Overhauling Technical Handouts for Active Student Participation: A Model for Improving Lecture Efficiency and Increasing Attendance

ERIC Educational Resources Information Center

Jakee, Keith

2011-01-01

This instructional paper is intended to provide an alternative approach to developing lecture materials, including handouts and PowerPoint slides, successfully developed over several years. The principal objective is to aid in the bridging of traditional "chalk and talk" lecture approaches with more active learning techniques, especially in more…

TRANSPORT OF TRICHLOROETHYLENE (TCE) IN NATURAL SOIL BY ELECTROOSMOSIS

EPA Science Inventory

Contamination in low permeability soils poses a significant technical challenge to in-situ remediation, primarily due to low mobilization of the contaminants and difficulty in uniform delivery of treatment reagents. An alternative approach using electroosmosis (EO) is used to mob...

16 CFR 1204.6 - Findings.

Code of Federal Regulations, 2012 CFR

2012-01-01

... directional antennas can obtain greater reception and transmitting capabilities in one or more directions than... manufacturers, including one or two of the major producers, to abandon production of omnidirectional CB base.... (5) The Commission also considered alternative technical approaches to reducing or eliminating...

16 CFR 1204.6 - Findings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... directional antennas can obtain greater reception and transmitting capabilities in one or more directions than... manufacturers, including one or two of the major producers, to abandon production of omnidirectional CB base.... (5) The Commission also considered alternative technical approaches to reducing or eliminating...

16 CFR 1204.6 - Findings.

Code of Federal Regulations, 2014 CFR

2014-01-01

... directional antennas can obtain greater reception and transmitting capabilities in one or more directions than... manufacturers, including one or two of the major producers, to abandon production of omnidirectional CB base.... (5) The Commission also considered alternative technical approaches to reducing or eliminating...

16 CFR 1204.6 - Findings.

Code of Federal Regulations, 2011 CFR

2011-01-01

... directional antennas can obtain greater reception and transmitting capabilities in one or more directions than... manufacturers, including one or two of the major producers, to abandon production of omnidirectional CB base.... (5) The Commission also considered alternative technical approaches to reducing or eliminating...

Qualification Procedures for VHSIC/VLSI

DTIC Science & Technology

1990-12-01

alternative approach for qualification of complex microcircuits. To address the technical issues related to a process oriented qualification approach, the...methodology of microcircuit process control to promote the United States to a position of supplying the nighest quality and most reliable...available resources . o Coordinate document reviews with weekly and monthly status reviews on progress. o Summarize results and collate into four basic

An Alternative Expert Knowledge Transfer Model: A Case Study of an Indigenous Storytelling Approach

ERIC Educational Resources Information Center

Spaulding, Roderick Jay

2010-01-01

The increasing complexity of technical work, the demand for highly skilled workers, and the vital challenges facing the world at large have combined to create a need for better ways to transfer knowledge, especially expert knowledge. In this dissertation, I attempted to see if an approach to this process that is more holistic than is typical in…

Republic of the Marshall Islands. Energy Project Development Options and Technical Assessment (2013)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conrad, Misty Dawn; Olis, Dan; Ness, J. Erik

2015-09-01

The advancement of renewable energy and energy efficient technologies continues to be fluid. There are many technical opportunities and strategies that can be utilized to guide communities to deploy cost-effective commercial alternative energy options; however, to achieve aggressive economic, environmental, and security goals, it requires a comprehensive, integrated approach. This document reports on the initial findings of an energy assessment that was conducted for the Republic of the Marshall Islands.

Future space transportation systems systems analysis study, phase 1 technical report

NASA Technical Reports Server (NTRS)

1975-01-01

The requirements of projected space programs (1985-1995) for transportation vehicles more advanced than the space shuttle are discussed. Several future program options are described and their transportation needs are analyzed. Alternative systems approaches to meeting these needs are presented.

Integrating Exposure into Chemical Alternatives Assessment ...

EPA Pesticide Factsheets

Most alternatives assessments (AA) published to date are largely hazard-based rankings, and as such may not represent a fully informed consideration of the advantages and disadvantages of possible alternatives. With an assessment goal of identifying an alternative chemical that is more sustainable, other attributes beyond hazard are also important, including exposure, risk, life-cycle impacts, performance, cost, and social responsibility. Building on the 2014 recommendations by the U.S. National Academy of Sciences to improve AA decisions by including comparative exposure assessment, the HESISustainable Chemical Alternatives Technical Committee, which consists of scientists from academia, industry, government, and NGOs, has developed a qualitative comparative exposure approach. Conducting such a comparison can screen for alternatives that are expected to have a higher exposure potential, which could trigger a higher-tiered, more quantitative exposure assessment on the alternatives being considered. This talk will demonstrate an approach for including chemical- and product-related exposure information in a qualitative AA comparison. Starting from existing hazard AAs, a series of four chemical-product application scenarios were examined to test the concept, to understand the effort required, and to determine the value of exposure data in AA decision-making. The group has developed a classification approach for ingredient and product parameters to support compariso

Alternative Endpoints and Approaches Selected for the Remediation of Contaminated Groundwater at Complex Sites

NASA Astrophysics Data System (ADS)

Deeb, R. A.; Hawley, E.

2011-12-01

This presentation will focus on findings, statistics, and case studies from a recently-completed report for the Department of Defense's Environmental Security Technology Certification Program (ESTCP) (Project ER-0832) on alternative endpoints and alternative remedial strategies for groundwater remediation under a variety of Federal and state cleanup programs, including technical impracticability (TI) and other Applicable or Relevant and Appropriate Requirement (ARAR) waivers, state and local designations such as groundwater management zones, Alternate Concentration Limits (ACLs), use of monitored natural attenuation (MNA) over long timeframes, and more. The primary objective of the project was to provide environmental managers and regulators with tools, metrics, and information needed to evaluate alternative endpoints for groundwater remediation at complex sites. A statistical analysis of Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) sites receiving TI waivers will be presented as well as case studies of other types of alternative endpoints and alternative remedial strategies to illustrate the variety of approaches used at complex sites and the technical analyses used to predict and document cost, timeframe, and potential remedial effectiveness. Case studies provide examples of the flexible, site-specific, application of alternative endpoints and alternative remedial strategies that have been used in the past to manage and remediate groundwater contamination at complex sites. For example, at least 13 states consider some designation for groundwater containment in their corrective action policies, such as groundwater management zones, containment zones, and groundwater classification exemption areas. These designations typically indicate that groundwater contamination is present above permissible levels. Soil and groundwater within these zones are managed to protect human health and the environment. Lesson learned for the analyses conducted and the case studies evaluated allow for a more careful consideration of alternative, beneficial, and cost-effective cleanup objectives and metrics that can be achieved over the short-term (while eventually meeting long-term cleanup objectives or demonstrating the applicability of alternative endpoints), thus improving the site cleanup process at complex sites where appropriate.

Fault detection techniques for complex cable shield topologies

NASA Astrophysics Data System (ADS)

Coonrod, Kurt H.; Davis, Stuart L.; McLemore, Donald P.

1994-09-01

This document presents the results of a basic principles study which investigated technical approaches for developing fault detection techniques for use on cables with complex shielding topologies. The study was limited to those approaches which could realistically be implemented on a fielded cable, i.e., approaches which would require partial disassembly of a cable were not pursued. The general approach used was to start with present transfer impedance measurement techniques and modify their use to achieve the best possible measurement range. An alternative test approach, similar to a sniffer type test, was also investigated.

A technical guide to tDCS, and related non-invasive brain stimulation tools

PubMed Central

Woods, AJ; Antal, A; Bikson, M; Boggio, PS; Brunoni, AR; Celnik, P; Cohen, LG; Fregni, F; Herrmann, CS; Kappenman, ES; Knotkova, H; Liebetanz, D; Miniussi, C; Miranda, PC; Paulus, W; Priori, A; Reato, D; Stagg, C; Wenderoth, N; Nitsche, MA

2015-01-01

Transcranial electrical stimulation (tES), including transcranial direct and alternating current stimulation (tDCS, tACS) are non-invasive brain stimulation techniques increasingly used for modulation of central nervous system excitability in humans. Here we address methodological issues required for tES application. This review covers technical aspects of tES, as well as applications like exploration of brain physiology, modelling approaches, tES in cognitive neurosciences, and interventional approaches. It aims to help the reader to appropriately design and conduct studies involving these brain stimulation techniques, understand limitations and avoid shortcomings, which might hamper the scientific rigor and potential applications in the clinical domain. PMID:26652115

Technical Note [cmUse of a Snare Wire to Perform Nephrostomy Access in the Presence of Obstructive Staghorn Calculi

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nosher, John L.; Siegel, Randall L.; Bodner, Leonard J.

1996-05-15

We describe a technique for gaining access to the central collecting system via a chosen calyx, utilizing an alternative entry point to that calyx. An Amplatz nitinol loop snare is then used to convert this access to a traditional approach.

A Plan For a Publication Network For Rapid Dissemination of Technical Information.

ERIC Educational Resources Information Center

MacLachlan, James

This paper describes an alternative to current information dissemination systems (letter journals), computerized information systems, and clearinghouse operations) that would establish a network of depositories at universities and research organizations. The essence of the approach is to provide convenient access to working papers and technical…

Getting Limits off the Ground via Sequences

ERIC Educational Resources Information Center

Gass, Frederick

2006-01-01

Most beginning calculus courses spend little or no time on a technical definition of the limit concept. In most of the remaining courses, the definition presented is the traditional epsilon-delta definition. An alternative approach that bases the definition on infinite sequences has occasionally appeared in commercial textbooks but has not yet…

Innovative Concepts and Technology for Railroad-Highway Grade Crossing Motorist Warning Systems : Volume 2. The Generation and Analysis of Alternative Concepts

DOT National Transportation Integrated Search

1977-09-01

The report describes the results of a study directed toward the generation, analysis and evaluation of innovative conceptual and technical approaches to train-activated motorist warning systems for use at railroad-highway grade crossings. Particular ...

How To Improve Work In Planetarium?

NASA Astrophysics Data System (ADS)

Pavicic, G.

2009-09-01

Planetariums can provide an immersive environment for scientific education, virtual reality, and entertainment (Shaw 1998). Digital projection into domes, called "full dome projection", can be a technically challenging and expensive exercise, particularly for installation with a modest budget. Here we present an alternative full dome digital projection system, which consists of a single projector and a spherical mirror that scatter the light onto the dome surface. This approach offers many advantages over the fisheye lens alternatives, and results in a similar quality for just a fraction of costs.

ARPA/NRL X-Ray Laser Program - Semiannual Technical Report to Defense Advanced Research Projects Agency, 1 January 1975-30 June 1975

DTIC Science & Technology

1975-09-01

being conducted with highly- stripped carbon ions emitted fron a laser -irradiated surface and ^xpandin- into a background gas . The...obtained from reported measurement s of noble gas lasers indicate that the amplifiers will operate in I depletion mode, providing pulse powers in the...pumping appears to be the easier alternative and it will be pursued. The alternative amplifier approach involving electron beam pumped noble gas lasers

Endoscopic and keyhole endoscope-assisted neurosurgical approaches: a qualitative survey on technical challenges and technological solutions.

PubMed

Marcus, Hani J; Cundy, Thomas P; Hughes-Hallett, Archie; Yang, Guang-Zhong; Darzi, Ara; Nandi, Dipankar

2014-10-01

The literature reflects a resurgence of interest in endoscopic and keyhole endoscope-assisted neurosurgical approaches as alternatives to conventional microsurgical approaches in carefully selected cases. The aim of this study was to assess the technical challenges of neuroendoscopy, and the scope for technological innovations to overcome these barriers. All full members of the Society of British Neurosurgeons (SBNS) were electronically invited to participate in an online survey. The open-ended structured survey asked three questions; firstly, whether the surgeon presently utilises or has experience with endoscopic or endoscope-assisted approaches; secondly, what they consider to be the major technical barriers to adopting such approaches; and thirdly, what technological advances they foresee improving safety and efficacy in the field. Responses were subjected to a qualitative research method of multi-rater emergent theme analysis. Three clear themes emerged: 1) surgical approach and better integration with image-guidance systems (20%), 2) intra-operative visualisation and improvements in neuroendoscopy (49%), and 3) surgical manipulation and improvements in instruments (74%). The analysis of responses to our open-ended survey revealed that although opinion was varied three major themes could be identified. Emerging technological advances such as augmented reality, high-definition stereo-endoscopy, and robotic joint-wristed instruments may help overcome the technical difficulties associated with neuroendoscopic approaches. Results of this qualitative survey provide consensus amongst the technology end-user community such that unambiguous goals and priorities may be defined. Systems integrating these advances could improve the safety and efficacy of endoscopic and endoscope-assisted neurosurgical approaches.

Endoscopic and Keyhole Endoscope-assisted Neurosurgical Approaches: A Qualitative Survey on Technical Challenges and Technological Solutions

PubMed Central

Marcus, Hani J; Cundy, Thomas P; Hughes-Hallett, Archie; Yang, Guang-Zhong; Darzi, Ara; Nandi, Dipankar

2014-01-01

Introduction The literature reflects a resurgence of interest in endoscopic and keyhole endoscope-assisted neurosurgical approaches as alternatives to conventional microsurgical approaches in carefully selected cases. The aim of this study was to assess the technical challenges of neuroendoscopy, and the scope for technological innovations to overcome these barriers. Materials and Methods All full members of the Society of British Neurosurgeons (SBNS) were electronically invited to participate in an online survey. The open-ended structured survey asked three questions; firstly, whether the surgeon presently utilises or has experience with endoscopic or endoscope-assisted approaches; secondly, what they consider to be the major technical barriers to adopting such approaches; and thirdly, what technological advances they foresee improving safety and efficacy in the field. Responses were subjected to a qualitative research method of multi-rater emergent themes analysis. Results Three clear themes emerged: 1) surgical approach and better integration with image-guidance systems (20%), 2) intra-operative visualisation and improvements in neuroendoscopy (49%), and 3) surgical manipulation and improvements in instruments (74%). Discussion The analysis of responses to our open-ended survey revealed that although opinion was varied three major themes could be identified. Emerging technological advances such as augmented reality, high-definition stereo-endoscopy, and robotic joint-wristed instruments may help overcome the technical difficulties associated with neuroendoscopic approaches. Conclusions Results of this qualitative survey provide consensus amongst the technology end-user community such that unambiguous goals and priorities may be defined. Systems integrating these advances could improve the safety and efficacy of endoscopic and endoscope-assisted neurosurgical approaches. PMID:24533591

Glossary of reference terms for alternative test methods and their validation.

PubMed

Ferrario, Daniele; Brustio, Roberta; Hartung, Thomas

2014-01-01

This glossary was developed to provide technical references to support work in the field of the alternatives to animal testing. It was compiled from various existing reference documents coming from different sources and is meant to be a point of reference on alternatives to animal testing. Giving the ever-increasing number of alternative test methods and approaches being developed over the last decades, a combination, revision, and harmonization of earlier published collections of terms used in the validation of such methods is required. The need to update previous glossary efforts came from the acknowledgement that new words have emerged with the development of new approaches, while others have become obsolete, and the meaning of some terms has partially changed over time. With this glossary we intend to provide guidance on issues related to the validation of new or updated testing methods consistent with current approaches. Moreover, because of new developments and technologies, a glossary needs to be a living, constantly updated document. An Internet-based version based on this compilation may be found at http://altweb.jhsph.edu/, allowing the addition of new material.

Percutaneous endoscopic lumbar discectomy via contralateral approach: a technical case report.

PubMed

Kim, Jin-Sung; Choi, Gun; Lee, Sang-Ho

2011-08-01

Technical case report. The authors report a new percutaneous endoscopic lumbar discectomy (PELD) technique for the treatment of lumbar disc herniation via a contralateral approach. When there are highly down-migrated lumbar disc herniation along just medial to pedicle and narrow ipsilateral intervertebral foramen, the conventional PELD is not easily accessible via ipsilateral transforaminal route. Five patients manifested gluteal and leg pain because of a soft disc herniation at the L4-L5 level. Transforaminal PELD via a contralateral approach was performed to remove the herniated fragment, achieving complete decompression of the nerve root. The symptom was relieved and the patient was discharged the next day. When a conventional transforaminal PELD is difficult because of some anatomical reasons, PELD via a contralateral route could be a good alternative option in selected cases.

Fiscal year 1980-81 implementation plan in support of technical development and integration of sampling and aggregation procedures. [crop acreage estimation

NASA Technical Reports Server (NTRS)

1981-01-01

The specific objectives of the FY 1980-81 tasks are: (1) further refinements to the weighted aggregation procedure; (2) improved approaches for estimating within-stratum variance; (3) more intensive investigation of alternative sampling strategies such as full-frame sampling strategy, and (4) further developments in regard to a simulated approach for assessing the performance of the overall designed sampling and aggregation system.

Exploration studies technical report, FY1988 status. Volume 1: Technical summary

NASA Technical Reports Server (NTRS)

1988-01-01

The Office of Exploration (OEXP) at NASA Headquarters has been tasked with defining and recommending alternatives for an early 1990's nationaL decision on a focused program of human exploration of the solar system. The Mission Analysis and System Engineering (MASE) group, which is managed by the Exploration Studies Office at the Lyndon B. Johnson Space Center, is responsible for coordinating the technical studies necessary for accomplishing such a task. This technical report, produced by the MASE, describes the process that has been developed in a case study approach. The four case studies developed in FY88 include: (1) Human Expedition to Phobos; (2) Human Expedition to Mars; (3) Lunar Observatory; and (4) Lunar Outpost to Early Mars Evolution. The final outcome of this effort is a set of programmatic and technical conclusions and recommendations for the following year's work.

How to Determine the Quality of Students' Reflections?

ERIC Educational Resources Information Center

Leijen, Ali; Valtna, Kai; Leijen, Djuddah A. J.; Pedaste, Margus

2012-01-01

This article discusses some of the ambiguities related to the concept of reflection in education, and presents an alternative approach for determining the focus and quality of students' reflection. Accordingly, the focus of reflection can vary from a concrete technical aspect of an experience to the broader societal context of that experience, and…

An Approach for Casual Drug Users. Technical Paper.

ERIC Educational Resources Information Center

Bloom, Erwin S., Ed.

This publication was written to respond to the fact that many drug treatment centers receive inappropriate referrals of casual or recreational marihuana users from the courts for "treatment" as an alternative to jail. A drug abuse task force recommended that agencies give priority to abusers of the high-risk categories and to compulsive users of…

VOCATIONAL-TECHNICAL TEACHER EDUCATION--NATIONAL SEMINAR PROCEEDINGS (SEPTEMBER 24-29, 1967). LEADERSHIP 15.

ERIC Educational Resources Information Center

VIVIAN, NEAL E.; HOFFMAN, KENNETH E.

APPROXIMATELY 300 TEACHER-EDUCATORS AND NATIONAL LEADERS AND EXPERTS IN EDUCATION AND RELATED DISCIPLINES FROM 46 STATES, TWO TERRITORIES, AND TWO CANADIAN PROVINCES PARTICIPATED IN A SEMINAR TO IDENTIFY ALTERNATIVE APPROACHES FOR IMPROVING PROGRAMS IN PREPARING AND UPGRADING VOCATIONAL TEACHERS. MAJOR SPEECHES INCLUDED--(1) "URGENCY OF THE DEMAND…

Implementing and Assessing the Converging-Diverging Model of Design in a Sequence of Sophomore Projects

ERIC Educational Resources Information Center

Dahm, Kevin; Riddell, William; Constans, Eric; Courtney, Jennifer; Harvey, Roberta; Von Lockette, Paris

2009-01-01

This paper discusses a sophomore-level course that teaches engineering design and technical writing. Historically, the course was taught using semester-long design projects. Most students' overall approach to design problems left considerable room for improvement. Many teams chose a design without investigating alternatives, and important…

Vocational-Technical Physics Project. Instructor's Manual. Field Test Edition.

ERIC Educational Resources Information Center

Forsyth Technical Inst., Winston-Salem, NC.

This instructor's manual in vocational physics consists of five modules: Jacks, Thermometers, The Alternator, The Pool Table, and The Radiator. It is an individualized approach, designed for use with accompanying student manuals on each of the individual modules. Each module in the instructor's manual consists of a general description plus an…

An Alternative Approach to Identifying Students with Learning Disabilities in Australian Schools

ERIC Educational Resources Information Center

Skues, Jason L.; Cunningham, Everarda G.

2013-01-01

This study examined the validity of using teacher-administered educational and intelligence tests to screen students for learning disabilities (LDs). Twenty-seven Technical and Further Education (TAFE) students from regional Victoria who were enrolled in a program that was designed to reconnect school dropouts with education via TAFE participated…

A technical guide to tDCS, and related non-invasive brain stimulation tools.

PubMed

Woods, A J; Antal, A; Bikson, M; Boggio, P S; Brunoni, A R; Celnik, P; Cohen, L G; Fregni, F; Herrmann, C S; Kappenman, E S; Knotkova, H; Liebetanz, D; Miniussi, C; Miranda, P C; Paulus, W; Priori, A; Reato, D; Stagg, C; Wenderoth, N; Nitsche, M A

2016-02-01

Transcranial electrical stimulation (tES), including transcranial direct and alternating current stimulation (tDCS, tACS) are non-invasive brain stimulation techniques increasingly used for modulation of central nervous system excitability in humans. Here we address methodological issues required for tES application. This review covers technical aspects of tES, as well as applications like exploration of brain physiology, modelling approaches, tES in cognitive neurosciences, and interventional approaches. It aims to help the reader to appropriately design and conduct studies involving these brain stimulation techniques, understand limitations and avoid shortcomings, which might hamper the scientific rigor and potential applications in the clinical domain. Copyright © 2015 International Federation of Clinical Neurophysiology. All rights reserved.

Automated array assembly task, phase 1

NASA Technical Reports Server (NTRS)

Carbajal, B. G.

1977-01-01

An assessment of state-of-the-art technologies that are applicable to silicon solar cell and solar cell module fabrication is provided. The assessment consists of a technical feasibility evaluation and a cost projection for high-volume production of silicon solar cell modules. The cost projection was approached from two directions; a design-to-cost analysis assigned cost goals to each major process element in the fabrication scheme, and a cost analysis built up projected costs for alternate technologies for each process element. A technical evaluation was used in combination with the cost analysis to identify a baseline low cost process. A novel approach to metal pattern design based on minimum power loss was developed. These design equations were used as a tool in the evaluation of metallization technologies.

Commercial Building Energy Asset Score System: Program Overview and Technical Protocol (Version 1.0)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Na; Gorrissen, Willy J.

2013-01-11

The U.S. Department of Energy (DOE) is developing a national voluntary energy asset score system that includes an energy asset score tool to help building owners evaluate their buildings with respect to the score system. The goal of the energy asset score system is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system will allow building owners and managers to compare their building infrastructure against peers and track building upgrade progress over time. The system can also help other building stakeholders (e.g., building operators, tenants, financiers, and appraisers) understand the relative efficiency of different buildings inmore » a way that is independent from their operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset score tool. This report also describes alternative methods that were considered prior to developing the current approach. Finally, this report describes a few features of the program where alternative approaches are still under evaluation.« less

Technical approach to groundwater restoration. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-11-01

The Technical Approach to Groundwater Restoration (TAGR) provides general technical guidance to implement the groundwater restoration phase of the Uranium Mill Tailings Remedial Action (UMTRA) Project. The TAGR includes a brief overview of the surface remediation and groundwater restoration phases of the UMTRA Project and describes the regulatory requirements, the National Environmental Policy Act (NEPA) process, and regulatory compliance. A section on program strategy discusses program optimization, the role of risk assessment, the observational approach, strategies for meeting groundwater cleanup standards, and remedial action decision-making. A section on data requirements for groundwater restoration evaluates the data quality objectives (DQO) andmore » minimum data required to implement the options and comply with the standards. A section on sits implementation explores the development of a conceptual site model, approaches to site characterization, development of remedial action alternatives, selection of the groundwater restoration method, and remedial design and implementation in the context of site-specific documentation in the site observational work plan (SOWP) and the remedial action plan (RAP). Finally, the TAGR elaborates on groundwater monitoring necessary to evaluate compliance with the groundwater cleanup standards and protection of human health and the environment, and outlines licensing procedures.« less

Minilaparoscopic hysterectomy made easy: first report on alternative instrumentation and new integrated energy platform.

PubMed

Ng, Ying Woo; Lim, Li Min; Fong, Yoke Fai

2014-05-01

Minilaparoscopy is an attractive approach for hysterectomy due to advantages such as reduced morbidities and enhanced cosmesis. However, it has not been popularized due to the lack of suitable instruments and high technical demand. We aim to highlight the first case of minilaparoscopic hysterectomy reported in Asia and the use of a new integrated energy platform, Thunderbeat. We would like to propose an alternative method of instrumentation, so as to improve the feasibility and safety of minilaparoscopic hysterectomy. The first minilaparoscopic hysterectomy in Singapore was successfully completed using the alternative instrumentation and new energy platform. There was no conversion or complication during the surgery. The patient recovered uneventfully. To our knowledge, this is the first report on the use of such alternative instrumentation. This approach in instrumentation and the new energy platform will improve the feasibility and speed of the surgery and ensure safety in our patients. © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

Economic Evaluation of Munitions Manufacturing Pink Wastewater Treatment Alternatives Using a Present Value-Unit Cost Methodology

DTIC Science & Technology

1982-02-01

BACKGROUND 1 1.2 TECHNICAL APPROACH 3 1.3 OBJECTIVES 3 2.0 INVESTIGATION 5 2.1 LITERATURE SEARCH 5 2.2 SITE ViSITS 6 2.3 PINK WATER SOURCES AND...Scale 10 5 and 106 GPD Plant Designs 13 3.1 Matrix of Pink Water Treatment Systems Compared on a PVUC Basis 28 3.2 Calculated Capital & Annual... 5 Year Planning Horizon 109 3.6 Calculated PVUC ($/K-GAL) for Each Alternative - 1,000,000 GPD - 5 Year Planning Horizon 110 3.7 Calculated Annual

Equity and efficiency in HIV-treatment in South Africa: the contribution of mathematical programming to priority setting.

PubMed

Cleary, Susan; Mooney, Gavin; McIntyre, Di

2010-10-01

The HIV-epidemic is one of the greatest public health crises to face South Africa. A health care response to the treatment needs of HIV-positive people is a prime example of the desirability of an economic, rational approach to resource allocation in the face of scarcity. Despite this, almost no input based on economic analysis is currently used in national strategic planning. While cost-utility analysis is theoretically able to establish technical efficiency, in practice this is accomplished by comparing an intervention's ICER to a threshold level representing society's maximum willingness to pay to avoid death and improve health-related quality of life. Such an approach has been criticised for a number of reasons, including that it is inconsistent with a fixed budget for health care and that equity is not taken into account. It is also impractical if no national policy on the threshold exists. As an alternative, this paper proposes a mathematical programming approach that is capable of highlighting technical efficiency, equity, the equity/efficiency trade-off and the affordability of alternative HIV-treatment interventions. Government could use this information to plan an HIV-treatment strategy that best meets equity and efficiency objectives within budget constraints.

Optimization of wastewater treatment alternative selection by hierarchy grey relational analysis.

PubMed

Zeng, Guangming; Jiang, Ru; Huang, Guohe; Xu, Min; Li, Jianbing

2007-01-01

This paper describes an innovative systematic approach, namely hierarchy grey relational analysis for optimal selection of wastewater treatment alternatives, based on the application of analytic hierarchy process (AHP) and grey relational analysis (GRA). It can be applied for complicated multicriteria decision-making to obtain scientific and reasonable results. The effectiveness of this approach was verified through a real case study. Four wastewater treatment alternatives (A(2)/O, triple oxidation ditch, anaerobic single oxidation ditch and SBR) were evaluated and compared against multiple economic, technical and administrative performance criteria, including capital cost, operation and maintenance (O and M) cost, land area, removal of nitrogenous and phosphorous pollutants, sludge disposal effect, stability of plant operation, maturity of technology and professional skills required for O and M. The result illustrated that the anaerobic single oxidation ditch was the optimal scheme and would obtain the maximum general benefits for the wastewater treatment plant to be constructed.

A study of space station needs, attributes and architectural options, volume 2, technical. Book 3: Economic benefits, costs and programmatics

NASA Technical Reports Server (NTRS)

1983-01-01

The economic benefits, cost analysis, and industrial uses of the manned space station are investigated. Mission payload costs are examined in relation to alternative architectures and projected technological evolution. Various approaches to industrial involvement for financing, development, and marketing of space station resources are described.

Postoptimality analysis in the selection of technology portfolios

NASA Technical Reports Server (NTRS)

Adumitroaie, Virgil; Shelton, Kacie; Elfes, Alberto; Weisbin, Charles R.

2006-01-01

This paper describes an approach for qualifying optimal technology portfolios obtained with a multi-attribute decision support system. The goal is twofold: to gauge the degree of confidence in the optimal solution and to provide the decision-maker with an array of viable selection alternatives, which take into account input uncertainties and possibly satisfy non-technical constraints.

25 CFR 30.110 - What is the process for requesting technical assistance to develop an alternative definition of AYP?

Code of Federal Regulations, 2011 CFR

2011-04-01

..., DEPARTMENT OF THE INTERIOR EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.110 What is the process for requesting technical assistance to develop an alternative... 25 Indians 1 2011-04-01 2011-04-01 false What is the process for requesting technical assistance...

25 CFR 30.110 - What is the process for requesting technical assistance to develop an alternative definition of AYP?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What is the process for requesting technical assistance..., DEPARTMENT OF THE INTERIOR EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.110 What is the process for requesting technical assistance to develop an alternative...

Technical Review of the CENWP Computational Fluid Dynamics Model of the John Day Dam Forebay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rakowski, Cynthia L.; Serkowski, John A.; Richmond, Marshall C.

The US Army Corps of Engineers Portland District (CENWP) has developed a computational fluid dynamics (CFD) model of the John Day forebay on the Columbia River to aid in the development and design of alternatives to improve juvenile salmon passage at the John Day Project. At the request of CENWP, Pacific Northwest National Laboratory (PNNL) Hydrology Group has conducted a technical review of CENWP's CFD model run in CFD solver software, STAR-CD. PNNL has extensive experience developing and applying 3D CFD models run in STAR-CD for Columbia River hydroelectric projects. The John Day forebay model developed by CENWP is adequatelymore » configured and validated. The model is ready for use simulating forebay hydraulics for structural and operational alternatives. The approach and method are sound, however CENWP has identified some improvements that need to be made for future models and for modifications to this existing model.« less

Measuring Efficiency of Health Systems of the Middle East and North Africa (MENA) Region Using Stochastic Frontier Analysis.

PubMed

Hamidi, Samer; Akinci, Fevzi

2016-06-01

The main purpose of this study is to measure the technical efficiency of twenty health systems in the Middle East and North Africa (MENA) region to inform evidence-based health policy decisions. In addition, the effects of alternative stochastic frontier model specification on the empirical results are examined. We conducted a stochastic frontier analysis to estimate the country-level technical efficiencies using secondary panel data for 20 MENA countries for the period of 1995-2012 from the World Bank database. We also tested the effect of alternative frontier model specification using three random-effects approaches: a time-invariant model where efficiency effects are assumed to be static with regard to time, and a time-varying efficiency model where efficiency effects have temporal variation, and one model to account for heterogeneity. The average estimated technical inefficiency of health systems in the MENA region was 6.9 % with a range of 5.7-7.9 % across the three models. Among the top performers, Lebanon, Qatar, and Morocco are ranked consistently high according to the three different inefficiency model specifications. On the opposite side, Sudan, Yemen and Djibouti ranked among the worst performers. On average, the two most technically efficient countries were Qatar and Lebanon. We found that the estimated technical efficiency scores vary substantially across alternative parametric models. Based on the findings reported in this study, most MENA countries appear to be operating, on average, with a reasonably high degree of technical efficiency compared with other countries in the region. However, there is evidence to suggest that there are considerable efficiency gains yet to be made by some MENA countries. Additional empirical research is needed to inform future health policies aimed at improving both the efficiency and sustainability of the health systems in the MENA region.

Implementing assessments of robot-assisted technical skill in urological education: a systematic review and synthesis of the validity evidence.

PubMed

Goldenberg, Mitchell G; Lee, Jason Y; Kwong, Jethro C C; Grantcharov, Teodor P; Costello, Anthony

2018-03-31

To systematically review and synthesise the validity evidence supporting intraoperative and simulation-based assessments of technical skill in urological robot-assisted surgery (RAS), and make evidence-based recommendations for the implementation of these assessments in urological training. A literature search of the Medline, PsycINFO and Embase databases was performed. Articles using technical skill and simulation-based assessments in RAS were abstracted. Only studies involving urology trainees or faculty were included in the final analysis. Multiple tools for the assessment of technical robotic skill have been published, with mixed sources of validity evidence to support their use. These evaluations have been used in both the ex vivo and in vivo settings. Performance evaluations range from global rating scales to psychometrics, and assessments are carried out through automation, expert analysts, and crowdsourcing. There have been rapid expansions in approaches to RAS technical skills assessment, both in simulated and clinical settings. Alternative approaches to assessment in RAS, such as crowdsourcing and psychometrics, remain under investigation. Evidence to support the use of these metrics in high-stakes decisions is likely insufficient at present. © 2018 The Authors BJU International © 2018 BJU International Published by John Wiley & Sons Ltd.

OEXP exploration studies technical report. Volume 3: Special reports, studies, and indepth systems assessments

NASA Technical Reports Server (NTRS)

Roberts, Barney B.; Bland, Dan

1988-01-01

The Office of Exploration (OEXP) at NASA has been tasked with defining and recommending alternatives for an early 1990's national decision on a focused program of manned exploration of the Solar System. The Mission analysis and System Engineering (MASE) group, which is managed by the Exploration Studies Office at the Johnson Space Center, is responsible for coordinating the technical studies necessary for accomplishing such a task. This technical report, produced by the MASE, describes the process used to conduct exploration studies and discusses the mission developed in a case study approach. The four case studies developed in FY88 include: (1) a manned expedition to PHOBOS; (2) a manned expedition to MARS; (3) a lunar surface observatory; and a lunar outpost to early Mars evolution. The final outcome of this effort is a set of programmatic and technical conclusions and recommendations for the following year's work.

The Comparative Instructional Effectiveness of Print-Based and Video-Based Instructional Materials for Teaching Practical Skills at a Distance

ERIC Educational Resources Information Center

Donkor, Francis

2010-01-01

Print-based instructional materials have been more popular than any other medium for teaching practical skills during the delivery of technical and vocational education and training via distance learning. However, the approach has its shortcomings and in recent times alternatives have been sought. The comparative instructional effectiveness of one…

Nursing Practice Should Be Informed by the Best Available Evidence, but Should All First-Level Nurses Be Competent at Research Appraisal and Utilization?

ERIC Educational Resources Information Center

White, Robert; Taylor, Shirley

2002-01-01

The British model of nurses as finders, appraisers, and users of research in practice is unattainable, given the technical complexity of research and the skills and time required. Clinical governance mechanisms and accountability demands further undermine the approach. An alternative is development of nursing research specialists and…

Multiple Analogies for Complex Concepts: Antidotes for Analogy-Induced Misconception in Advanced Knowledge Acquisition. Technical Report No. 439.

ERIC Educational Resources Information Center

Spiro, Rand J.; And Others

This report argues that there exists a pervasive tendency for analogies to contribute to the development of entrenched misconceptions in the form of reducing complex new knowledge to the core of a source analogy. The report presents a taxonomy of ways that simple analogy induces conceptual error and an alternative approach involving integrated…

Computational Approaches for Analyzing Tradeoffs between Training and Aiding. Final Technical Paper for Period February-December 1989.

ERIC Educational Resources Information Center

Rouse, William B.; Johnson, William B.

A methodological framework is presented for representing tradeoffs among alternative combinations of training and aiding for personnel in complex situations. In general, more highly trained people need less aid, and those with less training need more aid. Balancing training and aiding to accomplish the objectives of the system in a cost effective…

Using Artifacts to Characterize Reform-Oriented Instruction: The Scoop Notebook and Rating Guide. CSE Technical Report 707

ERIC Educational Resources Information Center

Borko, Hilda; Stecher, Brian; Kuffner, Karin

2007-01-01

This document includes the final data collection and scoring tools created by the "Scoop" project, a five-year project funded through the Center for Evaluation, Standards,and Student Testing (CRESST), to develop an alternative approach for characterizing classroom practice. The goal of the project was to use artifacts and related materials to…

Satellite power system concept development and evaluation program. Volume 1: Technical assessment summary report

NASA Technical Reports Server (NTRS)

1980-01-01

Candidate satellite power system (SPS) concepts were identified and evaluated in terms of technical and cost factors. A number of alternative technically feasible approaches and system concepts were investigated. A reference system was defined to facilitate economic, environmental, and societal assessments by the Department of Energy. All elements of the reference system were defined including the satellite and all its subsystems, the orbital construction and maintenance bases, all elements of the space transportation system, the ground receiving station, and the associated industrial facilities for manufacturing the required hardware. The reference conclusions and remaining issues are stated for the following topical areas: system definition; energy conversion and power management; power transmission and reception; structures, controls, and materials; construction and operations; and space transportation.

Perihilar Glissonian Approach for Anatomical Parenchymal Sparing Liver Resections: Technical Aspects: The Taping Game.

PubMed

Figueroa, Rodrigo; Laurenzi, Andrea; Laurent, Alexis; Cherqui, Daniel

2018-03-01

To present technical details for central hepatectomy and right anterior and posterior sectionectomies using perihilar Glissonian approach for anatomical delineation and selective inflow occlusion. Central tumors and those deeply located in the right liver may require extensive resections because of their proximity to major vascular structures. In such cases, anatomical more limited resections such as central hepatectomy or sectionectomies may provide an alternative to extensive surgery by assuring both parenchymal sparing and suitable oncologic resection. We present the global concept for performing a perihilar Glissonian approach and its application to each individual anatomical procedure. This includes detailed descriptions, illustrations, and videos demonstrating the technique. This technique was applied since 1991 for anatomical parenchymal resections including central hepatectomy (resection of segments 4, 5, and 8), right anterior sectionectomy (resection of segments 5 and 8), and right posterior sectionectomy (resection of segments 6 and 7). The feasibility rate of the Glissonian approach was 88%. Perihilar Glissonian approach is a safe and reproducible technique that enables anatomical parenchymal preserving liver resections for selected central and right-sided deeply located tumors.

Degenerative Pannus Mimicking Clival Chordoma Resected via an Endoscopic Transnasal Approach.

PubMed

Khaldi, Ahmad; Griauzde, Julius; Duckworth, Edward A M

2011-05-01

Lesions of the lower clivus represent a technically challenging subset of skull base disease that requires careful treatment. A 75-year-old woman with tongue atrophy was referred for resection of a presumed clival chordoma. The lesion was resected via an endoscopic transnasal transclival approach with no complications. Pathology revealed only chronic inflammatory tissue consistent with a degenerative pannus. Degenerative pannus should be included in the differential diagnosis of lower clival extradural lesions. The endoscopic transnasal transclival corridor should be considered for resection of such lesions as an alternative to larger, more morbid, traditional skull base approaches.

Degenerative Pannus Mimicking Clival Chordoma Resected via an Endoscopic Transnasal Approach

PubMed Central

Khaldi, Ahmad; Griauzde, Julius; Duckworth, Edward A.M.

2011-01-01

Lesions of the lower clivus represent a technically challenging subset of skull base disease that requires careful treatment. A 75-year-old woman with tongue atrophy was referred for resection of a presumed clival chordoma. The lesion was resected via an endoscopic transnasal transclival approach with no complications. Pathology revealed only chronic inflammatory tissue consistent with a degenerative pannus. Degenerative pannus should be included in the differential diagnosis of lower clival extradural lesions. The endoscopic transnasal transclival corridor should be considered for resection of such lesions as an alternative to larger, more morbid, traditional skull base approaches. PMID:23984195

Low-carbon yak cheese: transition to biogas in a Himalayan socio-technical niche

PubMed Central

Campbell, Ben; Sallis, Paul

2013-01-01

This study looks at how potential for resilient low-carbon solutions can be understood and enhanced in the diverse environmental, economic and socio-political contexts in which actual scenarios of energy needs and diverse development pathways take shape. It discusses socio-technical transition approaches to assist implementation of a biogas digester system. This will replace fuelwood use in the high forests of Central Nepal, where yak cheese production provides livelihood income but is under threat from the Langtang National Park, which is concerned to protect biodiversity. Alternatives for digester design are discussed, and the consultative issues for deliberative processes among stakeholders’ varied agendas raised. PMID:24427516

Multicriteria Decision Framework for Cybersecurity Risk Assessment and Management.

PubMed

Ganin, Alexander A; Quach, Phuoc; Panwar, Mahesh; Collier, Zachary A; Keisler, Jeffrey M; Marchese, Dayton; Linkov, Igor

2017-09-05

Risk assessors and managers face many difficult challenges related to novel cyber systems. Among these challenges are the constantly changing nature of cyber systems caused by technical advances, their distribution across the physical, information, and sociocognitive domains, and the complex network structures often including thousands of nodes. Here, we review probabilistic and risk-based decision-making techniques applied to cyber systems and conclude that existing approaches typically do not address all components of the risk assessment triplet (threat, vulnerability, consequence) and lack the ability to integrate across multiple domains of cyber systems to provide guidance for enhancing cybersecurity. We present a decision-analysis-based approach that quantifies threat, vulnerability, and consequences through a set of criteria designed to assess the overall utility of cybersecurity management alternatives. The proposed framework bridges the gap between risk assessment and risk management, allowing an analyst to ensure a structured and transparent process of selecting risk management alternatives. The use of this technique is illustrated for a hypothetical, but realistic, case study exemplifying the process of evaluating and ranking five cybersecurity enhancement strategies. The approach presented does not necessarily eliminate biases and subjectivity necessary for selecting countermeasures, but provides justifiable methods for selecting risk management actions consistent with stakeholder and decisionmaker values and technical data. Published 2017. This article is a U.S. Government work and is in the public domain in the U.S.A.

Pancreas Transplantation With Portal-Enteric Drainage for Patients With Endocrine and Exocrine Insufficiency From Extensive Pancreatic Resection.

PubMed

Barbas, Andrew S; Al-Adra, David P; Goldaracena, Nicolas; Dib, Martin J; Selzner, Markus; Sapisochin, Gonzalo; Cattral, Mark S; McGilvray, Ian D

2017-09-01

Although the primary indication for pancreas transplantation is type I diabetes, a small number of patients requires pancreas transplantation to manage combined endocrine and exocrine insufficiency that develops after extensive native pancreatic resection. The objective of this case report was to describe the operative and clinical course in 3 such patients and present an alternative technical approach.

A minimally invasive technique for percutaneous lumbar facet augmentation: Technical description of a novel device

PubMed Central

Smith, Zachary A.; Armin, Sean; Raphael, Dan; Khoo, Larry T.

2011-01-01

Background: We describe a new posterior dynamic stabilizing system that can be used to augment the mechanics of the degenerating lumbar segment. The mechanism of this system differs from other previously described surgical techniques that have been designed to augment lumbar biomechanics. The implant and technique we describe is an extension-limiting one, and it is designed to support and cushion the facet complex. Furthermore, it is inserted through an entirely percutaneous technique. The purpose of this technical note is to demonstrate a novel posterior surgical approach for the treatment of lumbar degenerative. Methods: This report describes a novel, percutaneously placed, posterior dynamic stabilization system as an alternative option to treat lumbar degenerative disk disease with and without lumbar spinal stenosis. The system does not require a midline soft-tissue dissection, nor subperiosteal dissection, and is a truly minimally invasive means for posterior augmentation of the functional facet complex. This system can be implanted as a stand-alone procedure or in conjunction with decompression procedures. Results: One-year clinical results in nine individual patients, all treated for degenerative disease of the lower lumbar spine, are presented. Conclusions: This novel technique allows for percutaneous posterior dynamic stabilization of the lumbar facet complex. The use of this procedure may allow a less invasive alternative to traditional approaches to the lumbar spine as well as an alternative to other newly developed posterior dynamic stabilization systems. PMID:22145084

QUANTIFYING ALTERNATIVE SPLICING FROM PAIRED-END RNA-SEQUENCING DATA.

PubMed

Rossell, David; Stephan-Otto Attolini, Camille; Kroiss, Manuel; Stöcker, Almond

2014-03-01

RNA-sequencing has revolutionized biomedical research and, in particular, our ability to study gene alternative splicing. The problem has important implications for human health, as alternative splicing may be involved in malfunctions at the cellular level and multiple diseases. However, the high-dimensional nature of the data and the existence of experimental biases pose serious data analysis challenges. We find that the standard data summaries used to study alternative splicing are severely limited, as they ignore a substantial amount of valuable information. Current data analysis methods are based on such summaries and are hence sub-optimal. Further, they have limited flexibility in accounting for technical biases. We propose novel data summaries and a Bayesian modeling framework that overcome these limitations and determine biases in a non-parametric, highly flexible manner. These summaries adapt naturally to the rapid improvements in sequencing technology. We provide efficient point estimates and uncertainty assessments. The approach allows to study alternative splicing patterns for individual samples and can also be the basis for downstream analyses. We found a several fold improvement in estimation mean square error compared popular approaches in simulations, and substantially higher consistency between replicates in experimental data. Our findings indicate the need for adjusting the routine summarization and analysis of alternative splicing RNA-seq studies. We provide a software implementation in the R package casper.

Non-invasive Renal Denervation: Update on External Ultrasound Approaches.

PubMed

Schmieder, Roland E; Ott, Christian; Bramlage, Peter

2016-06-01

In the last decade, intravenous renal denervation (RDN) has emerged as an alternative to pharmacological treatment in patients with resistant hypertension, but currently involves an invasive and technically challenging procedure. The Surround Sound™ system utilises externally delivered ultrasound to achieve RDN using a completely non-invasive, automated real-time tracking system coupled with a therapeutic delivery module thereby addressing these limitations. A brief history, technical overview and summary of preclinical and clinical studies of the KonaMedical Surround Sound™ system are presented. A literature search using the terms "renal denervation", "resistant hypertension" and "external ultrasound" was performed using PubMed, and references retrieved were selected based on relevancy and year of publication (date range 1991-2015). The Surround Sound™ system appears to be a promising approach to RDN which eliminates several of the factors currently limiting the intravenous approach. So far, it has demonstrated efficacy for reducing blood pressure in resistant hypertension patients with minimal adverse effects. Several double-blind, sham-controlled clinical trials are currently underway to confirm the validity of these findings.

23 CFR 636.209 - What items must be included in a phase-two solicitation?

Code of Federal Regulations, 2010 CFR

2010-04-01

.... (b) At your discretion, you may allow proposers to submit alternate technical concepts in their proposals as long as these alternate concepts do not conflict with criteria agreed upon in the environmental decision making process. Alternate technical concept proposals may supplement, but not substitute for base...

