERIC Educational Resources Information Center

Koth, Christine W.; Bradshaw, Catherine P.; Leaf, Philip J.

2009-01-01

Two studies examined the validity and factor structure of the Teacher Observation of Classroom Adaptation-Checklist, an instrument used to evaluate school-based programs. The checklist is a cost-effective alternative to the original interview format, and the factor structure is consistent across gender, race, age, and time of administration.…

Are Structural Estimates of Auction Models Reasonable? Evidence from Experimental Data

ERIC Educational Resources Information Center

Bajari, Patrick; Hortacsu, Ali

2005-01-01

Recently, economists have developed methods for structural estimation of auction models. Many researchers object to these methods because they find the strict rationality assumptions to be implausible. Using bid data from first-price auction experiments, we estimate four alternative structural models: (1) risk-neutral Bayes-Nash, (2) risk-averse…

Structural dynamics payload loads estimates

NASA Technical Reports Server (NTRS)

Engels, R. C.

1982-01-01

Methods for the prediction of loads on large space structures are discussed. Existing approaches to the problem of loads calculation are surveyed. A full scale version of an alternate numerical integration technique to solve the response part of a load cycle is presented, and a set of short cut versions of the algorithm developed. The implementation of these techniques using the software package developed is discussed.

Factors Affecting the Development of Oxide Scales on Austenitic Stainless Steels during Hot Rolling in Steckel Mills

NASA Astrophysics Data System (ADS)

Cobo, S. J.; Rainforth, W. M.

2008-10-01

The hot rolling of austenitic stainless steels in Steckel Mills introduces particular characteristics to the development of oxides scales and surface structures. In this work, the formation of oxide structures during multipass hot rolling of 302 steel was studied under different sets of processing parameters in a laboratory system designed for the simulation of the Steckel process. The resulting surface structures were characterized by a set of complementary techniques involving scanning electron microscopy, energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD), and glow discharge optical spectroscopy (GDOS). The surface analysis revealed two alternative surface structures: one consisting in a thin protective oxide layer rich in Cr2O3 and the other consisting in thick complex structures containing several successive nonprotective oxide scale and metal layers resulting from a cyclic oxidation pattern involving stages of protective oxidation, chemical breakaway, and duplex oxidation. The critical condition that determined the activation of one mechanism or the other was identified associated with the parabolic rate constant for Cr2O3 growth and the diffusivity of Cr in the alloy. The effects of changes in temperature, deformation, and furnace atmosphere are discussed. Alternatives for controlling scale development are presented.

The need for strategic tax planning among nonprofit hospitals.

PubMed

Smith, Pamela C

2005-01-01

Strategic tax planning issues are important to the nonprofit health care sector, despite its philanthropic mission. The consolidation of the industry has led management to fight for resources and develop alternative strategies for raising money. When management evaluates alternative collaborative structures to increase efficiency, the impact on governance structures must also be considered. The increased governmental scrutiny of joint ventures within the health care sector warrants management's attention as well. The financial incentives must be considered, along with the various tax policy implications of cross-sector collaborations.

Comparative Validity of the Shedler and Westen Assessment Procedure-200

ERIC Educational Resources Information Center

Mullins-Sweatt, Stephanie N.; Widiger, Thomas A.

2008-01-01

A predominant dimensional model of general personality structure is the five-factor model (FFM). Quite a number of alternative instruments have been developed to assess the domains of the FFM. The current study compares the validity of 2 alternative versions of the Shedler and Westen Assessment Procedure (SWAP-200) FFM scales, 1 that was developed…

A framework for an alternatives assessment dashboard for evaluating chemical alternatives applied to flame retardants for electronic applications.

PubMed

Martin, Todd M

2017-05-01

The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are compared using a variety of human health effects, ecotoxicity, and physicochemical properties. Hazard profiles are completed using a variety of online sources and quantitative structure activity relationship models. In the second stage, alternatives are evaluated utilizing an exposure/risk assessment over the entire life cycle. Exposure values are calculated using screening-level near-field and far-field exposure models. The second stage allows one to more accurately compare potential exposure to each alternative and consider additional factors that may not be obvious from separate binned persistence, bioaccumulation, and toxicity scores. The methodology was utilized to compare phosphate-based alternatives for decabromodiphenyl ether (decaBDE) in electronics applications.

Education for Participation: Third World Perspectives.

ERIC Educational Resources Information Center

Swee-Hin, Toh

1987-01-01

Argues that developing nations' educational systems have fallen short of providing requisite skills, knowledge, and values for citizen participation in social, economic, political, and cultural development. Suggests alternative educational structures which would better serve the basic needs and rights of the poor majorities in developing nations.…

Structure and mechanical properties of a multilayer carbide-hardened niobium composite material fabricated by diffusion welding

NASA Astrophysics Data System (ADS)

Korzhov, V. P.; Ershov, A. E.; Stroganova, T. S.; Prokhorov, D. V.

2016-04-01

The structure, the bending strength, and the fracture mechanism of an artificial niobium-based composite material, which is fabricated by high-pressure diffusion welding of multilayer stacks assembled from niobium foils with a two-sided carbon coating, are studied. The microstructure of the composite material is found to consist of alternating relatively plastic layers of the solid solution of carbon in niobium and hardening niobium carbide layers. The room-temperature proportional limit of the developed composite material is threefold that of the composite material fabricated from coating-free niobium foils using the proposed technology. The proportional limit of the developed composite material and the stress corresponding to the maximum load at 1100°C are 500 and 560 MPa, respectively. The developed material is considered as an alternative to Ni-Al superalloys.

Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling.

PubMed

Andreeva, Antonina

2016-06-15

The Structural Classification of Proteins (SCOP) database has facilitated the development of many tools and algorithms and it has been successfully used in protein structure prediction and large-scale genome annotations. During the development of SCOP, numerous exceptions were found to topological rules, along with complex evolutionary scenarios and peculiarities in proteins including the ability to fold into alternative structures. This article reviews cases of structural variations observed for individual proteins and among groups of homologues, knowledge of which is essential for protein structure modelling. © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.

Acquisition Management for Systems-of-Systems: Exploratory Model Development and Experimentation

DTIC Science & Technology

2009-04-22

outputs of the Requirements Development and Logical Analysis processes into alternative design solutions and selects a final design solution. Decision...Analysis Provides the basis for evaluating and selecting alternatives when decisions need to be made. Implementation Yields the lowest-level system... Dependenc y Matrix 1 ⎥ ⎥ ⎥ ⎦ ⎤ ⎢ ⎢ ⎢ ⎣ ⎡ 011 100 110 2 ⎥ ⎥ ⎥ ⎦ ⎤ ⎢ ⎢ ⎢ ⎣ ⎡ 000 100 100 a) Example of SoS b) Model Structure for Example SoS

Evaluation of hydrotropic pretreatment on lignocellulosic biomass.

PubMed

Devendra, Leena P; Kiran Kumar, M; Pandey, Ashok

2016-08-01

The production of cellulosic ethanol from biomass is considered as a promising alternative to fossil fuels, providing a sustainable option for fuels production in an environmentally compatible manner. The presence of lignin poses a significant challenge for obtaining biofuels and bioproducts from biomass. Part of that problem involves understanding fundamental aspects of lignin structure which can provide a pathway for the development of improved technologies for biomass conversion. Hydrotropic pretreatment has several attractive features that make it an attractive alternative for biofuel production. This review highlights the recent developments on hydrotropic pretreatment processes for lignocellulosic biomass on a molecular structure basis for recalcitrance, with emphasis on lignin concerning chemical structure, transformation and recalcitrance. The review also evaluates the hydrotropic delignification in comparison to alkaline delignification on lignin reduction and surface coverage by lignin. The effect of hydrotrope pretreatment on enzymatic saccharification has also been discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

Coupled structural/thermal/electromagnetic analysis/tailoring of graded composite structures

NASA Technical Reports Server (NTRS)

Mcknight, R. L.; Huang, H.; Hartle, M.

1992-01-01

Accomplishments are described for the fourth years effort of a 5-year program to develop a methodology for coupled structural/thermal/electromagnetic analysis/tailoring of graded component structures. These accomplishments include: (1) demonstration of coupled solution capability; (2) alternate CSTEM electromagnetic technology; (3) CSTEM acoustic capability; (4) CSTEM tailoring; (5) CSTEM composite micromechanics using ICAN; and (6) multiple layer elements in CSTEM.

Extended performance solar electric propulsion thrust system study. Volume 3: Tradeoff studies of alternate thrust system configurations

NASA Technical Reports Server (NTRS)

Hawthorne, E. I.

1977-01-01

Several thrust system design concepts were evaluated and compared using the specifications of the most advanced 30 cm engineering model thruster as the technology base. Emphasis was placed on relatively high power missions. The extensions in thruster performance required for the Halley's comet mission were defined and alternative thrust system concepts were designed in sufficient detail for comparing mass, efficiency, reliability, structure, and thermal characteristics. Confirmation testing and analysis of thruster and power-processing components were performed. A baseline design was selected from the alternatives considered, and the design analysis and documentation were refined. A program development plan was formulated that outlines the work structure considered necessary for developing, qualifying, and fabricating the flight hardware for the baseline thrust system within the time frame of a project to rendezvous with Halley's comet. An assessment was made of the costs and risks associated with a baseline thrust system as provided to the mission project under this plan. Critical procurements and interfaces were identified and defined.

Alternative Splicing of Four Trafficking Genes Regulates Myofiber Structure and Skeletal Muscle Physiology.

PubMed

Giudice, Jimena; Loehr, James A; Rodney, George G; Cooper, Thomas A

2016-11-15

During development, transcriptional and post-transcriptional networks are coordinately regulated to drive organ maturation. Alternative splicing contributes by producing temporal-specific protein isoforms. We previously found that genes undergoing splicing transitions during mouse postnatal heart development are enriched for vesicular trafficking and membrane dynamics functions. Here, we show that adult trafficking isoforms are also expressed in adult skeletal muscle and hypothesize that striated muscle utilizes alternative splicing to generate specific isoforms required for function of adult tissue. We deliver morpholinos into flexor digitorum brevis muscles in adult mice to redirect splicing of four trafficking genes to the fetal isoforms. The splicing switch results in multiple structural and functional defects, including transverse tubule (T-tubule) disruption and dihydropyridine receptor alpha (DHPR) and Ryr1 mislocalization, impairing excitation-contraction coupling, calcium handling, and force generation. The results demonstrate a previously unrecognized role for trafficking functions in adult muscle tissue homeostasis and a specific requirement for the adult splice variants. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Atomistic modeling of alternating access of a mitochondrial ADP/ATP membrane transporter with molecular simulations

PubMed Central

Hayashi, Shigehiko

2017-01-01

The mitochondrial ADP/ATP carrier (AAC) is a membrane transporter that exchanges a cytosolic ADP for a matrix ATP. Atomic structures in an outward-facing (OF) form which binds an ADP from the intermembrane space have been solved by X-ray crystallography, and revealed their unique pseudo three-fold symmetry fold which is qualitatively different from pseudo two-fold symmetry of most transporters of which atomic structures have been solved. However, any atomic-level information on an inward-facing (IF) form, which binds an ATP from the matrix side and is fixed by binding of an inhibitor, bongkrekic acid (BA), is not available, and thus its alternating access mechanism for the transport process is unknown. Here, we report an atomic structure of the IF form predicted by atomic-level molecular dynamics (MD) simulations of the alternating access transition with a recently developed accelerating technique. We successfully obtained a significantly stable IF structure characterized by newly formed well-packed and -organized inter-domain interactions through the accelerated simulations of unprecedentedly large conformational changes of the alternating access without a prior knowledge of the target protein structure. The simulation also shed light on an atomistic mechanism of the strict transport selectivity of adenosine nucleotides over guanosine and inosine ones. Furthermore, the IF structure was shown to bind ATP and BA, and thus revealed their binding mechanisms. The present study proposes a qualitatively novel view of the alternating access of transporters having the unique three-fold symmetry in atomic details and opens the way for rational drug design targeting the transporter in the dynamic functional cycle. PMID:28727843

Structural changes and out-of-sample prediction of realized range-based variance in the stock market

NASA Astrophysics Data System (ADS)

Gong, Xu; Lin, Boqiang

2018-03-01

This paper aims to examine the effects of structural changes on forecasting the realized range-based variance in the stock market. Considering structural changes in variance in the stock market, we develop the HAR-RRV-SC model on the basis of the HAR-RRV model. Subsequently, the HAR-RRV and HAR-RRV-SC models are used to forecast the realized range-based variance of S&P 500 Index. We find that there are many structural changes in variance in the U.S. stock market, and the period after the financial crisis contains more structural change points than the period before the financial crisis. The out-of-sample results show that the HAR-RRV-SC model significantly outperforms the HAR-BV model when they are employed to forecast the 1-day, 1-week, and 1-month realized range-based variances, which means that structural changes can improve out-of-sample prediction of realized range-based variance. The out-of-sample results remain robust across the alternative rolling fixed-window, the alternative threshold value in ICSS algorithm, and the alternative benchmark models. More importantly, we believe that considering structural changes can help improve the out-of-sample performances of most of other existing HAR-RRV-type models in addition to the models used in this paper.

Which Factor, Teaching or Writing, Contributes More to Faculty Development?

ERIC Educational Resources Information Center

Boice, Robert

The effect of a highly-structured faculty development program that focused on improving teaching skills and writing productivity through weekly individual sessions was studied with 16 social sciences faculty. Participants were alternatively assigned to one of four groups that emphasized development in teaching skills, writing productivity, or a…

Intron-mediated alternative splicing of WOOD-ASSOCIATED NAC TRANSCRIPTION FACTOR1B regulates cell wall thickening during fiber development in Populus species.

PubMed

Zhao, Yunjun; Sun, Jiayan; Xu, Peng; Zhang, Rui; Li, Laigeng

2014-02-01

Alternative splicing is an important mechanism involved in regulating the development of multicellular organisms. Although many genes in plants undergo alternative splicing, little is understood of its significance in regulating plant growth and development. In this study, alternative splicing of black cottonwood (Populus trichocarpa) wood-associated NAC domain transcription factor (PtrWNDs), PtrWND1B, is shown to occur exclusively in secondary xylem fiber cells. PtrWND1B is expressed with a normal short-transcript PtrWND1B-s as well as its alternative long-transcript PtrWND1B-l. The intron 2 structure of the PtrWND1B gene was identified as a critical sequence that causes PtrWND1B alternative splicing. Suppression of PtrWND1B expression specifically inhibited fiber cell wall thickening. The two PtrWND1B isoforms play antagonistic roles in regulating cell wall thickening during fiber cell differentiation in Populus spp. PtrWND1B-s overexpression enhanced fiber cell wall thickening, while overexpression of PtrWND1B-l repressed fiber cell wall thickening. Alternative splicing may enable more specific regulation of processes such as fiber cell wall thickening during wood formation.

Intron-Mediated Alternative Splicing of WOOD-ASSOCIATED NAC TRANSCRIPTION FACTOR1B Regulates Cell Wall Thickening during Fiber Development in Populus Species1[W

PubMed Central

Zhao, Yunjun; Sun, Jiayan; Xu, Peng; Zhang, Rui; Li, Laigeng

2014-01-01

Alternative splicing is an important mechanism involved in regulating the development of multicellular organisms. Although many genes in plants undergo alternative splicing, little is understood of its significance in regulating plant growth and development. In this study, alternative splicing of black cottonwood (Populus trichocarpa) wood-associated NAC domain transcription factor (PtrWNDs), PtrWND1B, is shown to occur exclusively in secondary xylem fiber cells. PtrWND1B is expressed with a normal short-transcript PtrWND1B-s as well as its alternative long-transcript PtrWND1B-l. The intron 2 structure of the PtrWND1B gene was identified as a critical sequence that causes PtrWND1B alternative splicing. Suppression of PtrWND1B expression specifically inhibited fiber cell wall thickening. The two PtrWND1B isoforms play antagonistic roles in regulating cell wall thickening during fiber cell differentiation in Populus spp. PtrWND1B-s overexpression enhanced fiber cell wall thickening, while overexpression of PtrWND1B-l repressed fiber cell wall thickening. Alternative splicing may enable more specific regulation of processes such as fiber cell wall thickening during wood formation. PMID:24394777

Using Mixed-Effects Structural Equation Models to Study Student Academic Development.

ERIC Educational Resources Information Center

Pike, Gary R.

1992-01-01

A study at the University of Tennessee Knoxville used mixed-effect structural equation models incorporating latent variables as an alternative to conventional methods of analyzing college students' (n=722) first-year-to-senior academic gains. Results indicate, contrary to previous analysis, that coursework and student characteristics interact to…

Systems definition study for shuttle demonstration flights of large space structures. Volume 3: Thermal analyses

NASA Technical Reports Server (NTRS)

1979-01-01

the development of large space structure technology is discussed. A detailed thermal analysis of a model space fabricated 1 meter beam is presented. Alternative thermal coatings are evaluated, and deflections, stresses, and stiffness variations resulting from flight orientations and solar conditions are predicted.

Development of alternate paragraphs for the Logical Memory subtest of the Wechsler Memory Scale-IV.

PubMed

Morris, Jeri; Swier-Vosnos, Amy; Woodworth, Craig; Umfleet, Laura Glass; Czipri, Sheena; Kopald, Brandon

2014-01-01

The purpose of the two studies included in this article was to validate an alternate form, the Morris Revision-Fourth Edition (MR-IV), to the Logical Memory paragraphs of the Wechsler Memory Scale-Fourth Edition (LM-IV) for use when retesting of individuals is desired. Study I demonstrated high correlation with the LM-IV paragraphs. Study II was a replication that again demonstrated high correlation between the original LM-IV and the new MR-IV paragraphs. High interrater reliability also was demonstrated. Consequently, the MR-IV paragraphs can be considered an alternate form to the LM-IV paragraphs. Although other attempts have been made to develop alternate stories, these new paragraphs are the only ones that are equivalent in structure, affective tone, and number of scorable units. They have considerable clinical utility and research potential.

Implicit and explicit attitudes towards conventional and complementary and alternative medicine treatments: Introduction of an Implicit Association Test.

PubMed

Green, James A; Hohmann, Cynthia; Lister, Kelsi; Albertyn, Riani; Bradshaw, Renee; Johnson, Christine

2016-06-01

This study examined associations between anticipated future health behaviour and participants' attitudes. Three Implicit Association Tests were developed to assess safety, efficacy and overall attitude. They were used to examine preference associations between conventional versus complementary and alternative medicine among 186 participants. A structural equation model suggested only a single implicit association, rather than three separate domains. However, this single implicit association predicted additional variance in anticipated future use of complementary and alternative medicine beyond explicit. Implicit measures should give further insight into motivation for complementary and alternative medicine use. © The Author(s) 2014.

LASER BEAMS: On alternative methods for measuring the radius and propagation ratio of axially symmetric laser beams

NASA Astrophysics Data System (ADS)

Dementjev, Aleksandr S.; Jovaisa, A.; Silko, Galina; Ciegis, Raimondas

2005-11-01

Based on the developed efficient numerical methods for calculating the propagation of light beams, the alternative methods for measuring the beam radius and propagation ratio proposed in the international standard ISO 11146 are analysed. The specific calculations of the alternative beam propagation ratios Mi2 performed for a number of test beams with a complicated spatial structure showed that the correlation coefficients ci used in the international standard do not establish the universal one-to-one relation between the alternative propagation ratios Mi2 and invariant propagation ratios Mσ2 found by the method of moments.

Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing.

PubMed

Castle, John; Garrett-Engele, Phil; Armour, Christopher D; Duenwald, Sven J; Loerch, Patrick M; Meyer, Michael R; Schadt, Eric E; Stoughton, Roland; Parrish, Mark L; Shoemaker, Daniel D; Johnson, Jason M

2003-01-01

Microarrays offer a high-resolution means for monitoring pre-mRNA splicing on a genomic scale. We have developed a novel, unbiased amplification protocol that permits labeling of entire transcripts. Also, hybridization conditions, probe characteristics, and analysis algorithms were optimized for detection of exons, exon-intron edges, and exon junctions. These optimized protocols can be used to detect small variations and isoform mixtures, map the tissue specificity of known human alternative isoforms, and provide a robust, scalable platform for high-throughput discovery of alternative splicing.

Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing

PubMed Central

Castle, John; Garrett-Engele, Phil; Armour, Christopher D; Duenwald, Sven J; Loerch, Patrick M; Meyer, Michael R; Schadt, Eric E; Stoughton, Roland; Parrish, Mark L; Shoemaker, Daniel D; Johnson, Jason M

2003-01-01

Microarrays offer a high-resolution means for monitoring pre-mRNA splicing on a genomic scale. We have developed a novel, unbiased amplification protocol that permits labeling of entire transcripts. Also, hybridization conditions, probe characteristics, and analysis algorithms were optimized for detection of exons, exon-intron edges, and exon junctions. These optimized protocols can be used to detect small variations and isoform mixtures, map the tissue specificity of known human alternative isoforms, and provide a robust, scalable platform for high-throughput discovery of alternative splicing. PMID:14519201

Exploring the Assessment of the DSM-5 Alternative Model for Personality Disorders With the Personality Assessment Inventory.

PubMed

Busch, Alexander J; Morey, Leslie C; Hopwood, Christopher J

2017-01-01

Section III of the Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]; American Psychiatric Association, 2013) contains an alternative model for the diagnosis of personality disorder involving the assessment of 25 traits and a global level of overall personality functioning. There is hope that this model will be increasingly used in clinical and research settings, and the ability to apply established instruments to assess these concepts could facilitate this process. This study sought to develop scoring algorithms for these alternative model concepts using scales from the Personality Assessment Inventory (PAI). A multiple regression strategy used to predict scores in 2 undergraduate samples on DSM-5 alternative model instruments: the Personality Inventory for the DSM-5 (PID-5) and the General Personality Pathology scale (GPP; Morey et al., 2011 ). These regression functions resulted in scores that demonstrated promising convergent and discriminant validity across the alternative model concepts, as well as a factor structure in a cross-validation sample that was congruent with the putative structure of the alternative model traits. Results were linked to the PAI community normative data to provide normative information regarding these alternative model concepts that can be used to identify elevated traits and personality functioning level scores.

A framework for an alternatives assessment dashboard for evaluating chemical alternatives applied to flame retardants for electronic applications

PubMed Central

Martin, Todd M.

2017-01-01

The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are compared using a variety of human health effects, ecotoxicity, and physicochemical properties. Hazard profiles are completed using a variety of online sources and quantitative structure activity relationship models. In the second stage, alternatives are evaluated utilizing an exposure/risk assessment over the entire life cycle. Exposure values are calculated using screening-level near-field and far-field exposure models. The second stage allows one to more accurately compare potential exposure to each alternative and consider additional factors that may not be obvious from separate binned persistence, bioaccumulation, and toxicity scores. The methodology was utilized to compare phosphate-based alternatives for decabromodiphenyl ether (decaBDE) in electronics applications. PMID:29333139

Alternative Shear Panel Configurations for Light Wood Construction. Development, Seismic Performance, and Design Guidance

NASA Astrophysics Data System (ADS)

Wilcoski, James; Fischer, Chad; Allison, Tim; Malach, Kelly Jo

2002-04-01

Shear panels are used in light wood construction to resist lateral loads resulting from earthquakes or strong winds. These panels are typically made of wooden sheathing nailed to building frame members, but this standard panel design interferes with the installation of sheet insulation. A non-insulated shear panel conducts heat between the building interior and exterior wasting considerable amounts of energy. Several alternative shear panel designs were developed to avoid this insulation-mounting problem and sample panels were tested according to standard cyclic test protocols. One of the alternative designs consisted of diagonal steel straps nailed directly to the structural framing. Several others consisted of sheathing nailed to 2 x 4 framing then set into a larger 2 x 6 structural frame in such a way that no sheathing protruded beyond the edge of the 2 x 6 members. Also samples of industry-standard shear panels were constructed and tested in order to establish a performance baseline. Analytical models were developed to size test panels and predict panel behavior. A procedure was developed for establishing design capacities based on both test data and established baseline panel design capacity. The behavior of each panel configuration is documented and recommended design capacities are presented.

Design Optimization of Composite Structures under Uncertainty

NASA Technical Reports Server (NTRS)

Haftka, Raphael T.

2003-01-01

Design optimization under uncertainty is computationally expensive and is also challenging in terms of alternative formulation. The work under the grant focused on developing methods for design against uncertainty that are applicable to composite structural design with emphasis on response surface techniques. Applications included design of stiffened composite plates for improved damage tolerance, the use of response surfaces for fitting weights obtained by structural optimization, and simultaneous design of structure and inspection periods for fail-safe structures.

Structural basis for regulation of GPR56/ADGRG1 by its alternatively spliced extracellular domains

PubMed Central

Salzman, Gabriel S.; Ackerman, Sarah D.; Ding, Chen; Koide, Akiko; Leon, Katherine; Luo, Rong; Stoveken, Hannah M.; Fernandez, Celia G.; Tall, Gregory G.; Piao, Xianhua; Monk, Kelly R.; Koide, Shohei; Araç, Demet

2016-01-01

Summary Adhesion G-protein-coupled receptors (aGPCRs) play critical roles in diverse neurobiological processes including brain development, synaptogenesis, and myelination. aGPCRs have large alternatively spliced extracellular regions (ECRs) that likely mediate intercellular signaling; however, the precise roles of ECRs remain unclear. The aGPCR GPR56/ADGRG1 regulates both oligodendrocyte and cortical development. Accordingly, human GPR56 mutations cause myelination defects and brain malformations. Here, we determined the crystal structure of the GPR56 ECR, the first structure of any complete aGPCR ECR, in complex with an inverse-agonist monobody, revealing a GPCR-Autoproteolysis-Inducing domain and a previously unidentified domain that we term Pentraxin/Laminin/neurexin/sex-hormone-binding-globulin-Like (PLL). Strikingly, PLL domain deletion caused increased signaling and characterizes a GPR56 splice variant. Finally, we show that an evolutionarily conserved residue in the PLL domain is critical for oligodendrocyte development in vivo. Thus, our results suggest that the GPR56 ECR has unique and multifaceted regulatory functions, providing novel insights into aGPCR roles in neurobiology. PMID:27657451

Nominalization and Alternations in Biomedical Language

PubMed Central

Cohen, K. Bretonnel; Palmer, Martha; Hunter, Lawrence

2008-01-01

Background This paper presents data on alternations in the argument structure of common domain-specific verbs and their associated verbal nominalizations in the PennBioIE corpus. Alternation is the term in theoretical linguistics for variations in the surface syntactic form of verbs, e.g. the different forms of stimulate in FSH stimulates follicular development and follicular development is stimulated by FSH. The data is used to assess the implications of alternations for biomedical text mining systems and to test the fit of the sublanguage model to biomedical texts. Methodology/Principal Findings We examined 1,872 tokens of the ten most common domain-specific verbs or their zero-related nouns in the PennBioIE corpus and labelled them for the presence or absence of three alternations. We then annotated the arguments of 746 tokens of the nominalizations related to these verbs and counted alternations related to the presence or absence of arguments and to the syntactic position of non-absent arguments. We found that alternations are quite common both for verbs and for nominalizations. We also found a previously undescribed alternation involving an adjectival present participle. Conclusions/Significance We found that even in this semantically restricted domain, alternations are quite common, and alternations involving nominalizations are exceptionally diverse. Nonetheless, the sublanguage model applies to biomedical language. We also report on a previously undescribed alternation involving an adjectival present participle. PMID:18779866

Theoretical and NMR conformational studies of β-proline oligopeptides with alternating chirality of pyrrolidine units

NASA Astrophysics Data System (ADS)

Mantsyzov, Alexey B.; Savelyev, Oleg Y.; Ivantcova, Polina M.; Bräse, Stefan; Kudryavtsev, Konstantin V.; Polshakov, Vladimir I.

2018-03-01

Synthetic β-peptides are potential functional mimetics of native α-proteins. A recently developed, novel, synthetic approach provides an effective route to the broad group of β-proline oligomers with alternating patterns of stereogenic centers. Conformation of the pyrrolidine ring, Z/E isomerism of β-peptide bonds, and hindered rotation of the neighboring monomers determine the spatial structure of this group of β-proline oligopeptides. Preferences in structural organization and corresponding thermodynamic properties are determined by NMR spectroscopy, restrained molecular dynamics and quantum mechanics. The studied β-proline oligopeptides exist in dimethyl sulfoxide solution in a limited number of conformers, with compatible energy of formation and different spatial organization. In the β-proline tetrapeptide with alternating chirality of composing pyrrolidine units, one of three peptide bonds may exist in an E configuration. For the alternating β-proline pentapeptide, the presence of an E configuration for at least of one β-peptide bond is mandatory. In this case, three peptide bonds synchronously change their configurations. Larger polypeptides may only exist in the presence of several E configurations of β-peptide bonds forming a wave-like extended structure.

Theoretical and NMR Conformational Studies of β-Proline Oligopeptides With Alternating Chirality of Pyrrolidine Units.

PubMed

Mantsyzov, Alexey B; Savelyev, Oleg Y; Ivantcova, Polina M; Bräse, Stefan; Kudryavtsev, Konstantin V; Polshakov, Vladimir I

2018-01-01

Synthetic β-peptides are potential functional mimetics of native α-proteins. A recently developed, novel, synthetic approach provides an effective route to the broad group of β-proline oligomers with alternating patterns of stereogenic centers. Conformation of the pyrrolidine ring, Z / E isomerism of β-peptide bonds, and hindered rotation of the neighboring monomers determine the spatial structure of this group of β-proline oligopeptides. Preferences in their structural organization and corresponding thermodynamic properties are determined by NMR spectroscopy, restrained molecular dynamics and quantum mechanics. The studied β-proline oligopeptides exist in dimethyl sulfoxide solution in a limited number of conformers, with compatible energy of formation and different spatial organization. In the β-proline tetrapeptide with alternating chirality of composing pyrrolidine units, one of three peptide bonds may exist in an E configuration. For the alternating β-proline pentapeptide, the presence of an E configuration for at least of one β-peptide bond is mandatory. In this case, three peptide bonds synchronously change their configurations. Larger polypeptides may only exist in the presence of several E configurations of β-peptide bonds forming a wave-like extended structure.

Revolutionary systems for catalytic combustion and diesel catalytic particulate traps.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stuecker, John Nicholas; Witze, Peter O.; Ferrizz, Robert Matthew

2004-12-01

This report is a summary of an LDRD project completed for the development of materials and structures conducive to advancing the state of the art for catalyst supports and diesel particulate traps. An ancillary development for bio-medical bone scaffolding was also realized. Traditionally, a low-pressure drop catalyst support, such as a ceramic honeycomb monolith, is used for catalytic reactions that require high flow rates of gases at high-temperatures. A drawback to the traditional honeycomb monoliths under these operating conditions is poor mass transfer to the catalyst surface in the straight-through channels. ''Robocasting'' is a unique process developed at Sandia Nationalmore » Laboratories that can be used to manufacture ceramic monoliths with alternative 3-dimensional geometries, providing tortuous pathways to increase mass transfer while maintaining low-pressure drops. These alternative 3-dimensional geometries may also provide a foundation for the development of self-regenerating supports capable of trapping and combusting soot particles from a diesel engine exhaust stream. This report describes the structures developed and characterizes the improved catalytic performance that can result. The results show that, relative to honeycomb monolith supports, considerable improvement in mass transfer efficiency is observed for robocast samples synthesized using an FCC-like geometry of alternating rods. Also, there is clearly a trade-off between enhanced mass transfer and increased pressure drop, which can be optimized depending on the particular demands of a given application. Practical applications include the combustion of natural gas for power generation, production of syngas, and hydrogen reforming reactions. The robocast lattice structures also show practicality for diesel particulate trapping. Preliminary results for trapping efficiency are reported as well as the development of electrically resistive lattices that can regenerate the structure by combusting the trapped soot. During this project an ancillary bio-medical application was discovered for lattices of hydroxyapatite. These structures show promise as bone scaffolds for the reparation of damaged bone. A case study depicting the manufacture of a customized device that fits into a damaged mandible is described.« less

The Structure of Psychopathology in a Community Sample of Preschoolers

ERIC Educational Resources Information Center

Strickland, Jennifer; Keller, Jennifer; Lavigne, John V.; Gouze, Karen; Hopkins, Joyce; LeBailly, Susan

2011-01-01

Despite growing interest in the development of alternative diagnostic classification systems for psychopathology in young children, little is known about the adequacy of the DSM symptom structure for describing psychopathology in this population. This paper examines the fit of the DSM-IV emotional (ED) and disruptive behavior disorder (DD) symptom…

77 FR 49865 - Notice of Availability of an Environmental Impact Statement (EIS) for the San Francisco Veterans...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-17

... parking structure space) of new ambulatory care and research space at a new alternate site in the Mission... Francisco, California. The SFVAMC LRDP involves development and construction of patient care buildings, research buildings, business occupancy buildings, and parking structures, as well as retrofitting...

A Diagnostic Study of Computer Application of Structural Communication Grid

ERIC Educational Resources Information Center

Bahar, Mehmet; Aydin, Fatih; Karakirik, Erol

2009-01-01

In this article, Structural communication grid (SCG), an alternative measurement and evaluation technique, has been firstly summarised and the design, development and implementation of a computer based SCG system have been introduced. The system is then tested on a sample of 154 participants consisting of candidate students, science teachers and…

A Method to Examine Content Domain Structures

ERIC Educational Resources Information Center

D'Agostino, Jerome; Karpinski, Aryn; Welsh, Megan

2011-01-01

After a test is developed, most content validation analyses shift from ascertaining domain definition to studying domain representation and relevance because the domain is assumed to be set once a test exists. We present an approach that allows for the examination of alternative domain structures based on extant test items. In our example based on…

Model fit evaluation in multilevel structural equation models

PubMed Central

Ryu, Ehri

2014-01-01

Assessing goodness of model fit is one of the key questions in structural equation modeling (SEM). Goodness of fit is the extent to which the hypothesized model reproduces the multivariate structure underlying the set of variables. During the earlier development of multilevel structural equation models, the “standard” approach was to evaluate the goodness of fit for the entire model across all levels simultaneously. The model fit statistics produced by the standard approach have a potential problem in detecting lack of fit in the higher-level model for which the effective sample size is much smaller. Also when the standard approach results in poor model fit, it is not clear at which level the model does not fit well. This article reviews two alternative approaches that have been proposed to overcome the limitations of the standard approach. One is a two-step procedure which first produces estimates of saturated covariance matrices at each level and then performs single-level analysis at each level with the estimated covariance matrices as input (Yuan and Bentler, 2007). The other level-specific approach utilizes partially saturated models to obtain test statistics and fit indices for each level separately (Ryu and West, 2009). Simulation studies (e.g., Yuan and Bentler, 2007; Ryu and West, 2009) have consistently shown that both alternative approaches performed well in detecting lack of fit at any level, whereas the standard approach failed to detect lack of fit at the higher level. It is recommended that the alternative approaches are used to assess the model fit in multilevel structural equation model. Advantages and disadvantages of the two alternative approaches are discussed. The alternative approaches are demonstrated in an empirical example. PMID:24550882

Recent developments in structural proteomics for protein structure determination.

PubMed

Liu, Hsuan-Liang; Hsu, Jyh-Ping

2005-05-01

The major challenges in structural proteomics include identifying all the proteins on the genome-wide scale, determining their structure-function relationships, and outlining the precise three-dimensional structures of the proteins. Protein structures are typically determined by experimental approaches such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy. However, the knowledge of three-dimensional space by these techniques is still limited. Thus, computational methods such as comparative and de novo approaches and molecular dynamic simulations are intensively used as alternative tools to predict the three-dimensional structures and dynamic behavior of proteins. This review summarizes recent developments in structural proteomics for protein structure determination; including instrumental methods such as X-ray crystallography and NMR spectroscopy, and computational methods such as comparative and de novo structure prediction and molecular dynamics simulations.

Alternative methods to trench backfill.

DOT National Transportation Integrated Search

2005-04-30

Conduit structures dealing with hydraulic drainage needs in the Louisiana highway system include pipe culverts, pipe arch culverts, storm drains, sewers, etc. Although the Louisiana Department of Transportation and Development (LADOTD) has standard s...

The barriers to clinical coding in general practice: a literature review.

PubMed

de Lusignan, S

2005-06-01

Clinical coding is variable in UK general practice. The reasons for this remain undefined. This review explains why there are no readily available alternatives to recording structured clinical data and reviews the barriers to recording structured clinical data. Methods used included a literature review of bibliographic databases, university health informatics departments, and national and international medical informatics associations. The results show that the current state of development of computers and data processing means there is no practical alternative to coding data. The identified barriers to clinical coding are: the limitations of the coding systems and terminologies and the skill gap in their use; recording structured data in the consultation takes time and is distracting; the level of motivation of primary care professionals; and the priority within the organization. A taxonomy is proposed to describe the barriers to clinical coding. This can be used to identify barriers to coding and facilitate the development of strategies to overcome them.

Syntactic Generalization with Novel Intransitive Verbs

ERIC Educational Resources Information Center

Kline, Melissa; Demuth, Katherine

2014-01-01

To understand how children develop adult argument structure, we must understand the nature of syntactic and semantic representations during development. The present studies compare the performance of children aged 2;6 on the two intransitive alternations in English: patient ("Daddy is cooking the food"/"The food is cooking")…

Investigation of SSME alternate high pressure fuel turbopump lift-off seal fluid and structural dynamic interaction

NASA Technical Reports Server (NTRS)

Elrod, David A.

1989-01-01

The Space Shuttle main engine (SSME) alternate turbopump development program (ATD) high pressure fuel turbopump (HPFTP) design utilizes an innovative lift-off seal (LOS) design that is located in close proximity to the turbine end bearing. Cooling flow exiting the bearing passes through the lift-off seal during steady state operation. The potential for fluid excitation of lift-off seal structural resonances is investigated. No fluid excitation of LOS resonances is predicted. However, if predicted LOS natural frequencies are significantly lowered by the presence of the coolant, pressure oscillations caused by synchronous whirl of the HPFTP rotor may excite a resonance.

Integrated model for assessing the cost and CO2 emission (IMACC) for sustainable structural design in ready-mix concrete.

PubMed

Hong, Taehoon; Ji, Changyoon; Park, Hyoseon

2012-07-30

Cost has traditionally been considered the most important factor in the decision-making process. Recently, along with the consistent interest in environmental problems, environmental impact has also become a key factor. Accordingly, there is a need to develop a method that simultaneously reflects the cost and environmental impact in the decision-making process. This study proposed an integrated model for assessing the cost and CO(2) emission (IMACC) at the same time. IMACC is a model that assesses the cost and CO(2) emission of the various structural-design alternatives proposed in the structural-design process. To develop the IMACC, a standard on assessing the cost and CO(2) emission generated in the construction stage was proposed, along with the CO(2) emission factors in the structural materials, based on such materials' strengths. Moreover, using the economic and environmental scores that signify the cost and CO(2) emission reduction ratios, respectively, a method of selecting the best design alternative was proposed. To verify the applicability of IMACC, practical application was carried out. Structural designs were assessed, each of which used 21, 24, 27, and 30 MPa ready-mix concrete (RMC). The use of IMACC makes it easy to verify what the best design is. Results show the one that used 27 MPa RMC was the best design. Therefore, the proposed IMACC can be used as a tool for supporting the decision-making process in selecting the best design alternative. Copyright © 2012 Elsevier Ltd. All rights reserved.

Dual embedded agency: physicians implement integrative medicine in health-care organizations.

PubMed

Keshet, Yael

2013-11-01

The paradox of embedded agency addresses the question of how embedded agents are able to conceive of new ideas and practices and then implement them in institutionalized organizations if social structures exert so powerful an influence on behavior, and agents operate within a framework of institutional constraints. This article proposes that dual embedded agency may provide an explanation of the paradox. The article draws from an ethnographic study that examined the ways in which dual-trained physicians, namely medical doctors trained also in some modality of complementary and alternative medicine, integrate complementary and alternative medicine into the biomedical fortress of mainstream health-care organizations. Participant observations were conducted during the years 2006-2011. The observed physicians were found to be embedded in two diverse medical cultures and to have a hybrid professional identity that comprised two sets of health-care values. Seeking to introduce new ideas and practices associated with complementary and alternative medicine to medical institutions, they maneuvered among the constraints of institutional structures while using these very structures, in an isomorphic mode of action, as a platform for launching complementary and alternative medicine practices and values. They drew on the complementary and alternative medicine philosophical principle of interconnectedness and interdependency of seemingly polar opposites or contrary forces and acted to achieve change by means of nonadversarial strategies. By addressing the structure-agency dichotomy, this study contributes to the literature on change in institutionalized health-care organizations. It likewise contributes both theoretically and empirically to the study of integrative medicine and to the further development of this relatively new area of inquiry within the sociology of medicine.

Development of a Prototype Decision Support System to Manage the Air Force Alternative Care Program

DTIC Science & Technology

1990-09-01

development model was selected to structure the development process. Since it is necessary to ensure...uncertainty. Furthermore, the SDLC model provides a specific framework "by which an application is conceived, developed , and implemented" (Davis and Olson...associated with the automation of the manual ACP procedures. The SDLC Model has three stages: (1) definition, (2) development , and (3) installation

Past developments and future directions for the AHP in natural resources

Treesearch

Daniel L. Schmoldt; G.A. Mendoza; Jyrki Kangas

2001-01-01

The analytic hierarchy process (AHP) possesses certain characteristics that make it a useful tool for natural resource decision making. The AHP’s capabilities include: participatory decision making, problem structuring and alternative development, group facilitation, consensus building, fairness, qualitative and quantitative information, conflict resolution, decision...

MOAtox: A comprehensive mode of action and acute aquatic toxicity database for predictive model development (SETAC abstract)

EPA Science Inventory

The mode of toxic action (MOA) has been recognized as a key determinant of chemical toxicity and as an alternative to chemical class-based predictive toxicity modeling. However, the development of quantitative structure activity relationship (QSAR) and other models has been limit...

MOAtox: A Comprehensive Mode of Action and Acute Aquatic Toxicity Database for Predictive Model Development

EPA Science Inventory

tThe mode of toxic action (MOA) has been recognized as a key determinant of chemical toxicity andas an alternative to chemical class-based predictive toxicity modeling. However, the development ofquantitative structure activity relationship (QSAR) and other models has been limite...

Developing Resilient Agency in Learning: The Internal Structure of Learning Power

ERIC Educational Resources Information Center

Deakin Crick, Ruth; Huang, Shaofu; Ahmed Shafi, Adeela; Goldspink, Chris

2015-01-01

Understanding students' learning dispositions has been a focus for research in education for many years. A range of alternative approaches to conceptualising and measuring this broad construct have been developed. Traditional psychometric measures aim to produce scales that satisfy the requirements for research; however, such measures have an…

Pyrotechnic shock at the orbiter/external tank forward attachment

NASA Technical Reports Server (NTRS)

Rogers, W. F.; Grissom, D. S.; Rhodes, L. R.

1980-01-01

During the initial certification test of the forward structural attachment of the space shuttle orbiter to the external tank, pyrotechnic shock from actuation of the separation device resulted in structural failure of the thermal protection tiles surrounding the attachment. Because of the high shock associated with the separation bolt, the development of alternative low shock separation designs was initiated. Two concepts that incorporate a 5.08 centimeter frangible nut as the release device were developed and tested.

Talent Development as an Ecology of Games: A Case Study of Norwegian Handball

ERIC Educational Resources Information Center

Bjørndal, Christian Thue; Ronglan, Lars Tore; Andersen, Svein S.

2017-01-01

Structured talent identification and development, it has been argued, is one of the foundations of international sporting success and many modern elite sport systems have applied normative talent development (TD) models. The success of Norwegian handball, however, is based on an alternative approach to TD. Norwegian handball is characterized by a…

Women's labour and economic globalisation: a participatory workshop created by Alternative Women in Development (Alt-WID).

PubMed

Barton, C; Nazombei, E

2000-03-01

This article describes the aims, methods, materials and topics used in a participatory workshop created by Alternative Women in Development. The organization aims to bridge the gaps in analyzing human rights and economic justice in both North and South from a feminist perspective through a workshop. This workshop considers the varied roles that women play in the global economy and features a series of anecdotes to illustrate the diverse ways in which globalization affects women in all regions worldwide. The workshop runs for a minimum of 3 hours and is structured as follows: introduction; plenary: identifying the human rights of the women; small-group work, plenary: building a group analysis and discussion of alternatives to the existing policies; and individual and plenary evaluations. Furthermore, four anecdotes used at the workshop are presented. Among the outcomes of the workshop included the identification of the problem causes and development of strategies for action.

Quantum physics in neuroscience and psychology: A neurophysicalmodel o f mind/brain interaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stapp, Henry P.; Schwartz, Jeffrey M.; Beauregard, Mario

Contemporary physical theory brings directly and irreducibly into the overall causal structure certain psychologically described choices made by human beings about how they will act. This key development in basic physical theory is applicable to neuroscience, and it provides neuroscientists and psychologists with an alternative conceptual structure for describing neural processes.

Rural Economic Development in the 1980s: Preparing for the Future.

ERIC Educational Resources Information Center

Economic Research Service (USDA), Washington, DC. Agriculture and Rural Economics Div.

Seventeen papers review recent changes in the structure and performance of the rural economy and examine alternative policies to facilitate the adjustment of displaced people and their communities. Some point to economic structural change in the 1980s as the cause of financial stress in rural America, in sharp contrast with the 1970s when growth…

Optmization and Fabrication Studies in the Development of Structurally Integrated Thermal Protection System Technology

NASA Technical Reports Server (NTRS)

Stephens, Craig A.

2009-01-01

NASA HYP M&S is pursuing the development of SITPS: 1) Working with HYP MDAO to formulate methodology to incorporate SITPS into hypersonic vehicle design trades. 2) SITPS-0 to SITPS-1 (FY10): a) Manufacturing development and weight reduction (5.8 to 3.1 lb(sub m)/sq ft); b) Structural testing to mature SITPS model. 3) SITPS-2 (FY11): a) Focus on panel closeout, panel-to-panel load transfer, and panel curvature. 4) Extend fabrication technology to include alternate cores and insulations (FY12).

System design analyses of a rotating advanced-technology space station for the year 2025

NASA Technical Reports Server (NTRS)

Queijo, M. J.; Butterfield, A. J.; Cuddihy, W. F.; Stone, R. W.; Wrobel, J. R.; Garn, P. A.; King, C. B.

1988-01-01

Studies of an advanced technology space station configured to implement subsystem technologies projected for availability in the time period 2000 to 2025 is documented. These studies have examined the practical synergies in operational performance available through subsystem technology selection and identified the needs for technology development. Further analyses are performed on power system alternates, momentum management and stabilization, electrothermal propulsion, composite materials and structures, launch vehicle alternates, and lunar and planetary missions. Concluding remarks are made regarding the advanced technology space station concept, its intersubsystem synergies, and its system operational subsystem advanced technology development needs.

Large protein as a potential target for use in rabies diagnostics.

PubMed

Santos Katz, I S; Dias, M H; Lima, I F; Chaves, L B; Ribeiro, O G; Scheffer, K C; Iwai, L K

Rabies is a zoonotic viral disease that remains a serious threat to public health worldwide. The rabies lyssavirus (RABV) genome encodes five structural proteins, multifunctional and significant for pathogenicity. The large protein (L) presents well-conserved genomic regions, which may be a good alternative to generate informative datasets for development of new methods for rabies diagnosis. This paper describes the development of a technique for the identification of L protein in several RABV strains from different hosts, demonstrating that MS-based proteomics is a potential method for antigen identification and a good alternative for rabies diagnosis.

Development, implementation and evaluation of satellite-aided agricultural monitoring systems

NASA Technical Reports Server (NTRS)

Cicone, R. (Principal Investigator); Crist, E.; Metzler, M.; Parris, T.

1982-01-01

Research supporting the use of remote sensing for inventory and assessment of agricultural commodities is summarized. Three task areas are described: (1) corn and soybean crop spectral/temporal signature characterization; (2) efficient area estimation technology development; and (3) advanced satellite and sensor system definition. Studies include an assessment of alternative green measures from MSS variables; the evaluation of alternative methods for identifying, labeling or classification targets in an automobile procedural context; a comparison of MSS, the advanced very high resolution radiometer and the coastal zone color scanner, as well as a critical assessment of thematic mapper dimensionally and spectral structure.

In silico design of supramolecules from their precursors: odd-even effects in cage-forming reactions.

PubMed

Jelfs, Kim E; Eden, Edward G B; Culshaw, Jamie L; Shakespeare, Stephen; Pyzer-Knapp, Edward O; Thompson, Hugh P G; Bacsa, John; Day, Graeme M; Adams, Dave J; Cooper, Andrew I

2013-06-26

We synthesize a series of imine cage molecules where increasing the chain length of the alkanediamine precursor results in an odd-even alternation between [2 + 3] and [4 + 6] cage macrocycles. A computational procedure is developed to predict the thermodynamically preferred product and the lowest energy conformer, hence rationalizing the observed alternation and the 3D cage structures, based on knowledge of the precursors alone.

In silico Design of Supramolecules from Their Precursors: Odd–Even Effects in Cage-Forming Reactions

PubMed Central

2013-01-01

We synthesize a series of imine cage molecules where increasing the chain length of the alkanediamine precursor results in an odd–even alternation between [2 + 3] and [4 + 6] cage macrocycles. A computational procedure is developed to predict the thermodynamically preferred product and the lowest energy conformer, hence rationalizing the observed alternation and the 3D cage structures, based on knowledge of the precursors alone. PMID:23745577

Economic Leverage on the Soviet Union in the 1980s.

DTIC Science & Technology

1984-07-01

structure of the external markets and the Soviet will to resist the foreign pressure and assume the attendant costs. Consideration of the elements making up...additional handi- caps of late development of alternative energy plans, failure to offer alternative markets for the sales of pipe and equipment, and...be left to the dic- tates of the market , but in actuality every government intervenes to shape market flows to some extent. Where purposeful

2016 TSRC Summer School on Fundamental Science for Alternative Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batista, Victor S.

