Personality disorders in DSM-5: emerging research on the alternative model.

PubMed

Morey, Leslie C; Benson, Kathryn T; Busch, Alexander J; Skodol, Andrew E

2015-04-01

The current categorical classification of personality disorders, originally introduced in the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), has been found to suffer from numerous shortcomings that hamper its usefulness for research and for clinical application. The Personality and Personality Disorders Work Group for DSM-5 was charged with developing an alternative model that would address many of these concerns. The developed model involved a hybrid dimensional/categorical model that represented personality disorders as combinations of core impairments in personality functioning with specific configurations of problematic personality traits. The Board of Trustees of the American Psychiatric Association did not accept the Task Force recommendation to implement this novel approach, and thus this alternative model was included in Sect. III of the DSM-5 among concepts requiring additional study. This review provides an overview of the emerging research on this alternative model, addressing each of the primary components of the model.

Forecasting models for sugi (Cryptomeria japonica D. Don) pollen count showing an alternate dispersal rhythm.

PubMed

Ito, Yukiko; Hattori, Reiko; Mase, Hiroki; Watanabe, Masako; Shiotani, Itaru

2008-12-01

Pollen information is indispensable for allergic individuals and clinicians. This study aimed to develop forecasting models for the total annual count of airborne pollen grains based on data monitored over the last 20 years at the Mie Chuo Medical Center, Tsu, Mie, Japan. Airborne pollen grains were collected using a Durham sampler. Total annual pollen count and pollen count from October to December (OD pollen count) of the previous year were transformed to logarithms. Regression analysis of the total pollen count was performed using variables such as the OD pollen count and the maximum temperature for mid-July of the previous year. Time series analysis revealed an alternate rhythm of the series of total pollen count. The alternate rhythm consisted of a cyclic alternation of an "on" year (high pollen count) and an "off" year (low pollen count). This rhythm was used as a dummy variable in regression equations. Of the three models involving the OD pollen count, a multiple regression equation that included the alternate rhythm variable and the interaction of this rhythm with OD pollen count showed a high coefficient of determination (0.844). Of the three models involving the maximum temperature for mid-July, those including the alternate rhythm variable and the interaction of this rhythm with maximum temperature had the highest coefficient of determination (0.925). An alternate pollen dispersal rhythm represented by a dummy variable in the multiple regression analysis plays a key role in improving forecasting models for the total annual sugi pollen count.

Probability model for analyzing fire management alternatives: theory and structure

Treesearch

Frederick W. Bratten

1982-01-01

A theoretical probability model has been developed for analyzing program alternatives in fire management. It includes submodels or modules for predicting probabilities of fire behavior, fire occurrence, fire suppression, effects of fire on land resources, and financial effects of fire. Generalized "fire management situations" are used to represent actual fire...

Three-Dimensional Magnetic Analysis Technique Developed for Evaluating Stirling Convertor Linear Alternators

NASA Technical Reports Server (NTRS)

Geng, Steven M.

2003-01-01

The Department of Energy, the Stirling Technology Company (STC), and the NASA Glenn Research Center are developing Stirling convertors for Stirling radioisotope generators to provide electrical power for future NASA deep space missions. STC is developing the 55-We technology demonstration convertor (TDC) under contract to the Department of Energy. The Department of Energy recently named Lockheed Martin as the system integration contractor for the Stirling radioisotope generator development project. Lockheed Martin will develop the Stirling radioisotope generator engineering unit and has contract options to develop the qualification unit and the first flight unit. Glenn s role includes an in-house project to provide convertor, component, and materials testing and evaluation in support of the overall power system development. As a part of this work, Glenn has established an in-house Stirling research laboratory for testing, analyzing, and evaluating Stirling machines. STC has built four 55-We convertors for NASA, and these are being tested at Glenn. A cross-sectional view of the 55-We TDC is shown in the figure. Of critical importance to the successful development of the Stirling convertor for space power applications is the development of a lightweight and highly efficient linear alternator. In support, Glenn has been developing finite element analysis and finite element method tools for performing various linear alternator thermal and electromagnetic analyses and evaluating design configurations. A three-dimensional magnetostatic finite element model of STC's 55-We TDC linear alternator was developed to evaluate the demagnetization fields affecting the alternator magnets. Since the actual linear alternator hardware is symmetric to the quarter section about the axis of motion, only a quarter section of the alternator was modeled. The components modeled included the mover laminations, the neodymium-iron-boron magnets, the stator laminations, and the copper coils. The three-dimensional magnetostatic model was then coupled with a circuit simulator model of the alternator load and convertor controller. The coupled model was then used to generate alternator terminal voltage and current predictions. The predicted voltage and current waveforms agreed well with the experimental data, which tended to validate the accuracy of the coupled model. The model was then used to generate predictions of the demagnetization fields acting on the alternator magnets for the alternator under load. The preliminary model predictions indicate that the highest potential for demagnetization is along the inside surface of the uncovered magnets. The demagnetization field for the uncovered magnets when the mover is positioned at the end of a stroke is higher than it is when the mover is at the position of maximum induced voltage or maximum alternator current. Assuming normal load conditions, the model predicted that the onset of demagnetization is most likely to occur for magnet temperatures above 101 C.

Evaluating model structure adequacy: The case of the Maggia Valley groundwater system, southern Switzerland

USGS Publications Warehouse

Hill, Mary C.; L. Foglia,; S. W. Mehl,; P. Burlando,

2013-01-01

Model adequacy is evaluated with alternative models rated using model selection criteria (AICc, BIC, and KIC) and three other statistics. Model selection criteria are tested with cross-validation experiments and insights for using alternative models to evaluate model structural adequacy are provided. The study is conducted using the computer codes UCODE_2005 and MMA (MultiModel Analysis). One recharge alternative is simulated using the TOPKAPI hydrological model. The predictions evaluated include eight heads and three flows located where ecological consequences and model precision are of concern. Cross-validation is used to obtain measures of prediction accuracy. Sixty-four models were designed deterministically and differ in representation of river, recharge, bedrock topography, and hydraulic conductivity. Results include: (1) What may seem like inconsequential choices in model construction may be important to predictions. Analysis of predictions from alternative models is advised. (2) None of the model selection criteria consistently identified models with more accurate predictions. This is a disturbing result that suggests to reconsider the utility of model selection criteria, and/or the cross-validation measures used in this work to measure model accuracy. (3) KIC displayed poor performance for the present regression problems; theoretical considerations suggest that difficulties are associated with wide variations in the sensitivity term of KIC resulting from the models being nonlinear and the problems being ill-posed due to parameter correlations and insensitivity. The other criteria performed somewhat better, and similarly to each other. (4) Quantities with high leverage are more difficult to predict. The results are expected to be generally applicable to models of environmental systems.

Changing Medicaid and Intermediate Care Facilities for the Mentally Retarded (ICF/MR): Evaluation of Alternatives.

ERIC Educational Resources Information Center

Fernald, Charles Denton

1986-01-01

Some alternatives for changing IFC are evaluated, and a model that can be used for considering other alternatives is presented. Proposals include a system of treatment protocols for diagnosis-related groups and a revision of S.873, The Community and Family Living Amendments of 1985. (Author/CL)

Exploring Dimensions of Social Inclusion among Alternative Learning Centres in the USA

ERIC Educational Resources Information Center

Henderson, Dawn X.; Barnes, Rachelle Redmond

2016-01-01

Increasing disparities in out-of-school suspension and dropout rates have led a number of school districts to develop alternative models of education to include alternative learning centres (ALCs). Using an exploratory mixed methods design, this study explores dimensions of social inclusion among ALCs, located in the southeastern region of the…

What Schooling Could Be Like: Analogies for Learning

ERIC Educational Resources Information Center

Engel, Martin

1974-01-01

A survey of alternative models of education is presented metaphorically. Alternatives suggested include schools more like mobile homes, teaching hospital complexes, summer camps, art classrooms, professional practice, a physician's practice, and libraries and museums. (SDH)

An Advanced Multiple Alternatives Modeling Formulation for Determining Graduated Fiscal Support Strategies for Operational and Planned Educational Programs.

ERIC Educational Resources Information Center

Wholeben, Brent Edward

A rationale is presented for viewing the decision-making process inherent in determining budget reductions for educational programs as most effectively modeled by a graduated funding approach. The major tenets of the graduated budget reduction approach to educational fiscal policy include the development of multiple alternative reduction plans, or…

Characterizing Particulate Matter Exfiltration Estimates for Alternative Cookstoves in a Village-Like Household in Rural Nepal.

PubMed

Soneja, Sutyajeet I; Tielsch, James M; Khatry, Subarna K; Zaitchik, Benjamin; Curriero, Frank C; Breysse, Patrick N

2017-11-01

Alternative stoves are an intervention option to reduce household air pollution. The amount of air pollution exiting homes when alternative stoves are utilized is not known. In this paper, particulate matter exfiltration estimates are presented for four types of alternative stoves within a village-like home, which was built to reflect the use of local materials and common size, in rural Nepal. Four alternative stoves with chimneys were examined, which included an alternative mud brick stove, original Envirofit G3355 model, manufacture altered Envirofit G3355, and locally altered Envirofit G3355. Multiple linear regression was utilized to determine estimates of PM2.5 exfiltration. Overall exfiltration fraction average (converted to a percent) for the four stoves were: alternative mud brick stove with chimney 56%, original Envirofit G3355 model with chimney 87%, manufacture altered Envirofit G3355 model with chimney 69%, and locally altered Envirofit G3355 model with chimney 69%. Alternative cookstoves resulted in higher overall average exfiltration due to direct and indirect ventilation relative to traditional, mud-based stoves. This contrast emphasizes the need for an improved understanding of the climate and health implications that are believed to come from implementing alternative stoves on a large scale and the resultant shift of exposure burden from indoors to outdoors.

Characterizing Particulate Matter Exfiltration Estimates for Alternative Cookstoves in a Village-Like Household in Rural Nepal

NASA Astrophysics Data System (ADS)

Soneja, Sutyajeet I.; Tielsch, James M.; Khatry, Subarna K.; Zaitchik, Benjamin; Curriero, Frank C.; Breysse, Patrick N.

2017-11-01

Alternative stoves are an intervention option to reduce household air pollution. The amount of air pollution exiting homes when alternative stoves are utilized is not known. In this paper, particulate matter exfiltration estimates are presented for four types of alternative stoves within a village-like home, which was built to reflect the use of local materials and common size, in rural Nepal. Four alternative stoves with chimneys were examined, which included an alternative mud brick stove, original Envirofit G3355 model, manufacture altered Envirofit G3355, and locally altered Envirofit G3355. Multiple linear regression was utilized to determine estimates of PM2.5 exfiltration. Overall exfiltration fraction average (converted to a percent) for the four stoves were: alternative mud brick stove with chimney 56%, original Envirofit G3355 model with chimney 87%, manufacture altered Envirofit G3355 model with chimney 69%, and locally altered Envirofit G3355 model with chimney 69%. Alternative cookstoves resulted in higher overall average exfiltration due to direct and indirect ventilation relative to traditional, mud-based stoves. This contrast emphasizes the need for an improved understanding of the climate and health implications that are believed to come from implementing alternative stoves on a large scale and the resultant shift of exposure burden from indoors to outdoors.

AAC Modeling Intervention Research Review

ERIC Educational Resources Information Center

Sennott, Samuel C.; Light, Janice C.; McNaughton, David

2016-01-01

A systematic review of research on the effects of interventions that include communication partner modeling of aided augmentative and alternative communication (AAC) on the language acquisition of individuals with complex communication needs was conducted. Included studies incorporated AAC modeling as a primary component of the intervention,…

Alternative Payment Models in Radiology: The Legislative and Regulatory Roadmap for Reform.

PubMed

Silva, Ezequiel; McGinty, Geraldine B; Hughes, Danny R; Duszak, Richard

2016-10-01

The Medicare Access and CHIP Reauthorization Act (MACRA) replaces the sustainable growth rate with a payment system based on the Merit-Based Incentive Payment System and incentives for alternative payment model participation. It is important that radiologists understand the statutory requirements of MACRA. This includes the nature of the Merit-Based Incentive Payment System composite performance score and its impact on payments. The timeline for MACRA implementation is fairly aggressive and includes a robust effort to define episode groups, which include radiologic services. A number of organizations, including the ACR, are commenting on the structure of MACRA-directed initiatives. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Alternative Z ' bosons in E 6

NASA Astrophysics Data System (ADS)

Rojas, Eduardo; Erler, Jens

2015-10-01

We classify the quantum numbers of the extra U(1)' symmetries contained in E 6. In particular, we categorize the cases with rational charges and present the full list of models which arise from the chains of the maximal subgroups of E 6. As an application, the classification allows us to determine all embeddings of the Standard Model fermions in all possible decompositions of the fundamental representation of E 6 under its maximal subgroups. From this we find alternative chains of subgroups for Grand Unified Theories. We show how many of the known models including some new ones appear in alternative breaking patterns. We also use low energy constraints coming from parity-violating asymmetry measurements and atomic parity non-conservation to set limits on the E 6 motivated parameter space for a Z ' boson mass of 1.2 TeV. We include projected limits for the present and upcoming QWEAK, MOLLER and SOLID experiments.

Predicting the Consequences of Workload Management Strategies with Human Performance Modeling

NASA Technical Reports Server (NTRS)

Mitchell, Diane Kuhl; Samma, Charneta

2011-01-01

Human performance modelers at the US Army Research Laboratory have developed an approach for establishing Soldier high workload that can be used for analyses of proposed system designs. Their technique includes three key components. To implement the approach in an experiment, the researcher would create two experimental conditions: a baseline and a design alternative. Next they would identify a scenario in which the test participants perform all their representative concurrent interactions with the system. This scenario should include any events that would trigger a different set of goals for the human operators. They would collect workload values during both the control and alternative design condition to see if the alternative increased workload and decreased performance. They have successfully implemented this approach for military vehicle. designs using the human performance modeling tool, IMPRINT. Although ARL researches use IMPRINT to implement their approach, it can be applied to any workload analysis. Researchers using other modeling and simulations tools or conducting experiments or field tests can use the same approach.

A model for evaluation of satellite population management alternatives

NASA Astrophysics Data System (ADS)

Penny, R. E., Jr.; Jones, R. K.

1983-12-01

A Q-GERT model was developed to simulate the satellite environment, including the untracked man-made population, and to calculate a probability of collision for any satellite of interest. Provision for launches, explosions, collisions (including ASAT), retrieval, reposition, and decay was made. The model is structured to easily vary the rates at which these activities occur and to observe changes in the satellite population through which a satellite of interest must travel. Variance of the rates, and the resultant change in probability of collision allows evaluation of satellite population management alternatives such as reducing launch rates or increasing retrieval of spent, but still capable of exploding, satellites. The model is proposed for use by both the USAF SPACE COMMAND and NASA.

Alternative Futures Analysis Of Farmington Bay Wetlands In The Great Salt Lake Ecosystem

EPA Science Inventory

An Alternative Futures Analysis (AFA) was conducted to evaluate tradeoffs between landscape design scenarios and ecological services for Farmington Bay, Great Salt Lake (GSL), wetlands. Model scenarios included both plan trend and conservation "futures" projected to 2030. Scena...

AN ALTERNATIVE FUTURES ANALYSIS OF FARMINGTON BAY WETLANDS IN THE GREAT SALT LAKE

EPA Science Inventory

An Alternative Futures Analysis (AFA) was conducted to evaluate tradeoffs between landscape design scenarios and ecological services for Farmington Bay, Great Salt Lake (GSL), wetlands. Model scenarios included plan trend and conservation "futures" scenarios projected to 2030. ...

Complementary and Alternative Therapies in ALS

PubMed Central

Bedlack, Richard S.; Joyce, Nanette; Carter, Gregory T.; Pagononi, Sabrina; Karam, Chafic

2015-01-01

Synopsis Given the severity of their illness and lack of effective disease modifying agents, it is not surprising that most patients with ALS consider trying complementary and alternative therapies. Some of the most commonly considered alternative therapies include special diets, nutritional supplements, cannabis, acupuncture, chelation and energy healing. This chapter reviews these in detail. We also describe 3 models by which physicians may frame discussions about alternative therapies: paternalism, autonomy and shared decision making. Finally, we review a program called ALSUntangled which using shared shared decision making to review alternative therapies for ALS. PMID:26515629

Alternative models of climatic effects on sockeye salmon (Oncorhynchus nerka) productivity in Bristol Bay, Alaska, and the Fraser River, British Columbia

USGS Publications Warehouse

Adkison, M.; Peterman, R.; Lapointe, M.; Gillis, D.; Korman, J.

1996-01-01

We compare alternative models of sockeye salmon (Oncorhynchus nerka) productivity (returns per spawner) using more than 30 years of catch and escapement data for Bristol Bay, Alaska, and the Fraser River, British Columbia. The models examined include several alternative forms of models that incorporate climatic influences as well as models not based on climate. For most stocks, a stationary stock-recruitment relationship explains very little of the interannual variation in productivity. In Bristol Bay, productivity co-varies among stocks and appears to be strongly related to fluctuations in climate. The best model for Bristol Bay sockeye involved a change in the 1970s in the parameters of the Ricker stock-recruitment curve; the stocks generally became more productive. In contrast, none of the models of Fraser River stocks that we examined explained much of the variability in their productivity.

Bundled payment and enhanced recovery after surgery.

PubMed

Huang, Jeffrey

2015-01-01

Medicare's fee-for-service (FFS) payment model may contribute to unsustainable spending growth. Payers are turning to alternative payment methods. The leading alternative payment model to the FFS problem is bundled payment. The Centers for Medicare & Medicaid Services (CMS) is taking another step to improve healthcare quality at lower cost. The CMS's Center for Medicare and Medicaid Innovation developed four models of bundled payments and 48 discrete clinical condition episodes. Many surgical care procedures are included in the 48 different clinical condition episodes.

Models of antenatal care to reduce and prevent preterm birth: a systematic review and meta-analysis.

PubMed

Fernandez Turienzo, Cristina; Sandall, Jane; Peacock, Janet L

2016-01-12

To assess the effectiveness of models of antenatal care designed to prevent and reduce preterm birth (PTB) in pregnant women. We conducted a search of seven electronic databases and reference lists of retrieved studies to identify trials from inception up to July 2014 where pregnant women, regardless of risk factors for pregnancy complications, were randomly allocated to receive an alternative model of antenatal care or routine care. We pooled risks of PTB to determine the effect of alternative care models in all pregnant women. We also assessed secondary maternal and infant outcomes, women's satisfaction and economic outcomes. 15 trials involving 22,437 women were included. Pregnant women in alternative care models were less likely to experience PTB (risk ratio 0.84, 95% CI 0.74 to 0.96). The subgroup of women randomised to midwife-led continuity models of antenatal care were less likely to experience PTB (0.78, 0.66 to 0.91) but there was no significant difference between this group and women allocated to specialised care (0.92, 0.76 to 1.12) (interaction test for subgroup differences p=0.20). Overall low-risk women in alternative care models were less likely to have PTB (0.74, 0.59 to 0.93), but this effect was not significantly different from that in mixed-risk populations (0.91, 0.79 to 1.05) (subgroup p=0.13). Alternative models of antenatal care for all pregnant women are effective in reducing PTB compared with routine care, but no firm conclusions could be drawn regarding the relative benefits of the two models. Future research should evaluate the impact of antenatal care models which include more recent interventions and predictive tests, and which also offer continuity of care by midwives throughout pregnancy. CRD42014007116. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Air pollution exposure prediction approaches used in air pollution epidemiology studies.

PubMed

Özkaynak, Halûk; Baxter, Lisa K; Dionisio, Kathie L; Burke, Janet

2013-01-01

Epidemiological studies of the health effects of outdoor air pollution have traditionally relied upon surrogates of personal exposures, most commonly ambient concentration measurements from central-site monitors. However, this approach may introduce exposure prediction errors and misclassification of exposures for pollutants that are spatially heterogeneous, such as those associated with traffic emissions (e.g., carbon monoxide, elemental carbon, nitrogen oxides, and particulate matter). We review alternative air quality and human exposure metrics applied in recent air pollution health effect studies discussed during the International Society of Exposure Science 2011 conference in Baltimore, MD. Symposium presenters considered various alternative exposure metrics, including: central site or interpolated monitoring data, regional pollution levels predicted using the national scale Community Multiscale Air Quality model or from measurements combined with local-scale (AERMOD) air quality models, hybrid models that include satellite data, statistically blended modeling and measurement data, concentrations adjusted by home infiltration rates, and population-based human exposure model (Stochastic Human Exposure and Dose Simulation, and Air Pollutants Exposure models) predictions. These alternative exposure metrics were applied in epidemiological applications to health outcomes, including daily mortality and respiratory hospital admissions, daily hospital emergency department visits, daily myocardial infarctions, and daily adverse birth outcomes. This paper summarizes the research projects presented during the symposium, with full details of the work presented in individual papers in this journal issue.

A new 3D reconstituted human corneal epithelium model as an alternative method for the eye irritation test.

PubMed

Jung, Kyoung-Mi; Lee, Su-Hyon; Ryu, Yang-Hwan; Jang, Won-Hee; Jung, Haeng-Sun; Han, Ju-Hee; Seok, Seung-Hyeok; Park, Jae-Hak; Son, Youngsook; Park, Young-Ho; Lim, Kyung-Min

2011-02-01

Many efforts are being made to develop new alternative in vitro test methods for the eye irritation test. Here we report a new reconstructed human corneal epithelial model (MCTT HCE model) prepared from primary-cultured human limbal epithelial cells as a new alternative in vitro eye irritation test method. In histological and immunohistochemical observation, MCTT HCE model displayed a morphology and biomarker expressions similar to intact human cornea. Moreover, the barrier function was well preserved as measured by high transepithelial electrical resistance, effective time-50 for Triton X-100, and corneal thickness. To employ the model as a new alternative method for eye irritation test, protocol refinement was performed and optimum assay condition was determined including treatment time, treatment volume, post-incubation time and rinsing method. Using the refined protocol, 25 reference chemicals with known eye irritation potentials were tested. With the viability cut-off value at 50%, chemicals were classified to irritant or non-irritant. When compared with GHS classification, the MCTT HCE model showed the accuracy of 88%, sensitivity of 100% and specificity of 77%. These results suggest that the MCTT HCE model might be useful as a new alternative eye irritation test method. Copyright © 2010 Elsevier Ltd. All rights reserved.

Comparing multi-criteria decision analysis and integrated assessment to support long-term water supply planning

PubMed Central

Maurer, Max; Lienert, Judit

2017-01-01

We compare the use of multi-criteria decision analysis (MCDA)–or more precisely, models used in multi-attribute value theory (MAVT)–to integrated assessment (IA) models for supporting long-term water supply planning in a small town case study in Switzerland. They are used to evaluate thirteen system scale water supply alternatives in four future scenarios regarding forty-four objectives, covering technical, social, environmental, and economic aspects. The alternatives encompass both conventional and unconventional solutions and differ regarding technical, spatial and organizational characteristics. This paper focuses on the impact assessment and final evaluation step of the structured MCDA decision support process. We analyze the performance of the alternatives for ten stakeholders. We demonstrate the implications of model assumptions by comparing two IA and three MAVT evaluation model layouts of different complexity. For this comparison, we focus on the validity (ranking stability), desirability (value), and distinguishability (value range) of the alternatives given the five model layouts. These layouts exclude or include stakeholder preferences and uncertainties. Even though all five led us to identify the same best alternatives, they did not produce identical rankings. We found that the MAVT-type models provide higher distinguishability and a more robust basis for discussion than the IA-type models. The needed complexity of the model, however, should be determined based on the intended use of the model within the decision support process. The best-performing alternatives had consistently strong performance for all stakeholders and future scenarios, whereas the current water supply system was outperformed in all evaluation layouts. The best-performing alternatives comprise proactive pipe rehabilitation, adapted firefighting provisions, and decentralized water storage and/or treatment. We present recommendations for possible ways of improving water supply planning in the case study and beyond. PMID:28481881

The bottom-up approach to integrative validity: a new perspective for program evaluation.

PubMed

Chen, Huey T

2010-08-01

The Campbellian validity model and the traditional top-down approach to validity have had a profound influence on research and evaluation. That model includes the concepts of internal and external validity and within that model, the preeminence of internal validity as demonstrated in the top-down approach. Evaluators and researchers have, however, increasingly recognized that in an evaluation, the over-emphasis on internal validity reduces that evaluation's usefulness and contributes to the gulf between academic and practical communities regarding interventions. This article examines the limitations of the Campbellian validity model and the top-down approach and provides a comprehensive, alternative model, known as the integrative validity model for program evaluation. The integrative validity model includes the concept of viable validity, which is predicated on a bottom-up approach to validity. This approach better reflects stakeholders' evaluation views and concerns, makes external validity workable, and becomes therefore a preferable alternative for evaluation of health promotion/social betterment programs. The integrative validity model and the bottom-up approach enable evaluators to meet scientific and practical requirements, facilitate in advancing external validity, and gain a new perspective on methods. The new perspective also furnishes a balanced view of credible evidence, and offers an alternative perspective for funding. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

A proposed model for economic evaluations of major depressive disorder.

PubMed

Haji Ali Afzali, Hossein; Karnon, Jonathan; Gray, Jodi

2012-08-01

In countries like UK and Australia, the comparability of model-based analyses is an essential aspect of reimbursement decisions for new pharmaceuticals, medical services and technologies. Within disease areas, the use of models with alternative structures, type of modelling techniques and/or data sources for common parameters reduces the comparability of evaluations of alternative technologies for the same condition. The aim of this paper is to propose a decision analytic model to evaluate long-term costs and benefits of alternative management options in patients with depression. The structure of the proposed model is based on the natural history of depression and includes clinical events that are important from both clinical and economic perspectives. Considering its greater flexibility with respect to handling time, discrete event simulation (DES) is an appropriate simulation platform for modelling studies of depression. We argue that the proposed model can be used as a reference model in model-based studies of depression improving the quality and comparability of studies.

Prognosis model for stand development

Treesearch

Albert R. Stage

1973-01-01

Describes a set of computer programs for developing prognoses of the development of existing stand under alternative regimes of management. Calibration techniques, modeling procedures, and a procedure for including stochastic variation are described. Implementation of the system for lodgepole pine, including assessment of losses attributed to an infestation of mountain...

A Subjective Assessment of Alternative Mission Architecture Operations Concepts for the Human Exploration of Mars at NASA Using a Three-Dimensional Multi-Criteria Decision Making Model

NASA Technical Reports Server (NTRS)

Tavana, Madjid

2003-01-01

The primary driver for developing missions to send humans to other planets is to generate significant scientific return. NASA plans human planetary explorations with an acceptable level of risk consistent with other manned operations. Space exploration risks can not be completely eliminated. Therefore, an acceptable level of cost, technical, safety, schedule, and political risks and benefits must be established for exploratory missions. This study uses a three-dimensional multi-criteria decision making model to identify the risks and benefits associated with three alternative mission architecture operations concepts for the human exploration of Mars identified by the Mission Operations Directorate at Johnson Space Center. The three alternatives considered in this study include split, combo lander, and dual scenarios. The model considers the seven phases of the mission including: 1) Earth Vicinity/Departure; 2) Mars Transfer; 3) Mars Arrival; 4) Planetary Surface; 5) Mars Vicinity/Departure; 6) Earth Transfer; and 7) Earth Arrival. Analytic Hierarchy Process (AHP) and subjective probability estimation are used to captures the experts belief concerning the risks and benefits of the three alternative scenarios through a series of sequential, rational, and analytical processes.

Heat-flow properties of systems with alternate masses or alternate on-site potentials.

PubMed

Pereira, Emmanuel; Santana, Leonardo M; Ávila, Ricardo

2011-07-01

We address a central issue of phononics: the search of properties or mechanisms to manage the heat flow in reliable materials. We analytically study standard and simple systems modeling the heat flow in solids, namely, the harmonic, self-consistent harmonic and also anharmonic chains of oscillators, and we show an interesting insulating effect: While in the homogeneous models the heat flow decays as the inverse of the particle mass, in the chain with alternate masses it decays as the inverse of the square of the mass difference, that is, it decays essentially as the mass ratio (between the smaller and the larger one) for a large mass difference. A similar effect holds if we alternate on-site potentials instead of particle masses. The existence of such behavior in these different systems, including anharmonic models, indicates that it is a ubiquitous phenomenon with applications in the heat flow control.

Telecommunications and the Classroom: Where We've Been and Where We Should Be Going.

ERIC Educational Resources Information Center

Goldberg, Fred S.

1988-01-01

Discussion of the use of telecommunications highlights projects designed by the New York City Board of Education to investigate telecommunications alternatives for the classroom. Telecommunications systems models are described, including electronic bulletin boards and networking; and instructional models are explained, including computer mediated…

Using the Landlab toolkit to evaluate and compare alternative geomorphic and hydrologic model formulations

NASA Astrophysics Data System (ADS)

Tucker, G. E.; Adams, J. M.; Doty, S. G.; Gasparini, N. M.; Hill, M. C.; Hobley, D. E. J.; Hutton, E.; Istanbulluoglu, E.; Nudurupati, S. S.

2016-12-01

Developing a better understanding of catchment hydrology and geomorphology ideally involves quantitative hypothesis testing. Often one seeks to identify the simplest mathematical and/or computational model that accounts for the essential dynamics in the system of interest. Development of alternative hypotheses involves testing and comparing alternative formulations, but the process of comparison and evaluation is made challenging by the rigid nature of many computational models, which are often built around a single assumed set of equations. Here we review a software framework for two-dimensional computational modeling that facilitates the creation, testing, and comparison of surface-dynamics models. Landlab is essentially a Python-language software library. Its gridding module allows for easy generation of a structured (raster, hex) or unstructured (Voronoi-Delaunay) mesh, with the capability to attach data arrays to particular types of element. Landlab includes functions that implement common numerical operations, such as gradient calculation and summation of fluxes within grid cells. Landlab also includes a collection of process components, which are encapsulated pieces of software that implement a numerical calculation of a particular process. Examples include downslope flow routing over topography, shallow-water hydrodynamics, stream erosion, and sediment transport on hillslopes. Individual components share a common grid and data arrays, and they can be coupled through the use of a simple Python script. We illustrate Landlab's capabilities with a case study of Holocene landscape development in the northeastern US, in which we seek to identify a collection of model components that can account for the formation of a series of incised canyons that have that developed since the Laurentide ice sheet last retreated. We compare sets of model ingredients related to (1) catchment hydrologic response, (2) hillslope evolution, and (3) stream channel and gully incision. The case-study example demonstrates the value of exploring multiple working hypotheses, in the form of multiple alternative model components.

Design of internal support structures for an inflatable lunar habitat

NASA Technical Reports Server (NTRS)

Cameron, Elizabeth A.; Duston, John A.; Lee, David D.

1990-01-01

NASA has a long range goal of constructing a fully equipped, manned lunar outpost on the near side of the moon by the year 2015. The proposed outpost includes an inflatable lunar habitat to support crews during missions longer that 12 months. A design for the internal support structures of the inflatable habitat is presented. The design solution includes material selection, substructure design, assembly plan development, and concept scale model construction. Alternate designs and design solutions for each component of the design are discussed. Alternate materials include aluminum, titanium, and reinforced polymers. Vertical support alternates include column systems, truss systems, suspension systems, and lunar lander supports. Horizontal alternates include beams, trusses, floor/truss systems, and expandable trusses. Feasibility studies on each alternate showed that truss systems and expandable trusses were the most feasible candidates for conceptual design. The team based the designs on the properties of 7075 T73 aluminum. The substructure assembly plan, minimizes assembly time and allows crews to construct the habitat without the use of EVA suits. In addition to the design solutions, the report gives conclusions and recommendations for further study of the inflatable habitat design.

Multilevel Modeling of Social Segregation

ERIC Educational Resources Information Center

Leckie, George; Pillinger, Rebecca; Jones, Kelvyn; Goldstein, Harvey

2012-01-01

The traditional approach to measuring segregation is based upon descriptive, non-model-based indices. A recently proposed alternative is multilevel modeling. The authors further develop the argument for a multilevel modeling approach by first describing and expanding upon its notable advantages, which include an ability to model segregation at a…

Methods in Enzymology: “Flexible backbone sampling methods to model and design protein alternative conformations”

PubMed Central

Ollikainen, Noah; Smith, Colin A.; Fraser, James S.; Kortemme, Tanja

2013-01-01

Sampling alternative conformations is key to understanding how proteins work and engineering them for new functions. However, accurately characterizing and modeling protein conformational ensembles remains experimentally and computationally challenging. These challenges must be met before protein conformational heterogeneity can be exploited in protein engineering and design. Here, as a stepping stone, we describe methods to detect alternative conformations in proteins and strategies to model these near-native conformational changes based on backrub-type Monte Carlo moves in Rosetta. We illustrate how Rosetta simulations that apply backrub moves improve modeling of point mutant side chain conformations, native side chain conformational heterogeneity, functional conformational changes, tolerated sequence space, protein interaction specificity, and amino acid co-variation across protein-protein interfaces. We include relevant Rosetta command lines and RosettaScripts to encourage the application of these types of simulations to other systems. Our work highlights that critical scoring and sampling improvements will be necessary to approximate conformational landscapes. Challenges for the future development of these methods include modeling conformational changes that propagate away from designed mutation sites and modulating backbone flexibility to predictively design functionally important conformational heterogeneity. PMID:23422426

NAVS Alternatives Set the Standard for Humane Education.

ERIC Educational Resources Information Center

Petty, Linda

1997-01-01

Describes some alternatives to dissection offered to teachers through the National Anti-Vivisection Society (NAVS) and other sources. These include models, CD-ROMs, and software that enable students to click on scalpels, scissors, and other instruments to cut through videotaped specimens. Also details the Dissection Hotline and the Dissection…

An Alternative Proposal for the Graphical Representation of Anticolor Charge

ERIC Educational Resources Information Center

Wiener, Gergried J.; Schmeling, Sascha M.; Hopf, Martin

2017-01-01

We have developed a learning unit based on the Standard Model of particle physics, featuring novel typographic illustrations of elementary particles and particle systems. Since the unit includes antiparticles and systems of antiparticles, a visualization of anticolor charge was required. We propose an alternative to the commonly used…

Simulation of fault performance of a diesel engine driven brushless alternator through PSPICE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayanan, S.S.Y.; Ananthakrishnan, P.; Hangari, V.U.

1995-12-31

Analysis of the fault performance of a brushless alternator with damper windings in the main alternator has been handled ab initio as a total modeling and simulation problem through proper application of Park`s equivalent circuit approach individually to the main exciter alternator units of the brushless alternator and the same has been implemented through PSPICE. The accuracy of the parameters used in the modeling and results obtained through PSPICE implementation are then evaluated for a specific 125 kVA brushless alternator in two stages as followed: first, by comparison of the predicted fault performance obtained from simulation of the 125 kVAmore » main alternator alone treated as a conventional alternator with the results obtained through the use of closed form analytical expressions available in the literature for fault currents and torques in such conventional alternators. Secondly, by comparison of some of the simulation results with those obtained experimentally on the brushless alternator itself. To enable proper calculation of derating factors to be used in the design of such brushless alternators, simulation results then include harmonic analysis of the steady state fault currents and torques. Throughout these studies, the brushless alternator is treated to be on no load at the instant of occurrence of fault.« less

The Sheperd equation and chaos identification.

PubMed

Gregson, Robert A M

2010-04-01

An equation created by Sheperd (1982) to model stability in exploited fish populations has been found to have a wider application, and it exhibits complicated internal dynamics, including phases of strict periodicity and of chaos. It may be potentially applicable to other psychophysiological contexts. The problems of determining goodness-of fit, and the comparative performance of alternative models including the Shephed model, are briefly addressed.

Bridging the gap between habitat-modeling research and bird conservation with dynamic landscape and population models

Treesearch

Frank R., III Thompson

2009-01-01

Habitat models are widely used in bird conservation planning to assess current habitat or populations and to evaluate management alternatives. These models include species-habitat matrix or database models, habitat suitability models, and statistical models that predict abundance. While extremely useful, these approaches have some limitations.

AAC Modeling with the iPad during Shared Storybook Reading Pilot Study

ERIC Educational Resources Information Center

Sennott, Samuel C.; Mason, Linda H.

2016-01-01

This pilot study describes an intervention package, MODELER for Read and Talk, designed to provide enriched language interaction for children with complex communication needs who require augmentative and alternative communication (AAC). MODELER (Model, Encourage, Respond) includes (a) modeling AAC as you speak, (b) encouraging communication…

Problems With Risk Reclassification Methods for Evaluating Prediction Models

PubMed Central

Pepe, Margaret S.

2011-01-01

For comparing the performance of a baseline risk prediction model with one that includes an additional predictor, a risk reclassification analysis strategy has been proposed. The first step is to cross-classify risks calculated according to the 2 models for all study subjects. Summary measures including the percentage of reclassification and the percentage of correct reclassification are calculated, along with 2 reclassification calibration statistics. The author shows that interpretations of the proposed summary measures and P values are problematic. The author's recommendation is to display the reclassification table, because it shows interesting information, but to use alternative methods for summarizing and comparing model performance. The Net Reclassification Index has been suggested as one alternative method. The author argues for reporting components of the Net Reclassification Index because they are more clinically relevant than is the single numerical summary measure. PMID:21555714

Hydrodynamic Modeling for Channel and Shoreline Stabilization at Rhodes Point, Smith Island, MD

DTIC Science & Technology

2016-11-01

shorelines. Both Alternatives included the same revetment structure for protecting the south shoreline. The Coastal Modeling System (CMS, including CMS...ER D C/ CH L TR -1 6- 17 Coastal Inlets Research Program Hydrodynamic Modeling for Channel and Shoreline Stabilization at Rhodes Point...acwc.sdp.sirsi.net/client/default. Coastal Inlets Research Program ERDC/CHL TR-16-17 November 2016 Hydrodynamic Modeling for Channel and Shoreline

Participatory modeling and structured decision making

USGS Publications Warehouse

Robinson, Kelly F.; Fuller, Angela K.

2016-01-01

Structured decision making (SDM) provides a framework for making sound decisions even when faced with uncertainty, and is a transparent, defensible, and replicable method used to understand complex problems. A hallmark of SDM is the explicit incorporation of values and science, which often includes participation from multiple stakeholders, helping to garner trust and ultimately result in a decision that is more likely to be implemented. The core steps in the SDM process are used to structure thinking about natural resources management choices, and include: (1) properly defining the problem and the decision context, (2) determining the objectives that help describe the aspirations of the decision maker, (3) devising management actions or alternatives that can achieve those objectives, (4) evaluating the outcomes or consequences of each alternative on each of the objectives, (5) evaluating trade-offs, and (6) implementing the decision. Participatory modeling for SDM includes engaging stakeholders in some or all of the steps of the SDM process listed above. In addition, participatory modeling often is crucial for creating qualitative and quantitative models of how the system works, providing data for these models, and eliciting expert opinion when data are unavailable. In these ways, SDM provides a framework for decision making in natural resources management that includes participation from stakeholder groups throughout the process, including the modeling phase.

Fish as research tools: alternatives to in vivo experiments.

PubMed

Schaeck, Marlien; Van den Broeck, Wim; Hermans, Katleen; Decostere, Annemie

2013-07-01

The use of fish in scientific research is increasing worldwide, due to both the rapid expansion of the fish farming industry and growing awareness of questions concerning the humane use of mammalian models in basic research and chemical testing. As fish are lower on the evolutionary scale than mammals, they are considered to be less sentient. Fish models are providing researchers, and those concerned with animal welfare, with opportunities for adhering to the Three Rs principles of refinement, reduction and replacement. However, it should be kept in mind that fish should also be covered by the principles of the Three Rs. Indeed, various studies have shown that fish are capable of nociception, and of experiencing pain in a manner analogous to that in mammals. Thus, emphasis needs to be placed on the development of alternatives that replace, as much as possible, the use of all living vertebrate animals, including fish. This review gives the first comprehensive and critical overview of the existing alternatives for live fish experimental studies. The alternative methods described range from cell and tissue cultures, organ and perfusion models, and embryonic models, to in silico computer and mathematical models. This article aspires to guide scientists in the adoption of the correct alternative methods in their research, and, whenever possible, to reduce the use of live fish. 2013 FRAME.

The Use of Complementary and Alternative Therapies by the Families of Children with Chronic Conditions and Disabilities.

ERIC Educational Resources Information Center

Nickel, Robert E.; Gerlach, Elizabeth King

2001-01-01

This article presents a model for communication among providers and families of children with disabilities about complementary and alternative medicine (CAM). It discusses treatments for children with attention deficit hyperactivity disorder and cerebral palsy, including the Feingold diet, herbal treatments, CranioSacral therapy, therapeutic…

Collective Action and the Development of Social Individuality in Women.

ERIC Educational Resources Information Center

Lykes, M. Brinton

Critics of a dominant model of the person, which emphasizes autonomy and independence, have called for an alternative, more social, conceptualization of the self. To describe and validate social individuality as an alternative conceptualization of the self, 84 adults (54 females, 30 males), from a range of social classes and including persons…

Using Simulations to Investigate the Longitudinal Stability of Alternative Schemes for Classifying and Identifying Children with Reading Disabilities

ERIC Educational Resources Information Center

Schatschneider, Christopher; Wagner, Richard K.; Hart, Sara A.; Tighe, Elizabeth L.

2016-01-01

The present study employed data simulation techniques to investigate the 1-year stability of alternative classification schemes for identifying children with reading disabilities. Classification schemes investigated include low performance, unexpected low performance, dual-discrepancy, and a rudimentary form of constellation model of reading…

Risk in fire management decisionmaking: techniques and criteria

Treesearch

Gail Blatternberger; William F. Hyde; Thomas J. Mills

1984-01-01

In the past, decisionmaking in wildland fire management generally has not included a full consideration of the risk and uncertainty that is inherent in evaluating alternatives. Fire management policies in some Federal land management agencies now require risk evaluation. The model for estimating the economic efficiency of fire program alternatives is the minimization...

Analysis of alternative modifications for reducing backwater at the Interstate Highway 10 crossing of the Pearl River near Slidell, Louisiana

USGS Publications Warehouse

Wiche, Gregg J.; Gilbert, J.J.; Froehlich, David C.; Lee, Jonathan K.

1988-01-01

In April 1979 and April 1980, major flooding along the lower Pearl River caused extensive damage to homes located on the flood plain in the Slidell, Louisiana, area. In response to questions about causes of these floods and means of mitigating future floods, the U.S. Geological Survey, in cooperation with the Louisiana Department of Transportation and Development, Office of Highways, and the U.S. Department of Transportation, Federal Highway Administration, used a two-dimensional finite-element surface-water flow-modeling system to study the effect of four alternative modifications for improving the hydraulic characteristics of the Interstate Highway 10 crossing of the flood plain near Slidell. The analysis used the model's capability to simulate changes in flood-plain topography, flood-plain vegetative cover, and highway-embankment geometry. Compared with the existing highway crossing, the four alternative modifications reduce backwater and average velocities through bridge openings for a flood of the magnitude of the 1980 flood. The four alternatives also eliminate roadway overtopping during such a flood. For the four modifications, maximum backwater on the west side of the flood plain ranges from 0.3 to 1.1 feet and on the east side from 0.3 to 0.7 foot. Results of the alternative-model simulations show that backwater is greater on the west side of the flood plain than on the east side, but upstream from Interstate Highway 10 backwater decreases more rapidly in the upstream direction on the west side of the flood plain than on the east side. Downstream from Interstate Highway 10, modeling of the four alternatives indicates that backwater and drawdown still occur on the east and west sides of the flood plain, respectively, but are less than the values computed for the April 1980 flood with Interstate Highway 10 in place. In addition to other highway-crossing modifications, alternatives 2 and 3 include simulation of a new 2,000-foot bridge opening, and ,alternative 4 includes simulation of a 1,000-foot bridge opening. The new bridge conveys 25, 23, and 21 percent of the total computed discharge in alternatives 2, 3, and 4, respectively. The average velocity through the new bridge is 2.0, 1.9, and 3.4 feet per second for alternatives 2, 3, and 4, respectively.

INTERCOMPARISON OF ALTERNATIVE VEGETATION DATABASES FOR REGIONAL AIR QUALITY MODELING

EPA Science Inventory

Vegetation cover data are used to characterize several regional air quality modeling processes, including the calculation of heat, moisture, and momentum fluxes with the Mesoscale Meteorological Model (MM5) and the estimate of biogenic volatile organic compound and nitric oxide...

Comparison of LIDAR system performance for alternative single-mode receiver architectures: modeling and experimental validation

NASA Astrophysics Data System (ADS)

Toliver, Paul; Ozdur, Ibrahim; Agarwal, Anjali; Woodward, T. K.

2013-05-01

In this paper, we describe a detailed performance comparison of alternative single-pixel, single-mode LIDAR architectures including (i) linear-mode APD-based direct-detection, (ii) optically-preamplified PIN receiver, (iii) PINbased coherent-detection, and (iv) Geiger-mode single-photon-APD counting. Such a comparison is useful when considering next-generation LIDAR on a chip, which would allow one to leverage extensive waveguide-based structures and processing elements developed for telecom and apply them to small form-factor sensing applications. Models of four LIDAR transmit and receive systems are described in detail, which include not only the dominant sources of receiver noise commonly assumed in each of the four detection limits, but also additional noise terms present in realistic implementations. These receiver models are validated through the analysis of detection statistics collected from an experimental LIDAR testbed. The receiver is reconfigurable into four modes of operation, while transmit waveforms and channel characteristics are held constant. The use of a diffuse hard target highlights the importance of including speckle noise terms in the overall system analysis. All measurements are done at 1550 nm, which offers multiple system advantages including less stringent eye safety requirements and compatibility with available telecom components, optical amplification, and photonic integration. Ultimately, the experimentally-validated detection statistics can be used as part of an end-to-end system model for projecting rate, range, and resolution performance limits and tradeoffs of alternative integrated LIDAR architectures.

The ecology of population dispersal: Modeling alternative basin-plateau foraging strategies to explain the Numic expansion.

PubMed

Magargal, Kate E; Parker, Ashley K; Vernon, Kenneth Blake; Rath, Will; Codding, Brian F

2017-07-08

The expansion of Numic speaking populations into the Great Basin required individuals to adapt to a relatively unproductive landscape. Researchers have proposed numerous social and subsistence strategies to explain how and why these settlers were able to replace any established populations, including private property and intensive plant processing. Here we evaluate these hypotheses and propose a new strategy involving the use of landscape fire to increase resource encounter rates. Implementing a novel, spatially explicit, multi-scalar prey choice model, we examine how individual decisions approximating each alternative strategy (private property, anthropogenic fire, and intensive plant processing) would aggregate at the patch and band level to confer an overall benefit to this colonizing population. Analysis relies on experimental data reporting resource profitability and abundance, ecological data on the historic distribution of vegetation patches, and ethnohistoric data on the distribution of Numic bands. Model results show that while resource privatization and landscape fires produce a substantial advantage, intensified plant processing garners the greatest benefit. The relative benefits of alternative strategies vary significantly across ecological patches resulting in variation across ethnographic band ranges. Combined, a Numic strategy including all three alternatives would substantially increase subsistence yields. The application of a strategy set that includes landscape fire, privatization and intensified processing of seeds and nuts, explains why the Numa were able to outcompete local populations. This approach provides a framework to help explain how individual decisions can result in such population replacement events throughout human history. © 2017 Wiley Periodicals, Inc.

Modelling the effect of an alternative host population on the spread of citrus Huanglongbing

NASA Astrophysics Data System (ADS)

d'A. Vilamiu, Raphael G.; Ternes, Sonia; Laranjeira, Francisco F.; de C. Santos, Tâmara T.

2013-10-01

The objective of this work was to model the spread of citrus Huanglongbing (HLB) considering the presence of a population of alternative hosts (Murraya paniculata). We developed a compartmental deterministic mathematical model for representing the dynamics of HLB disease in a citrus orchard, including delays in the latency and incubation phases of the disease in the plants and a delay period on the nymphal stage of Diaphorina citri, the insect vector of HLB in Brazil. The results of numerical simulations indicate that alternative hosts should not play a crucial role on HLB dynamics considering a typical scenario for the Recôncavo Baiano region in Brazil . Also, the current policy of removing symptomatic plants every three months should not be expected to significantly hinder HLB spread.

An integrative feminist model: the evolving feminist perspective on intimate partner violence.

PubMed

McPhail, Beverly A; Busch, Noël Bridget; Kulkarni, Shanti; Rice, Gail

2007-08-01

The feminist perspective on intimate partner violence is a predominant model in the field, although not immune to criticism. In this research, frontline workers in the violence against women movement responded to critiques of the feminist model. The project used a focus group and a modified grounded theory analysis. Participants agreed with some criticisms, including an overreliance on a punitive criminal justice system, but reported skepticism toward proposed alternatives. Findings led to the development of the Integrative Feminist Model, which expands the feminist perspective in response to critiques, new research, and alternative theories while retaining a gendered analysis of violence.

Economic feasibility of alternative practitioners for provision of dental care to the underserved.

PubMed

Matthiesen, Anne

2012-01-01

This study assesses the viability of three alternative practitioner types for provision of dental care to the underserved. Key factors modeled include compensation, training and practice costs, productivity, and payer mix scenarios. Utilizing dental therapists or dental health aide therapists is cost-effective for enhancing access. However, to be sustainable, the practices will require a subsidy or a better reimbursement than modeled. Without tuition support, the debt burden will deter applicants mostlikely to treat the underserved.

Reassessing the NTCTCS Staging Systems for Differentiated Thyroid Cancer, Including Age at Diagnosis

PubMed Central

McLeod, Donald S.A.; Jonklaas, Jacqueline; Brierley, James D.; Ain, Kenneth B.; Cooper, David S.; Fein, Henry G.; Haugen, Bryan R.; Ladenson, Paul W.; Magner, James; Ross, Douglas S.; Skarulis, Monica C.; Steward, David L.; Xing, Mingzhao; Litofsky, Danielle R.; Maxon, Harry R.

2015-01-01

Background: Thyroid cancer is unique for having age as a staging variable. Recently, the commonly used age cut-point of 45 years has been questioned. Objective: This study assessed alternate staging systems on the outcome of overall survival, and compared these with current National Thyroid Cancer Treatment Cooperative Study (NTCTCS) staging systems for papillary and follicular thyroid cancer. Methods: A total of 4721 patients with differentiated thyroid cancer were assessed. Five potential alternate staging systems were generated at age cut-points in five-year increments from 35 to 70 years, and tested for model discrimination (Harrell's C-statistic) and calibration (R2). The best five models for papillary and follicular cancer were further tested with bootstrap resampling and significance testing for discrimination. Results: The best five alternate papillary cancer systems had age cut-points of 45–50 years, with the highest scoring model using 50 years. No significant difference in C-statistic was found between the best alternate and current NTCTCS systems (p = 0.200). The best five alternate follicular cancer systems had age cut-points of 50–55 years, with the highest scoring model using 50 years. All five best alternate staging systems performed better compared with the current system (p = 0.003–0.035). There was no significant difference in discrimination between the best alternate system (cut-point age 50 years) and the best system of cut-point age 45 years (p = 0.197). Conclusions: No alternate papillary cancer systems assessed were significantly better than the current system. New alternate staging systems for follicular cancer appear to be better than the current NTCTCS system, although they require external validation. PMID:26203804

Should All Patients Be Included in Alternative Payment Models for Primary Total Hip Arthroplasty and Total Knee Arthroplasty?

PubMed

Rozell, Joshua C; Courtney, Paul M; Dattilo, Jonathan R; Wu, Chia H; Lee, Gwo-Chin

2016-09-01

Alternative payment models in total joint replacement incentivize cost effective health care delivery and reward reductions in length of stay (LOS), complications, and readmissions. If not adjusted for patient comorbidities, they may encourage restrictive access to health care. We prospectively evaluated 802 consecutive primary total hip arthroplasty and total knee arthroplasty patients evaluating comorbidities associated with increased LOS and readmissions. During this 9-month period, 115 patients (14.3%) required hospitalization >3 days and 16 (1.99%) were readmitted within 90 days. Univariate analysis demonstrated that preoperative narcotic use, heart failure, stroke, chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), and liver disease were more likely to require hospitalization >3 days. In multivariate analysis, CKD and COPD were independent risk factors for LOS >3 days. A Charlson comorbidity index >5 points was associated with increased LOS and readmissions. Patients with CKD, COPD, and Charlson comorbidity index >5 points should not be included in alternative payment model for THA and TKA. Copyright © 2016 Elsevier Inc. All rights reserved.

Endangered species toxicity extrapolation using ICE models

EPA Science Inventory

The National Research Council’s (NRC) report on assessing pesticide risks to threatened and endangered species (T&E) included the recommendation of using interspecies correlation models (ICE) as an alternative to general safety factors for extrapolating across species. ...

Outcome modelling strategies in epidemiology: traditional methods and basic alternatives

PubMed Central

Greenland, Sander; Daniel, Rhian; Pearce, Neil

2016-01-01

Abstract Controlling for too many potential confounders can lead to or aggravate problems of data sparsity or multicollinearity, particularly when the number of covariates is large in relation to the study size. As a result, methods to reduce the number of modelled covariates are often deployed. We review several traditional modelling strategies, including stepwise regression and the ‘change-in-estimate’ (CIE) approach to deciding which potential confounders to include in an outcome-regression model for estimating effects of a targeted exposure. We discuss their shortcomings, and then provide some basic alternatives and refinements that do not require special macros or programming. Throughout, we assume the main goal is to derive the most accurate effect estimates obtainable from the data and commercial software. Allowing that most users must stay within standard software packages, this goal can be roughly approximated using basic methods to assess, and thereby minimize, mean squared error (MSE). PMID:27097747

Models for Rational Decision Making. Analysis of Literature and Selected Bibliography. Analysis and Bibliography Series, No. 6.

ERIC Educational Resources Information Center

Hall, John S.

This review analyzes the trend in educational decision making to replace hierarchical authority structures with more rational models for decision making drawn from management science. Emphasis is also placed on alternatives to a hierarchical decision-making model, including governing models, union models, and influence models. A 54-item…

Characteristics of Students in Traditional versus Alternative High Schools: A Cross-Sectional Analysis of Enrollment in One Urban District

ERIC Educational Resources Information Center

Perzigian, Aaron B.; Afacan, Kemal; Justin, Whitney; Wilkerson, Kimber L.

2017-01-01

Urban school districts are comprised of many diverse high school environments including comprehensive neighborhood schools as well as a variety of smaller alternative models that focus on innovative practices, behavior remediation, or academic recovery. In terms of enrollment distribution, urban school districts are increasingly offering…

Alternatives to an elementary Higgs

NASA Astrophysics Data System (ADS)

Csáki, Csaba; Grojean, Christophe; Terning, John

2016-10-01

Strongly coupled and extra-dimensional models of electroweak symmetry breaking are reviewed. Models examined include warped extra dimensions, bulk Higgs, "little" Higgs, dilaton Higgs, composite Higgs, twin Higgs, quantum critical Higgs, and "fat" SUSY Higgs. Also discussed are current bounds and future LHC searches for this class of models.

Variation at work: alternations between physically and mentally demanding tasks in blue-collar occupations.

PubMed

Jahncke, Helena; Hygge, Staffan; Mathiassen, Svend Erik; Hallman, David; Mixter, Susanna; Lyskov, Eugene

2017-09-01

The aims of this questionnaire study were to describe the occurrence and desired number of alternations between mental and physical tasks in industrial and non-industrial blue-collar work, and determine to which extent selected personal and occupational factors influence these conditions. On average, the 122 participating workers (55 females) reported to have close to four alternations per day between mental and physical tasks, and to desire more alternations than they actually had. They also expressed a general preference for performing a physical task after a mental task and vice versa. In univariate regression models, the desired change in task alternations was significantly associated with gender, age, occupation, years with current work tasks and perceived job control, while occupation was the only significant determinant in a multiple regression model including all factors. Our results suggest that alternations between productive physical and mental tasks could be a viable option in future job rotation. Practitioner Summary: We addressed attitudes among blue-collar workers to alternations between physically and mentally demanding tasks. More alternations were desired than those occurring in the job, and workers preferred performing a physical task after a mental and vice versa. Alternating physical and mental tasks could, thus, be a viable option in job rotation.

Economic analysis of recycling contaminated concrete

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephen, A.; Ayers, K.W.; Boren, J.K.

1997-02-01

Decontamination and Decommissioning activities in the DOE complex generate large volumes of radioactively contaminated and uncontaminated concrete. Currently, this concrete is usually decontaminated, the contaminated waste is disposed of in a LLW facility and the decontaminated concrete is placed in C&D landfills. A number of alternatives to this practice are available including recycling of the concrete. Cost estimates for six alternatives were developed using a spreadsheet model. The results of this analysis show that recycling alternatives are at least as economical as current practice.

On the Suitability of MPI as a PGAS Runtime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daily, Jeffrey A.; Vishnu, Abhinav; Palmer, Bruce J.

2014-12-18

Partitioned Global Address Space (PGAS) models are emerging as a popular alternative to MPI models for designing scalable applications. At the same time, MPI remains a ubiquitous communication subsystem due to its standardization, high performance, and availability on leading platforms. In this paper, we explore the suitability of using MPI as a scalable PGAS communication subsystem. We focus on the Remote Memory Access (RMA) communication in PGAS models which typically includes {\\em get, put,} and {\\em atomic memory operations}. We perform an in-depth exploration of design alternatives based on MPI. These alternatives include using a semantically-matching interface such as MPI-RMA,more » as well as not-so-intuitive interfaces such as MPI two-sided with a combination of multi-threading and dynamic process management. With an in-depth exploration of these alternatives and their shortcomings, we propose a novel design which is facilitated by the data-centric view in PGAS models. This design leverages a combination of highly tuned MPI two-sided semantics and an automatic, user-transparent split of MPI communicators to provide asynchronous progress. We implement the asynchronous progress ranks approach and other approaches within the Communication Runtime for Exascale which is a communication subsystem for Global Arrays. Our performance evaluation spans pure communication benchmarks, graph community detection and sparse matrix-vector multiplication kernels, and a computational chemistry application. The utility of our proposed PR-based approach is demonstrated by a 2.17x speed-up on 1008 processors over the other MPI-based designs.« less

Recommendation for a non-animal alternative to rat caries testing.

PubMed

Featherstone, John D B; Stookey, George K; Kaminski, Michael A; Faller, Robert V

2011-10-01

As a requirement of the Food & Drug Administration's final monograph on "Anticaries drug products for over-the-counter human use", the toothpaste industry has been conducting animal caries tests on every fluoride-containing toothpaste introduced into the U.S. market since 1996. The practice of testing in animals, although required by law, is in stark conflict with the corporate policy of many U.S. and global toothpaste manufacturers, in which, if possible, alternatives to animal testing are utilized. A provision does exist within the regulation which allows the use of an alternative method to demonstrate efficacy. However, to take advantage of this provision, a petition must be submitted to the FDA and in this petition data demonstrating the alternative provides results of "equivalent accuracy" must be included. After many years of research, model development and model comparisons, we have identified one particular laboratory model that demonstrated excellent correlation with the currently accepted animal caries models. This model, known as the Featherstone pH cycling model, is discussed in this paper. The Featherstone pH cycling model has been shown to produce results of equivalent accuracy to the animal caries model by: (1) demonstrating a clinically relevant fluoride dose response similar to that shown in the animal caries model (including 1100 ppm F, 250 ppm F and placebo); (2) demonstrating similar results to the animal caries model for clinically proven dentifrice formulations relative to positive and negative controls; (3) demonstrating discriminating ability in strong agreement with the animal caries model for differentiating between a dentifrice formulation with attenuated fluoride activity and a USP standard; and (4) providing a clinically relevant representation of the caries process, as demonstrated by orthodontic banding studies. In addition, the model sufficiently addresses both salivary and abrasive/anticalculus agent interference concerns. For more than 50 years, fluoride has been the first defense in the fight against dental caries. The clinical effectiveness of fluoride is well accepted and documented extensively in the literature. The mechanism through which fluoride provides its benefit is very straightforward and well understood. The proposed laboratory model effectively simulates the effect of the caries process and has been shown to demonstrate equivalent accuracy to animal caries. This indicates that there are strong scientific grounds for the use of this model as an alternative to the animal caries test. Based on the strength of the data and the correlations noted between the two models, we recommend that the scientific community and the toothpaste industry broadly accept the Featherstone laboratory pH cycling model as an appropriate alternative to animal testing, particularly for ionic fluoride based dentifrices.