Comparing Panelists' Understanding of Standard Setting across Multiple Levels of an Alternate Science Assessment

ERIC Educational Resources Information Center

Hansen, Mary A.; Lyon, Steven R.; Heh, Peter; Zigmond, Naomi

2013-01-01

Large-scale assessment programs, including alternate assessments based on alternate achievement standards (AA-AAS), must provide evidence of technical quality and validity. This study provides information about the technical quality of one AA-AAS by evaluating the standard setting for the science component. The assessment was designed to have…

Office of Exploration: Exploration studies technical report. Volume 2: Studies approach and results

NASA Technical Reports Server (NTRS)

Roberts, Barney B.; Bland, Dan

1988-01-01

The NASA Office of Exploration has been tasked with defining and recommending alternatives for an early 1990's national decision on a focused program of human exploration of the solar system. The Mission Analysis and System Engineering (MASE) group, which is managed by the Exploration Studies Office at the Johnson Space Center, is responsible for coordinating the technical studies necessary for accomplishing such a task. This technical report describes the process that has been developed in a case study approach. The four case studies that were developed in FY88 include: (1) human expedition to Phobos; (2) human expeditions to Mars; (3) lunar observatory; and (4) lunar outpost to early Mars evolution. The final outcome of this effort is a set of programmatic and technical conclusions and recommendations for the following year's work. Volume 2 describes the case study process, the technical results of each of the case studies, and opportunities for additional study. Included in the discussion of each case study is a description of the mission key features and profile. Mission definition and manifesting are detailed, followed by a description of the mission architecture and infrastructure. Systems concepts for the required orbital nodes, transportation systems, and planetary surface systems are discussed. Prerequisite implementation plans resulting from the synthesized case studies are described and in-depth assessments are presented.

Corrective Action Investigation Plan for Corrective Action Unit 536: Area 3 Release Site, Nevada Test Site, Nevada (Rev. 0 / June 2003), Including Record of Technical Change No. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective action alternatives (CAAs) appropriate for the closure of Corrective Action Unit (CAU) 536: Area 3 Release Site, Nevada Test Site, Nevada, under the Federal Facility Agreement and Consent Order. Corrective Action Unit 536 consists of a single Corrective Action Site (CAS): 03-44-02, Steam Jenny Discharge. The CAU 536 site is being investigated because existing information on the nature and extent of possible contamination is insufficient to evaluate and recommend corrective action alternatives formore » CAS 03-44-02. The additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating CAAs and selecting the appropriate corrective action for this CAS. The results of this field investigation are to be used to support a defensible evaluation of corrective action alternatives in the corrective action decision document. Record of Technical Change No. 1 is dated 3-2004.« less

A socio-technical critique of tiered services: implications for interprofessional care.

PubMed

Hood, Rick

2015-01-01

In the health and social care sector, tiered services have become an increasingly influential way of organising professional expertise to address the needs of vulnerable people. Drawing on its application to UK child welfare services, this paper discusses the merits of the tiered model from a socio-technical perspective - an approach that has emerged from the fields of accident analysis and systems design. The main elements of a socio-technical critique are outlined and used to explore how tiered services provide support to families and prevent harm to children. Attention is drawn to the distribution of expertise and resources in a tiered system, and to the role of referral and gate-keeping procedures in dispersing accountability for outcomes. An argument is made for designing systems "against demand", and the paper concludes by discussing some alternative models of multi-agency provision.

Satellite power system concept development and evaluation program system definition technical assessment report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-12-01

The results of the system definition studies conducted by NASA as a part of the Department of Energy/National Aeronautics and Space Administration SPS Concept Development and Evaluation Program are summarized. The purpose of the system definition efforts was to identify and define candidate SPS concepts and to evaluate the concepts in terms of technical and cost factors. Although the system definition efforts consisted primarily of evaluation and assessment of alternative technical approaches, a reference system was also defined to facilitate economic, environmental, and societal assessments by the Department of Energy. This reference system was designed to deliver 5 GW ofmore » electrical power to the utility grid. Topics covered include system definition; energy conversion and power management; power transmission and reception; structures, controls, and materials; construction and operations; and space transportation.« less

Automated dredging and disposal alternatives management system (ADDAMS). Environmental effects of dredging. Technical note

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This technical note describes the current capabilities and availability of the Automated Dredging and Disposal Alternatives Management System (ADDAMS). The technical note replaces the earlier Technical Note EEDP-06-12, which should be discarded. Planning, design, and management of dredging and dredged material disposal projects often require complex or tedious calculations or involve complex decision-making criteria. In addition, the evaluations often must be done for several disposal alternatives or disposal sites. ADDAMS is a personal computer (PC)-based system developed to assist in making such evaluations in a timely manner. ADDAMS contains a collection of computer programs (applications) designed to assist in managingmore » dredging projects. This technical note describes the system, currently available applications, mechanisms for acquiring and running the system, and provisions for revision and expansion.« less

Lessons that non-scientists can teach us about the concept of energy: a human-centred approach

NASA Astrophysics Data System (ADS)

Leggett, Monica

2003-03-01

Energy is not only a core concept in physics but also a major issue in our post-Kyoto world. When using a constructivist approach to teaching, we need to be aware of students' preconceptions. A palette of alternative frameworks, which includes those used by adults within the community, can facilitate this. An exploration of energy issues with non-scientists within the community has generated some relevant insights. Participants' concepts of energy were multifaceted. Most had a strong personal component, but also social, technical and cosmic dimensions. Although many participants were uncomfortable with the terms `renewable' and `sustainable', they clearly articulated the social and technical requirements for a shift away from current fossil fuel dependency. However, the law of conservation of energy, a core belief of physicists, appeared to be totally absent from their concept of energy.

Subxiphoid complex uniportal video-assisted major pulmonary resections.

PubMed

Gonzalez-Rivas, Diego; Lirio, Francisco; Sesma, Julio; Abu Akar, Firas

2017-01-01

In recent years, the search for a less invasive and thus, less painful approach has driven technical innovation in modern thoracic surgery. In this context, subxiphoid uniportal approach has emerged as an alternative to avoid intercostal space manipulation and decrease postoperative pain and intercostal nerve chronic impairment. Subxiphoid uniportal major lung resections have been safe and effective procedures when performed by experienced surgeons even in complex cases or unexpected intraoperative situations. We present six of these surgical scenarios such as big tumors, incomplete or absent fissures, hilar calcified lymph nodes, active bleeding and massive adhesions to show the feasibility of subxiphoid approach to manage even these conditions.

Subxiphoid complex uniportal video-assisted major pulmonary resections

PubMed Central

Lirio, Francisco; Sesma, Julio; Abu Akar, Firas

2017-01-01

In recent years, the search for a less invasive and thus, less painful approach has driven technical innovation in modern thoracic surgery. In this context, subxiphoid uniportal approach has emerged as an alternative to avoid intercostal space manipulation and decrease postoperative pain and intercostal nerve chronic impairment. Subxiphoid uniportal major lung resections have been safe and effective procedures when performed by experienced surgeons even in complex cases or unexpected intraoperative situations. We present six of these surgical scenarios such as big tumors, incomplete or absent fissures, hilar calcified lymph nodes, active bleeding and massive adhesions to show the feasibility of subxiphoid approach to manage even these conditions. PMID:29078655

Facing the rain after the phase out: Performance evaluation of alternative fluorinated and non-fluorinated durable water repellents for outdoor fabrics.

PubMed

Schellenberger, S; Gillgard, P; Stare, A; Hanning, A; Levenstam, O; Roos, S; Cousins, I T

2018-02-01

Fluorinated durable water repellent (DWR) agents are used to obtain water and stain repellent textiles. Due to the on-going phase-out of DWRs based on side-chain fluorinated polymers (SFP) with "long" perfluoroalkyl chains, the textile industry lacks suitable alternatives with comparable material characteristics. The constant development and optimization of SFPs for textile applications initiated more than half a century ago has resulted in a robust and very efficient DWR-technology and textiles with exceptional hydro- and oleo-phobic properties. The industry is now in the predicament that the long-chain SFPs with the best technical performance have undesirable toxicological and environmental behaviour. This study provides a comprehensive overview of the technical performance of presently available fluorinated and non-fluorinated DWRs as part of a chemical alternatives assessment (CAA). The results are based on a study with synthetic outdoor fabrics treated with alternative DWRs and tested for repellency using industrial standard and complementary methods. Using this approach, the complex structure-property relationships of DWR-polymers could be explained on a molecular level. Both short-chain SFPs and non-fluorinated DWRs showed excellent water repellency and durability in some cases while short-chain SFPs were the more robust of the alternatives to long-chain SFPs. A strong decline in oil repellency and durability with perfluoroalkyl chain length was shown for SFP DWRs. Non-fluorinated alternatives were unable to repel oil, which might limit their potential for substitution in textile application that require repellency towards non-polar liquids. Copyright © 2017. Published by Elsevier Ltd.

Technical Note: Higher-order statistical moments and a procedure that detects potentially anomalous years as two alternative methods describing alterations in continuous environmental data

Treesearch

I. Arismendi; S. L. Johnson; J. B. Dunham

2015-01-01

Statistics of central tendency and dispersion may not capture relevant or desired characteristics of the distribution of continuous phenomena and, thus, they may not adequately describe temporal patterns of change. Here, we present two methodological approaches that can help to identify temporal changes in environmental regimes. First, we use higher-order statistical...

STEM and Teaching German Language and Literature with an Interdisciplinary Approach: 18th-Century Reports by German Jesuit Missionaries in the German Classroom

ERIC Educational Resources Information Center

Classen, Albrecht

2018-01-01

Recent debates about the future of academia have focused primarily on teaching the STEM subjects. This is certainly a valuable call for action, but it also threatens to ignore the significant contributions of the humanities and other fields. This article presents a workable alternative by way of looking at more technical writings by 18th-century…

X-ray lasers

NASA Astrophysics Data System (ADS)

Elton, Raymond C.

Theoretical and practical aspects of X-ray lasers are discussed in an introduction emphasizing recent advances. Chapters are devoted to the unique optical properties of the X-ray spectral region, the principles of short-wavelength lasers, pumping by exciting plasma ions, pumping by electron capture into excited ionic states, pumping by ionization of atoms and ions, and alternative approaches. The potential scientific, technical, biological, and medical applications of X-ray lasers are briefly characterized.

Making sense of complex electronic records: socio-technical design in social care.

PubMed

Wastell, David; White, Sue

2014-03-01

Dealing with complex electronic documentation is an integral part of much contemporary professional work. In this paper, we address the design of electronic records for social care professionals in the UK. Recent reforms in UK child welfare have followed a top-down, managerial approach emphasizing conformance to standard processes. The vicissitudes of a major national IT project, the Integrated Children's System, show the limitations of this approach, in particular the detrimental effect it has had on professional autonomy. Following in the foot-steps of Ken Eason, we argue that socio-technical design, by focussing on innovative applications of technology to support users (rather than the interests of the bureaucracy) offers a more promising alternative. A user-centred design exercise is presented to illustrate this approach in action. A novel interface was developed for handling the heterogeneous bundle of documents which make up the social care record, helping social workers make better sense of case-files. The prototype draws on the metaphor of the dining-room table as a way of overcoming the limitations of the computer display. We conclude that socio-technical thinking engenders a shift in mind-set, opening up a radically different design space compared to current design orthodoxy. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Assessing the Total Factor Productivity of Cotton Production in Egypt

PubMed Central

Rodríguez, Xosé A.; Elasraag, Yahia H.

2015-01-01

The main objective of this paper is to decompose the productivity growth of Egyptian cotton production. We employ the stochastic frontier approach and decompose the changes in total factor productivity (CTFP) growth into four components: technical progress (TP), changes in scale component (CSC), changes in allocative efficiency (CAE), and changes in technical efficiency (CTE). Considering a situation of scarce statistical information, we propose four alternative empirical models, with the purpose of looking for convergence in the results. The results provide evidence that in this production system total productivity does not increase, which is mainly due to the negative average contributions of CAE and TP. Policy implications are offered in light of the results. PMID:25625318

Assessing the total factor productivity of cotton production in Egypt.

PubMed

Rodríguez, Xosé A; Elasraag, Yahia H

2015-01-01

The main objective of this paper is to decompose the productivity growth of Egyptian cotton production. We employ the stochastic frontier approach and decompose the changes in total factor productivity (CTFP) growth into four components: technical progress (TP), changes in scale component (CSC), changes in allocative efficiency (CAE), and changes in technical efficiency (CTE). Considering a situation of scarce statistical information, we propose four alternative empirical models, with the purpose of looking for convergence in the results. The results provide evidence that in this production system total productivity does not increase, which is mainly due to the negative average contributions of CAE and TP. Policy implications are offered in light of the results.

The quantile regression approach to efficiency measurement: insights from Monte Carlo simulations.

PubMed

Liu, Chunping; Laporte, Audrey; Ferguson, Brian S

2008-09-01

In the health economics literature there is an ongoing debate over approaches used to estimate the efficiency of health systems at various levels, from the level of the individual hospital - or nursing home - up to that of the health system as a whole. The two most widely used approaches to evaluating the efficiency with which various units deliver care are non-parametric data envelopment analysis (DEA) and parametric stochastic frontier analysis (SFA). Productivity researchers tend to have very strong preferences over which methodology to use for efficiency estimation. In this paper, we use Monte Carlo simulation to compare the performance of DEA and SFA in terms of their ability to accurately estimate efficiency. We also evaluate quantile regression as a potential alternative approach. A Cobb-Douglas production function, random error terms and a technical inefficiency term with different distributions are used to calculate the observed output. The results, based on these experiments, suggest that neither DEA nor SFA can be regarded as clearly dominant, and that, depending on the quantile estimated, the quantile regression approach may be a useful addition to the armamentarium of methods for estimating technical efficiency.

THz spectroscopy: An emerging technology for pharmaceutical development and pharmaceutical Process Analytical Technology (PAT) applications

NASA Astrophysics Data System (ADS)

Wu, Huiquan; Khan, Mansoor

2012-08-01

As an emerging technology, THz spectroscopy has gained increasing attention in the pharmaceutical area during the last decade. This attention is due to the fact that (1) it provides a promising alternative approach for in-depth understanding of both intermolecular interaction among pharmaceutical molecules and pharmaceutical product quality attributes; (2) it provides a promising alternative approach for enhanced process understanding of certain pharmaceutical manufacturing processes; and (3) the FDA pharmaceutical quality initiatives, most noticeably, the Process Analytical Technology (PAT) initiative. In this work, the current status and progress made so far on using THz spectroscopy for pharmaceutical development and pharmaceutical PAT applications are reviewed. In the spirit of demonstrating the utility of first principles modeling approach for addressing model validation challenge and reducing unnecessary model validation "burden" for facilitating THz pharmaceutical PAT applications, two scientific case studies based on published THz spectroscopy measurement results are created and discussed. Furthermore, other technical challenges and opportunities associated with adapting THz spectroscopy as a pharmaceutical PAT tool are highlighted.

Cost-effective particulate control options at Potomac Electric Power Company's Dickerson Station: An integrated approach to current and future particulate limits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christoffersen, S.W.; Rouse, G.T.; Krasnopoler, M.J.

1998-07-01

The Dickerson Generating Station evaluated several particulate control options to identify the most cost-effective option. The study's goals were to: eliminate the particulate scrubber and its high maintenance costs, and incorporate flexibility for low-sulfur coal and possible stricter emission limits. Each of the three Dickerson 190 MW units has a small 37-year-old electrostatic precipitator and a wet particulate scrubber. The study evaluated alternatives to replace the scrubber and enhance ESP performance: Existing ESP alternatives--Extend height of existing ESP; Flue gas conditioning. Scrubber stream alternatives--Partial-flow ESP or pulse jet baghouse. Full-flow alternatives--Supplemental ESP; COHPAC baghouse; replacement ESP or baghouse. A technicalmore » and economic prescreening eliminated some of the options. Capital, operating, and life cycle costs were estimated for the remaining options to determine the most cost-effective alternative. This paper will present the technical and economic evaluations done for this study, including performance and costs.« less

Regulatory aspects on the use of fish embryos in environmental toxicology.

PubMed

Halder, Marlies; Léonard, Marc; Iguchi, Taisen; Oris, James T; Ryder, Kathy; Belanger, Scott E; Braunbeck, Thomas A; Embry, Michelle R; Whale, Graham; Norberg-King, Teresa; Lillicrap, Adam

2010-07-01

Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management of chemicals and wastewater discharges. The ILSI Health and Environmental Sciences Institute and the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) held an International Workshop on the Application of the Fish Embryo Test in March, 2008. This relatively young discipline is following advances in animal alternatives for human safety sciences, and it is advisable to develop a broad comparison of how animal alternative tests involving fish are viewed in a regulatory context over a wide array of authorities or advising bodies. These include OECD, Western Europe, North America, and Japan. This paper summarizes representative practices from these regions. Presently, the global regulatory environment has varying stances regarding the protection of fish for use as an experimental animal. Such differences have a long-term potential to lead to a lack of harmony in approaches to fish toxicity testing, especially for chemicals in commerce across multiple geographic regions. Implementation of alternative methods and approaches will be most successful if accepted globally, including methods of fish toxicity testing. An important area for harmonization would be in the interpretation of protected and nonprotected life stages of fish. Use of fish embryos represent a promising alternative and allow bridging to more technically challenging alternatives with longer prospective timelines, including cell-based assays, ecotoxicogenomics, and QSARs. (c) 2010 SETAC.

Uniportal anatomic combined unusual segmentectomies.

PubMed

González-Rivas, Diego; Lirio, Francisco; Sesma, Julio

2017-01-01

Nowadays, sublobar anatomic resections are gaining momentum as a valid alternative for early stage lung cancer. Despite being technically demanding, anatomic segmentectomies can be performed by uniportal video-assisted thoracic surgery (VATS) approach to combine the benefits of minimally invasiveness with the maximum lung sparing. This procedure can be even more complex if a combined resection of multiple segments from different lobes has to be done. Here we report five cases of combined and unusual segmentectomies done by the same experienced surgeon in high volume institutions to show uniportal VATS is a feasible approach for these complex resections and to share an excellent educational resource.

A Risk-Based Approach to Variable Load Configuration Validation in Steam Sterilization: Application of PDA Technical Report 1 Load Equivalence Topic.

PubMed

Pavell, Anthony; Hughes, Keith A

2010-01-01

This article describes a method for achieving the load equivalence model, described in Parenteral Drug Association Technical Report 1, using a mass-based approach. The item and load bracketing approach allows for mixed equipment load size variation for operational flexibility along with decreased time to introduce new items to the operation. The article discusses the utilization of approximately 67 items/components (Table IV) identified for routine sterilization with varying quantities required weekly. The items were assessed for worst-case identification using four temperature-related criteria. The criteria were used to provide a data-based identification of worst-case items, and/or item equivalence, to carry forward into cycle validation using a variable load pattern. The mass approach to maximum load determination was used to bracket routine production use and allows for variable loading patterns. The result of the item mapping and load bracketing data is "a proven acceptable range" of sterilizing conditions including loading configuration and location. The application of these approaches, while initially more time/test-intensive than alternate approaches, provides a method of cycle validation with long-term benefit of ease of ongoing qualification, minimizing time and requirements for new equipment qualification for similar loads/use, and for rapid and rigorous assessment of new items for sterilization.

32 CFR 651.45 - Steps in preparing and processing an EIS.

Code of Federal Regulations, 2010 CFR

2010-07-01

... technical analyses are balanced with environmental analysis, the agency preferred alternative will not...) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Impact Statement § 651.45... alternatives based on relevant factors including environmental, economic, and technical considerations and...

Evaluating cardiac risk: exposure response analysis in early clinical drug development.

PubMed

Grenier, Julie; Paglialunga, Sabina; Morimoto, Bruce H; Lester, Robert M

2018-01-01

The assessment of a drug's cardiac liability has undergone considerable metamorphosis by regulators since International Council for Harmonization of Technical Requirement for Pharmaceuticals for Human Use E14 guideline was introduced in 2005. Drug developers now have a choice in how proarrhythmia risk can be evaluated; the options include a dedicated thorough QT (TQT) study or exposure response (ER) modeling of intensive electrocardiogram (ECG) captured in early clinical development. The alternative approach of ER modeling was incorporated into a guidance document in 2015 as a primary analysis tool which could be utilized in early phase dose escalation studies as an option to perform a dedicated TQT trial. This review will describe the current state of ER modeling of intensive ECG data collected during early clinical drug development; the requirements with regard to the use of a positive control; and address the challenges and opportunities of this alternative approach to assessing QT liability.

Reverse Transrectal Stapling Technique Using the EEA Stapler: An Alternative Approach in Difficult Reversal of Hartmann’s Procedure

PubMed Central

Zachariah, Sanoop K.

2010-01-01

The introduction of circular end-to-end stapling devices (CEEA OR EEA stapler) into colorectal surgery have revolutionised anastomotic techniques. The EEA stapler is generally regarded as an instrument that is safe, reliable, and simple to operate. Despite it’s popularity, very little information is available regarding the technical difficulties encountered during surgery. The routine technique to perform an end-to-end circular colonic anastomosis is to introduce the instrument distally through the anus (transrectal/transanal approach) and attach it to the anvil which is purse stringed at the distal end of the proximal bowel to be anastomosed. Two cases of reversal of Hartmann’s procedure for perforated diverticulitis are described in the present study, where difficulty was experienced while using the EEA stapler in the routine method. Hence, an alternative reverse technique which was used is presented. PMID:22091338

Quantitative proteomics in cardiovascular research: global and targeted strategies

PubMed Central

Shen, Xiaomeng; Young, Rebeccah; Canty, John M.; Qu, Jun

2014-01-01

Extensive technical advances in the past decade have substantially expanded quantitative proteomics in cardiovascular research. This has great promise for elucidating the mechanisms of cardiovascular diseases (CVD) and the discovery of cardiac biomarkers used for diagnosis and treatment evaluation. Global and targeted proteomics are the two major avenues of quantitative proteomics. While global approaches enable unbiased discovery of altered proteins via relative quantification at the proteome level, targeted techniques provide higher sensitivity and accuracy, and are capable of multiplexed absolute quantification in numerous clinical/biological samples. While promising, technical challenges need to be overcome to enable full utilization of these techniques in cardiovascular medicine. Here we discuss recent advances in quantitative proteomics and summarize applications in cardiovascular research with an emphasis on biomarker discovery and elucidating molecular mechanisms of disease. We propose the integration of global and targeted strategies as a high-throughput pipeline for cardiovascular proteomics. Targeted approaches enable rapid, extensive validation of biomarker candidates discovered by global proteomics. These approaches provide a promising alternative to immunoassays and other low-throughput means currently used for limited validation. PMID:24920501

Technical report analysis and design: Study of solid rocket motors for a space shuttle booster, volume 2, book 1, supplement 1

NASA Technical Reports Server (NTRS)

1972-01-01

An analysis and design effort was conducted as part of the study of solid rocket motor for a space shuttle booster. The 156-inch-diameter, parallel burn solid rocket motor was selected as its baseline because it is transportable and is the most cost-effective, reliable system that has been developed and demonstrated. The basic approach was to concentrate on the selected baseline design, and to draw from the baseline sufficient data to describe the alternate approaches also studied. The following conclusions were reached with respect to technical feasibility of the use of solid rocket booster motors for the space shuttle vehicle: (1) The 156-inch, parallel-burn baseline SRM design meets NASA's study requirements while incorporating conservative safety factors. (2) The solid rocket motor booster represents a cost-effective approach. (3) Baseline costs are conservative and are based on a demonstrated design. (4) Recovery and reuse are feasible and offer substantial cost savings. (5) Abort can be accomplished successfully. (6) Ecological effects are acceptable.

47 CFR 80.481 - Alternative technical parameters for AMTS transmitters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Alternative technical parameters for AMTS transmitters. 80.481 Section 80.481 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Public Coast Stations Automated Systems § 80.481...

Intradural Procedural Time to Assess Technical Difficulty of Superciliary Keyhole and Pterional Approaches for Unruptured Middle Cerebral Artery Aneurysms

PubMed Central

Choi, Yeon-Ju; Son, Wonsoo; Park, Ki-Su

2016-01-01

Objective This study used the intradural procedural time to assess the overall technical difficulty involved in surgically clipping an unruptured middle cerebral artery (MCA) aneurysm via a pterional or superciliary approach. The clinical and radiological variables affecting the intradural procedural time were investigated, and the intradural procedural time compared between a superciliary keyhole approach and a pterional approach. Methods During a 5.5-year period, patients with a single MCA aneurysm were enrolled in this retrospective study. The selection criteria for a superciliary keyhole approach included : 1) maximum diameter of the unruptured MCA aneurysm <15 mm, 2) neck diameter of the MCA aneurysm <10 mm, and 3) aneurysm location involving the sphenoidal or horizontal segment of MCA (M1) segment and MCA bifurcation, excluding aneurysms distal to the MCA genu. Meanwhile, the control comparison group included patients with the same selection criteria as for a superciliary approach, yet who preferred a pterional approach to avoid a postoperative facial wound or due to preoperative skin trouble in the supraorbital area. To determine the variables affecting the intradural procedural time, a multiple regression analysis was performed using such data as the patient age and gender, maximum aneurysm diameter, aneurysm neck diameter, and length of the pre-aneurysm M1 segment. In addition, the intradural procedural times were compared between the superciliary and pterional patient groups, along with the other variables. Results A total of 160 patients underwent a superciliary (n=124) or pterional (n=36) approach for an unruptured MCA aneurysm. In the multiple regression analysis, an increase in the diameter of the aneurysm neck (p<0.001) was identified as a statistically significant factor increasing the intradural procedural time. A Pearson correlation analysis also showed a positive correlation (r=0.340) between the neck diameter and the intradural procedural time. When comparing the superciliary and pterional groups, no statistically significant between-group difference was found in terms of the intradural procedural time reflecting the technical difficulty (mean±standard deviation : 29.8±13.0 min versus 27.7±9.6 min). Conclusion A superciliary keyhole approach can be a useful alternative to a pterional approach for an unruptured MCA aneurysm with a maximum diameter <15 mm and neck diameter <10 mm, representing no more of a technical challenge. For both surgical approaches, the technical difficulty increases along with the neck diameter of the MCA aneurysm. PMID:27847568

Trust-Based Security Level Evaluation Using Bayesian Belief Networks

NASA Astrophysics Data System (ADS)

Houmb, Siv Hilde; Ray, Indrakshi; Ray, Indrajit; Chakraborty, Sudip

Security is not merely about technical solutions and patching vulnerabilities. Security is about trade-offs and adhering to realistic security needs, employed to support core business processes. Also, modern systems are subject to a highly competitive market, often demanding rapid development cycles, short life-time, short time-to-market, and small budgets. Security evaluation standards, such as ISO 14508 Common Criteria and ISO/IEC 27002, are not adequate for evaluating the security of many modern systems for resource limitations, time-to-market, and other constraints. Towards this end, we propose an alternative time and cost effective approach for evaluating the security level of a security solution, system or part thereof. Our approach relies on collecting information from different sources, who are trusted to varying degrees, and on using a trust measure to aggregate available information when deriving security level. Our approach is quantitative and implemented as a Bayesian Belief Network (BBN) topology, allowing us to reason over uncertain information and seemingly aggregating disparate information. We illustrate our approach by deriving the security level of two alternative Denial of Service (DoS) solutions. Our approach can also be used in the context of security solution trade-off analysis.

Procurement engineering - the productivity factor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bargerstock, S.B.

1993-01-01

The industry is several years on the road to implementation of the Nuclear Management and Resources Council (NUMARC) initiatives on commercial-grade item dedication and procurement. Utilities have taken several approaches to involve engineering in the procurement process. A common result for the approaches is the additional operations and maintenance (O M) cost imposed by the added resource requirements. Procurement engineering productivity is a key element in controlling this business area. Experience shows that 400 to 500% improvements in productivity are possible with a 2-yr period. Improving the productivity of the procurement engineering function is important in today's competitive utility environment.more » Procurement engineering typically involves four distinct technical evaluation responsibilities along with several administrative areas. Technical evaluations include the functionally based safety classification of replacement components and parts (lacking a master parts list), the determination of dedication requirements for safety-related commercial-grade items, the preparation of a procurement specification to maintain the licensed design bases, and the equivalency evaluation of alternate items not requiring the design-change process. Administrative duties include obtaining technical review of vendor-supplied documentation, identifying obsolete parts and components, resolving material nonconformances, initiating the design-change process for replacement items (as needed), and providing technical support to O M. Although most utilities may not perform or require all the noted activities, a large percentage will apply to each utility station.« less

Life cycle assessment and sustainable engineering in the context of near net shape grown components: striving towards a sustainable way of future production.

PubMed

Kämpfer, Christoph; Seiler, Thomas-Benjamin; Beger, Anna-Lena; Jacobs, Georg; Löwer, Manuel; Moser, Franziska; Reimer, Julia; Trautz, Martin; Usadel, Björn; Wormit, Alexandra; Hollert, Henner

2017-01-01

Technical product harvesting (TEPHA) is a newly developing interdisciplinary approach in which bio-based production is investigated from a technical and ecological perspective. Society's demand for ecologically produced and sustainably operable goods is a key driver for the substitution of conventional materials like metals or plastics through bio-based alternatives. Technical product harvesting of near net shape grown components describes the use of suitable biomass for the production of technical products through influencing the natural shape of plants during their growth period. The use of natural materials may show positive effects on the amount of non-renewable resource consumption. This also increases the product recyclability at the end of its life cycle. Furthermore, through the near net shape growth of biomass, production steps can be reduced. As a consequence such approaches may save energy and the needed resources like crude oil, coal or gas. The derived near net shape grown components are not only considered beneficial from an environmental point of view. They can also have mechanical advantages through an intrinsic topology optimization in contrast to common natural materials, which are influenced in their shape after harvesting. In order to prove these benefits a comprehensive, interdisciplinary scientific strategy is needed. Here, both mechanical investigations and life cycle assessment as a method of environmental evaluation are used.

Technically Speaking: On the Structure and Experience of Interaction Involving Augmentative Alternative Communications

ERIC Educational Resources Information Center

Engelke, Christopher Robert

2013-01-01

Technically Speaking: On the Structure and Experience of Interaction Involving Augmentative Alternative Communications examines the ways that communication is structured and experienced by looking at interactions involving augmented communicators--people with severe speech disabilities who use forms of assistive technology in order to communicate…

Current principles and practice in autologous intraportal islet transplantation: a meta-analysis of the technical considerations.

PubMed

Kumar, Rohan; Chung, Wen Yuan; Dennison, Ashley Robert; Garcea, Giuseppe

2016-04-01

Autologous islet transplantation (IAT) following pancreatectomy is now a recognized, albeit highly specialized procedure carried out in a small number of centers worldwide. Current clinical principles and best practice with emphasis on examining the technical aspects of surgery in centers with significant IAT experience are reviewed. Literature search for studies discussing any technical aspect of pancreatectomy with intraportal IAT was included. Thirty-five papers were included; all were single-center case series. The indications, surgical approach to pancreatectomy with IAT, islet yield, static pancreas preservation prior to islet digestion, portal vein access, absolute islet infusion volumes, and portal venous pressure changes during transfusion evaluated. IAT is considered a "last resort" when alternative approaches have been exhausted. Pre-morbid histology and prior surgical drainage adversely influence islet yields and may influence the clinical decision to perform pancreatectomy and IAT. Following pancreas digestion, absolute numbers of islets recovered and smaller islet size predict rates of insulin independence following IAT. Islet volumes and portal venous pressure changes are important factors for the development of complications. Surgical access for IAT includes intra-operative, immediate or delayed infusion via an "exteriorized" vein, and radiological percutaneous approaches. Delayed infusion can be combined with pancreas preservation techniques prior to islet isolation. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Deployment Area Selection and Land Withdrawal/Acquisition. M-X/MPS (M-X/Multiple Protective Shelter) Environmental Technical Report. Power and Energy.

DTIC Science & Technology

1981-10-02

acceptable levels under the worst case condition of coal firing. The flue gas desulfurization system would be designed to reduce the sulfer dioxide content...approaches taken. There exists federal statutory authority to implement gas rationing under certain conditions. Thus, federal controls on oil production...such as air quality deterioration, water consumption, P wastewater generation, disposal of flue gas scrubbing sludge, and ash. Another alternative is

Comparative Analysis of Sustainable Approaches and Systems for Scientific Data Stewardship

NASA Astrophysics Data System (ADS)

Downs, R. R.; Chen, R. S.

2012-12-01

Sustainable data systems are critical components of the cyberinfrastructure needed to provide long-term stewardship of scientific data, including Earth science data, throughout their entire life cycle. A variety of approaches may help ensure the sustainability of such systems, but these approaches must be able to survive the demands of competing priorities and decreasing budgets. Analyzing and comparing alternative approaches can identify viable aspects of each approach and inform decisions for developing, managing, and supporting the cyberinfrastructure needed to facilitate discovery, access, and analysis of data by future communities of users. A typology of sustainability approaches is proposed, and example use cases are offered for comparing the approaches over time. These examples demonstrate the potential strengths and weaknesses of each approach under various conditions and with regard to different objectives, e.g., open vs. limited access. By applying the results of these analyses to their particular circumstances, systems stakeholders can assess their options for a sustainable systems approach along with other metrics and identify alternative strategies to ensure the sustainability of the scientific data and information for which they are responsible. In addition, comparing sustainability approaches should inform the design of new systems and the improvement of existing systems to meet the needs for long-term stewardship of scientific data, and support education and workforce development efforts needed to ensure that the appropriate scientific and technical skills are available to operate and further develop sustainable cyberinfrastructure.

Post Game Analysis: Using Video-Based Coaching for Continuous Professional Development

PubMed Central

Hu, Yue-Yung; Peyre, Sarah E.; Arriaga, Alexander F.; Osteen, Robert T.; Corso, Katherine A.; Weiser, Thomas G.; Swanson, Richard S.; Ashley, Stanley W.; Raut, Chandrajit P.; Zinner, Michael J.; Gawande, Atul A.; Greenberg, Caprice C.

2011-01-01

Background The surgical learning curve persists for years after training, yet existing CME efforts targeting this are limited. We describe a pilot study of a scalable video-based intervention, providing individualized feedback on intra-operative performance. Study Design Four complex operations performed by surgeons of varying experience – a chief resident accompanied by the operating senior surgeon, a surgeon with <10 years in practice, another with 20–30 years, and a surgeon with >30 years of experience – were video-recorded. Video playback formed the basis of 1-hour coaching sessions with a peer-judged surgical expert. These sessions were audio-recorded, transcribed, and thematically coded. Results The sessions focused on operative technique, both technical aspects and decision-making. With increasing seniority, more discussion was devoted to the optimization of teaching and facilitation of the resident’s technical performance. Coaching sessions with senior surgeons were peer-to-peer interactions, with each discussing his preferred approach. The coach alternated between directing the session (asking probing questions) and responding to specific questions brought by the surgeons, depending on learning style. At all experience levels, video review proved valuable in identifying episodes of failure-to-progress and troubleshooting alternative approaches. All agreed this tool is a powerful one. Inclusion of trainees seems most appropriate when coaching senior surgeons; it may restrict the dialogue of more junior attendings. Conclusions Video-based coaching is an educational modality that targets intra-operative judgment, technique, and teaching. Surgeons of all levels found it highly instructive. This may provide a practical, much needed approach for continuous professional development. PMID:22192924

Comparison of two metrological approaches for the prediction of human haptic perception

NASA Astrophysics Data System (ADS)

Neumann, Annika; Frank, Daniel; Vondenhoff, Thomas; Schmitt, Robert

2016-06-01

Haptic perception is regarded as a key component of customer appreciation and acceptance for various products. The prediction of customers’ haptic perception is of interest both during product development and production phases. This paper presents the results of a multivariate analysis between perceived roughness and texture related surface measurements, to examine whether perceived roughness can be accurately predicted using technical measurements. Studies have shown that standardized measurement parameters, such as the roughness coefficients (e.g. Rz or Ra), do not show a one-dimensional linear correlation with the human perception (of roughness). Thus, an alternative measurement method was compared to standard measurements of roughness, in regard to its capability of predicting perceived roughness through technical measurements. To estimate perceived roughness, an experimental study was conducted in which 102 subjects evaluated four sets of 12 different geometrical surface structures regarding their relative perceived roughness. The two different metrological procedures were examined in relation to their capability to predict the perceived roughness of the subjects stated within the study. The standardized measurements of the surface roughness were made using a structured light 3D-scanner. As an alternative method, surface induced vibrations were measured by a finger-like sensor during robot-controlled traverse over a surface. The presented findings provide a better understanding of the predictability of human haptic perception using technical measurements.

Uniportal anatomic combined unusual segmentectomies

PubMed Central

Lirio, Francisco; Sesma, Julio

2017-01-01

Nowadays, sublobar anatomic resections are gaining momentum as a valid alternative for early stage lung cancer. Despite being technically demanding, anatomic segmentectomies can be performed by uniportal video-assisted thoracic surgery (VATS) approach to combine the benefits of minimally invasiveness with the maximum lung sparing. This procedure can be even more complex if a combined resection of multiple segments from different lobes has to be done. Here we report five cases of combined and unusual segmentectomies done by the same experienced surgeon in high volume institutions to show uniportal VATS is a feasible approach for these complex resections and to share an excellent educational resource. PMID:29078653

Iterative Reconstruction Techniques in Abdominopelvic CT: Technical Concepts and Clinical Implementation.

PubMed

Patino, Manuel; Fuentes, Jorge M; Singh, Sarabjeet; Hahn, Peter F; Sahani, Dushyant V

2015-07-01

This article discusses the clinical challenge of low-radiation-dose examinations, the commonly used approaches for dose optimization, and their effect on image quality. We emphasize practical aspects of the different iterative reconstruction techniques, along with their benefits, pitfalls, and clinical implementation. The widespread use of CT has raised concerns about potential radiation risks, motivating diverse strategies to reduce the radiation dose associated with CT. CT manufacturers have developed alternative reconstruction algorithms intended to improve image quality on dose-optimized CT studies, mainly through noise and artifact reduction. Iterative reconstruction techniques take unique approaches to noise reduction and provide distinct strength levels or settings.

Formalization and Interaction: Toward a Comprehensive History of Technology-Related Knowledge in Early Modern Europe.

PubMed

Popplow, Marcus

2015-12-01

Recent critical approaches to what has conventionally been described as "scientific" and "technical" knowledge in early modern Europe have provided a wealth of new insights. So far, the various analytical concepts suggested by these studies have not yet been comprehensively discussed. The present essay argues that such comprehensive approaches might prove of special value for long-term and cross-cultural reflections on technology-related knowledge. As heuristic tools, the notions of "formalization" and "interaction" are proposed as part of alternative narratives to those highlighting the emergence of "science" as the most relevant development for technology-related knowledge in early modern Europe.

Multi-criteria decision aid approach for the selection of the best compromise management scheme for ELVs: the case of Cyprus.

PubMed

Mergias, I; Moustakas, K; Papadopoulos, A; Loizidou, M

2007-08-25

Each alternative scheme for treating a vehicle at its end of life has its own consequences from a social, environmental, economic and technical point of view. Furthermore, the criteria used to determine these consequences are often contradictory and not equally important. In the presence of multiple conflicting criteria, an optimal alternative scheme never exists. A multiple-criteria decision aid (MCDA) method to aid the Decision Maker (DM) in selecting the best compromise scheme for the management of End-of-Life Vehicles (ELVs) is presented in this paper. The constitution of a set of alternatives schemes, the selection of a list of relevant criteria to evaluate these alternative schemes and the choice of an appropriate management system are also analyzed in this framework. The proposed procedure relies on the PROMETHEE method which belongs to the well-known family of multiple criteria outranking methods. For this purpose, level, linear and Gaussian functions are used as preference functions.

Harmonisation of animal testing alternatives in China.

PubMed

Cheng, Shujun; Qu, Xiaoting; Qin, Yao

2017-12-01

More and more countries are lining up to follow the EU's approach and implement a full ban on the sale of cosmetics that have been tested on animals, which has been the case in the EU since 2013. Besides animal welfare considerations, the need for mutual acceptance of data (MAD) and harmonisation of the global market have made the move toward non-animal testing a desirable general trend for countries worldwide. Over the last 10 years, the concept of alternative methods has been gradually developing in China. This has seen the harmonisation of relevant legislation, the organisation of various theoretical and hands-on training sessions, the exploration of method validation, the adoption of internationally recognised methods, the propagation of alternative testing standards, and an in-depth investigation into the potential use of in vitro methods in the biosciences. There are barriers to this progress, including the demand for a completely new infrastructure, the need to build technology capability, the requirement for a national standardisation system formed through international co-operation, and the lack of technical assistance to facilitate self-innovation. China is now increasing speed in harmonising its approach to the use of non-animal alternatives, accelerating technological development and attempting to incorporate non-animal, in vitro, testing methods into the national regulatory system.

Career-Technical Education--The Immediate Need for Work-Based Curriculum.

ERIC Educational Resources Information Center

Nee, John G.

1994-01-01

Career-technical education may be informal on-the-job training, organized workplace education, community college or technical institute programs, or apprenticeships, internships, and cooperative agreements. Another alternative is polytechnical education: providing technical and general studies for adults in existing school facilities after school…

Book Review: Water Diplomacy: A Negotiated Approach to Managing Complex Water Networks

NASA Astrophysics Data System (ADS)

Hossain, Faisal

2013-01-01

All nations have built their economies around water that is naturally available. Almost all sectors of the economy depend on water. Yet there is conflict among various users for the finite amount of water that is available. Managers and practitioners have long held the notion that competition rather than collaboration is the solution when there is conflict. Water Diplomacy: A Negotiated Approach to Managing Complex Water Networks, by Shafiqul Islam and Lawrence Susskind, provides a refreshingly compelling alternative to overcoming water conflicts. The book argues that the dynamic sociopolitical and socioeconomic constraints of water resources are best addressed in a "diplomacy" framework. The book rebuts, using several case studies, the technically rigid competition approach of today's water sharing practice.

Reference Mission Version 3.0 Addendum to the Human Exploration of Mars: The Reference Mission of the NASA Mars Exploration Study Team. Addendum; 3.0

NASA Technical Reports Server (NTRS)

Drake, Bret G. (Editor)

1998-01-01

This Addendum to the Mars Reference Mission was developed as a companion document to the NASA Special Publication 6107, "Human Exploration of Mars: The Reference Mission of the NASA Mars Exploration Study Team." It summarizes changes and updates to the Mars Reference Missions that were developed by the Exploration Office since the final draft of SP 6107 was printed in early 1999. The Reference Mission is a tool used by the exploration community to compare and evaluate approaches to mission and system concepts that could be used for human missions to Mars. It is intended to identify and clarify system drivers, significant sources of cost, performance, risk, and schedule variation. Several alternative scenarios, employing different technical approaches to solving mission and technology challenges, are discussed in this Addendum. Comparing alternative approaches provides the basis for continual improvement to technology investment plan and a general understanding of future human missions to Mars. The Addendum represents a snapshot of work in progress in support of planning for future human exploration missions through May 1998.

Measuring Turbulence from Moored Acoustic Doppler Velocimeters. A Manual to Quantifying Inflow at Tidal Energy Sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kilcher, Levi; Thomson, Jim; Talbert, Joe

This work details a methodology for measuring hub height inflow turbulence using moored acoustic Doppler velocimiters (ADVs). This approach is motivated by the shortcomings of alternatives. For example, remote velocity measurements (i.e., from acoustic Doppler profilers) lack sufficient precision for device simulation, and rigid tower-mounted measurements are very expensive and technically challenging in the tidal environment. Moorings offer a low-cost, site-adaptable and robust deployment platform, and ADVs provide the necessary precision to accurately quantify turbulence.

Symposium on electron linear accelerators in honor of Richard B. Neal's 80th birthday: Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Siemann, R.H.

The papers presented at the conference are: (1) the construction of SLAC and the role of R.B. Neal; (2) symposium speech; (3) lessons learned from the SLC; (4) alternate approaches to future electron-positron linear colliders; (5) the NLC technical program; (6) advanced electron linacs; (7) medical uses of linear accelerators; (8) linac-based, intense, coherent X-ray source using self-amplified spontaneous emission. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

Washtenaw Technical Middle College--High School for the High Tech.

ERIC Educational Resources Information Center

Vandenberg, Victoria

1996-01-01

An alternative high school, called a technical middle college, focuses on preparing students for technical careers; it is articulated with Washtenaw Community College. The curriculum integrates applied academics, especially math and science, with work-based learning, giving students technical knowledge and workplace experience. (Author/JOW)

Percutaneous closure of a giant left ventricular wall pseudoaneurysm: Anterograde approach with a double snare technique.

PubMed

Afonso Nogueira, Marta; Fiarresga, António; de Sousa, Lídia; Agapito, Ana; Galrinho, Ana; Cruz Ferreira, Rui

2016-01-01

Left ventricular pseudoaneurysm is a rare complication of acute myocardial infarction, cardiac surgery, trauma or infection. Since surgical repair is associated with high morbidity and mortality, percutaneous closure has been described as an alternative. In this regard, we present a case in which a symptomatic large left ventricular pseudoaneurysm was treated by percutaneous closure due to the patient's high surgical risk, using a double snare technique. Despite the technical difficulties, this procedure had a good final result followed by clinical success, confirming that this procedure is an effective alternative to surgery in high-risk patients. Copyright © 2016 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

Perceptions on the First Year of Teaching from Alternatively Certified Career and Technical Education Teachers

ERIC Educational Resources Information Center

Ball, Aaron E.

2016-01-01

Increasing teacher shortages in Career and Technical Education have resulted in changes in the routes to teacher certification. As the gap widens between available traditionally certified teachers and the openings available, administrators will continue to turn to alternative means to fill positions. Arizona has responded to this by changing…

An Exploration of Alternative Scoring Methods Using Curriculum-Based Measurement in Early Writing

ERIC Educational Resources Information Center

Allen, Abigail A.; Poch, Apryl L.; Lembke, Erica S.

2018-01-01

This manuscript describes two empirical studies of alternative scoring procedures used with curriculum-based measurement in writing (CBM-W). Study 1 explored the technical adequacy of a trait-based rubric in first grade. Study 2 explored the technical adequacy of a trait-based rubric, production-dependent, and production-independent scores in…

Commercial Building Energy Asset Score Program Overview and Technical Protocol (Version 1.1)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Na; Goel, Supriya; Makhmalbaf, Atefe

The U.S. Department of Energy (DOE) is developing a voluntary national scoring system for commercial buildings to help building owners and managers assess a building’s energy-related systems independent of operations. The goal of the score is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system, known as the Commercial Building Energy Asset Score, will allow building owners and managers to compare their building infrastructure against peers and track building upgrades over time. The system will also help other building stakeholders (e.g., building investors, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in amore » way that is independent from operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset scoring tool. The alternative methods that were considered prior to developing the current approach are described in the Program Overview and Technical Protocol Version 1.0.« less

Transcaval approach for endovascular aortic interventions: A systematic review.

PubMed

Wee, Ian Jun Yan; Syn, Nicholas; Choong, Andrew M T L

2018-05-24

The caval-aortic path is a novel access route for endovascular aortic interventions in aortic interventions, particularly for patients unsuitable for traditional access routes including femoral, subclavian, transapical, and aortic. A systematic review was conducted as per the PRISMA guidelines utilizing three electronic databases: Medline, Embase, and Cochrane database. There were 10 studies identified, including 7 retrospective studies, 1 prospective cohort study, and 2 case reports. Data on 209 patients (mean age 79.5±5.1 years; 51.2% male) were abstracted including preoperative work-up, technical procedure details, and outcomes. The overall technical success rate for all procedures is 96.2%, with a 4.3% mortality rate and a mean follow up of 17.9±19.8 months. Individually in the various interventions, the technical success rate of transcaval endoleak repair and transcatheter aortic valve implantation (TAVI) was 94.4% and 97.5% respectively, with a low 30-day mortality rate of 7.6% in the TAVI intervention. There is encouraging evidence regarding the rates of mortality and complications in the transcaval approach for endovascular aortic interventions. It presents a feasible alternative for a judiciously select group of patients who are not suitable for other access routes. Copyright © 2018 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, F.M. Jr.; Best, D.A.; Clarke, R.T.