The 2016 TSRC Summer School on Fundamental Science for Alternative Energy introduced principles, methods, and approaches relevant to the design of molecular transformations, energy transduction, and current applications for alternative energy. Energy and environment are likely to be key themes that will dominate the way science and engineering develop over the next few decades. Only an interdisciplinary approach with a team-taught structure as presented at the 2016 TSRC Summer School can be expected to succeed in the face of problems of such difficulty. The course inspired a new generation of 24 graduate students and 2 post-docs to continue work inmore » the field, or at least to have something of an insider's point of view as the field develops in the next few decades.« less

Design of internal support structures for an inflatable lunar habitat

NASA Technical Reports Server (NTRS)

Cameron, Elizabeth A.; Duston, John A.; Lee, David D.

1990-01-01

NASA has a long range goal of constructing a fully equipped, manned lunar outpost on the near side of the moon by the year 2015. The proposed outpost includes an inflatable lunar habitat to support crews during missions longer that 12 months. A design for the internal support structures of the inflatable habitat is presented. The design solution includes material selection, substructure design, assembly plan development, and concept scale model construction. Alternate designs and design solutions for each component of the design are discussed. Alternate materials include aluminum, titanium, and reinforced polymers. Vertical support alternates include column systems, truss systems, suspension systems, and lunar lander supports. Horizontal alternates include beams, trusses, floor/truss systems, and expandable trusses. Feasibility studies on each alternate showed that truss systems and expandable trusses were the most feasible candidates for conceptual design. The team based the designs on the properties of 7075 T73 aluminum. The substructure assembly plan, minimizes assembly time and allows crews to construct the habitat without the use of EVA suits. In addition to the design solutions, the report gives conclusions and recommendations for further study of the inflatable habitat design.

An environmental decision framework applied to marine engine control technologies.

PubMed

Corbett, James J; Chapman, David

2006-06-01

This paper develops a decision framework for considering emission control technologies on marine engines, informed by standard decision theory, with an open structure that may be adapted by operators with specific vessel and technology attributes different from those provided here. Attributes relate objectives important to choosing control technologies with specific alternatives that may meet several of the objectives differently. The transparent framework enables multiple stakeholders to understand how different subjective judgments and varying attribute properties may result in different technology choices. Standard scoring techniques ensure that attributes are not biased by subjective scoring and that weights are the primary quantitative input where subjective preferences are exercised. An expected value decision structure is adopted that considers probabilities (likelihood) that a given alternative can meet its claims; alternative decision criteria are discussed. Capital and annual costs are combined using a net present value approach. An iterative approach is advocated that allows for screening and disqualifying alternatives that do not meet minimum conditions for acceptance, such as engine warranty or U.S. Coast Guard requirements. This decision framework assists vessel operators in considering explicitly important attributes and in representing choices clearly to other stakeholders concerned about reducing air pollution from vessels. This general decision structure may also be applied similarly to other environmental controls in marine applications.

The SIMRAND methodology: Theory and application for the simulation of research and development projects

NASA Technical Reports Server (NTRS)

Miles, R. F., Jr.

1986-01-01

A research and development (R&D) project often involves a number of decisions that must be made concerning which subset of systems or tasks are to be undertaken to achieve the goal of the R&D project. To help in this decision making, SIMRAND (SIMulation of Research ANd Development Projects) is a methodology for the selection of the optimal subset of systems or tasks to be undertaken on an R&D project. Using alternative networks, the SIMRAND methodology models the alternative subsets of systems or tasks under consideration. Each path through an alternative network represents one way of satisfying the project goals. Equations are developed that relate the system or task variables to the measure of reference. Uncertainty is incorporated by treating the variables of the equations probabilistically as random variables, with cumulative distribution functions assessed by technical experts. Analytical techniques of probability theory are used to reduce the complexity of the alternative networks. Cardinal utility functions over the measure of preference are assessed for the decision makers. A run of the SIMRAND Computer I Program combines, in a Monte Carlo simulation model, the network structure, the equations, the cumulative distribution functions, and the utility functions.

Bead-on-string structure printed by electrohydrodynamic jet under alternating current electric field

NASA Astrophysics Data System (ADS)

Liu, Juan; Lin, Yihuang; Jiang, Jiaxin; Liu, Haiyan; Zhao, Yang; Zheng, Gaofeng

2016-09-01

Electrohydrodynamic printing (EHDP) under alternating current (AC) electric field provides a novel way for the precise micro-/nano-droplet printing. The AC electric field induces the free charge to reciprocate along the EHDP jet and changes the electric field force on the jet periodically. The stability of jet can be enhanced by increasing the voltage frequency, and the regular bead-on-string structure is direct-written along the trajectory of collector. The deposition frequency of bead structure increases with the increasing of voltage frequency, due to the short period of AC electric field. As the voltage frequency is increased from 10 to 60 Hz, the diameter of bead structure decreases from 200 to 110 µm. As the duty ration increased from 10 to 60 %, the diameter of bead structure increased from 100 to 140 µm. This work would accelerate the development and the application of micro-/nano-printing technology in the fields of flexible electronic and micro-/nano-system.

Recent Advances in Alternating Current-Driven Organic Light-Emitting Devices.

PubMed

Pan, Yufeng; Xia, Yingdong; Zhang, Haijuan; Qiu, Jian; Zheng, Yiting; Chen, Yonghua; Huang, Wei

2017-11-01

Organic light-emitting devices (OLEDs), typically operated with constant-voltage or direct-current (DC) power sources, are candidates for next-generation solid-state lighting and displays, as they are light, thin, inexpensive, and flexible. However, researchers have focused mainly on the device itself (e.g., development of novel materials, design of the device structure, and optical outcoupling engineering), and little attention has been paid to the driving mode. Recently, an alternative concept to DC-driven OLEDs by directly driving devices using time-dependent voltages or alternating current (AC) has been explored. Here, the effects of different device structures of AC-driven OLEDs, for example, double-insulation, single-insulation, double-injection, and tandem structure, on the device performance are systematically investigated. The formation of excitons and the dielectric layer, which are important to achieve high-performance AC-driven OLEDs, are carefully considered. The importance of gaining further understanding of the fundamental properties of AC-driven OLEDs is then discussed, especially as they relate to device physics. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Object reasoning for waste remediation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pennock, K.A.; Bohn, S.J.; Franklin, A.L.

1991-08-01

A large number of contaminated waste sites across the United States await size remediation efforts. These sites can be physically complex, composed of multiple, possibly interacting, contaminants distributed throughout one or more media. The Remedial Action Assessment System (RAAS) is being designed and developed to support decisions concerning the selection of remediation alternatives. The goal of this system is to broaden the consideration of remediation alternatives, while reducing the time and cost of making these considerations. The Remedial Action Assessment System is a hybrid system, designed and constructed using object-oriented, knowledge- based systems, and structured programming techniques. RAAS uses amore » combination of quantitative and qualitative reasoning to consider and suggest remediation alternatives. The reasoning process that drives this application is centered around an object-oriented organization of remediation technology information. This paper describes the information structure and organization used to support this reasoning process. In addition, the paper describes the level of detail of the technology related information used in RAAS, discusses required assumptions and procedural implications of these assumptions, and provides rationale for structuring RAAS in this manner. 3 refs., 3 figs.« less

In silico methods for co-transcriptional RNA secondary structure prediction and for investigating alternative RNA structure expression.

PubMed

Meyer, Irmtraud M

2017-05-01

RNA transcripts are the primary products of active genes in any living organism, including many viruses. Their cellular destiny not only depends on primary sequence signals, but can also be determined by RNA structure. Recent experimental evidence shows that many transcripts can be assigned more than a single functional RNA structure throughout their cellular life and that structure formation happens co-transcriptionally, i.e. as the transcript is synthesised in the cell. Moreover, functional RNA structures are not limited to non-coding transcripts, but can also feature in coding transcripts. The picture that now emerges is that RNA structures constitute an additional layer of information that can be encoded in any RNA transcript (and on top of other layers of information such as protein-context) in order to exert a wide range of functional roles. Moreover, different encoded RNA structures can be expressed at different stages of a transcript's life in order to alter the transcript's behaviour depending on its actual cellular context. Similar to the concept of alternative splicing for protein-coding genes, where a single transcript can yield different proteins depending on cellular context, it is thus appropriate to propose the notion of alternative RNA structure expression for any given transcript. This review introduces several computational strategies that my group developed to detect different aspects of RNA structure expression in vivo. Two aspects are of particular interest to us: (1) RNA secondary structure features that emerge during co-transcriptional folding and (2) functional RNA structure features that are expressed at different times of a transcript's life and potentially mutually exclusive. Copyright © 2017. Published by Elsevier Inc.

Continuous prestressed concrete girder bridges volume 1 : literature review and preliminary designs.

DOT National Transportation Integrated Search

2012-06-01

The Texas Department of Transportation (TxDOT) is currently designing typical highway bridge structures as simply supported using standard precast, pretensioned girders. TxDOT is interested in developing additional economical design alternatives for ...

Development of improved overlay thickness design alternatives for local roads.

DOT National Transportation Integrated Search

2015-07-01

In this research study, 20 pavement sections were selected from six counties in Illinois, with varying : structural and traffic characteristics. Falling weight deflectometer (FWD) tests were conducted on these : road segments to determine and monitor...

NASA Operational Environment Team (NOET) - NASA's key to environmental technology

NASA Technical Reports Server (NTRS)

Cook, Beth

1993-01-01

NOET is a NASA-wide team which supports the research and development community by sharing information both in person and via a computerized network, assisting in specification and standard revisions, developing cleaner propulsion systems, and exploring environmentally compliant alternatives to current processes. NOET's structure, dissemination of materials, electronic information, EPA compliance, specifications and standards, and environmental research and development are discussed.

Organizational Issues Involved in the Development and Operation of Farm Informational Systems for Modernizing Agriculture.

ERIC Educational Resources Information Center

Lionberger, Herbert F.

The need for an information development system for farmers is discussed in this paper. Issues and alternatives are described in terms of the research-extension-teaching trinity, extension services, role combinations, specialist advisor issues, innovations, research orientation, reward structures, and information services. Information gathered in…

Detailed finite element analysis and preliminary study of the effects of friction and fastener pre-tension on the mechanical behavior of fastened built-up members

NASA Astrophysics Data System (ADS)

Bonachera Martin, Francisco Javier

The characterization of fatigue resistance is one of the main concerns in structural engineering, a concern that is particularly important in the evaluation of existing bridge members designed or erected before the development of fatigue design provisions. The ability of a structural member to develop alternate load paths after the failure of a component is known as member-level or internal redundancy. In fastened built-up members, these alternate load paths are affected by the combination of fastener pre-tension and friction between the structural member components in contact. In this study, a finite element methodology to model and analyze riveted and bolted built-up members was developed in ABAQUS and validated with experimental results. This methodology was used to created finite element models of three fastened plates subjected to tension, in which the middle plate had failed, in order to investigate the fundamental effects of combined fastener pre-tension and friction on their mechanical behavior. Detailed finite element models of riveted and bolted built-up flexural members were created and analyze to understand the effect of fastener pre-tension in member-level redundancy and resistance to fatigue and fracture. The obtained results showed that bolted members are able to re-distribute a larger portion of the load away from the failing component into the rest of the member than riveted members, and that this transfer of load also took place over a smaller length. Superior pre-tension of bolts, in comparison to rivets, results in larger frictional forces that develop at the contact interfaces between components and constitute additional alternate load paths that increase member-level redundancy which increase the fatigue and fracture resistance of the structural member during the failure of one of its components. Although fatigue and fracture potential may be mitigated by compressive stresses developing around the fastener hole due to fastener pre-tension, it was also observed, that at the surface of the fastener hole and at the contact interface with another plate, tensional stresses could develop; however, further computational and experimental work should be performed to verify this claim.

Chicano Alternative Education.

ERIC Educational Resources Information Center

Galicia, H. Homero; Almaguer, Clementina

Alternative schooling is challenging some basic notions of curriculum, operation, and structure of traditional schools; it is not challenging the basic concept of schooling. Chicano alternative education, an elusive concept, lacks a precise definition. Chicano alternative schools reflect a vast diversity in structure, focus, and goals. The Chicano…

The development rubrics skill argued as alternative assessment floating and sinking materials

NASA Astrophysics Data System (ADS)

Viyanti; Cari; Sunarno, Widha; Prasetyo, Zuhdan Kun

2017-11-01

The quality of arguing to learners of floating and sinking material can be assessed by using the rubric of an argumentation assessment skill as an alternative assessment. The quality of the argument is measured by the ability of learners to express the claim in a structured manner in order to maintain the claim with supporting data. The purpose of this study was to develop an argument skill rubric based on the preliminary study results which showed a gap between demands and reality related to the students ‘floating and sinking students’ argument skills. This research was conducted in one of State Senior High School Bandar Lampung. The study population is all students of senior high scholl class XI. Research sample was taken by randomly obtained by 20 students. The research used descriptive survey method. Data were obtained through a multiple choice test both grounded and interview. The results were analyzed based on the level of students’ argumentation skills that had met the criteria which developed in the assessment rubric. The results of the data analysis found that the learners are in the range of levels 1 through 3. Based on the data the average learner is at the level of quality argument “high” for component I and the quality of “low” argument for component 2. This indicates learners experience difficulty which making alternative statement supported by reference in accordance with the initial statement submitted. This fact is supported by interviews that learners need a structured strategy to design alternative statements from shared reading sources to support the preliminary statements presented.

Development of improved pavement rehabilitation procedures based on FWD backcalculation.

DOT National Transportation Integrated Search

2015-01-01

Hot Mix Asphalt (HMA) overlays are among the most effective maintenance and rehabilitation : alternatives in improving the structural as well as functional performance of flexible pavements. HMA : overlay design procedures can be based on: (1) engine...

HEAVY METALS STRUCTURE BENTHIC COMUNITIES IN COLORADO MOUNTAIN STREAMS

EPA Science Inventory

The development of field sampling designs that employ multiple reference and polluted sites has been proposed as an alternative to the traditional upstream vs. downstream approach used in most biomonitoring studies. Spatially extensive monitoring programs can characterize ecologi...

School Finance. Trends and Issues.

ERIC Educational Resources Information Center

Hadderman, Margaret, Comp.

During the past several years, policymakers and practitioners have concentrated their energies on resolving equity/adequacy issues, reforming school tax structures, improving schools' efficiency and cost-effectiveness, developing school-based accountability, and exploring alternative cost-cutting and fundraising strategies. Total expenditures for…

Final Report: Hot Carrier Collection in Thin Film Silicon with Tailored Nanocrystalline/Amorphous Structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, Reuben T.

This project developed, characterized, and perfected a new type of highly tunable nanocrystalline silicon (nc-Si:H) incorporating quantum confined silicon nanoparticles (SiNPs). A dual zone deposition process and system were developed and demonstrated. The depositions of SiNPs, the amorphous phase, and co-deposited material were characterized and optimized. Material design and interpretation of results were guided by new theoretical tools that examined both the electronic structure and carrier dynamics of this hybrid material. Heterojunction and p-i-n solar cells were demonstrated and characterized. Photo-thin-film-transistors allowed mobility to be studied as a function SiNP density in the films. Rapid (hot) transfer of carriers frommore » the amorphous matrix to the quantum confined SiNPs was observed and connected to reduced photo-degradation. The results carry quantum confined Si dots from a novelty to materials that can be harnessed for PV and optoelectronic applications. The growth process is broadly extendable with alternative amorphous matrices, novel layered structures, and alternative NPs easily accessible. The hot carrier effects hold the potential for third generation photovoltaics.« less

A review and evaluation of the internal structure and consistency of the Approaches to Teaching Inventory

NASA Astrophysics Data System (ADS)

Harshman, Jordan; Stains, Marilyne

2017-05-01

This study presents a review from 39 studies that provide evidence for the structural validity and internal consistency of the Approaches to Teaching Inventory (ATI). In addition to this review, we evaluate many alternative factor structures on a sample of 267 first- and second-year chemistry faculty members participating in a professional development, a sample of instructors for which the ATI was originally designed. A total of 26 unique factor structures were evaluated. Through robust checking of assumptions, compilations of existing evidence, and new exploratory and confirmatory analyses, we found that there is greater evidence for the structural validity and internal consistency for the 22-item ATI than the 16-item ATI. Additionally, evidence supporting the original two-factor and four-factor structures proposed by the ATI authors (focusing on information transmission and conceptual change) were not reproducible and while alternative models were empirically viable, more theoretical justification is warranted. Recommendations for ATI use and general comments regarding best practices of reporting psychometrics in educational research contexts are discussed.

First-line managers' experiences of alternative modes of funding in elderly care in Sweden.

PubMed

Antonsson, Helen; Korjonen, Susanne Eriksson; Rosengren, Kristina

2012-09-01

The aim of this study was to describe first-line managers' experiences of alternative modes of funding elderly care in two communities in western Sweden. A growing elderly population demands alternative modes of funding elderly care for better outcomes for patients and better efficiency as it is publicly funded through taxation. The study comprised a total of eight semi-structured interviews with first-line managers working within elderly care. The interviews were analysed using manifest qualitative content analysis. Respect for the individuals was a main concern in the study. One category, quality improvement, and four subcategories freedom of choice, organisational structure, quality awareness and market forces effects were identified to describe first-line managers' experiences of the operation of elderly care. Quality improvement was an important factor to deal with when elderly care was operated in different organisational perspectives, either private or public. The first-line manager is a key person for developing a learning organisation that encourages both staff, clients and their relatives to improve the organisation. Moreover, person-centred care strengthens the client's role in the organisation, which is in line with the government's goal for the quality improvement of elderly care. However, further research is needed on how quality improvement could be developed when different caregivers operate in the same market in order to improve care from the elderly perspective. This study highlights alternative modes of funding elderly care. The economical perspectives should not dominate without taking care of quality improvement when the operation of elderly care is planned and implemented. Strategies such as a learning organisational structure built on person-centred care could create quality improvement in elderly care. © 2012 Blackwell Publishing Ltd.

Multilayer densities using a wavelet-based gravity method and their tectonic implications beneath the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Xu, Chuang; Luo, Zhicai; Sun, Rong; Zhou, Hao; Wu, Yihao

2018-06-01

Determining density structure of the Tibetan Plateau is helpful in better understanding of tectonic structure and development. Seismic method, as traditional approach obtaining a large number of achievements of density structure in the Tibetan Plateau except in the centre and west, is primarily inhibited by the poor seismic station coverage. As the implementation of satellite gravity missions, gravity method is more competitive because of global homogeneous gravity coverage. In this paper, a novel wavelet-based gravity method with high computation efficiency and excellent local identification capability is developed to determine multilayer densities beneath the Tibetan Plateau. The inverted six-layer densities from 0 to 150 km depth can reveal rich tectonic structure and development of study area: (1) The densities present a clockwise pattern, nearly east-west high-low alternating pattern in the west and nearly south-north high-low alternating pattern in the east, which is almost perpendicular to surface movement direction relative to the stable Eurasia from the Global Positioning System velocity field; (2) Apparent fold structure approximately from 10 to 110 km depth can be inferred from the multilayer densities, the deformational direction of which is nearly south-north in the west and east-west in the east; (3) Possible channel flows approximately from 30 to 110 km depth can also be observed clearly during the multilayer densities. Moreover, the inverted multilayer densities are in agreement with previous studies, which verify the correctness and effectiveness of our method.

Multilayer Densities Using a Wavelet-based Gravity Method and Their Tectonic Implications beneath the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Xu, Chuang; Luo, Zhicai; Sun, Rong; Zhou, Hao; Wu, Yihao

2018-03-01

Determining density structure of the Tibetan Plateau is helpful in better understanding tectonic structure and development. Seismic method, as traditional approach obtaining a large number of achievements of density structure in the Tibetan Plateau except in the center and west, is primarily inhibited by the poor seismic station coverage. As the implementation of satellite gravity missions, gravity method is more competitive because of global homogeneous gravity coverage. In this paper, a novel wavelet-based gravity method with high computation efficiency and excellent local identification capability is developed to determine multilayer densities beneath the Tibetan Plateau. The inverted 6-layer densities from 0 km to 150 km depth can reveal rich tectonic structure and development of study area: (1) The densities present a clockwise pattern, nearly east-west high-low alternating pattern in the west and nearly south-north high-low alternating pattern in the east, which is almost perpendicular to surface movement direction relative to the stable Eurasia from the Global Positioning System velocity field; (2) Apparent fold structure approximately from 10 km to 110 km depth can be inferred from the multilayer densities, the deformational direction of which is nearly south-north in the west and east-west in the east; (3) Possible channel flows approximately from 30 km to 110 km depth can be also observed clearly during the multilayer densities. Moreover, the inverted multilayer densities are in agreement with previous studies, which verify the correctness and effectiveness of our method.

Cost-Benefit Analysis For Alternative Low-Emission Surface Preparation/ Depainting Technologies for Structural Steel

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2007-01-01

Stennis Space Center (SSC), Kennedy Space Center (KSC) and Air Force Space Command (AFSPC) identified particulate emissions and waste generated from the depainting process of steel structures as hazardous materials to be eliminated or reduced. A Potential Alternatives Report, Potential Alternatives Report for Validation of Alternative Low Emission Surface Preparation/Depainting Technologies for Structural Steel, provided a technical analyses of identified alternatives to the current coating removal processes, criteria used to select alternatives for further analysis, and a list of those alternatives recommended for testing. The initial coating removal alternatives list was compiled using literature searches and stakeholder recommendations. The involved project participants initially considered approximately 13 alternatives. In late 2003, core project members selected the following depainting processes to be further evaluated: (1) Plastic Blast Media-Quickstrip(R)-A. (2) Hard Abrasive-Steel-Magic(R). (3) Sponge Blasting-Sponge-Jet(R). (4) Liquid Nitrogen-NItroJet(R). (5) Mechanical Removal with Vacuum Attachment-DESCO and OCM Clean-Air (6) Laser Coating Removal Alternatives were tested in accordance with the Joint Test Protocol for Validation of Alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel, and the Field Evaluation Test Plan for Validation of Alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel. Results of the testing are documented in the Joint Test Report. This Cost-Benefit Analysis (CBA) focuses on the three alternatives (Quickstrip(R)-A, SteelMagic (R), and Sponge-Jet(R)) that were considered viable alternatives for large area operations based on the results of the field demonstration and lab testing. This CBA was created to help participants determine if implementation of the candidate alternatives is economically justified. Each of the alternatives examined reduced Environmental Activity (EA) Costs-those costs associated with complying with environmental regulations. One alternative, Steel-Magic(R), also showed reduced Direct Costs and reduced total costs.

AGT 100 automotive gas turbine system development

NASA Technical Reports Server (NTRS)

Helms, H. E. G.

1982-01-01

General Motors is developing an automotive gas turbine system that can be an alternate powerplant for future automobiles. Work sponsored by DOE and administered by NASA Lewis Research Center is emphasizing small component aerodynamics and high-temperature structural ceramics. Reliability requirements of the AGT 100 turbine system include chemical and structural ceramic component stability in the gas turbine environment. The power train system, its configuration and schedule are presented, and its performance tested. The aerodynamic component development is reviewed with discussions on the compressor, turbine, regenerator, interturbine duct and scroll, and combustor. Ceramic component development is also reviewed, and production cost and required capital investment are taken into consideration.

Using structure to explore the sequence alignment space of remote homologs.

PubMed

Kuziemko, Andrew; Honig, Barry; Petrey, Donald

2011-10-01

Protein structure modeling by homology requires an accurate sequence alignment between the query protein and its structural template. However, sequence alignment methods based on dynamic programming (DP) are typically unable to generate accurate alignments for remote sequence homologs, thus limiting the applicability of modeling methods. A central problem is that the alignment that is "optimal" in terms of the DP score does not necessarily correspond to the alignment that produces the most accurate structural model. That is, the correct alignment based on structural superposition will generally have a lower score than the optimal alignment obtained from sequence. Variations of the DP algorithm have been developed that generate alternative alignments that are "suboptimal" in terms of the DP score, but these still encounter difficulties in detecting the correct structural alignment. We present here a new alternative sequence alignment method that relies heavily on the structure of the template. By initially aligning the query sequence to individual fragments in secondary structure elements and combining high-scoring fragments that pass basic tests for "modelability", we can generate accurate alignments within a small ensemble. Our results suggest that the set of sequences that can currently be modeled by homology can be greatly extended.

46 CFR 71.50-3 - Drydock examination, internal structural examination, underwater survey, and alternate hull exam...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., underwater survey, and alternate hull exam intervals. 71.50-3 Section 71.50-3 Shipping COAST GUARD...-3 Drydock examination, internal structural examination, underwater survey, and alternate hull exam... wooden hulls must undergo two drydock and two internal structural examinations within any five year...

On the Concept of "Respiration": Biology Student Teachers' Cognitive Structures and Alternative Conceptions

ERIC Educational Resources Information Center

Kurt, Hakan; Ekici, Gulay; Aktas, Murat; Aksu, Ozlem

2013-01-01

In researches, the subject of respiration has been determined to be among subjects about whom participants from all educational levels struggle to form their cognitive structures and have many alternative conceptions. This research was carried out in order to determine biology student teachers' cognitive structures and alternative conceptions…

The nature and evaluation of commercial expert system building tools, revision 1

NASA Technical Reports Server (NTRS)

Gevarter, William B.

1987-01-01

This memorandum reviews the factors that constitute an Expert System Building Tool (ESBT) and evaluates current tools in terms of these factors. Evaluation of these tools is based on their structure and their alternative forms of knowledge representation, inference mechanisms and developer end-user interfaces. Next, functional capabilities, such as diagnosis and design, are related to alternative forms of mechanization. The characteristics and capabilities of existing commercial tools are then reviewed in terms of these criteria.

Composite casting/bonding construction of an air-cooled, high temperature radial turbine wheel

NASA Technical Reports Server (NTRS)

Hammer, A. N.; Aigret, G.; Rodgers, C.; Metcalfe, A. G.

1983-01-01

A composite casting/bonding technique has been developed for the fabrication of a unique air-cooled, high temperature radial inflow turbine wheel design applicable to auxilliary power units with small rotor diameters and blade entry heights. The 'split blade' manufacturing procedure employed is an alternative to complex internal ceramic coring. Attention is given to both aerothermodynamic and structural design, of which the latter made advantageous use of the exploration of alternative cooling passage configurations through CAD/CAM system software modification.

Method to control residual stress in a film structure and a system thereof

DOEpatents

Parthum, Sr., Michael J.

2008-12-30

A method for controlling residual stress in a structure in a MEMS device and a structure thereof includes selecting a total thickness and an overall equivalent stress for the structure. A thickness for each of at least one set of alternating first and second layers is determined to control an internal stress with respect to a neutral axis for each of the at least alternating first and second layers and to form the structure based on the selected total thickness and the selected overall equivalent stress. Each of the at least alternating first and second layers is deposited to the determined thickness for each of the at least alternating first and second layers to form the structure.

School Finance: A Primer. A Practical Guide to the Structural Components of, Alternative Approaches to, and Policy Questions about State School Finance Systems.

ERIC Educational Resources Information Center

Augenblick, John; And Others

Although school funding structures are similar in many ways across the states, no two states have school finance systems that are precisely the same. School finance systems which are used to achieve multiple objectives, must consider characteristics of numerous school districts, distribute large amounts of money, and have developed incrementally…

What Works in Values Education

ERIC Educational Resources Information Center

Berkowitz, Marvin W.

2011-01-01

Values education (alternatively, moral education, character education) is the attempt, within schools, to craft pedagogies and supportive structures to foster the development of positive, ethical, pro-social inclinations and competencies in youth, including around strengthening their academic focus and achievement. Recent research has uncovered…

Developing short-span alternatives to reinforced concrete box culvert structures in Kansas.

DOT National Transportation Integrated Search

2014-07-01

Concrete box culvert floor slabs are known to have detrimental effects on river and stream hydraulics. : Consequences include an aquatic environment less friendly to the passage of fish and other organisms. This has : prompted environmental regulatio...

The response of pile-guided floats subjected to dynamic loading.

DOT National Transportation Integrated Search

2014-08-01

Pile-Guided floats can be a desirable alternative to stationary berthing structures. Both floats and guide piles are subjected to dynamic : forces such as wind generated waves and impacts from vessels. This project developed a rational basis for esti...

Membrane-lined foundations for liquid thermal storage

NASA Astrophysics Data System (ADS)

Bourne, R. C.

1981-06-01

The membrane lined storage (MLS) container which is a spinoff of vinyl-lined swimming pool and waterbed technologies was developed. The state of development of MLS was evaluated and concepts for MLS structural and heat transfer systems were improved. Preferred structural supports were identified and designed for 1500 gal MLS containers for basement, crawl space, and slab-on-grade foundation types. Techniques are developed to provide space heating via forced air through a finned storage jacket for the two preferred structural enclosure designs. Cost effectiveness of the direct air heating technique is evaluated. Alternate free convection domestic water preheaters and a preferred heat exchanger material is selected. Collector and space heat inlet/outlet designs, design concepts for auxiliary heat input to MLS from resistance electric, combustion, and heat pump sources are developed.

Computer aided flexible envelope designs

NASA Technical Reports Server (NTRS)

Resch, R. D.

1975-01-01

Computer aided design methods are presented for the design and construction of strong, lightweight structures which require complex and precise geometric definition. The first, flexible structures, is a unique system of modeling folded plate structures and space frames. It is possible to continuously vary the geometry of a space frame to produce large, clear spans with curvature. The second method deals with developable surfaces, where both folding and bending are explored with the observed constraint of available building materials, and what minimal distortion result in maximum design capability. Alternative inexpensive fabrication techniques are being developed to achieve computer defined enclosures which are extremely lightweight and mathematically highly precise.

Brayton heat exchanger unit development program (alternate design)

NASA Technical Reports Server (NTRS)

Duncan, J. D.; Gibson, J. C.; Graves, R. F.; Morse, C. J.; Richard, C. E.

1973-01-01

A Brayton Heat Exchanger Unit Alternate Design (BHXU-Alternate) consisting of a recuperator, a heat sink heat exchanger, and a gas ducting system, was designed and fabricated. The design was formulated to provide a high performance unit suitable for use in a long-life Brayton-cycle powerplant. Emphasis was on double containment against external leakage and leakage of the organic coolant into the gas stream. A parametric analysis and design study was performed to establish the optimum component configurations to achieve low weight and size and high reliability, while meeting the requirements of high effectiveness and low pressure drop. Layout studies and detailed mechanical and structural design were performed to obtain a flight-type packaging arrangement, including the close-coupled integration of the BHXU-Alternate with the Brayton Rotating Unit (BRU).

Evaluation of laminar flow control system concepts for subsonic commercial transport aircraft

NASA Technical Reports Server (NTRS)

1980-01-01

A study was conducted to evaluate alternatives in the design of laminar flow control (LFC) subsonic commercial transport aircraft for operation in the 1980's period. Analyses were conducted to select mission parameters and define optimum aircraft configurational parameters for the selected mission, defined by a passenger payload of 400 and a design range of 12,038 km (6500 n mi). The baseline aircraft developed for this mission was used as a vehicle for the evaluation and development of alternative LFC system concepts. Alternatives were evaluated in the areas of aerodynamics structures, materials, LFC systems, leading-edge region cleaning and integration of auxiliary systems. Based on these evaluations, concept in each area were selected for further development and testing and ultimate incorporation in the final study aircraft. Relative to a similarly-optimized advanced technology turbulent transport, the final LFC configuration is approximately equal in direct operating cost but provides decreases of 8.2% in gross weight and 21.7% in fuel consumption.

Semi-active friction damper for buildings subject to seismic excitation

NASA Astrophysics Data System (ADS)

Mantilla, Juan S.; Solarte, Alexander; Gomez, Daniel; Marulanda, Johannio; Thomson, Peter

2016-04-01

Structural control systems are considered an effective alternative for reducing vibrations in civil structures and are classified according to their energy supply requirement: passive, semi-active, active and hybrid. Commonly used structural control systems in buildings are passive friction dampers, which add energy dissipation through damping mechanisms induced by sliding friction between their surfaces. Semi-Active Variable Friction Dampers (SAVFD) allow the optimum efficiency range of friction dampers to be enhanced by controlling the clamping force in real time. This paper describes the development and performance evaluation of a low-cost SAVFD for the reduction of vibrations of structures subject to earthquakes. The SAVFD and a benchmark structural control test structure were experimentally characterized and analytical models were developed and updated based on the dynamic characterization. Decentralized control algorithms were implemented and tested on a shaking table. Relative displacements and accelerations of the structure controlled with the SAVFD were 80% less than those of the uncontrolled structure

Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.

PubMed

Lv, Zongyang; Yuan, Lingmin; Atkison, James H; Aldana-Masangkay, Grace; Chen, Yuan; Olsen, Shaun K

2017-07-21

E1 enzymes for ubiquitin (Ub) and Ub-like modifiers (Ubls) harbor two catalytic activities that are required for Ub/Ubl activation: adenylation and thioester bond formation. Structural studies of the E1 for the Ubl s mall u biquitin-like mo difier (SUMO) revealed a single active site that is transformed by a conformational switch that toggles its competency for catalysis of these two distinct chemical reactions. Although the mechanisms of adenylation and thioester bond formation revealed by SUMO E1 structures are thought to be conserved in Ub E1, there is currently a lack of structural data supporting this hypothesis. Here, we present a structure of Schizosaccharomyces pombe Uba1 in which the second catalytic cysteine half-domain (SCCH domain) harboring the catalytic cysteine has undergone a 106° rotation that results in a completely different network of intramolecular interactions between the SCCH and adenylation domains and translocation of the catalytic cysteine 12 Å closer to the Ub C terminus compared with previous Uba1 structures. SCCH domain alternation is accompanied by conformational changes within the Uba1 adenylation domains that effectively disassemble the adenylation active site. Importantly, the structural and biochemical data suggest that domain alternation and remodeling of the adenylation active site are interconnected and are intrinsic structural features of Uba1 and that the overall structural basis for adenylation and thioester bond formation exhibited by SUMO E1 is indeed conserved in Ub E1. Finally, the mechanistic insights provided by the novel conformational snapshot of Uba1 presented in this study may guide efforts to develop small molecule inhibitors of this critically important enzyme that is an active target for anticancer therapeutics. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

The Paradox of "Structured" Methods for Software Requirements Management: A Case Study of an e-Government Development Project

NASA Astrophysics Data System (ADS)

Conboy, Kieran; Lang, Michael

This chapter outlines the alternative perspectives of "rationalism" and "improvisation" within information systems development and describes the major shortcomings of each. It then discusses how these shortcomings manifested themselves within an e-government case study where a "structured" requirements management method was employed. Although this method was very prescriptive and firmly rooted in the "rational" paradigm, it was observed that users often resorted to improvised behaviour, such as privately making decisions on how certain aspects of the method should or should not be implemented.

A Sliding-Mode Triboelectric Nanogenerator with Chemical Group Grated Structure by Shadow Mask Reactive Ion Etching.

PubMed

Shang, Wanyu; Gu, Guang Qin; Yang, Feng; Zhao, Lei; Cheng, Gang; Du, Zu-Liang; Wang, Zhong Lin

2017-09-26

The sliding-mode triboelectric nanogenerator (S-TENG) with grated structure has important applications in energy harvest and active sensors; however its concavo-convex structure leads to large frictional resistance and abrasion. Here, we developed a S-TENG with a chemical group grated structure (S-TENG-CGG), in which the triboelectric layer's triboelectric potential has a positive-negative alternating charged structure. The triboelectric layer of the S-TENG-CGG was fabricated through a reactive ion etching process with a metal shadow mask with grated structure. In the etched region, the nylon film, originally positively charged as in friction with stainless steel, gained opposite triboelectric potential and became negatively charged because of the change of surface functional groups. The output signals of the S-TENG-CGG are alternating and the frequency is determined by both the segment numbers and the moving speed. The applications of the S-TENG-CGG in the charging capacitor and driving calculator are demonstrated. In the S-TENG-CGG, since there is no concavo-convex structure, the frictional resistance and abrasion are largely reduced, which enhances its performances in better stability and longer working time.

Use of a Garment as an Alternative to Body Painting in Equine Musculoskeletal Anatomy Teaching.

PubMed

Sattin, Mariana M; Silva, Vickitoriana K A; Leandro, Rafael M; Foz Filho, Roberto P P; De Silvio, Mauricio M

Living anatomy is gaining increasing popularity as an alternative to the use of preserved cadaver specimens in musculoskeletal anatomy teaching. This article describes the development of a garment painted with musculoskeletal structures as an alternative to body painting. Garments offer some advantages over traditional body painting in anatomy teaching. The technique can be used across different disciplines, enhances students' ability to identify anatomic structures in living bodies, and provides insights into the topography of one or more body systems at the same time. The fact that garments are amenable to palpation by large groups of students with no damage to the painting favors repeated use in hands-on wet labs. Garments such as the one described in this article introduce a novel approach to interdisciplinary teaching and learning, which can be combined with traditional anatomy teaching methods. The first garment produced depicts part of the equine musculoskeletal system. Steps in garment construction are highlighted and indications, advantages, and limitations of the method discussed.

Developing short-span alternatives to reinforced concrete box culvert structures in Kansas : [technical summary].

DOT National Transportation Integrated Search

2014-07-01

Concrete box culvert floor slabs are known to have detrimental effects on river and stream hydraulics. Consequences include an aquatic environment less friendly to the passage of fish and other organisms. This has prompted environmental regulations r...

Evaluating alterations in Zebrafish retino-tectal projections as an indication of developmental neurotoxicity

EPA Science Inventory

The U.S. EPA is developing alternative screening methods to identify putative developmental neurotoxicants and prioritize chemicals for additional testing. One method developmentally exposes zebrafish embryos and assesses nervous system structure at 2 days post-fertilization (dpf...

Bridge approach slabs for Missouri DOT looking at alternative and cost efficient approaches.

DOT National Transportation Integrated Search

2010-12-01

The objective of this project is to develop innovative and cost effective structural solutions for the construction of : both new and replacement deteriorated Bridge Approach Slabs (BAS). A cost study and email survey was performed to identify : stat...

Transformation of Developmental Neurotoxicity Data into a Structure-Searchable Relational Database

EPA Science Inventory

A database of neurotoxicants is critical to support the development and validation of animal alternatives for neurotoxicity. Validation of in vitro test methods can only be done using known animal and human neurotoxicants producing defined responses for neurochemical, neuropatho...

Education for change in a post-modern world: redefining revolution.

PubMed

Cameron, P; Willis, K; Crack, G

1995-10-01

Social and behavioural sciences are established components in the curriculum of undergraduate nursing degrees. The purpose is to introduce future and practising nurses to the social and political influences which inform their workplaces and practices. Inevitably an awareness of the structural barriers and the powerful political interests involved in health can lead to feelings of powerlessness and despair of achieving change. Yet the skills of critical analysis and political awareness developed in study such as this are essential for health workers in the increasingly complex and politically charged domain in which they work. This paper will explore problems and barriers encountered in development of curriculum and teaching social and behavioural sciences in health. It will propose an alternative conceptual model, based on post-structuralism, as one way of addressing these barriers. This approach shifts the focus from meta-theoretical sociological concepts such as class, gender and culture, to one of examining subject positions, discourse, contestation and local action, thus enabling the exploration and development of possibilities for change. The paper will also provide a case study to illustrate this alternative approach.

A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Webb, Carol F., E-mail: carol-webb@omrf.org; Immunobiology and Cancer Research, Oklahoma Medical Research Foundation, Oklahoma City, OK; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

Despite exciting new possibilities for regenerative therapy posed by the ability to induce pluripotent stem cells, recapitulation of three-dimensional kidneys for repair or replacement has not been possible. ARID3a-deficient mouse tissues generated multipotent, developmentally plastic cells. Therefore, we assessed the adult mouse ARID3a−/− kidney cell line, KKPS5, which expresses renal progenitor surface markers as an alternative cell source for modeling kidney development. Remarkably, these cells spontaneously developed into multicellular nephron-like structures in vitro, and engrafted into immunocompromised medaka mesonephros, where they formed mouse nephron structures. These data implicate KKPS5 cells as a new model system for studying kidney development. - Highlights:more » • An ARID3a-deficient mouse kidney cell line expresses multiple progenitor markers. • This cell line spontaneously forms multiple nephron-like structures in vitro. • This cell line formed mouse kidney structures in immunocompromised medaka fish kidneys. • Our data identify a novel model system for studying kidney development.« less

20 CFR 661.210 - Under what circumstances may the Governor select an alternative entity in place of the State...

Code of Federal Regulations, 2010 CFR

2010-04-01

... the membership structure includes any significant change in the organization of the alternative entity... labor organizations in the State. (c) If the alternative entity does not provide for representative... structure of the alternative entity is significantly changed after December 31, 1997, the entity will no...

Inside-in, alternative paradigms for sound spatialization

NASA Astrophysics Data System (ADS)

Bahn, Curtis; Moore, Stephan

2003-04-01

Arrays of widely spaced mono-directional loudspeakers (P.A.-style stereo configurations or ``outside-in'' surround-sound systems) have long provided the dominant paradigms for electronic sound diffusion. So prevalent are these models that alternatives have largely been ignored and electronic sound, regardless of musical aesthetic, has come to be inseparably associated with single-channel speakers, or headphones. We recognize the value of these familiar paradigms, but believe that electronic sound can and should have many alternative, idiosyncratic voices. Through the design and construction of unique sound diffusion structures, one can reinvent the nature of electronic sound; when allied with new sensor technologies, these structures offer alternative modes of interaction with techniques of sonic computation. This paper describes several recent applications of spherical speakers (multichannel, outward-radiating geodesic speaker arrays) and Sensor-Speaker-Arrays (SenSAs: combinations of various sensor devices with outward-radiating multi-channel speaker arrays). This presentation introduces the development of four generations of spherical speakers-over a hundred individual speakers of various configurations-and their use in many different musical situations including live performance, recording, and sound installation. We describe the design and construction of these systems, and, more generally, the new ``voices'' they give to electronic sound.

Genome structure drives patterns of gene family evolution in ciliates, a case study using Chilodonella uncinata (Protista, Ciliophora, Phyllopharyngea)

PubMed Central

Gao, Feng; Song, Weibo; Katz, Laura A.

2014-01-01

In most lineages, diversity among gene family members results from gene duplication followed by sequence divergence. Because of the genome rearrangements during the development of somatic nuclei, gene family evolution in ciliates involves more complex processes. Previous work on the ciliate Chilodonella uncinata revealed that macronuclear β-tubulin gene family members are generated by alternative processing, in which germline regions are alternatively used in multiple macronuclear chromosomes. To further study genome evolution in this ciliate, we analyzed its transcriptome and found that: 1) alternative processing is extensive among gene families; and 2) such gene families are likely to be C. uncinata-specific. We characterized additional macronuclear and micronuclear copies of one candidate alternatively processed gene family -- a protein kinase domain containing protein (PKc) -- from two C. uncinata strains. Analysis of the PKc sequences reveals: 1) multiple PKc gene family members in the macronucleus share some identical regions flanked by divergent regions; and 2) the shared identical regions are processed from a single micronuclear chromosome. We discuss analogous processes in lineages across the eukaryotic tree of life to provide further insights on the impact of genome structure on gene family evolution in eukaryotes. PMID:24749903

Blast Design of Reinforced Concrete and Masonry Components Retrofitted with FRP

DTIC Science & Technology

2010-07-01

1 BLAST DESIGN OF REINFORCED CONCRETE AND MASONRY COMPONENTS RETROFITTED WITH FRP Marlon L. Bazan, Ph.D. and Charles J. Oswald, P.E., Ph.D...as an alternative to traditional methods for strengthening and retrofitting concrete and masonry structures to resist blast loads. The development...and experimental validation of a methodology for modeling the response of blast loaded concrete and masonry structural components retrofitted with FRP

The development of optimal lightweight truss-core sandwich panels

NASA Astrophysics Data System (ADS)

Langhorst, Benjamin Robert

Sandwich structures effectively provide lightweight stiffness and strength by sandwiching a low-density core between stiff face sheets. The performance of lightweight truss-core sandwich panels is enhanced through the design of novel truss arrangements and the development of methods by which the panels may be optimized. An introduction to sandwich panels is presented along with an overview of previous research of truss-core sandwich panels. Three alternative truss arrangements are developed and their corresponding advantages, disadvantages, and optimization routines are discussed. Finally, performance is investigated by theoretical and numerical methods, and it is shown that the relative structural efficiency of alternative truss cores varies with panel weight and load-carrying capacity. Discrete truss core sandwich panels can be designed to serve bending applications more efficiently than traditional pyramidal truss arrangements at low panel weights and load capacities. Additionally, discrete-truss cores permit the design of heterogeneous cores, which feature unit cells that vary in geometry throughout the panel according to the internal loads present at each unit cell's location. A discrete-truss core panel may be selectively strengthened to more efficiently support bending loads. Future research is proposed and additional areas for lightweight sandwich panel development are explained.

Matrix Management: An Organizational Alternative for Libraries.

ERIC Educational Resources Information Center

Johnson, Peggy

1990-01-01

Describes various organizational structures and models, presents matrix management as an alternative to traditional hierarchical structures, and suggests matrix management as an appropriate organizational alternative for academic libraries. Benefits that are discussed include increased flexibility, a higher level of professional independence, and…

A survey of surface structures and subsurface developments for lunar bases

NASA Technical Reports Server (NTRS)

Hypes, Warren D.; Wright, Robert L.

1990-01-01

Concepts proposed for lunar-base structures and shelters include those fabricated on earth, fabricated locally using lunar materials, and developed from subsurface features. Early bases may rely on evolutionary growth using Space Station modules and nodes covered with regolith for protection against thermal and radiative stresses. Expandable/inflatable shelters used alone on the surface or in conjunction with subselene (beneath the lunar surface) features and spent portions of the Space Shuttle's fuel tanks offer early alternatives. More mature lunar bases may need larger volumes provided by erectable buildings, hybrid inflatable/rigid spheres, modular concrete buildings using locally derived cement, or larger subselene developments.

Techniques for assessing the socio-economic effects of vehicle mileage fees.

DOT National Transportation Integrated Search

2008-06-01

The purpose of this study was to develop tools for assessing the distributional effects of alternative highway user fees for light vehicles : in Oregon. The analysis focused on a change from the current gasoline tax to a VMT fee structure for collect...

Chameleons in Marketspace: Industry Transformation in the New Electronic Marketing Environment.

ERIC Educational Resources Information Center

Pattinson, Hugh; Brown, Linden

1996-01-01

Discusses the new information infrastructure and its possible influences on marketing. Highlights include an alternative perspective of industrial economic history based on infrastructure development; the Internet and its positioning within the new information infrastructure; future possibilities and impacts on organizational structure; and…

The response of pile-guided floats subjected to dynamic loading : volume I final report.

DOT National Transportation Integrated Search

2014-08-01

Pile : - : Guided floats can be a desirable alternative to stationary berthing structures. Both floats and guide piles are subjected to dynamic : forces such as wind generated waves and impacts from vessels. This project developed a rational basis fo...

The response of pile-guided floats subjected to dynamic loading : volume II annex.

DOT National Transportation Integrated Search

2014-08-01

Pile-Guided floats can be a desirable alternative to stationary berthing structures. Both floats and guide piles are subjected to dynamic : forces such as wind generated waves and impacts from vessels. This project developed a rational basis for esti...

Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue.

PubMed

Wessels, Quenton; Pretorius, Etheresia

2015-08-01

Burn wound care today has a primary objective of temporary or permanent wound closure. Commercially available engineered alternative tissues have become a valuable adjunct to the treatment of burn injuries. Their constituents can be biological, alloplastic or a combination of both. Here the authors describe the aspects of the development of a siloxane epidermis for a collagen-glycosaminoglycan and for nylon-based artificial skin replacement products. A method to fabricate an ultra-thin epidermal equivalent is described. Pores, to allow the escape of wound exudate, were punched and a tri-filament nylon mesh or collagen scaffold was imbedded and silicone polymerisation followed at 120°C for 5 minutes. The ultra-structure of these bilaminates was assessed through scanning electron microscopy. An ultra-thin biomedical grade siloxane film was reliably created through precision coating on a pre-treated polyethylene terephthalate carrier. © 2013 The Authors. International Wound Journal © 2013 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Can an Analysis of the Contrast Between pre-Galilean and Newtonian Theoretical Frameworks Help Students Develop a Scientific Mindset

NASA Astrophysics Data System (ADS)

Kalman, Calvin S.; Aulls, Mark W.

This study examines a course in which students use two writing activities and collaborative group activities to examine the conceptual structure of the calculus-based introductory Physics course. Students are presented with two alternative frameworks; pre-Galilean Physics and Newtonian Physics. The idea of the course design is that students would at first view the frameworks almost in a theatrical sense as a view of a drama involving a conflict of actors;Aristotle, Galileo, Newton and others occurring a long time ago. As participants passing through a series of interventions, the students become aware that the frameworks relate concepts from different parts of the course and learn to evaluate the two alternative frameworks. They develop a scientific mindset changing their outlook on the course material from the viewpoint that it consists of a tool kit of assorted practices, classified according to problem type, to the viewpoint that it comprises a connected structure of concepts.

Alternatives to Dam Building: Deindustrialization and the Redevelopment of Waterways in the Northeast During the Twentieth Century

NASA Astrophysics Data System (ADS)

Taber, J. S.; Pompeii, B. J.; Nicoletti, C.; Lopez-Morales, C. A.