Scoring from Contests

PubMed Central

Penn, Elizabeth Maggie

2014-01-01

This article presents a new model for scoring alternatives from “contest” outcomes. The model is a generalization of the method of paired comparison to accommodate comparisons between arbitrarily sized sets of alternatives in which outcomes are any division of a fixed prize. Our approach is also applicable to contests between varying quantities of alternatives. We prove that under a reasonable condition on the comparability of alternatives, there exists a unique collection of scores that produces accurate estimates of the overall performance of each alternative and satisfies a well-known axiom regarding choice probabilities. We apply the method to several problems in which varying choice sets and continuous outcomes may create problems for standard scoring methods. These problems include measuring centrality in network data and the scoring of political candidates via a “feeling thermometer.” In the latter case, we also use the method to uncover and solve a potential difficulty with common methods of rescaling thermometer data to account for issues of interpersonal comparability. PMID:24748759

Post-16 Biology--Some Model Approaches?

ERIC Educational Resources Information Center

Lock, Roger

1997-01-01

Outlines alternative approaches to the teaching of difficult concepts in A-level biology which may help student learning by making abstract ideas more concrete and accessible. Examples include models, posters, and poems for illustrating meiosis, mitosis, genetic mutations, and protein synthesis. (DDR)

Alternative pathways to the 1.5 °C target reduce the need for negative emission technologies

NASA Astrophysics Data System (ADS)

van Vuuren, Detlef P.; Stehfest, Elke; Gernaat, David E. H. J.; van den Berg, Maarten; Bijl, David L.; de Boer, Harmen Sytze; Daioglou, Vassilis; Doelman, Jonathan C.; Edelenbosch, Oreane Y.; Harmsen, Mathijs; Hof, Andries F.; van Sluisveld, Mariësse A. E.

2018-05-01

Mitigation scenarios that achieve the ambitious targets included in the Paris Agreement typically rely on greenhouse gas emission reductions combined with net carbon dioxide removal (CDR) from the atmosphere, mostly accomplished through large-scale application of bioenergy with carbon capture and storage, and afforestation. However, CDR strategies face several difficulties such as reliance on underground CO2 storage and competition for land with food production and biodiversity protection. The question arises whether alternative deep mitigation pathways exist. Here, using an integrated assessment model, we explore the impact of alternative pathways that include lifestyle change, additional reduction of non-CO2 greenhouse gases and more rapid electrification of energy demand based on renewable energy. Although these alternatives also face specific difficulties, they are found to significantly reduce the need for CDR, but not fully eliminate it. The alternatives offer a means to diversify transition pathways to meet the Paris Agreement targets, while simultaneously benefiting other sustainability goals.

Integrated Hydrogeological Model of the General Separations Area, Vol. 2, Rev. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

FLACH, GREGORYK.

1999-04-01

The 15 mi2 General Separations Area (GSA) contains more than 35 RCRA and CERCLA waste units, and is the focus of numerous ongoing and anticipated contaminant migration and remedial alternatives studies. To meet the analysis needs of GSA remediation programs, a groundwater flow model of the area based on the FACT code was developed. The model is consistent with detailed characterization and monitoring data through 1996. Model preprocessing has been automated so that future updates and modifications can be performed quickly and efficiently. Most remedial action scenarios can be explicitly simulated, including vertical recirculation wells, vertical barriers, surface caps, pumpingmore » wells at arbitrary locations, specified drawdown within well casings (instead of flowrate), and wetland impacts of remedial actions. The model has a fine scale vertical mesh and heterogeneous conductivity field, and includes the vadose zone. Therefore, the model is well suited to support subsequent contaminant transport simulations. the model can provide a common framework for analyzing groundwater flow, contaminant migration, and remedial alternatives across Environmental Restoration programs within the GSA.« less

77 FR 72511 - Approval, Disapproval and Promulgation of Air Quality Implementation Plans; Arizona; Regional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... Consulting & Research, Inc. (57) The initials RMC mean or refer to Regional Modeling Center. (58) The... whether an alternative test method to the one required in the SIP is acceptable for PM 10. In addition, we..., we allow the use of Method 5 as an alternative to Method 201A/202. In addition, the FIP includes a...

The Biasing Effects of Unmodeled ARMA Time Series Processes on Latent Growth Curve Model Estimates

ERIC Educational Resources Information Center

Sivo, Stephen; Fan, Xitao; Witta, Lea

2005-01-01

The purpose of this study was to evaluate the robustness of estimated growth curve models when there is stationary autocorrelation among manifest variable errors. The results suggest that when, in practice, growth curve models are fitted to longitudinal data, alternative rival hypotheses to consider would include growth models that also specify…

FlexibleSUSY-A spectrum generator generator for supersymmetric models

NASA Astrophysics Data System (ADS)

Athron, Peter; Park, Jae-hyeon; Stöckinger, Dominik; Voigt, Alexander

2015-05-01

We introduce FlexibleSUSY, a Mathematica and C++ package, which generates a fast, precise C++ spectrum generator for any SUSY model specified by the user. The generated code is designed with both speed and modularity in mind, making it easy to adapt and extend with new features. The model is specified by supplying the superpotential, gauge structure and particle content in a SARAH model file; specific boundary conditions e.g. at the GUT, weak or intermediate scales are defined in a separate FlexibleSUSY model file. From these model files, FlexibleSUSY generates C++ code for self-energies, tadpole corrections, renormalization group equations (RGEs) and electroweak symmetry breaking (EWSB) conditions and combines them with numerical routines for solving the RGEs and EWSB conditions simultaneously. The resulting spectrum generator is then able to solve for the spectrum of the model, including loop-corrected pole masses, consistent with user specified boundary conditions. The modular structure of the generated code allows for individual components to be replaced with an alternative if available. FlexibleSUSY has been carefully designed to grow as alternative solvers and calculators are added. Predefined models include the MSSM, NMSSM, E6SSM, USSM, R-symmetric models and models with right-handed neutrinos.

f( R) gravity modifications: from the action to the data

NASA Astrophysics Data System (ADS)

Lazkoz, Ruth; Ortiz-Baños, María; Salzano, Vincenzo

2018-03-01

It is a very well established matter nowadays that many modified gravity models can offer a sound alternative to General Relativity for the description of the accelerated expansion of the universe. But it is also equally well known that no clear and sharp discrimination between any alternative theory and the classical one has been found so far. In this work, we attempt at formulating a different approach starting from the general class of f( R) theories as test probes: we try to reformulate f( R) Lagrangian terms as explicit functions of the redshift, i.e., as f( z). In this context, the f( R) setting to the consensus cosmological model, the Λ CDM model, can be written as a polynomial including just a constant and a third-order term. Starting from this result, we propose various different polynomial parameterizations f( z), including new terms which would allow for deviations from Λ CDM, and we thoroughly compare them with observational data. While on the one hand we have found no statistically preference for our proposals (even if some of them are as good as Λ CDM by using Bayesian Evidence comparison), we think that our novel approach could provide a different perspective for the development of new and observationally reliable alternative models of gravity.

IDENTIFICATION OF REGIME SHIFTS IN TIME SERIES USING NEIGHBORHOOD STATISTICS

EPA Science Inventory

The identification of alternative dynamic regimes in ecological systems requires several lines of evidence. Previous work on time series analysis of dynamic regimes includes mainly model-fitting methods. We introduce two methods that do not use models. These approaches use state-...

Corrosion performance of alternative steam generator materials and designs. Volume 2. Posttest examination of a seawater-faulted alternative materials model steam generator. Final report. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krupowicz, J.J.; Scott, D.B.; Fink, G.C.

Corrosion results obtained from the post-test non-destructive and destructive examinations of an alternative materials model steam generator are described in this final report. The model operated under representative thermal and hydraulic and accelerated (high seawater contaminant concentration) steam generator secondary water chemistry conditions. Total exposure consisted of 114 steaming days under all volatile treatment (AVT) chemistry conditions followed by 282 fault steaming days at a 30 ppM chloride concentration in the secondary bulk water. Various support plate and lattice strip support designs incorporated Types 347, 405, 409 and SCR-3 stainless steels; Alloys 600 and 690; and carbon steel. Heat transfermore » tube materials included Alloy 600 in various heat treated conditions, Alloy 690, and Alloy 800. All tubing materials in this test exhibited moderate pitting, primarily in the sludge pile region above the tubesheet.« less

Corrosion performance of alternative steam generator materials and designs. Volume 3. Posttest examination of a freshwater-faulted alternative materials model steam generator. Final report. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krupowicz, J.J.; Scott, D.B.; Rentler, R.M.

Corrosion results obtained from the post-test non-destructive and destructive examinations of an alternative materials model steam generator are described in this final report. The model operated under representative thermal and hydraulic and accelerated (high fresh water contaminant concentration) steam generator secondary water chemistry conditions. Total exposure consisted of 114 steaming days under all volatile treatment (AVT) chemistry conditions followed by 358 fault steaming days at a 40 ppM sulfate concentration in the secondary bulk water. Various support plate and lattice strip support designs incorporated Types 347, 405, 409 and SCR-3 stainless steels; Alloys 600 and 690; and carbon steel. Heatmore » transfer tube materials included Alloy 600 in various heat treated conditions, Alloy 690, and Alloy 800. All tubing materials in this test exhibited significant general corrosion beneath thick surface deposits.« less

A Generalized Radiation Model for Human Mobility: Spatial Scale, Searching Direction and Trip Constraint.

PubMed

Kang, Chaogui; Liu, Yu; Guo, Diansheng; Qin, Kun

2015-01-01

We generalized the recently introduced "radiation model", as an analog to the generalization of the classic "gravity model", to consolidate its nature of universality for modeling diverse mobility systems. By imposing the appropriate scaling exponent λ, normalization factor κ and system constraints including searching direction and trip OD constraint, the generalized radiation model accurately captures real human movements in various scenarios and spatial scales, including two different countries and four different cities. Our analytical results also indicated that the generalized radiation model outperformed alternative mobility models in various empirical analyses.

Women in Management.

ERIC Educational Resources Information Center

Crampton, Suzanne M.; Mishra, Jitendra M.

1999-01-01

Major issues surrounding women in management include the glass ceiling and prevalence of myths and stereotypes. Organizational and individual responses to improve use of the diversity of their skills and talents include mentors, sponsors, role models, networks, alternative schedules, family leave, employee assistance, and child care. (JOW)

75 FR 53371 - Liquefied Natural Gas Facilities: Obtaining Approval of Alternative Vapor-Gas Dispersion Models

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... factors as the approved models, are validated by experimental test data, and receive the Administrator's... stage of the MEP involves applying the model against a database of experimental test cases including..., particularly the requirement for validation by experimental test data. That guidance is based on the MEP's...

The use of neurocomputational models as alternatives to animal models in the development of electrical brain stimulation treatments.

PubMed

Beuter, Anne

2017-05-01

Recent publications call for more animal models to be used and more experiments to be performed, in order to better understand the mechanisms of neurodegenerative disorders, to improve human health, and to develop new brain stimulation treatments. In response to these calls, some limitations of the current animal models are examined by using Deep Brain Stimulation (DBS) in Parkinson's disease as an illustrative example. Without focusing on the arguments for or against animal experimentation, or on the history of DBS, the present paper argues that given recent technological and theoretical advances, the time has come to consider bioinspired computational modelling as a valid alternative to animal models, in order to design the next generation of human brain stimulation treatments. However, before computational neuroscience is fully integrated in the translational process and used as a substitute for animal models, several obstacles need to be overcome. These obstacles are examined in the context of institutional, financial, technological and behavioural lock-in. Recommendations include encouraging agreement to change long-term habitual practices, explaining what alternative models can achieve, considering economic stakes, simplifying administrative and regulatory constraints, and carefully examining possible conflicts of interest. 2017 FRAME.

Space platform power system hardware testbed

NASA Technical Reports Server (NTRS)

Sable, D.; Patil, A.; Sizemore, T.; Deuty, S.; Noon, J.; Cho, B. H.; Lee, F. C.

1991-01-01

The scope of the work on the NASA Space Platform includes the design of a multi-module, multi-phase boost regulator, and a voltage-fed, push-pull autotransformer converter for the battery discharger. A buck converter was designed for the charge regulator. Also included is the associated mode control electronics for the charger and discharger, as well as continued development of a comprehensive modeling and simulation tool for the system. The design of the multi-module boost converter is discussed for use as a battery discharger. An alternative battery discharger design is discussed using a voltage-fed, push-pull autotransformer converter. The design of the charge regulator is explained using a simple buck converter. The design of the mode controller and effects of locating the bus filter capacitor bank 20 feet away from the power ORU are discussed. A brief discussion of some alternative topologies for battery charging and discharging is included. The power system modeling is described.

Development Of Educational Programs In Renewable And Alternative Energy Processing: The Case Of Russia

NASA Astrophysics Data System (ADS)

Svirina, Anna; Shindor, Olga; Tatmyshevsky, Konstantin

2014-12-01

The paper deals with the main problems of Russian energy system development that proves necessary to provide educational programs in the field of renewable and alternative energy. In the paper the process of curricula development and defining teaching techniques on the basis of expert opinion evaluation is defined, and the competence model for renewable and alternative energy processing master students is suggested. On the basis of a distributed questionnaire and in-depth interviews, the data for statistical analysis was obtained. On the basis of this data, an optimization of curricula structure was performed, and three models of a structure for optimizing teaching techniques were developed. The suggested educational program structure which was adopted by employers is presented in the paper. The findings include quantitatively estimated importance of systemic thinking and professional skills and knowledge as basic competences of a masters' program graduate; statistically estimated necessity of practice-based learning approach; and optimization models for structuring curricula in renewable and alternative energy processing. These findings allow the establishment of a platform for the development of educational programs.

A Hydrostratigraphic Model and Alternatives for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 97: Yucca Flat-Climax Mine, Lincoln and Nye Counties, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geotechnical Sciences Group Bechtel Nevada

2006-01-01

A new three-dimensional hydrostratigraphic framework model for the Yucca Flat-Climax Mine Corrective Action Unit was completed in 2005. The model area includes Yucca Flat and Climax Mine, former nuclear testing areas at the Nevada Test Site, and proximal areas. The model area is approximately 1,250 square kilometers in size and is geologically complex. Yucca Flat is a topographically closed basin typical of many valleys in the Basin and Range province. Faulted and tilted blocks of Tertiary-age volcanic rocks and underlying Proterozoic and Paleozoic sedimentary rocks form low ranges around the structural basin. During the Cretaceous Period a granitic intrusive wasmore » emplaced at the north end of Yucca Flat. A diverse set of geological and geophysical data collected over the past 50 years was used to develop a structural model and hydrostratigraphic system for the basin. These were integrated using EarthVision? software to develop the 3-dimensional hydrostratigraphic framework model. Fifty-six stratigraphic units in the model area were grouped into 25 hydrostratigraphic units based on each unit's propensity toward aquifer or aquitard characteristics. The authors organized the alluvial section into 3 hydrostratigraphic units including 2 aquifers and 1 confining unit. The volcanic units in the model area are organized into 13 hydrostratigraphic units that include 8 aquifers and 5 confining units. The underlying pre-Tertiary rocks are divided into 7 hydrostratigraphic units, including 3 aquifers and 4 confining units. Other units include 1 Tertiary-age sedimentary confining unit and 1 Mesozoic-age granitic confining unit. The model depicts the thickness, extent, and geometric relationships of these hydrostratigraphic units (''layers'' in the model) along with the major structural features (i.e., faults). The model incorporates 178 high-angle normal faults of Tertiary age and 2 low-angle thrust faults of Mesozoic age. The complexity of the model area and the non-uniqueness of some of the interpretations incorporated into the base model made it necessary to formulate alternative interpretations for some of the major features in the model. Five of these alternatives were developed so they could be modeled in the same fashion as the base model. This work was done for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Underground Test Area subproject of the Environmental Restoration Project.« less

Representing Carbon Capture and Storage in MARKAL EPAUS9r16a

EPA Science Inventory

Energy system models are used to evaluate the energy and environmental implications of alternative pathways for producing and using energy. Many such models include representations of the costs and capacities of carbon capture and sequestration (CCS). In this presentation, Dan Lo...

COMBINING SOURCES IN STABLE ISOTOPE MIXING MODELS: ALTERNATIVE METHODS

EPA Science Inventory

Stable isotope mixing models are often used to quantify source contributions to a mixture. Examples include pollution source identification; trophic web studies; analysis of water sources for soils, plants, or water bodies; and many others. A common problem is having too many s...

Pricing Models and Payment Schemes for Library Collections.

ERIC Educational Resources Information Center

Stern, David

2002-01-01

Discusses new pricing and payment options for libraries in light of online products. Topics include alternative cost models rather than traditional subscriptions; use-based pricing; changes in scholarly communication due to information technology; methods to determine appropriate charges for different organizations; consortial plans; funding; and…

The Multiple Component Alternative for Gifted Education.

ERIC Educational Resources Information Center

Swassing, Ray

1984-01-01

The Multiple Component Model (MCM) of gifted education includes instruction which may overlap in literature, history, art, enrichment, languages, science, physics, math, music, and dance. The model rests on multifactored identification and requires systematic development and selection of components with ongoing feedback and evaluation. (CL)

An empirical model for estimating annual consumption by freshwater fish populations

USGS Publications Warehouse

Liao, H.; Pierce, C.L.; Larscheid, J.G.

2005-01-01

Population consumption is an important process linking predator populations to their prey resources. Simple tools are needed to enable fisheries managers to estimate population consumption. We assembled 74 individual estimates of annual consumption by freshwater fish populations and their mean annual population size, 41 of which also included estimates of mean annual biomass. The data set included 14 freshwater fish species from 10 different bodies of water. From this data set we developed two simple linear regression models predicting annual population consumption. Log-transformed population size explained 94% of the variation in log-transformed annual population consumption. Log-transformed biomass explained 98% of the variation in log-transformed annual population consumption. We quantified the accuracy of our regressions and three alternative consumption models as the mean percent difference from observed (bioenergetics-derived) estimates in a test data set. Predictions from our population-size regression matched observed consumption estimates poorly (mean percent difference = 222%). Predictions from our biomass regression matched observed consumption reasonably well (mean percent difference = 24%). The biomass regression was superior to an alternative model, similar in complexity, and comparable to two alternative models that were more complex and difficult to apply. Our biomass regression model, log10(consumption) = 0.5442 + 0.9962??log10(biomass), will be a useful tool for fishery managers, enabling them to make reasonably accurate annual population consumption predictions from mean annual biomass estimates. ?? Copyright by the American Fisheries Society 2005.

Using multi-objective robust decision making to support seasonal water management in the Chao Phraya River basin, Thailand

NASA Astrophysics Data System (ADS)

Riegels, Niels; Jessen, Oluf; Madsen, Henrik

2016-04-01

A multi-objective robust decision making approach is demonstrated that supports seasonal water management in the Chao Phraya River basin in Thailand. The approach uses multi-objective optimization to identify a Pareto-optimal set of management alternatives. Ensemble simulation is used to evaluate how each member of the Pareto set performs under a range of uncertain future conditions, and a robustness criterion is used to select a preferred alternative. Data mining tools are then used to identify ranges of uncertain factor values that lead to unacceptable performance for the preferred alternative. The approach is compared to a multi-criteria scenario analysis approach to estimate whether the introduction of additional complexity has the potential to improve decision making. Dry season irrigation in Thailand is managed through non-binding recommendations about the maximum extent of rice cultivation along with incentives for less water-intensive crops. Management authorities lack authority to prevent river withdrawals for irrigation when rice cultivation exceeds recommendations. In practice, this means that water must be provided to irrigate the actual planted area because of downstream municipal water supply requirements and water quality constraints. This results in dry season reservoir withdrawals that exceed planned withdrawals, reducing carryover storage to hedge against insufficient wet season runoff. The dry season planning problem in Thailand can therefore be framed in terms of decisions, objectives, constraints, and uncertainties. Decisions include recommendations about the maximum extent of rice cultivation and incentives for growing less water-intensive crops. Objectives are to maximize benefits to farmers, minimize the risk of inadequate carryover storage, and minimize incentives. Constraints include downstream municipal demands and water quality requirements. Uncertainties include the actual extent of rice cultivation, dry season precipitation, and precipitation in the following wet season. The multi-objective robust decision making approach is implemented as follows. First, three baseline simulation models are developed, including a crop water demand model, a river basin simulation model, and model of the impact of incentives on cropping patterns. The crop water demand model estimates irrigation water demands; the river basin simulation model estimates reservoir drawdown required to meet demands given forecasts of precipitation, evaporation, and runoff; the model of incentive impacts estimates the cost of incentives as function of marginal changes in rice yields. Optimization is used to find a set of non-dominated alternatives as a function of rice area and incentive decisions. An ensemble of uncertain model inputs is generated to represent uncertain hydrological and crop area forecasts. An ensemble of indicator values is then generated for each of the decision objectives: farmer benefits, end-of-wet-season reservoir storage, and the cost of incentives. A single alternative is selected from the Pareto set using a robustness criterion. Threshold values are defined for each of the objectives to identify ensemble members for which objective values are unacceptable, and the PRIM data mining algorithm is then used to identify input values associated with unacceptable model outcomes.

MMA, A Computer Code for Multi-Model Analysis

USGS Publications Warehouse

Poeter, Eileen P.; Hill, Mary C.

2007-01-01

This report documents the Multi-Model Analysis (MMA) computer code. MMA can be used to evaluate results from alternative models of a single system using the same set of observations for all models. As long as the observations, the observation weighting, and system being represented are the same, the models can differ in nearly any way imaginable. For example, they may include different processes, different simulation software, different temporal definitions (for example, steady-state and transient models could be considered), and so on. The multiple models need to be calibrated by nonlinear regression. Calibration of the individual models needs to be completed before application of MMA. MMA can be used to rank models and calculate posterior model probabilities. These can be used to (1) determine the relative importance of the characteristics embodied in the alternative models, (2) calculate model-averaged parameter estimates and predictions, and (3) quantify the uncertainty of parameter estimates and predictions in a way that integrates the variations represented by the alternative models. There is a lack of consensus on what model analysis methods are best, so MMA provides four default methods. Two are based on Kullback-Leibler information, and use the AIC (Akaike Information Criterion) or AICc (second-order-bias-corrected AIC) model discrimination criteria. The other two default methods are the BIC (Bayesian Information Criterion) and the KIC (Kashyap Information Criterion) model discrimination criteria. Use of the KIC criterion is equivalent to using the maximum-likelihood Bayesian model averaging (MLBMA) method. AIC, AICc, and BIC can be derived from Frequentist or Bayesian arguments. The default methods based on Kullback-Leibler information have a number of theoretical advantages, including that they tend to favor more complicated models as more data become available than do the other methods, which makes sense in many situations. Many applications of MMA will be well served by the default methods provided. To use the default methods, the only required input for MMA is a list of directories where the files for the alternate models are located. Evaluation and development of model-analysis methods are active areas of research. To facilitate exploration and innovation, MMA allows the user broad discretion to define alternatives to the default procedures. For example, MMA allows the user to (a) rank models based on model criteria defined using a wide range of provided and user-defined statistics in addition to the default AIC, AICc, BIC, and KIC criteria, (b) create their own criteria using model measures available from the code, and (c) define how each model criterion is used to calculate related posterior model probabilities. The default model criteria rate models are based on model fit to observations, the number of observations and estimated parameters, and, for KIC, the Fisher information matrix. In addition, MMA allows the analysis to include an evaluation of estimated parameter values. This is accomplished by allowing the user to define unreasonable estimated parameter values or relative estimated parameter values. An example of the latter is that it may be expected that one parameter value will be less than another, as might be the case if two parameters represented the hydraulic conductivity of distinct materials such as fine and coarse sand. Models with parameter values that violate the user-defined conditions are excluded from further consideration by MMA. Ground-water models are used as examples in this report, but MMA can be used to evaluate any set of models for which the required files have been produced. MMA needs to read files from a separate directory for each alternative model considered. The needed files are produced when using the Sensitivity-Analysis or Parameter-Estimation mode of UCODE_2005, or, possibly, the equivalent capability of another program. MMA is constructed using

Update to core reporting practices in structural equation modeling.

PubMed

Schreiber, James B

This paper is a technical update to "Core Reporting Practices in Structural Equation Modeling." 1 As such, the content covered in this paper includes, sample size, missing data, specification and identification of models, estimation method choices, fit and residual concerns, nested, alternative, and equivalent models, and unique issues within the SEM family of techniques. Copyright © 2016 Elsevier Inc. All rights reserved.

Computer program for Stirling engine performance calculations

NASA Technical Reports Server (NTRS)

Tew, R. C., Jr.

1983-01-01

The thermodynamic characteristics of the Stirling engine were analyzed and modeled on a computer to support its development as a possible alternative to the automobile spark ignition engine. The computer model is documented. The documentation includes a user's manual, symbols list, a test case, comparison of model predictions with test results, and a description of the analytical equations used in the model.

A call to improve methods for estimating tree biomass for regional and national assessments

Treesearch

Aaron R. Weiskittel; David W. MacFarlane; Philip J. Radtke; David L.R. Affleck; Hailemariam Temesgen; Christopher W. Woodall; James A. Westfall; John W. Coulston

2015-01-01

Tree biomass is typically estimated using statistical models. This review highlights five limitations of most tree biomass models, which include the following: (1) biomass data are costly to collect and alternative sampling methods are used; (2) belowground data and models are generally lacking; (3) models are often developed from small and geographically limited data...

Broad-band High-Frequency Sound Interaction With the Seafloor

DTIC Science & Technology

1998-01-01

interface, propagation within and scattering from the seafloor. OBJECTIVES Resolution of modeling issues through experimental measurement of acoustic ...approximation, particularly the roughness scattering mechanism for propagating and evanescent waves, offer alternative models of the observed acoustic ...applicability of each model and it’s relative merits. The candidate models of acoustic penetration include: 1. Biot slow wave 2. Scattering of in-water

77 FR 74616 - Amendments and Correction to Petitions for Waiver and Interim Waiver for Consumer Products and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

... decision and order must be used for all future testing for any basic models covered by the decision and... require petitioners to: (1) Specify the basic model(s) to which the waiver applies; (2) identify other manufacturers of similar products; (3) include any known alternate test procedures of the basic model, with the...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gehrmann, Thies; Pelkmans, Jordi F.; Lugones, Luis G.

Recent genome-wide studies have demonstrated that fungi possess the machinery to alternatively splice pre-mRNA. However, there has not been a systematic categorization of the functional impact of alternative splicing in a fungus. We investigate alternative splicing and its functional consequences in the model mushroom forming fungus Schizophyllum commune. Alternative splicing was demonstrated for 2,285 out of 12,988 expressed genes, resulting in 20% additional transcripts. Intron retentions were the most common alternative splicing events, accounting for 33% of all splicing events, and 43% of the events in coding regions. On the other hand, exon skipping events were rare in coding regionsmore » (1%) but enriched in UTRs where they accounted for 57% of the events. Specific functional groups, including transcription factors, contained alternatively spliced genes. Alternatively spliced transcripts were regulated differently throughout development in 19% of the 2,285 alternatively spliced genes. Notably, 69% of alternatively spliced genes have predicted alternative functionality by loss or gain of functional domains, or by acquiring alternative subcellular locations. S. commune exhibits more alternative splicing than any other studied fungus. Finally, taken together, alternative splicing increases the complexity of the S. commune proteome considerably and provides it with a rich repertoire of alternative functionality that is exploited dynamically.« less

Multi-model inference for incorporating trophic and climate uncertainty into stock assessments

NASA Astrophysics Data System (ADS)

Ianelli, James; Holsman, Kirstin K.; Punt, André E.; Aydin, Kerim

2016-12-01

Ecosystem-based fisheries management (EBFM) approaches allow a broader and more extensive consideration of objectives than is typically possible with conventional single-species approaches. Ecosystem linkages may include trophic interactions and climate change effects on productivity for the relevant species within the system. Presently, models are evolving to include a comprehensive set of fishery and ecosystem information to address these broader management considerations. The increased scope of EBFM approaches is accompanied with a greater number of plausible models to describe the systems. This can lead to harvest recommendations and biological reference points that differ considerably among models. Model selection for projections (and specific catch recommendations) often occurs through a process that tends to adopt familiar, often simpler, models without considering those that incorporate more complex ecosystem information. Multi-model inference provides a framework that resolves this dilemma by providing a means of including information from alternative, often divergent models to inform biological reference points and possible catch consequences. We apply an example of this approach to data for three species of groundfish in the Bering Sea: walleye pollock, Pacific cod, and arrowtooth flounder using three models: 1) an age-structured "conventional" single-species model, 2) an age-structured single-species model with temperature-specific weight at age, and 3) a temperature-specific multi-species stock assessment model. The latter two approaches also include consideration of alternative future climate scenarios, adding another dimension to evaluate model projection uncertainty. We show how Bayesian model-averaging methods can be used to incorporate such trophic and climate information to broaden single-species stock assessments by using an EBFM approach that may better characterize uncertainty.

Developing models that analyze the economic/environmental trade-offs implicit in water resource management

NASA Astrophysics Data System (ADS)

Howitt, R. E.

2016-12-01

Hydro-economic models have been used to analyze optimal supply management and groundwater use for the past 25 years. They are characterized by an objective function that usually maximizes economic measures such as consumer and producer surplus subject to hydrologic equations of motion or water distribution systems. The hydrologic and economic components are sometimes fully integrated. Alternatively they may use an iterative interactive process. Environmental considerations have been included in hydro-economic models as inequality constraints. Representing environmental requirements as constraints is a rigid approximation of the range of management alternatives that could be used to implement environmental objectives. The next generation of hydro-economic models, currently being developed, require that the environmental alternatives be represented by continuous or semi-continuous functions which relate water resource use allocated to the environment with the probabilities of achieving environmental objectives. These functions will be generated by process models of environmental and biological systems which are now advanced to the state that they can realistically represent environmental systems and flexibility to interact with economic models. Examples are crop growth models, climate modeling, and biological models of forest, fish, and fauna systems. These process models can represent environmental outcomes in a form that is similar to economic production functions. When combined with economic models the interacting process models can reproduce a range of trade-offs between economic and environmental objectives, and thus optimize social value of many water and environmental resources. Some examples of this next-generation of hydro-enviro- economic models are reviewed. In these models implicit production functions for environmental goods are combined with hydrologic equations of motion and economic response functions. We discuss models that show interaction between environmental goods and agricultural production, and others that address alternative climate change policies, or habitat provision.

Pathways Between Marriage and Parenting for Wives and Husbands: The Role of Coparenting1

PubMed Central

Morrill, Melinda

2016-01-01

As family systems research has expanded, so have investigations into how marital partners coparent together. Although coparenting research has increasingly found support for the influential role of coparenting on both marital relationships and parenting practices, coparenting has traditionally been investigated as part of an indirect system which begins with marital health, is mediated by coparenting processes, and then culminates in each partner's parenting. The field has not tested how this traditional model compares to the equally plausible alternative model in which coparenting simultaneously predicts both marital relationships and parenting practices. Furthermore, statistical and practical limitations have typically resulted in only one parent being analyzed in these models. This study used model-fitting analyses to include both wives and husbands in a test of these two alternative models of the role of coparenting in the family system. Our data suggested that both the traditional indirect model (marital health to coparenting to parenting practices), and the alternative predictor model where coparenting alliance directly and simultaneously predicts marital health and parenting practices, fit for both spouses. This suggests that dynamic and multiple roles may be played by coparenting in the overall family system, and raises important practical implications for family clinicians. PMID:20377635

Development and Integration of an Advanced Stirling Convertor Linear Alternator Model for a Tool Simulating Convertor Performance and Creating Phasor Diagrams

NASA Technical Reports Server (NTRS)

Metscher, Jonathan F.; Lewandowski, Edward J.

2013-01-01

A simple model of the Advanced Stirling Convertors (ASC) linear alternator and an AC bus controller has been developed and combined with a previously developed thermodynamic model of the convertor for a more complete simulation and analysis of the system performance. The model was developed using Sage, a 1-D thermodynamic modeling program that now includes electro-magnetic components. The convertor, consisting of a free-piston Stirling engine combined with a linear alternator, has sufficiently sinusoidal steady-state behavior to allow for phasor analysis of the forces and voltages acting in the system. A MATLAB graphical user interface (GUI) has been developed to interface with the Sage software for simplified use of the ASC model, calculation of forces, and automated creation of phasor diagrams. The GUI allows the user to vary convertor parameters while fixing different input or output parameters and observe the effect on the phasor diagrams or system performance. The new ASC model and GUI help create a better understanding of the relationship between the electrical component voltages and mechanical forces. This allows better insight into the overall convertor dynamics and performance.

An ``Alternating-Curvature'' Model for the Nanometer-scale Structure of the Nafion Ionomer, Based on Backbone Properties Detected by NMR

NASA Astrophysics Data System (ADS)

Schmidt-Rohr, Klaus; Chen, Q.

2006-03-01

The perfluorinated ionomer, Nafion, which consists of a (-CF2-)n backbone and charged side branches, is useful as a proton exchange membrane in H2/O2 fuel cells. A modified model of the nanometer-scale structure of hydrated Nafion will be presented. It features hydrated ionic clusters familiar from some previous models, but is based most prominently on pronounced backbone rigidity between branch points and limited orientational correlation of local chain axes. These features have been revealed by solid-state NMR measurements, which take advantage of fast rotations of the backbones around their local axes. The resulting alternating curvature of the backbones towards the hydrated clusters also better satisfies the requirement of dense space filling in solids. Simulations based on this ``alternating curvature'' model reproduce orientational correlation data from NMR, as well as scattering features such as the ionomer peak and the I(q) ˜ 1/q power law at small q values, which can be attributed to modulated cylinders resulting from the chain stiffness. The shortcomings of previous models, including Gierke's cluster model and more recent lamellar or bundle models, in matching all requirements imposed by the experimental data will be discussed.

Multi-criteria evaluation of wastewater treatment plant control strategies under uncertainty.

PubMed

Flores-Alsina, Xavier; Rodríguez-Roda, Ignasi; Sin, Gürkan; Gernaey, Krist V

2008-11-01

The evaluation of activated sludge control strategies in wastewater treatment plants (WWTP) via mathematical modelling is a complex activity because several objectives; e.g. economic, environmental, technical and legal; must be taken into account at the same time, i.e. the evaluation of the alternatives is a multi-criteria problem. Activated sludge models are not well characterized and some of the parameters can present uncertainty, e.g. the influent fractions arriving to the facility and the effect of either temperature or toxic compounds on the kinetic parameters, having a strong influence in the model predictions used during the evaluation of the alternatives and affecting the resulting rank of preferences. Using a simplified version of the IWA Benchmark Simulation Model No. 2 as a case study, this article shows the variations in the decision making when the uncertainty in activated sludge model (ASM) parameters is either included or not during the evaluation of WWTP control strategies. This paper comprises two main sections. Firstly, there is the evaluation of six WWTP control strategies using multi-criteria decision analysis setting the ASM parameters at their default value. In the following section, the uncertainty is introduced, i.e. input uncertainty, which is characterized by probability distribution functions based on the available process knowledge. Next, Monte Carlo simulations are run to propagate input through the model and affect the different outcomes. Thus (i) the variation in the overall degree of satisfaction of the control objectives for the generated WWTP control strategies is quantified, (ii) the contributions of environmental, legal, technical and economic objectives to the existing variance are identified and finally (iii) the influence of the relative importance of the control objectives during the selection of alternatives is analyzed. The results show that the control strategies with an external carbon source reduce the output uncertainty in the criteria used to quantify the degree of satisfaction of environmental, technical and legal objectives, but increasing the economical costs and their variability as a trade-off. Also, it is shown how a preliminary selected alternative with cascade ammonium controller becomes less desirable when input uncertainty is included, having simpler alternatives more chance of success.

Preparation of Term Papers Based upon a Research-Process Model.

ERIC Educational Resources Information Center

Feldmann, Rodney Mansfield; Schloman, Barbara Frick

1990-01-01

Described is an alternative method of term paper preparation which provides a step-by-step sequence of assignments and provides feedback to the students at all stages in the preparation of the report. An example of this model is provided including 13 sequential assignments. (CW)

Development of a Value Inquiry Model in Biology Education.

ERIC Educational Resources Information Center

Jeong, Eun-Young; Kim, Young-Soo

2000-01-01

Points out the rapid advances in biology, increasing bioethical issues, and how students need to make rational decisions. Introduces a value inquiry model development that includes identifying and clarifying value problems; understanding biological knowledge related to conflict situations; considering, selecting, and evaluating each alternative;…

Snacks, beverages, vending machines, and school stores: a comparison of alternative and regular schools in Minnesota, 2002 to 2008.

PubMed

Kubik, Martha Y; Davey, Cynthia; MacLehose, Richard F; Coombes, Brandon; Nanney, Marilyn S

2015-01-01

In US secondary schools, vending machines and school stores are a common source of low-nutrient, energy-dense snacks and beverages, including sugar-sweetened beverages, high-fat salty snacks, and candy. However, little is known about the prevalence of these food practices in alternative schools, which are educational settings for students at risk of academic failure due to truancy, school expulsion, and behavior problems. Nationwide, more than 5,000 alternative schools enroll about one-half million students who are disproportionately minority and low-income youth. Principal survey data from a cross-sectional sample of alternative (n=104) and regular (n=339) schools collected biennially from 2002-2008 as part of the Centers for Disease Control and Prevention Minnesota School Health Profiles were used to assess and compare food practice prevalence over time. Generalized estimating equation models were used to estimate prevalence, adjusting for school demographics. Over time, food practice prevalence decreased significantly for both alternative and regular schools, although declines were mostly modest. However, the decrease in high-fat, salty snacks was significantly less for alternative than regular schools (-22.9% vs -42.2%; P<0.0001). Efforts to improve access to healthy food choices at school should reach all schools, including alternative schools. Study findings suggest high-fat salty snacks are more common in vending machines and school stores in alternative schools than regular schools, which may contribute to increased snacking behavior among students and extra consumption of salt, fat, and sugar. Study findings support the need to include alternative schools in future efforts that aim to reform the school food environment. Copyright © 2015 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

Snacks, beverages, vending machines and school stores: A comparison of alternative and regular schools in Minnesota, 2002 to 2008

PubMed Central

Davey, Cynthia; MacLehose, Richard F.; Coombes, Brandon; Nanney, Marilyn S.

2014-01-01

In US secondary schools, vending machines and school stores are a common source of low-nutrient, energy-dense snacks and beverages, including sugar-sweetened beverages, high fat salty snacks and candy. However, little is known about the prevalence of these food practices in alternative schools, educational settings for students at risk of academic failure due to truancy, school expulsion and behavioral problems. Nationwide, over 5000 alternative schools enroll about one-half million students, who are disproportionately minority and low-income youth. Principal survey data from a cross-sectional sample of alternative (n=104) and regular (n=339) schools collected biennially from 2002–2008 as part of the Centers for Disease Control and Prevention Minnesota School Health Profiles were used to assess and compare food practice prevalence over time. Generalized estimating equation models were used to estimate prevalence, adjusting for school demographics. Over time, food practice prevalence decreased significantly for both alternative and regular schools, although declines were mostly modest. However, the decrease in high fat, salty snacks was significantly less for alternative than regular schools (−22.9% versus −42.2%; p<0.0001). Efforts to improve access to healthy food choice at school should reach all schools, including alternative schools. Study findings suggest high fat salty snacks are more common in vending machines and school stores in alternative schools than regular schools, which may contribute to increased snacking behavior among students and extra consumption of salt, fat and sugar. Study findings support the need to include alternative schools in future efforts that aim to reform the school food environment. PMID:25132120

Utilizing interview and self-report assessment of the Five-Factor Model to examine convergence with the alternative model for personality disorders.

PubMed

Helle, Ashley C; Trull, Timothy J; Widiger, Thomas A; Mullins-Sweatt, Stephanie N

2017-07-01

An alternative model for personality disorders is included in Section III (Emerging Models and Measures) of Diagnostic and Statistical Manual of Mental Disorders, (5th ed.; DSM-5). The DSM-5 dimensional trait model is an extension of the Five-Factor Model (FFM; American Psychiatric Association, 2013). The Personality Inventory for DSM-5 (PID-5) assesses the 5 domains and 25 traits in the alternative model. The current study expands on recent research to examine the relationship of the PID-5 with an interview measure of the FFM. The Structured Interview for the Five Factor Model of Personality (SIFFM) assesses the 5 bipolar domains and 30 facets of the FFM. Research has indicated that the SIFFM captures maladaptive aspects of personality (as well as adaptive). The SIFFM, NEO PI-R, and PID-5 were administered to participants to examine their respective convergent and discriminant validity. Results provide evidence for the convergence of the 2 models using self-report and interview measures of the FFM. Clinical implications and future directions are discussed, particularly a call for the development of a structured interview for the assessment of the DSM-5 dimensional trait model. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

An analytical framework to assist decision makers in the use of forest ecosystem model predictions

USGS Publications Warehouse

Larocque, Guy R.; Bhatti, Jagtar S.; Ascough, J.C.; Liu, J.; Luckai, N.; Mailly, D.; Archambault, L.; Gordon, Andrew M.

2011-01-01

The predictions from most forest ecosystem models originate from deterministic simulations. However, few evaluation exercises for model outputs are performed by either model developers or users. This issue has important consequences for decision makers using these models to develop natural resource management policies, as they cannot evaluate the extent to which predictions stemming from the simulation of alternative management scenarios may result in significant environmental or economic differences. Various numerical methods, such as sensitivity/uncertainty analyses, or bootstrap methods, may be used to evaluate models and the errors associated with their outputs. However, the application of each of these methods carries unique challenges which decision makers do not necessarily understand; guidance is required when interpreting the output generated from each model. This paper proposes a decision flow chart in the form of an analytical framework to help decision makers apply, in an orderly fashion, different steps involved in examining the model outputs. The analytical framework is discussed with regard to the definition of problems and objectives and includes the following topics: model selection, identification of alternatives, modelling tasks and selecting alternatives for developing policy or implementing management scenarios. Its application is illustrated using an on-going exercise in developing silvicultural guidelines for a forest management enterprise in Ontario, Canada.

Visualization of Flow Alternatives, Lower Missouri River

USGS Publications Warehouse

Jacobson, Robert B.; Heuser, Jeanne

2002-01-01

Background The U.S. Army Corps of Engineers (COE) 'Missouri River Master Water Control Manual' (Master Manual) review has resulted in consideration of many flow alternatives for managing the water in the river (COE, 2001; 1998a). The purpose of this report is to present flow-management alternative model results in a way that can be easily visualized and understood. This report was updated in October 2001 to focus on the specific flow-management alternatives presented by the COE in the 'Master Manual Revised Draft Environmental Impact Statement' (RDEIS; COE, 2001). The original version (February 2000) is available by clicking here. The COE, U.S. Fish and Wildlife Service (FWS), Missouri River states, and Missouri River basin tribes have been participating in discussions concerning water management of the Missouri River mainstem reservoir system (MRMRS), the Missouri River Bank Stabilization and Navigation Project, and the Kansas River reservoir system since 1986. These discussions include general input to the revision of the Master Manual as well as formal consultation under Section 7 of the Endangered Species Act. In 2000, the FWS issued a Biological Opinion that prescribed changes to reservoir management on the Missouri River that were believed to be necessary to preclude jeopardy to three endangered species, the pallid sturgeon, piping plover, and interior least tern (USFWS, 2000). The combined Missouri River system is large and complex, including many reservoirs, control structures, and free-flowing reaches extending over a broad region. The ability to assess future impacts of altered management scenarios necessarily involves complex, computational models that attempt to integrate physical, chemical, biological, and economic effects. Graphical visualization of the model output is intended to improve understanding of the differences among flow-management alternatives.

Bringing Older Adults into the Classroom: The Sharing Community Model

ERIC Educational Resources Information Center

Hantman, Shira; Oz, Miriam Ben; Gutman, Caroline; Criden, Wendy

2013-01-01

This article describes an innovative model for teaching gerontological social work that has been introduced into the social work methods curriculum in the Department of Social Work at a college in northern Israel. The basic concept of the model is to create an alternative learning environment by including older persons as full participants in the…

Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

PubMed Central

Ramírez-Romero, Rafael; Nevárez-Garza, Alicia M.; Rodríguez-Tovar, Luis E.; Wong-González, Alfredo; Ledezma-Torres, Rogelio A.; Hernández-Vidal, Gustavo

2012-01-01

Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model. PMID:22629176

Advanced analysis technique for the evaluation of linear alternators and linear motors

NASA Technical Reports Server (NTRS)

Holliday, Jeffrey C.

1995-01-01

A method for the mathematical analysis of linear alternator and linear motor devices and designs is described, and an example of its use is included. The technique seeks to surpass other methods of analysis by including more rigorous treatment of phenomena normally omitted or coarsely approximated such as eddy braking, non-linear material properties, and power losses generated within structures surrounding the device. The technique is broadly applicable to linear alternators and linear motors involving iron yoke structures and moving permanent magnets. The technique involves the application of Amperian current equivalents to the modeling of the moving permanent magnet components within a finite element formulation. The resulting steady state and transient mode field solutions can simultaneously account for the moving and static field sources within and around the device.

ALTERNATIVES TO HELIUM-3 FOR NEUTRON MULTIPLICITY DETECTORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ely, James H.; Siciliano, Edward R.; Swinhoe, Martyn T.

Collaboration between the Pacific Northwest National Laboratory (PNNL) and the Los Alamos National Laboratory (LANL) is underway to evaluate neutron detection technologies that might replace the high-pressure helium (3He) tubes currently used in neutron multiplicity counter for safeguards applications. The current stockpile of 3He is diminishing and alternatives are needed for a variety of neutron detection applications including multiplicity counters. The first phase of this investigation uses a series of Monte Carlo calculations to simulate the performance of an existing neutron multiplicity counter configuration by replacing the 3He tubes in a model for that counter with candidate alternative technologies. Thesemore » alternative technologies are initially placed in approximately the same configuration as the 3He tubes to establish a reference level of performance against the 3He-based system. After these reference-level results are established, the configurations of the alternative models will be further modified for performance optimization. The 3He model for these simulations is the one used by LANL to develop and benchmark the Epithermal Neutron Multiplicity Counter (ENMC) detector, as documented by H.O. Menlove, et al. in the 2004 LANL report LA-14088. The alternative technologies being evaluated are the boron-tri-fluoride-filled proportional tubes, boron-lined tubes, and lithium coated materials previously tested as possible replacements in portal monitor screening applications, as documented by R.T. Kouzes, et al. in the 2010 PNNL report PNNL-72544 and NIM A 623 (2010) 1035–1045. The models and methods used for these comparative calculations will be described and preliminary results shown« less

Assessment of Alternative Conceptual Models Using Reactive Transport Modeling with Monitoring Data

NASA Astrophysics Data System (ADS)

Dai, Z.; Price, V.; Heffner, D.; Hodges, R.; Temples, T.; Nicholson, T.

2005-12-01

Monitoring data proved very useful in evaluating alternative conceptual models, simulating contaminant transport behavior, and reducing uncertainty. A graded approach using three alternative conceptual site models was formulated to simulate a field case of tetrachloroethene (PCE) transport and biodegradation. These models ranged from simple to complex in their representation of subsurface heterogeneities. The simplest model was a single-layer homogeneous aquifer that employed an analytical reactive transport code, BIOCHLOR (Aziz et al., 1999). Due to over-simplification of the aquifer structure, this simulation could not reproduce the monitoring data. The second model consisted of a multi-layer conceptual model, in combination with numerical modules, MODFLOW and RT3D within GMS, to simulate flow and reactive transport. Although the simulation results from the second model were comparatively better than those from the simple model, they still did not adequately reproduce the monitoring well concentrations because the geological structures were still inadequately defined. Finally, a more realistic conceptual model was formulated that incorporated heterogeneities and geologic structures identified from well logs and seismic survey data using the Petra and PetraSeis software. This conceptual model included both a major channel and a younger channel that were detected in the PCE source area. In this model, these channels control the local ground-water flow direction and provide a preferential chemical transport pathway. Simulation results using this conceptual site model proved compatible with the monitoring concentration data. This study demonstrates that the bias and uncertainty from inadequate conceptual models are much larger than those introduced from an inadequate choice of model parameter values (Neuman and Wierenga, 2003; Meyer et al., 2004; Ye et al., 2004). This case study integrated conceptual and numerical models, based on interpreted local hydrogeologic and geochemical data, with detailed monitoring plume data. It provided key insights for confirming alternative conceptual site models and assessing the performance of monitoring networks. A monitoring strategy based on this graded approach for assessing alternative conceptual models can provide the technical bases for identifying critical monitoring locations, adequate monitoring frequency, and performance indicator parameters for performance monitoring involving ground-water levels and PCE concentrations.

Declining agricultural production in rapidly urbanizing semi-arid regions: policy tradeoffs and sustainability indicators

NASA Astrophysics Data System (ADS)

Dozier, André Q.; Arabi, Mazdak; Wostoupal, Benjamin C.; Goemans, Christopher G.; Zhang, Yao; Paustian, Keith

2017-08-01

In rapidly urbanizing semi-arid regions, increasing amounts of historically irrigated cropland lies permanently fallowed due to water court policies as agricultural water rights are voluntarily being sold to growing cities. This study develops an integrative framework for assessing the effects of population growth and land use change on agricultural production and evaluating viability of alternative management strategies, including alternative agricultural transfer methods, regional water ownership restrictions, and urban conservation. A partial equilibrium model of a spatially-diverse regional water rights market is built in application of the framework to an exemplary basin. The model represents agricultural producers as profit-maximizing suppliers and municipalities as cost-minimizing consumers of water rights. Results indicate that selling an agricultural water right today is worth up to two times more than 40 years of continued production. All alternative policies that sustain agricultural cropland and crop production decrease total agricultural profitability by diminishing water rights sales revenue, but in doing so, they also decrease municipal water acquisition costs. Defining good indicators and incorporating adequate spatial and temporal detail are critical to properly analyzing policy impacts. To best improve agricultural profit from production and sale of crops, short-term solutions include alternative agricultural transfer methods while long-term solutions incorporate urban conservation.

An alternative method for centrifugal compressor loading factor modelling

NASA Astrophysics Data System (ADS)

Galerkin, Y.; Drozdov, A.; Rekstin, A.; Soldatova, K.

2017-08-01

The loading factor at design point is calculated by one or other empirical formula in classical design methods. Performance modelling as a whole is out of consideration. Test data of compressor stages demonstrates that loading factor versus flow coefficient at the impeller exit has a linear character independent of compressibility. Known Universal Modelling Method exploits this fact. Two points define the function - loading factor at design point and at zero flow rate. The proper formulae include empirical coefficients. A good modelling result is possible if the choice of coefficients is based on experience and close analogs. Earlier Y. Galerkin and K. Soldatova had proposed to define loading factor performance by the angle of its inclination to the ordinate axis and by the loading factor at zero flow rate. Simple and definite equations with four geometry parameters were proposed for loading factor performance calculated for inviscid flow. The authors of this publication have studied the test performance of thirteen stages of different types. The equations are proposed with universal empirical coefficients. The calculation error lies in the range of plus to minus 1,5%. The alternative model of a loading factor performance modelling is included in new versions of the Universal Modelling Method.

Development of a Dynamic, End-to-End Free Piston Stirling Convertor Model

NASA Technical Reports Server (NTRS)

Regan, Timothy F.; Gerber, Scott S.; Roth, Mary Ellen

2004-01-01

A dynamic model for a free-piston Stirling convertor is being developed at the NASA Glenn Research Center. The model is an end-to-end system model that includes the cycle thermodynamics, the dynamics, and electrical aspects of the system. The subsystems of interest are the heat source, the springs, the moving masses, the linear alternator, the controller, and the end-user load. The envisioned use of the model will be in evaluating how changes in a subsystem could affect the operation of the convertor. The model under development will speed the evaluation of improvements to a subsystem and aid in determining areas in which most significant improvements may be found. One of the first uses of the end-toend model will be in the development of controller architectures. Another related area is in evaluating changes to details in the linear alternator.

Network Performance Evaluation Model for assessing the impacts of high-occupancy vehicle facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Janson, B.N.; Zozaya-Gorostiza, C.; Southworth, F.

1986-09-01

A model to assess the impacts of major high-occupancy vehicle (HOV) facilities on regional levels of energy consumption and vehicle air pollution emissions in urban aeas is developed and applied. This model can be used to forecast and compare the impacts of alternative HOV facility design and operation plans on traffic patterns, travel costs, model choice, travel demand, energy consumption and vehicle emissions. The model is designed to show differences in the overall impacts of alternative HOV facility types, locations and operation plans rather than to serve as a tool for detailed engineering design and traffic planning studies. The Networkmore » Performance Evaluation Model (NETPEM) combines several urban transportation planning models within a multi-modal network equilibrium framework including modules with which to define the type, location and use policy of the HOV facility to be tested, and to assess the impacts of this facility.« less

Development of a Dynamic, End-to-End Free Piston Stirling Convertor Model

NASA Astrophysics Data System (ADS)

Regan, Timothy F.; Gerber, Scott S.; Roth, Mary Ellen

2003-01-01

A dynamic model for a free-piston Stirling convertor is being developed at the NASA Glenn Research Center. The model is an end-to-end system model that includes the cycle thermodynamics, the dynamics, and electrical aspects of the system. The subsystems of interest are the heat source, the springs, the moving masses, the linear alternator, the controller and the end-user load. The envisioned use of the model will be in evaluating how changes in a subsystem could affect the operation of the convertor. The model under development will speed the evaluation of improvements to a subsystem and aid in determining areas in which most significant improvements may be found. One of the first uses of the end-to-end model will be in the development of controller architectures. Another related area is in evaluating changes to details in the linear alternator.

Economic evaluation of alternative crossbreeding systems involving four breeds of swine. I. The simulation model.

PubMed

McLaren, D G; Buchanan, D S; Williams, J E

1987-10-01

A static, deterministic computer model, programmed in Microsoft Basic for IBM PC and Apple Macintosh computers, was developed to calculate production efficiency (cost per kg of product) for nine alternative types of crossbreeding system involving four breeds of swine. The model simulates efficiencies for four purebred and 60 alternative two-, three- and four-breed rotation, rotaterminal, backcross and static cross systems. Crossbreeding systems were defined as including all purebred, crossbred and commercial matings necessary to maintain a total of 10,000 farrowings. Driving variables for the model are mean conception rate at first service and for an 8-wk breeding season, litter size born, preweaning survival rate, postweaning average daily gain, feed-to-gain ratio and carcass backfat. Predictions are computed using breed direct genetic and maternal effects for the four breeds, plus individual, maternal and paternal specific heterosis values, input by the user. Inputs required to calculate the number of females farrowing in each sub-system include the proportion of males and females replaced each breeding cycle in purebred and crossbred populations, the proportion of male and female offspring in seedstock herds that become breeding animals, and the number of females per boar. Inputs required to calculate the efficiency of terminal production (cost-to-product ratio) for each sub-system include breeding herd feed intake, gilt development costs, feed costs and labor and overhead costs. Crossbreeding system efficiency is calculated as the weighted average of sub-system cost-to-product ratio values, weighting by the number of females farrowing in each sub-system.

Do DSM-5 Section II personality disorders and Section III personality trait domains reflect the same genetic and environmental risk factors?

PubMed

Reichborn-Kjennerud, T; Krueger, R F; Ystrom, E; Torvik, F A; Rosenström, T H; Aggen, S H; South, S C; Neale, M C; Knudsen, G P; Kendler, K S; Czajkowski, N O

2017-09-01

DSM-5 includes two conceptualizations of personality disorders (PDs). The classification in Section II is identical to the one found in DSM-IV, and includes 10 categorical PDs. The Alternative Model (Section III) includes criteria for dimensional measures of maladaptive personality traits organized into five domains. The degree to which the two conceptualizations reflect the same etiological factors is not known. We use data from a large population-based sample of adult twins from the Norwegian Institute of Public Health Twin Panel on interview-based DSM-IV PDs and a short self-report inventory that indexes the five domains of the DSM-5 Alternative Model plus a domain explicitly targeting compulsivity. Schizotypal, Paranoid, Antisocial, Borderline, Avoidant, and Obsessive-compulsive PDs were assessed at the same time as the maladaptive personality traits and 10 years previously. Schizoid, Histrionic, Narcissistic, and Dependent PDs were only assessed at the first interview. Biometric models were used to estimate overlap in genetic and environmental risk factors. When measured concurrently, there was 100% genetic overlap between the maladaptive trait domains and Paranoid, Schizotypal, Antisocial, Borderline, and Avoidant PDs. For OCPD, 43% of the genetic variance was shared with the domains. Genetic correlations between the individual domains and PDs ranged from +0.21 to +0.91. The pathological personality trait domains, which are part of the Alternative Model for classification of PDs in DSM-5 Section III, appears to tap, at an aggregate level, the same genetic risk factors as the DSM-5 Section II classification for most of the PDs.

A Generalized Radiation Model for Human Mobility: Spatial Scale, Searching Direction and Trip Constraint

PubMed Central

Kang, Chaogui; Liu, Yu; Guo, Diansheng; Qin, Kun

2015-01-01

We generalized the recently introduced “radiation model”, as an analog to the generalization of the classic “gravity model”, to consolidate its nature of universality for modeling diverse mobility systems. By imposing the appropriate scaling exponent λ, normalization factor κ and system constraints including searching direction and trip OD constraint, the generalized radiation model accurately captures real human movements in various scenarios and spatial scales, including two different countries and four different cities. Our analytical results also indicated that the generalized radiation model outperformed alternative mobility models in various empirical analyses. PMID:26600153

A Shortcut to Estimating Economic Impact.

ERIC Educational Resources Information Center

Ryan, G. Jeremiah

1985-01-01

Describes a project which developed an alternative model for determining the economic impact of community colleges in New Jersey. Explains methods used to substitute for student and staff surveys, and the retail gravity model. Includes the instrument used to determine the individual college and statewide impacts and a bibliography. (AYC)

Planning level assessment of greenhouse gas emissions for alternative transportation construction projects : carbon footprint estimator, phase II, volume I - GASCAP model.

DOT National Transportation Integrated Search

2014-03-01

The GASCAP model was developed to provide a software tool for analysis of the life-cycle GHG : emissions associated with the construction and maintenance of transportation projects. This phase : of development included techniques for estimating emiss...

A Mixed-Methodological Examination of Investment Model Variables among Abused and Nonabused College Women

ERIC Educational Resources Information Center

Dardis, Christina M.; Kelley, Erika L.; Edwards, Katie M.; Gidycz, Christine A.