The need for even more efficient reservoir characterization and management has forced a change in the way Mobil Oil provides technical support to its production operations. We`ve learned that to be successful, a good understanding of the reservoir is essential. This includes an understanding of the technical and business significance of reservoir heterogeneities at different stages of field development. A multi-disciplinary understanding of the business of integrated reservoir characterization is essential and to facilitate this understanding, Mobil has developed a highly successful {open_quotes}Reservoir Characterization Field Seminar{close_quotes}. Through specific team based case studies that incorporate outcrop examples and data the programmore » provides participants the opportunity to explore historic and alternative approaches to reservoir description, characterization and management. We explore appropriate levels and timing of data gathering, technology applications, risk assessment and management practices at different stages of field development. The case studies presented throughout the course are a unique element of the program which combine real life and hypothetical problem sets that explore how different technical disciplines interact, the approaches to a problem solving they use, the assumptions and uncertainties contained in their contributions and the impact those conclusions may have on other disciplines involved in the overall reservoir management process. The team building aspect of the course was an added bonus.« less

Endolymphatic Thoracic Duct Stent-Graft Reconstruction for Chylothorax: Approach, Technical Success, Safety, and Short-term Outcomes.

PubMed

Srinivasa, Rajiv N; Chick, Jeffrey Forris Beecham; Hage, Anthony N; Gemmete, Joseph J; Murrey, Douglas C; Srinivasa, Ravi N

2018-04-01

To report approach, technical success, safety, and short-term outcomes of thoracic duct stent-graft reconstruction for the treatment of chylothorax. Two patients, 1 (50%) male and 1 (50%) female, with mean age of 38 years (range: 16-59 years) underwent endolymphatic thoracic duct stent-graft reconstruction between September 2016 and July 2017. Patients had radiographic left-sided chylothoraces (n = 2) from idiopathic causes (n = 1) and heart transplantation (n = 1). In both (100%) patients, antegrade lymphatic access was used to opacify the thoracic duct after which retrograde access was used for thoracic duct stent-graft placement. Pelvic lymphangiography technical success, antegrade cisterna chyli cannulation technical success, thoracic duct opacification technical success, retrograde thoracic duct access technical success, thoracic duct stent-graft reconstruction technical success, ethiodized oil volume, contrast volume, estimated blood loss, procedure time, fluoroscopy time, radiation dose, clinical success, complications, deaths, and follow-up were recorded. Pelvic lymphangiography, antegrade cisterna chyli cannulation, thoracic duct opacification, retrograde thoracic duct access, and thoracic duct stent-graft reconstruction were technically successful in both (100%) patients. Mean ethiodized oil volume was 8 mL (range: 5-10 mL). Mean contrast volume was 13 mL (range: 5-20 mL). Mean estimated blood loss was 13 mL (range: 10-15 mL). Mean fluoroscopy time was 50.4 min (range: 31.2-69.7 min). Mean dose area product and reference air kerma were 954.4 μGmy 2 (range: 701-1,208 μGmy 2 ) and 83.5 mGy (range: 59-108 mGy), respectively. Chylothorax resolved in both (100%) patients. There were no minor or major complications directly related to the procedure. Thoracic duct stent-graft reconstruction may be a technically successful and safe alternative to thoracic duct embolization, disruption, and surgical ligation for the treatment of chylothorax. Additional studies are warranted. Copyright © 2017 Elsevier Inc. All rights reserved.

76 FR 9777 - Recent Postings of Broadly Applicable Alternative Test Methods

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-22

... Applicable Alternative Test Methods AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of availability. SUMMARY: This notice announces the broadly applicable alternative test method approval decisions... technical questions about individual alternative test method decisions, refer to the contact person...

75 FR 82061 - Lake Champlain Sea Lamprey Control Alternatives Workgroup

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

...] Lake Champlain Sea Lamprey Control Alternatives Workgroup AGENCY: Fish and Wildlife Service, Interior... of the Lake Champlain Sea Lamprey Control Alternatives Workgroup (Workgroup). The Workgroup's purpose... sea lamprey control techniques alternative to lampricide that are technically feasible, cost effective...

Innovations in energy expenditure assessment.

PubMed

Achamrah, Najate; Oshima, Taku; Genton, Laurence

2018-06-15

Optimal nutritional therapy has been associated with better clinical outcomes and requires providing energy as closed as possible to measured energy expenditure. We reviewed the current innovations in energy expenditure assessment in humans, focusing on indirect calorimetry and other new alternative methods. Although considered the reference method to measure energy expenditure, the use of indirect calorimetry is currently limited by the lack of an adequate device. However, recent technical developments may allow a broader use of indirect calorimetry for in-patients and out-patients. An ongoing international academic initiative to develop a new indirect calorimeter aimed to provide innovative and affordable technical solutions for many of the current limitations of indirect calorimetry. New alternative methods to indirect calorimetry, including CO2 measurements in mechanically ventilated patients, isotopic approaches and accelerometry-based fitness equipments, show promises but have been either poorly studied and/or are not accurate compared to indirect calorimetry. Therefore, to date, energy expenditure measured by indirect calorimetry remains the gold standard to guide nutritional therapy. Some new innovative methods are demonstrating promises in energy expenditure assessment, but still need to be validated. There is an ongoing need for easy-to-use, accurate and affordable indirect calorimeter for daily use in in-patients and out-patients.

Evaluating disease management program effectiveness: an introduction to time-series analysis.

PubMed

Linden, Ariel; Adams, John L; Roberts, Nancy

2003-01-01

Currently, the most widely used method in the disease management (DM) industry for evaluating program effectiveness is referred to as the "total population approach." This model is a pretest-posttest design, with the most basic limitation being that without a control group, there may be sources of bias and/or competing extraneous confounding factors that offer a plausible rationale explaining the change from baseline. Furthermore, with the current inclination of DM programs to use financial indicators rather than program-specific utilization indicators as the principal measure of program success, additional biases are introduced that may cloud evaluation results. This paper presents a non-technical introduction to time-series analysis (using disease-specific utilization measures) as an alternative, and more appropriate, approach to evaluating DM program effectiveness than the current total population approach.

Alternative Assessments in Practice Data Base. Project 1.2: Technical Assistance on Assessment Issues. Annual Report of Communication, Training and Dissemination Activities.

ERIC Educational Resources Information Center

Center for Research on Evaluation, Standards, and Student Testing, Los Angeles, CA.

The Center for Research on Evaluation, Standards, and Student Testing (CRESST) has developed an Alternative Assessments in Practice Data Base to support technical assistance needs and to promote the exchange of new assessment ideas. The database is designed to provide easy access and retrieval of information about ongoing and newly developed…

76 FR 43698 - Lake Champlain Sea Lamprey Control Alternatives Workgroup

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

...] Lake Champlain Sea Lamprey Control Alternatives Workgroup AGENCY: Fish and Wildlife Service, Interior... of the Lake Champlain Sea Lamprey Control Alternatives Workgroup (Workgroup). The Workgroup's purpose... implementation of sea lamprey control techniques alternative to lampricide that are technically feasible, cost...

Potential Alternatives Report for Validation of Alternative Low-Emission Surface PreparationlDepainting Technologies for Structural Steel

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2006-01-01

For this project, particulates and solvents used during the depainting process of steel structures were the identified hazardous material (HazMat) targeted for elimination or reduction. This Potential Alternatives Report (PAR) provides technical analyses of identified alternatives to the current coating removal processes, criteria used to select alternatives for further analysis, and a list of those alternatives recommended for testing. The initial coating removal alternatives list was compiled using literature searches and center participant recommendations. The involved project participants initially considered fifteen (15) alternatives. In late 2004, stakeholders down-selected the list and identified specific processes as potential alternatives to the current depainting methods. The selected alternatives were: 1. Plastic Blast Media 2. Hard Abrasive Media 3. Sponge Blast Media 4. Mechanical Removal with Vacuum Attachment 5. Liquid Nitrogen 6. Laser Coating Removal Available information about these processes was used to analyze the technical merits and the potential environmental, safety, and occupational health (ESOH) impacts of these methods. A preliminary cost benefit analysis will be performed to determine if implementation of alternative technologies is economically justified. NASA AP2

Potential gains from hospital mergers in Denmark.

PubMed

Kristensen, Troels; Bogetoft, Peter; Pedersen, Kjeld Moeller

2010-12-01

The Danish hospital sector faces a major rebuilding program to centralize activity in fewer and larger hospitals. We aim to conduct an efficiency analysis of hospitals and to estimate the potential cost savings from the planned hospital mergers. We use Data Envelopment Analysis (DEA) to estimate a cost frontier. Based on this analysis, we calculate an efficiency score for each hospital and estimate the potential gains from the proposed mergers by comparing individual efficiencies with the efficiency of the combined hospitals. Furthermore, we apply a decomposition algorithm to split merger gains into technical efficiency, size (scale) and harmony (mix) gains. The motivation for this decomposition is that some of the apparent merger gains may actually be available with less than a full-scale merger, e.g., by sharing best practices and reallocating certain resources and tasks. Our results suggest that many hospitals are technically inefficient, and the expected "best practice" hospitals are quite efficient. Also, some mergers do not seem to lower costs. This finding indicates that some merged hospitals become too large and therefore experience diseconomies of scale. Other mergers lead to considerable cost reductions; we find potential gains resulting from learning better practices and the exploitation of economies of scope. To ensure robustness, we conduct a sensitivity analysis using two alternative returns-to-scale assumptions and two alternative estimation approaches. We consistently find potential gains from improving the technical efficiency and the exploitation of economies of scope from mergers.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fisher,D

Concerns about the long-term viability of SFS as the metadata store for HPSS have been increasing. A concern that Transarc may discontinue support for SFS motivates us to consider alternative means to store HPSS metadata. The obvious alternative is a commercial database. Commercial databases have the necessary characteristics for storage of HPSS metadata records. They are robust and scalable and can easily accommodate the volume of data that must be stored. They provide programming interfaces, transactional semantics and a full set of maintenance and performance enhancement tools. A team was organized within the HPSS project to study and recommend anmore » approach for the replacement of SFS. Members of the team are David Fisher, Jim Minton, Donna Mecozzi, Danny Cook, Bart Parliman and Lynn Jones. We examined several possible solutions to the problem of replacing SFS, and recommended on May 22, 2000, in a report to the HPSS Technical and Executive Committees, to change HPSS into a database application over either Oracle or DB2. We recommended either Oracle or DB2 on the basis of market share and technical suitability. Oracle and DB2 are dominant offerings in the market, and it is in the best interest of HPSS to use a major player's product. Both databases provide a suitable programming interface. Transaction management functions, support for multi-threaded clients and data manipulation languages (DML) are available. These findings were supported in meetings held with technical experts from both companies. In both cases, the evidence indicated that either database would provide the features needed to host HPSS.« less

48 CFR 1509.507-2 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... include activities related to technical analyses in determining the nature and extent of contamination at... solicitations and contracts that provide professional architect/engineer, technical, and management services to...) Alternate II shall be used in all Superfund Technical Assistance and Removal Team (START) solicitations and...

Describing Acupuncture: A New Challenge for Technical Communicators.

ERIC Educational Resources Information Center

Karanikas, Marianthe

1997-01-01

Considers acupuncture as an increasingly popular alternative medical therapy, but difficult to describe in technical communication. Notes that traditional Chinese medical explanations of acupuncture are unscientific, and that scientific explanations of acupuncture are inconclusive. Finds that technical communicators must translate acupuncture for…

One-way quantum computing in superconducting circuits

NASA Astrophysics Data System (ADS)

Albarrán-Arriagada, F.; Alvarado Barrios, G.; Sanz, M.; Romero, G.; Lamata, L.; Retamal, J. C.; Solano, E.

2018-03-01

We propose a method for the implementation of one-way quantum computing in superconducting circuits. Measurement-based quantum computing is a universal quantum computation paradigm in which an initial cluster state provides the quantum resource, while the iteration of sequential measurements and local rotations encodes the quantum algorithm. Up to now, technical constraints have limited a scalable approach to this quantum computing alternative. The initial cluster state can be generated with available controlled-phase gates, while the quantum algorithm makes use of high-fidelity readout and coherent feedforward. With current technology, we estimate that quantum algorithms with above 20 qubits may be implemented in the path toward quantum supremacy. Moreover, we propose an alternative initial state with properties of maximal persistence and maximal connectedness, reducing the required resources of one-way quantum computing protocols.

Dual- and Multi-Energy CT: Principles, Technical Approaches, and Clinical Applications

PubMed Central

Leng, Shuai; Yu, Lifeng; Fletcher, Joel G.

2015-01-01

In x-ray computed tomography (CT), materials having different elemental compositions can be represented by identical pixel values on a CT image (ie, CT numbers), depending on the mass density of the material. Thus, the differentiation and classification of different tissue types and contrast agents can be extremely challenging. In dual-energy CT, an additional attenuation measurement is obtained with a second x-ray spectrum (ie, a second “energy”), allowing the differentiation of multiple materials. Alternatively, this allows quantification of the mass density of two or three materials in a mixture with known elemental composition. Recent advances in the use of energy-resolving, photon-counting detectors for CT imaging suggest the ability to acquire data in multiple energy bins, which is expected to further improve the signal-to-noise ratio for material-specific imaging. In this review, the underlying motivation and physical principles of dual- or multi-energy CT are reviewed and each of the current technical approaches is described. In addition, current and evolving clinical applications are introduced. © RSNA, 2015 PMID:26302388

Alternative sample sizes for verification dose experiments and dose audits

NASA Astrophysics Data System (ADS)

Taylor, W. A.; Hansen, J. M.

1999-01-01

ISO 11137 (1995), "Sterilization of Health Care Products—Requirements for Validation and Routine Control—Radiation Sterilization", provides sampling plans for performing initial verification dose experiments and quarterly dose audits. Alternative sampling plans are presented which provide equivalent protection. These sampling plans can significantly reduce the cost of testing. These alternative sampling plans have been included in a draft ISO Technical Report (type 2). This paper examines the rational behind the proposed alternative sampling plans. The protection provided by the current verification and audit sampling plans is first examined. Then methods for identifying equivalent plans are highlighted. Finally, methods for comparing the cost associated with the different plans are provided. This paper includes additional guidance for selecting between the original and alternative sampling plans not included in the technical report.

Reverse Engineering a Signaling Network Using Alternative Inputs

PubMed Central

Tanaka, Hiromasa; Yi, Tau-Mu

2009-01-01

One of the goals of systems biology is to reverse engineer in a comprehensive fashion the arrow diagrams of signal transduction systems. An important tool for ordering pathway components is genetic epistasis analysis, and here we present a strategy termed Alternative Inputs (AIs) to perform systematic epistasis analysis. An alternative input is defined as any genetic manipulation that can activate the signaling pathway instead of the natural input. We introduced the concept of an “AIs-Deletions matrix” that summarizes the outputs of all combinations of alternative inputs and deletions. We developed the theory and algorithms to construct a pairwise relationship graph from the AIs-Deletions matrix capturing both functional ordering (upstream, downstream) and logical relationships (AND, OR), and then interpreting these relationships into a standard arrow diagram. As a proof-of-principle, we applied this methodology to a subset of genes involved in yeast mating signaling. This experimental pilot study highlights the robustness of the approach and important technical challenges. In summary, this research formalizes and extends classical epistasis analysis from linear pathways to more complex networks, facilitating computational analysis and reconstruction of signaling arrow diagrams. PMID:19898612

Evolution of atherectomy devices.

PubMed

Al Khoury, G; Chaer, R

2011-08-01

Percutaneous atherectomy provides an alternative approach to the endovascular treatment of peripheral atherosclerotic occlusive disease beyond angioplasty and stenting, and has the theoretical advantage of lesion debulking and minimizing barotrauma to the vessel wall. Atherectomy has evolved greatly during the last decade, with currently four FDA approved devices for the treatment of peripheral arterial disease. Several reports have focused on the initial technical success rates, and demonstrated the safety and short as well as mid-term efficacy of atherectomy devices. This article will review the evolution of current atherectomy devices and the associated literature.

FBI fingerprint identification automation study. AIDS 3 evaluation report. Volume 2: Technical feasibility

NASA Technical Reports Server (NTRS)

Mulhall, B. D. L.

1980-01-01

The results of this effort are presented in a manner for use by both the AIDS 3 Operational and Economic Feasibility subtasks as well as the Development of Alternative subtask. The approach taken was to identify the major functions that appear in AIDS 3 and then to determine which technologies would be needed for support. The technologies were then examined from the point of view of reliability, throughput, security, availability, cost and possible future trends. Whenever possible graphs are given to indicate projected costs of rapidly changing technologies.

A detailed procedure for the use of small-scale photography in land use classification

NASA Technical Reports Server (NTRS)

Vegas, P. L.

1974-01-01

A procedure developed to produce accurate land use maps from available high-altitude, small-scale photography in a cost-effective manner is presented. An alternative procedure, for use when the capability for updating the resultant land use map is not required, is also presented. The technical approach is discussed in detail, and personnel and equipment needs are analyzed. Accuracy percentages are listed, and costs are cited. The experiment land use classification categories are explained, and a proposed national land use classification system is recommended.

Reconstructing the Soviet National Economic Balance, 1965 - 1984: An Alternative Approach to Estimating Soviet Military Expenditures. Volume 1. Technical Discussion

DTIC Science & Technology

1986-03-11

official Department of Defense position,IA-1 policy, or decision, unless so designated by other official documentation*. DIIO QUA~L~ Lo 0ýi’WD T !C10...least appeared to contain numerous inconsistencies that might be deliberately designed to mislead I Western analysts. Becker’s original assessment of...Construction Works without Collectives 1965-1984 m NK53 Construction Works with Collectives 1965-1984 NK54 Construction Design Works 1965-1984 NK55 Geological

Barriers to Information Transfer and Approaches Toward Their Reduction, Conference Proceedings of the Technical Information Panel Specialists’ Meeting Held in Washington, DC on 23-24 September 1987.

DTIC Science & Technology

1988-03-01

oriented expansion of dictionaries and systems. 4,.j - Portability. Included essential criteria for evaluation are: N - Quality of the raw (also called...hard to be made without having precise criteria for the de- cision. Because the amount of data in computerized dictionaries - on the long line of...develop- ment of MT and CAT systems - is the decisive component, the update of the (electronic) dictionary plays a substantial part in both alternatives

Near-term feasibility of alternative jet fuels

DOT National Transportation Integrated Search

2009-01-01

This technical report documents the results of a joint study by the Massachusetts Institute of Technology (MIT) and the RAND Corporation on alternative fuels for commercial aviation. The study compared potential alternative jet fuels on the basis of ...

ENGINEERING STUDY FOR THE 200 AREA EFFLUENT TREATMENT FACILITY (ETF) SECONDARY WASTE TREATMENT OF PROJECTED FUTURE WASTE FEEDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

LUECK, K.J.

2004-10-18

This report documents an engineering study conducted to evaluate alternatives for treating secondary waste in the secondary treatment train (STT) of the Hanford Site 200 Area Effluent Treatment Facility (ETF). The study evaluates ETF STT treatment alternatives and recommends preferred alternatives for meeting the projected future missions of the ETF. The preferred alternative(s) will process projected future ETF influents to produce a solid waste acceptable for final disposal on the Hanford Site. The main text of this report summarizes the ETF past and projected operations, lists the assumptions about projected operations that provide the basis for the engineering evaluation, andmore » summarizes the evaluation process. The evaluation process includes identification of available modifications to the current ETF process, screens those modifications for technical viability, evaluates the technically viable alternatives, and provides conclusions and recommendations based on that evaluation.« less

The use of carbon dioxide angiography for renal sympathetic denervation: a technical report.

PubMed

Renton, Mary; Hameed, Mohammad A; Dasgupta, Indranil; Hoey, Edward T D; Freedman, Jonathan; Ganeshan, Arul

2016-12-01

Hypertension is the leading attributable cause of cardiovascular mortality worldwide. Patients with hypertension have multiple comorbidities including high rates of concomitant renal disease. Current pharmacological approaches are inadequate in the treatment of resistant hypertension. Renal sympathetic denervation (RDN) has been shown to effectively treat resistant hypertension. The traditional use of iodinated contrast in RDN is contraindicated in patients with significant renal insufficiency. In patients with renal impairment, carbon dioxide (CO 2 ) can be used as an alternative contrast material for RDN. This article describes the technical aspects of RDN using CO 2 angiography. Our centre is experienced in the innovative RDN procedure using CO 2 angiography. We describe the protocol for CO 2 angiography for RDN using a home-made CO 2 delivery system and the Symplicity ™ (Minneapolis MN 55432 USA) catheter (Medtronic) device. CO 2 angiography is an excellent alternative to iodinated contrast for RDN procedures. CO 2 angiography for RDN is a safe and effective alternative to iodinated contrast. RDN using CO 2 angiography is an easy and feasible procedure that can be used in patients with renal insufficiency or iodinated contrast allergies. Advances in knowledge: There is a paucity of descriptive reports for CO 2 angiography for RDN and we provide details of the optimal protocol for the procedure. In particular, we describe the use of a Symplicity Spyral ™ catheter (Medtronic), which has not been reported to date for use in this procedure.

Columbia River System Operation Review : Final Environmental Impact Statement, Appendix N: Wildlife.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Columbia River System Operation Review

1995-11-01

The Columbia River System is a vast and complex combination of Federal and non-Federal facilities used for many purposes including power production, irrigation, navigation, flood control, recreation, fish and wildlife habitat and municipal and industrial water supply. Each river use competes for the limited water resources in the Columbia River Basin. This technical appendix addresses only the effects of alternative system operating strategies for managing the Columbia River system. The environmental impact statement (EIS) itself and some of the other appendices present analyses of the alternative approaches to the other three decisions considered as part of the SOR. This documentmore » is the product of the Wildlife Work Group, focusing on wildlife impacts but not including fishes. Topics covered include the following: scope and process; existing and affected environment, including specific discussion of 18 projects in the Columbia river basin. Analysis, evaluation, and alternatives are presented for all projects. System wide impacts to wildlife are also included.« less

Life cycle thinking and assessment tools on environmentally-benign electronics: Convergent optimization of materials use, end-of-life strategy and environmental policies

NASA Astrophysics Data System (ADS)

Zhou, Xiaoying

The purpose of this study is to integrate the quantitative environmental performance assessment tools and the theory of multi-objective optimization within the boundary of electronic product systems to support the selection among design alternatives in terms of environmental impact, technical criteria, and economic feasibility. To meet with the requirements that result from emerging environmental legislation targeting electronics products, the research addresses an important analytical methodological approach to facilitate environmentally conscious design and end-of-life management with a life cycle viewpoint. A synthesis of diverse assessment tools is applied on a set of case studies: lead-free solder materials selection, cellular phone design, and desktop display technology assessment. In the first part of this work, an in-depth industrial survey of the status and concerns of the U.S. electronics industry on the elimination of lead (Pb) in solders is described. The results show that the trade-offs among environmental consequences, technology challenges, business risks, legislative compliance and stakeholders' preferences must be explicitly, simultaneously, and systematically addressed in the decision-making process used to guide multi-faceted planning of environmental solutions. In the second part of this work, the convergent optimization of the technical cycle, economic cycle and environmental cycle is addressed in a coherent and systematic way using the application of environmentally conscious design of cellular phones. The technical understanding of product structure, components analysis, and materials flow facilitates the development of "Design for Disassembly" guidelines. A bottom-up disassembly analysis on a "bill of materials" based structure at a micro-operational level is utilized to select optimal end-of-life strategies on the basis of economic feasibility. A macro-operational level life cycle model is used to investigate the environmental consequences linking environmental impact with the cellular phone production activities focusing on the upstream manufacturing and end-of-life life cycle stages. The last part of this work, the quantitative elicitation of weighting factors facilitates the comparison of trade-offs in the context of a multi-attribute problem. An integrated analytical approach, Integrated Industrial Ecology Function Deployment (I2-EFD), is proposed to assess alternatives at the design phase of a product system and is validated with the assessment of desktop display technologies and lead-free solder alternatives.

78 FR 48407 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Quality Assurance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... calibration procedures under MIL-T-31000, General Specification for Technical Data Packages, Amendment 1, or MIL-T-47500, General Specification for Technical Data Packages, Supp 1, or drawings and associated... Packages, Amendment 1, or MIL-T-47500, General Specification for Technical Data Packages, Supp 1, or...

SAM Technical Contacts

EPA Pesticide Factsheets

These technical contacts are available to help with questions regarding method deviations, modifications, sample problems or interferences, quality control requirements, the use of alternative methods, or the need to address analytes or sample types.

Potential Applications of Modularity to Enable a Deep Space Habitation Capability for Future Human Exploration Beyond Low-Earth Orbit

NASA Technical Reports Server (NTRS)

Simon, Matthew A.; Toups, Larry; Smitherman, David

2012-01-01

Evaluating preliminary concepts of a Deep Space Habitat (DSH) enabling long duration crewed exploration of asteroids, the Moon, and Mars is a technically challenging problem. Sufficient habitat volumes and equipment, necessary to ensure crew health and functionality, increase propellant requirements and decrease launch flexibility to deliver multiple elements on a single launch vehicle; both of which increase overall mission cost. Applying modularity in the design of the habitat structures and subsystems can alleviate these difficulties by spreading the build-up of the overall habitation capability across several smaller parts. This allows for a more flexible habitation approach that accommodates various crew mission durations and levels of functionality. This paper provides a technical analysis of how various modular habitation approaches can impact the parametric design of a DSH with potential benefits in mass, packaging volume, and architectural flexibility. This includes a description of the desired long duration habitation capability, the definition of a baseline model for comparison, a small trade study to investigate alternatives, and commentary on potentially advantageous configurations to enable different levels of habitability. The approaches investigated include modular pressure vessel strategies, modular subsystems, and modular manufacturing approaches to habitat structure. The paper also comments upon the possibility of an integrated habitation strategy using modular components to create all short and long duration habitation elements required in the current exploration architectures.

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 1. Technical Report #1216

ERIC Educational Resources Information Center

Anderson, Daniel; Park, Jasmine, Bitnara; Lai, Cheng-Fei; Alonzo, Julie; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest/and alternate form) and G-Theory/D-Study research on the easy CBM reading measures, grades 1-5. Data were gathered in the spring 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest. Due…

Trends in Simple Prostatectomy for Benign Prostatic Hyperplasia.

PubMed

Pariser, Joseph J; Packiam, Vignesh T; Adamsky, Melanie A; Bales, Gregory T

2016-08-01

The definitive treatment for symptomatic large volume (>80 mL) benign prostatic hyperplasia (BPH) is simple prostatectomy (SP). This can be performed by utilizing a retropubic, suprapubic, or a combined approach. The latter two approaches allow for the management of concomitant bladder diverticulum or stones through the same incision. Each approach affords unique technical strengths and weaknesses that must be considered in light of patient characteristics and concomitant pathology. SP allows for removal of the entire prostatic adenoma while obviating some of the neurovascular and continence issues that can arise from radical prostatectomy. Concerns with SP include its relatively high perioperative morbidity, notably bleeding. Therefore, there is increasing interest in less invasive options, including enucleation procedures and minimally invasive SP. This review presents an update regarding trends and outcomes of SP, as well as the effectiveness and popularity of alternative treatments.

[Psychotherapy of patients with brain lesions: an integrative model based on neuropsychological and psychodynamic perspectives].

PubMed

Ouss-Ryngaert, Lisa

2010-12-01

Our model of psychotherapy for patients with brain lesions is based on an integrative approach of psychobehavioral symptoms, especially from the neuropsychological and psychodynamic perspectives. Adjustment of technical modalities and aims of psychoanalytical therapy is required for these patients. The analysis of the influence of cognitive disorders on transference and contre-transference plays a major role, including the role of procedural processes in changes in the intersubjective relationship between the patient and the therapist. Two vignettes are presented to illustrate our model, which respects the integrity of the cognitive and psychodynamic approaches and can be implemented by only one therapist, using alternatively each lecture, or by a working team bringing to light the different aspects of the same symptom.

Perceptions of nursing practice in Iran.

PubMed

Nikbakht Nasrabadi, Alireza; Emami, Azita

2006-01-01

It is difficult to clarify the characteristics of the nursing profession and the problems that exist within this field. Gaining an understanding of nurses' perceptions regarding their profession can improve knowledge on this subject. The aim of this qualitative study was to describe the perceptions of Iranian Registered Nurses (IRNs) concerning issues related to their profession. Data were collected from semi-structured interviews with 26 IRNs and analyzed with latent content analysis. Two different but interrelated themes emerged: (1) nursing perceived from an institutional and socio-cultural perspective, and (2) nursing that alternates between a routine medical-technical approach and a caring approach. The findings have implications for nursing practice and education in Iran, and can facilitate changes that could effectively improve the status of nursing in Iran.

Cooperative endeavors: A case study of success

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, J.

1997-12-31

Partnerships and cooperative agreements abound in the environmental arena today. This paper briefly highlights the collaborative approach used by the International Cooperative for Ozone Layer Protection (ICOLP). ICOLP has helped international members and non-members to eliminate most of the ozone-depleting solvents from manufacturing processes through the exchange of technical information in a non-proprietary manner. By using alternatives, companies and governments have realized savings in the multiple millions of dollars. Advantages of participating in cooperative environmental partnerships may include: (1) improved access and exchange of information, (2) cost minimization, (3) promotion and facilitation of business opportunities, (4) improved dialogue between groups,more » (5) coordinated approach to complex issues, and (6) technology development and transfer opportunities.« less

Implantable Systems for Continuous Liquorpheresis and CSF Replacement

PubMed Central

2017-01-01

Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored thus far. Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous technical reports  and provide some new innovations in order to design bidirectional CSF shunting systems that can be complemented either with a deposit of artificial CSF or with a filter of CSF, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF. PMID:28413734

MEGASTAR: The meaning of growth. An assessment of systems, technologies, and requirements. [methodology for display and analysis of energy production and consumption

NASA Technical Reports Server (NTRS)

1974-01-01

A methodology for the display and analysis of postulated energy futures for the United States is presented. A systems approach methodology including the methodology of technology assessment is used to examine three energy scenarios--the Westinghouse Nuclear Electric Economy, the Ford Technical Fix Base Case and a MEGASTAR generated Alternate to the Ford Technical Fix Base Case. The three scenarios represent different paths of energy consumption from the present to the year 2000. Associated with these paths are various mixes of fuels, conversion, distribution, conservation and end-use technologies. MEGASTAR presents the estimated times and unit requirements to supply the fuels, conversion and distribution systems for the postulated end uses for the three scenarios and then estimates the aggregate manpower, materials, and capital requirements needed to develop the energy system described by the particular scenario.

78 FR 36298 - Notice of Intent to Prepare an Environmental Impact Statement for the Federal Way Transit...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

..., and an alternatives analysis study. Early scoping notification for the alternatives analysis phase was... alternatives analysis findings, and other background technical reports are available on the project Web site... about the proposed [[Page 36299

In vivo labeling of cortical astrocytes with sulforhodamine 101 (SR101).

PubMed

Nimmerjahn, Axel; Helmchen, Fritjof

2012-03-01

Fluorescent markers that stain particular cell types in the intact brain are essential tools for fluorescence microscopy because they enable studies of structure and function of cells identified in this way. Although cell type-specific fluorescence staining can be achieved through promoter-driven expression of fluorescent proteins, this genetic approach is generally labor- and cost-intensive. Alternative viral approaches for targeted fluorophore expression are relatively invasive. For astrocytes, there is a simple alternative. This protocol describes an easy and robust method for rapid (within minutes) and high-contrast staining of astrocytes in defined regions of the intact rodent cortex using the synthetic, water-soluble but non-fixable red fluorescent dye sulforhodamine 101 (SR101). Selective staining is achieved through local uptake and gap junction-mediated spread of SR101 following its topical application or injection into tissue. Applications, technical pitfalls, and limitations of the SR101-staining technique are discussed. Given its simplicity and reliability, SR101 staining is a valuable tool for the study of astrocyte function in the intact brain and for in vivo fluorescence microscopy in general.

The quantum computer game: citizen science

NASA Astrophysics Data System (ADS)

Damgaard, Sidse; Mølmer, Klaus; Sherson, Jacob

2013-05-01

Progress in the field of quantum computation is hampered by daunting technical challenges. Here we present an alternative approach to solving these by enlisting the aid of computer players around the world. We have previously examined a quantum computation architecture involving ultracold atoms in optical lattices and strongly focused tweezers of light. In The Quantum Computer Game (see http://www.scienceathome.org/), we have encapsulated the time-dependent Schrödinger equation for the problem in a graphical user interface allowing for easy user input. Players can then search the parameter space with real-time graphical feedback in a game context with a global high-score that rewards short gate times and robustness to experimental errors. The game which is still in a demo version has so far been tried by several hundred players. Extensions of the approach to other models such as Gross-Pitaevskii and Bose-Hubbard are currently under development. The game has also been incorporated into science education at high-school and university level as an alternative method for teaching quantum mechanics. Initial quantitative evaluation results are very positive. AU Ideas Center for Community Driven Research, CODER.

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 2. Technical Report #1217

ERIC Educational Resources Information Center

Anderson, Daniel; Lai, Cheg-Fei; Park, Bitnara Jasmine; Alonzo, Julie; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest an alternate form) and G-Theory/D-Study on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from the convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest. Due to…

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 5. Technical Report #1220

ERIC Educational Resources Information Center

Lai, Cheng-Fei; Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Passage Reading Fluency Assessments: Grade 4. Technical Report #1219

ERIC Educational Resources Information Center

Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Lai, Cheng-Fei; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

Hexavalent IPV-based combination vaccines for public-sector markets of low-resource countries

PubMed Central

Mahmood, Kutub; Pelkowski, Sonia; Atherly, Deborah; Sitrin, Robert; Donnelly, John J

2013-01-01

In anticipation of the successful eradication of wild polio virus, alternative vaccination strategies for public-sector markets of low-resource countries are extremely important, but are still under development. Following polio eradication, inactivated polio vaccine (IPV) would be the only polio vaccine available, and would be needed for early childhood immunization for several years, as maintenance of herd immunity will be important for sustaining polio eradication. Low-cost combination vaccines containing IPV could provide reliable and continuous immunization in the post-polio eradication period. Combination vaccines can potentially simplify complex pediatric routine immunization schedules, improve compliance, and reduce costs. Hexavalent vaccines containing Diphtheria (D), Tetanus (T), whole cell pertussis (wP), Hepatitis B (HBV), Haemophilus b (Hib) and the three IPV serotype antigens have been considered as the ultimate combination vaccine for routine immunization. This product review evaluates potential hexavalent vaccine candidates by composition, probable time to market, expected cost of goods, presentation, and technical feasibility and offers suggestions for development of low-cost hexavalent combination vaccines. Because there are significant technical challenges facing wP-based hexavalent vaccine development, this review also discusses other alternative approaches to hexavalent that could also ensure a timely and reliable supply of low-cost IPV based combination vaccines. PMID:23787559

Hexavalent IPV-based combination vaccines for public-sector markets of low-resource countries.

PubMed

Mahmood, Kutub; Pelkowski, Sonia; Atherly, Deborah; Sitrin, Robert D; Donnelly, John J

2013-09-01

In anticipation of the successful eradication of wild polio virus, alternative vaccination strategies for public-sector markets of low-resource countries are extremely important, but are still under development. Following polio eradication, inactivated polio vaccine (IPV) would be the only polio vaccine available, and would be needed for early childhood immunization for several years, as maintenance of herd immunity will be important for sustaining polio eradication. Low-cost combination vaccines containing IPV could provide reliable and continuous immunization in the post-polio eradication period. Combination vaccines can potentially simplify complex pediatric routine immunization schedules, improve compliance, and reduce costs. Hexavalent vaccines containing Diphtheria (D), Tetanus (T), whole cell pertussis (wP), Hepatitis B (HBV), Haemophilus b (Hib) and the three IPV serotype antigens have been considered as the ultimate combination vaccine for routine immunization. This product review evaluates potential hexavalent vaccine candidates by composition, probable time to market, expected cost of goods, presentation, and technical feasibility and offers suggestions for development of low-cost hexavalent combination vaccines. Because there are significant technical challenges facing wP-based hexavalent vaccine development, this review also discusses other alternative approaches to hexavalent that could also ensure a timely and reliable supply of low-cost IPV based combination vaccines.

Large Scale eHealth Deployment in Europe: Insights from Concurrent Use of Standards.

PubMed

Eichelberg, Marco; Chronaki, Catherine

2016-01-01

Large-scale eHealth deployment projects face a major challenge when called to select the right set of standards and tools to achieve sustainable interoperability in an ecosystem including both legacy systems and new systems reflecting technological trends and progress. There is not a single standard that would cover all needs of an eHealth project, and there is a multitude of overlapping and perhaps competing standards that can be employed to define document formats, terminology, communication protocols mirroring alternative technical approaches and schools of thought. eHealth projects need to respond to the important question of how alternative or inconsistently implemented standards and specifications can be used to ensure practical interoperability and long-term sustainability in large scale eHealth deployment. In the eStandards project, 19 European case studies reporting from R&D and large-scale eHealth deployment and policy projects were analyzed. Although this study is not exhaustive, reflecting on the concepts, standards, and tools for concurrent use and the successes, failures, and lessons learned, this paper offers practical insights on how eHealth deployment projects can make the most of the available eHealth standards and tools and how standards and profile developing organizations can serve the users embracing sustainability and technical innovation.

Crowdsourcing: a valid alternative to expert evaluation of robotic surgery skills.

PubMed

Polin, Michael R; Siddiqui, Nazema Y; Comstock, Bryan A; Hesham, Helai; Brown, Casey; Lendvay, Thomas S; Martino, Martin A

2016-11-01

Robotic-assisted gynecologic surgery is common, but requires unique training. A validated assessment tool for evaluating trainees' robotic surgery skills is Robotic-Objective Structured Assessments of Technical Skills. We sought to assess whether crowdsourcing can be used as an alternative to expert surgical evaluators in scoring Robotic-Objective Structured Assessments of Technical Skills. The Robotic Training Network produced the Robotic-Objective Structured Assessments of Technical Skills, which evaluate trainees across 5 dry lab robotic surgical drills. Robotic-Objective Structured Assessments of Technical Skills were previously validated in a study of 105 participants, where dry lab surgical drills were recorded, de-identified, and scored by 3 expert surgeons using the Robotic-Objective Structured Assessments of Technical Skills checklist. Our methods-comparison study uses these previously obtained recordings and expert surgeon scores. Mean scores per participant from each drill were separated into quartiles. Crowdworkers were trained and calibrated on Robotic-Objective Structured Assessments of Technical Skills scoring using a representative recording of a skilled and novice surgeon. Following this, 3 recordings from each scoring quartile for each drill were randomly selected. Crowdworkers evaluated the randomly selected recordings using Robotic-Objective Structured Assessments of Technical Skills. Linear mixed effects models were used to derive mean crowdsourced ratings for each drill. Pearson correlation coefficients were calculated to assess the correlation between crowdsourced and expert surgeons' ratings. In all, 448 crowdworkers reviewed videos from 60 dry lab drills, and completed a total of 2517 Robotic-Objective Structured Assessments of Technical Skills assessments within 16 hours. Crowdsourced Robotic-Objective Structured Assessments of Technical Skills ratings were highly correlated with expert surgeon ratings across each of the 5 dry lab drills (r ranging from 0.75-0.91). Crowdsourced assessments of recorded dry lab surgical drills using a validated assessment tool are a rapid and suitable alternative to expert surgeon evaluation. Copyright © 2016 Elsevier Inc. All rights reserved.

Analysis of space systems study for the space disposal of nuclear waste study report. Volume 2: Technical report

NASA Technical Reports Server (NTRS)

1981-01-01

Reasonable space systems concepts were systematically identified and defined and a total system was evaluated for the space disposal of nuclear wastes. Areas studied include space destinations, space transportation options, launch site options payload protection approaches, and payload rescue techniques. Systems level cost and performance trades defined four alternative space systems which deliver payloads to the selected 0.85 AU heliocentric orbit destination at least as economically as the reference system without requiring removal of the protective radiation shield container. No concepts significantly less costly than the reference concept were identified.

Outline of cost-benefit analysis and a case study

NASA Technical Reports Server (NTRS)

Kellizy, A.

1978-01-01

The methodology of cost-benefit analysis is reviewed and a case study involving solar cell technology is presented. Emphasis is placed on simplifying the technique in order to permit a technical person not trained in economics to undertake a cost-benefit study comparing alternative approaches to a given problem. The role of economic analysis in management decision making is discussed. In simplifying the methodology it was necessary to restrict the scope and applicability of this report. Additional considerations and constraints are outlined. Examples are worked out to demonstrate the principles. A computer program which performs the computational aspects appears in the appendix.

An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Word and Passage Reading Fluency Assessments: Grade 3. Technical Report #1218

ERIC Educational Resources Information Center

Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Lai, Cheng-Fei; Tindal, Gerald

2012-01-01

This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

Transferring Codified Knowledge: Socio-Technical versus Top-Down Approaches

ERIC Educational Resources Information Center

Guzman, Gustavo; Trivelato, Luiz F.

2008-01-01

Purpose: This paper aims to analyse and evaluate the transfer process of codified knowledge (CK) performed under two different approaches: the "socio-technical" and the "top-down". It is argued that the socio-technical approach supports the transfer of CK better than the top-down approach. Design/methodology/approach: Case study methodology was…

Innovative Approaches to Teaching Technical Communication

ERIC Educational Resources Information Center

Bridgeford, Tracy, Ed.; Kitalong, Karla Saari, Ed.; Selfe, Dickie, Ed.

2004-01-01

"Innovative Approaches to Teaching Technical Communication" offers a variety of activities, projects, and approaches to energize pedagogy in technical communication and to provide a constructive critique of current practice. A practical collection, the approaches recommended here are readily adaptable to a range of technological and institutional…

Urban Transportation Planning Short Course: Evaluation of Alternative Transportation Systems.

ERIC Educational Resources Information Center

Federal Highway Administration (DOT), Washington, DC.

This urban transportation pamphlet delves into the roles of policy groups and technical staffs in evaluating alternative transportation plans, evaluation criteria, systems to evaluate, and evaluation procedures. The introduction admits the importance of subjective, but informed, judgment as an effective tool in weighing alternative transportation…

10 CFR 61.58 - Alternative requirements for waste classification and characteristics.

Code of Federal Regulations, 2014 CFR

2014-01-01

... LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.58 Alternative requirements for waste classification and characteristics. The Commission may, upon request or on... 10 Energy 2 2014-01-01 2014-01-01 false Alternative requirements for waste classification and...

10 CFR 61.58 - Alternative requirements for waste classification and characteristics.

Code of Federal Regulations, 2012 CFR

2012-01-01

... LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.58 Alternative requirements for waste classification and characteristics. The Commission may, upon request or on... 10 Energy 2 2012-01-01 2012-01-01 false Alternative requirements for waste classification and...

10 CFR 61.58 - Alternative requirements for waste classification and characteristics.

Code of Federal Regulations, 2010 CFR

2010-01-01

... LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.58 Alternative requirements for waste classification and characteristics. The Commission may, upon request or on... 10 Energy 2 2010-01-01 2010-01-01 false Alternative requirements for waste classification and...

10 CFR 61.58 - Alternative requirements for waste classification and characteristics.

Code of Federal Regulations, 2013 CFR

2013-01-01

... LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.58 Alternative requirements for waste classification and characteristics. The Commission may, upon request or on... 10 Energy 2 2013-01-01 2013-01-01 false Alternative requirements for waste classification and...

10 CFR 61.58 - Alternative requirements for waste classification and characteristics.

Code of Federal Regulations, 2011 CFR

2011-01-01

... LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.58 Alternative requirements for waste classification and characteristics. The Commission may, upon request or on... 10 Energy 2 2011-01-01 2011-01-01 false Alternative requirements for waste classification and...

25 CFR 30.109 - Will the Secretary provide assistance in developing an alternative AYP definition?

Code of Federal Regulations, 2011 CFR

2011-04-01

... EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.109 Will the... Bureau, shall provide technical assistance either directly or through contract to the tribal governing...

25 CFR 30.109 - Will the Secretary provide assistance in developing an alternative AYP definition?

Code of Federal Regulations, 2010 CFR

2010-04-01

... EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.109 Will the... Bureau, shall provide technical assistance either directly or through contract to the tribal governing...

Radiofrequency ablation of hepatocellular carcinoma: pros and cons.

PubMed

Rhim, Hyunchul; Lim, Hyo K

2010-09-01

Among locoregional treatments for hepatocellular carcinoma (HCC), radiofrequency ablation (RFA) has been accepted as the most popular alternative to curative transplantation or resection, and it shows an excellent local tumor control rate and acceptable morbidity. The benefits of RFA have been universally validated by the practice guidelines of international societies of hepatology. The main advantages of RFA include 1) it is minimally invasive with acceptable morbidity, 2) it enables excellent local tumor control, 3) it has promising long-term survival, and 4) it is a multimodal approach. Based on these pros, RFA will play an important role in managing the patient with early HCC (smaller than 3 cm with fewer than four tumors). The main limitations of current RFA technology in hepatic ablation include 1) limitation of ablation volume, 2) technically infeasible in some tumors due to conspicuity and dangerous location, and 3) the heat-sink effect. Many technical approaches have been introduced to overcome those limitations, including a novel guiding modality, use of artificial fluid or air, and combined treatment strategies. RFA will continue to play a role as a representative ablative modality in the management of HCC, even in the era of targeted agents.

Radiofrequency Ablation of Hepatocellular Carcinoma: Pros and Cons

PubMed Central

Lim, Hyo K.

2010-01-01

Among locoregional treatments for hepatocellular carcinoma (HCC), radiofrequency ablation (RFA) has been accepted as the most popular alternative to curative transplantation or resection, and it shows an excellent local tumor control rate and acceptable morbidity. The benefits of RFA have been universally validated by the practice guidelines of international societies of hepatology. The main advantages of RFA include 1) it is minimally invasive with acceptable morbidity, 2) it enables excellent local tumor control, 3) it has promising long-term survival, and 4) it is a multimodal approach. Based on these pros, RFA will play an important role in managing the patient with early HCC (smaller than 3 cm with fewer than four tumors). The main limitations of current RFA technology in hepatic ablation include 1) limitation of ablation volume, 2) technically infeasible in some tumors due to conspicuity and dangerous location, and 3) the heat-sink effect. Many technical approaches have been introduced to overcome those limitations, including a novel guiding modality, use of artificial fluid or air, and combined treatment strategies. RFA will continue to play a role as a representative ablative modality in the management of HCC, even in the era of targeted agents. PMID:21103289

Treadmill training with partial body weight support after stroke.

PubMed

Hesse, Stefan; Werner, Cordula; von Frankenberg, Sophie; Bardeleben, Anita

2003-02-01

Treadmill therapy with partial BWS is a promising new approach to improve gait ability after stroke. This task-specific approach enables nonambulatory patients the repetitive practice of complex gait cycles instead of single-limb gait-preparatory maneuvers. Patients walk more symmetrically with less spasticity and better cardiovascular efficiency on the treadmill than with floor walking. Several controlled, clinical studies have shown the potential of treadmill training as a therapeutic intervention for nonambulatory patients with chronic stroke-related hemiplegia. Furthermore, controlled trials in acute stroke survivors have shown that treadmill training is as effective as other physiotherapy approaches that stress the repetitive practice of gait. Controlled multicenter trials comparing locomotor training with conventional therapy will be forthcoming. An electromechanical gait trainer that relieves the strenuous effort of the therapists and provides control of the trunk in a phase-dependent manner is a new technical alternative for gait training in severely impaired stroke patients.