2010-12-01

The Northeast United States contains more dams than any other region in the country but it lacks structures on the scale of the Hoover or Bonneville dams in the American West. This work addresses why the Northeast lacks such large dams and how the pattern of small dams within the region shaped its social development. During the twentieth century, changing social and economic conditions rendered the initial purposes of many dams in the region moot, but these structures continued to influence hydrologic conditions and the provision of ecosystem services to an expanding population. The continued existence of many of these dams resulted from a worldview unable to conceive of dam removal as it did to the economic or environmental services provided by the structure. Documenting the process by which society developed alternatives to dam building in this region can contextualize the origins and contingent character of ideas about dam removal. The overarching theme in this process is the deindustrialization of the Northeast, which pitted the interests of industrial cities undergoing economic reorganization, emerging suburban communities, and growing service industries in the region. This paper considers changing attitudes toward dams as part of a four step process: (1) although the mill dams of the industrial revolution remained after electrification rendered manufacturers independent of direct water power in the early twentieth century, deindustrialization reshaped the political and legal responses to flooding by stregnthening the political and economic position of service industries and suburban residential interests; (2) the most tangible response to this development was proposed federal investment in dam building in the region between the 1930s and the 1950s; (3) political conflicts between local interests and federal proposals for dam construction slowed down the dam building process and enabled people to consider alternative strategies for flood control and power generation; and (4) these alternatives included conservation measures such as the preservation of wetlands, but they also included the construction of coal and nuclear power plants in place of hydroelectric dams. Documenting the complexities underlying dam building and its alternatives in a deindustrializing region saddled with obsolete dams can contextualize contemporary debates regarding the maintenance or removal of old dams.

In-situ and Ex-situ Observations of Lithium De-intercalation from LiCoO2: Atomic Force Microscopy and Transmission Electron Microscopy Studies

DTIC Science & Technology

2005-06-01

has a layered structure consisting of lithium and cobalt sheets stacked alternatively between oxygen sheets. Li and Co occupy octahedral sites in...cobalt sheets stacked alternatively between ABCABC close-packed oxygen arrays. Li and Co occupy octahedral sites in alternating layers between the oxygen... Co 4.- o 4 Li Figure 1: Crystal structure of LiCoO2. LiCoO2 has a layered structure consisting of lithium and cobalt sheets stacked alternatively

Technology transfer and international development: Materials and manufacturing technology

NASA Technical Reports Server (NTRS)

1982-01-01

Policy oriented studies on technological development in several relatively advanced developing countries were conducted. Priority sectors defined in terms of technological sophistication, capital intensity, value added, and export potential were studied in Brazil, Venezuela, Israel, and Korea. The development of technological policy alternatives for the sponsoring country is assessed. Much emphasis is placed on understanding the dynamics of the sectors through structured interviews with a large sample of firms in the leading manufacturing and materials processing sectors.

Surface texture and hardness of dental alloys processed by alternative technologies

NASA Astrophysics Data System (ADS)

Porojan, Liliana; Savencu, Cristina E.; Topală, Florin I.; Porojan, Sorin D.

2017-08-01

Technological developments have led to the implementation of novel digitalized manufacturing methods for the production of metallic structures in prosthetic dentistry. These technologies can be classified as based on subtractive manufacturing, assisted by computer-aided design/computer-aided manufacturing (CAD/CAM) systems, or on additive manufacturing (AM), such as the recently developed laser-based methods. The aim of the study was to assess the surface texture and hardness of metallic structures for dental restorations obtained by alternative technologies: conventional casting (CST), computerized milling (MIL), AM power bed fusion methods, respective selective laser melting (SLM) and selective laser sintering (SLS). For the experimental analyses metallic specimens made of Co-Cr dental alloys were prepared as indicated by the manufacturers. The specimen structure at the macro level was observed by an optical microscope and micro-hardness was measured in all substrates. Metallic frameworks obtained by AM are characterized by increased hardness, depending also on the surface processing. The formation of microstructural defects can be better controlled and avoided during SLM and MIL process. Application of power bed fusion techniques, like SLS and SLM, is currently a challenge in dental alloys processing.

Self-assembled biomimetic nanoreactors I: Polymeric template

NASA Astrophysics Data System (ADS)

McTaggart, Matt; Malardier-Jugroot, Cecile; Jugroot, Manish

2015-09-01

The variety of nanoarchitectures made feasible by the self-assembly of alternating copolymers opens new avenues for biomimicry. Indeed, self-assembled structures allow the development of nanoreactors which combine the efficiency of high surface area metal active centres to the effect of confinement due to the very small cavities generated by the self-assembly process. A novel self-assembly of high molecular weight alternating copolymers is characterized in the present study. The self-assembly is shown to organize into nanosheets, providing a 2 nm hydrophobic cavity with a 1D confinement.

Synthesis and x-ray characterization of cobalt phosphide (Co₂P) nanorods for the oxygen reduction reaction

DOE PAGES

Doan-Nguyen, Vicky V.T.; Su, Dong; Zhang, Sen; ...

2015-07-14

Low temperature fuel cells are clean, effective alternative fuel conversion technology. Oxygen reduction reaction (ORR) at the fuel cell cathode has required Pt as the electrocatalyst for high activity and selectivity of the four-electron reaction pathway. Targeting a less expensive, earth abundant alternative, we have developed the synthesis of cobalt phosphide (Co₂P) nanorods for ORR. Characterization techniques that include total X-ray scattering and extended X-ray absorption fine structure revealed a deviation of the nanorods from bulk crystal structure with a contraction along the b orthorhombic lattice parameter. The carbon supported nanorods have comparable activity but are remarkably more stable thanmore » conventional Pt catalysts for the oxygen reduction reaction in alkaline environments.« less

Structural dynamics verification facility study

NASA Technical Reports Server (NTRS)

Kiraly, L. J.; Hirchbein, M. S.; Mcaleese, J. M.; Fleming, D. P.

1981-01-01

The need for a structural dynamics verification facility to support structures programs was studied. Most of the industry operated facilities are used for highly focused research, component development, and problem solving, and are not used for the generic understanding of the coupled dynamic response of major engine subsystems. Capabilities for the proposed facility include: the ability to both excite and measure coupled structural dynamic response of elastic blades on elastic shafting, the mechanical simulation of various dynamical loadings representative of those seen in operating engines, and the measurement of engine dynamic deflections and interface forces caused by alternative engine mounting configurations and compliances.

Differential expression and alternative splicing of rice sulphate transporter family members regulate sulphur status during plant growth, development and stress conditions.

PubMed

Kumar, Smita; Asif, Mehar Hasan; Chakrabarty, Debasis; Tripathi, Rudra Deo; Trivedi, Prabodh Kumar

2011-06-01

Sulphur, an essential nutrient required for plant growth and development, is mainly taken up by the plants as inorganic sulphate from the soil and assimilated into the sulphur reductive pathway. The uptake and transport of sulphate in plants is carried out by transporters encoded by the sulphate transporter gene family. Plant sulphate transporters have been classified with respect to their protein sequences, kinetic properties and tissue-specific localization in Arabidopsis. Though sulphate transporter genes from few other plants have also been characterized, no detailed study with respect to the structure and expression of this family from rice has been carried out. Here, we present genome-wide identification, structural and expression analyses of the rice sulphate transporter gene family. Our analysis using microarray data and MPSS database suggests that 14 rice sulphate transporters are differentially expressed during growth and development in various tissues and during biotic and abiotic stresses. Our analysis also suggests differential accumulation of splice variants of OsSultr1;1 and OsSultr4;1 transcripts during these processes. Apart from known spliced variants, we report an unusual alternative splicing of OsSultr1;1 transcript related to sulphur supply in growth medium and during stress response. Taken together, our study suggests that differential expression and alternative splicing of members of the sulphate transporter family plays an important role in regulating cellular sulphur status required for growth and development and during stress conditions. These findings significantly advance our understanding of the posttranscriptional regulatory mechanisms operating to regulate sulphur demand by the plant.

Evaluation of the hypersensitivity potential of alternative butter flavorings

PubMed Central

Anderson, Stacey E.; Franko, Jennifer; Wells, J.R.; Lukomska, Ewa; Meade, B. Jean

2015-01-01

Concern has been raised over the association of diacetyl with lung disease clinically resembling bronchiolitis obliterans in food manufacturing workers. This has resulted in the need for identification of alternative chemicals to be used in the manufacturing process. Structurally similar chemicals, 2,3-pentanedione, 2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione, used as constituents of synthetic flavoring agents have been suggested as potential alternatives for diacetyl, however, immunotoxicity data on these chemicals are limited. The present study evaluated the dermal irritation and sensitization potential of diacetyl alternatives using a murine model. None of the chemicals were identified as dermal irritants when tested at concentrations up to 50%. Similar to diacetyl (EC3 = 17.9%), concentration-dependent increases in lymphocyte proliferation were observed following exposure to all four chemicals, with calculated EC3 values of 15.4% (2,3-pentanedione), 18.2% (2,3-hexanedione), 15.5% (3,4-hexanedione) and 14.1% (2,3-heptanedione). No biologically significant elevations in local or total serum IgE were identified after exposure to 25–50% concentrations of these chemicals. These results demonstrate the potential for development of hypersensitivity responses to these proposed alternative butter flavorings and raise concern about the use of structurally similar replacement chemicals. Additionally, a contaminant with strong sensitization potential was found in varying concentrations in diacetyl obtained from different producers. PMID:24007741

Evaluation of the hypersensitivity potential of alternative butter flavorings.

PubMed

Anderson, Stacey E; Franko, Jennifer; Wells, J R; Lukomska, Ewa; Meade, B Jean

2013-12-01

Concern has been raised over the association of diacetyl with lung disease clinically resembling bronchiolitis obliterans in food manufacturing workers. This has resulted in the need for identification of alternative chemicals to be used in the manufacturing process. Structurally similar chemicals, 2,3-pentanedione, 2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione, used as constituents of synthetic flavoring agents have been suggested as potential alternatives for diacetyl, however, immunotoxicity data on these chemicals are limited. The present study evaluated the dermal irritation and sensitization potential of diacetyl alternatives using a murine model. None of the chemicals were identified as dermal irritants when tested at concentrations up to 50%. Similar to diacetyl (EC3=17.9%), concentration-dependent increases in lymphocyte proliferation were observed following exposure to all four chemicals, with calculated EC3 values of 15.4% (2,3-pentanedione), 18.2% (2,3-hexanedione), 15.5% (3,4-hexanedione) and 14.1% (2,3-heptanedione). No biologically significant elevations in local or total serum IgE were identified after exposure to 25-50% concentrations of these chemicals. These results demonstrate the potential for development of hypersensitivity responses to these proposed alternative butter flavorings and raise concern about the use of structurally similar replacement chemicals. Additionally, a contaminant with strong sensitization potential was found in varying concentrations in diacetyl obtained from different producers. Published by Elsevier Ltd.

Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure

PubMed Central

Shen, Manli; Bellaousov, Stanislav; Hiller, Michael; de La Grange, Pierre; Creamer, Trevor P.; Malina, Orit; Sperling, Ruth; Mathews, David H.; Stoilov, Peter; Stamm, Stefan

2013-01-01

The serotonin receptor 2C plays a central role in mood and appetite control. It undergoes pre-mRNA editing as well as alternative splicing. The RNA editing suggests that the pre-mRNA forms a stable secondary structure in vivo. To identify substances that promote alternative exons inclusion, we set up a high-throughput screen and identified pyrvinium pamoate as a drug-promoting exon inclusion without editing. Circular dichroism spectroscopy indicates that pyrvinium pamoate binds directly to the pre-mRNA and changes its structure. SHAPE (selective 2′-hydroxyl acylation analysed by primer extension) assays show that part of the regulated 5′-splice site forms intramolecular base pairs that are removed by this structural change, which likely allows splice site recognition and exon inclusion. Genome-wide analyses show that pyrvinium pamoate regulates >300 alternative exons that form secondary structures enriched in A–U base pairs. Our data demonstrate that alternative splicing of structured pre-mRNAs can be regulated by small molecules that directly bind to the RNA, which is reminiscent to an RNA riboswitch. PMID:23393189

Diagnosing Students’ conception on atomic structure using open ended questions

NASA Astrophysics Data System (ADS)

Fitriza, Z.; Gazali, F.

2018-05-01

This study aims to diagnose students’ conception on atomic structure concepts using open ended questions. For this reason, a 7 items of assay test was administered to 135 senior high school students from different schools in West Sumatera. The data were collected using a an open ended test which is covering the concept used in the topic Atomic Structure. The open ended test of students’ conceptual was developed to identify the alternative conceptions that student might have regarding the concepts in Atomic Structure, to measure the level of students’ conceptions, and the way of students’ thinking concerning the concepts. The results showed that students find difficulties about some concepts of Atomic structure such as atom, atomic model, electron configuration, period and group.The result of this study illuminated the concepts to be underlined in developing teaching and learning approach concerning the topic of Atomic Structure.

24 CFR 941.203 - Design and construction standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... with children shall consist to the maximum extent practicable of low-density housing (e.g., non-elevator structures, scattered sites or other types of low-density developments appropriate in the... density, unless the PHA demonstrates and HUD determines that there is no practical alternative. High-rise...

Orbital Battleship: A Guessing Game to Reinforce Atomic Structure

ERIC Educational Resources Information Center

Kurushkin, Mikhail; Mikhaylenko, Maria

2016-01-01

A competitive educational guessing game "Orbital Battleship" which reinforces Madelung's and Hund's rules, values of quantum numbers, and understanding of periodicity was designed. The game develops strategic thinking, is not time-consuming, requires minimal preparation and supervision, and is an efficient and fun alternative to more…

Impact of Technological and Structural Change on Employment. Prospective Analysis 2020. Synthesis Report. Report to the Committee on Employment and Social Affairs of the European Parliament. Technical Report Series.

ERIC Educational Resources Information Center

2001

The possible impact of technological and structural change on employment in the European Union (EU) over the next 20 years was examined through an exploration of the following alternative policy-driven scenarios: (1) business as usual; (2) concentrated technology policy (increases in innovation and research and development [R&D] efforts are…

Multilevel modelling: Beyond the basic applications.

PubMed

Wright, Daniel B; London, Kamala

2009-05-01

Over the last 30 years statistical algorithms have been developed to analyse datasets that have a hierarchical/multilevel structure. Particularly within developmental and educational psychology these techniques have become common where the sample has an obvious hierarchical structure, like pupils nested within a classroom. We describe two areas beyond the basic applications of multilevel modelling that are important to psychology: modelling the covariance structure in longitudinal designs and using generalized linear multilevel modelling as an alternative to methods from signal detection theory (SDT). Detailed code for all analyses is described using packages for the freeware R.

Rocket nozzle thermal shock tests in an arc heater facility

NASA Technical Reports Server (NTRS)

Painter, James H.; Williamson, Ronald A.

1986-01-01

A rocket motor nozzle thermal structural test technique that utilizes arc heated nitrogen to simulate a motor burn was developed. The technique was used to test four heavily instrumented full-scale Star 48 rocket motor 2D carbon/carbon segments at conditions simulating the predicted thermal-structural environment. All four nozzles survived the tests without catastrophic or other structural failures. The test technique demonstrated promise as a low cost, controllable alternative to rocket motor firing. The technique includes the capability of rapid termination in the event of failure, allowing post-test analysis.

Technical Review of the CENWP Computational Fluid Dynamics Model of the John Day Dam Forebay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rakowski, Cynthia L.; Serkowski, John A.; Richmond, Marshall C.

The US Army Corps of Engineers Portland District (CENWP) has developed a computational fluid dynamics (CFD) model of the John Day forebay on the Columbia River to aid in the development and design of alternatives to improve juvenile salmon passage at the John Day Project. At the request of CENWP, Pacific Northwest National Laboratory (PNNL) Hydrology Group has conducted a technical review of CENWP's CFD model run in CFD solver software, STAR-CD. PNNL has extensive experience developing and applying 3D CFD models run in STAR-CD for Columbia River hydroelectric projects. The John Day forebay model developed by CENWP is adequatelymore » configured and validated. The model is ready for use simulating forebay hydraulics for structural and operational alternatives. The approach and method are sound, however CENWP has identified some improvements that need to be made for future models and for modifications to this existing model.« less

46 CFR 177.340 - Alternate design considerations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Alternate design considerations. 177.340 Section 177.340... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed or...

Home health nursing care agenda based on health policy in Korea.

PubMed

Ryu, Hosihn; An, Jiyoung; Koabyashi, Mia

2005-06-01

Home health nursing care (HHNC) in Korea has taken on an important role under the mandate of the national health care system since 2000. This program was developed to verify the possibility of early discharge of hospitalized patients and cost containment through a research and development project that was conducted with the government from 1994 to 1999. The process of development of HHNC provided an opportunity to realize the advancement and changes in the system into a consumer-focused structure. This is an important turning point for the Korean health care system that suggests certain possibilities for building a foundation for further changes in the service delivery structure. The structure, which had been limited to a supplier-oriented model, is moving to a consumer-oriented structure. Accordingly, the major function and role of nursing policy makers in Korea is to develop an agenda and alternatives for policy-making in a systematic manner and to present implementation strategies clearly.

Development of an embedded thin-film strain-gauge-based SHM network into 3D-woven composite structure for wind turbine blades

NASA Astrophysics Data System (ADS)

Zhao, Dongning; Rasool, Shafqat; Forde, Micheal; Weafer, Bryan; Archer, Edward; McIlhagger, Alistair; McLaughlin, James

2017-04-01

Recently, there has been increasing demand in developing low-cost, effective structure health monitoring system to be embedded into 3D-woven composite wind turbine blades to determine structural integrity and presence of defects. With measuring the strain and temperature inside composites at both in-situ blade resin curing and in-service stages, we are developing a novel scheme to embed a resistive-strain-based thin-metal-film sensory into the blade spar-cap that is made of composite laminates to determine structural integrity and presence of defects. Thus, with fiberglass, epoxy, and a thinmetal- film sensing element, a three-part, low-cost, smart composite laminate is developed. Embedded strain sensory inside composite laminate prototype survived after laminate curing process. The internal strain reading from embedded strain sensor under three-point-bending test standard is comparable. It proves that our proposed method will provide another SHM alternative to reduce sensing costs during the renewable green energy generation.

Role of Kekulé and Non-Kekulé Structures in the Radical Character of Alternant Polycyclic Aromatic Hydrocarbons: A TAO-DFT Study

PubMed Central

Yeh, Chia-Nan; Chai, Jeng-Da

2016-01-01

We investigate the role of Kekulé and non-Kekulé structures in the radical character of alternant polycyclic aromatic hydrocarbons (PAHs) using thermally-assisted-occupation density functional theory (TAO-DFT), an efficient electronic structure method for the study of large ground-state systems with strong static correlation effects. Our results reveal that the studies of Kekulé and non-Kekulé structures qualitatively describe the radical character of alternant PAHs, which could be useful when electronic structure calculations are infeasible due to the expensive computational cost. In addition, our results support previous findings on the increase in radical character with increasing system size. For alternant PAHs with the same number of aromatic rings, the geometrical arrangements of aromatic rings are responsible for their radical character. PMID:27457289

Permeability study of cancellous bone and its idealised structures.

PubMed

Syahrom, Ardiyansyah; Abdul Kadir, Mohammed Rafiq; Harun, Muhamad Nor; Öchsner, Andreas

2015-01-01

Artificial bone is a suitable alternative to autografts and allografts, however their use is still limited. Though there were numerous reports on their structural properties, permeability studies of artificial bones were comparably scarce. This study focused on the development of idealised, structured models of artificial cancellous bone and compared their permeability values with bone surface area and porosity. Cancellous bones from fresh bovine femur were extracted and cleaned following an established protocol. The samples were scanned using micro-computed tomography (μCT) and three-dimensional models of the cancellous bones were reconstructed for morphology study. Seven idealised and structured cancellous bone models were then developed and fabricated via rapid prototyping technique. A test-rig was developed and permeability tests were performed on the artificial and real cancellous bones. The results showed a linear correlation between the permeability and the porosity as well as the bone surface area. The plate-like idealised structure showed a similar value of permeability to the real cancellous bones. Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.

Alternative Models for the ERIC Clearinghouse Network.

ERIC Educational Resources Information Center

Greenwood, P. W.; Weiler, D. M.

The National Center for Educational Communication (NCEC) contracted with Rand to develop a range of potential objectives and structures for the Educational Resources Information Center (ERIC) system that could render it more effective in the future. The Rand study team surveyed the scope and sources of education literature and studied the…

Alterations in Functional Connectivity for Language in Prematurely Born Adolescents

ERIC Educational Resources Information Center

Schafer, Robin J.; Lacadie, Cheryl; Vohr, Betty; Kesler, Shelli R.; Katz, Karol H.; Schneider, Karen C.; Pugh, Kenneth R.; Makuch, Robert W.; Reiss, Allan L.; Constable, R. Todd; Ment, Laura R.

2009-01-01

Recent data suggest recovery of language systems but persistent structural abnormalities in the prematurely born. We tested the hypothesis that subjects who were born prematurely develop alternative networks for processing language. Subjects who were born prematurely (n = 22; 600-1250 g birth weight), without neonatal brain injury on neonatal…

Bartlett Experimental Forest

Treesearch

Jane Gamal-Eldin

1998-01-01

The Bartlett Experimental Forest is a field laboratory for research on the ecology and management of northern forest ecosystems. Research on the Bartlett includes: 1) extensive investigations on structure and dynamics of forests at several levels, and developing management alternatives to reflect an array of values and benefits sought by users of forest lands, 2) a...

New Lenses for Viewing Educational Policy: Insights through Imaginative Literature.

ERIC Educational Resources Information Center

Fenwick, Tara J.

This paper calls for an alternative view of educational policy, a departure from the macroperspective currently dominating policy analysis. The latter perspective tends to focus on policy development and implementation issues of politics and control, compliance and measurement, and relationship structures and influences among groups and actors.…

Development of Quantitative Structure-Activity Relationship (QSAR) Models to Predict the Carcinogenic Potency of Chemicals

EPA Science Inventory

Determining the carcinogenicity and carcinogenic potency of new chemicals is both a labor-intensive and time-consuming process. In order to expedite the screening process, there is a need to either: (1) identify alternative toxicity measures (shorter duration) that may be used as...

Understanding Foreign Language Learning Strategies: A Validation Study

ERIC Educational Resources Information Center

Tragant, Elsa; Thompson, Marilyn S.; Victori, Mia

2013-01-01

The present work aims to contribute to our understanding of the underlying dimensions of language learning strategies in foreign language contexts. The study analyzes alternative factor structures underlying a recently developed instrument (Tragant and Victori, 2012) and it includes the age factor in the examination of its construct validity. The…

A Study of Undergraduate Students' Alternative Conceptions of Earth's Interior Using Drawing Tasks

ERIC Educational Resources Information Center

McAllister, Meredith L.

2014-01-01

Learning fundamental geoscience topics such as plate tectonics, earthquakes, and volcanoes requires students to develop a deep understanding of the conceptual models geologists use when describing the structure and dynamics of Earth's interior. Despite the importance of these mental models underlying much of the undergraduate geoscience…

Alternatives for Man and Environment, Revised Curriculum.

ERIC Educational Resources Information Center

Miami-Dade Junior Coll., FL.

A one-year general education course entitled "Man and Environment" has been developed at Miami-Dade Junior College, Florida. Basic framework for the course was built on the premise that an interdisciplinary, module-structured course represents one of the better approaches to planning environmental education curriculum. Material for the…

The Ecology of Learning: A Comparison of Alternative Elementary School Learning Environments.

ERIC Educational Resources Information Center

Hoaglund, Mary; And Others

This paper is the first-year report of a three-year project in Edina, Minnesota, developing a system for measuring differences among classroom environments and organizational patterns. Dimensions measured include teacher preferences for classroom structure, student perceptions of learning environments and classmate behavior, student attitudes,…

Mitigating Settlement of Structures founded on Peat

NASA Astrophysics Data System (ADS)

Wijeyesekera, D. C.; Numbikannu, L.; Ismail, T. N. H. T.; Bakar, I.

2016-07-01

Observations made of two common failures of structures founded on peat/organic soil in Johor, Malaysia is presented. Critical evaluation of current lightweight fill technology to mitigate such settlement is also discussed. Lightweight technology, such as Expanded Polystyrene (EPS), has been used in construction on soft yielding ground for decades. Regrettably, some published information of EPS failures to perform on construction sites are also cited in this paper. This paper outlines some concepts leading to the development of an alternative innovative lightweight fill is that the idealised cellular structure of the GCM permit free flow of water and complemented by the mat structure which evens out any differential settlement A further highlight of this paper is the monitoring of the field performance of this lightweight fill (GCM) as a feasible alternative to fill weight reduction on yielding ground.. Hence, a prime research objective was to compare the fill settlements observed with 1m high fill of surcharge loading on peat ground (comparison of the case of using a partial 0.6m high GCM and that of a total of 1m of conventional sand backfill).

Characterization and optimization of spiral eddy current coils for in-situ crack detection

NASA Astrophysics Data System (ADS)

Mandache, Catalin

2018-03-01

In-situ condition-based maintenance is making strides in the aerospace industry and it is seen as an alternative to scheduled, time-based maintenance. With fatigue cracks originating from fastener holes as the main reason for structural failures, embedded eddy current coils are a viable non-invasive solution for their timely detection. The development and potential broad use of these coils are motivated by a few consistent arguments: (i) inspection of structures of complicated geometries and hard to access areas, that often require disassembly, (ii) alternative to regular inspection actions that could introduce inadvertent damage, (iii) for structures that have short inspection intervals, and (iv) for repaired structures where fastener holes contain bushings and prevent further bolt-hole inspections. Since the spiral coils are aiming at detecting radial cracks emanating from the fastener holes, their design parameters should allow for high inductance, low ohmic losses and power requirements, as well as optimal size and high sensitivity to discontinuities. In this study, flexible, surface conformable, spiral eddy current coils are empirically investigated on mock-up specimens, while numerical analysis is performed for their optimization and design improvement.

Bond Ellipticity Alternation: An Accurate Descriptor of the Nonlinear Optical Properties of π-Conjugated Chromophores.

PubMed

Lopes, Thiago O; Machado, Daniel F Scalabrini; Risko, Chad; Brédas, Jean-Luc; de Oliveira, Heibbe C B

2018-03-15

Well-defined structure-property relationships offer a conceptual basis to afford a priori design principles to develop novel π-conjugated molecular and polymer materials for nonlinear optical (NLO) applications. Here, we introduce the bond ellipticity alternation (BEA) as a robust parameter to assess the NLO characteristics of organic chromophores and illustrate its effectiveness in the case of streptocyanines. BEA is based on the symmetry of the electron density, a physical observable that can be determined from experimental X-ray electron densities or from quantum-chemical calculations. Through comparisons to the well-established bond-length alternation and π-bond order alternation parameters, we demonstrate the generality of BEA to foreshadow NLO characteristics and underline that, in the case of large electric fields, BEA is a more reliable descriptor. Hence, this study introduces BEA as a prominent descriptor of organic chromophores of interest for NLO applications.

Design of a radiator shade for testing in a simulated lunar environment

NASA Technical Reports Server (NTRS)

Huff, Jaimi; Remington, Randy; Tang, Toan

1992-01-01

The National Aeronautics and Space Administration (NASA) and The Universities Space Research Association (USRA) have chosen the parabolic/catenary concept from their sponsored Fall 1991 lunar radiation shade project for further testing and development. NASA asked the design team to build a shading device and support structure for testing in a vacuum chamber. Besides the support structure for the catenary shading device, the design team was asked to develop a system for varying the shade shape so that the device can be tested at different focal lengths. The design team developed concept variants and combined the concept variants to form overall designs. Using a decision matrix, an overall design was selected by the team from several overall design alternatives. Concept variants were developed for three primary functions. The three functions were structural support, shape adjustments, and end shielding. The shade adjustment function was divided into two sub-functions, arc length adjustment, and width adjustment.

Oxygen supply limits the heat tolerance of lizard embryos.

PubMed

Smith, Colton; Telemeco, Rory S; Angilletta, Michael J; VandenBrooks, John M

2015-04-01

The mechanisms that set the thermal limits to life remain uncertain. Classically, researchers thought that heating kills by disrupting the structures of proteins or membranes, but an alternative hypothesis focuses on the demand for oxygen relative to its supply. We evaluated this alternative hypothesis by comparing the lethal temperature for lizard embryos developing at oxygen concentrations of 10-30%. Embryos exposed to normoxia and hyperoxia survived to higher temperatures than those exposed to hypoxia, suggesting that oxygen limitation sets the thermal maximum. As all animals pass through an embryonic stage where respiratory and cardiovascular systems must develop, oxygen limitation may limit the thermal niches of terrestrial animals as well as aquatic ones. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Optimisation of Critical Infrastructure Protection: The SiVe Project on Airport Security

NASA Astrophysics Data System (ADS)

Breiing, Marcus; Cole, Mara; D'Avanzo, John; Geiger, Gebhard; Goldner, Sascha; Kuhlmann, Andreas; Lorenz, Claudia; Papproth, Alf; Petzel, Erhard; Schwetje, Oliver

This paper outlines the scientific goals, ongoing work and first results of the SiVe research project on critical infrastructure security. The methodology is generic while pilot studies are chosen from airport security. The outline proceeds in three major steps, (1) building a threat scenario, (2) development of simulation models as scenario refinements, and (3) assessment of alternatives. Advanced techniques of systems analysis and simulation are employed to model relevant airport structures and processes as well as offences. Computer experiments are carried out to compare and optimise alternative solutions. The optimality analyses draw on approaches to quantitative risk assessment recently developed in the operational sciences. To exploit the advantages of the various techniques, an integrated simulation workbench is build up in the project.

Voices of the poor from the margins of Bengal: structural inequities and health.

PubMed

Dutta, Mohan J; Dutta, Uttaran

2013-01-01

In opposition to the traditional approaches to health communication that treat the subaltern sectors as passive recipients of messages of enlightenment configured in top-down interventions, the culture-centered approach foregrounds the importance of listening to subaltern communities at the margins through dialogue. We build on earlier culture-centered projects in rural communities of West Bengal, India, to develop participatory research strategies for understanding the local processes through which the structural marginalization of the poor plays out in rural Bengal. Study results point toward the marginalization of the poor both communicatively and economically, attending to the ways in which communicative marginalization lies at the heart of economic oppressions. Through locally articulated concepts of "health as shortage" and "communication as shortage," community members put forth alternative rationalities of health that highlight structural resources at the heart of health. These local articulations of shortage offer an alternative rationality for organizing health promotion efforts in the rural margins of Bengal through the foregrounding of discourses of shortage.

Unveiling the molecular mechanism of brassinosteroids: Insights from structure-based molecular modeling studies.

PubMed

Lei, Beilei; Liu, Jiyuan; Yao, Xiaojun

2015-12-01

Brassinosteroid (BR) phytohormones play indispensable roles in plant growth and development. Brassinolide (BL) and 24-epibrassinolide (24-epiBL) are the most active ones among the BRs reported thus far. Unfortunately, the extremely low natural content and intricate synthesis process limit their popularization in agricultural production. Earlier reports to discover alternative compounds have resulted in molecules with nearly same scaffold structure and without diversity in chemical space. In the present study, receptors structure based BRs regulation mechanism was analyzed. First, we examined the detailed binding interactions and their dynamic stability between BL and its receptor BRI1 and co-receptor BAK1. Then, the binding modes and binding free energies for 24-epiBL and a series of representative BRs binding with BRI1 and BRI1-BAK1 were carried out by molecular docking, energy minimization and MM-PBSA free energy calculation. The obtained binding structures and energetic results provided vital insights into the structural factors affecting the activity from both receptors and BRs aspects. Subsequently, the obtained knowledge will serve as valuable guidance to build pharmacophore models for rational screening of new scaffold alternative BRs. Copyright © 2015 Elsevier Inc. All rights reserved.

Secrets of the Chinese magic mirror replica

NASA Astrophysics Data System (ADS)

Mak, Se-yuen; Yip, Din-yan

2001-03-01

We examine the structure of five Chinese magic mirror replicas using a special imaging technique developed by the authors. All mirrors are found to have a two-layered structure. The reflecting surface that gives rise to a projected magic pattern on the screen is hidden under a polished half-reflecting top layer. An alternative method of making the magic mirror using ancient technology has been proposed. Finally, we suggest a simple method of reconstructing a mirror replica in the laboratory.

Service tough composite structures using the Z-direction reinforcement process

NASA Technical Reports Server (NTRS)

Freitas, Glenn; Magee, Constance; Boyce, Joseph; Bott, Richard

1992-01-01

Foster-Miller has developed a new process to provide through thickness reinforcement of composite structures. The process reinforces laminates locally or globally on-tool during standard autoclave processing cycles. Initial test results indicate that the method has the potential to significantly reduce delamination in carbon-epoxy. Laminates reinforced with the z-fiber process have demonstrated significant improvements in mode 1 fracture toughness and compression strength after impact. Unlike alternative methods, in-plane properties are not adversely affected.

Effect of Stitching on Debonding in Composite Structural Elements

NASA Technical Reports Server (NTRS)

Raju, I. S.; Glaessgen, E. H.

2001-01-01

Stitched multiaxial warp knit materials have been suggested as viable alternatives to laminated prepreg materials for large aircraft structures such as wing skins. Analyses have been developed to quantify the effectiveness of stitching for reducing strain energy release rates in skin-stiffener debond, lap joint and sandwich debond configurations. Strain energy release rates were computed using the virtual crack closure technique. In all configurations, the stitches were shown to significantly reduce the strain energy release rate.

Design and analysis of the Collider SPXA/SPRA spool piece vacuum barrier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cruse, G.; Aksel, G.

1993-04-01

A design for the Collider SPXA/SPRA spool piece vacuum barrier was developed to meet a variety of thermal and structural performance requirements. Both composite and stainless steel alternatives were investigated using detailed finite-element analysis before selecting an optimized version of the ASST SPR spool vacuum barrier design. This design meets the structural requirements and will be able to meet the thermal performance requirements by using some newer thermal strapping configurations.

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

PubMed

Childs-Disney, Jessica L; Stepniak-Konieczna, Ewa; Tran, Tuan; Yildirim, Ilyas; Park, HaJeung; Chen, Catherine Z; Hoskins, Jason; Southall, Noel; Marugan, Juan J; Patnaik, Samarjit; Zheng, Wei; Austin, Chris P; Schatz, George C; Sobczak, Krzysztof; Thornton, Charles A; Disney, Matthew D

2013-01-01

The ability to control pre-mRNA splicing with small molecules could facilitate the development of therapeutics or cell-based circuits that control gene function. Myotonic dystrophy type 1 is caused by the dysregulation of alternative pre-mRNA splicing due to sequestration of muscleblind-like 1 protein (MBNL1) by expanded, non-coding r(CUG) repeats (r(CUG)(exp)). Here we report two small molecules that induce or ameliorate alternative splicing dysregulation. A thiophene-containing small molecule (1) inhibits the interaction of MBNL1 with its natural pre-mRNA substrates. Compound (2), a substituted naphthyridine, binds r(CUG)(exp) and displaces MBNL1. Structural models show that 1 binds MBNL1 in the Zn-finger domain and that 2 interacts with UU loops in r(CUG)(exp). This study provides a structural framework for small molecules that target MBNL1 by mimicking r(CUG)(exp) and shows that targeting MBNL1 causes dysregulation of alternative splicing, suggesting that MBNL1 is thus not a suitable therapeutic target for the treatment of myotonic dystrophy type 1.

Induction and Reversal of Myotonic Dystrophy Type 1 Pre-mRNA Splicing Defects by Small Molecules

PubMed Central

Childs-Disney, Jessica L.; Stepniak-Konieczna, Ewa; Tran, Tuan; Yildirim, Ilyas; Park, HaJeung; Chen, Catherine Z.; Hoskins, Jason; Southall, Noel; Marugan, Juan J.; Patnaik, Samarjit; Zheng, Wei; Austin, Chris P.; Schatz, George C.; Sobczak, Krzysztof; Thornton, Charles A.; Disney, Matthew D.

2013-01-01

The ability to control pre-mRNA splicing with small molecules could facilitate the development of therapeutics or cell-based circuits that control gene function. Myotonic dystrophy type 1 (DM1) is caused by the dysregulation of alternative pre-mRNA splicing due to sequestration of muscleblind-like 1 protein (MBNL1) by expanded, non-coding r(CUG) repeats (r(CUG)exp). Here we report two small molecules that induce or ameliorate alternative splicing dysregulation. The thiophene-containing small molecule (1) inhibits the interaction of MBNL1 with its natural pre-mRNA substrates. Compound (2), a substituted naphthyridine, binds r(CUG)exp and displaces MBNL1. Structural models show that 1 binds MBNL1 in the Zn-finger domain and that 2 interacts with UU loops in r(CUG)exp. This study provides a structural framework for small molecules that target MBNL1 by mimicking r(CUG)exp and shows that targeting MBNL1 causes dysregulation of alternative splicing, suggesting that MBNL1 is thus not a suitable therapeutic target for the treatment of DM1. PMID:23806903

Mobility-Resolved Ion Selection in Uniform Drift Field Ion Mobility Spectrometry/Mass Spectrometry: Dynamic Switching in Structures for Lossless Ion Manipulations

DOE PAGES

Webb, Ian K.; Garimella, Sandilya V. B.; Tolmachev, Aleksey V.; ...

2014-09-15

A Structures for Lossless Ion Manipulations (SLIM) module that allows ion mobility separations and the switching of ions between alternative drift paths is described. The SLIM switch component has a “Tee” configuration and allows switching of ions between a linear path and a 90-degree bend. By controlling switching times, ions can be deflected to an alternative channel as a function of their mobilities. In the initial evaluation the switch is used in a static mode and shown compatible with high performance ion mobility separations at 4 torr. In the “dynamic mode” we show that mobility-selected ions can be switched intomore » the alternative channel, and that various ion species can be independently selected based on their mobilities for time-of-flight mass spectrometer (TOF MS) IMS detection and mass analysis. Ultimately, this development also provides the basis for e.g. the selection of specific mobilities for storage and accumulation, and key modules for the assembly of SLIM devices enabling much more complex sequences of ion manipulations.« less

Genome structure drives patterns of gene family evolution in ciliates, a case study using Chilodonella uncinata (Protista, Ciliophora, Phyllopharyngea).

PubMed

Gao, Feng; Song, Weibo; Katz, Laura A

2014-08-01

In most lineages, diversity among gene family members results from gene duplication followed by sequence divergence. Because of the genome rearrangements during the development of somatic nuclei, gene family evolution in ciliates involves more complex processes. Previous work on the ciliate Chilodonella uncinata revealed that macronuclear β-tubulin gene family members are generated by alternative processing, in which germline regions are alternatively used in multiple macronuclear chromosomes. To further study genome evolution in this ciliate, we analyzed its transcriptome and found that (1) alternative processing is extensive among gene families; and (2) such gene families are likely to be C. uncinata specific. We characterized additional macronuclear and micronuclear copies of one candidate alternatively processed gene family-a protein kinase domain containing protein (PKc)-from two C. uncinata strains. Analysis of the PKc sequences reveals that (1) multiple PKc gene family members in the macronucleus share some identical regions flanked by divergent regions; and (2) the shared identical regions are processed from a single micronuclear chromosome. We discuss analogous processes in lineages across the eukaryotic tree of life to provide further insights on the impact of genome structure on gene family evolution in eukaryotes. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

Structural design of liquid oxygen/liquid methane robotic lander JANUS

NASA Astrophysics Data System (ADS)

Chaidez, Mariana

As the attempt to send humans to Mars has gained momentum in the last decade, the need to find alternative propellants that are safer, less toxic, and yields a better performance has become apparent [1]. Liquid methane and oxygen have emerged as a suitable alternative. In addition, the incorporation of liquid methane/liquid oxygen into the propulsion system has demonstrated an increase in engine performance, as well as a reduction in the volume, size and complexity of the propulsion system. In an attempt to further understand the technologies that are possible to develop using liquid oxygen (LO 2) and liquid methane (LCH4), a preliminary design of a robotic lander JANUS is being completed by the Center for Space Exploration and Technology Research (cSTER). The structural design of the vehicle is important because it acts as the skeleton of the vehicle and dictates the maneuverability of the robotic lander. To develop the structure of the robotic lander, six different design vehicle concepts with varying tank configurations were considered. Finite Element Analysis (FEA) was completed on each model to optimize each vehicle. Trade studies were completed to choose the best design for JANUS. Upon completion of the trade studies the design for the first prototype of JANUS was initiated in which the tank and thrust modules were designed. This thesis will describe the design process for the structural design of the JANUS.

46 CFR 177.340 - Alternate design considerations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Alternate design considerations. 177.340 Section 177.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design,...

46 CFR 177.340 - Alternate design considerations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Alternate design considerations. 177.340 Section 177.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design,...

46 CFR 177.340 - Alternate design considerations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Alternate design considerations. 177.340 Section 177.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design,...

Economic Evaluation of Computerized Structural Analysis

NASA Technical Reports Server (NTRS)

Fortin, P. E.

1985-01-01

This completed effort involved a technical and economic study of the capabilities of computer programs in the area of structural analysis. The applicability of the programs to NASA projects and to other users was studied. The applications in other industries was explored including both research and development and applied areas. The costs of several alternative analysis programs were compared. A literature search covered applicable technical literature including journals, trade publications and books. In addition to the literature search, several commercial companies that have developed computerized structural analysis programs were contacted and their technical brochures reviewed. These programs include SDRC I-DEAS, MSC/NASTRAN, SCADA, SUPERSAP, NISA/DISPLAY, STAAD-III, MICAS, GTSTRUDL, and STARS. These programs were briefly reviewed as applicable to NASA projects.

Street as Sustainable City Structural Element

NASA Astrophysics Data System (ADS)

Leyzerova, A. V.; Bagina, E. J.

2017-11-01

Sustainability in architecture is nowadays of particular significance in the course of globalization and information density. The technospehere spontaneous development poses a threat to the sustainability of traditional urban forms where a street is one of the essential forming elements in the urban structure. The article proposes to consider formally compositional street features in relation to one of the traditional streets in the historic center of Ekaterinburg. The study examines the street-planning structure, the development of its skeleton elements, silhouette and fabric elevation characteristics as well as the scale characteristics and visual complexity of objects. The study provided architectural and artistic aspects of street sustainability, and limits of the appropriate scale and composition consistency under which the compatibility of alternative compositional forms existing at different times is possible.

Structure Design Approach and Technology Selection for Next Generation European Launchers

NASA Astrophysics Data System (ADS)

Baiocco, P.; Ramusat, G.; Kauffmann, J.; Jaredson, D.; Bouilly, Th.; Lavelle, F.; Louaas, E.

2012-07-01

In the framework of the next generation launchers activity at ESA, a top-down and a bottom-up approach has been performed for the alternative conception and promising technologies of NGL sub-assemblies and sub-systems. The top-down approach consisted in looking for system-driven design solutions and the bottom-up in the proposal of design solutions taking to substantial advantages for the system. The main investigations have been focused on structures and technologies tight to structures and interfaces. Specifications coming from a preliminary system design have been used in order to permit sub-system design with the goal to find the major advantage for the overall launch system. In this respect selection criteria have been identified and among these a specific evaluation of the payload mass over recurring cost advantage has been evaluated. The development cost, recurring cost and operational aspects have been considered as competitiveness factors for the identification of the most interesting solutions. The TRL/IRL has been assessed and a preliminary development plan has been identified. This approach is dedicated to reference NGL architectures, but alternative architectures have been investigated in order to assess their interest in terms of competitiveness factors and study of other technologies. This paper deals mainly with metallic and composite structures owing to sub-systems or sub-assemblies proposed for the NGL. The major sub-systems and structures analysed are the engine thrust frame (ETF), inter stage structures (ISS), cryogenic propellant tanks, feeding lines and attachments, pressurisation systems and fairing. The paper provides an overview of the main results of this investigation and the potential benefit it can provide.

Quantitative structure-activation barrier relationship modeling for Diels-Alder ligations utilizing quantum chemical structural descriptors.

PubMed

Nandi, Sisir; Monesi, Alessandro; Drgan, Viktor; Merzel, Franci; Novič, Marjana

2013-10-30

In the present study, we show the correlation of quantum chemical structural descriptors with the activation barriers of the Diels-Alder ligations. A set of 72 non-catalysed Diels-Alder reactions were subjected to quantitative structure-activation barrier relationship (QSABR) under the framework of theoretical quantum chemical descriptors calculated solely from the structures of diene and dienophile reactants. Experimental activation barrier data were obtained from literature. Descriptors were computed using Hartree-Fock theory using 6-31G(d) basis set as implemented in Gaussian 09 software. Variable selection and model development were carried out by stepwise multiple linear regression methodology. Predictive performance of the quantitative structure-activation barrier relationship (QSABR) model was assessed by training and test set concept and by calculating leave-one-out cross-validated Q2 and predictive R2 values. The QSABR model can explain and predict 86.5% and 80% of the variances, respectively, in the activation energy barrier training data. Alternatively, a neural network model based on back propagation of errors was developed to assess the nonlinearity of the sought correlations between theoretical descriptors and experimental reaction barriers. A reasonable predictability for the activation barrier of the test set reactions was obtained, which enabled an exploration and interpretation of the significant variables responsible for Diels-Alder interaction between dienes and dienophiles. Thus, studies in the direction of QSABR modelling that provide efficient and fast prediction of activation barriers of the Diels-Alder reactions turn out to be a meaningful alternative to transition state theory based computation.

Lithographically-generated 3D lamella layers and their structural color

NASA Astrophysics Data System (ADS)

Zhang, Sichao; Chen, Yifang; Lu, Bingrui; Liu, Jianpeng; Shao, Jinhai; Xu, Chen

2016-04-01

Inspired by the structural color from the multilayer nanophotonic structures in Morpho butterfly wing scales, 3D lamellae layers in dielectric polymers (polymethyl methacrylate, PMMA) with n ~ 1.5 were designed and fabricated by standard top-down electron beam lithography with one-step exposure followed by an alternating development/dissolution process of PMMA/LOR (lift-off resist) multilayers. This work offers direct proof of the structural blue/green color via lithographically-replicated PMMA/air multilayers, analogous to those in real Morpho butterfly wings. The success of nanolithography in this work for the 3D lamellae structures in dielectric polymers not only enables us to gain deeper insight into the mysterious blue color of the Morpho butterfly wings, but also breaks through the bottleneck in technical development toward broad applications in gas/liquid sensors, 3D meta-materials, coloring media, and infrared imaging devices, etc.

Alternative technological development for RF hybridization

NASA Astrophysics Data System (ADS)

Antônio Finardi, Célio; da Fontoura Ponchet, André; Battesini Adamo, Cristina; Flacker, Alexander; Cotrin Teixeira, Ricardo; Panepucci, Roberto Ricardo

2017-03-01

The paper presents a technological solution for high frequency packaging platform evaluated up to 40 GHz. The main purpose of this development was to define an alternative hybrid technology that is more flexible and faster to prototype compared with thin film or multi chip module (MCM-D). The alternative technology also shows adequate performance for high bit rate solutions integrating optical and electronics blocks. This approach consists of a soft substrate (laminate material), plating processes (electroless Ni-P/Au, electrolytic Au) and lithography patterning. Ground coplanar waveguide was used for microwave structures with excellent ground planes connections due to easy via holes implementation. We present results of high frequency packaging of important RF blocks, such as integrated broadband bias-T, transimpedance amplifier ICs and silicon photonics optical modulators. The paper demonstrates a solution for high frequency hybridization that can be implemented with standard substrates, designed with any shape and with large numbers of metalized via holes and compatible with usual assembling techniques.

Nanocarpets for Trapping Microscopic Particles

NASA Technical Reports Server (NTRS)

Noca, Flavio; Chen, Fei; Hunt, Brian; Bronikowski, Michael; Hoenk, Michael; Kowalczyk, Robert; Choi, Daniel

2004-01-01

Nanocarpets that is, carpets of carbon nanotubes are undergoing development as means of trapping microscopic particles for scientific analysis. Examples of such particles include inorganic particles, pollen, bacteria, and spores. Nanocarpets can be characterized as scaled-down versions of ordinary macroscopic floor carpets, which trap dust and other particulate matter, albeit not purposefully. Nanocarpets can also be characterized as mimicking both the structure and the particle-trapping behavior of ciliated lung epithelia, the carbon nanotubes being analogous to cilia. Carbon nanotubes can easily be chemically functionalized for selective trapping of specific particles of interest. One could, alternatively, use such other three-dimensionally-structured materials as aerogels and activated carbon for the purposeful trapping of microscopic particles. However, nanocarpets offer important advantages over these alternative materials: (1) Nanocarpets are amenable to nonintrusive probing by optical means; and (2) Nanocarpets offer greater surface-to-volume ratios.

Eco-organic tourism as an element of the sustainable development of territories

NASA Astrophysics Data System (ADS)

Ivanov, D. V.; Ziganshin, I. I.

2018-01-01

Organic agricultural production is an ecologically oriented alternative to traditional agriculture and is aimed at ensuring food and environmental safety of the population and territories. The development of ecological tourism on the basis of organic production farms is considered as a promising direction in the development of regional programs for the sustainable development of territories. Studies have shown that, farms engaged in the production of organic products in the Republic of Tatarstan have a significant potential for the development of eco-organic tourism using elements of the nature protection structure.

Architecture and data processing alternatives for the TSE computer. Volume 3: Execution of a parallel counting algorithm using array logic (Tse) devices

NASA Technical Reports Server (NTRS)

Metcalfe, A. G.; Bodenheimer, R. E.

1976-01-01

A parallel algorithm for counting the number of logic-l elements in a binary array or image developed during preliminary investigation of the Tse concept is described. The counting algorithm is implemented using a basic combinational structure. Modifications which improve the efficiency of the basic structure are also presented. A programmable Tse computer structure is proposed, along with a hardware control unit, Tse instruction set, and software program for execution of the counting algorithm. Finally, a comparison is made between the different structures in terms of their more important characteristics.

Probabilistic Structural Analysis Methods (PSAM) for select space propulsion system components

NASA Technical Reports Server (NTRS)

1991-01-01

The fourth year of technical developments on the Numerical Evaluation of Stochastic Structures Under Stress (NESSUS) system for Probabilistic Structural Analysis Methods is summarized. The effort focused on the continued expansion of the Probabilistic Finite Element Method (PFEM) code, the implementation of the Probabilistic Boundary Element Method (PBEM), and the implementation of the Probabilistic Approximate Methods (PAppM) code. The principal focus for the PFEM code is the addition of a multilevel structural dynamics capability. The strategy includes probabilistic loads, treatment of material, geometry uncertainty, and full probabilistic variables. Enhancements are included for the Fast Probability Integration (FPI) algorithms and the addition of Monte Carlo simulation as an alternate. Work on the expert system and boundary element developments continues. The enhanced capability in the computer codes is validated by applications to a turbine blade and to an oxidizer duct.