2013-01-01

Objective: This study assessed abused and nonabused women's perceptions of Investment Model (IM) variables (ie, relationship investment, satisfaction, commitment, quality of alternatives) utilizing a mixed-methods design. Participants: Participants included 102 college women, approximately half of whom were in abusive dating relationships.…

Mathematical Modelling in Engineering: An Alternative Way to Teach Linear Algebra

ERIC Educational Resources Information Center

Domínguez-García, S.; García-Planas, M. I.; Taberna, J.

2016-01-01

Technological advances require that basic science courses for engineering, including Linear Algebra, emphasize the development of mathematical strengths associated with modelling and interpretation of results, which are not limited only to calculus abilities. Based on this consideration, we have proposed a project-based learning, giving a dynamic…

Comparison of the Effects of Video Modeling with Narration vs. Video Modeling on the Functional Skill Acquisition of Adolescents with Autism

ERIC Educational Resources Information Center

Smith, Molly; Ayres, Kevin; Mechling, Linda; Smith, Katie

2013-01-01

The purpose of this study was to compare the effects of two forms of video modeling: video modeling that includes narration (VMN) and video models without narration (VM) on skill acquisition of four adolescent boys with a primary diagnosis of autism enrolled in an Extended School Year (ESY) summer program. An adapted alternating treatment design…

Space manufacturing in the construction of solar power satellites

NASA Astrophysics Data System (ADS)

Ruth, J.; Westphal, W.

This paper deals with ongoing research work concerning energy budget and cost of the solar Satellite Power System (SPS). The fundamental model of such a total system including ground and space facilities, transportation vehicles, power satellites and rectennas is presented. The main purpose of this model is to examine the applicability of different construction scenarios to allow comparison under nearly identical constraints. Using this model in a first attempt the blankets—meaning the main part of the space segment by weight, energy investment needs and cost—are chosen representatively for the energy and cost comparison of two construction alternatives of the same SPS concept. These construction alternatives are defined just by ground and space based manufacturing of the solar blankets, while all other subsystems, operations and the transportation profiles are considered to be kept the same. It can be shown that the energy "payback" time does not only depend on the SPS concept selected but also very much on the construction and implementation scenario. The cost comparison of these alternative approaches presents not very significant differences but advantages for the space manufacturing option with potential higher differences for a less conservative approach which may apply benefits of space manufacturing meaning, for example, considerable mass savings in space. Some preliminary results are discussed and an outlook is given over the next steps to be investigated, comprising the extension of the fundamental model to include use of lunar raw materials.

Scripting MODFLOW model development using Python and FloPy

USGS Publications Warehouse

Bakker, Mark; Post, Vincent E. A.; Langevin, Christian D.; Hughes, Joseph D.; White, Jeremy; Starn, Jeffrey; Fienen, Michael N.

2016-01-01

Graphical user interfaces (GUIs) are commonly used to construct and postprocess numerical groundwater flow and transport models. Scripting model development with the programming language Python is presented here as an alternative approach. One advantage of Python is that there are many packages available to facilitate the model development process, including packages for plotting, array manipulation, optimization, and data analysis. For MODFLOW-based models, the FloPy package was developed by the authors to construct model input files, run the model, and read and plot simulation results. Use of Python with the available scientific packages and FloPy facilitates data exploration, alternative model evaluations, and model analyses that can be difficult to perform with GUIs. Furthermore, Python scripts are a complete, transparent, and repeatable record of the modeling process. The approach is introduced with a simple FloPy example to create and postprocess a MODFLOW model. A more complicated capture-fraction analysis with a real-world model is presented to demonstrate the types of analyses that can be performed using Python and FloPy.

An index-based robust decision making framework for watershed management in a changing climate.

PubMed

Kim, Yeonjoo; Chung, Eun-Sung

2014-03-01

This study developed an index-based robust decision making framework for watershed management dealing with water quantity and quality issues in a changing climate. It consists of two parts of management alternative development and analysis. The first part for alternative development consists of six steps: 1) to understand the watershed components and process using HSPF model, 2) to identify the spatial vulnerability ranking using two indices: potential streamflow depletion (PSD) and potential water quality deterioration (PWQD), 3) to quantify the residents' preferences on water management demands and calculate the watershed evaluation index which is the weighted combinations of PSD and PWQD, 4) to set the quantitative targets for water quantity and quality, 5) to develop a list of feasible alternatives and 6) to eliminate the unacceptable alternatives. The second part for alternative analysis has three steps: 7) to analyze all selected alternatives with a hydrologic simulation model considering various climate change scenarios, 8) to quantify the alternative evaluation index including social and hydrologic criteria with utilizing multi-criteria decision analysis methods and 9) to prioritize all options based on a minimax regret strategy for robust decision. This framework considers the uncertainty inherent in climate models and climate change scenarios with utilizing the minimax regret strategy, a decision making strategy under deep uncertainty and thus this procedure derives the robust prioritization based on the multiple utilities of alternatives from various scenarios. In this study, the proposed procedure was applied to the Korean urban watershed, which has suffered from streamflow depletion and water quality deterioration. Our application shows that the framework provides a useful watershed management tool for incorporating quantitative and qualitative information into the evaluation of various policies with regard to water resource planning and management. Copyright © 2013 Elsevier B.V. All rights reserved.

Organization of left–right coordination of neuronal activity in the mammalian spinal cord: Insights from computational modelling

PubMed Central

Shevtsova, Natalia A; Talpalar, Adolfo E; Markin, Sergey N; Harris-Warrick, Ronald M; Kiehn, Ole; Rybak, Ilya A

2015-01-01

Different locomotor gaits in mammals, such as walking or galloping, are produced by coordinated activity in neuronal circuits in the spinal cord. Coordination of neuronal activity between left and right sides of the cord is provided by commissural interneurons (CINs), whose axons cross the midline. In this study, we construct and analyse two computational models of spinal locomotor circuits consisting of left and right rhythm generators interacting bilaterally via several neuronal pathways mediated by different CINs. The CIN populations incorporated in the models include the genetically identified inhibitory (V0D) and excitatory (V0V) subtypes of V0 CINs and excitatory V3 CINs. The model also includes the ipsilaterally projecting excitatory V2a interneurons mediating excitatory drive to the V0V CINs. The proposed network architectures and CIN connectivity allow the models to closely reproduce and suggest mechanistic explanations for several experimental observations. These phenomena include: different speed-dependent contributions of V0D and V0V CINs and V2a interneurons to left–right alternation of neural activity, switching gaits between the left–right alternating walking-like activity and the left–right synchronous hopping-like pattern in mutants lacking specific neuron classes, and speed-dependent asymmetric changes of flexor and extensor phase durations. The models provide insights into the architecture of spinal network and the organization of parallel inhibitory and excitatory CIN pathways and suggest explanations for how these pathways maintain alternating and synchronous gaits at different locomotor speeds. The models propose testable predictions about the neural organization and operation of mammalian locomotor circuits. Key points Coordination of neuronal activity between left and right sides of the mammalian spinal cord is provided by several sets of commissural interneurons (CINs) whose axons cross the midline. Genetically identified inhibitory V0D and excitatory V0V CINs and ipsilaterally projecting excitatory V2a interneurons were shown to secure left–right alternation at different locomotor speeds. We have developed computational models of neuronal circuits in the spinal cord that include left and right rhythm-generating centres interacting bilaterally via three parallel pathways mediated by V0D, V2a–V0V and V3 neuron populations. The models reproduce the experimentally observed speed-dependent left–right coordination in normal mice and the changes in coordination seen in mutants lacking specific neuron classes. The models propose an explanation for several experimental results and provide insights into the organization of the spinal locomotor network and parallel CIN pathways involved in gait control at different locomotor speeds. PMID:25820677

Schizophyllum commune has an extensive and functional alternative splicing repertoire

PubMed Central

Gehrmann, Thies; Pelkmans, Jordi F.; Lugones, Luis G.; Wösten, Han A. B.; Abeel, Thomas; Reinders, Marcel J. T.

2016-01-01

Recent genome-wide studies have demonstrated that fungi possess the machinery to alternatively splice pre-mRNA. However, there has not been a systematic categorization of the functional impact of alternative splicing in a fungus. We investigate alternative splicing and its functional consequences in the model mushroom forming fungus Schizophyllum commune. Alternative splicing was demonstrated for 2,285 out of 12,988 expressed genes, resulting in 20% additional transcripts. Intron retentions were the most common alternative splicing events, accounting for 33% of all splicing events, and 43% of the events in coding regions. On the other hand, exon skipping events were rare in coding regions (1%) but enriched in UTRs where they accounted for 57% of the events. Specific functional groups, including transcription factors, contained alternatively spliced genes. Alternatively spliced transcripts were regulated differently throughout development in 19% of the 2,285 alternatively spliced genes. Notably, 69% of alternatively spliced genes have predicted alternative functionality by loss or gain of functional domains, or by acquiring alternative subcellular locations. S. commune exhibits more alternative splicing than any other studied fungus. Taken together, alternative splicing increases the complexity of the S. commune proteome considerably and provides it with a rich repertoire of alternative functionality that is exploited dynamically. PMID:27659065

Schizophyllum commune has an extensive and functional alternative splicing repertoire

DOE PAGES

Gehrmann, Thies; Pelkmans, Jordi F.; Lugones, Luis G.; ...

2016-09-23

Recent genome-wide studies have demonstrated that fungi possess the machinery to alternatively splice pre-mRNA. However, there has not been a systematic categorization of the functional impact of alternative splicing in a fungus. We investigate alternative splicing and its functional consequences in the model mushroom forming fungus Schizophyllum commune. Alternative splicing was demonstrated for 2,285 out of 12,988 expressed genes, resulting in 20% additional transcripts. Intron retentions were the most common alternative splicing events, accounting for 33% of all splicing events, and 43% of the events in coding regions. On the other hand, exon skipping events were rare in coding regionsmore » (1%) but enriched in UTRs where they accounted for 57% of the events. Specific functional groups, including transcription factors, contained alternatively spliced genes. Alternatively spliced transcripts were regulated differently throughout development in 19% of the 2,285 alternatively spliced genes. Notably, 69% of alternatively spliced genes have predicted alternative functionality by loss or gain of functional domains, or by acquiring alternative subcellular locations. S. commune exhibits more alternative splicing than any other studied fungus. Finally, taken together, alternative splicing increases the complexity of the S. commune proteome considerably and provides it with a rich repertoire of alternative functionality that is exploited dynamically.« less

Incorporation of measured photosynthetic rate in a mathematical model for calculation of non-structural saccharide concentration

NASA Technical Reports Server (NTRS)

Lim, J. T.; Raper, C. D. Jr; Gold, H. J.; Wilkerson, G. G.; Raper CD, J. r. (Principal Investigator)

1989-01-01

A simple mathematical model for calculating the concentration of mobile carbon skeletons in the shoot of soya bean plants [Glycine max (L.) Merrill cv. Ransom] was built to examine the suitability of measured net photosynthetic rates (PN) for calculation of saccharide flux into the plant. The results suggest that either measurement of instantaneous PN overestimated saccharide influx or respiration rates utilized in the model were underestimated. If neither of these is the case, end-product inhibition of photosynthesis or waste respiration through the alternative pathway should be included in modelling of CH2O influx or efflux; and even if either of these is the case, the model output at a low coefficient of leaf activity indicates that PN still may be controlled by either end-product inhibition or alternative respiration.

A modeling assessment of the physicochemical properties and environmental fate of emerging and novel per- and polyfluoroalkyl substances.

PubMed

Gomis, Melissa Ines; Wang, Zhanyun; Scheringer, Martin; Cousins, Ian T

2015-02-01

Long-chain perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkane sulfonic acids (PFSAs) are persistent, bioaccumulative, and toxic contaminants that are globally present in the environment, wildlife and humans. Phase-out actions and use restrictions to reduce the environmental release of long-chain PFCAs, PFSAs and their precursors have been taken since 2000. In particular, long-chain poly- and perfluoroalkyl substances (PFASs) are being replaced with shorter-chain homologues or other fluorinated or non-fluorinated alternatives. A key question is: are these alternatives, particularly the structurally similar fluorinated alternatives, less hazardous to humans and the environment than the substances they replace? Several fluorinated alternatives including perfluoroether carboxylic acids (PFECAs) and perfluoroether sulfonic acids (PFESAs) have been recently identified. However, the scarcity of experimental data prevents hazard and risk assessments for these substances. In this study, we use state-of-the-art in silico tools to estimate key properties of these newly identified fluorinated alternatives. [i] COSMOtherm and SPARC are used to estimate physicochemical properties. The US EPA EPISuite software package is used to predict degradation half-lives in air, water and soil. [ii] In combination with estimated chemical properties, a fugacity-based multimedia mass-balance unit-world model - the OECD Overall Persistence (POV) and Long-Range Transport Potential (LRTP) Screening Tool - is used to assess the likely environmental fate of these alternatives. Even though the fluorinated alternatives contain some structural differences, their physicochemical properties are not significantly different from those of their predecessors. Furthermore, most of the alternatives are estimated to be similarly persistent and mobile in the environment as the long-chain PFASs. The models therefore predict that the fluorinated alternatives will become globally distributed in the environment similar to their predecessors. Although such in silico methods are coupled with uncertainties, this preliminary assessment provides enough cause for concern to warrant experimental work to better determine the properties of these fluorinated alternatives. Copyright © 2014 Elsevier B.V. All rights reserved.

Urgent Need for Improved Mental Health Care and a More Collaborative Model of Care

PubMed Central

Lake, James; Turner, Mason Spain

2017-01-01

Current treatments and the dominant model of mental health care do not adequately address the complex challenges of mental illness, which accounts for roughly one-third of adult disability globally. These circumstances call for radical change in the paradigm and practices of mental health care, including improving standards of clinician training, developing new research methods, and re-envisioning current models of mental health care delivery. Because of its dominant position in the US health care marketplace and its commitment to research and innovation, Kaiser Permanente (KP) is strategically positioned to make important contributions that will shape the future of mental health care nationally and globally. This article reviews challenges facing mental health care and proposes an agenda for developing a collaborative care model in primary care settings that incorporates conventional biomedical therapies and complementary and alternative medicine approaches. By moving beyond treatment delivery via telephone and secure video and providing earlier interventions through primary care clinics, KP is shifting the paradigm of mental health care to a collaborative care model focusing on prevention. Recommendations are to expand current practices to include integrative treatment strategies incorporating evidence-based biomedical and complementary and alternative medicine modalities that can be provided to patients using a collaborative care model. Recommendations also are made for an internal research program aimed at investigating the efficacy and cost-effectiveness of promising complementary and alternative medicine and integrative treatments addressing the complex needs of patients with severe psychiatric disorders, many of whom respond poorly to treatments available in KP mental health clinics. PMID:28898197

Behavioral and Organizational Considerations in the Design of Information Systems and Processes for Planning and Decision Support,

DTIC Science & Technology

1981-06-01

analysis and display capability provided by management information systems to include interpretation and aggregation of information and values such as...accomplishment of these) 2. analysis of the issue d) systems analysis and modeling (determination of the structure of the decision situation, the...existingltrtie2) Surveying lsata i situation’ alternatives I altraivDsad Is this alternative -" altrnav acceptable? ANALYSIS o NOYES SHave a sufficient

A Generalized DBMS to Support Diversified Data.

DTIC Science & Technology

1987-07-21

interest on bonds ). Hence. they require a definition of subtraction which yields 30 days as the answer to the above computation. Only a user-defined...STON85]. Alternately. one can follow the standard scheduler model [BERNS1] in which a module is callable by code in the access methods when a...direction for evolution . These could include when to cease investigating alternate plans. and the ability to specify one’s own optimizer parameters

Deletion Diagnostics for Alternating Logistic Regressions

PubMed Central

Preisser, John S.; By, Kunthel; Perin, Jamie; Qaqish, Bahjat F.

2013-01-01

Deletion diagnostics are introduced for the regression analysis of clustered binary outcomes estimated with alternating logistic regressions, an implementation of generalized estimating equations (GEE) that estimates regression coefficients in a marginal mean model and in a model for the intracluster association given by the log odds ratio. The diagnostics are developed within an estimating equations framework that recasts the estimating functions for association parameters based upon conditional residuals into equivalent functions based upon marginal residuals. Extensions of earlier work on GEE diagnostics follow directly, including computational formulae for one-step deletion diagnostics that measure the influence of a cluster of observations on the estimated regression parameters and on the overall marginal mean or association model fit. The diagnostic formulae are evaluated with simulations studies and with an application concerning an assessment of factors associated with health maintenance visits in primary care medical practices. The application and the simulations demonstrate that the proposed cluster-deletion diagnostics for alternating logistic regressions are good approximations of their exact fully iterated counterparts. PMID:22777960

Health courts: an alternative to traditional tort law.

PubMed

Miller, Lisa A

2011-01-01

The current adversarial tort-based system of adjudicating malpractice claims is flawed. Alternate methods of compensation for birth injuries related to oxygen deprivation or mechanical injury are being utilized in Virginia and Florida. Although utilization of both of these schemes is limited, and they are not without problems in application, both have been successful in reducing the number of malpractice claims in the tort system and in reducing malpractice premiums. While the Florida and Virginia programs are primarily focused on compensation, other models outside the US focus include compensation as well as enhanced dispute resolution and potential for clinical practice change through peer review. Experts in the fields of law and public policy in the United States have evaluated a variety of approaches and have proposed models for administrative health courts that would provide both compensation and dispute resolution for medical and nursing malpractice claims. These alternative models are based on transparency and disclosure, with just compensation for injuries, and opportunities for improvements in patient safety.

The FFOCI and other measures and models of OCPD.

PubMed

Crego, Cristina; Samuel, Douglas B; Widiger, Thomas A

2015-04-01

The Five Factor Obsessive Compulsive Inventory (FFOCI) was developed in part to facilitate a shift from the categorical classification of personality disorder to a dimensional trait model, more specifically, the five-factor model (FFM). Questions though have been raised as to whether obsessive-compulsive personality disorder (OCPD) can be understood as a maladaptive variant of FFM conscientiousness. The present study provides a further validation of the FFOCI, emphasizing in particular its association with FFM conscientiousness, as well as comparing alternative measures and models of OCPD. A total of 380 undergraduates (obtained in two samples of 274 and 106), including 146 oversampled for OCPD traits (93 for the first sample and 53 for the second), completed the FFOCI, measures of general personality, OCPD trait scales, and alternative measures of OCPD. Results supported the validity of the FFOCI as a measure of OCPD and maladaptive variants of FFM traits, as well as identifying substantive differences among the alternative measures of OCPD, particularly with respect to their relationship with FFM conscientiousness, antagonism, and introversion. © The Author(s) 2014.

Feminism meets the "new" epidemiologies: toward an appraisal of antifeminist biases in epidemiological research on women's health.

PubMed

Inhorn, M C; Whittle, K L

2001-09-01

This essay explores an alternative paradigm for epidemiology, one which is explicitly informed by a feminist perspective. We intend to expand upon recent critiques and debates within the emergent fields of "critical", "popular", and "alternative" epidemiology to examine how epidemiology's conceptual models--which are meant to contribute to the prevention of social inequalities in health, but may instead reinforce social hierarchies based on gender, race, and class--constrain our understanding of health and disease. Specifically, we examine persistent antifeminist biases in contemporary epidemiological research on women's health. Issues highlighted include: problem definition and knowledge production in women's health: biological essentialization of women as reproducers; and decontextualization and depoliticization of women's health risks. As part of this critique, we include suggestions for an emancipatory epidemiology that incorporates an alternative feminist framework.

The use of coupled atmospheric and hydrological models for water-resources management in headwater basins

USGS Publications Warehouse

Leavesley, G.; Hay, L.

1998-01-01

Coupled atmospheric and hydrological models provide an opportunity for the improved management of water resources in headwater basins. Issues currently limiting full implementation of coupled-model methodologies include (a) the degree of uncertainty in the accuracy of precipitation and other meteorological variables simulated by atmospheric models, and (b) the problem of discordant scales between atmospheric and bydrological models. Alternative methodologies being developed to address these issues are reviewed.

Use of complementary and alternative medicine and breast cancer survival in the Health, Eating, Activity, and Lifestyle Study.

PubMed

Neuhouser, Marian L; Smith, Ashley Wilder; George, Stephanie M; Gibson, James T; Baumgartner, Kathy B; Baumgartner, Richard; Duggan, Catherine; Bernstein, Leslie; McTiernan, Anne; Ballard, Rachel

2016-12-01

Use of complementary and alternative medicine (CAM) is common among breast cancer patients, but less is known about whether CAM influences breast cancer survival. Health Eating, Activity, and Lifestyle (HEAL) Study participants (n = 707) were diagnosed with stage I-IIIA breast cancer. Participants completed a 30-month post-diagnosis interview including questions on CAM use (natural products such as dietary and botanical supplements, alternative health practices, and alternative medical systems), weight, physical activity, and comorbidities. Outcomes were breast cancer-specific and total mortality, which were ascertained from the Surveillance Epidemiology and End Results registries in Western Washington, Los Angeles County, and New Mexico. Cox proportional hazards regression models were fit to data to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for mortality. Models were adjusted for potential confounding by sociodemographic, health, and cancer-related factors. Among 707 participants, 70 breast cancer-specific deaths and 149 total deaths were reported. 60.2 % of participants reported CAM use post-diagnosis. The most common CAM were natural products (51 %) including plant-based estrogenic supplements (42 %). Manipulative and body-based practices and alternative medical systems were used by 27 and 13 % of participants, respectively. No associations were observed between CAM use and breast cancer-specific (HR 1.04, 95 % CI 0.61-1.76) or total mortality (HR 0.91, 95 % CI 0.63-1.29). Complementary and alternative medicine use was not associated with breast cancer-specific mortality or total mortality. Randomized controlled trials may be needed to definitively test whether there is harm or benefit from the types of CAM assessed in HEAL in relation to mortality outcomes in breast cancer survivors.

A Hydrostratigraphic Framework Model and Alternatives for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 98: Frenchman Flat, Clark, Lincoln and Nye Counties, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bechtel Nevada

2005-09-01

A new, revised three-dimensional (3-D) hydrostratigraphic framework model for Frenchman Flat was completed in 2004. The area of interest includes Frenchman Flat, a former nuclear testing area at the Nevada Test Site, and proximal areas. Internal and external reviews of an earlier (Phase I) Frenchman Flat model recommended additional data collection to address uncertainties. Subsequently, additional data were collected for this Phase II initiative, including five new drill holes and a 3-D seismic survey.

Exemplar-Based Clustering via Simulated Annealing

ERIC Educational Resources Information Center

Brusco, Michael J.; Kohn, Hans-Friedrich

2009-01-01

Several authors have touted the p-median model as a plausible alternative to within-cluster sums of squares (i.e., K-means) partitioning. Purported advantages of the p-median model include the provision of "exemplars" as cluster centers, robustness with respect to outliers, and the accommodation of a diverse range of similarity data. We developed…

Modeling Reading Growth in Grades 3 to 5 with an Alternate Assessment

ERIC Educational Resources Information Center

Farley, Dan; Anderson, Daniel; Irvin, P. Shawn; Tindal, Gerald

2017-01-01

Modeling growth for students with significant cognitive disabilities (SWSCD) is difficult due to a variety of factors, including, but not limited to, missing data, test scaling, group heterogeneity, and small sample sizes. These challenges may account for the paucity of previous research exploring the academic growth of SWSCD. Our study represents…

Reason, Intuition, and Social Justice: Elaborating on Parson's Career Decision-Making Model.

ERIC Educational Resources Information Center

Hartung, Paul J.; Blustein, David L.

2002-01-01

Nearly a century ago, Frank Parsons established the Vocation Bureau in Boston and spawned the development of the counseling profession. Elaborating on Parsons's socially responsible vision for counseling, the authors examine contemporary perspectives on career decision making that include both rational and alternative models and propose that these…

Abiotic Transformation Of Estrogens In Synthetic Municipal Wastewater: An Alternative For Treatment?

EPA Science Inventory

The abiotic transformation of estrogens, including estrone (E1), estradiol (E2), estriol (E3) and ethinylestradiol (EE2), in the presence of model vegetable matter was confirmed in this study. Batch experiments were performed to model the catalytic conversion of E1, E2, E3, and ...

Video Modeling for Children and Adolescents with Autism Spectrum Disorder: A Meta-Analysis

ERIC Educational Resources Information Center

Thompson, Teresa Lynn

2014-01-01

The objective of this research was to conduct a meta-analysis to examine existing research studies on video modeling as an effective teaching tool for children and adolescents diagnosed with Autism Spectrum Disorder (ASD). Study eligibility criteria included (a) single case research design using multiple baselines, alternating treatment designs,…

A Simulation Study of Methods for Selecting Subgroup-Specific Doses in Phase I Trials

PubMed Central

Morita, Satoshi; Thall, Peter F.; Takeda, Kentaro

2016-01-01

Summary Patient heterogeneity may complicate dose-finding in phase I clinical trials if the dose-toxicity curves differ between subgroups. Conducting separate trials within subgroups may lead to infeasibly small sample sizes in subgroups having low prevalence. Alternatively, it is not obvious how to conduct a single trial while accounting for heterogeneity. To address this problem, we consider a generalization of the continual reassessment method (O’Quigley, et al., 1990) based on a hierarchical Bayesian dose-toxicity model that borrows strength between subgroups under the assumption that the subgroups are exchangeable. We evaluate a design using this model that includes subgroup-specific dose selection and safety rules. A simulation study is presented that includes comparison of this method to three alternative approaches, based on non-hierarchical models, that make different types of assumptions about within-subgroup dose-toxicity curves. The simulations show that the hierarchical model-based method is recommended in settings where the dose-toxicity curves are exchangeable between subgroups. We present practical guidelines for application, and provide computer programs for trial simulation and conduct. PMID:28111916

Economic models for prevention: making a system work for patients

PubMed Central

2015-01-01

The purpose of this article is to describe alternative means of providing patient centered, preventive based, services using an alternative non-profit, economic model. Hard to reach, vulnerable groups, including children, adults and elders, often have difficulties accessing traditional dental services for a number of reasons, including economic barriers. By partnering with community organizations that serve these groups, collaborative services and new opportunities for access are provided. The concept of a dental home is well accepted as a means of providing care, and, for these groups, provision of such services within community settings provides a sustainable means of delivery. Dental homes provided through community partnerships can deliver evidence based dental care, focused on a preventive model to achieve and maintain oral health. By using a non-profit model, the entire dental team is provided with incentives to deliver measurable quality improvements in care, rather than a more traditional focus on volume of activity alone. Examples are provided that demonstrate how integrated oral health services can deliver improved health outcomes with the potential to reduce total costs while improving quality. PMID:26391814

Tools and Techniques for Basin-Scale Climate Change Assessment

NASA Astrophysics Data System (ADS)

Zagona, E.; Rajagopalan, B.; Oakley, W.; Wilson, N.; Weinstein, P.; Verdin, A.; Jerla, C.; Prairie, J. R.

2012-12-01

The Department of Interior's WaterSMART Program seeks to secure and stretch water supplies to benefit future generations and identify adaptive measures to address climate change. Under WaterSMART, Basin Studies are comprehensive water studies to explore options for meeting projected imbalances in water supply and demand in specific basins. Such studies could be most beneficial with application of recent scientific advances in climate projections, stochastic simulation, operational modeling and robust decision-making, as well as computational techniques to organize and analyze many alternatives. A new integrated set of tools and techniques to facilitate these studies includes the following components: Future supply scenarios are produced by the Hydrology Simulator, which uses non-parametric K-nearest neighbor resampling techniques to generate ensembles of hydrologic traces based on historical data, optionally conditioned on long paleo reconstructed data using various Markov Chain techniuqes. Resampling can also be conditioned on climate change projections from e.g., downscaled GCM projections to capture increased variability; spatial and temporal disaggregation is also provided. The simulations produced are ensembles of hydrologic inputs to the RiverWare operations/infrastucture decision modeling software. Alternative demand scenarios can be produced with the Demand Input Tool (DIT), an Excel-based tool that allows modifying future demands by groups such as states; sectors, e.g., agriculture, municipal, energy; and hydrologic basins. The demands can be scaled at future dates or changes ramped over specified time periods. Resulting data is imported directly into the decision model. Different model files can represent infrastructure alternatives and different Policy Sets represent alternative operating policies, including options for noticing when conditions point to unacceptable vulnerabilities, which trigger dynamically executing changes in operations or other options. The over-arching Study Manager provides a graphical tool to create combinations of future supply scenarios, demand scenarios, infrastructure and operating policy alternatives; each scenario is executed as an ensemble of RiverWare runs, driven by the hydrologic supply. The Study Manager sets up and manages multiple executions on multi-core hardware. The sizeable are typically direct model outputs, or post-processed indicators of performance based on model outputs. Post processing statistical analysis of the outputs are possible using the Graphical Policy Analysis Tool or other statistical packages. Several Basin Studies undertaken have used RiverWare to evaluate future scenarios. The Colorado River Basin Study, the most complex and extensive to date, has taken advantage of these tools and techniques to generate supply scenarios, produce alternative demand scenarios and to set up and execute the many combinations of supplies, demands, policies, and infrastructure alternatives. The tools and techniques will be described with example applications.

Parametric study of supersonic STOVL flight characteristics

NASA Technical Reports Server (NTRS)

Rapp, David C.

1985-01-01

A number of different control devices and techniques are evaluated to determine their suitability for increasing the short takeoff performance of a supersonic short-takeoff/vertical landing (STOVL) aircraft. Analysis was based on a rigid-body mathematical model of the General Dynamics E-7, a single engine configuration that utilizes ejectors and thrust deflection for propulsive lift. Alternatives investigated include increased static pitch, the addition of a close-coupled canard, use of boundary layer control to increase the takeoff lift coefficient, and the addition of a vectorable aft fan air nozzle. Other performance studies included the impact of individual E-7 features, the sensitivity to ejector performance, the effect of removing the afterburners, and a determination of optional takeoff and landing transition methods. The results pertain to both the E-7 and other configurations. Several alternatives were not as well suited to the E-7 characteristics as they would be to an alternative configuration, and vice versa. A large amount of supporting data for each analysis is included.

Life-Cycle Analysis of Alternative Aviation Fuels in GREET

DOT National Transportation Integrated Search

2012-06-01

The Greenhouse gases, Regulated Emissions, and Energy use in Transportation (GREET) model was expanded to include aviation fuel production pathways and aircraft operations, allowing researchers to examine the environmental sustainability of various a...

Accounting for costs, QALYs, and capacity constraints: using discrete-event simulation to evaluate alternative service delivery and organizational scenarios for hospital-based glaucoma services.

PubMed

Crane, Glenis J; Kymes, Steven M; Hiller, Janet E; Casson, Robert; Martin, Adam; Karnon, Jonathan D

2013-11-01

Decision-analytic models are routinely used as a framework for cost-effectiveness analyses of health care services and technologies; however, these models mostly ignore resource constraints. In this study, we use a discrete-event simulation model to inform a cost-effectiveness analysis of alternative options for the organization and delivery of clinical services in the ophthalmology department of a public hospital. The model is novel, given that it represents both disease outcomes and resource constraints in a routine clinical setting. A 5-year discrete-event simulation model representing glaucoma patient services at the Royal Adelaide Hospital (RAH) was implemented and calibrated to patient-level data. The data were sourced from routinely collected waiting and appointment lists, patient record data, and the published literature. Patient-level costs and quality-adjusted life years were estimated for a range of alternative scenarios, including combinations of alternate follow-up times, booking cycles, and treatment pathways. The model shows that a) extending booking cycle length from 4 to 6 months, b) extending follow-up visit times by 2 to 3 months, and c) using laser in preference to medication are more cost-effective than current practice at the RAH eye clinic. The current simulation model provides a useful tool for informing improvements in the organization and delivery of glaucoma services at a local level (e.g., within a hospital), on the basis of expected effects on costs and health outcomes while accounting for current capacity constraints. Our model may be adapted to represent glaucoma services at other hospitals, whereas the general modeling approach could be applied to many other clinical service areas.

Women's motivation, perception and experience of complementary and alternative medicine in pregnancy: A meta-synthesis.

PubMed

Bowman, Rebekah L; Davis, Deborah L; Ferguson, Sally; Taylor, Jan

2018-04-01

complementary and Alternative Medicine use during pregnancy is popular in many countries, including Australia. There is currently little evidence to support this practice, which raises the question of women's motivation for use of these therapies and the experiences they encounter. this study aims to explore the perceptions, motivations and experiences of pregnant women with regard to their use of Complementary and Alternative Medicine during pregnancy. a systemic review and meta-synthesis of the available research was conducted. Five databases were explored - CINAHL Plus, Medline, PubMed, AMED and Web of Science using the search terms complementary and alternative medicine; pregnancy; and pregnant. Articles included in this meta-synthesis were screened using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses tool. ten initial themes were drawn from the six studies. These ten themes were summarised by three cluster themes. The results suggest that women are using Complementary and Alternative Medicine in their pregnancy as a means of supporting their sense of self-determination, to pursue a natural and safe childbirth, and because they experience a close affiliation with the philosophical underpinnings of Complementary and Alternative Medicine as an alternative to the biomedical model. these findings are important to practitioners, policy makers, governing bodies and researchers, providing insight into the motivations for Complementary and Alternative Medicine use by women in pregnancy. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Comparing statistical and machine learning classifiers: alternatives for predictive modeling in human factors research.

PubMed

Carnahan, Brian; Meyer, Gérard; Kuntz, Lois-Ann

2003-01-01

Multivariate classification models play an increasingly important role in human factors research. In the past, these models have been based primarily on discriminant analysis and logistic regression. Models developed from machine learning research offer the human factors professional a viable alternative to these traditional statistical classification methods. To illustrate this point, two machine learning approaches--genetic programming and decision tree induction--were used to construct classification models designed to predict whether or not a student truck driver would pass his or her commercial driver license (CDL) examination. The models were developed and validated using the curriculum scores and CDL exam performances of 37 student truck drivers who had completed a 320-hr driver training course. Results indicated that the machine learning classification models were superior to discriminant analysis and logistic regression in terms of predictive accuracy. Actual or potential applications of this research include the creation of models that more accurately predict human performance outcomes.

What if ? On alternative conceptual models and the problem of their implementation

NASA Astrophysics Data System (ADS)

Neuberg, Jurgen

2015-04-01

Seismic and other monitoring techniques rely on a set of conceptual models on the base of which data sets can be interpreted. In order to do this on an operational level in volcano observatories these models need to be tested and ready for an interpretation in a timely manner. Once established, scientists in charge advising stakeholders and decision makers often stick firmly to these models to avoid confusion by giving alternative versions of interpretations to non-experts. This talk gives an overview of widely accepted conceptual models to interpret seismic and deformation data, and highlights in a few case studies some of the arising problems. Aspects covered include knowledge transfer between research institutions and observatories, data sharing, the problem of up-taking advice, and some hidden problems which turn out to be much more critical in assessing volcanic hazard than the actual data interpretation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wellman, Dawn M.; Freshley, Mark D.; Truex, Michael J.

Current requirements for site remediation and closure are standards-based and are often overly conservative, costly, and in some cases, technically impractical to achieve. Use of risk-informed alternate endpoints provide a means to achieve remediation goals that are permitted by regulations and are protective of human health and the environment. Alternate endpoints enable establishing a path for cleanup that may include intermediate remedial milestones and transition points and/or regulatory alternatives to standards-based remediation. A framework is presented that is centered around developing and refining conceptual models in conjunction with assessing risks and potential endpoints as part of a system-based assessment thatmore » integrates site data with scientific understanding of processes that control the distribution and transport of contaminants in the subsurface and pathways to receptors. This system based assessment and subsequent implementation of the remediation strategy with appropriate monitoring are targeted at providing a holistic approach to addressing risks to human health and the environment. This holistic approach also enables effective predictive analysis of contaminant behavior to provide defensible criteria and data for making long-term decisions. Developing and implementing an alternate endpoint-based approach for remediation and waste site closure presents a number of challenges and opportunities. Categories of these challenges include scientific and technical, regulatory, institutional, and budget and resource allocation issues. Opportunities exist for developing and implementing systems-based approaches with respect to supportive characterization, monitoring, predictive modeling, and remediation approaches.« less

Women at the Top: Powerful Leaders Define Success as Work + Family in a Culture of Gender

ERIC Educational Resources Information Center

Cheung, Fanny M.; Halpern, Diane F.

2010-01-01

How do women rise to the top of their professions when they also have significant family care responsibilities? This critical question has not been addressed by existing models of leadership. In a review of recent research, we explore an alternative model to the usual notion of a Western male as the prototypical leader. The model includes (a)…

Micro-Tom Tomato as an Alternative Plant Model System: Mutant Collection and Efficient Transformation.

PubMed

Shikata, Masahito; Ezura, Hiroshi

2016-01-01

Tomato is a model plant for fruit development, a unique feature that classical model plants such as Arabidopsis and rice do not have. The tomato genome was sequenced in 2012 and tomato is becoming very popular as an alternative system for plant research. Among many varieties of tomato, Micro-Tom has been recognized as a model cultivar for tomato research because it shares some key advantages with Arabidopsis including its small size, short life cycle, and capacity to grow under fluorescent lights at a high density. Mutants and transgenic plants are essential materials for functional genomics research, and therefore, the availability of mutant resources and methods for genetic transformation are key tools to facilitate tomato research. Here, we introduce the Micro-Tom mutant database "TOMATOMA" and an efficient transformation protocol for Micro-Tom.

Annual Screening Strategies in BRCA1 and BRCA2 Gene Mutation Carriers: A Comparative Effectiveness Analysis

PubMed Central

Lowry, Kathryn P.; Lee, Janie M.; Kong, Chung Y.; McMahon, Pamela M.; Gilmore, Michael E.; Cott Chubiz, Jessica E.; Pisano, Etta D.; Gatsonis, Constantine; Ryan, Paula D.; Ozanne, Elissa M.; Gazelle, G. Scott

2011-01-01

Background While breast cancer screening with mammography and MRI is recommended for BRCA mutation carriers, there is no current consensus on the optimal screening regimen. Methods We used a computer simulation model to compare six annual screening strategies [film mammography (FM), digital mammography (DM), FM and magnetic resonance imaging (MRI) or DM and MRI contemporaneously, and alternating FM/MRI or DM/MRI at six-month intervals] beginning at ages 25, 30, 35, and 40, and two strategies of annual MRI with delayed alternating DM/FM to clinical surveillance alone. Strategies were evaluated without and with mammography-induced breast cancer risk, using two models of excess relative risk. Input parameters were obtained from the medical literature, publicly available databases, and calibration. Results Without radiation risk effects, alternating DM/MRI starting at age 25 provided the highest life expectancy (BRCA1: 72.52 years, BRCA2: 77.63 years). When radiation risk was included, a small proportion of diagnosed cancers were attributable to radiation exposure (BRCA1: <2%, BRCA2: <4%). With radiation risk, alternating DM/MRI at age 25 or annual MRI at age 25/delayed alternating DM at age 30 were most effective, depending on the radiation risk model used. Alternating DM/MRI starting at age 25 also had the highest number of false-positive screens/person (BRCA1: 4.5, BRCA2: 8.1). Conclusions Annual MRI at 25/delayed alternating DM at age 30 is likely the most effective screening strategy in BRCA mutation carriers. Screening benefits, associated risks and personal acceptance of false-positive results, should be considered in choosing the optimal screening strategy for individual women. PMID:21935911

Traffic-related air pollution and health co-benefits of alternative transport in Adelaide, South Australia.

PubMed

Xia, Ting; Nitschke, Monika; Zhang, Ying; Shah, Pushan; Crabb, Shona; Hansen, Alana

2015-01-01

Motor vehicle emissions contribute nearly a quarter of the world's energy-related greenhouse gases and cause non-negligible air pollution, primarily in urban areas. Changing people's travel behaviour towards alternative transport is an efficient approach to mitigate harmful environmental impacts caused by a large number of vehicles. Such a strategy also provides an opportunity to gain health co-benefits of improved air quality and enhanced physical activities. This study aimed at quantifying co-benefit effects of alternative transport use in Adelaide, South Australia. We made projections for a business-as-usual scenario for 2030 with alternative transport scenarios. Separate models including air pollution models and comparative risk assessment health models were developed to link alternative transport scenarios with possible environmental and health benefits. In the study region with an estimated population of 1.4 million in 2030, by shifting 40% of vehicle kilometres travelled (VKT) by passenger vehicles to alternative transport, annual average urban PM2.5 would decline by approximately 0.4μg/m(3) compared to business-as-usual, resulting in net health benefits of an estimated 13deaths/year prevented and 118 disability-adjusted life years (DALYs) prevented per year due to improved air quality. Further health benefits would be obtained from improved physical fitness through active transport (508deaths/year prevented, 6569DALYs/year prevented), and changes in traffic injuries (21 deaths and, 960 DALYs prevented). Although uncertainties remain, our findings suggest that significant environmental and health benefits are possible if alternative transport replaces even a relatively small portion of car trips. The results may provide assistance to various government organisations and relevant service providers and promote collaboration in policy-making, city planning and infrastructure establishment. Copyright © 2014 Elsevier Ltd. All rights reserved.

Geohydrology and simulation of ground-water flow near Los Alamos, north-central New Mexico

USGS Publications Warehouse

Frenzel, P.F.

1995-01-01

An existing model was modified in recognition of new geohydrologic interpretations and adjusted to simulate hydrographs in well fields in the Los Alamos area. Hydraulic-head drawdowns at the Buckman well field resulting from two projected ground-water-withdrawal alternatives were estimated with the modified model. The Chaquehui formation (informal usage) is the main new feature of recent hydrologic interpretations for the Los Alamos area. The Chaquehui occupies a 'channel' that was eroded or faulted into the Tesuque Formation, and the Chaquehui is more permeable than the Tesuque. The Chaquehui is a major producing zone in the Pajarito Mesa well field and to a lesser extent in the Guaje well field. Model modification included splitting the four layers of the McAda-Wasiolek model (McAda, D.P., and Wasiolek, Maryann, 1988, Simulation of the regional geohydrology of the Tesuque aquifer system near Santa Fe, New Mexico: U.S. Geological Survey Water- Resources Investigations Report 87-4056, 71 p.) into eight layers to better simulate vertical ground-water movement. Other model modifications were limited as much as possible to the area of interest near Los Alamos and consisted mainly of adjusting hydraulic-conductivity values representing the Tesuque Formation, Chaquehui formation (informal usage), and Puye Formation, and adjusting simulated recharge along the Pajarito Fault Zone west of Los Alamos. Adjustments were based mainly on simulation of fluctuations in measured hydraulic heads near Los Alamos. Two possible alternative plans for replacing Guaje well field production were suggested by Los Alamos National Laboratory. In the first plan (Guaje alternative), the Guaje field would be renewed with four new wells replacing the existing production wells in the Guaje field. In the second plan (Pajarito-Otowi alternative), the Guaje well field would be retired and its former production would be made up by additional withdrawals from the Pajarito Mesa and Otowi well fields. A projection for each of these alternatives was made through 2012 using the new eight- layer model. In the Guaje field, projected hydraulic heads at the end of 2012 were as much as 50 feet lower with the Guaje alternative; in the Pajarito Mesa field, hydraulic heads were as much as 12 feet higher with the Guaje alternative. At the western end of the Los Alamos well field, projected hydraulic heads were about 20 feet higher with the Guaje alternative; at the eastern end of the Los Alamos field, the difference between alternatives was much less. At the Buckman field, projected hydraulic heads were about 2 feet higher with the Guaje alternative because the Buckman field is closer to the Pajarito Mesa field than to the Guaje field. Ways of improving the understanding of the flow system include developing a more accurate representation of the structure and extent of the Tesuque Formation, Chaquehui formation, and Puye Formation of the Santa Fe Group and obtaining more detailed geologic and hydrologic data for the Chaquehui and Puye. Data that describe water chemistry, hydraulic head, and degree of saturation would be valuable for determining the location and quantity of recharge on the Pajarito Plateau, especially along the west side of the Plateau and in canyon bottoms. Chloride concentrations in soil at the top of the Bandelier Tuff could be used to verify the concept that evapotranspiration accounts for nearly all precipitation over a large area of the plateau.

Multiple frequency bioelectrical impedance analysis: a cross-validation study of the inductor circuit and Cole models.

PubMed

Ward, L; Cornish, B H; Paton, N I; Thomas, B J

1999-11-01

It has been proposed that multiple frequency bioelectrical impedance models of the human body should include an inductive property for the circulatory system, the inductor circuit model (ICM), and that such a model, when coupled with a new method of data analysis, can improve the predictive power of multiple frequency bioelectrical impedance analysis (MFBIA). This hypothesis was tested using MFBIA measurements and gold standard measures of total body and extracellular water volumes in a cross-validation study in two subject groups (viz. controls and HIV). The MFBIA measurements were analysed using the current, widely accepted Cole model and the alternative ICM model which includes an inductive component. Correlations in the range 0.75 to 0.92 (for TBW) and 0.46 to 0.79 (for ECW) for impedance quotients versus gold standard measures within the subject groups were observed. These decreased, to as low as r = 0.50 for TBW and r = 0.29 for ECW, when the derived algorithms were applied to the alternative subject group. These results suggest that lack of portability of MFBIA algorithms between subject groups is not due to an inadequacy of the analogue circuit model per se but is possibly due more to fundamental flaws in the principles associated with its application. These include assuming a constant proportionality of body segment geometries and tissue fluid resistivities. This study has also demonstrated that this inadequacy cannot be overcome by simply introducing an inductive component into the analogue electrical circuit.

Combustion instability and active control: Alternative fuels, augmentors, and modeling heat release

NASA Astrophysics Data System (ADS)

Park, Sammy Ace

Experimental and analytical studies were conducted to explore thermo-acoustic coupling during the onset of combustion instability in various air-breathing combustor configurations. These include a laboratory-scale 200-kW dump combustor and a 100-kW augmentor featuring a v-gutter flame holder. They were used to simulate main combustion chambers and afterburners in aero engines, respectively. The three primary themes of this work includes: 1) modeling heat release fluctuations for stability analysis, 2) conducting active combustion control with alternative fuels, and 3) demonstrating practical active control for augmentor instability suppression. The phenomenon of combustion instabilities remains an unsolved problem in propulsion engines, mainly because of the difficulty in predicting the fluctuating component of heat release without extensive testing. A hybrid model was developed to describe both the temporal and spatial variations in dynamic heat release, using a separation of variables approach that requires only a limited amount of experimental data. The use of sinusoidal basis functions further reduced the amount of data required. When the mean heat release behavior is known, the only experimental data needed for detailed stability analysis is one instantaneous picture of heat release at the peak pressure phase. This model was successfully tested in the dump combustor experiments, reproducing the correct sign of the overall Rayleigh index as well as the remarkably accurate spatial distribution pattern of fluctuating heat release. Active combustion control was explored for fuel-flexible combustor operation using twelve different jet fuels including bio-synthetic and Fischer-Tropsch types. Analysis done using an actuated spray combustion model revealed that the combustion response times of these fuels were similar. Combined with experimental spray characterizations, this suggested that controller performance should remain effective with various alternative fuels. Active control experiments validated this analysis while demonstrating 50-70% reduction in the peak spectral amplitude. A new model augmentor was built and tested for combustion dynamics using schlieren and chemiluminescence techniques. Novel active control techniques including pulsed air injection were implemented and the results were compared with the pulsed fuel injection approach. The pulsed injection of secondary air worked just as effectively for suppressing the augmentor instability, setting up the possibility of more efficient actuation strategy.

Competing opinions and stubborness: Connecting models to data.

PubMed

Burghardt, Keith; Rand, William; Girvan, Michelle

2016-03-01

We introduce a general contagionlike model for competing opinions that includes dynamic resistance to alternative opinions. We show that this model can describe candidate vote distributions, spatial vote correlations, and a slow approach to opinion consensus with sensible parameter values. These empirical properties of large group dynamics, previously understood using distinct models, may be different aspects of human behavior that can be captured by a more unified model, such as the one introduced in this paper.

Populational Growth Models Proportional to Beta Densities with Allee Effect

NASA Astrophysics Data System (ADS)

Aleixo, Sandra M.; Rocha, J. Leonel; Pestana, Dinis D.

2009-05-01

We consider populations growth models with Allee effect, proportional to beta densities with shape parameters p and 2, where the dynamical complexity is related with the Malthusian parameter r. For p>2, these models exhibit a population dynamics with natural Allee effect. However, in the case of 1

In Silico Analysis of the Regulation of the Photosynthetic Electron Transport Chain in C3 Plants1[OPEN

PubMed Central

Kramer, David M.

2018-01-01

We present a new simulation model of the reactions in the photosynthetic electron transport chain of C3 species. We show that including recent insights about the regulation of the thylakoid proton motive force, ATP/NADPH balancing mechanisms (cyclic and noncyclic alternative electron transport), and regulation of Rubisco activity leads to emergent behaviors that may affect the operation and regulation of photosynthesis under different dynamic environmental conditions. The model was parameterized with experimental results in the literature, with a focus on Arabidopsis (Arabidopsis thaliana). A dataset was constructed from multiple sources, including measurements of steady-state and dynamic gas exchange, chlorophyll fluorescence, and absorbance spectroscopy under different light intensities and CO2, to test predictions of the model under different experimental conditions. Simulations suggested that there are strong interactions between cyclic and noncyclic alternative electron transport and that an excess capacity for alternative electron transport is required to ensure adequate redox state and lumen pH. Furthermore, the model predicted that, under specific conditions, reduction of ferredoxin by plastoquinol is possible after a rapid increase in light intensity. Further analysis also revealed that the relationship between ATP synthesis and proton motive force was highly regulated by the concentrations of ATP, ADP, and inorganic phosphate, and this facilitated an increase in nonphotochemical quenching and proton motive force under conditions where metabolism was limiting, such as low CO2, high light intensity, or combined high CO2 and high light intensity. The model may be used as an in silico platform for future research on the regulation of photosynthetic electron transport. PMID:28924017

A Conceptual Model for Solving Percent Problems.

ERIC Educational Resources Information Center

Bennett, Albert B., Jr.; Nelson, L. Ted

1994-01-01

Presents an alternative method to teaching percent problems which uses a 10x10 grid to help students visualize percents. Offers a means of representing information and suggests different approaches for finding solutions. Includes reproducible student worksheet. (MKR)

Ignition of Hydrogen Balloons by Model-Rocket-Engine Igniters.

ERIC Educational Resources Information Center

Hartman, Nicholas T.

2003-01-01

Describes an alternative method for exploding hydrogen balloons as a classroom demonstration. Uses the method of igniting the balloons via an electronic match. Includes necessary materials to conduct the demonstration and discusses potential hazards. (SOE)

Complex-envelope alternating-direction-implicit FDTD method for simulating active photonic devices with semiconductor/solid-state media.

PubMed

Singh, Gurpreet; Ravi, Koustuban; Wang, Qian; Ho, Seng-Tiong

2012-06-15

A complex-envelope (CE) alternating-direction-implicit (ADI) finite-difference time-domain (FDTD) approach to treat light-matter interaction self-consistently with electromagnetic field evolution for efficient simulations of active photonic devices is presented for the first time (to our best knowledge). The active medium (AM) is modeled using an efficient multilevel system of carrier rate equations to yield the correct carrier distributions, suitable for modeling semiconductor/solid-state media accurately. To include the AM in the CE-ADI-FDTD method, a first-order differential system involving CE fields in the AM is first set up. The system matrix that includes AM parameters is then split into two time-dependent submatrices that are then used in an efficient ADI splitting formula. The proposed CE-ADI-FDTD approach with AM takes 22% of the time as the approach of the corresponding explicit FDTD, as validated by semiconductor microdisk laser simulations.

Evaluation of the Navys Sea/Shore Flow Policy

DTIC Science & Technology

2016-06-01

CNA developed an independent Discrete -Event Simulation model to evaluate and assess the effect of alternative sea/shore flow policies. In this study...remains, even if the system is optimized. In building a Discrete -Event Simulation model, we discovered key factors that should be included in the... Discrete -Event Simulation model to evaluate the impact of sea/shore flow policy (the DES-SSF model) and compared the results with the SSFM for one

Forest management under uncertainty for multiple bird population objectives

USGS Publications Warehouse

Moore, C.T.; Plummer, W.T.; Conroy, M.J.; Ralph, C. John; Rich, Terrell D.

2005-01-01

We advocate adaptive programs of decision making and monitoring for the management of forest birds when responses by populations to management, and particularly management trade-offs among populations, are uncertain. Models are necessary components of adaptive management. Under this approach, uncertainty about the behavior of a managed system is explicitly captured in a set of alternative models. The models generate testable predictions about the response of populations to management, and monitoring data provide the basis for assessing these predictions and informing future management decisions. To illustrate these principles, we examine forest management at the Piedmont National Wildlife Refuge, where management attention is focused on the recovery of the Red-cockaded Woodpecker (Picoides borealis) population. However, managers are also sensitive to the habitat needs of many non-target organisms, including Wood Thrushes (Hylocichla mustelina) and other forest interior Neotropical migratory birds. By simulating several management policies on a set of-alternative forest and bird models, we found a decision policy that maximized a composite response by woodpeckers and Wood Thrushes despite our complete uncertainty regarding system behavior. Furthermore, we used monitoring data to update our measure of belief in each alternative model following one cycle of forest management. This reduction of uncertainty translates into a reallocation of model influence on the choice of optimal decision action at the next decision opportunity.

Parameter Estimation of Computationally Expensive Watershed Models Through Efficient Multi-objective Optimization and Interactive Decision Analytics

NASA Astrophysics Data System (ADS)

Akhtar, Taimoor; Shoemaker, Christine

2016-04-01

Watershed model calibration is inherently a multi-criteria problem. Conflicting trade-offs exist between different quantifiable calibration criterions indicating the non-existence of a single optimal parameterization. Hence, many experts prefer a manual approach to calibration where the inherent multi-objective nature of the calibration problem is addressed through an interactive, subjective, time-intensive and complex decision making process. Multi-objective optimization can be used to efficiently identify multiple plausible calibration alternatives and assist calibration experts during the parameter estimation process. However, there are key challenges to the use of multi objective optimization in the parameter estimation process which include: 1) multi-objective optimization usually requires many model simulations, which is difficult for complex simulation models that are computationally expensive; and 2) selection of one from numerous calibration alternatives provided by multi-objective optimization is non-trivial. This study proposes a "Hybrid Automatic Manual Strategy" (HAMS) for watershed model calibration to specifically address the above-mentioned challenges. HAMS employs a 3-stage framework for parameter estimation. Stage 1 incorporates the use of an efficient surrogate multi-objective algorithm, GOMORS, for identification of numerous calibration alternatives within a limited simulation evaluation budget. The novelty of HAMS is embedded in Stages 2 and 3 where an interactive visual and metric based analytics framework is available as a decision support tool to choose a single calibration from the numerous alternatives identified in Stage 1. Stage 2 of HAMS provides a goodness-of-fit measure / metric based interactive framework for identification of a small subset (typically less than 10) of meaningful and diverse set of calibration alternatives from the numerous alternatives obtained in Stage 1. Stage 3 incorporates the use of an interactive visual analytics framework for decision support in selection of one parameter combination from the alternatives identified in Stage 2. HAMS is applied for calibration of flow parameters of a SWAT model, (Soil and Water Assessment Tool) designed to simulate flow in the Cannonsville watershed in upstate New York. Results from the application of HAMS to Cannonsville indicate that efficient multi-objective optimization and interactive visual and metric based analytics can bridge the gap between the effective use of both automatic and manual strategies for parameter estimation of computationally expensive watershed models.

Scripting MODFLOW Model Development Using Python and FloPy.

PubMed

Bakker, M; Post, V; Langevin, C D; Hughes, J D; White, J T; Starn, J J; Fienen, M N

2016-09-01

Graphical user interfaces (GUIs) are commonly used to construct and postprocess numerical groundwater flow and transport models. Scripting model development with the programming language Python is presented here as an alternative approach. One advantage of Python is that there are many packages available to facilitate the model development process, including packages for plotting, array manipulation, optimization, and data analysis. For MODFLOW-based models, the FloPy package was developed by the authors to construct model input files, run the model, and read and plot simulation results. Use of Python with the available scientific packages and FloPy facilitates data exploration, alternative model evaluations, and model analyses that can be difficult to perform with GUIs. Furthermore, Python scripts are a complete, transparent, and repeatable record of the modeling process. The approach is introduced with a simple FloPy example to create and postprocess a MODFLOW model. A more complicated capture-fraction analysis with a real-world model is presented to demonstrate the types of analyses that can be performed using Python and FloPy. © 2016, National Ground Water Association.

Testing the Construct Validity of Proposed Criteria for "DSM-5" Autism Spectrum Disorder

ERIC Educational Resources Information Center

Mandy, William P. L.; Charman, Tony; Skuse, David H.

2012-01-01

Objective: To use confirmatory factor analysis to test the construct validity of the proposed "DSM-5" symptom model of autism spectrum disorder (ASD), in comparison to alternative models, including that described in "DSM-IV-TR." Method: Participants were 708 verbal children and young persons (mean age, 9.5 years) with mild to severe autistic…

A review of the solar array manufacturing industry costing standards

NASA Technical Reports Server (NTRS)

1977-01-01

The solar array manufacturing industry costing standards model is designed to compare the cost of producing solar arrays using alternative manufacturing processes. Constructive criticism of the methodology used is intended to enhance its implementation as a practical design tool. Three main elements of the procedure include workbook format and presentation, theoretical model validity and standard financial parameters.

Making Meaningful Measurement in Survey Research: A Demonstration of the Utility of the Rasch Model. IR Applications. Volume 28

ERIC Educational Resources Information Center

Royal, Kenneth D.

2010-01-01

Quality measurement is essential in every form of research, including institutional research and assessment. This paper addresses the erroneous assumptions institutional researchers often make with regard to survey research and provides an alternative method to producing more valid and reliable measures. Rasch measurement models are discussed and…

Integrating modeling, monitoring, and management to reduce critical uncertainties in water resource decision making.

PubMed

Peterson, James T; Freeman, Mary C

2016-12-01

Stream ecosystems provide multiple, valued services to society, including water supply, waste assimilation, recreation, and habitat for diverse and productive biological communities. Managers striving to sustain these services in the face of changing climate, land uses, and water demands need tools to assess the potential effectiveness of alternative management actions, and often, the resulting tradeoffs between competing objectives. Integrating predictive modeling with monitoring data in an adaptive management framework provides a process by which managers can reduce model uncertainties and thus improve the scientific bases for subsequent decisions. We demonstrate an integration of monitoring data with a dynamic, metapopulation model developed to assess effects of streamflow alteration on fish occupancy in a southeastern US stream system. Although not extensive (collected over three years at nine sites), the monitoring data allowed us to assess and update support for alternative population dynamic models using model probabilities and Bayes rule. We then use the updated model weights to estimate the effects of water withdrawal on stream fish communities and demonstrate how feedback in the form of monitoring data can be used to improve water resource decision making. We conclude that investment in more strategic monitoring, guided by a priori model predictions under alternative hypotheses and an adaptive sampling design, could substantially improve the information available to guide decision-making and management for ecosystem services from lotic systems. Published by Elsevier Ltd.

Risk-based cost-benefit analysis for evaluating microbial risk mitigation in a drinking water system.