Occipital-posterior cerebral artery bypass via the occipital interhemispheric approach

PubMed Central

Kazumata, Ken; Yokoyama, Yuka; Sugiyama, Taku; Asaoka, Katsuyuki

2013-01-01

Background: The unavailability of the superficial temporal artery (STA) and the location of lesions pose a more technically demanding challenge when compared with conventional STA-superior cerebellar or posterior cerebral artery (PCA) bypass in vascular reconstruction procedures. To describe a case series of patients with cerebrovascular lesions who were treated using an occipital artery (OA) to PCA bypass via the occipital interhemispheric approach. Methods: We retrospectively reviewed three consecutive cases of patients with cerebrovascular lesions who were treated using OA-PCA bypass. Results: OA-PCA bypass was performed via the occipital interhemispheric approach. This procedure included: (1) OA-PCA bypass (n = 1), and combined OA-posterior inferior cerebellar artery and OA-PCA saphenous vein interposition graft bypass (n = 1) in patients with vertebrobasilar ischemia; (2) OA-PCA radial artery interposition graft bypass in one patient with residual PCA aneurysm. Conclusions: OA-PCA bypass represents a useful alternative to conventional STA-SCA or PCA bypass. PMID:23956933

Fourier-transform infrared spectroscopy for rapid screening and live-cell monitoring: application to nanotoxicology.

PubMed

Sundaram, S K; Sacksteder, Colette A; Weber, Thomas J; Riley, Brian J; Addleman, R Shane; Harrer, Bruce J; Peterman, John W

2013-01-01

A significant challenge to realize the full potential of nanotechnology for therapeutic and diagnostic applications is to understand and evaluate how live cells interact with an external stimulus, such as a nanosized particle, and the toxicity and broad risk associated with these stimuli. It is difficult to capture the complexity and dynamics of these interactions by following omics-based approaches exclusively, which can be expensive and time-consuming. Attenuated total reflectance-Fourier transform infrared spectroscopy is well suited to provide noninvasive live-cell monitoring of cellular responses to potentially toxic nanosized particles or other stimuli. This alternative approach provides the ability to carry out rapid toxicity screenings and nondisruptive monitoring of live-cell cultures. We review the technical basis of the approach, the instrument configuration and interface with the biological media, the various effects that impact the data, subsequent data analysis and toxicity, and present some preliminary results on live-cell monitoring.

Designing for emotion (among other things)

PubMed Central

Gaver, William

2009-01-01

Using computational approaches to emotion in design appears problematic for a range of technical, cultural and aesthetic reasons. After introducing some of the reasons as to why I am sceptical of such approaches, I describe a prototype we built that tried to address some of these problems, using sensor-based inferencing to comment upon domestic ‘well-being’ in ways that encouraged users to take authority over the emotional judgements offered by the system. Unfortunately, over two iterations we concluded that the prototype we built was a failure. I discuss the possible reasons for this and conclude that many of the problems we found are relevant more generally for designs based on computational approaches to emotion. As an alternative, I advocate a broader view of interaction design in which open-ended designs serve as resources for individual appropriation, and suggest that emotional experiences become one of several outcomes of engaging with them. PMID:19884154

Corrective Action Investigation Plan for Corrective Action Unit 516: Septic Systems and Discharge Points, Nevada Test Site, Nevada, Rev. 0, Including Record of Technical Change No. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This Corrective Action Investigation Plan (CAIP) contains the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Sites Office's (NNSA/NSO's) approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 516, Septic Systems and Discharge Points, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. CAU 516 consists of six Corrective Action Sites: 03-59-01, Building 3C-36 Septic System; 03-59-02, Building 3C-45 Septic System; 06-51-01, Sump Piping, 06-51-02, Clay Pipe and Debris; 06-51-03, Clean Out Box and Piping; and 22-19-04, Vehicle Decontamination Area. Located in Areasmore » 3, 6, and 22 of the NTS, CAU 516 is being investigated because disposed waste may be present without appropriate controls, and hazardous and/or radioactive constituents may be present or migrating at concentrations and locations that could potentially pose a threat to human health and the environment. Existing information and process knowledge on the expected nature and extent of contamination of CAU 516 are insufficient to select preferred corrective action alternatives; therefore, additional information will be obtained by conducting a corrective action investigation. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document. Record of Technical Change No. 1 is dated 3/2004.« less

Investigating the technical adequacy of curriculum-based measurement in written expression for students who are deaf or hard of hearing.

PubMed

Cheng, Shu-Fen; Rose, Susan

2009-01-01

This study investigated the technical adequacy of curriculum-based measures of written expression (CBM-W) in terms of writing prompts and scoring methods for deaf and hard-of-hearing students. Twenty-two students at the secondary school-level completed 3-min essays within two weeks, which were scored for nine existing and alternative curriculum-based measurement (CBM) scoring methods. The technical features of the nine scoring methods were examined for interrater reliability, alternate-form reliability, and criterion-related validity. The existing CBM scoring method--number of correct minus incorrect word sequences--yielded the highest reliability and validity coefficients. The findings from this study support the use of the CBM-W as a reliable and valid tool for assessing general writing proficiency with secondary students who are deaf or hard of hearing. The CBM alternative scoring methods that may serve as additional indicators of written expression include correct subject-verb agreements, correct clauses, and correct morphemes.

Noninvasive Prenatal Detection of Trisomy 21 by Targeted Semiconductor Sequencing: A Technical Feasibility Study.

PubMed

Xi, Yanwei; Arbabi, Aryan; McNaughton, Amy J M; Hamilton, Alison; Hull, Danna; Perras, Helene; Chiu, Tillie; Morrison, Shawna; Goldsmith, Claire; Creede, Emilie; Anger, Gregory J; Honeywell, Christina; Cloutier, Mireille; Macchio, Natasha; Kiss, Courtney; Liu, Xudong; Crocker, Susan; Davies, Gregory A; Brudno, Michael; Armour, Christine M

2017-01-01

To develop an alternate noninvasive prenatal testing method for the assessment of trisomy 21 (T21) using a targeted semiconductor sequencing approach. A customized AmpliSeq panel was designed with 1,067 primer pairs targeting specific regions on chromosomes 21, 18, 13, and others. A total of 235 samples, including 30 affected with T21, were sequenced with an Ion Torrent Proton sequencer, and a method was developed for assessing the probability of fetal aneuploidy via derivation of a risk score. Application of the derived risk score yields a bimodal distribution, with the affected samples clustering near 1.0 and the unaffected near 0. For a risk score cutoff of 0.345, above which all would be considered at "high risk," all 30 T21-positive pregnancies were correctly predicted to be affected, and 199 of the 205 non-T21 samples were correctly predicted. The average hands-on time spent on library preparation and sequencing was 19 h in total, and the average number of reads of sequence obtained was 3.75 million per sample. With the described targeted sequencing approach on the semiconductor platform using a custom-designed library and a probabilistic statistical approach, we have demonstrated the feasibility of an alternate method of assessment for fetal T21. © 2017 S. Karger AG, Basel.

Upper Nasopharyngeal Corridor for Transnasal Endoscopic Drainage of Petroclival Cholesterol Granulomas: Alternative Access in Conchal Sphenoid Patients.

PubMed

Turan, Nefize; Baum, Griffin R; Holland, Christopher M; Ahmad, Faiz U; Henriquez, Oswaldo A; Pradilla, Gustavo

2016-03-01

Background Cholesterol granulomas arising at the petrous apex can be treated via traditional open surgical, endoscopic, and endoscopic-assisted approaches. Endoscopic approaches require access to the sphenoid sinus, which is technically challenging in patients with conchal sphenoidal anatomy. Clinical Presentation A 55-year-old woman presented with intermittent headaches and tinnitus. Formal audiometry demonstrated moderately severe bilateral hearing loss. CT of the temporal bones and sella revealed a well-demarcated expansile lytic mass. MRI of the face, orbit, and neck showed a right petrous apex mass measuring 22 × 18 × 19 mm that was hyperintense on T1- and T2-weighted images without enhancement, consistent with a cholesterol granuloma. The patient had a conchal sphenoidal anatomy. Operative Technique Herein, we present an illustrative case of a low-lying petroclival cholesterol granuloma in a patient with conchal sphenoidal anatomy to describe an alternative high nasopharyngeal corridor for endoscopic transnasal transclival access. Postoperative Course Postoperatively, the patient's symptoms recovered and no complications occurred. Follow-up imaging demonstrated a patent drainage tract without evidence of recurrence. Conclusion In patients with a conchal sphenoid sinus, endoscopic transnasal transclival access can be gained using a high nasopharyngeal approach. This corridor facilitates safe access to these lesions and others in this location.

NextGen Future Safety Assessment Game

NASA Technical Reports Server (NTRS)

Ancel, Ersin; Gheorghe, Adian; Jones, Sharon Monica

2010-01-01

The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

NextGen Future Safety Assessment Game

NASA Technical Reports Server (NTRS)

Ancel, Ersin; Gheorghe, Adrian; Jones, Sharon Monica

2011-01-01

The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

Educational Telecommunications Alternatives for Alaska. Product 1.

ERIC Educational Resources Information Center

Wilke, Jennifer L.; And Others

This study explores a wide variety of technical alternatives, from equipment needs and on-the-ground system design, to equipment operation and suggested applications for department activities, both now and in the future. Some suggested alternatives include (1) communication satellites, (2) one way audio transmission, (3) one and two way hard copy…

Modeling track access charge to enhance railway industry performance

NASA Astrophysics Data System (ADS)

Berawi, Mohammed Ali; Miraj, Perdana; Berawi, Abdur Rohim Boy; Susantono, Bambang; Leviakangas, Pekka; Radiansyah, Hendra

2017-11-01

Indonesia attempts to improve nation's competitiveness by increasing the quality and the availability of railway network. However, the infrastructure improperly managed by the operator in terms of the technical issue. One of the reasons for this problem is an unbalanced value of infrastructure charge. In 2000's track access charge and infrastructure maintenance and operation for Indonesia railways are equal and despite current formula of the infrastructure charge, issues of transparency and accountability still in question. This research aims to produce an alternative scheme of track access charge by considering marginal cost plus markup (MC+) approach. The research combines qualitative and quantitative method through an in-depth interview and financial analysis. The result will generate alternative formula of infrastructure charge in Indonesia's railway industry. The simulation also conducted to estimate track access charge for the operator and to forecast government support in terms of subsidy. The result is expected to enhance railway industry performance and competitiveness.

Surveillance alternatives : cost estimates and technical considerations for the en route domain

DOT National Transportation Integrated Search

1998-09-01

The report present cost estimates and technical performance projections for ten aircraft surveillance architectures. The architectures are intended for use in the en route flight domain, and are comprised of various combinations of Automatic Dependen...

75 FR 44968 - Office of the Secretary, Office of the Assistant Secretary for Planning and Evaluation; Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-30

... Trustees) establish a panel of technical experts to review the methods used in the HI and SMI annual... care, and alternate projection methodologies. The panel may also examine other methodological issues...

Mobilization and Defense Management Technical Reports Series. Alternative Service for Conscientious Objectors.

DTIC Science & Technology

1983-03-01

THIS STUDY EXAMINES THE DIFFERENCE BETWEEN THE SELECTIVE SERVICE SYSTEM’S (SSS) CONCEPT OF ALTERNATIVE SERVICE AND THOSE ESPOUSED BY THE MENNONITE CHURCH...System’s (SSS) concept of Alternative Service and those espoused by the Mnnonite Church, the most articulate opponent of current administration planning...adminisrat-ion of an alternative service program. on January 22, the SSS puiblished its proposed concept for alternative service in the Federal Register and

Novel multiregion hybridization assay for the identification of the most prevalent genetic forms of the human immunodeficiency virus type 1 circulating in Portugal.

PubMed

Freitas, Ferdinando B; Esteves, Aida; Piedade, João; Parreira, Ricardo

2013-02-01

The most efficient method for HIV-1 genetic characterization involves full-genome sequencing, but the associated costs, technical features, and low throughput preclude it from being routinely used for the analysis of large numbers of viral strains. Multiregion hybridization assays (MHA) represent an alternative for a consistent genetic analysis of large numbers of viral strains. Classically, MHA rely on the amplification by real-time PCR of several regions scattered along the HIV-1 genome, and on their characterization with clade-specific TaqMan probes (also known as hydrolysis probes). In this context, the aim of our study was the development of a technical variant of an MHA (vMHA(B/G/02)) for genotyping the most prevalent genetic forms of HIV-1 circulating in Portugal. Different sets of primers were designed for universal and clade-specific amplifications of several sections of the viral genome: gag, pol(Pr), pol(RT), vpu, env(gp120), and env(gp41). vMHA(B/G/02) was implemented using a real-time PCR-based approach, with detection dependent on the use of SYBR Green I. As an alternative, a technically less demanding strategy based on conventional PCR and agarose gel analysis of the reaction products was also developed. This method performed with overall good sensitivity and specificity (>91%) when a convenience sample of 45 plasma-derived HIV-1 strains was analyzed. Apart from the detection of subtype B, G, CRF02_AG, and CRF14_BG viruses, several unique B/G recombinant were also detected. Curiously, recombinant viruses including CRF02_AG sequences were not detected in the group of samples analyzed.

10 CFR 504.6 - Prohibitions by order (case-by-case).

Code of Federal Regulations, 2013 CFR

2013-01-01

... had, the technical capability to use an alternate fuel as a primary energy source; (2) The unit has... (3) It is financially feasible for the unit to use an alternate fuel as its primary energy source. (b... Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS § 504.6 Prohibitions by...

10 CFR 504.6 - Prohibitions by order (case-by-case).

Code of Federal Regulations, 2014 CFR

2014-01-01

... had, the technical capability to use an alternate fuel as a primary energy source; (2) The unit has... (3) It is financially feasible for the unit to use an alternate fuel as its primary energy source. (b... Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS § 504.6 Prohibitions by...

10 CFR 504.6 - Prohibitions by order (case-by-case).

Code of Federal Regulations, 2012 CFR

2012-01-01

... had, the technical capability to use an alternate fuel as a primary energy source; (2) The unit has... (3) It is financially feasible for the unit to use an alternate fuel as its primary energy source. (b... Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS § 504.6 Prohibitions by...

10 CFR 504.6 - Prohibitions by order (case-by-case).

Code of Federal Regulations, 2011 CFR

2011-01-01

... had, the technical capability to use an alternate fuel as a primary energy source; (2) The unit has... (3) It is financially feasible for the unit to use an alternate fuel as its primary energy source. (b... Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS § 504.6 Prohibitions by...

Sliding to predict: vision-based beating heart motion estimation by modeling temporal interactions.

PubMed

Aviles-Rivero, Angelica I; Alsaleh, Samar M; Casals, Alicia

2018-03-01

Technical advancements have been part of modern medical solutions as they promote better surgical alternatives that serve to the benefit of patients. Particularly with cardiovascular surgeries, robotic surgical systems enable surgeons to perform delicate procedures on a beating heart, avoiding the complications of cardiac arrest. This advantage comes with the price of having to deal with a dynamic target which presents technical challenges for the surgical system. In this work, we propose a solution for cardiac motion estimation. Our estimation approach uses a variational framework that guarantees preservation of the complex anatomy of the heart. An advantage of our approach is that it takes into account different disturbances, such as specular reflections and occlusion events. This is achieved by performing a preprocessing step that eliminates the specular highlights and a predicting step, based on a conditional restricted Boltzmann machine, that recovers missing information caused by partial occlusions. We carried out exhaustive experimentations on two datasets, one from a phantom and the other from an in vivo procedure. The results show that our visual approach reaches an average minima in the order of magnitude of [Formula: see text] while preserving the heart's anatomical structure and providing stable values for the Jacobian determinant ranging from 0.917 to 1.015. We also show that our specular elimination approach reaches an accuracy of 99% compared to a ground truth. In terms of prediction, our approach compared favorably against two well-known predictors, NARX and EKF, giving the lowest average RMSE of 0.071. Our approach avoids the risks of using mechanical stabilizers and can also be effective for acquiring the motion of organs other than the heart, such as the lung or other deformable objects.

Improving Secondary Career and Technical Education through Professional Development: Alternative Certification and Use of Technical Assessment Data

ERIC Educational Resources Information Center

National Research Center for Career and Technical Education, 2011

2011-01-01

Secondary career and technical education (CTE) is a field in transition. It is moving from a primary focus on preparing students for entry-level employment to preparing them for continuing education and training as well as employment. The rapid pace of change in technology and the global economy has created a demand for workers who are able to…

Implications of Metaphors in Defining Technical Communication.

ERIC Educational Resources Information Center

Beck, Charles E.

1991-01-01

Identifies four metaphors that appear dominant in current studies in the field of technical communication: transmitter, channel, balance, and bridge. Suggests limitations upon each of the metaphors. Discusses the alternative metaphors of lock, translator, transformer, synthesizer, conductor, and orchestrator. Proposes orchestration as a fruitful…

Advanced transportation system studies technical area 3: Alternate propulsion subsystem concepts, volume 3

NASA Technical Reports Server (NTRS)

Levak, Daniel

1993-01-01

The objective of this contract was to provide definition of alternate propulsion systems for both earth-to-orbit (ETO) and in-space vehicles (upper stages and space transfer vehicles). For such propulsion systems, technical data to describe performance, weight, dimensions, etc. was provided along with programmatic information such as cost, schedule, needed facilities, etc. Advanced technology and advanced development needs were determined and provided. This volume separately presents the various program cost estimates that were generated under three tasks: the F-1A Restart Task, the J-2S Restart Task, and the SSME Upper Stage Use Task. The conclusions, technical results, and the program cost estimates are described in more detail in Volume 1 - Executive Summary and in individual Final Task Reports.

Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystems Concepts. Volume 3; Program Cost Estimates

NASA Technical Reports Server (NTRS)

Levack, Daniel J. H.

2000-01-01

The objective of this contract was to provide definition of alternate propulsion systems for both earth-to-orbit (ETO) and in-space vehicles (upper stages and space transfer vehicles). For such propulsion systems, technical data to describe performance, weight, dimensions, etc. was provided along with programmatic information such as cost, schedule, needed facilities, etc. Advanced technology and advanced development needs were determined and provided. This volume separately presents the various program cost estimates that were generated under three tasks: the F- IA Restart Task, the J-2S Restart Task, and the SSME Upper Stage Use Task. The conclusions, technical results , and the program cost estimates are described in more detail in Volume I - Executive Summary and in individual Final Task Reports.

Modeling of technical soil-erosion control measures and its impact on soil erosion off-site effects within urban areas

NASA Astrophysics Data System (ADS)

Dostal, Tomas; Devaty, Jan

2013-04-01

The paper presents results of surface runoff, soil erosion and sediment transport modeling using Erosion 3D software - physically based mathematical simulation model, event oriented, fully distributed. Various methods to simulate technical soil-erosion conservation measures were tested, using alternative digital elevation models of different precision and resolution. Ditches and baulks were simulated by three different approaches, (i) by change of the land-cover parameters to increase infiltration and decrease flow velocity, (ii) by change of the land-cover parameters to completely infiltrate the surface runoff and (iii) by adjusting the height of the digital elevation model by "burning in" the channels of the ditches. Results show advantages and disadvantages of each approach and conclude suitable methods for combinations of particular digital elevation model and purpose of the simulations. Further on a set of simulations was carried out to model situations before and after technical soil-erosion conservation measures application within a small catchment of 4 km2. These simulations were focused on quantitative and qualitative assessment of technical soil-erosion control measures impact on soil erosion off-site effects within urban areas located downstream of intensively used agricultural fields. The scenarios were built upon a raster digital elevation model with spatial resolution of 3 meters derived from LiDAR 5G vector point elevation data. Use of this high-resolution elevation model allowed simulating the technical soil-erosion control measures by direct terrain elevation adjustment. Also the structures within the settlements were emulated by direct change in the elevation of the terrain model. The buildings were lifted up to simulate complicated flow behavior of the surface runoff within urban areas, using approach of Arévalo (Arévalo, 2011) but focusing on the use of commonly available data without extensive detailed editing. Application of the technical soil-erosion control measures induced strong change in overall amount of eroded/deposited material as well as spatial erosion/deposition patterns within the settlement areas. Validation of modeled scenarios and effects on measured data was not possible as no real runoff event was recorded in the target area so the conclusions were made by comparing the different modeled scenarios. Advantages and disadvantages of used approach to simulate technical soil-erosion conservation measures are evaluated and discussed as well as the impact of use of high-resolution elevation data on the intensity and spatial distribution of soil erosion and deposition. Model approved ability to show detailed distribution of damages over target urban area, which is very sensitive for off-site effects of surface runoff, soil erosion and sediment transport and also high sensitivity to input data, especially to DEM, which affects surface runoff pattern and therefore intensity of harmful effects. Acknowledgement: This paper has been supported by projects: Ministry of the interior of the CR VG 20122015092, and project NAZV QI91C008 TPEO.

Distributed deep learning networks among institutions for medical imaging.

PubMed

Chang, Ken; Balachandar, Niranjan; Lam, Carson; Yi, Darvin; Brown, James; Beers, Andrew; Rosen, Bruce; Rubin, Daniel L; Kalpathy-Cramer, Jayashree

2018-03-29

Deep learning has become a promising approach for automated support for clinical diagnosis. When medical data samples are limited, collaboration among multiple institutions is necessary to achieve high algorithm performance. However, sharing patient data often has limitations due to technical, legal, or ethical concerns. In this study, we propose methods of distributing deep learning models as an attractive alternative to sharing patient data. We simulate the distribution of deep learning models across 4 institutions using various training heuristics and compare the results with a deep learning model trained on centrally hosted patient data. The training heuristics investigated include ensembling single institution models, single weight transfer, and cyclical weight transfer. We evaluated these approaches for image classification in 3 independent image collections (retinal fundus photos, mammography, and ImageNet). We find that cyclical weight transfer resulted in a performance that was comparable to that of centrally hosted patient data. We also found that there is an improvement in the performance of cyclical weight transfer heuristic with a high frequency of weight transfer. We show that distributing deep learning models is an effective alternative to sharing patient data. This finding has implications for any collaborative deep learning study.

Energy from wood waste - A case study

NASA Technical Reports Server (NTRS)

Scola, R.; Daughtrey, K.

1980-01-01

A joint study has been conducted by NASA and Army installations collocated in a dense forest in southwestern Mississippi in order to determine the technical and economic feasibility of using wood waste as a renewable energy source. The study has shown that, with proper forest management, the timber on government lands could eventually support the total energy requirements of 832 billion Btu/yr. Analysis of the current conversion technologies indicates that the direct combustion spreader stoker approach is the best demonstrated technology for this specific application. The economics of the individual powerplants reveal them as attractive alternatives to fossil fueled plants. Environmental aspects are also discussed.

A critical analysis towards research perspectives: Reply to comments on "Modeling human behavior in economics and social science".

PubMed

Dolfin, M; Leonida, L; Outada, N

2017-12-01

We take advantage of the challenging comments to the modeling approach we proposed in [35] to look ahead at a number of applications of the methods to the alternative questions these comments raise. In turn, our effort results in a number of interesting and valuable research perspectives. The presentation goes along three main lines. In the first line, we summarize briefly the aims and results in [35]. In the second section we give a technical the issues raised and, finally, the focus moves to the above mentioned research perspectives. Copyright © 2017 Elsevier B.V. All rights reserved.

Transient Inverse Calibration of Hanford Site-Wide Groundwater Model to Hanford Operational Impacts - 1943 to 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cole, Charles R.; Bergeron, Marcel P.; Wurstner, Signe K.

2001-05-31

This report describes a new initiative to strengthen the technical defensibility of predictions made with the Hanford site-wide groundwater flow and transport model. The focus is on characterizing major uncertainties in the current model. PNNL will develop and implement a calibration approach and methodology that can be used to evaluate alternative conceptual models of the Hanford aquifer system. The calibration process will involve a three-dimensional transient inverse calibration of each numerical model to historical observations of hydraulic and water quality impacts to the unconfined aquifer system from Hanford operations since the mid-1940s.

State recommendations on approaches to LANDSAT

NASA Technical Reports Server (NTRS)

Bay, S. M.; Wubker, P.

1977-01-01

The feasibility of continuing the LANDSAT program is contingent upon the success of the technology transfer process to state and local governments. The focus of these concerns can be generally expressed in terms of these issue areas: (1) user needs, in terms of awareness, technical capabilities, and training; (2) product availability and pricing; and (3) roles and communication links, in terms of federal and state governments, the private sector, and the universities. The perspective of the states on these issues are classified. Where possible, alternative strategies for accomplishing the satellite technology transfer for effective state implementation are suggested. Those suggestions are based on the recommendations offered by the state and local user community.

Lunar mission safety and rescue: Escape/rescue analysis and plan

NASA Technical Reports Server (NTRS)

1971-01-01

The results are presented of the technical analysis of escape/rescue/survival situations, crew survival techniques, alternate escape/rescue approaches and vehicles, and the advantages and disadvantages of each for advanced lunar exploration. Candidate escape/rescue guidelines are proposed and elements of a rescue plan developed. The areas of discussions include the following: lunar arrival/departure operations, lunar orbiter operations, lunar surface operations, lunar surface base escape/rescue analysis, lander tug location operations, portable airlock, emergency pressure suit, and the effects of no orbiting lunar station, no lunar surface base, and no foreign lunar orbit/surface operations on the escape/rescue plan.

Metal Oxides and Ion-Exchanging Surfaces as pH Sensors in Liquids: State-of-the-Art and Outlook

PubMed Central

Kurzweil, Peter

2009-01-01

Novel applications of online pH determinations at temperatures from -35 °C to 130 °C in technical and biological media, which are all but ideal aqueous solutions, require new approaches to pH monitoring. The glass electrode, introduced nearly hundred years ago, and chemical sensors based on field effect transistors (ISFET) show specific drawbacks with respect to handling and long-time stability. Proton sensitive metal oxides seem to be a promising and alternative to the state-of-the-art measuring methods, and might overcome some problems of classical hydrogen electrodes and reference electrodes. PMID:22408563

Community-based livestock breeding programmes: essentials and examples.

PubMed

Mueller, J P; Rischkowsky, B; Haile, A; Philipsson, J; Mwai, O; Besbes, B; Valle Zárate, A; Tibbo, M; Mirkena, T; Duguma, G; Sölkner, J; Wurzinger, M

2015-04-01

Breeding programmes described as community-based (CBBP) typically relate to low-input systems with farmers having a common interest to improve and share their genetic resources. CBBPs are more frequent with keepers of small ruminants, in particular smallholders of local breeds, than with cattle, pigs or chickens with which farmers may have easier access to alternative programmes. Constraints that limit the adoption of conventional breeding technologies in low-input systems cover a range of organizational and technical aspects. The analysis of 8 CBBPs located in countries of Latin-America, Africa and Asia highlights the importance of bottom-up approaches and involvement of local institutions in the planning and implementation stages. The analysis also reveals a high dependence of these programmes on organizational, technical and financial support. Completely self-sustained CBBPs seem to be difficult to realize. There is a need to implement and document formal socio-economic evaluations of CBBPs to provide governments and other development agencies with the information necessary for creating sustainable CBBPs at larger scales. © 2015 Blackwell Verlag GmbH.

The Role of Laparoscopic-Assisted Myomectomy (LAM)

PubMed Central

Nezhat, Ceana H.; Nezhat, Farr.; Nezhat, Camran

2001-01-01

Laparoscopic myomectomy has recently gained wide acceptance. However, this procedure remains technically highly demanding and concerns have been raised regarding the prolonged time of anesthesia, increased blood loss, and possibly a higher risk of postoperative adhesion formation. Laparoscopic-assisted myomectomy (LAM) is advocated as a technique that may lessen these concerns regarding laparoscopic myomectomy while retaining the benefits of laparoscopic surgery, namely, short hospital stay, lower costs, and rapid recovery. By decreasing the technical demands, and thereby the operative time, LAM may be more widely offered to patients. In carefully selected cases, LAM is a safe and efficient alternative to both laparoscopic myomectomy and myomectomy by laparotomy. These cases include patients with numerous large or deep intramural myomas. LAM allows easier repair of the uterus and rapid morcellation of the myomas. In women who desire a future pregnancy, LAM may be a better approach because it allows meticulous suturing of the uterine defect in layers and thereby eliminates excessive electrocoagulation. PMID:11719974

Health systems: changes in hospital efficiency and profitability.

PubMed

Büchner, Vera Antonia; Hinz, Vera; Schreyögg, Jonas

2016-06-01

This study investigates potential changes in hospital performance after health system entry, while differentiating between hospital technical and cost efficiency and hospital profitability. In the first stage we obtained (bootstrapped) data envelopment analysis (DEA) efficiency scores. Then, genetic matching is used as a novel matching procedure in this context along with a difference-in-difference approach within a panel regression framework. With the genetic matching procedure, independent and health system hospitals are matched along a number of environmental and organizational characteristics. The results show that health system entry increases hospital technical and cost efficiency by between 0.6 and 3.4 % in four alternative post-entry periods, indicating that health system entry has not a transitory but rather a permanent effect on hospital efficiency. Regarding hospital profitability, the results reveal an increase in hospital profitability only 1 year after health system entry, and the estimations suggest that this effect is a transitional phenomenon. Overall, health system entry may serve as an appropriate management instrument for decision makers to increase hospital performance.

Inhaled phage therapy: a promising and challenging approach to treat bacterial respiratory infections.

PubMed

Bodier-Montagutelli, Elsa; Morello, Eric; L'Hostis, Guillaume; Guillon, Antoine; Dalloneau, Emilie; Respaud, Renaud; Pallaoro, Nikita; Blois, Hélène; Vecellio, Laurent; Gabard, Jérôme; Heuzé-Vourc'h, Nathalie

2017-08-01

Bacterial respiratory tract infections (RTIs) are increasingly difficult to treat due to evolving antibiotic resistance. In this context, bacteriophages (or phages) are part of the foreseen alternatives or combination therapies. Delivering phages through the airways seems more relevant to accumulate these natural antibacterial viruses in proximity to their bacterial host, within the infectious site. Areas covered: This review addresses the potential of phage therapy to treat RTIs and discusses preclinical and clinical results of phages administration in this context. Recent phage formulation and aerosolization attempts are also reviewed, raising technical challenges to achieve efficient pulmonary deposition via inhalation. Expert opinion: Overall, the inhalation of phages as antibacterial treatment seems both clinically relevant and technically feasible. Several crucial points still need to be investigated, such as phage product pharmacokinetics and immunogenicity. Furthermore, given phage-specific features, appropriate regulatory and manufacturing guidelines will need to be defined. Finally, randomized controlled clinical trials should be carried out to establish phage therapy's clinical positioning in the antimicrobial arsenal against RTIs.

MEGASTAR: The Meaning of Energy Growth: An Assessment of Systems, Technologies, and Requirements

NASA Technical Reports Server (NTRS)

1974-01-01

A methodology for the display and analysis of postulated energy futures for the United States is presented. A systems approach that includes the methodology of technology assessment is used to examine three energy scenarios--the Westinghouse Nuclear Electric Economy, the Ford Technical Fix Base Case and a MEGASTAR generated Alternate to the Ford Technical Fix Base Case. The three scenarios represent different paths of energy consumption for the present to the year 2000. Associated with these paths are various mixes of fuels, conversion, distribution, conservation and end-use technologies. MEGASTAR presents the estimated times and unit requirements to supply the fuels, conversion and distribution systems for the postulated end uses for the three scenarios and then estimates the aggregate manpower, materials, and capital requirements needed to develop the energy system described by the particular scenario. The total requirements and the energy subsystems for each scenario are assessed for their primary impacts in the areas of society, the environment, technology and the economy.

ALTERNATIVE ENERGY SOURCES FOR WASTEWATER TREATMENT PLANTS

EPA Science Inventory

The technology assessment provides an introduction to the use of several alternative energy sources at wastewater treatment plants. The report contains fact sheets (technical descriptions) and data sheets (cost and design information) for the technologies. Cost figures and schema...

44 CFR 67.6 - Basis of appeal.

Code of Federal Regulations, 2014 CFR

2014-10-01

... technically incorrect. Because scientific and technical correctness is often a matter of degree rather than...), appellants are required to demonstrate that alternative methods or applications result in more correct... due to error in application of hydrologic, hydraulic or other methods or use of inferior data in...

44 CFR 67.6 - Basis of appeal.

Code of Federal Regulations, 2012 CFR

2012-10-01

... technically incorrect. Because scientific and technical correctness is often a matter of degree rather than...), appellants are required to demonstrate that alternative methods or applications result in more correct... due to error in application of hydrologic, hydraulic or other methods or use of inferior data in...

44 CFR 67.6 - Basis of appeal.

Code of Federal Regulations, 2013 CFR

2013-10-01

... technically incorrect. Because scientific and technical correctness is often a matter of degree rather than...), appellants are required to demonstrate that alternative methods or applications result in more correct... due to error in application of hydrologic, hydraulic or other methods or use of inferior data in...

44 CFR 67.6 - Basis of appeal.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technically incorrect. Because scientific and technical correctness is often a matter of degree rather than...), appellants are required to demonstrate that alternative methods or applications result in more correct... due to error in application of hydrologic, hydraulic or other methods or use of inferior data in...

78 FR 46546 - Design-Build Contracting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

...-0043] RIN 2125-AF58 Design-Build Contracting AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... alternative technical concepts (ATC) in design-build project delivery of highway construction. The revisions... design-build proposers to submit ATCs in their technical and price proposals. The FHWA seeks comments on...

Evolving Jobs and Nonteaching Professional Staff in Universities: An Alternative Perspective on Career Mobility Processes. Final Project Report.

ERIC Educational Resources Information Center

Estler, Suzanne E.

Three technical reports and abstracts of colloquium papers are presented as part of a research project concerning the specification and testing of alternative models of intraorganizational career mobility among nonteaching professionals in universities. This project phase involved: the development of a model of evolving jobs as an alternative to…

Professional Development Experiences of Alternatively Certified Career and Technical Education Teachers in North Carolina

ERIC Educational Resources Information Center

Welfare, Rhonda Marie

2013-01-01

In an effort to increase the quantity and quality of available teachers, states have begun to offer alternate methods of teacher certification. This means that in addition to traditional teacher training, which involves graduation from an accredited teacher-education institution, states provide alternate routes to enable teachers to transition to…

Inference by Exclusion in Goffin Cockatoos (Cacatua goffini)

PubMed Central

O’Hara, Mark; Auersperg, Alice M. I.; Bugnyar, Thomas; Huber, Ludwig

2015-01-01

Inference by exclusion, the ability to base choices on the systematic exclusion of alternatives, has been studied in many nonhuman species over the past decade. However, the majority of methodologies employed so far are hard to integrate into a comparative framework as they rarely use controls for the effect of neophilia. Here, we present an improved approach that takes neophilia into account, using an abstract two-choice task on a touch screen, which is equally feasible for a large variety of species. To test this approach we chose Goffin cockatoos (Cacatua goffini), a highly explorative Indonesian parrot species, which have recently been reported to have sophisticated cognitive skills in the technical domain. Our results indicate that Goffin cockatoos are able to solve such abstract two-choice tasks employing inference by exclusion but also highlight the importance of other response strategies. PMID:26244692

Funding California Schools: The Revenue Limit System. Technical Appendices

ERIC Educational Resources Information Center

Weston, Margaret

2010-01-01

This document presents the technical appendices accompanying the report, "Funding California Schools: The Revenue Limit System." Included are: (1) Revenue Limit Calculation and Decomposition; (2) Data and Methods; and (3) Base Funding Alternative Simulation Results. (Contains 5 tables and 26 footnotes.) [For the main report,…

Amplification in Technical Manuals: Theory and Practice.

ERIC Educational Resources Information Center

Killingsworth, M. Jimmie; And Others

1989-01-01

Examines how amplification (rhetorical techniques by which discourse is extended to enhance its appeal and information value) tends to increase and improve the coverage, rationale, warnings, behavioral alternatives, examples, previews, and general emphasis of technical manuals. Shows how classical and modern rhetorical theories can be applied to…

TECHNICAL RESOURCE DOCUMENT: TREATMENT TECHNOLOGIES FOR CORROSIVE-CONTAINING WASTES. VOLUME 2

EPA Science Inventory

The Technical Resource Document (TRD) for wastes containing corrosives is one in a series of five documents which evaluate waste management alternatives to land disposal. In addition to this TRD for corrosive wastes, the other four TRDs in the series address land disposal alterna...

Pathways for School Finance in California. Technical Appendix

ERIC Educational Resources Information Center

Rose, Heather; Sonstelie, Jon; Weston, Margaret

2010-01-01

This is a technical appendix for the report, "Pathways for School Finance in California" (ED515651). "Pathways for School Finance in California" simulates alternatives to California's current school finance system. This appendix provides more information about the revenues used in those simulations. The first section describes…

Stirling engine alternatives for the terrestrial solar application

NASA Technical Reports Server (NTRS)

Stearns, J.

1985-01-01

The first phase of the present study of Stirling engine alternatives for solar thermal-electric generation has been completed. Development risk levels are considered to be high for all engines evaluated. Free-piston type and Ringbom-type Stirling engine-alternators are not yet developed for the 25 to 50-kW electrical power range, although smaller machines have demonstrated the inherent robustness of the machines. Kinematic-type Stirling engines are presently achieving a 3500 hr lifetime or longer on critical components, and lifetime must still be further extended for the solar application. Operational and technical characteristics of all types of Stirling engines have been reviewed with engine developers. Technical work of merit in progress in each engine development organization should be recognized and supported in an appropriate manner.

Fully laparoscopic left hepatectomy - a technical reference proposed for standard practice compared to the open approach: a retrospective propensity score model.

PubMed

Valente, Roberto; Sutcliffe, Robert; Levesque, Eric; Costa, Mara; De' Angelis, Nicola; Tayar, Claude; Cherqui, Daniel; Laurent, Alexis

2018-04-01

Laparoscopic left hemihepatectomy (LLH) may be an alternative to open (OLH). There are several original variations in the technical aspects of LLH, and no accepted standard. The aim of this study is to assess the safety and effectiveness of the technique developed at Henri Mondor Hospital since 1996. The technique of LLH was conceived for safety and training of two mature generations of lead surgeons. The technique includes full laparoscopy, ventral approach to the common trunk, extrahepatic pedicle dissection, CUSA ® parenchymal transection, division of the left hilar plate laterally to the Arantius ligament, and ventral transection of the left hepatic vein. The outcomes of LLH and OLH were compared. Perioperative analysis included intra- and postoperative, and histology variables. Propensity Score Matching was undertaken of background covariates including age, ASA, BMI, fibrosis, steatosis, tumour size, and specimen weight. 17 LLH and 51 OLH were performed from 1996 to 2014 with perioperative mortality rates of 0% and 6%, respectively. In the LLH group, two patients underwent conversion to open surgery. Propensity matching selected 10 LLH/OLH pairs. The LLH group had a higher proportion of procedures for benign disease. LLH was associated with longer operating time and less blood loss. Perioperative complications occurred in 30% (LLH) and 10% (OLH) (p = 1). Mortality and ITU stay were similar. This technique is recommended as a possible technical reference for standard LLH. Copyright © 2017 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

Socio-economic Evaluation Of Different Alternatives For Flood Protection Within The Rivierenland-project

NASA Astrophysics Data System (ADS)

Boot, S. P.; van Ast, J. A.

The Netherlands have a tradition of protecting land against flooding from the main rivers Rhine, Meuse and Scheldt by means of an extensive system of dikes. In recent years, however, this approach to protection has been increasingly questioned with re- gard to its sustainability and cost-effectiveness. The argument is that although the continued elevation of dikes may be technically feasible, there are several disadvan- tages to this approach. Firstly, a vast network of dikes requires a very high degree of organisation of water management, in which mistakes can not be afforded. Such a high degree of organisation may not always be maintainable in the future, due to changed economic or political circumstances. Secondly, it may not be the most cost- effective system for maintaining safety in the long term. Thirdly, it may not be the most desirable approach in terms of sustainability. One of the alternatives to contin- ued dike-elevation is the concept 'room for the river' ('ruimte voor de rivier'), which aims to give more space to rivers in the horizontal in stead of the vertical dimen- sion. This approach would reduce the risk of flooding, defined as the product of the probability and the consequences of flooding. In order to explore the long term con- sequences of both alternatives ('dike elevation' and 'room for the river'), the ministry of Verkeer en Waterstaat (Public Works, Transport and Water Management) started the 'Rivierenland'-project. The comparison of the alternatives mentioned was based on a fictitious project to adjust a region of The Netherlands, between the rivers Rhine and Meuse, to the concept of 'room for water'. The consequence of this adjustment would be that safety within that region would no longer be safeguarded by dikes, but by adjusting daily life to the 'demands of the water'. Part of the 'Rivierenland'-project was an analysis of the socio-economic costs and benefits of the alternative approaches. Within this analysis, a study was performed to identify the requirements an economic evaluation of the project-alternatives would have to meet to do justice to the specific characteristics of the project. These specific characteristics were its mere size (both in spatial and in financial terms), the duration and complexity of the decision-making process, and uncertainty about the effects of the alternatives. Requirements for the method to be used were an integrated analysis of the effects and the taking into account of both the short and the long term effects (over a hundred years) of the alternatives. As a result of these characteristics and requirements, the decision-making process in- volves considerations of intra- and intergenerational equity, the discount factor to be used, transparency of the decision-making process to the public and the possibility to adapt the results of the economic evaluation to changing insights and opinions.

An alternative approach for socio-hydrology: case study research

NASA Astrophysics Data System (ADS)

Mostert, Erik

2018-01-01

Currently the most popular approach in socio hydrology is to develop coupled human-water models. This article proposes an alternative approach, qualitative case study research, involving a systematic review of (1) the human activities affecting the hydrology in the case, (2) the main human actors, and (3) the main factors influencing the actors and their activities. Moreover, this article presents a case study of the Dommel Basin in Belgium and the Netherlands, and compares this with a coupled model of the Kissimmee Basin in Florida. In both basins a pendulum swing from water resources development and control to protection and restoration can be observed. The Dommel case study moreover points to the importance of institutional and financial arrangements, community values, and broader social, economic, and technical developments. These factors are missing from the Kissimmee model. Generally, case studies can result in a more complete understanding of individual cases than coupled models, and if the cases are selected carefully and compared with previous studies, it is possible to generalize on the basis of them. Case studies also offer more levers for management and facilitate interdisciplinary cooperation. Coupled models, on the other hand, can be used to generate possible explanations of past developments and quantitative scenarios for future developments. The article concludes that, given the limited attention they currently get and their potential benefits, case studies deserve more attention in socio-hydrology.

77 FR 51739 - Approval and Promulgation of Implementation Plans; Tennessee; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... original Eastman BART determination and technical analysis provided in the State's April 4, 2008, SIP... EPA cannot read your comment due to technical difficulties and cannot contact you for clarification... the requirements for a BART alternative determination? III. What is EPA's analysis of Tennessee's May...

Technical Information Resource on Rare Earth Elements Now Available to Public and Private Sector Stakeholders

EPA Science Inventory

A new EPA technical information resource, “Rare Earth Elements: A Review of Production, Processing, Recycling, and Associated Environmental Issues” has been produced as an introductory resource for those interested in learning more about REE mining and alternatives to meet demand...

A Bit More to It: Scholarly Communication Forums as Socio-Technical Interaction Networks.

ERIC Educational Resources Information Center

Kling, Rob; McKim, Geoffrey; King, Adam

2003-01-01

Examines the conceptual models that help to understand the development and sustainability of scholarly and professional communication forums on the Internet. An alternative information processing model that considers information technologies as Socio-Technical Interaction Networks (STINs) and a method for modeling electronic forums as STINs are…

Teacher Perceptions of the Indiana Workplace Specialist I Licensure Training Program during the 2011-2012 Academic Year

ERIC Educational Resources Information Center

Lazaros, Edward J.; Cotton, Samuel; Brown, Paul B.

2012-01-01

Alternative teacher licensure, also known as alternative teacher certification, is a growing national trend in education, and it has long been common in the field of career and technical education. Alternatively licensed teachers often enter teaching with a wealth of subject area knowledge due to their previous work experience. Mentorship programs…

Global Spent Fuel Logistics Systems Study (GSFLS). Volume 3A. GSFLS technical analysis (appendix). Interim report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kriger, A.

1978-01-31

This report is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. The technical and financial considerations underlying a global spent fuel logistics systems have been studied and are reported. The Pacific Basin is used as a model throughout this report; however the stated methodology and, in many cases, considerations and conclusions are applicable to other global regions. Spent fuel discharge profiles for Pacific Basin Countries were used to determine the technical systems requirements for alternative concepts. Functional analyses and flows were generated to define both system design requirements and logistics parameters. Amore » technology review was made to ascertain the state-of-the-art of relevant GSFLS technical systems. Modular GSFLS facility designs were developed using the information generated from the functional analysis and technology review. The modular facility designs were used as a basis for siting and cost estimates for various GSFLS alternatives. Various GSFLS concepts were analyzed from a financial and economic perspective in order to provide total concepts costs and ascertain financial and economic sensitivities to key GSFLS variations. Results of the study include quantification of GSFLS facility and hardware requirements; drawings of relevant GSFLS facility designs; system cost estimates; financial reports - including user service charges; and comparative analyses of various GSFLS alternatives.« less

Microsurgical anatomy of the transsylvian translimen insula approach to the mediobasal temporal lobe: Technical considerations and case illustration.

PubMed

Straus, David; Byrne, Richard W; Sani, Sepehr; Serici, Anthony; Moftakhar, Roham

2013-01-01

Various vascular, neoplastic, and epileptogenic pathologies occur in the mediobasal temporal region. A transsylvian translimen insula (TTI) approach can be used as an alternative to temporal transcortical approach to the mediobasal temporal region. The aim of this study was to demonstrate the surgical anatomy of the TTI approach, including the gyral, sulcal, and vascular anatomy in and around the limen insula. The use of this approach is illustrated in the resection of a complex arteriovenous malformation. The TTI approach to the mediobasal temporal region was performed on three silicone-injected cadaveric heads. The gyral, sulcal, and arterial anatomy of the limen insula was studied in six formalin-fixed injected hemispheres. The TTI approach provided access to the anterior and middle segments of the mediobasal temporal lobe region as well as allowing access to temporal horn of the lateral ventricle. Using this approach we were able to successfully resect an arteriovenous malformation of the dominant medial temporal lobe. The TTI approach provides a viable surgical route to the region of mediobasal temporal lobe region. This approach offers an advantage over the temporal transcortical route in that there is less risk of damage to optic radiations and speech area in the dominant hemisphere.

The Technical Communicator as Advocate: Integrating a Social Justice Approach in Technical Communication

ERIC Educational Resources Information Center

Jones, Natasha N.

2016-01-01

This article argues for the need for a social justice approach to technical communication research and pedagogy. Given previous calls by scholars in technical and professional communication (TPC) for an attention to diversity, inclusion, and equality, the author examines the place and purpose of social justice in TPC and provides useful approaches…

Approach to an Affordable and Productive Space Transportation System

NASA Technical Reports Server (NTRS)

McCleskey, Carey M.; Rhodes, Russel E.; Lepsch, Roger A.; Henderson, Edward M.; Robinson, John W.

2012-01-01

This paper describes an approach for creating space transportation architectures that are affordable, productive, and sustainable. The architectural scope includes both flight and ground system elements, and focuses on their compatibility to achieve a technical solution that is operationally productive, and also affordable throughout its life cycle. Previous papers by the authors and other members of the Space Propulsion Synergy Team (SPST) focused on space flight system engineering methods, along with operationally efficient propulsion system concepts and technologies. This paper follows up previous work by using a structured process to derive examples of conceptual architectures that integrate a number of advanced concepts and technologies. The examples are not intended to provide a near-term alternative architecture to displace current near-term design and development activity. Rather, the examples demonstrate an approach that promotes early investments in advanced system concept studies and trades (flight and ground), as well as in advanced technologies with the goal of enabling highly affordable, productive flight and ground space transportation systems.

