Spontaneous myometrial contractility in cows suffering from endometritis-Influence of localisation, smooth muscle layer and cycle phase. An in vitro study.

PubMed

Hirsbrunner, Gaby; Kaufmann, Ch; Keller, Ch; Hüsler, J; Steiner, A

2010-04-01

Contractility of the healthy bovine myometrium depends on the reproductive state. Furthermore, contractility is influenced by localisation and the direction of smooth muscle strips. However, little is known about the contractile behaviour of the uterus when affected by endometritis. In our study, myometrial specimens from the larger horn (near the corpus and near the tip) in cows suffering from endometritis in estrus (n=8) or diestrus (n=8) were collected after slaughter. Two strips were prepared from each region corresponding to the circular and the longitudinal muscle layers, respectively. The spontaneous contractility of these strips was recorded in an organ bath. To analyse the results, the 2.5h recordings were divided into five periods of 30 min each. The variables area under curve (AUC) and maximal (A(max)) and minimal amplitude (A(min)) were calculated separately for each period, and the results were analysed using a non-parametric model regarding the influence of cycle phase (estrus vs. diestrus), region (corpus vs. tip) and muscle layer (circular vs. longitudinal). The values of both AUC and A(max) increased significantly over time. Muscle layer had a significant effect on AUC (corpus, tip) and A(max) (tip): the values of circular layers were increased compared to longitudinal layers. Dividing the data into subgroups allowed us to analyse them additionally according to muscle layer: In longitudinal layers, A(max) was increased at the corpus as compared with the tip. In this model, the factor cycle phase did not produce any significant difference in spontaneous myometrial activity. However, data of all variables showed non-significant higher values in estrus than in diestrus samples. Copyright 2009 Elsevier B.V. All rights reserved.

Light adaptation and dark adaptation of human rod photoreceptors measured from the a-wave of the electroretinogram

PubMed Central

Thomas, M M; Lamb, T D

1999-01-01

We recorded the a-wave of the human electroretinogram from subjects with normal vision, using a corneal electrode and ganzfeld (full-field) light stimulation. From analysis of the rising phase of rod-isolated flash responses we determined the maximum size (amax) of the a-wave, a measure of the massed circulating current of the rods, and the amplification constant (A) of transduction within the rod photoreceptors.During light adaptation by steady backgrounds the maximal response was reduced, as reported previously. amax declined approximately as I0/(I0+IB), where IB is retinal illuminance and I0 is a constant. In different subjects I0 ranged from 40 to 100 trolands, with a mean of 70 trolands, corresponding to about 600 photoisomerizations s−1 per rod. (1 troland is the retinal illuminance that results when a surface luminance of 1 cd m−2 is viewed through a pupil area of 1 mm2.) The amplification constant A decreased only slightly in the presence of steady backgrounds.Following a full bleach amax recovered along an S-shaped curve over a period of 30 min. There was no detectable response for the first 5 min, and half-maximal recovery took 13-17 min.The apparent amplification constant decreased at early times after large bleaches. However, upon correction for reduced light absorption due to loss of pigment, with regeneration of rhodopsin occurring with a time constant of 9-15 min in different subjects, it appeared that the true value of A was probably unchanged by bleaching.The recovery of amax following a bleach could be converted into recovery of equivalent background intensity, using a ‘Crawford transformation’ derived from the light adaptation results. Following bleaches ranging from 10 to > 99 %, the equivalent background intensity decayed approximately exponentially, with a time constant of about 3 min.The time taken for amax to recover to a fixed proportion of its original level increased approximately linearly (rather than logarithmically) with fractional bleach, with a slope of about 12 min per 100 % bleach. Similar behaviour has previously been seen in psychophysical dark adaptation experiments, for the dependence of the ‘second component’ of recovery on the level of bleaching. PMID:10381594

Constraints on Planetary Companions in the Magnification A=256 Microlensing Event OGLE-2003-BLG-423

NASA Astrophysics Data System (ADS)

Yoo, Jaiyul; DePoy, D. L.; Gal-Yam, A.; Gaudi, B. S.; Gould, A.; Han, C.; Lipkin, Y.; Maoz, D.; Ofek, E. O.; Park, B.-G.; Pogge, R. W.; Mu Fun Collaboration; Szymański, M. K.; Udalski, A.; Szewczyk, O.; Kubiak, M.; Żebruń, K.; Pietrzyński, G.; Soszyński, I.; Wyrzykowski, Ł.; OGLE Collaboration

2004-12-01

We develop a new method of modeling microlensing events based on a Monte Carlo simulation that incorporates both a Galactic model and the constraints imposed by the observed characteristics of the event. The method provides an unbiased way to analyze the event, especially when parameters are poorly constrained by the observed light curve. We apply this method to search for planetary companions of the lens in OGLE-2003-BLG-423, whose maximum magnification Amax=256+/-43 (or Amax=400+/-115 from the light-curve data alone) is the highest among single-lens events ever recorded. The method permits us for the first time to place constraints directly in the planet mass-projected physical separation plane rather than in the mass ratio-Einstein radius plane as was done previously. For example, Jovian-mass companions of main-sequence stars at 2.5 AU are excluded with 80% efficiency. Based in part on observations obtained with the 1.3 m Warsaw Telescope at the Las Campanas Observatory of the Carnegie Institution of Washington.

Nitrogen can improve the rapid response of photosynthesis to changing irradiance in rice (Oryza sativa L.) plants.

PubMed

Sun, Jiali; Ye, Miao; Peng, Shaobing; Li, Yong

2016-08-10

To identify the effect of nitrogen (N) nutrition on the dynamic photosynthesis of rice plants, a pot experiment was conducted under two N conditions. The leaf N and chlorophyll levels, as well as steady-state photosynthesis, were significantly increased under high N. After the transition from saturating to low light levels, decreases in the induction state (IS%) of leaf photosynthesis (A) and stomatal conductance (gs) were more severe under low than under high N supply. After the transition from low to flecked irradiance, the times to 90% of maximum A (T90%A) were significantly longer under low than under high N supply. Under flecked irradiance, the maximum A under saturating light (Amax-fleck) and the steady-state A under low light (Amin-fleck) were both lower than those under uniform irradiance (Asat and Ainitial). Under high N supply, Amax-fleck was 14.12% lower than Asat, while it was 22.80% lower under low N supply. The higher IS%, shorter T90%A, and the lower depression of Amax-fleck from Asat under high N supply led to a less carbon loss compared with under a low N supply. Therefore, we concluded that N can improve the rapid response of photosynthesis to changing irradiance.

Universal Linear Fit Identification: A Method Independent of Data, Outliers and Noise Distribution Model and Free of Missing or Removed Data Imputation.

PubMed

Adikaram, K K L B; Hussein, M A; Effenberger, M; Becker, T

2015-01-01

Data processing requires a robust linear fit identification method. In this paper, we introduce a non-parametric robust linear fit identification method for time series. The method uses an indicator 2/n to identify linear fit, where n is number of terms in a series. The ratio Rmax of amax - amin and Sn - amin*n and that of Rmin of amax - amin and amax*n - Sn are always equal to 2/n, where amax is the maximum element, amin is the minimum element and Sn is the sum of all elements. If any series expected to follow y = c consists of data that do not agree with y = c form, Rmax > 2/n and Rmin > 2/n imply that the maximum and minimum elements, respectively, do not agree with linear fit. We define threshold values for outliers and noise detection as 2/n * (1 + k1) and 2/n * (1 + k2), respectively, where k1 > k2 and 0 ≤ k1 ≤ n/2 - 1. Given this relation and transformation technique, which transforms data into the form y = c, we show that removing all data that do not agree with linear fit is possible. Furthermore, the method is independent of the number of data points, missing data, removed data points and nature of distribution (Gaussian or non-Gaussian) of outliers, noise and clean data. These are major advantages over the existing linear fit methods. Since having a perfect linear relation between two variables in the real world is impossible, we used artificial data sets with extreme conditions to verify the method. The method detects the correct linear fit when the percentage of data agreeing with linear fit is less than 50%, and the deviation of data that do not agree with linear fit is very small, of the order of ±10-4%. The method results in incorrect detections only when numerical accuracy is insufficient in the calculation process.

Seasonal patterns of photosynthetic gas-exchange and leaf reflectance characteristics in male and female riparian cottonwoods of southern Alberta

NASA Astrophysics Data System (ADS)

Letts, M. G.; Phelan, C. A.; Johnson, D. R.; Pearce, D. W.; Rood, S. B.