PubMed

Bergion, Viktor; Lindhe, Andreas; Sokolova, Ekaterina; Rosén, Lars

2018-04-01

Waterborne outbreaks of gastrointestinal diseases can cause large costs to society. Risk management needs to be holistic and transparent in order to reduce these risks in an effective manner. Microbial risk mitigation measures in a drinking water system were investigated using a novel approach combining probabilistic risk assessment and cost-benefit analysis. Lake Vomb in Sweden was used to exemplify and illustrate the risk-based decision model. Four mitigation alternatives were compared, where the first three alternatives, A1-A3, represented connecting 25, 50 and 75%, respectively, of on-site wastewater treatment systems in the catchment to the municipal wastewater treatment plant. The fourth alternative, A4, represented installing a UV-disinfection unit in the drinking water treatment plant. Quantitative microbial risk assessment was used to estimate the positive health effects in terms of quality adjusted life years (QALYs), resulting from the four mitigation alternatives. The health benefits were monetised using a unit cost per QALY. For each mitigation alternative, the net present value of health and environmental benefits and investment, maintenance and running costs was calculated. The results showed that only A4 can reduce the risk (probability of infection) below the World Health Organization guidelines of 10 -4 infections per person per year (looking at the 95th percentile). Furthermore, all alternatives resulted in a negative net present value. However, the net present value would be positive (looking at the 50 th percentile using a 1% discount rate) if non-monetised benefits (e.g. increased property value divided evenly over the studied time horizon and reduced microbial risks posed to animals), estimated at 800-1200 SEK (€100-150) per connected on-site wastewater treatment system per year, were included. This risk-based decision model creates a robust and transparent decision support tool. It is flexible enough to be tailored and applied to local settings of drinking water systems. The model provides a clear and holistic structure for decisions related to microbial risk mitigation. To improve the decision model, we suggest to further develop the valuation and monetisation of health effects and to refine the propagation of uncertainties and variabilities between the included methods. Copyright © 2018 Elsevier Ltd. All rights reserved.

Student midwives' perceptions on the organisation of maternity care and alternative maternity care models in the Netherlands - a qualitative study.

PubMed

Warmelink, J Catja; de Cock, T Paul; Combee, Yvonne; Rongen, Marloes; Wiegers, Therese A; Hutton, Eileen K

2017-01-11

A major change in the organisation of maternity care in the Netherlands is under consideration, going from an echelon system where midwives provide primary care in the community and refer to obstetricians for secondary and tertiary care, to a more integrated maternity care system involving midwives and obstetricians at all care levels. Student midwives are the future maternity care providers and they may be entering into a changing maternity care system, so inclusion of their views in the discussion is relevant. This study aimed to explore student midwives' perceptions on the current organisation of maternity care and alternative maternity care models, including integrated care. This qualitative study was based on the interpretivist/constructivist paradigm, using a grounded theory design. Interviews and focus groups with 18 female final year student midwives of the Midwifery Academy Amsterdam Groningen (AVAG) were held on the basis of a topic list, then later transcribed, coded and analysed. Students felt that inevitably there will be a change in the organisation of maternity care, and they were open to change. Participants indicated that good collaboration between professions, including a shared system of maternity notes and guidelines, and mutual trust and respect were important aspects of any alternative model. The students indicated that client-centered care and the safeguarding of the physiological, normalcy approach to pregnancy and birth should be maintained in any alternative model. Students expressed worries that the role of midwives in intrapartum care could become redundant, and thus they are motivated to take on new roles and competencies, so they can ensure their own role in intrapartum care. Final year student midwives recognise that change in the organisation of maternity care is inevitable and have an open attitude towards changes if they include good collaboration, client-centred care and safeguards for normal physiological birth. The graduating midwives are motivated to undertake an expanded intrapartum skill set. It can be important to involve students' views in the discussion, because they are the future maternity care providers.

Evaluating Training.

ERIC Educational Resources Information Center

Brethower, Karen S.; Rummler, Geary A.

1979-01-01

Presents general systems models (ballistic system, guided system, and adaptive system) and an evaluation matrix to help in examining training evaluation alternatives and in deciding what evaluation is appropriate. Includes some guidelines for conducting evaluation studies using four designs (control group, reversal, multiple baseline, and…

The Family in Search of a Future: Alternate Models for Moderns

ERIC Educational Resources Information Center

Hamil, Ralph

1971-01-01

The increase of divorce and sexuality outside marriage has challenged the traditional institution of marriage. Fifteen experts offer provocative suggestions of what might replace it, including, possibly, polyandry, student marriages, polygamy, and group sex. (Author/CJ)

ADOT state-specific crash prediction models : an Arizona needs study.

DOT National Transportation Integrated Search

2016-12-01

The predictive method in the Highway Safety Manual (HSM) includes a safety performance function (SPF), : crash modification factors (CMFs), and a local calibration factor (C), if available. Two alternatives exist for : applying the HSM prediction met...

Knowledge Acquisition Methods for the IHDS Diagnostic Review Expert System

DOT National Transportation Integrated Search

1997-12-01

The Federal Highway Administration's Interactive Highway Safety Design Model (IHSDM) is a suite of CADD-compatible programs that highway designers can use to evaluate the safety effects of various design alternatives. The IHSDM will include a Policy ...

A Rule-Based Policy-Level Model of Nonsuperpower Behavior in Strategic Conflicts.

DTIC Science & Technology

1982-12-01

a mechanism. The human mind tends to work linearly and to focus implicitly on a few variables. Experience results in subconscious models with far...which is slower. Alternatives to the current ROSIE implementation include reprogramming Scenario Agent in the C language (the language used for the Red...perception, opportunity perception, opportunity response, and assertiveness. As rules are refined, maintenance and reprogramming of the model will be required

Open Genetic Code: on open source in the life sciences.

PubMed

Deibel, Eric

2014-01-01

The introduction of open source in the life sciences is increasingly being suggested as an alternative to patenting. This is an alternative, however, that takes its shape at the intersection of the life sciences and informatics. Numerous examples can be identified wherein open source in the life sciences refers to access, sharing and collaboration as informatic practices. This includes open source as an experimental model and as a more sophisticated approach of genetic engineering. The first section discusses the greater flexibly in regard of patenting and the relationship to the introduction of open source in the life sciences. The main argument is that the ownership of knowledge in the life sciences should be reconsidered in the context of the centrality of DNA in informatic formats. This is illustrated by discussing a range of examples of open source models. The second part focuses on open source in synthetic biology as exemplary for the re-materialization of information into food, energy, medicine and so forth. The paper ends by raising the question whether another kind of alternative might be possible: one that looks at open source as a model for an alternative to the commodification of life that is understood as an attempt to comprehensively remove the restrictions from the usage of DNA in any of its formats.

An Enhanced Adaptive Management Approach for Remediation of Legacy Mercury in the South River

PubMed Central

Foran, Christy M.; Baker, Kelsie M.; Grosso, Nancy R.; Linkov, Igor

2015-01-01

Uncertainties about future conditions and the effects of chosen actions, as well as increasing resource scarcity, have been driving forces in the utilization of adaptive management strategies. However, many applications of adaptive management have been criticized for a number of shortcomings, including a limited ability to learn from actions and a lack of consideration of stakeholder objectives. To address these criticisms, we supplement existing adaptive management approaches with a decision-analytical approach that first informs the initial selection of management alternatives and then allows for periodic re-evaluation or phased implementation of management alternatives based on monitoring information and incorporation of stakeholder values. We describe the application of this enhanced adaptive management (EAM) framework to compare remedial alternatives for mercury in the South River, based on an understanding of the loading and behavior of mercury in the South River near Waynesboro, VA. The outcomes show that the ranking of remedial alternatives is influenced by uncertainty in the mercury loading model, by the relative importance placed on different criteria, and by cost estimates. The process itself demonstrates that a decision model can link project performance criteria, decision-maker preferences, environmental models, and short- and long-term monitoring information with management choices to help shape a remediation approach that provides useful information for adaptive, incremental implementation. PMID:25665032

Albumin infusion in patients undergoing large-volume paracentesis: a meta-analysis of randomized trials.

PubMed

Bernardi, Mauro; Caraceni, Paolo; Navickis, Roberta J; Wilkes, Mahlon M

2012-04-01

Albumin infusion reduces the incidence of postparacentesis circulatory dysfunction among patients with cirrhosis and tense ascites, as compared with no treatment. Treatment alternatives to albumin, such as artificial colloids and vasoconstrictors, have been widely investigated. The aim of this meta-analysis was to determine whether morbidity and mortality differ between patients receiving albumin versus alternative treatments. The meta-analysis included randomized trials evaluating albumin infusion in patients with tense ascites. Primary endpoints were postparacentesis circulatory dysfunction, hyponatremia, and mortality. Eligible trials were sought by multiple methods, including computer searches of bibliographic and abstract databases and the Cochrane Library. Results were quantitatively combined under a fixed-effects model. Seventeen trials with 1,225 total patients were included. There was no evidence of heterogeneity or publication bias. Compared with alternative treatments, albumin reduced the incidence of postparacentesis circulatory dysfunction (odds ratio [OR], 0.39; 95% confidence interval [CI], 0.27-0.55). Significant reductions in that complication by albumin were also shown in subgroup analyses versus each of the other volume expanders tested (e.g., dextran, gelatin, hydroxyethyl starch, and hypertonic saline). The occurrence of hyponatremia was also decreased by albumin, compared with alternative treatments (OR, 0.58; 95% CI, 0.39-0.87). In addition, mortality was lower in patients receiving albumin than alternative treatments (OR, 0.64; 95% CI, 0.41-0.98). This meta-analysis provides evidence that albumin reduces morbidity and mortality among patients with tense ascites undergoing large-volume paracentesis, as compared with alternative treatments investigated thus far. Copyright © 2011 American Association for the Study of Liver Diseases.

Critiques of the seismic hypothesis and the vegetation stabilization hypothesis for the formation of Mima mounds along the western coast of the U.S.

NASA Astrophysics Data System (ADS)

Gabet, Emmanuel J.; Burnham, Jennifer L. Horwath; Perron, J. Taylor

2016-09-01

A recent paper published in Geomorphology by Gabet et al. (2014) presents the results of a numerical model supporting the hypothesis that burrowing mammals build Mima mounds - small, densely packed hillocks found primarily in the western United States. The model is based on field observations and produces realistic-looking mounds with spatial distributions similar to real moundfields. Alternative explanations have been proposed for these Mima mounds, including formation by seismic shaking and vegetation-controlled erosion and deposition. In this short communication, we present observations from moundfields in the coastal states of the western U.S. that are incompatible with these alternative theories.

Using the Standard Deviation of a Region of Interest in an Image to Estimate Camera to Emitter Distance

PubMed Central

Cano-García, Angel E.; Lazaro, José Luis; Infante, Arturo; Fernández, Pedro; Pompa-Chacón, Yamilet; Espinoza, Felipe

2012-01-01

In this study, a camera to infrared diode (IRED) distance estimation problem was analyzed. The main objective was to define an alternative to measures depth only using the information extracted from pixel grey levels of the IRED image to estimate the distance between the camera and the IRED. In this paper, the standard deviation of the pixel grey level in the region of interest containing the IRED image is proposed as an empirical parameter to define a model for estimating camera to emitter distance. This model includes the camera exposure time, IRED radiant intensity and the distance between the camera and the IRED. An expression for the standard deviation model related to these magnitudes was also derived and calibrated using different images taken under different conditions. From this analysis, we determined the optimum parameters to ensure the best accuracy provided by this alternative. Once the model calibration had been carried out, a differential method to estimate the distance between the camera and the IRED was defined and applied, considering that the camera was aligned with the IRED. The results indicate that this method represents a useful alternative for determining the depth information. PMID:22778608

Using the standard deviation of a region of interest in an image to estimate camera to emitter distance.

PubMed

Cano-García, Angel E; Lazaro, José Luis; Infante, Arturo; Fernández, Pedro; Pompa-Chacón, Yamilet; Espinoza, Felipe

2012-01-01

In this study, a camera to infrared diode (IRED) distance estimation problem was analyzed. The main objective was to define an alternative to measures depth only using the information extracted from pixel grey levels of the IRED image to estimate the distance between the camera and the IRED. In this paper, the standard deviation of the pixel grey level in the region of interest containing the IRED image is proposed as an empirical parameter to define a model for estimating camera to emitter distance. This model includes the camera exposure time, IRED radiant intensity and the distance between the camera and the IRED. An expression for the standard deviation model related to these magnitudes was also derived and calibrated using different images taken under different conditions. From this analysis, we determined the optimum parameters to ensure the best accuracy provided by this alternative. Once the model calibration had been carried out, a differential method to estimate the distance between the camera and the IRED was defined and applied, considering that the camera was aligned with the IRED. The results indicate that this method represents a useful alternative for determining the depth information.

Testing Multi-Alternative Decision Models with Non-Stationary Evidence

PubMed Central

Tsetsos, Konstantinos; Usher, Marius; McClelland, James L.

2011-01-01

Recent research has investigated the process of integrating perceptual evidence toward a decision, converging on a number of sequential sampling choice models, such as variants of race and diffusion models and the non-linear leaky competing accumulator (LCA) model. Here we study extensions of these models to multi-alternative choice, considering how well they can account for data from a psychophysical experiment in which the evidence supporting each of the alternatives changes dynamically during the trial, in a way that creates temporal correlations. We find that participants exhibit a tendency to choose an alternative whose evidence profile is temporally anti-correlated with (or dissimilar from) that of other alternatives. This advantage of the anti-correlated alternative is well accounted for in the LCA, and provides constraints that challenge several other models of multi-alternative choice. PMID:21603227

Testing multi-alternative decision models with non-stationary evidence.

PubMed

Tsetsos, Konstantinos; Usher, Marius; McClelland, James L

2011-01-01

Recent research has investigated the process of integrating perceptual evidence toward a decision, converging on a number of sequential sampling choice models, such as variants of race and diffusion models and the non-linear leaky competing accumulator (LCA) model. Here we study extensions of these models to multi-alternative choice, considering how well they can account for data from a psychophysical experiment in which the evidence supporting each of the alternatives changes dynamically during the trial, in a way that creates temporal correlations. We find that participants exhibit a tendency to choose an alternative whose evidence profile is temporally anti-correlated with (or dissimilar from) that of other alternatives. This advantage of the anti-correlated alternative is well accounted for in the LCA, and provides constraints that challenge several other models of multi-alternative choice.

FRankenstein becomes a cyborg: the automatic recombination and realignment of fold recognition models in CASP6.

PubMed

Kosinski, Jan; Gajda, Michal J; Cymerman, Iwona A; Kurowski, Michal A; Pawlowski, Marcin; Boniecki, Michal; Obarska, Agnieszka; Papaj, Grzegorz; Sroczynska-Obuchowicz, Paulina; Tkaczuk, Karolina L; Sniezynska, Paulina; Sasin, Joanna M; Augustyn, Anna; Bujnicki, Janusz M; Feder, Marcin

2005-01-01

In the course of CASP6, we generated models for all targets using a new version of the "FRankenstein's monster approach." Previously (in CASP5) we were able to build many very accurate full-atom models by selection and recombination of well-folded fragments obtained from crude fold recognition (FR) results, followed by optimization of the sequence-structure fit and assessment of alternative alignments on the structural level. This procedure was however very arduous, as most of the steps required extensive visual and manual input from the human modeler. Now, we have automated the most tedious steps, such as superposition of alternative models, extraction of best-scoring fragments, and construction of a hybrid "monster" structure, as well as generation of alternative alignments in the regions that remain poorly scored in the refined hybrid model. We have also included the ROSETTA method to construct those parts of the target for which no reasonable structures were generated by FR methods (such as long insertions and terminal extensions). The analysis of successes and failures of the current version of the FRankenstein approach in modeling of CASP6 targets reveals that the considerably streamlined and automated method performs almost as well as the initial, mostly manual version, which suggests that it may be a useful tool for accurate protein structure prediction even in the hands of nonexperts. 2005 Wiley-Liss, Inc.

Pharmaceutical interventions for mitigating an influenza pandemic: modeling the risks and health-economic impacts.

PubMed

Postma, Maarten J; Milne, George; Nelson, E Anthony S; Pyenson, Bruce; Basili, Marcello; Coker, Richard; Oxford, John; Garrison, Louis P

2010-12-01

Model-based analyses built on burden-of-disease and cost-effectiveness theory predict that pharmaceutical interventions may efficiently mitigate both the epidemiologic and economic impact of an influenza pandemic. Pharmaceutical interventions typically encompass the application of (pre)pandemic influenza vaccines, other vaccines (notably pneumococcal), antiviral treatments and other drug treatment (e.g., antibiotics to target potential complications of influenza). However, these models may be too limited to capture the full macro-economic impact of pandemic influenza. The aim of this article is to summarize current health-economic modeling approaches to recognize the strengths and weaknesses of these approaches, and to compare these with more recently proposed alternative methods. We conclude that it is useful, particularly for policy and planning purposes, to extend modeling concepts through the application of alternative approaches, including insurers' risk theories, human capital approaches and sectoral and full macro-economic modeling. This article builds on a roundtable meeting of the Pandemic Influenza Economic Impact Group that was held in Boston, MA, USA, in December 2008.

Assessing the Health of LiFePO4 Traction Batteries through Monotonic Echo State Networks

PubMed Central

Anseán, David; Otero, José; Couso, Inés

2017-01-01

A soft sensor is presented that approximates certain health parameters of automotive rechargeable batteries from on-vehicle measurements of current and voltage. The sensor is based on a model of the open circuit voltage curve. This last model is implemented through monotonic neural networks and estimate over-potentials arising from the evolution in time of the Lithium concentration in the electrodes of the battery. The proposed soft sensor is able to exploit the information contained in operational records of the vehicle better than the alternatives, this being particularly true when the charge or discharge currents are between moderate and high. The accuracy of the neural model has been compared to different alternatives, including data-driven statistical models, first principle-based models, fuzzy observers and other recurrent neural networks with different topologies. It is concluded that monotonic echo state networks can outperform well established first-principle models. The algorithms have been validated with automotive Li-FePO4 cells. PMID:29267219

Medicare Program; Merit-Based Incentive Payment System (MIPS) and Alternative Payment Model (APM) Incentive Under the Physician Fee Schedule, and Criteria for Physician-Focused Payment Models. Final rule with comment period.

PubMed

2016-11-04

The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) repeals the Medicare sustainable growth rate (SGR) methodology for updates to the physician fee schedule (PFS) and replaces it with a new approach to payment called the Quality Payment Program that rewards the delivery of high-quality patient care through two avenues: Advanced Alternative Payment Models (Advanced APMs) and the Merit-based Incentive Payment System (MIPS) for eligible clinicians or groups under the PFS. This final rule with comment period establishes incentives for participation in certain alternative payment models (APMs) and includes the criteria for use by the Physician-Focused Payment Model Technical Advisory Committee (PTAC) in making comments and recommendations on physician-focused payment models (PFPMs). Alternative Payment Models are payment approaches, developed in partnership with the clinician community, that provide added incentives to deliver high-quality and cost-efficient care. APMs can apply to a specific clinical condition, a care episode, or a population. This final rule with comment period also establishes the MIPS, a new program for certain Medicare-enrolled practitioners. MIPS will consolidate components of three existing programs, the Physician Quality Reporting System (PQRS), the Physician Value-based Payment Modifier (VM), and the Medicare Electronic Health Record (EHR) Incentive Program for Eligible Professionals (EPs), and will continue the focus on quality, cost, and use of certified EHR technology (CEHRT) in a cohesive program that avoids redundancies. In this final rule with comment period we have rebranded key terminology based on feedback from stakeholders, with the goal of selecting terms that will be more easily identified and understood by our stakeholders.

Development of Electronic Load Controllers for Free-Piston Stirling Convertors Aided by Stirling Simulation Model

NASA Technical Reports Server (NTRS)

Regan, Timothy F.

2004-01-01

The free-piston Stirling convertor end-to-end modeling effort at the NASA Glenn Research Center has produced a software-based test bed in which free-piston Stirling convertors can be simulated and evaluated. The simulation model includes all the components of the convertor: the Stirling cycle engine, heat source, linear alternator, controller, and load. So far, it has been used in evaluating the performance of electronic controller designs. Three different controller design concepts were simulated using the model: 1) Controllers with parasitic direct current loading. 2) Controllers with parasitic alternating current loading. 3) Controllers that maintain a reference current. The free-piston Stirling convertor is an electromechanical device that operates at resonance. It is the function of the electronic load controller to ensure that the electrical load seen by the machine is always great enough to keep the amplitude of the piston and alternator oscillation at the rated value. This is done by regulating the load on the output bus. The controller monitors the instantaneous voltage, regulating it by switching loads called parasitic loads onto the bus whenever the bus voltage is too high and removing them whenever the voltage is too low. In the first type of controller, the monitor-ing and switching are done on the direct-current (dc) bus. In the second type, the alternating current bus is used. The model allows designers to test a controller concept before investing time in hardware. The simulation code used to develop the model also offers detailed models of digital and analog electronic components so that the resulting designs are realistic enough to translate directly into hardware circuits.

Counseling Model Application: A Student Career Development Guidance for Decision Maker and Consultation

NASA Astrophysics Data System (ADS)

Irwan; Gustientiedina; Sunarti; Desnelita, Yenny

2017-12-01

The purpose of this study is to design a counseling model application for a decision-maker and consultation system. This application as an alternative guidance and individual career development for students, that include career knowledge, planning and alternative options from an expert tool based on knowledge and rule to provide the solutions on student’s career decisions. This research produces a counseling model application to obtain the important information about student career development and facilitating individual student’s development through the service form, to connect their plan with their career according to their talent, interest, ability, knowledge, personality and other supporting factors. This application model can be used as tool to get information faster and flexible for the student’s guidance and counseling. So, it can help students in doing selection and making decision that appropriate with their choice of works.

Muscular dystrophy summer camp: a case study of a non-traditional level I fieldwork using a collaborative supervision model.

PubMed

Provident, Ingrid M; Colmer, Maria A

2013-01-01

A shortage of traditional medical fieldwork placements has been reported in the United States. Alternative settings are being sought to meet the Accreditation Standards for Level I fieldwork. This study was designed to examine and report the outcomes of an alternative pediatric camp setting, using a group model of supervision to fulfill the requirements for Level I fieldwork. Thirty-seven students from two Pennsylvania OT schools. Two cohorts of students were studied over a two year period using multiple methods of retrospective review and data collection. Students supervised in a group model experienced positive outcomes, including opportunities to deliver client centered care, and understanding the role of caregiving for children with disabilities. The use of a collaborative model of fieldwork education at a camp setting has resulted in a viable approach for the successful attainment of Level I fieldwork objectives for multiple students under a single supervisor.

Adaptive Value Normalization in the Prefrontal Cortex Is Reduced by Memory Load.

PubMed

Holper, L; Van Brussel, L D; Schmidt, L; Schulthess, S; Burke, C J; Louie, K; Seifritz, E; Tobler, P N

2017-01-01

Adaptation facilitates neural representation of a wide range of diverse inputs, including reward values. Adaptive value coding typically relies on contextual information either obtained from the environment or retrieved from and maintained in memory. However, it is unknown whether having to retrieve and maintain context information modulates the brain's capacity for value adaptation. To address this issue, we measured hemodynamic responses of the prefrontal cortex (PFC) in two studies on risky decision-making. In each trial, healthy human subjects chose between a risky and a safe alternative; half of the participants had to remember the risky alternatives, whereas for the other half they were presented visually. The value of safe alternatives varied across trials. PFC responses adapted to contextual risk information, with steeper coding of safe alternative value in lower-risk contexts. Importantly, this adaptation depended on working memory load, such that response functions relating PFC activity to safe values were steeper with presented versus remembered risk. An independent second study replicated the findings of the first study and showed that similar slope reductions also arose when memory maintenance demands were increased with a secondary working memory task. Formal model comparison showed that a divisive normalization model fitted effects of both risk context and working memory demands on PFC activity better than alternative models of value adaptation, and revealed that reduced suppression of background activity was the critical parameter impairing normalization with increased memory maintenance demand. Our findings suggest that mnemonic processes can constrain normalization of neural value representations.

The DSM-5 alternative model of personality disorders from the perspective of adult attachment: a study in community-dwelling adults.

PubMed

Fossati, Andrea; Krueger, Robert F; Markon, Kristian E; Borroni, Serena; Maffei, Cesare; Somma, Antonella

2015-04-01

To assess how the maladaptive personality domains and facets that were included in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Alternative Model of Personality Disorders relate to adult attachment styles, 480 Italian nonclinical adults were administered the Personality Inventory for DSM-5 (PID-5) and the Attachment Style Questionnaire (ASQ). To evaluate the uniqueness of the associations between the PID-5 scales and the ASQ scales, the participants were also administered the Big Five Inventory (BFI). Multiple regression analyses showed that the ASQ scales significantly predicted both PID-5 domain scales and BFI scales; however, the relationships were different both qualitatively and quantitatively. With the exception of the PID-5 risk taking scale (adjusted R(2) = 0.02), all other PID-5 trait scales were significantly predicted by the ASQ scales, median adjusted R(2) value = 0.25, all ps < 0.001. Our findings suggest that the maladaptive personality domains and traits listed in the DSM-5 Alternative Model of Personality Disorders show meaningful associations with adult attachment styles.

Portfolios: An Alternative Method of Student and Program Assessment

PubMed Central

Hannam, Susan E.

1995-01-01

The use of performance-based evaluation and alternative assessment techniques has become essential for curriculum programs seeking Commission of Accreditation of Allied Health Education Programs (CAAHEP) accreditation. In athletic training education, few assessment models exist to assess student performance over the entire course of their educational program. This article describes a model of assessment-a student athletic training portfolio of “best works.” The portfolio can serve as a method to assess student development and to assess program effectiveness. The goals of the program include purposes specific to the five NATA performance domains. In addition, four types of portfolio evidence are described: artifacts, attestations, productions, and reproductions. Quality assignments and projects completed by students as they progress through a six-semester program are identified relative to the type of evidence and the domain(s) they represent. The portfolio assists with student development, provides feedback for curriculum planning, allows for student/faculty collaboration and “coaching” of the student, and assists with job searching. This information will serve as a useful model for those athletic training programs looking for an alternative method of assessing student and program outcomes. PMID:16558359

Resurgence of target responding does not exceed increases in inactive responding in a forced-choice alternative reinforcement procedure in humans

PubMed Central

Sweeney, Mary M.; Shahan, Timothy A.

2016-01-01

Resurgence following removal of alternative reinforcement has been studied in non-human animals, children with developmental disabilities, and typically functioning adults. Adult human laboratory studies have included responses without a controlled history of reinforcement, included only two response options, or involved extensive training. Arbitrary responses allow for control over history of reinforcement. Including an inactive response never associated with reinforcement allows the conclusion that resurgence exceeds extinction-induced variability. Although procedures with extensive training produce reliable resurgence, a brief procedure with the same experimental control would allow more efficient examination of resurgence in adult humans. We tested the acceptability of a brief, single-session, three-alternative forced-choice procedure as a model of resurgence in undergraduates. Selecting a shape was the target response (reinforced in Phase I), selecting another shape was the alternative response (reinforced in Phase II), and selecting a third shape was never reinforced. Despite manipulating number of trials and probability of reinforcement, resurgence of the target response did not consistently exceed increases in the inactive response. Our findings reiterate the importance of an inactive control response and call for reexamination of resurgence studies using only two response options. We discuss potential approaches to generate an acceptable, brief human laboratory resurgence procedure. PMID:26724752

Alternative Polyadenylation in Human Diseases

PubMed Central

Chang, Jae-Woong; Yeh, Hsin-Sung

2017-01-01

Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression. Alternative polyadenylation (APA) plays an important role for cell growth, proliferation, and differentiation. In this review, we discuss the functions of APA related with various physiological conditions including cellular metabolism, mRNA processing, and protein diversity in a variety of disease models. We also discuss the molecular mechanisms underlying APA regulation, such as variations in the concentration of mRNA processing factors and RNA-binding proteins, as well as global transcriptome changes under cellular signaling pathway. PMID:29271615

Extracting the Evaluations of Stereotypes: Bi-factor Model of the Stereotype Content Structure

PubMed Central

Sayans-Jiménez, Pablo; Cuadrado, Isabel; Rojas, Antonio J.; Barrada, Juan R.

2017-01-01

Stereotype dimensions—competence, morality and sociability—are fundamental to studying the perception of other groups. These dimensions have shown moderate/high positive correlations with each other that do not reflect the theoretical expectations. The explanation for this (e.g., halo effect) undervalues the utility of the shared variance identified. In contrast, in this work we propose that this common variance could represent the global evaluation of the perceived group. Bi-factor models are proposed to improve the internal structure and to take advantage of the information representing the shared variance among dimensions. Bi-factor models were compared with first order models and other alternative models in three large samples (300–309 participants). The relationships among the global and specific bi-factor dimensions with a global evaluation dimension (measured through a semantic differential) were estimated. The results support the use of bi-factor models rather than first order models (and other alternative models). Bi-factor models also show a greater utility to directly and more easily explore the stereotype content including its evaluative content. PMID:29085313

Alternate methodologies to experimentally investigate shock initiation properties of explosives

NASA Astrophysics Data System (ADS)

Svingala, Forrest R.; Lee, Richard J.; Sutherland, Gerrit T.; Benjamin, Richard; Boyle, Vincent; Sickels, William; Thompson, Ronnie; Samuels, Phillip J.; Wrobel, Erik; Cornell, Rodger

2017-01-01

Reactive flow models are desired for new explosive formulations early in the development stage. Traditionally, these models are parameterized by carefully-controlled 1-D shock experiments, including gas-gun testing with embedded gauges and wedge testing with explosive plane wave lenses (PWL). These experiments are easy to interpret due to their 1-D nature, but are expensive to perform and cannot be performed at all explosive test facilities. This work investigates alternative methods to probe shock-initiation behavior of new explosives using widely-available pentolite gap test donors and simple time-of-arrival type diagnostics. These experiments can be performed at a low cost at most explosives testing facilities. This allows experimental data to parameterize reactive flow models to be collected much earlier in the development of an explosive formulation. However, the fundamentally 2-D nature of these tests may increase the modeling burden in parameterizing these models and reduce general applicability. Several variations of the so-called modified gap test were investigated and evaluated for suitability as an alternative to established 1-D gas gun and PWL techniques. At least partial agreement with 1-D test methods was observed for the explosives tested, and future work is planned to scope the applicability and limitations of these experimental techniques.

Quantitative structure - mesothelioma potency model ...

EPA Pesticide Factsheets

Cancer potencies of mineral and synthetic elongated particle (EP) mixtures, including asbestos fibers, are influenced by changes in fiber dose composition, bioavailability, and biodurability in combination with relevant cytotoxic dose-response relationships. A unique and comprehensive rat intra-pleural (IP) dose characterization data set with a wide variety of EP size, shape, crystallographic, chemical, and bio-durability properties facilitated extensive statistical analyses of 50 rat IP exposure test results for evaluation of alternative dose pleural mesothelioma response models. Utilizing logistic regression, maximum likelihood evaluations of thousands of alternative dose metrics based on hundreds of individual EP dimensional variations within each test sample, four major findings emerged: (1) data for simulations of short-term EP dose changes in vivo (mild acid leaching) provide superior predictions of tumor incidence compared to non-acid leached data; (2) sum of the EP surface areas (ÓSA) from these mildly acid-leached samples provides the optimum holistic dose response model; (3) progressive removal of dose associated with very short and/or thin EPs significantly degrades resultant ÓEP or ÓSA dose-based predictive model fits, as judged by Akaike’s Information Criterion (AIC); and (4) alternative, biologically plausible model adjustments provide evidence for reduced potency of EPs with length/width (aspect) ratios 80 µm. Regar

Codeswitching Worldwide II. Trends in Linguistics: Studies and Monographs 126.

ERIC Educational Resources Information Center

Jacobson, Rodolfo, Ed.

This edited volume includes the following chapters: "The Matrix Language Frame Model: Development and Responses" (Carol Myers-Scotton); "Language Alternation: The Third Kind of Codeswitching Mechanism" (Rodolfo Jacobson); "Contrastive Sociolinguistics: Borrowed and Codeswitched Past Participles in Romance-Germanic Language…

Preparing Healthy Young Children for Hospitalization: A Rationale and Proposal.

ERIC Educational Resources Information Center

Poster, Elizabeth C.

1984-01-01

Proposes a precrisis curriculum for nursery and elementary schools to prepare healthy young children for hospitalization as an alternative to current preadmission preparation programs. Key elements include such stress-immunization techniques as systematic desensitization, modeling, and rehearsal. (AS)

Uniform California earthquake rupture forecast, version 3 (UCERF3): the time-independent model

USGS Publications Warehouse

Field, Edward H.; Biasi, Glenn P.; Bird, Peter; Dawson, Timothy E.; Felzer, Karen R.; Jackson, David D.; Johnson, Kaj M.; Jordan, Thomas H.; Madden, Christopher; Michael, Andrew J.; Milner, Kevin R.; Page, Morgan T.; Parsons, Thomas; Powers, Peter M.; Shaw, Bruce E.; Thatcher, Wayne R.; Weldon, Ray J.; Zeng, Yuehua; ,

2013-01-01

In this report we present the time-independent component of the Uniform California Earthquake Rupture Forecast, Version 3 (UCERF3), which provides authoritative estimates of the magnitude, location, and time-averaged frequency of potentially damaging earthquakes in California. The primary achievements have been to relax fault segmentation assumptions and to include multifault ruptures, both limitations of the previous model (UCERF2). The rates of all earthquakes are solved for simultaneously, and from a broader range of data, using a system-level "grand inversion" that is both conceptually simple and extensible. The inverse problem is large and underdetermined, so a range of models is sampled using an efficient simulated annealing algorithm. The approach is more derivative than prescriptive (for example, magnitude-frequency distributions are no longer assumed), so new analysis tools were developed for exploring solutions. Epistemic uncertainties were also accounted for using 1,440 alternative logic tree branches, necessitating access to supercomputers. The most influential uncertainties include alternative deformation models (fault slip rates), a new smoothed seismicity algorithm, alternative values for the total rate of M≥5 events, and different scaling relationships, virtually all of which are new. As a notable first, three deformation models are based on kinematically consistent inversions of geodetic and geologic data, also providing slip-rate constraints on faults previously excluded because of lack of geologic data. The grand inversion constitutes a system-level framework for testing hypotheses and balancing the influence of different experts. For example, we demonstrate serious challenges with the Gutenberg-Richter hypothesis for individual faults. UCERF3 is still an approximation of the system, however, and the range of models is limited (for example, constrained to stay close to UCERF2). Nevertheless, UCERF3 removes the apparent UCERF2 overprediction of M6.5–7 earthquake rates and also includes types of multifault ruptures seen in nature. Although UCERF3 fits the data better than UCERF2 overall, there may be areas that warrant further site-specific investigation. Supporting products may be of general interest, and we list key assumptions and avenues for future model improvements.

Alternatives Analysis for the Resumption of Transient Testing Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee Nelson

2013-11-01

An alternatives analysis was performed for resumption of transient testing. The analysis considered eleven alternatives – including both US international facilities. A screening process was used to identify two viable alternatives from the original eleven. In addition, the alternatives analysis includes a no action alternative as required by the National Environmental Policy Act (NEPA). The alternatives considered in this analysis included: 1. Restart the Transient Reactor Test Facility (TREAT) 2. Modify the Annular Core Research Reactor (ACRR) which includes construction of a new hot cell and installation of a new hodoscope. 3. No Action

Understanding the Impact of Organizational Differentiation in High-Poverty Schools with Alternative Models of Title I Service Delivery.

ERIC Educational Resources Information Center

Meyer, Stephen J.

American public schools historically have used a range of differentiating mechanisms to meet the needs of diverse groups of students. Examples from Title I service delivery include pullout, in-class, add-on, and replacement programs. These models have elements that differentiate the educational experience of Title I students to varying degrees and…

FTM-West Model Results for Selected Fuel Treatment Scenarios

Treesearch

Andrew D. Kramp; Peter J. Ince

2006-01-01

This paper evaluated potential forest product market impacts in the U.S. West of increases in the supply of wood from thinnings to reduce fire hazard. Evaluations are done using the Fuel Treatment Market-West model for a set of hypothetical fuel treatment scenarios, which include stand-density-index (SDI) and thin-from-below (TFB) treatment regimes at alternative...

Computer simulation to predict energy use, greenhouse gas emissions and costs for production of fluid milk using alternative processing methods

USDA-ARS?s Scientific Manuscript database

Computer simulation is a useful tool for benchmarking the electrical and fuel energy consumption and water use in a fluid milk plant. In this study, a computer simulation model of the fluid milk process based on high temperature short time (HTST) pasteurization was extended to include models for pr...

Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens

PubMed Central

López Hernández, Yamilé; Yero, Daniel; Pinos-Rodríguez, Juan M.; Gibert, Isidre

2015-01-01

Biological disease models can be difficult and costly to develop and use on a routine basis. Particularly, in vivo lung infection models performed to study lung pathologies use to be laborious, demand a great time and commonly are associated with ethical issues. When infections in experimental animals are used, they need to be refined, defined, and validated for their intended purpose. Therefore, alternative and easy to handle models of experimental infections are still needed to test the virulence of bacterial lung pathogens. Because non-mammalian models have less ethical and cost constraints as a subjects for experimentation, in some cases would be appropriated to include these models as valuable tools to explore host–pathogen interactions. Numerous scientific data have been argued to the more extensive use of several kinds of alternative models, such as, the vertebrate zebrafish (Danio rerio), and non-vertebrate insects and nematodes (e.g., Caenorhabditis elegans) in the study of diverse infectious agents that affect humans. Here, we review the use of these vertebrate and non-vertebrate models in the study of bacterial agents, which are considered the principal causes of lung injury. Curiously none of these animals have a respiratory system as in air-breathing vertebrates, where respiration takes place in lungs. Despite this fact, with the present review we sought to provide elements in favor of the use of these alternative animal models of infection to reveal the molecular signatures of host–pathogen interactions. PMID:25699030

Psychological and behavioral mechanisms influencing the use of complementary and alternative medicine (CAM) in cancer patients.

PubMed

Hirai, K; Komura, K; Tokoro, A; Kuromaru, T; Ohshima, A; Ito, T; Sumiyoshi, Y; Hyodo, I

2008-01-01

This study explored the psychological and behavioral mechanisms of complementary and alternative medicine (CAM) use in Japanese cancer patients using two applied behavioral models, the transtheoretical model (TTM), and theory of planned behavior (TPB). Questionnaires were distributed to 1100 patients at three cancer treatment facilities in Japan and data on 521 cancer patients were used in the final analysis. The questionnaire included items based on TTM and TPB variables, as well as three psychological batteries. According to the TTM, 88 patients (17%) were in precontemplation, 226 (43%) in contemplation, 33 (6%) in preparation, 71 (14%) in action, and 103 (20%) in maintenance. The model derived from structural equation modeling revealed that the stage of CAM use was significantly affected by the pros, cons, expectation from family, norms of medical staff, use of chemotherapy, period from diagnosis, and place of treatment. The primary factor for the stage of CAM use was the expectation from family. The findings revealed the existence of a number of psychologically induced potential CAM users, and psychological variables including positive attitude for CAM use and perceived family expectation greatly influence CAM use in cancer patients.

Advantages of soft versus hard constraints in self-modeling curve resolution problems. Alternating least squares with penalty functions.

PubMed

Gemperline, Paul J; Cash, Eric

2003-08-15

A new algorithm for self-modeling curve resolution (SMCR) that yields improved results by incorporating soft constraints is described. The method uses least squares penalty functions to implement constraints in an alternating least squares algorithm, including nonnegativity, unimodality, equality, and closure constraints. By using least squares penalty functions, soft constraints are formulated rather than hard constraints. Significant benefits are (obtained using soft constraints, especially in the form of fewer distortions due to noise in resolved profiles. Soft equality constraints can also be used to introduce incomplete or partial reference information into SMCR solutions. Four different examples demonstrating application of the new method are presented, including resolution of overlapped HPLC-DAD peaks, flow injection analysis data, and batch reaction data measured by UV/visible and near-infrared spectroscopy (NIR). Each example was selected to show one aspect of the significant advantages of soft constraints over traditionally used hard constraints. Incomplete or partial reference information into self-modeling curve resolution models is described. The method offers a substantial improvement in the ability to resolve time-dependent concentration profiles from mixture spectra recorded as a function of time.

A mechanism for value-sensitive decision-making.

PubMed

Pais, Darren; Hogan, Patrick M; Schlegel, Thomas; Franks, Nigel R; Leonard, Naomi E; Marshall, James A R

2013-01-01

We present a dynamical systems analysis of a decision-making mechanism inspired by collective choice in house-hunting honeybee swarms, revealing the crucial role of cross-inhibitory 'stop-signalling' in improving the decision-making capabilities. We show that strength of cross-inhibition is a decision-parameter influencing how decisions depend both on the difference in value and on the mean value of the alternatives; this is in contrast to many previous mechanistic models of decision-making, which are typically sensitive to decision accuracy rather than the value of the option chosen. The strength of cross-inhibition determines when deadlock over similarly valued alternatives is maintained or broken, as a function of the mean value; thus, changes in cross-inhibition strength allow adaptive time-dependent decision-making strategies. Cross-inhibition also tunes the minimum difference between alternatives required for reliable discrimination, in a manner similar to Weber's law of just-noticeable difference. Finally, cross-inhibition tunes the speed-accuracy trade-off realised when differences in the values of the alternatives are sufficiently large to matter. We propose that the model, and the significant role of the values of the alternatives, may describe other decision-making systems, including intracellular regulatory circuits, and simple neural circuits, and may provide guidance in the design of decision-making algorithms for artificial systems, particularly those functioning without centralised control.

Multipole models of four-image gravitational lenses with anomalous flux ratios

NASA Astrophysics Data System (ADS)

Congdon, Arthur B.; Keeton, Charles R.

2005-12-01

It has been known for over a decade that many four-image gravitational lenses exhibit anomalous radio flux ratios. These anomalies can be explained by adding a clumpy cold dark matter (CDM) component to the background galactic potential of the lens. As an alternative, Evans & Witt (2003) recently suggested that smooth multipole perturbations provide a reasonable alternative to CDM substructure in some but not all cases. We generalize their method in two ways so as to determine whether multipole models can explain highly anomalous systems. We carry the multipole expansion to higher order, and also include external tidal shear as a free parameter. Fitting for the shear proves crucial to finding a physical (positive-definite density) model. For B1422+231, working to order kmax= 5 (and including shear) yields a model that is physical but implausible. Going to higher order (kmax>~ 9) reduces global departures from ellipticity, but at the cost of introducing small-scale wiggles in proximity to the bright images. These localized undulations are more pronounced in B2045+265, where kmax~ 17 multipoles are required to smooth out large-scale deviations from elliptical symmetry. Such modes surely cannot be taken at face value; they must indicate that the models are trying to reproduce some other sort of structure. Our formalism naturally finds models that fit the data exactly, but we use B0712+472 to show that measurement uncertainties have little effect on our results. Finally, we consider the system B1933+503, where two sources are lensed by the same foreground galaxy. The additional constraints provided by the images of the second source render the multipole model unphysical. We conclude that external shear must be taken into account to obtain plausible models, and that a purely smooth angular structure for the lens galaxy does not provide a viable alternative to the prevailing CDM clump hypothesis.

In-Use Emissions and Estimated Impacts of Traditional, Natural- and Forced-Draft Cookstoves in Rural Malawi

PubMed Central

2017-01-01

Emissions from traditional cooking practices in low- and middle-income countries have detrimental health and climate effects; cleaner-burning cookstoves may provide “co-benefits”. Here we assess this potential via in-home measurements of fuel-use and emissions and real-time optical properties of pollutants from traditional and alternative cookstoves in rural Malawi. Alternative cookstove models were distributed by existing initiatives and include a low-cost ceramic model, two forced-draft cookstoves (FDCS; Philips HD4012LS and ACE-1), and three institutional cookstoves. Among household cookstoves, emission factors (EF; g (kg wood)−1) were lowest for the Philips, with statistically significant reductions relative to baseline of 45% and 47% for fine particulate matter (PM2.5) and carbon monoxide (CO), respectively. The Philips was the only cookstove tested that showed significant reductions in elemental carbon (EC) emission rate. Estimated health and climate cobenefits of alternative cookstoves were smaller than predicted from laboratory tests due to the effects of real-world conditions including fuel variability and nonideal operation. For example, estimated daily PM intake and field-measurement-based global warming commitment (GWC) for the Philips FDCS were a factor of 8.6 and 2.8 times higher, respectively, than those based on lab measurements. In-field measurements provide an assessment of alternative cookstoves under real-world conditions and as such likely provide more realistic estimates of their potential health and climate benefits than laboratory tests. PMID:28060518

Alternative fuels and vehicles choice model

DOT National Transportation Integrated Search

1994-10-01

This report describes the theory and implementation of a model of alternative fuel and vehicle choice (AFVC), designed for use with the United States Department of Energy's Alternative Fuels Trade Model (AFTM). The AFTM is a static equilibrium model ...

An analysis of alternative funding for physicians practicing gynecologic oncology in Ontario, Canada prior to 2001.

PubMed

Elit, L

2006-01-01

To consider the policy issue of physician reimbursement by examining the events that preceded the Ontario Gynecologic Oncologists moving from a fee-for-service environment to an alternate payment plan in 2001. The sources of information included a literature search, reviewing Canadian newspapers, interactions with key leaders in the field (Ontario Medication Association, University physicians), and meeting minutes from both university and provincial groups considering alternate payment plans. The problem for Ontario Gynecologic Oncologists involved the goal of providing excellent clinical care, undergraduate and postgraduate education, research and administration in the midst of problems with recruitment, retention and remuneration. Multiple causes for this problem included limitations in health care spending and a fee for service payment schedule that did not adequately reimburse complex care. This funding problem got on the agenda as a result of a front page article in the national newspaper and letters of concern solicited from local members of the provincial parliament. The policy formulation needed to account for alternate financial options and the roles of institutional structures such as the universities, Cancer Care Ontario and the Ontario University Health Science Centers. The influences on the evolution of the new funding policy included the actors, their interests, their values, research on the topic and institutions. The tensions between the goal of excellence in care, education, research and administration and difficulties with recruitment, retention and reimbursement, led the Ontario Gynecologic Oncologists to seek an alternate mechanism of reimbursement from the fee-for-service model.

In Silico Analysis of the Regulation of the Photosynthetic Electron Transport Chain in C3 Plants.

PubMed

Morales, Alejandro; Yin, Xinyou; Harbinson, Jeremy; Driever, Steven M; Molenaar, Jaap; Kramer, David M; Struik, Paul C

2018-02-01

We present a new simulation model of the reactions in the photosynthetic electron transport chain of C3 species. We show that including recent insights about the regulation of the thylakoid proton motive force, ATP/NADPH balancing mechanisms (cyclic and noncyclic alternative electron transport), and regulation of Rubisco activity leads to emergent behaviors that may affect the operation and regulation of photosynthesis under different dynamic environmental conditions. The model was parameterized with experimental results in the literature, with a focus on Arabidopsis ( Arabidopsis thaliana ). A dataset was constructed from multiple sources, including measurements of steady-state and dynamic gas exchange, chlorophyll fluorescence, and absorbance spectroscopy under different light intensities and CO 2 , to test predictions of the model under different experimental conditions. Simulations suggested that there are strong interactions between cyclic and noncyclic alternative electron transport and that an excess capacity for alternative electron transport is required to ensure adequate redox state and lumen pH. Furthermore, the model predicted that, under specific conditions, reduction of ferredoxin by plastoquinol is possible after a rapid increase in light intensity. Further analysis also revealed that the relationship between ATP synthesis and proton motive force was highly regulated by the concentrations of ATP, ADP, and inorganic phosphate, and this facilitated an increase in nonphotochemical quenching and proton motive force under conditions where metabolism was limiting, such as low CO 2 , high light intensity, or combined high CO 2 and high light intensity. The model may be used as an in silico platform for future research on the regulation of photosynthetic electron transport. © 2018 American Society of Plant Biologists. All Rights Reserved.

Relation between social information processing and intimate partner violence in dating couples.

PubMed

Setchell, Sarah; Fritz, Patti Timmons; Glasgow, Jillian

2017-07-01

We used couple-level data to predict physical acts of intimate partner violence (IPV) from self-reported negative emotions and social information-processing (SIP) abilities among 100 dating couples (n = 200; mean age = 21.45 years). Participants read a series of hypothetical conflict situation vignettes and responded to questionnaires to assess negative emotions and various facets of SIP including attributions for partner behavior, generation of response alternatives, and response selection. We conducted a series of negative binomial mixed-model regressions based on the actor-partner interdependence model (APIM; Kenny, Kashy, & Cook, 2006, Dyadic data analysis. New York, NY: Guilford Press). There were significant results for the response generation and negative emotion models. Participants who generated fewer coping response alternatives were at greater risk of victimization (actor effect). Women were at greater risk of victimization if they had partners who generated fewer coping response alternatives (sex by partner interaction effect). Generation of less competent coping response alternatives predicted greater risk of perpetration among men, whereas generation of more competent coping response alternatives predicted greater risk of victimization among women (sex by actor interaction effects). Two significant actor by partner interaction effects were found for the negative emotion models. Participants who reported discrepant levels of negative emotions from their partners were at greatest risk of perpetration. Participants who reported high levels of negative emotions were at greatest risk of victimization if they had partners who reported low levels of negative emotions. This research has implications for researchers and clinicians interested in addressing the problem of IPV. Aggr. Behav. 43:329-341, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Simulation of constituent transport in the Red River of the North basin, North Dakota and Minnesota, during unsteady-flow conditions, 1977 and 2003-04

USGS Publications Warehouse

Nustad, Rochelle A.; Bales, Jerad D.

2006-01-01

The Bureau of Reclamation identified eight water-supply alternatives for the Red River Valley Water Supply Project. Of those alternatives, six were considered for this study. Those six alternatives include a no-action alternative, two in-basin alternatives, and three interbasin alternatives. To address concerns of stakeholders and to provide information for an environmental impact statement, the U.S. Geological Survey, in cooperation with the Bureau of Reclamation, developed and applied a water-quality model to simulate the transport of total dissolved solids, sulfate, chloride, sodium, and total phosphorus during unsteady-flow conditions and to simulate the effects of the water-supply alternatives on water quality in the Red River and the Sheyenne River. The physical domain of the model, hereinafter referred to as the Red River model, includes the Red River from Wahpeton, North Dakota, to Emerson, Manitoba, and the Sheyenne River from below Baldhill Dam, North Dakota, to the confluence with the Red River. Boundary conditions were specified for May 15 through October 31, 2003, and January 15 through June 30, 2004. Measured streamflow data were available for August 1 through October 31, 2003, and April 1 through June 30, 2004, but water-quality data were available only for September 15 through 16, 2003, and May 10 through 13, 2004. The water-quality boundary conditions were assumed to be time invariant for the entire calibration period and to be equal to the measured value. The average difference between the measured and simulated streamflows was less than 4 percent for both calibration periods, and most differences were less than 2 percent. The average differences are considered to be acceptable because the differences are less than 5 percent, or the same as the error that would be expected in a typical streamflow measurement. Simulated total dissolved solids, sulfate, chloride, and sodium concentrations generally were less than measured concentrations for both calibration periods. The average absolute differences generally were less than 25 percent. Total phosphorus was simulated as a nonconservative constituent by assuming that concentrations change according to a first-order decay rate. The average difference between the measured and simulated total phosphorus concentrations was 6.2 percent for the 2003 calibration period and -24 percent for the 2004 calibration period. The Red River model demonstrates sensitivity to changes in boundary conditions so a reasonable assumption is that the model can be used to compare relative effects of the various water-supply alternatives. The calibrated Red River model was used to simulate the effects of the six water-supply alternatives by using measured streamflows for September 1, 1976, through August 31, 1977, when streamflows throughout the Red River Basin were relatively low. Streamflows for the Red River at Fargo, North Dakota, were less than 17.9 cubic feet per second on 159 days of that 12-month period, and monthly average streamflows for the Red River at Grand Forks, North Dakota, and the Red River at Emerson, Manitoba, were less than 30 percent of the respective long-term average monthly streamflows for 11 of the 12 months during September 1976 through August 1977. Water-quality boundary conditions were generated using a stochastic approach in which probability distributions derived from all available historical data on instream concentrations were used to produce daily concentrations at model boundaries. Return flow concentrations were estimated from source concentrations and current (2006) wastewater-treatment technology. Because no historical information on ungaged local inflow constituent concentrations is available to estimate those boundary conditions, time-invariant concentrations for the low-flow 2003 calibration period were used as the ungaged local inflow boundary conditions. The effects of the water-supply alternatives on water quality in the Red River and

A critique of the cross-lagged panel model.

PubMed

Hamaker, Ellen L; Kuiper, Rebecca M; Grasman, Raoul P P P

2015-03-01

The cross-lagged panel model (CLPM) is believed by many to overcome the problems associated with the use of cross-lagged correlations as a way to study causal influences in longitudinal panel data. The current article, however, shows that if stability of constructs is to some extent of a trait-like, time-invariant nature, the autoregressive relationships of the CLPM fail to adequately account for this. As a result, the lagged parameters that are obtained with the CLPM do not represent the actual within-person relationships over time, and this may lead to erroneous conclusions regarding the presence, predominance, and sign of causal influences. In this article we present an alternative model that separates the within-person process from stable between-person differences through the inclusion of random intercepts, and we discuss how this model is related to existing structural equation models that include cross-lagged relationships. We derive the analytical relationship between the cross-lagged parameters from the CLPM and the alternative model, and use simulations to demonstrate the spurious results that may arise when using the CLPM to analyze data that include stable, trait-like individual differences. We also present a modeling strategy to avoid this pitfall and illustrate this using an empirical data set. The implications for both existing and future cross-lagged panel research are discussed. (c) 2015 APA, all rights reserved).

rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data.

PubMed

Shen, Shihao; Park, Juw Won; Lu, Zhi-xiang; Lin, Lan; Henry, Michael D; Wu, Ying Nian; Zhou, Qing; Xing, Yi

2014-12-23

Ultra-deep RNA sequencing (RNA-Seq) has become a powerful approach for genome-wide analysis of pre-mRNA alternative splicing. We previously developed multivariate analysis of transcript splicing (MATS), a statistical method for detecting differential alternative splicing between two RNA-Seq samples. Here we describe a new statistical model and computer program, replicate MATS (rMATS), designed for detection of differential alternative splicing from replicate RNA-Seq data. rMATS uses a hierarchical model to simultaneously account for sampling uncertainty in individual replicates and variability among replicates. In addition to the analysis of unpaired replicates, rMATS also includes a model specifically designed for paired replicates between sample groups. The hypothesis-testing framework of rMATS is flexible and can assess the statistical significance over any user-defined magnitude of splicing change. The performance of rMATS is evaluated by the analysis of simulated and real RNA-Seq data. rMATS outperformed two existing methods for replicate RNA-Seq data in all simulation settings, and RT-PCR yielded a high validation rate (94%) in an RNA-Seq dataset of prostate cancer cell lines. Our data also provide guiding principles for designing RNA-Seq studies of alternative splicing. We demonstrate that it is essential to incorporate biological replicates in the study design. Of note, pooling RNAs or merging RNA-Seq data from multiple replicates is not an effective approach to account for variability, and the result is particularly sensitive to outliers. The rMATS source code is freely available at rnaseq-mats.sourceforge.net/. As the popularity of RNA-Seq continues to grow, we expect rMATS will be useful for studies of alternative splicing in diverse RNA-Seq projects.

Collagen reconstitution is inversely correlated with induction of limb regeneration in Ambystoma mexicanum.

PubMed

Satoh, Akira; Hirata, Ayako; Makanae, Aki

2012-03-01

Amphibians can regenerate missing body parts, including limbs. The regulation of collagen has been considered to be important in limb regeneration. Collagen deposition is suppressed during limb regeneration, so we investigated collagen deposition and apical epithelial cap (AEC) formation during axolotl limb regeneration. The accessory limb model (ALM) has been developed as an alternative model for studying limb regeneration. Using this model, we investigated the relationship between nerves, epidermis, and collagen deposition. We found that Sp-9, an AEC marker gene, was upregulated by direct interaction between nerves and epidermis. However, collagen deposition hindered this interaction, and resulted in the failure of limb regeneration. During wound healing, an increase in deposition of collagen caused a decrease in the blastema induction rate in ALM. Wound healing and limb regeneration are alternate processes.

Traditional Payment Models in Radiology: Historical Context for Ongoing Reform.

PubMed

Silva, Ezequiel; McGinty, Geraldine B; Hughes, Danny R; Duszak, Richard

2016-10-01

The passage of the Medicare Access and CHIP Reauthorization Act (MACRA) replaces the sustainable growth rate with a payment system based on quality and alternative payment model participation. The general structure of payment under MACRA is included in the statute, but the rules and regulations defining its implementation are yet to be formalized. It is imperative that the radiology profession inform policymakers on their role in health care under MACRA. This will require a detailed understanding of prior legislative and nonlegislative actions that helped shape MACRA. To that end, the authors provide a detailed historical context for payment reform, focusing on the payment quality initiatives and alternative payment model demonstrations that helped provide the foundation of future MACRA-driven payment reform. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Probing gravity at cosmological scales by measurements which test the relationship between gravitational lensing and matter overdensity.

PubMed

Zhang, Pengjie; Liguori, Michele; Bean, Rachel; Dodelson, Scott

2007-10-05

The standard cosmology is based on general relativity (GR) and includes dark matter and dark energy and predicts a fixed relationship between the gravitational potentials responsible for gravitational lensing and the matter overdensity. Alternative theories of gravity often make different predictions. We propose a set of measurements which can test this relationship, thereby distinguishing between dark energy or matter models and models in which gravity differs from GR. Planned surveys will be able to measure E(G), an observational quantity whose expectation value is equal to the ratio of the Laplacian of the Newtonian potentials to the peculiar velocity divergence, to percent accuracy. This will easily separate alternatives such as the cold dark matter model with a cosmological constant, Dvali-Gabadadze-Porrati, TeVeS, and f(R) gravity.

Development and construct validity of the Classroom Strategies Scale-Observer Form.

PubMed

Reddy, Linda A; Fabiano, Gregory; Dudek, Christopher M; Hsu, Louis

2013-12-01

Research on progress monitoring has almost exclusively focused on student behavior and not on teacher practices. This article presents the development and validation of a new teacher observational assessment (Classroom Strategies Scale) of classroom instructional and behavioral management practices. The theoretical underpinnings and empirical basis for the instructional and behavioral management scales are presented. The Classroom Strategies Scale (CSS) evidenced overall good reliability estimates including internal consistency, interrater reliability, test-retest reliability, and freedom from item bias on important teacher demographics (age, educational degree, years of teaching experience). Confirmatory factor analyses (CFAs) of CSS data from 317 classrooms were carried out to assess the level of empirical support for (a) a 4 first-order factor theory concerning teachers' instructional practices, and (b) a 4 first-order factor theory concerning teachers' behavior management practice. Several fit indices indicated acceptable fit of the (a) and (b) CFA models to the data, as well as acceptable fit of less parsimonious alternative CFA models that included 1 or 2 second-order factors. Information-theory-based indices generally suggested that the (a) and (b) CFA models fit better than some more parsimonious alternative CFA models that included constraints on relations of first-order factors. Overall, CFA first-order and higher order factor results support the CSS-Observer Total, Composite, and subscales. Suggestions for future measurement development efforts are outlined. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Performance analysis of a diesel engine driven brushless alternator with combined AC and thyristor fed DC loads through PSPICE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayanan, S.S.Y.; Ananthakrishnan, P.; Hangari, V.U.