Proposed reliability cost model

NASA Technical Reports Server (NTRS)

Delionback, L. M.

1973-01-01

The research investigations which were involved in the study include: cost analysis/allocation, reliability and product assurance, forecasting methodology, systems analysis, and model-building. This is a classic example of an interdisciplinary problem, since the model-building requirements include the need for understanding and communication between technical disciplines on one hand, and the financial/accounting skill categories on the other. The systems approach is utilized within this context to establish a clearer and more objective relationship between reliability assurance and the subcategories (or subelements) that provide, or reenforce, the reliability assurance for a system. Subcategories are further subdivided as illustrated by a tree diagram. The reliability assurance elements can be seen to be potential alternative strategies, or approaches, depending on the specific goals/objectives of the trade studies. The scope was limited to the establishment of a proposed reliability cost-model format. The model format/approach is dependent upon the use of a series of subsystem-oriented CER's and sometimes possible CTR's, in devising a suitable cost-effective policy.

Endonasal management of pediatric congenital transsphenoidal encephaloceles: nuances of a modified reconstruction technique. Technical note and report of 3 cases.

PubMed

Zeinalizadeh, Mehdi; Sadrehosseini, Seyed Mousa; Habibi, Zohreh; Nejat, Farideh; Silva, Harley Brito da; Singh, Harminder

2017-03-01

OBJECTIVE Congenital transsphenoidal encephaloceles are rare malformations, and their surgical treatment remains challenging. This paper reports 3 cases of transsphenoidal encephalocele in 8- to 24-month-old infants, who presented mainly with airway obstruction, respiratory distress, and failure to thrive. METHODS The authors discuss the surgical management of these lesions via a minimally invasive endoscopic endonasal approach, as compared with the traditional transcranial and transpalatal approaches. A unique endonasal management algorithm for these lesions is outlined. The lesions were repaired with no resection of the encephalocele sac, and the cranial base defects were reconstructed with titanium mesh plates and vascular nasoseptal flaps. RESULTS Reduction of the encephalocele and reconstruction of the skull base was successfully accomplished in all 3 cases, with favorable results. CONCLUSIONS The described endonasal management algorithm for congenital transsphenoidal encephaloceles is a safe, viable alternative to traditional transcranial and transpalatal approaches, and avoids much of the morbidity associated with these open techniques.

Additively manufactured sub-periosteal jaw implants.

PubMed

Mommaerts, M Y

2017-07-01

Severe bone atrophy jeopardizes the success of endosseous implants. This technical note aims to present the innovative concept of additively manufactured sub-periosteal jaw implants (AMSJIs). Digital datasets of the patient's jaws and wax trial in occlusion are used to segment the bone and dental arches, for the design of a sub-periosteal frame and abutments in the optimal location related to the dental arch and for the design of the suprastructure. The implants and suprastructure are three-dimensionally (3D) printed in titanium alloy. The provisional denture is 3D-printed in polymer. AMSJIs offer an alternative approach for patients with extreme jaw bone atrophy. This report refers to the use of this technique for full maxillary rehabilitation, but partial defects in either jaw and extended post-resection defects may also be approached using the same technique. This customized, prosthesis-driven reverse-engineering approach avoids bone grafting and provides immediate functional restoration with one surgical session. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Medicare Program; Merit-Based Incentive Payment System (MIPS) and Alternative Payment Model (APM) Incentive Under the Physician Fee Schedule, and Criteria for Physician-Focused Payment Models. Final rule with comment period.

PubMed

2016-11-04

The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) repeals the Medicare sustainable growth rate (SGR) methodology for updates to the physician fee schedule (PFS) and replaces it with a new approach to payment called the Quality Payment Program that rewards the delivery of high-quality patient care through two avenues: Advanced Alternative Payment Models (Advanced APMs) and the Merit-based Incentive Payment System (MIPS) for eligible clinicians or groups under the PFS. This final rule with comment period establishes incentives for participation in certain alternative payment models (APMs) and includes the criteria for use by the Physician-Focused Payment Model Technical Advisory Committee (PTAC) in making comments and recommendations on physician-focused payment models (PFPMs). Alternative Payment Models are payment approaches, developed in partnership with the clinician community, that provide added incentives to deliver high-quality and cost-efficient care. APMs can apply to a specific clinical condition, a care episode, or a population. This final rule with comment period also establishes the MIPS, a new program for certain Medicare-enrolled practitioners. MIPS will consolidate components of three existing programs, the Physician Quality Reporting System (PQRS), the Physician Value-based Payment Modifier (VM), and the Medicare Electronic Health Record (EHR) Incentive Program for Eligible Professionals (EPs), and will continue the focus on quality, cost, and use of certified EHR technology (CEHRT) in a cohesive program that avoids redundancies. In this final rule with comment period we have rebranded key terminology based on feedback from stakeholders, with the goal of selecting terms that will be more easily identified and understood by our stakeholders.

Consideration of What May Influence Student Outcomes on Alternate Assessment.

ERIC Educational Resources Information Center

Browder, Diane M.; Fallin, Kathy; Davis, Stephanie; Karvonen, Meagan

2003-01-01

This article describes variables that may influence alternate assessment outcomes for students with disabilities and offers recommendations to enhance student achievement. These variables include technical quality, curriculum access, data collection, instructional effectiveness, risk factors, and resources allocated to instruction. Two of four…

10 CFR 51.103 - Record of decision-general.

Code of Federal Regulations, 2011 CFR

2011-01-01

... were included in the range of alternatives discussed in the environmental impact statement, and specify... preferences among alternatives based on relevant factors, including economic and technical considerations... impacts of license renewal are so great that preserving the option of license renewal for energy planning...

A Robust Alternative to the Normal Distribution.

DTIC Science & Technology

1982-07-07

for any Purpose of the United States Governuent DEPARTMENT OF STATISTICS t -, STANFORD UIVERSITY I STANFORD, CALIFORNIA A Robust Alternative to the...Stanford University Technical Report No. 3. [5] Bhattacharya, S. K. (1966). A Modified Bessel Function lodel in Life Testing. Metrika 10, 133-144

Considerations for rigid vs. flexible pavement designs when allowed as alternate bids : technical report.

DOT National Transportation Integrated Search

2009-08-01

This report documents the research conducted for the Texas Department of Transportation (TxDOT) : concerning the use of pavement alternates. The scope of the project includes reviewing the state-of-thepractice : in methods used for pavement type sele...

Creep-fatigue life prediction for engine hot section materials (isotropic)

NASA Technical Reports Server (NTRS)

Moreno, V.

1982-01-01

The objectives of this program are the investigation of fundamental approaches to high temperature crack initiation life prediction, identification of specific modeling strategies and the development of specific models for component relevant loading conditions. A survey of the hot section material/coating systems used throughout the gas turbine industry is included. Two material/coating systems will be identified for the program. The material/coating system designated as the base system shall be used throughout Tasks 1-12. The alternate material/coating system will be used only in Task 12 for further evaluation of the models developed on the base material. In Task II, candidate life prediction approaches will be screened based on a set of criteria that includes experience of the approaches within the literature, correlation with isothermal data generated on the base material, and judgements relative to the applicability of the approach for the complex cycles to be considered in the option program. The two most promising approaches will be identified. Task 3 further evaluates the best approach using additional base material fatigue testing including verification tests. Task 4 consists of technical, schedular, financial and all other reporting requirements in accordance with the Reports of Work clause.

A Day in the Life of an Industrial Hearing Conservationist: A Template for Successful Career Education and Outreach Presentations

NASA Technical Reports Server (NTRS)

Cooper, Beth A.

1997-01-01

Whether in a classroom setting or at a local community meeting, opportunities for providing descriptive and positive information about our professions to an audience unfamiliar with acoustics, noise control or hearing conservation often call for alternatives to technical demonstrations that illustrate principles of acoustics or noise control. More importantly, successful outreach presentations must convey images of our day-to-day activities and the challenges we address, many of which are non-technical. One successful approach to career outreach presentations makes use of a collection of photo slides featuring the speaker, his colleagues, customers and workplaces to vividly illustrate the specific job tasks, people and environment of the speaker's job or career. Against this fluid and multi-dimensional visual backdrop, an accompanying script addresses the main theme. A comprehensive photo slide collection may be established gradually, often by making use of and adding to technical and personal slides already in the speaker's possession. Slide collections are portable, easily and quickly reconfigured for back-to-back or spontaneous engagements, and they are well suited to speaking opportunities where technical presentations or demonstrations are not practical or appropriate. A carefully chosen sequence of photo slides minimizes the need for speaker's notes, as each photo itself provides a visual prompt. Although photo slide presentations are appropriate to a variety of outreach and professional settings, the specific illustrative and explanatory material presented here illustrates their application in career education outreach activities, using industrial hearing conservation as an example.

Meta-analysis of the technical performance of an imaging procedure: guidelines and statistical methodology.

PubMed

Huang, Erich P; Wang, Xiao-Feng; Choudhury, Kingshuk Roy; McShane, Lisa M; Gönen, Mithat; Ye, Jingjing; Buckler, Andrew J; Kinahan, Paul E; Reeves, Anthony P; Jackson, Edward F; Guimaraes, Alexander R; Zahlmann, Gudrun

2015-02-01

Medical imaging serves many roles in patient care and the drug approval process, including assessing treatment response and guiding treatment decisions. These roles often involve a quantitative imaging biomarker, an objectively measured characteristic of the underlying anatomic structure or biochemical process derived from medical images. Before a quantitative imaging biomarker is accepted for use in such roles, the imaging procedure to acquire it must undergo evaluation of its technical performance, which entails assessment of performance metrics such as repeatability and reproducibility of the quantitative imaging biomarker. Ideally, this evaluation will involve quantitative summaries of results from multiple studies to overcome limitations due to the typically small sample sizes of technical performance studies and/or to include a broader range of clinical settings and patient populations. This paper is a review of meta-analysis procedures for such an evaluation, including identification of suitable studies, statistical methodology to evaluate and summarize the performance metrics, and complete and transparent reporting of the results. This review addresses challenges typical of meta-analyses of technical performance, particularly small study sizes, which often causes violations of assumptions underlying standard meta-analysis techniques. Alternative approaches to address these difficulties are also presented; simulation studies indicate that they outperform standard techniques when some studies are small. The meta-analysis procedures presented are also applied to actual [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) test-retest repeatability data for illustrative purposes. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Meta-analysis of the technical performance of an imaging procedure: Guidelines and statistical methodology

PubMed Central

Huang, Erich P; Wang, Xiao-Feng; Choudhury, Kingshuk Roy; McShane, Lisa M; Gönen, Mithat; Ye, Jingjing; Buckler, Andrew J; Kinahan, Paul E; Reeves, Anthony P; Jackson, Edward F; Guimaraes, Alexander R; Zahlmann, Gudrun

2017-01-01

Medical imaging serves many roles in patient care and the drug approval process, including assessing treatment response and guiding treatment decisions. These roles often involve a quantitative imaging biomarker, an objectively measured characteristic of the underlying anatomic structure or biochemical process derived from medical images. Before a quantitative imaging biomarker is accepted for use in such roles, the imaging procedure to acquire it must undergo evaluation of its technical performance, which entails assessment of performance metrics such as repeatability and reproducibility of the quantitative imaging biomarker. Ideally, this evaluation will involve quantitative summaries of results from multiple studies to overcome limitations due to the typically small sample sizes of technical performance studies and/or to include a broader range of clinical settings and patient populations. This paper is a review of meta-analysis procedures for such an evaluation, including identification of suitable studies, statistical methodology to evaluate and summarize the performance metrics, and complete and transparent reporting of the results. This review addresses challenges typical of meta-analyses of technical performance, particularly small study sizes, which often causes violations of assumptions underlying standard meta-analysis techniques. Alternative approaches to address these difficulties are also presented; simulation studies indicate that they outperform standard techniques when some studies are small. The meta-analysis procedures presented are also applied to actual [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) test–retest repeatability data for illustrative purposes. PMID:24872353

Experimental Null Method to Guide the Development of Technical Procedures and to Control False-Positive Discovery in Quantitative Proteomics.

PubMed

Shen, Xiaomeng; Hu, Qiang; Li, Jun; Wang, Jianmin; Qu, Jun

2015-10-02

Comprehensive and accurate evaluation of data quality and false-positive biomarker discovery is critical to direct the method development/optimization for quantitative proteomics, which nonetheless remains challenging largely due to the high complexity and unique features of proteomic data. Here we describe an experimental null (EN) method to address this need. Because the method experimentally measures the null distribution (either technical or biological replicates) using the same proteomic samples, the same procedures and the same batch as the case-vs-contol experiment, it correctly reflects the collective effects of technical variability (e.g., variation/bias in sample preparation, LC-MS analysis, and data processing) and project-specific features (e.g., characteristics of the proteome and biological variation) on the performances of quantitative analysis. To show a proof of concept, we employed the EN method to assess the quantitative accuracy and precision and the ability to quantify subtle ratio changes between groups using different experimental and data-processing approaches and in various cellular and tissue proteomes. It was found that choices of quantitative features, sample size, experimental design, data-processing strategies, and quality of chromatographic separation can profoundly affect quantitative precision and accuracy of label-free quantification. The EN method was also demonstrated as a practical tool to determine the optimal experimental parameters and rational ratio cutoff for reliable protein quantification in specific proteomic experiments, for example, to identify the necessary number of technical/biological replicates per group that affords sufficient power for discovery. Furthermore, we assessed the ability of EN method to estimate levels of false-positives in the discovery of altered proteins, using two concocted sample sets mimicking proteomic profiling using technical and biological replicates, respectively, where the true-positives/negatives are known and span a wide concentration range. It was observed that the EN method correctly reflects the null distribution in a proteomic system and accurately measures false altered proteins discovery rate (FADR). In summary, the EN method provides a straightforward, practical, and accurate alternative to statistics-based approaches for the development and evaluation of proteomic experiments and can be universally adapted to various types of quantitative techniques.

Guidance, Navigation and Control (GN and C) Design Overview and Flight Test Results from NASA's Max Launch Abort System (MLAS)

NASA Technical Reports Server (NTRS)

Dennehy, Cornelius J.; Lanzi, Raymond J.; Ward, Philip R.

2010-01-01

The National Aeronautics and Space Administration Engineering and Safety Center designed, developed and flew the alternative Max Launch Abort System (MLAS) as risk mitigation for the baseline Orion spacecraft launch abort system already in development. The NESC was tasked with both formulating a conceptual objective system design of this alternative MLAS as well as demonstrating this concept with a simulated pad abort flight test. Less than 2 years after Project start the MLAS simulated pad abort flight test was successfully conducted from Wallops Island on July 8, 2009. The entire flight test duration was 88 seconds during which time multiple staging events were performed and nine separate critically timed parachute deployments occurred as scheduled. This paper provides an overview of the guidance navigation and control technical approaches employed on this rapid prototyping activity; describes the methodology used to design the MLAS flight test vehicle; and lessons that were learned during this rapid prototyping project are also summarized.

A novel combination of two minimally invasive surgical techniques in the management of refractory radiation necrosis: Technical note.

PubMed

Habboub, Ghaith; Sharma, Mayur; Barnett, Gene H; Mohammadi, Alireza M

2017-01-01

Minimally-invasive approaches are attractive alternative to standard craniotomy for large intracranial tumors with potentially lesser morbidity. In this report, we describe a sequential combination of two minimally-invasive surgical techniques to treat a large intracranial tumor. A 49year-old woman presented with a history of breast cancer and large left parietal metastasis with significant perilesional edema. This was initially managed by whole brain radiation therapy and stereotactic radiosurgery. The patient underwent laser ablation of the tumor followed by internal tumor debulking using an exoscopic-assisted tubular retractor system. Post-operative MRI showed gross total coverage of the tumor by laser ablation and alleviation of mass effect. The patient recovered well and discharged on second postoperative day. The minimally-invasive combination of laser ablation followed by internal debulking using a tubular retractor device could be done safely and effectively as a minimally invasive alternative to standard craniotomy for large intracranial tumors. Copyright © 2016 Elsevier Ltd. All rights reserved.

An integrated approach for the management of demolition waste in Cyprus.

PubMed

Kourmpanis, Basilis; Papadopoulos, Achilleas; Moustakas, Konstantinos; Kourmoussis, Fotis; Stylianou, Marinos; Loizidou, Maria

2008-12-01

This study investigated the generation and management of demolition waste (DW) in Cyprus. A methodology has been developed and applied for the estimation of the quantities of the waste stream under examination, since quantitative primary data were not available. The existing situation relating to the practices applied for the management of DW was investigated and assessed. Furthermore, a multi-criteria analysis method (PROMETHEE II) was developed and applied in order to examine alternative systems that could be implemented for the management of the DW in the country. In particular, nine management systems (scenarios) were examined, evaluated and ranked according to their efficiency using seventeen individual criteria, divided into four groups (social-legislative, environmental, economic and technical). The ranking of the alternative waste management scenarios indicated that the optimum management system for possible implementation in the island included complete selective demolition procedures and transfer of mixed recyclable materials to the recycling centre and non-recyclable material to landfill.

Retroperitoneoscopic adrenalectomy in pheochromocytoma

PubMed Central

Hisano, Marcelo; Vicentini, Fabio Carvalho; Srougi, Miguel

2012-01-01

Since the first laparoscopic adrenalectomy, the technique has evolved and it has become the standard of care for many adrenal diseases, including pheochromocytoma. Two laparoscopic accesses to the adrenal have been developed: transperitoneal and retroperitoneal. Retroperitoneoscopic adrenalectomy may be recommended for the treatment of pheochromocytoma with the same peri-operative outcomes of the transperitoneal approach because it allows direct access to the adrenal glands without increasing the operative risks. Although technically more demanding than the transperitoneal approach, retroperitoneoscopy can shorten the mean operative time, which is critical for cases with pheochromocytoma where minimizing the potential for intra-operative hemodynamic changes is essential. Blood loss and the convalescence time can be also shortened by this approach. There is no absolute indication for either the transperitoneal or retroperitoneal approach; however, the latter procedure may be the best option for patients who have undergone previous abdominal surgery and obese patients. Also, retroperitoneoscopic adrenalectomy is a good alternative for treating cases with inherited pheochromocytomas, such as multiple endocrine neoplasia type 2A, in which the pheochromocytoma is highly prevalent and frequently occurs bilaterally. PMID:22584723

Promising roadmap alternatives for the SpaceLiner

NASA Astrophysics Data System (ADS)

Sippel, Martin

2010-06-01

The paper describes the vision and potential roadmap alternatives of an ultrafast intercontinental passenger transport based on a rocket powered two-stage reusable vehicle. An operational scenario and the latest technical lay-out of the configuration's preliminary design including flight performance are described. The question of how the revolutionary ultrafast transport can be realized is addressed by an assessment of the different technological and programmatic roadmap alternatives.

United States Air Force Training Line Simulator. Final Report.

ERIC Educational Resources Information Center

Nauta, Franz; Pierce, Michael B.

This report describes the technical aspects and potential applications of a computer-based model simulating the flow of airmen through basic training and entry-level technical training. The objective of the simulation is to assess the impacts of alternative recruit classification and training policies under a wide variety of assumptions regarding…

Cost Finding Principles and Procedures. Preliminary Field Review Edition. Technical Report 26.

ERIC Educational Resources Information Center

Ziemer, Gordon; And Others

This report is part of the Larger Cost Finding Principles Project designed to develop a uniform set of standards, definitions, and alternative procedures that will use accounting and statistical data to find the full cost of resources utilized in the process of producing institutional outputs. This technical report describes preliminary procedures…

77 FR 1129 - Revisions to Test Methods and Testing Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-09

...This action proposes editorial and technical corrections necessary for source testing of emissions and operations. The revisions include the addition of alternative equipment and methods as well as corrections to technical and typographical errors. We also solicit public comment on potential changes to the current procedures for determining emission stratification.

Economic Evaluation of Building Design, Construction, Operation and Maintenance. Instructor's Manual.

ERIC Educational Resources Information Center

Ruegg, Rosalie T.; Marshall, Harold E.

This instructor's manual describes each section of a 3-day technical seminar on how to measure the economic impact of alternative designs, systems, and operation and maintenance strategies in federal buildings. The manual was prepared to help instructors of the General Services Administration conduct technically sound and comprehensive seminars.…

A Feminist Perspective on Technical Communicative Action: Exploring How Alternative Worldviews Affect Environmental Remediation Efforts.

ERIC Educational Resources Information Center

Ross, Susan Mallon

1994-01-01

Describes the current practices in public environmental debate and reform movements as relevant to technical communicators. Reviews a case in which the Mohawk community clashed with the Environmental Protection Agency. Explores the clash of worldviews and shows how a feminist perspective might aid in such a conflict. (HB)

Strategic Technology Investment Analysis: An Integrated System Approach

NASA Technical Reports Server (NTRS)

Adumitroaie, V.; Weisbin, C. R.

2010-01-01

Complex technology investment decisions within NASA are increasingly difficult to make such that the end results are satisfying the technical objectives and all the organizational constraints. Due to a restricted science budget environment and numerous required technology developments, the investment decisions need to take into account not only the functional impact on the program goals, but also development uncertainties and cost variations along with maintaining a healthy workforce. This paper describes an approach for optimizing and qualifying technology investment portfolios from the perspective of an integrated system model. The methodology encompasses multi-attribute decision theory elements and sensitivity analysis. The evaluation of the degree of robustness of the recommended portfolio provides the decision-maker with an array of viable selection alternatives, which take into account input uncertainties and possibly satisfy nontechnical constraints. The methodology is presented in the context of assessing capability development portfolios for NASA technology programs.

Principal Components Analysis of a JWST NIRSpec Detector Subsystem

NASA Technical Reports Server (NTRS)

Arendt, Richard G.; Fixsen, D. J.; Greenhouse, Matthew A.; Lander, Matthew; Lindler, Don; Loose, Markus; Moseley, S. H.; Mott, D. Brent; Rauscher, Bernard J.; Wen, Yiting;

Motivating students' participation in a computer networks course by means of magic, drama and games.

PubMed

Hilas, Constantinos S; Politis, Anastasios

2014-01-01

The recent economic crisis has forced many universities to cut down expenses by packing students into large lecture groups. The problem with large auditoria is that they discourage dialogue between students and faculty and they burden participation. Adding to this, students in computer science courses usually find the field to be full of theoretical and technical concepts. Lack of understanding leads them to lose interest and / or motivation. Classroom experience shows that the lecturer could employ alternative teaching methods, especially for early-year undergraduate students, in order to grasp their interest and introduce basic concepts. This paper describes some of the approaches that may be used to keep students interested and make them feel comfortable as they comprehend basic concepts in computer networks. The lecturing procedure was enriched with games, magic tricks and dramatic representations. This approach was used experimentally for two semesters and the results were more than encouraging.

Technical tips for peroral transluminal cholangioscopy using novel single-operator cholangioscope (with videos).

PubMed

Ogura, Takeshi; Takagi, Wataru; Kurisu, Yoshitaka; Higuchi, Kazuhide

2016-10-01

Endoscopic retrograde cholangiopancreatography (ERCP) is the gold-standard modality for diagnosis and therapy of bilio-pancreatic disease. In particular, peroral cholangiography (POCS) is a useful modality not only for diagnosing biliary disease, but also for therapeutic procedures such as electrohydraulic lithotripsy. The SPY-DS single-operator cholangioscope has recently become available, and offers favorable visualization, a wide view, suction function and a larger accessory working channel. However, if the duodenoscope cannot be advanced into the ampulla of Vater for reasons such as surgical anatomy, POCS cannot be performed. On the other hand, percutaneous transhepatic cholangiodrainage (PTCD) has been developed as an alternative endoscopic ultrasound-guided approach to the biliary tract. Peroral transluminal cholangioscopy (PTLC) using SPY-DS is a novel approach. Because transluminal interventional procedures under endoscopic ultrasound guidance have recently been developed, our technique may have clinical impact for selected cases. © 2016 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

Cell and small animal models for phenotypic drug discovery.

PubMed

Szabo, Mihaly; Svensson Akusjärvi, Sara; Saxena, Ankur; Liu, Jianping; Chandrasekar, Gayathri; Kitambi, Satish S

2017-01-01

The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative platform for drug discovery. This review provides an overview of the various model systems and technical advances in imaging and image analyses that strengthen the PDD platform. In PDD screens, compounds of therapeutic value are identified based on the phenotypic perturbations produced irrespective of target(s) or mechanism of action. In this article, examples of phenotypic changes that can be detected and quantified with relative ease in a cell-based setup are discussed. In addition, a higher order of PDD screening setup using small animal models is also explored. As PDD screens integrate physiology and multiple signaling mechanisms during the screening process, the identified hits have higher biomedical applicability. Taken together, this review highlights the advantages gained by adopting a PDD approach in drug discovery. Such a PDD platform can complement target-based systems that are currently in practice to accelerate drug discovery.

Non-surgical biliary drainage - technique, indications and results.

PubMed

Riemann, J F; Lux, G; Rösch, W; Beickert-Sterba, A

1981-07-01

Nonsurgical biliary drainage offers a therapeutic alternative in the palliation of malignant obstructive jaundice. Two basic approaches are available. The percutaneous transhepatic method can be employed either for external drainage or for the placement of an internal endoprosthesis. In the case of the transduodenal, transpapillary approach, either a pigtail catheter can be placed, after prior papillotomy, or - with or without the need to split the papillar - a nasobiliary drainage tube can be introduced. Successful drainage was achieved in 67 patients. In the majority of cases, external drainage was performed as a palliative measure in inoperable carcinoma of the biliodigestive system. In addition, however, pre-operative temporary drainage was also carried out to reduce the risks of surgery in patients with severe obstructive jaundice. The complication rate was low. Apart from biliary peritonitis, cholangitis and minor bleeds were observed. The rate of failure for technical reasons was a relatively low 10%.

Open C2 Vertebroplasty: Case Report, Technique, and Review of Literature

PubMed Central

Shetty, Sathwik Raviraj; Ganigi, Praveen Mahadev; Mandanna, Bopanna Kanjithanda

2017-01-01

Osteolytic lesions of C2 are challenging pathologies to manage. Vertebroplasty, a minimally invasive technique has been widely used in lytic lesions of thoracic and lumbar spine. However, there has been limited experience with percutaneous vertebroplasty at C2, and the procedure is technically difficult. We describe a safer alternative technique of open vertebroplasty for lytic lesions involving the axis. Methods: The procedure was performed in a 49-year-old male with a metastatic lytic lesion involving the body and dens of C2 using an anterior cervical approach. The patient had an immediate reduction in pain with complete pain relief at 2 weeks and good stability at 3-month follow-up. The patient did not have any perioperative or postoperative complications. The anterior cervical approach open C2 vertebroplasty is a safe and effective option in the management of C2 osteolytic lesions. PMID:29114290

Surpassing the current limitations of biohydrogen production systems: The case for a novel hybrid approach.

PubMed

Boboescu, Iulian Zoltan; Gherman, Vasile Daniel; Lakatos, Gergely; Pap, Bernadett; Bíró, Tibor; Maróti, Gergely

2016-03-01

The steadily increase of global energy requirements has brought about a general agreement on the need for novel renewable and environmentally friendly energy sources and carriers. Among the alternatives to a fossil fuel-based economy, hydrogen gas is considered a game-changer. Certain methods of hydrogen production can utilize various low-priced industrial and agricultural wastes as substrate, thus coupling organic waste treatment with renewable energy generation. Among these approaches, different biological strategies have been investigated and successfully implemented in laboratory-scale systems. Although promising, several key aspects need further investigation in order to push these technologies towards large-scale industrial implementation. Some of the major scientific and technical bottlenecks will be discussed, along with possible solutions, including a thorough exploration of novel research combining microbial dark fermentation and algal photoheterotrophic degradation systems, integrated with wastewater treatment and metabolic by-products usage. Copyright © 2016 Elsevier Ltd. All rights reserved.

The etiology of low back pain in military helicopter aviators: prevention and treatment.

PubMed

Pelham, Thomas W; White, Harold; Holt, Laurence E; Lee, S Wayne

2005-01-01

Low back pain (LPB) is a major health problem among military rotary-wing aircrews worldwide. In order to define the etiology and propose remedies to LBP in helicopter aviators a review and critique of the literature was conducted. In-flight sitting posture and vibration generated by the aircraft were identified as high risk factors for LBP. Consequently, researchers recommended ergonomic modifications to the crew stations. The efficacy of these technical interventions has not been proven. As well, these design changes are not financially practical. Following an in depth kinesiological analysis of the physical demands of this type of flying, and preliminary experimentation, an alternative aeromedical approach focusing on the aircrew rather than the craft is presented. The authors propose a set of flight-specific exercises that might effectively deal with this problem. A thorough testing of this approach is envisioned.

Alternatives for jet engine control

NASA Technical Reports Server (NTRS)

Sain, M. K.

1984-01-01

The technical progress of researches on alternatives for jet engine control is reported. Extensive numerical testing is included. It is indicated that optimal inputs contribute significantly to the process of calculating tensor approximations for nonlinear systems, and that the resulting approximations may be order-reduced in a systematic way.

Alternative Fuels Data Center: Project Assistance

Science.gov Websites

emerging transportation technologies. For examples of successful projects, explore alternative transportation case studies. Find My Local Coalition ZIP Code or City and State Search Map of the United States stakeholders network to learn from one another's experiences and identify potential project partners. Technical

Present and Probable CATV/Broadband-Communication Technology.

ERIC Educational Resources Information Center

Ward, John E.

The study reports on technical and cost factors affecting future growth of Cable TV (CATV) systems and the development of the "wired nation." Comparisons are made between alternatives for distributing CATV signals and alternative prototypes for subscriber home terminals. Multi-cable, augmented-channel (with converter), and switched CATV…

Technical notes and correspondence: Stochastic robustness of linear time-invariant control systems

NASA Technical Reports Server (NTRS)

Stengel, Robert F.; Ray, Laura R.

1991-01-01

A simple numerical procedure for estimating the stochastic robustness of a linear time-invariant system is described. Monte Carlo evaluations of the system's eigenvalues allows the probability of instability and the related stochastic root locus to be estimated. This analysis approach treats not only Gaussian parameter uncertainties but non-Gaussian cases, including uncertain-but-bounded variation. Confidence intervals for the scalar probability of instability address computational issues inherent in Monte Carlo simulation. Trivial extensions of the procedure admit consideration of alternate discriminants; thus, the probabilities that stipulated degrees of instability will be exceeded or that closed-loop roots will leave desirable regions can also be estimated. Results are particularly amenable to graphical presentation.

Hanford Site Composite Analysis Technical Approach Description: Automated Quality Assurance Process Design.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dockter, Randy E.

2017-07-31

The U.S. Department of Energy (DOE) in DOE O 435.1 Chg. 1, Radioactive Waste Management, requires the preparation and maintenance of a composite analysis (CA). The primary purpose of the CA is to provide a reasonable expectation that the primary public dose limit is not likely to be exceeded by multiple source terms that may significantly interact with plumes originating at a low-level waste disposal facility. The CA is used to facilitate planning and land use decisions that help assure disposal facility authorization will not result in long-term compliance problems; or, to determine management alternatives, corrective actions, or assessment needsmore » if potential problems are identified.« less

Hanford Site Composite Analysis Technical Approach Description: Atmospheric Transport Modeling.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, B.; Lehman, L. L.

2017-10-02

The U.S. Department of Energy (DOE) in DOE O 435.1 Chg. 1, Radioactive Waste Management, requires the preparation and maintenance of a composite analysis (CA). The primary purpose of the CA is to provide a reasonable expectation that the primary public dose limit is not likely to be exceeded by multiple source terms that may significantly interact with plumes originating at a low-level waste disposal facility. The CA is used to facilitate planning and land use decisions that help assure disposal facility authorization will not result in long-term compliance problems; or, to determine management alternatives, corrective actions or assessment needs,more » if potential problems are identified.« less

Hanford Site Composite Analysis Technical Approach Description: Waste Form Release.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardie, S.; Paris, B.; Apted, M.

2017-09-14

The U.S. Department of Energy (DOE) in DOE O 435.1 Chg. 1, Radioactive Waste Management, requires the preparation and maintenance of a composite analysis (CA). The primary purpose of the CA is to provide a reasonable expectation that the primary public dose limit is not likely to be exceeded by multiple source terms that may significantly interact with plumes originating at a low-level waste disposal facility. The CA is used to facilitate planning and land use decisions that help assure disposal facility authorization will not result in long-term compliance problems; or, to determine management alternatives, corrective actions or assessment needs,more » if potential problems are identified.« less

Hanford Site Composite Analysis Technical Approach Description: Integrated Computational Framework.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, K. J.

2017-09-14

The U.S. Department of Energy (DOE) in DOE O 435.1 Chg. 1, Radioactive Waste Management, requires the preparation and maintenance of a composite analysis (CA). The primary purpose of the CA is to provide a reasonable expectation that the primary public dose limit is not likely to be exceeded by multiple source terms that may significantly interact with plumes originating at a low-level waste disposal facility. The CA is used to facilitate planning and land use decisions that help assure disposal facility authorization will not result in long-term compliance problems; or, to determine management alternatives, corrective actions, or assessment needsmore » if potential problems are identified.« less

Energy efficiency of high-rise buildings

NASA Astrophysics Data System (ADS)

Zhigulina, Anna Yu.; Ponomarenko, Alla M.

2018-03-01

The article is devoted to analysis of tendencies and advanced technologies in the field of energy supply and energy efficiency of tall buildings, to the history of the emergence of the concept of "efficiency" and its current interpretation. Also the article show the difference of evaluation criteria of the leading rating systems LEED and BREEAM. Authors reviewed the latest technologies applied in the construction of energy efficient buildings. Methodological approach to the design of tall buildings taking into account energy efficiency needs to include the primary energy saving; to seek the possibility of production and accumulation of alternative electric energy by converting energy from the sun and wind with the help of special technical devices; the application of regenerative technologies.

Cogeneration technology alternatives study. Volume 6: Computer data

NASA Technical Reports Server (NTRS)

1980-01-01

The potential technical capabilities of energy conversion systems in the 1985 - 2000 time period were defined with emphasis on systems using coal, coal-derived fuels or alternate fuels. Industrial process data developed for the large energy consuming industries serve as a framework for the cogeneration applications. Ground rules for the study were established and other necessary equipment (balance-of-plant) was defined. This combination of technical information, energy conversion system data ground rules, industrial process information and balance-of-plant characteristics was analyzed to evaluate energy consumption, capital and operating costs and emissions. Data in the form of computer printouts developed for 3000 energy conversion system-industrial process combinations are presented.

Technical Criteria and Procedures for Evaluating the Crashworthiness and Occupant Protection Performance of Alternatively Designed Passenger Rail Equipment for Use in Tier I Service

DOT National Transportation Integrated Search

2011-10-01

Criteria and procedures have been developed for assessing crashworthiness and occupant protection performance of alternatively designed trainsets to be used in Tier I (not exceeding 125 mph) passenger service. These criteria and procedures take advan...

Alternatives for jet engine control

NASA Technical Reports Server (NTRS)

Sain, M. K.

1984-01-01

The technical progress of researches Alternatives for Jet Engine Control is reported. A numerical study employing feedback tensors for optimal control of nonlinear systems was completed. It is believed that these studies are the first of their kind. State regulation, with a decrease in control power is demonstrated. A detailed treatment follows.

An improved method of electrode placement in configuration Lead II for the reliable ECG recording by telemetry in the conscious rat.

PubMed

Tontodonati, Marcello; Fasdelli, Nicola; Dorigatti, Roberto

2011-01-01

Telemetry represents the gold standard technique for the acquisition of animal haemodynamic signals in the pharmaceutical preclinical development of new chemical entities. In terms of electrocardiographic signal recording, the quality is well established in large animals, mainly dog, non human primates and minipig, whereas it is still lacking in terms of satisfactory results in rodents (mouse and rat in particular). In very recent times, an increasing interest in early safety prediction for the reduction of cardiovascular attrition has been raised in all the major pharmaceutical companies, focusing in particular, on in vivo models. Crl:CD(SD) and Wistar Han rats (Crl:WI[Han], Charles River) underwent surgery for the implantation of telemetry devices (Data Science International, USA) for the acquisition of blood pressure and electrocardiogram (ECG). A group of male CD rats (N=6) was implanted using the standard procedure as described by DSI technical documentation; another male CD group (N=3) was implanted using the technique described by Sgoifo et al. (1996); a third group (total of N=46, N=26 male CD rats, and N=10 male WI and N=10 female WI) was implanted using an alternative approach developed in our laboratory. The new surgical procedure was analysed based on technical difficulties, time to complete the surgery, time to recover, animal care, survival time after surgery and quality of telemetry signal recordings. Although a quantitative and qualitative comparison with other techniques described in literature was beyond the scope of the present work, based on our laboratory experience, Sgoifo's methodology showed better results compared to DSI standard approach, but surgical procedure was not easy to perform and more invasive. The novel approach described in the present paper was characterised by simplicity, repeatability, high rate of survival and improved quality of ECG signals for all the implanted rats. Telemetry in small rodents became of particular interest in the early safety assessment of cardiovascular liability during the development of new chemical entities. Although several surgical procedures are well described in literature, none seem to offer high standard electrocardiography signals in order to reliably detect intervals or arrhythmias. In the Safety Pharmacology Laboratory at GlaxoSmithKline, Verona (Italy), a novel and alternative surgical placement of the electrocardiographic electrodes in Lead II configuration was developed, in the rat. The scope of the present paper is to illustrate that this alternative surgical procedure is easily reproducible, minimally invasive and gives high standard quality ECG signals. Copyright © 2010 Elsevier Inc. All rights reserved.

Virtual simulation as a learning method in interventional radiology.

PubMed

Avramov, Predrag; Avramov, Milena; Juković, Mirela; Kadić, Vuk; Till, Viktor

2013-01-01

Radiology is the fastest growing discipline of medicine thanks to the implementation of new technologies and very rapid development of imaging diagnostic procedures in the last few decades. On the other hand, the development of imaging diagnostic procedures has put aside the traditional gaining of experience by working on real patients, and the need for other alternatives of learning interventional radiology procedures has emerged. A new method of virtual approach was added as an excellent alternative to the currently known methods of training on physical models and animals. Virtual reality represents a computer-generated reconstruction of anatomical environment with tactile interactions and it enables operators not only to learn on their own mistakes without compromising the patient's safety, but also to enhance their knowledge and experience. It is true that studies published so far on the validity of endovascular simulators have shown certain improvement of operator's technical skills and reduction in time needed for the procedure, but on the other hand, it is still a question whether these skills are transferable to the real patients in the angio room. With further improvement of technology, shortcomings of virtual approach to interventional procedures learning will be less significant and this procedure is likely to become the only method of learning in the near future.

Stakeholder engagement in scenario development process - bioenergy production and biodiversity conservation in eastern Finland.

PubMed

Haatanen, Anniina; den Herder, Michael; Leskinen, Pekka; Lindner, Marcus; Kurttila, Mikko; Salminen, Olli

2014-03-15

In this study participatory approaches were used to develop alternative forest resource management scenarios with particular respect to the effects on increased use of forest bioenergy and its effect on biodiversity in Eastern Finland. As technical planning tools, we utilized a forest management planning system (MELA) and the Tool for Sustainability Impact Assessment (ToSIA) to visualize the impacts of the scenarios. We organized a stakeholder workshop where group discussions were used as a participatory method to get the stakeholder preferences and insights concerning forest resource use in the year 2030. Feedback from the workshop was then complemented with a questionnaire. Based on the results of the workshop and a questionnaire we developed three alternative forest resource scenarios: (1) bioenergy 2030 - in which energy production is more centralized and efficient; (2) biodiversity 2030 - in which harvesting methods are more nature friendly and protected forests make up 10% of the total forest area; and (3) mixed bioenergy + biodiversity 2030 scenario - in which wood production, recreation and nature protection are assigned to the most suitable areas. The study showed that stakeholder engagement combined with the MELA and ToSIA tools can be a useful approach in scenario development. Copyright © 2014 Elsevier Ltd. All rights reserved.

Pros, Cons, and Alternatives to Weight Based Cost Estimating

NASA Technical Reports Server (NTRS)

Joyner, Claude R.; Lauriem, Jonathan R.; Levack, Daniel H.; Zapata, Edgar

2011-01-01

Many cost estimating tools use weight as a major parameter in projecting the cost. This is often combined with modifying factors such as complexity, technical maturity of design, environment of operation, etc. to increase the fidelity of the estimate. For a set of conceptual designs, all meeting the same requirements, increased weight can be a major driver in increased cost. However, once a design is fixed, increased weight generally decreases cost, while decreased weight generally increases cost - and the relationship is not linear. Alternative approaches to estimating cost without using weight (except perhaps for materials costs) have been attempted to try to produce a tool usable throughout the design process - from concept studies through development. This paper will address the pros and cons of using weight based models for cost estimating, using liquid rocket engines as the example. It will then examine approaches that minimize the impct of weight based cost estimating. The Rocket Engine- Cost Model (RECM) is an attribute based model developed internally by Pratt & Whitney Rocketdyne for NASA. RECM will be presented primarily to show a successful method to use design and programmatic parameters instead of weight to estimate both design and development costs and production costs. An operations model developed by KSC, the Launch and Landing Effects Ground Operations model (LLEGO), will also be discussed.

easyCBM Beginning Reading Measures: Grades K-1 Alternate Form Reliability and Criterion Validity with the SAT-10. Technical Report #1403

ERIC Educational Resources Information Center

Wray, Kraig; Lai, Cheng-Fei; Sáez, Leilani; Alonzo, Julie; Tindal, Gerald

2013-01-01

We report the results of an alternate form reliability and criterion validity study of kindergarten and grade 1 (N = 84-199) reading measures from the easyCBM© assessment system and Stanford Early School Achievement Test/Stanford Achievement Test, 10th edition (SESAT/SAT-­10) across 5 time points. The alternate form reliabilities ranged from…

A Robust Scalable Transportation System Concept

NASA Technical Reports Server (NTRS)

Hahn, Andrew; DeLaurentis, Daniel

2006-01-01

This report documents the 2005 Revolutionary System Concept for Aeronautics (RSCA) study entitled "A Robust, Scalable Transportation System Concept". The objective of the study was to generate, at a high-level of abstraction, characteristics of a new concept for the National Airspace System, or the new NAS, under which transportation goals such as increased throughput, delay reduction, and improved robustness could be realized. Since such an objective can be overwhelmingly complex if pursued at the lowest levels of detail, instead a System-of-Systems (SoS) approach was adopted to model alternative air transportation architectures at a high level. The SoS approach allows the consideration of not only the technical aspects of the NAS", but also incorporates policy, socio-economic, and alternative transportation system considerations into one architecture. While the representations of the individual systems are basic, the higher level approach allows for ways to optimize the SoS at the network level, determining the best topology (i.e. configuration of nodes and links). The final product (concept) is a set of rules of behavior and network structure that not only satisfies national transportation goals, but represents the high impact rules that accomplish those goals by getting the agents to "do the right thing" naturally. The novel combination of Agent Based Modeling and Network Theory provides the core analysis methodology in the System-of-Systems approach. Our method of approach is non-deterministic which means, fundamentally, it asks and answers different questions than deterministic models. The nondeterministic method is necessary primarily due to our marriage of human systems with technological ones in a partially unknown set of future worlds. Our goal is to understand and simulate how the SoS, human and technological components combined, evolve.

Fully Transradial Versus Transfemoral Approach for Percutaneous Intervention of Coronary Chronic Total Occlusions Applying the Hybrid Algorithm: Insights From RECHARGE Registry.

PubMed

Bakker, Erik Jan; Maeremans, Joren; Zivelonghi, Carlo; Faurie, Benjamin; Avran, Alexandre; Walsh, Simon; Spratt, James C; Knaapen, Paul; Hanratty, Colm G; Bressollette, Erwan; Kayaert, Peter; Bagnall, Alan J; Egred, Mohaned; Smith, David; McEntegart, Margaret B; Smith, William H T; Kelly, Paul; Irving, John; Smith, Elliot J; Strange, Julian W; Dens, Joseph; Agostoni, Pierfrancesco

2017-09-01

Small observational studies demonstrate the feasibility of transradial approach for chronic total occlusion (CTO) percutaneous coronary intervention. The aim of the current study is to assess technical success, complication rates, and procedural efficiency in fully transradial approach (fTRA) and transfemoral approach (TFA) in a large prospective European registry adopting the hybrid algorithm for CTO percutaneous coronary intervention (Registry of CrossBoss and Hybrid Procedures in France, the Netherlands, Belgium and United Kingdom, RECHARGE registry). We analyzed 1253 CTO percutaneous coronary intervention procedures performed according to the hybrid protocol in 17 European centers, comparing fTRA (single or biradial access) and TFA (single or bifemoral or combined radial and femoral access). fTRA was applied in 306 (24%) and TFA in 947 (76%) cases. The average Japanese CTO score was 2.1±1.2 in fTRA and 2.3±1.1 in TFA ( P =0.06). Technical success was achieved in 85% in fTRA and 86% in TFA ( P =0.51). Technical success was comparable for fTRA and TFA in different Japanese CTO score subgroups after multivariable analysis and after propensity adjustment. In-hospital major adverse cardiac and cerebral events occurred in 2.0% in fTRA and 2.9% in TFA ( P =0.40). Major access site bleeding occurred in 0.3% in fTRA and 0.5% in TFA ( P =0.66). fTRA compared with TFA had similar procedural duration (80 minutes [54-120 minutes] versus 90 minutes [60-121 minutes]; P =0.07), similar radiation dose (dose area product 89 Gray×cm 2 [52-163 Gray×cm 2 ] versus 101 Gray×cm 2 [59-171 Gray×cm 2 ]; P =0.06), and lower contrast agent use (200 mL [150-310 mL] versus 250 mL [200-350 mL]; P <0.01). fTRA CTO percutaneous coronary intervention is a valid alternative to TFA with a high rate of success, low complication rates, and no decrease in procedural efficiency. © 2017 American Heart Association, Inc.