2007-12-01

Riparian, or streamside, cottonwood trees ( Populus spp.) are dioecious phreatophytes of hydrological and ecological importance in arid and semi-arid ecosystems throughout the northern hemisphere. In southern Alberta, groundwater and soil moisture levels typically decline during the May to September growth season. To understand how narrowleaf cottonwoods ( Populus angustifolia James) respond to this seasonal decrease in moisture availability, we repeatedly measured photosynthetic gas exchange, leaf reflectance, chlorophyll fluorescence and stable carbon isotope composition (δ13C) in four male and four female trees of the Oldman River valley, throughout the 2006 growth season. Maximum light-saturated net photosynthesis rates (Amax), near 16 μmol m-2 s-1, occurred on day of year (DOY) 205, one month after peak soil moisture, but coincident with the maximum quantum efficiency of Photosystem II (Fv/Fm), chlorophyll index (CI) and scaled photochemical reflectance index (sPRI). CI data suggest that the early-season rise in Amax and Fv/Fm was partly due to growth in the chlorophyll pool. Thereafter, Amax fell to near 10 μmol m-2 s-1, largely due to its positive logarithmic relationship with stomatal conductance (gs; r2=0.89), which decreased from 559 to 246 mmol m-2 s-1 from DOY 205 to 237. The normalized difference vegetation index (NDVI), CI, sPRI and quantum yield of electron transfer at Photosystem II (ΦPSII) also declined in response to lower volumetric soil moisture content (θv) and increasing groundwater depth (Zgw). Little change in transpiration rate (E) was observed in response to changing environmental conditions, except on DOY 237, when a combination of unseasonably low vapour pressure deficit (D) and low θv above the deepening capillary fringe caused E to decrease. No significant difference was observed between the mean WUE (Amax/E) of males (2.1 ± 0.2 mmol mol-1) and females (2.5 ± 0.2 mmol mol-1; repeated measures ANOVA, df=6, F=2.39, p=0.16). Leaves of females showed a tendency for lower NDVI than those of males (repeated measures ANOVA, F=4.82, p=0.07). Otherwise, no significant differences were observed between males and females in any gas-exchange, leaf reflectance or fluorescence characteristic (repeated measures ANOVA, α=0.05) and δ13C remained in the -28.8 to -29.3 ‰ range throughout the season, in both sexes.

Physiological Effects of Kaolin Applications in Well-irrigated and Water-stressed Walnut and Almond Trees

PubMed Central

ROSATI, A.; METCALF, S. G.; BUCHNER, R. P.; FULTON, A. E.; LAMPINEN, B. D.

2006-01-01

• Background and Aims Kaolin applications have been used to mitigate the negative effects of water and heat stress on plant physiology and productivity with variable results, ranging from increased to decreased yields and photosynthetic rates. The mechanisms of action of kaolin applications are not clear: although the increased albedo reduces leaf temperature and the consequent heat stress, it also reduces the light available for photosynthesis, possibly offsetting benefits of lower temperature. The objective of this study was to investigate which of these effects are prevalent and under which conditions. • Methods A 6 % kaolin suspension was applied on well-irrigated and water-stressed walnut (Juglans regia) and almond (Prunus dulcis) trees. Water status (i.e. stem water potential, Ψs), gas exchange (i.e. light-saturated CO2 assimilation rate, Amax; stomatal conductance, gs), leaf temperature (Tl) and physiological relationships in treated and control trees were then measured and compared. • Key Results In both species, kaolin did not affect the daily course of Ψs whereas it reduced Amax by 1–4 μmol CO2 m–2 s–1 throughout the day in all combinations of species and irrigation treatments. Kaolin did not reduce gs in any situation. Consequently, intercellular CO2 concentration (Ci) was always greater in treated trees than in controls, suggesting that the reduction of Amax with kaolin was not due to stomatal limitations. Kaolin reduced leaf temperature (Tl) by about 1–3 °C and leaf-to-air vapour pressure difference (VPDl) by about 0·1–0·7 kPa. Amax was lower at all values of gs, Tl and VPDl in kaolin-treated trees. Kaolin affected the photosynthetic response to the photosynthetically active radiation (PAR) in almond leaves: kaolin-coated leaves had similar dark respiration rates and light-saturated photosynthesis, but a higher light compensation point and lower apparent quantum yield, while the photosynthetic light-response curve saturated at higher PAR. When these parameters were used to model the photosynthetic response curve to PAR, it was estimated that the kaolin film allowed 63 % of the incident PAR to reach the leaf. • Conclusions The main effect of kaolin application was the reduction, albeit minor, of photosynthesis, which appeared to be related to the shading of the leaves. The reduction in Tl and VPDl with kaolin did not suffice to mitigate the adverse effects of heat and water stress on Amax. PMID:16735404

Estimation of ground motion for Bhuj (26 January 2001; Mw 7.6 and for future earthquakes in India

USGS Publications Warehouse

Singh, S.K.; Bansal, B.K.; Bhattacharya, S.N.; Pacheco, J.F.; Dattatrayam, R.S.; Ordaz, M.; Suresh, G.; ,; Hough, S.E.

2003-01-01

Only five moderate and large earthquakes (Mw ???5.7) in India-three in the Indian shield region and two in the Himalayan arc region-have given rise to multiple strong ground-motion recordings. Near-source data are available for only two of these events. The Bhuj earthquake (Mw 7.6), which occurred in the shield region, gave rise to useful recordings at distances exceeding 550 km. Because of the scarcity of the data, we use the stochastic method to estimate ground motions. We assume that (1) S waves dominate at R < 100 km and Lg waves at R ??? 100 km, (2) Q = 508f0.48 is valid for the Indian shield as well as the Himalayan arc region, (3) the effective duration is given by fc-1 + 0.05R, where fc is the corner frequency, and R is the hypocentral distance in kilometer, and (4) the acceleration spectra are sharply cut off beyond 35 Hz. We use two finite-source stochastic models. One is an approximate model that reduces to the ??2-source model at distances greater that about twice the source dimension. This model has the advantage that the ground motion is controlled by the familiar stress parameter, ????. In the other finite-source model, which is more reliable for near-source ground-motion estimation, the high-frequency radiation is controlled by the strength factor, sfact, a quantity that is physically related to the maximum slip rate on the fault. We estimate ???? needed to fit the observed Amax and Vmax data of each earthquake (which are mostly in the far field). The corresponding sfact is obtained by requiring that the predicted curves from the two models match each other in the far field up to a distance of about 500 km. The results show: (1) The ???? that explains Amax data for shield events may be a function of depth, increasing from ???50 bars at 10 km to ???400 bars at 36 km. The corresponding sfact values range from 1.0-2.0. The ???? values for the two Himalayan arc events are 75 and 150 bars (sfact = 1.0 and 1.4). (2) The ???? required to explain Vmax data is, roughly, half the corresponding value for Amax, while the same sfact explains both sets of data. (3) The available far-field Amax and Vmax data for the Bhuj mainshock are well explained by ???? = 200 and 100 bars, respectively, or, equivalently, by sfact = 1.4. The predicted Amax and Vmax in the epicentral region of this earthquake are 0.80 to 0.95 g and 40 to 55 cm/sec, respectively.

Do Peatlands Hibernate?

NASA Astrophysics Data System (ADS)

Dorrepaal, E.; Signarbieux, C.; Jassey, V.; Mills, R.; Buttler, A.; Robroek, B.

2014-12-01

Winter seasonality with extensive frost, snow cover and low incoming radiation characterise large areas at mid- and high latitudes, especially in mountain ranges and in the arctic. Given these adverse conditions, it is often assumed that ecosystem processes, such as plant photosynthesis, nutrient uptake and microbial activities, cease, or at best diminish to marginal rates compared to summer. However, snow is a good thermal insulator and a sufficiently thick snow cover might enable temperature-limited processes to continue in winter, especially belowground. Changes in winter precipitation may alter these conditions, yet, relative to the growing season, winter ecosystem processes remain poorly understood. We performed a snow-removal experiment on an ombrotrophic bog in the Swiss Jura mountains (1036 m.a.s.l.) to compare above- and belowground ecosystem processes with and without snow cover during mid- and late-winter (February and April) with the subsequent spring (June) and summer (July). The presence of 1m snow in mid-winter and 0.4m snow in late-winter strongly reduced the photosynthetic capacity (Amax) of Eriophorum vaginatum as well as the total microbial biomass compared to spring and summer values. Amax of Sphagnum magellanicum and uptake of 15N-labelled ammonium-nitrate by vascular plants were, however, almost as high or higher in mid- and late-winter as in summer. Snow removal increased the number of freeze-thaw cycles in mid-winter but also increased the minimum soil temperature in late-winter before ambient snow-melt. This strongly reduced all measured ecosystem processes in mid-winter compared to control and to spring and summer values. Plant 15N-uptake, Amax of Eriophorum and total microbial biomass returned to, or exceeded, control values soon before or after snowmelt. However, Sphagnum Amax and its length growth, as well as the structure of the microbial community showed clear carry-over effects of the reduced winter snow cover into next summer. Altogether, our data indicate that peatlands are active in winter. However, a continuous snow cover is crucial for ecosystem processes both in winter and in the subsequent summer and a reduction of snow thickness or duration due to climate change may impact on peatland ecosystem functioning at various levels.