1995-12-31

A brushless alternator with damper windings in the main alternator and with combined ac and thyristor fed dc loads has been handled ab initio as a total modeling and simulation problem for which a complete steady state performance prediction algorithm has been developed through proper application of Park`s equivalent circuit approach individually to the main and exciter alternator units of the brushless alternator. Details of the problems faced during implementation of this algorithm through PSPICE for the case of a specific 125 kVA brushless alternator as well as methods adopted for successfully overcoming the same have then been presented. Finallymore » a comparison of the predicted performance with those obtained experimentally for this 125 kVA unit has also been provided for the cases of both thyristor fed dc load alone as well as combined ac and thyristor fed dc loads. To enable proper calculation of derating factors to be used in the design of such brushless alternators, the simulation results then include harmonic analysis of the alternator output voltage and current waveforms at the point of common connection of the ac and thyristor fed dc load, damper winding currents, main alternator field winding current, exciter alternator armature voltage and the alternator developed torque and torque angle pulsations.« less

Evaluation of Alternative Atomistic Models for the Incipient Growth of ZnO by Atomic Layer Deposition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu, Manh-Hung; Tian, Liang; Chaker, Ahmad

ZnO thin films are interesting for applications in several technological fields, including optoelectronics and renewable energies. Nanodevice applications require controlled synthesis of ZnO structures at nanometer scale, which can be achieved via atomic layer deposition (ALD). However, the mechanisms governing the initial stages of ALD had not been addressed until very recently. Investigations into the initial nucleation and growth as well as the atomic structure of the heterointerface are crucial to optimize the ALD process and understand the structure-property relationships for ZnO. We have used a complementary suite of in situ synchrotron x-ray techniques to investigate both the structural andmore » chemical evolution during ZnO growth by ALD on two different substrates, i.e., SiO2 and Al2O3, which led us to formulate an atomistic model of the incipient growth of ZnO. The model relies on the formation of nanoscale islands of different size and aspect ratio and consequent disorder induced in the Zn neighbors' distribution. However, endorsement of our model requires testing and discussion of possible alternative models which could account for the experimental results. In this work, we review, test, and rule out several alternative models; the results confirm our view of the atomistic mechanisms at play, which influence the overall microstructure and resulting properties of the final thin film.« less

Caring for Us, Caring about People.

ERIC Educational Resources Information Center

Morris, Robert

1992-01-01

Proposes an alternative conceptual framework for social work practice. Describes the present model as lacking a clear, easily articulated identity. Details social problems, including family structure changes, mental illness, physical disability, delinquency, and poverty. Provides key steps to alleviating these problems, emphasizing more active…

Apollo 7 - Press Kit

NASA Technical Reports Server (NTRS)

1968-01-01

Contents include the following: General release. Mission objectives. Mission description. Flight plan. Alternate missions. Experiments. Abort model. Spacecraft structure system. The Saturn 1B launch vehicle. Flight sequence. Launch preparations. Mission control center-Houston. Manned space flight network. Photographic equipment. Apollo 7 crew. Apollo 7 test program.

Modeling Temporal and Spatial Flows of Ecosystem Services in Chittenden County, VT

NASA Astrophysics Data System (ADS)

Voigt, B. G.; Bagstad, K.; Johnson, G.; Villa, F.

2010-12-01

This paper documents the integration of ARIES (ARtificial Intelligence for Ecosystem Services) with the land use change model UrbanSim to explore the impacts of current and future land use patterns on flood protection and water provision services in Chittenden County, VT. ARIES, an open source modeling platform, is particularly well-suited for measuring, mapping, and modeling the temporal and spatial flows of ecosystem services across the landscape, linking the areas of provision (sources) with human beneficiaries (users) through a spatially explicit agent-based modeling approach. UrbanSim is an open source agent-based land use model designed to facilitate a wide-range of scenarios based on user-specified behavioral assumptions, zoning regulations, and demographic, economic, and infrastructure (e.g. transportation, water, sewer, etc.) parameters. Ecosystem services travel through time and space and are susceptible to disruption and destruction from both natural and anthropogenic perturbations. The conversion of forested or agricultural land to urbanizing uses is replete with a long history of hydrologic impairment, habitat fragmentation, and the degradation of sensitive landscapes. Development decisions are predicated on the presence of landscape characteristics that meet the needs of developers and satisfy the desires of consumers, with minimal consideration of access to or effect on the provision of ecosystem services. The County houses nearly 25% of the state’s population and several employment centers that draw labor from throughout the region. Additionally, the County is expected to maintain modest residential and employment growth over the next 30 years, and will continue to serve as the state’s population and employment center. Expected future growth is likely to adversely affect the remaining farm and forest land in the County in the absence of policies to support sustainable development. We demonstrate how ARIES can be used to quantify changes in ecosystem service provision based on the outcomes of alternative land use change model scenarios. Stakeholder workshops were hosted to develop scenarios relevant to planning for future growth in the County, including alternative zoning regulations, road network improvements, and a range of future population projections. The results of the land use change simulations were passed to ARIES to model flood protection and water provision services for each of the alternative scenarios. We present Bayesian models of the ecosystem services as individual source, sink, and use components coupled with models of temporal and spatial flows of services across the landscape. Specific beneficiaries include homeowners, farmers, and other business property owners. The location choice decisions of residential and non-residential agents under the alternative scenarios resulted in varying access to ecosystem services depending on development density, habitat fragmentation, and the degree of hydrological impairment, among other factors. Modeled outputs include maps depicting flow paths (linking sources to beneficiaries), changes in land use, hotspot locations that are critical to sustain the flow of services across the landscape, and the demand for and supply of the modeled services.

Alternative spatial configurations to reflect landscape structure in a hydrological model: SUMMA applications to the Reynolds Creek Watershed and the Columbia River Basin

NASA Astrophysics Data System (ADS)

Nijssen, Bart; Clark, Martyn; Mizukami, Naoki; Chegwidden, Oriana

2016-04-01

Most existing hydrological models use a fixed representation of landscape structure. For example, high-resolution, spatially-distributed models may use grid cells that exchange moisture through the saturated subsurface or may divide the landscape into hydrologic response units that only exchange moisture through surface channels. Alternatively, many regional models represent the landscape through coarse elements that do not model any moisture exchange between these model elements. These spatial organizations are often represented at a low-level in the model code and its data structures, which makes it difficult to evaluate different landscape representations using the same hydrological model. Instead, such experimentation requires the use of multiple, different hydrological models, which in turn complicates the analysis, because differences in model outcomes are no longer constrained by differing spatial representations. This inflexibility in the representation of landscape structure also limits a model's capability for scaling local processes to regional outcomes. In this study, we used the Structure for Unifying Multiple Modeling Alternatives (SUMMA) to evaluate different model spatial configurations to represent landscape structure and to evaluate scaling behavior. SUMMA can represent the moisture exchange between arbitrarily shaped landscape elements in a number of different ways, while using the same model parameterizations for vertical fluxes. This allows us to isolate the effects of changes in landscape representations on modeled hydrological fluxes and states. We examine the effects of spatial configuration in Reynolds Creek, Idaho, USA, which is a research watershed with gaged areas from 1-20 km2. We then use the same modeling system to evaluate scaling behavior in simulated hydrological fluxes in the Columbia River Basin, Pacific Northwest, USA. This basin drains more than 500,000 km2 and includes the Reynolds Creek Watershed.

Nothobranchius as a model for aging studies. A review

PubMed Central

Lucas-Sánchez, Alejandro; Almaida-Pagán, Pedro Francisco; Mendiola, Pilar; de Costa, Jorge

2014-01-01

In recent decades, the increase in human longevity has made it increasingly important to expand our knowledge on aging. To accomplish this, the use of animal models is essential, with the most common being mouse (phylogenetically similar to humans, and a model with a long life expectancy) and Caenorhabditis elegans (an invertebrate with a short life span, but quite removed from us in evolutionary terms). However, some sort of model is needed to bridge the differences between those mentioned above, achieving a balance between phylogenetic distance and life span. Fish of the genus Nothobranchius were suggested 10 years ago as a possible alternative for the study of the aging process. In the meantime, numerous studies have been conducted at different levels: behavioral (including the study of the rest-activity rhythm), populational, histochemical, biochemical and genetic, among others, with very positive results. This review compiles what we know about Nothobranchius to date, and examines its future prospects as a true alternative to the classic models for studies on aging. PMID:25110612

A Python Calculator for Supernova Remnant Evolution

NASA Astrophysics Data System (ADS)

Leahy, D. A.; Williams, J. E.

2017-05-01

A freely available Python code for modeling supernova remnant (SNR) evolution has been created. This software is intended for two purposes: to understand SNR evolution and to use in modeling observations of SNR for obtaining good estimates of SNR properties. It includes all phases for the standard path of evolution for spherically symmetric SNRs. In addition, alternate evolutionary models are available, including evolution in a cloudy ISM, the fractional energy-loss model, and evolution in a hot low-density ISM. The graphical interface takes in various parameters and produces outputs such as shock radius and velocity versus time, as well as SNR surface brightness profile and spectrum. Some interesting properties of SNR evolution are demonstrated using the program.

Program for fundamental and applied research of fuel cells in VNIIEF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anisin, A.V.; Borisseonock, V.A.; Novitskii, Y.Z.

1996-04-01

According to VNIIEF the integral part of development of fuel cell power plants is fundamental and applied research. This paper describes areas of research on molten carbonate fuel cells. Topics include the development of mathematical models for porous electrodes, thin film electrolytes, the possibility of solid nickel anodes, model of activation polarization of anode, electrolyte with high solubility of oxygen. Other areas include research on a stationary mode of stack operation, anticorrosion coatings, impedance diagnostic methods, ultrasound diagnostics, radiation treatments, an air aluminium cell, and alternative catalysts for low temperature fuel cells.

Business model for sensor-based fall recognition systems.

PubMed

Fachinger, Uwe; Schöpke, Birte

2014-01-01

AAL systems require, in addition to sophisticated and reliable technology, adequate business models for their launch and sustainable establishment. This paper presents the basic features of alternative business models for a sensor-based fall recognition system which was developed within the context of the "Lower Saxony Research Network Design of Environments for Ageing" (GAL). The models were developed parallel to the R&D process with successive adaptation and concretization. An overview of the basic features (i.e. nine partial models) of the business model is given and the mutual exclusive alternatives for each partial model are presented. The partial models are interconnected and the combinations of compatible alternatives lead to consistent alternative business models. However, in the current state, only initial concepts of alternative business models can be deduced. The next step will be to gather additional information to work out more detailed models.

Explaining variation in tropical plant community composition: influence of environmental and spatial data quality.

PubMed

Jones, Mirkka M; Tuomisto, Hanna; Borcard, Daniel; Legendre, Pierre; Clark, David B; Olivas, Paulo C

2008-03-01

The degree to which variation in plant community composition (beta-diversity) is predictable from environmental variation, relative to other spatial processes, is of considerable current interest. We addressed this question in Costa Rican rain forest pteridophytes (1,045 plots, 127 species). We also tested the effect of data quality on the results, which has largely been overlooked in earlier studies. To do so, we compared two alternative spatial models [polynomial vs. principal coordinates of neighbour matrices (PCNM)] and ten alternative environmental models (all available environmental variables vs. four subsets, and including their polynomials vs. not). Of the environmental data types, soil chemistry contributed most to explaining pteridophyte community variation, followed in decreasing order of contribution by topography, soil type and forest structure. Environmentally explained variation increased moderately when polynomials of the environmental variables were included. Spatially explained variation increased substantially when the multi-scale PCNM spatial model was used instead of the traditional, broad-scale polynomial spatial model. The best model combination (PCNM spatial model and full environmental model including polynomials) explained 32% of pteridophyte community variation, after correcting for the number of sampling sites and explanatory variables. Overall evidence for environmental control of beta-diversity was strong, and the main floristic gradients detected were correlated with environmental variation at all scales encompassed by the study (c. 100-2,000 m). Depending on model choice, however, total explained variation differed more than fourfold, and the apparent relative importance of space and environment could be reversed. Therefore, we advocate a broader recognition of the impacts that data quality has on analysis results. A general understanding of the relative contributions of spatial and environmental processes to species distributions and beta-diversity requires that methodological artefacts are separated from real ecological differences.

Workgroup Report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies

PubMed Central

Coecke, Sandra; Goldberg, Alan M; Allen, Sandra; Buzanska, Leonora; Calamandrei, Gemma; Crofton, Kevin; Hareng, Lars; Hartung, Thomas; Knaut, Holger; Honegger, Paul; Jacobs, Miriam; Lein, Pamela; Li, Abby; Mundy, William; Owen, David; Schneider, Steffen; Silbergeld, Ellen; Reum, Torsten; Trnovec, Tomas; Monnet-Tschudi, Florianne; Bal-Price, Anna

2007-01-01

This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, on 19–21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Council, and the Johns Hopkins University Center for Alternatives to Animal Testing. The primary aim of the workshop was to identify and catalog potential methods that could be used to assess how data from in vitro alternative methods could help to predict and identify DNT hazards. Working groups focused on two different aspects: a) details on the science available in the field of DNT, including discussions on the models available to capture the critical DNT mechanisms and processes, and b) policy and strategy aspects to assess the integration of alternative methods in a regulatory framework. This report summarizes these discussions and details the recommendations and priorities for future work. PMID:17589601

Mechanisms of Left-Right Coordination in Mammalian Locomotor Pattern Generation Circuits: A Mathematical Modeling View

PubMed Central

Talpalar, Adolfo E.; Rybak, Ilya A.

2015-01-01

The locomotor gait in limbed animals is defined by the left-right leg coordination and locomotor speed. Coordination between left and right neural activities in the spinal cord controlling left and right legs is provided by commissural interneurons (CINs). Several CIN types have been genetically identified, including the excitatory V3 and excitatory and inhibitory V0 types. Recent studies demonstrated that genetic elimination of all V0 CINs caused switching from a normal left-right alternating activity to a left-right synchronized “hopping” pattern. Furthermore, ablation of only the inhibitory V0 CINs (V0D subtype) resulted in a lack of left-right alternation at low locomotor frequencies and retaining this alternation at high frequencies, whereas selective ablation of the excitatory V0 neurons (V0V subtype) maintained the left–right alternation at low frequencies and switched to a hopping pattern at high frequencies. To analyze these findings, we developed a simplified mathematical model of neural circuits consisting of four pacemaker neurons representing left and right, flexor and extensor rhythm-generating centers interacting via commissural pathways representing V3, V0D, and V0V CINs. The locomotor frequency was controlled by a parameter defining the excitation of neurons and commissural pathways mimicking the effects of N-methyl-D-aspartate on locomotor frequency in isolated rodent spinal cord preparations. The model demonstrated a typical left-right alternating pattern under control conditions, switching to a hopping activity at any frequency after removing both V0 connections, a synchronized pattern at low frequencies with alternation at high frequencies after removing only V0D connections, and an alternating pattern at low frequencies with hopping at high frequencies after removing only V0V connections. We used bifurcation theory and fast-slow decomposition methods to analyze network behavior in the above regimes and transitions between them. The model reproduced, and suggested explanation for, a series of experimental phenomena and generated predictions available for experimental testing. PMID:25970489

The "Function-to-Flow" Model: An Interdisciplinary Approach to Assessing Movement within and beyond the Context of Climbing

ERIC Educational Resources Information Center

Lloyd, Rebecca

2015-01-01

Background: Physical Education (PE) programmes are expanding to include alternative activities yet what is missing is a conceptual model that facilitates how the learning process may be understood and assessed beyond the dominant sport-technique paradigm. Purpose: The purpose of this article was to feature the emergence of a Function-to-Flow (F2F)…

Alternatives for jet engine control

NASA Technical Reports Server (NTRS)

Sain, M. K.

1980-01-01

Nonlinear modeling researches involving the use of tensor analysis are presented. Progress was achieved by extending the studies to a controlled equation and by considering more complex situations. Included in the report are calculations illustrating the modeling methodology for cases in which variables take values in real spaces of dimension up to three, and in which the degree of tensor term retention is as high as three.

Examination of the wind speed limit function in the Rothermel surface fire spread model

Treesearch

Patricia L. Andrews; Miguel G. Cruz; Richard C. Rothermel

2013-01-01

The Rothermel surface fire spread model includes a wind speed limit, above which predicted rate of spread is constant. Complete derivation of the wind limit as a function of reaction intensity is given, along with an alternate result based on a changed assumption. Evidence indicates that both the original and the revised wind limits are too restrictive. Wind limit is...

The Idaho dedicated education unit model: cost-effective, high-quality education.

PubMed

Springer, Pamela J; Johnson, Patricia; Lind, Bonnie; Walker, Eldon; Clavelle, Joanne; Jensen, Nancy

2012-01-01

Faculty face many challenges in delivering clinical education, including faculty availability, the complexity of the faculty role, and limited clinical placements. Dedicated education units (DEUs) are being explored as alternatives to traditional clinical placement models. The authors describe the successful development of a DEU that resulted in positive student outcomes at reduced cost to both the school and the medical center.

OAKSIM: An individual-tree growth and yield simulator for managed, even-aged, upland oak stands

Treesearch

Donald E. Hilt; Donald E. Hilt

1985-01-01

OAKSIM is an individual-tree growth and yield simulator for managed, even-aged, upland oak stands. Growth and yield projections for various thinning alternatives can be made with OAKSIM for a period of up to 50 years. Simulator components include an individual-tree diameter growth model, a mortality model, height prediction equations, bark ratio equations, a taper-...

Model dielectric function for 2D semiconductors including substrate screening

NASA Astrophysics Data System (ADS)

Trolle, Mads L.; Pedersen, Thomas G.; Véniard, Valerie

2017-01-01

Dielectric screening of excitons in 2D semiconductors is known to be a highly non-local effect, which in reciprocal space translates to a strong dependence on momentum transfer q. We present an analytical model dielectric function, including the full non-linear q-dependency, which may be used as an alternative to more numerically taxing ab initio screening functions. By verifying the good agreement between excitonic optical properties calculated using our model dielectric function, and those derived from ab initio methods, we demonstrate the versatility of this approach. Our test systems include: Monolayer hBN, monolayer MoS2, and the surface exciton of a 2 × 1 reconstructed Si(111) surface. Additionally, using our model, we easily take substrate screening effects into account. Hence, we include also a systematic study of the effects of substrate media on the excitonic optical properties of MoS2 and hBN.

U.S. Patent Pending, Cyberspace Security System for Complex Systems, U.S. Patent Application No.: 14/134,949

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abercrombie, Robert K; Sheldon, Frederick T; Mili, Ali

A computer implemented method monetizes the security of a cyber-system in terms of losses each stakeholder may expect to lose if a security break down occurs. A non-transitory media stores instructions for generating a stake structure that includes costs that each stakeholder of a system would lose if the system failed to meet security requirements and generating a requirement structure that includes probabilities of failing requirements when computer components fails. The system generates a vulnerability model that includes probabilities of a component failing given threats materializing and generates a perpetrator model that includes probabilities of threats materializing. The system generatesmore » a dot product of the stakes structure, the requirement structure, the vulnerability model and the perpetrator model. The system can further be used to compare, contrast and evaluate alternative courses of actions best suited for the stakeholders and their requirements.« less

Manpower Mix for Health Services

PubMed Central

Shuman, Larry J.; Young, John P.; Naddor, Eliezer

1971-01-01

A model is formulated to determine the mix of manpower and technology needed to provide health services of acceptable quality at a minimum total cost to the community. Total costs include both the direct costs associated with providing the services and with developing additional manpower and the indirect costs (shortage costs) resulting from not providing needed services. The model is applied to a hypothetical neighborhood health center, and its sensitivity to alternative policies is investigated by cost-benefit analyses. Possible extensions of the model to include dynamic elements in health delivery systems are discussed, as is its adaptation for use in hospital planning, with a changed objective function. PMID:5095652

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: a workshop report.

PubMed

van der Laan, Jan Willem; Chapin, Robert E; Haenen, Bert; Jacobs, Abigail C; Piersma, Aldert

2012-06-01

Reproductive toxicity testing is characterized by high animal use. For registration of pharmaceutical compounds, developmental toxicity studies are usually conducted in both rat and rabbits. Efforts have been underway for a long time to design alternatives to animal use. Implementation has lagged, partly because of uncertainties about the applicability domain of the alternatives. The reproductive cycle is complex and not all mechanisms of development can be mimicked in vitro. Therefore, efforts are underway to characterize the available alternative tests with regard to the mechanism of action they include. One alternative test is the mouse embryonic stem cell test (EST), which has been studied since the late 1990s. It is a genuine 3R "alternative" assay as it is essentially animal-free. A meeting was held to review the state-of-the-art of various in vitro models for prediction of developmental toxicity. Although the predictivity of individual assays is improving, a battery of several assays is likely to have even higher predictivity, which is necessary for regulatory acceptance. The workshop concluded that an important first step is a thorough survey of the existing rat and rabbit studies, to fully characterize the frequency of responses and the types of effects seen. At the same time, it is important to continue the optimization of in vitro assays. As more experience accumulates, the optimal conditions, assay structure, and applicability of the alternative assays are expected to emerge. Copyright © 2012 Elsevier Inc. All rights reserved.

Clinical outcomes and cost minimization with an alternative dosing regimen for meropenem in a community hospital.

PubMed

Patel, Gita Wasan; Duquaine, Susan M; McKinnon, Peggy S

2007-12-01

To compare outcomes and cost for the traditional United States Food and Drug Administration-approved dosing regimen for meropenem versus an alternative dosing regimen providing similar pharmacodynamic exposure with a lower total daily dose. Retrospective cohort study with a cost-minimization analysis. A 417-bed, privately owned community hospital. One hundred patients who received meropenem 1 g every 8 or 12 hours (traditional dosing regimen) between January 1 and September 30, 2004 (historical controls), and 192 patients who received meropenem 500 mg every 6 or 8 hours (alternative dosing regimen) between October 1, 2004, and September 30, 2005. Demographic and clinical data were collected for all patients. Cost-minimization analysis was performed by using the drug acquisition cost for meropenem. Demographics, sources of infection, distributions of organisms, and Charlson Comorbidity Index scores were similar between patients in the traditionally and alternatively dosed groups. Concomitant therapy, duration of therapy, success rates, lengths of stay, and in-hospital mortality rates were also similar between groups. Median time to the resolution of symptoms was 3 days for traditional dosing and 1.5 days for alternative dosing (p<0.0001). A logistic regression model including the dosing strategy showed that only polymicrobial infections and sepsis were associated with increased failure rates. The median cost for antibiotics was $439.05/patient for traditional dosing and $234.08/patient for alternative dosing (p<0.0001). An alternative dosing regimen for meropenem with a lower total daily dose yielded patient outcomes, including success rates and duration of therapy, equivalent to those of the traditional dosing regimen. Alternative dosing decreased total drug exposure, costs for antibiotics, and time to the resolution of infections.

Reinventing School Libraries: Alternatives, Models and Options for the Future.

ERIC Educational Resources Information Center

Haycock, Ken

1998-01-01

In collaboration with teachers, teacher librarians have a positive impact on student achievement in content areas, information literacy, and reading motivation and ability. Current professional issues of teacher librarians include role clarification, appropriate preservice education, standards for student information literacy, articulation of…

10 CFR 490.704 - Procedures and documentation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Procedures and documentation. 490.704 Section 490.704 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel... include written documentation stating the quantity of biodiesel purchased, for the given model year, for...

10 CFR 490.704 - Procedures and documentation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Procedures and documentation. 490.704 Section 490.704 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel... include written documentation stating the quantity of biodiesel purchased, for the given model year, for...

10 CFR 490.704 - Procedures and documentation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Procedures and documentation. 490.704 Section 490.704 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel... include written documentation stating the quantity of biodiesel purchased, for the given model year, for...

10 CFR 490.704 - Procedures and documentation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Procedures and documentation. 490.704 Section 490.704 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel... include written documentation stating the quantity of biodiesel purchased, for the given model year, for...

10 CFR 490.704 - Procedures and documentation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Procedures and documentation. 490.704 Section 490.704 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel... include written documentation stating the quantity of biodiesel purchased, for the given model year, for...

Got the "Kids Who Blurt Out" Blues?

ERIC Educational Resources Information Center

Charney, Ruth Sidney

1998-01-01

Strategies for curbing disruptions in the classroom include setting expectations, naming and defining behaviors students must learn, modeling appropriate and alternative behavior, setting up routines showing that self-control is important, settling on predictable consequences for blurting out, having children start over if communication breaks…

Simulation Exercises for an Undergraduate Digital Process Control Course.

ERIC Educational Resources Information Center

Reeves, Deborah E.; Schork, F. Joseph

1988-01-01

Presents six problems from an alternative approach to homework traditionally given to follow-up lectures. Stresses the advantage of longer term exercises which allow for creativity and independence on the part of the student. Problems include: "System Model,""Open-Loop Simulation,""PID Control,""Dahlin…

Some Thoughts on Treasure-Keeping.

ERIC Educational Resources Information Center

O'Brien, Thomas C.

1989-01-01

Instead of studying children's knowing, American educators have applied policies and procedures from factories and assembly lines of the early 1900s. Three factory-oriented themes are paramount: mass production, cost effectiveness, and efficiency. This article suggests a Piagetian alternative to the present mechanistic model. Includes seven…

Standards for Community College Library Facilities.

ERIC Educational Resources Information Center

California State Postsecondary Education Commission, Sacramento.

This report contains proposed standards for community college library facilities developed by the California Postsecondary Education Commission. Formulae for calculating stack space, staff space, reader station space, and total space are included in the report. Three alternative models for revising the present library standards were considered:…

Teaching Biology to Visually Handicapped Students. Resource Manual.

ERIC Educational Resources Information Center

Ricker, Kenneth S.

This resource manual presents numerous techniques for adapting science activities to the visually handicapped student, applicable to introductory biology courses in which microscopes are used extensively in the laboratory. Chapters include information on the following: alternative microscopic viewing techniques, physical models, tactile diagrams,…

A generalized disjunctive programming framework for the optimal synthesis and analysis of processes for ethanol production from corn stover.

PubMed

Scott, Felipe; Aroca, Germán; Caballero, José Antonio; Conejeros, Raúl

2017-07-01

The aim of this study is to analyze the techno-economic performance of process configurations for ethanol production involving solid-liquid separators and reactors in the saccharification and fermentation stage, a family of process configurations where few alternatives have been proposed. Since including these process alternatives creates a large number of possible process configurations, a framework for process synthesis and optimization is proposed. This approach is supported on kinetic models fed with experimental data and a plant-wide techno-economic model. Among 150 process configurations, 40 show an improved MESP compared to a well-documented base case (BC), almost all include solid separators and some show energy retrieved in products 32% higher compared to the BC. Moreover, 16 of them also show a lower capital investment per unit of ethanol produced per year. Several of the process configurations found in this work have not been reported in the literature. Copyright © 2017 Elsevier Ltd. All rights reserved.

Cryogenic Model Materials

NASA Technical Reports Server (NTRS)

Kimmel, W. M.; Kuhn, N. S.; Berry, R. F.; Newman, J. A.

2001-01-01

An overview and status of current activities seeking alternatives to 200 grade 18Ni Steel CVM alloy for cryogenic wind tunnel models is presented. Specific improvements in material selection have been researched including availability, strength, fracture toughness and potential for use in transonic wind tunnel testing. Potential benefits from utilizing damage tolerant life-prediction methods, recently developed fatigue crack growth codes and upgraded NDE methods are also investigated. Two candidate alloys are identified and accepted for cryogenic/transonic wind tunnel models and hardware.

Fatigue-life distributions for reaction time data.

PubMed

Tejo, Mauricio; Niklitschek-Soto, Sebastián; Marmolejo-Ramos, Fernando

2018-06-01

The family of fatigue-life distributions is introduced as an alternative model of reaction time data. This family includes the shifted Wald distribution and a shifted version of the Birnbaum-Saunders distribution. Although the former has been proposed as a way to model reaction time data, the latter has not. Hence, we provide theoretical, mathematical and practical arguments in support of the shifted Birnbaum-Saunders as a suitable model of simple reaction times and associated cognitive mechanisms.

Including gauge-group parameters into the theory of interactions: an alternative mass-generating mechanism for gauge fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aldaya, V.; Lopez-Ruiz, F. F.; Sanchez-Sastre, E.

2006-11-03

We reformulate the gauge theory of interactions by introducing the gauge group parameters into the model. The dynamics of the new 'Goldstone-like' bosons is accomplished through a non-linear {sigma}-model Lagrangian. They are minimally coupled according to a proper prescription which provides mass terms to the intermediate vector bosons without spoiling gauge invariance. The present formalism is explicitly applied to the Standard Model of electroweak interactions.

Turbulence simulation mechanization for Space Shuttle Orbiter dynamics and control studies

NASA Technical Reports Server (NTRS)

Tatom, F. B.; King, R. L.

1977-01-01

The current version of the NASA turbulent simulation model in the form of a digital computer program, TBMOD, is described. The logic of the program is discussed and all inputs and outputs are defined. An alternate method of shear simulation suitable for incorporation into the model is presented. The simulation is based on a von Karman spectrum and the assumption of isotropy. The resulting spectral density functions for the shear model are included.

Confirmatory factor analysis of the Eating Disorder Examination-Questionnaire: A comparison of five factor solutions across vegan and omnivore participants.

PubMed

Heiss, Sydney; Boswell, James F; Hormes, Julia M

2018-05-01

The Eating Disorder Examination-Questionnaire (EDE-Q) is a valid and reliable measure of eating-related pathology, but its factor structure has proven difficult to replicate. Given differences in dietary patterns in vegans compared to omnivores, proper measurement of eating disorder symptoms is especially important in studies of animal product avoiders. This study compared goodness-of-fit of five alternative models of the EDE-Q in vegans (i.e., individuals refraining from all animal products, n = 318) and omnivores (i.e., individuals not restricting intake of animal products, n = 200). Confirmatory factor analyses were used to compare fit indices of the original four-factor model of the EDE-Q, along with alternative three-, two-, full one-, and brief one-factor models. No model provided adequate fit of the data in either sample of respondents. The fit of the brief one-factor model was the closest to acceptable in omnivores, but did not perform as well in vegans. Indicators of fit were comparable in vegans and omnivores across all other models. Our data confirm difficulties in replicating the proposed factor structure of the EDE-Q, including in vegans. More research is needed to determine the suitability of the EDE-Q for quantifying eating behaviors, including in those abstaining from animal products. © 2018 Wiley Periodicals, Inc.

Adaptive Value Normalization in the Prefrontal Cortex Is Reduced by Memory Load

PubMed Central

Burke, C. J.; Seifritz, E.; Tobler, P. N.

2017-01-01

Abstract Adaptation facilitates neural representation of a wide range of diverse inputs, including reward values. Adaptive value coding typically relies on contextual information either obtained from the environment or retrieved from and maintained in memory. However, it is unknown whether having to retrieve and maintain context information modulates the brain’s capacity for value adaptation. To address this issue, we measured hemodynamic responses of the prefrontal cortex (PFC) in two studies on risky decision-making. In each trial, healthy human subjects chose between a risky and a safe alternative; half of the participants had to remember the risky alternatives, whereas for the other half they were presented visually. The value of safe alternatives varied across trials. PFC responses adapted to contextual risk information, with steeper coding of safe alternative value in lower-risk contexts. Importantly, this adaptation depended on working memory load, such that response functions relating PFC activity to safe values were steeper with presented versus remembered risk. An independent second study replicated the findings of the first study and showed that similar slope reductions also arose when memory maintenance demands were increased with a secondary working memory task. Formal model comparison showed that a divisive normalization model fitted effects of both risk context and working memory demands on PFC activity better than alternative models of value adaptation, and revealed that reduced suppression of background activity was the critical parameter impairing normalization with increased memory maintenance demand. Our findings suggest that mnemonic processes can constrain normalization of neural value representations. PMID:28462394

Influence of energy alternatives and carbon emissions on an institution's green reputation.

PubMed

Komarek, Timothy M; Lupi, Frank; Kaplowitz, Michael D; Thorp, Laurie

2013-10-15

Institutions' reputation for being environmentally friendly or 'green' can come from many sources. This paper examines how the attributes of alternative energy management plans impact an institutions' 'green' reputation by focusing on the interaction between 'external' and 'internal' influences. Some 'external' influences on environmental reputation we studied include the institution's mix of fuels, energy conservation effort, carbon emissions targets, investment time-frame, and program cost. The 'internal' influences on institutions' green reputation we examined include altruism (respondents' concern for the welfare of others) and environmentalism (respondents' concern for the environment). Using a stated-preference conjoint survey, we empirically examine how attributes of alternative energy management plans influence a large, research university's 'green' reputation. Our results show that constituents benefit from their institution's green reputation and that the energy management choices of the institution can significantly influence its perceived green reputation. Furthermore, integrating internal and external influences on reputation can create more informative models and better decision-making. Copyright © 2013 Elsevier Ltd. All rights reserved.

Clean Cities Guide to Alternative Fuel and Advanced Medium- and Heavy-Duty Vehicles (Book)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2013-08-01

Today's fleets are increasingly interested in medium-duty and heavy-duty vehicles that use alternative fuels or advanced technologies that can help reduce operating costs, meet emissions requirements, improve fleet sustainability, and support U.S. energy independence. Vehicle and engine manufacturers are responding to this interest with a wide range of options across a steadily growing number of vehicle applications. This guide provides an overview of alternative fuel power systems?including engines, microturbines, electric motors, and fuel cells?and hybrid propulsion systems. The guide also offers a list of individual medium- and heavy-duty vehicle models listed by application, along with associated manufacturer contact information, fuelmore » type(s), power source(s), and related information.« less

Clean Cities Guide to Alternative Fuel and Advanced Medium- and Heavy-Duty Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2013-08-01

Today's fleets are increasingly interested in medium-duty and heavy-duty vehicles that use alternative fuels or advanced technologies that can help reduce operating costs, meet emissions requirements, improve fleet sustainability, and support U.S. energy independence. Vehicle and engine manufacturers are responding to this interest with a wide range of options across a steadily growing number of vehicle applications. This guide provides an overview of alternative fuel power systems--including engines, microturbines, electric motors, and fuel cells--and hybrid propulsion systems. The guide also offers a list of individual medium- and heavy-duty vehicle models listed by application, along with associated manufacturer contact information, fuelmore » type(s), power source(s), and related information.« less

[Alternatives to animal testing].

PubMed

Fabre, Isabelle

2009-11-01

The use of alternative methods to animal testing are an integral part of the 3Rs concept (refine, reduce, replace) defined by Russel & Burch in 1959. These approaches include in silico methods (databases and computer models), in vitro physicochemical analysis, biological methods using bacteria or isolated cells, reconstructed enzyme systems, and reconstructed tissues. Emerging "omic" methods used in integrated approaches further help to reduce animal use, while stem cells offer promising approaches to toxicologic and pathophysiologic studies, along with organotypic cultures and bio-artificial organs. Only a few alternative methods can so far be used in stand-alone tests as substitutes for animal testing. The best way to use these methods is to integrate them in tiered testing strategies (ITS), in which animals are only used as a last resort.

Tree cover in sub-Saharan Africa: rainfall and fire constrain forest and savanna as alternative stable states.

PubMed

Staver, A Carla; Archibald, Sally; Levin, Simon

2011-05-01

Savannas are known as ecosystems with tree cover below climate-defined equilibrium values. However, a predictive framework for understanding constraints on tree cover is lacking. We present (a) a spatially extensive analysis of tree cover and fire distribution in sub-Saharan Africa, and (b) a model, based on empirical results, demonstrating that savanna and forest may be alternative stable states in parts of Africa, with implications for understanding savanna distributions. Tree cover does not increase continuously with rainfall, but rather is constrained to low (<50%, "savanna") or high tree cover (>75%, "forest"). Intermediate tree cover rarely occurs. Fire, which prevents trees from establishing, differentiates high and low tree cover, especially in areas with rainfall between 1000 mm and 2000 mm. Fire is less important at low rainfall (<1000 mm), where rainfall limits tree cover, and at high rainfall (>2000 mm), where fire is rare. This pattern suggests that complex interactions between climate and disturbance produce emergent alternative states in tree cover. The relationship between tree cover and fire was incorporated into a dynamic model including grass, savanna tree saplings, and savanna trees. Only recruitment from sapling to adult tree varied depending on the amount of grass in the system. Based on our empirical analysis and previous work, fires spread only at tree cover of 40% or less, producing a sigmoidal fire probability distribution as a function of grass cover and therefore a sigmoidal sapling to tree recruitment function. This model demonstrates that, given relatively conservative and empirically supported assumptions about the establishment of trees in savannas, alternative stable states for the same set of environmental conditions (i.e., model parameters) are possible via a fire feedback mechanism. Integrating alternative stable state dynamics into models of biome distributions could improve our ability to predict changes in biome distributions and in carbon storage under climate and global change scenarios.

42 CFR § 414.1305 - Definitions.

Code of Federal Regulations, 2010 CFR

2017-10-01

... Payment System and Alternative Payment Model Incentive § 414.1305 Definitions. As used in this section... additional MIPS payment adjustment factors for exceptional performance. Advanced Alternative Payment Model.... Alternative Payment Model (APM) means any of the following: (1) A model under section 1115A of the Act (other...

A Preventive Intervention Program for Urban African American Youth Attending an Alternative Education Program: Background, Implementation, and Feasibility.

PubMed

Carswell, Steven B; Hanlon, Thomas E; O'Grady, Kevin E; Watts, Amy M; Pothong, Pattarapan

2009-01-01

This paper presents background, implementation, and feasibility findings associated with planning and conducting an after-school intervention program in an alternative education setting designed to prevent the initiation and escalation of violence and substance abuse among urban African American youth at high risk for life-long problem behaviors. Evolving from earlier preventive interventions implemented in clinic and school settings, the program, entitled The Village Model of Care, consisted of structured group mentoring, parental support, and community outreach services administered to alternative education students and their primary caregiver(s) during the school year. Over a two-year intake period, 109 youth participated in the present process evaluation study. Findings from the study not only provided relevant demographic information on the characteristics of youth likely to be included in such programs but also indicated the importance of including the family in the rehabilitation effort and the need for school administrative system support for the underlying alternative education approach. The information presented in this report has a direct bearing on the planning of future prevention efforts conducted in similar settings that are aimed at reducing problem behaviors and promoting positive lifestyles among high-risk youth.

[The teaching and application of alternative medicine in medical education programs].

PubMed

Chiang, Han-Sun

2014-12-01

The history of alternative medicine is perhaps as long as the history of human medicine. The development of evidence-based medicine has not annihilated alternative medicine. On the contrary, more people turn to alternative medicine because this approach to treatment serves as an effective remedial or supportive treatment when used in conjunction with evidence-based medicine. In contemporary healthcare, alternative medicine is now an essential part of integrated medicine. In Taiwan, most professional medical practitioners have not received proper education about alternative medicine and therefore generally lack comprehensive knowledge on this subject. While alternative medicine may be effective when used with some patients, it may also impart a placebo effect, which helps restore the body and soul of the patients. Medical staff with advanced knowledge of alternative medicine may not only help patients but also improve the doctor-patient relationship. There is great diversity in alternative medicine, with some alternative therapies supported by evidence and covered by insurance. However, there also remain fraudulent medical practices that may be harmful to health. Medical staff must be properly educated so that they can provide patients and their family a proper understanding and attitude toward alternative medicine. Therefore, alternative medicine should be included in the standard medical education curriculum. Offering classes on alternative medicine in university for more than 10 years, the author shares his experiences regarding potential content, lecture subjects, group experience exercises, and in-class activities. This article is intended to provide a reference to professors in university medical education and offer a possible model for alternative medicine education in Taiwan.

Use of Vendedores (Mobile Food Vendors), Pulgas (Flea Markets), and Vecinos o Amigos (Neighbors or Friends) as Alternative Sources of Food for Purchase among Mexican-origin Households in Texas Border Colonias

PubMed Central

Sharkey, Joseph R.; Dean, Wesley R.; Johnson, Cassandra M.

2012-01-01

There is a paucity of studies acknowledging the existence of alternative food sources, and factors associated with food purchasing from three common alternative sources: vendedores (mobile food vendors), pulgas (flea markets), and vecinos/amigos (neighbors/friends). This analysis aims to examine the use of alternative food sources by Mexican-origin women from Texas-border colonias and determine factors associated with their use. The design was cross-sectional. Promotora-researchers (promotoras de salud trained in research methods) recruited 610 Mexican-origin women from 44 colonias and conducted in-person surveys. Surveys included participant characteristics and measures of food environment use and household food security. Statistical analyses included separate logistic regressions, modeled for food purchase from mobile food vendors, pulgas, or neighbors/friends (NFs). Child food insecurity was associated with purchasing food from mobile food vendors, while household food security was associated with using pulgas or NFs. School nutrition program participants were more likely to live in households that depend on alternative food sources. Efforts to increase healthful food consumption such as fruits and vegetables should acknowledge all potential food sources (traditional, convenience, non-traditional, and alternative), especially those preferred by colonia residents. Current findings support the conceptual broadening of the retail food environment, and the importance of linking use with spatial access (proximity) to more accurately depict access to food sources. PMID:22709775

A cloud model based multi-attribute decision making approach for selection and evaluation of groundwater management schemes

NASA Astrophysics Data System (ADS)

Lu, Hongwei; Ren, Lixia; Chen, Yizhong; Tian, Peipei; Liu, Jia

2017-12-01

Due to the uncertainty (i.e., fuzziness, stochasticity and imprecision) existed simultaneously during the process for groundwater remediation, the accuracy of ranking results obtained by the traditional methods has been limited. This paper proposes a cloud model based multi-attribute decision making framework (CM-MADM) with Monte Carlo for the contaminated-groundwater remediation strategies selection. The cloud model is used to handle imprecise numerical quantities, which can describe the fuzziness and stochasticity of the information fully and precisely. In the proposed approach, the contaminated concentrations are aggregated via the backward cloud generator and the weights of attributes are calculated by employing the weight cloud module. A case study on the remedial alternative selection for a contaminated site suffering from a 1,1,1-trichloroethylene leakage problem in Shanghai, China is conducted to illustrate the efficiency and applicability of the developed approach. Totally, an attribute system which consists of ten attributes were used for evaluating each alternative through the developed method under uncertainty, including daily total pumping rate, total cost and cloud model based health risk. Results indicated that A14 was evaluated to be the most preferred alternative for the 5-year, A5 for the 10-year, A4 for the 15-year and A6 for the 20-year remediation.

Comparison of different synthetic 5-min rainfall time series regarding their suitability for urban drainage modelling

NASA Astrophysics Data System (ADS)

van der Heijden, Sven; Callau Poduje, Ana; Müller, Hannes; Shehu, Bora; Haberlandt, Uwe; Lorenz, Manuel; Wagner, Sven; Kunstmann, Harald; Müller, Thomas; Mosthaf, Tobias; Bárdossy, András

2015-04-01

For the design and operation of urban drainage systems with numerical simulation models, long, continuous precipitation time series with high temporal resolution are necessary. Suitable observed time series are rare. As a result, intelligent design concepts often use uncertain or unsuitable precipitation data, which renders them uneconomic or unsustainable. An expedient alternative to observed data is the use of long, synthetic rainfall time series as input for the simulation models. Within the project SYNOPSE, several different methods to generate synthetic precipitation data for urban drainage modelling are advanced, tested, and compared. The presented study compares four different approaches of precipitation models regarding their ability to reproduce rainfall and runoff characteristics. These include one parametric stochastic model (alternating renewal approach), one non-parametric stochastic model (resampling approach), one downscaling approach from a regional climate model, and one disaggregation approach based on daily precipitation measurements. All four models produce long precipitation time series with a temporal resolution of five minutes. The synthetic time series are first compared to observed rainfall reference time series. Comparison criteria include event based statistics like mean dry spell and wet spell duration, wet spell amount and intensity, long term means of precipitation sum and number of events, and extreme value distributions for different durations. Then they are compared regarding simulated discharge characteristics using an urban hydrological model on a fictitious sewage network. First results show a principal suitability of all rainfall models but with different strengths and weaknesses regarding the different rainfall and runoff characteristics considered.

Evaluation of Generation Alternation Models in Evolutionary Robotics

NASA Astrophysics Data System (ADS)

Oiso, Masashi; Matsumura, Yoshiyuki; Yasuda, Toshiyuki; Ohkura, Kazuhiro

For efficient implementation of Evolutionary Algorithms (EA) to a desktop grid computing environment, we propose a new generation alternation model called Grid-Oriented-Deletion (GOD) based on comparison with the conventional techniques. In previous research, generation alternation models are generally evaluated by using test functions. However, their exploration performance on the real problems such as Evolutionary Robotics (ER) has not been made very clear yet. Therefore we investigate the relationship between the exploration performance of EA on an ER problem and its generation alternation model. We applied four generation alternation models to the Evolutionary Multi-Robotics (EMR), which is the package-pushing problem to investigate their exploration performance. The results show that GOD is more effective than the other conventional models.

Contrasting support for alternative models of genomic variation based on microhabitat preference: species-specific effects of climate change in alpine sedges.

PubMed

Massatti, Rob; Knowles, L Lacey

2016-08-01

Deterministic processes may uniquely affect codistributed species' phylogeographic patterns such that discordant genetic variation among taxa is predicted. Yet, explicitly testing expectations of genomic discordance in a statistical framework remains challenging. Here, we construct spatially and temporally dynamic models to investigate the hypothesized effect of microhabitat preferences on the permeability of glaciated regions to gene flow in two closely related montane species. Utilizing environmental niche models from the Last Glacial Maximum and the present to inform demographic models of changes in habitat suitability over time, we evaluate the relative probabilities of two alternative models using approximate Bayesian computation (ABC) in which glaciated regions are either (i) permeable or (ii) a barrier to gene flow. Results based on the fit of the empirical data to data sets simulated using a spatially explicit coalescent under alternative models indicate that genomic data are consistent with predictions about the hypothesized role of microhabitat in generating discordant patterns of genetic variation among the taxa. Specifically, a model in which glaciated areas acted as a barrier was much more probable based on patterns of genomic variation in Carex nova, a wet-adapted species. However, in the dry-adapted Carex chalciolepis, the permeable model was more probable, although the difference in the support of the models was small. This work highlights how statistical inferences can be used to distinguish deterministic processes that are expected to result in discordant genomic patterns among species, including species-specific responses to climate change. © 2016 John Wiley & Sons Ltd.

Simultaneous modeling of visual saliency and value computation improves predictions of economic choice.

PubMed

Towal, R Blythe; Mormann, Milica; Koch, Christof

2013-10-01

Many decisions we make require visually identifying and evaluating numerous alternatives quickly. These usually vary in reward, or value, and in low-level visual properties, such as saliency. Both saliency and value influence the final decision. In particular, saliency affects fixation locations and durations, which are predictive of choices. However, it is unknown how saliency propagates to the final decision. Moreover, the relative influence of saliency and value is unclear. Here we address these questions with an integrated model that combines a perceptual decision process about where and when to look with an economic decision process about what to choose. The perceptual decision process is modeled as a drift-diffusion model (DDM) process for each alternative. Using psychophysical data from a multiple-alternative, forced-choice task, in which subjects have to pick one food item from a crowded display via eye movements, we test four models where each DDM process is driven by (i) saliency or (ii) value alone or (iii) an additive or (iv) a multiplicative combination of both. We find that models including both saliency and value weighted in a one-third to two-thirds ratio (saliency-to-value) significantly outperform models based on either quantity alone. These eye fixation patterns modulate an economic decision process, also described as a DDM process driven by value. Our combined model quantitatively explains fixation patterns and choices with similar or better accuracy than previous models, suggesting that visual saliency has a smaller, but significant, influence than value and that saliency affects choices indirectly through perceptual decisions that modulate economic decisions.

Simultaneous modeling of visual saliency and value computation improves predictions of economic choice

PubMed Central

Towal, R. Blythe; Mormann, Milica; Koch, Christof

2013-01-01

Many decisions we make require visually identifying and evaluating numerous alternatives quickly. These usually vary in reward, or value, and in low-level visual properties, such as saliency. Both saliency and value influence the final decision. In particular, saliency affects fixation locations and durations, which are predictive of choices. However, it is unknown how saliency propagates to the final decision. Moreover, the relative influence of saliency and value is unclear. Here we address these questions with an integrated model that combines a perceptual decision process about where and when to look with an economic decision process about what to choose. The perceptual decision process is modeled as a drift–diffusion model (DDM) process for each alternative. Using psychophysical data from a multiple-alternative, forced-choice task, in which subjects have to pick one food item from a crowded display via eye movements, we test four models where each DDM process is driven by (i) saliency or (ii) value alone or (iii) an additive or (iv) a multiplicative combination of both. We find that models including both saliency and value weighted in a one-third to two-thirds ratio (saliency-to-value) significantly outperform models based on either quantity alone. These eye fixation patterns modulate an economic decision process, also described as a DDM process driven by value. Our combined model quantitatively explains fixation patterns and choices with similar or better accuracy than previous models, suggesting that visual saliency has a smaller, but significant, influence than value and that saliency affects choices indirectly through perceptual decisions that modulate economic decisions. PMID:24019496

A decision tree model to estimate the value of information provided by a groundwater quality monitoring network

NASA Astrophysics Data System (ADS)

Khader, A. I.; Rosenberg, D. E.; McKee, M.

2013-05-01

Groundwater contaminated with nitrate poses a serious health risk to infants when this contaminated water is used for culinary purposes. To avoid this health risk, people need to know whether their culinary water is contaminated or not. Therefore, there is a need to design an effective groundwater monitoring network, acquire information on groundwater conditions, and use acquired information to inform management options. These actions require time, money, and effort. This paper presents a method to estimate the value of information (VOI) provided by a groundwater quality monitoring network located in an aquifer whose water poses a spatially heterogeneous and uncertain health risk. A decision tree model describes the structure of the decision alternatives facing the decision-maker and the expected outcomes from these alternatives. The alternatives include (i) ignore the health risk of nitrate-contaminated water, (ii) switch to alternative water sources such as bottled water, or (iii) implement a previously designed groundwater quality monitoring network that takes into account uncertainties in aquifer properties, contaminant transport processes, and climate (Khader, 2012). The VOI is estimated as the difference between the expected costs of implementing the monitoring network and the lowest-cost uninformed alternative. We illustrate the method for the Eocene Aquifer, West Bank, Palestine, where methemoglobinemia (blue baby syndrome) is the main health problem associated with the principal contaminant nitrate. The expected cost of each alternative is estimated as the weighted sum of the costs and probabilities (likelihoods) associated with the uncertain outcomes resulting from the alternative. Uncertain outcomes include actual nitrate concentrations in the aquifer, concentrations reported by the monitoring system, whether people abide by manager recommendations to use/not use aquifer water, and whether people get sick from drinking contaminated water. Outcome costs include healthcare for methemoglobinemia, purchase of bottled water, and installation and maintenance of the groundwater monitoring system. At current methemoglobinemia and bottled water costs of 150/person and 0.6/baby/day, the decision tree results show that the expected cost of establishing the proposed groundwater quality monitoring network exceeds the expected costs of the uninformed alternatives and there is no value to the information the monitoring system provides. However, the monitoring system will be preferred to ignoring the health risk or using alternative sources if the methemoglobinemia cost rises to 300/person or the bottled water cost increases to 2.3/baby/day. Similarly, the monitoring system has value if the system can more accurately report actual aquifer concentrations and the public more fully abides by manager recommendations to use/not use the aquifer. The system also has value if it will serve a larger population or if its installation costs can be reduced, for example using a smaller number of monitoring wells. The VOI analysis shows how monitoring system design, accuracy, installation and operating costs, public awareness of health risks, costs of alternatives, and demographics together affect the value of implementing a system to monitor groundwater quality.

A decision tree model to estimate the value of information provided by a groundwater quality monitoring network

NASA Astrophysics Data System (ADS)

Khader, A.; Rosenberg, D.; McKee, M.

2012-12-01

Nitrate pollution poses a health risk for infants whose freshwater drinking source is groundwater. This risk creates a need to design an effective groundwater monitoring network, acquire information on groundwater conditions, and use acquired information to inform management. These actions require time, money, and effort. This paper presents a method to estimate the value of information (VOI) provided by a groundwater quality monitoring network located in an aquifer whose water poses a spatially heterogeneous and uncertain health risk. A decision tree model describes the structure of the decision alternatives facing the decision maker and the expected outcomes from these alternatives. The alternatives include: (i) ignore the health risk of nitrate contaminated water, (ii) switch to alternative water sources such as bottled water, or (iii) implement a previously designed groundwater quality monitoring network that takes into account uncertainties in aquifer properties, pollution transport processes, and climate (Khader and McKee, 2012). The VOI is estimated as the difference between the expected costs of implementing the monitoring network and the lowest-cost uninformed alternative. We illustrate the method for the Eocene Aquifer, West Bank, Palestine where methemoglobinemia is the main health problem associated with the principal pollutant nitrate. The expected cost of each alternative is estimated as the weighted sum of the costs and probabilities (likelihoods) associated with the uncertain outcomes resulting from the alternative. Uncertain outcomes include actual nitrate concentrations in the aquifer, concentrations reported by the monitoring system, whether people abide by manager recommendations to use/not-use aquifer water, and whether people get sick from drinking contaminated water. Outcome costs include healthcare for methemoglobinemia, purchase of bottled water, and installation and maintenance of the groundwater monitoring system. At current methemoglobinemia and bottled water costs of 150 $/person and 0.6 $/baby/day, the decision tree results show that the expected cost of establishing the proposed groundwater quality monitoring network exceeds the expected costs of the uninformed alternatives and there is not value to the information the monitoring system provides. However, the monitoring system will be preferred to ignoring the health risk or using alternative sources if the methemoglobinemia cost rises to 300 $/person or the bottled water cost increases to 2.3 $/baby/day. Similarly, the monitoring system has value if the system can more accurately report actual aquifer concentrations and the public more fully abides by managers' recommendations to use/not use the aquifer. The system also has value if it will serve a larger population or if its installation costs can be reduced, for example using a smaller number of monitoring wells. The VOI analysis shows how monitoring system design, accuracy, installation and operating costs, public awareness of health risks, costs of alternatives, and demographics together affect the value of implementing a system to monitor groundwater quality.

Evaluating cardiac risk: exposure response analysis in early clinical drug development.

PubMed

Grenier, Julie; Paglialunga, Sabina; Morimoto, Bruce H; Lester, Robert M

2018-01-01

The assessment of a drug's cardiac liability has undergone considerable metamorphosis by regulators since International Council for Harmonization of Technical Requirement for Pharmaceuticals for Human Use E14 guideline was introduced in 2005. Drug developers now have a choice in how proarrhythmia risk can be evaluated; the options include a dedicated thorough QT (TQT) study or exposure response (ER) modeling of intensive electrocardiogram (ECG) captured in early clinical development. The alternative approach of ER modeling was incorporated into a guidance document in 2015 as a primary analysis tool which could be utilized in early phase dose escalation studies as an option to perform a dedicated TQT trial. This review will describe the current state of ER modeling of intensive ECG data collected during early clinical drug development; the requirements with regard to the use of a positive control; and address the challenges and opportunities of this alternative approach to assessing QT liability.

The Impact of Alternative Payment Models on Oncology Innovation and Patient Care.

PubMed

Miller, Amy M; Omenn, Gilbert S; Kean, Marcia A

2016-05-15

Oncology care is in a time of major transformation. Scientific discovery is driving breakthroughs in prevention, diagnostics, and treatment, resulting in tremendous gains for patients as the number of cancer survivors continues to grow on an annual basis. At the same time, there is mounting pressure across the healthcare system to contain costs while improving the quality of cancer care. In response to this pressure, private and government payers are increasingly turning to tools such as alternative payment models (APM) and clinical pathways to improve the efficiency of care, inform coverage decisions, and support shared decision-making. As APMs, clinical pathways and other tools are utilized more broadly, it will be critical that these models support the evidence-based use of innovative biomedical advances, including personalized medicine, and deliver patient-centered, high-value care. Clin Cancer Res; 22(10); 2335-41. ©2016 AACR. ©2016 American Association for Cancer Research.

A Roadmap for the Development of Alternative (Non-Animal) Methods for Systemic Toxicity Testing

EPA Science Inventory

Systemic toxicity testing forms the cornerstone for the safety evaluation of substances. Pressures to move from traditional animal models to novel technologies arise from various concerns, including: the need to evaluate large numbers of previously untested chemicals and new prod...

Addressing Gender Equity in Nonfaculty Salaries.

ERIC Educational Resources Information Center

Toukoushian, Robert K.

2000-01-01

Discusses methodology of gender equity studies on noninstructional employees of colleges and universities, including variable selection in the multiple regression model and alternative approaches for measuring wage gaps. Analysis of staff data at one institution finds that experience and market differences account for 80 percent of gender pay…

ENERGY, WATER, AND LAND USE: A FRAMEWORK FOR INCORPORATING SCIENCE INTO SUSTAINABLE REGIONAL PLANNING

EPA Science Inventory

Project outputs will include: 1) the sustainability network and associated web pages; 2) sustainability indicators and associated maps representing the current values of the metrics; 3) an integrated assessment model of the impacts of electricity generation alternatives on a ...

Proceedings of the Symposium Teaching Cardiovascular Physiology Outside the Lecture Hall.

ERIC Educational Resources Information Center

Michael, Joel A.; Rovick, Allen A., Eds.

1983-01-01

Provided are 10 papers presented during a symposium on teaching cardiovascular physiology outside the lecture hall. Topics addressed include a mechanical model of the cardiovascular system for effective teaching, separate course for experiments in cardiovascular physiology, selective laboratory (alternative to cookbook experiments), cardiovascular…

Participation versus Privacy in the Training of Group Counselors.

ERIC Educational Resources Information Center

Pierce, Keith A.; Baldwin, Cynthia

1990-01-01

Examines the process of requiring and evaluating personal growth group participation for students in counselor education programs. Discusses the key components in the dilemma of protecting privacy while evaluating competencies, including ethical practices and program alternatives to avoid evaluation. Proposes a model that will enable participation…

Gifted Education Press Quarterly. Volume 10, 1996.

ERIC Educational Resources Information Center

Gifted Education Press Quarterly, 1996

1996-01-01

This set of four newsletters discusses current issues in gifted education. The first issue includes: "The Underserved Young Gifted Child: Status of Programs and Research" (Joan Smutny); "The Home Education Model: An Alternative Program for the Gifted" (Karen Kendig) and "Jonathan Swift (1667-1745): A Need for Gifted…

Synthesizing Evidence: Synthesis Methods for Evidence Clearinghouses

ERIC Educational Resources Information Center

Valentine, Jeff; Lau, Timothy

2015-01-01

Following the theme of the first two presentations, this presentation will focus on the choices available for research synthesis when summarizing research evidence. The presenters will describe the current research synthesis practice of the What Works Clearinghouse (WWC) as well as several alternative models, including inverse-variance weighted…

Conditional responding is impaired in chronic alcoholics.

PubMed

Hildebrandt, Helmut; Brokate, B; Hoffmann, E; Kröger, B; Eling, P

2006-07-01

Bechara (2003) describes a model for disturbances in executive functions related to addiction. This model involves deficits in decision-making and in suppressing pre-potent representations or response patterns. We tested this model in 29 individuals with long-term heavy alcohol dependency and compared their performance with that of 20 control subjects. Only individuals without memory impairment, with normal intelligence and normal visual response times were included. We examined word fluency, object alternation, spatial stimulus-response incompatibility, extra-dimensional shift learning and decision-making using the Gambling task. We subtracted the performance in a control condition from that of the executive condition, in order to focus specifically on the executive component of each task. Only the object alternation and incompatibility tasks revealed significant differences between the group of alcoholics and the control group. Moreover, response times in the object alternation task correlated with duration of alcohol dependency. The results do not argue in favor of a specific deficit in decision-making or in shifting between relevant representations. We conclude that long-term alcohol abuse leads to an impairment in conditional responding, provided the response depends on former reactions or the inhibition of pre-potent response patterns.