Primary care physicians’ experiences with electronic medical records

PubMed Central

Ludwick, Dave; Manca, Donna; Doucette, John

2010-01-01

OBJECTIVE To understand how remuneration and care setting affect the implementation of electronic medical records (EMRs). DESIGN Semistructured interviews were used to illicit descriptions from community-based family physicians (paid on a fee-for-service basis) and from urban, hospital, and academic family physicians (remunerated via alternative payment models or sessional pay for activities pertaining to EMR implementation). SETTING Small suburban community and large urban-, hospital-, and academic-based family medicine clinics in Alberta. All participants were supported by a jurisdictional EMR certification funding mechanism. PARTICIPANTS Physicians who practised in 1 or a combination of the above settings and had experience implementing and using EMRs. METHODS Purposive and maximum variation sampling was used to obtain descriptive data from key informants through individually conducted semistructured interviews. The interview guide, which was developed from key findings of our previous literature review, was used in a previous study of community-based family physicians on this same topic. Field notes were analyzed to generate themes through a comparative immersion approach. MAIN FINDINGS Physicians in urban, hospital, and academic settings leverage professional working relationships to investigate EMRs, a resource not available to community physicians. Physicians in urban, hospital, and academic settings work in larger interdisciplinary teams with a greater need for interdisciplinary care coordination, EMR training, and technical support. These practices were able to support the cost of project management or technical support resources. These physicians followed a planned system rollout approach compared with community physicians who installed their systems quickly and required users to transition to the new system immediately. Electronic medical records did not increase, or decrease, patient throughput. Physicians developed ways of including patients in the note-taking process. CONCLUSION We studied physicians’ procurement approaches under various payment models. Our findings do not suggest that one remuneration approach supports EMR adoption any more than another. Rather, this study suggests that stronger physician professional networks used in information gathering, more complete training, and in-house technical support might be more influential than remuneration in facilitating the EMR adoption experience. PMID:20090083

Technical and economic feasibility of alternative fuel use in process heaters and small boilers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-02-01

The technical and economic feasibility of using alternate fuels - fuels other than oil and natural gas - in combustors not regulated by the Powerplant and Industrial Fuel Use Act of 1978 (FUA) was evaluated. FUA requires coal or alternate fuel use in most large new boilers and in some existing boilers. Section 747 of FUA authorizes a study of the potential for reduced oil and gas use in combustors not subject to the act: small industrial boilers with capacities less than 100 MMBtu/hr, and process heat applications. Alternative fuel use in combustors not regulated by FUA was examined andmore » the impact of several measures to encourage the substitution of alternative fuels in these combustors was analyzed. The primary processes in which significant fuel savings can be achieved are identified. Since feedstock uses of oil and natural gas are considered raw materials, not fuels, feedstock applications are not examined in this analysis. The combustors evaluated in this study comprise approximately 45% of the fuel demand projected in 1990. These uses would account for more than 3.5 million barrels per day equivalent fuel demand in 1990.« less

76 FR 18649 - Technical Revisions to Actuarial Information on Form 5500 Annual Return/Report for Pension Plans...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

... DEPARTMENT OF LABOR Employee Benefits Security Administration 29 CFR Part 2520 Technical Revisions... Alternatives Under Pension Relief Act of 2010 AGENCY: Employee Benefits Security Administration, Labor. ACTION... 5500 Annual Return/Report of Employee Benefit Plan have been adopted in IRS Notice 2010-83 (2010-51 I.R...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayberry, J.; Stelle, S.; O`Brien, M.

The Mixed Waste Integrated Program Logic Diagram was developed to provide technical alternative for mixed wastes projects for the Office of Technology Development`s Mixed Waste Integrated Program (MWIP). Technical solutions in the areas of characterization, treatment, and disposal were matched to a select number of US Department of Energy (DOE) treatability groups represented by waste streams found in the Mixed Waste Inventory Report (MWIR).

Analyzing the Reliability of the easyCBM Reading Comprehension Measures: Grade 5. Technical Report #1204

ERIC Educational Resources Information Center

Park, Bitnara Jasmine; Irvin, P. Shawn; Lai, Cheng-Fei; Alonzo, Julie; Tindal, Gerald

2012-01-01

In this technical report, we present the results of a reliability study of the fifth-grade multiple choice reading comprehension measures available on the easyCBM learning system conducted in the spring of 2011. Analyses include split-half reliability, alternate form reliability, person and item reliability as derived from Rasch analysis,…

Analyzing the Reliability of the easyCBM Reading Comprehension Measures: Grade 2. Technical Report #1201

ERIC Educational Resources Information Center

Lai, Cheng-Fei; Irvin, P. Shawn; Alonzo, Julie; Park, Bitnara Jasmine; Tindal, Gerald

2012-01-01

In this technical report, we present the results of a reliability study of the second-grade multiple choice reading comprehension measures available on the easyCBM learning system conducted in the spring of 2011. Analyses include split-half reliability, alternate form reliability, person and item reliability as derived from Rasch analysis,…

Analyzing the Reliability of the easyCBM Reading Comprehension Measures: Grade 4. Technical Report #1203

ERIC Educational Resources Information Center

Park, Bitnara Jasmine; Irvin, P. Shawn; Alonzo, Julie; Lai, Cheng-Fei; Tindal, Gerald

2012-01-01

In this technical report, we present the results of a reliability study of the fourth-grade multiple choice reading comprehension measures available on the easyCBM learning system conducted in the spring of 2011. Analyses include split-half reliability, alternate form reliability, person and item reliability as derived from Rasch analysis,…

Analyzing the Reliability of the easyCBM Reading Comprehension Measures: Grade 6. Technical Report #1205

ERIC Educational Resources Information Center

Irvin, P. Shawn; Alonzo, Julie; Park, Bitnara Jasmine; Lai, Cheng-Fei; Tindal, Gerald

2012-01-01

In this technical report, we present the results of a reliability study of the sixth-grade multiple choice reading comprehension measures available on the easyCBM learning system conducted in the spring of 2011. Analyses include split-half reliability, alternate form reliability, person and item reliability as derived from Rasch analysis,…

Analyzing the Reliability of the easyCBM Reading Comprehension Measures: Grade 7. Technical Report #1206

ERIC Educational Resources Information Center

Irvin, P. Shawn; Alonzo, Julie; Lai, Cheng-Fei; Park, Bitnara Jasmine; Tindal, Gerald

2012-01-01

In this technical report, we present the results of a reliability study of the seventh-grade multiple choice reading comprehension measures available on the easyCBM learning system conducted in the spring of 2011. Analyses include split-half reliability, alternate form reliability, person and item reliability as derived from Rasch analysis,…

Analyzing the Reliability of the easyCBM Reading Comprehension Measures: Grade 3. Technical Report #1202

ERIC Educational Resources Information Center

Lai, Cheng-Fei; Irvin, P. Shawn; Park, Bitnara Jasmine; Alonzo, Julie; Tindal, Gerald

2012-01-01

In this technical report, we present the results of a reliability study of the third-grade multiple choice reading comprehension measures available on the easyCBM learning system conducted in the spring of 2011. Analyses include split-half reliability, alternate form reliability, person and item reliability as derived from Rasch analysis,…

The Pacific Northwest region vegetation and monitoring system.

Treesearch

Timothy A. Max; Hans T. Schreuder; John W. Hazard; Daniel D. Oswald; John Teply; Jim. Alegria

1996-01-01

A grid sampling strategy was adopted for broad-scale inventory and monitoring of forest and range vegetation on National Forest System lands in the Pacific North-west Region, USDA Forest Service. This paper documents the technical details of the adopted design and discusses alternative sampling designs that were considered. A less technical description of the selected...

Web Based Technical Problem Solving for Enhancing Writing Skills of Secondary Vocational Students

ERIC Educational Resources Information Center

Papantoniou, Eleni; Hadzilacos, Thanasis

2017-01-01

We discuss some aspects of a pilot e-learning technical writing course addressed to 11th grade vocational high school students in Greece. The application of this alternative teaching intervention stemmed from the researcher-instructor's reflections relating to the integration of a problem based e-pedagogy that aims not just to familiarize students…

Creating an Alternative Developmental Math Pathway at Delaware Technical Community College

ERIC Educational Resources Information Center

Bradley, John Patrick, Jr.

2017-01-01

Developmental mathematics pass rates at Delaware Technical Community College (DTCC) have remained the same or decreased for a number of years despite two different math curriculum redesigns. They hover around 50 percent or below at each campus, even after the implementation of a second redesign this past Fall 2016 semester. The first redesign…

Technical Communication in the 21st Century: Where Are We Going?

ERIC Educational Resources Information Center

Killingsworth, M. Jimmie

1999-01-01

Explores how technical communicators arrive at their attitudes toward the future and the effects of such attitudes toward current practice. Argues for a critically informed, open-minded approach to the future, an approach that encourages an honest self-criticism within the discipline of technical communication. (SC)

Fly-By-Light/Power-By-Wire Requirements and Technology Workshop

NASA Technical Reports Server (NTRS)

Baker, Robert L. (Editor); Pitts, Felix L. (Editor)

1992-01-01

The results of the Fly-By-Light/Power-By-Wire (FBL/PBW) Workshop held on March 17-19, 1992, at the NASA Langley Research Center are presented. The FBL/PBW program is a joint NASA LeRC/LaRC effort to develop the technology base for confident application of integrated FBL/PBW systems to transport aircraft. The objectives of the workshop were to ascertain the FBL/PBW program technical requirements and satisfy the requirements and needs from the industry viewpoint, provide a forum for presenting and documenting alternative technical approaches which satisfy the requirements, and assess the plan adequacy in accomplishing plan objectives, aims, and technology transfer. Areas addressed were: optical sensor systems, power-by-wire systems, FBL/PBW fault-tolerant architectures, electromagnetic environment assessment, and system integration and demonstration. The workshop consisted of an introductory meeting, a 'keynote' presentation, a series of individual panel sessions covering the above areas, with midway presentations by the panel chairpersons, followed by a final summarizing/integrating session by the individual panels, and a closing plenary session summarizing the results of the workshop.

Development of decision- making mechanism in engineering design of phased coal mines technical upgrade

NASA Astrophysics Data System (ADS)

Kulak, V. Yu; Petrova, T. V.; Novichikhin, A. V.

2017-09-01

The approach to a choice of a new mine design and technical upgrade of operating coal mines is substantiated. The choice of the option is made in the following way: the elements of the mine technological system are defined, for each element of the system two levels of costs are allocated - capital and operational; a graph of alternative options of the system is formed by matrix enumeration taking into account the possibility of simultaneous application of different elements, up to 10 000 scenarios are formed; capital and operating costs of options are estimated in the form of coefficients as the cost-to-cost ratio in the base variant, which has already been implemented and the costs of which are already known; ranking of the options at the level of costs and the definition of the 10 preferred are performed. It is established that the application of partial enumeration allows the costs relative to the base variant to be reduced by 10 %; the main constraint of costs reduction is the need to comply with all conditions that ensure industrial safety.

Simulation of the AC corona phenomenon with experimental validation

NASA Astrophysics Data System (ADS)

Villa, Andrea; Barbieri, Luca; Marco, Gondola; Malgesini, Roberto; Leon-Garzon, Andres R.

2017-11-01

The corona effect, and in particular the Trichel phenomenon, is an important aspect of plasma physics with many technical applications, such as pollution reduction, surface and medical treatments. This phenomenon is also associated with components used in the power industry where it is, in many cases, the source of electro-magnetic disturbance, noise and production of undesired chemically active species. Despite the power industry to date using mainly alternating current (AC) transmission, most of the studies related to the corona effect have been carried out with direct current (DC) sources. Therefore, there is technical interest in validating numerical codes capable of simulating the AC phenomenon. In this work we describe a set of partial differential equations that are comprehensive enough to reproduce the distinctive features of the corona in an AC regime. The model embeds some selectable chemical databases, comprising tens of chemical species and hundreds of reactions, the thermal dynamics of neutral species and photoionization. A large set of parameters—deduced from experiments and numerical estimations—are compared, to assess the effectiveness of the proposed approach.

Environmental Assessment: Clear Zone and Accident Potential Zone Selective Tree Removal

DTIC Science & Technology

2011-05-25

PROPOSED ACTION The Proposed Action would occur within the CZ and APZs north and south of the runway. The overall area is undeveloped wetland and...existing runway. Therefore, there is no practicable alternative to conducting the action in floodplain/ wetland areas. Three technical alternatives for...or removal would be required. Alternative 3 was eliminated because leaving woody debris in wetlands would not meet U.S. Army Corps of Engineers

Alternatives for jet engine control

NASA Technical Reports Server (NTRS)

Sain, M. K.

1983-01-01

The technical progress of researches on alternatives for jet engine control, is reported. The principal new activities involved the initial testing of an input design method for choosing the inputs to a non-linear system to aid the approximation of its tensor parameters, and the beginning of order reduction studies designed to remove unnecessary monomials from tensor models.

Proletarianization of English Language Teaching: Iranian EFL Teachers and Their Alternative Role as Transformative Intellectuals

ERIC Educational Resources Information Center

Safari, Parvin

2017-01-01

In the field of English Language Teaching (ELT), attention has been shifted toward the alternative role of teachers as transformative intellectuals whereby transformation in teaching occurs from control and technical operations to criticism and intellectual reflection. This role enables teachers to focus on marginalized students' lived experiences…

Energy conversion alternatives study

NASA Technical Reports Server (NTRS)

Shure, L. T.

1979-01-01

Comparison of coal based energy systems is given. Study identifies and compares various advanced energy conversion systems using coal or coal derived fuels for baselaoad electric power generation. Energy Conversion Alternatives Study (ECAS) reports provede government, industry, and general public with technically consistent basis for comparison of system's options of interest for fossilfired electric-utility application.

FAA Center of Excellence for Alternative Jet Fuels & Environment : Annual Technical Report : December, 2016 : For the period September 13, 2013 - September 30, 2015

DOT National Transportation Integrated Search

2015-12-01

This report covers the period between the initial establishment of the FAA Center of Excellence for Alternative Jet Fuels and Environment on September 13, 2013 through September 30, 2015. The Center was established by the authority of FAA solicitatio...

Total Program Efficacy: A Comparison of Traditionally and Alternatively Certified Agriculture Teachers

ERIC Educational Resources Information Center

Duncan, Dennis W.; Ricketts, John C.

2008-01-01

The purpose of this study was to determine agriculture teachers' perceived levels of efficacy as they relate to managing the total program of agricultural education, both for traditionally and alternatively certified teachers. The constructs used in this study were technical content, FFA/leadership development/SAE, teaching and learning, and…

Alternative Films for Making Presentation Slides for the Occasional User.

ERIC Educational Resources Information Center

Hunt, Harold R., Jr.

1985-01-01

As alternatives to the well-known Kodak Kodalith film for making presentation slides, suggests using Kodak Technical Pan Film, 2415 and Kodak Precision Fine Film LPD4. Although less known, both films are capable of making excellent quality slides with minimum effort and, for the occasional user, offer advantages over the Kodalith-Diazochrome…

75 FR 54163 - Office of the Secretary: Renewal of the Lake Champlain Sea Lamprey Control Alternatives Workgroup

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... (Workgroup) for 2 years. The Workgroup provides an opportunity for stakeholders to give policy and technical advice on efforts to develop and implement sea lamprey control techniques alternative to lampricides in... Workgroup provides recommendations and advice to the Cooperative on: Feasible and appropriate sea lamprey...

A Study on Becoming an Alternatively Certified Career and Technical Educator

ERIC Educational Resources Information Center

Cotton-Flanagan, Kymberli A.

2011-01-01

This mixed method study examined the perspectives of twelve practicing high school CTE teachers engaged in a newly approved university model for alternative certification. Using Creswell's (2008) Sequential Exploratory Design and the lens of adult learning theory as established in Knowles' (1970) Theory of Andragogy, this study examines how…

10 CFR 504.2 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS § 504.2 Purpose and scope. (a) Sections... to the unit's technical capability and financial feasibility to use coal or another alternate fuel as..., 91 Stat. 565 (42 U.S.C. 7101 et seq.); Powerplant and Industrial Fuel Use Act of 1978, Pub. L. 95-620...

10 CFR 61.54 - Alternative requirements for design and operations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements for... other than those set forth in §§ 61.51 through 61.53 for the segregation and disposal of waste and for...

10 CFR 61.54 - Alternative requirements for design and operations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements for... other than those set forth in §§ 61.51 through 61.53 for the segregation and disposal of waste and for...

10 CFR 61.54 - Alternative requirements for design and operations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements for... other than those set forth in §§ 61.51 through 61.53 for the segregation and disposal of waste and for...

10 CFR 61.54 - Alternative requirements for design and operations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements for... other than those set forth in §§ 61.51 through 61.53 for the segregation and disposal of waste and for...

10 CFR 61.54 - Alternative requirements for design and operations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements for... other than those set forth in §§ 61.51 through 61.53 for the segregation and disposal of waste and for...

Quality Concerns in Technical Education in India: A Quantifiable Quality Enabled Model

ERIC Educational Resources Information Center

Gambhir, Victor; Wadhwa, N. C.; Grover, Sandeep

2016-01-01

Purpose: The paper aims to discuss current Technical Education scenarios in India. It proposes modelling the factors affecting quality in a technical institute and then applying a suitable technique for assessment, comparison and ranking. Design/methodology/approach: The paper chose graph theoretic approach for quantification of quality-enabled…

Deriving preference order of post-mining land-uses through MLSA framework: application of an outranking technique

NASA Astrophysics Data System (ADS)

Soltanmohammadi, Hossein; Osanloo, Morteza; Aghajani Bazzazi, Abbas

2009-08-01

This study intends to take advantage of a previously developed framework for mined land suitability analysis (MLSA) consisted of economical, social, technical and mine site factors to achieve a partial and also a complete pre-order of feasible post-mining land-uses. Analysis by an outranking multi-attribute decision-making (MADM) technique, called PROMETHEE (preference ranking organization method for enrichment evaluation), was taken into consideration because of its clear advantages on the field of MLSA as compared with MADM ranking techniques. Application of the proposed approach on a mined land can be completed through some successive steps. First, performance of the MLSA attributes is scored locally by each individual decision maker (DM). Then the assigned performance scores are normalized and the deviation amplitudes of non-dominated alternatives are calculated. Weights of the attributes are calculated by another MADM technique namely, analytical hierarchy process (AHP) in a separate procedure. Using the Gaussian preference function beside the weights, the preference indexes of the land-use alternatives are obtained. Calculation of the outgoing and entering flows of the alternatives and one by one comparison of these values will lead to partial pre-order of them and calculation of the net flows, will lead to a ranked preference for each land-use. At the final step, utilizing the PROMETHEE group decision support system which incorporates judgments of all the DMs, a consensual ranking can be derived. In this paper, preference order of post-mining land-uses for a hypothetical mined land has been derived according to judgments of one DM to reveal applicability of the proposed approach.

Modular space station phase B extension period executive summary

NASA Technical Reports Server (NTRS)

Tischler, A. A.; Could, C. L.

1972-01-01

A narrative summary is presented of technical, programmatic, and planning information developed during the space station definition study extension period. The modular space station is emphasized, but tasks pertaining to shuttle sorties missions and information management advanced development are included. A series of program options considering technical, schedule, and programmatic alternatives to the baseline program are defined and evaluated.

10 CFR 504.8 - Prohibitions against excessive use of petroleum or natural gas in mixtures-certifying powerplants.

Code of Federal Regulations, 2013 CFR

2013-01-01

... primary energy source. In assessing whether the unit is technically capable of using a mixture of petroleum or natural gas and coal or another alternate fuel as a primary energy source, for purposes of this... technically capable of using the mixture as a primary energy source under § 504.6(c), this certification...

10 CFR 504.8 - Prohibitions against excessive use of petroleum or natural gas in mixtures-certifying powerplants.

Code of Federal Regulations, 2014 CFR

2014-01-01

... primary energy source. In assessing whether the unit is technically capable of using a mixture of petroleum or natural gas and coal or another alternate fuel as a primary energy source, for purposes of this... technically capable of using the mixture as a primary energy source under § 504.6(c), this certification...

10 CFR 504.8 - Prohibitions against excessive use of petroleum or natural gas in mixtures-certifying powerplants.

Code of Federal Regulations, 2012 CFR

2012-01-01

... primary energy source. In assessing whether the unit is technically capable of using a mixture of petroleum or natural gas and coal or another alternate fuel as a primary energy source, for purposes of this... technically capable of using the mixture as a primary energy source under § 504.6(c), this certification...

The Treatment of Assets and Income From Assets in Income-Conditioned Government Benefit Programs; Technical Papers.

ERIC Educational Resources Information Center

Wisconsin Univ., Madison. Inst. for Research on Poverty.

These technical papers were presented at the Conference on Treatment of Assets and Income from Assets in Income Conditioned Programs. Six papers dealing with current and alternative treatments of assets and income from assets in programs that offer both cash and noncash benefits were presented. The first three authors reviewed the network of rules…

A Model University-School District-Teacher Education Center Alternative Teacher Training Program for Preparing and Certifying Non-Degree Vocational Teachers. A Collaborative Design.

ERIC Educational Resources Information Center

Bouchie, Mary Ellen; Vos, Robert

Vocational teachers for industrial and health occupations programs are usually recruited and selected directly from industry based upon their work experience, craft skills, and other technical criteria. This procedure provides schools with technically competent instructors who have little idea of how to teach. The certification requirements of…

25 CFR 30.111 - When should the tribal governing body or school board request technical assistance?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false When should the tribal governing body or school board... When should the tribal governing body or school board request technical assistance? In order to maximize the time the tribal governing body or school board has to develop an alternative definition of AYP...

Identifying Technical Vocabulary

ERIC Educational Resources Information Center

Chung, Teresa Mihwa; Nation, Paul

2004-01-01

This study compared four different approaches to identifying technical words in an anatomy text. The first approach used a four step rating scale, and was used as the comparison for evaluating the other three approaches. It had a high degree of reliability. The least successful approach was that using clues provided by the writer such as labels in…

From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing.

PubMed

Marinov, Georgi K; Williams, Brian A; McCue, Ken; Schroth, Gary P; Gertz, Jason; Myers, Richard M; Wold, Barbara J

2014-03-01

Single-cell RNA-seq mammalian transcriptome studies are at an early stage in uncovering cell-to-cell variation in gene expression, transcript processing and editing, and regulatory module activity. Despite great progress recently, substantial challenges remain, including discriminating biological variation from technical noise. Here we apply the SMART-seq single-cell RNA-seq protocol to study the reference lymphoblastoid cell line GM12878. By using spike-in quantification standards, we estimate the absolute number of RNA molecules per cell for each gene and find significant variation in total mRNA content: between 50,000 and 300,000 transcripts per cell. We directly measure technical stochasticity by a pool/split design and find that there are significant differences in expression between individual cells, over and above technical variation. Specific gene coexpression modules were preferentially expressed in subsets of individual cells, including one enriched for mRNA processing and splicing factors. We assess cell-to-cell variation in alternative splicing and allelic bias and report evidence of significant differences in splice site usage that exceed splice variation in the pool/split comparison. Finally, we show that transcriptomes from small pools of 30-100 cells approach the information content and reproducibility of contemporary RNA-seq from large amounts of input material. Together, our results define an experimental and computational path forward for analyzing gene expression in rare cell types and cell states.

Socio-technical transition as a co-evolutionary process: Innovation and the role of niche markets in the transition to motor vehicles

NASA Astrophysics Data System (ADS)

Birky, Alicia K.

2008-10-01

Significant reductions in greenhouse emissions from personal transportation will require a transition to an alternative technology regime based on renewable energy sources. Two bodies of research, the quasi-evolutionary (QE) model and the multi-level perspective (MLP) assert that processes within niches play a fundamental role in such transitions. This research asks whether the description of transitions based on this niche hypothesis and its underlying assumptions is consistent with the historical U.S. transition to motor vehicles at the beginning of the 20th century. Unique to this dissertation is the combination of the perspective of the entrepreneur with co-evolutionary approaches to socio-technical transitions. This approach is augmented with concepts from the industry life-cycle model and with a taxonomy of mechanisms of learning. Using this analytic framework, I examine specifically the role of entrepreneurial behavior and processes within and among firms in the co-evolution of technologies and institutions during the transition to motor vehicles. I find that niche markets played an important role in the development of the technology, institutions, and the industry. However, I also find that the diffusion of the automobile is not consistent with the niche hypothesis in the following ways: (1) product improvements and cost reductions were not realized in niche markets, but were achieved simultaneously with diffusion into mass markets; (2) in addition to learning-by-doing and learning-by-interacting with users, knowledge spillovers and interacting with suppliers were critical in this process; (3) cost reductions were not automatic results of expanding markets, but rather arose from the strategies of entrepreneurs based on personal perspectives and values. This finding supports the use of a behavioral approach with a micro-focus in the analysis of socio-technical change. I also find that the emergence and diffusion of the motor vehicle can only be understood by considering the combination of developments and processes in multiple regimes, within niches, and within the wider technical, institutional, and ecological complex (TIEC). For the automobile, the process of regime development was more consistent with a fit-stretch pattern of gradual unfolding and adaptation than one of niche proliferation and rapid regime renewal described in the literature.

Hanford Site Composite Analysis Technical Approach Description: Vadose Zone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, M. D.; Nichols, W. E.; Ali, A.

2017-10-30

The U.S. Department of Energy (DOE) in DOE O 435.1 Chg. 1, Radioactive Waste Management, and DOE M 435.1 Chg 1, Radioactive Waste Management Manual, requires the preparation and maintenance of a composite analysis (CA). The primary purpose of the CA is to provide a reasonable expectation that the primary public dose limit is not likely to be exceeded by multiple source terms that may significantly interact with plumes originating at a low-level waste disposal facility. The CA is used to facilitate planning and land use decisions that help assure disposal facility authorization will not result in long-term compliance problems;more » or, to determine management alternatives, corrective actions, or assessment needs, if potential problems are identified.« less

Quantum information processing with a travelling wave of light

NASA Astrophysics Data System (ADS)

Serikawa, Takahiro; Shiozawa, Yu; Ogawa, Hisashi; Takanashi, Naoto; Takeda, Shuntaro; Yoshikawa, Jun-ichi; Furusawa, Akira

2018-02-01

We exploit quantum information processing on a traveling wave of light, expecting emancipation from thermal noise, easy coupling to fiber communication, and potentially high operation speed. Although optical memories are technically challenging, we have an alternative approach to apply multi-step operations on traveling light, that is, continuous-variable one-way computation. So far our achievement includes generation of a one-million-mode entangled chain in time-domain, mode engineering of nonlinear resource states, and real-time nonlinear feedforward. Although they are implemented with free space optics, we are also investigating photonic integration and performed quantum teleportation with a passive liner waveguide chip as a demonstration of entangling, measurement, and feedforward. We also suggest a loop-based architecture as another model of continuous-variable computing.

Statistical process control in nursing research.

PubMed

Polit, Denise F; Chaboyer, Wendy

2012-02-01

In intervention studies in which randomization to groups is not possible, researchers typically use quasi-experimental designs. Time series designs are strong quasi-experimental designs but are seldom used, perhaps because of technical and analytic hurdles. Statistical process control (SPC) is an alternative analytic approach to testing hypotheses about intervention effects using data collected over time. SPC, like traditional statistical methods, is a tool for understanding variation and involves the construction of control charts that distinguish between normal, random fluctuations (common cause variation), and statistically significant special cause variation that can result from an innovation. The purpose of this article is to provide an overview of SPC and to illustrate its use in a study of a nursing practice improvement intervention. Copyright © 2011 Wiley Periodicals, Inc.

Cytogenetics in the management of multiple myeloma: an update by the Groupe francophone de cytogénétique hématologique (GFCH).

PubMed

Daudignon, Agnès; Quilichini, Benoît; Ameye, Geneviève; Poirel, Hélène; Bastard, Christian; Terré, Christine

2016-10-01

Cytogenetics of multiple myeloma has evolved in recent years by the emergence of Interphasic fluorescence in situ hybridization (FISH) performed on sorted plasma cells detecting abnormalities independently of a proliferative and infiltrative index. Cytogenetic analysis plays a major part in the risk stratification of myeloma diagnosis due to prognostic impact of various cytogenetic abnormalities as well as to the association between emerging therapeutic approaches in MM. Thus, practice guidelines now recommend interphasic FISH or alternative molecular technics as the initial analysis for multiple myeloma. The Groupe francophone de cytogénétique hématologique (GFCH) proposes in this issue an update of managing multiple myeloma cytogenetics.

Automatically updating predictive modeling workflows support decision-making in drug design.

PubMed

Muegge, Ingo; Bentzien, Jörg; Mukherjee, Prasenjit; Hughes, Robert O

2016-09-01

Using predictive models for early decision-making in drug discovery has become standard practice. We suggest that model building needs to be automated with minimum input and low technical maintenance requirements. Models perform best when tailored to answering specific compound optimization related questions. If qualitative answers are required, 2-bin classification models are preferred. Integrating predictive modeling results with structural information stimulates better decision making. For in silico models supporting rapid structure-activity relationship cycles the performance deteriorates within weeks. Frequent automated updates of predictive models ensure best predictions. Consensus between multiple modeling approaches increases the prediction confidence. Combining qualified and nonqualified data optimally uses all available information. Dose predictions provide a holistic alternative to multiple individual property predictions for reaching complex decisions.

The Role of Lunar Development in Human Exploration of the Solar System

NASA Technical Reports Server (NTRS)

Mendell, Wendell W.

1999-01-01

Human exploration of the solar system can be said to have begun with the Apollo landings on the Moon. The Apollo Project was publicly funded with the narrow technical objective of landing human beings on the Moon. The transportation and life support systems were specialized technical designs, developed in a project management environment tailored to that objective. Most scenarios for future human exploration assume a similar long-term commitment of public funds to a narrowly focused project managed by a large, monolithic organization. Advocates of human exploration of space have not yet been successful in generating the political momentum required to initiate such a project to go to the Moon or to Mars. Alternative scenarios of exploration may relax some or all of the parameters of organizational complexity, great expense, narrow technical focus, required public funding, and control by a single organization. Development of the Moon using private investment is quite possibly a necessary condition for alternative scenarios to succeed.

A renaissance in residential behavior analysis? A historical perspective and a better way to help people with challenging behavior

PubMed Central

Holburn, Steve

1997-01-01

After a slow start, the popularity of applied behavior analysis for people with severe behavior problems peaked in the 1970s and was then battered down by the effects of methodological behaviorism, the aversives controversy, overregulation, and the inherent limitations of congregate living. Despite the ethical, technical, and conceptual advancements in behavior analysis, many people with challenging behavior live in futile environments in which the behavior analyst can only tinker. A radically behavioristic approach has become available that has the power to change these conditions, to restore the reciprocity necessary for new learning, and to bring residential behavior analysts more in contact with the contingencies of helping and teaching. The approach is consistent with alternatives that behaviorists have suggested for years to improve the image and effectiveness of applied behavior analysis, although it will take the behaviorist far from the usual patterns of practice. Finally, the approach promotes its own survival by promoting access to interlocking organizational contingencies, but its antithetical nature presents many conceptual and practical challenges to agency adoption. PMID:22478282

[TECHNIQUES IN MITRAL VALVE REPAIR VIA A MINIMALLY INVASIVE APPROACH].

PubMed

Ito, Toshiaki

2016-03-01

In mitral valve repair via a minimally invasive approach, resection of the leaflet is technically demanding compared with that in the standard approach. For resection and suture repair of the posterior leaflet, premarking of incision lines is recommended for precise resection. As an alternative to resection and suture, the leaflet-folding technique is also recommended. For correction of prolapse of the anterior leaflet, neochordae placement with the loop technique is easy to perform. Premeasurement with transesophageal echocardiography or intraoperative measurement using a replica of artificial chordae is useful to determine the appropriate length of the loops. Fine-tuning of the length of neochordae is possible by adding a secondary fixation point on the leaflet if the loop is too long. If the loop is too short, a CV5 Gore-Tex suture can be passed through the loop and loosely tied several times to stack the knots, with subsequent fixation to the edge of the leaflet. Finally, skill in the mitral valve replacement technique is necessary as a back-up for surgeons who perform minimally invasive mitral valve repair.

Phenotypic screening in cancer drug discovery - past, present and future.

PubMed

Moffat, John G; Rudolph, Joachim; Bailey, David

2014-08-01

There has been a resurgence of interest in the use of phenotypic screens in drug discovery as an alternative to target-focused approaches. Given that oncology is currently the most active therapeutic area, and also one in which target-focused approaches have been particularly prominent in the past two decades, we investigated the contribution of phenotypic assays to oncology drug discovery by analysing the origins of all new small-molecule cancer drugs approved by the US Food and Drug Administration (FDA) over the past 15 years and those currently in clinical development. Although the majority of these drugs originated from target-based discovery, we identified a significant number whose discovery depended on phenotypic screening approaches. We postulate that the contribution of phenotypic screening to cancer drug discovery has been hampered by a reliance on 'classical' nonspecific drug effects such as cytotoxicity and mitotic arrest, exacerbated by a paucity of mechanistically defined cellular models for therapeutically translatable cancer phenotypes. However, technical and biological advances that enable such mechanistically informed phenotypic models have the potential to empower phenotypic drug discovery in oncology.

Technical Subjects in Secondary Schools

ERIC Educational Resources Information Center

Howard, A. E.

2008-01-01

Purpose: This paper aims to examine technical education in various types of secondary schools, and suggests three levels of technical courses to be taught in secondary schools. Design/methodology/approach: The paper discusses the differences between technical schools and colleges, and vocational technical courses taught in "academic"…

Alternatives to clearcutting of old growth in southeast Alaska.

Treesearch

Sally. Duncan

1999-01-01

This issue of Science Findings examines the results of a study designed to provide a broad array of silvicultural options for land managers. Pacific Northwest Research Station scientist Mike McClellan is leading the study and has found that timber harvesting by using alternatives to clearcutting is viable in the current marketplace and technically feasible across a...

10 CFR 504.7 - Prohibition against excessive use of petroleum or natural gas in mixtures-electing powerplants.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) ALTERNATE FUELS EXISTING POWERPLANTS § 504.7 Prohibition against excessive use of petroleum or natural gas... technically and financially feasible for a unit to use a mixture of petroleum or natural gas and an alternate... natural gas, or both, in amounts exceeding the minimum amount necessary to maintain reliability of...

2014 Guide to Calculating School Improvement Ratings for Alternative Schools and ESE Centers

ERIC Educational Resources Information Center

Florida Department of Education, 2014

2014-01-01

The purpose of this technical assistance paper is to provide a description of the procedures used to determine school improvement ratings for alternative schools and ESE centers for the most recently completed school year. School improvement ratings are part of Florida's school accountability system, which originated with the Florida Legislature's…

75 FR 76055 - Nebraska Public Power District Cooper Nuclear Station; Notice of Issuance of Renewed Facility...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... Additional 20-Year Period and Record of Decision Notice is hereby given that the U.S. Nuclear Regulatory... its technical specifications. The notice also serves as the record of decision for the renewal of... from coal, natural gas, combination of alternatives, and the no action alternative. The factors...

A study of alternative designs for a system to concentrate carbon dioxide in a hydrogen-depolarized cell

NASA Technical Reports Server (NTRS)

1973-01-01

Experimental results are presented on alternative designs for a hydrogen depolarized cell to concentrate CO2 in spacecraft atmospheric control systems. Data cover technical problems, methods for solving these problems, and the suitability of such a cell for CO2 removal and control of atmospheric humidity during the flight mode.

FROM FIELD TO FUEL TANK: EXPLORING THE IMPLEMENTATION OF BIODIESEL AS A SUSTAINABLE ALTERNATIVE TO PETROLEUM DIESEL IN OREGON'S WILLAMETTE VALLEY

EPA Science Inventory

The technical challenge is to demonstrate the feasibility of the production and use of a renewable bio-based diesel fuel as an alternative to petroleum-based diesel. The innovative objectives of the project are to:

• Demonstrate the engineering and economic feasib...

Safety testing of acellular pertussis vaccines: Use of animals and 3Rs alternatives

PubMed Central

Hoonakker, Marieke; Arciniega, Juan; Hendriksen, Coenraad

2017-01-01

ABSTRACT The current test of acellular Bordetella pertussis (aP) vaccines for residual pertussis toxin (PTx) is the Histamine Sensitization test (HIST), based on the empirical finding that PTx sensitizes mice to histamine. Although HIST has ensured the safety of aP vaccines for years, it is criticized for the limited understanding of how it works, its technical difficulty, and for animal welfare reasons. To estimate the number of mice used worldwide for HIST, we surveyed major aP manufacturers and organizations performing, requiring, or recommending the test. The survey revealed marked regional differences in regulatory guidelines, including the number of animals used for a single test. Based on information provided by the parties surveyed, we estimated the worldwide number of mice used for testing to be 65,000 per year: ∼48,000 by manufacturers and ∼17,000 by national control laboratories, although the latter number is more affected by uncertainty, due to confidentiality policies. These animals covered the release of approximately 850 final lots and 250 in-process lots of aP vaccines yearly. Although there are several approaches for HIST refinement and reduction, we discuss why the efforts needed for validation and implementation of these interim alternatives may not be worthwhile, when there are several in vitro alternatives in various stages of development, some already fairly advanced. Upon implementation, one or more of these replacement alternatives can substantially reduce the number of animals currently used for the HIST, although careful evaluation of each alternative's mechanism and its suitable validation will be necessary in the path to implementation. PMID:28857652

Safety testing of acellular pertussis vaccines: Use of animals and 3Rs alternatives.

PubMed

Hoonakker, Marieke; Arciniega, Juan; Hendriksen, Coenraad

2017-11-02

The current test of acellular Bordetella pertussis (aP) vaccines for residual pertussis toxin (PTx) is the Histamine Sensitization test (HIST), based on the empirical finding that PTx sensitizes mice to histamine. Although HIST has ensured the safety of aP vaccines for years, it is criticized for the limited understanding of how it works, its technical difficulty, and for animal welfare reasons. To estimate the number of mice used worldwide for HIST, we surveyed major aP manufacturers and organizations performing, requiring, or recommending the test. The survey revealed marked regional differences in regulatory guidelines, including the number of animals used for a single test. Based on information provided by the parties surveyed, we estimated the worldwide number of mice used for testing to be 65,000 per year: ∼48,000 by manufacturers and ∼17,000 by national control laboratories, although the latter number is more affected by uncertainty, due to confidentiality policies. These animals covered the release of approximately 850 final lots and 250 in-process lots of aP vaccines yearly. Although there are several approaches for HIST refinement and reduction, we discuss why the efforts needed for validation and implementation of these interim alternatives may not be worthwhile, when there are several in vitro alternatives in various stages of development, some already fairly advanced. Upon implementation, one or more of these replacement alternatives can substantially reduce the number of animals currently used for the HIST, although careful evaluation of each alternative's mechanism and its suitable validation will be necessary in the path to implementation.

Criminal Prohibition of Wrongful Re‑identification: Legal Solution or Minefield for Big Data?

PubMed

Phillips, Mark; Dove, Edward S; Knoppers, Bartha M

2017-12-01

The collapse of confidence in anonymization (sometimes also known as de-identification) as a robust approach for preserving the privacy of personal data has incited an outpouring of new approaches that aim to fill the resulting trifecta of technical, organizational, and regulatory privacy gaps left in its wake. In the latter category, and in large part due to the growth of Big Data-driven biomedical research, falls a growing chorus of calls for criminal and penal offences to sanction wrongful re-identification of "anonymized" data. This chorus cuts across the fault lines of polarized privacy law scholarship that at times seems to advocate privacy protection at the expense of Big Data research or vice versa. Focusing on Big Data in the context of biomedicine, this article surveys the approaches that criminal or penal law might take toward wrongful re-identification of health data. It contextualizes the strategies within their respective legal regimes as well as in relation to emerging privacy debates focusing on personal data use and data linkage and assesses the relative merit of criminalization. We conclude that this approach suffers from several flaws and that alternative social and legal strategies to deter wrongful re-identification may be preferable.

Probabilistic oil Outflow Analysis of Alternative Tanker Designs. Addendum 1.

DTIC Science & Technology

1992-10-01

National Technical Information Service, Springfield, Virginia 22161 Prepared for: U.S. Coast Guard Research and Development Center 1082 Shennecossett...Center 1082 Shennecossett Road Groton, CT 06340-6096 ±i Technical Report Documentation Page 1. Report No. 2. Government Accession No. 3. Recipient’s...Code Research and Development Center U.S. Coast Guard 1082 Shennecossett Road Office of Engineering, Logistics, Groton, Connecticut 06340-6096 and

Space transfer concepts and analysis for exploration missions

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.

1992-01-01

The current technical effort is part of the third phase of a broad-scoped and systematic study of space transfer concepts for human lunar and Mars missions. The study addressed the technical issues relating to the First Lunar Outpost (FLO) habitation vehicle with emphasis on the structure, power, life support system, and radiation environment for a baseline habitat with specific alternatives for the baseline.

Evaluation of Investments in Science, Technology and Innovation: Applying Scientific and Technical Human Capital Framework for Assessment of Doctoral Students in Cooperative Research Centers

ERIC Educational Resources Information Center

Leonchuk, Olena

2016-01-01

This dissertation builds on an alternative framework for evaluation of science, technology and innovation (STI) outcomes--the scientific & technical (S&T) human capital which was developed by Bozeman, Dietz and Gaughan (2001). At its core, this framework looks beyond simple economic and publication metrics and instead focuses on…

Environmental effects of dredging. Documentation of the efqual module for ADDAMS: Comparison of predicted effluent water quality with standards. Technical notes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palermo, M.R.; Schroeder, P.R.

This technical note describes a technique for comparison of the predicted quality of effluent discharged from confined dredged material disposal areas with applicable water quality standards. This note also serves as documentation of a computer program called EFQUAL written for that purpose as part of the Automated Dredging and Disposal Alternatives Management System (ADDAMS).

Wealth and the Accounting Period in the Measurement of Means. The Measure of Poverty, Technical Paper VI.

ERIC Educational Resources Information Center

Steuerle, Eugene; McClung, Nelson

This technical study is concerned with both the statistical and policy effects of alternative definitions of poverty which result when the definition of means is altered by varying the time period (accounting period) over which income is measured or by including in the measure of means not only realized income, but also unrealized income and…

Clean Cities Technical Assistance Project (Tiger Teams)

DOE Office of Scientific and Technical Information (OSTI.GOV)

This two-page fact sheet describes Clean Cities' technical assistance (Tiger Teams) capabilities and projects, both completed and ongoing. Tiger Teams are a critical element of the Clean Cities program, providing on-the-ground consultation to help inform program strategies. The knowledge Tiger Team experts gain from these experiences often helps inform other alternative fuels activities, such as needed research, codes and standards revisions, and new training resources.

Earth land landing alternatives: Lunar transportation system

NASA Technical Reports Server (NTRS)

Meyerson, Robert

1992-01-01

The objectives of this study are as follows: (1) develop a landing option such that it is a viable trade option for future NASA missions; (2) provide NASA programs with solid technical support in the landing systems area; (3) develop the technical staff; and (4) advance the state of landing systems technology to apply to future NASA missions. All results are presented in viewgraph format.

Internal Consistency of General Outcome Measures in Grades 1-8. Technical Report # 0915

ERIC Educational Resources Information Center

Anderson, Daniel; Tindal, Gerald; Alonzo, Julie

2009-01-01

We developed alternate forms of a math test for use in both screening students at risk of failure and monitoring their progress over time. In this technical report, we present results of the screener, used in the fall of 2009. The 48-item test was aligned to the National Council of Teachers of Mathematics (NCTM) Curriculum Focal Point Standards…

INTEREST AND INTELLECTUAL INDICES RELATED TO SUCCESSFUL AND NON-SUCCESSFUL MALE COLLEGE STUDENTS IN TECHNICAL AND ASSOCIATE DEGREE PROGRAMS. FINAL REPORT.

ERIC Educational Resources Information Center

HECKER, DONALD L.; TAYLOR, RONALD G.

THE PURPOSE OF THE PROJECT WAS TO STUDY THE DIFFERENCES AND SIMILARITIES IN INTEREST, ABILITY, AND PREVIOUS ACHIEVEMENT PATTERNS OF 941 MEN STUDENTS WHO ENROLLED IN VARIOUS TECHNICAL AND ASSOCIATE DEGREE 2-YEAR PROGRAMS AND TO DETERMINE WHICH VARIABLES COULD DIFFERENTIATE BETWEEN STUDENTS WHO COMPLETED, CHANGED TO AN ALTERNATE PROGRAM, OR WITHDREW…

Total Quality Management (TQM) in Self-Financed Technical Institutions: A Quality Function Deployment (QFD) and Force Field Analysis Approach

ERIC Educational Resources Information Center

Thakkar, Jitesh; Deshmukh, S. G.; Shastree, Anil

2006-01-01

Purpose: To explore the potential for adoption of TQM in self-financed technical institutions in the light of new demands and challenges posed by customers/students and society. Design/methodology/approach: The paper presents use of quality function deployment (QFD) which prioritizes technical requirements and correlates them with various…

Potential Alternatives Report for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes

NASA Technical Reports Server (NTRS)

Lewis, pattie

2011-01-01

Identifying and selecting alternative materials and technologies that have the potential to reduce the identified HazMats and hazardous air pollutants (HAPs), while incorporating sound corrosion prevention and control technologies, is a complicated task due to the fast pace at which new technologies emerge and rules change. The alternatives are identified through literature searches, electronic database and Internet searches, surveys, and/or personal and professional contacts. Available test data was then compiled on the proposed alternatives to determine if the materials meet the test objectives or if further)laboratory or field-testing will be required. After reviewing technical information documented in the PAR, government representatives, technical representatives from the affected facilities, and other stakeholders involved in the process will select the list of viable alternative coatings for consideration and testing under the project's Joint Test Protocol entitled Joint Test Protocol for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes and Field Test Plan entitled Field Evaluations Test Plan for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, both prepared by ITB. Test results will be reported in a Joint Test Report upon completion oftesting. The selection rationale and conclusions are documented in this PAR. A cost benefit analysis will be prepared to quantify the estimated capital and process costs of coating alternatives and cost savings relative to the current coating processes, however, some initial cost data has been included in this PAR. For this coatings project, isocyanates, as found in aliphatic isocyanate polyurethanes, were identified as the target HazMat to be eliminated. Table 1-1 lists the target HazMats, the related process and application, current specifications, and affected programs.

Sandia Review of High Bridge Associates Report: Comparison of Plutonium Disposition Alternatives: WIPP Diluted Plutonium Storage and MOX Fuel Irradiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shoemaker, Paul E.; Hardin, Ernest; Park, HeeHo Daniel

The subject report from High Bridge Associates (HBA) was issued on March 2, 2016, in reaction to a U.S. Department of Energy (DOE) program decision to pursue down-blending of surplus Pu and geologic disposal at the Waste Isolation Pilot Plant (WIPP). Sandia National Laboratories was requested by the DOE to review the technical arguments presented in the HBA report. Specifically, this review is organized around three technical topics: criticality safety, radiological release limits, and thermal impacts. Questions raised by the report pertaining to legal and regulatory requirements, safeguards and security, international agreements, and costing of alternatives, are beyond the scopemore » of this review.« less

Alternatives for Jet Engine Control. Volume 1: Modelling and Control Design with Jet Engine Data

NASA Technical Reports Server (NTRS)

Sain, M. K.

1985-01-01

This document compiles a comprehensive list of publications supported by, or related to, National Aeronautics and Space Administration Grant NSG-3048, entitled "Alternatives for Jet Engine Control". Dr. Kurt Seldner was the original Technical Officer for the grant, at Lewis Research Center. Dr. Bruce Lehtinen was the final Technical Officer. At the University of Notre Dame, Drs. Michael K. Sain and R. Jeffrey Leake were the original Project Directors, with Dr. Sain becoming the final Project Director. Publications cover work over a ten-year period. The Final Report is divided into two parts. Volume i, "Modelling and Control Design with Jet Engine Data", follows in this report. Volume 2, "Modelling and Control Design with Tensors", has been bound separately.

Optimized technical and scientific design approach for high performance anticoincidence shields

NASA Astrophysics Data System (ADS)

Graue, Roland; Stuffler, Timo; Monzani, Franco; Bastia, Paolo; Gryksa, Werner; Pahl, Germit

2018-04-01

This paper, "Optimized technical and scientific design approach for high performance anticoincidence shields," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.