Does long-term cultivation of saplings under elevated CO2 concentration influence their photosynthetic response to temperature?

PubMed Central

Šigut, Ladislav; Holišová, Petra; Klem, Karel; Šprtová, Mirka; Calfapietra, Carlo; Marek, Michal V.; Špunda, Vladimír; Urban, Otmar

2015-01-01

Background and Aims Plants growing under elevated atmospheric CO2 concentrations often have reduced stomatal conductance and subsequently increased leaf temperature. This study therefore tested the hypothesis that under long-term elevated CO2 the temperature optima of photosynthetic processes will shift towards higher temperatures and the thermostability of the photosynthetic apparatus will increase. Methods The hypothesis was tested for saplings of broadleaved Fagus sylvatica and coniferous Picea abies exposed for 4–5 years to either ambient (AC; 385 µmol mol−1) or elevated (EC; 700 µmol mol−1) CO2 concentrations. Temperature response curves of photosynthetic processes were determined by gas-exchange and chlorophyll fluorescence techniques. Key Results Initial assumptions of reduced light-saturated stomatal conductance and increased leaf temperatures for EC plants were confirmed. Temperature response curves revealed stimulation of light-saturated rates of CO2 assimilation (Amax) and a decline in photorespiration (RL) as a result of EC within a wide temperature range. However, these effects were negligible or reduced at low and high temperatures. Higher temperature optima (Topt) of Amax, Rubisco carboxylation rates (VCmax) and RL were found for EC saplings compared with AC saplings. However, the shifts in Topt of Amax were instantaneous, and disappeared when measured at identical CO2 concentrations. Higher values of Topt at elevated CO2 were attributed particularly to reduced photorespiration and prevailing limitation of photosynthesis by ribulose-1,5-bisphosphate (RuBP) regeneration. Temperature response curves of fluorescence parameters suggested a negligible effect of EC on enhancement of thermostability of photosystem II photochemistry. Conclusions Elevated CO2 instantaneously increases temperature optima of Amax due to reduced photorespiration and limitation of photosynthesis by RuBP regeneration. However, this increase disappears when plants are exposed to identical CO2 concentrations. In addition, increased heat-stress tolerance of primary photochemistry in plants grown at elevated CO2 is unlikely. The hypothesis that long-term cultivation at elevated CO2 leads to acclimation of photosynthesis to higher temperatures is therefore rejected. Nevertheless, incorporating acclimation mechanisms into models simulating carbon flux between the atmosphere and vegetation is necessary. PMID:25851132

Convergent acclimation of leaf photosynthesis and respiration to prevailing ambient temperatures under current and warmer climates in Eucalyptus tereticornis.

PubMed

Aspinwall, Michael J; Drake, John E; Campany, Courtney; Vårhammar, Angelica; Ghannoum, Oula; Tissue, David T; Reich, Peter B; Tjoelker, Mark G

2016-10-01

Understanding physiological acclimation of photosynthesis and respiration is important in elucidating the metabolic performance of trees in a changing climate. Does physiological acclimation to climate warming mirror acclimation to seasonal temperature changes? We grew Eucalyptus tereticornis trees in the field for 14 months inside 9-m tall whole-tree chambers tracking ambient air temperature (Tair ) or ambient Tair  + 3°C (i.e. 'warmed'). We measured light- and CO2 -saturated net photosynthesis (Amax ) and night-time dark respiration (R) each month at 25°C to quantify acclimation. Tree growth was measured, and leaf nitrogen (N) and total nonstructural carbohydrate (TNC) concentrations were determined to investigate mechanisms of acclimation. Warming reduced Amax and R measured at 25°C compared to ambient-grown trees. Both traits also declined as mean daily Tair increased, and did so in a similar way across temperature treatments. Amax and R (at 25°C) both increased as TNC concentrations increased seasonally; these relationships appeared to arise from source-sink imbalances, suggesting potential substrate regulation of thermal acclimation. We found that photosynthesis and respiration each acclimated equivalently to experimental warming and seasonal temperature change of a similar magnitude, reflecting a common, nearly homeostatic constraint on leaf carbon exchange that will be important in governing tree responses to climate warming. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Photosynthesis, plant growth and nitrogen nutrition in Alaskan tussock tundra: Response to experimental warming

NASA Astrophysics Data System (ADS)

Dynes, E.; Welker, J. M.; Moore, D. J.; Sullivan, P.; Ebbs, L.; Pattison, R.

2009-12-01

Temperature is predicted to rise significantly in northern latitudes over the next century. The Arctic tundra is a fragile ecosystem with low rates of photosynthesis and low nutrient mineralisation. Rising temperatures may increase photosynthetic capacity in the short term through direct stimulation of photosynthetic rates and also in the longer term due to enhanced nutrient availability. Different species and plant functional types may have different responses to warming which may have an impact on plant community structure. As part of the International Tundra Experiment (ITEX) to investigate the effects of warming on arctic vegetation, a series of open top chambers (OTCs) have been established at the Toolik Field Station (68°38’N, 149°36’W, elevation 720 m). This study employs 12 plots; 6 control plots and 6 warming plots covered with OTCs which maintain a temperature on average +1.54 °C degrees higher than ambient temperatures. The response of photosynthesis to temperature was measured using an infra-red gas analyzer (IRGA) with a cooling adaptor to manipulate leaf temperature and determine AMAX in two contrasting species, Eriophorum vaginatum (sedge) and Betula nana (shrub). Temperature within the chamber head of the IRGA was manipulated from 10 through 25 °C. We also measured the leaf area index of plots using a Decagon Accupar Ceptometer to provide insights into potential differences in canopy cover. In both OTC and control plots the photosynthetic rate of B. nana was greater than that of E. vaginatum, with the AMAX of B. nana peaking at 20.08°C and E. vaginatum peaking slightly lower at 19.7°C in the control plots. There was no apparent difference in the temperature optimum of photosynthesis of either species when exposed to the warming treatment. Although there was no difference in temperature optimum there were differences in the peak values of AMAX between treatment and control plots. In the case of B. nana, AMAX was higher in the OTCs than in the control plots with the highest rate being 17.2 μmol/m2/s in OTCs and 16.8 μmol/m2/s in control. Similarly, AMAX of E. vaginatum was also higher in OTCs with the highest rate being 10.4 μmol/m2/s in the control and 11 μmol/m2/s in the OTCs. Leaf area (LAI) was higher in the warming plots (mean = .39(0.095)) than LAI in the control plots (mean =.3 (.067)) in the control plots. This difference was significant as p<0.05. The higher photosynthetic rate and temperature optimum of photosynthesis in B. nana may indicate shrubs ability to cope with rising temperatures more efficiently than E. vagination which may lead to shifts in total leaf area and species composition.

Inter- and intraspecific variation in leaf economic traits in wheat and maize

PubMed Central

Hale, Christine E; Cerabolini, Bruno E L; Cornelissen, Johannes H C; Craine, Joseph; Gough, William A; Kattge, Jens; Tirona, Cairan K F

2018-01-01

Abstract Leaf Economics Spectrum (LES) trait variation underpins multiple agroecological processes and many prominent crop yield models. While there are numerous independent studies assessing trait variation in crops, to date there have been no comprehensive assessments of intraspecific trait variation (ITV) in LES traits for wheat and maize: the world’s most widespread crops. Using trait databases and peer-reviewed literature, we compiled over 700 records of specific leaf area (SLA), maximum photosynthetic rates (Amax) and leaf nitrogen (N) concentrations, for wheat and maize. We evaluated intraspecific LES trait variation, and intraspecific trait–environment relationships. While wheat and maize occupy the upper 90th percentile of LES trait values observed across a global species pool, ITV ranged widely across the LES in wheat and maize. Fertilization treatments had strong impacts on leaf N, while plant developmental stage (here standardized as the number of days since planting) had strong impacts on Amax; days since planting, N fertilization and irrigation all influenced SLA. When controlling for these factors, intraspecific responses to temperature and precipitation explained 39.4 and 43.7 % of the variation in Amax and SLA, respectively, but only 5.4 % of the variation in leaf N. Despite a long history of domestication in these species, ITV in wheat and maize among and within cultivars remains large. Intraspecific trait variation is a critical consideration to refine regional to global models of agroecosystem structure, function and food security. Considerable opportunities and benefits exist for consolidating a crop trait database for a wider range of domesticated plant species. PMID:29484152

Extreme multi-basin fluvial flows and their relationship to extra-tropical cyclones

NASA Astrophysics Data System (ADS)

De Luca, Paolo; Hillier, John K.; Wilby, Robert L.; Quinn, Nevil W.; Harrigan, Shaun

2017-04-01

Fluvial floods are typically investigated as 'events' at the single basin scale, thereby implicitly assuming that severe flooding impacts each catchment independently from those nearby. A statistical analysis of the spatio-temporal characteristics of extreme flows in Great Britain (GB), during 1975-2014, is presented. These observations deepen understanding of the processes leading to multi-basin floods and present helpful insights for contingency planning and emergency responders. The largest multi-basin peak flow events within different time windows were identified by counting the number of coincident annual maximum river peak flows (AMAX) across 261 non-nested catchments, using search windows of 1 to 19 days. This showed that up to 107 basins reached their AMAX within the same plateauing 13-day window, draining a total area equivalent to ˜46% of the overall basins considered, which is an equivalent fraction of ˜27% of Great Britain. Such episodes are typically associated with persistent cyclonic atmospheric circulation and saturated ground, combined with short hydrological response times (<48 h) from large contributing basins. The most spatially extensive episodes also tend to coincide with the most severe gales (i.e. extra-tropical cyclones) on a ±0-13 day time-scale. The analysis suggests that multi-basin peak flow events can be characterised by concurrent peak flow AMAX and that the most extreme are driven by very severe gales (VSG). This has implications for emergency response including planning for combined flood-wind impacts (on for example power and communication systems), meaning that the emergency preparedness need to be reorganised in order to face this peril.