The effect of alternative seismotectonic models on PSHA results - a sensitivity study for two sites in Israel

NASA Astrophysics Data System (ADS)

Avital, Matan; Kamai, Ronnie; Davis, Michael; Dor, Ory

2018-02-01

We present a full probabilistic seismic hazard analysis (PSHA) sensitivity analysis for two sites in southern Israel - one in the near field of a major fault system and one farther away. The PSHA analysis is conducted for alternative source representations, using alternative model parameters for the main seismic sources, such as slip rate and Mmax, among others. The analysis also considers the effect of the ground motion prediction equation (GMPE) on the hazard results. In this way, the two types of epistemic uncertainty - modelling uncertainty and parametric uncertainty - are treated and addressed. We quantify the uncertainty propagation by testing its influence on the final calculated hazard, such that the controlling knowledge gaps are identified and can be treated in future studies. We find that current practice in Israel, as represented by the current version of the building code, grossly underestimates the hazard, by approximately 40 % in short return periods (e.g. 10 % in 50 years) and by as much as 150 % in long return periods (e.g. 10E-5). The analysis shows that this underestimation is most probably due to a combination of factors, including source definitions as well as the GMPE used for analysis.

In Vitro Mimetic Models for the Bone-Cartilage Interface Regeneration.

PubMed

Bicho, Diana; Pina, Sandra; Oliveira, J Miguel; Reis, Rui L

2018-01-01

In embryonic development, pure cartilage structures are in the basis of bone-cartilage interfaces. Despite this fact, the mature bone and cartilage structures can vary greatly in composition and function. Nevertheless, they collaborate in the osteochondral region to create a smooth transition zone that supports the movements and forces resulting from the daily activities. In this sense, all the hierarchical organization is involved in the maintenance and reestablishment of the equilibrium in case of damage. Therefore, this interface has attracted a great deal of interest in order to understand the mechanisms of regeneration or disease progression in osteoarthritis. With that purpose, in vitro tissue models (either static or dynamic) have been studied. Static in vitro tissue models include monocultures, co-cultures, 3D cultures, and ex vivo cultures, mostly cultivated in flat surfaces, while dynamic models involve the use of bioreactors and microfluidic systems. The latter have emerged as alternatives to study the cellular interactions in a more authentic manner over some disadvantages of the static models. The current alternatives of in vitro mimetic models for bone-cartilage interface regeneration are overviewed and discussed herein.

Do Different Mental Models Influence Cybersecurity Behavior? Evaluations via Statistical Reasoning Performance.

PubMed

Brase, Gary L; Vasserman, Eugene Y; Hsu, William

2017-01-01

Cybersecurity research often describes people as understanding internet security in terms of metaphorical mental models (e.g., disease risk, physical security risk, or criminal behavior risk). However, little research has directly evaluated if this is an accurate or productive framework. To assess this question, two experiments asked participants to respond to a statistical reasoning task framed in one of four different contexts (cybersecurity, plus the above alternative models). Each context was also presented using either percentages or natural frequencies, and these tasks were followed by a behavioral likelihood rating. As in previous research, consistent use of natural frequencies promoted correct Bayesian reasoning. There was little indication, however, that any of the alternative mental models generated consistently better understanding or reasoning over the actual cybersecurity context. There was some evidence that different models had some effects on patterns of responses, including the behavioral likelihood ratings, but these effects were small, as compared to the effect of the numerical format manipulation. This points to a need to improve the content of actual internet security warnings, rather than working to change the models users have of warnings.

Do Different Mental Models Influence Cybersecurity Behavior? Evaluations via Statistical Reasoning Performance

PubMed Central

Brase, Gary L.; Vasserman, Eugene Y.; Hsu, William

2017-01-01

Cybersecurity research often describes people as understanding internet security in terms of metaphorical mental models (e.g., disease risk, physical security risk, or criminal behavior risk). However, little research has directly evaluated if this is an accurate or productive framework. To assess this question, two experiments asked participants to respond to a statistical reasoning task framed in one of four different contexts (cybersecurity, plus the above alternative models). Each context was also presented using either percentages or natural frequencies, and these tasks were followed by a behavioral likelihood rating. As in previous research, consistent use of natural frequencies promoted correct Bayesian reasoning. There was little indication, however, that any of the alternative mental models generated consistently better understanding or reasoning over the actual cybersecurity context. There was some evidence that different models had some effects on patterns of responses, including the behavioral likelihood ratings, but these effects were small, as compared to the effect of the numerical format manipulation. This points to a need to improve the content of actual internet security warnings, rather than working to change the models users have of warnings. PMID:29163304

Uncertainty and the Conceptual Site Model

NASA Astrophysics Data System (ADS)

Price, V.; Nicholson, T. J.

2007-12-01

Our focus is on uncertainties in the underlying conceptual framework upon which all subsequent steps in numerical and/or analytical modeling efforts depend. Experienced environmental modelers recognize the value of selecting an optimal conceptual model from several competing site models, but usually do not formally explore possible alternative models, in part due to incomplete or missing site data, as well as relevant regional data for establishing boundary conditions. The value in and approach for developing alternative conceptual site models (CSM) is demonstrated by analysis of case histories. These studies are based on reported flow or transport modeling in which alternative site models are formulated using data that were not available to, or not used by, the original modelers. An important concept inherent to model abstraction of these alternative conceptual models is that it is "Far better an approximate answer to the right question, which is often vague, than the exact answer to the wrong question, which can always be made precise." (Tukey, 1962) The case histories discussed here illustrate the value of formulating alternative models and evaluating them using site-specific data: (1) Charleston Naval Site where seismic characterization data allowed significant revision of the CSM and subsequent contaminant transport modeling; (2) Hanford 300-Area where surface- and ground-water interactions affecting the unsaturated zone suggested an alternative component to the site model; (3) Savannah River C-Area where a characterization report for a waste site within the modeled area was not available to the modelers, but provided significant new information requiring changes to the underlying geologic and hydrogeologic CSM's used; (4) Amargosa Desert Research Site (ADRS) where re-interpretation of resistivity sounding data and water-level data suggested an alternative geologic model. Simple 2-D spreadsheet modeling of the ADRS with the revised CSM provided an improved match to vapor-phase tritium migration. Site-specific monitoring coupled to these alternative CSM's greatly assists in conducting uncertainty assessments. (Work supported by USNRC contract NRC-04-03-061.)

On approaches to analyze the sensitivity of simulated hydrologic fluxes to model parameters in the community land model

DOE PAGES

Bao, Jie; Hou, Zhangshuan; Huang, Maoyi; ...

2015-12-04

Here, effective sensitivity analysis approaches are needed to identify important parameters or factors and their uncertainties in complex Earth system models composed of multi-phase multi-component phenomena and multiple biogeophysical-biogeochemical processes. In this study, the impacts of 10 hydrologic parameters in the Community Land Model on simulations of runoff and latent heat flux are evaluated using data from a watershed. Different metrics, including residual statistics, the Nash-Sutcliffe coefficient, and log mean square error, are used as alternative measures of the deviations between the simulated and field observed values. Four sensitivity analysis (SA) approaches, including analysis of variance based on the generalizedmore » linear model, generalized cross validation based on the multivariate adaptive regression splines model, standardized regression coefficients based on a linear regression model, and analysis of variance based on support vector machine, are investigated. Results suggest that these approaches show consistent measurement of the impacts of major hydrologic parameters on response variables, but with differences in the relative contributions, particularly for the secondary parameters. The convergence behaviors of the SA with respect to the number of sampling points are also examined with different combinations of input parameter sets and output response variables and their alternative metrics. This study helps identify the optimal SA approach, provides guidance for the calibration of the Community Land Model parameters to improve the model simulations of land surface fluxes, and approximates the magnitudes to be adjusted in the parameter values during parametric model optimization.« less

Value-Based Payment Reform and the Medicare Access and Children's Health Insurance Program Reauthorization Act of 2015: A Primer for Plastic Surgeons.

PubMed

Squitieri, Lee; Chung, Kevin C

2017-07-01

In 2015, the U.S. Congress passed the Medicare Access and Children's Health Insurance Program Reauthorization Act, which effectively repealed the Centers for Medicare and Medicaid Services sustainable growth rate formula and established the Centers for Medicare and Medicaid Services Quality Payment Program. The Medicare Access and Children's Health Insurance Program Reauthorization Act represents an unparalleled acceleration toward value-based payment models and a departure from traditional volume-driven fee-for-service reimbursement. The Quality Payment Program includes two paths for provider participation: the Merit-Based Incentive Payment System and Advanced Alternative Payment Models. The Merit-Based Incentive Payment System pathway replaces existing quality reporting programs and adds several new measures to create a composite performance score for each provider (or provider group) that will be used to adjust reimbursed payment. The advanced alternative payment model pathway is available to providers who participate in qualifying Advanced Alternative Payment Models and is associated with an initial 5 percent payment incentive. The first performance period for the Merit-Based Incentive Payment System opens January 1, 2017, and closes on December 31, 2017, and is associated with payment adjustments in January of 2019. The Centers for Medicare and Medicaid Services estimates that the majority of providers will begin participation in 2017 through the Merit-Based Incentive Payment System pathway, but aims to have 50 percent of payments tied to quality or value through Advanced Alternative Payment Models by 2018. In this article, the authors describe key components of the Medicare Access and Children's Health Insurance Program Reauthorization Act to providers navigating through the Quality Payment Program and discuss how plastic surgeons may optimize their performance in this new value-based payment program.

SIM_ADJUST -- A computer code that adjusts simulated equivalents for observations or predictions

USGS Publications Warehouse

Poeter, Eileen P.; Hill, Mary C.

2008-01-01

This report documents the SIM_ADJUST computer code. SIM_ADJUST surmounts an obstacle that is sometimes encountered when using universal model analysis computer codes such as UCODE_2005 (Poeter and others, 2005), PEST (Doherty, 2004), and OSTRICH (Matott, 2005; Fredrick and others (2007). These codes often read simulated equivalents from a list in a file produced by a process model such as MODFLOW that represents a system of interest. At times values needed by the universal code are missing or assigned default values because the process model could not produce a useful solution. SIM_ADJUST can be used to (1) read a file that lists expected observation or prediction names and possible alternatives for the simulated values; (2) read a file produced by a process model that contains space or tab delimited columns, including a column of simulated values and a column of related observation or prediction names; (3) identify observations or predictions that have been omitted or assigned a default value by the process model; and (4) produce an adjusted file that contains a column of simulated values and a column of associated observation or prediction names. The user may provide alternatives that are constant values or that are alternative simulated values. The user may also provide a sequence of alternatives. For example, the heads from a series of cells may be specified to ensure that a meaningful value is available to compare with an observation located in a cell that may become dry. SIM_ADJUST is constructed using modules from the JUPITER API, and is intended for use on any computer operating system. SIM_ADJUST consists of algorithms programmed in Fortran90, which efficiently performs numerical calculations.

ANTI-ULCEROGENIC EFFICACY AND MECHANISMS OF EDIBLE AND NATURAL INGREDIENTS IN NSAID-INDUCED ANIMAL MODELS.

PubMed

Bi, Weiping; Hu, Lizhi; Man, Mao-Qiang

2017-01-01

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews the efficacy and safety of edible natural ingredients in preventing the development of gastric ulcer induced by NSAIDs in animal models. A systematic literature search was conducted on PubMed, using the terms "herbal medicines" and "gastric ulcer", "herbal medicines" and "peptic ulcer", "food" and "peptic ulcer", "food" and "gastric ulcer", "natural ingredient" and "peptic ulcer", "natural ingredient" and "gastric ulcer", "alternative medicine" and "peptic ulcer", "alternative medicine" and "gastric ulcer", "complementary medicine" and "peptic ulcer", "complementary medicine" and "gastric ulcer" in papers published in English between January 1, 1960 and January 31, 2016, resulting in a total of 6146 articles containing these terms. After exclusion of studies not related prevention, not in NSAID model or using non-edible natural ingredients, 54 articles were included in this review. Numerous studies have demonstrated that edible natural ingredients exhibit antiulcerogenic benefit in NSAID-induced animal models. The mechanisms by which edible, ingredient-induced anti-ulcerogenic effects include stimulation of mucous cell proliferation, antioxidation, inhibition of gastric acid secretion, as well as inhibition of H (+), K (+)- ATPase activities. Utilization of edible, natural ingredients could be a safe, valuable alternative to prevent the development of NSAID-induced gastric ulcer, particularly for the subjects who are long-term users of NSAIDs.

Beyond the basics. Effects of the Eden Alternative model on quality of life issues.

PubMed

Bergman-Evans, Brenda

2004-06-01

In Life Worth Living, Thomas (1996) proposed that in long-term care facilities for elderly individuals, loneliness, helplessness, and boredom are out of control and are steadily decaying the residents' spirits, adversely affecting quality of life. While Thomas' contention appeals to common sense, no empirical evidence is offered in its support. The purpose of this quasi-experimental study was to assess the impact of implementation of the Eden Alternative model on levels of loneliness, boredom, and helplessness of older residents of a long-term care facility. The model was introduced into the experimental facility on May 1, 1998. The final sample for the experimental group included 21 cognitively intact older adults from a state veterans home (13 men, 8 women, mean age = 76.1). The final control group was composed of 13 residents in a private long-term care facility (11 women, 2 men, mean age = 85.7). A Background Data Sheet, the Geriatric Depression Scale (includes yes or no questions related to helplessness and boredom), and the UCLA Loneliness Scale (Version 3) were administered by an interviewer at baseline and 1-year post-implementation of the Eden Alternative model. Data analysis from the post-implementation phase revealed significant differences between the groups on levels of boredom (z = -2.6, p = .01) and helplessness (z = -2.2, p = .03). Lower levels of distress were found in the experimental group on both boredom and helplessness, but not loneliness. Findings suggest health care professionals and researchers have an opportunity to take a leading role in impacting services related to quality-of-life issues for this important, but often overlooked, population.

Description and modelling of the solar-hydrogen-biogas-fuel cell system in GlashusEtt

NASA Astrophysics Data System (ADS)

Hedström, L.; Wallmark, C.; Alvfors, P.; Rissanen, M.; Stridh, B.; Ekman, J.

The need to reduce pollutant emissions and utilise the world's available energy resources more efficiently has led to increased attention towards e.g. fuel cells, but also to other alternative energy solutions. In order to further understand and evaluate the prerequisites for sustainable and energy-saving systems, ABB and Fortum have equipped an environmental information centre, located in Hammarby Sjöstad, Stockholm, Sweden, with an alternative energy system. The system is being used to demonstrate and evaluate how a system based on fuel cells and solar cells can function as a complement to existing electricity and heat production. The stationary energy system is situated on the top level of a three-floor glass building and is open to the public. The alternative energy system consists of a fuel cell system, a photovoltaic (PV) cell array, an electrolyser, hydrogen storage tanks, a biogas burner, dc/ac inverters, heat exchangers and an accumulator tank. The fuel cell system includes a reformer and a polymer electrolyte fuel cell (PEFC) with a maximum rated electrical output of 4 kW el and a maximum thermal output of 6.5 kW th. The fuel cell stack can be operated with reformed biogas, or directly using hydrogen produced by the electrolyser. The cell stack in the electrolyser consists of proton exchange membrane (PEM) cells. To evaluate different automatic control strategies for the system, a simplified dynamic model has been developed in MATLAB Simulink. The model based on measurement data taken from the actual system. The evaluation is based on demand curves, investment costs, electricity prices and irradiation. Evaluation criteria included in the model are electrical and total efficiencies as well as economic parameters.

ANTI-ULCEROGENIC EFFICACY AND MECHANISMS OF EDIBLE AND NATURAL INGREDIENTS IN NSAID-INDUCED ANIMAL MODELS

PubMed Central

Bi, Weiping; Hu, Lizhi; Man, Mao-Qiang

2017-01-01

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews the efficacy and safety of edible natural ingredients in preventing the development of gastric ulcer induced by NSAIDs in animal models. Methods: A systematic literature search was conducted on PubMed, using the terms “herbal medicines” and “gastric ulcer”, “herbal medicines” and “peptic ulcer”, “food” and “peptic ulcer”, “food” and “gastric ulcer”, “natural ingredient” and “peptic ulcer”, “natural ingredient” and “gastric ulcer”, “alternative medicine” and “peptic ulcer”, “alternative medicine” and “gastric ulcer”, “complementary medicine” and “peptic ulcer”, “complementary medicine” and “gastric ulcer” in papers published in English between January 1, 1960 and January 31, 2016, resulting in a total of 6146 articles containing these terms. After exclusion of studies not related prevention, not in NSAID model or using non-edible natural ingredients, 54 articles were included in this review. Results: Numerous studies have demonstrated that edible natural ingredients exhibit antiulcerogenic benefit in NSAID-induced animal models. The mechanisms by which edible, ingredient-induced anti-ulcerogenic effects include stimulation of mucous cell proliferation, antioxidation, inhibition of gastric acid secretion, as well as inhibition of H (+), K (+)- ATPase activities. Utilization of edible, natural ingredients could be a safe, valuable alternative to prevent the development of NSAID-induced gastric ulcer, particularly for the subjects who are long-term users of NSAIDs. PMID:28638885

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khangaonkar, Tarang P.; Breithaupt, Stephen A.; Kristanovich, Felix C.

A hydrodynamic and hydrologic modeling analysis was conducted to evaluate the feasibility of restoring natural estuarine functions and tidal marine wetlands habitat in the Chinook River estuary, located near the mouth of the Columbia River in Washington. The reduction in salmonid populations is attributable primarily to the construction of a Highway 101 overpass across the mouth of the Chinook River in the early 1920s with a tide gate under the overpass. This construction, which was designed to eliminate tidal action in the estuary, has impeded the upstream passage of salmonids. The goal of the Chinook River Restoration Project is tomore » restore tidal functions through the estuary, by removing the tide gate at the mouth of the river, filling drainage ditches, restoring tidal swales, and reforesting riparian areas. The hydrologic model (HEC-HMS) was used to compute Chinook River and tributary inflows for use as input to the hydrodynamic model at the project area boundary. The hydrodynamic model (RMA-10) was used to generate information on water levels, velocities, salinity, and inundation during both normal tides and 100-year storm conditions under existing conditions and under the restoration alternatives. The RMA-10 model was extended well upstream of the normal tidal flats into the watershed domain to correctly simulate flooding and drainage with tidal effects included, using the wetting and drying schemes. The major conclusion of the hydrologic and hydrodynamic modeling study was that restoration of the tidal functions in the Chinook River estuary would be feasible through opening or removal of the tide gate. Implementation of the preferred alternative (removal of the tide gate, restoration of the channel under Hwy 101 to a 200-foot width, and construction of an internal levee inside the project area) would provide the required restorations benefits (inundation, habitat, velocities, and salinity penetration, etc.) and meet flood protection requirements. The alternative design included design of storage such that relatively little difference in the drainage or inundation upstream of Chinook River Valley Road would occur as a result of the proposed restoration activities.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khangaonkar, Tarang P.; Breithaupt, Stephen A.; Kristanovich, Felix C.

A hydrodynamic and hydrologic modeling analysis was conducted to evaluate the feasibility of restoring natural estuarine functions and tidal marine wetlands habitat in the Chinook River estuary, located near the mouth of the Columbia River in Washington. The reduction in salmonid populations is attributable primarily to the construction of a Highway 101 overpass across the mouth of the Chinook River in the early 1920s with a tide gate under the overpass. This construction, which was designed to eliminate tidal action in the estuary, has impeded the upstream passage of salmonids. The goal of the Chinook River Restoration Project is tomore » restore tidal functions through the estuary, by removing the tide gate at the mouth of the river, filling drainage ditches, restoring tidal swales, and reforesting riparian areas. The hydrologic model (HEC-HMS) was used to compute Chinook River and tributary inflows for use as input to the hydrodynamic model at the project area boundary. The hydrodynamic model (RMA-10) was used to generate information on water levels, velocities, salinity, and inundation during both normal tides and 100-year storm conditions under existing conditions and under the restoration alternatives. The RMA-10 model was extended well upstream of the normal tidal flats into the watershed domain to correctly simulate flooding anddrainage with tidal effects included, using the wetting and drying schemes. The major conclusion of the hydrologic and hydrodynamic modeling study was that restoration of the tidal functions in the Chinook River estuary would be feasible through opening or removal of the tide gate. Implementation of the preferred alternative (removal of the tide gate, restoration of the channel under Hwy 101 to a 200-foot width, and construction of an internal levee inside the project area) would provide the required restorations benefits (inundation, habitat, velocities, and salinity penetration, etc.) and meet flood protection requirements. The alternative design included design of storage such that relatively little difference in the drainage or inundation upstream of Chinook River Valley Road would occur as a result of the proposed restoration activities.« less

Case Study: Sensitivity Analysis of the Barataria Basin Barrier Shoreline Wetland Value Assessment Model

DTIC Science & Technology

2014-07-01

wetlands in providing resting, foraging , breeding, and nursery habitat to a diverse assemblage of fish and wildlife species in coastal Louisiana (EWG...services, including fish and wildlife production, storm damage reduction, and recreation. Federal, state, and local partners have jointly pursued large...habitat units” (HU) provided by a given alternative. Whereas traditional HEP models focused on specific taxa, WVA assesses the fish and wildlife community

NEMS Freight Transportation Module Improvement Study

EIA Publications

2015-01-01

The U.S. Energy Information Administration (EIA) contracted with IHS Global, Inc. (IHS) to analyze the relationship between the value of industrial output, physical output, and freight movement in the United States for use in updating analytic assumptions and modeling structure within the National Energy Modeling System (NEMS) freight transportation module, including forecasting methodologies and processes to identify possible alternative approaches that would improve multi-modal freight flow and fuel consumption estimation.

The Effects of Local Economic Conditions on Navy Enlistments.

DTIC Science & Technology

1980-03-18

Standard Metropolitan Statistical Area (SMSA) as the basic economic unit, cross-sectional regression models were constructed for enlistment rate, recruiter...to eligible population suggesting that a cheaper alternative to raising mili- tary wages would be to increase the number of recruiters. Arima (1978...is faced with a number of cri- teria that must be satisfied by an acceptable test variable. As with other variables included in the model , economic

Fuels planning: science synthesis and integration; environmental consequences fact sheet 09: Fire and Fuels Extension to the Forest Vegetation Simulator (FFE-FVS)

Treesearch

Elizabeth Reinhardt

2005-01-01

FFE-FVS is a model linking stand development, fuel dynamics, fire behavior and fire effects. It allows comparison of mid- to long-term effects of management alternatives including harvest, mechanical fuel treatment, prescribed fire, salvage, and no action. This fact sheet identifies the intended users and uses, required inputs, what the model does, and tells the user...

An analysis of short haul air passenger demand, volume 2

NASA Technical Reports Server (NTRS)

Blumer, T. P.; Swan, W. M.

1978-01-01

Several demand models for short haul air travel are proposed and calibrated on pooled data. The models are designed to predict demand and analyze some of the motivating phenomena behind demand generation. In particular, an attempt is made to include the effects of competing modes and of alternate destinations. The results support three conclusions: (1) the auto mode is the air mode's major competitor; (2) trip time is an overriding factor in intermodal competition, with air fare at its present level appearing unimportant to the typical short haul air traveler; and (3) distance appears to underly several demand generating phenomena, and therefore, must be considered very carefully to any intercity demand model. It may be the cause of the wide range of fare elasticities reported by researchers over the past 15 years. A behavioral demand model is proposed and calibrated. It combines the travel generating effects of income and population, the effects of modal split, the sensitivity of travel to price and time, and the effect of alternative destinations satisfying the trip purpose.

Determination of spin and parity of the Higgs boson in the [Formula: see text] decay channel with the ATLAS detector.

PubMed

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Chwastowski, J J; Chytka, L; Ciapetti, G; Ciftci, A K; Cinca, D; Cindro, V; Cioara, I A; Ciocio, A; Citron, Z H; Ciubancan, M; Clark, A; Clark, B L; Clark, P J; Clarke, R N; Cleland, W; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Coffey, L; Cogan, J G; Cole, B; Cole, S; Colijn, A P; Collot, J; Colombo, T; Compostella, G; Conde Muiño, P; Coniavitis, E; Connell, S H; Connelly, I A; Consonni, S M; Consorti, V; Constantinescu, S; Conta, C; Conti, G; Conventi, F; Cooke, M; Cooper, B D; Cooper-Sarkar, A M; Copic, K; Cornelissen, T; Corradi, M; Corriveau, F; Corso-Radu, A; Cortes-Gonzalez, A; Cortiana, G; Costa, G; Costa, M J; Costanzo, D; Côté, D; Cottin, G; Cowan, G; Cox, B E; Cranmer, K; Cree, G; Crépé-Renaudin, S; Crescioli, F; Cribbs, W A; Crispin Ortuzar, M; Cristinziani, M; Croft, V; Crosetti, G; Cuhadar Donszelmann, T; Cummings, J; Curatolo, M; Cuthbert, C; Czirr, H; Czodrowski, P; D'Auria, S; D'Onofrio, M; Cunha Sargedas De Sousa, M J Da; Via, C Da; Dabrowski, W; Dafinca, A; 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Pater, J R; Pauly, T; Pearce, J; Pearson, B; Pedersen, L E; Pedersen, M; Pedraza Lopez, S; Pedro, R; Peleganchuk, S V; Pelikan, D; Peng, H; Penning, B; Penwell, J; Perepelitsa, D V; Perez Codina, E; Pérez García-Estañ, M T; Perini, L; Pernegger, H; Perrella, S; Peschke, R; Peshekhonov, V D; Peters, K; Peters, R F Y; Petersen, B A; Petersen, T C; Petit, E; Petridis, A; Petridou, C; Petrolo, E; Petrucci, F; Pettersson, N E; Pezoa, R; Phillips, P W; Piacquadio, G; Pianori, E; Picazio, A; Piccaro, E; Piccinini, M; Pickering, M A; Piegaia, R; Pignotti, D T; Pilcher, J E; Pilkington, A D; Pina, J; Pinamonti, M; Pinfold, J L; Pingel, A; Pinto, B; Pires, S; Pitt, M; Pizio, C; Plazak, L; Pleier, M-A; Pleskot, V; Plotnikova, E; Plucinski, P; Pluth, D; Poettgen, R; Poggioli, L; Pohl, D; Polesello, G; Policicchio, A; Polifka, R; Polini, A; Pollard, C S; Polychronakos, V; Pommès, K; Pontecorvo, L; Pope, B G; Popeneciu, G A; Popovic, D S; Poppleton, A; Pospisil, S; Potamianos, K; Potrap, I N; Potter, C J; 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Simoniello, R; Sinervo, P; Sinev, N B; Siragusa, G; Sisakyan, A N; Sivoklokov, S Yu; Sjölin, J; Sjursen, T B; Skinner, M B; Skottowe, H P; Skubic, P; Slater, M; Slavicek, T; Slawinska, M; Sliwa, K; Smakhtin, V; Smart, B H; Smestad, L; Smirnov, S Yu; Smirnov, Y; Smirnova, L N; Smirnova, O; Smith, M N K; Smizanska, M; Smolek, K; Snesarev, A A; Snidero, G; Snyder, S; Sobie, R; Socher, F; Soffer, A; Soh, D A; Solans, C A; Solar, M; Solc, J; Soldatov, E Yu; Soldevila, U; Solodkov, A A; Soloshenko, A; Solovyanov, O V; Solovyev, V; Sommer, P; Song, H Y; Soni, N; Sood, A; Sopczak, A; Sopko, B; Sopko, V; Sorin, V; Sosa, D; Sosebee, M; Sotiropoulou, C L; Soualah, R; Soueid, P; Soukharev, A M; South, D; Spagnolo, S; Spalla, M; Spanò, F; Spearman, W R; Spettel, F; Spighi, R; Spigo, G; Spiller, L A; Spousta, M; Spreitzer, T; Denis, R D St; Staerz, S; Stahlman, J; Stamen, R; Stamm, S; Stanecka, E; Stanescu, C; Stanescu-Bellu, M; Stanitzki, M M; Stapnes, S; Starchenko, E A; Stark, J; Staroba, P; Starovoitov, P; 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Studies of the spin and parity quantum numbers of the Higgs boson in the [Formula: see text] final state are presented, based on proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb[Formula: see text] at a centre-of-mass energy of [Formula: see text] TeV. The Standard Model spin-parity [Formula: see text] hypothesis is compared with alternative hypotheses for both spin and CP. The case where the observed resonance is a mixture of the Standard-Model-like Higgs boson and CP-even ([Formula: see text]) or CP-odd ([Formula: see text]) Higgs boson in scenarios beyond the Standard Model is also studied. The data are found to be consistent with the Standard Model prediction and limits are placed on alternative spin and CP hypotheses, including CP mixing in different scenarios.

Approximate Stokes Drift Profiles and their use in Ocean Modelling

NASA Astrophysics Data System (ADS)

Breivik, O.; Biblot, J.; Janssen, P. A. E. M.

2016-02-01

Deep-water approximations to the Stokes drift velocity profile are explored as alternatives to the monochromatic profile. The alternative profiles investigated rely on the same two quantities required for the monochromatic profile, viz the Stokes transport and the surface Stokes drift velocity. Comparisons with parametric spectra and profiles under wave spectra from the ERA-Interim reanalysis and buoy observations reveal much better agreement than the monochromatic profile even for complex sea states. That the profiles give a closer match and a more correct shear has implications for ocean circulation models since the Coriolis-Stokes force depends on the magnitude and direction of the Stokes drift profile and Langmuir turbulence parameterizations depend sensitively on the shear of the profile. The NEMO general circulation ocean model was recently extended to incorporate the Stokes-Coriolis force along with two other wave-related effects. I will show some results from the coupled atmosphere-wave-ocean ensemble forecast system of ECMWF where these wave effects are now included in the ocean model component.

Maximum mutual information estimation of a simplified hidden MRF for offline handwritten Chinese character recognition

NASA Astrophysics Data System (ADS)

Xiong, Yan; Reichenbach, Stephen E.

1999-01-01

Understanding of hand-written Chinese characters is at such a primitive stage that models include some assumptions about hand-written Chinese characters that are simply false. So Maximum Likelihood Estimation (MLE) may not be an optimal method for hand-written Chinese characters recognition. This concern motivates the research effort to consider alternative criteria. Maximum Mutual Information Estimation (MMIE) is an alternative method for parameter estimation that does not derive its rationale from presumed model correctness, but instead examines the pattern-modeling problem in automatic recognition system from an information- theoretic point of view. The objective of MMIE is to find a set of parameters in such that the resultant model allows the system to derive from the observed data as much information as possible about the class. We consider MMIE for recognition of hand-written Chinese characters using on a simplified hidden Markov Random Field. MMIE provides improved performance improvement over MLE in this application.

Determination of spin and parity of the Higgs boson in the $$WW^*\\rightarrow e \

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2015-05-27

Research of the spin and parity quantum numbers of the Higgs boson in the WW* → eνμν final state are presented, based on proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb –1 at a centre-of-mass energy of √s=8 TeV. The Standard Model spin-parity J CP=0 ++ hypothesis is compared with alternative hypotheses for both spin and CP. The case where the observed resonance is a mixture of the Standard-Model-like Higgs boson and CP-even (J CP=0 ++) or CP-odd (J CP=0 +–) Higgs boson in scenarios beyond themore » Standard Model is also studied. The data are found to be consistent with the Standard Model prediction and limits are placed on alternative spin and CP hypotheses, including CP mixing in different scenarios.« less

Determination of spin and parity of the Higgs boson in the $$WW^*\\rightarrow e \

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aad, G.; Abbott, B.; Abdallah, J.

Research of the spin and parity quantum numbers of the Higgs boson in the WW* → eνμν final state are presented, based on proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb –1 at a centre-of-mass energy of √s=8 TeV. The Standard Model spin-parity J CP=0 ++ hypothesis is compared with alternative hypotheses for both spin and CP. The case where the observed resonance is a mixture of the Standard-Model-like Higgs boson and CP-even (J CP=0 ++) or CP-odd (J CP=0 +–) Higgs boson in scenarios beyond themore » Standard Model is also studied. The data are found to be consistent with the Standard Model prediction and limits are placed on alternative spin and CP hypotheses, including CP mixing in different scenarios.« less

Geometrically nonlinear analysis of laminated elastic structures

NASA Technical Reports Server (NTRS)

Reddy, J. N.

1984-01-01

Laminated composite plates and shells that can be used to model automobile bodies, aircraft wings and fuselages, and pressure vessels among many other were analyzed. The finite element method, a numerical technique for engineering analysis of structures, is used to model the geometry and approximate the solution. Various alternative formulations for analyzing laminated plates and shells are developed and their finite element models are tested for accuracy and economy in computation. These include the shear deformation laminate theory and degenerated 3-D elasticity theory for laminates.

Modeling the human mental lexicon with self-organizing feature maps

NASA Astrophysics Data System (ADS)

Wittenburg, Peter; Frauenfelder, Uli H.

1992-10-01

Recent efforts to model the remarkable ability of humans to recognize speech and words are described. Different techniques including the use of neural nets for representing phonological similarity between words in the lexicon with self organizing algorithms are discussed. Simulations using the standard Kohonen algorithm are presented to illustrate some problems confronted with this technique in modeling similarity relations of form in the human mental lexicon. Alternative approaches that can potentially deal with some of these limitations are sketched.

Winter Simulation Conference, Miami Beach, Fla., December 4-6, 1978, Proceedings. Volumes 1 & 2

NASA Technical Reports Server (NTRS)

Highland, H. J. (Editor); Nielsen, N. R.; Hull, L. G.

1978-01-01

The papers report on the various aspects of simulation such as random variate generation, simulation optimization, ranking and selection of alternatives, model management, documentation, data bases, and instructional methods. Simulation studies in a wide variety of fields are described, including system design and scheduling, government and social systems, agriculture, computer systems, the military, transportation, corporate planning, ecosystems, health care, manufacturing and industrial systems, computer networks, education, energy, production planning and control, financial models, behavioral models, information systems, and inventory control.

Alternative stable states and alternative endstates of community assembly through intra- and interspecific positive and negative interactions.

PubMed

Gerla, Daan J; Mooij, Wolf M

2014-09-01

Positive and negative interactions within and between species may occur simultaneously, with the net effect depending on population densities. For instance, at low densities plants may ameliorate stress, while competition for resources dominates at higher densities. Here, we propose a simple two-species model in which con- and heterospecifics have a positive effect on per capita growth rate at low densities, while negative interactions dominate at high densities. The model thus includes both Allee effects (intraspecific positive effects) and mutualism (interspecific positive effects), as well as intra- and interspecific competition. Using graphical methods we derive conditions for alternative stable states and species coexistence. We show that mutual non-invasibility (i.e. the inability of each species to invade a population of the other) is more likely when species have a strong positive effect on the own species or a strong negative effect on the other species. Mutual non-invasibility implies alternative stable states, however, there may also be alternative stable states at which species coexist. In the case of species symmetry (i.e. when species are indistinguishable), such alternative coexistence states require that if the positive effect exerted at low densities at the own species is stronger than on the other species, the negative effect at higher densities is also stronger on the own species than on the other species, or, vice versa, if the interspecific positive effects at low densities are stronger than the intraspecific effects, the negative effects at higher densities are also stronger between species than within species. However, the reachability of alternative stable states is restricted by the frequency and density at which species are introduced during community assembly, so that alternative stable states do not always represent alternative endstates of community assembly. Copyright © 2014 Elsevier Inc. All rights reserved.

The relationship between buccofacial and limb apraxia.

PubMed

Raade, A S; Rothi, L J; Heilman, K M

1991-07-01

There are at least two possible models depicting the relationship between buccofacial and limb apraxia. First, apraxia can be viewed as a unitary motor disorder which transcends the output modalities of both buccofacial and limb output. A high degree of similarity between the two types of apraxia would support this model. Alternatively, the relationship between buccofacial and limb apraxia may not include a unitary mechanism. The presence of quantitative and qualitative differences between buccofacial and limb performance would support this nonunitary model. The results of the present study support the nonunitary model.

Seventeen-year follow-up of the prospective randomized Nordic CIS study: BCG monotherapy versus alternating therapy with mitomycin C and BCG in patients with carcinoma in situ of the urinary bladder.

PubMed

Kaasinen, Eero; Wijkström, Hans; Rintala, Erkki; Mestad, Oddvar; Jahnson, Staffan; Malmström, Per-Uno

2016-10-01

The aim of this study was to compare the long-term efficacy of BCG monotherapy to alternating therapy of mitomycin C (MMC) and BCG in patients with carcinoma in situ (CIS). Between 1992 and 1997, 321 patients with CIS were randomized from Finland, Norway and Sweden in a prospective multicenter trial into two treatment groups. The alternating therapy comprised six weekly instillations of MMC 40 mg followed by 10 instillations of BCG (Connaught 120 mg) or MMC alternating monthly for 1 year. BCG monotherapy followed the same 6 + 10 schedule. Stratification was done by nationality and CIS category. Primary endpoints were time to first recurrence and time to progression. Secondary endpoints were disease-specific mortality and overall survival. The main statistical methods were the proportional subdistribution hazards model and Cox proportional hazards model with the cumulative incidence and Kaplan-Meier analyses. The median follow-up time was 9.9 years (maximum 19.9 years) in the BCG group and 8.9 years (maximum 20.3 years) in the alternating group. The risk of recurrence was significantly lower in the BCG group than in the alternating group (49 vs 59% at 15 years, respectively; hazard ratio 0.74, 95% confidence interval 0.54-1.00, p = 0.048). There were no significant differences in the other endpoints. Patients who progressed after 2 years were particularly prone to dying from bladder carcinoma. Younger patients performed worse than older ones. BCG monotherapy including monthly maintenance was effective and better than the alternating therapy. The risk of dying from bladder carcinoma after progression was high.

Does the context of reinforcement affect resistance to change?

PubMed

Nevin, J A; Grace, R C

1999-04-01

Eight pigeons were trained on multiple schedules of reinforcement where pairs of components alternated in blocks on different keys to define 2 local contexts. On 1 key, components arranged 160 and 40 reinforcers/hr; on the other, components arranged 40 and 10 reinforcers/hr. Response rates in the 40/hr component were higher in the latter pair. Within pairs, resistance to prefeeding and resistance to extinction were generally greater in the richer component. The two 40/hr components did not differ in resistance to prefeeding, but the 40/hr component that alternated with 10/hr was more resistant to extinction. This discrepancy was interpreted by an algebraic model relating response strength to component reinforcer rate, including generalization decrement. According to this model, strength is independent of context, consistent with research on schedule preference.

TSAPA: identification of tissue-specific alternative polyadenylation sites in plants.

PubMed

Ji, Guoli; Chen, Moliang; Ye, Wenbin; Zhu, Sheng; Ye, Congting; Su, Yaru; Peng, Haonan; Wu, Xiaohui

2018-06-15

Alternative polyadenylation (APA) is now emerging as a widespread mechanism modulated tissue-specifically, which highlights the need to define tissue-specific poly(A) sites for profiling APA dynamics across tissues. We have developed an R package called TSAPA based on the machine learning model for identifying tissue-specific poly(A) sites in plants. A feature space including more than 200 features was assembled to specifically characterize poly(A) sites in plants. The classification model in TSAPA can be customized by selecting desirable features or classifiers. TSAPA is also capable of predicting tissue-specific poly(A) sites in unannotated intergenic regions. TSAPA will be a valuable addition to the community for studying dynamics of APA in plants. https://github.com/BMILAB/TSAPA. Supplementary data are available at Bioinformatics online.

An Integrated Hydrologic-Economic Modeling Tool for Evaluating Water Management Responses to Climate Change in the Boise River Basin

NASA Astrophysics Data System (ADS)

Schmidt, R. D.; Taylor, R. G.; Stodick, L. D.; Contor, B. A.

2009-12-01

A recent federal interagency report on climate change and water management (Brekke et. al., 2009) describes several possible management responses to the impacts of climate change on water supply and demand. Management alternatives include changes to water supply infrastructure, reservoir system operations, and water demand policies. Water users in the Bureau of Reclamation’s Boise Project (located in the Lower Boise River basin in southwestern Idaho) would be among those impacted both hydrologically and economically by climate change. Climate change and management responses to climate change are expected to cause shifts in water supply and demand. Supply shifts would result from changes in basin precipitation patterns, and demand shifts would result from higher evapotranspiration rates and a longer growing season. The impacts would also extend to non-Project water users in the basin, since most non-Project groundwater pumpers and drain water diverters rely on hydrologic externalities created by seepage losses from Boise Project water deliveries. An integrated hydrologic-economic model was developed for the Boise basin to aid Reclamation in evaluating the hydrologic and economic impacts of various management responses to climate change. A spatial, partial-equilibrium, economic optimization model calculates spatially-distinct equilibrium water prices and quantities, and maximizes a social welfare function (the sum of consumer and producers surpluses) for all agricultural and municipal water suppliers and demanders (both Project and non-Project) in the basin. Supply-price functions and demand-price functions are exogenous inputs to the economic optimization model. On the supply side, groundwater and river/reservoir models are used to generate hydrologic responses to various management alternatives. The response data is then used to develop water supply-price functions for Project and non-Project water users. On the demand side, crop production functions incorporating crop distribution, evapotranspiration rates, irrigation efficiencies, and crop prices are used to develop water demand-price functions for agricultural water users. Demand functions for municipal and industrial water users are also developed. Recent applications of the integrated model have focused on the hydrologic and economic impacts of demand management alternatives, including large-scale canal lining conservation measures, and market-based water trading between canal diverters and groundwater pumpers. A supply management alternative being investigated involves revising reservoir rule curves to compensate for climate change impacts on timing of reservoir filling.

Exploring the Assessment of the DSM-5 Alternative Model for Personality Disorders With the Personality Assessment Inventory.

PubMed

Busch, Alexander J; Morey, Leslie C; Hopwood, Christopher J

2017-01-01

Section III of the Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]; American Psychiatric Association, 2013) contains an alternative model for the diagnosis of personality disorder involving the assessment of 25 traits and a global level of overall personality functioning. There is hope that this model will be increasingly used in clinical and research settings, and the ability to apply established instruments to assess these concepts could facilitate this process. This study sought to develop scoring algorithms for these alternative model concepts using scales from the Personality Assessment Inventory (PAI). A multiple regression strategy used to predict scores in 2 undergraduate samples on DSM-5 alternative model instruments: the Personality Inventory for the DSM-5 (PID-5) and the General Personality Pathology scale (GPP; Morey et al., 2011 ). These regression functions resulted in scores that demonstrated promising convergent and discriminant validity across the alternative model concepts, as well as a factor structure in a cross-validation sample that was congruent with the putative structure of the alternative model traits. Results were linked to the PAI community normative data to provide normative information regarding these alternative model concepts that can be used to identify elevated traits and personality functioning level scores.

Understanding Market Concentration: Internet-Based Applications from the Banking Industry

ERIC Educational Resources Information Center

Hays, Fred H.; Ward, Sidne Gail

2011-01-01

Market structure is an essential topic in economics and finance courses, including bank management as well as many other business school courses, for example marketing, human resources and strategic management. Instructors explain the virtues of perfect competition and the evils of monopoly along with alternative market models. Often conversations…

Analysis of Costs and Benefits in Rehabilitation. Final Report.

ERIC Educational Resources Information Center

Berkowitz, Monroe, Ed.; And Others

This report suggests feasible alternatives to the present methods of calculating benefits and costs of the joint federal-state vocational rehabilitation program. "Summary and Guide to Reading This Report" (Monroe Berkowitz) appears first. Part I, Background, Theory and Models, includes "The Cost Benefit Tradition in Vocational Rehabilitation"…

42 CFR § 414.1455 - Limitation on review.

Code of Federal Regulations, 2010 CFR

2017-10-01

... (CONTINUED) MEDICARE PROGRAM (CONTINUED) PAYMENT FOR PART B MEDICAL AND OTHER HEALTH SERVICES Merit-Based Incentive Payment System and Alternative Payment Model Incentive § 414.1455 Limitation on review. There is... of the APM Incentive Payment under § 414.1450, including any estimation as part of such determination. ...

Cultural Exchange: Evaluating an Alternative Model in Higher Education

ERIC Educational Resources Information Center

DeLong, Marilyn; Geum, KeySook; Gage, Kelly; McKinney, Ellen; Medvedev, Katalin; Park, Juyeon

2011-01-01

A fundamental and contemporary issue in higher education is how to encourage global awareness, professional development, and accountability within constraints of curriculum and scarce resources. This is an evaluation of student experiences with a 1 1/2-year cross-cultural partnership that included a team project, public presentations,…

Role of Metabolomics in Environmental Chemical Exposure and Risk Assessment

EPA Science Inventory

The increasing demand for the reduction, replacement, and refinement of the use of animal models in exposure assessments has stimulated the pursuit of alternative methods. This has included not only the use of the in vitro systems (e.g., cell cultures) in lieu of in vivo whole an...

The Organization as Client: Broadening the Concept of Employee Assistance Programs.

ERIC Educational Resources Information Center

Googins, Bradley; Davidson, Bruce N.

1993-01-01

Notes that many employee assistance programs (EAPs) are broadening their function to address rapidly changing human and social issues of environments in which they operate, refocusing practice to include organization as the client. Discusses traditional EAP practice, evolution of EAPs, changes confronting corporations, and alternative model in…

ASHE Reader in Organization and Governance in Higher Education. Revised Edition.

ERIC Educational Resources Information Center

Birnbaum, Robert, Ed.

Supplementary text materials for graduate courses in the field of higher education are presented in 29 chapters on organization, governance, and internal and external constraints on governance. Chapter titles and authors include: "Alternative Models of Governance in Higher Education" (J. Victor Baldridge, David V. Curtis, George P.…

Algorithms for Mathematical Programming with Emphasis on Bi-level Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldfarb, Donald; Iyengar, Garud

2014-05-22

The research supported by this grant was focused primarily on first-order methods for solving large scale and structured convex optimization problems and convex relaxations of nonconvex problems. These include optimal gradient methods, operator and variable splitting methods, alternating direction augmented Lagrangian methods, and block coordinate descent methods.

Comparative sensitivity of human and rat neural cultures to chemical-induced inhibition of neurite outgrowth

EPA Science Inventory

There is a need for rapid, efficient and cost effective alternatives to traditional in vivo developmental neurotoxicity testing. In vitro cell culture models can recapitulate many of the key cellular processes of nervous system development, including neurite outgrowth, and may be...

Computer model of Raritan River Basin water-supply system in central New Jersey

USGS Publications Warehouse

Dunne, Paul; Tasker, Gary D.

1996-01-01

This report describes a computer model of the Raritan River Basin water-supply system in central New Jersey. The computer model provides a technical basis for evaluating the effects of alternative patterns of operation of the Raritan River Basin water-supply system during extended periods of below-average precipitation. The computer model is a continuity-accounting model consisting of a series of interconnected nodes. At each node, the inflow volume, outflow volume, and change in storage are determined and recorded for each month. The model runs with a given set of operating rules and water-use requirements including releases, pumpages, and diversions. The model can be used to assess the hypothetical performance of the Raritan River Basin water- supply system in past years under alternative sets of operating rules. It also can be used to forecast the likelihood of specified outcomes, such as the depletion of reservoir contents below a specified threshold or of streamflows below statutory minimum passing flows, for a period of up to 12 months. The model was constructed on the basis of current reservoir capacities and the natural, unregulated monthly runoff values recorded at U.S. Geological Survey streamflow- gaging stations in the basin.

Evaluating Behavioral Economic Models of Heavy Drinking Among College Students.

PubMed

Acuff, Samuel F; Soltis, Kathryn E; Dennhardt, Ashley A; Berlin, Kristoffer S; Murphy, James G

2018-05-14

Heavy drinking among college students is a significant public health concern that can lead to profound social and health consequences, including alcohol use disorder. Behavioral economics posits that low future orientation and high valuation of alcohol (alcohol demand) combined with deficits in alternative reinforcement increase the likelihood of alcohol misuse (Bickel et al., 2011). Despite this, no study has examined the incremental utility of all three variables simultaneously in a comprehensive model METHOD: The current study uses structural equation modeling to test the associations between behavioral economic variables - alcohol demand (latent), future orientation (measured with a delay discounting task and the Consideration of Future Consequences (CFC) scale), and proportionate substance-related reinforcement - and alcohol consumption and problems among 393 heavy drinking college students. Two models are tested: 1) an iteration of the reinforcer pathology model that includes an interaction between future orientation and alcohol demand; and 2) an alternative model evaluating the interconnectedness of behavioral economic variables in predicting problematic alcohol use RESULTS: The interaction effects in model 1 were nonsignificant. Model 2 suggests that greater alcohol demand and proportionate substance-related reinforcement is associated with greater alcohol consumption and problems. Further, CFC was associated with alcohol-related problems and lower proportionate substance-related reinforcement but was not significantly associated with alcohol consumption or alcohol demand. Finally, greater proportionate substance-related reinforcement was associated with greater alcohol demand CONCLUSIONS: Our results support the validity of the behavioral economic reinforcer pathology model as applied to young adult heavy drinking. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Air Quality and Population Exposure in Urban Areas: Potential Co-Benefits of Alternative Strategies

NASA Astrophysics Data System (ADS)

Mikolajczyk, U.; Suppan, P.; Forkel, R.; Williams, M.

2014-12-01

Even though much progress has been achieved through dedicated approaches to improving air quality in many European cities, there are various threats which still remain unchanged. According to the World Health Organization, outdoor air pollution was linked to 3.7 million deaths in year 2012. As climate changes, the frequency of days with harmful levels of air pollutants may significantly increase causing exacerbation of cardiovascular and respiratory diseases. The aim of this study is to conduct health impact assessment by utilizing regionally and spatially specific data in order to assess the influence of alternative emission strategies on human health. In the first stage of this investigation, a modeling study was carried out using the Weather Research and Forecasting (WRF) model coupled with Chemistry (WRF/Chem; Grell et al., 2005) to estimate ambient concentrations of air pollutants. The model set-up included a nesting approach, where three domains with horizontal resolution of 18 km, 6 km and 2 km were defined. The investigation area included the city of Munich (1.5 million inhabitants). The model performance has been evaluated against available air quality observations from the monitoring database "AirBase". The chemical species including O3, NO, NO2 and PM10 simulated by WRF/Chem compare favorably with the observations. The model performs especially well in resolving the observed O3 concentrations. In the ongoing study, different emission reduction scenarios are compared to a baseline 2009 scenario based on Germany's National Emissions Inventory. To investigate health effects associated with air pollution concentrations a local-scale health impact assessment (HIA) will be conducted. Concentration-response functions (CRFs) link the change in mortality rates to the change in concentrations of air pollutants. CRFs are applied to population-weighted mean concentrations to estimate relative risks and hence estimate numbers of attributable deaths and associated life-years lost. The health benefits that we assume with introducing alternative air quality strategies can be used to provide options for future policy decisions to achieve the reduction of emissions and thereby premature deaths.

The imperative for emergency medicine to create its own alternative payment model.

PubMed

Medford-Davis, Laura N

2017-06-01

Seven years after the Affordable Care Act legislated Alternative Payment Models, it is time for Emergency Medicine to find its place within this value-based trend by developing its own Alternative Payment Model. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of error covariance structure on estimation of model averaging weights and predictive performance

USGS Publications Warehouse

Lu, Dan; Ye, Ming; Meyer, Philip D.; Curtis, Gary P.; Shi, Xiaoqing; Niu, Xu-Feng; Yabusaki, Steve B.

2013-01-01

When conducting model averaging for assessing groundwater conceptual model uncertainty, the averaging weights are often evaluated using model selection criteria such as AIC, AICc, BIC, and KIC (Akaike Information Criterion, Corrected Akaike Information Criterion, Bayesian Information Criterion, and Kashyap Information Criterion, respectively). However, this method often leads to an unrealistic situation in which the best model receives overwhelmingly large averaging weight (close to 100%), which cannot be justified by available data and knowledge. It was found in this study that this problem was caused by using the covariance matrix, CE, of measurement errors for estimating the negative log likelihood function common to all the model selection criteria. This problem can be resolved by using the covariance matrix, Cek, of total errors (including model errors and measurement errors) to account for the correlation between the total errors. An iterative two-stage method was developed in the context of maximum likelihood inverse modeling to iteratively infer the unknown Cek from the residuals during model calibration. The inferred Cek was then used in the evaluation of model selection criteria and model averaging weights. While this method was limited to serial data using time series techniques in this study, it can be extended to spatial data using geostatistical techniques. The method was first evaluated in a synthetic study and then applied to an experimental study, in which alternative surface complexation models were developed to simulate column experiments of uranium reactive transport. It was found that the total errors of the alternative models were temporally correlated due to the model errors. The iterative two-stage method using Cekresolved the problem that the best model receives 100% model averaging weight, and the resulting model averaging weights were supported by the calibration results and physical understanding of the alternative models. Using Cek obtained from the iterative two-stage method also improved predictive performance of the individual models and model averaging in both synthetic and experimental studies.

Modelling biogas production of solid waste: application of the BGP model to a synthetic landfill

NASA Astrophysics Data System (ADS)

Rodrigo-Ilarri, Javier; Segura-Sobrino, Francisco

2013-04-01

Production of biogas as a result of the decomposition of organic matter included on solid waste landfills is still an issue to be understood. Reports on this matter are rarely included on the engineering construction projects of solid waste landfills despite it can be an issue of critical importance while operating the landfill and after its closure. This paper presents an application of BGP (Bio-Gas-Production) model to a synthetic landfill. The evolution in time of the concentrations of the different chemical compounds of biogas is studied. Results obtained show the impact on the air quality of different management alternatives which are usually performed in real landfills.

Venus spherical harmonic gravity model to degree and order 60

NASA Technical Reports Server (NTRS)

Konopliv, Alex S.; Sjogren, William L.

1994-01-01

The Magellan and Pioneer Venus Orbiter radiometric tracking data sets have been combined to produce a 60th degree and order spherical harmonic gravity field. The Magellan data include the high-precision X-band gravity tracking from September 1992 to May 1993 and post-aerobraking data up to January 5, 1994. Gravity models are presented from the application of Kaula's power rule for Venus and an alternative a priori method using surface accelerations. Results are given as vertical gravity acceleration at the reference surface, geoid, vertical Bouguer, and vertical isostatic maps with errors for the vertical gravity and geoid maps included. Correlation of the gravity with topography for the different models is also discussed.

Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing

PubMed Central

Seals, Douglas R.

2016-01-01

Abstract Calorie restriction (CR) in the absence of malnutrition exerts a multitude of physiological benefits with ageing in model organisms and in humans including improvements in vascular function. Despite the well‐known benefits of chronic CR, long‐term energy restriction is not likely to be a feasible healthy lifestyle strategy in humans due to poor sustained adherence, and presents additional concerns if applied to normal weight older adults. This review summarizes what is known about the effects of CR on vascular function with ageing including the underlying molecular ‘energy‐ and nutrient‐sensing’ mechanisms, and discusses the limited but encouraging evidence for alternative pharmacological and lifestyle interventions that may improve vascular function with ageing by mimicking the beneficial effects of long‐term CR. PMID:27641062

Synchronous, Alternating, and Phase-Locked Stridulation by a Tropical Katydid

NASA Astrophysics Data System (ADS)

Sismondo, Enrico

1990-07-01

In the field the chirps of neighboring Mecopoda sp. (Orthoptera, Tettigoniidae, and Mecopodinae) males are normally synchronized, but between more distant individuals the chirps are either synchronous or regularly alternating. The phase response to single-stimulus chirps depends on both the phase and the intensity of the stimulus. Iteration of the Poincare map of the phase response predicts a variety of phase-locked synchronization regimes, including period-doubling bifurcations, in close agreement with experimental observations. The versatile acoustic behavior of Mecopoda encompasses most of the phenomena found in other synchronizing insects and thus provides a general model of insect synchronization behavior.

An Alternative Proposal for the Graphical Representation of Anticolor Charge

NASA Astrophysics Data System (ADS)

Wiener, Gerfried J.; Schmeling, Sascha M.; Hopf, Martin

2017-11-01

We have developed a learning unit based on the Standard Model of particle physics, featuring novel typographic illustrations of elementary particles and particle systems. Since the unit includes antiparticles and systems of antiparticles, a visualization of anticolor charge was required. We propose an alternative to the commonly used complementary-color method, whereby antiparticles and antiparticle systems are identified through the use of stripes instead of a change in color. We presented our proposal to high school students and physics teachers, who evaluated it to be a more helpful way of distinguishing between color charge and anticolor charge.

Unintended Consequences in Cancer Care Delivery Created by the Medicare Part B Proposal: Is the Clinical Rationale for the Experiment Flawed?

PubMed

Gordan, Lucio; Grogg, Amy; Blazer, Marlo; Fortner, Barry

2017-02-01

Medicare currently enrolls ≥ 45 million adults, and by 2030 this is projected to increase to ≥ 80 million beneficiaries. With this growth, the Centers for Medicare & Medicaid Services (CMS) issued a proposal, the Medicare Part B Drug Payment Model, to shrink drug expenditures, a major contributor to overall health care costs. For this to not adversely affect patient outcomes, lower-cost alternative medications with equivalent efficacy and no increased toxicity must be available. This is often not true in the treatment of cancer. Herein, we examine the flaws in the rationale of the CMS and the potential unintended consequences of this experiment. We identified the top three oncology expenditures (rituximab, bevacizumab, and trastuzumab) and their vetted alternatives (per the National Comprehensive Cancer Network guidelines) to ascertain whether lower-cost equivalent alternatives are available. Drug cost was based on April 2016 average sale price. We explored both efficacy of the agents and, when applicable, toxicity to compare alternatives to these high-dollar medications. For the largest Medicare oncology drug expenditures, there is not a lower-cost option with equal efficacy for their primary indications. Without lower-cost alternatives, the unintended consequence of this CMS experiment may include curtailing access to care or an increase in patient/program costs. The CMS proposal, by simply lowering reimbursement for drugs, does not acknowledge the value of these agents and could unintentionally reduce quality of care. Alternative approaches to value-based care, such as the Oncology Care Model and similar frameworks, should be explored.

The acceptance of in silico models for REACH: Requirements, barriers, and perspectives

PubMed Central

2011-01-01

In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR) models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes. PMID:21982269

Computing Linear Mathematical Models Of Aircraft

NASA Technical Reports Server (NTRS)

Duke, Eugene L.; Antoniewicz, Robert F.; Krambeer, Keith D.

1991-01-01

Derivation and Definition of Linear Aircraft Model (LINEAR) computer program provides user with powerful, and flexible, standard, documented, and verified software tool for linearization of mathematical models of aerodynamics of aircraft. Intended for use in software tool to drive linear analysis of stability and design of control laws for aircraft. Capable of both extracting such linearized engine effects as net thrust, torque, and gyroscopic effects, and including these effects in linear model of system. Designed to provide easy selection of state, control, and observation variables used in particular model. Also provides flexibility of allowing alternate formulations of both state and observation equations. Written in FORTRAN.

The SCEC Unified Community Velocity Model (UCVM) Software Framework for Distributing and Querying Seismic Velocity Models

NASA Astrophysics Data System (ADS)

Maechling, P. J.; Taborda, R.; Callaghan, S.; Shaw, J. H.; Plesch, A.; Olsen, K. B.; Jordan, T. H.; Goulet, C. A.