Great Lakes transport of western coal: economic and technical analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elste, V.H.; Scher, R.M

1978-04-01

A comprehensive investigation of coal transportation from western mines via railroad unit trains plus water transport on the Great Lakes covers in detail: the design of coal colliers for the Great Lakes as limited in size by the Poe lock at Sault Ste. Marie or by river destinations; effects of ice freezing on the lakes or on the coal cargo; problems of designing for alternative transport of taconite pellets; the economic effects of variations in ship characteristics; the effect of fuel price and of operation through the winter; economic comparison of transport alternatives for various pairs of sources and destinations;more » the advantage (vs. a slurry pipeline) of being able to expand on a unit-by-unit basis; and that the rail-water route is lowest in cost for all destinations on the Great Lakes east of Detroit, but direct unit-train service to Chicago is either equal or superior to the rail-water combination. (''A unitrain operating on level track is a most energy-efficient producer of transportation and only an extremely large vessel can approach or equal this performance'').« less

Study on integration potential of gas turbines and gas engines into parabolic trough power plants

NASA Astrophysics Data System (ADS)

Vogel, Tobias; Oeljeklaus, Gerd; Görner, Klaus

2017-06-01

Hybrid power plants represent an important intermediate step on the way to an energy supply structure based substantially on renewable energies. Natural gas is the preferred fossil fuel for hybridization of solar thermal power plants, due to its low specific CO2-emission and technical advantages by means of integration into the power plant process. The power plant SHAMS ONE serves as an exemplary object of this study. In order to facilitate peaker gas turbines in an economical way to a combined cycle approach, with the SGT-400 an industrial gas turbine of the 10-20 MWel class have been integrated into the base case power plant. The concept has been set up, to make use of the gas turbine waste heat for power generation and increasing the overall power plant efficiency of the hybrid power plant at the same time. This concept represents an alternative to the widely used concept of combined cycle power plants with solar heat integration. Supplementary, this paper also dedicates the alternative to use gas engines instead of gas turbines.

Endovascular Management of Thoracic Aortic Aneurysms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fattori, Rossella, E-mail: rossella.fattori@unibo.it; Russo, Vincenzo; Lovato, Luigi

The overall survival of patients with thoracic aortic aneurysm (TAA) has improved significantly in the past few years. Endovascular treatment, proposed as an alternative to surgery, has been considered a therapeutic innovation because of its low degree of invasiveness, which allows the treatment of even high-surgical risk patients with limited complications and mortality. A major limitation is the lack of adequate evidence regarding long-term benefit and durability because follow-up has been limited to just a few years even in the largest series. The combination of endovascular exclusion with visceral branch revascularization for the treatment of thoraco-abdominal aortic aneurysms involving themore » visceral aorta has also been attempted. As an alternative, endografts with branches represent a technological evolution that allows treatment of complex anatomy. Even if only small numbers of patients and short follow-up are available, this technical approach, which has with limited mortality (<10%) and paraplegia rates, to expand endovascular treatment to TAA seems feasible. With improved capability to recognize proper anatomy and select clinical candidates, the choice of endovascular stent-graft placement may offer a strategy to optimize management and improve prognosis.« less

Alternative-fueled truck demonstration natural gas program: Caterpillar G3406LE development and demonstration

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

In 1990, the California Energy Commission, the South Coast Air Quality Management District, and the Southern California Gas Company joined together to sponsor the development and demonstration of compressed natural gas engines for Class 8 heavy-duty line-haul trucking applications. This program became part of an overall Alternative-Fueled Truck Demonstration Program, with the goal of advancing the technological development of alternative-fueled engines. The demonstration showed natural gas to be a technically viable fuel for Class 8 truck engines.

10 CFR 51.103 - Record of decision-general.

Code of Federal Regulations, 2010 CFR

2010-01-01

... preferences among alternatives based on relevant factors, including economic and technical considerations where appropriate, the NRC's statutory mission, and any essential considerations of national policy...

Native ureteropyelostomy in the treatment of obstructive uropathy in adult renal transplant. Experience and technical alternatives.

PubMed

Trilla, E; Lorente, D; Salvador, C; Planas, J; Placer, J; Celma, A; Cantarell, C; Moreso, F; Seron, D; Morote, J

2014-10-01

To analyze and evaluate our experience in surgical treatment with the open approach of the complex ureteral stenosis after adult kidney transplantation in a tertiary level hospital in the last seven years. We have reviewed the different surgical options used. A total of 589 consecutive adult renal transplants were performed from January 2005 to December 2012. Of these, 1.1% showed some degree of symptomatic obstructive uropathy which after initial urinary diversion required open surgical approach using the ipsilateral or contralateral native urinary tract. Characteristics of the patient, clinical examinations performed and surgical technique performed as well as their results are presented. During the period under review, in 5 men and 2 women who had ureteral stenoses after renal transplant, 7 reparative surgeries were performed by open ureteropyelostomy, using ipsilateral native ureter in 6 cases and contralateral ureter in the remaining case. In one case, uretero-calicial anastomosis was performed due to severe pyelic shrinkage. There were no significant complications. Native kidney nephrectomy was not required for further complications. All the patients operated on had optimum plasma creatinine levels with resolution of previous dilatation. The initial percutaneous nephrostomy followed by open surgical repair using native ureter represents a definitive, valid and optimal alternative in terms of safety and preservation of renal function. Copyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kovoor-Misra, S.

Technical organizations are not only vulnerable to crises, but have the potential to create catastrophic crises. This has been devastatingly illustrated by recent crises, such as the gas leak in Bhopal, India, the Exxon Valdez oil spill, and the Challenger explosion. Thus, crises preparation for these organizations. This paper describes a Multidimensional Approach to crisis preparation for technical organizations. As part of this approach, come critical factors for crisis preparation are also described. The Multidimensional Approach is derived from the literature and a study of the crisis preparation of nine technical organizations. 28 refs., 3 figs., 4 tab.

DE-FOA-EE0005502 Advanced Percussive Drilling Technology for Geothermal Exploration and Development Phase II Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Jiann-Cherng; Raymond, David W.; Prasad, Somuri V.

Percussive hammers are a promising advance in drilling technology for geothermal since they rely upon rock reduction mechanisms that are well-suited for use in the hard, brittle rock characteristic of geothermal formations. The project research approach and work plan includes a critical path to development of a high-temperature (HT) percussive hammer using a two- phase approach. The work completed in Phase I of the project demonstrated the viability of percussive hammers and that solutions to technical challenges in design, material technology, and performance are likely to be resolved. Work completed in Phase II focused on testing the findings from Phasemore » I and evaluating performance of the materials and designs at high- operating temperatures. A high-operating temperature (HOT) drilling facility was designed, built, and used to test the performance of the DTH under extreme conditions. Results from the testing indicate that a high-temperature capable hammer can be developed and is a viable alternative for user in the driller's toolbox.« less

Advanced Percussive Drilling Technology for Geothermal Exploration and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Jiann; Raymond, David; Prasad, Somuri

Percussive hammers are a promising advance in drilling technology for geothermal since they rely upon rock reduction mechanisms that are well-suited for use in the hard, brittle rock characteristic of geothermal formations. The project research approach and work plan includes a critical path to development of a high-temperature (HT) percussive hammer using a two phase approach. The work completed in Phase I of the project demonstrated the viability of percussive hammers and that solutions to technical challenges in design, material technology, and performance are likely to be resolved. Work completed in Phase II focused on testing the findings from Phasemore » I and evaluating performance of the materials and designs at high operating temperatures. A high-operating temperature (HOT) drilling facility was designed, built, and used to test the performance of the DTH under extreme conditions. Results from the testing indicate that a high-temperature capable hammer can be developed and is a viable alternative for use in the driller’s toolbox.« less

An interactive governance and fish chain approach to fisheries rebuilding: a case study of the Northern Gulf cod in eastern Canada.

PubMed

Khan, Ahmed; Chuenpagdee, Ratana

2014-09-01

Rebuilding collapsed fisheries is a multifaceted problem, requiring a holistic governance approach rather than technical management fixes. Using the Northern Gulf cod case study in eastern Canada, we illustrate how a "fish chain" framework, drawn from the interactive governance perspective, is particularly helpful in analyzing rebuilding challenges. The analysis demonstrates that factors limiting rebuilding exist along the entire fish chain, i.e., the pre-harvest, harvest, and post-harvest stages. These challenges are embedded in both the ecological and social systems associated with the Northern Gulf cod fisheries, as well as in the governing systems. A comparative analysis of the pre- and post-collapse of the cod fisheries also reveals governance opportunities in rebuilding, which lie in policy interventions such as integrated and ecosystem-based management, livelihood transitional programs, and cross-scale institutional arrangements. Lessons from the Northern Gulf cod case study, especially the missed opportunities to explore alternative governing options during the transition, are valuable for rebuilding other collapsed fisheries.

Network-driven design principles for neuromorphic systems.

PubMed

Partzsch, Johannes; Schüffny, Rene

2015-01-01

Synaptic connectivity is typically the most resource-demanding part of neuromorphic systems. Commonly, the architecture of these systems is chosen mainly on technical considerations. As a consequence, the potential for optimization arising from the inherent constraints of connectivity models is left unused. In this article, we develop an alternative, network-driven approach to neuromorphic architecture design. We describe methods to analyse performance of existing neuromorphic architectures in emulating certain connectivity models. Furthermore, we show step-by-step how to derive a neuromorphic architecture from a given connectivity model. For this, we introduce a generalized description for architectures with a synapse matrix, which takes into account shared use of circuit components for reducing total silicon area. Architectures designed with this approach are fitted to a connectivity model, essentially adapting to its connection density. They are guaranteeing faithful reproduction of the model on chip, while requiring less total silicon area. In total, our methods allow designers to implement more area-efficient neuromorphic systems and verify usability of the connectivity resources in these systems.

Network-driven design principles for neuromorphic systems

PubMed Central

Partzsch, Johannes; Schüffny, Rene

2015-01-01

Synaptic connectivity is typically the most resource-demanding part of neuromorphic systems. Commonly, the architecture of these systems is chosen mainly on technical considerations. As a consequence, the potential for optimization arising from the inherent constraints of connectivity models is left unused. In this article, we develop an alternative, network-driven approach to neuromorphic architecture design. We describe methods to analyse performance of existing neuromorphic architectures in emulating certain connectivity models. Furthermore, we show step-by-step how to derive a neuromorphic architecture from a given connectivity model. For this, we introduce a generalized description for architectures with a synapse matrix, which takes into account shared use of circuit components for reducing total silicon area. Architectures designed with this approach are fitted to a connectivity model, essentially adapting to its connection density. They are guaranteeing faithful reproduction of the model on chip, while requiring less total silicon area. In total, our methods allow designers to implement more area-efficient neuromorphic systems and verify usability of the connectivity resources in these systems. PMID:26539079

Genetic resistance: tolerance to vector-borne diseases and the prospects and challenges of genomics.

PubMed

Bahbahani, H; Hanotte, O

2015-04-01

Vector-borne diseases in cattle and small ruminants (e.g. trypanosomosis, Rift Valley fever and East Coast fever) are associated with major economic losses in tropical countries, and particularly on the African continent. A variety of control strategies (e.g. management, vaccination and/or acaricide treatments) are used to minimise their negative impacts. These strategies are often associated with environmental, technical and/or economic drawbacks. However, several indigenous livestock populations have been reported to show a level of genetic tolerance or resistance to such disease challenges (e.g. trypanotolerant N'Dama cattle and Djallonké sheep). Use of these populations represents a sustainable alternative approach to minimising the negative impact of such infection/infestation on livestock production. This review summarises the current understanding of the genetic control of these adaptations, identifies knowledge gaps and critically examines the possible impacts of genomics approaches to the genetic improvement of tolerance and/or resistance to vector-borne diseases.

Replacement model of city bus: A dynamic programming approach

NASA Astrophysics Data System (ADS)

Arifin, Dadang; Yusuf, Edhi

2017-06-01

This paper aims to develop a replacement model of city bus vehicles operated in Bandung City. This study is driven from real cases encountered by the Damri Company in the efforts to improve services to the public. The replacement model propounds two policy alternatives: First, to maintain or keep the vehicles, and second is to replace them with new ones taking into account operating costs, revenue, salvage value, and acquisition cost of a new vehicle. A deterministic dynamic programming approach is used to solve the model. The optimization process was heuristically executed using empirical data of Perum Damri. The output of the model is to determine the replacement schedule and the best policy if the vehicle has passed the economic life. Based on the results, the technical life of the bus is approximately 20 years old, while the economic life is an average of 9 (nine) years. It means that after the bus is operated for 9 (nine) years, managers should consider the policy of rejuvenation.

Mixed waste management options

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owens, C.B.; Kirner, N.P.

1991-12-31

Disposal fees for mixed waste at proposed commercial disposal sites have been estimated to be $15,000 to $40,000 per cubit foot. If such high disposal fees are imposed, generators may be willing to apply extraordinary treatment or regulatory approaches to properly dispose of their mixed waste. This paper explores the feasibility of several waste management scenarios and attempts to answer the question: Can mixed waste be managed out of existence? Existing data on commercially generated mixed waste streams are used to identify the realm of mixed waste known to be generated. Each waste stream is evaluated from both a regulatorymore » and technical perspective in order to convert the waste into a strictly low-level radioactive or a hazardous waste. Alternative regulatory approaches evaluated in this paper include a delisting petition, no migration petition, and a treatability variance. For each waste stream, potentially available treatment options are identified that could lead to these variances. Waste minimization methodology and storage for decay are also considered. Economic feasibility of each option is discussed broadly.« less

Shoreside Alternative Energy Evaluation

DTIC Science & Technology

2002-09-01

U.S. Coast Guard Research and Development Center 1082 Shennecossett Road, Groton, CT 06340-6096 Report No. CG-D-02-02 SHORESIDE ALTERNATIVE ENERGY...standard, specification, or regulation. Marc B. Mandler, Ph.D. Technical Director United States Coast Guard Research & Development Center 1082 ...Coast Guard Research and Development Center 1082 Shennecossett Road Groton, CT 06340-6096 10. Work Unit No. (TRAIS) 11. Contract or Grant No. 12

Data summary of municipal solid waste management alternatives. Volume 4, Appendix B: RDF technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1992-10-01

This appendix contains background information, technical descriptions, economic data, mass and energy balances, and information on environmental releases for the refuse derived fuels (RDF) option in municipal solid waste management alternatives. Demonstration programs at St. Louis, Missouri; Franklin, Ohio; and Delaware are discussed. Information on pellet production and cofiring with coal is also presented.

Participation and Performance Reporting for the Alternate Assessment Based on Modified Achievement Standards (AA-MAS). Technical Report 58

ERIC Educational Resources Information Center

Albus, Deb; Thurlow, Martha L.; Lazarus, Sheryl S.

2011-01-01

This report examines publicly reported participation and performance data for the alternate assessment based on modified achievement standards (AA-MAS). The authors' analysis of these data included all states publicly reporting AA-MAS data, regardless of whether they had received approval to use the results for Title I accountability calculations.…

10 CFR 504.7 - Prohibition against excessive use of petroleum or natural gas in mixtures-electing powerplants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Prohibition against excessive use of petroleum or natural...) ALTERNATE FUELS EXISTING POWERPLANTS § 504.7 Prohibition against excessive use of petroleum or natural gas... technically and financially feasible for a unit to use a mixture of petroleum or natural gas and an alternate...

NASA Collaborative Approach Mitigates Environmentally-Driven Obsolescence

NASA Technical Reports Server (NTRS)

Greene, Brian; Leeney, Bob; Richards, Joni

2016-01-01

National Aeronautics and Space Administration (NASA) missions, like Department of Defense (DoD) organizations, require the rigorous testing and qualification of critical materials. Obsolescence supply risks created by environmental requirements can affect the cost, schedule and performance of NASA missions and the resilience of critical infrastructure. The NASA Technology Evaluation for Environmental Risk Mitigation (TEERM) Principal Center helps to identify obsolescence supply risks driven by environmental requirements and works proactively with NASA Centers and Programs, the DoD, the European Space Agency (ESA) and other agencies and partners to identify and evaluate environmentally friendly alternatives. TEERM tracks environmental regulations, identifies the potential loss of material availability and works with NASA programs and Centers to evaluate potential impacts through a risk assessment approach. TEERM collaborative projects identify, demonstrate and evaluate commercially viable alternative technologies and materials. A major focus during the Space Shuttle Program was the need to replace ozone depleting substances that were used in spray foam and cleaning applications. The potential obsolescence of coatings containing hexavalent chromium and the risks associated with lead free solder were also of concern for the Space Shuttle and present ongoing risks to new programs such as the Space Launch System. One current project teams NASA and ESA in the evaluation and testing of individual coatings and coating systems as replacements for hexavalent chromium coatings in aerospace applications. The proactive, collaborative approach used by TEERM helps reduce the cost burden on any one team partner, reduces duplication of effort, and enhances the technical quality and overall applicability of the testing and analysis.

Comparison of Customer Preference for Bulk Material Handling Equipment through Fuzzy-AHP Approach

NASA Astrophysics Data System (ADS)

Sen, Kingshuk; Ghosh, Surojit; Sarkar, Bijan

2017-06-01

In the present study, customer's perception has played one of the important roles for selection of the exact equipment out of available alternatives. The present study is dealt with the method of optimization of selection criteria of a material handling equipment, based on the technical specifications considered to be available at the user end. In this work, the needs of customers have been identified and prioritized, that lead to the selection of number of criteria, which have direct effect upon the performance of the equipment. To check the consistency of selection criteria, first of all an AHP based methodology is adopted with the identified criteria and available product categories, based upon which, the judgments of the users are defined to derive the priority scales. Such judgments expressed the relative strength or intensity of the impact of the elements of the hierarchy. Subsequently, all the alternatives have ranked for each identified criteria with subsequent constitution of weighted matrices. The same has been compared with the normalized values of approximate selling prices of the equipments to determine individual cost-benefit ratio. Based on the cost-benefit ratio, the equipment is ranked. With same conditions, the study is obtained again with a Fuzzy AHP concept, where a fuzzy linguistic approach has reduced the amount of uncertainty in decision making, caused by conventional AHP due to lack of deterministic approach. The priority vectors of category and criteria are determined separately and multiplied to obtain composite score. Subsequently, the average of fuzzy weights was determined and the preferences of equipment are ranked.

An Alternative to EPA Method 9 -- Field Validation of the Digital Opacity Compliance System (DOCS)

DTIC Science & Technology

2005-03-15

at the completion of the Phase I and Phase II DOCS field demonstration. These included the following 1) anemometer, 2) sling psychrometer , 3) Abney...anemometer (Eastern Technical Associates, Inc.) Sky conditions Visual observation Relative Humidity Sling Psychrometer (Eastern Technical Associates...least have access to a range of climatic monitoring equipment including the following 1) anemometer, 2) sling psychrometer , 3) Abney Level (sun angle

Documentation of the runqual module for ADDAMS: Comparison of predicted runoff water quality with standards. Environmental effects of dredging. Technical notes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schroeder, P.R.; Gibson, A.C.; Dardeau, E.A.

This technical note has a twofold purpose: to describe a technique for comparing the predicted quality of surface runoff from confined dredged material disposal areas with applicable water quality standards and to document a computer program called RUNQUAL, written for that purpose as a part of the Automated Dredging and Disposal Alternatives Management System (ADDAMS).

Technical Assessment of Maglev System Concepts

DTIC Science & Technology

1998-10-01

pressurizes the loop but retains sufficient heat capacity for the day’s cooling needs. Magneplane uses a cryorefrigerator to keep its supercritical helium in...comparative baselines. the technical and economic viability of maglev in * Apply this process to alternative U.S. maglev the U.S. and to recommend...output/joules- heat the same data as in Figure 119 with the aforemen- input). In effect, applying this factor implies that tioned efficiencies applied

The Archimedes satellite system

NASA Astrophysics Data System (ADS)

Taylor, Stuart C.; Shurvinton, William D.

1992-03-01

Archimedes is a satellite system conceived by the European Space Agency (ESA) to effectively serve the European market for Mobile Radio Services (MRS). This paper describes the requirements and technical design of the Archimedes satellite system. The underlying assumptions and trade-offs behind the design are detailed and the design is compared and contrasted against alternative design solutions, both technically and economically. A path forward for the development of the system is indicated.

Alternative Feedstocks Program Technical and Economic Assessment: Thermal/Chemical and Bioprocessing Components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bozell, J. J.; Landucci, R.

This resource document on biomass to chemicals opportunities describes the development of a technical and market rationale for incorporating renewable feedstocks into the chemical industry in both a qualitative and quantitative sense. The term "renewable feedstock?s" can be defined to include a huge number of materials such as agricultural crops rich in starch, lignocellulosic materials (biomass), or biomass material recovered from a variety of processing wastes.

Developmental problems and their solution for the Space Shuttle main engine alternate liquid oxygen high-pressure turbopump: Anomaly or failure investigation the key

NASA Astrophysics Data System (ADS)

Ryan, R.; Gross, L. A.

1995-05-01

The Space Shuttle main engine (SSME) alternate high-pressure liquid oxygen pump experienced synchronous vibration and ball bearing life problems that were program threatening. The success of the program hinged on the ability to solve these development problems. The design and solutions to these problems are engirded in the lessons learned and experiences from prior programs, technology programs, and the ability to properly conduct failure or anomaly investigations. The failure investigation determines the problem cause and is the basis for recommending design solutions. For a complex problem, a comprehensive solution requires that formal investigation procedures be used, including fault trees, resolution logic, and action items worked through a concurrent engineering-multidiscipline team. The normal tendency to use an intuitive, cut-and-try approach will usually prove to be costly, both in money and time and will reach a less than optimum, poorly understood answer. The SSME alternate high-pressure oxidizer turbopump development has had two complex problems critical to program success: (1) high synchronous vibrations and (2) excessive ball bearing wear. This paper will use these two problems as examples of this formal failure investigation approach. The results of the team's investigation provides insight into the complexity of the turbomachinery technical discipline interacting/sensitivities and the fine balance of competing investigations required to solve problems and guarantee program success. It is very important to the solution process that maximum use be made of the resources that both the contractor and Government can bring to the problem in a supporting and noncompeting way. There is no place for the not-invented-here attitude. The resources include, but are not limited to: (1) specially skilled professionals; (2) supporting technologies; (3) computational codes and capabilities; and (4) test and manufacturing facilities.

Developmental problems and their solution for the Space Shuttle main engine alternate liquid oxygen high-pressure turbopump: Anomaly or failure investigation the key

NASA Technical Reports Server (NTRS)

Ryan, R.; Gross, L. A.

1995-01-01

The Space Shuttle main engine (SSME) alternate high-pressure liquid oxygen pump experienced synchronous vibration and ball bearing life problems that were program threatening. The success of the program hinged on the ability to solve these development problems. The design and solutions to these problems are engirded in the lessons learned and experiences from prior programs, technology programs, and the ability to properly conduct failure or anomaly investigations. The failure investigation determines the problem cause and is the basis for recommending design solutions. For a complex problem, a comprehensive solution requires that formal investigation procedures be used, including fault trees, resolution logic, and action items worked through a concurrent engineering-multidiscipline team. The normal tendency to use an intuitive, cut-and-try approach will usually prove to be costly, both in money and time and will reach a less than optimum, poorly understood answer. The SSME alternate high-pressure oxidizer turbopump development has had two complex problems critical to program success: (1) high synchronous vibrations and (2) excessive ball bearing wear. This paper will use these two problems as examples of this formal failure investigation approach. The results of the team's investigation provides insight into the complexity of the turbomachinery technical discipline interacting/sensitivities and the fine balance of competing investigations required to solve problems and guarantee program success. It is very important to the solution process that maximum use be made of the resources that both the contractor and Government can bring to the problem in a supporting and noncompeting way. There is no place for the not-invented-here attitude. The resources include, but are not limited to: (1) specially skilled professionals; (2) supporting technologies; (3) computational codes and capabilities; and (4) test and manufacturing facilities.

Multimodal audio guide for museums and exhibitions

NASA Astrophysics Data System (ADS)

Gebbensleben, Sandra; Dittmann, Jana; Vielhauer, Claus

2006-02-01

In our paper we introduce a new Audio Guide concept for exploring buildings, realms and exhibitions. Actual proposed solutions work in most cases with pre-defined devices, which users have to buy or borrow. These systems often go along with complex technical installations and require a great degree of user training for device handling. Furthermore, the activation of audio commentary related to the exhibition objects is typically based on additional components like infrared, radio frequency or GPS technology. Beside the necessity of installation of specific devices for user location, these approaches often only support automatic activation with no or limited user interaction. Therefore, elaboration of alternative concepts appears worthwhile. Motivated by these aspects, we introduce a new concept based on usage of the visitor's own mobile smart phone. The advantages in our approach are twofold: firstly the Audio Guide can be used in various places without any purchase and extensive installation of additional components in or around the exhibition object. Secondly, the visitors can experience the exhibition on individual tours only by uploading the Audio Guide at a single point of entry, the Audio Guide Service Counter, and keeping it on her or his personal device. Furthermore, since the user usually is quite familiar with the interface of her or his phone and can thus interact with the application device easily. Our technical concept makes use of two general ideas for location detection and activation. Firstly, we suggest an enhanced interactive number based activation by exploiting the visual capabilities of modern smart phones and secondly we outline an active digital audio watermarking approach, where information about objects are transmitted via an analog audio channel.

Different surgical strategies in the treatment of familial adenomatous polyposis: what's the role of the ileal pouch-anal anastomosis?

PubMed

Leonard, D; Wolthuis, A; D'Hoore, A; Bruyninx, L; Van De Stadt, J; Van Cutsem, E; Kartheuser, A

2011-09-01

Restorative coloproctectomy (RCP) with ileal pouch-anal anastomosis (IPAA), is one of the surgical responses to the crucial question of prophylactic treatment in familial adenomatous polyposis (FAP). No consensus has been reached, until now, to choose between IPAA and ileo-rectal anastomosis (IRA), the rectal sparing prophylactic colectomy. This paper aims to review the latest issues related to IPAA and highlights its specificities compared to IRA. PubMed database was searched using the following search items: familial adenomatous polyposis, surgery, ileal pouch-anal anastomosis, ileo-rectal anastomosis. Papers published between 1978 and 2010 were selected. Absence of mortality, acceptable morbidity and good functional results combined to high quality of life have promoted the IPAA technique. New technical issues such as the double stapled technique, mesenteric lengthening, omission of temporary protective stoma can be addressed almost systematically for these patients. A laparoscopic approach, lessening the body image impact, has proven to be as effective and safe as the open approach to perform IPAA. Further advantages of laparoscopic IPAA rely on the lower adhesion formation resulting in less small bowel occlusion. Sexuality, fertility and childbirth are important functional issues often cited as threatened by the pelvic manoeuvres of the IPAA technique which can be prevented by close rectal wall dissection and a laparoscopic approach. IPAA offers the best available prophylaxis in FAP patients. Technical enhancements in IPAA will most probably decrease the functional risks. Thus IPAA remains the alternative to IRA for the prophylactic treatment of FAP.Nevertheless, based on the latest evidence, the choice between both procedures is still matter of debate.

Assessment of Alternative Conceptual Models Using Reactive Transport Modeling with Monitoring Data

NASA Astrophysics Data System (ADS)

Dai, Z.; Price, V.; Heffner, D.; Hodges, R.; Temples, T.; Nicholson, T.

2005-12-01

Monitoring data proved very useful in evaluating alternative conceptual models, simulating contaminant transport behavior, and reducing uncertainty. A graded approach using three alternative conceptual site models was formulated to simulate a field case of tetrachloroethene (PCE) transport and biodegradation. These models ranged from simple to complex in their representation of subsurface heterogeneities. The simplest model was a single-layer homogeneous aquifer that employed an analytical reactive transport code, BIOCHLOR (Aziz et al., 1999). Due to over-simplification of the aquifer structure, this simulation could not reproduce the monitoring data. The second model consisted of a multi-layer conceptual model, in combination with numerical modules, MODFLOW and RT3D within GMS, to simulate flow and reactive transport. Although the simulation results from the second model were comparatively better than those from the simple model, they still did not adequately reproduce the monitoring well concentrations because the geological structures were still inadequately defined. Finally, a more realistic conceptual model was formulated that incorporated heterogeneities and geologic structures identified from well logs and seismic survey data using the Petra and PetraSeis software. This conceptual model included both a major channel and a younger channel that were detected in the PCE source area. In this model, these channels control the local ground-water flow direction and provide a preferential chemical transport pathway. Simulation results using this conceptual site model proved compatible with the monitoring concentration data. This study demonstrates that the bias and uncertainty from inadequate conceptual models are much larger than those introduced from an inadequate choice of model parameter values (Neuman and Wierenga, 2003; Meyer et al., 2004; Ye et al., 2004). This case study integrated conceptual and numerical models, based on interpreted local hydrogeologic and geochemical data, with detailed monitoring plume data. It provided key insights for confirming alternative conceptual site models and assessing the performance of monitoring networks. A monitoring strategy based on this graded approach for assessing alternative conceptual models can provide the technical bases for identifying critical monitoring locations, adequate monitoring frequency, and performance indicator parameters for performance monitoring involving ground-water levels and PCE concentrations.

Conceptualizing the Organizational Role of Technical Communicators: A Systems Approach.

ERIC Educational Resources Information Center

Harrison, Teresa M.; Debs, Mary Beth

1988-01-01

Uses a systems approach to organizational theory to argue that technical communicators function as "boundary spanners," who make sense of and disseminate information required for coordination between organizational groups, and for effective responses to the environment. (JAD)

Using causal maps to support ex-post assessment of social impacts of dams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aledo, Antonio, E-mail: Antonio.Aledo@ua.es; García-Andreu, Hugo, E-mail: Hugo.Andreu@ua.es; Pinese, José, E-mail: pinese@uel.br

- Highlights: • We defend the usefulness of causal maps (CM) for ex-post impact assessment of dams. • Political decisions are presented as unavoidable technical measures. • CM enable the identification of multiple causes involved in the dam impacts. • An alternative management of the dams is shown from the precise tracking of the causes. • Participatory CM better the quality of information and the governance of the research. This paper presents the results of an ex-post assessment of two important dams in Brazil. The study follows the principles of Social Impact Management, which offer a suitable framework for analyzingmore » the complex social transformations triggered by hydroelectric dams. In the implementation of this approach, participative causal maps were used to identify the ex-post social impacts of the Porto Primavera and Rosana dams on the community of Porto Rico, located along the High Paraná River. We found that in the operation of dams there are intermediate causes of a political nature, stemming from decisions based on values and interests not determined by neutral, exclusively technical reasons; and this insight opens up an area of action for managing the negative impacts of dams.« less

Community Engagement Compared With Technical Assistance to Disseminate Depression Care Among Low-Income, Minority Women: A Randomized Controlled Effectiveness Study

PubMed Central

Sherbourne, Cathy; Chung, Bowen; Tang, Lingqi; Wright, Aziza L.; Whittington, Yolanda; Wells, Kenneth; Miranda, Jeanne

2016-01-01

Objectives. To compare the effectiveness of a (CEP) versus a technical assistance approach (Resources for Services, or RS) to disseminate depression care for low-income ethnic minority women. Methods. We conducted secondary analyses of intervention effects for largely low-income, minority women subsample (n = 595; 45.1% Latino and 45.4% African American) in a matched, clustered, randomized control trial conducted in 2 low-resource communities in Los Angeles, California, between 2010 and 2012. Outcomes assessed included mental health, socioeconomic factors, and service use at 6- and 12-month follow-up. Results. Although we found no intervention difference for depressive symptoms, there were statistically significant effects for mental health quality of life, resiliency, homelessness risk, and financial difficulties at 6 months, as well as missed work days, self-efficacy, and care barriers at 12 months favoring CEP relative to RS. CEP increased use of outpatient substance abuse services and faith-based depression visits at 6 months. Conclusions. Engaging health care and social community programs may offer modest improvements on key functional and socioeconomic outcomes, reduce care barriers, and increase engagement in alternative depression services for low-income, predominantly ethnic minority women. PMID:27552274

Biogenic and Synthetic Peptides with Oppositely Charged Amino Acids as Binding Sites for Mineralization.

PubMed

Lemloh, Marie-Louise; Altintoprak, Klara; Wege, Christina; Weiss, Ingrid M; Rothenstein, Dirk

2017-01-28

Proteins regulate diverse biological processes by the specific interaction with, e.g., nucleic acids, proteins and inorganic molecules. The generation of inorganic hybrid materials, such as shell formation in mollusks, is a protein-controlled mineralization process. Moreover, inorganic-binding peptides are attractive for the bioinspired mineralization of non-natural inorganic functional materials for technical applications. However, it is still challenging to identify mineral-binding peptide motifs from biological systems as well as for technical systems. Here, three complementary approaches were combined to analyze protein motifs consisting of alternating positively and negatively charged amino acids: (i) the screening of natural biomineralization proteins; (ii) the selection of inorganic-binding peptides derived from phage display; and (iii) the mineralization of tobacco mosaic virus (TMV)-based templates. A respective peptide motif displayed on the TMV surface had a major impact on the SiO₂ mineralization. In addition, similar motifs were found in zinc oxide- and zirconia-binding peptides indicating a general binding feature. The comparative analysis presented here raises new questions regarding whether or not there is a common design principle based on acidic and basic amino acids for peptides interacting with minerals.

Alternative Fuels Data Center

Science.gov Websites

Pollution Prevention Grants Program The Pollution Prevention (P2) Grants Program supports state and tribal technical assistance, education, and research programs that help businesses and industries

Application of ultrasonic sensor for measuring distances in robotics

NASA Astrophysics Data System (ADS)

Zhmud, V. A.; Kondratiev, N. O.; Kuznetsov, K. A.; Trubin, V. G.; Dimitrov, L. V.

2018-05-01

Ultrasonic sensors allow us to equip robots with a means of perceiving surrounding objects, an alternative to technical vision. Humanoid robots, like robots of other types, are, first, equipped with sensory systems similar to the senses of a human. However, this approach is not enough. All possible types and kinds of sensors should be used, including those that are similar to those of other animals and creations (in particular, echolocation in dolphins and bats), as well as sensors that have no analogues in the wild. This paper discusses the main issues that arise when working with the HC-SR04 ultrasound rangefinder based on the STM32VLDISCOVERY evaluation board. The characteristics of similar modules for comparison are given. A subroutine for working with the sensor is given.

Using archetypes for defining CDA templates.

PubMed

Moner, David; Moreno, Alberto; Maldonado, José A; Robles, Montserrat; Parra, Carlos

2012-01-01

While HL7 CDA is a widely adopted standard for the documentation of clinical information, the archetype approach proposed by CEN/ISO 13606 and openEHR is gaining recognition as a means of describing domain models and medical knowledge. This paper describes our efforts in combining both standards. Using archetypes as an alternative for defining CDA templates permit new possibilities all based on the formal nature of archetypes and their ability to merge into the same artifact medical knowledge and technical requirements for semantic interoperability of electronic health records. We describe the process followed for the normalization of existing legacy data in a hospital environment, from the importation of the HL7 CDA model into an archetype editor, the definition of CDA archetypes and the application of those archetypes to obtain normalized CDA data instances.

She Wears the Pants: The Reform Dress as Technology in Nineteenth-Century America.

PubMed

Mas, Catherine

This article examines the American dress-reform movement, detailing the ways in which reformers conceptualized clothing as a social and bodily technology. In the mid-nineteenth century, women began making and wearing the "reform dress"-a costume consisting of pants and shortened, lightweight skirts-as an alternative to burdensome feminine fashions. When ridiculed in public for wearing overtly masculine garments, dress reformers insisted their clothing was healthful, functional, and natural. This article discusses women's use of medical science and technical knowledge in their rejection of fashion, promotion of sexual equality, and efforts to change mainstream clothing practices. When approached from a technological perspective, the reform dress reveals broader tensions in an industrializing American society, such as changing gender relations and new understandings of the relationship between humans and technology.

Distributional Cost-Effectiveness Analysis

PubMed Central

Asaria, Miqdad; Griffin, Susan; Cookson, Richard

2015-01-01

Distributional cost-effectiveness analysis (DCEA) is a framework for incorporating health inequality concerns into the economic evaluation of health sector interventions. In this tutorial, we describe the technical details of how to conduct DCEA, using an illustrative example comparing alternative ways of implementing the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP). The 2 key stages in DCEA are 1) modeling social distributions of health associated with different interventions, and 2) evaluating social distributions of health with respect to the dual objectives of improving total population health and reducing unfair health inequality. As well as describing the technical methods used, we also identify the data requirements and the social value judgments that have to be made. Finally, we demonstrate the use of sensitivity analyses to explore the impacts of alternative modeling assumptions and social value judgments. PMID:25908564

Getting Personal: Individuality, Innovation, and Technical Communication.

ERIC Educational Resources Information Center

Steiner, Carol J.

1999-01-01

Suggests that effective communication between technical and nontechnical people is difficult because technical communication lacks a personal dimension: technical people give up their identity to be considered competent. Argues that a different approach to communication education for scientists, engineers, and technologists is required to equip…

Theoretical Aspects of the Patterns Recognition Statistical Theory Used for Developing the Diagnosis Algorithms for Complicated Technical Systems

NASA Astrophysics Data System (ADS)

Obozov, A. A.; Serpik, I. N.; Mihalchenko, G. S.; Fedyaeva, G. A.

2017-01-01

In the article, the problem of application of the pattern recognition (a relatively young area of engineering cybernetics) for analysis of complicated technical systems is examined. It is shown that the application of a statistical approach for hard distinguishable situations could be the most effective. The different recognition algorithms are based on Bayes approach, which estimates posteriori probabilities of a certain event and an assumed error. Application of the statistical approach to pattern recognition is possible for solving the problem of technical diagnosis complicated systems and particularly big powered marine diesel engines.

A Megawatt Power Module for Ship Service - Supplement. Volume 1: Program Technical Report

DTIC Science & Technology

2007-06-01

Alternator” otherwise known as an “AC Homopolar ” or “Synchronous Homopolar ” machine for this application. The various motor /generator machine...After reviewing alternative motor /generator technologies as discussed above, a Homopolar Inductor Alternator (HIA) was selected for the technology...integrated flywheel energy storage system with homopolar inductor motor /generator and high-frequency drive”, Industry Applications, IEEE Transactions on

[Team training and assessment in mixed reality-based simulated operating room : Current state of research in the field of simulation in spine surgery exemplified by the ATMEOS project].

PubMed

Stefan, P; Pfandler, M; Wucherer, P; Habert, S; Fürmetz, J; Weidert, S; Euler, E; Eck, U; Lazarovici, M; Weigl, M; Navab, N

2018-04-01

Surgical simulators are being increasingly used as an attractive alternative to clinical training in addition to conventional animal models and human specimens. Typically, surgical simulation technology is designed for the purpose of teaching technical surgical skills (so-called task trainers). Simulator training in surgery is therefore in general limited to the individual training of the surgeon and disregards the participation of the rest of the surgical team. The objective of the project Assessment and Training of Medical Experts based on Objective Standards (ATMEOS) is to develop an immersive simulated operating room environment that enables the training and assessment of multidisciplinary surgical teams under various conditions. Using a mixed reality approach, a synthetic patient model, real surgical instruments and radiation-free virtual X‑ray imaging are combined into a simulation of spinal surgery. In previous research studies, the concept was evaluated in terms of realism, plausibility and immersiveness. In the current research, assessment measurements for technical and non-technical skills are developed and evaluated. The aim is to observe multidisciplinary surgical teams in the simulated operating room during minimally invasive spinal surgery and objectively assess the performance of the individual team members and the entire team. Moreover, the effectiveness of training methods and surgical techniques or success critical factors, e. g. management of crisis situations, can be captured and objectively assessed in the controlled environment.

The Future of the Space Age or how to Evaluate Innovative Ideas

NASA Astrophysics Data System (ADS)

Vollerthun, A.; Fricke, E.

2002-05-01

Based on an initiative of the German Aerospace Industry Association to foster a more transparent and structured funding of German commercial-oriented space projects a three-phased approach is suggested in this paper, to stepwise improve and evaluate proposed concepts for space-related innovations. The objective of this concept was to develop a transparent, structured, and reproducible process to select the right innovative project in terms of political, economical, and technical objectives for funding by e.g. a governmental agency. A stepwise process and related methods, that cover technical as well as economical aspects (and related sensitivities) are proposed. Based on the special needs and requirements of space industry the proposals are compared to a set of predefined top level objectives/requirements. Using an initial trades analysis with the criteria company, technology, product, and market, an initial business case is analyzed. The alternative innovative concepts are in the third process step subject to a very detailed analysis. The full economical and technical scale of the projects is evaluated and metrics for e.g. the 'Return on Investment' or 'Break Even Point' are determined, to compare the various innovations. Risks related to time, cost, and quality are considered, when performing sensitivity analysis by varying the most important factors of the project. Before discussing critical aspects of the proposed process, space-related examples will be presented to show how the process could be applied, and how different concepts should be evaluated.

Alternative Fuels Data Center

Science.gov Websites

of the following measures: Payment of incentives to customers that install EVSE; Time-of-use rates customers; and Technical assistance programs for government fleets and private organizations. Utilities may

Installation Restoration Program Stage 3. Remedial Investigation/ Feasibility Study Elmendorf AFB, Alaska. Volume 2. Section 5 - Bibliography Text

DTIC Science & Technology

1990-05-01

ELME’IDORF AFB, AK UNITED STATES AIR FORCE OCCUPATIONAL & ENVIRONMENTAL HEALTH LABORATORY (AFSC) ilb(. IiCAL Sr.(VICES DIVISION (AFOEHLi £3) I BROOKS AIR...UNITED STATES AIR FORCE OCCUPATIONAL AND ENVIRONMENTAL HEALTH LABORATORY (AFSC) TECHNICAL SERVICES DIVISION (AFOEHL/TS) BROOKS AIR FORCE BASE, TEXAS...the following criteria: technical feasibility, institutional requirements, environmental impacts, public health impacts, and cost. This Alternative

The composing process in technical communication

NASA Technical Reports Server (NTRS)

Masse, R. E.

1981-01-01

The theory and application of the composing process in technical communications is addressed. The composing process of engineers, some implications for composing research for the teaching and research of technical communication, and an interpretation of the processes as creative experience are also discussed. Two areas of technical communications summarized concern: the rhetorical features of technical communications, and the theoretical background for a process-based view, a problem-solving approach to technical writing.

Alternative Techniques for Treatment of Complex Below-the Knee Arterial Occlusions in Diabetic Patients With Critical Limb Ischemia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gandini, Roberto; Uccioli, Luigi; Spinelli, Alessio

The purpose of this study was to describe alternative endovascular (EV) techniques and assess their feasibility and efficacy in minimizing failure rates in limb salvage for the treatment of complex below-the knee (BTK) occlusions that could not be crossed with a conventional antegrade access. Between December 2007 and November 2010, 1,035 patients (557 male) underwent EV treatment for critical limb ischemia in our institution. In 124 (12% [83 male], mean age 68.2 {+-} 0.5 years) patients, transfemoral antegrade revascularization attempt failed, and an alternative approach was used. Follow-up was performed at 1 and 6 months. Results were compared with 56more » patients treated between November 2002 and November 2007, in whom conventional technique was unsuccessful and unconventional techniques were not adopted. Technical success was achieved in 119 (96%) patients. The limb-salvage rates were 96.8% and 83% at 1- and 6-month follow-up, respectively. Sixteen (12.9%) and 33 (26.6%) patients underwent reintervention at 1- and 6-month follow-up, respectively. Transcutaneous oxygen tension increased at 1 month (44.7 {+-} 1.1 vs. 15.7 {+-} 0.8 mmHg; p < 0.001) and remained stable at follow-up. Twenty (16.1%) patients required major amputation. Thirteen (10.4%) patients died during follow-up. In our previous experience, percutaneous transluminal angioplasty failure, amputation, and death rates were 10.9, 39.2, and 23.2%, respectively. Alternative techniques allowed a significant decrease of major amputation and death rates (p = 0.0001 and p = 0.02, respectively). The use of alternative techniques seems feasible in case of a failed antegrade BTK revascularization attempt and could minimize failure rates in the treatment of complex occlusions while providing satisfying clinical success rates at 6 months.« less

[Alternative approaches in thyroid surgery].

PubMed

Maurer, E; Wächter, S; Bartsch, D K

2017-08-01

In thyroid surgery multiple different cervical minimally invasive (partly endoscopically assisted) and extracervical endoscopic (partly robot-assisted) approaches have been developed in the last 20 years. The aim of all these alternative approaches to the thyroid gland is optimization of the cosmetic result. The indications for the use of alternative and conventional approaches are principally the same. Important requirements for the use of alternative methods are nevertheless a broad experience in conventional thyroid operations of the thyroid and adequate patient selection under consideration of the size of the thyroid and the underlying pathology. Contraindications for the use of alternative approaches are a large size of the thyroid gland including local symptoms, advanced carcinomas, reoperations and previous radiations of the anterior neck. The current article gives an overview of the clinically implemented alternative approaches for thyroid surgery. Of those the majority must still be considered as experimental. The alternative approaches to the thyroid gland can be divided in cervical minimally invasive, extracervical endosopic (robot-assisted) and transoral operations (natural orifice transluminal endoscopic surgery, NOTES). Since conventional thyroid operations are standardized procedures with low complication rates, alternative approaches to the thyroid gland are considered critically in Germany. The request for a perfect cosmetic result should not overweigh patients' safety. Only a few alternative approaches (e. g. MIVAT, RAT) can yet be considered as a safe addition in experienced hands in highly selected patients.

High Energy Astronomy Observatory, Mission C, Phase A. Volume 3: Appendices

NASA Technical Reports Server (NTRS)

1972-01-01

Technical data, and experiment and spacecraft alternatives are presented in support of the HEAO-C, whose primary objective is a detailed study of the more interesting high energy sources, using grazing incidence X-ray telescopes and a spacecraft pointing accuracy of + or - 1 arc minute. The analyses presented cover the mission analysis and launch vehicle; thermal control trade studies and supporting analyses; attitude sensing and control analyses; electrical systems; and reliability analysis. The alternate experiments which were considered are listed, and the advantages and disadvantages of several alternate observatory configurations are assessed.

A method for building evaluation competency among community-based organizations.

PubMed

Kelly, Cheryl M; LaRose, Jessi; Scharff, Darcell P

2014-05-01

Community-based organizations often lack the capacity (e.g., time, staff, skills) to effectively evaluate programs, policies, and environmental changes. Providing evaluation technical assistance and training can be an effective and feasible way to build individual evaluation competency. The purpose of this article is to present a practical approach and related tools that can be used by evaluators and others (e.g., academic partners, funders) providing assistance to build evaluation skills in community organizations. The approach described was developed in collaboration with local universities and a regional health foundation to provide intensive technical support to 19 community-based organizations awarded funding to implement obesity prevention projects. Technical assistance processes and tools were designed to be tailored to organizations' capacity and needs and can be used as templates by others who provide technical assistance. Evaluators, funders, and academic partners can use lessons learned from this experience to help shape and implement evaluation technical assistance approaches with community-based organizations.

The U.S. Gas Flooding Experience: CO2 Injection Strategies and Impact on Ultimate Recovery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nunez-Lopez, Vanessa; Hosseini, Seyyed; Gil-Egui, Ramon

The Permian Basin in West Texas and southwestern New Mexico has seen 45 years of oil reserve growth through CO2 enhanced oil recovery (CO2 EOR). More than 60 CO2 EOR projects are currently active in the region’s limestone, sandstone and dolomite reservoirs. Water alternating gas (WAG) has been the development strategy of choice in the Permian for several technical and economic reasons. More recently, the technology started to get implemented in the much more porous and permeable clastic depositional systems of the onshore U.S. Gulf Coast. Continued CO2 injection (CGI), as opposed to WAG, was selected as the injection strategymore » to develop Gulf Coast oil fields, where CO2 injection volumes are significantly larger (up to 6 times larger) than those of the Permian. We conducted a compositional simulation based study with the objective of comparing the CO2 utilization ratios (volume of CO2 injected to produce a barrel of oil) of 4 conventional and novel CO2 injection strategies: (1) continuous gas injection (CGI), (2) water alternating gas (WAG), (3) water curtain injection (WCI), and (4) WAG and WCI combination. These injection scenarios were simulated using the GEM module from the Computer Modeling Group (CMG). GEM is an advanced general equation-of-state compositional simulator, which includes equation of state, CO2 miscible flood, CO2/brine interactions, and complex phase behavior. The simulator is set up to model three fluid phases including water, oil, and gas. Our study demonstrates how the selected field development strategy has a significant impact on the ultimate recovery of CO2-EOR projects, with GCI injection providing maximum oil recovery in absolute volume terms, but with WAG offering a more balanced technical-economical approach.« less

Futuragua: Fostering Cross-Scale Knowledge to Inform Social-Environmental Decision Processes for Building Drought Resilience in Highly Seasonal Environments

NASA Astrophysics Data System (ADS)

McDaniels, T.; Steyn, D. G.; Johnson, M. S.; Small, M.; Leclerc, G.; Vignola, R.; Chan, K.; Grossmann, I.; Wong-Parodi, G.