A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation.

PubMed

Daneshian, Mardas; Akbarsha, Mohammad A; Blaauboer, Bas; Caloni, Francesca; Cosson, Pierre; Curren, Rodger; Goldberg, Alan; Gruber, Franz; Ohl, Frauke; Pfaller, Walter; van der Valk, Jan; Vinardell, Pilar; Zurlo, Joanne; Hartung, Thomas; Leist, Marcel

2011-01-01

Development of improved communication and education strategies is important to make alternatives to the use of animals, and the broad range of applications of the 3Rs concept better known and understood by different audiences. For this purpose, the Center for Alternatives to Animal Testing in Europe (CAAT-Europe) together with the Transatlantic Think Tank for Toxicology (t(4)) hosted a three-day workshop on "Teaching Alternative Methods to Animal Experimentation". A compilation of the recommendations by a group of international specialists in the field is summarized in this report. Initially, the workshop participants identified the different audience groups to be addressed and also the communication media that may be used. The main outcome of the workshop was a framework for a comprehensive educational program. The modular structure of the teaching program presented here allows adaptation to different audiences with their specific needs; different time schedules can be easily accommodated on this basis. The topics cover the 3Rs principle, basic research, toxicological applications, method development and validation, regulatory aspects, case studies and ethical aspects of 3Rs approaches. This expert consortium agreed to generating teaching materials covering all modules and providing them in an open access online repository.

Contributions of dorsal striatal subregions to spatial alternation behavior.

PubMed

Moussa, Roula; Poucet, Bruno; Amalric, Marianne; Sargolini, Francesca

2011-07-01

Considerable evidence has shown a clear dissociation between the dorsomedial (DMS) and the dorsolateral (DLS) striatum in instrumental conditioning. In particular, DMS activity is necessary to form action-outcome associations, whereas the DLS is required for developing habitual behavior. However, few studies have investigated whether a similar dissociation exists in more complex goal-directed learning processes. The present study examined the role of the two structures in such complex learning by analyzing the effects of excitotoxic DMS and DLS lesions during the acquisition and extinction of spatial alternation behavior, in a continuous alternation T-maze task. We demonstrate that DMS and DLS lesions have opposite effects, the former impairing and the latter improving animal performance during learning and extinction. DMS lesions may impair the acquisition of spatial alternation behavior by disrupting the signal necessary to link a goal with a specific spatial sequence. In contrast, DLS lesions may accelerate goal-driven strategies by minimizing the influence of external stimuli on the response, thus increasing the impact of action-reward contingencies. Taken together, these results suggest that DMS- and DLS-mediated learning strategies develop in parallel and compete for the control of the behavioral response early in learning.

Design of controlled elastic and inelastic structures

NASA Astrophysics Data System (ADS)

Reinhorn, A. M.; Lavan, O.; Cimellaro, G. P.

2009-12-01

One of the founders of structural control theory and its application in civil engineering, Professor Emeritus Tsu T. Soong, envisioned the development of the integral design of structures protected by active control devices. Most of his disciples and colleagues continuously attempted to develop procedures to achieve such integral control. In his recent papers published jointly with some of the authors of this paper, Professor Soong developed design procedures for the entire structure using a design — redesign procedure applied to elastic systems. Such a procedure was developed as an extension of other work by his disciples. This paper summarizes some recent techniques that use traditional active control algorithms to derive the most suitable (optimal, stable) control force, which could then be implemented with a combination of active, passive and semi-active devices through a simple match or more sophisticated optimal procedures. Alternative design can address the behavior of structures using Liapunov stability criteria. This paper shows a unified procedure which can be applied to both elastic and inelastic structures. Although the implementation does not always preserve the optimal criteria, it is shown that the solutions are effective and practical for design of supplemental damping, stiffness enhancement or softening, and strengthening or weakening.

Use of structured decision making to identify monitoring variables and management priorities for salt marsh ecosystems

USGS Publications Warehouse

Neckles, Hilary A.; Lyons, James E.; Guntenspergen, Glenn R.; Shriver, W. Gregory; Adamowicz, Susan C.

2015-01-01

Most salt marshes in the USA have been degraded by human activities, and coastal managers are faced with complex choices among possible actions to restore or enhance ecosystem integrity. We applied structured decision making (SDM) to guide selection of monitoring variables and management priorities for salt marshes within the National Wildlife Refuge System in the northeastern USA. In general, SDM is a systematic process for decomposing a decision into its essential elements. We first engaged stakeholders in clarifying regional salt marsh decision problems, defining objectives and attributes to evaluate whether objectives are achieved, and developing a pool of alternative management actions for achieving objectives. Through this process, we identified salt marsh attributes that were applicable to monitoring National Wildlife Refuges on a regional scale and that targeted management needs. We then analyzed management decisions within three salt marsh units at Prime Hook National Wildlife Refuge, coastal Delaware, as a case example of prioritizing management alternatives. Values for salt marsh attributes were estimated from 2 years of baseline monitoring data and expert opinion. We used linear value modeling to aggregate multiple attributes into a single performance score for each alternative, constrained optimization to identify alternatives that maximized total management benefits subject to refuge-wide cost constraints, and used graphical analysis to identify the optimal set of alternatives for the refuge. SDM offers an efficient, transparent approach for integrating monitoring into management practice and improving the quality of management decisions.

A Multifunctional Hot Structure Heatshield Concept for Planetary Entry

NASA Technical Reports Server (NTRS)

Walker, Sandra P.; Daryabeigi, Kamran; Samareh, Jamshid A.; Wagner, Robert; Waters, Allen

2015-01-01

A multifunctional hot structure heatshield concept is being developed to provide technology enhancements with significant benefits compared to the current state-of-the-art heatshield technology. These benefits can potentially enable future planetary missions. The concept is unique in integrating the function of the thermal protection system with the primary load carrying structural component. An advanced carbon-carbon material system has been evaluated for the load carrying structure, which will be utilized on the outer surface of the heatshield, and thus will operate as a hot structure exposed to the severe aerodynamic heating associated with planetary entry. Flexible, highly efficient blanket insulation is sized for use underneath the hot structure to maintain required operational internal temperatures. The approach followed includes developing preliminary designs to demonstrate feasibility of the concept and benefits over a traditional, baseline design. Where prior work focused on a concept for an Earth entry vehicle, the current efforts presented here are focused on developing a generic heatshield model and performing a trade study for a Mars entry application. This trade study includes both structural and thermal evaluation. The results indicate that a hot structure concept is a feasible alternative to traditional heatshields and may offer advantages that can enable future entry missions.

Development and classification of an operational definition of complementary and alternative medicine for the Cochrane Collaboration

PubMed Central

Wieland, L. Susan; Manheimer, Eric; Berman, Brian M.

2011-01-01

Over the past decade the Cochrane Collaboration has been an increasingly important source of information on complementary and alternative medicine (CAM) therapies. From 2007 to 2008 the Cochrane CAM Field developed a topics list that allowed us to categorize all 396 Cochrane reviews related to CAM (as of The Cochrane Library, Issue 4, 2009). This topics list is an advance in making Cochrane reviews on CAM topics accessible to the public. In this paper, we discuss challenges in developing the topics list, including developing an operational definition of CAM, deciding which reviews should be included within the CAM Field’s scope, developing the structured list of CAM Field-specific topics, and determining where in the topics list the reviews should be placed. Although aspects of our operational definition of CAM are open to revision, a standardized definition provides us with an objective, reproducible and systematic method for defining and classifying CAM therapies. PMID:21717826

A practical alternative to single tree selection?

Treesearch

Gary W. Miller; H. Clay Smith

1993-01-01

When landowners want to develop and maintain an uneven-aged tree structure in eastern hardwood stands, single-tree selection often is suggested as the only advisable, long-term partial regeneration harvest method. Single-tree selection is preferred because it provides a means for improving quality and controlling stocking of the residual stand necessary for sustained...

Efficient concepts for large erectable space structures

NASA Technical Reports Server (NTRS)

Card, M. F.; Bush, H. G.; Heard, W. L., Jr.; Mikulas, M. M., Jr.

1978-01-01

The status of Langley Research Center development of the nestable column concept is reviewed including results of member and truss component tests, and planned assembly studies. In addition, more recent studies of alternative member concepts are presented. Preliminary results on relative efficiency of several types of truss-type columns are compared and future test plans discussed.

Redox Abnormalities as a Vulnerability Phenotype for Autism and Related Alternations in CNS Development

DTIC Science & Technology

2009-10-01

2004. MECP2 structural and 3’-UTR variants in schizophrenia , autism and other psychiatric diseases: a possible association with autism. Am J Med...inhibition, thus potentially enabling enhancement of remyelination. Role: PI Award letter dated 12/11/06 Noble (PI) Cure Autism Now Foundation 02/05

Monkey Lipsmacking Develops Like the Human Speech Rhythm

ERIC Educational Resources Information Center

Morrill, Ryan J.; Paukner, Annika; Ferrari, Pier F.; Ghazanfar, Asif A.

2012-01-01

Across all languages studied to date, audiovisual speech exhibits a consistent rhythmic structure. This rhythm is critical to speech perception. Some have suggested that the speech rhythm evolved "de novo" in humans. An alternative account--the one we explored here--is that the rhythm of speech evolved through the modification of rhythmic facial…

A Critical Exploration of Collaborative and Distributed Leadership in Higher Education: Developing an Alternative Ontology through Leadership-as-Practice

ERIC Educational Resources Information Center

Youngs, Howard

2017-01-01

Since the turn of the millennium, interest in collaborative and distributed conceptualisations of leadership has gathered momentum, particularly in education. During the same period, higher education institutions have been embedded in practices shaped by New Public Management. The resultant reconfiguration of structural arrangements within…

User Acceptance of a Haptic Interface for Learning Anatomy

ERIC Educational Resources Information Center

Yeom, Soonja; Choi-Lundberg, Derek; Fluck, Andrew; Sale, Arthur

2013-01-01

Visualizing the structure and relationships in three dimensions (3D) of organs is a challenge for students of anatomy. To provide an alternative way of learning anatomy engaging multiple senses, we are developing a force-feedback (haptic) interface for manipulation of 3D virtual organs, using design research methodology, with iterations of system…

New Structures and Approaches for Teacher Preparation: Do They Make a Difference in Teacher Retention?

ERIC Educational Resources Information Center

Harris, Steven A.; Camp, William E.; Adkison, Judith

Low initial employment rates and high attrition among teachers are factors recognized as major contributors to the national teacher shortage. This research compared the effectiveness of three teacher preparation methods used in Texas: alternative certification programs (ACPs), Centers for Professional Development and Technology (CPDTs), and…

Mind Map Marketing: A Creative Approach in Developing Marketing Skills

ERIC Educational Resources Information Center

Eriksson, Lars Torsten; Hauer, Amie M.

2004-01-01

In this conceptual article, the authors describe an alternative course structure that joins learning key marketing concepts to creative problem solving. The authors describe an approach using a convergent-divergent-convergent (CDC) process: key concepts are first derived from case material to be organized in a marketing matrix, which is then used…

Potsdam College Advocate Program: An Alternative to Speech Regulations.

ERIC Educational Resources Information Center

Gordon, Anna

The Potsdam Advocate program is a program designed to aid students who feel they are victims of discrimination or sexual offenses. An analysis of this program and its literature is instructive to students and scholars in the field of organizational communication. Developed in 1991, this program provides a structure and options that students may…

Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases.

PubMed

Ortigão-Farias, João Ramalho; Di-Blasi, Tatiana; Telleria, Erich Loza; Andorinho, Ana Carolina; Lemos-Silva, Thais; Ramalho-Ortigão, Marcelo; Tempone, Antônio Jorge; Traub-Csekö, Yara Maria

2018-02-01

BACKGROUND The insect chitinase gene family is composed by more than 10 paralogs, which can codify proteins with different domain structures. In Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil, a chitinase cDNA from adult female insects was previously characterized. The predicted protein contains one catalytic domain and one chitin-binding domain (CBD). The expression of this gene coincided with the end of blood digestion indicating a putative role in peritrophic matrix degradation. OBJECTIVES To determine the occurrence of alternative splicing in chitinases of L. longipalpis. METHODS We sequenced the LlChit1 gene from a genomic clone and the three spliced forms obtained by reverse transcription polymerase chain reaction (RT-PCR) using larvae cDNA. FINDINGS We showed that LlChit1 from L. longipalpis immature forms undergoes alternative splicing. The spliced form corresponding to the adult cDNA was named LlChit1A and the two larvae specific transcripts were named LlChit1B and LlChit1C. The B and C forms possess stop codons interrupting the translation of the CBD. The A form is present in adult females post blood meal, L4 larvae and pre-pupae, while the other two forms are present only in L4 larvae and disappear just before pupation. Two bands of the expected size were identified by Western blot only in L4 larvae. MAIN CONCLUSIONS We show for the first time alternative splicing generating chitinases with different domain structures increasing our understanding on the finely regulated digestion physiology and shedding light on a potential target for controlling L. longipalpis larval development.

How honest are the signals? A protocol for validating wearable sensors.

PubMed

Kayhan, Varol Onur; Chen, Zheng Chris; French, Kimberly A; Allen, Tammy D; Salomon, Kristen; Watkins, Alison

2018-02-01

There is growing interest among organizational researchers in tapping into alternative sources of data beyond self-reports to provide a new avenue for measuring behavioral constructs. Use of alternative data sources such as wearable sensors is necessary for developing theory and enhancing organizational practice. Although wearable sensors are now commercially available, the veracity of the data they capture is largely unknown and mostly based on manufacturers' claims. The goal of this research is to test the validity and reliability of data captured by one such wearable badge (by Humanyze) in the context of structured meetings where all individuals wear a badge for the duration of the encounter. We developed a series of studies, each targeting a specific sensor of this badge that is relevant for structured meetings, and we make specific recommendations for badge data usage based on our validation results. We have incorporated the insights from our studies on a website that researchers can use to conduct validation tests for their badges, upload their data, and assess the validity of the data. We discuss this website in the corresponding studies.

A morphospace for synthetic organs and organoids: the possible and the actual.

PubMed

Ollé-Vila, Aina; Duran-Nebreda, Salva; Conde-Pueyo, Núria; Montañez, Raúl; Solé, Ricard

2016-04-18

Efforts in evolutionary developmental biology have shed light on how organs are developed and why evolution has selected some structures instead of others. These advances in the understanding of organogenesis along with the most recent techniques of organotypic cultures, tissue bioprinting and synthetic biology provide the tools to hack the physical and genetic constraints in organ development, thus opening new avenues for research in the form of completely designed or merely altered settings. Here we propose a unifying framework that connects the concept of morphospace (i.e. the space of possible structures) with synthetic biology and tissue engineering. We aim for a synthesis that incorporates our understanding of both evolutionary and architectural constraints and can be used as a guide for exploring alternative design principles to build artificial organs and organoids. We present a three-dimensional morphospace incorporating three key features associated to organ and organoid complexity. The axes of this space include the degree of complexity introduced by developmental mechanisms required to build the structure, its potential to store and react to information and the underlying physical state. We suggest that a large fraction of this space is empty, and that the void might offer clues for alternative ways of designing and even inventing new organs.

Tectonic wedging in the forearc basin - Accretionary prism transition, Lesser Antilles forearc

NASA Technical Reports Server (NTRS)

Torrini, Rudolph, Jr.; Speed, Robert C.

1989-01-01

This paper describes regional structure of the inner forearc of the southern Lesser Antilles, which contains an extensive 50-70 km wide inner forearc deformation belt (IFDB) developed above crystalline basement of the undeformed forearc basin (FAB), close to and perhaps above its probable subduction trace with Atlantic lithosphere. The IFDB is analyzed, with emphasis placed on five transects across the belt, using mainly migrated seismic sections and balanced model cross sections. The IFDB features and its evolution are discussed, with special attention given to the major structures divided by early and late stages of development, paleobathymetric history, event timing, displacement and strain, and alternative tectonic explanations.

Geometrically nonlinear analysis of laminated elastic structures

NASA Technical Reports Server (NTRS)

Reddy, J. N.

1984-01-01

Laminated composite plates and shells that can be used to model automobile bodies, aircraft wings and fuselages, and pressure vessels among many other were analyzed. The finite element method, a numerical technique for engineering analysis of structures, is used to model the geometry and approximate the solution. Various alternative formulations for analyzing laminated plates and shells are developed and their finite element models are tested for accuracy and economy in computation. These include the shear deformation laminate theory and degenerated 3-D elasticity theory for laminates.

Method of examining microcircuit patterns

NASA Technical Reports Server (NTRS)

Suszko, S. F. (Inventor)

1986-01-01

Examination of microstructures of LSI and VLSI devices is facilitated by employing a method in which the device is photographed through a darkfield illumination optical microscope and the resulting negative subjected to inverse processing to form a positive on a photographic film. The film is then developed to form photographic prints or transparencies which clearly illustrate the structure of the device. The entire structure of a device may be examined by alternately photographing the device and selectively etching layers of the device in order to expose underlying layers.

Technically Speaking: On the Structure and Experience of Interaction Involving Augmentative Alternative Communications

ERIC Educational Resources Information Center

Engelke, Christopher Robert

2013-01-01

Technically Speaking: On the Structure and Experience of Interaction Involving Augmentative Alternative Communications examines the ways that communication is structured and experienced by looking at interactions involving augmented communicators--people with severe speech disabilities who use forms of assistive technology in order to communicate…

Apparatus for efficient sidewall containment of molten metal with horizontal alternating magnetic fields utilizing low reluctance rims

DOEpatents

Praeg, Walter F.

1999-01-01

A method and apparatus for casting sheets of metal from molten metal. The apparatus includes a containment structure having an open side, a horizontal alternating magnetic field generating structure and rollers including low reluctance rim structures. The magnetic field and the rollers help contain the molten metal from leaking out of the containment structure.

Structured decision making for managing pneumonia epizootics in bighorn sheep

USGS Publications Warehouse

Sells, Sarah N.; Mitchell, Michael S.; Edwards, Victoria L.; Gude, Justin A.; Anderson, Neil J.

2016-01-01

Good decision-making is essential to conserving wildlife populations. Although there may be multiple ways to address a problem, perfect solutions rarely exist. Managers are therefore tasked with identifying decisions that will best achieve desired outcomes. Structured decision making (SDM) is a method of decision analysis used to identify the most effective, efficient, and realistic decisions while accounting for values and priorities of the decision maker. The stepwise process includes identifying the management problem, defining objectives for solving the problem, developing alternative approaches to achieve the objectives, and formally evaluating which alternative is most likely to accomplish the objectives. The SDM process can be more effective than informal decision-making because it provides a transparent way to quantitatively evaluate decisions for addressing multiple management objectives while incorporating science, uncertainty, and risk tolerance. To illustrate the application of this process to a management need, we present an SDM-based decision tool developed to identify optimal decisions for proactively managing risk of pneumonia epizootics in bighorn sheep (Ovis canadensis) in Montana. Pneumonia epizootics are a major challenge for managers due to long-term impacts to herds, epistemic uncertainty in timing and location of future epizootics, and consequent difficulty knowing how or when to manage risk. The decision tool facilitates analysis of alternative decisions for how to manage herds based on predictions from a risk model, herd-specific objectives, and predicted costs and benefits of each alternative. Decision analyses for 2 example herds revealed that meeting management objectives necessitates specific approaches unique to each herd. The analyses showed how and under what circumstances the alternatives are optimal compared to other approaches and current management. Managers can be confident that these decisions are effective, efficient, and realistic because they explicitly account for important considerations managers implicitly weigh when making decisions, including competing management objectives, uncertainty in potential outcomes, and risk tolerance.

Developing a taxonomy for mission architecture definition

NASA Technical Reports Server (NTRS)

Neubek, Deborah J.

1990-01-01

The Lunar and Mars Exploration Program Office (LMEPO) was tasked to define candidate architectures for the Space Exploration Initiative to submit to NASA senior management and an externally constituted Outreach Synthesis Group. A systematic, structured process for developing, characterizing, and describing the alternate mission architectures, and applying this process to future studies was developed. The work was done in two phases: (1) national needs were identified and categorized into objectives achievable by the Space Exploration Initiative; and (2) a program development process was created which both hierarchically and iteratively describes the program planning process.

ISAAC - A Testbed for Advanced Composites Research

NASA Technical Reports Server (NTRS)

Wu, K. Chauncey; Stewart, Brian K.; Martin, Robert A.

2014-01-01

The NASA Langley Research Center is acquiring a state-of-art composites fabrication environment to support the Center's research and technology development mission. This overall system described in this paper is named ISAAC, or Integrated Structural Assembly of Advanced Composites. ISAAC's initial operational capability is a commercial robotic automated fiber placement system from Electroimpact, Inc. that consists of a multi-degree of freedom commercial robot platform, a tool changer mechanism, and a specialized automated fiber placement end effector. Examples are presented of how development of advanced composite materials, structures, fabrication processes and technology are enabled by utilizing the fiber placement end effector directly or with appropriate modifications. Alternatively, end effectors with different capabilities may either be bought or developed with NASA's partners in industry and academia.

Structural Basis by Which Alternative Splicing Modulates the Organizer Activity of FGF8 in the Brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olsen,S.; Li, J.; Eliseenkova, A.

2006-01-01

Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-hindbrain region during development. Although the only difference between these isoforms is the presence of an additional 11 amino acids at the N terminus of FGF8b, these isoforms possess remarkably different abilities to pattern the midbrain and anterior hindbrain. To reveal the structural basis by which alternative splicing modulates the organizing activity of FGF8, we solved the crystal structure of FGF8b in complex with the 'c' splice isoform of FGF receptor 2 (FGFR2c). Using surface plasmon resonance (SPR), we also characterized the receptor-binding specificity ofmore » FGF8a and FGF8b, the 'b' isoform of FGF17 (FGF17b), and FGF18. The FGF8b-FGFR2c structure shows that alternative splicing permits a single additional contact between phenylalanine 32 (F32) of FGF8b and a hydrophobic groove within Ig domain 3 of the receptor that is also present in FGFR1c, FGFR3c, and FGFR4. Consistent with the structure, mutation of F32 to alanine reduces the affinity of FGF8b toward all these receptors to levels characteristic of FGF8a. More importantly, analysis of the mid-hindbrain patterning ability of the FGF8b{sup F32A} mutant in chick embryos and murine midbrain explants shows that this mutation functionally converts FGF8b to FGF8a. Moreover, our data suggest that the intermediate receptor-binding affinities of FGF17b and FGF18, relative to FGF8a and FGF8b, also account for the distinct patterning abilities of these two ligands. We also show that the mode of FGF8 receptor-binding specificity is distinct from that of other FGFs and provide the first biochemical evidence for a physiological FGF8b-FGFR1c interaction during mid-hindbrain development. Consistent with the indispensable role of FGF8 in embryonic development, we show that the FGF8 mode of receptor binding appeared as early as in nematodes and has been preserved throughout evolution.« less

Alternating event processes during lifetimes: population dynamics and statistical inference.

PubMed

Shinohara, Russell T; Sun, Yifei; Wang, Mei-Cheng

2018-01-01

In the literature studying recurrent event data, a large amount of work has been focused on univariate recurrent event processes where the occurrence of each event is treated as a single point in time. There are many applications, however, in which univariate recurrent events are insufficient to characterize the feature of the process because patients experience nontrivial durations associated with each event. This results in an alternating event process where the disease status of a patient alternates between exacerbations and remissions. In this paper, we consider the dynamics of a chronic disease and its associated exacerbation-remission process over two time scales: calendar time and time-since-onset. In particular, over calendar time, we explore population dynamics and the relationship between incidence, prevalence and duration for such alternating event processes. We provide nonparametric estimation techniques for characteristic quantities of the process. In some settings, exacerbation processes are observed from an onset time until death; to account for the relationship between the survival and alternating event processes, nonparametric approaches are developed for estimating exacerbation process over lifetime. By understanding the population dynamics and within-process structure, the paper provide a new and general way to study alternating event processes.

Ranking Schools' Academic Performance Using a Fuzzy VIKOR

NASA Astrophysics Data System (ADS)

Musani, Suhaina; Aziz Jemain, Abdul

2015-06-01

Determination rank is structuring alternatives in order of priority. It is based on the criteria determined for each alternative involved. Evaluation criteria are performed and then a composite index composed of each alternative for the purpose of arranging in order of preference alternatives. This practice is known as multiple criteria decision making (MCDM). There are several common approaches to MCDM, one of the practice is known as VIKOR (Multi-criteria Optimization and Compromise Solution). The objective of this study is to develop a rational method for school ranking based on linguistic information of a criterion. The school represents an alternative, while the results for a number of subjects as the criterion. The results of the examination for a course, is given according to the student percentage of each grade. Five grades of excellence, honours, average, pass and fail is used to indicate a level of achievement in linguistics. Linguistic variables are transformed to fuzzy numbers to form a composite index of school performance. Results showed that fuzzy set theory can solve the limitations of using MCDM when there is uncertainty problems exist in the data.

HPLC retention thermodynamics of grape and wine tannins.

PubMed

Barak, Jennifer A; Kennedy, James A

2013-05-08

The effect of grape and wine tannin structure on retention thermodynamics under reversed-phase high-performance liquid chromatography conditions on a polystyrene divinylbenzene column was investigated. On the basis of retention response to temperature, an alternative retention factor was developed to approximate the combined temperature response of the complex, unresolvable tannin mixture. This alternative retention factor was based upon relative tannin peak areas separated by an abrupt change in solvent gradient. Using this alternative retention factor, retention thermodynamics were calculated. Van't Hoff relationships of the natural log of the alternative retention factor against temperature followed Kirchoff's relationship. An inverse quadratic equation was fit to the data, and from this the thermodynamic parameters for tannin retention were calculated. All tannin fractions exhibited exothermic, spontaneous interaction, with enthalpy-entropy compensation observed. Normalizing for tannin size, distinct tannin compositional effects on thermodynamic parameters were observed. The results of this study indicate that HPLC can be valuable for measuring the thermodynamics of tannin interaction with a hydrophobic surface and provides a potentially valuable alternative to calorimetry. Furthermore, the information gathered may provide insight into understanding red wine astringency quality.

Cultural factors in the origin and remediation of alternative conceptions in physics

NASA Astrophysics Data System (ADS)

Thijs, Gerard D.; van den Berg, Ed

1995-10-01

Over a wide range of subject areas students exhibit persistent conceptions contrary to the prevailing scientific concepts. The same alternative conceptions in physics are reported to exist across many countries, within a variety of cultural and environmental contexts. Also, many alternative conceptions show striking similarities with difficulties encountered in the historical development of physics. What is the reason for these similarities? Is intuitive science learned or triggered? And, if similar brain structures are responsible for common-sense theories, in what way then are cultural factors still important in the teaching-learning process? The influence of cultural factors will be discussed on the basis of literature available on this topic. Data collected by the authors in the Netherlands, Indonesia and countries in Africa are also taken into consideration. A distinction is proposed between alternative conceptions some of which may be universal and some dependent on culture. The same distinction is made regarding ways of reasoning and epistemology. It is suggested that the effectiveness of methods for the remediation of alternative conceptions is strongly influenced by cultural aspects of the teaching-learning process.

Virtual-pulse time integral methodology: A new explicit approach for computational dynamics - Theoretical developments for general nonlinear structural dynamics

NASA Technical Reports Server (NTRS)

Chen, Xiaoqin; Tamma, Kumar K.; Sha, Desong

1993-01-01

The present paper describes a new explicit virtual-pulse time integral methodology for nonlinear structural dynamics problems. The purpose of the paper is to provide the theoretical basis of the methodology and to demonstrate applicability of the proposed formulations to nonlinear dynamic structures. Different from the existing numerical methods such as direct time integrations or mode superposition techniques, the proposed methodology offers new perspectives and methodology of development, and possesses several unique and attractive computational characteristics. The methodology is tested and compared with the implicit Newmark method (trapezoidal rule) through a nonlinear softening and hardening spring dynamic models. The numerical results indicate that the proposed explicit virtual-pulse time integral methodology is an excellent alternative for solving general nonlinear dynamic problems.

NASA's activities in the conservation of strategic aerospace materials

NASA Technical Reports Server (NTRS)

Stephens, J. R.

1980-01-01

The United States imports 50-100 percent of certain metals critical to the aerospace industry, namely, cobalt, columbium, chromium, and tantalum. In an effort to reduce this dependence on foreign sources, NASA is planning a program called Conservation of Strategic Aerospace Materials (COSAM), which will provide technology minimizing strategic metal content in the components of aerospace structures such as aircraft engines. With a proposed starting date of October 1981, the program will consist of strategic element substitution, process technology development, and alternate materials research. NASA's two-fold pre-COSAM studies center on, first, substitution research involving nickel-base and cobalt-base superalloys (Waspaloy, Udimet-700, MAE-M247, Rene 150, HA-188) used in turbine disks, low-pressure blades, turbine blades, and combustors; and, second, alternate materials research devoted initially to investigating possible structural applications of the intermetallic alloys nickel aluminide and iron aluminide.

Space Station needs, attributes and architectural options, volume 2, book 3: Cost and programmatics

NASA Technical Reports Server (NTRS)

1983-01-01

The cost and programmatic considerations which integrate mission requirements and architectural options into a cohesive system for exploitation of space opportunities within affordable limits are discussed. The mission requirements, baseline architecture, a top level baseline schedule, and acquisition costs are summarized. The work breakdown structure (WBS) used to structure the program, and the WBS dictionary are included. The costing approach used, including the operation of the primary costing tool, the SPACE cost model are described. The rationale for the choice of cost estimating relationships is given and costs at the module level are shown. Detailed costs at the subsystem level are shown. The baseline schedule and annual funding profiles are provided. Alternate schedules are developed to provide different funding profiles. Alternate funding sources are discussed and foreign and contractor participation is outlined. The results of the benefit analysis are given and the accrued benefits deriving from an implemented space station program are outlined.

Are Public-Private Partnerships an Appropriate Governance Structure for Power Plants? A Transaction Cost Analysis

NASA Astrophysics Data System (ADS)

Ho, S. Ping; Hsu, Yaowen

2015-04-01

In order to meet the requirements of the rapid economic growth, many countries demand an increasing number of power plants to meet the increasing electricity usage. Since high capital requirements of power plants present a big issue for these countries, PPPs have been considered an alternative to provide power plant infrastructure. In particular, in emerging or developing countries, PPPs may be the fastest way to provide the infrastructure needed. However, while PPPs are a promising alternative to providing various types of infrastructure, many failed power plant PPP projects have made it evident that PPPs, under certain situations, can be very costly or even a wrong choice of governance structure. While the higher efficiency due to better pooling of resources is greatly emphasized in Public-Private Partnerships (PPPs), the embedded transaction inefficiencies are often understated or even ignored. Through the lens of Transaction Cost Economics (TCE), this paper aims to answer why and when PPPs may become a costly governance structure for power plants. Specifically, we develop a TCE-based theory of PPPs as a governance structure. This theory suggests that three major opportunism problems embedded in infrastructure PPPs are possible to cause substantial transaction costs and render PPPs a costly governance structure. The three main opportunism problems are principal-principal problem, firm's hold-up problem, and government-led hold-up problem. Moreover, project and institutional characteristics that may lead to opportunism problems are identified. Based on these characteristics, an opportunism-focused transaction cost analysis (OTCA) for PPPs as a governance structure is proposed to supplement the current practice of PPP feasibility analysis. As a part of theory development, a case study of PPP power plants is performed to evaluate the proposed theory and to illustrate how the proposed OTCA can be applied in practice. Policies and administration strategies for power plant PPPs are derived based on the proposed theory.

Freshwater Planarians as an Alternative Animal Model for Neurotoxicology.

PubMed

Hagstrom, Danielle; Cochet-Escartin, Olivier; Zhang, Siqi; Khuu, Cindy; Collins, Eva-Maria S

2015-09-01

Traditional toxicology testing has relied on low-throughput, expensive mammalian studies; however, timely testing of the large number of environmental toxicants requires new in vitro and in vivo platforms for inexpensive medium- to high-throughput screening. Herein, we describe the suitability of the asexual freshwater planarian Dugesia japonica as a new animal model for the study of developmental neurotoxicology. As these asexual animals reproduce by binary fission, followed by regeneration of missing body structures within approximately 1 week, development and regeneration occur through similar processes allowing us to induce neurodevelopment "at will" through amputation. This short time scale and the comparable sizes of full and regenerating animals enable parallel experiments in adults and developing worms to determine development-specific aspects of toxicity. Because the planarian brain, despite its simplicity, is structurally and molecularly similar to the mammalian brain, we are able to ascertain neurodevelopmental toxicity that is relevant to humans. As a proof of concept, we developed a 5-step semiautomatic screening platform to characterize the toxicity of 9 known neurotoxicants (consisting of common solvents, pesticides, and detergents) and a neutral agent, glucose, and quantified effects on viability, stimulated and unstimulated behavior, regeneration, and brain structure. Comparisons of our findings with other alternative toxicology animal models, such as zebrafish larvae and nematodes, demonstrated that planarians are comparably sensitive to the tested chemicals. In addition, we found that certain compounds induced adverse effects specifically in developing animals. We thus conclude that planarians offer new complementary opportunities for developmental neurotoxicology animal models. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Using micro-simulation to investigate the safety impacts of transit design alternatives at signalized intersections.

PubMed

Li, Lu; Persaud, Bhagwant; Shalaby, Amer

2017-03-01

This study investigates the use of crash prediction models and micro-simulation to develop an effective surrogate safety assessment measure at the intersection level. With the use of these tools, hypothetical scenarios can be developed and explored to evaluate the safety impacts of design alternatives in a controlled environment, in which factors not directly associated with the design alternatives can be fixed. Micro-simulation models are developed, calibrated, and validated. Traffic conflicts in the micro-simulation models are estimated and linked with observed crash frequency, which greatly alleviates the lengthy time needed to collect sufficient crash data for evaluating alternatives, due to the rare and infrequent nature of crash events. A set of generalized linear models with negative binomial error structure is developed to correlate the simulated conflicts with the observed crash frequency in Toronto, Ontario, Canada. Crash prediction models are also developed for crashes of different impact types and for transit-involved crashes. The resulting statistical significance and the goodness-of-fit of the models suggest adequate predictive ability. Based on the established correlation between simulated conflicts and observed crashes, scenarios are developed in the micro-simulation models to investigate the safety effects of individual transit line elements by making hypothetical modifications to such elements and estimating changes in crash frequency from the resulting changes in conflicts. The findings imply that the existing transit signal priority schemes can have a negative effect on safety performance, and that the existing near-side stop positioning and streetcar transit type can be safer at their current state than if they were to be replaced by their respective counterparts. Copyright © 2017 Elsevier Ltd. All rights reserved.

Decision making in high-velocity environments: implications for healthcare.

PubMed

Stepanovich, P L; Uhrig, J D

1999-01-01

Healthcare can be considered a high-velocity environment and, as such, can benefit from research conducted in other industries regarding strategic decision making. Strategic planning is not only relevant to firms in high-velocity environments, but is also important for high performance and survival. Specifically, decision-making speed seems to be instrumental in differentiating between high and low performers; fast decision makers outperform slow decision makers. This article outlines the differences between fast and slow decision makers, identifies five paralyses that can slow decision making in healthcare, and outlines the role of a planning department in circumventing these paralyses. Executives can use the proposed planning structure to improve both the speed and quality of strategic decisions. The structure uses planning facilitators to avoid the following five paralyses: 1. Analysis. Decision makers can no longer afford the luxury of lengthy, detailed analysis but must develop real-time systems that provide appropriate, timely information. 2. Alternatives. Many alternatives (beyond the traditional two or three) need to be considered and the alternatives must be evaluated simultaneously. 3. Group Think. Decision makers must avoid limited mind-sets and autocratic leadership styles by seeking out independent, knowledgeable counselors. 4. Process. Decision makers need to resolve conflicts through "consensus with qualification," as opposed to waiting for everyone to come on board. 5. Separation. Successful implementation requires a structured process that cuts across disciplines and levels.

Sorbent Structural Impacts Due to Humidity on Carbon Dioxide Removal Sorbents for Advanced Exploration Systems

NASA Technical Reports Server (NTRS)

Watson, David; Knox, James C.; West, Phillip; Stanley, Christine M.; Bush, Richard

2015-01-01

The Life Support Systems Project (LSSP) under the Advanced Exploration Systems (AES) program builds upon the work performed under the AES Atmosphere Resource Recovery and Environmental Monitoring (ARREM) project focusing on the numerous technology development areas. The CO2 removal and associated air drying development efforts are focused on improving the current state-of-the-art system on the International Space Station (ISS) utilizing fixed beds of sorbent pellets by seeking more robust pelletized sorbents, evaluating structured sorbents, and examining alternate bed configurations to improve system efficiency and reliability. A component of the CO2 removal effort encompasses structural stability testing of existing and emerging sorbents. Testing will be performed on dry sorbents and sorbents that have been conditioned to three humidity levels. This paper describes the sorbent structural stability screening efforts in support of the LSS Project within the AES Program.

A Conceptual framework of Strategy, Structure and Innovative Behaviour for the Development of a Dynamic Simulation Model

NASA Astrophysics Data System (ADS)

Konstantopoulos, Nikolaos; Trivellas, Panagiotis; Reklitis, Panagiotis

2007-12-01

According to many researchers of organizational theory, a great number of problems encountered by the manufacturing firms are due to their failure to foster innovative behaviour by aligning business strategy and structure. From this point of view, the fit between strategy and structure is essential in order to facilitate firms' innovative behaviour. In the present paper, we adopt Porter's typology to operationalise business strategy (cost leadership, innovative and marketing differentiation, and focus). Organizational structure is built on four dimensions (centralization, formalization, complexity and employees' initiatives to implement new ideas). Innovativeness is measured as product innovation, process and technological innovation. This study provides the necessary theoretical framework for the development of a dynamic simulation method, although the simulation of social events is a quite difficult task, considering that there are so many alternatives (not all well understood).

Bayesian Factor Analysis as a Variable Selection Problem: Alternative Priors and Consequences

PubMed Central

Lu, Zhao-Hua; Chow, Sy-Miin; Loken, Eric

2016-01-01

Factor analysis is a popular statistical technique for multivariate data analysis. Developments in the structural equation modeling framework have enabled the use of hybrid confirmatory/exploratory approaches in which factor loading structures can be explored relatively flexibly within a confirmatory factor analysis (CFA) framework. Recently, a Bayesian structural equation modeling (BSEM) approach (Muthén & Asparouhov, 2012) has been proposed as a way to explore the presence of cross-loadings in CFA models. We show that the issue of determining factor loading patterns may be formulated as a Bayesian variable selection problem in which Muthén and Asparouhov’s approach can be regarded as a BSEM approach with ridge regression prior (BSEM-RP). We propose another Bayesian approach, denoted herein as the Bayesian structural equation modeling with spike and slab prior (BSEM-SSP), which serves as a one-stage alternative to the BSEM-RP. We review the theoretical advantages and disadvantages of both approaches and compare their empirical performance relative to two modification indices-based approaches and exploratory factor analysis with target rotation. A teacher stress scale data set (Byrne, 2012; Pettegrew & Wolf, 1982) is used to demonstrate our approach. PMID:27314566

A novel washing algorithm for underarm stain removal

NASA Astrophysics Data System (ADS)

Acikgoz Tufan, H.; Gocek, I.; Sahin, U. K.; Erdem, I.

2017-10-01

After contacting with human sweat which comprise around 27% sebum, anti-perspirants comprising aluminium chloride or its compounds form a jel-like structure whose solubility in water is very poor. In daily use, this jel-like structure closes sweat pores and hinders wetting of skin by sweat. However, when in contact with garments, they form yellowish stains at the underarm of the garments. These stains are very hard to remove with regular machine washing. In this study, first of all, we focused on understanding and simulating such stain formation on the garments. Two alternative procedures are offered to form jel-like structures. On both procedures, commercially available spray or deo-stick type anti-perspirants, standard acidic and basic sweat solutions and artificial sebum are used to form jel-like structures, and they are applied on fabric in order to get hard stains. Secondly, after simulation of the stain on the fabric, we put our efforts on developing a washing algorithm specifically designed for removal of underarm stains. Eight alternative washing algorithms are offered with varying washing temperature, amounts of detergent, and pre-stain removal procedures. Better algorithm is selected by comparison of Tristimulus Y values after washing.

Optics-Only Calibration of a Neural-Net Based Optical NDE Method for Structural Health Monitoring

NASA Technical Reports Server (NTRS)

Decker, Arthur J.

2004-01-01

A calibration process is presented that uses optical measurements alone to calibrate a neural-net based NDE method. The method itself detects small changes in the vibration mode shapes of structures. The optics-only calibration process confirms previous work that the sensitivity to vibration-amplitude changes can be as small as 10 nanometers. A more practical value in an NDE service laboratory is shown to be 50 nanometers. Both model-generated and experimental calibrations are demonstrated using two implementations of the calibration technique. The implementations are based on previously published demonstrations of the NDE method and an alternative calibration procedure that depends on comparing neural-net and point sensor measurements. The optics-only calibration method, unlike the alternative method, does not require modifications of the structure being tested or the creation of calibration objects. The calibration process can be used to test improvements in the NDE process and to develop a vibration-mode-independence of damagedetection sensitivity. The calibration effort was intended to support NASA s objective to promote safety in the operations of ground test facilities or aviation safety, in general, by allowing the detection of the gradual onset of structural changes and damage.

Alternative materials for FDOT sign structures : phase I literature review.

DOT National Transportation Integrated Search

2012-05-01

Inspections of tubular sign structures by the Florida Department of Transportation (FDOT) have : revealed occurrences of premature corrosion on the inside of galvanized steel tubes. As a result, FDOT : engineers are seeking alternative materials that...

Time, space, and disorder in the expanding proteome universe.

PubMed

Minde, David-Paul; Dunker, A Keith; Lilley, Kathryn S

2017-04-01

Proteins are highly dynamic entities. Their myriad functions require specific structures, but proteins' dynamic nature ranges all the way from the local mobility of their amino acid constituents to mobility within and well beyond single cells. A truly comprehensive view of the dynamic structural proteome includes: (i) alternative sequences, (ii) alternative conformations, (iii) alternative interactions with a range of biomolecules, (iv) cellular localizations, (v) alternative behaviors in different cell types. While these aspects have traditionally been explored one protein at a time, we highlight recently emerging global approaches that accelerate comprehensive insights into these facets of the dynamic nature of protein structure. Computational tools that integrate and expand on multiple orthogonal data types promise to enable the transition from a disjointed list of static snapshots to a structurally explicit understanding of the dynamics of cellular mechanisms. © 2017 The Authors. Proteomics Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Using an Enhanced Conflict Map in the Classroom (Photoelectric Effect) Based on Lakatosian Heuristic Principle Strategies

ERIC Educational Resources Information Center

Oh, Jun-Young

2011-01-01

Researchers have shown that most students resist changes to their core beliefs by offering auxiliary hypotheses at the first sign of the development of conceptual change. Studies have viewed student reaction to discrepant events as an important clue in helping researchers understand not only the structure of alternative concepts (Niaz,…

Lactic Acid Bacteria – Friend or Foe? Lactic Acid Bacteria in the Production of Polysaccharides and Fuel Ethanol

USDA-ARS?s Scientific Manuscript database

Lactic acid bacteria (LAB) have been widely used in the production of fermented foods and as probiotics. Alternan is a glucan with a distinctive backbone structure of alternating a-(1,6) and a-(1,3) linkages produced by the LAB Leuconostoc mesenteroides. In recent years, we have developed improved...

Transcriptional control by G-quadruplexes: In vivo roles and perspectives for specific intervention.

PubMed

Armas, Pablo; David, Aldana; Calcaterra, Nora B

2017-01-01

G-quadruplexes are non-canonical DNA secondary structures involved in several genomic and molecular processes. Here, we summarize the main G-quadruplex features and evidences proving the in vivo role on the transcriptional regulation of genes required for zebrafish embryonic development. We also discuss alternative strategies for specifically interfering G-quadruplex in vivo.

[Selected problems of manufacturing influenza vaccines].

PubMed

Augustynowicz, Ewa

2010-01-01

In the study chosen issues of manufacturing influenza vaccines running to increase effectiveness were performed. New concepts into development of process of safety and efficacy influenza vaccines are connected with use a new adjuvants, use of alternative routes of administration of vaccine, new structural virus subunits including DNA, new way of virus culture and use of live, attenuated vaccines.

Short-term responses of overstory and understory vegetation to thinning treatments: a tale of two studies

Treesearch

Klaus J. Puettmann; Erich Kyle Dodson; Adrian Ares; Carrie A. Berger

2013-01-01

The Density Management Study and Young Stand Th inning and Diversity Study were initiated to investigate whether alternative thinning treatments can accelerate the development of forests toward late-successional structures. An overview of overstory and understory vegetation responses indicates that the magnitude and direction of thinning eff ects initially varied among...

European Scientific Notes. Volume 37, Numbers 12.

DTIC Science & Technology

1983-12-01

Hamburg during August. This article highlights some of the papers dealing with oceano- graphy, geology, and geophysics. ENERGY Egypt’s Energy Crisis...little progress in developing alternative sources of energy . ENGINEERING Leeds-Lyon Tribology Conference ................................. Harold’G...probe the structure of the electric field in collective ion acceleration experiments. Energy -Transfer Processes in Condensed Matter

Songbird response to alternative forest density management in young Douglas-fir stands

Treesearch

Joan C. Hagar

2013-01-01

Th inning has been increasingly used in the Pacifi c Northwest to restore structural and biological diversity to densely-stocked young- to mid-aged forests that have been previously intensively managed for timber production. In the short term, thinning promotes development of understory vegetation, which in turn can increase habitat diversity for wildlife, particularly...

Exploring Commitment to Teaching through Personalized Delivery Systems in an Introductory Education Course.

ERIC Educational Resources Information Center

Bowman, David L.; Weisse, Edward B.

Two instructional models offer alternatives to the traditional lecture-discussion of undergraduate teacher aspirants. A self-paced model is composed of videotaped lectures, a learning package, and the use of both student proctors and instructor contact. Each student must develop his/her own time to be allotted structure for the course. An…

Transcriptome analysis of a Ustilago maydis ust1 deletion mutant uncovers involvement of laccase and polyketide synthase genes in spore development

USDA-ARS?s Scientific Manuscript database

Ustilago maydis, causal agent of corn smut disease, is a dimorphic fungus alternating between a saprobic budding haploid, and an obligate pathogenic filamentous dikaryon. Maize responds to U. maydis colonization by producing tumorous structures, and only within these does the fungus sporulate, produ...

The Dependent Poisson Race Model and Modeling Dependence in Conjoint Choice Experiments

ERIC Educational Resources Information Center

Ruan, Shiling; MacEachern, Steven N.; Otter, Thomas; Dean, Angela M.

2008-01-01

Conjoint choice experiments are used widely in marketing to study consumer preferences amongst alternative products. We develop a class of choice models, belonging to the class of Poisson race models, that describe a "random utility" which lends itself to a process-based description of choice. The models incorporate a dependence structure which…

Potential Alternatives Report for Validation of Alternative Low-Emission Surface PreparationlDepainting Technologies for Structural Steel

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2006-01-01

For this project, particulates and solvents used during the depainting process of steel structures were the identified hazardous material (HazMat) targeted for elimination or reduction. This Potential Alternatives Report (PAR) provides technical analyses of identified alternatives to the current coating removal processes, criteria used to select alternatives for further analysis, and a list of those alternatives recommended for testing. The initial coating removal alternatives list was compiled using literature searches and center participant recommendations. The involved project participants initially considered fifteen (15) alternatives. In late 2004, stakeholders down-selected the list and identified specific processes as potential alternatives to the current depainting methods. The selected alternatives were: 1. Plastic Blast Media 2. Hard Abrasive Media 3. Sponge Blast Media 4. Mechanical Removal with Vacuum Attachment 5. Liquid Nitrogen 6. Laser Coating Removal Available information about these processes was used to analyze the technical merits and the potential environmental, safety, and occupational health (ESOH) impacts of these methods. A preliminary cost benefit analysis will be performed to determine if implementation of alternative technologies is economically justified. NASA AP2

G-quadruplex in animal development: Contribution to gene expression and genomic heterogeneity.

PubMed

Armas, Pablo; Calcaterra, Nora Beatriz

2018-05-18

During animal development, gene expression is orchestrated by specific and highly evolutionarily conserved mechanisms that take place accurately, both at spatial and temporal levels. The last decades have provided compelling evidence showing that chromatin state plays essential roles in orchestrating most of the stages of development. The DNA molecule can adopt alternative structures different from the helical duplex architecture. G-rich DNA sequences can fold as intrastrand quadruple helix structures called G-quadruplexes or G4-DNA. G4 can also be formed in RNA molecules, such as mRNA, lncRNA and pre-miRNA. Emerging evidences suggest that G4s have crucial roles in a variety of biological processes, including transcription, recombination, replication, translation and chromosome stability. In this review, we have collected recent information gathered by various laboratories showing the important role of G4 DNA and RNA structures in several steps of animal development. Copyright © 2018 Elsevier B.V. All rights reserved.

Self-organization of maze-like structures via guided wrinkling.

PubMed

Bae, Hyung Jong; Bae, Sangwook; Yoon, Jinsik; Park, Cheolheon; Kim, Kibeom; Kwon, Sunghoon; Park, Wook

2017-06-01

Sophisticated three-dimensional (3D) structures found in nature are self-organized by bottom-up natural processes. To artificially construct these complex systems, various bottom-up fabrication methods, designed to transform 2D structures into 3D structures, have been developed as alternatives to conventional top-down lithography processes. We present a different self-organization approach, where we construct microstructures with periodic and ordered, but with random architecture, like mazes. For this purpose, we transformed planar surfaces using wrinkling to directly use randomly generated ridges as maze walls. Highly regular maze structures, consisting of several tessellations with customized designs, were fabricated by precisely controlling wrinkling with the ridge-guiding structure, analogous to the creases in origami. The method presented here could have widespread applications in various material systems with multiple length scales.

Model structure of the stream salmonid simulator (S3)—A dynamic model for simulating growth, movement, and survival of juvenile salmonids

USGS Publications Warehouse

Perry, Russell W.; Plumb, John M.; Jones, Edward C.; Som, Nicholas A.; Hetrick, Nicholas J.; Hardy, Thomas B.