2017-12-01

Crustal seismic velocity models and datasets play a key role in regional three-dimensional numerical earthquake ground-motion simulation, full waveform tomography, modern physics-based probabilistic earthquake hazard analysis, as well as in other related fields including geophysics, seismology, and earthquake engineering. The standard material properties provided by a seismic velocity model are P- and S-wave velocities and density for any arbitrary point within the geographic volume for which the model is defined. Many seismic velocity models and datasets are constructed by synthesizing information from multiple sources and the resulting models are delivered to users in multiple file formats, such as text files, binary files, HDF-5 files, structured and unstructured grids, and through computer applications that allow for interactive querying of material properties. The Southern California Earthquake Center (SCEC) has developed the Unified Community Velocity Model (UCVM) software framework to facilitate the registration and distribution of existing and future seismic velocity models to the SCEC community. The UCVM software framework is designed to provide a standard query interface to multiple, alternative velocity models, even if the underlying velocity models are defined in different formats or use different geographic projections. The UCVM framework provides a comprehensive set of open-source tools for querying seismic velocity model properties, combining regional 3D models and 1D background models, visualizing 3D models, and generating computational models in the form of regular grids or unstructured meshes that can be used as inputs for ground-motion simulations. The UCVM framework helps researchers compare seismic velocity models and build equivalent simulation meshes from alternative velocity models. These capabilities enable researchers to evaluate the impact of alternative velocity models in ground-motion simulations and seismic hazard analysis applications. In this poster, we summarize the key components of the UCVM framework and describe the impact it has had in various computational geoscientific applications.

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

PubMed

Schroeder, K; Bremm, K D; Alépée, N; Bessems, J G M; Blaauboer, B; Boehn, S N; Burek, C; Coecke, S; Gombau, L; Hewitt, N J; Heylings, J; Huwyler, J; Jaeger, M; Jagelavicius, M; Jarrett, N; Ketelslegers, H; Kocina, I; Koester, J; Kreysa, J; Note, R; Poth, A; Radtke, M; Rogiers, V; Scheel, J; Schulz, T; Steinkellner, H; Toeroek, M; Whelan, M; Winkler, P; Diembeck, W

2011-04-01

There are now numerous in vitro and in silico ADME alternatives to in vivo assays but how do different industries incorporate them into their decision tree approaches for risk assessment, bearing in mind that the chemicals tested are intended for widely varying purposes? The extent of the use of animal tests is mainly driven by regulations or by the lack of a suitable in vitro model. Therefore, what considerations are needed for alternative models and how can they be improved so that they can be used as part of the risk assessment process? To address these issues, the European Partnership for Alternative Approaches to Animal Testing (EPAA) working group on prioritization, promotion and implementation of the 3Rs research held a workshop in November, 2008 in Duesseldorf, Germany. Participants included different industry sectors such as pharmaceuticals, cosmetics, industrial- and agro-chemicals. This report describes the outcome of the discussions and recommendations (a) to reduce the number of animals used for determining the ADME properties of chemicals and (b) for considerations and actions regarding in vitro and in silico assays. These included: standardisation and promotion of in vitro assays so that they may become accepted by regulators; increased availability of industry in vivo kinetic data for a central database to increase the power of in silico predictions; expansion of the applicability domains of in vitro and in silico tools (which are not necessarily more applicable or even exclusive to one particular sector) and continued collaborations between regulators, academia and industry. A recommended immediate course of action was to establish an expert panel of users, developers and regulators to define the testing scope of models for different chemical classes. It was agreed by all participants that improvement and harmonization of alternative approaches is needed for all sectors and this will most effectively be achieved by stakeholders from different sectors sharing data. Copyright © 2010 Elsevier Ltd. All rights reserved.

Preference pulses and the win-stay, fix-and-sample model of choice.

PubMed

Hachiga, Yosuke; Sakagami, Takayuki; Silberberg, Alan

2015-11-01

Two groups of six rats each were trained to respond to two levers for a food reinforcer. One group was trained on concurrent variable-ratio 20 extinction schedules of reinforcement. The second group was trained on a concurrent variable-interval 27-s extinction schedule. In both groups, lever-schedule assignments changed randomly following reinforcement; a light cued the lever providing the next reinforcer. In the next condition, the light cue was removed and reinforcer assignment strictly alternated between levers. The next two conditions redetermined, in order, the first two conditions. Preference pulses, defined as a tendency for relative response rate to decline to the just-reinforced alternative with time since reinforcement, only appeared during the extinction schedule. Although the pulse's functional form was well described by a reinforcer-induction equation, there was a large residual between actual data and a pulse-as-artifact simulation (McLean, Grace, Pitts, & Hughes, 2014) used to discern reinforcer-dependent contributions to pulsing. However, if that simulation was modified to include a win-stay tendency (a propensity to stay on the just-reinforced alternative), the residual was greatly reduced. Additional modifications of the parameter values of the pulse-as-artifact simulation enabled it to accommodate the present results as well as those it originally accommodated. In its revised form, this simulation was used to create a model that describes response runs to the preferred alternative as terminating probabilistically, and runs to the unpreferred alternative as punctate with occasional perseverative response runs. After reinforcement, choices are modeled as returning briefly to the lever location that had been just reinforced. This win-stay propensity is hypothesized as due to reinforcer induction. © Society for the Experimental Analysis of Behavior.

A Penalized Robust Method for Identifying Gene-Environment Interactions

PubMed Central

Shi, Xingjie; Liu, Jin; Huang, Jian; Zhou, Yong; Xie, Yang; Ma, Shuangge

2015-01-01

In high-throughput studies, an important objective is to identify gene-environment interactions associated with disease outcomes and phenotypes. Many commonly adopted methods assume specific parametric or semiparametric models, which may be subject to model mis-specification. In addition, they usually use significance level as the criterion for selecting important interactions. In this study, we adopt the rank-based estimation, which is much less sensitive to model specification than some of the existing methods and includes several commonly encountered data and models as special cases. Penalization is adopted for the identification of gene-environment interactions. It achieves simultaneous estimation and identification and does not rely on significance level. For computation feasibility, a smoothed rank estimation is further proposed. Simulation shows that under certain scenarios, for example with contaminated or heavy-tailed data, the proposed method can significantly outperform the existing alternatives with more accurate identification. We analyze a lung cancer prognosis study with gene expression measurements under the AFT (accelerated failure time) model. The proposed method identifies interactions different from those using the alternatives. Some of the identified genes have important implications. PMID:24616063

Prognostic alternative mRNA splicing signature in non-small cell lung cancer.

PubMed

Li, Yuan; Sun, Nan; Lu, Zhiliang; Sun, Shouguo; Huang, Jianbing; Chen, Zhaoli; He, Jie

2017-05-01

Alternative splicing provides a major mechanism to generate protein diversity. Increasing evidence suggests a link of dysregulation of splicing associated with cancer. Genome-wide alternative splicing profiling in lung cancer remains largely unstudied. We generated alternative splicing profiles in 491 lung adenocarcinoma (LUAD) and 471 lung squamous cell carcinoma (LUSC) patients in TCGA using RNA-seq data, prognostic models and splicing networks were built by integrated bioinformatics analysis. A total of 3691 and 2403 alternative splicing events were significantly associated with patient survival in LUAD and LUSC, respectively, including EGFR, CD44, PIK3C3, RRAS2, MAPKAP1 and FGFR2. The area under the curve of the receiver-operator characteristic curve for prognostic predictor in NSCLC was 0.817 at 2000 days of overall survival which were also over 0.8 in LUAD and LUSC, separately. Interestingly, splicing correlation networks uncovered opposite roles of splicing factors in LUAD and LUSC. We created prognostic predictors based on alternative splicing events with high performances for risk stratification in NSCLC patients and uncovered interesting splicing networks in LUAD and LUSC which could be underlying mechanisms. Copyright © 2017 Elsevier B.V. All rights reserved.

Alternative Gravity Rotation Curves for the LITTLE THINGS Survey

NASA Astrophysics Data System (ADS)

O’Brien, James G.; Chiarelli, Thomas L.; Dentico, Jeremy; Stulge, Modestas; Stefanski, Brian; Moss, Robert; Chaykov, Spasen

2018-01-01

Galactic rotation curves have proven to be the testing ground for dark matter bounds in spiral galaxies of all morphologies. Dwarf galaxies serve as an increasingly interesting case of rotation curve dynamics due to their typically rising rotation curve as opposed to the flattening curve of large spirals. Dwarf galaxies usually vary in galactic structure and mostly terminate at small radial distances. This, coupled with the fact that Cold Dark Matter theories struggle with the universality of galactic rotation curves, allow for exclusive features of alternative gravitational models to be analyzed. Recently, The H I Nearby Galactic Survey (THINGS) has been extended to include a sample of 25 dwarf galaxies now known as the LITTLE THINGS Survey. Here, we show an application of alternative gravitational models to the LITTLE THINGS survey, specifically focusing on conformal gravity (CG) and Modified Newtonian Dynamics (MOND). In this work, we provide an analysis and discussion of the rotation curve predictions of each theory to the sample. Furthermore, we show how these two alternative gravitational models account for the recently observed universal trends in centripetal accelerations in spiral galaxies. This work highlights the similarities and differences of the predictions of the two theories in dwarf galaxies. The sample is not large or diverse enough to strongly favor a single theory, but we posit that both CG and MOND can provide an accurate description of the galactic dynamics in the LITTLE THINGS sample without the need for dark matter.

On the effects of alternative optima in context-specific metabolic model predictions

PubMed Central

Nikoloski, Zoran

2017-01-01

The integration of experimental data into genome-scale metabolic models can greatly improve flux predictions. This is achieved by restricting predictions to a more realistic context-specific domain, like a particular cell or tissue type. Several computational approaches to integrate data have been proposed—generally obtaining context-specific (sub)models or flux distributions. However, these approaches may lead to a multitude of equally valid but potentially different models or flux distributions, due to possible alternative optima in the underlying optimization problems. Although this issue introduces ambiguity in context-specific predictions, it has not been generally recognized, especially in the case of model reconstructions. In this study, we analyze the impact of alternative optima in four state-of-the-art context-specific data integration approaches, providing both flux distributions and/or metabolic models. To this end, we present three computational methods and apply them to two particular case studies: leaf-specific predictions from the integration of gene expression data in a metabolic model of Arabidopsis thaliana, and liver-specific reconstructions derived from a human model with various experimental data sources. The application of these methods allows us to obtain the following results: (i) we sample the space of alternative flux distributions in the leaf- and the liver-specific case and quantify the ambiguity of the predictions. In addition, we show how the inclusion of ℓ1-regularization during data integration reduces the ambiguity in both cases. (ii) We generate sets of alternative leaf- and liver-specific models that are optimal to each one of the evaluated model reconstruction approaches. We demonstrate that alternative models of the same context contain a marked fraction of disparate reactions. Further, we show that a careful balance between model sparsity and metabolic functionality helps in reducing the discrepancies between alternative models. Finally, our findings indicate that alternative optima must be taken into account for rendering the context-specific metabolic model predictions less ambiguous. PMID:28557990

On the effects of alternative optima in context-specific metabolic model predictions.

PubMed

Robaina-Estévez, Semidán; Nikoloski, Zoran

2017-05-01

The integration of experimental data into genome-scale metabolic models can greatly improve flux predictions. This is achieved by restricting predictions to a more realistic context-specific domain, like a particular cell or tissue type. Several computational approaches to integrate data have been proposed-generally obtaining context-specific (sub)models or flux distributions. However, these approaches may lead to a multitude of equally valid but potentially different models or flux distributions, due to possible alternative optima in the underlying optimization problems. Although this issue introduces ambiguity in context-specific predictions, it has not been generally recognized, especially in the case of model reconstructions. In this study, we analyze the impact of alternative optima in four state-of-the-art context-specific data integration approaches, providing both flux distributions and/or metabolic models. To this end, we present three computational methods and apply them to two particular case studies: leaf-specific predictions from the integration of gene expression data in a metabolic model of Arabidopsis thaliana, and liver-specific reconstructions derived from a human model with various experimental data sources. The application of these methods allows us to obtain the following results: (i) we sample the space of alternative flux distributions in the leaf- and the liver-specific case and quantify the ambiguity of the predictions. In addition, we show how the inclusion of ℓ1-regularization during data integration reduces the ambiguity in both cases. (ii) We generate sets of alternative leaf- and liver-specific models that are optimal to each one of the evaluated model reconstruction approaches. We demonstrate that alternative models of the same context contain a marked fraction of disparate reactions. Further, we show that a careful balance between model sparsity and metabolic functionality helps in reducing the discrepancies between alternative models. Finally, our findings indicate that alternative optima must be taken into account for rendering the context-specific metabolic model predictions less ambiguous.

Effects of differential rates of alternative reinforcement on resurgence of human behavior.

PubMed

Smith, Brooke M; Smith, Gregory S; Shahan, Timothy A; Madden, Gregory J; Twohig, Michael P

2017-01-01

Despite the success of exposure-based psychotherapies in anxiety treatment, relapse remains problematic. Resurgence, the return of previously eliminated behavior following the elimination of an alternative source of reinforcement, is a promising model of operant relapse. Nonhuman resurgence research has shown that higher rates of alternative reinforcement result in faster, more comprehensive suppression of target behavior, but also in greater resurgence when alternative reinforcement is eliminated. This study investigated rich and lean rates of alternative reinforcement on response suppression and resurgence in typically developing humans. In Phase 1, three groups (Rich, n = 18; Lean, n = 18; Control, n = 10) acquired the target response. In Phase 2, target responding was extinguished and alternative reinforcement delivered on RI 1 s, RI 3 s, and extinction schedules, respectively. Resurgence was assessed during Phase 3 under extinction conditions for all groups. Target responding was suppressed most thoroughly in Rich and partially in Lean. Target responding resurged in the Rich and Lean groups, but not in the Control group. Between groups, resurgence was more pronounced in the Rich group than the Lean and Control groups. Clinical implications of these findings, including care on the part of clinicians when identifying alternative sources of reinforcement, are discussed. © 2017 Society for the Experimental Analysis of Behavior.

Impacts of Climate Change on Biofuels Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melillo, Jerry M.

2014-04-30

The overall goal of this research project was to improve and use our biogeochemistry model, TEM, to simulate the effects of climate change and other environmental changes on the production of biofuel feedstocks. We used the improved version of TEM that is coupled with the economic model, EPPA, a part of MIT’s Earth System Model, to explore how alternative uses of land, including land for biofuels production, can help society meet proposed climate targets. During the course of this project, we have made refinements to TEM that include development of a more mechanistic plant module, with improved ecohydrology and considerationmore » of plant-water relations, and a more detailed treatment of soil nitrogen dynamics, especially processes that add or remove nitrogen from ecosystems. We have documented our changes to TEM and used the model to explore the effects on production in land ecosystems, including changes in biofuels production.« less

Evaluating mechanisms of diversification in a Guineo-Congolian tropical forest frog using demographic model selection.

PubMed

Portik, Daniel M; Leaché, Adam D; Rivera, Danielle; Barej, Michael F; Burger, Marius; Hirschfeld, Mareike; Rödel, Mark-Oliver; Blackburn, David C; Fujita, Matthew K

2017-10-01

The accumulation of biodiversity in tropical forests can occur through multiple allopatric and parapatric models of diversification, including forest refugia, riverine barriers and ecological gradients. Considerable debate surrounds the major diversification process, particularly in the West African Lower Guinea forests, which contain a complex geographic arrangement of topographic features and historical refugia. We used genomic data to investigate alternative mechanisms of diversification in the Gaboon forest frog, Scotobleps gabonicus, by first identifying population structure and then performing demographic model selection and spatially explicit analyses. We found that a majority of population divergences are best explained by allopatric models consistent with the forest refugia hypothesis and involve divergence in isolation with subsequent expansion and gene flow. These population divergences occurred simultaneously and conform to predictions based on climatically stable regions inferred through ecological niche modelling. Although forest refugia played a prominent role in the intraspecific diversification of S. gabonicus, we also find evidence for potential interactions between landscape features and historical refugia, including major rivers and elevational barriers such as the Cameroonian Volcanic Line. We outline the advantages of using genomewide variation in a model-testing framework to distinguish between alternative allopatric hypotheses, and the pitfalls of limited geographic and molecular sampling. Although phylogeographic patterns are often species-specific and related to life-history traits, additional comparative studies incorporating genomic data are necessary for separating shared historical processes from idiosyncratic responses to environmental, climatic and geological influences on diversification. © 2017 John Wiley & Sons Ltd.

A 3-D Magnetic Analysis of a Stirling Convertor Linear Alternator Under Load

NASA Technical Reports Server (NTRS)

Geng, Steven M.; Schwarze, Gene E.; Niedra, Janis M.; Regan, Timothy F.

2001-01-01

The NASA Glenn Research Center (GRC), the Department of Energy (DOE), and the Stirling Technology Company (STC) are developing Stirling convertors for Stirling Radioisotope Power Systems (SRPS) to provide electrical power for future NASA deep space missions. STC is developing the 55-We Technology Demonstration Convertor (TDC) under contract to DOE. Of critical importance to the successful development of the Stirling convertor for space power applications is the development of a lightweight and highly efficient linear alternator. This paper presents a 3-dimensional finite element method (FEM) approach for evaluating Stirling convertor linear alternators. The model extends a magnetostatic analysis previously reported at the 35th Intersociety Energy Conversion Engineering Conference (IECEC) to include the effects of the load current. STC's 55-We linear alternator design was selected to validate the model. Spatial plots of magnetic field strength (H) are presented in the region of the exciting permanent magnets. The margin for permanent magnet demagnetization is calculated at the expected magnet operating temperature for the near earth environment and for various average magnet temperatures. These thermal conditions were selected to represent a worst-case condition for the planned deep space missions. This paper presents plots that identify regions of high H where the potential to alter the magnetic moment of the magnets exists.

[Factors determining the selection of treatment options of complementary and alternative medicine].

PubMed

Zörgő, Szilvia; Purebl, György; Zana, Ágnes

2016-04-10

Complementary and alternative medicine have undoubtedly been gaining ground on the healthcare market, thus the vital question arises why patients choose these treatments, oftentimes at the cost of discontinuing the Western medical therapy. The aim of the authors was to investigate and scrutinize factors leading to the utilization of various alternative medical services. The basis of this qualitative research was medical anthropological fieldwork conducted at a clinic of Traditional Chinese Medicine including participant observation (355 hours), unstructured interviews with patients (n = 93) and in-depth interviews (n = 14). Patients of alternative medical systems often do not receive a diagnosis, explanation or cure for their illness from Western medicine, or they do not agree with what they are offered. In other instances, patients choose alternative medicine because it exhibits a philosophical congruence with their already existing explanatory model, that is, previous concepts of world, man or illness. A particular therapy is always part of a cultural system and it is embedded in a specific psycho-social context, hence choice of therapy must be interpreted in accordance with this perspective.

Use of vendedores (mobile food vendors), pulgas (flea markets), and vecinos o amigos (neighbors or friends) as alternative sources of food for purchase among Mexican-origin households in Texas border colonias.

PubMed

Sharkey, Joseph R; Dean, Wesley R; Johnson, Cassandra M

2012-05-01

There is a paucity of studies acknowledging the existence of alternative food sources, and factors associated with food purchasing from three common alternative sources: vendedores (mobile food vendors), pulgas (flea markets), and vecinos/amigos (neighbors/friends). This analysis aims to examine the use of alternative food sources by Mexican-origin women from Texas-border colonias and determine factors associated with their use. The design was cross-sectional. Promotora-researchers (promotoras de salud trained in research methods) recruited 610 Mexican-origin women from 44 colonias and conducted in-person surveys. Surveys included participant characteristics and measures of food environment use and household food security. Statistical analyses included separate logistic regressions, modeled for food purchase from mobile food vendors, pulgas, or neighbors/friends. Child food insecurity was associated with purchasing food from mobile food vendors, while household food security was associated with using pulgas or neighbors/friends. School nutrition program participants were more likely to live in households that depend on alternative food sources. Efforts to increase healthful food consumption such as fruits and vegetables should acknowledge all potential food sources (traditional, convenience, nontraditional, and alternative), especially those preferred by colonia residents. Current findings support the conceptual broadening of the retail food environment, and the importance of linking use with spatial access (proximity) to more accurately depict access to food sources. Copyright © 2012 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

Alternative Fuels Data Center: Clean Cities Helps National Parks Model

Science.gov Websites

Sustainable Transportation Clean Cities Helps National Parks Model Sustainable Transportation to someone by E-mail Share Alternative Fuels Data Center: Clean Cities Helps National Parks Model Sustainable Transportation on Facebook Tweet about Alternative Fuels Data Center: Clean Cities Helps National

Approximate Bayesian estimation of extinction rate in the Finnish Daphnia magna metapopulation.

PubMed

Robinson, John D; Hall, David W; Wares, John P

2013-05-01

Approximate Bayesian computation (ABC) is useful for parameterizing complex models in population genetics. In this study, ABC was applied to simultaneously estimate parameter values for a model of metapopulation coalescence and test two alternatives to a strict metapopulation model in the well-studied network of Daphnia magna populations in Finland. The models shared four free parameters: the subpopulation genetic diversity (θS), the rate of gene flow among patches (4Nm), the founding population size (N0) and the metapopulation extinction rate (e) but differed in the distribution of extinction rates across habitat patches in the system. The three models had either a constant extinction rate in all populations (strict metapopulation), one population that was protected from local extinction (i.e. a persistent source), or habitat-specific extinction rates drawn from a distribution with specified mean and variance. Our model selection analysis favoured the model including a persistent source population over the two alternative models. Of the closest 750,000 data sets in Euclidean space, 78% were simulated under the persistent source model (estimated posterior probability = 0.769). This fraction increased to more than 85% when only the closest 150,000 data sets were considered (estimated posterior probability = 0.774). Approximate Bayesian computation was then used to estimate parameter values that might produce the observed set of summary statistics. Our analysis provided posterior distributions for e that included the point estimate obtained from previous data from the Finnish D. magna metapopulation. Our results support the use of ABC and population genetic data for testing the strict metapopulation model and parameterizing complex models of demography. © 2013 Blackwell Publishing Ltd.

Model-Based Analysis for Qualitative Data: An Application in Drosophila Germline Stem Cell Regulation

PubMed Central

Pargett, Michael; Rundell, Ann E.; Buzzard, Gregery T.; Umulis, David M.

2014-01-01

Discovery in developmental biology is often driven by intuition that relies on the integration of multiple types of data such as fluorescent images, phenotypes, and the outcomes of biochemical assays. Mathematical modeling helps elucidate the biological mechanisms at play as the networks become increasingly large and complex. However, the available data is frequently under-utilized due to incompatibility with quantitative model tuning techniques. This is the case for stem cell regulation mechanisms explored in the Drosophila germarium through fluorescent immunohistochemistry. To enable better integration of biological data with modeling in this and similar situations, we have developed a general parameter estimation process to quantitatively optimize models with qualitative data. The process employs a modified version of the Optimal Scaling method from social and behavioral sciences, and multi-objective optimization to evaluate the trade-off between fitting different datasets (e.g. wild type vs. mutant). Using only published imaging data in the germarium, we first evaluated support for a published intracellular regulatory network by considering alternative connections of the same regulatory players. Simply screening networks against wild type data identified hundreds of feasible alternatives. Of these, five parsimonious variants were found and compared by multi-objective analysis including mutant data and dynamic constraints. With these data, the current model is supported over the alternatives, but support for a biochemically observed feedback element is weak (i.e. these data do not measure the feedback effect well). When also comparing new hypothetical models, the available data do not discriminate. To begin addressing the limitations in data, we performed a model-based experiment design and provide recommendations for experiments to refine model parameters and discriminate increasingly complex hypotheses. PMID:24626201

Study on the CO2 electric driven fixed swash plate type compressor for eco-friendly vehicles

NASA Astrophysics Data System (ADS)

Nam, Donglim; Kim, Kitae; Lee, Jehie; Kwon, Yunki; Lee, Geonho

2017-08-01

The purpose of this study is to experiment and to performance analysis about the electric-driven fixed swash plate compressor using alternate refrigerant(R744). Comprehensive simulation model for an electric driven compressor using CO2 for eco-friendly vehicle is presented. This model consists of compression model and dynamic model. The compression model included valve dynamics, leakage, and heat transfer models. And the dynamic model included frictional loss between piston ring and cylinder wall, frictional loss between shoe and swash plate, frictional loss of bearings, and electric efficiency. Especially, because the efficiency of an electric parts(motor and inverter) in the compressor affects the loss of the compressor, the dynamo test was performed. We made the designed compressor, and tested the performance of the compressor about the variety pressure conditions. Also we compared the performance analysis result and performance test result.

Empirical kinetics and their role in elucidating the utility of transition-state theory to mineral–water reactions. A comment upon, ''Evidence and Potential Implications of Exponential Tails to Concentration Versus Time Plots for the Batch Dissolution of Calcite'' by V. W. Truesdale

DOE PAGES

Icenhower, Jonathan P.

2015-06-23

Transition-state theory (TST) is a successful theory for understanding many different types of reactions, but its application to mineral-water systems has not been successful, especially as the system approaches saturation with respect to a rate-limiting phase. A number of investigators have proposed alternate frameworks for using the kinetic rate data to construct models of dissolution, including Truesdale (Aquat Geochem, 2015; this issue). This alternate approach has been resisted, in spite of self-evident discrepancies between TST expectations and the data. The failure of TST under certain circumstances is a result of the presence of metastable intermediaries or reaction layers that formmore » on the surface of reacting solids, and these phenomena are not anticipated by the current theory. Furthermore, alternate approaches, such as the shrinking object model advocated by Truesdale, represent a potentially important avenue for advancing the science of dissolution kinetics.« less

Learning general phonological rules from distributional information: a computational model.

PubMed

Calamaro, Shira; Jarosz, Gaja

2015-04-01

Phonological rules create alternations in the phonetic realizations of related words. These rules must be learned by infants in order to identify the phonological inventory, the morphological structure, and the lexicon of a language. Recent work proposes a computational model for the learning of one kind of phonological alternation, allophony (Peperkamp, Le Calvez, Nadal, & Dupoux, 2006). This paper extends the model to account for learning of a broader set of phonological alternations and the formalization of these alternations as general rules. In Experiment 1, we apply the original model to new data in Dutch and demonstrate its limitations in learning nonallophonic rules. In Experiment 2, we extend the model to allow it to learn general rules for alternations that apply to a class of segments. In Experiment 3, the model is further extended to allow for generalization by context; we argue that this generalization must be constrained by linguistic principles. Copyright © 2014 Cognitive Science Society, Inc.

Urban airshed modeling of air quality impacts of alternative transportation fuel use in Los Angeles and Atlanta

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-12-01

The main objective of NREL in supporting this study is to determine the relative air quality impact of the use of compressed natural gas (CNG) as an alternative transportation fuel when compared to low Reid vapor pressure (RVP) gasoline and reformulated gasoline (RFG). A table lists the criteria, air toxic, and greenhouse gas pollutants for which emissions were estimated for the alternative fuel scenarios. Air quality impacts were then estimated by performing photochemical modeling of the alternative fuel scenarios using the Urban Airshed Model Version 6.21 and the Carbon Bond Mechanism Version IV (CBM-IV) (Geary et al., 1988) Using thismore » model, the authors examined the formation and transport of ozone under alternative fuel strategies for motor vehicle transportation sources for the year 2007. Photochemical modeling was performed for modeling domains in Los Angeles, California, and Atlanta, Georgia.« less

Fast, Statistical Model of Surface Roughness for Ion-Solid Interaction Simulations and Efficient Code Coupling

NASA Astrophysics Data System (ADS)

Drobny, Jon; Curreli, Davide; Ruzic, David; Lasa, Ane; Green, David; Canik, John; Younkin, Tim; Blondel, Sophie; Wirth, Brian

2017-10-01

Surface roughness greatly impacts material erosion, and thus plays an important role in Plasma-Surface Interactions. Developing strategies for efficiently introducing rough surfaces into ion-solid interaction codes will be an important step towards whole-device modeling of plasma devices and future fusion reactors such as ITER. Fractal TRIDYN (F-TRIDYN) is an upgraded version of the Monte Carlo, BCA program TRIDYN developed for this purpose that includes an explicit fractal model of surface roughness and extended input and output options for file-based code coupling. Code coupling with both plasma and material codes has been achieved and allows for multi-scale, whole-device modeling of plasma experiments. These code coupling results will be presented. F-TRIDYN has been further upgraded with an alternative, statistical model of surface roughness. The statistical model is significantly faster than and compares favorably to the fractal model. Additionally, the statistical model compares well to alternative computational surface roughness models and experiments. Theoretical links between the fractal and statistical models are made, and further connections to experimental measurements of surface roughness are explored. This work was supported by the PSI-SciDAC Project funded by the U.S. Department of Energy through contract DOE-DE-SC0008658.

Greenhouse gas emissions from alternative water supply processes in southern California, USA

NASA Astrophysics Data System (ADS)

Schneider, A.; Townsend-Small, A.

2012-12-01

Burgeoning population centers and declining hydrological resources have encouraged the development of alternative water treatment systems, including desalination and wastewater recycling. These processes currently provide potable water for millions of people and assist in satisfying agricultural and landscaping irrigation demands. There are a variety of alternative water production methods in place, and while they help to reduce the demands placed on aquifers, during their operation they are also significant sources of greenhouse gases. The environmental advantages of these alternative water production methods need to be carefully weighed against their energy footprints and greenhouse gas emissions profiles. This study measured the greenhouse gas emissions of a wastewater treatment and recycling facility in Orange County, California to get a more complete picture of the carbon footprint of the plant. We measured atmospheric emissions of CO2, CH4, and N2O throughout the water recycling process and at various times of the day and week. This allowed us to assemble a thorough, cross-sectional profile of greenhouse gas emissions from the facility. We then compared the measured emissions of the treatment plant to the modeled emissions of desalination plants in order to assess the relative carbon footprints of the two water production methods. Other water supply alternatives, including regional water importation, were also included in the comparison in order to provide a more complete understanding of the potential greenhouse gas emissions. Finally, we assessed the significance of wastewater treatment as an urban greenhouse gas source when compared to other known emissions in the region. This research offers a valuable tool for sustainable urban and regional development by providing planners with a quantified comparison of the carbon footprints of several water production options.

Electric Drive Dynamic Thermal System Model for Advanced Vehicle Propulsion Technologies: Cooperative Research and Development Final Report, CRADA Number CRD-09-360

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennion, K.

Electric drive systems, which include electric machines and power electronics, are a key enabling technology for advanced vehicle propulsion systems that reduce the dependence of the U.S. transportation sector on petroleum. However, to penetrate the market, these electric drive technologies must enable vehicle solutions that are economically viable. The push to make critical electric drivesystems smaller, lighter, and more cost-effective brings respective challenges associated with heat removal and system efficiency. In addition, the wide application of electric drive systems to alternative propulsion technologies ranging from integrated starter generators, to hybrid electric vehicles, to full electric vehicles presents challenges in termsmore » of sizing critical components andthermal management systems over a range of in-use operating conditions. This effort focused on developing a modular modeling methodology to enable multi-scale and multi-physics simulation capabilities leading to generic electric drive system models applicable to alternative vehicle propulsion configurations. The primary benefit for the National Renewable Energy Laboratory (NREL) is the abilityto define operating losses with the respective impact on component sizing, temperature, and thermal management at the component, subsystem, and system level. However, the flexible nature of the model also allows other uses related to evaluating the impacts of alternative component designs or control schemes depending on the interests of other parties.« less

The value of information for woodland management: Updating a state–transition model

USGS Publications Warehouse

Morris, William K.; Runge, Michael C.; Vesk, Peter A.

2017-01-01

Value of information (VOI) analyses reveal the expected benefit of reducing uncertainty to a decision maker. Most ecological VOI analyses have focused on population models rarely addressing more complex community models. We performed a VOI analysis for a complex state–transition model of Box-Ironbark Forest and Woodland management. With three management alternatives (limited harvest/firewood removal (HF), ecological thinning (ET), and no management), managing the system optimally (for 150 yr) with the original information would, on average, increase the amount of forest in a desirable state from 19% to 35% (a 16-percentage point increase). Resolving all uncertainty would, on average, increase the final percentage to 42% (a 19-percentage point increase). However, only resolving the uncertainty for a single parameter was worth almost two-thirds the value of resolving all uncertainty. We found the VOI to depend on the number of management options, increasing as the management flexibility increased. Our analyses show it is more cost-effective to monitor low-density regrowth forest than other states and more cost-effective to experiment with the no-management alternative than the other management alternatives. Importantly, the most cost-effective strategies did not include either the most desired forest states or the least understood management strategy, ET. This implies that managers cannot just rely on intuition to tell them where the most VOI will lie, as critical uncertainties in a complex system are sometimes cryptic.

The logic of the floral transition: Reverse-engineering the switch controlling the identity of lateral organs.

PubMed

Dinh, Jean-Louis; Farcot, Etienne; Hodgman, Charlie

2017-09-01

Much laboratory work has been carried out to determine the gene regulatory network (GRN) that results in plant cells becoming flowers instead of leaves. However, this also involves the spatial distribution of different cell types, and poses the question of whether alternative networks could produce the same set of observed results. This issue has been addressed here through a survey of the published intercellular distribution of expressed regulatory genes and techniques both developed and applied to Boolean network models. This has uncovered a large number of models which are compatible with the currently available data. An exhaustive exploration had some success but proved to be unfeasible due to the massive number of alternative models, so genetic programming algorithms have also been employed. This approach allows exploration on the basis of both data-fitting criteria and parsimony of the regulatory processes, ruling out biologically unrealistic mechanisms. One of the conclusions is that, despite the multiplicity of acceptable models, an overall structure dominates, with differences mostly in alternative fine-grained regulatory interactions. The overall structure confirms the known interactions, including some that were not present in the training set, showing that current data are sufficient to determine the overall structure of the GRN. The model stresses the importance of relative spatial location, through explicit references to this aspect. This approach also provides a quantitative indication of how likely some regulatory interactions might be, and can be applied to the study of other developmental transitions.

Performance of new alternative providers of primary care services in England: an observational study

PubMed Central

Greaves, Felix; Laverty, Anthony A; Pape, Utz; Ratneswaren, Anenta; Majeed, Azeem

2015-01-01

Summary Objectives Health system reforms in England are opening broad areas of clinical practice to new providers of care. As part of these reforms, new entrants – including private companies – have been allowed into the primary care market under ‘alternative provider of medical services’ contracting mechanisms since 2004. The characteristics and performance of general practices working under new alternative provider contracts are not well described. We sought to compare the quality of care provided by new entrant providers to that provided by the traditional model of general practice. Design Open cohort study of English general practices. We used linear regression in cross-sectional and time series analyses, adjusting for practice and population characteristics, to compare quality in practices using alternative provider contracts to traditional practices. We created regression models using practice fixed effects to estimate the impact of practices changing to the new contract type. Setting The English National Health Service. Participants All general practices open from 2008/2009 to 2012/2013. Main outcome measures Seventeen established quality indicators – covering clinical effectiveness, efficiency, access and patient experience. Results In total, 4.1% (347 of 8300) of general practices in England were run by alternative contract providers. These practices tended to be smaller, and serve younger, more diverse and more deprived populations than traditional providers. Practices run by alternative providers performed worse than traditional providers on 15 of 17 indicators after adjusting for practice and population characteristics (p < 0.01 for all). Switching to a new alternative provider contract did not result in improved performance. Conclusions The introduction of new alternative providers to deliver primary care services in England has not led to improvements in quality and may have resulted in worse care. Regulators should ensure that new entrants to clinical provider markets are performing to adequate standards and at least as well as traditional providers. PMID:25908312

Performance of new alternative providers of primary care services in England: an observational study.

PubMed

Greaves, Felix; Laverty, Anthony A; Pape, Utz; Ratneswaren, Anenta; Majeed, Azeem; Millett, Christopher

2015-05-01

Health system reforms in England are opening broad areas of clinical practice to new providers of care. As part of these reforms, new entrants--including private companies--have been allowed into the primary care market under 'alternative provider of medical services' contracting mechanisms since 2004. The characteristics and performance of general practices working under new alternative provider contracts are not well described. We sought to compare the quality of care provided by new entrant providers to that provided by the traditional model of general practice. Open cohort study of English general practices. We used linear regression in cross-sectional and time series analyses, adjusting for practice and population characteristics, to compare quality in practices using alternative provider contracts to traditional practices. We created regression models using practice fixed effects to estimate the impact of practices changing to the new contract type. The English National Health Service. All general practices open from 2008/2009 to 2012/2013. Seventeen established quality indicators--covering clinical effectiveness, efficiency, access and patient experience. In total, 4.1% (347 of 8300) of general practices in England were run by alternative contract providers. These practices tended to be smaller, and serve younger, more diverse and more deprived populations than traditional providers. Practices run by alternative providers performed worse than traditional providers on 15 of 17 indicators after adjusting for practice and population characteristics (p < 0.01 for all). Switching to a new alternative provider contract did not result in improved performance. The introduction of new alternative providers to deliver primary care services in England has not led to improvements in quality and may have resulted in worse care. Regulators should ensure that new entrants to clinical provider markets are performing to adequate standards and at least as well as traditional providers. © The Royal Society of Medicine.

Multi objective decision making in hybrid energy system design

NASA Astrophysics Data System (ADS)

Merino, Gabriel Guillermo

The design of grid-connected photovoltaic wind generator system supplying a farmstead in Nebraska has been undertaken in this dissertation. The design process took into account competing criteria that motivate the use of different sources of energy for electric generation. The criteria considered were 'Financial', 'Environmental', and 'User/System compatibility'. A distance based multi-objective decision making methodology was developed to rank design alternatives. The method is based upon a precedence order imposed upon the design objectives and a distance metric describing the performance of each alternative. This methodology advances previous work by combining ambiguous information about the alternatives with a decision-maker imposed precedence order in the objectives. Design alternatives, defined by the photovoltaic array and wind generator installed capacities, were analyzed using the multi-objective decision making approach. The performance of the design alternatives was determined by simulating the system using hourly data for an electric load for a farmstead and hourly averages of solar irradiation, temperature and wind speed from eight wind-solar energy monitoring sites in Nebraska. The spatial variability of the solar energy resource within the region was assessed by determining semivariogram models to krige hourly and daily solar radiation data. No significant difference was found in the predicted performance of the system when using kriged solar radiation data, with the models generated vs. using actual data. The spatial variability of the combined wind and solar energy resources was included in the design analysis by using fuzzy numbers and arithmetic. The best alternative was dependent upon the precedence order assumed for the main criteria. Alternatives with no PV array or wind generator dominated when the 'Financial' criteria preceded the others. In contrast, alternatives with a nil component of PV array but a high wind generator component, dominated when the 'Environment' objective or the 'User/System compatibility' objectives were more important than the 'Financial' objectives and they also dominated when the three criteria were considered equally important.

Stirling System Modeling for Space Nuclear Power Systems

NASA Technical Reports Server (NTRS)

Lewandowski, Edward J.; Johnson, Paul K.

2008-01-01

A dynamic model of a high-power Stirling convertor has been developed for space nuclear power systems modeling. The model is based on the Component Test Power Convertor (CTPC), a 12.5-kWe free-piston Stirling convertor. The model includes the fluid heat source, the Stirling convertor, output power, and heat rejection. The Stirling convertor model includes the Stirling cycle thermodynamics, heat flow, mechanical mass-spring damper systems, and the linear alternator. The model was validated against test data. Both nonlinear and linear versions of the model were developed. The linear version algebraically couples two separate linear dynamic models; one model of the Stirling cycle and one model of the thermal system, through the pressure factors. Future possible uses of the Stirling system dynamic model are discussed. A pair of commercially available 1-kWe Stirling convertors is being purchased by NASA Glenn Research Center. The specifications of those convertors may eventually be incorporated into the dynamic model and analysis compared to the convertor test data. Subsequent potential testing could include integrating the convertors into a pumped liquid metal hot-end interface. This test would provide more data for comparison to the dynamic model analysis.

41 CFR 102-80.120 - What analytical and empirical tools should be used to support the life safety equivalency...

Code of Federal Regulations, 2014 CFR

2014-01-01

...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 80-SAFETY AND ENVIRONMENTAL MANAGEMENT Accident and Fire... used to support the life safety equivalency evaluation? Analytical and empirical tools, including fire models and grading schedules such as the Fire Safety Evaluation System (Alternative Approaches to Life...

41 CFR 102-80.120 - What analytical and empirical tools should be used to support the life safety equivalency...

Code of Federal Regulations, 2013 CFR

2013-07-01

...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 80-SAFETY AND ENVIRONMENTAL MANAGEMENT Accident and Fire... used to support the life safety equivalency evaluation? Analytical and empirical tools, including fire models and grading schedules such as the Fire Safety Evaluation System (Alternative Approaches to Life...

41 CFR 102-80.120 - What analytical and empirical tools should be used to support the life safety equivalency...

Code of Federal Regulations, 2012 CFR

2012-01-01

...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 80-SAFETY AND ENVIRONMENTAL MANAGEMENT Accident and Fire... used to support the life safety equivalency evaluation? Analytical and empirical tools, including fire models and grading schedules such as the Fire Safety Evaluation System (Alternative Approaches to Life...

"Why Fly That Way?" Linking Community and Academic Achievement.

ERIC Educational Resources Information Center

Greely, Kathy

This book tells the story of a year in one middle school teacher's class full of lively young adolescents, highlighting exemplary ways of learning and types of schooling. This alternative model of education shows how a strong, supportive community is essential in helping students reach their highest potential. The book includes: specific projects…

42 CFR 81.24 - Guidelines for leukemia.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Guidelines for leukemia. 81.24 Section 81.24 Public... Causation § 81.24 Guidelines for leukemia. (a) For claims involving leukemia, DOL will calculate one or more probability of causation estimates from up to three of the four alternate leukemia risk models included in...

Models for Integrated Education: Alternative Programs of Integrated Education in Metropolitan Areas. Contemporary Education Issues Series.

ERIC Educational Resources Information Center

Levine, Daniel U., Ed.

Contents of this book include: (1) "Introduction: race and educational opportunity," Meyer Weinberg; (2) "Project 'Unique' and efforts to eliminate racial imbalance in Rochester, New York," Herman R. Goldberg and Raymond S. Iman; (3) "Project 'Apex': magnet schools for enrichment and exchange in Los Angeles," Albert…

42 CFR 81.24 - Guidelines for leukemia.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Guidelines for leukemia. 81.24 Section 81.24 Public... Causation § 81.24 Guidelines for leukemia. (a) For claims involving leukemia, DOL will calculate one or more probability of causation estimates from up to three of the four alternate leukemia risk models included in...

Documenting Student Learning in Music Performance: A Framework

ERIC Educational Resources Information Center

Wesolowski, Brian

2014-01-01

A fundamental aim of the Race to the Top agenda is to assess the effectiveness of teachers based on value-added growth measurement models of student achievement. However, in nontested grades and subject areas, such as music, alternative assessment types are being considered, including district-, school-, or teacher-developed measures. This article…

42 CFR 81.24 - Guidelines for leukemia.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Guidelines for leukemia. 81.24 Section 81.24 Public... Causation § 81.24 Guidelines for leukemia. (a) For claims involving leukemia, DOL will calculate one or more probability of causation estimates from up to three of the four alternate leukemia risk models included in...

42 CFR 81.24 - Guidelines for leukemia.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Guidelines for leukemia. 81.24 Section 81.24 Public... Causation § 81.24 Guidelines for leukemia. (a) For claims involving leukemia, DOL will calculate one or more probability of causation estimates from up to three of the four alternate leukemia risk models included in...

42 CFR 81.24 - Guidelines for leukemia.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Guidelines for leukemia. 81.24 Section 81.24 Public... Causation § 81.24 Guidelines for leukemia. (a) For claims involving leukemia, DOL will calculate one or more probability of causation estimates from up to three of the four alternate leukemia risk models included in...

Energy requirement for the production of silicon solar arrays

NASA Technical Reports Server (NTRS)

Lindmayer, J.; Wihl, M.; Scheinine, A.; Morrison, A.

1977-01-01

An assessment of potential changes and alternative technologies which could impact the photovoltaic manufacturing process is presented. Topics discussed include: a multiple wire saw, ribbon growth techniques, silicon casting, and a computer model for a large-scale solar power plant. Emphasis is placed on reducing the energy demands of the manufacturing process.

Assessment of Alternative Student Aid Delivery Systems: Assessment of the Current Delivery System.

ERIC Educational Resources Information Center

Advanced Technology, Inc., Reston, VA.

The effects of the current system for delivering federal financial assistance to students under the Pell Grant, Guaranteed Student Loan (GSL), and campus-based programs are analyzed. Information is included on the use of the assessment model, which combines program evaluation, systems research, and policy analysis methodologies.…

A Market-oriented Approach To Maximizing Product Benefits: Cases in U.S. Forest Products Industries

Treesearch

Vijay S. Reddy; Robert J. Bush; Ronen Roudik

1996-01-01

Conjoint analysis, a decompositional customer preference modelling technique, has seen little application to forest products. However, the technique provides useful information for marketing decisions by quantifying consumer preference functions for multiattribute product alternatives. The results of a conjoint analysis include the contribution of each attribute and...

US EPA - A*Star Partnership - Accelerating the Acceptance of Next-Generation Sciences and Their Application to Regulatory Risk Assessment (A*Star Symposium, Singapore)

EPA Science Inventory

The path for incorporating new alternative methods and technologies into quantitative chemical risk assessment poses a diverse set of scientific challenges. Some of these challenges include development of relevant and predictive test systems and computational models to integrate...

Report Card on Enrollment Projections and Other Selected Papers. Third Annual Meeting of the North Carolina Association for Institutional Research.

ERIC Educational Resources Information Center

Brown, Charles I., Ed.

The major theme of Report Card 1 is enrollment projections. Reports in this section include: Barwick and Stafford's "Statewide Enrollment Projections for North Carolina, 1975-80"; Reiman's "Assumption-Based Model for Developing Institutional Enrollment Projections"; Rajasekhara's "Enrollment Projection," dealing with alternative methods;…

Speededness and Adaptive Testing

ERIC Educational Resources Information Center

van der Linden, Wim J.; Xiong, Xinhui

2013-01-01

Two simple constraints on the item parameters in a response--time model are proposed to control the speededness of an adaptive test. As the constraints are additive, they can easily be included in the constraint set for a shadow-test approach (STA) to adaptive testing. Alternatively, a simple heuristic is presented to control speededness in plain…

The Wilderness Therapy Prevention Program: A Prevention Model for At-Risk Children and Adolescents

ERIC Educational Resources Information Center

Butler, Meghan

2008-01-01

Wilderness Therapy Programs have recently become a formal alternative treatment for adolescents with emotional and behavioral disorders (Hinkle, 1999; Russell & Hendee, 1999; Russell, Hendee, & Phillips-Miller, 2000; Russell, 2003a, 2003b). Adolescent populations are unique in that traditional forms of psychotherapy, including "talk-therapies,"…

Symbiosis-Based Alternative Learning Multi-Swarm Particle Swarm Optimization.

PubMed

Niu, Ben; Huang, Huali; Tan, Lijing; Duan, Qiqi

2017-01-01

Inspired by the ideas from the mutual cooperation of symbiosis in natural ecosystem, this paper proposes a new variant of PSO, named Symbiosis-based Alternative Learning Multi-swarm Particle Swarm Optimization (SALMPSO). A learning probability to select one exemplar out of the center positions, the local best position, and the historical best position including the experience of internal and external multiple swarms, is used to keep the diversity of the population. Two different levels of social interaction within and between multiple swarms are proposed. In the search process, particles not only exchange social experience with others that are from their own sub-swarms, but also are influenced by the experience of particles from other fellow sub-swarms. According to the different exemplars and learning strategy, this model is instantiated as four variants of SALMPSO and a set of 15 test functions are conducted to compare with some variants of PSO including 10, 30 and 50 dimensions, respectively. Experimental results demonstrate that the alternative learning strategy in each SALMPSO version can exhibit better performance in terms of the convergence speed and optimal values on most multimodal functions in our simulation.

Alternative Models of Service, Centralized Machine Operations. Phase II Report. Volume II.

ERIC Educational Resources Information Center

Technology Management Corp., Alexandria, VA.

A study was conducted to determine if the centralization of playback machine operations for the national free library program would be feasible, economical, and desirable. An alternative model of playback machine services was constructed and compared with existing network operations considering both cost and service. The alternative model was…

Mountaintop island age determines species richness of boreal mammals in the American Southwest

USGS Publications Warehouse

Frey, J.K.; Bogan, M.A.; Yates, Terry L.

2007-01-01

Models that describe the mechanisms responsible for insular patterns of species richness include the equilibrium theory of island biogeography and the nonequilibrium vicariance model. The relative importance of dispersal or vicariance in structuring insular distribution patterns can be inferred from these models. Predictions of the alternative models were tested for boreal mammals in the American Southwest. Age of mountaintop islands of boreal habitat was determined by constructing a geographic cladogram based on characteristics of intervening valley barriers. Other independent variables included area and isolation of mountaintop islands. Island age was the most important predictor of species richness. In contrast with previous studies of species richness patterns in this system, these results supported the nonequilibrium vicariance model, which indicates that vicariance has been the primary determinant of species distribution patterns in this system.

Estimation of Model's Marginal likelihood Using Adaptive Sparse Grid Surrogates in Bayesian Model Averaging

NASA Astrophysics Data System (ADS)

Zeng, X.

2015-12-01

A large number of model executions are required to obtain alternative conceptual models' predictions and their posterior probabilities in Bayesian model averaging (BMA). The posterior model probability is estimated through models' marginal likelihood and prior probability. The heavy computation burden hinders the implementation of BMA prediction, especially for the elaborated marginal likelihood estimator. For overcoming the computation burden of BMA, an adaptive sparse grid (SG) stochastic collocation method is used to build surrogates for alternative conceptual models through the numerical experiment of a synthetical groundwater model. BMA predictions depend on model posterior weights (or marginal likelihoods), and this study also evaluated four marginal likelihood estimators, including arithmetic mean estimator (AME), harmonic mean estimator (HME), stabilized harmonic mean estimator (SHME), and thermodynamic integration estimator (TIE). The results demonstrate that TIE is accurate in estimating conceptual models' marginal likelihoods. The BMA-TIE has better predictive performance than other BMA predictions. TIE has high stability for estimating conceptual model's marginal likelihood. The repeated estimated conceptual model's marginal likelihoods by TIE have significant less variability than that estimated by other estimators. In addition, the SG surrogates are efficient to facilitate BMA predictions, especially for BMA-TIE. The number of model executions needed for building surrogates is 4.13%, 6.89%, 3.44%, and 0.43% of the required model executions of BMA-AME, BMA-HME, BMA-SHME, and BMA-TIE, respectively.

Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.

PubMed

Melis, Joost P M; Speksnijder, Ewoud N; Kuiper, Raoul V; Salvatori, Daniela C F; Schaap, Mirjam M; Maas, Saskia; Robinson, Joke; Verhoef, Aart; van Benthem, Jan; Luijten, Mirjam; van Steeg, Harry

2013-01-15

An accurate assessment of the carcinogenic potential of chemicals and pharmaceutical drugs is essential to protect humans and the environment. Therefore, substances are extensively tested before they are marketed to the public. Currently, the rodent two-year bioassay is still routinely used to assess the carcinogenic potential of substances. However, over time it has become clear that this assay yields false positive results and also has several economic and ethical drawbacks including the use of large numbers of animals, the long duration, and the high cost. The need for a suitable alternative assay is therefore high. Previously, we have proposed the Xpa*p53 mouse model as a very suitable alternative to the two-year bioassay. We now show that the Xpc*p53 mouse model preserves all the beneficial traits of the Xpa*p53 model for sub-chronic carcinogen identification and can identify both genotoxic and non-genotoxic carcinogens. Moreover, Xpc*p53 mice appear to be more responsive than Xpa*p53 mice towards several genotoxic and non-genotoxic carcinogens. Furthermore, Xpc*p53 mice are far less sensitive than Xpa*p53 mice for the toxic activity of DNA damaging agents and as such clearly respond in a similar way as wild type mice do. These advantageous traits of the Xpc*p53 model make it a better alternative for in vivo carcinogen testing than Xpa*p53. This pilot study suggests that Xpc*p53 mice are suited for routine sub-chronic testing of both genotoxic and non-genotoxic carcinogens and as such represent a suitable alternative to possibly replace the murine life time cancer bioassay. Copyright © 2012 Elsevier Inc. All rights reserved.

Qualitative models for space system engineering

NASA Technical Reports Server (NTRS)

Forbus, Kenneth D.

1990-01-01

The objectives of this project were: (1) to investigate the implications of qualitative modeling techniques for problems arising in the monitoring, diagnosis, and design of Space Station subsystems and procedures; (2) to identify the issues involved in using qualitative models to enhance and automate engineering functions. These issues include representing operational criteria, fault models, alternate ontologies, and modeling continuous signals at a functional level of description; and (3) to develop a prototype collection of qualitative models for fluid and thermal systems commonly found in Space Station subsystems. Potential applications of qualitative modeling to space-systems engineering, including the notion of intelligent computer-aided engineering are summarized. Emphasis is given to determining which systems of the proposed Space Station provide the most leverage for study, given the current state of the art. Progress on using qualitative models, including development of the molecular collection ontology for reasoning about fluids, the interaction of qualitative and quantitative knowledge in analyzing thermodynamic cycles, and an experiment on building a natural language interface to qualitative reasoning is reported. Finally, some recommendations are made for future research.

Effect of Additional Incentives for Aviation Biofuels: Results from the Biomass Scenario Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vimmerstedt, Laura J; Newes, Emily K

2017-12-05

The National Renewable Energy Laboratory supported the Department of Energy, Bioenergy Technologies Office, with analysis of alternative jet fuels in collaboration with the U.S. Department of Transportation, Federal Aviation Administration. Airlines for America requested additional exploratory scenarios within FAA analytic framework. Airlines for America requested additional analysis using the same analytic framework, the Biomass Scenario Model. The results were presented at a public working meeting of the California Air Resources Board on including alternative jet fuel in the Low Carbon Fuel Standard on March 17, 2017 (https://www.arb.ca.gov/fuels/lcfs/lcfs_meetings/lcfs_meetings.htm). This presentation clarifies and annotates the slides from the public working meeting, andmore » provides a link to the full data set. NREL does not advocate for or against the policies analyzed in this study.« less

Cost of Ownership and Well-to-Wheels Carbon Emissions/Oil Use of Alternative Fuels and Advanced Light-Duty Vehicle Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elgowainy, Mr. Amgad; Rousseau, Mr. Aymeric; Wang, Mr. Michael

2013-01-01

The U.S. Department of Energy (DOE), Argonne National Laboratory (Argonne), and the National Renewable Energy Laboratory (NREL) updated their analysis of the well-to-wheels (WTW) greenhouse gases (GHG) emissions, petroleum use, and the cost of ownership (excluding insurance, maintenance, and miscellaneous fees) of vehicle technologies that have the potential to significantly reduce GHG emissions and petroleum consumption. The analyses focused on advanced light-duty vehicle (LDV) technologies such as plug-in hybrid, battery electric, and fuel cell electric vehicles. Besides gasoline and diesel, alternative fuels considered include natural gas, advanced biofuels, electricity, and hydrogen. The Argonne Greenhouse Gases, Regulated Emissions, and Energy Usemore » in Transportation (GREET) and Autonomie models were used along with the Argonne and NREL H2A models.« less

Effect of Additional Incentives for Aviation Biofuels: Results from the Biomass Scenario Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vimmerstedt, Laura J; Newes, Emily K

The National Renewable Energy Laboratory supported the Department of Energy, Bioenergy Technologies Office, with analysis of alternative jet fuels in collaboration with the U.S. Department of Transportation, Federal Aviation Administration. Airlines for America requested additional exploratory scenarios within FAA analytic framework. Airlines for America requested additional analysis using the same analytic framework, the Biomass Scenario Model. The results were presented at a public working meeting of the California Air Resources Board on including alternative jet fuel in the Low Carbon Fuel Standard on March 17, 2017 (https://www.arb.ca.gov/fuels/lcfs/lcfs_meetings/lcfs_meetings.htm). This presentation clarifies and annotates the slides from the public working meeting, andmore » provides a link to the full data set. NREL does not advocate for or against the policies analyzed in this study.« less

Neutron Star Models in Alternative Theories of Gravity

NASA Astrophysics Data System (ADS)

Manolidis, Dimitrios

We study the structure of neutron stars in a broad class of alternative theories of gravity. In particular, we focus on Scalar-Tensor theories and f(R) theories of gravity. We construct static and slowly rotating numerical star models for a set of equations of state, including a polytropic model and more realistic equations of state motivated by nuclear physics. Observable quantities such as masses, radii, etc are calculated for a set of parameters of the theories. Specifically for Scalar-Tensor theories, we also calculate the sensitivities of the mass and moment of inertia of the models to variations in the asymptotic value of the scalar field at infinity. These quantities enter post-Newtonian equations of motion and gravitational waveforms of two body systems that are used for gravitational-wave parameter estimation, in order to test these theories against observations. The construction of numerical models of neutron stars in f(R) theories of gravity has been difficult in the past. Using a new formalism by Jaime, Patino and Salgado we were able to construct models with high interior pressure, namely pc > rho c/3, both for constant density models and models with a polytropic equation of state. Thus, we have shown that earlier objections to f(R) theories on the basis of the inability to construct viable neutron star models are unfounded.

Are central institutional review boards the solution? The National Heart, Lung, and Blood Institute Working Group's report on optimizing the IRB process.

PubMed

Mascette, Alice M; Bernard, Gordon R; Dimichele, Donna; Goldner, Jesse A; Harrington, Robert; Harris, Paul A; Leeds, Hilary S; Pearson, Thomas A; Ramsey, Bonnie; Wagner, Todd H

2012-12-01

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened a working group in June 2011 to examine alternative institutional review board (IRB) models. The working group was held in response to proposed changes in the regulations for government-supported research and the proliferation of multicenter clinical trials where multiple individual reviews may be inefficient. Group members included experts in heart, lung, and blood research, research oversight, bioethics, health economics, regulations, and information technology (IT). The group discussed alternative IRB models, ethical concerns, metrics for evaluating IRBs, IT needs, and economic considerations. Participants noted research gaps in IRB best practices and in metrics. The group arrived at recommendations for process changes, such as defining specific IRB performance requirements in funding announcements, requiring funded researchers to use more efficient alternative IRB models, and developing IT systems to facilitate information sharing and collaboration among IRBs. Despite the success of the National Cancer Institute's central IRB (CIRB), the working group, concerned about the creation costs and unknown cost-efficiency of a new CIRB, and about the risk of shifting the burden of dealing with multiple IRBs from sponsors to research institutions, did not recommend the creation of an NHLBI-funded CIRB.

The role of reservoir storage in large-scale surface water availability analysis for Europe

NASA Astrophysics Data System (ADS)

Garrote, L. M.; Granados, A.; Martin-Carrasco, F.; Iglesias, A.

2017-12-01

A regional assessment of current and future water availability in Europe is presented in this study. The assessment was made using the Water Availability and Adaptation Policy Analysis (WAAPA) model. The model was built on the river network derived from the Hydro1K digital elevation maps, including all major river basins of Europe. Reservoir storage volume was taken from the World Register of Dams of ICOLD, including all dams with storage capacity over 5 hm3. Potential Water Availability is defined as the maximum amount of water that could be supplied at a certain point of the river network to satisfy a regular demand under pre-specified reliability requirements. Water availability is the combined result of hydrological processes, which determine streamflow in natural conditions, and human intervention, which determines the available hydraulic infrastructure to manage water and establishes water supply conditions through operating rules. The WAAPA algorithm estimates the maximum demand that can be supplied at every node of the river network accounting for the regulation capacity of reservoirs under different management scenarios. The model was run for a set of hydrologic scenarios taken from the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP), where the PCRGLOBWB hydrological model was forced with results from five global climate models. Model results allow the estimation of potential water stress by comparing water availability to projections of water abstractions along the river network under different management alternatives. The set of sensitivity analyses performed showed the effect of policy alternatives on water availability and highlighted the large uncertainties linked to hydrological and anthropological processes.