Nitrogen deposition's role in determining forest photosynthetic capacity; a FLUXNET synthesis

NASA Astrophysics Data System (ADS)

Fleischer, K.; Rebel, K.; van der Molen, M.; Erisman, J.; Wassen, M.; Dolman, H.

2011-12-01

There is growing evidence that nitrogen (N) deposition stimulates forest growth, as many forest ecosystems are N-limited. However, the significance of N deposition in determining the strength of the present and future terrestrial carbon sink is strongly debated. We investigated and quantified the effect of N deposition on ecosystem photosynthetic capacity (Amax) with the FLUXNET database, including 80 forest sites, covering the major forest types and climates of the world. The relative effect of climate and N deposition on photosynthesis was assessed with regression models. We found a significant positive correlation of Amax and N deposition for evergreen needleleaf forests in our dataset. We further found indications that foliar N and LAI scale positively with N deposition, reflecting the 2 mechanisms at which N is believed to cause an increase in carbon gain. We can support the hypothesis that foliar N is the principal scaling factor for canopy Amax across all forest types. Deciduous forests are less diverse in terms of climate and nutritional conditions for the included sites and these forests exhibited weak to no correlations with the included climate and N predictor variables. Quantifying the effect of N deposition on photosynthetic rates at the canopy level is an essential step for quantifying its contribution to the terrestrial carbon sink and for predicting vegetation response to N fertilization and global change in the future. The approach shows that eddy-covariance measurements of carbon fluxes at the canopy scale allow us to test hypotheses with respect to the expected nitrogen-photosynthesis relationships at the canopy scale.

Higher stability in forest-atmosphere exchange observed in a structurally diverse forest.

NASA Astrophysics Data System (ADS)

Tamrakar, R.; Rayment, M.; Moyano, F.; Herbst, M.; Mund, M.; Knohl, A.

2016-12-01

We tested the hypothesis that structurally diverse forests have greater stability on exchange processes with the atmosphere compared to forests with less diverse structure. In a case study, we assessed how net ecosystem exchange (NEE) and normalized maximum assimilation (Amax) varied over time in two forests in Germany based on 11 years of continuous eddy flux measurements. The two sites differ in structure as well as in species composition: one (Hainich) is an unmanaged, uneven-aged and heterogeneous mixed beech forest (65% beech), the other (Leinefelde) is a managed, even-aged and homogeneous pure beech stand. The two selected forests are of similar mean ages (about 130 years old) and exposed to similar air temperatures and vapour pressure deficits. Even though Hainich (the unmanaged forest) received higher rainfall (720 ± 134 mm vs 599±166 mm), the soil water availability showed no significant difference between both sites. Based on detailed biomass inventory, trees in Hainich are well distributed in all diameter at breast height (dbh) classes (10 to 90cm dbh) whereas in Leinefelde (the managed forest) trees are mostly confined to dbh classes of 40 to 55 cm. Our results showed a strong difference in inter-annual variability of NEE, which was lower in the unmanaged than in the managed site (coefficient of variation (CV) of 0.13 and 0.27, respectively). The lowest NEE was observed in both sites in 2004, a mast year and a year after the strong summer drought of 2003. The variation in the inter-annual normalized maximum assimilation (Amax) was lower in Hainich (standard deviation of 2.5 compared to 3.9 µmol m-2 s-1). Also, the seasonal course of Amax differed between the two forests which could explain why the mixed forest was more affected by the late summer drought of 2003, despite showing a more conservative carbon budget than the pure stand in the long term. The interannual anomaly in Amax was correlated with fruit production, the latter being larger in Leinefelde (CV of 1.37 vs. 1.18). Our data provide evidence from a case study that exchange processes with the atmosphere are more stable in structurally diverse forests, yet a confirmation covering multiple sites is still pending.

Genetic Adaptation vs. Ecophysiological Plasticity of Photosynthetic-Related Traits in Young Picea glauca Trees along a Regional Climatic Gradient

PubMed Central

Benomar, Lahcen; Lamhamedi, Mohammed S.; Rainville, André; Beaulieu, Jean; Bousquet, Jean; Margolis, Hank A.

2016-01-01

Assisted population migration (APM) is the intentional movement of populations within a species range to sites where future environmental conditions are projected to be more conducive to growth. APM has been proposed as a proactive adaptation strategy to maintain forest productivity and to reduce the vulnerability of forest ecosystems to projected climate change. The validity of such a strategy will depend on the adaptation capacity of populations, which can partially be evaluated by the ecophysiological response of different genetic sources along a climatic gradient. This adaptation capacity results from the compromise between (i) the degree of genetic adaptation of seed sources to their environment of origin and (ii) the phenotypic plasticity of functional trait which can make it possible for transferred seed sources to positively respond to new growing conditions. We examined phenotypic variation in morphophysiological traits of six seed sources of white spruce (Picea glauca [Moench] Voss) along a regional climatic gradient in Québec, Canada. Seedlings from the seed sources were planted at three forest sites representing a mean annual temperature (MAT) gradient of 2.2°C. During the second growing season, we measured height growth (H2014) and traits related to resources use efficiency and photosynthetic rate (Amax). All functional traits showed an adaptive response to the climatic gradient. Traits such as H2014, Amax, stomatal conductance (gs), the ratio of mesophyll to stomatal conductance, water use efficiency, and photosynthetic nitrogen-use efficiency showed significant variation in both physiological plasticity due to the planting site and seed source variation related to local genetic adaptation. However, the amplitude of seed source variation was much less than that related to plantation sites in the area investigated. The six seed sources showed a similar level of physiological plasticity. H2014, Amax and gs, but not carboxylation capacity (Vcmax), were correlated and decreased with a reduction of the average temperature of the growing season at seed origin. The clinal variation in H2014 and Amax appeared to be driven by CO2 conductance. The presence of locally adapted functional traits suggests that the use of APM may have advantages for optimizing seed source productivity in future local climates. PMID:26870067

Leaf Morphology, Photosynthetic Performance, Chlorophyll Fluorescence, Stomatal Development of Lettuce (Lactuca sativa L.) Exposed to Different Ratios of Red Light to Blue Light

PubMed Central

Wang, Jun; Lu, Wei; Tong, Yuxin; Yang, Qichang

2016-01-01

Red and blue light are both vital factors for plant growth and development. We examined how different ratios of red light to blue light (R/B) provided by light-emitting diodes affected photosynthetic performance by investigating parameters related to photosynthesis, including leaf morphology, photosynthetic rate, chlorophyll fluorescence, stomatal development, light response curve, and nitrogen content. In this study, lettuce plants (Lactuca sativa L.) were exposed to 200 μmol⋅m−2⋅s−1 irradiance for a 16 h⋅d−1 photoperiod under the following six treatments: monochromatic red light (R), monochromatic blue light (B) and the mixture of R and B with different R/B ratios of 12, 8, 4, and 1. Leaf photosynthetic capacity (Amax) and photosynthetic rate (Pn) increased with decreasing R/B ratio until 1, associated with increased stomatal conductance, along with significant increase in stomatal density and slight decrease in stomatal size. Pn and Amax under B treatment had 7.6 and 11.8% reduction in comparison with those under R/B = 1 treatment, respectively. The effective quantum yield of PSII and the efficiency of excitation captured by open PSII center were also significantly lower under B treatment than those under the other treatments. However, shoot dry weight increased with increasing R/B ratio with the greatest value under R/B = 12 treatment. The increase of shoot dry weight was mainly caused by increasing leaf area and leaf number, but no significant difference was observed between R and R/B = 12 treatments. Based on the above results, we conclude that quantitative B could promote photosynthetic performance or growth by stimulating morphological and physiological responses, yet there was no positive correlation between Pn and shoot dry weight accumulation. PMID:27014285