2018-04-06

Fisheries and water managers often use population models to aid in understanding the effect of alternative water management or restoration actions on anadromous fish populations. We developed the Stream Salmonid Simulator (S3) to help resource managers evaluate the effect of management alternatives on juvenile salmonid populations. S3 is a deterministic stage-structured population model that tracks daily growth, movement, and survival of juvenile salmon. A key theme of the model is that river flow affects habitat availability and capacity, which in turn drives density dependent population dynamics. To explicitly link population dynamics to habitat quality and quantity, the river environment is constructed as a one-dimensional series of linked habitat units, each of which has an associated daily time series of discharge, water temperature, and usable habitat area or carrying capacity. The physical characteristics of each habitat unit and the number of fish occupying each unit, in turn, drive survival and growth within each habitat unit and movement of fish among habitat units.The purpose of this report is to outline the underlying general structure of the S3 model that is common among different applications of the model. We have developed applications of the S3 model for juvenile fall Chinook salmon (Oncorhynchus tshawytscha) in the lower Klamath River. Thus, this report is a companion to current application of the S3 model to the Trinity River (in review). The general S3 model structure provides a biological and physical framework for the salmonid freshwater life cycle. This framework captures important demographics of juvenile salmonids aimed at translating management alternatives into simulated population responses. Although the S3 model is built on this common framework, the model has been constructed to allow much flexibility in application of the model to specific river systems. The ability for practitioners to include system-specific information for the physical stream structure, survival, growth, and movement processes ensures that simulations provide results that are relevant to the questions asked about the population under study.

High resolution TEM and 3D imaging of polymer-based and dye-sensitized solar cells

NASA Astrophysics Data System (ADS)

Suh, Youngjoon

Since 1950s, solar energy has been the most attractive energy source as an alternative to fossil fuels including oil and natural gas. However, these types of solar cells have high raw material and manufacturing costs. So, alternative solar cells using low cost materials and manufacturing processes have been actively studied for more than 10 years. The power conversion efficiency of some of the alternative solar cells has been recently improved so much as to be used for real life applications in the near future. However, their relatively short lifetime still remains as a bottleneck in their commercialized use. In this dissertation, we studied cross sections of three types of solar cells using TEM micrographs and TEM related analysis methods; selected area diffraction, energy dispersive spectroscopy, electron tomography, and nanobeam diffraction. A thin Ag layer used for a top metal electrode in an inverted polymer solar cell was broken down into particles. Absorption of water by the PEDOT:PSS layer followed by corrosion of the Ag layer was thought to be the main cause of this phenomenon. The structure and materials of the photoactive layer in hybrid polymer solar cells have an important influence on the performance of the solar cell devices. Three kinds of efforts were made to improve the electrical characteristics of the devices; removal of a dark TiO2 layer at the polymer/TiO2 interface, using bulk heterojunction structures, and coating a fullerene interlayer on the inorganic nanostructure. An optimum concentration of carbon nanotubes (CNTs) combined with Ru could increase the interface area of CNTs, and improve the performances of dye sensitized solar cells. In order to develop plastic solar cell, two different methods of mixing TiO2 particles with either nanoglues or PMMA were tried. Cross-sectional TEM microstructures were examined to come up with optimum processing parameters such as the sintering temperature and the amount of PMMA added into the structure. Cross-sectional TEM and electron tomography have been very useful for developing new kinds of solar cell structures as well as finding various defects in the structures.

Precision hole punching on composite fiber reinforced polymer panels

NASA Astrophysics Data System (ADS)

Abdullah, A. B.; Zain, M. S. M.; Chan, H. Y.; Samad, Z.

2017-12-01

Structural materials, such as composite panels, can only be assembled, and in most cases through the use of fasteners, which are fitted into the drilled holes. However, drilling is costly and time consuming, thus affecting productivity. This research aims to develop an alternative method to drilling. In this paper, the precision of the holes was measured and the effects of the die clearance to the areas around the holes were evaluated. Measurement and evaluation were performed based on the profile of the holes constructed using Alicona IFM, a 3D surface measurement technique. Results showed that punching is a potential alternative to drilling but still requires improvements.

Development of a Novel, Low-Cost, Disposable Wooden Pencil Graphite Electrode for Use in the Determination of Antioxidants and Other Biological Compounds.

PubMed

Kariuki, James; Ervin, Emily; Olafson, Carly

2015-07-31

The development of portable sensors that can be used outside the lab is an active area of research in the electroanalytical field. A major focus of such research is the development of low-cost electrodes for use in these sensors. Current electrodes, such as glassy-carbon electrodes (GCEs), are costly and require time-consuming preparation. Alternatives have been proposed, including mechanical pencil-lead electrodes (MPEs). However, MPEs themselves possess numerous drawbacks, particularly structural fragility. In this paper, we present a novel pencil-graphite electrode (PGE) fabricated from a regular HB#2 pencil. This PGE is a simple, disposable, extremely low-cost alternative to GCEs ($0.30 per PGE, vs. $190 + per GCE), and possesses the structural stability that MPEs lack. PGEs were characterized by square-wave voltammetry of ferricyanide, gallic acid, uric acid, dopamine, and several foodstuffs. In all cases, PGEs demonstrated sensitivities comparable or superior to those of the GCE and MPE (LOD = 5.62 × 10(-4) M PGE, 4.80 × 10(-4) M GCE, 2.93 × 10(-4) M MPE). Signal areas and peak heights were typically four to ten times larger for the PGE relative to the GCE.

A Case Study on Hydrodynamic Modeling and Design Improvement Evaluation to Manage Debris and Sediment Interference at a Water Intake Structure

NASA Astrophysics Data System (ADS)

Crissman, B. J.; Cunderlik, J. M.; Wong, R. P. L.; Pinero, A.

2017-12-01

Waterford 3 nuclear plant, located in Killona, Louisiana, provides approximately 10% of the state's electricity need. Located along the south bank of the Mississippi River, two miles upstream of the Bonnet Carre Spillway, the plant's single pass through cooling system continuously draws up to 1,000,000 gpm water from the river. On behalf of Entergy Louisiana, the project team evaluated options to improve the aging water intake structure with chronic debris and sediment entrainment issues. The highly complex and dynamic environment in the river coupled with regulatory constraints limited available improvement options: varying river stages allow debris to overflow the intake structure, but the maximum new wall height is restricted to minimize aesthetic intrusion and alteration to levee tie-back; bow waves push debris into the downstream intake wall, but the wall needs to maintain an opening to flush debris out from the intake structure; the river delivers significant sediment load, but any proposed intake structure cannot significantly alter existing bathymetry; EPA Clean Water Act Section 316(b) limited maximum velocity at the intake structure to 0.5 fps for entrainment prevention. To expedite alternative evaluation while providing sufficient data to inform management decision, instead of developing physical models, the project team developed a two-tier approach utilizing the TELEMAC hydrodynamic program to prepare screening analysis in 2D modeling and final evaluation in 3D modeling. The model was built upon the USACE ERDC ADH model, calibrated with river gauge data and peer reviewed by ERDC. TELEMAC, developed by EDF, provides novel features for modeling improvement options, including the recommended design concept, which is a hydraulically optimized intake geometry configured to maintain uniform intake flow while streamlining river flowline for debris and sediment deflection. The design includes submerged inlets with upstream and downstream walls to block floating debris and bed load movement, large intake screens to reduce velocity, and a log-boom debris deflection system that floats with the river level. This project demonstrated a time and cost efficient approach to develop reliable solutions and hydrodynamic data describing design alternatives performance.

What can alienation theory contribute to an understanding of social inequalities in health?

PubMed

Crinson, Iain; Yuill, Chris

2008-01-01

This article examines both the contribution and the limitations of research that has sought to develop a causal understanding of the psychosocial dimension of inequalities in health. The article seeks to revive interest in Marx's theory of alienation in developing the case for an alternative materialist conceptualization that is able to postulate the pathways from alienation as a psychosocial generative structure to social inequalities in health outcomes within late modern societies.

Development of mini VSAT system

NASA Astrophysics Data System (ADS)

Lu, Shyue-Ching; Chiu, Wu-Jhy; Lin, Hen-Dao; Shih, Mu-Piao

1992-03-01

This paper presents the mini VSAT (very small aperture terminal) system, which is a low cost networking system providing economical alternatives to the business world's datacom needs. The system is designed to achieve the highest possible performance/price ratio for private VSAT networks that range from a few tens of remote terminals to large networks of several thousands remote terminals. The paper describes the system architecture, major features, hardware and software structure, access protocol and performance of the developed system.

Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystem Concepts. Volume 1; Executive Summary

NASA Technical Reports Server (NTRS)

Levack, Daniel J. H.

2000-01-01

The Alternate Propulsion Subsystem Concepts contract had seven tasks defined that are reported under this contract deliverable. The tasks were: FAA Restart Study, J-2S Restart Study, Propulsion Database Development. SSME Upper Stage Use. CERs for Liquid Propellant Rocket Engines. Advanced Low Cost Engines, and Tripropellant Comparison Study. The two restart studies, F-1A and J-2S, generated program plans for restarting production of each engine. Special emphasis was placed on determining changes to individual parts due to obsolete materials, changes in OSHA and environmental concerns, new processes available, and any configuration changes to the engines. The Propulsion Database Development task developed a database structure and format which is easy to use and modify while also being comprehensive in the level of detail available. The database structure included extensive engine information and allows for parametric data generation for conceptual engine concepts. The SSME Upper Stage Use task examined the changes needed or desirable to use the SSME as an upper stage engine both in a second stage and in a translunar injection stage. The CERs for Liquid Engines task developed qualitative parametric cost estimating relationships at the engine and major subassembly level for estimating development and production costs of chemical propulsion liquid rocket engines. The Advanced Low Cost Engines task examined propulsion systems for SSTO applications including engine concept definition, mission analysis. trade studies. operating point selection, turbomachinery alternatives, life cycle cost, weight definition. and point design conceptual drawings and component design. The task concentrated on bipropellant engines, but also examined tripropellant engines. The Tripropellant Comparison Study task provided an unambiguous comparison among various tripropellant implementation approaches and cycle choices, and then compared them to similarly designed bipropellant engines in the SSTO mission This volume overviews each of the tasks giving its objectives, main results. and conclusions. More detailed Final Task Reports are available on each individual task.

Chemical synthetic biology: a mini-review.

PubMed

Chiarabelli, Cristiano; Stano, Pasquale; Luisi, Pier Luigi

2013-01-01

Chemical synthetic biology (CSB) is a branch of synthetic biology (SB) oriented toward the synthesis of chemical structures alternative to those present in nature. Whereas SB combines biology and engineering with the aim of synthesizing biological structures or life forms that do not exist in nature - often based on genome manipulation, CSB uses and assembles biological parts, synthetic or not, to create new and alternative structures. A short epistemological note will introduce the theoretical concepts related to these fields, whereas the text will be largely devoted to introduce and comment two main projects of CSB, carried out in our laboratory in the recent years. The "Never Born Biopolymers" project deals with the construction and the screening of RNA and peptide sequences that are not present in nature, whereas the "Minimal Cell" project focuses on the construction of semi-synthetic compartments (usually liposomes) containing the minimal and sufficient number of components to perform the basic function of a biological cell. These two topics are extremely important for both the general understanding of biology in terms of function, organization, and development, and for applied biotechnology.

An alternative approach for computing seismic response with accidental eccentricity

NASA Astrophysics Data System (ADS)

Fan, Xuanhua; Yin, Jiacong; Sun, Shuli; Chen, Pu

2014-09-01

Accidental eccentricity is a non-standard assumption for seismic design of tall buildings. Taking it into consideration requires reanalysis of seismic resistance, which requires either time consuming computation of natural vibration of eccentric structures or finding a static displacement solution by applying an approximated equivalent torsional moment for each eccentric case. This study proposes an alternative modal response spectrum analysis (MRSA) approach to calculate seismic responses with accidental eccentricity. The proposed approach, called the Rayleigh Ritz Projection-MRSA (RRP-MRSA), is developed based on MRSA and two strategies: (a) a RRP method to obtain a fast calculation of approximate modes of eccentric structures; and (b) an approach to assemble mass matrices of eccentric structures. The efficiency of RRP-MRSA is tested via engineering examples and compared with the standard MRSA (ST-MRSA) and one approximate method, i.e., the equivalent torsional moment hybrid MRSA (ETM-MRSA). Numerical results show that RRP-MRSA not only achieves almost the same precision as ST-MRSA, and is much better than ETM-MRSA, but is also more economical. Thus, RRP-MRSA can be in place of current accidental eccentricity computations in seismic design.

Applying Structural Equation Modeling in the Context of the Theory of Reasoned Action: Some Problems and Solutions.

ERIC Educational Resources Information Center

van den Putte, Bas; Hoogstraten, Johan

1997-01-01

Problems found in the application of structural equation modeling to the theory of reasoned action are explored, and an alternative model specification is proposed that improves the fit of the data while leaving intact the structural part of the model being tested. Problems and the proposed alternative are illustrated. (SLD)

Metropolitan Washington Area Water Supply Study. Appendix C. Public Involvement.

DTIC Science & Technology

1983-09-01

identi- fy and evaluate alternative methods of alleviating future deficits. Initiated in 1976, the study was conducted in two phases over a 7-year...analysis of +he full spectrum of structural and nonstructural water supply alternati’, s. In addition to such traditional water supply alternatives as...Investigation, Occoquan Interconnection Interconnections and Comparison Reregulation Structural Alternatives F-I Digital Simulation of Groundwater Flow in Part of

Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases

PubMed Central

Ortigão-Farias, João Ramalho; Di-Blasi, Tatiana; Telleria, Erich Loza; Andorinho, Ana Carolina; Lemos-Silva, Thais; Ramalho-Ortigão, Marcelo; Tempone, Antônio Jorge; Traub-Csekö, Yara Maria

2018-01-01

BACKGROUND The insect chitinase gene family is composed by more than 10 paralogs, which can codify proteins with different domain structures. In Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil, a chitinase cDNA from adult female insects was previously characterized. The predicted protein contains one catalytic domain and one chitin-binding domain (CBD). The expression of this gene coincided with the end of blood digestion indicating a putative role in peritrophic matrix degradation. OBJECTIVES To determine the occurrence of alternative splicing in chitinases of L. longipalpis. METHODS We sequenced the LlChit1 gene from a genomic clone and the three spliced forms obtained by reverse transcription polymerase chain reaction (RT-PCR) using larvae cDNA. FINDINGS We showed that LlChit1 from L. longipalpis immature forms undergoes alternative splicing. The spliced form corresponding to the adult cDNA was named LlChit1A and the two larvae specific transcripts were named LlChit1B and LlChit1C. The B and C forms possess stop codons interrupting the translation of the CBD. The A form is present in adult females post blood meal, L4 larvae and pre-pupae, while the other two forms are present only in L4 larvae and disappear just before pupation. Two bands of the expected size were identified by Western blot only in L4 larvae. MAIN CONCLUSIONS We show for the first time alternative splicing generating chitinases with different domain structures increasing our understanding on the finely regulated digestion physiology and shedding light on a potential target for controlling L. longipalpis larval development. PMID:29236932

Bridge maintenance to enhance corrosion resistance and performance of steel girder bridges

NASA Astrophysics Data System (ADS)

Moran Yanez, Luis M.

The integrity and efficiency of any national highway system relies on the condition of the various components. Bridges are fundamental elements of a highway system, representing an important investment and a strategic link that facilitates the transport of persons and goods. The cost to rehabilitate or replace a highway bridge represents an important expenditure to the owner, who needs to evaluate the correct time to assume that cost. Among the several factors that affect the condition of steel highway bridges, corrosion is identified as the main problem. In the USA corrosion is the primary cause of structurally deficient steel bridges. The benefit of regular high-pressure superstructure washing and spot painting were evaluated as effective maintenance activities to reduce the corrosion process. The effectiveness of steel girder washing was assessed by developing models of corrosion deterioration of composite steel girders and analyzing steel coupons at the laboratory under atmospheric corrosion for two alternatives: when high-pressure washing was performed and when washing was not considered. The effectiveness of spot painting was assessed by analyzing the corrosion on steel coupons, with small damages, unprotected and protected by spot painting. A parametric analysis of corroded steel girder bridges was considered. The emphasis was focused on the parametric analyses of corroded steel girder bridges under two alternatives: (a) when steel bridge girder washing is performed according to a particular frequency, and (b) when no bridge washing is performed to the girders. The reduction of structural capacity was observed for both alternatives along the structure service life, estimated at 100 years. An economic analysis, using the Life-Cycle Cost Analysis method, demonstrated that it is more cost-effective to perform steel girder washing as a scheduled maintenance activity in contrast to the no washing alternative.

Mechanical Engineering Department engineering research: Annual report, FY 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Denney, R.M.; Essary, K.L.; Genin, M.S.

1986-12-01

This report provides information on the five areas of research interest in LLNL's Mechanical Engineering Department. In Computer Code Development, a solid geometric modeling program is described. In Dynamic Systems and Control, structure control and structure dynamics are discussed. Fabrication technology involves machine cutting, interferometry, and automated optical component manufacturing. Materials engineering reports on composite material research and measurement of molten metal surface properties. In Nondestructive Evaluation, NMR, CAT, and ultrasound machines are applied to manufacturing processes. A model for underground collapse is developed. Finally, an alternative heat exchanger is investigated for use in a fusion power plant. Separate abstractsmore » were prepared for each of the 13 reports in this publication. (JDH)« less

Prospects for a civil/military transport aircraft

NASA Technical Reports Server (NTRS)

Jobe, C. E.; Noggle, L. W.; Whitehead, A. H., Jr.

1978-01-01

The similarities and disparities between commercial and military payloads, design features, missions, and transport aircraft are enumerated. Two matrices of civil/military transport aircraft designs were evaluated to determine the most cost effective payloads for a projected commercial route structure and air freight market. The probability of this market developing and the prospects for alternate route structures and freight markets are evaluated along with the possible impact on the aircraft designs. Proposals to stimulate the market and increase the viability of the common aircraft concept are reviewed and the possible impact of higher cargo demand on prospects for common civil/military freighters is postulated. The implications of planned advanced technology developments on the aircraft performance and cost are also considered.

Cyclical parthenogenesis algorithm for layout optimization of truss structures with frequency constraints

NASA Astrophysics Data System (ADS)

Kaveh, A.; Zolghadr, A.

2017-08-01

Structural optimization with frequency constraints is seen as a challenging problem because it is associated with highly nonlinear, discontinuous and non-convex search spaces consisting of several local optima. Therefore, competent optimization algorithms are essential for addressing these problems. In this article, a newly developed metaheuristic method called the cyclical parthenogenesis algorithm (CPA) is used for layout optimization of truss structures subjected to frequency constraints. CPA is a nature-inspired, population-based metaheuristic algorithm, which imitates the reproductive and social behaviour of some animal species such as aphids, which alternate between sexual and asexual reproduction. The efficiency of the CPA is validated using four numerical examples.

Relative Displacement Method for Track-Structure Interaction

PubMed Central

Ramos, Óscar Ramón; Pantaleón, Marcos J.

2014-01-01

The track-structure interaction effects are usually analysed with conventional FEM programs, where it is difficult to implement the complex track-structure connection behaviour, which is nonlinear, elastic-plastic and depends on the vertical load. The authors developed an alternative analysis method, which they call the relative displacement method. It is based on the calculation of deformation states in single DOF element models that satisfy the boundary conditions. For its solution, an iterative optimisation algorithm is used. This method can be implemented in any programming language or analysis software. A comparison with ABAQUS calculations shows a very good result correlation and compliance with the standard's specifications. PMID:24634610

Optimal descriptor as a translator of eclectic information into the prediction of membrane damage by means of various TiO(2) nanoparticles.

PubMed

Toropova, Alla P; Toropov, Andrey A

2013-11-01

The increasing use of nanomaterials incorporated into consumer products leads to the need for developing approaches to establish "quantitative structure-activity relationships" (QSARs) for various nanomaterials. However, the molecular structure as rule is not available for nanomaterials at least in its classic meaning. An possible alternative of classic QSAR (based on the molecular structure) is the using of data on physicochemical features of TiO(2) nanoparticles. The damage to cellular membranes (units L(-1)) by means of various TiO(2) nanoparticles is examined as the endpoint. Copyright © 2013 Elsevier Ltd. All rights reserved.

Synthesis and Characterization of SF-PPV-I

NASA Technical Reports Server (NTRS)

Wang, Y.; Fan, Z.; Taft, C.; Sun, S.

2001-01-01

Conjugated electro-active polymers find their potential applications in developing variety inexpensive and flexible shaped electronic and photonic devices, such as photovoltaic or photo/electro light emitting devices. In many of these opto-electronic polymeric materials, certain electron rich donors and electron deficient acceptors are needed in order to fine-tune the electronic or photonic properties of the desired materials and structures. While many donor type of conjugated polymers have been widely studied and developed in the past decades, there are relatively fewer acceptor type of conjugated polymers have been developed. Key acceptor type conjugated polymers developed so far include C60 and CN-PPV, and each has its limitations. Due to the complexity and diversity of variety future electronic materials and structural needs, alternative and synthetically amenable acceptor conjugated polymers need to be developed. In this paper, we present the synthesis and characterization of a new acceptor conjugated polymer, a sulfone derivatized polyphenylenevinylene "SF-PPV".

The picture exchange communication system.

PubMed

Bondy, A S; Frost, L A

1998-01-01

The Picture Exchange Communication System (PECS) was developed as a means to teach children with autism and related developmental disabilities a rapidly acquired, self-initiating, functional communication system. Its theoretical roots combine principles from applied behavior analysis and guidelines established within the field of alternative and augmentative communication. This approach has several potential advantages relative to imitation-based strategies (both vocal and gestural) and symbol selection strategies. The system begins with the exchange of simple icons but rapidly builds "sentence" structure. The system also emphasizes developing the request function prior to developing responding to simple questions and commenting. The development of requesting with a sentence structure also permits the rapid development of attributes more traditionally taught within a receptive mode. The relationship between the introduction of PECS and various other behavioral issues (i.e., social approach and behavior management) as well as its relationship to the codevelopment of speech are reviewed.

Improvement of the organizational and economic mechanism for managing the development of alternative sources of electricity at the territorial level

NASA Astrophysics Data System (ADS)

Kirillova, Ariadna; Krylova, Anna

2017-10-01

The article considers the features of the structure and functioning of energy supply facilities for housing and communal services of municipalities with the identification and analysis of problems, substantiates the main directions of improving the organizational and economic mechanism for the development of alternative sources of electricity supply, taking into account modern innovative energy-efficient technologies. The choice of a rational option for electricity supply to settlements and the region is considered on the basis of an analysis of geographical, climatic and socio-economic conditions, as well as engineering and financial opportunities, the availability of trunk, interregional and other networks, the total installed capacity of regional power plants and a set of other technical and economic Characteristics inherent in the region and its municipalities.

On the global circulation and the hurricane system of the Jovian atmosphere

NASA Technical Reports Server (NTRS)

Mayr, H. G.; Meada, K.; Harris, I.

1981-01-01

An argument is made to support the proposal that Jupiter's red spot and the white and brown ovals are hurricanes or cyclones. Against the background of a convectively unstable troposphere, the general condition exists for the formation of hurricanes. The energy Jupiter emits must be transported upwards through the troposphere. If that transport is accelerated by the prevailing upward motions in the solar driven multicellular meridional circulation, eastward jets develop such as observed in the l region. But if that vertical transport is impeded by the prevailing downward motions in the meridional circulation, the atmosphere reacts and tends to maintain the process through the development of hurricanes. Dynamically induced by solar differential heating, an ordered latitudinal structure with alternating stability and instability is impressed on the troposphere to form alternating zonal strata where hurricanes are forbidden and permitted, respectively.

Evaluation of Laminar Flow Control System Concepts for Subsonic Commercial Transport Aircraft

NASA Technical Reports Server (NTRS)

Sturgeon, R. F.

1980-01-01

Alternatives in the design of laminar flow control (LFC) subsonic commerical transport aircraft for opeation in the 1980's period were studied. Analyses were conducted to select mission parameters and define optimum aircraft configurational parameters for the selected mission, defined by a passenger payload of 400 and a design range of 12, 038 km (6500 n mi). The baseline aircraft developed for this mission was used as a vehicle for the evaluation and development of alternative LFC system concepts. Alternatices in the areas of aerodynamics, structures and materials, LFC systems, leading-edge region cleaning, and integration of auxiliary systems were studied. Relative to a similarly-optimized advanced technology turbulent transport, the final LFC configuration is approximately equal in DOC but provides descreases of 8.2% in gross weight and 21.7% in fuel consumption.

Alternatives in the complement and structure of NASA teleprocessing resources

NASA Technical Reports Server (NTRS)

1972-01-01

The results are presented of a program to identify technical innovations which would have an impact on NASA data processing and describe as fully as possible the development work necessary to exploit them. Seven of these options for NASA development, as the opportunities to participate in and enhance the advancing information system technology were called, are reported. A detailed treatment is given of three of the options, involving minicomputers, mass storage devices and software development techniques. These areas were picked by NASA as having the most potential for improving their operations.

Aspects of Unstructured Grids and Finite-Volume Solvers for the Euler and Navier-Stokes Equations

NASA Technical Reports Server (NTRS)

Barth, Timothy J.

1992-01-01

One of the major achievements in engineering science has been the development of computer algorithms for solving nonlinear differential equations such as the Navier-Stokes equations. In the past, limited computer resources have motivated the development of efficient numerical schemes in computational fluid dynamics (CFD) utilizing structured meshes. The use of structured meshes greatly simplifies the implementation of CFD algorithms on conventional computers. Unstructured grids on the other hand offer an alternative to modeling complex geometries. Unstructured meshes have irregular connectivity and usually contain combinations of triangles, quadrilaterals, tetrahedra, and hexahedra. The generation and use of unstructured grids poses new challenges in CFD. The purpose of this note is to present recent developments in the unstructured grid generation and flow solution technology.

Effects of alternative outcome scenarios and structured outcome evaluation on case-based ethics instruction.

PubMed

Peacock, Juandre; Harkrider, Lauren N; Bagdasarov, Zhanna; Connelly, Shane; Johnson, James F; Thiel, Chase E; Macdougall, Alexandra E; Mumford, Michael D; Devenport, Lynn D

2013-09-01

Case-based instruction has been regarded by many as a viable alternative to traditional lecture-based education and training. However, little is known about how case-based training techniques impact training effectiveness. This study examined the effects of two such techniques: (a) presentation of alternative outcome scenarios to a case, and (b) conducting a structured outcome evaluation. Consistent with the hypotheses, results indicate that presentation of alternative outcome scenarios reduced knowledge acquisition, reduced sensemaking and ethical decision-making strategy use, and reduced decision ethicality. Conducting a structured outcome evaluation had no impact on these outcomes. Results indicate that those who use case-based instruction should take care to use clear, less complex cases with only a singular outcome if they are seeking these types of outcomes.

Preparation and Sound Absorption Properties of a Barium Titanate/Nitrile Butadiene Rubber–Polyurethane Foam Composite with Multilayered Structure

PubMed Central

Jiang, Xueliang; Yang, Zhen; Wang, Zhijie; Zhang, Fuqing; You, Feng

2018-01-01

Barium titanate/nitrile butadiene rubber (BT/NBR) and polyurethane (PU) foam were combined to prepare a sound-absorbing material with an alternating multilayered structure. The effects of the cell size of PU foam and the alternating unit number on the sound absorption property of the material were investigated. The results show that the sound absorption efficiency at a low frequency increased when decreasing the cell size of PU foam layer. With the increasing of the alternating unit number, the material shows the sound absorption effect in a wider bandwidth of frequency. The BT/NBR-PU foam composites with alternating multilayered structure have an excellent sound absorption property at low frequency due to the organic combination of airflow resistivity, resonance absorption, and interface dissipation. PMID:29565321

Preparation and Sound Absorption Properties of a Barium Titanate/Nitrile Butadiene Rubber-Polyurethane Foam Composite with Multilayered Structure.

PubMed

Jiang, Xueliang; Yang, Zhen; Wang, Zhijie; Zhang, Fuqing; You, Feng; Yao, Chu

2018-03-22

Barium titanate/nitrile butadiene rubber (BT/NBR) and polyurethane (PU) foam were combined to prepare a sound-absorbing material with an alternating multilayered structure. The effects of the cell size of PU foam and the alternating unit number on the sound absorption property of the material were investigated. The results show that the sound absorption efficiency at a low frequency increased when decreasing the cell size of PU foam layer. With the increasing of the alternating unit number, the material shows the sound absorption effect in a wider bandwidth of frequency. The BT/NBR-PU foam composites with alternating multilayered structure have an excellent sound absorption property at low frequency due to the organic combination of airflow resistivity, resonance absorption, and interface dissipation.

Wind Energy Program Summary. Volume 2: Research summaries, fiscal year 1988

NASA Astrophysics Data System (ADS)

1989-04-01

Activities by the Federal Wind Energy program since the early 1980s have focused on developing a technology base necessary for industry to demonstrate the viability of wind energy as an alternative energy supply. The Federal Wind Energy Program's research has targeted the sciences of wind turbine dynamics and the development of advanced components and systems. These efforts have resulted in major advancements toward the development and commercialization of wind technology as an alternative energy source. The installation of more than 16,000 wind turbines in California by the end of 1987 provides evidence that commercial use of wind energy technology can be a viable source of electric power. Research in wind turbine sciences has focused on atmospheric fluid dynamics, aerodynamics, and structural dynamics. As outlines in the projects that are described in this document, advancements in atmospheric fluid dynamics have been made through the development and refinement of wind characterization models and wind/rotor interaction prediction codes. Recent gains in aerodynamics can be attributed to a better understanding of airfoil operations, using innovative research approaches such as flow-visualization techniques. Qualitative information and data from laboratory and field tests are being used to document fatigue damage processes. These data are being used to develop new theories and data bases for structural dynamics, and will help to achieve long-term unit life and lower capital and maintenance costs. Material characterization and modeling techniques have been improved to better analyze effects of stress and fatigue on system components.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

DOE PAGES

Fenalti, Gustavo; Zatsepin, Nadia A.; Betti, Cecilia; ...

2015-02-16

Bi-functional μ- and δ- opioid receptor (OR) ligands are potential therapeutic alternatives to alkaloid opiate analgesics with diminished side effects. We solved the structure of human δ-OR bound to the bi-functional δ-OR antagonist and μ-OR agonist tetrapeptide H-Dmt-Tic-Phe-Phe-NH 2 (DIPP-NH 2) by serial femtosecond crystallography, revealing a cis-peptide bond between H-Dmt and Tic. In summary, the observed receptor-peptide interactions are critical to understand the pharmacological profiles of opioid peptides, and to develop improved analgesics.

YAdumper: extracting and translating large information volumes from relational databases to structured flat files.

PubMed

Fernández, José M; Valencia, Alfonso

2004-10-12

Downloading the information stored in relational databases into XML and other flat formats is a common task in bioinformatics. This periodical dumping of information requires considerable CPU time, disk and memory resources. YAdumper has been developed as a purpose-specific tool to deal with the integral structured information download of relational databases. YAdumper is a Java application that organizes database extraction following an XML template based on an external Document Type Declaration. Compared with other non-native alternatives, YAdumper substantially reduces memory requirements and considerably improves writing performance.

A Queue Simulation Tool for a High Performance Scientific Computing Center

NASA Technical Reports Server (NTRS)

Spear, Carrie; McGalliard, James

2007-01-01

The NASA Center for Computational Sciences (NCCS) at the Goddard Space Flight Center provides high performance highly parallel processors, mass storage, and supporting infrastructure to a community of computational Earth and space scientists. Long running (days) and highly parallel (hundreds of CPUs) jobs are common in the workload. NCCS management structures batch queues and allocates resources to optimize system use and prioritize workloads. NCCS technical staff use a locally developed discrete event simulation tool to model the impacts of evolving workloads, potential system upgrades, alternative queue structures and resource allocation policies.

Space construction base control system

NASA Technical Reports Server (NTRS)

Kaczynski, R. F.

1979-01-01

Several approaches for an attitude control system are studied and developed for a large space construction base that is structurally flexible. Digital simulations were obtained using the following techniques: (1) the multivariable Nyquist array method combined with closed loop pole allocation, (2) the linear quadratic regulator method. Equations for the three-axis simulation using the multilevel control method were generated and are presented. Several alternate control approaches are also described. A technique is demonstrated for obtaining the dynamic structural properties of a vehicle which is constructed of two or more submodules of known dynamic characteristics.

Directly polished lightweight aluminum mirror

NASA Astrophysics Data System (ADS)

ter Horst, Rik; Tromp, Niels; de Haan, Menno; Navarro, Ramon; Venema, Lars; Pragt, Johan

2017-11-01

During the last ten years, Astron has been a major contractor for the design and manufacturing of astronomical instruments for Space- and Earth based observatories, such as VISIR, MIDI, SPIFFI, X-Shooter and MIRI. Driven by the need to reduce the weight of optically ultra-stiff structures, two promising techniques have been developed in the last years: ASTRON Extreme Lightweighting [1][2] for mechanical structures and an improved Polishing Technique for Aluminum Mirrors. Using one single material for both optical components and mechanical structure simplifies the design of a cryogenic instrument significantly, it is very beneficial during instrument test and verification, and makes the instrument insensitive to temperature changes. Aluminum has been the main material used for cryogenic optical instruments, and optical aluminum mirrors are generally diamond turned. The application of a polishable hard top coating like nickel removes excess stray light caused by the groove pattern, but limits the degree of lightweighting of the mirrors due to the bi-metal effect. By directly polishing the aluminum mirror surface, the recent developments at Astron allow for using a non-exotic material for light weighted yet accurate optical mirrors, with a lower surface roughness ( 1nm RMS), higher surface accuracy and reduced light scattering. This paper presents the techniques, obtained results and a global comparison with alternative lightweight mirror solutions. Recent discussions indicate possible extensions of the extreme light weight technology to alternative materials such as Zerodur or Silicon Carbide.

Scanning Probe Microscopy for Identifying the Component Materials of a Nanostripe Structure

NASA Astrophysics Data System (ADS)

Mizuno, Akira; Ando, Yasuhisa

2010-08-01

The authors prepared a nanostripe structure in which two types of metal are arranged alternately, and successfully identified the component materials using scanning probe microscopy (SPM) to measure the lateral force distribution image. The nanostripe structure was prepared using a new method developed by the authors and joint development members. The lateral force distribution image was measured in both friction force microscopy (FFM) and lateral modulation friction force microscopy (LM-FFM) modes. In FFM mode, the effect of slope angle appeared in the lateral force distribution image; therefore, no difference in the type of material was observed. On the other hand, in LM-FFM mode, the effect of surface curvature was observed in the lateral force distribution image. A higher friction force on chromium than on gold was identified, enabling material identification.

Structure and location of macronutrients in ancient and alternative crops (abstract)

USDA-ARS?s Scientific Manuscript database

Structure, histochemistry and composition of mature seeds of several ancient or alternative crops were studied by light and electron microscopies to localize specific macronutrients including protein, starch, non-starch carbohydrates and lipid. Botanically, these seeds fall into different classifica...

Balancing alternative land uses in conservation prioritization.

PubMed

Moilanen, Atte; Anderson, Barbara J; Eigenbrod, Felix; Heinemeyer, Andreas; Roy, David B; Gillings, Simon; Armsworth, Paul R; Gaston, Kevin J; Thomas, Chris D

2011-07-01

Pressure on ecosystems to provide various different and often conflicting services is immense and likely to increase. The impacts and success of conservation prioritization will be enhanced if the needs of competing land uses are recognized at the planning stage. We develop such methods and illustrate them with data about competing land uses in Great Britain, with the aim of developing a conservation priority ranking that balances between needs of biodiversity conservation, carbon storage, agricultural value, and urban development potential. While both carbon stocks and biodiversity are desirable features from the point of view of conservation, they compete with the needs of agriculture and urban development. In Britain the greatest conflicts exist between biodiversity and urban areas, while the largest carbon stocks occur mostly in Scotland in areas with low agricultural or urban pressure. In our application, we were able successfully to balance the spatial allocation of alternative land uses so that conflicts between them were much smaller than had they been developed separately. The proposed methods and software, Zonation, are applicable to structurally similar prioritization problems globally.

Animal use replacement, reduction, and refinement: development of an integrated testing strategy for bioconcentration of chemicals in fish.

PubMed

de Wolf, Watze; Comber, Mike; Douben, Peter; Gimeno, Sylvia; Holt, Martin; Léonard, Marc; Lillicrap, Adam; Sijm, Dick; van Egmond, Roger; Weisbrod, Anne; Whale, Graham

2007-01-01

When addressing the use of fish for the environmental safety of chemicals and effluents, there are many opportunities for applying the principles of the 3Rs: Reduce, Refine, and Replace. The current environmental regulatory testing strategy for bioconcentration and secondary poisoning has been reviewed, and alternative approaches that provide useful information are described. Several approaches can be used to reduce the number of fish used in the Organization for Economic Cooperation and Development (OECD) Test Guideline 305, including alternative in vivo test methods such as the dietary accumulation test and the static exposure approach. The best replacement approach would seem to use read-across, chemical grouping, and quantitative structure-activity relationships with an assessment of the key processes in bioconcentration: Adsorption, distribution, metabolism, and excretion. Biomimetic extraction has particular usefulness in addressing bioavailable chemicals and is in some circumstances capable of predicting uptake. Use of alternative organisms such as invertebrates should also be considered. A single cut-off value for molecular weight and size beyond which no absorption will take place cannot be identified. Recommendations for their use in bioaccumulative (B) categorization schemes are provided. Assessment of biotransformation with in vitro assays and in silico approaches holds significant promise. Further research is needed to identify their variability and confidence limits and the ways to use this as a basis to estimate bioconcentration factors. A tiered bioconcentration testing strategy has been developed taking account of the alternatives discussed.

Northwest Montana/North Idaho transmission corridor study: a computer-assisted corridor location and impact evaluation assessment

Treesearch

Timothy J. Murray; Daniel J. Bisenius; Jay G. Marcotte

1979-01-01

A computer-assisted method was used to locate and evaluate approximately 1,200 miles of alternative corridors within an 8,000 square mile study region. The method involved in-depth impact analyses for nine major location criteria or determinant models. Regional "experts" from the Rocky Mountain area participated with BPA in developing model structure....

Growth and yield considerations and implications for alternative density management objectives and approaches

Treesearch

David Marshall

2013-01-01

Density management through thinning is the most important tool foresters have to aff ect stand development and stand structure of existing stands. Reducing stand density by thinning increases the growing space and resource availability (e.g., light, water, and nutrients) for the remaining trees. Th is can result in increased average tree growth. More available site...

The forest and agricultural sector optimization model (FASOM): model structure and policy applications.

Treesearch

Darius M. Adams; Ralph J. Alig; J.M. Callaway; Bruce A. McCarl; Steven M. Winnett

1996-01-01

The Forest and Agricultural Sector Optimization Model (FASOM) is a dynamic, nonlinear programming model of the forest and agricultural sectors in the United States. The FASOM model initially was developed to evaluate welfare and market impacts of alternative policies for sequestering carbon in trees but also has been applied to a wider range of forest and agricultural...

Analysis of Narratives Produced by Four Children Who Use Augmentative and Alternative Communication

ERIC Educational Resources Information Center

Soto, Gloria; Hartmann, Elizabeth

2006-01-01

The ability to narrate a story is fundamental to the development of overall communicative competence and involves the coordination of a variety of knowledge structures and linguistic abilities. In this study, the narrative discourse abilities of four children who use AAC are described in the context of five tasks designed to elicit a spectrum of…

Transcriptional control by G-quadruplexes: In vivo roles and perspectives for specific intervention

PubMed Central

Armas, Pablo; David, Aldana; Calcaterra, Nora B.

2017-01-01

ABSTRACT G-quadruplexes are non-canonical DNA secondary structures involved in several genomic and molecular processes. Here, we summarize the main G-quadruplex features and evidences proving the in vivo role on the transcriptional regulation of genes required for zebrafish embryonic development. We also discuss alternative strategies for specifically interfering G-quadruplex in vivo. PMID:27696937

Development of an Ecoliteracy Scale Intended for Adults and Testing an Alternative Model by Structural Equation Modelling

ERIC Educational Resources Information Center

Okur-Berberoglu, Emel

2018-01-01

Ecoliteracy is to understand and internalise sustainable ecological relationship in the nature and to transfer this sustainable lifestyle to daily life despite the fact that ecoliteracy does not have only one and unique definition. However, it is difficult to measure ecoliteracy due to it being a complex concept. There are many subsets of…

Alternate Models of Sibling Status Effects on Health in Later Life

ERIC Educational Resources Information Center

Falbo, Toni; Kim, Sunghun; Chen, Kuan-yi

2009-01-01

Although siblings are thought to be influential in child development, little is known about the influence of sibling status on the health of older adults. Using structural equation modeling, the authors created and tested a series of models with data from a sample (N = 3,968) of 1957 high school graduates from the Wisconsin Longitudinal Study. The…

Planning Alternative Organizational Frameworks For a Large Scale Educational Telecommunications System Served by Fixed/Broadcast Satellites. Memorandum Number 73/3.

ERIC Educational Resources Information Center

Walkmeyer, John

Considerations relating to the design of organizational structures for development and control of large scale educational telecommunications systems using satellites are explored. The first part of the document deals with four issues of system-wide concern. The first is user accessibility to the system, including proximity to entry points, ability…

The Economics and Politics of Structure: The Multidivisional Form and the Large U.S. Corporation.

ERIC Educational Resources Information Center

Palmer, Donald; And Others

1987-01-01

Develops and tests alternative political and ecological life-cycle explanations of the multidivisional form (MDF) now typical of large corporations. Unlike the functional or unitary form, MDF organizes tasks into units based on products or geographical markets. Banking firms are less diverse and less likely to use MDF. Includes 5 tables, 72…

Donor Motivations and Decision Making: Understanding the Major Gift Development Process from a Donor's Perspective

ERIC Educational Resources Information Center

Morrison, Anna Lee

2015-01-01

Higher education is faced with a challenge to its traditional funding structure. As a result, academic programs must seek alternative sources of support. Chief among these sources is philanthropy in the form of major gifts. Insight into donor motivations and decision making when approached to consider a major gift may help to maximize the success…

Rand Arroyo Center 2014

DTIC Science & Technology

2015-01-01

field effective command and control sys- tems within the framework of current policies and processes. Cost Considerations in Cloud Computing ...www.rand.org/t/PE113 Finds that cloud provider costs can vary compared with tradi- tional information system alternatives because of different cost structures...for analysts evaluating new cloud investments. U.S. Army photo by Staff Sgt. Christopher Calvert FOCUS ON Capabilities Development and Acquisition

Process Approach for Modeling of Machine and Tractor Fleet Structure

NASA Astrophysics Data System (ADS)

Dokin, B. D.; Aletdinova, A. A.; Kravchenko, M. S.; Tsybina, Y. S.

2018-05-01

The existing software complexes on modelling of the machine and tractor fleet structure are mostly aimed at solving the task of optimization. However, the creators, choosing only one optimization criterion and incorporating it in their software, provide grounds on why it is the best without giving a decision maker the opportunity to choose it for their enterprise. To analyze “bottlenecks” of machine and tractor fleet modelling, the authors of this article created a process model, in which they included adjustment to the plan of using machinery based on searching through alternative technologies. As a result, the following recommendations for software complex development have been worked out: the introduction of a database of alternative technologies; the possibility for a user to change the timing of the operations even beyond the allowable limits and in that case the calculation of the incurred loss; the possibility to rule out the solution of an optimization task, and if there is a necessity in it - the possibility to choose an optimization criterion; introducing graphical display of an annual complex of works, which could be enough for the development and adjustment of a business strategy.

Study of structural active cooling and heat sink systems for space shuttle

NASA Technical Reports Server (NTRS)

1972-01-01

This technology investigation was conducted to evaluate the feasibility of a number of thermal protection systems (TPS) concepts which are alternate candidates to the space shuttle baseline TPS. Four independent tasks were performed. Task 1 consisted of an in-depth evaluation of active structural cooling of the space shuttle orbiter. In Task 2, heat sink concepts for the booster were studied to identify and postulate solutions for design problems unique to heat sink TPS. Task 3 consisted of a feasibility demonstration test of a phase change material (PCM) incorporated into a reusable surface insulation (RSI) thermal protection system for the shuttle orbiter. In Task 4 the feasibility of heat pipes for stagnation region cooling was studied for the booster and the orbiter. Designs were developed for the orbiter leading edge and used in trade studies of leading edge concepts. At the time this program was initiated, a 2-stage fully reusable shuttle system was envisioned; therefore, the majority of the tasks were focused on the fully reusable system environments. Subsequently, a number of alternate shuttle system approaches, with potential for reduced shuttle system development funding requirements, were proposed. Where practicable, appropriate shifts in emphasis and task scoping were made to reflect these changes.

The auxetic behavior of an expanded periodic cellular structure

NASA Astrophysics Data System (ADS)

Ciolan, Mihaela A.; Lache, Simona; Velea, Marian N.

2018-02-01

Within nowadays research, when it comes to lightweight sandwich panels, periodic cellular structures are considered real trendsetters. One of the most used type of core in producing sandwich panels is the honeycomb. However, due to its relatively high manufacturing cost, this structure has limited applications; therefore, research has been carried out in order to develop alternative solutions. An example in this sense is the ExpaAsym cellular structure, developed at the Transilvania University of Braşov; it represents a periodic cellular structure manufactured through a mechanically expansion process of a previously cut and perforated sheet material. The relative density of the structure was proven to be significantly lower than the one of the honeycomb. This gives a great advantage to the structure, due to the fact that when the internal angle A of the unit cell is 60°, after the mechanical expansion it results a hexagonal structure. The main objective of this paper is to estimate the in-plane Poisson ratios of the structure, in terms of its geometrical parameters. It is therefore analytically shown that for certain values of the geometric parameters, the in-plane Poisson ratios have negative values when the internal angle exceeds 90°, which determines its auxetic behavior.

Design structure for in-system redundant array repair in integrated circuits

DOEpatents

Bright, Arthur A.; Crumley, Paul G.; Dombrowa, Marc; Douskey, Steven M.; Haring, Rudolf A.; Oakland, Steven F.; Quellette, Michael R.; Strissel, Scott A.

2008-11-25

A design structure for repairing an integrated circuit during operation of the integrated circuit. The integrated circuit comprising of a multitude of memory arrays and a fuse box holding control data for controlling redundancy logic of the arrays. The design structure provides the integrated circuit with a control data selector for passing the control data from the fuse box to the memory arrays; providing a source of alternate control data, external of the integrated circuit; and connecting the source of alternate control data to the control data selector. The design structure further passes the alternate control data from the source thereof, through the control data selector and to the memory arrays to control the redundancy logic of the memory arrays.

Work unit compensation.

PubMed

Sodano, M J

1991-01-01

The author describes an innovative "work unit compensation" system that acts as an adjunct to existing personnel payment structures. The process, developed as a win-win alternative for both employees and their institution, includes a reward system for the entire department and insures a team atmosphere. The Community Medical Center in Toms River, New Jersey developed the plan which sets the four basic goals: to be fair, economical, lasting and transferable (FELT). The plan has proven to be a useful tool in retention and recruitment of qualified personnel.

Solar power satellite system definition study. Part 2, volume 4: Microwave power transmission systems

NASA Technical Reports Server (NTRS)

1977-01-01

A slotted waveguide planar array was established as the baseline design for the spaceborne transmitter antenna. Key aspects of efficient energy conversion at both ends of the power transfer link were analyzed and optimized alternate approaches in the areas of antenna and tube design are discussed. An integrated design concept was developed which meets design requirements, observes structural and thermal constraints, exhibits good performance and was developed in adequate depth to permit cost estimating at the subsystem/component level.

Evaluation Of Back Shape Using The ISIS Scanner

NASA Astrophysics Data System (ADS)

Turner-Smith, Alan R.; Thomas, David C.

1989-04-01

The Integrated Shape Investigation System (ISIS) is a structured light scanner and shape analysis system, developed as a safe alternative to follow-up radiographs for the clinical assessment of deformities of the human back. The system is described and results presented of several clinic studies. These show a significant correlation between ISIS measures and conventional radiographic measures of spinal curvature, such as the Cobb angle. The development of a predictor for deterioration in adolescent idiopathic scoliosis, based on surface shape weasures, is discussed.

Impacts of Annealing Conditions on the Flat Band Voltage of Alternate La2O3/Al2O3 Multilayer Stack Structures.

PubMed

Feng, Xing-Yao; Liu, Hong-Xia; Wang, Xing; Zhao, Lu; Fei, Chen-Xi; Liu, He-Lei

2016-12-01

The mechanism of flat band voltage (VFB) shift for alternate La2O3/Al2O3 multilayer stack structures in different annealing condition is investigated. The samples were prepared for alternate multilayer structures, which were annealed in different conditions. The capacitance-voltage (C-V) measuring results indicate that the VFB of samples shift negatively for thinner bottom Al2O3 layer, increasing annealing temperature or longer annealing duration. Simultaneously, the diffusion of high-k material to interfaces in different multilayer structures and annealing conditions is observed by X-ray photoelectron spectroscopy (XPS). Based on the dipole theory, a correlation between the diffusion effect of La towards bottom Al2O3/Si interface and VFB shift is found. Without changing the dielectric constant k of films, VFB shift can be manipulated by controlling the single-layer cycles and annealing conditions of alternate high-k multilayer stack.

Network evolution induced by asynchronous stimuli through spike-timing-dependent plasticity.