Time series regression model for infectious disease and weather.

PubMed

Imai, Chisato; Armstrong, Ben; Chalabi, Zaid; Mangtani, Punam; Hashizume, Masahiro

2015-10-01

Time series regression has been developed and long used to evaluate the short-term associations of air pollution and weather with mortality or morbidity of non-infectious diseases. The application of the regression approaches from this tradition to infectious diseases, however, is less well explored and raises some new issues. We discuss and present potential solutions for five issues often arising in such analyses: changes in immune population, strong autocorrelations, a wide range of plausible lag structures and association patterns, seasonality adjustments, and large overdispersion. The potential approaches are illustrated with datasets of cholera cases and rainfall from Bangladesh and influenza and temperature in Tokyo. Though this article focuses on the application of the traditional time series regression to infectious diseases and weather factors, we also briefly introduce alternative approaches, including mathematical modeling, wavelet analysis, and autoregressive integrated moving average (ARIMA) models. Modifications proposed to standard time series regression practice include using sums of past cases as proxies for the immune population, and using the logarithm of lagged disease counts to control autocorrelation due to true contagion, both of which are motivated from "susceptible-infectious-recovered" (SIR) models. The complexity of lag structures and association patterns can often be informed by biological mechanisms and explored by using distributed lag non-linear models. For overdispersed models, alternative distribution models such as quasi-Poisson and negative binomial should be considered. Time series regression can be used to investigate dependence of infectious diseases on weather, but may need modifying to allow for features specific to this context. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Factors related to complementary/alternative medicine use among cancer patients in central Anatolia.

PubMed

Er, Ozlem; Mistik, Selcuk; Ozkan, Metin; Ozturk, Ahmet; Altinbas, Mustafa

2008-01-01

We aimed to evaluate the prevalence of and factors related to the use of complementary/alternative medicine among cancer patients undergoing or following conventional treatment at the Erciyes University Oncology Hospital in Central Anatolia. Face-to-face interview and a questionnaire were carried out with cancer patients attending the outpatient clinic of Medical Oncology. Questionnaire items included patients' demographic data, treatment, use of complementary/alternative medicine and possible related factors. Multivariate analysis was performed to compare the factors related to use of complementary/alternative medicine. A total of 268 consecutive cancer patients were enrolled in the study. Overall, 43% of the patients were using or had used complementary/alternative medicine. Totally, 90% of the patients using complementary/alternative medicine utilized herbs, and most of the herbs used were stinging nettle. Nearly half of the patients using complementary/alternative medicine (46.1%) were aiming to fight the disease. Among users, nearly half of them regarded the method used as effective and 54 (50.5%) suggested the use of complementary/alternative medicine to other patients. Only 23.1% of the patients discussed the use of complementary/alternative medicine with their physician. In logistic regression analysis, younger age, higher educational status, advanced stage of the disease, longer duration of the disease and current treatment status were significantly associated with the use of complementary/alternative medicine. In our regression model, the predictivity rate of these variables was 72.2% for use of complementary/alternative medicine according to the backward Wald test. Use of complementary/alternative medicine among cancer patients in our center is modestly high, and the most common method is herbal therapy. Communication between the patient and the physician should be improved on this subject.

Land-use planning for nearshore ecosystem services—the Puget Sound Ecosystem Portfolio Model

USGS Publications Warehouse

Byrd, Kristin

2011-01-01

The 2,500 miles of shoreline and nearshore areas of Puget Sound, Washington, provide multiple benefits to people—"ecosystem services"—including important fishing, shellfishing, and recreation industries. To help resource managers plan for expected growth in coming decades, the U.S. Geological Survey Western Geographic Science Center has developed the Puget Sound Ecosystem Portfolio Model (PSEPM). Scenarios of urban growth and shoreline modifications serve as model inputs to develop alternative futures of important nearshore features such as water quality and beach habitats. Model results will support regional long-term planning decisions for the Puget Sound region.

Nowcasting and Forecasting the Monthly Food Stamps Data in the US Using Online Search Data

PubMed Central

Fantazzini, Dean

2014-01-01

We propose the use of Google online search data for nowcasting and forecasting the number of food stamps recipients. We perform a large out-of-sample forecasting exercise with almost 3000 competing models with forecast horizons up to 2 years ahead, and we show that models including Google search data statistically outperform the competing models at all considered horizons. These results hold also with several robustness checks, considering alternative keywords, a falsification test, different out-of-samples, directional accuracy and forecasts at the state-level. PMID:25369315

Modelling of the AGS using Zgoubi - Status

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meot F.; Ahrens, L.; Dutheil, Y.

2012-05-20

This paper summarizes the progress achieved so far, and discusses various outcomes, regarding the development of a model of the Alternating Gradient Synchrotron at the RHIC collider. The model, based on stepwise ray-tracing methods, includes beam and polarization dynamics. This is an on-going work, and a follow-on of code developments and particle and spin dynamics simulations that have been subject to earlier publications at IPAC and PAC [1, 2, 3]. A companion paper [4] gives additional informations, regarding the use of the measured magnetic field maps of the AGS main magnets.

Skin models for the testing of transdermal drugs

PubMed Central

Abd, Eman; Yousef, Shereen A; Pastore, Michael N; Telaprolu, Krishna; Mohammed, Yousuf H; Namjoshi, Sarika; Grice, Jeffrey E; Roberts, Michael S

2016-01-01

The assessment of percutaneous permeation of molecules is a key step in the evaluation of dermal or transdermal delivery systems. If the drugs are intended for delivery to humans, the most appropriate setting in which to do the assessment is the in vivo human. However, this may not be possible for ethical, practical, or economic reasons, particularly in the early phases of development. It is thus necessary to find alternative methods using accessible and reproducible surrogates for in vivo human skin. A range of models has been developed, including ex vivo human skin, usually obtained from cadavers or plastic surgery patients, ex vivo animal skin, and artificial or reconstructed skin models. Increasingly, largely driven by regulatory authorities and industry, there is a focus on developing standardized techniques and protocols. With this comes the need to demonstrate that the surrogate models produce results that correlate with those from in vivo human studies and that they can be used to show bioequivalence of different topical products. This review discusses the alternative skin models that have been developed as surrogates for normal and diseased skin and examines the concepts of using model systems for in vitro–in vivo correlation and the demonstration of bioequivalence. PMID:27799831

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Young June; Ahn, Kwang Sung; Kim, Minjeong

Highlights: • ATM gene-targeted pigs were produced by somatic cell nuclear transfer. • A novel large animal model for ataxia telangiectasia was developed. • The new model may provide an alternative to the mouse model. - Abstract: Ataxia telangiectasia (A-T) is a recessive autosomal disorder associated with pleiotropic phenotypes, including progressive cerebellar degeneration, gonad atrophy, and growth retardation. Even though A-T is known to be caused by the mutations in the Ataxia telangiectasia mutated (ATM) gene, the correlation between abnormal cellular physiology caused by ATM mutations and the multiple symptoms of A-T disease has not been clearly determined. None ofmore » the existing ATM mouse models properly reflects the extent to which neurological degeneration occurs in human. In an attempt to provide a large animal model for A-T, we produced gene-targeted pigs with mutations in the ATM gene by somatic cell nuclear transfer. The disrupted allele in the ATM gene of cloned piglets was confirmed via PCR and Southern blot analysis. The ATM gene-targeted pigs generated in the present study may provide an alternative to the current mouse model for the study of mechanisms underlying A-T disorder and for the development of new therapies.« less

Food and energy choices for India: a programming model with partial endogenous energy requirements.

PubMed

Parikh, K S; Srinivasan, T N

1980-09-01

This paper presents a mathematical model for all matter-energy processing subsystems at the level of the society, specifically India. It explores India's choices in the food and energy sectors over the coming decades. Alternative land intensive, irrigation energy intensive, and fertilizer intensive techniques of food production are identified using a nonlinear programming model. The land saved is devoted to growing firewood. The optimum combination of railway (steam, diesel, and electric traction) and road (automobiles, diesel trucks, and diesel and gasoline buses) transport is determined. For the oil sector, two alternative sources of supply of crude oil and petroleum products are included, namely, domestic production and imports. The optimum choice is determined through a linear programming model. While the model is basically a static one, designed to determine the optimal choice for the target year of 2000-2001, certain intertemporal detail is incorporated for electricity generation. The model minimizes the costs of meeting the needs for food, transport in terms of passenger kilometers and goods per ton per kilometer, energy needs for domestic cooking and lighting, and the energy needs of the rest of the economy.

Alternative Energy Development and China's Energy Future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, Nina; Fridley, David

2011-06-15

In addition to promoting energy efficiency, China has actively pursued alternative energy development as a strategy to reduce its energy demand and carbon emissions. One area of particular focus has been to raise the share of alternative energy in China’s rapidly growing electricity generation with a 2020 target of 15% share of total primary energy. Over the last ten years, China has established several major renewable energy regulations along with programs and subsidies to encourage the growth of non-fossil alternative energy including solar, wind, nuclear, hydro, geothermal and biomass power as well as biofuels and coal alternatives. This study thusmore » seeks to examine China’s alternative energy in terms of what has and will continue to drive alternative energy development in China as well as analyze in depth the growth potential and challenges facing each specific technology. This study found that despite recent policies enabling extraordinary capacity and investment growth, alternative energy technologies face constraints and barriers to growth. For relatively new technologies that have not achieved commercialization such as concentrated solar thermal, geothermal and biomass power, China faces technological limitations to expanding the scale of installed capacity. While some alternative technologies such as hydropower and coal alternatives have been slowed by uneven and often changing market and policy support, others such as wind and solar PV have encountered physical and institutional barriers to grid integration. Lastly, all alternative energy technologies face constraints in human resources and raw material resources including land and water, with some facing supply limitations in critical elements such as uranium for nuclear, neodymium for wind and rare earth metals for advanced solar PV. In light of China’s potential for and barriers to growth, the resource and energy requirement for alternative energy technologies were modeled and scenario analysis used to evaluate the energy and emission impact of two pathways of alternative energy development. The results show that China can only meets its 2015 and 2020 targets for non-fossil penetration if it successfully achieves all of its capacity targets for 2020 with continued expansion through 2030. To achieve this level of alternative generation, significant amounts of raw materials including 235 Mt of concrete, 54 Mt of steel, 5 Mt of copper along with 3 billion tons of water and 64 thousand square kilometers of land are needed. China’s alternative energy supply will likely have relatively high average energy output to fossil fuel input ratio of 42 declining to 26 over time, but this ratio is largely skewed by nuclear and hydropower capacity. With successful alternative energy development, 32% of China’s electricity and 21% of its total primary energy will be supplied by alternative energy by 2030. Compared to the counterfactual baseline in which alternative energy development stumbles and China does not meet its capacity targets until 2030, alternative energy development can displace 175 Mtce of coal inputs per year and 2080 Mtce cumulatively from power generation by 2030. In carbon terms, this translates into 5520 Mt of displaced CO 2 emissions over the twenty year period, with more than half coming from expanded nuclear and wind power generation. These results illustrate the critical role that alternative energy development can play alongside energy efficiency in reducing China’s energy-related carbon emissions.« less

Stroke prevention in patients with atrial fibrillation in France: comparative cost-effectiveness of new oral anticoagulants (apixaban, dabigatran, and rivaroxaban), warfarin, and aspirin.

PubMed

Lanitis, T; Cotté, F E; Gaudin, A F; Kachaner, I; Kongnakorn, T; Durand-Zaleski, I

2014-08-01

To conduct an economic evaluation of the currently prescribed treatments for stroke prevention in patients with non-valvular atrial fibrillation (NVAF) including warfarin, aspirin, and novel oral anticoagulants (NOACs) from a French payer perspective. A previously published Markov model was adapted in accordance to the new French guidelines of the Commission for Economic Evaluation and Public Health (CEESP), to adopt the recommended efficiency frontier approach. A cohort of patients with NVAF eligible for stroke preventive treatment was simulated over lifetime. Clinical events modeled included strokes, systemic embolism, intracranial hemorrhage, other major bleeds, clinically relevant non-major bleeds, and myocardial infarction. Efficacy and bleeding data for warfarin, apixaban, and aspirin were obtained from ARISTOTLE and AVERROES trials, whilst efficacy data for other NOACs were from published indirect comparisons. Acute medical costs were obtained from a dedicated analysis of the French national hospitalization database (PMSI). Long-term medical costs and utility data were derived from the literature. Univariate and probabilistic sensitivity analyses were performed to assess the robustness of the model projections. Warfarin and apixaban were the two optimal treatment choices, as the other five treatment strategies including aspirin, dabigatran 110 mg, dabigatran in sequential dosages, dabigatran 150 mg, and rivaroxaban were strictly dominated on the efficiency frontier. Further, apixaban was a cost-effective alternative vs warfarin with an incremental cost of €2314 and an incremental quality-adjusted life year (QALY) of 0.189, corresponding to an incremental cost-effectiveness ratio (ICER) of €12,227/QALY. Apixaban may be the most economically efficient alternative to warfarin in NVAF patients eligible for stroke prevention in France. All other strategies were dominated, yielding apixaban as a less costly yet more effective treatment alternative. As formally requested by the CEESP, these results need to be verified in a French clinical setting using stroke reduction and bleeding safety observed in real-life patient cohorts using these anticoagulants.

Assessing the environmental burdens of anaerobic digestion in comparison to alternative options for managing the biodegradable fraction of municipal solid wastes.

PubMed

Haight, M

2005-01-01

Biological treatment processes including anaerobic digestion (biogasification) and composting are increasingly being considered by waste management officials and planners as alternatives for managing the mainly organic residues of municipal solid wastes (MSW). The integrated waste management model which is based upon the application of life-cycle analysis was employed to compare the environmental burdens of landfilling, composting and anaerobic digestion of MSW at a mid-sized Canadian community. Energy consumption (or recovery), residue recoveries and emissions to air and water were quantified. Scenario comparisons were analyzed to demonstrate that the environmental burdens associated with anaerobic digestion are reduced in comparison with the alternative options. The major benefit occurs as a result of the electricity produced from burning the biogas and then supplying the 'green power' to the local electrical grid.

Reply to "transforming oncology care": advancing value, accessing innovation.

PubMed

Paradis, Rebecca

2015-09-01

Alternative payment models in oncology are already successfully standardizing care, curbing costs, and improving the patient experience. Yet, it is unclear whether decision makers are adequately considering patient access to innovation when creating these models, which could have severe consequences for a robust innovation ecosystem and the lives of afflicted patients. The suggested chart includes recommendations on: Allowing for the adoption of new, promising therapies; Promoting the measurement of patient-centered outcomes; and Providing support for personalized medicine.

The radiology manager as a servant leader.

PubMed

Scott, Jason

2011-01-01

Servant leadership utilizes an alternative approach to power-based models by considering the needs of followers and collaborating with them to achieve organizational goals,which can generate higher staff satisfaction and promote a more positive working environment. Servant leadership principles include: listening, empathy, healing, awareness, persuasion, conceptualization, foresight, stewardship, commitment to the growth of people,and community building. Many researchers have addressed the need for healthcare organizations to adopt a servant leadership model because healthcare has an inherent servant nature.

Air Quality Dispersion Modeling - Alternative Models

EPA Pesticide Factsheets

Models, not listed in Appendix W, that can be used in regulatory applications with case-by-case justification to the Reviewing Authority as noted in Section 3.2, Use of Alternative Models, in Appendix W.

Where Are the Opportunities for Reducing Health Care Spending Within Alternative Payment Models?

PubMed

Rocque, Gabrielle B; Williams, Courtney P; Kenzik, Kelly M; Jackson, Bradford E; Halilova, Karina I; Sullivan, Margaret M; Rocconi, Rod P; Azuero, Andres; Kvale, Elizabeth A; Huh, Warner K; Partridge, Edward E; Pisu, Maria

2018-06-01

The Oncology Care Model (OCM) is a highly controversial specialty care model developed by the Centers for Medicare & Medicaid aimed to provide higher-quality care at lower cost. Because oncologists will be increasingly held accountable for spending as well as quality within new value-based health care models like the OCM, they need to understand the drivers of total spending for their patients. This retrospective cohort study included patients ≥ 65 years of age with primary fee-for-service Medicare insurance who received antineoplastic therapy at 12 cancer centers in the Southeast from 2012 to 2014. Medicare administrative claims data were used to identify health care spending during the prechemotherapy period (from cancer diagnosis to antineoplastic therapy initiation) and during the OCM episodes of care triggered by antineoplastic treatment. Total health care spending per episode includes all types of services received by a patient, including nononcology services. Spending was further characterized by type of service. Average total health care spending in the three OCM episodes of care was $33,838 (n = 3,427), $23,811 (n = 1,207), and $19,241 (n = 678). Antineoplastic drugs accounted for 27%, 32%, and 36% of total health care spending in the first, second, and third episodes. Ten drugs, used by 31% of patients, contributed 61% to drug spending ($18.8 million) in the first episode. Inpatient spending also substantially contributed to total costs, representing 17% to 20% ($30.5 million) of total health care spending. Health care spending was heavily driven by both antineoplastic drugs and hospital use. Oncologists' ability to affect these types of spending will determine their success under alternative payment models.

Development of Serum Marker Models to Increase Diagnostic Accuracy of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: The New LINKI Algorithm Compared with Established Algorithms.

PubMed

Lykiardopoulos, Byron; Hagström, Hannes; Fredrikson, Mats; Ignatova, Simone; Stål, Per; Hultcrantz, Rolf; Ekstedt, Mattias; Kechagias, Stergios

2016-01-01

Detection of advanced fibrosis (F3-F4) in nonalcoholic fatty liver disease (NAFLD) is important for ascertaining prognosis. Serum markers have been proposed as alternatives to biopsy. We attempted to develop a novel algorithm for detection of advanced fibrosis based on a more efficient combination of serological markers and to compare this with established algorithms. We included 158 patients with biopsy-proven NAFLD. Of these, 38 had advanced fibrosis. The following fibrosis algorithms were calculated: NAFLD fibrosis score, BARD, NIKEI, NASH-CRN regression score, APRI, FIB-4, King´s score, GUCI, Lok index, Forns score, and ELF. Study population was randomly divided in a training and a validation group. A multiple logistic regression analysis using bootstrapping methods was applied to the training group. Among many variables analyzed age, fasting glucose, hyaluronic acid and AST were included, and a model (LINKI-1) for predicting advanced fibrosis was created. Moreover, these variables were combined with platelet count in a mathematical way exaggerating the opposing effects, and alternative models (LINKI-2) were also created. Models were compared using area under the receiver operator characteristic curves (AUROC). Of established algorithms FIB-4 and King´s score had the best diagnostic accuracy with AUROCs 0.84 and 0.83, respectively. Higher accuracy was achieved with the novel LINKI algorithms. AUROCs in the total cohort for LINKI-1 was 0.91 and for LINKI-2 models 0.89. The LINKI algorithms for detection of advanced fibrosis in NAFLD showed better accuracy than established algorithms and should be validated in further studies including larger cohorts.

Neuromechanistic Model of Auditory Bistability

PubMed Central

Rankin, James; Sussman, Elyse; Rinzel, John

2015-01-01

Sequences of higher frequency A and lower frequency B tones repeating in an ABA- triplet pattern are widely used to study auditory streaming. One may experience either an integrated percept, a single ABA-ABA- stream, or a segregated percept, separate but simultaneous streams A-A-A-A- and -B---B--. During minutes-long presentations, subjects may report irregular alternations between these interpretations. We combine neuromechanistic modeling and psychoacoustic experiments to study these persistent alternations and to characterize the effects of manipulating stimulus parameters. Unlike many phenomenological models with abstract, percept-specific competition and fixed inputs, our network model comprises neuronal units with sensory feature dependent inputs that mimic the pulsatile-like A1 responses to tones in the ABA- triplets. It embodies a neuronal computation for percept competition thought to occur beyond primary auditory cortex (A1). Mutual inhibition, adaptation and noise are implemented. We include slow NDMA recurrent excitation for local temporal memory that enables linkage across sound gaps from one triplet to the next. Percepts in our model are identified in the firing patterns of the neuronal units. We predict with the model that manipulations of the frequency difference between tones A and B should affect the dominance durations of the stronger percept, the one dominant a larger fraction of time, more than those of the weaker percept—a property that has been previously established and generalized across several visual bistable paradigms. We confirm the qualitative prediction with our psychoacoustic experiments and use the behavioral data to further constrain and improve the model, achieving quantitative agreement between experimental and modeling results. Our work and model provide a platform that can be extended to consider other stimulus conditions, including the effects of context and volition. PMID:26562507

Linking linear programming and spatial simulation models to predict landscape effects of forest management alternatives

Treesearch

Eric J. Gustafson; L. Jay Roberts; Larry A. Leefers

2006-01-01

Forest management planners require analytical tools to assess the effects of alternative strategies on the sometimes disparate benefits from forests such as timber production and wildlife habitat. We assessed the spatial patterns of alternative management strategies by linking two models that were developed for different purposes. We used a linear programming model (...

From the Tightrope: Designing, Developing, and Delivering an Alternative Teacher Education Model

ERIC Educational Resources Information Center

Yancey, Patty

2006-01-01

In the fall of 2003 a number of factors came together to create a fertile environment for developing an alternative, pre-service teacher education model. The overarching goal of the model is to diversify a rural university's credential program(s) by developing and offering alternative paths toward teacher certification within the constraints of a…

Overload, autonomy, and burnout as predictors of physicians' quality of care.

PubMed

Shirom, Arie; Nirel, Nurit; Vinokur, Amiram D

2006-10-01

A model in which perceived overload and burnout mediated the relations of workload and autonomy with physicians' quality of care to their patients was examined. The study was based on data from 890 specialists representing six medical specialties. Including global burnout as well as its three first-order facets of physical fatigue, cognitive weariness, and emotional exhaustion improved the fit between the structural model and the data relative to an alternative model that included only global burnout. Workload (number of work hours) indirectly predicted quality of care through perceived overload. Additionally, the authors found that the paths from the first order factors of emotional exhaustion, physical fatigue, and cognitive weariness predicted quality of care negatively, positively, and nonsignificantly, respectively.

Radiation Physics for Space and High Altitude Air Travel

NASA Technical Reports Server (NTRS)

Cucinotta, F. A.; Wilson, J. W.; Goldhagen, P.; Saganti, P.; Shavers, M. R.; McKay, Gordon A. (Technical Monitor)

2000-01-01

Galactic cosmic rays (GCR) are of extra-solar origin consisting of high-energy hydrogen, helium, and heavy ions. The GCR are modified by physical processes as they traverse through the solar system, spacecraft shielding, atmospheres, and tissues producing copious amounts of secondary radiation including fragmentation products, neutrons, mesons, and muons. We discuss physical models and measurements relevant for estimating biological risks in space and high-altitude air travel. Ambient and internal spacecraft computational models for the International Space Station and a Mars mission are discussed. Risk assessment is traditionally based on linear addition of components. We discuss alternative models that include stochastic treatments of columnar damage by heavy ion tracks and multi-cellular damage following nuclear fragmentation in tissue.

A utility-based design for randomized comparative trials with ordinal outcomes and prognostic subgroups.

PubMed

Murray, Thomas A; Yuan, Ying; Thall, Peter F; Elizondo, Joan H; Hofstetter, Wayne L

2018-01-22

A design is proposed for randomized comparative trials with ordinal outcomes and prognostic subgroups. The design accounts for patient heterogeneity by allowing possibly different comparative conclusions within subgroups. The comparative testing criterion is based on utilities for the levels of the ordinal outcome and a Bayesian probability model. Designs based on two alternative models that include treatment-subgroup interactions are considered, the proportional odds model and a non-proportional odds model with a hierarchical prior that shrinks toward the proportional odds model. A third design that assumes homogeneity and ignores possible treatment-subgroup interactions also is considered. The three approaches are applied to construct group sequential designs for a trial of nutritional prehabilitation versus standard of care for esophageal cancer patients undergoing chemoradiation and surgery, including both untreated patients and salvage patients whose disease has recurred following previous therapy. A simulation study is presented that compares the three designs, including evaluation of within-subgroup type I and II error probabilities under a variety of scenarios including different combinations of treatment-subgroup interactions. © 2018, The International Biometric Society.

26 CFR 20.2032-1 - Alternate valuation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... alternate valuation method under section 2032, the property included in the decedent's gross estate on the..., the alternate valuation method applies to all property included in the gross estate and cannot be... elects the alternate valuation method under section 2432, all property interests existing at the date of...

An Empirical Comparison of Competing Factor Structures for the Repeatable Battery for the Assessment of Neuropsychological Status: A Project FRONTIER Study†

PubMed Central

Torrence, Nicole D.; John, Samantha E.; Gavett, Brandon E.; O'Bryant, Sid E.

2016-01-01

The original factor structure of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has received little empirical support, but at least eight alternative factor structures have been identified in the literature. The current study used confirmatory factor analysis to compare the original RBANS model with eight alternatives, which were adjusted to include a general factor. Participant data were obtained from Project FRONTIER, an epidemiological study of rural health, and comprised 341 adults (229 women, 112 men) with mean age of 61.2 years (SD = 12.1) and mean education of 12.4 years (SD = 3.3). A bifactor version of the model proposed by Duff and colleagues provided the best fit to the data (CFI = 0.98; root-mean-squared error of approximation = 0.07), but required further modification to produce appropriate factor loadings. The results support the inclusion of a general factor and provide partial replication of the Duff and colleagues RBANS model. PMID:26429558

Through the looking glass: why the `cosmic horizon' is not a horizon

NASA Astrophysics Data System (ADS)

van Oirschot, Pim; Kwan, Juliana; Lewis, Geraint F.

2010-06-01

The present standard model of cosmology, Λ cold dark matter (ΛCDM), contains some intriguing coincidences. Not only are the dominant contributions to the energy density approximately of the same order at the present epoch, but we also note that contrary to the emergence of cosmic acceleration as a recent phenomenon, the time-averaged value of the deceleration parameter over the age of the Universe is nearly zero. Curious features like these in ΛCDM give rise to a number of alternate cosmologies being proposed to remove them, including models with an equation of state w = -1/3. In this paper, we examine the validity of some of these alternate models and we also address some persistent misconceptions about the Hubble sphere and the event horizon that lead to erroneous conclusions about cosmology. Research undertaken as part of the Commonwealth Cosmology Initiative (CCI: http://www.thecci.org), an international collaboration supported by the Australian Research Council. E-mail: pimvanoirschot@gmail.com

The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development.

PubMed

Rodor, Julie; FitzPatrick, David R; Eyras, Eduardo; Cáceres, Javier F

2017-01-02

Mutations in the RNA-binding protein, RBM10, result in a human syndromic form of cleft palate, termed TARP syndrome. A role for RBM10 in alternative splicing regulation has been previously demonstrated in human cell lines. To uncover the cellular functions of RBM10 in a cell line that is relevant to the phenotype observed in TARP syndrome, we used iCLIP to identify its endogenous RNA targets in a mouse embryonic mandibular cell line. We observed that RBM10 binds to pre-mRNAs with significant enrichment in intronic regions, in agreement with a role for this protein in pre-mRNA splicing. In addition to protein-coding transcripts, RBM10 also binds to a variety of cellular RNAs, including non-coding RNAs, such as spliceosomal small nuclear RNAs, U2 and U12. RNA-seq was used to investigate changes in gene expression and alternative splicing in RBM10 KO mouse mandibular cells and also in mouse ES cells. We uncovered a role for RBM10 in the regulation of alternative splicing of common transcripts in both cell lines but also identified cell-type specific events. Importantly, those pre-mRNAs that display changes in alternative splicing also contain RBM10 iCLIP tags, suggesting a direct role of RBM10 in these events. Finally, we show that depletion of RBM10 in mouse ES cells leads to proliferation defects and to gross alterations in their differentiation potential. These results demonstrate a role for RBM10 in the regulation of alternative splicing in two cell models of mouse early development and suggests that mutations in RBM10 could lead to splicing changes that affect normal palate development and cause human disease.

Genome-Scale Analysis of Translation Elongation with a Ribosome Flow Model

PubMed Central

Meilijson, Isaac; Kupiec, Martin; Ruppin, Eytan

2011-01-01

We describe the first large scale analysis of gene translation that is based on a model that takes into account the physical and dynamical nature of this process. The Ribosomal Flow Model (RFM) predicts fundamental features of the translation process, including translation rates, protein abundance levels, ribosomal densities and the relation between all these variables, better than alternative (‘non-physical’) approaches. In addition, we show that the RFM can be used for accurate inference of various other quantities including genes' initiation rates and translation costs. These quantities could not be inferred by previous predictors. We find that increasing the number of available ribosomes (or equivalently the initiation rate) increases the genomic translation rate and the mean ribosome density only up to a certain point, beyond which both saturate. Strikingly, assuming that the translation system is tuned to work at the pre-saturation point maximizes the predictive power of the model with respect to experimental data. This result suggests that in all organisms that were analyzed (from bacteria to Human), the global initiation rate is optimized to attain the pre-saturation point. The fact that similar results were not observed for heterologous genes indicates that this feature is under selection. Remarkably, the gap between the performance of the RFM and alternative predictors is strikingly large in the case of heterologous genes, testifying to the model's promising biotechnological value in predicting the abundance of heterologous proteins before expressing them in the desired host. PMID:21909250

Analytical steady-state solutions for water-limited cropping systems using saline irrigation water

NASA Astrophysics Data System (ADS)

Skaggs, T. H.; Anderson, R. G.; Corwin, D. L.; Suarez, D. L.

2014-12-01

Due to the diminishing availability of good quality water for irrigation, it is increasingly important that irrigation and salinity management tools be able to target submaximal crop yields and support the use of marginal quality waters. In this work, we present a steady-state irrigated systems modeling framework that accounts for reduced plant water uptake due to root zone salinity. Two explicit, closed-form analytical solutions for the root zone solute concentration profile are obtained, corresponding to two alternative functional forms of the uptake reduction function. The solutions express a general relationship between irrigation water salinity, irrigation rate, crop salt tolerance, crop transpiration, and (using standard approximations) crop yield. Example applications are illustrated, including the calculation of irrigation requirements for obtaining targeted submaximal yields, and the generation of crop-water production functions for varying irrigation waters, irrigation rates, and crops. Model predictions are shown to be mostly consistent with existing models and available experimental data. Yet the new solutions possess advantages over available alternatives, including: (i) the solutions were derived from a complete physical-mathematical description of the system, rather than based on an ad hoc formulation; (ii) the analytical solutions are explicit and can be evaluated without iterative techniques; (iii) the solutions permit consideration of two common functional forms of salinity induced reductions in crop water uptake, rather than being tied to one particular representation; and (iv) the utilized modeling framework is compatible with leading transient-state numerical models.

Strategy for modeling putative multilevel ecosystems on Europa.

PubMed

Irwin, Louis N; Schulze-Makuch, Dirk

2003-01-01

A general strategy for modeling ecosystems on other worlds is described. Two alternative biospheres beneath the ice surface of Europa are modeled, based on analogous ecosystems on Earth in potentially comparable habitats, with reallocation of biomass quantities consistent with different sources of energy and chemical constituents. The first ecosystem models a benthic biosphere supported by chemoautotrophic producers. The second models two concentrations of biota at the top and bottom of the subsurface water column supported by energy harvested from transmembrane ionic gradients. Calculations indicate the plausibility of both ecosystems, including small macroorganisms at the highest trophic levels, with ionotrophy supporting a larger biomass than chemoautotrophy.

Life cycle models of conventional and alternative-fueled automobiles

NASA Astrophysics Data System (ADS)

Maclean, Heather Louise

This thesis reports life cycle inventories of internal combustion engine automobiles with feasible near term fuel/engine combinations. These combinations include unleaded gasoline, California Phase 2 Reformulated Gasoline, alcohol and gasoline blends (85 percent methanol or ethanol combined with 15 percent gasoline), and compressed natural gas in spark ignition direct and indirect injection engines. Additionally, I consider neat methanol and neat ethanol in spark ignition direct injection engines and diesel fuel in compression ignition direct and indirect injection engines. I investigate the potential of the above options to have a lower environmental impact than conventional gasoline-fueled automobiles, while still retaining comparable pricing and consumer benefits. More broadly, the objective is to assess whether the use of any of the alternative systems will help to lead to the goal of a more sustainable personal transportation system. The principal tool is the Economic Input-Output Life Cycle Analysis model which includes inventories of economic data, environmental discharges, and resource use. I develop a life cycle assessment framework to assemble the array of data generated by the model into three aggregate assessment parameters; economics, externalities, and vehicle attributes. The first step is to develop a set of 'comparable cars' with the alternative fuel/engine combinations, based on characteristics of a conventional 1998 gasoline-fueled Ford Taurus sedan, the baseline vehicle for the analyses. I calculate the assessment parameters assuming that these comparable cars can attain the potential thermal efficiencies estimated by experts for each fuel/engine combination. To a first approximation, there are no significant differences in the assessment parameters for the vehicle manufacture, service, fixed costs, and the end-of-life for any of the options. However, there are differences in the vehicle operation life cycle components and the state of technology development for the combinations. Overall, none of the alternatives emerges as a clear winner, lowering the externalities and improving sustainability, while considering technology issues and vehicle attributes. The majority of the alternatives are not likely to displace the baseline automobile. However, the attractiveness of the alternatives depends on the focus of future regulations, government priorities, and technology development. If long-term global sustainability is the principal concern, then improvements in fuel economy alone will not provide the level of reduction in impact required. A switch to renewable fuels (e.g., alcohols or diesel produced from biomass) to power the vehicles will likely be necessary. (Abstract shortened by UMI.)

The 2-year cost-effectiveness of 3 options to treat lumbar spinal stenosis patients.

PubMed

Udeh, Belinda L; Costandi, Shrif; Dalton, Jarrod E; Ghosh, Raktim; Yousef, Hani; Mekhail, Nagy

2015-02-01

Lumbar spinal stenosis (LSS) may result from degenerative changes of the spine, which lead to neural ischemia, neurogenic claudication, and a significant decrease in quality of life. Treatments for LSS range from conservative management including epidural steroid injections (ESI) to laminectomy surgery. Treatments vary greatly in cost and success. ESI is the least costly treatment may be successful for early stages of LSS but often must be repeated frequently. Laminectomy surgery is more costly and has higher complication rates. Minimally invasive lumbar decompression (mild(®) ) is an alternative. Using a decision-analytic model from the Medicare perspective, a cost-effectiveness analysis was performed comparing mild(®) to ESI or laminectomy surgery. The analysis population included patients with LSS who have moderate to severe symptoms and have failed conservative therapy. Costs included initial procedure, complications, and repeat/revision or alternate procedure after failure. Effects measured as change in quality-adjusted life years (QALY) from preprocedure to 2 years postprocedure. Incremental cost-effectiveness ratios were determined, and sensitivity analysis conducted. The mild(®) strategy appears to be the most cost-effective ($43,760/QALY), with ESI the next best alternative at an additional $37,758/QALY. Laminectomy surgery was the least cost-effective ($125,985/QALY). © 2014 World Institute of Pain.

Testing the limits of long-distance learning: Learning beyond a three-segment window

PubMed Central

Finley, Sara

2012-01-01

Traditional flat-structured bigram and trigram models of phonotactics are useful because they capture a large number of facts about phonological processes. Additionally, these models predict that local interactions should be easier to learn than long-distance ones since long-distance dependencies are difficult to capture with these models. Long-distance phonotactic patterns have been observed by linguists in many languages, who have proposed different kinds of models, including feature-based bigram and trigram models, as well as precedence models. Contrary to flat-structured bigram and trigram models, these alternatives capture unbounded dependencies because at an abstract level of representation, the relevant elements are locally dependent, even if they are not adjacent at the observable level. Using an artificial grammar learning paradigm, we provide additional support for these alternative models of phonotactics. Participants in two experiments were exposed to a long-distance consonant harmony pattern in which the first consonant of a five-syllable word was [s] or [∫] ('sh') and triggered a suffix that was either [−su] or [−∫u] depending on the sibilant quality of this first consonant. Participants learned this pattern, despite the large distance between the trigger and the target, suggesting that when participants learn long-distance phonological patterns, that pattern is learned without specific reference to distance. PMID:22303815

Ultrathin Ceramic Membranes as Scaffolds for Functional Cell Coculture Models on a Biomimetic Scale

PubMed Central

Jud, Corinne; Ahmed, Sher; Müller, Loretta; Kinnear, Calum; Vanhecke, Dimitri; Umehara, Yuki; Frey, Sabine; Liley, Martha; Angeloni, Silvia; Petri-Fink, Alke; Rothen-Rutishauser, Barbara

2015-01-01

Abstract Epithelial tissue serves as an interface between biological compartments. Many in vitro epithelial cell models have been developed as an alternative to animal experiments to answer a range of research questions. These in vitro models are grown on permeable two-chamber systems; however, commercially available, polymer-based cell culture inserts are around 10 μm thick. Since the basement membrane found in biological systems is usually less than 1 μm thick, the 10-fold thickness of cell culture inserts is a major limitation in the establishment of realistic models. In this work, an alternative insert, accommodating an ultrathin ceramic membrane with a thickness of only 500 nm (i.e., the Silicon nitride Microporous Permeable Insert [SIMPLI]-well), was produced and used to refine an established human alveolar barrier coculture model by both replacing the conventional inserts with the SIMPLI-well and completing it with endothelial cells. The structural–functional relationship of the model was evaluated, including the translocation of gold nanoparticles across the barrier, revealing a higher translocation if compared to corresponding polyethylene terephthalate (PET) membranes. This study demonstrates the power of the SIMPLI-well system as a scaffold for epithelial tissue cell models on a truly biomimetic scale, allowing construction of more functionally accurate models of human biological barriers. PMID:26713225

Annual Energy Outlook 2016 With Projections to 2040

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Annual Energy Outlook 2016 (AEO2016), prepared by the U.S. Energy Information Administration (EIA), presents long-term projections of energy supply, demand, and prices through 2040. The projections, focused on U.S. energy markets, are based on results from EIA’s National Energy Modeling System (NEMS). NEMS enables EIA to make projections under alternative, internallyconsistent sets of assumptions. The analysis in AEO2016 focuses on the Reference case and 17 alternative cases. EIA published an Early Release version of the AEO2016 Reference case (including U.S. Environmental Protection Agency’s (EPA) Clean Power Plan (CPP)) and a No CPP case (excluding the CPP) in May 2016.

The individual and beyond: a socio-rational choice model of service participation among homeless adults with substance abuse problems.

PubMed

Sosin, Michael R; Grossman, Susan F

2003-01-01

While substance user service programs can help homeless adults solve their substance use and housing problems, relatively few needy individuals use and complete these programs. The lack of participation is poorly explained by typical empirical studies, most of which consider the role in service participation of various personal traits and client problems. The current article instead seeks to explain service participation through the application of an alternative, "socio-rational choice" model. This model has three premises: Clients weigh the costs and benefits of participating in services against alternative uses of their time and resources. The clients' weighing procedures reflect their personal situations and perceptions of the treatment environment. The perceptions of their personal situations and perceptions of the treatment environment are affected by the manner in which clients react to representatives of service systems, members of their social network including both housed and homeless persons, and other individuals. Secondary evidence supports many of the model's hypotheses and generally suggests that homeless clients may be heavily affected by their experiences with individuals and systems with which they come into contact.

The impact of fishing-induced mortality on the evolution of alternative life-history tactics in brook charr

PubMed Central

Thériault, Véronique; Dunlop, Erin S; Dieckmann, Ulf; Bernatchez, Louis; Dodson, Julian J

2008-01-01

Although contemporary trends indicative of evolutionary change have been detected in the life-history traits of exploited populations, it is not known to what extent fishing influences the evolution of alternative life-history tactics in migratory species such as salmonids. Here, we build a model to predict the evolution of anadromy and residency in an exploited population of brook charr, Salvelinus fontinalis. Our model allows for both phenotypic plasticity and genetic change in the age and size at migration by including migration reaction norms. Using this model, we predict that fishing of anadromous individuals over the course of 100 years causes evolution in the migration reaction norm, resulting in a decrease in average probabilities of migration with increasing harvest rate. Moreover, we show that differences in natural mortalities in freshwater greatly influence the magnitude and rate of evolutionary change. The fishing-induced changes in migration predicted by our model alter population abundances and reproductive output and should be accounted for in the sustainable management of salmonids. PMID:25567640

Escaping the snare of chronological growth and launching a free curve alternative: general deviance as latent growth model.

PubMed

Wood, Phillip Karl; Jackson, Kristina M

2013-08-01

Researchers studying longitudinal relationships among multiple problem behaviors sometimes characterize autoregressive relationships across constructs as indicating "protective" or "launch" factors or as "developmental snares." These terms are used to indicate that initial or intermediary states of one problem behavior subsequently inhibit or promote some other problem behavior. Such models are contrasted with models of "general deviance" over time in which all problem behaviors are viewed as indicators of a common linear trajectory. When fit of the "general deviance" model is poor and fit of one or more autoregressive models is good, this is taken as support for the inhibitory or enhancing effect of one construct on another. In this paper, we argue that researchers consider competing models of growth before comparing deviance and time-bound models. Specifically, we propose use of the free curve slope intercept (FCSI) growth model (Meredith & Tisak, 1990) as a general model to typify change in a construct over time. The FCSI model includes, as nested special cases, several statistical models often used for prospective data, such as linear slope intercept models, repeated measures multivariate analysis of variance, various one-factor models, and hierarchical linear models. When considering models involving multiple constructs, we argue the construct of "general deviance" can be expressed as a single-trait multimethod model, permitting a characterization of the deviance construct over time without requiring restrictive assumptions about the form of growth over time. As an example, prospective assessments of problem behaviors from the Dunedin Multidisciplinary Health and Development Study (Silva & Stanton, 1996) are considered and contrasted with earlier analyses of Hussong, Curran, Moffitt, and Caspi (2008), which supported launch and snare hypotheses. For antisocial behavior, the FCSI model fit better than other models, including the linear chronometric growth curve model used by Hussong et al. For models including multiple constructs, a general deviance model involving a single trait and multimethod factors (or a corresponding hierarchical factor model) fit the data better than either the "snares" alternatives or the general deviance model previously considered by Hussong et al. Taken together, the analyses support the view that linkages and turning points cannot be contrasted with general deviance models absent additional experimental intervention or control.

Escaping the snare of chronological growth and launching a free curve alternative: General deviance as latent growth model

PubMed Central

WOOD, PHILLIP KARL; JACKSON, KRISTINA M.

2014-01-01

Researchers studying longitudinal relationships among multiple problem behaviors sometimes characterize autoregressive relationships across constructs as indicating “protective” or “launch” factors or as “developmental snares.” These terms are used to indicate that initial or intermediary states of one problem behavior subsequently inhibit or promote some other problem behavior. Such models are contrasted with models of “general deviance” over time in which all problem behaviors are viewed as indicators of a common linear trajectory. When fit of the “general deviance” model is poor and fit of one or more autoregressive models is good, this is taken as support for the inhibitory or enhancing effect of one construct on another. In this paper, we argue that researchers consider competing models of growth before comparing deviance and time-bound models. Specifically, we propose use of the free curve slope intercept (FCSI) growth model (Meredith & Tisak, 1990) as a general model to typify change in a construct over time. The FCSI model includes, as nested special cases, several statistical models often used for prospective data, such as linear slope intercept models, repeated measures multivariate analysis of variance, various one-factor models, and hierarchical linear models. When considering models involving multiple constructs, we argue the construct of “general deviance” can be expressed as a single-trait multimethod model, permitting a characterization of the deviance construct over time without requiring restrictive assumptions about the form of growth over time. As an example, prospective assessments of problem behaviors from the Dunedin Multidisciplinary Health and Development Study (Silva & Stanton, 1996) are considered and contrasted with earlier analyses of Hussong, Curran, Moffitt, and Caspi (2008), which supported launch and snare hypotheses. For antisocial behavior, the FCSI model fit better than other models, including the linear chronometric growth curve model used by Hussong et al. For models including multiple constructs, a general deviance model involving a single trait and multimethod factors (or a corresponding hierarchical factor model) fit the data better than either the “snares” alternatives or the general deviance model previously considered by Hussong et al. Taken together, the analyses support the view that linkages and turning points cannot be contrasted with general deviance models absent additional experimental intervention or control. PMID:23880389

Transient Inverse Calibration of Site-Wide Groundwater Model to Hanford Operational Impacts from 1943 to 1996--Alternative Conceptual Model Considering Interaction with Uppermost Basalt Confined Aquifer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vermeul, Vincent R.; Cole, Charles R.; Bergeron, Marcel P.

2001-08-29

The baseline three-dimensional transient inverse model for the estimation of site-wide scale flow parameters, including their uncertainties, using data on the transient behavior of the unconfined aquifer system over the entire historical period of Hanford operations, has been modified to account for the effects of basalt intercommunication between the Hanford unconfined aquifer and the underlying upper basalt confined aquifer. Both the baseline and alternative conceptual models (ACM-1) considered only the groundwater flow component and corresponding observational data in the 3-Dl transient inverse calibration efforts. Subsequent efforts will examine both groundwater flow and transport. Comparisons of goodness of fit measures andmore » parameter estimation results for the ACM-1 transient inverse calibrated model with those from previous site-wide groundwater modeling efforts illustrate that the new 3-D transient inverse model approach will strengthen the technical defensibility of the final model(s) and provide the ability to incorporate uncertainty in predictions related to both conceptual model and parameter uncertainty. These results, however, indicate that additional improvements are required to the conceptual model framework. An investigation was initiated at the end of this basalt inverse modeling effort to determine whether facies-based zonation would improve specific yield parameter estimation results (ACM-2). A description of the justification and methodology to develop this zonation is discussed.« less

Study protocol for a comparative effectiveness trial of two models of perinatal integrated psychosocial assessment: the PIPA project.

PubMed

Reilly, Nicole; Black, Emma; Chambers, Georgina M; Schmied, Virginia; Matthey, Stephen; Farrell, Josephine; Kingston, Dawn; Bisits, Andrew; Austin, Marie-Paule

2017-07-20

Studies examining psychosocial and depression assessment programs in maternity settings have not adequately considered the context in which psychosocial assessment occurs or how broader components of integrated care, including clinician decision-making aids, may optimise program delivery and its cost-effectiveness. There is also limited evidence relating to the diagnostic accuracy of symptom-based screening measures used in this context. The Perinatal Integrated Psychosocial Assessment (PIPA) Project was developed to address these knowledge gaps. The primary aims of the PIPA Project are to examine the clinical- and cost-effectiveness of two alternative models of integrated psychosocial care during pregnancy: 'care as usual' (the SAFE START model) and an alternative model (the PIPA model). The acceptability and perceived benefit of each model of care from the perspective of both pregnant women and their healthcare providers will also be assessed. Our secondary aim is to examine the psychometric properties of a number of symptom-based screening tools for depression and anxiety when used in pregnancy. This is a comparative-effectiveness study comparing 'care as usual' to an alternative model sequentially over two 12-month periods. Data will be collected from women at Time 1 (initial antenatal psychosocial assessment), Time 2 (2-weeks after Time 1) and from clinicians at Time 3 for each condition. Primary aims will be evaluated using a between-groups design, and the secondary aim using a within group design. The PIPA Project will provide evidence relating to the clinical- and cost- effectiveness of psychosocial assessment integrated with electronic clinician decision making prompts, and referral options that are tailored to the woman's psychosocial risk, in the maternity care setting. It will also address research recommendations from the Australian (2011) and NICE (2015) Clinical Practice Guidelines. ACTRN12617000932369.

Time dependent data, time independent models: challenges of updating Australia's National Seismic Hazard Assessment

NASA Astrophysics Data System (ADS)

Griffin, J.; Clark, D.; Allen, T.; Ghasemi, H.; Leonard, M.

2017-12-01

Standard probabilistic seismic hazard assessment (PSHA) simulates earthquake occurrence as a time-independent process. However paleoseismic studies in slowly deforming regions such as Australia show compelling evidence that large earthquakes on individual faults cluster within active periods, followed by long periods of quiescence. Therefore the instrumental earthquake catalog, which forms the basis of PSHA earthquake recurrence calculations, may only capture the state of the system over the period of the catalog. Together this means that data informing our PSHA may not be truly time-independent. This poses challenges in developing PSHAs for typical design probabilities (such as 10% in 50 years probability of exceedance): Is the present state observed through the instrumental catalog useful for estimating the next 50 years of earthquake hazard? Can paleo-earthquake data, that shows variations in earthquake frequency over time-scales of 10,000s of years or more, be robustly included in such PSHA models? Can a single PSHA logic tree be useful over a range of different probabilities of exceedance? In developing an updated PSHA for Australia, decadal-scale data based on instrumental earthquake catalogs (i.e. alternative area based source models and smoothed seismicity models) is integrated with paleo-earthquake data through inclusion of a fault source model. Use of time-dependent non-homogeneous Poisson models allows earthquake clustering to be modeled on fault sources with sufficient paleo-earthquake data. This study assesses the performance of alternative models by extracting decade-long segments of the instrumental catalog, developing earthquake probability models based on the remaining catalog, and testing performance against the extracted component of the catalog. Although this provides insights into model performance over the short-term, for longer timescales it is recognised that model choice is subject to considerable epistemic uncertainty. Therefore a formal expert elicitation process has been used to assign weights to alternative models for the 2018 update to Australia's national PSHA.

Promotion of alternative-sized personal protective equipment.

PubMed

Flynn, Michael A; Keller, Brenna; DeLaney, Sheli C

2017-12-01

With more diversity in the workforce, companies are producing PPE such as hard hats, safety glasses, coveralls, foot protection, and safety harnesses for a larger range of body shapes and sizes. However, gray literature reports suggest that barriers exist to getting alternate sized PPE from the manufacturer to the workers who need it. The purpose of this study is to determine the extent to which alternative-sized PPE is marketed. A web-based review of seven major manufacturers of PPE was conducted to determine: (a) whether or not they offer alternative-sized products, (b) if these products are clearly labeled, and (c) if images used to display PPE are representative of a diverse workforce. Of the seven PPE manufacturers investigated, six had at least one product that was marketed as gender and/or size alternatives however, alternative sizes were more common for larger body types. Alternative-sized products rarely included size charts, and the models used to display PPE were overwhelmingly white males of average size. Despite the growing availability of alternative-sized PPE, it can be difficult to find these products, which suggests that they are rarely promoted or labeled as alternative-sized. Our study indicates that companies should expand their product lines and more aggressively market and promote these items. Guidance on how to properly fit their products would also be extremely helpful to the end-user. Manufacturers could improve the availability of alternative-sized PPE and increase their promotion of these products on their websites and in their catalogs. Individual companies and safety professionals may assist in this process by demonstrating demand for alternative-sized PPE. Published by Elsevier Ltd.

Lease vs. Purchase Analysis of Alternative Fuel Vehicles in the United States Marine Corps

DTIC Science & Technology

2009-12-01

data (2004 to 2009) for the largest populations of AFVs in the light-duty category and then apply a model that will compare the two alternatives based...the largest populations of AFVs in the light-duty category and then apply a model that will compare the two alternatives based on their relative net...28 IV. THE MODEL

Lease VS Purchase Analysis of Alternative Fuel Vehicles in the United States Marine Corps

DTIC Science & Technology

2009-10-30

the light-duty category and then apply a model that will compare the two alternatives based on their relative net present values. An aggregated view of... model that will compare the two alternatives based on their relative net present values. An aggregated view of several different light-duty AFV...Summary .......................................................................................32  IV.  The Model

An Alternative Model of Music Learning and "Last Night's Fun": Participatory Music Making In/As Participatory Culture in Irish Traditional Music

ERIC Educational Resources Information Center

Waldron, Janice

2016-01-01

Exploring emergent music learning and teaching models facilitated by global Web access can reveal alternative music education practices and delivery systems not seen in "traditional" conservatories and schools. One example of an alternative music learning model comes from the Online Academy of Irish Music (OAIM), a community music…

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2013 CFR

2013-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2011 CFR

2011-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2014 CFR

2014-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2010 CFR

2010-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

40 CFR 1502.14 - Alternatives including the proposed action.

Code of Federal Regulations, 2012 CFR

2012-07-01

... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives not...

Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

PubMed Central

2014-01-01

Background Striking a balance between the degree of model complexity and parameter identifiability, while still producing biologically feasible simulations using modelling is a major challenge in computational biology. While these two elements of model development are closely coupled, parameter fitting from measured data and analysis of model mechanisms have traditionally been performed separately and sequentially. This process produces potential mismatches between model and data complexities that can compromise the ability of computational frameworks to reveal mechanistic insights or predict new behaviour. In this study we address this issue by presenting a generic framework for combined model parameterisation, comparison of model alternatives and analysis of model mechanisms. Results The presented methodology is based on a combination of multivariate metamodelling (statistical approximation of the input–output relationships of deterministic models) and a systematic zooming into biologically feasible regions of the parameter space by iterative generation of new experimental designs and look-up of simulations in the proximity of the measured data. The parameter fitting pipeline includes an implicit sensitivity analysis and analysis of parameter identifiability, making it suitable for testing hypotheses for model reduction. Using this approach, under-constrained model parameters, as well as the coupling between parameters within the model are identified. The methodology is demonstrated by refitting the parameters of a published model of cardiac cellular mechanics using a combination of measured data and synthetic data from an alternative model of the same system. Using this approach, reduced models with simplified expressions for the tropomyosin/crossbridge kinetics were found by identification of model components that can be omitted without affecting the fit to the parameterising data. Our analysis revealed that model parameters could be constrained to a standard deviation of on average 15% of the mean values over the succeeding parameter sets. Conclusions Our results indicate that the presented approach is effective for comparing model alternatives and reducing models to the minimum complexity replicating measured data. We therefore believe that this approach has significant potential for reparameterising existing frameworks, for identification of redundant model components of large biophysical models and to increase their predictive capacity. PMID:24886522

Big bang nucleosynthesis - The standard model and alternatives

NASA Technical Reports Server (NTRS)

Schramm, David N.

1991-01-01

The standard homogeneous-isotropic calculation of the big bang cosmological model is reviewed, and alternate models are discussed. The standard model is shown to agree with the light element abundances for He-4, H-2, He-3, and Li-7 that are available. Improved observational data from recent LEP collider and SLC results are discussed. The data agree with the standard model in terms of the number of neutrinos, and provide improved information regarding neutron lifetimes. Alternate models are reviewed which describe different scenarios for decaying matter or quark-hadron induced inhomogeneities. The baryonic density relative to the critical density in the alternate models is similar to that of the standard model when they are made to fit the abundances. This reinforces the conclusion that the baryonic density relative to critical density is about 0.06, and also reinforces the need for both nonbaryonic dark matter and dark baryonic matter.

Alternative to Agricultural Drains in California's San Joaquin Valley: Results of a Regional-Scale Hydrogeologic Approach

NASA Astrophysics Data System (ADS)

Belitz, Kenneth; Phillips, Steven P.

1995-08-01

The occurrence of selenium in agricultural drainage water derived from the central part of the western San Joaquin Valley has focused concern on alternatives to agricultural drains for managing shallow, poor-quality groundwater. A transient, three-dimensional simulation model was developed to evaluate the response of the water table to alternatives that affect recharge to or discharge from the groundwater flow system. The modeled area is 551 mi2 (1 mi2 = 2.59 km2) and includes both the semiconfined and confined zones above and below the Corcoran Clay Member of the Tulare Formation of Pleistocene age. The simulation model was calibrated using hydrologic data from 1972 to 1988, and was extended to the year 2040 to forecast for various management alternatives, including maintenance of present practices, land retirement, reduced recharge, increased groundwater pumping, and combinations of these alternatives. Maintenance of present practices results in a worsening of the situation: the total area subject to bare-soil evaporation increases from 224 mi2 in 1990 to 344 mi2 in 2040, and drain flow increases from 25,000 ac ft/yr (1 ac ft = 1234 m3) to 28,000 ac ft/yr. Although land retirement results in elimination of bare-soil evaporation and drain flow in the areas retired, it has little to no effect in adjacent areas. In contrast, regional-scale changes in recharge and pumping are effective for regional management. The area subject to bare-soil evaporation can be reduced to 78 mi2, and drain flow to 8000 ac ft/yr if (1) recharge is reduced by 15% (26,000 ac ft/yr) in areas that currently use surface and groundwater (362 mi2); (2) recharge is reduced by 40% (28,000 ac ft/yr) in areas that currently use only surface water (137 mi2); and (3) pumping rates are uniformly incremented by 0.5 ft/yr (160,000 ac ft/yr) in both areas. If these water budget changes were to be implemented in the study area, and in adjacent areas with similiar Hydrogeologic characteristics, then approximately 400,000 ac ft/yr of surface water would be made available. Thus a shift in the hydrologic budget in the central part of the western San Joaquin Valley improves the prospects for sustaining agriculture in the area, and could provide substantial water resources for other uses.

The Effect of Parenthood Education on Self- Efficacy and Parent Effectiveness in an Alternative High School Student Population

ERIC Educational Resources Information Center

Meyer, Becky Weller; Jain, Sachin; Canfield-Davis, Kathy

2011-01-01

Adolescents defined as at-risk typically lack healthy models of parenting and receive no parenthood education prior to assuming the parenting role. Unless a proactive approach is implemented, the cyclic pattern of dysfunctional parenting-- including higher rates of teen pregnancy, increased childhood abuse, low educational attainment,…

41 CFR 102-80.120 - What analytical and empirical tools should be used to support the life safety equivalency...

Code of Federal Regulations, 2010 CFR

2010-07-01

... used to support the life safety equivalency evaluation? Analytical and empirical tools, including fire models and grading schedules such as the Fire Safety Evaluation System (Alternative Approaches to Life... empirical tools should be used to support the life safety equivalency evaluation? 102-80.120 Section 102-80...

41 CFR 102-80.120 - What analytical and empirical tools should be used to support the life safety equivalency...

Code of Federal Regulations, 2011 CFR

2011-01-01

... used to support the life safety equivalency evaluation? Analytical and empirical tools, including fire models and grading schedules such as the Fire Safety Evaluation System (Alternative Approaches to Life... empirical tools should be used to support the life safety equivalency evaluation? 102-80.120 Section 102-80...

Expanding the Discussion of Faculty Vitality to Include Productive but Disengaged Senior Faculty

ERIC Educational Resources Information Center

Huston, Therese A.; Norman, Marie; Ambrose, Susan A.

2007-01-01

In this essay, the authors begin by examining and challenging the way in which faculty vitality has been operationalized in the past, arguing for the value of institution-specific analysis of the faculty vitality issue. They then propose alternative models for understanding previously unexplored aspects of faculty vitality, drawing on research in…

Students' Understandings of Acid Strength: How Meaningful Is Reliability When Measuring Alternative Conceptions

ERIC Educational Resources Information Center

Bretz, Stacey Lowery; McClary, LaKeisha

2015-01-01

Most organic chemistry reactions occur by a mechanism that includes acid-base chemistry, so it is important that students develop and learn to use correct conceptions of acids and acid strength. Recent studies have described undergraduate organic chemistry students' cognitive resources related to the Brønsted-Lowry acid model and the Lewis acid…

S.P.I.C.E. Workshop Model: An Approach to Alternative Programs for the Disadvantaged Gifted.

ERIC Educational Resources Information Center

Mitchell, Bruce M.; Dodson, Edward

Major problems associated with subcultural variations in school performance that interfere with the development of special programs for disadvantaged, gifted students are discussed. These problems include the difficulty of identifying gifted minority students by usual testing methods, the nature of programs that may be devised to benefit them, and…