Photosynthetic capacity is negatively correlated with the concentration of leaf phenolic compounds across a range of different species

PubMed Central

Sumbele, Sally; Fotelli, Mariangela N.; Nikolopoulos, Dimosthenis; Tooulakou, Georgia; Liakoura, Vally; Liakopoulos, Georgios; Bresta, Panagiota; Dotsika, Elissavet; Adams, Mark A.; Karabourniotis, George

2012-01-01

Background and aims Phenolic compounds are the most commonly studied of all secondary metabolites because of their significant protective–defensive roles and their significant concentration in plant tissues. However, there has been little study on relationships between gas exchange parameters and the concentration of leaf phenolic compounds (total phenolics (TP) and condensed tannins (CT)) across a range of species. Therefore, we addressed the question: is there any correlation between photosynthetic capacity (Amax) and TP and CT across species from different ecosystems in different continents? Methodology A plethora of functional and structural parameters were measured in 49 plant species following different growth strategies from five sampling sites located in Greece and Australia. The relationships between several leaf traits were analysed by means of regression and principal component analysis. Principal results The results revealed a negative relationship between TP and CT and Amax among the different plant species, growth strategies and sampling sites, irrespective of expression (with respect to mass, area or nitrogen content). Principal component analysis showed that high concentrations of TP and CT are associated with thick, dense leaves with low nitrogen. This leaf type is characterized by low growth, Amax and transpiration rates, and is common in environments with low water and nutrient availability, high temperatures and high light intensities. Therefore, the high TP and CT in such leaves are compatible with the protective and defensive functions ascribed to them. Conclusions Our results indicate a functional integration between carbon gain and the concentration of leaf phenolic compounds that reflects the trade-off between growth and defence/protection demands, depending on the growth strategy adopted by each species. PMID:23050073

Photosynthetic capacity is negatively correlated with the concentration of leaf phenolic compounds across a range of different species.

PubMed

Sumbele, Sally; Fotelli, Mariangela N; Nikolopoulos, Dimosthenis; Tooulakou, Georgia; Liakoura, Vally; Liakopoulos, Georgios; Bresta, Panagiota; Dotsika, Elissavet; Adams, Mark A; Karabourniotis, George

2012-01-01

Phenolic compounds are the most commonly studied of all secondary metabolites because of their significant protective-defensive roles and their significant concentration in plant tissues. However, there has been little study on relationships between gas exchange parameters and the concentration of leaf phenolic compounds (total phenolics (TP) and condensed tannins (CT)) across a range of species. Therefore, we addressed the question: is there any correlation between photosynthetic capacity (A(max)) and TP and CT across species from different ecosystems in different continents? A plethora of functional and structural parameters were measured in 49 plant species following different growth strategies from five sampling sites located in Greece and Australia. The relationships between several leaf traits were analysed by means of regression and principal component analysis. The results revealed a negative relationship between TP and CT and A(max) among the different plant species, growth strategies and sampling sites, irrespective of expression (with respect to mass, area or nitrogen content). Principal component analysis showed that high concentrations of TP and CT are associated with thick, dense leaves with low nitrogen. This leaf type is characterized by low growth, A(max) and transpiration rates, and is common in environments with low water and nutrient availability, high temperatures and high light intensities. Therefore, the high TP and CT in such leaves are compatible with the protective and defensive functions ascribed to them. Our results indicate a functional integration between carbon gain and the concentration of leaf phenolic compounds that reflects the trade-off between growth and defence/protection demands, depending on the growth strategy adopted by each species.

Plasticity and stress tolerance override local adaptation in the responses of Mediterranean holm oak seedlings to drought and cold.

PubMed

Gimeno, Teresa E; Pías, Beatriz; Lemos-Filho, José P; Valladares, Fernando

2009-01-01

Plant populations of widely distributed species experience a broad range of environmental conditions that can be faced by phenotypic plasticity or ecotypic differentiation and local adaptation. The strategy chosen will determine a population's ability to respond to climate change. To explore this, we grew Quercus ilex (L.) seedlings from acorns collected at six selected populations from climatically contrasting localities and evaluated their response to drought and late season cold events. Maximum photosynthetic rate (A(max)), instantaneous water use efficiency (iWUE), and thermal tolerance to freeze and heat (estimated from chlorophyll fluorescence versus temperature curves) were measured in 5-month-old seedlings in control (no stress), drought (water-stressed), and cold (low suboptimal temperature) conditions. The observed responses were similar for the six populations: drought decreased A(max) and increased iWUE, and cold reduced A(max) and iWUE. All the seedlings maintained photosynthetic activity under adverse conditions (drought and cold), and rapidly increased their iWUE by closing stomata when exposed to drought. Heat and freeze tolerances were similarly high for seedlings from all the populations, and they were significantly increased by drought and cold, respectively; and were positively related to each other. Differences in seedling performance across populations were primarily induced by maternal effects mediated by seed size and to a lesser extent by idiosyncratic physiologic responses to drought and low temperatures. Tolerance to multiple stresses together with the capacity to physiologically acclimate to heat waves and cold snaps may allow Q. ilex to cope with the increasingly stressful conditions imposed by climate change. Lack of evidence of physiologic seedling adaptation to local climate may reflect opposing selection pressures to complex, multidimensional environmental conditions operating within the distribution range of this species.

High- and Low-Order Overtaking-Ability Affordances: Drivers Rely on the Maximum Velocity and Acceleration of Their Cars to Perform Overtaking Maneuvers.

PubMed

Basilio, Numa; Morice, Antoine H P; Marti, Geoffrey; Montagne, Gilles

2015-08-01

The aim of this study was to answer the question, Do drivers take into account the action boundaries of their car when overtaking? The Morice et al. affordance-based approach to visually guided overtaking suggests that the "overtake-ability" affordance can be formalized as the ratio of the "minimum satisfying velocity" (MSV) of the maneuver to the maximum velocity (V(max)) of the driven car. In this definition, however, the maximum acceleration (A(max)) of the vehicle is ignored. We hypothesize that drivers may be sensitive to an affordance redefined with the ratio of the "minimum satisfying acceleration" (MSA) to the A(max) of the car. Two groups of nine drivers drove cars differing in their A(max). They were instructed to attempt overtaking maneuvers in 25 situations resulting from the combination of five MSA and five MSV values. When overtaking frequency was expressed as a function of MSV and MSA, maneuvers were found to be initiated differently for the two groups. However, when expressed as a function of MSV/V(max) and MSA/A(max), overtaking frequency was quite similar for both groups. Finally, a multiple regression coefficient analysis demonstrated that overtaking decisions are fully explained by a composite variable comprising MSA/A(max) and the time required to reach MSV. Drivers reliably decide whether overtaking is safe (or not) by using low- and high-order variables taking into account their car's maximum velocity and acceleration, respectively, as predicted by "affordance-based control" theory. Potential applications include the design of overtaking assistance, which should exploit the MSA/A(max) variables in order to suggest perceptually relevant overtaking solutions. © 2015, Human Factors and Ergonomics Society.

Quantifying thermal constraints on carbon and water fluxes in a mixed-conifer sky island ecosystem

NASA Astrophysics Data System (ADS)

Braun, Z.; Minor, R. L.; Potts, D. L.; Barron-Gafford, G. A.

2012-12-01

Western North American forests represent a potential, yet uncertain, sink for atmospheric carbon. Revealing how predicted climatic conditions of warmer temperatures and longer inter-storm periods of moisture stress might influence the carbon status of these forests requires a fuller understanding of plant functional responses to abiotic stress. While data related to snow dominated montane ecosystems has become more readily available to parameterize ecosystem function models, there is a paucity of data available for Madrean sky island mixed-conifer forests, which receive about one third of their precipitation from the North American Monsoon. Thus, we quantified ecophysiological responses to moisture and temperature stress in a Madrean mixed-conifer forest near Tucson, Arizona, within the footprint of the Mt. Bigelow Eddy Covariance Tower. In measuring a series of key parameters indicative of carbon and water fluxes within the dominant species across pre-monsoon and monsoon conditions, we were able to develop a broader understanding of what abiotic drivers are most restrictive to plant performance in this ecosystem. Within Pinus ponderosa (Ponderosa Pine), Pseudotsuga menziesii (Douglas Fir), and Pinus strobiformis (Southwestern White Pine) we quantified: (i) the optimal temperature (Topt) for maximum photosynthesis (Amax), (ii) the range of temperatures over which photosynthesis was at least 50% of Amax (Ω50), and (iii) each conifer's water use efficiency (WUE) to relate to the balance between carbon uptake and water loss in this high elevation semiarid ecosystem. Our findings support the prediction that photosynthesis decreases under high temperatures (>30°C) among the three species we measured, regardless of soil moisture status. However, monsoon moisture reduced sensitivity to temperature extremes and fluctuations (Ω50), which substantially magnified total photosynthetic productivity. In particular, wet conditions enhanced Amax the most dramatically for P. menziesii, elevating rates by 590%, while Ω50 grew most substantially for P. strobifomis (by 180%). Interspecific differences in temperature optima (Topt) elucidated possible species dominance predictions for seasonal and gradual temperature changes. P. menziesii may out-perform the pine species in the event that temperatures rise in conjunction with abundant summer moisture. However, if monsoon rains fail to accumulate, P. menziesii may remain at subsistence levels of photosynthesis. Together, these data will enable the parameterization of models to approximate the productivity and, ultimately, the composition of Madrean sky island mixe d-conifer forests under forecasted climate conditions of increased temperatures and more frequent drought.