2014-12-01

Improving resilience to drought in complex social-environmental systems (SES) is extraordinarily important, particularly for rural tropical locations where small changes in climate regimes can have dramatic SES impacts. Efforts to build drought resilience must necessarily be planned and implemented within SES governance systems that involve linkages in water and land use administration from local to national levels. These efforts require knowledge and understanding that links climate and weather forecasts to regional and local hydrology, to social-economic and environmental systems, and to governance processes. In order to provide structure for such complex choices and investments, we argue that a focus on structured decision processes that involve linkages among science, technological perspectives, and public values conducted with agencies and stakeholders will provide a crucial framework for comparing and building insight for pursuing alternative courses of action to build drought resilience. This paper focuses on a regional case study in the seasonally-dry northwest region of Costa Rica, in watersheds rated as most threatened in the country in terms of drought. We present the overall framework guiding the transdisciplinary efforts to link scientific and technical understanding to public values, in order to foster civil society actions that lead to improved drought resilience. Initial efforts to characterize hydrological and climate regimes will be reported along with our approach to linking natural science findings, social inventories in terms of perspectives on SES, and the psychology and patterns of reliance on forecast information that provide the basis for characterizing public understanding. The overall linkage of technical and value information is focused on creating and comparing alternative actions that can potentially build resilience in short and long time frames by building decision making processes involving stakeholders, agencies and interested parties.

MACRA, Alternative Payment Models, and the Physician-Focused Payment Model: Implications for Radiology.

PubMed

Rosenkrantz, Andrew B; Nicola, Gregory N; Allen, Bibb; Hughes, Danny R; Hirsch, Joshua A

2017-06-01

The Medicare Access and CHIP Reauthorization Act (MACRA) of 2015 describes alternative payment models (APMs) as new approaches to health care payment that incentivize higher quality and value. MACRA incentivizes increasing APM participation by all physician specialties over the coming years. Some APMs will be deemed Advanced APMs; clinicians who are a Qualifying Participant in an Advanced APM will receive substantial benefits under MACRA including an automatic 5% payment bonus, regardless of their performance and savings within the APM, and a larger payment rate increase beginning in 2026. Existing APMs are most relevant to primary care physicians, and opportunities for radiologists to participate in Advanced APMs fulfilling Qualified Participant requirements are limited. Physician-Focused Payment Models (PFPMs), as described in MACRA, are APMs that target physicians' Medicare payments based on quality and cost of physician services. PFPMs must address a new issue or specialty compared with existing APMs and will thus foster a more diverse range of APMs encompassing a wider range of specialties. The PFPM Technical Advisory Committee is a new independent agency that will review proposals for new PFPMs and provide recommendations to CMS regarding their approval. The PFPM Technical Advisory Committee comprises largely primary care physicians and health policy experts and is not required to consult clinical experts when reviewing new specialist-proposed PFPMs. As PFPMs provide a compelling opportunity for radiologists to demonstrate and be rewarded for their unique contributions toward patient care, radiologists should embrace this new model and actively partner with other stakeholders in developing radiology-relevant PFPMs. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons.

PubMed

Eid, Lara; Lachance, Mathieu; Hickson, Gilles; Rossignol, Elsa

2018-04-20

GABAergic interneurons (INs) are critical components of neuronal networks that drive cognition and behavior. INs destined to populate the cortex migrate tangentially from their place of origin in the ventral telencephalon (including from the medial and caudal ganglionic eminences (MGE, CGE)) to the dorsal cortical plate in response to a variety of intrinsic and extrinsic cues. Different methodologies have been developed over the years to genetically manipulate specific pathways and investigate how they regulate the dynamic cytoskeletal changes required for proper IN migration. In utero electroporation has been extensively used to study the effect of gene repression or overexpression in specific IN subtypes while assessing the impact on morphology and final position. However, while this approach is readily used to modify radially migrating pyramidal cells, it is more technically challenging when targeting INs. In utero electroporation generates a low yield given the decreased survival rates of pups when electroporation is conducted before e14.5, as is customary when studying MGE-derived INs. In an alternative approach, MGE explants provide easy access to the MGE and facilitate the imaging of genetically modified INs. However, in these explants, INs migrate into an artificial matrix, devoid of endogenous guidance cues and thalamic inputs. This prompted us to optimize a method where INs can migrate in a more naturalistic environment, while circumventing the technical challenges of in utero approaches. In this paper, we describe the combination of ex utero electroporation of embryonic mouse brains followed by organotypic slice cultures to readily track, image and reconstruct genetically modified INs migrating along their natural paths in response to endogenous cues. This approach allows for both the quantification of the dynamic aspects of IN migration with time-lapse confocal imaging, as well as the detailed analysis of various morphological parameters using neuronal reconstructions on fixed immunolabeled tissue.

Design and impact assessment of watershed investments: An approach based on ecosystem services and boundary work

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adem Esmail, Blal, E-mail: blal.ademesmail@unitn.it; Geneletti, Davide

Watershed investments, whose main aim is to secure water for cities, represent a promising opportunity for large-scale sustainability transitions in the near future. If properly designed, they promote activities in the watershed that enhance ecosystem services while protecting nature and biodiversity, as well as achieving other societal goals. In this paper, we build on the concepts of ecosystem services and boundary work, to develop and test an operative approach for designing and assessing the impact of watershed investments. The approach is structured to facilitate negotiations among stakeholders. Its strategic component includes setting the agenda; defining investment scenarios; and assessing themore » performance of watershed investments as well as planning for a follow-up. Its technical component concerns data processing; tailoring spatially explicit ecosystem service models; hence their application to design a set of “investment portfolios”, generate future land use scenarios, and model impacts on selected ecosystem services. A case study illustrates how the technical component can be developed in a data scarce context in sub-Saharan Africa in a way that is functional to support the steps of the strategic component. The case study addresses soil erosion and water scarcity-related challenges affecting Asmara, a medium-sized city in Eritrea, and considers urban water security and rural poverty alleviation as two illustrative objectives, within a ten-year planning horizon. The case study results consist in spatially explicit data (investment portfolio, land use scenario, impact on ecosystem services), which were aggregated to quantitatively assess the performance of different watershed investments scenarios, in terms of changes in soil erosion control. By addressing stakeholders' concerns of credibility, saliency, and legitimacy, the approach is expected to facilitate negotiation of objectives, definition of scenarios, and assessment of alternative watershed investments, ultimately, to contribute to implementing an adaptive watershed management.« less

Ecotoxicological risk assessment linked to infilling quarries with treated dredged seaport sediments.

PubMed

Perrodin, Yves; Donguy, Gilles; Bazin, Christine; Volatier, Laurence; Durrieu, Claude; Bony, Sylvie; Devaux, Alain; Abdelghafour, Mohammed; Moretto, Robert

2012-08-01

The dredged sediments of polluted seaports now raise complex management problems since it is no longer possible to discharge them into the sea. This results in the need to manage them on land, raising other types of technical, economic and environmental problems. Regarding the technical and economic dimensions, traditional waste treatment methods have proved to be poorly adapted, due to very high costs and low absorbable volumes. In this context, filling quarries in coastal areas with treated sediments could represent an interesting alternative for these materials. Nevertheless, for the environmental dimension, it is necessary to demonstrate that this possibility is harmless to inland ecosystems. Consequently, a specific ecotoxicological risk assessment methodology has been formulated and tested on three sediments taken from seaboards of France, in view to providing an operational and usable tool for the prior validation of any operation to fill quarries with treated seaport sediments. This method incorporates the formulation of a global conceptual model of the scenario studied and the definition of protocols for each of its steps: the characterisation of exposures (based on a simulation of sediment deposit), the characterisation of effects (via the study of sediments ecotoxicity), and the final ecotoxicological risk assessment performed as a calculation of a risk quotient. It includes the implementation in parallel of two types of complementary approach: the "substances" approach derived from the European methodology for assessing new substances placed on the market, and the "matrix" approach which is similar to methods developed in France to assess ecological risks in other domains (waste management, polluted site management, …). The application of this dual approach to the three sediments tested led to conclude with reliability that the project to deposit sediments "1" and "2" presented a low risk for the peripheral aquatic ecosystems while sediment "3" presented a high risk. Copyright © 2012 Elsevier B.V. All rights reserved.

An approach to knowledge structuring for advanced phases of the Technical and Management Information System (TMIS)

NASA Technical Reports Server (NTRS)

Goranson, H. T.

1986-01-01

The Technical and Management Information System (TMIS) must employ on enlightened approach to its object structure, but basic issues in conceptual structuring remain to be resolved. Sirius outlines the necessary agenda and reports on progress toward solutions.

A History of the ARPANET: The First Decade

DTIC Science & Technology

1981-04-01

10 2.2 Major Technical Problems and Approaches 11-12 2.3 Major Changes in Objectives and Approaches 11-19 3, ,3 Scientific and Technical Results and...successful projects ever undertaken by DARPA! The program has initiated extensive changes in the Defense Department’s use of computers as well as in...the ARPANET project represents a similarly far-reaching change in the use of computers by mankind. The full impact of the technical changes set in

Alternate Approaches to Exploration: The Single Crew Module Concept

NASA Technical Reports Server (NTRS)

Chambliss, Joe

2011-01-01

The Cx Program envisioned exploration of the moon and mars using an extrapolation of the Apollo approach. If new technology development initiatives are successful, they will provide capabilities that can enable alternate approaches. This presentation will provide a brief overview of the Cx approaches for lunar and Mars missions and some of the alternatives that were considered. Then an alternative approach referred to as a Single Crew Module approach is described. The SCM concept employs new technologies in a way that could reduce exploration cost and possibly schedule. Options to the approaches will be presented and discussed.

Comparing multi-criteria decision analysis and integrated assessment to support long-term water supply planning

PubMed Central

Maurer, Max; Lienert, Judit

2017-01-01

We compare the use of multi-criteria decision analysis (MCDA)–or more precisely, models used in multi-attribute value theory (MAVT)–to integrated assessment (IA) models for supporting long-term water supply planning in a small town case study in Switzerland. They are used to evaluate thirteen system scale water supply alternatives in four future scenarios regarding forty-four objectives, covering technical, social, environmental, and economic aspects. The alternatives encompass both conventional and unconventional solutions and differ regarding technical, spatial and organizational characteristics. This paper focuses on the impact assessment and final evaluation step of the structured MCDA decision support process. We analyze the performance of the alternatives for ten stakeholders. We demonstrate the implications of model assumptions by comparing two IA and three MAVT evaluation model layouts of different complexity. For this comparison, we focus on the validity (ranking stability), desirability (value), and distinguishability (value range) of the alternatives given the five model layouts. These layouts exclude or include stakeholder preferences and uncertainties. Even though all five led us to identify the same best alternatives, they did not produce identical rankings. We found that the MAVT-type models provide higher distinguishability and a more robust basis for discussion than the IA-type models. The needed complexity of the model, however, should be determined based on the intended use of the model within the decision support process. The best-performing alternatives had consistently strong performance for all stakeholders and future scenarios, whereas the current water supply system was outperformed in all evaluation layouts. The best-performing alternatives comprise proactive pipe rehabilitation, adapted firefighting provisions, and decentralized water storage and/or treatment. We present recommendations for possible ways of improving water supply planning in the case study and beyond. PMID:28481881

Risk-Informed Decision Making: Application to Technology Development Alternative Selection

NASA Technical Reports Server (NTRS)

Dezfuli, Homayoon; Maggio, Gaspare; Everett, Christopher

2010-01-01

NASA NPR 8000.4A, Agency Risk Management Procedural Requirements, defines risk management in terms of two complementary processes: Risk-informed Decision Making (RIDM) and Continuous Risk Management (CRM). The RIDM process is used to inform decision making by emphasizing proper use of risk analysis to make decisions that impact all mission execution domains (e.g., safety, technical, cost, and schedule) for program/projects and mission support organizations. The RIDM process supports the selection of an alternative prior to program commitment. The CRM process is used to manage risk associated with the implementation of the selected alternative. The two processes work together to foster proactive risk management at NASA. The Office of Safety and Mission Assurance at NASA Headquarters has developed a technical handbook to provide guidance for implementing the RIDM process in the context of NASA risk management and systems engineering. This paper summarizes the key concepts and procedures of the RIDM process as presented in the handbook, and also illustrates how the RIDM process can be applied to the selection of technology investments as NASA's new technology development programs are initiated.

The socio-technical organisation of community pharmacies as a factor in the Electronic Prescription Service Release Two implementation: a qualitative study

PubMed Central

2012-01-01

Background The introduction of a new method of transmitting prescriptions from general practices to community pharmacies in England (Electronic Prescription Service Release 2 (EPS2)) has generated debate on how it will change work practice. As EPS2 will be a key technical element in dispensing, we reviewed the literature to find that there were no studies on how social and technical elements come together to form work practice in community pharmacies. This means the debate has little point of reference. Our aim therefore was to study the ways social and technical elements of a community pharmacy are used to achieve dispensing through the development of a conceptual model on pharmacy work practice, and to consider how a core technical element such the EPS2 could change work practice. Method We used ethnographic methods inclusive of case-study observations and interviews to collect qualitative data from 15 community pharmacies that were in the process of adopting or were soon to adopt EPS2. We analysed the case studies thematically and used rigorous multi-dimensional and multi-disciplinary interpretive validation techniques to cross analyse findings. Results In practice, dispensing procedures were not designed to take into account variations in human and technical integration, and assumed that repetitive and collective use of socio-technical elements were at a constant. Variables such as availability of social and technical resources, and technical know-how of staff were not taken into account in formalised procedures. Yet community pharmacies were found to adapt their dispensing in relation to the balance of social and technical elements available, and how much of the social and technical elements they were willing to integrate into dispensing. While some integrated as few technical elements as possible, some depended entirely on technical artefacts. This pattern also applied to the social elements of dispensing. Through the conceptual model development process, we identified three approaches community pharmacies used to appropriate procedures in practice. These were ‘technically oriented’, ‘improvising’ or ‘socially oriented’. Conclusion We offer a model of different work approaches community pharmacies use to dispense, which suggests that when adopting a core technical element such as the EPS2 system of dispensing there could be variations in its successful adoption. Technically oriented pharmacies might find it easiest to integrate a similar artefact into work practice although needs EPS2 to synchronise effectively with existing technologies. Pharmacies adopting an improvising-approach have the potential to improve how they organise dispensing through EPS2 although they will need to improve how they apply their operating procedures. Socially oriented pharmacies will need to dramatically adapt their approach to dispensing since they usually rely on few technical tools. PMID:23256484

The socio-technical organisation of community pharmacies as a factor in the Electronic Prescription Service Release Two implementation: a qualitative study.

PubMed

Harvey, Jasmine; Avery, Anthony J; Waring, Justin; Barber, Nick

2012-12-20

The introduction of a new method of transmitting prescriptions from general practices to community pharmacies in England (Electronic Prescription Service Release 2 (EPS2)) has generated debate on how it will change work practice. As EPS2 will be a key technical element in dispensing, we reviewed the literature to find that there were no studies on how social and technical elements come together to form work practice in community pharmacies. This means the debate has little point of reference. Our aim therefore was to study the ways social and technical elements of a community pharmacy are used to achieve dispensing through the development of a conceptual model on pharmacy work practice, and to consider how a core technical element such the EPS2 could change work practice. We used ethnographic methods inclusive of case-study observations and interviews to collect qualitative data from 15 community pharmacies that were in the process of adopting or were soon to adopt EPS2. We analysed the case studies thematically and used rigorous multi-dimensional and multi-disciplinary interpretive validation techniques to cross analyse findings. In practice, dispensing procedures were not designed to take into account variations in human and technical integration, and assumed that repetitive and collective use of socio-technical elements were at a constant. Variables such as availability of social and technical resources, and technical know-how of staff were not taken into account in formalised procedures. Yet community pharmacies were found to adapt their dispensing in relation to the balance of social and technical elements available, and how much of the social and technical elements they were willing to integrate into dispensing. While some integrated as few technical elements as possible, some depended entirely on technical artefacts. This pattern also applied to the social elements of dispensing. Through the conceptual model development process, we identified three approaches community pharmacies used to appropriate procedures in practice. These were 'technically oriented', 'improvising' or 'socially oriented'. We offer a model of different work approaches community pharmacies use to dispense, which suggests that when adopting a core technical element such as the EPS2 system of dispensing there could be variations in its successful adoption. Technically oriented pharmacies might find it easiest to integrate a similar artefact into work practice although needs EPS2 to synchronise effectively with existing technologies. Pharmacies adopting an improvising-approach have the potential to improve how they organise dispensing through EPS2 although they will need to improve how they apply their operating procedures. Socially oriented pharmacies will need to dramatically adapt their approach to dispensing since they usually rely on few technical tools.

Outcomes of Percutaneous Coronary Interventions for Chronic Total Occlusion Performed by Highly Experienced Japanese Specialists: The First Report From the Japanese CTO-PCI Expert Registry.

PubMed

Suzuki, Yoriyasu; Tsuchikane, Etsuo; Katoh, Osamu; Muramatsu, Toshiya; Muto, Makoto; Kishi, Koichi; Hamazaki, Yuji; Oikawa, Yuji; Kawasaki, Tomohiro; Okamura, Atsunori

2017-11-13

This report describes the registry and presents an initial analysis of outcomes for the different PCI approaches taken by the specialists. Strategies for percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) are complex. The Japanese Board of CTO Interventional Specialists has developed a prospective, nonrandomized registry of patients undergoing CTO-PCIs performed by 41 highly experienced Japanese specialists. Over the study period of January 2014 to December 2015, the registry included 2,846 consecutive CTO-PCI cases undertaken in Japan. The authors compared clinical outcomes between the different PCI approaches, following the intention-to-treat principle. The overall technical success rate of the procedures was 89.9%. The specialists frequently chose a retrograde approach as the primary CTO-PCI strategy (in 27.8% of cases). The technical success rate of the primary antegrade approach was significantly better than that of the primary retrograde approach (91.0% vs. 87.3%; p < 0.0001). The technical success rate decreased to 78.0% with the rescue retrograde approach. Parallel guidewire crossing and intravascular ultrasound-guided wire crossing were performed after guidewire escalation during antegrade CTO-PCI with a high technical success rate (75.0% to 88.9%). Severe lesion calcification was a strong predictor of failed CTO-PCI. CTO-PCI performed by highly experienced specialists achieved a high technical success rate. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Efficiency of Health Care Production in Low-Resource Settings: A Monte-Carlo Simulation to Compare the Performance of Data Envelopment Analysis, Stochastic Distance Functions, and an Ensemble Model

PubMed Central

Giorgio, Laura Di; Flaxman, Abraham D.; Moses, Mark W.; Fullman, Nancy; Hanlon, Michael; Conner, Ruben O.; Wollum, Alexandra; Murray, Christopher J. L.

2016-01-01

Low-resource countries can greatly benefit from even small increases in efficiency of health service provision, supporting a strong case to measure and pursue efficiency improvement in low- and middle-income countries (LMICs). However, the knowledge base concerning efficiency measurement remains scarce for these contexts. This study shows that current estimation approaches may not be well suited to measure technical efficiency in LMICs and offers an alternative approach for efficiency measurement in these settings. We developed a simulation environment which reproduces the characteristics of health service production in LMICs, and evaluated the performance of Data Envelopment Analysis (DEA) and Stochastic Distance Function (SDF) for assessing efficiency. We found that an ensemble approach (ENS) combining efficiency estimates from a restricted version of DEA (rDEA) and restricted SDF (rSDF) is the preferable method across a range of scenarios. This is the first study to analyze efficiency measurement in a simulation setting for LMICs. Our findings aim to heighten the validity and reliability of efficiency analyses in LMICs, and thus inform policy dialogues about improving the efficiency of health service production in these settings. PMID:26812685

A New Sacroiliac Joint Injection Technique and Its Short-Term Effect on Chronic Sacroiliac Region Pain.

PubMed

Do, Kyung Hee; Ahn, Sang Ho; Jones, Rodney; Jang, Sung Ho; Son, Su Min; Lee, Dong Gyu; Cho, Hee Kyung; Choi, Gyu Sik; Cho, Yun-Woo

2016-10-01

Sacroiliac joint (SIJ) injections have been used to provide short-term relief of SIJ pain. In this study, the authors investigated a new technique using a superior approach. Twenty four patients with chronic SI joint paint were recruited. Each patient was treated with a single SIJ intra-articular injection plus a periarticular injection of local anesthetic and corticosteroid in one procedure. Technical accuracy of the intra-articular procedure was determined by having 2 independent observers review and rate the quality of arthrograms obtained. Treatment effects were evaluated using a numerical rating scale, the Oswestry disability index (ODI) and global perceived effect (GPE). Both independent observers agreed that satisfactory arthrograms were obtained in all patients. Pain scores and disability were significantly reduced at 2 weeks and 4 weeks after treatment. Nineteen patients (79%) reported satisfaction with treatment. No serious adverse effects were encountered. The superior approach consistently achieves good access to the SI joint, and achieves outcomes that are compatible with those of other techniques. The superior approach constitutes an alternative to other techniques for injections into the SI joint. © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Machine Learning Algorithms for prediction of regions of high Reynolds Averaged Navier Stokes Uncertainty

NASA Astrophysics Data System (ADS)

Mishra, Aashwin; Iaccarino, Gianluca

2017-11-01

In spite of their deficiencies, RANS models represent the workhorse for industrial investigations into turbulent flows. In this context, it is essential to provide diagnostic measures to assess the quality of RANS predictions. To this end, the primary step is to identify feature importances amongst massive sets of potentially descriptive and discriminative flow features. This aids the physical interpretability of the resultant discrepancy model and its extensibility to similar problems. Recent investigations have utilized approaches such as Random Forests, Support Vector Machines and the Least Absolute Shrinkage and Selection Operator for feature selection. With examples, we exhibit how such methods may not be suitable for turbulent flow datasets. The underlying rationale, such as the correlation bias and the required conditions for the success of penalized algorithms, are discussed with illustrative examples. Finally, we provide alternate approaches using convex combinations of regularized regression approaches and randomized sub-sampling in combination with feature selection algorithms, to infer model structure from data. This research was supported by the Defense Advanced Research Projects Agency under the Enabling Quantification of Uncertainty in Physical Systems (EQUiPS) project (technical monitor: Dr Fariba Fahroo).

Parallel computation with molecular-motor-propelled agents in nanofabricated networks.

PubMed

Nicolau, Dan V; Lard, Mercy; Korten, Till; van Delft, Falco C M J M; Persson, Malin; Bengtsson, Elina; Månsson, Alf; Diez, Stefan; Linke, Heiner; Nicolau, Dan V

2016-03-08

The combinatorial nature of many important mathematical problems, including nondeterministic-polynomial-time (NP)-complete problems, places a severe limitation on the problem size that can be solved with conventional, sequentially operating electronic computers. There have been significant efforts in conceiving parallel-computation approaches in the past, for example: DNA computation, quantum computation, and microfluidics-based computation. However, these approaches have not proven, so far, to be scalable and practical from a fabrication and operational perspective. Here, we report the foundations of an alternative parallel-computation system in which a given combinatorial problem is encoded into a graphical, modular network that is embedded in a nanofabricated planar device. Exploring the network in a parallel fashion using a large number of independent, molecular-motor-propelled agents then solves the mathematical problem. This approach uses orders of magnitude less energy than conventional computers, thus addressing issues related to power consumption and heat dissipation. We provide a proof-of-concept demonstration of such a device by solving, in a parallel fashion, the small instance {2, 5, 9} of the subset sum problem, which is a benchmark NP-complete problem. Finally, we discuss the technical advances necessary to make our system scalable with presently available technology.

An evaluation of some alternative approaches for reducing fan tone noise

NASA Astrophysics Data System (ADS)

Dittmar, James H.; Woodward, Richard P.

1992-02-01

The potential of two alternative approaches for reducing fan ton noise was investigated in this study. One of these approaches increases the number of rotor blades to shift the tone noise to higher frequencies that are not rated as strongly by the perceived noise scale. This alternative fan also would have a small number of long chord stator vanes which would reduce the stator response and lower rotor-stator interaction noise. Comparison of the conventional and alternative fan concepts showed that this alternative approach has as large or larger a perceived tone noise reduction potential as the conventional approach. The other alternative, a high Mach number inlet, is evaluated both for its noise attenuation and for its change in noise directivity.

Conventional vs Biomimetic Approaches to the Exploration of Mars

NASA Astrophysics Data System (ADS)

Ellery, A.

It is not usual to refer to convention in planetary exploration missions by virtue of the innovation required for such projects. The term conventional refers to the methodologies, tools and approaches typically adopted in engineering that are applied to such missions. Presented is a "conventional" Mars rover mission in which the author was involved - ExoMars - into which is interspersed references to examples where biomimetic approaches may yield superior capabilities. Biomimetics is a relatively recently active area of research which seeks to examine how biological systems solve the problem of survival in the natural environment. Biological organisms are autonomous entities that must survive in a hostile world adapting both adaptivity and robustness. It is not then surprising that biomimetics is particularly useful when applied to robotic elements of a Mars exploration mission. I present a number of areas in which biomimetics may yield new solutions to the problem of Mars exploration - optic flow navigation, potential field navigation, genetically-evolved neuro-controllers, legged locomotion, electric motors implementing muscular behaviour, and a biomimetic drill based on the wood wasp ovipositor. Each of these techniques offers an alternative approach to conventional ones. However, the perceptive hurdles are likely to dwarf the technical hurdles in implementing many of these methods in the near future.

Using Object-Oriented Databases for Implementation of Interactive Electronic Technical Manuals

DTIC Science & Technology

1992-03-01

analytical process applied throughout the system acquisition program in order to define supportability related design factors and to ensure development of a...Node Alternatives Node Alternatives (NODEALTS) is a list of mutually exclusive nodes, grouped together by the fact that they apply to different...contextual situations. The content specific layer NODEALTS element is a reference to a set of nodes that might apply in different situations. No hierarchy

A Technical Analysis Information Fusion Approach for Stock Price Analysis and Modeling

NASA Astrophysics Data System (ADS)

Lahmiri, Salim

In this paper, we address the problem of technical analysis information fusion in improving stock market index-level prediction. We present an approach for analyzing stock market price behavior based on different categories of technical analysis metrics and a multiple predictive system. Each category of technical analysis measures is used to characterize stock market price movements. The presented predictive system is based on an ensemble of neural networks (NN) coupled with particle swarm intelligence for parameter optimization where each single neural network is trained with a specific category of technical analysis measures. The experimental evaluation on three international stock market indices and three individual stocks show that the presented ensemble-based technical indicators fusion system significantly improves forecasting accuracy in comparison with single NN. Also, it outperforms the classical neural network trained with index-level lagged values and NN trained with stationary wavelet transform details and approximation coefficients. As a result, technical information fusion in NN ensemble architecture helps improving prediction accuracy.

40 CFR 1505.2 - Record of decision in cases requiring environmental impact statements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... alternatives based on relevant factors including economic and technical considerations and agency statutory missions. An agency shall identify and discuss all such factors including any essential considerations of...

CAPSULE REPORT: AQUEOUS MERCURY TREATMENT

EPA Science Inventory

This report describes established technologies and identifies evolving methods for treating aqueous mercury. The information provided encompasses full-, pilot- and bench-scale treatment results as presented in the technical literature. The report describes alternative technologi...

47 CFR 1.1314 - Environmental impact statements (EISs).

Code of Federal Regulations, 2014 CFR

2014-10-01

... law or which have relevant expertise. The Bureau may direct that technical studies be made by the... costs associated with the proposed action, as well as comparative analyses of alternatives. The Bureau...

47 CFR 1.1314 - Environmental impact statements (EISs).

Code of Federal Regulations, 2013 CFR

2013-10-01

... law or which have relevant expertise. The Bureau may direct that technical studies be made by the... costs associated with the proposed action, as well as comparative analyses of alternatives. The Bureau...

47 CFR 1.1314 - Environmental impact statements (EISs).

Code of Federal Regulations, 2011 CFR

2011-10-01

... relevant expertise. The Bureau may direct that technical studies be made by the applicant and that the... the proposed action, as well as comparative analyses of alternatives. The Bureau may also consult...

47 CFR 1.1314 - Environmental impact statements (EISs).

Code of Federal Regulations, 2010 CFR

2010-10-01

... relevant expertise. The Bureau may direct that technical studies be made by the applicant and that the... the proposed action, as well as comparative analyses of alternatives. The Bureau may also consult...

47 CFR 1.1314 - Environmental impact statements (EISs).

Code of Federal Regulations, 2012 CFR

2012-10-01

... law or which have relevant expertise. The Bureau may direct that technical studies be made by the... costs associated with the proposed action, as well as comparative analyses of alternatives. The Bureau...

47 CFR 68.614 - Oppositions and appeals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... exhausted, the aggrieved party shall file its opposition with the Commission for de novo review. (b) As an alternative, oppositions to proposed technical criteria may be filed directly with the Commission for de novo...

47 CFR 68.614 - Oppositions and appeals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... exhausted, the aggrieved party shall file its opposition with the Commission for de novo review. (b) As an alternative, oppositions to proposed technical criteria may be filed directly with the Commission for de novo...

48 CFR 227.7102-4 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... processes. (2) Use the clause at 252.227-7015 with its Alternate I in solicitations and contracts, including..., Validation of Restrictive Markings on Technical Data, in solicitations and contracts using FAR part 12...

48 CFR 227.7102-4 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... processes. (2) Use the clause at 252.227-7015 with its Alternate I in contracts for the development or..., Validation of Restrictive Markings on Technical Data, in all solicitations and contracts for commercial items...

48 CFR 227.7102-4 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... processes. (2) Use the clause at 252.227-7015 with its Alternate I in contracts for the development or..., Validation of Restrictive Markings on Technical Data, in all solicitations and contracts for commercial items...

48 CFR 227.7102-4 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... processes. (2) Use the clause at 252.227-7015 with its Alternate I in solicitations and contracts, including..., Validation of Restrictive Markings on Technical Data, in solicitations and contracts using FAR part 12...

Proceedings of the conference on alternative energy sources for Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rothman, I.N.

1981-01-01

Four primary areas of study for alternative energy sources for Texas are considered. These are: energy demand supply and economics; prospects for energy resources (oil, lignite, coal, nuclear, goethermal and solar) and conservation; financial and technical constraints; and future planning. The following papers are presented: US energy outlook to 1990; energy supply and demand projections; comparative economics of solar energy in the generation of big power; gas present and future prospects; prospects for enhanced recovery of oil in Texas; the outlook for coal in USA; implementation of nuclear power in Texas; future outlook - geopressured-geothermal energy for Texas; future prospectsmore » for conservation and solar energy; financing and money supply constraints; technical constraints to energy supply increase; planning for the future - the crisis that drones on. Two papers have been abstracted separately.« less

Technical Bases to Aid in the Decision of Conducting Full Power Ground Nuclear Tests for Space Fission Reactors

NASA Astrophysics Data System (ADS)

Hixson, Laurie L.; Houts, Michael G.; Clement, Steven D.

2004-02-01

The extent to which, if any, full power ground nuclear testing of space reactors should be performed has been a point of discussion within the industry for decades. Do the benefits outweigh the risks? Are there equivalent alternatives? Can a test facility be constructed (or modified) in a reasonable amount of time? Is the test article an accurate representation of the flight system? Are the costs too restrictive? The obvious benefits of full power ground nuclear testing; obtaining systems integrated reliability data on a full-scale, complete end-to-end system; come at some programmatic risk. Safety related information is not obtained from a full-power ground nuclear test. This paper will discuss and assess these and other technical considerations essential in the decision to conduct full power ground nuclear-or alternative-tests.

Cost/benefit tradeoffs for reducing the energy consumption of the commercial air transportation system. Volume 1: Technical analysis

NASA Technical Reports Server (NTRS)

Kraus, E. F.

1976-01-01

The effectiveness and associated costs of operational and technical options for reduced fuel consumption by Douglas aircraft in the domestic airline fleet are assessed. Areas explored include alternative procedures for airline and flight operations, advanced and state of the art technology, modification and derivative configurations, new near-term aircraft, turboprop configuration studies, and optimum aircraft geometry. Data for each aircraft studied is presented in tables and graphs.

The Training, Retention, and Assessment of Digital Skills: A Review and Integration of the Literature

DTIC Science & Technology

2006-11-01

Staff, G1 Authorized and approved for distribution: STANLEY M. HALPIN MICHELLE SAMS Acting Technical Director Acting Director Technical review by...research has found some benefit for spacing practice for motor skills. In an investigation of fuel and electrical repairers who were trained to test... electrical alternators using either massed or spaced training, the spaced training group made 40% fewer errors and took half the time to complete the tasks

Linking Gateway Technical College with Workforce Development: The SC Johnson-A Family Company Story.

ERIC Educational Resources Information Center

Knudson, Edward

2004-01-01

Seven years ago, SC Johnson--A Family Company approached Gateway Technical College with a need to further strengthen their incumbent workforce's technical training and education. Retirements, brain drain, and competition for technical expertise were the forces driving SC Johnson to develop a comprehensive, flexible, and timely workplace education…

The Roles of Technical Communication Researchers in Design Scholarship

ERIC Educational Resources Information Center

Sánchez, Fernando

2017-01-01

Design has come to be understood as an essential aspect of the work that technical communicators claim. As a result, research in the field of technical communication has approached studies of design in numerous ways. This article showcases how technical communication researchers assume the roles of observers, testers, critics, creators, and…

TECHNICAL APPROACHES TO CHARACTERIZING AND CLEANING UP BROWNFIELDS SITES: GUIDANCE DOCUMENT

EPA Science Inventory

NRMRL-CIN-1741 SAIC. Technical Approaches to Characterizing and Cleaning up Brownfields Sites. EPA/625/R/00/009 (NTIS PB2002-105021) , Available: 68-C7-0011. The guidance document gives assistance to communities, decision-makers, states and municipalities, academia, and the p...

Approaches to ICT-Enhanced Teaching in Technical and Vocational Education: A Phenomenographic Perspective

ERIC Educational Resources Information Center

Khan, Md. Shahadat Hossain; Markauskaite, Lina

2017-01-01

This paper presents the results of a study undertaken from a phenomenographic perspective, which examines teachers' approaches to information communication technology (ICT)-enhanced teaching in vocational tertiary education. Twenty-three teachers from three Australian Technical and Further Education (TAFE) institutions participated in…

Joint Common Architecture Demonstration (JCA Demo) Final Report

DTIC Science & Technology

2016-07-28

approach for implementing open systems [16], formerly known as the Modular Open Systems Approach (MOSA). OSA is a business and technical strategy to... TECHNICAL REPORT RDMR-AD-16-01 JOINT COMMON ARCHITECTURE DEMONSTRATION (JCA DEMO) FINAL REPORT Scott A. Wigginton... Modular Avionics .......................................................................... 5 E. Model-Based Engineering

A new generation of real-time DOS technology for mission-oriented system integration and operation

NASA Technical Reports Server (NTRS)

Jensen, E. Douglas

1988-01-01

Information is given on system integration and operation (SIO) requirements and a new generation of technical approaches for SIO. Real-time, distribution, survivability, and adaptability requirements and technical approaches are covered. An Alpha operating system program management overview is outlined.

Does integration of HIV and sexual and reproductive health services improve technical efficiency in Kenya and Swaziland? An application of a two-stage semi parametric approach incorporating quality measures

PubMed Central

Obure, Carol Dayo; Jacobs, Rowena; Guinness, Lorna; Mayhew, Susannah; Vassall, Anna

2016-01-01

Theoretically, integration of vertically organized services is seen as an important approach to improving the efficiency of health service delivery. However, there is a dearth of evidence on the effect of integration on the technical efficiency of health service delivery. Furthermore, where technical efficiency has been assessed, there have been few attempts to incorporate quality measures within efficiency measurement models particularly in sub-Saharan African settings. This paper investigates the technical efficiency and the determinants of technical efficiency of integrated HIV and sexual and reproductive health (SRH) services using data collected from 40 health facilities in Kenya and Swaziland for 2008/2009 and 2010/2011. Incorporating a measure of quality, we estimate the technical efficiency of health facilities and explore the effect of integration and other environmental factors on technical efficiency using a two-stage semi-parametric double bootstrap approach. The empirical results reveal a high degree of inefficiency in the health facilities studied. The mean bias corrected technical efficiency scores taking quality into consideration varied between 22% and 65% depending on the data envelopment analysis (DEA) model specification. The number of additional HIV services in the maternal and child health unit, public ownership and facility type, have a positive and significant effect on technical efficiency. However, number of additional HIV and STI services provided in the same clinical room, proportion of clinical staff to overall staff, proportion of HIV services provided, and rural location had a negative and significant effect on technical efficiency. The low estimates of technical efficiency and mixed effects of the measures of integration on efficiency challenge the notion that integration of HIV and SRH services may substantially improve the technical efficiency of health facilities. The analysis of quality and efficiency as separate dimensions of performance suggest that efficiency may be achieved without sacrificing quality. PMID:26803655

Does integration of HIV and sexual and reproductive health services improve technical efficiency in Kenya and Swaziland? An application of a two-stage semi parametric approach incorporating quality measures.

PubMed

Obure, Carol Dayo; Jacobs, Rowena; Guinness, Lorna; Mayhew, Susannah; Vassall, Anna

2016-02-01

Theoretically, integration of vertically organized services is seen as an important approach to improving the efficiency of health service delivery. However, there is a dearth of evidence on the effect of integration on the technical efficiency of health service delivery. Furthermore, where technical efficiency has been assessed, there have been few attempts to incorporate quality measures within efficiency measurement models particularly in sub-Saharan African settings. This paper investigates the technical efficiency and the determinants of technical efficiency of integrated HIV and sexual and reproductive health (SRH) services using data collected from 40 health facilities in Kenya and Swaziland for 2008/2009 and 2010/2011. Incorporating a measure of quality, we estimate the technical efficiency of health facilities and explore the effect of integration and other environmental factors on technical efficiency using a two-stage semi-parametric double bootstrap approach. The empirical results reveal a high degree of inefficiency in the health facilities studied. The mean bias corrected technical efficiency scores taking quality into consideration varied between 22% and 65% depending on the data envelopment analysis (DEA) model specification. The number of additional HIV services in the maternal and child health unit, public ownership and facility type, have a positive and significant effect on technical efficiency. However, number of additional HIV and STI services provided in the same clinical room, proportion of clinical staff to overall staff, proportion of HIV services provided, and rural location had a negative and significant effect on technical efficiency. The low estimates of technical efficiency and mixed effects of the measures of integration on efficiency challenge the notion that integration of HIV and SRH services may substantially improve the technical efficiency of health facilities. The analysis of quality and efficiency as separate dimensions of performance suggest that efficiency may be achieved without sacrificing quality. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Principles and Procedures in Technical Assistance: An Approach to Educational Change

ERIC Educational Resources Information Center

Lillie, David L.; Black, Talbot

1976-01-01

The Technical Assistance Development System (TADS) has developed through the years a system for technical assistance and has identified some important principles that should be followed in the operation of organizational support systems. (Author/ER)

Review of ecological-based risk management approaches used at five Army Superfund sites.

PubMed

Poucher, Sherri L; Tracey, Gregory A; Johnson, Mark S; Haines, Laurie B

2012-04-01

Factors used in environmental remedial decision making concerning ecological risk are not well understood or necessarily consistent. Recent Records of Decision (RODs) for Army CERCLA sites were reviewed to select case studies where remedial management occurred in response to ecological risks. Thirty-four Army RODs were evaluated representing decisions promulgated between 1996 and 2004. Five were selected based on assessments that remedial actions were clearly linked to concern for ecological receptors. The Ecological Risk Assessment (ERA) approach and the subsequent risk management process were reviewed for each site. The case studies demonstrated that the ERA findings, as well as critical management decisions regarding interpretation of identified ecological risks, were determinants of remedial action objectives. Decisions regarding the selection of remedial alternatives were based on a set of criteria prescribed by Superfund requirements and guidance. Remedial alternative evaluations require protection of human health and the environment, but protective conditions were determined using different methods at each site. Examining the remedial management process for the 5 case study sites revealed that uncertainty in the risk assessment and decisions regarding appropriate spatial scales for both risk assessment and remediation were important factors influencing remedial action decisions. The case reviews also revealed that levels of documentation were variable from site to site. In the future, more detailed documentation of decision criteria and the development of criteria that consider the resilience of the site will result in more technically defensible ecological risk management. Copyright © 2011 SETAC.

Radar-cross-section reduction of wind turbines. part 1.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brock, Billy C.; Loui, Hung; McDonald, Jacob J.

2012-03-05

In recent years, increasing deployment of large wind-turbine farms has become an issue of growing concern for the radar community. The large radar cross section (RCS) presented by wind turbines interferes with radar operation, and the Doppler shift caused by blade rotation causes problems identifying and tracking moving targets. Each new wind-turbine farm installation must be carefully evaluated for potential disruption of radar operation for air defense, air traffic control, weather sensing, and other applications. Several approaches currently exist to minimize conflict between wind-turbine farms and radar installations, including procedural adjustments, radar upgrades, and proper choice of low-impact wind-farm sites,more » but each has problems with limited effectiveness or prohibitive cost. An alternative approach, heretofore not technically feasible, is to reduce the RCS of wind turbines to the extent that they can be installed near existing radar installations. This report summarizes efforts to reduce wind-turbine RCS, with a particular emphasis on the blades. The report begins with a survey of the wind-turbine RCS-reduction literature to establish a baseline for comparison. The following topics are then addressed: electromagnetic model development and validation, novel material development, integration into wind-turbine fabrication processes, integrated-absorber design, and wind-turbine RCS modeling. Related topics of interest, including alternative mitigation techniques (procedural, at-the-radar, etc.), an introduction to RCS and electromagnetic scattering, and RCS-reduction modeling techniques, can be found in a previous report.« less

Towards better environmental performance of wastewater sludge treatment using endpoint approach in LCA methodology.

PubMed

Alyaseri, Isam; Zhou, Jianpeng

2017-03-01

The aim of this study is to use the life cycle assessment method to measure the environmental performance of the sludge incineration process in a wastewater treatment plant and to propose an alternative that can reduce the environmental impact. To show the damages caused by the treatment processes, the study aimed to use an endpoint approach in evaluating impacts on human health, ecosystem quality, and resources due to the processes. A case study was taken at Bissell Point Wastewater Treatment Plant in Saint Louis, Missouri, U.S. The plant-specific data along with literature data from technical publications were used to build an inventory, and then analyzed the environmental burdens from sludge handling unit in the year 2011. The impact assessment method chosen was ReCipe 2008. The existing scenario (dewatering-multiple hearth incineration-ash to landfill) was evaluated and three alternative scenarios (fluid bed incineration and anaerobic digestion with and without land application) with energy recovery from heat or biogas were proposed and analyzed to find the one with the least environmental impact. The existing scenario shows that the most significant impacts are related to depletion in resources and damage to human health. These impacts mainly came from the operation phase (electricity and fuel consumption and emissions related to combustion). Alternatives showed better performance than the existing scenario. Using ReCipe endpoint methodology, and among the three alternatives tested, the anaerobic digestion had the best overall environmental performance. It is recommended to convert to fluid bed incineration if the concerns were more about human health or to anaerobic digestion if the concerns were more about depletion in resources. The endpoint approach may simplify the outcomes of this study as follows: if the plant is converted to fluid bed incineration, it could prevent an average of 43.2 DALYs in human life, save 0.059 species in the area from extinction, and make a 62% reduction in the plant's current expenses needed by future generations to extract resources per year. At the same time it may prevent 36.1 DALYs in humans, save 0.157 species, and make a 101% reduction in current expenses on resources per year, if converting to anaerobic digestion.

Risk assessments for mixtures: technical methods commonly used in the United States

EPA Science Inventory

A brief (20 minute) talk on the technical approaches used by EPA and other US agencies to assess risks posed by combined exposures to one or more chemicals. The talk systemically reviews the methodologies (whole-mixtures and component-based approaches) that are or have been used ...

Learning to Teach and Do

ERIC Educational Resources Information Center

Warren, Thomas L.

2015-01-01

Teaching technical writing without formal training can be daunting. However, there are many resources available that can provide background and materials for teaching. My approach involved reading textbooks and articles not only on approaches to technical writing but also on what students can expect once they complete their education and are…

Report of the analysis of the joint medium range air to surface missile program

NASA Astrophysics Data System (ADS)

1980-01-01

The objective of this effort completed between July, 1979 and January, 1980 was to investigate technical alternatives and make recommendations concerning management approaches to accomplish the project goals. The purpose of this report is to formalize those recommendations and to identify future courses of action alternatives. The basic concepts incorporated in a supersonic stand-off, air-to-surface missile have existed in Navy advance planning for many years. Navy action on this concept was formalized in 1967 with the decision to initiate a funded technology program to produce a system technology prototype of an advance tactical stand-off missile. Parallel development of propulsion, guidance, and other subsystem technologies conducted by the Air Force, industry, and other countries have also contributed to the current technology base. In May 1978, the Chief of Naval Operations established a requirement for a survivable medium range air-to-surface missile with the issuance of operational requirement W-0650-TW, 'Medium Range Air-to-Surface Missile'. The requirements delineate the need for an offensive air-to-surface missile that can penetrate and survive against defenses expected to be encountered in the 80's and 90's.

Electricity generation by direct oxidation of glucose in mediatorless microbial fuel cells.

PubMed

Chaudhuri, Swades K; Lovley, Derek R

2003-10-01

Abundant energy, stored primarily in the form of carbohydrates, can be found in waste biomass from agricultural, municipal and industrial sources as well as in dedicated energy crops, such as corn and other grains. Potential strategies for deriving useful forms of energy from carbohydrates include production of ethanol and conversion to hydrogen, but these approaches face technical and economic hurdles. An alternative strategy is direct conversion of sugars to electrical power. Existing transition metal-catalyzed fuel cells cannot be used to generate electric power from carbohydrates. Alternatively, biofuel cells in which whole cells or isolated redox enzymes catalyze the oxidation of the sugar have been developed, but their applicability has been limited by several factors, including (i) the need to add electron-shuttling compounds that mediate electron transfer from the cell to the anode, (ii) incomplete oxidation of the sugars and (iii) lack of long-term stability of the fuel cells. Here we report on a novel microorganism, Rhodoferax ferrireducens, that can oxidize glucose to CO(2) and quantitatively transfer electrons to graphite electrodes without the need for an electron-shuttling mediator. Growth is supported by energy derived from the electron transfer process itself and results in stable, long-term power production.

42 CFR 431.424 - Evaluation requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... evaluations. Demonstration evaluations will include the following: (1) Quantitative research methods. (i... of appropriate evaluation strategies (including experimental and other quantitative and qualitative... demonstration. (ii) CMS will consider alternative evaluation designs when quantitative designs are technically...

42 CFR 431.424 - Evaluation requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... evaluations. Demonstration evaluations will include the following: (1) Quantitative research methods. (i... of appropriate evaluation strategies (including experimental and other quantitative and qualitative... demonstration. (ii) CMS will consider alternative evaluation designs when quantitative designs are technically...