PubMed

Yuan, Wu-Jie; Zhou, Jian-Fang; Zhou, Changsong

2013-01-01

In sensory neural system, external asynchronous stimuli play an important role in perceptual learning, associative memory and map development. However, the organization of structure and dynamics of neural networks induced by external asynchronous stimuli are not well understood. Spike-timing-dependent plasticity (STDP) is a typical synaptic plasticity that has been extensively found in the sensory systems and that has received much theoretical attention. This synaptic plasticity is highly sensitive to correlations between pre- and postsynaptic firings. Thus, STDP is expected to play an important role in response to external asynchronous stimuli, which can induce segregative pre- and postsynaptic firings. In this paper, we study the impact of external asynchronous stimuli on the organization of structure and dynamics of neural networks through STDP. We construct a two-dimensional spatial neural network model with local connectivity and sparseness, and use external currents to stimulate alternately on different spatial layers. The adopted external currents imposed alternately on spatial layers can be here regarded as external asynchronous stimuli. Through extensive numerical simulations, we focus on the effects of stimulus number and inter-stimulus timing on synaptic connecting weights and the property of propagation dynamics in the resulting network structure. Interestingly, the resulting feedforward structure induced by stimulus-dependent asynchronous firings and its propagation dynamics reflect both the underlying property of STDP. The results imply a possible important role of STDP in generating feedforward structure and collective propagation activity required for experience-dependent map plasticity in developing in vivo sensory pathways and cortices. The relevance of the results to cue-triggered recall of learned temporal sequences, an important cognitive function, is briefly discussed as well. Furthermore, this finding suggests a potential application for examining STDP by measuring neural population activity in a cultured neural network.

Model averaging in the presence of structural uncertainty about treatment effects: influence on treatment decision and expected value of information.

PubMed

Price, Malcolm J; Welton, Nicky J; Briggs, Andrew H; Ades, A E

2011-01-01

Standard approaches to estimation of Markov models with data from randomized controlled trials tend either to make a judgment about which transition(s) treatments act on, or they assume that treatment has a separate effect on every transition. An alternative is to fit a series of models that assume that treatment acts on specific transitions. Investigators can then choose among alternative models using goodness-of-fit statistics. However, structural uncertainty about any chosen parameterization will remain and this may have implications for the resulting decision and the need for further research. We describe a Bayesian approach to model estimation, and model selection. Structural uncertainty about which parameterization to use is accounted for using model averaging and we developed a formula for calculating the expected value of perfect information (EVPI) in averaged models. Marginal posterior distributions are generated for each of the cost-effectiveness parameters using Markov Chain Monte Carlo simulation in WinBUGS, or Monte-Carlo simulation in Excel (Microsoft Corp., Redmond, WA). We illustrate the approach with an example of treatments for asthma using aggregate-level data from a connected network of four treatments compared in three pair-wise randomized controlled trials. The standard errors of incremental net benefit using structured models is reduced by up to eight- or ninefold compared to the unstructured models, and the expected loss attaching to decision uncertainty by factors of several hundreds. Model averaging had considerable influence on the EVPI. Alternative structural assumptions can alter the treatment decision and have an overwhelming effect on model uncertainty and expected value of information. Structural uncertainty can be accounted for by model averaging, and the EVPI can be calculated for averaged models. Copyright © 2011 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Comparison of two matrix data structures for advanced CSM testbed applications

NASA Technical Reports Server (NTRS)

Regelbrugge, M. E.; Brogan, F. A.; Nour-Omid, B.; Rankin, C. C.; Wright, M. A.

1989-01-01

The first section describes data storage schemes presently used by the Computational Structural Mechanics (CSM) testbed sparse matrix facilities and similar skyline (profile) matrix facilities. The second section contains a discussion of certain features required for the implementation of particular advanced CSM algorithms, and how these features might be incorporated into the data storage schemes described previously. The third section presents recommendations, based on the discussions of the prior sections, for directing future CSM testbed development to provide necessary matrix facilities for advanced algorithm implementation and use. The objective is to lend insight into the matrix structures discussed and to help explain the process of evaluating alternative matrix data structures and utilities for subsequent use in the CSM testbed.

Lifetime costing of the body-in-white: Steel vs. aluminum

NASA Astrophysics Data System (ADS)

Han, Helen N.; Clark, Joel P.

1995-05-01

In order to make informed material choice decisions and to derive the maximum benefit from the use of alternative materials, the automobile producer must understand the full range of costs and benefits for each material. It is becoming clear that the conventional cost-benefit analysis structure currently used by the automotive industry must be broadened to include nontraditional costs such as the environmental externalities associated with the use of existing and potential automotive technologies. This article develops a methodology for comparing the costs and benefits associated with the use of alternative materials in automotive applications by focusing on steel and aluminum in the unibody body-in-white. Authors' Note: This is the first of two articles documenting a methodology for evaluating the lifetime monetary and environmental costs of alternative materials in automotive applications. This article addresses the traditional money costs while a subsequent paper, which is planned for the August issue, will address the environmental externalities.

Expert reasoning within an object-oriented framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bohn, S.J.; Pennock, K.A.

1991-10-01

A large number of contaminated waste sites across the United States await site remediation efforts. These sites can be physically complex, composed of multiple, possibly interacting, contaminants distributed throughout one or more media. The Remedial Action Assessment System (RAAS) is being designed and developed to support decisions concerning the selection of remediation alternatives. The goal of this system is to broaden the consideration of remediation alternatives, while reducing the time and cost of making these considerations. The Remedial Action Assessment System was designed and constructed using object-oriented techniques. It is a hybrid system which uses a combination of quantitative andmore » qualitative reasoning to consider and suggest remediation alternatives. the reasoning process that drives this application is centered around an object-oriented organization of remediation technology information. This paper briefly describes the waste remediation problem and then discusses the information structure and organization RAAS utilizes to address it. 4 refs., 4 figs.« less

Hierarchical segmentation of the Malawi Rift: The influence of inherited lithospheric heterogeneity and kinematics in the evolution of continental rifts

NASA Astrophysics Data System (ADS)

Laó-Dávila, Daniel A.; Al-Salmi, Haifa S.; Abdelsalam, Mohamed G.; Atekwana, Estella A.

2015-12-01

We used detailed analysis of Shuttle Radar Topography Mission-digital elevation model and observations from aeromagnetic data to examine the influence of inherited lithospheric heterogeneity and kinematics in the segmentation of largely amagmatic continental rifts. We focused on the Cenozoic Malawi Rift, which represents the southern extension of the Western Branch of the East African Rift System. This north trending rift traverses Precambrian and Paleozoic-Mesozoic structures of different orientations. We found that the rift can be hierarchically divided into first-order and second-order segments. In the first-order segmentation, we divided the rift into Northern, Central, and Southern sections. In its Northern Section, the rift follows Paleoproterozoic and Neoproterozoic terrains with structural grain that favored the localization of extension within well-developed border faults. The Central Section occurs within Mesoproterozoic-Neoproterozoic terrain with regional structures oblique to the rift extent. We propose that the lack of inherited lithospheric heterogeneity favoring extension localization resulted in the development of the rift in this section as a shallow graben with undeveloped border faults. In the Southern Section, Mesoproterozoic-Neoproterozoic rocks were reactivated and developed the border faults. In the second-order segmentation, only observed in the Northern Section, we divided the section into five segments that approximate four half-grabens/asymmetrical grabens with alternating polarities. The change of polarity coincides with flip-over full-grabens occurring within overlap zones associated with ~150 km long alternating border faults segments. The inherited lithospheric heterogeneity played the major role in facilitating the segmentation of the Malawi Rift during its opening resulting from extension.

Marginalized Student Access to Technology Education

NASA Astrophysics Data System (ADS)

Kurtcu, Wanda M.

The purpose of this paper is to investigate how a teacher can disrupt an established curriculum that continues the cycle of inequity of access to science, technology, engineering, and math (STEM) curriculum by students in alternative education. For this paper, I will focus on the technology components of the STEM curriculum. Technology in the United States, if not the world economy, is developing at a rapid pace. Many areas of day to day living, from applying for a job to checking one's bank account online, involve a component of science and technology. The 'gap' in technology education is emphasized between the 'haves and have-nots', which is delineated along socio-economic lines. Marginalized students in alternative education programs use this equipment for little else than remedial programs and credit recovery. This level of inequity further widens in alternative education programs and affects the achievement of marginalized students in credit recovery or alternative education classes instead of participation technology classes. For the purposes of this paper I focus on how can I decrease the inequity of student access to 21st century technology education in an alternative education program by addressing the established curriculum of the program and modifying structural barriers of marginalized student access to a technology focused curriculum.

Apparatus for efficient sidewall containment of molten metal with horizontal alternating magnetic fields utilizing a ferromagnetic dam

DOEpatents

Praeg, Walter F.

1997-01-01

An apparatus for casting sheets of metal from molten metal. The apparatus includes a containment structure having an open side, a horizontal alternating magnetic field generating structure and a ferromagnetic dam. The magnetic field and the ferromagnetic dam contain the molten metal from leaking out side portions of the open side of the containment structure.

Variable stiffness mechanisms with SMA actuators

NASA Astrophysics Data System (ADS)

Siler, Damin J.; Demoret, Kimberly B. J.

1996-05-01

Variable stiffness is a new branch of smart structures development with several applications related to aircraft. Previous research indicates that temporarily reducing the stiffness of an airplane wing can decrease control actuator sizing and improve aeroelastic roll performance. Some smart materials like shape memory alloys (SMA) can change their material stiffness properties, but they tend to gain stiffness in their `power on' state. An alternative is to integrate mechanisms into a structure and change stiffness by altering boundary conditions and structural load paths. An innovative concept for an axial strut mechanism was discovered as part of research into variable stiffness. It employs SMA springs (specifically Ni-Ti) in a way that reduces overall stiffness when the SMA springs gain stiffness. A simplified mathematical model for static analysis was developed, and a 70% reduction in stiffness was obtained for a particular selection of springs. The small force capacity of commercially available SMA springs limits the practicality of this concept for large load applications. However, smart material technology is still immature, and future advances may permit development of a heavy-duty, variable stiffness strut that is small and light enough for use in aircraft structures.

The logic of the floral transition: Reverse-engineering the switch controlling the identity of lateral organs.

PubMed

Dinh, Jean-Louis; Farcot, Etienne; Hodgman, Charlie

2017-09-01

Much laboratory work has been carried out to determine the gene regulatory network (GRN) that results in plant cells becoming flowers instead of leaves. However, this also involves the spatial distribution of different cell types, and poses the question of whether alternative networks could produce the same set of observed results. This issue has been addressed here through a survey of the published intercellular distribution of expressed regulatory genes and techniques both developed and applied to Boolean network models. This has uncovered a large number of models which are compatible with the currently available data. An exhaustive exploration had some success but proved to be unfeasible due to the massive number of alternative models, so genetic programming algorithms have also been employed. This approach allows exploration on the basis of both data-fitting criteria and parsimony of the regulatory processes, ruling out biologically unrealistic mechanisms. One of the conclusions is that, despite the multiplicity of acceptable models, an overall structure dominates, with differences mostly in alternative fine-grained regulatory interactions. The overall structure confirms the known interactions, including some that were not present in the training set, showing that current data are sufficient to determine the overall structure of the GRN. The model stresses the importance of relative spatial location, through explicit references to this aspect. This approach also provides a quantitative indication of how likely some regulatory interactions might be, and can be applied to the study of other developmental transitions.

How Do Households Respond to Unreliable Water Supplies? A Systematic Review.

PubMed

Majuru, Batsirai; Suhrcke, Marc; Hunter, Paul R

2016-12-09

Although the Millennium Development Goal (MDG) target for drinking water was met, in many developing countries water supplies are unreliable. This paper reviews how households in developing countries cope with unreliable water supplies, including coping costs, the distribution of coping costs across socio-economic groups, and effectiveness of coping strategies in meeting household water needs. Structured searches were conducted in peer-reviewed and grey literature in electronic databases and search engines, and 28 studies were selected for review, out of 1643 potentially relevant references. Studies were included if they reported on strategies to cope with unreliable household water supplies and were based on empirical research in developing countries. Common coping strategies include drilling wells, storing water, and collecting water from alternative sources. The choice of coping strategies is influenced by income, level of education, land tenure and extent of unreliability. The findings of this review highlight that low-income households bear a disproportionate coping burden, as they often engage in coping strategies such as collecting water from alternative sources, which is labour and time-intensive, and yields smaller quantities of water. Such alternative sources may be of lower water quality, and pose health risks. In the absence of dramatic improvements in the reliability of water supplies, a point of critical avenue of enquiry should be what coping strategies are effective and can be readily adopted by low income households.

How Do Households Respond to Unreliable Water Supplies? A Systematic Review

PubMed Central

Majuru, Batsirai; Suhrcke, Marc; Hunter, Paul R.

2016-01-01

Although the Millennium Development Goal (MDG) target for drinking water was met, in many developing countries water supplies are unreliable. This paper reviews how households in developing countries cope with unreliable water supplies, including coping costs, the distribution of coping costs across socio-economic groups, and effectiveness of coping strategies in meeting household water needs. Structured searches were conducted in peer-reviewed and grey literature in electronic databases and search engines, and 28 studies were selected for review, out of 1643 potentially relevant references. Studies were included if they reported on strategies to cope with unreliable household water supplies and were based on empirical research in developing countries. Common coping strategies include drilling wells, storing water, and collecting water from alternative sources. The choice of coping strategies is influenced by income, level of education, land tenure and extent of unreliability. The findings of this review highlight that low-income households bear a disproportionate coping burden, as they often engage in coping strategies such as collecting water from alternative sources, which is labour and time-intensive, and yields smaller quantities of water. Such alternative sources may be of lower water quality, and pose health risks. In the absence of dramatic improvements in the reliability of water supplies, a point of critical avenue of enquiry should be what coping strategies are effective and can be readily adopted by low income households. PMID:27941695

Functionality of alternative protein in gluten-free product development.

PubMed

Deora, Navneet Singh; Deswal, Aastha; Mishra, Hari Niwas

2015-07-01

Celiac disease is an immune-mediated disease triggered in genetically susceptible individuals by ingested gluten from wheat, rye, barley, and other closely related cereal grains. The current treatment for celiac disease is life-long adherence to a strict gluten-exclusion diet. The replacement of gluten presents a significant technological challenge, as it is an essential structure-building protein, which is necessary for formulating high-quality baked goods. A major limitation in the production of gluten-free products is the lack of protein functionality in non-wheat cereals. Additionally, commercial gluten-free mixes usually contain only carbohydrates, which may significantly limit the amount of protein in the diet. In the recent past, various approaches are attempted to incorporate protein-based ingredients and to modify the functional properties for gluten-free product development. This review aims to the highlight functionality of the alternative protein-based ingredients, which can be utilized for gluten-free product development both functionally as well as nutritionally. © The Author(s) 2014.

A worthy self is a caring self: Examining the developmental relations between self-esteem and self-compassion in adolescents.

PubMed

Donald, James N; Ciarrochi, Joseph; Parker, Philip D; Sahdra, Baljinder K; Marshall, Sarah L; Guo, Jiesi

2017-08-18

Self-compassion has been framed as a healthy alternative to self-esteem, as it is nonevaluative. However, rather than being alternatives, it may be that the two constructs develop in a mutually reinforcing way. The present study tested this possibility among adolescents. A large adolescent sample (N = 2,809; 49.8% female) reported levels of trait self-esteem and self-compassion annually for 4 years. Autoregressive cross-lagged structural equation models were used to estimate the reciprocal longitudinal relations between the two constructs. Self-esteem consistently predicted changes in self-compassion across the 4 years of the study, but not vice versa. Self-esteem appears to be an important antecedent of the development of self-compassion, perhaps because the capacity to extend compassion toward the self depends on one's appraisals of worthiness. These findings add important insights to our theoretical understanding of the development of self-compassion. © 2017 Wiley Periodicals, Inc.

Advanced composite elevator for Boeing 727 aircraft, volume 2

NASA Technical Reports Server (NTRS)

Chovil, D. V.; Grant, W. D.; Jamison, E. S.; Syder, H.; Desper, O. E.; Harvey, S. T.; Mccarty, J. E.

1980-01-01

Preliminary design activity consisted of developing and analyzing alternate design concepts and selecting the optimum elevator configuration. This included trade studies in which durability, inspectability, producibility, repairability, and customer acceptance were evaluated. Preliminary development efforts consisted of evaluating and selecting material, identifying ancillary structural development test requirements, and defining full scale ground and flight test requirements necessary to obtain Federal Aviation Administration (FAA) certification. After selection of the optimum elevator configuration, detail design was begun and included basic configuration design improvements resulting from manufacturing verification hardware, the ancillary test program, weight analysis, and structural analysis. Detail and assembly tools were designed and fabricated to support a full-scope production program, rather than a limited run. The producibility development programs were used to verify tooling approaches, fabrication processes, and inspection methods for the production mode. Quality parts were readily fabricated and assembled with a minimum rejection rate, using prior inspection methods.

Physics and evolution of thermophilic adaptation.

PubMed

Berezovsky, Igor N; Shakhnovich, Eugene I

2005-09-06

Analysis of structures and sequences of several hyperthermostable proteins from various sources reveals two major physical mechanisms of their thermostabilization. The first mechanism is "structure-based," whereby some hyperthermostable proteins are significantly more compact than their mesophilic homologues, while no particular interaction type appears to cause stabilization; rather, a sheer number of interactions is responsible for thermostability. Other hyperthermostable proteins employ an alternative, "sequence-based" mechanism of their thermal stabilization. They do not show pronounced structural differences from mesophilic homologues. Rather, a small number of apparently strong interactions is responsible for high thermal stability of these proteins. High-throughput comparative analysis of structures and complete genomes of several hyperthermophilic archaea and bacteria revealed that organisms develop diverse strategies of thermophilic adaptation by using, to a varying degree, two fundamental physical mechanisms of thermostability. The choice of a particular strategy depends on the evolutionary history of an organism. Proteins from organisms that originated in an extreme environment, such as hyperthermophilic archaea (Pyrococcus furiosus), are significantly more compact and more hydrophobic than their mesophilic counterparts. Alternatively, organisms that evolved as mesophiles but later recolonized a hot environment (Thermotoga maritima) relied in their evolutionary strategy of thermophilic adaptation on "sequence-based" mechanism of thermostability. We propose an evolutionary explanation of these differences based on physical concepts of protein designability.

A technique for determining the deuterium/hydrogen contrast map in neutron macromolecular crystallography.

PubMed

Chatake, Toshiyuki; Fujiwara, Satoru

2016-01-01

A difference in the neutron scattering length between hydrogen and deuterium leads to a high density contrast in neutron Fourier maps. In this study, a technique for determining the deuterium/hydrogen (D/H) contrast map in neutron macromolecular crystallography is developed and evaluated using ribonuclease A. The contrast map between the D2O-solvent and H2O-solvent crystals is calculated in real space, rather than in reciprocal space as performed in previous neutron D/H contrast crystallography. The present technique can thus utilize all of the amplitudes of the neutron structure factors for both D2O-solvent and H2O-solvent crystals. The neutron D/H contrast maps clearly demonstrate the powerful detectability of H/D exchange in proteins. In fact, alternative protonation states and alternative conformations of hydroxyl groups are observed at medium resolution (1.8 Å). Moreover, water molecules can be categorized into three types according to their tendency towards rotational disorder. These results directly indicate improvement in the neutron crystal structure analysis. This technique is suitable for incorporation into the standard structure-determination process used in neutron protein crystallography; consequently, more precise and efficient determination of the D-atom positions is possible using a combination of this D/H contrast technique and standard neutron structure-determination protocols.

Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement

PubMed Central

Esser, Lothar; Yu, Chang-An; Xia, Di

2016-01-01

The emergence of drug resistance has devastating economic and social consequences, a testimonial of which is the rise and fall of inhibitors against the respiratory component cytochrome bc1 complex, a time tested and highly effective target for disease control. Unfortunately, the mechanism of resistance is a multivariate problem, including primarily mutations in the gene of the cytochrome b subunit but also activation of alternative pathways of ubiquinol oxidation and pharmacokinetic effects. There is a considerable interest in designing new bc1 inhibitors with novel modes of binding and lower propensity to induce the development of resistance. The accumulation of crystallographic data of bc1 complexes with and without inhibitors bound provides the structural basis for rational drug design. In particular, the cytochrome b subunit offers two distinct active sites that can be targeted for inhibition - the quinol oxidation site and the quinone reduction site. This review brings together available structural information of inhibited bc1 by various quinol oxidation- and reduction-site inhibitors, the inhibitor binding modes, conformational changes upon inhibitor binding of side chains in the active site and large scale domain movements of the iron-sulfur protein subunit. Structural data analysis provides a clear understanding of where and why existing inhibitors fail and points towards promising alternatives. PMID:23688079

Impact Testing of a Stirling Converter's Linear Alternator

NASA Technical Reports Server (NTRS)

Suarez, Vicente J.; Goodnight, Thomas W.; Hughes, William O.; Samorezov, Sergey

2002-01-01

The U.S. Department of Energy (DOE), in conjunction with the NASA John H. Glenn Research Center and Stirling Technology Company, are currently developing a Stirling convertor for a Stirling Radioisotope Generator (SRG). NASA Headquarters and DOE have identified the SRG for potential use as an advanced spacecraft power system for future NASA deep-space and Mars surface missions. Low-level dynamic impact tests were conducted at NASA Glenn Research Center's Structural Dynamics Laboratory as part of the development of this technology. The purpose of this test was to identify dynamic structural characteristics of the Stirling Technology Demonstration Convertor (TDC). This paper addresses the test setup, procedure, and results of the impact testing conducted on the Stirling TDC in May 2001.

Impact testing of a Stirling convertor's linear alternator

NASA Astrophysics Data System (ADS)

Suárez, Vicente J.; Goodnight, Thomas W.; Hughes, William O.; Samorezov, Sergey

2002-01-01

The U.S. Department of Energy (DOE), in conjunction with NASA John H. Glenn Research Center and Stirling Technology Company, are currently developing a Stirling convertor for a Stirling Radioisotope Generator (SRG). NASA Headquarters and DOE have identified the SRG for potential use as an advanced spacecraft power system for future NASA deep-space and Mars surface missions. Low-level dynamic impact tests were conducted at NASA Glenn Research Center's Structural Dynamics Laboratory as part of the development of this technology. The purpose of this test was to identify dynamic structural characteristics of the Stirling Technology Demonstration Convertor (TDC). This paper addresses the test setup, procedure and results of the impact testing conducted on the Stirling TDC in May 2001. .

Do gender and directness of trauma exposure moderate PTSD's latent structure?

PubMed

Frankfurt, Sheila B; Armour, Cherie; Contractor, Ateka A; Elhai, Jon D

2016-11-30

The PTSD diagnosis and latent structure were substantially revised in the transition from DSM-IV to DSM-5. However, three alternative models (i.e., anhedonia model, externalizing behavior model, and hybrid model) of PTSD fit the DSM-5 symptom criteria better than the DSM-5 factor model. Thus, the psychometric performance of the DSM-5 and alternative models' PTSD factor structure needs to be critically evaluated. The current study examined whether gender or trauma directness (i.e., direct or indirect trauma exposure) moderates the PTSD latent structure when using the DSM-5 or alternative models. Model performance was evaluated with measurement invariance testing procedures on a large undergraduate sample (n=455). Gender and trauma directness moderated the DSM-5 PTSD and externalizing behavior model and did not moderate the anhedonia and hybrid models' latent structure. Clinical implications and directions for future research are discussed. Published by Elsevier Ireland Ltd.

46 CFR 116.340 - Alternate design considerations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety... does not meet the requirements of § 116.300, if it is shown by systematic analysis based on engineering principles that the vessel structure provides adequate safety and strength. An owner seeking approval of an...

46 CFR 116.340 - Alternate design considerations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety... does not meet the requirements of § 116.300, if it is shown by systematic analysis based on engineering principles that the vessel structure provides adequate safety and strength. An owner seeking approval of an...

46 CFR 116.340 - Alternate design considerations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety... does not meet the requirements of § 116.300, if it is shown by systematic analysis based on engineering principles that the vessel structure provides adequate safety and strength. An owner seeking approval of an...

46 CFR 176.600 - Drydock and internal structural examination intervals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... States port, it must undergo the required examination before sailing. (c) If your vessel is not operated... exclusively by divers, the vessel must undergo two alternate hull exams and two internal structural exams within any five-year period. If a vessel completes a satisfactory alternate hull exam, with the...

An Alternative to the Problematic Macro-Micro Structure of Introductory Economics.

ERIC Educational Resources Information Center

Tinari, Frank D.

The paper explains an alternative structure to teaching micro and macroeconomic theory and describes the characteristics that make it an effective framework for introductory and principles courses. The teaching of economics principles typically proceeds by separating macroeconomic theory and microeconomic theory. But the use of the macro-micro…

Evaluating WAIS-IV structure through a different psychometric lens: structural causal model discovery as an alternative to confirmatory factor analysis.

PubMed

van Dijk, Marjolein J A M; Claassen, Tom; Suwartono, Christiany; van der Veld, William M; van der Heijden, Paul T; Hendriks, Marc P H

Since the publication of the WAIS-IV in the U.S. in 2008, efforts have been made to explore the structural validity by applying factor analysis to various samples. This study aims to achieve a more fine-grained understanding of the structure of the Dutch language version of the WAIS-IV (WAIS-IV-NL) by applying an alternative analysis based on causal modeling in addition to confirmatory factor analysis (CFA). The Bayesian Constraint-based Causal Discovery (BCCD) algorithm learns underlying network structures directly from data and assesses more complex structures than is possible with factor analysis. WAIS-IV-NL profiles of two clinical samples of 202 patients (i.e. patients with temporal lobe epilepsy and a mixed psychiatric outpatient group) were analyzed and contrasted with a matched control group (N = 202) selected from the Dutch standardization sample of the WAIS-IV-NL to investigate internal structure by means of CFA and BCCD. With CFA, the four-factor structure as proposed by Wechsler demonstrates acceptable fit in all three subsamples. However, BCCD revealed three consistent clusters (verbal comprehension, visual processing, and processing speed) in all three subsamples. The combination of Arithmetic and Digit Span as a coherent working memory factor could not be verified, and Matrix Reasoning appeared to be isolated. With BCCD, some discrepancies from the proposed four-factor structure are exemplified. Furthermore, these results fit CHC theory of intelligence more clearly. Consistent clustering patterns indicate these results are robust. The structural causal discovery approach may be helpful in better interpreting existing tests, the development of new tests, and aid in diagnostic instruments.

Delayed-type hypersensitivity reactions induced by proton pump inhibitors: A clinical and in vitro T-cell reactivity study.

PubMed

Lin, C-Y; Wang, C-W; Hui, C-Y R; Chang, Y-C; Yang, C-H; Cheng, C-Y; Chen, W-W; Ke, W-M; Chung, W-H

2018-01-01

Proton pump inhibitors (PPIs) have been known to induce type I hypersensitivity reactions. However, severe delayed-type hypersensitivity reactions (DHR) induced by PPI, such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug rash with eosinophilia and systemic symptoms (DRESS), are rarely reported. We conducted a study of a large series of PPI-related DHR, followed up their tolerability to alternative anti-ulcer agents, and investigated the T-cell reactivity to PPI in PPI-related DHR patients. We retrospectively analyzed patients with PPI-related DHR from multiple medical centers in Taiwan during the study period January 2003 to April 2016. We analyzed the causative PPI, clinical manifestations, organ involvement, treatment, and complications. We also followed up the potential risk of cross-hypersensitivity or tolerability to other PPI after their hypersensitivity episodes. Drug lymphocyte activation test (LAT) was conducted by measuring granulysin and interferon-γ to confirm the causalities. There were 69 cases of PPI-related DHR, including SJS/TEN (n=27) and DRESS (n=10). The LAT by measuring granulysin showed a sensitivity of 59.3% and specificity of 96.4%. Esomeprazole was the most commonly involved in PPI-related DHR (51%). Thirteen patients allergic to one kind of PPI could tolerate other structurally different PPI without cross-hypersensitivity reactions, whereas three patients developed cross-hypersensitivity reactions to alternative structurally similar PPI. The cross-reactivity to structurally similar PPI was also observed in LAT assay. PPIs have the potential to induce life-threatening DHR. In patients when PPI is necessary for treatment, switching to structurally different alternatives should be considered. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Structured Analysis and Structured Design for the Logistic Support Analysis (LSA) Task 303 Evaluation of Alternatives and Trade-Off Analysis, LSA Subtask 303.2.2, Trade-Off Between Support System Alternatives and System/Equipment Alternatives

DTIC Science & Technology

1991-01-01

Field 3. Training and Training Devices: a. Factory training b. Instructor and key personnel training c. New equipment training plan d. New equipment...12345678901234567990123456789012345678901234567890123456789� 1. 0016 10 SUPPOR2AILITY ALTEIIIVE TRADE-OFF ANALISIS . 4. + 4" + 4. 4. 4 2. C1.0 111.0 N2.0 1.0 INITIATE

Methodological aspects of fuel performance system analysis at raw hydrocarbon processing plants

NASA Astrophysics Data System (ADS)

Kulbjakina, A. V.; Dolotovskij, I. V.

2018-01-01

The article discusses the methodological aspects of fuel performance system analysis at raw hydrocarbon (RH) processing plants. Modern RH processing facilities are the major consumers of energy resources (ER) for their own needs. To reduce ER, including fuel consumption, and to develop rational fuel system structure are complex and relevant scientific tasks that can only be done using system analysis and complex system synthesis. In accordance with the principles of system analysis, the hierarchical structure of the fuel system, the block scheme for the synthesis of the most efficient alternative of the fuel system using mathematical models and the set of performance criteria have been developed on the main stages of the study. The results from the introduction of specific engineering solutions to develop their own energy supply sources for RH processing facilities have been provided.

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers

PubMed Central

Lemmens, Bennie; van Schendel, Robin; Tijsterman, Marcel

2015-01-01

Faithful DNA replication is vital to prevent disease-causing mutations, chromosomal aberrations and malignant transformation. However, accuracy conflicts with pace and flexibility and cells rely on specialized polymerases and helicases to ensure effective and timely replication of genomes that contain DNA lesions or secondary structures. If and how cells can tolerate a permanent barrier to replication is, however, unknown. Here we show that a single unresolved G-quadruplexed DNA structure can persist through multiple mitotic divisions without changing conformation. Failed replication across a G-quadruplex causes single-strand DNA gaps that give rise to DNA double-strand breaks in subsequent cell divisions, which are processed by polymerase theta (POLQ)-mediated alternative end joining. Lineage tracing experiments further reveal that persistent G-quadruplexes cause genetic heterogeneity during organ development. Our data demonstrate that a single lesion can cause multiple unique genomic rearrangements, and that alternative end joining enables cells to proliferate in the presence of mitotically inherited replication blocks. PMID:26563448

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers.

PubMed

Lemmens, Bennie; van Schendel, Robin; Tijsterman, Marcel

2015-11-13

Faithful DNA replication is vital to prevent disease-causing mutations, chromosomal aberrations and malignant transformation. However, accuracy conflicts with pace and flexibility and cells rely on specialized polymerases and helicases to ensure effective and timely replication of genomes that contain DNA lesions or secondary structures. If and how cells can tolerate a permanent barrier to replication is, however, unknown. Here we show that a single unresolved G-quadruplexed DNA structure can persist through multiple mitotic divisions without changing conformation. Failed replication across a G-quadruplex causes single-strand DNA gaps that give rise to DNA double-strand breaks in subsequent cell divisions, which are processed by polymerase theta (POLQ)-mediated alternative end joining. Lineage tracing experiments further reveal that persistent G-quadruplexes cause genetic heterogeneity during organ development. Our data demonstrate that a single lesion can cause multiple unique genomic rearrangements, and that alternative end joining enables cells to proliferate in the presence of mitotically inherited replication blocks.

Recent advances in 193-nm single-layer photoresists based on alternating copolymers of cycloolefins

NASA Astrophysics Data System (ADS)

Houlihan, Francis M.; Wallow, Thomas I.; Timko, Allen G.; Neria, E.; Hutton, Richard S.; Cirelli, Raymond A.; Nalamasu, Omkaram; Reichmanis, Elsa

1997-07-01

We report on our recent investigations on the formulation and processing of 193 nm single layer photoresists based on alternating copolymers of cycloolefins with maleic anhydride. Resists formulated with cycloolefin copolymers are compatible with 0.262 N tetramethylammonium developers, have excellent adhesion, sensitivity, etch resistance and thermal flow properties. The effect of polymer structure and composition, dissolution inhibitor structure and loading as well as the effect of the photoacid generator on the resist dissolution properties was investigated. Based on the results high contrast formulations were evaluated on a GCA XLS (NA equals 0.53, 4X reduction optics) deep-UV stepper to exhibit 0.27 micrometer L/S pair resolution with excellent photosensitivity. Based on the dissolution properties and a spectroscopic examination of the resist, we have designed materials that show less than 0.17 micrometer L/S pair resolution with 193 nm exposures. In this paper, the formulation methodology is detailed and the most recent results upon both with 248 and 193 nm irradiation are described.

Effect of ultraviolet radiation in the photo-oxidation of High Density Polyethylene and Biodegradable Polyethylene films

NASA Astrophysics Data System (ADS)

Martínez-Romo, A.; González Mota, R.; Bernal, J. J. Soto; Frausto Reyes, C.; Rosales Candelas, I.

2015-01-01

One of the most widely used plastics in the world is the High density polyethylene (HDPE), it is a stable material due to its carbon-carbon bonds, causing their slow degradation; which is why we are looking for alternative ways to accelerate the degradation process of this polymer. An alternative is the addition of oxidized groups in its molecular structure, which results in the development of polymers susceptible to biodegradation (PE-BIO). In this paper, HDPE and PE-BIO films were exposed to UV-B radiation (320-280 nm) at different exposure times, 0-60 days. The effects of UV radiation in samples of HDPE and PE-BIO were characterized using infrared spectroscopy with attenuated total reflectance (ATR). The results show that the exposed materials undergo changes in their molecular structure, due to the infrared bands formed which corresponds to the photo-oxidation of HDPE and PE films when submitted to UV-B radiation.

Double-stranded DNA organization in bacteriophage heads: an alternative toroid-based model.

PubMed Central

Hud, N V

1995-01-01

Studies of the organization of double-stranded DNA within bacteriophage heads during the past four decades have produced a wealth of data. However, despite the presentation of numerous models, the true organization of DNA within phage heads remains unresolved. The observations of toroidal DNA structures in electron micrographs of phage lysates have long been cited as support for the organization of DNA in a spool-like fashion. This particular model, like all other models, has not been found to be consistent will all available data. Recently we proposed that DNA within toroidal condensates produced in vitro is organized in a manner significantly different from that suggested by the spool model. This new toroid model has allowed the development of an alternative model for DNA organization within bacteriophage heads that is consistent with a wide range of biophysical data. Here we propose that bacteriophage DNA is packaged in a toroid that is folded into a highly compact structure. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 PMID:8534805

Apparatus for efficient sidewall containment of molten metal with horizontal alternating magnetic fields utilizing a ferromagnetic dam

DOEpatents

Praeg, W.F.

1997-02-11

An apparatus is disclosed for casting sheets of metal from molten metal. The apparatus includes a containment structure having an open side, a horizontal alternating magnetic field generating structure and a ferromagnetic dam. The magnetic field and the ferromagnetic dam contain the molten metal from leaking out side portions of the open side of the containment structure. 25 figs.

Micro-endoscopic ear anatomy of guinea pig applied to experimental surgery.

PubMed

Barros, Bruno Borges de Carvalho; Andrade, José Santos Cruz de; Garcia, Leandro Borborema; Pifaia, Gustavo Ribeiro; Cruz, Oswaldo Laércio Mendonça; Onishi, Ektor Tsuneo; Penido, Norma de Oliveira

2014-01-01

To describe topographic and endoscopic anatomy of guinea pig ear for development of surgical approaches in experimental studies. Experimental study. Eight adult guinea pigs (Cavia porcellus) were used in this study. Four animals were described through endoscopic view and four animals were used to describe topographic anatomy. The main structures of middle ear were well identified through endoscopy view: oval and round window, ossicles and vascular structures. Temporal bone position, landmarks and its relations to skull are perceived with topographic description. Topographic anatomic description allowed exposition of temporal bone relations for external surgical approaches. Alternatively, grooves and middle ear structures were identified and may be used to transcanal accesses.

The European Partnership for Alternative Approaches to Animal Testing (EPAA): promoting alternative methods in Europe and beyond.

PubMed

Cozigou, Gwenole; Crozier, Jonathan; Hendriksen, Coenraad; Manou, Irene; Ramirez-Hernandez, Tzutzuy; Weissenhorn, Renate

2015-03-01

Here in we introduce the European Partnership for Alternative Approaches to Animal Testing (EPAA) and its activities, which are focused on international cooperation toward alternative methods. The EPAA is one of the leading organizations in Europe for the promotion of alternative approaches to animal testing. Its innovative public-private partnership structure enables a consensus-driven dialogue across 7 industry sectors to facilitate interaction between regulators and regulated stakeholders. Through a brief description of EPAA's activities and organizational structure, we first articulate the value of this collaboration; we then focus on 2 key projects driven by EPAA. The first project aims to address research gaps on stem cells for safety testing, whereas the second project strives for an approach toward demonstration of consistency in vaccine batch release testing. We highlight the growing need for harmonization of international acceptance and implementation of alternative approaches and for increased international collaboration to foster progress on nonanimal alternatives.

Organosilicon Polymers as Precursors for Silicon Containing Ceramics: Recent Developments.

DTIC Science & Technology

1987-08-14

the polymer to a ceramic material, hopefully of the desired composition . In the latter alternative, shrinkage during pyrolysis should not be great...carbon-carbon composite materials. In order to have a useful preceramic polymer . considerations of structure and reactivitv are of paramount importance...process so that on pyrolysis non-volatile, three-dimensional networks (which lead to maximum weight retention) are formed. Thus. preceramic polymer

Informal Learning and Transfer of Learning: How New Trade and Industrial Teachers Perceive Their Professional Growth and Development

ERIC Educational Resources Information Center

Burns, Janet Zaleski

2008-01-01

This study is an examination of the extent to which new inservice trade and industrial (T&I) teachers, enrolled in an alternative certification program, engaged in formal learning through structured experiences and informal learning related to 25 core competencies at their school (work) site. The study also investigated the degree to which the new…

Polymers application in proton exchange membranes for fuel cells (PEMFCs)

NASA Astrophysics Data System (ADS)

Walkowiak-Kulikowska, Justyna; Wolska, Joanna; Koroniak, Henryk

2017-07-01

This review presents the most important research on alternative polymer membranes with ionic groups attached, provides examples of materials with a well-defined chemical structure that are described in the literature. Furthermore, it elaborates on the synthetic methods used for preparing PEMs, the current status of fuel cell technology and its application. It also briefly discusses the development of the PEMFC market.

Development of the Mission Skills Assessment and Evidence of Its Reliability and Internal Structure. Research Report. ETS RR-16-19

ERIC Educational Resources Information Center

Petway, Kevin T., II; Rikoon, Samuel H.; Brenneman, Meghan W.; Burrus, Jeremy; Roberts, Richard D.

2016-01-01

The Mission Skills Assessment (MSA) is an online assessment that targets 6 noncognitive constructs: creativity, curiosity, ethics, resilience, teamwork, and time management. Each construct is measured by means of a student self-report scale, a student alternative scale (e.g., situational judgment test), and a teacher report scale. Use of the MSA…

A Lesson Plan to Develop Structured Discussion of the Benefits and Disadvantages of Selected Plastics Using the Product-Testing Method

ERIC Educational Resources Information Center

Burmeister, Mareike; Eilks, Ingo

2014-01-01

People use many different products made from plastics every day. But conventional plastics such as polyvinyl chloride (PVC) do not always have a good reputation in society at large. Bioplastics such as thermoplastic starch (TPS) promise to be better alternatives but are they really better than conventional plastics? This article presents a new…

The Stability and Structure of Career Decision-Making Profiles: A 1-Year Follow-Up

ERIC Educational Resources Information Center

Gati, Itamar; Levin, Nimrod

2012-01-01

The Career Decision-Making Profile (CDMP) questionnaire is a multidimensional measure of the way individuals make career decisions, developed as an alternative to the single, most-dominant trait approach. Using a sample of freshmen students, the 2-week reliability (N = 273) and 1-year stability (N = 182) of the CDMP was tested for each of the 12…

Impact of parity on ewe vaginal mechanical properties relative to the nonhuman primate and rodent.

PubMed

Knight, Katrina M; Moalli, Pamela A; Nolfi, Alexis; Palcsey, Stacy; Barone, William R; Abramowitch, Steven D

2016-08-01

Parity is the leading risk factor for the development of pelvic organ prolapse. To assess the impact of pregnancy and delivery on vaginal tissue, researchers commonly use nonhuman primate (NHP) and rodent models. The purpose of this study was to evaluate the ewe as an alternative model by investigating the impact of parity on the ewe vaginal mechanical properties and collagen structure. Mechanical properties of 15 nulliparous and parous ewe vaginas were determined via uniaxial tensile tests. Collagen content was determined by hydroxyproline assay and collagen fiber thickness was analyzed using picrosirius red staining. Outcome measures were compared using Independent samples t or Mann-Whitney U tests. ANOVA (Gabriel's pairwise post-hoc test) or the Welch Alternative for the F-ratio (Games Howell post-hoc test) was used to compare data with previously published NHP and rodent data. Vaginal tissue from the nulliparous ewe had a higher tangent modulus and tensile strength compared with the parous ewe (p < 0.025). The parous ewe vagina elongated 42 % more than the nulliparous ewe vagina (p = 0.015). No significant differences were observed in collagen structure among ewe vaginas. The tangent modulus of the nulliparous ewe vagina was not different from that of the NHP or rodent (p = 0.290). Additionally, the tangent moduli of the parous ewe and NHP vaginas did not differ (p = 0.773). Parity has a negative impact on the mechanical properties of the ewe vagina, as also observed in the NHP. The ewe may serve as an alternative model for studying parity and ultimately prolapse development.

Documenting the decision structure in software development

NASA Technical Reports Server (NTRS)

Wild, J. Christian; Maly, Kurt; Shen, Stewart N.

1990-01-01

Current software development paradigms focus on the products of the development process. Much of the decision making process which produces these products is outside the scope of these paradigms. The Decision-Based Software Development (DBSD) paradigm views the design process as a series of interrelated decisions which involve the identification and articulation of problems, alternates, solutions and justifications. Decisions made by programmers and analysts are recorded in a project data base. Unresolved problems are also recorded and resources for their resolution are allocated by management according to the overall development strategy. This decision structure is linked to the products affected by the relevant decision and provides a process oriented view of the resulted system. Software maintenance uses this decision view of the system to understand the rationale behind the decisions affecting the part of the system to be modified. D-HyperCase, a prototype Decision-Based Hypermedia System is described and results of applying the DBSD approach during its development are presented.

Receptor-based 3D-QSAR in Drug Design: Methods and Applications in Kinase Studies.

PubMed

Fang, Cheng; Xiao, Zhiyan

2016-01-01

Receptor-based 3D-QSAR strategy represents a superior integration of structure-based drug design (SBDD) and three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. It combines the accurate prediction of ligand poses by the SBDD approach with the good predictability and interpretability of statistical models derived from the 3D-QSAR approach. Extensive efforts have been devoted to the development of receptor-based 3D-QSAR methods and two alternative approaches have been exploited. One associates with computing the binding interactions between a receptor and a ligand to generate structure-based descriptors for QSAR analyses. The other concerns the application of various docking protocols to generate optimal ligand poses so as to provide reliable molecular alignments for the conventional 3D-QSAR operations. This review highlights new concepts and methodologies recently developed in the field of receptorbased 3D-QSAR, and in particular, covers its application in kinase studies.

Innovative Ingredients and Emerging Technologies for Controlling Ice Recrystallization, Texture, and Structure Stability in Frozen Dairy Desserts: A Review.

PubMed

Soukoulis, Christos; Fisk, Ian

2016-11-17

Over the past decade, ice cream manufacturers have developed a strong understanding of the functionality of key ingredients and processing, developing effective explanations for the link between structure forming agents, stability mechanisms, and perceived quality. Increasing demand for products perceived as healthier/more natural with minimal processing has identified a number of new tools to improve quality and storage stability of frozen dairy desserts. Ingredients such as dietary fiber, polysaccharides, prebiotics, alternate sweeteners, fat sources rich in unsaturated fatty acids and ice strucsturing proteins (ISP) have been successfully applied as cryoprotective, texturizing, and structuring agents. Emerging minimal processing technologies including hydrostatic pressure processing, ultrasonic or high pressure assisted freezing, low temperature extrusion and enzymatically induced biopolymers crosslinking have been evaluated for their ability to improve colloidal stability, texture and sensory quality. It is therefore timely for a comprehensive review.

Sensitivity method for integrated structure/active control law design

NASA Technical Reports Server (NTRS)

Gilbert, Michael G.

1987-01-01

The development is described of an integrated structure/active control law design methodology for aeroelastic aircraft applications. A short motivating introduction to aeroservoelasticity is given along with the need for integrated structures/controls design algorithms. Three alternative approaches to development of an integrated design method are briefly discussed with regards to complexity, coordination and tradeoff strategies, and the nature of the resulting solutions. This leads to the formulation of the proposed approach which is based on the concepts of sensitivity of optimum solutions and multi-level decompositions. The concept of sensitivity of optimum is explained in more detail and compared with traditional sensitivity concepts of classical control theory. The analytical sensitivity expressions for the solution of the linear, quadratic cost, Gaussian (LQG) control problem are summarized in terms of the linear regulator solution and the Kalman Filter solution. Numerical results for a state space aeroelastic model of the DAST ARW-II vehicle are given, showing the changes in aircraft responses to variations of a structural parameter, in this case first wing bending natural frequency.

Dynamic environmental control mechanisms for pneumatic foil constructions

NASA Astrophysics Data System (ADS)

Flor, Jan-Frederik; Wu, Yupeng; Beccarelli, Paolo; Chilton, John

2017-11-01

Membrane and foil structures have become over the last decades an attractive alternative to conventional materials and building systems with increasing implementation in different typologies and scale. The development of transparent, light, flexible and resistant materials like Ethylene Tetrafluoroethylene (ETFE) has triggered a rethinking of the building envelope in the building industry towards lightweight systems. ETFE foil cushions have proven to fulfil the design requirements in terms of structural efficiency and aesthetic values. But the strategies to satisfy increasing demands of energy efficiency and comfort conditions are still under development. The prediction and manipulation of the thermo-optical behaviour of ETFE foil cushion structures currently remain as one of the main challenges for designers and manufacturers. This paper reviews ongoing research regarding the control of the thermo-optical performance of ETFE cushion structures and highlights challenges and possible improvements. An overview of different dynamic and responsive environmental control mechanisms for multilayer foil constructions is provided and the state of the art in building application outlined by the discussion of case studies.

Experimental Directory Structure (Exdir): An Alternative to HDF5 Without Introducing a New File Format

PubMed Central

Dragly, Svenn-Arne; Hobbi Mobarhan, Milad; Lepperød, Mikkel E.; Tennøe, Simen; Fyhn, Marianne; Hafting, Torkel; Malthe-Sørenssen, Anders

2018-01-01

Natural sciences generate an increasing amount of data in a wide range of formats developed by different research groups and commercial companies. At the same time there is a growing desire to share data along with publications in order to enable reproducible research. Open formats have publicly available specifications which facilitate data sharing and reproducible research. Hierarchical Data Format 5 (HDF5) is a popular open format widely used in neuroscience, often as a foundation for other, more specialized formats. However, drawbacks related to HDF5's complex specification have initiated a discussion for an improved replacement. We propose a novel alternative, the Experimental Directory Structure (Exdir), an open specification for data storage in experimental pipelines which amends drawbacks associated with HDF5 while retaining its advantages. HDF5 stores data and metadata in a hierarchy within a complex binary file which, among other things, is not human-readable, not optimal for version control systems, and lacks support for easy access to raw data from external applications. Exdir, on the other hand, uses file system directories to represent the hierarchy, with metadata stored in human-readable YAML files, datasets stored in binary NumPy files, and raw data stored directly in subdirectories. Furthermore, storing data in multiple files makes it easier to track for version control systems. Exdir is not a file format in itself, but a specification for organizing files in a directory structure. Exdir uses the same abstractions as HDF5 and is compatible with the HDF5 Abstract Data Model. Several research groups are already using data stored in a directory hierarchy as an alternative to HDF5, but no common standard exists. This complicates and limits the opportunity for data sharing and development of common tools for reading, writing, and analyzing data. Exdir facilitates improved data storage, data sharing, reproducible research, and novel insight from interdisciplinary collaboration. With the publication of Exdir, we invite the scientific community to join the development to create an open specification that will serve as many needs as possible and as a foundation for open access to and exchange of data. PMID:29706879

Experimental Directory Structure (Exdir): An Alternative to HDF5 Without Introducing a New File Format.

PubMed

Dragly, Svenn-Arne; Hobbi Mobarhan, Milad; Lepperød, Mikkel E; Tennøe, Simen; Fyhn, Marianne; Hafting, Torkel; Malthe-Sørenssen, Anders

2018-01-01

Natural sciences generate an increasing amount of data in a wide range of formats developed by different research groups and commercial companies. At the same time there is a growing desire to share data along with publications in order to enable reproducible research. Open formats have publicly available specifications which facilitate data sharing and reproducible research. Hierarchical Data Format 5 (HDF5) is a popular open format widely used in neuroscience, often as a foundation for other, more specialized formats. However, drawbacks related to HDF5's complex specification have initiated a discussion for an improved replacement. We propose a novel alternative, the Experimental Directory Structure (Exdir), an open specification for data storage in experimental pipelines which amends drawbacks associated with HDF5 while retaining its advantages. HDF5 stores data and metadata in a hierarchy within a complex binary file which, among other things, is not human-readable, not optimal for version control systems, and lacks support for easy access to raw data from external applications. Exdir, on the other hand, uses file system directories to represent the hierarchy, with metadata stored in human-readable YAML files, datasets stored in binary NumPy files, and raw data stored directly in subdirectories. Furthermore, storing data in multiple files makes it easier to track for version control systems. Exdir is not a file format in itself, but a specification for organizing files in a directory structure. Exdir uses the same abstractions as HDF5 and is compatible with the HDF5 Abstract Data Model. Several research groups are already using data stored in a directory hierarchy as an alternative to HDF5, but no common standard exists. This complicates and limits the opportunity for data sharing and development of common tools for reading, writing, and analyzing data. Exdir facilitates improved data storage, data sharing, reproducible research, and novel insight from interdisciplinary collaboration. With the publication of Exdir, we invite the scientific community to join the development to create an open specification that will serve as many needs as possible and as a foundation for open access to and exchange of data.