40 CFR 52.1335 - Compliance schedules.

Code of Federal Regulations, 2010 CFR

2010-07-01

... June 20, 1979 July 20, 1979 Mar. 1, 1984. St. Joe Minerals Corp., Pea Ridge Iron Ore Facility... Ridge Iron Ore Facility ......do ......do Apr. 22, 1981 Dec. 28, 1981 July 1, 1985. Associated Electric... Immediately Oct. 27, 1984. AMAX Lead Co Boss, MO ......do ......do ......do Apr. 27, 1985. (b) The compliance...

Eco-physiological Effects of Atmospheric Ozone and Polycyclic Aromatic Hydrocarbons (PAHs) on Plants

NASA Astrophysics Data System (ADS)

Bandai, S.; Sakugawa, H. H.

2012-12-01

[Introduction] Tropospheric ozone is one of most concerned air pollutant, by causing damage to trees and crops. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants found in various environmental compartments. Photo-induced toxicity of PAHs can be driven from formation of intracellular single oxygen and other reactive oxygen intermediates (ROI) leading to biological damages.(1) In the present study, we measured photosynthesis rate and other variables to investigate the effects of ozone and PAHs on the eco-physiological status of plants such as eggplant, common bean and strawberry. Plants treated with the single or combined air pollutants are expected to exhibit altered physiological, morphological and possibly growth changes. [Materials and Methods] We performed three exposure experiments. Exp.1. Eggplant (Solanum melongena) seedlings, were placed in the open-top chambers (n=6 plants/treatment). Treatment system was ozone (O)(120ppb), phenanthrene (P)(10μM), O+P, fluoranthene (F)(10μM), O+F, mannitol (M)(1mM) and the control (Milli-Q water)(C). P, F and M were sprayed three times weekly on the foliage part of eggplant. Average volume sprayed per seedling was 50mL. The treatment period was 30days and [AOT 40 (Accumulated exposure over a threshold of 40 ppb)]=28.8 ppmh. Exp.2, Common bean (Phaseolus vulgaris L.) seedlings were used (n=5 plants/treatment). The treatment system was the same as Exp.1. The treatment period was 40days and [AOT 40]=38.4ppmh. Exp.3. Strawberry (Fragaria L.) seedlings were used (n=5 plants/treatment). Treatment system was O (120ppb), F(10μM), O+F, F+M, O+M and C. The treatment period was 90days and [AOT 40]=86.4ppmh. Ecophysiological variables examined were photosynthesis rate measured at saturated irradiance (Amax), stomatal conductance to water vapour (gs), internal CO2 concentration (Ci), photochemical efficiency of PS2 in the dark (Fv/Fm), chlorophyll contents, visual symptom assessment and elemental composition in the leaves. [Results and Discussion] The P+O and O treatments caused a large decrease in Amax values of eggplant and common bean leaves and the P treatment made a little decrease in the Amax . Other parameters those were reduced by the O+P, O and P treatments were gs, Fv/Fm, Chlorophyll contents, and elemental composition. The F treatment made more decrease in Amax, gs and chlorophyll contents in eggplant leaves than those in the P treatment. The O treatment significantly decreased Amax, gs, Fv/Fm and chlorophyll contents in the Exp. 3. From the results mentioned above, it was concluded that phenanthrene and fluoranthene deposited onto leaves, combined with ozone fumigations, negatively affected growth and quality of plants. In addition, all plants fumigated with O, P, F, O+P and O+F showed severe visible symptoms on the foliage during the exposure period. We also note that mannitol, a reactive oxygen scavenger, mitigated negative effects of the F+O, O, P and F on plants and therefore mannitol could be useful for protection of plant from air pollutants. (1) Huang X, Lorelei F, Dixon D, Greenberg B (1996) Ecotoxicology and Environmental Safety, Volume 35 (2), 101-197.

Trade-offs between light interception and leaf water shedding: a comparison of shade- and sun-adapted species in a subtropical rainforest.

PubMed

Meng, Fengqun; Cao, Rui; Yang, Dongmei; Niklas, Karl J; Sun, Shucun

2014-01-01

Species in high-rainfall regions have two major alternative approaches to quickly drain off water, i.e., increasing leaf inclination angles relative to the horizontal plane, or developing long leaf drip tips. We hypothesized that shade-adapted species will have more pronounced leaf drip tips but not greater inclination angles (which can reduce the ability to intercept light) compared to sun-adapted species and that length of leaf drip tips will be negatively correlated with photosynthetic capacity [characterized by light-saturated net photosynthetic rates (Amax), associated light compensation points (LCP), and light saturation points (LSP)]. We tested this hypothesis by measuring morphological and physiological traits that are associated with light-interception and water shedding for seven shade-adapted shrub species, ten sun-adapted understory shrub species, and 15 sun-adapted tree species in a subtropical Chinese rainforest, where mean annual precipitation is around 1,600 mm. Shade-adapted understory species had lower LMA, Amax, LSP, and LCP compared to understory or canopy sun-adapted species; their leaf and twig inclination angles were significantly smaller and leaf drip tips were significantly longer than those in sun-adapted species. This suggests that shade-adapted understory species tend to develop pronounced leaf drip tips but not large leaf inclination angles to shed water. The length of leaf drip tips was negatively correlated with leaf inclination angles and photosynthetic capacity. These relationships were consistent between ordinary regression and phylogenetic generalized least squares analyses. Our study illustrates the trade-offs between light interception and leaf water shedding and indicates that length of leaf drip tips can be used as an indicator of adaptation to shady conditions and overall photosynthetic performance of shrub species in subtropical rainforests.

Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression†

PubMed Central

Tao, Yong-guang; Xu, Yong; Xu, H. Eric; Simons, S. Stoney

2009-01-01

The transcriptional activity of steroid hormones is intimately associated with their structure. Deacylcortivazol (DAC) contains several features that were predicted to make it an inactive glucocorticoid. Nevertheless, gene induction and repression by complexes of glucocorticoid receptor (GR) with DAC occurs with greater potency (lower EC50) than, and equal efficacy (maximal activity, or Amax) to, the very active and smaller synthetic glucocorticoid dexamethasone (Dex). Guided by a recent x-ray structure of DAC bound to the GR ligand binding domain (LBD), we now report that several point mutants in the LBD have little effect on the binding of either agonist steroid. However, these same mutations dramatically alter the Amax and/or EC50 of exogenous and endogenous genes in a manner that depends on steroid structure. In some cases, Dex is no longer a full agonist. These properties appear to result from a preferential inactivation of the AF2 activation domain in the GR LBD of Dex-, but not DAC-, bound receptors. The Dex-bound receptors display normal binding to, but greatly reduced response to, the coactivator TIF2, thus indicating a defect in the transmission efficiency of GR-steroid complex information to the coactivator TIF2. In addition, all GR mutants that are active in gene induction with either Dex or DAC have greatly reduced activity in gene repression. This contrasts with the reports of GR mutations preferentially suppressing GR-mediated induction. The properties of these GR mutants in gene induction support the hypothesis that the Amax and EC50 of GR-controlled gene expression can be independently modified, indicate that the receptor can be modified to favor activity with a specific agonist steroid, and suggest that new ligands with suitable substituents may be able to affect the same LBD conformational changes and thereby broaden the therapeutic applications of glucocorticoid steroids PMID:18578507

[Effects of simulating acid rain on photosynthesis and chlorophyll fluorescence parameters of Quercus glauca Quercus glauca].