Piezoelectric energy harvesting from an L-shaped beam-mass structure

NASA Astrophysics Data System (ADS)

Erturk, Alper; Renno, Jamil M.; Inman, Daniel J.

2008-03-01

Cantilevered piezoelectric harvesters have been extensively considered in the energy harvesting literature. Mostly, a traditional cantilevered beam with one or more piezoceramic layers is located on a vibrating host structure. Motion of the host structure results in vibrations of the harvester beam and that yields an alternating voltage output. As an alternative to classical cantilevered beams, this paper presents a novel harvesting device; a flexible L-shaped beam-mass structure that can be tuned to have a two-to-one internal resonance to a primary resonance ω II ≅ 2ω I which is not possible for classical cantilevers). The L-shaped structure has been well investigated in the literature of nonlinear dynamics since the two-to-one internal resonance, along with the consideration of quadratic nonlinearities, may yield modal energy exchange (for excitation frequency ω≅ ω Ior the so-called saturation phenomenon (for ω≅ω II). As a part of our ongoing research on piezoelectric energy harvesting, we are investigating the possibility of improving the electrical outputs in energy harvesting by employing these features of the L-shaped structure. This paper aims to introduce the idea, describes the important features of the L-shaped harvester configuration and develops a linear distributed parameter model for predicting the electromechanically coupled response. In addition, this work proposes a direct application of the L-shaped piezoelectric energy harvester configuration for use as landing gears in unmanned air vehicle applications.

Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms.

PubMed

Yap, Karen; Xiao, Yixin; Friedman, Brad A; Je, H Shawn; Makeyev, Eugene V

2016-05-10

Alternative splicing (AS) is an important source of proteome diversity in eukaryotes. However, how this affects protein repertoires at a single-cell level remains an open question. Here, we show that many 3'-terminal exons are persistently co-expressed with their alternatives in mammalian neurons. In an important example of this scenario, cell polarity gene Cdc42, a combination of polypyrimidine tract-binding, protein-dependent, and constitutive splicing mechanisms ensures a halfway switch from the general (E7) to the neuron-specific (E6) alternative 3'-terminal exon during neuronal differentiation. Perturbing the nearly equimolar E6/E7 ratio in neurons results in defects in both axonal and dendritic compartments and suggests that Cdc42E7 is involved in axonogenesis, whereas Cdc42E6 is required for normal development of dendritic spines. Thus, co-expression of a precise blend of functionally distinct splice isoforms rather than a complete switch from one isoform to another underlies proper structural and functional polarization of neurons. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Coal gasification systems engineering and analysis, volume 2

NASA Technical Reports Server (NTRS)

1980-01-01

The major design related features of each generic plant system were characterized in a catalog. Based on the catalog and requirements data, approximately 17 designs and cost estimates were developed for MBG and alternate products. A series of generic trade studies was conducted to support all of the design studies. A set of cost and programmatic analyses were conducted to supplement the designs. The cost methodology employed for the design and sensitivity studies was documented and implemented in a computer program. Plant design and construction schedules were developed for the K-T, Texaco, and B&W MBG plant designs. A generic work breakdown structure was prepared, based on the K-T design, to coincide with TVA's planned management approach. An extensive set of cost sensitivity analyses was completed for K-T, Texaco, and B&W design. Product price competitiveness was evaluated for MBG and the alternate products. A draft management policy and procedures manual was evaluated. A supporting technology development plan was developed to address high technology risk issues. The issues were identified and ranked in terms of importance and tractability, and a plan developed for obtaining data or developing technology required to mitigate the risk.

Alternative Fuels Data Center: Hydrogen Research and Development

Science.gov Websites

Research and Development to someone by E-mail Share Alternative Fuels Data Center: Hydrogen Research and Development on Facebook Tweet about Alternative Fuels Data Center: Hydrogen Research and Development on Twitter Bookmark Alternative Fuels Data Center: Hydrogen Research and Development on Google

An alternative to Guyan reduction of finite-element models

NASA Technical Reports Server (NTRS)

Lin, Jiguan Gene

1988-01-01

Structural modeling is a key part of structural system identification for large space structures. Finite-element structural models are commonly used in practice because of their general applicability and availability. The initial models generated by using a standard computer program such as NASTRAN, ANSYS, SUPERB, STARDYNE, STRUDL, etc., generally contain tens of thousands of degrees of freedom. The models must be reduced for purposes of identification. Not only does the magnitude of the identification effort grow exponentially as a function of the number of degrees of freedom, but numerical procedures may also break down because of accumulated round-off errors. Guyan reduction is usually applied after a static condensation. Misapplication of Guyan reduction can lead to serious modeling errors. It is quite unfortunate and disappointing, since the accuracy of the original detailed finite-element model one tries very hard to achieve is lost by the reduction. First, why and how Guyan reduction always causes loss of accuracy is examined. An alternative approach is then introduced. The alternative can be thought of as an improvement of Guyan reduction, the Rayleigh-Ritz method, and in particular the recent algorithm of Wilson, Yuan, and Dickens. Unlike Guyan reduction, the use of the alternative does not need any special insight, experience, or skill for partitioning the structural degrees of freedom. In addition to model condensation, this alternative approach can also be used for predicting analytically, quickly, and economically, what are those structural modes that are excitable by a force actuator at a given trial location. That is, in the excitation of the structural modes for identification, it can be used for guiding the placement of the force actuators.

Utilizing interview and self-report assessment of the Five-Factor Model to examine convergence with the alternative model for personality disorders.

PubMed

Helle, Ashley C; Trull, Timothy J; Widiger, Thomas A; Mullins-Sweatt, Stephanie N

2017-07-01

An alternative model for personality disorders is included in Section III (Emerging Models and Measures) of Diagnostic and Statistical Manual of Mental Disorders, (5th ed.; DSM-5). The DSM-5 dimensional trait model is an extension of the Five-Factor Model (FFM; American Psychiatric Association, 2013). The Personality Inventory for DSM-5 (PID-5) assesses the 5 domains and 25 traits in the alternative model. The current study expands on recent research to examine the relationship of the PID-5 with an interview measure of the FFM. The Structured Interview for the Five Factor Model of Personality (SIFFM) assesses the 5 bipolar domains and 30 facets of the FFM. Research has indicated that the SIFFM captures maladaptive aspects of personality (as well as adaptive). The SIFFM, NEO PI-R, and PID-5 were administered to participants to examine their respective convergent and discriminant validity. Results provide evidence for the convergence of the 2 models using self-report and interview measures of the FFM. Clinical implications and future directions are discussed, particularly a call for the development of a structured interview for the assessment of the DSM-5 dimensional trait model. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Road safety forecasts in five European countries using structural time series models.

PubMed

Antoniou, Constantinos; Papadimitriou, Eleonora; Yannis, George

2014-01-01

Modeling road safety development is a complex task and needs to consider both the quantifiable impact of specific parameters as well as the underlying trends that cannot always be measured or observed. The objective of this research is to apply structural time series models for obtaining reliable medium- to long-term forecasts of road traffic fatality risk using data from 5 countries with different characteristics from all over Europe (Cyprus, Greece, Hungary, Norway, and Switzerland). Two structural time series models are considered: (1) the local linear trend model and the (2) latent risk time series model. Furthermore, a structured decision tree for the selection of the applicable model for each situation (developed within the Road Safety Data, Collection, Transfer and Analysis [DaCoTA] research project, cofunded by the European Commission) is outlined. First, the fatality and exposure data that are used for the development of the models are presented and explored. Then, the modeling process is presented, including the model selection process, introduction of intervention variables, and development of mobility scenarios. The forecasts using the developed models appear to be realistic and within acceptable confidence intervals. The proposed methodology is proved to be very efficient for handling different cases of data availability and quality, providing an appropriate alternative from the family of structural time series models in each country. A concluding section providing perspectives and directions for future research is presented.

500 Million Americans by 2050? Alternative Projections of the U.S. Population.

ERIC Educational Resources Information Center

Ahlburg, Dennis; Vaupel, James W.

1993-01-01

Offers an alternative to the U.S. Bureau of the Consensus population projection for 2050. Discusses alternative mortality, fertility, and immigration assumptions and projection methods that use a baseline scenario of no further gains against mortality. Description of the U.S. population under alternative scenarios include changes in structure and…

Programming Language Software For Graphics Applications

NASA Technical Reports Server (NTRS)

Beckman, Brian C.

1993-01-01

New approach reduces repetitive development of features common to different applications. High-level programming language and interactive environment with access to graphical hardware and software created by adding graphical commands and other constructs to standardized, general-purpose programming language, "Scheme". Designed for use in developing other software incorporating interactive computer-graphics capabilities into application programs. Provides alternative to programming entire applications in C or FORTRAN, specifically ameliorating design and implementation of complex control and data structures typifying applications with interactive graphics. Enables experimental programming and rapid development of prototype software, and yields high-level programs serving as executable versions of software-design documentation.

"Out of the box" professional development

NASA Astrophysics Data System (ADS)

2015-04-01

At a recent AAPT meeting, I was part of a conversation about professional development that focused on conferences. We discussed the current meeting structure used by AAPT and some alternative formats. This discussion added greatly to my own understanding of new ways for teachers to receive their professional development. This conversation also began my friendship with Kelly O'Shea, a physics teacher from New York. She is also a blogger (check her out at https://kellyoshea.wordpress.com) and an innovative educator. Through my relationship with Kelly, I have grown in my own knowledge of two "out of the box" ways teachers are getting their professional development.

The performance of fine-grained and coarse-grained elastic network models and its dependence on various factors.

PubMed

Na, Hyuntae; Song, Guang

2015-07-01

In a recent work we developed a method for deriving accurate simplified models that capture the essentials of conventional all-atom NMA and identified two best simplified models: ssNMA and eANM, both of which have a significantly higher correlation with NMA in mean square fluctuation calculations than existing elastic network models such as ANM and ANMr2, a variant of ANM that uses the inverse of the squared separation distances as spring constants. Here, we examine closely how the performance of these elastic network models depends on various factors, namely, the presence of hydrogen atoms in the model, the quality of input structures, and the effect of crystal packing. The study reveals the strengths and limitations of these models. Our results indicate that ssNMA and eANM are the best fine-grained elastic network models but their performance is sensitive to the quality of input structures. When the quality of input structures is poor, ANMr2 is a good alternative for computing mean-square fluctuations while ANM model is a good alternative for obtaining normal modes. © 2015 Wiley Periodicals, Inc.

Optical Fiber Sensors for Aircraft Structural Health Monitoring

PubMed Central

García, Iker; Zubia, Joseba; Durana, Gaizka; Aldabaldetreku, Gotzon; Illarramendi, María Asunción; Villatoro, Joel

2015-01-01

Aircraft structures require periodic and scheduled inspection and maintenance operations due to their special operating conditions and the principles of design employed to develop them. Therefore, structural health monitoring has a great potential to reduce the costs related to these operations. Optical fiber sensors applied to the monitoring of aircraft structures provide some advantages over traditional sensors. Several practical applications for structures and engines we have been working on are reported in this article. Fiber Bragg gratings have been analyzed in detail, because they have proved to constitute the most promising technology in this field, and two different alternatives for strain measurements are also described. With regard to engine condition evaluation, we present some results obtained with a reflected intensity-modulated optical fiber sensor for tip clearance and tip timing measurements in a turbine assembled in a wind tunnel. PMID:26134107

Optical Fiber Sensors for Aircraft Structural Health Monitoring.

PubMed

García, Iker; Zubia, Joseba; Durana, Gaizka; Aldabaldetreku, Gotzon; Illarramendi, María Asunción; Villatoro, Joel

2015-06-30

Aircraft structures require periodic and scheduled inspection and maintenance operations due to their special operating conditions and the principles of design employed to develop them. Therefore, structural health monitoring has a great potential to reduce the costs related to these operations. Optical fiber sensors applied to the monitoring of aircraft structures provide some advantages over traditional sensors. Several practical applications for structures and engines we have been working on are reported in this article. Fiber Bragg gratings have been analyzed in detail, because they have proved to constitute the most promising technology in this field, and two different alternatives for strain measurements are also described. With regard to engine condition evaluation, we present some results obtained with a reflected intensity-modulated optical fiber sensor for tip clearance and tip timing measurements in a turbine assembled in a wind tunnel.

Recent developments in the structural design and optimization of ITER neutral beam manifold

NASA Astrophysics Data System (ADS)

Chengzhi, CAO; Yudong, PAN; Zhiwei, XIA; Bo, LI; Tao, JIANG; Wei, LI

2018-02-01

This paper describes a new design of the neutral beam manifold based on a more optimized support system. A proposed alternative scheme has presented to replace the former complex manifold supports and internal pipe supports in the final design phase. Both the structural reliability and feasibility were confirmed with detailed analyses. Comparative analyses between two typical types of manifold support scheme were performed. All relevant results of mechanical analyses for typical operation scenarios and fault conditions are presented. Future optimization activities are described, which will give useful information for a refined setting of components in the next phase.

Two-dimensional finite-element analyses of simulated rotor-fragment impacts against rings and beams compared with experiments

NASA Technical Reports Server (NTRS)

Stagliano, T. R.; Witmer, E. A.; Rodal, J. J. A.

1979-01-01

Finite element modeling alternatives as well as the utility and limitations of the two dimensional structural response computer code CIVM-JET 4B for predicting the transient, large deflection, elastic plastic, structural responses of two dimensional beam and/or ring structures which are subjected to rigid fragment impact were investigated. The applicability of the CIVM-JET 4B analysis and code for the prediction of steel containment ring response to impact by complex deformable fragments from a trihub burst of a T58 turbine rotor was studied. Dimensional analysis considerations were used in a parametric examination of data from engine rotor burst containment experiments and data from sphere beam impact experiments. The use of the CIVM-JET 4B computer code for making parametric structural response studies on both fragment-containment structure and fragment-deflector structure was illustrated. Modifications to the analysis/computation procedure were developed to alleviate restrictions.

Cutoff Criteria for Fit Indexes in Covariance Structure Analysis: Conventional Criteria versus New Alternatives.

ERIC Educational Resources Information Center

Hu, Li-tze; Bentler, Peter M.

1999-01-01

The adequacy of "rule of thumb" conventional cutoff criteria and several alternatives for fit indices in covariance structure analysis was evaluated through simulation. Analyses suggest that, for all recommended fit indexes except one, a cutoff criterion greater than (or sometimes smaller than) the conventional rule of thumb is required…

Beta structures of alternating polypeptides and their possible prebiotic significance

NASA Technical Reports Server (NTRS)

Brack, A.; Orgel, L. E.

1975-01-01

A survey of the commonest amino acids formed in prebiotic conditions suggests that the earliest form of genetic coding may have specified polypeptides with a strong tendency to form stable beta-sheet structures. Poly(Val-Lys), like other polypeptides in which hydrophobic and hydrophilic residues alternate, tends to form beta structures. It is shown that bilayers with a hydrophobic interior and a hydrophilic exterior may be present in aqueous solution.

[Extraction and antioxidant activity of collagen from elephant skin, pig skin and fish scales].

PubMed

Li, Chunnan; Sun, Jiaming; Zhang, Hui

2011-08-01

To study collagen structure of the traditional Chinese medicine elephant skin and the proposed alternatives such as pig skin, fish scale, and antioxidant activity. Orthogonal experimental design method was employed to determine the optimal extraction condition of collagen from the elephant skin, and the structure and content of collagen of proposed alternatives were compared, their scavenging ability were determined by salicylic acid. Collagen extracted from elephant skin with the optimal conditions was the structural integrity and good quality first time, and collagen structure of the elephant skin was similar to the proposed alternatives. Free radical scavenging capacity of collagen, values of IC50, were 0.51 g x L(-1) of elephant skin, 0.60 g x L(-1) of pig skin and 0.42 g x L(-1) of fish scale. By comparing and identification of proteins that the collagen of elephant skin is type I collagen, with a strong antioxidant capacity, is the active ingredients of elephant skin. It provides a further study of alternatives as an important reference.

In silico design of ligand triggered RNA switches.

PubMed

Findeiß, Sven; Hammer, Stefan; Wolfinger, Michael T; Kühnl, Felix; Flamm, Christoph; Hofacker, Ivo L

2018-04-13

This contribution sketches a work flow to design an RNA switch that is able to adapt two structural conformations in a ligand-dependent way. A well characterized RNA aptamer, i.,e., knowing its K d and adaptive structural features, is an essential ingredient of the described design process. We exemplify the principles using the well-known theophylline aptamer throughout this work. The aptamer in its ligand-binding competent structure represents one structural conformation of the switch while an alternative fold that disrupts the binding-competent structure forms the other conformation. To keep it simple we do not incorporate any regulatory mechanism to control transcription or translation. We elucidate a commonly used design process by explicitly dissecting and explaining the necessary steps in detail. We developed a novel objective function which specifies the mechanistics of this simple, ligand-triggered riboswitch and describe an extensive in silico analysis pipeline to evaluate important kinetic properties of the designed sequences. This protocol and the developed software can be easily extended or adapted to fit novel design scenarios and thus can serve as a template for future needs. Copyright © 2018. Published by Elsevier Inc.

Decision Support System for Coastal Protection Layout Design (DSS4CPD) Using Genetic Algorithm (ga) and Multicriteria Analysis (mca)

NASA Astrophysics Data System (ADS)

Jinchai, Phinai; Chittaladakorn, Suwatana

This research has its objective to develop the decision support system on GIS to be used in the coastal erosion protection management. The developed model in this research is called Decision Support System for Coastal Protection Layout Design (DSS4CPD). It has created both for systematic protection and solution measures to the problem by using Genetic Algorithm (GA) and Multicriteria Analysis (MCA) for finding the coastal structure layout optimal solution. In this research, three types of coastal structures were used as structure alternatives for the layout, which are seawall, breakwater, and groin. The coastal area in Nakornsrithammaraj, Thailand was used as the case study. The studied result has found the appropriate position of coastal structures considering the suitable rock size relied on the wave energy, and the appropriate coastal structure position based on the wave breaking line. Using GA and MCA in DSS4CPD, it found the best layout in this project. This DSS4CPD will be used by the authorized decision makers to find the most suitable erosion problem solution.

Open-Lattice Composite Design Strengthens Structures

NASA Technical Reports Server (NTRS)

2007-01-01

Advanced composite materials and designs could eventually be applied as the framework for spacecraft or extraterrestrial constructions for long-term space habitation. One such structure in which NASA has made an investment is the IsoTruss grid structure, an extension of a two-dimensional "isogrid" concept originally developed at McDonnell Douglas Astronautics Company, under contract to NASA's Marshall Space Flight Center in the early 1970s. IsoTruss is a lightweight and efficient alternative to monocoque composite structures, and can be produced in a manner that involves fairly simple techniques. The technology was developed with support from NASA to explore space applications, and is garnering global attention because it is extremely lightweight; as much as 12 times stronger than steel; inexpensive to manufacture, transport, and install; low-maintenance; and is fully recyclable. IsoTruss is expected to see application as utility poles and meteorological towers, for the aforementioned reasons and because its design offers superior wind resistance and is less susceptible to breaking and woodpeckers. Other applications, such as reinforcement for concrete structures, stand-alone towers, sign supports, prostheses, irrigation equipment, and sporting goods are being explored

Admixture compatibility of alternative supplementary cementitious materials for pavement and structural concrete.

DOT National Transportation Integrated Search

2014-08-01

The objectives of this research project were: (1) to gain a better understanding about the interaction among alternative SCMS and : chemical admixtures in Portland cement mixtures; and (2) to facilitate implementation of alternative SCMs in transport...

Alternative Fuels Data Center: Natural Gas Fueling Infrastructure

Science.gov Websites

Development Infrastructure Development to someone by E-mail Share Alternative Fuels Data Center : Natural Gas Fueling Infrastructure Development on Facebook Tweet about Alternative Fuels Data Center : Natural Gas Fueling Infrastructure Development on Twitter Bookmark Alternative Fuels Data Center: Natural

Understanding the General Packing Rearrangements Required for Successful Template Based Modeling of Protein Structure from a CASP Experiment

PubMed Central

Day, Ryan; Joo, Hyun; Chavan, Archana; Lennox, Kristin P.; Chen, Ann; Dahl, David B.; Vannucci, Marina; Tsai, Jerry W.

2012-01-01

As an alternative to the common template based protein structure prediction methods based on main-chain position, a novel side-chain centric approach has been developed. Together with a Bayesian loop modeling procedure and a combination scoring function, the Stone Soup algorithm was applied to the CASP9 set of template based modeling targets. Although the method did not generate as large of perturbations to the template structures as necessary, the analysis of the results gives unique insights into the differences in packing between the target structures and their templates. Considerable variation in packing is found between target and template structures even when the structures are close, and this variation is found due to 2 and 3 body packing interactions. Outside the inherent restrictions in packing representation of the PDB, the first steps in correctly defining those regions of variable packing have been mapped primarily to local interactions, as the packing at the secondary and tertiary structure are largely conserved. Of the scoring functions used, a loop scoring function based on water structure exhibited some promise for discrimination. These results present a clear structural path for further development of a side-chain centered approach to template based modeling. PMID:23266765

Understanding the general packing rearrangements required for successful template based modeling of protein structure from a CASP experiment.

PubMed

Day, Ryan; Joo, Hyun; Chavan, Archana C; Lennox, Kristin P; Chen, Y Ann; Dahl, David B; Vannucci, Marina; Tsai, Jerry W

2013-02-01

As an alternative to the common template based protein structure prediction methods based on main-chain position, a novel side-chain centric approach has been developed. Together with a Bayesian loop modeling procedure and a combination scoring function, the Stone Soup algorithm was applied to the CASP9 set of template based modeling targets. Although the method did not generate as large of perturbations to the template structures as necessary, the analysis of the results gives unique insights into the differences in packing between the target structures and their templates. Considerable variation in packing is found between target and template structures even when the structures are close, and this variation is found due to 2 and 3 body packing interactions. Outside the inherent restrictions in packing representation of the PDB, the first steps in correctly defining those regions of variable packing have been mapped primarily to local interactions, as the packing at the secondary and tertiary structure are largely conserved. Of the scoring functions used, a loop scoring function based on water structure exhibited some promise for discrimination. These results present a clear structural path for further development of a side-chain centered approach to template based modeling. Copyright © 2012 Elsevier Ltd. All rights reserved.

Stereochemistry and solvent role in protein folding: nuclear magnetic resonance and molecular dynamics studies of poly-L and alternating-L,D homopolypeptides in dimethyl sulfoxide.

PubMed

Srivastava, Kinshuk Raj; Kumar, Anil; Goyal, Bhupesh; Durani, Susheel

2011-05-26

The competing interactions folding and unfolding protein structure remain obscure. Using homopolypeptides, we ask if poly-L structure may have a role. We mutate the structure to alternating-L,D stereochemistry and substitute water as the fold-promoting solvent with methanol and dimethyl sulfoxide (DMSO) as the fold-denaturing solvents. Circular dichroism and molecular dynamics established previously that, while both isomers were folded in water, the poly-L isomer was unfolded and alternating-L,D isomer folded in methanol. Nuclear magnetic resonance and molecular dynamics establish now that both isomers are unfolded in DMSO. We calculated energetics of folding-unfolding equilibrium with water and methanol as solvents. We have now calculated interactions of unfolded polypeptide structures with DMSO as solvent. Methanol was found to unfold and water fold poly-L structure as a dielectric. DMSO has now been found to unfold both poly-L and alternating-L,D structures by strong solvation of peptides to disrupt their hydrogen bonds. Accordingly, we propose that while linked peptides fold protein structure with hydrogen bonds they unfold the structure electrostatically due to the stereochemical effect of the poly-L structure. Protein folding to ordering of peptide hydrogen bonds with water as canonical solvent may thus involve two specific and independent solvent effects-one, strong screening of electrostatics of poly-L linked peptides, and two, weak dipolar solvation of peptides. Correspondingly, protein denaturation may involve two independent solvent effects-one, weak dielectric to unfold poly-L structure electrostatically, and two, strong polarity to disrupt peptide hydrogen bonds by solvation of peptides.

Review of Current State of the Art and Key Design Issues With Potential Solutions for Liquid Hydrogen Cryogenic Storage Tank Structures for Aircraft Applications

NASA Technical Reports Server (NTRS)

Mital, Subodh K.; Gyekenyesi, John Z.; Arnold, Steven M.; Sullivan, Roy M.; Manderscheid, Jane M.; Murthy, Pappu L. N.

2006-01-01

Due to its high specific energy content, liquid hydrogen (LH2) is emerging as an alternative fuel for future aircraft. As a result, there is a need for hydrogen tank storage systems, for these aircraft applications, that are expected to provide sufficient capacity for flight durations ranging from a few minutes to several days. It is understood that the development of a large, lightweight, reusable cryogenic liquid storage tank is crucial to meet the goals of and supply power to hydrogen-fueled aircraft, especially for long flight durations. This report provides an annotated review (including the results of an extensive literature review) of the current state of the art of cryogenic tank materials, structural designs, and insulation systems along with the identification of key challenges with the intent of developing a lightweight and long-term storage system for LH2. The broad classes of insulation systems reviewed include foams (including advanced aerogels) and multilayer insulation (MLI) systems with vacuum. The MLI systems show promise for long-term applications. Structural configurations evaluated include single- and double-wall constructions, including sandwich construction. Potential wall material candidates are monolithic metals as well as polymer matrix composites and discontinuously reinforced metal matrix composites. For short-duration flight applications, simple tank designs may suffice. Alternatively, for longer duration flight applications, a double-wall construction with a vacuum-based insulation system appears to be the most optimum design. The current trends in liner material development are reviewed in the case that a liner is required to minimize or eliminate the loss of hydrogen fuel through permeation.

Space station operations task force. Panel 4 report: Management integration

NASA Technical Reports Server (NTRS)

1987-01-01

The Management Integration Panel of the Space Station Operations Task Force was chartered to provide a structure and ground rules for integrating the efforts of the other three panels and to address a number of cross cutting issues that affect all areas of space station operations. Issues addressed include operations concept implementation, alternatives development and integration process, strategic policy issues and options, and program management emphasis areas.

Robotic Waterblasting

NASA Technical Reports Server (NTRS)

2004-01-01

The Waterblast Research Cell supports development of automated systems that remove thermal protection materials and coatings from space flight hardware. These systems remove expended coatings without harsh chemicals or damaging underlying material. Potential applications of this technology include the removal of coatings from industrial machinery, aircraft, and other large structures. Use of the robot improves worker safety by reducing the exposure of persornel to high-pressure water. This technology is a proactive alternative to hazardous chemical strippers.

Development of a Nonchromate Structural Adhesive Bond Primer

DTIC Science & Technology

2014-11-01

with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE NOV 2014 2. REPORT TYPE 3. DATES...Prevent corrosion of base metal • Applied to porous anodized surface • Overcoated with non-inhibited epoxy adhesive • High adhesive bond strength...primers •Long-running surveillance of chromate-free alternatives by UTC companies shows weak corrosion inhibition • (A) strontium chromate

Electronic laboratory notebook: the academic point of view.

PubMed

Rudolphi, Felix; Goossen, Lukas J

2012-02-27

Based on a requirement analysis and alternative design considerations, a platform-independent electronic laboratory notebook (ELN) has been developed that specifically targets academic users. Its intuitive design and numerous productivity features motivate chemical researchers and students to record their data electronically. The data are stored in a highly structured form that offers substantial benefits over laboratory notebooks written on paper with regard to data retrieval, data mining, and exchange of results.

Analytical electron microscope study of the omega phase transformation in a zirconium-niobium alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zaluzec, N. J.

1979-01-01

The study of the as-quenched omega phase morphology shows that the domain size of Zr-15% Nb is on the order of 30 A. No alignment of omega domains along <222>..beta.. directions was observed and samples having undergone thermal cycling in thin foil form, did not develop a long-period structure of alternating ..beta.. and ..omega.. phases below the omega transformation temperature. (FS)

A model for evaluation of satellite population management alternatives

NASA Astrophysics Data System (ADS)

Penny, R. E., Jr.; Jones, R. K.

1983-12-01

A Q-GERT model was developed to simulate the satellite environment, including the untracked man-made population, and to calculate a probability of collision for any satellite of interest. Provision for launches, explosions, collisions (including ASAT), retrieval, reposition, and decay was made. The model is structured to easily vary the rates at which these activities occur and to observe changes in the satellite population through which a satellite of interest must travel. Variance of the rates, and the resultant change in probability of collision allows evaluation of satellite population management alternatives such as reducing launch rates or increasing retrieval of spent, but still capable of exploding, satellites. The model is proposed for use by both the USAF SPACE COMMAND and NASA.

El Paso Electric Company Diablo Substation to the US-Mexico border 115kV transmission line project. Final Environmental Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-04-01

This Environmental Assessment documents the analysis of alternative corridors for development and operation of a proposed 115 kilovolt transmission line using private lands and transporting power to the US-Mexico international border. The project will require (1) an amendment to El Paso Electric Company`s existing export authorization to transfer power across this border, and (2) a Presidential Permit for construction of the transmission line. The project would be located in Dona Ana county in southern New Mexico, approximately five miles west of El Paso, Texas. The alternative corridors, specific locations within those corridors, and structure types are identified and analyzed inmore » the environmental studies.« less

Composite Bus Structure for the SMEX/WIRE Satellite

NASA Technical Reports Server (NTRS)

Rosanova, Giulio G.

1998-01-01

In an effort to reduce the weight and optimize the structural design of the Small Explorer (SMEX) Wide-Field Infrared Explorer (WIRE) spacecraft, it has become desirable to change the material and construction from mechanically fastened aluminum structure to a fully bonded fiber-reinforced composite (FRC) structure. GSFC has developed the WIRE spacecraft structural bus design concept, including the instrument and launch vehicle requirements. The WIRE Satellite is the fifth of a series of SMEX satellites to be launched once per year. GSFC has chosen Composite Optics Inc. (COI) as the prime contractor for the development and procurement of the WIRE composite structure. The detailed design of the fully bonded FRC structure is based on COI's Short Notice Accelerated Production SATellite ("SNAPSAT") approach. SNAPSAT is a state of the art design and manufacturing technology for advanced composite materials which utilizes flat-stock detail parts bonded together to produce a final structural assembly. The structural design approach adopted for the WIRE structure provides a very viable alternative to both traditional aluminum construction as well as high tech. molded type composite structures. This approach to composite structure design is much less costly than molded or honeycomb sandwich type composite construction, but may cost slightly more than conventional aluminum construction on the subsystem level. However on the overall program level the weight saving achieved is very cost effective, since the primary objective is to allocate more mass for science payloads.

Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage

PubMed Central

Beddoes, Charlotte M.; Whitehouse, Michael R.; Briscoe, Wuge H.; Su, Bo

2016-01-01

Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are used. This results in undesirable side effects, including inadequate lubrication, wear debris, wear of the opposing articular cartilage, and weakening of the surrounding tissue. With the number of surgeries for cartilage repair increasing, a need for materials that can better mimic cartilage, and support the surrounding material in its typical function, is becoming evident. Here, we present a brief overview of the structure and properties of the hyaline cartilage and the current methods for cartilage repair. We then highlight some of the alternative materials under development as potential methods of repair; this is followed by an overview of the development of tough hydrogels. In particular, double network (DN) hydrogels are a promising replacement material, with continually improving physical properties. These hydrogels are coming closer to replicating the strength and toughness of the hyaline cartilage, while offering excellent lubrication. We conclude by highlighting several different methods of integrating replacement materials with the native joint to ensure stability and optimal behaviour. PMID:28773566

Using Ultrathin Parylene Films as an Organic Gate Insulator in Nanowire Field-Effect Transistors.

PubMed

Gluschke, J G; Seidl, J; Lyttleton, R W; Carrad, D J; Cochrane, J W; Lehmann, S; Samuelson, L; Micolich, A P

2018-06-27

We report the development of nanowire field-effect transistors featuring an ultrathin parylene film as a polymer gate insulator. The room temperature, gas-phase deposition of parylene is an attractive alternative to oxide insulators prepared at high temperatures using atomic layer deposition. We discuss our custom-built parylene deposition system, which is designed for reliable and controlled deposition of <100 nm thick parylene films on III-V nanowires standing vertically on a growth substrate or horizontally on a device substrate. The former case gives conformally coated nanowires, which we used to produce functional Ω-gate and gate-all-around structures. These give subthreshold swings as low as 140 mV/dec and on/off ratios exceeding 10 3 at room temperature. For the gate-all-around structure, we developed a novel fabrication strategy that overcomes some of the limitations with previous lateral wrap-gate nanowire transistors. Finally, we show that parylene can be deposited over chemically treated nanowire surfaces, a feature generally not possible with oxides produced by atomic layer deposition due to the surface "self-cleaning" effect. Our results highlight the potential for parylene as an alternative ultrathin insulator in nanoscale electronic devices more broadly, with potential applications extending into nanobioelectronics due to parylene's well-established biocompatible properties.

Orion Multi-Purpose Crew Vehicle Solving and Mitigating the Two Main Cluster Pendulum Problem

NASA Technical Reports Server (NTRS)

Ali, Yasmin; Sommer, Bruce; Troung, Tuan; Anderson, Brian; Madsen, Christopher

2017-01-01

The Orion Multi-purpose Crew Vehicle (MPCV) Orion spacecraft will return humans from beyond earth's orbit, including Mars and will be required to land 20,000 pounds of mass safely in the ocean. The parachute system nominally lands under 3 main parachutes, but the system is designed to be fault tolerant and land under 2 main parachutes. During several of the parachute development tests, it was observed that a pendulum, or swinging, motion could develop while the Crew Module (CM) was descending under two parachutes. This pendulum effect had not been previously predicted by modeling. Landing impact analysis showed that the landing loads would double in some places across the spacecraft. The CM structural design limits would be exceeded upon landing if this pendulum motion were to occur. The Orion descent and landing team was faced with potentially millions of dollars in structural modifications and a severe mass increase. A multidisciplinary team was formed to determine root cause, model the pendulum motion, study alternate canopy planforms and assess alternate operational vehicle controls & operations providing mitigation options resulting in a reliability level deemed safe for human spaceflight. The problem and solution is a balance of risk to a known solution versus a chance to improve the landing performance for the next human-rated spacecraft.

The environmental management problem of Pohorje, Slovenia: A new group approach within ANP - SWOT framework.

PubMed

Grošelj, Petra; Zadnik Stirn, Lidija

2015-09-15

Environmental management problems can be dealt with by combining participatory methods, which make it possible to include various stakeholders in a decision-making process, and multi-criteria methods, which offer a formal model for structuring and solving a problem. This paper proposes a three-phase decision making approach based on the analytic network process and SWOT (strengths, weaknesses, opportunities and threats) analysis. The approach enables inclusion of various stakeholders or groups of stakeholders in particular stages of decision making. The structure of the proposed approach is composed of a network consisting of an objective cluster, a cluster of strategic goals, a cluster of SWOT factors and a cluster of alternatives. The application of the suggested approach is applied to a management problem of Pohorje, a mountainous area in Slovenia. Stakeholders from sectors that are important for Pohorje (forestry, agriculture, tourism and nature protection agencies) who can offer a wide range of expert knowledge were included in the decision-making process. The results identify the alternative of "sustainable development" as the most appropriate for development of Pohorje. The application in the paper offers an example of employing the new approach to an environmental management problem. This can also be applied to decision-making problems in various other fields. Copyright © 2015 Elsevier Ltd. All rights reserved.

Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage.

PubMed

Beddoes, Charlotte M; Whitehouse, Michael R; Briscoe, Wuge H; Su, Bo

2016-06-03

Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are used. This results in undesirable side effects, including inadequate lubrication, wear debris, wear of the opposing articular cartilage, and weakening of the surrounding tissue. With the number of surgeries for cartilage repair increasing, a need for materials that can better mimic cartilage, and support the surrounding material in its typical function, is becoming evident. Here, we present a brief overview of the structure and properties of the hyaline cartilage and the current methods for cartilage repair. We then highlight some of the alternative materials under development as potential methods of repair; this is followed by an overview of the development of tough hydrogels. In particular, double network (DN) hydrogels are a promising replacement material, with continually improving physical properties. These hydrogels are coming closer to replicating the strength and toughness of the hyaline cartilage, while offering excellent lubrication. We conclude by highlighting several different methods of integrating replacement materials with the native joint to ensure stability and optimal behaviour.

Orthogonal Invariant Sets of the Diffusion Tensor and the Development of a Curvilinear Set Suitable for Low-Anisotropy Tissues

PubMed Central

Damion, Robin A.; Radjenovic, Aleksandra; Ingham, Eileen; Jin, Zhongmin; Ries, Michael E.

2013-01-01

We develop a curvilinear invariant set of the diffusion tensor which may be applied to Diffusion Tensor Imaging measurements on tissues and porous media. This new set is an alternative to the more common invariants such as fractional anisotropy and the diffusion mode. The alternative invariant set possesses a different structure to the other known invariant sets; the second and third members of the curvilinear set measure the degree of orthotropy and oblateness/prolateness, respectively. The proposed advantage of these invariants is that they may work well in situations of low diffusion anisotropy and isotropy, as is often observed in tissues such as cartilage. We also explore the other orthogonal invariant sets in terms of their geometry in relation to eigenvalue space; a cylindrical set, a spherical set (including fractional anisotropy and the mode), and a log-Euclidean set. These three sets have a common structure. The first invariant measures the magnitude of the diffusion, the second and third invariants capture aspects of the anisotropy; the magnitude of the anisotropy and the shape of the diffusion ellipsoid (the manner in which the anisotropy is realised). We also show a simple method to prove the orthogonality of the invariants within a set. PMID:24244366

School management and contingency theory: an emerging perspective.

PubMed

Hanson, E M

1979-01-01

In an article written for educational administrators, Hanson explains the assumptions, framework, and application of contingency theory. The author sees contingency theory as a way for organizations to adapt to uncertainty by developing a strategic plan with alternative scenarios. He urges school administrators to join businessmen and public managers in using a technique described as "the most powerful current sweeping over the organizational field." The theory assumes that: (1) a maze of goals govern the development of events; (2) different management approaches may be appropriate within the same organization; and (3) different leadership styles suit different situations. Contingency planning helps the organization to respond to uncertainty in the external environment by identifying possible events that may occur and by preparing alternative stratgies to deal with them. Hanson describes the purpose of this process as providing "a more effective match between an organization and its environment." He explains that contingency theory analyzes the internal adjustments of the organization (e.g., decision making process, structure, technology, instructional techniques) as it seeks to meet the shifting demands of its external or internal environments. According to the author, the intent of contingency theory is to establish an optimal "match" between environmental demands (and support) and the response capabilities of the organization including its structure, planning process, and leadership style.

Alternative Organisational Structures in Higher and Further Education. Coombe Lodge Working Paper. Information Bank Number 1471.

ERIC Educational Resources Information Center

Ferguson, C. T.

Alternative models of organizational structure are discussed in this paper as they operate in higher and further education in Great Britain. First, the basic principles of the traditional hierarchical model of college organization are presented, and the advantages and disadvantages of this model are highlighted. Next, the paper discusses the…

Discrete Structure-Point Testing: Problems and Alternatives. TESL Reporter, Vol. 9, No. 4.

ERIC Educational Resources Information Center

Aitken, Kenneth G.

This paper presents some reasons for reconsidering the use of discrete structure-point tests of language proficiency, and suggests an alternative basis for designing proficiency tests. Discrete point tests are one of the primary tools of the audio-lingual method of teaching a foreign language and are based on certain assumptions, including the…

Structural Validity of CLASS K-3 in Primary Grades: Testing Alternative Models

ERIC Educational Resources Information Center

Sandilos, Lia E.; Shervey, Sarah Wollersheim; DiPerna, James C.; Lei, Puiwa; Cheng, Weiyi

2017-01-01

This study examined the internal structure of the Classroom Assessment Scoring System (CLASS; K-3 version). The original CLASS K-3 model (Pianta, La Paro, & Hamre, 2008) and 5 alternative models were tested using confirmatory factor analysis with a sample of first- and second-grade classrooms (N = 141). Findings indicated that a slightly…

Effects of tree size and spatial distribution on growth of ponderosa pine forests under alternative management scenarios

Treesearch

C.W. Woodall; C.E. Fiedler; R.E. McRoberts

2009-01-01

Forest ecosystems may be actively managed toward heterogeneous stand structures to provide both economic (e.g., wood production and carbon credits) and environmental benefits (e.g., invasive pest resistance). In order to facilitate wider adoption of possibly more sustainable forest stand structures, defining growth expectations among alternative management scenarios is...

Laminated composite of magnetic alloy powder and ceramic powder and process for making same

DOEpatents

Moorhead, Arthur J.; Kim, Hyoun-Ee

1999-01-01

A laminated composite structure of alternating metal powder layers, and layers formed of an inorganic bonding media powder, and a method for manufacturing same are discosed. The method includes the steps of assembling in a cavity alternating layers of a metal powder and an inorganic bonding media of a ceramic, glass, and glass-ceramic. Heat, with or without pressure, is applied to the alternating layers until the particles of the metal powder are sintered together and bonded into the laminated composite structure by the layers of sintered inorganic bonding media to form a strong composite structure. The method finds particular application in the manufacture of high performance magnets wherein the metal powder is a magnetic alloy powder.

Laminated composite of magnetic alloy powder and ceramic powder and process for making same

DOEpatents

Moorhead, A.J.; Kim, H.

1999-08-10

A laminated composite structure of alternating metal powder layers, and layers formed of an inorganic bonding media powder, and a method for manufacturing same are disclosed. The method includes the steps of assembling in a cavity alternating layers of a metal powder and an inorganic bonding media of a ceramic, glass, and glass-ceramic. Heat, with or without pressure, is applied to the alternating layers until the particles of the metal powder are sintered together and bonded into the laminated composite structure by the layers of sintered inorganic bonding media to form a strong composite structure. The method finds particular application in the manufacture of high performance magnets wherein the metal powder is a magnetic alloy powder. 9 figs.

Effect of energy taxation on fuel choice and emissions (Energiaverojen vaikutus polttoainevalintoihin ja paeaestoeihin). Research notes (in English;Finnish)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leino, P.; Kosunen, P.; Rauhamaeki, J.

1997-05-01

The aim of the project was to study how various tax models for power plant fuels affect the fuel consumption and emissions of particles, sulphur dioxide (SO{sup 2}), nitrogen oxide (NOx) and carbon dioxide (CO{sup 2}). First, the development of Finnish energy taxation is discussed, followed by a survey of the energy production structure for 1994. For this purpose, it was necessary to prepare a large boiler database, which covers about 95% of the fuel consumption of Finnish energy production. The boiler database was used to calculate the emissions of particles, SO{sup 2}, NOx and CO{sup 2} in 1994. Themore » year 2010 selected under review is the year by which the Ministry of Trade and Industry has prepared their primary energy consumption estimates. Four different alternatives were studied as future tax models. In the first alternative taxation would be as it in years 1995--1996 and in the second alternative taxation would be as 1 January 1997. In the third alternative the Finnish application of EU taxes would be in force in full, i.e., the tax on heavy fuel oil would be 10 US dollars a barrel. In the fourth alternative there would be no taxes on fuels.« less

Support vector machine prediction of enzyme function with conjoint triad feature and hierarchical context.

PubMed

Wang, Yong-Cui; Wang, Yong; Yang, Zhi-Xia; Deng, Nai-Yang

2011-06-20

Enzymes are known as the largest class of proteins and their functions are usually annotated by the Enzyme Commission (EC), which uses a hierarchy structure, i.e., four numbers separated by periods, to classify the function of enzymes. Automatically categorizing enzyme into the EC hierarchy is crucial to understand its specific molecular mechanism. In this paper, we introduce two key improvements in predicting enzyme function within the machine learning framework. One is to introduce the efficient sequence encoding methods for representing given proteins. The second one is to develop a structure-based prediction method with low computational complexity. In particular, we propose to use the conjoint triad feature (CTF) to represent the given protein sequences by considering not only the composition of amino acids but also the neighbor relationships in the sequence. Then we develop a support vector machine (SVM)-based method, named as SVMHL (SVM for hierarchy labels), to output enzyme function by fully considering the hierarchical structure of EC. The experimental results show that our SVMHL with the CTF outperforms SVMHL with the amino acid composition (AAC) feature both in predictive accuracy and Matthew's correlation coefficient (MCC). In addition, SVMHL with the CTF obtains the accuracy and MCC ranging from 81% to 98% and 0.82 to 0.98 when predicting the first three EC digits on a low-homologous enzyme dataset. We further demonstrate that our method outperforms the methods which do not take account of hierarchical relationship among enzyme categories and alternative methods which incorporate prior knowledge about inter-class relationships. Our structure-based prediction model, SVMHL with the CTF, reduces the computational complexity and outperforms the alternative approaches in enzyme function prediction. Therefore our new method will be a useful tool for enzyme function prediction community.

Phenomenological investigation of despair in depression.

PubMed

Bürgy, Martin

2008-01-01

In current psychopathological literature, the concept of despair is almost redundant. At most, the term is applied in a behavioral biological context as a synonym for helplessness and hopelessness. In light of the fact that the subjective experience of despair is neglected, the present paper adopts a phenomenological approach. The selection and hermeneutic investigation of philosophical concepts serve as tools for an initial delineation of the core structure of despair. On the basis of a growing deviation between desire and reality, target and actual status, an alternating development is initiated which increasingly constricts and leads to hopelessness and suicide. This phenomenological core structure is identified from a number of integral characteristics of depression and further developed. Despair, thus, becomes a psychopathological key term through which access can be gained to the subjective experience of the depressive individual and which can provide the basis for promoting understanding and communication as well as developing successful therapeutic interventions.

Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism.

PubMed

Whicher, Jonathan R; MacKinnon, Roderick

2016-08-12

Voltage-gated potassium (K(v)) channels are gated by the movement of the transmembrane voltage sensor, which is coupled, through the helical S4-S5 linker, to the potassium pore. We determined the single-particle cryo-electron microscopy structure of mammalian K(v)10.1, or Eag1, bound to the channel inhibitor calmodulin, at 3.78 angstrom resolution. Unlike previous K(v) structures, the S4-S5 linker of Eag1 is a five-residue loop and the transmembrane segments are not domain swapped, which suggest an alternative mechanism of voltage-dependent gating. Additionally, the structure and position of the S4-S5 linker allow calmodulin to bind to the intracellular domains and to close the potassium pore, independent of voltage-sensor position. The structure reveals an alternative gating mechanism for K(v) channels and provides a template to further understand the gating properties of Eag1 and related channels. Copyright © 2016, American Association for the Advancement of Science.

Alternative Schools. Research Report 1976-3.

ERIC Educational Resources Information Center

National School Boards Association, Washington, DC.

During the 1970's, school districts throughout the country have created alternative educational programs allowing students and parents to choose the appropriate educational structure and methodology that suit their individual needs. School boards who establish alternative schools must assess, plan, design, effect, and evaluate educational programs…

Insect-inspired wing actuation structures based on ring-type resonators

NASA Astrophysics Data System (ADS)

Bolsman, Caspar T.; Goosen, Johannes F. L.; van Keulen, Fred

2008-03-01

In this paper, we illustrate and study the opportunities of resonant ring type structures as wing actuation mechanisms for a flapping wing Micro Air Vehicle (MAV). Various design alternatives are presented and studied based on computational and physical models. Insects provide an excellent source of inspiration for the development of the wing actuation mechanisms for flapping wing MAVs. The insect thorax is a structure which in essence provides a mechanism to couple the wing muscles to the wings while offering weight reduction through application of resonance, using tailored elasticity. The resonant properties of the thorax are a very effective way to reducing the power expenditure of wing movement. The wing movement itself is fairly complex and is guided by a set of control muscles and thoracic structures which are present in proximity of the wing root. The development of flapping wing MAVs requires a move away from classical structures and actuators. The use of gears and rotational electric motors is hard to justify at the small scale. Resonant structures provide a large design freedom whilst also providing various options for actuation. The move away from deterministic mechanisms offers possibilities for mass reduction.

Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers

PubMed Central

Zhang, Sichao; Chen, Yifang

2015-01-01

The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell’s Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings. PMID:26577813

From surprise to cognition: Some effects of the structure of C.A.L. simulation programs on the cognitive and scientific activities of young adults

NASA Astrophysics Data System (ADS)

Dicker, R. J.

The main objective of this thesis is to describe the effect on cognition of the structure of CAL simulation programs used, in science teaching. Four programs simulating a pond ecosystem were written so as to present a simulation model and to assist in cognition in different ways. Various clinically detailed methods of describing learning were developed and tried including concept maps which were found to be sammative rather than formative descriptions of learning, and to be ambiguous) and hierarchical structures (which were found to be difficult to produce). Fran these concept maps and hierarchical structures I developed my Interaction Model of Learning which can be used to describe the chronological events concerned with cognition. Using the Interaction Model, the nature of cognition and the effect that CAL program structure has on this process is described. Various scenarios are presented as a means of showing the possible effects of program structure on learning. Four forms of concept learning activity and their relationship to learning valid and alternative conceptions are described. The findings from the study are particularly related to the work of Driver (1983), Marton (1976) and Entwistle (1981).

Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers.

PubMed

Zhang, Sichao; Chen, Yifang

2015-11-18

The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell's Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings.

Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers

NASA Astrophysics Data System (ADS)

Zhang, Sichao; Chen, Yifang

2015-11-01

The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell’s Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings.

Structural basis for energy transduction by respiratory alternative complex III.

PubMed

Sousa, Joana S; Calisto, Filipa; Langer, Julian D; Mills, Deryck J; Refojo, Patrícia N; Teixeira, Miguel; Kühlbrandt, Werner; Vonck, Janet; Pereira, Manuela M

2018-04-30

Electron transfer in respiratory chains generates the electrochemical potential that serves as energy source for the cell. Prokaryotes can use a wide range of electron donors and acceptors and may have alternative complexes performing the same catalytic reactions as the mitochondrial complexes. This is the case for the alternative complex III (ACIII), a quinol:cytochrome c/HiPIP oxidoreductase. In order to understand the catalytic mechanism of this respiratory enzyme, we determined the structure of ACIII from Rhodothermus marinus at 3.9 Å resolution by single-particle cryo-electron microscopy. ACIII presents a so-far unique structure, for which we establish the arrangement of the cofactors (four iron-sulfur clusters and six c-type hemes) and propose the location of the quinol-binding site and the presence of two putative proton pathways in the membrane. Altogether, this structure provides insights into a mechanism for energy transduction and introduces ACIII as a redox-driven proton pump.

The structure of Zika virus NS5 reveals a conserved domain conformation

DOE PAGES

Wang, Boxiao; Tan, Xiao -Feng; Thurmond, Stephanie; ...

2017-03-27

The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alternative conformations of flavivirus NS5 proteins. In conclusion, the activity of this NS5 protein is verified through a de novo RdRp assay on a subgenomic ZIKV RNA template. Importantly, our structural analysis leads to the identification of a potential drug-binding site of ZIKV NS5, which might facilitate the development of novel antiviralsmore » for ZIKV.« less

Carbon source in the future chemical industries

NASA Astrophysics Data System (ADS)

Hofmann, Peter; Heinrich Krauch, Carl

1982-11-01

Rising crude oil prices favour the exploitation of hitherto unutilised energy carriers and the realisation of new technologies in all sectors where carbon is used. These changed economic constraints necessitate both savings in conventional petrochemistry and a change to oil-independent carbon sources in the chemical industry. While, in coal chemistry, the synthesis and process principles of petrochemistry — fragmentation of the raw material and subsequent buildup of molecular structures — can be maintained, the raw material structure largely remains unchanged in the chemistry of renewable raw materials. This lecture is to demonstrate the structural as well as the technological and energy criteria of the chemistry of alternative carbon sources, to forecast the chances of commercial realization and to discuss some promising fields of research and development.

Method for fabricating an ignitable heterogeneous stratified metal structure

DOEpatents

Barbee, T.W. Jr.; Weihs, T.

1996-08-20

A multilayer structure has a selectable: (1) propagating reaction front velocity V; (2) reaction initiation temperature attained by application of external energy; and (3) amount of energy delivered by a reaction of alternating unreacted layers of the multilayer structure. Because V is selectable and controllable, a variety of different applications for the multilayer structures are possible, including but not limited to their use as igniters, in joining applications, in fabrication of new materials, as smart materials and in medical applications and devices. The multilayer structure has a period D, and an energy release rate constant K. Two or more alternating unreacted layers are made of different materials and separated by reacted zones. The period D is equal to a sum of the widths of each single alternating reaction layer of a particular material, and also includes a sum of reacted zone widths, t{sub i}, in the period D. The multilayer structure has a selectable propagating reaction front velocity V, where V=K(1/D{sup n}){times}[1-(t{sub i}/D)] and n is about 0.8 to 1.2. 8 figs.

Method for fabricating an ignitable heterogeneous stratified metal structure

DOEpatents

Barbee, Jr., Troy W.; Weihs, Timothy

1996-01-01

A multilayer structure has a selectable, (i) propagating reaction front velocity V, (ii) reaction initiation temperature attained by application of external energy and (iii) amount of energy delivered by a reaction of alternating unreacted layers of the multilayer structure. Because V is selectable and controllable, a variety of different applications for the multilayer structures are possible, including but not limited to their use as ignitors, in joining applications, in fabrication of new materials, as smart materials and in medical applications and devices. The multilayer structure has a period D, and an energy release rate constant K. Two or more alternating unreacted layers are made of different materials and separated by reacted zones. The period D is equal to a sum of the widths of each single alternating reaction layer of a particular material, and also includes a sum of reacted zone widths, t.sub.i, in the period D. The multilayer structure has a selectable propagating reaction front velocity V, where V=K(1/D.sup.n).times.[1-(t.sub.i /D)]and n is about 0.8 to 1.2.

Structuration of lipid bases with fully hydrogenated crambe oil and sorbitan monostearate for obtaining zero-trans/low sat fats.

PubMed

Stahl, Marcella Aparecida; Buscato, Monise Helen Masuchi; Grimaldi, Renato; Cardoso, Lisandro Pavie; Ribeiro, Ana Paula Badan

2018-05-01

Several studies have shown that excessive intake of trans and saturated fatty acids is associated with an increased risk of cardiovascular disease. In this context, the food industry has sought alternatives for the development of healthy lipid bases, with higher levels of unsaturated fatty acids, adapting to current legislation. The incorporation of structuring agents into liquid oils has proven to be a potential alternative for obtaining semi-plastic lipid bases with reduced levels of saturated fatty acids. Thus, the objective of this study was to produce zero trans fat bases with lower saturated fatty acids levels. Palm oil (PO) was used as a zero trans-lipid base reference because of its technological functionality. Blends containing different proportions of high oleic sunflower oil (HOSO) and PO were prepared as follows: control 100: 0; 80:20; 60:40; 40:60; 20:80; and 100: 0 PO: HOSO (w/w%), respectively. Then, 3% of fully hydrogenated crambe oil (FHCO) and 3% sorbitan monostearate (SMS) were added to the blends as structuring agents, forming the structured (S) blends. The addition of HOSO to the PO decreased the saturated fatty acids by up to 30.6%, with consequent increase of unsaturated fatty acids, especially oleic acid. The joint action of the SMS and the FCHO allowed for obtaining structured blends with plastic and spreadability characteristics, as well as modifications throughout the crystallization process of the original blends. Copyright © 2018 Elsevier Ltd. All rights reserved.

Edible oil structuring: an overview and recent updates.

PubMed

Patel, Ashok R; Dewettinck, Koen

2016-01-01

In recent years, research dealing with edible oil structuring has received considerable interest from scientific community working in the area of food formulation. Much of this interest is linked to the possibility of using structured oil in development of newer product formats with improved nutritional profile (trans fat-free, low in saturated fats and high in mono and/or poly unsaturated fatty acids). In addition to the obvious industrial need of finding the alternative formulation approach, the interesting properties of structured systems (particularly, oleogels) also makes them a fascinating subject for fundamental studies. In this paper, we attempt to give a comprehensive and concise overview of the field of oil structuring with special emphasis on the updates from recent years. Specifically, several categories of food-grade oleogelators and their potential food applications are summarized with typical examples along with a discussion on the general principles and unresolved challenges related to this emerging area.

Multilayer porous structures of HVPE and MOCVD grown GaN for photonic applications

NASA Astrophysics Data System (ADS)

Braniste, T.; Ciers, Joachim; Monaico, Ed.; Martin, D.; Carlin, J.-F.; Ursaki, V. V.; Sergentu, V. V.; Tiginyanu, I. M.; Grandjean, N.

2017-02-01

In this paper we report on a comparative study of electrochemical processes for the preparation of multilayer porous structures in hydride vapor phase epitaxy (HVPE) and metal organic chemical vapor phase deposition (MOCVD) grown GaN. It was found that in HVPE-grown GaN, multilayer porous structures are obtained due to self-organization processes leading to a fine modulation of doping during the crystal growth. However, these processes are not totally under control. Multilayer porous structures with a controlled design have been produced by optimizing the technological process of electrochemical etching in MOCVD-grown samples, consisting of five pairs of thin layers with alternating-doping profiles. The samples have been characterized by SEM imaging, photoluminescence spectroscopy, and micro-reflectivity measurements, accompanied by transfer matrix analysis and simulations by a method developed for the calculation of optical reflection spectra. We demonstrate the applicability of the produced structures for the design of Bragg reflectors.

Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes.

PubMed

Cer, Regina Z; Bruce, Kevin H; Mudunuri, Uma S; Yi, Ming; Volfovsky, Natalia; Luke, Brian T; Bacolla, Albino; Collins, Jack R; Stephens, Robert M

2011-01-01

Although the capability of DNA to form a variety of non-canonical (non-B) structures has long been recognized, the overall significance of these alternate conformations in biology has only recently become accepted en masse. In order to provide access to genome-wide locations of these classes of predicted structures, we have developed non-B DB, a database integrating annotations and analysis of non-B DNA-forming sequence motifs. The database provides the most complete list of alternative DNA structure predictions available, including Z-DNA motifs, quadruplex-forming motifs, inverted repeats, mirror repeats and direct repeats and their associated subsets of cruciforms, triplex and slipped structures, respectively. The database also contains motifs predicted to form static DNA bends, short tandem repeats and homo(purine•pyrimidine) tracts that have been associated with disease. The database has been built using the latest releases of the human, chimp, dog, macaque and mouse genomes, so that the results can be compared directly with other data sources. In order to make the data interpretable in a genomic context, features such as genes, single-nucleotide polymorphisms and repetitive elements (SINE, LINE, etc.) have also been incorporated. The database is accessed through query pages that produce results with links to the UCSC browser and a GBrowse-based genomic viewer. It is freely accessible at http://nonb.abcc.ncifcrf.gov.

TRANSAT-- method for detecting the conserved helices of functional RNA structures, including transient, pseudo-knotted and alternative structures.

PubMed

Wiebe, Nicholas J P; Meyer, Irmtraud M

2010-06-24

The prediction of functional RNA structures has attracted increased interest, as it allows us to study the potential functional roles of many genes. RNA structure prediction methods, however, assume that there is a unique functional RNA structure and also do not predict functional features required for in vivo folding. In order to understand how functional RNA structures form in vivo, we require sophisticated experiments or reliable prediction methods. So far, there exist only a few, experimentally validated transient RNA structures. On the computational side, there exist several computer programs which aim to predict the co-transcriptional folding pathway in vivo, but these make a range of simplifying assumptions and do not capture all features known to influence RNA folding in vivo. We want to investigate if evolutionarily related RNA genes fold in a similar way in vivo. To this end, we have developed a new computational method, Transat, which detects conserved helices of high statistical significance. We introduce the method, present a comprehensive performance evaluation and show that Transat is able to predict the structural features of known reference structures including pseudo-knotted ones as well as those of known alternative structural configurations. Transat can also identify unstructured sub-sequences bound by other molecules and provides evidence for new helices which may define folding pathways, supporting the notion that homologous RNA sequence not only assume a similar reference RNA structure, but also fold similarly. Finally, we show that the structural features predicted by Transat differ from those assuming thermodynamic equilibrium. Unlike the existing methods for predicting folding pathways, our method works in a comparative way. This has the disadvantage of not being able to predict features as function of time, but has the considerable advantage of highlighting conserved features and of not requiring a detailed knowledge of the cellular environment.

A rationally designed composite of alternating strata of Si nanoparticles and graphene: a high-performance lithium-ion battery anode.

PubMed

Sun, Fu; Huang, Kai; Qi, Xiang; Gao, Tian; Liu, Yuping; Zou, Xianghua; Wei, Xiaolin; Zhong, Jianxin

2013-09-21

We have successfully fabricated a free-standing Si-re-G (reduced graphene) alternating stratum structure composite through a repeated process of filtering liquid exfoliated graphene oxide and uniformly dispersed Si solution, followed by the reduction of graphene oxide. The as-prepared free-standing flexible alternating stratum structure composite was directly evaluated as the anode for rechargeable lithium half-cells without adding any polymer binder, conductive additives or using current collectors. The half cells based on this new alternating structure composite exhibit an unexpected capacity of 1500 mA h g(-1) after 100 cycles at 1.35 A g(-1). Our rationally proposed strategy has incorporated the long cycle life of carbon and the high lithium-storage capacity of Si into one entity using the feasible and scalable vacuum filtration technique, rendering this new protocol as a readily applicable means of addressing the practical application challenges associated with the next generation of rechargeable lithium-ion batteries.

Loop-driven conformational transition between the alternative and collapsed form of prethrombin-2: targeted molecular dynamics study.

PubMed

Wu, Sangwook

2017-01-01

Two distinct crystal structures of prethrombin-2, the alternative and collapsed forms, are elucidated by X-ray crystallogrphy. We analyzed the conformational transition from the alternative to the collapsed form employing targeted molecular dynamics (TMD) simulation. Despite small RMSD difference in the two X-ray crystal structures, some hydrophobic residues (W60d, W148, W215, and F227) show a significant difference between the two conformations. TMD simulation shows that the four hydrophobic residues undergo concerted movement from dimer to trimer transition via tetramer state in the conformational change from the alternative to the collapsed form. We reveal that the concerted movement of the four hydrophobic residues is controlled by movement of specific loop regions behind. In this paper, we propose a sequential scenario for the conformational transition from the alternative form to the collapsed form, which is partially supported by the mutant W148A simulation.

Structural Properties of Single-Strand Orthodontic Wires from a Proposed Alternative Standard Flexure Test.

DTIC Science & Technology

1984-01-01

structural system the orthodontic appliance consists intraorally of bands or bonded pads and the attached brackets , the arch wires, the ligatures, and any...RD-Ali5B 994 STRUCTURAL PROPERTIES OF SINGLE-STRAND ORTHODONTIC i/i WIRES FROM A PROPOSED__(U) AIR FORCE INST OF TECH WRIGHT-PATTERSON RFB OH M L... Orthodontic Wires From A Proposed Alternative - Standard Flexure Test 6. PERPOMING o1. REPORT NUMBER AUTNOR(e) I. CONTRACT O& GRANT NUMUER(a) Marion L

Engineered Structured Sorbents for the Adsorption of Carbon Dioxide and Water Vapor from Manned Spacecraft Atmospheres: Applications and Testing 2008/2009

NASA Technical Reports Server (NTRS)

Howard, David F.; Perry, Jay L.; Knox, James C.; Junaedi, Christian

2009-01-01

This paper describes efforts to improve on typical packed beds of sorbent pellets by making use of structured sorbents and alternate bed configurations to improve system efficiency and reliability. The benefits of the alternate configurations include increased structural stability gained by eliminating clay bound zeolite pellets that tend to fluidize and erode, and better thermal control during sorption to increase process efficiency. Test results that demonstrate such improvements are described and presented.

Alternative energy balances for Bulgaria to mitigate climate change

NASA Astrophysics Data System (ADS)

Christov, Christo

1996-01-01

Alternative energy balances aimed to mitigate greenhouse gas (GHG) emissions are developed as alternatives to the baseline energy balance. The section of mitigation options is based on the results of the GHG emission inventory for the 1987 1992 period. The energy sector is the main contributor to the total CO2 emissions of Bulgaria. Stationary combustion for heat and electricity production as well as direct end-use combustion amounts to 80% of the total emissions. The parts of the energy network that could have the biggest influence on GHG emission reduction are identified. The potential effects of the following mitigation measures are discussed: rehabilitation of the combustion facilities currently in operation; repowering to natural gas; reduction of losses in thermal and electrical transmission and distribution networks; penetration of new combustion technologies; tariff structure improvement; renewable sources for electricity and heat production; wasteheat utilization; and supply of households with natural gas to substitute for electricity in space heating and cooking. The total available and the achievable potentials are estimated and the implementation barriers are discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Webb, Ian K.; Garimella, Sandilya V. B.; Tolmachev, Aleksey V.

A Structures for Lossless Ion Manipulations (SLIM) module that allows ion mobility separations and the switching of ions between alternative drift paths is described. The SLIM switch component has a “Tee” configuration and allows switching of ions between a linear path and a 90-degree bend. By controlling switching times, ions can be deflected to an alternative channel as a function of their mobilities. In the initial evaluation the switch is used in a static mode and shown compatible with high performance ion mobility separations at 4 torr. In the “dynamic mode” we show that mobility-selected ions can be switched intomore » the alternative channel, and that various ion species can be independently selected based on their mobilities for time-of-flight mass spectrometer (TOF MS) IMS detection and mass analysis. Ultimately, this development also provides the basis for e.g. the selection of specific mobilities for storage and accumulation, and key modules for the assembly of SLIM devices enabling much more complex sequences of ion manipulations.« less

Everyday ethical problems in dementia care: a teleological model.

PubMed

Bolmsjö, Ingrid Agren; Edberg, Anna-Karin; Sandman, Lars

2006-07-01

In this article, a teleological model for analysis of everyday ethical situations in dementia care is used to analyse and clarify perennial ethical problems in nursing home care for persons with dementia. This is done with the aim of describing how such a model could be useful in a concrete care context. The model was developed by Sandman and is based on four aspects: the goal; ethical side-constraints to what can be done to realize such a goal; structural constraints; and nurses' ethical competency. The model contains the following main steps: identifying and describing the normative situation; identifying and describing the different possible alternatives; assessing and evaluating the different alternatives; and deciding on, implementing and evaluating the chosen alternative. Three ethically difficult situations from dementia care were used for the application of the model. The model proved useful for the analysis of nurses' everyday ethical dilemmas and will be further explored to evaluate how well it can serve as a tool to identify and handle problems that arise in nursing care.

Identifying selectively important amino acid positions associated with alternative habitat environments in fish mitochondrial genomes.

PubMed

Xia, Jun Hong; Li, Hong Lian; Zhang, Yong; Meng, Zi Ning; Lin, Hao Ran

2018-05-01

Fish species inhabitating seawater (SW) or freshwater (FW) habitats have to develop genetic adaptations to alternative environment factors, especially salinity. Functional consequences of the protein variations associated with habitat environments in fish mitochondrial genomes have not yet received much attention. We analyzed 829 complete fish mitochondrial genomes and compared the amino acid differences of 13 mitochondrial protein families between FW and SW fish groups. We identified 47 specificity determining sites (SDS) that associated with FW or SW environments from 12 mitochondrial protein families. Thirty-two (68%) of the SDS sites are hydrophobic, 13 (28%) are neutral, and the remaining sites are acidic or basic. Seven of those SDS from ND1, ND2 and ND5 were scored as probably damaging to the protein structures. Furthermore, phylogenetic tree based Bayes Empirical Bayes analysis also detected 63 positive sites associated with alternative habitat environments across ten mtDNA proteins. These signatures could be important for studying mitochondrial genetic variation relevant to fish physiology and ecology.

Arrangement of Proteinogenic α-Amino Acids on a Cyclic Peptide Comprising Alternate Biphenyl-Cored ζ-Amino Acids.

PubMed

Tashiro, Shohei; Chiba, Masayuki; Shionoya, Mitsuhiko

2017-05-18

Aiming at precisely arranging several proteinogenic α-amino acids on a folded scaffold, we have developed a cyclic hexapeptide comprising an alternate sequence of biphenyl-cored ζ-amino acids and proteinogenic α-amino acids such as l-leucine. The amino acids were connected by typical peptide synthesis, and the resultant linear hexapeptide was intramolecularly cyclized to form a target cyclic peptide. Theoretical analyses and NMR spectroscopy suggested that the cyclic peptide was folded into an unsymmetrical conformation, and the structure was likely to be flexible in CHCl 3 . The optical properties including UV/Vis absorption, fluorescence, and circular dichroism (CD) were also evaluated. Furthermore, the cyclic peptide became soluble in water by introducing three carboxylate groups at the periphery of the cyclic skeleton. This α/ζ-alternating cyclic peptide is therefore expected to serve as a unique scaffold for arranging several functionalities. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Demonstration of the Application of Composite Load Spectra (CLS) and Probabilistic Structural Analysis (PSAM) Codes to SSME Heat Exchanger Turnaround Vane

NASA Technical Reports Server (NTRS)

Rajagopal, Kadambi R.; DebChaudhury, Amitabha; Orient, George

2000-01-01

This report describes a probabilistic structural analysis performed to determine the probabilistic structural response under fluctuating random pressure loads for the Space Shuttle Main Engine (SSME) turnaround vane. It uses a newly developed frequency and distance dependent correlation model that has features to model the decay phenomena along the flow and across the flow with the capability to introduce a phase delay. The analytical results are compared using two computer codes SAFER (Spectral Analysis of Finite Element Responses) and NESSUS (Numerical Evaluation of Stochastic Structures Under Stress) and with experimentally observed strain gage data. The computer code NESSUS with an interface to a sub set of Composite Load Spectra (CLS) code is used for the probabilistic analysis. A Fatigue code was used to calculate fatigue damage due to the random pressure excitation. The random variables modeled include engine system primitive variables that influence the operating conditions, convection velocity coefficient, stress concentration factor, structural damping, and thickness of the inner and outer vanes. The need for an appropriate correlation model in addition to magnitude of the PSD is emphasized. The study demonstrates that correlation characteristics even under random pressure loads are capable of causing resonance like effects for some modes. The study identifies the important variables that contribute to structural alternate stress response and drive the fatigue damage for the new design. Since the alternate stress for the new redesign is less than the endurance limit for the material, the damage due high cycle fatigue is negligible.

Ruthenium (Ru) peeling and predicting robustness of the capping layer using finite element method (FEM) modeling

NASA Astrophysics Data System (ADS)

Jang, Il-Yong; John, Arun; Goodwin, Frank; Lee, Su-Young; Kim, Byung-Gook; Kim, Seong-Sue; Jeon, Chan-Uk; Kim, Jae Hyung; Jang, Yong Hoon

2014-07-01

Ruthenium (Ru) film used as capping layer in extreme ultraviolet (EUV) mask peeled off after annealing and in-situ UV (IUV) cleaning. We investigated Ru peeling and found out that the mechanical stress caused by the formation of Si oxide due to the penetration of oxygen atoms from ambient or cleaning media to top-Si of ML is the root cause for the problem. To support our experimental results, we developed a numerical model of finite element method (FEM) using commercial software (ABAQUS™) to calculate the stress and displacement forced on the capping layer. By using this model, we could observe that the displacement agrees well with the actual results measured from the transmission electron microscopy (TEM) image. Using the ion beam deposition (IBD) tool at SEMATECH, we developed four new types of alternative capping materials (RuA, RuB, B4C, B4C-buffered Ru). The durability of each new alternative capping layer observed by experiment was better than that of conventional Ru. The stress and displacement calculated from each new alternative capping layer, using modeling, also agreed well with the experimental results. A new EUV mask structure is proposed, inserting a layer of B4C (B4C-buffered Ru) at the interface between the capping layer (Ru) and the top-Si layer. The modeling results showed that the maximum displacement and bending stress observed from the B4C-buffered Ru are significantly lower than that of single capping layer cases. The durability investigated from the experiment also showed that the B4C-buffered structure is at least 3X stronger than that of conventional Ru.

Biomedical microfluidic devices by using low-cost fabrication techniques: A review.

PubMed

Faustino, Vera; Catarino, Susana O; Lima, Rui; Minas, Graça

2016-07-26

One of the most popular methods to fabricate biomedical microfluidic devices is by using a soft-lithography technique. However, the fabrication of the moulds to produce microfluidic devices, such as SU-8 moulds, usually requires a cleanroom environment that can be quite costly. Therefore, many efforts have been made to develop low-cost alternatives for the fabrication of microstructures, avoiding the use of cleanroom facilities. Recently, low-cost techniques without cleanroom facilities that feature aspect ratios more than 20, for fabricating those SU-8 moulds have been gaining popularity among biomedical research community. In those techniques, Ultraviolet (UV) exposure equipment, commonly used in the Printed Circuit Board (PCB) industry, replaces the more expensive and less available Mask Aligner that has been used in the last 15 years for SU-8 patterning. Alternatively, non-lithographic low-cost techniques, due to their ability for large-scale production, have increased the interest of the industrial and research community to develop simple, rapid and low-cost microfluidic structures. These alternative techniques include Print and Peel methods (PAP), laserjet, solid ink, cutting plotters or micromilling, that use equipment available in almost all laboratories and offices. An example is the xurography technique that uses a cutting plotter machine and adhesive vinyl films to generate the master moulds to fabricate microfluidic channels. In this review, we present a selection of the most recent lithographic and non-lithographic low-cost techniques to fabricate microfluidic structures, focused on the features and limitations of each technique. Only microfabrication methods that do not require the use of cleanrooms are considered. Additionally, potential applications of these microfluidic devices in biomedical engineering are presented with some illustrative examples. Copyright © 2015 Elsevier Ltd. All rights reserved.

Impact of parity on ewe vaginal mechanical properties relative to the nonhuman primate and rodent

PubMed Central

Knight, Katrina M.; Moalli, Pamela A.; Nolfi, Alexis; Palcsey, Stacy; Barone, William R.

2016-01-01

Introduction and hypothesis Parity is the leading risk factor for the development of pelvic organ prolapse. To assess the impact of pregnancy and delivery on vaginal tissue, researchers commonly use nonhuman primate (NHP) and rodent models. The purpose of this study was to evaluate the ewe as an alternative model by investigating the impact of parity on the ewe vaginal mechanical properties and collagen structure. Methods Mechanical properties of 15 nulliparous and parous ewe vaginas were determined via uniaxial tensile tests. Collagen content was determined by hydroxyproline assay and collagen fiber thickness was analyzed using picrosirius red staining. Outcome measures were compared using Independent samples t or Mann–Whitney U tests. ANOVA (Gabriel’s pairwise post-hoc test) or the Welch Alternative for the F-ratio (Games Howell post-hoc test) was used to compare data with previously published NHP and rodent data. Results Vaginal tissue from the nulliparous ewe had a higher tangent modulus and tensile strength compared with the parous ewe (p < 0.025). The parous ewe vagina elongated 42 % more than the nulliparous ewe vagina (p = 0.015). No significant differences were observed in collagen structure among ewe vaginas. The tangent modulus of the nulliparous ewe vagina was not different from that of the NHP or rodent (p = 0.290). Additionally, the tangent moduli of the parous ewe and NHP vaginas did not differ (p = 0.773). Conclusions Parity has a negative impact on the mechanical properties of the ewe vagina, as also observed in the NHP. The ewe may serve as an alternative model for studying parity and ultimately prolapse development. PMID:26872644

24 CFR 3288.110 - Alternative Process agreements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Alternative Process agreements... HOUSING AND URBAN DEVELOPMENT MANUFACTURED HOME DISPUTE RESOLUTION PROGRAM Alternative Process in HUD-Administered States § 3288.110 Alternative Process agreements. (a) Required agreement. To use the Alternative...

Structure of 2,4-Diaminopyrimidine - Theobromine Alternate Base Pairs

NASA Technical Reports Server (NTRS)

Gengeliczki, Zsolt; Callahan, Michael P.; Kabelac, Martin; Rijs, Anouk M.; deVries, Mattanjah S.

2011-01-01

We report the structure of clusters of 2,4-diaminopyrimidine with 3,7-dimethylxanthine (theobromine) in the gas phase determined by IR-UV double resonance spectroscopy in both the near-IR and mid-IR regions in combination with ab initio computations. These clusters represent potential alternate nucleobase pairs, geometrically equivalent to guanine-cytosine. We have found the four lowest energy structures, which include the Watson-Crick base pairing motif. This Watson-Crick structure has not been observed by resonant two-photon ionization (R2PI) in the gas phase for the canonical DNA base pairs.

Model-assisted development of a laminography inspection system

NASA Astrophysics Data System (ADS)

Grandin, R.; Gray, J.

2012-05-01

Traditional computed tomography (CT) is an effective method of determining the internal structure of an object through non-destructive means; however, inspection of certain objects, such as those with planar geometrics or with limited access, requires an alternate approach. An alternative is laminography and has been the focus of a number of researchers in the past decade for both medical and industrial inspections. Many research efforts rely on geometrically-simple analytical models, such as the Shepp-Logan phantom, for the development of their algorithms. Recent work at the Center for Non-Destructive Evaluation makes extensive use of a forward model, XRSIM, to study artifacts arising from the reconstruction method, the effects of complex geometries and known issues such as high density features on the laminography reconstruction process. The use of a model provides full knowledge of all aspects of the geometry and provides a means to quantitatively evaluate the impact of methods designed to reduce artifacts generated by the reconstruction methods or that are result of the part geometry. We will illustrate the use of forward simulations to quantitatively assess reconstruction algorithm development and artifact reduction.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tessore, Nicolas; Metcalf, R. Benton; Winther, Hans A.

A number of alternatives to general relativity exhibit gravitational screening in the non-linear regime of structure formation. We describe a set of algorithms that can produce weak lensing maps of large scale structure in such theories and can be used to generate mock surveys for cosmological analysis. By analysing a few basic statistics we indicate how these alternatives can be distinguished from general relativity with future weak lensing surveys.

The Construct Validity of Scores on the Ways of Coping Questionnaire: Confirmatory Analysis of Alternative Factor Structures.

ERIC Educational Resources Information Center

Edwards, Jeffrey R.; O'Neill, Regina M.

1998-01-01

Confirmatory factor analysis was used to evaluate alternative factor structures, based on previous exploratory factor analyses and coping dimensions derived from the theory of R. Lazarus, for the Ways of Coping Questionnaire (S. Folkman and R. Lazarus, 1988). Results from responses of 654 college graduates provide little support for the factor…

76 FR 58138 - Defense Federal Acquisition Regulation Supplement (DFARS); Alternative Line Item Structure (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... DoD published a proposed rule in the Federal Register at 76 FR 21847 on April 19, 2011, to add DFARS..., the contract line item may be for a desktop computer, but the actual items delivered, invoiced, and..., Desktop with 20 EA CPU, Monitor, Keyboard and Mouse. Alternative line-item structure offer where monitors...

Representation of Knowledge

DTIC Science & Technology

1980-03-01

structure composed of nodes representing semantic primitives. From this structure, a French translation of the input is generated. The translation serves as a...Style: range: (Burgers, Chinese, American, Seafood, French ) default: American if-added: (Update Alternatives of Restaurant) Times-of-Operation: range: a...Restaurant Frame is used to modify the list of alternative restaurants once a particular cuisine is chosen. In some systems, trigger procedures

Monolithic Interconnected Modules (MIMs) for Thermophotovoltaic Energy Conversion

NASA Technical Reports Server (NTRS)

Wilt, David; Wehrer, Rebecca; Palmisiano, Marc; Wanlass, Mark; Murray, Christopher

2003-01-01

Monolithic Interconnected Modules (MIM) are under development for thermophotovoltaic (TPV) energy conversion applications. MIM devices are typified by series-interconnected photovoltaic cells on a common, semi-insulating substrate and generally include rear-surface infrared (IR) reflectors. The MIM architecture is being implemented in InGaAsSb materials without semi-insulating substrates through the development of alternative isolation methodologies. Motivations for developing the MIM structure include: reduced resistive losses, higher output power density than for systems utilizing front surface spectral control, improved thermal coupling and ultimately higher system efficiency. Numerous design and material changes have been investigated since the introduction of the MIM concept in 1994. These developments as well as the current design strategies are addressed.

Combinatorial vector fields and the valley structure of fitness landscapes.

PubMed

Stadler, Bärbel M R; Stadler, Peter F

2010-12-01

Adaptive (downhill) walks are a computationally convenient way of analyzing the geometric structure of fitness landscapes. Their inherently stochastic nature has limited their mathematical analysis, however. Here we develop a framework that interprets adaptive walks as deterministic trajectories in combinatorial vector fields and in return associate these combinatorial vector fields with weights that measure their steepness across the landscape. We show that the combinatorial vector fields and their weights have a product structure that is governed by the neutrality of the landscape. This product structure makes practical computations feasible. The framework presented here also provides an alternative, and mathematically more convenient, way of defining notions of valleys, saddle points, and barriers in landscape. As an application, we propose a refined approximation for transition rates between macrostates that are associated with the valleys of the landscape.

Comparative Proteomics Reveals a Significant Bias Toward Alternative Protein Isoforms with Conserved Structure and Function

PubMed Central

Ezkurdia, Iakes; del Pozo, Angela; Frankish, Adam; Rodriguez, Jose Manuel; Harrow, Jennifer; Ashman, Keith; Valencia, Alfonso; Tress, Michael L.

2012-01-01

Advances in high-throughput mass spectrometry are making proteomics an increasingly important tool in genome annotation projects. Peptides detected in mass spectrometry experiments can be used to validate gene models and verify the translation of putative coding sequences (CDSs). Here, we have identified peptides that cover 35% of the genes annotated by the GENCODE consortium for the human genome as part of a comprehensive analysis of experimental spectra from two large publicly available mass spectrometry databases. We detected the translation to protein of “novel” and “putative” protein-coding transcripts as well as transcripts annotated as pseudogenes and nonsense-mediated decay targets. We provide a detailed overview of the population of alternatively spliced protein isoforms that are detectable by peptide identification methods. We found that 150 genes expressed multiple alternative protein isoforms. This constitutes the largest set of reliably confirmed alternatively spliced proteins yet discovered. Three groups of genes were highly overrepresented. We detected alternative isoforms for 10 of the 25 possible heterogeneous nuclear ribonucleoproteins, proteins with a key role in the splicing process. Alternative isoforms generated from interchangeable homologous exons and from short indels were also significantly enriched, both in human experiments and in parallel analyses of mouse and Drosophila proteomics experiments. Our results show that a surprisingly high proportion (almost 25%) of the detected alternative isoforms are only subtly different from their constitutive counterparts. Many of the alternative splicing events that give rise to these alternative isoforms are conserved in mouse. It was striking that very few of these conserved splicing events broke Pfam functional domains or would damage globular protein structures. This evidence of a strong bias toward subtle differences in CDS and likely conserved cellular function and structure is remarkable and strongly suggests that the translation of alternative transcripts may be subject to selective constraints. PMID:22446687

Synthetic Biological Approaches to Natural Product Biosynthesis

PubMed Central

Winter, Jaclyn M; Tang, Yi

2012-01-01

Small molecules produced in Nature continue to be an inspiration for the development of new therapeutic agents. These natural products possess exquisite chemical diversity, which gives rise to their wide range of biological activities. In their host organism, natural products are assembled and modified by dedicated biosynthetic pathways that Nature has meticulously developed. Often times, the complex structures or chemical modifications instated by these pathways are difficult to replicate using traditional synthetic methods. An alternative approach for creating or enhancing the structural variation of natural products is through combinatorial biosynthesis. By rationally reprogramming and manipulating the biosynthetic machinery responsible for their production, unnatural metabolites that were otherwise inaccessible can be obtained. Additionally, new chemical structures can be synthesized or derivatized by developing the enzymes that carry out these complicated chemical reactions into biocatalysts. In this review, we will discuss a variety of combinatorial biosynthetic strategies, their technical challenges, and highlight some recent (since 2007) examples of rationally designed unnatural metabolites, as well as platforms that have been established for the production and modification of clinically important pharmaceutical compounds. PMID:22221832

Development of Interlocking Masonry Bricks and its’ Structural Behaviour: A Review Paper

NASA Astrophysics Data System (ADS)

Al-Fakih, Amin; Mohammed, Bashar S.; Nuruddin, Fadhil; Nikbakht, Ehsan

2018-04-01

Conventional bricks are the most elementary building materials for houses construction. However, the rapid growth in today’s construction industry has obliged the civil engineers in searching for a new building technique that may result in even greater economy, more efficient and durable as an alternative for the conventional brick. Moreover, the high demands for having a speedy and less labour and cost building systems is one of the factor that cause the changes of the masonry conventional systems. These changes have led to improved constructability, performance, and cost as well. Several interlocking bricks has been developed and implemented in building constructions and a number of researches had studied the manufacturing of interlocking brick and its structural behaviour as load bearing and non-load bearing element. This technical paper aims to review the development of interlocking brick and its structural behaviour. In conclusion, the concept of interlocking system has been widely used as a replacement of the conventional system where it has been utilized either as load bearing or non-load bearing masonry system.

Live celloidosome structures based on the assembly of individual cells by colloid interactions.

PubMed

Fakhrullin, Rawil F; Brandy, Marie-Laure; Cayre, Olivier J; Velev, Orlin D; Paunov, Vesselin N

2010-10-14

A new class of colloid structures, celloidosomes, has been developed which represent hollow microcapsules whose membranes consist of a single monolayer of living cells. Two routes for producing these structures were designed based on templating of: (i) air bubbles and (ii) anisotropic microcrystals of calcium carbonate with living cells, which allowed us to fabricate celloidosomes of spherical, rhombohedral and needle-like morphologies. Air microbubbles were templated by yeast cells coated with poly(allylamine hydrochloride) (PAH), then coated with carboxymethylcellulose and rehydrated resulting in the formation of spherical multicellular structures. Similarly, calcium carbonate microcrystals of anisotropic shapes were coated with several consecutive layers of oppositely charged polyelectrolytes to obtain a positive surface charge which was used to immobilise yeast cells coated with anionic polyelectrolyte of their surfaces. After dissolving of sacrificial cores, hollow multicellular structures were obtained. The viability of the cells in the produced structures was confirmed by using fluorescein diacetate. In order to optimize the separation of celloidosomes from free cells magnetic nanoparticles were immobilised onto the surface of templates prior to the cells deposition, which greatly facilitated the separation using a permanent magnet. Two alternative approaches were developed to form celloidosome structures using magnetically functionalised core-shell microparticles which resulted in the formation of celloidosomes with needle-like and cubic-like geometries which follows the original morphology of the calcium carbonate microcrystals. Our methods for fabrication of celloidosomes may found applications in the development of novel symbiotic bio-structures, artificial multicellular organisms and in tissue engineering. The unusual structure of celloidosomes resembles the primitive forms of multicellular species, like Volvox, and other algae and could be regarded as one possible mechanism of the evolutionary development of multicellularity.

Developing alternative over-the-counter medicine label formats: How do they compare when evaluated by consumers?

PubMed

Tong, Vivien; Raynor, David K; Aslani, Parisa

2018-03-01

In recent years, the Australian Therapeutic Goods Administration (TGA) has proposed implementing a standardized over-the-counter (OTC) medicine label. However, there were mixed consumer opinions regarding a label proposed in 2012 and limited evidence demonstrating the usability of the revised (2014) format. To develop and examine the usability of alternative OTC medicine label formats for standardization, and explore consumer perspectives on the labels. Four alternative labels were developed for the exemplar medicine diclofenac. One was based on the Medicine Information label proposed by the TGA ('Medicine Information'), one was based on the U.S. Drug Facts label ('Drug Facts'), and two were based on suggestions proposed by consumers in the earlier needs analysis phase of this research (referred to as the 'Medicine Facts' and 'Consumer Desires' label formats). Five cohorts of 10 participants were recruited. Each cohort was assigned to user test one of the alternative labels or an existing label for a proprietary diclofenac product (which acted as a comparator) for diagnostic purposes. Each participant then provided feedback on all 5 labels. Each interview consisted of the administration of a user testing questionnaire, measuring consumers' ability to find and understand key points of information, and a semi-structured interview exploring consumer perspectives. Overall, all 4 alternative label formats supported consumers' ability to find and understand key points. The existing comparator label was the poorer label with respect to participants' ability to find and understand key points. Factors such as perceived usability, color, design, content, and/or content ordering impacted consumer preferences. The 'Consumer Desires' or 'Drug Facts' label formats were most often preferred by consumers for use as the standardized OTC label over the TGA proposed format. All alternative label formats demonstrated satisfactory usability and could be considered for use in OTC label standardization. User testing of OTC labels and consumer feedback received as part of the testing process can assist in the refinement of OTC labeling to ensure that implemented policies are evidence-based. Copyright © 2017 Elsevier Inc. All rights reserved.

Systematically Differentiating Functions for Alternatively Spliced Isoforms through Integrating RNA-seq Data

PubMed Central

Menon, Rajasree; Wen, Yuchen; Omenn, Gilbert S.; Kretzler, Matthias; Guan, Yuanfang

2013-01-01

Integrating large-scale functional genomic data has significantly accelerated our understanding of gene functions. However, no algorithm has been developed to differentiate functions for isoforms of the same gene using high-throughput genomic data. This is because standard supervised learning requires ‘ground-truth’ functional annotations, which are lacking at the isoform level. To address this challenge, we developed a generic framework that interrogates public RNA-seq data at the transcript level to differentiate functions for alternatively spliced isoforms. For a specific function, our algorithm identifies the ‘responsible’ isoform(s) of a gene and generates classifying models at the isoform level instead of at the gene level. Through cross-validation, we demonstrated that our algorithm is effective in assigning functions to genes, especially the ones with multiple isoforms, and robust to gene expression levels and removal of homologous gene pairs. We identified genes in the mouse whose isoforms are predicted to have disparate functionalities and experimentally validated the ‘responsible’ isoforms using data from mammary tissue. With protein structure modeling and experimental evidence, we further validated the predicted isoform functional differences for the genes Cdkn2a and Anxa6. Our generic framework is the first to predict and differentiate functions for alternatively spliced isoforms, instead of genes, using genomic data. It is extendable to any base machine learner and other species with alternatively spliced isoforms, and shifts the current gene-centered function prediction to isoform-level predictions. PMID:24244129

Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests.

PubMed

Schirmer, Kristin; Tanneberger, Katrin; Kramer, Nynke I; Völker, Doris; Scholz, Stefan; Hafner, Christoph; Lee, Lucy E J; Bols, Niels C; Hermens, Joop L M

2008-11-11

This paper details the derivation of a list of 60 reference chemicals for the development of alternatives to animal testing in ecotoxicology with a particular focus on fish. The chemicals were selected as a prerequisite to gather mechanistic information on the performance of alternative testing systems, namely vertebrate cell lines and fish embryos, in comparison to the fish acute lethality test. To avoid the need for additional experiments with fish, the U.S. EPA fathead minnow database was consulted as reference for whole organism responses. This database was compared to the Halle Registry of Cytotoxicity and a collation of data by the German EPA (UBA) on acute toxicity data derived from zebrafish embryos. Chemicals that were present in the fathead minnow database and in at least one of the other two databases were subject to selection. Criteria included the coverage of a wide range of toxicity and physico-chemical parameters as well as the determination of outliers of the in vivo/in vitro correlations. While the reference list of chemicals now guides our research for improving cell line and fish embryo assays to make them widely applicable, the list could be of benefit to search for alternatives in ecotoxicology in general. One example would be the use of this list to validate structure-activity prediction models, which in turn would benefit from a continuous extension of this list with regard to physico-chemical and toxicological data.

Calcium intercalation into layered fluorinated sodium iron phosphate

NASA Astrophysics Data System (ADS)

Lipson, Albert L.; Kim, Soojeong; Pan, Baofei; Liao, Chen; Fister, Timothy T.; Ingram, Brian J.

2017-11-01

The energy density and cost of battery systems, relative to the current state-of-the art, can be improved by developing alternative chemistries utilizing multivalent working ions such as calcium. Many challenges must be overcome, such as the identification of cathode materials with high energy density and an electrolyte with a wide electrochemical stability window that can plate and strip calcium metal, before market implementation. Herein, the feasibility and cycling performance of Ca2+ intercalation into a desodiated layered Na2FePO4F host is described. This is the first demonstration of Ca2+ intercalation into a polyanionic framework, which implies that other polyanionic framework materials may be active for Ca2+ intercalation. Although substantial effort is expected in order to develop a high energy density cathode material, this study demonstrates the feasibility of Ca2+ intercalation into multiple host structures types, thereby extending opportunities for development of Ca insertion host structures, suggesting such a cathode material can be identified and developed.

30 CFR 285.1016 - When will an Alternate Use RUE be cancelled?

Code of Federal Regulations, 2010 CFR

2010-07-01

... OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Rights of Use and Easement for Energy- and Marine-Related Activities Using Existing OCS Facilities Alternate Use... marine, coastal, or human environment; or sites, structures, or objects of historical or archaeological...

75 FR 24930 - Fort Bliss (Texas) Army Growth and Force Structure Realignment Final Environmental Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

... effects that would result from use of stationing and training capacity, land use changes, and training... 4 stationing action; Alternative 5 land use change; and Alternative 4 training infrastructure... stationing package. Alternative 5 land use changes allow fixed sites (e.g., military bivouac), mission...

46 CFR 116.340 - Alternate design considerations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Alternate design considerations. 116.340 Section 116.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS CONSTRUCTION AND ARRANGEMENT Hull Structure § 116.340 Alternate...

46 CFR 116.340 - Alternate design considerations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Alternate design considerations. 116.340 Section 116.340 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS CONSTRUCTION AND ARRANGEMENT Hull Structure § 116.340 Alternate...

Achieving biopolymer synergy in systems chemistry.

PubMed

Bai, Yushi; Chotera, Agata; Taran, Olga; Liang, Chen; Ashkenasy, Gonen; Lynn, David G

2018-05-31

Synthetic and materials chemistry initiatives have enabled the translation of the macromolecular functions of biology into synthetic frameworks. These explorations into alternative chemistries of life attempt to capture the versatile functionality and adaptability of biopolymers in new orthogonal scaffolds. Information storage and transfer, however, so beautifully represented in the central dogma of biology, require multiple components functioning synergistically. Over a single decade, the emerging field of systems chemistry has begun to catalyze the construction of mutualistic biopolymer networks, and this review begins with the foundational small-molecule-based dynamic chemical networks and peptide amyloid-based dynamic physical networks on which this effort builds. The approach both contextualizes the versatile approaches that have been developed to enrich chemical information in synthetic networks and highlights the properties of amyloids as potential alternative genetic elements. The successful integration of both chemical and physical networks through β-sheet assisted replication processes further informs the synergistic potential of these networks. Inspired by the cooperative synergies of nucleic acids and proteins in biology, synthetic nucleic-acid-peptide chimeras are now being explored to extend their informational content. With our growing range of synthetic capabilities, structural analyses, and simulation technologies, this foundation is radically extending the structural space that might cross the Darwinian threshold for the origins of life as well as creating an array of alternative systems capable of achieving the progressive growth of novel informational materials.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Boxiao; Tan, Xiao -Feng; Thurmond, Stephanie

The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alternative conformations of flavivirus NS5 proteins. In conclusion, the activity of this NS5 protein is verified through a de novo RdRp assay on a subgenomic ZIKV RNA template. Importantly, our structural analysis leads to the identification of a potential drug-binding site of ZIKV NS5, which might facilitate the development of novel antiviralsmore » for ZIKV.« less

Institutional and financial guide to geothermal district heating, serial no. 2

NASA Astrophysics Data System (ADS)

1982-03-01

General planning considerations which affect nearly every community are reviewed, and alternative operating structures which are available to communities are reviewed, including local governments, nonprofit cooperatives, private enterprises, and joint ventures. The financing options available to publicly-owned and privately-owned district heating systems are then summarized. The geothermal production and distribution activities most appropriate to each type of operating structure are reviewed, along with typical equity and debt funding sources. The tax advantages for private developers are described, as are the issues of customer contracts and service prices, and customer retrofit financing. The treatment is limited to an introductory overview.

Parallel processors and nonlinear structural dynamics algorithms and software

NASA Technical Reports Server (NTRS)

Belytschko, Ted; Gilbertsen, Noreen D.; Neal, Mark O.; Plaskacz, Edward J.

1989-01-01

The adaptation of a finite element program with explicit time integration to a massively parallel SIMD (single instruction multiple data) computer, the CONNECTION Machine is described. The adaptation required the development of a new algorithm, called the exchange algorithm, in which all nodal variables are allocated to the element with an exchange of nodal forces at each time step. The architectural and C* programming language features of the CONNECTION Machine are also summarized. Various alternate data structures and associated algorithms for nonlinear finite element analysis are discussed and compared. Results are presented which demonstrate that the CONNECTION Machine is capable of outperforming the CRAY XMP/14.

Two alternative ways for solving the coordination problem in multilevel optimization

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, Jaroslaw

1991-01-01

Two techniques for formulating the coupling between levels in multilevel optimization by linear decomposition, proposed as improvements over the original formulation, now several years old, that relied on explicit equality constraints which were shown by application experience as occasionally causing numerical difficulties. The two new techniques represent the coupling without using explicit equality constraints, thus avoiding the above diffuculties and also reducing computational cost of the procedure. The old and new formulations are presented in detail and illustrated by an example of a structural optimization. A generic version of the improved algorithm is also developed for applications to multidisciplinary systems not limited to structures.

Large scale surface flow generation in driven suspensions of magnetic microparticles: Experiment, theoretical model and simulations

NASA Astrophysics Data System (ADS)

Belkin, Maxim; Snezhko, Alexey; Aranson, Igor

2007-03-01

Nontrivially ordered dynamic self-assembled snake-like structures are formed in an ensemble of magnetic microparticles suspended over a fluid surface and energized by an external alternating magnetic field. Formation and existence of such structures is always accompanied by flows which form vortices. These large-scale vortices can be very fast and are crucial for snake formation/destruction. We introduce theoretical model based on Ginzburg-Landau equation for parametrically excited surface waves coupled to conservation law for particle density and Navier-Stokes equation for water flows. The developed model successfully describes snake generation, accounts for flows and reproduces most experimental results observed.

Advanced vehicles: Costs, energy use, and macroeconomic impacts

NASA Astrophysics Data System (ADS)

Wang, Guihua

Advanced vehicles and alternative fuels could play an important role in reducing oil use and changing the economy structure. We developed the Costs for Advanced Vehicles and Energy (CAVE) model to investigate a vehicle portfolio scenario in California during 2010-2030. Then we employed a computable general equilibrium model to estimate macroeconomic impacts of the advanced vehicle scenario on the economy of California. Results indicate that, due to slow fleet turnover, conventional vehicles are expected to continue to dominate the on-road fleet and gasoline is the major transportation fuel over the next two decades. However, alternative fuels could play an increasingly important role in gasoline displacement. Advanced vehicle costs are expected to decrease dramatically with production volume and technological progress; e.g., incremental costs for fuel cell vehicles and hydrogen could break even with gasoline savings in 2028. Overall, the vehicle portfolio scenario is estimated to have a slightly negative influence on California's economy, because advanced vehicles are very costly and, therefore, the resulting gasoline savings generally cannot offset the high incremental expenditure on vehicles and alternative fuels. Sensitivity analysis shows that an increase in gasoline price or a drop in alternative fuel prices could offset a portion of the negative impact.

The synthesis of monomers with pendent ethynyl groups for modified high performance thermoplastics

NASA Technical Reports Server (NTRS)

Nwokogu, Godson C.; Antoine, Miquel D.; Ansong, Omari

1994-01-01

Synthetic schemes were developed and optimized for twelve new monomers possessing unique structural features and one aspartimide. Two synthetic pathways were compared for preparation of the triarylethane monomers with pendent ethynyl groups. The results show that one of these pathways can be generally applied. The alternative pathway was applicable to the preparation of only one of the twelve compounds, the problem being secondary reactions of the initially formed desired product.