PubMed

Wang, Sai; Yi, Li-Ta; Yu, Shu-Quan; Zhang, Chao; Shi, Jing-Jing

2014-08-01

At three levels of simulated acid rainfall intensities with pH values of 2.5 (severe), 40 (medium) and 5.6 (light) respectively, the responses of chlorophyll fluorescence and photosynthetic parameters of Quercus glauca seedlings were studied in three acid rainfall treatments, i. e. only the aboveground of seedlings exposed to acid rain (T1), both of the seedlings and soil exposed to acid rain (T2), only the soil exposed to acid rain (T3) compared with blank control (CK). Under the severe acid rainfall, T1 significantly inhibited chlorophyll synthesis, and thus reduced the primary photochemical efficiency of PS II ( F(v)/F(m)), potential activity of PS II (F(v)/F(o)) , apparent quantum (Y), net photosynthetic rate (P(n)), and transpiration rate (T(r)), but increased the light compensation point (LCP) and dark respiration rate (R(d)) of Q. glauca seedlings. T2 inhibited, but T3 played a little enhancement on the aforementioned parameters of Q. glauca seedlings. Under the conditions of medium and light acid rainfall intensities, the above parameters in the three treatments were higher than that of CK, except with lower R(d). The chlorophyll fluorescence and photosynthetic parameters showed a similar tendency in the three treatments, i. e. T2>T3 >T1. It indicated that T1 had the strongest inhibition on seedlings in condition of the severe acid rainfall, while T2 had the most dramatic facilitating effect on seedlings under the medium and light acid rainfall. Intensity of acid rainfall had significant influences on SPAD, F(v)/F(m), F(v)/F(o), Y, P(n), T(r), and maximum photosynthetic rate (A(max)), whereas treatments of acid rainfall affected SPAD, F(v)/F(m), Y, P(n), T(r), A(max) and light saturation point (LSP). The interaction of acid rainfall intensities and treatments played significant effects on SPAD, F(v)/F(m), Y, P(n) and A(max).

Radicals and Aerosols in the Troposphere and Lower Stratosphere

NASA Astrophysics Data System (ADS)

Volkamer, Rainer; Koenig, Theodore; Dix, Barbara

2016-06-01

The remote tropical free troposphere (FT) is one of the most relevant atmospheric environments on Earth. About 75% of the global tropospheric O3 and CH4 loss occurs at tropical latitudes. Tropospheric bromine and iodine catalytically destroy tropospheric O3, oxidize atmospheric mercury, and modify oxidative capacity, and aerosols. Oxygenated VOCs (OVOC) modify HOx (= OH + HO2), NOx (= NO + NO2), tropospheric O3, aerosols, and are a sink for BrOx (= Br + BrO). Until recently, atmospheric models were untested for lack of vertically resolved measurements of BrO and IO radicals in the tropical troposphere. BrO and IO are highly reactive trace gases. Even very low concentrations (parts per trillion; 1 pptv = 10-12 volume mixing ratio) can significantly modify the lifetime of climate active gases, and determine (bromine) the rate limiting step of mercury oxidation in air (that is washed out, and subsequently bio-accumulates in fish). Analytical challenges arise when these radicals modify in sampling lines. Sensitive yet robust, portable, and inherently calibrated measurements directly in the open atmosphere have recently been demonstrated by means of limb-measurements of scattered solar photons by the University of Colorado Airborne Multi-AXis DOAS instrument (CU AMAX-DOAS) from research aircraft. The CU AMAX-DOAS instrument is optimized to (1) locate BrO, IO and glyoxal (a short lived OVOC) in the troposphere, (2) decouple stratospheric absorbers, (3) maximize sensitivity at instrument altitude, (4) facilitate altitude control and (5) enable observations over a wide range of solar zenith angles. Further, (6) the filling-in of Fraunhofer lines (Ring-effect) by Raman Scattering offers interesting opportunities for radiative closure studies to assess the effects of aerosols on Climate.

Predicting tropical plant physiology from leaf and canopy spectroscopy

NASA Astrophysics Data System (ADS)

Doughty, C.; Asner, G. P.; Martin, R.

2009-12-01

A broad understanding of tropical forest leaf photosynthesis has long been a goal for tropical forest ecologists, but elusive, due to difficult canopy access and great species diversity. In this paper, we develop an empirical model to predict light saturated sunlit tropical leaf photosynthesis based on leaf and canopy spectra with the goal of developing a high resolution remote sensing technique to measure canopy photosynthesis. To develop this model, we used the partial least squares (PLS) regression technique on three tropical forest datasets (~168 species), two in Hawaii and one in the tropical rainforest module of Biosphere 2 (B2L). For each species, we measured light saturated photosynthesis (A), light and CO2 saturated photosynthesis (Amax), day respiration (R), leaf spectra (400-2500 nm with 1 nm sampling), leaf nitrogen (N), chlorophyll A and B, carotenoids, and specific leaf area (SLA). On a subset of species we measured Jmax and Vcmax based on light and Aci curves. The model best predicted A (r2 = 0.74, root mean square error (RMSE) = 2.85 µmol m-2 s-1), R (r2 of 0.48, RMSE of -0.52 µmol m-2 s-1) followed by Amax (r2 of 0.47, RMSE of 5.1 µmol m-2 s-1), Jmax, (R2 = 0.52, RMSE = 39) and VCmax (R2 = 0.39, RMSE = 36). The PLS weightings, which indicate which wavelengths most contribute to the model, indicated that physiology weightings were most similar to nitrogen weightings, followed by chlorophyll and SLA. We combined leaf-level reflectance and transmittance with a canopy radiative transfer model to simulate top-of-canopy reflectance, and found that canopy spectra are a better predictor of light saturated photosynthesis more strongly (RMSE = 2.4 µmol m-2 s-1) than are leaf spectra (RMSE = 2.85 µmol m-2 s-1). The results suggest that there is potential for this technique to be used with high fidelity imaging spectrometers to remotely sense tropical forest canopy photosynthesis.

High-throughput multiple-mouse imaging with micro-PET/CT for whole-skeleton assessment.

PubMed

Yagi, Masashi; Arentsen, Luke; Shanley, Ryan M; Hui, Susanta K

2014-11-01

Recent studies have proven that skeleton-wide functional assessment is essential to comprehensively understand physiological aspects of the skeletal system. Therefore, in contrast to regional imaging studies utilizing a multiple-animal holder (mouse hotel), we attempted to develop and characterize a multiple-mouse imaging system with micro-PET/CT for high-throughput whole-skeleton assessment. Using items found in a laboratory, a simple mouse hotel that houses four mice linked with gas anesthesia was constructed. A mouse-simulating phantom was used to measure uniformity in a cross sectional area and flatness (Amax/Amin*100) along the axial, radial and tangential directions, where Amax and Amin are maximum and minimum activity concentration in the profile, respectively. Fourteen mice were used for single- or multiple-micro-PET/CT scans. NaF uptake was measured at eight skeletal sites (skull to tibia). Skeletal (18)F activities measured with mice in the mouse hotel were within 1.6 ± 4% (mean ± standard deviation) of those measured with mice in the single-mouse holder. Single-holder scanning yields slightly better uniformity and flatness over the hotel. Compared to use of the single-mouse holder, scanning with the mouse hotel reduced study time (by 65%), decreased the number of scans (four-fold), reduced cost, required less computer storage space (40%), and maximized (18)F usage. The mouse hotel allows high-throughput, quantitatively equivalent scanning compared to the single-mouse holder for micro-PET/CT imaging for whole-skeleton assessment of mice. Copyright © 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Photosynthesis and xanthophyll cycle-mediated photoprotection in leaves of Quercus rubra and Q. alba seedlings of different light environments

Treesearch

Shi-Jean S. Sung; Dianpeng Xu; Paul P. Kormanik; Clanton C. Black

1997-01-01

Two and three years after the outplanting of 1-0 northern red oak (Quercus rubra, NRO) and white oak (Q. alba, WO) nursery stocks, the highest net photosynthetic rates (Amax) were observed from seedlings growing on a clearcut site, followed by those under a pine stand. Both NRO and WO...

Adsorption and fractionation of a muck fulvic acid on kaolinite and goethite at pH 3.7,6, and 8

USGS Publications Warehouse

Namjesnik-Dejanovic, K.; Maurice, P.A.; Aiken, G.R.; Cabaniss, S.; Chin, Y.-P.; Pullin, M.J.

2000-01-01

Molecular weight (MW) of humic materials is a key factor controlling proton and metal binding and organic pollutant partitioning. Several studies have suggested preferential adsorption of higher MW, more aromatic moieties to mineral surfaces; quantification of such processes is fundamental to development of predictive models. We used high pressure size exclusion chromatography (HPSEC) to quantify MW changes upon adsorption of a muck fulvic acid (MFA) extracted from a peat deposit to kaolinite and goethite, at pH 3.7,6, and 8 at 22 ??C, I = 0.01 (NaC1), 24-h reaction time. MFA adsorption affinity was greater for goethite than for kaolinite. At concentrations less than the adsorption maximum (A(max)) for both adsorbents, the weight-average MW (M(w)) of MFA remaining in solution decreased by as much as several hundred Daltons relative to control samples, indicating preferential adsorption of the higher MW components. At concentrations more than A(max), M(w) of MFA in solution did not change appreciably. Although total adsorption decreased significantly as pH increased, fractionation as measured by change in M(w) remained similar, perhaps indicating greater selectivity for higher MW components at higher pH. Absorptivities at ?? = 280 nm normalized to mg C L-1 (??) suggested preferential adsorption of more aromatic moieties to kaolinite. ?? could not be used for goethite-reacted samples because high Fe concentrations in the aqueous phase brought about by goethite dissolution interfered with the spectroscopic analysis. Preliminary kinetic experiments suggested that smaller molecules adsorbed first and were replaced by larger molecules whose adsorption was thermodynamically favored.

Dollar Summary of Prime Contract Awards by State, Place, and Contractor, FY84, Part 3, (Anderson, Indiana-Winona, Mississippi).

DTIC Science & Technology

1984-01-01

ALMONT ALMONT WELDING WORKS INC 102 102 ALPENA FLETCHER MOTEL 27 27 HARRYS OIL CO 65 65 HOMANT OIL CO 117 117 KOSS INDUSTRIES INC 538 538 PARSONS G S...COMPANY 108 Joe XEROX CORPORATION 59 59 ZOLNIEREK DAVID J INC 43 43 TOTAL - ALPENA 957 667 290 ANN ARBOR ADVERTEL COMMUNICATION INC 60 AMAX MATERIALS

Effects of rainfall exclusion on leaf gas exchange traits and osmotic adjustment in mature canopy trees of Dryobalanops aromatica (Dipterocarpaceae) in a Malaysian tropical rain forest.

PubMed

Inoue, Yuta; Ichie, Tomoaki; Kenzo, Tanaka; Yoneyama, Aogu; Kumagai, Tomo'omi; Nakashizuka, Tohru

2017-10-01

Climate change exposes vegetation to unusual levels of drought, risking a decline in productivity and an increase in mortality. It still remains unclear how trees and forests respond to such unusual drought, particularly Southeast Asian tropical rain forests. To understand leaf ecophysiological responses of tropical rain forest trees to soil drying, a rainfall exclusion experiment was conducted on mature canopy trees of Dryobalanops aromatica Gaertn.f. (Dipterocarpaceae) for 4 months in an aseasonal tropical rain forest in Sarawak, Malaysia. The rainfall was intercepted by using a soft vinyl chloride sheet. We compared the three control and three treatment trees with respect to leaf water use at the top of the crown, including stomatal conductance (gsmax), photosynthesis (Amax), leaf water potential (predawn: Ψpre; midday: Ψmid), leaf water potential at turgor loss point (πtlp), osmotic potential at full turgor (π100) and a bulk modulus of elasticity (ε). Measurements were taken using tree-tower and canopy-crane systems. During the experiment, the treatment trees suffered drought stress without evidence of canopy dieback in comparison with the control trees; e.g., Ψpre and Ψmid decreased with soil drying. Minimum values of Ψmid in the treatment trees decreased during the experiment, and were lower than πtlp in the control trees. However, the treatment trees also decreased their πtlp by osmotic adjustment, and the values were lower than the minimum values of their Ψmid. In addition, the treatment trees maintained gs and Amax especially in the morning, though at midday, values decreased to half those of the control trees. Decreasing leaf water potential by osmotic adjustment to maintain gs and Amax under soil drying in treatment trees was considered to represent anisohydric behavior. These results suggest that D. aromatica may have high leaf adaptability to drought by regulating leaf water consumption and maintaining turgor pressure to improve its leaf water relations. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Near-infrared scattering as a dust diagnostic

NASA Astrophysics Data System (ADS)

Saajasto, Mika; Juvela, Mika; Malinen, Johanna

2018-06-01

Context. Regarding the evolution of dust grains from diffuse regions of space to dense molecular cloud cores, many questions remain open. Scattering at near-infrared wavelengths, or "cloudshine", can provide information on cloud structure, dust properties, and the radiation field that is complementary to mid-infrared "coreshine" and observations of dust emission at longer wavelengths. Aims: We examine the possibility of using near-infrared scattering to constrain the local radiation field and the dust properties, the scattering and absorption efficiency, the size distribution of the grains, and the maximum grain size. Methods: We use radiative transfer modelling to examine the constraints provided by the J, H, and K bands in combination with mid-infrared surface brightness at 3.6 μm. We use spherical one-dimensional and elliptical three-dimensional cloud models to study the observable effects of different grain size distributions with varying absorption and scattering properties. As an example, we analyse observations of a molecular cloud in Taurus, TMC-1N. Results: The observed surface brightness ratios of the bands change when the dust properties are changed. However, even a change of ±10% in the surface brightness of one band changes the estimated power-law exponent of the size distribution γ by up to 30% and the estimated strength of the radiation field KISRF by up to 60%. The maximum grain size Amax and γ are always strongly anti-correlated. For example, overestimating the surface brightness by 10% changes the estimated radiation field strength by 20% and the exponent of the size distribution by 15%. The analysis of our synthetic observations indicates that the relative uncertainty of the parameter distributions are on average Amax, γ 25%, and the deviation between the estimated and correct values ΔQ < 15%. For the TMC-1N observations, a maximum grain size Amax > 1.5μm and a size distribution with γ > 4.0 have high probability. The mass weighted average grain size is ⟨am⟩ = 0.113μm. Conclusions: We show that scattered infrared light can be used to derive meaningful limits for the dust parameters. However, errors in the surface brightness data can result in considerable uncertainties on the derived parameters.

Impact of Climate Change on high and low flows across Great Britain: a temporal analysis and uncertainty assessment.

NASA Astrophysics Data System (ADS)

Beevers, Lindsay; Collet, Lila

2017-04-01

Over the past decade there have been significant challenges to water management posed by both floods and droughts. In the UK, since 2000 flooding has caused over £5Bn worth of damage, and direct costs from the recent drought (2011-12) are estimated to be between £70-165M, arising from impacts on public and industrial water supply. Projections of future climate change suggest an increase in temperature and precipitation trends which may exacerbate the frequency and severity of such hazards, but there is significant uncertainty associated with these projections. It thus becomes urgent to assess the possible impact of these changes on extreme flows and evaluate the uncertainties related to these projections, particularly changes in the seasonality of such hazards. This paper aims to assess the changes in seasonality of peak and low flows across Great Britain as a result of climate change. It is based on the Future Flow database; an 11-member ensemble of transient river flow projections from January 1951 to December 2098. We analyse the daily river flow over the baseline (1961-1990) and the 2080s (2069-2098) for 281 gauging stations. For each ensemble member, annual maxima (AMAX) and minima (AMIN) are extracted for both time periods for each gauging station. The month of the year the AMAX and AMIN occur respectively are recorded for each of the 30 years in the past and the future time periods. The uncertainty of the AMAX and AMIN occurrence temporally (monthly) is assessed across the 11 ensemble members, as well as the changes to this temporal signal between the baseline and the 2080s. Ultimately, this work gives a national picture (spatially) of high and low flows occurrence temporally and allows the assessment of possible changes in hydrological dynamics as a result of climate change in a statistical framework. Results will quantify the uncertainty related to the Climate Model parameters which are cascaded into the modelling chain. This study highlights the issues facing hydrological cycle management, due to changing spatial and temporal trends in order to anticipate and adapt to hydro-hazard changes in an uncertain context.

Differences in the Photosynthetic Activity of C3 and C4 Graminoids in Short-Hydroperiod Marl Prairies of the Florida Everglades: Responses to Seasonality and Water Management

NASA Astrophysics Data System (ADS)

Oberbauer, S. F.; Olivas, P. C.; Schedlbauer, J. L.; Moser, J.

2011-12-01

Short hydroperiod marsh of the Everglades is dominated by a mix of sawgrass (Cladium jamaicense, a C3 sedge) and Muhly grass (Muhlenbergia capillaris, a C4 grass). Although the Everglades are located in a subtropical region, the climate is classified as tropical with distinct annual rainy and dry seasons during the summer and winter, respectively. Water levels in marl prairies vary greatly over the year driven by seasonality of rainfall, but are modified strongly by water management practices. As a result, the rainy season and period of inundation generally do not completely coincide. Water tables fall as much as 80 cm below the surface for approximately 6-7 months starting about December/January and reach up to 40 cm above the surface during the inundation period. Eddy covariance studies from this habitat revealed strong reductions in CO2 uptake coinciding with water tables inundating the surface. Submersion of macrophyte leaf area accounts for some of the reduction. To test if changes in leaf physiology also contribute to this reduced ecosystem CO2 uptake, we measured maximum assimilation rates (Amax) of the dominant species during both seasons in the marsh and on a nearby levee that remains above water. Typical of C4 plants, Amax of Muhlenbergia were high, > 20 μmol m-2 s-1, during the dry season. However when plant crowns were submerged, photosynthetic rates of emergent leaves of Muhlenbergia were strongly reduced to near compensation in some cases. In contrast, Amax of Muhlenbergia measured from higher terrain within 30 m of the flooded sites maintained high rates. Rates of Cladium were lower overall but did not show strong seasonality at either site. This wetland represents an unusual situation in which one of the codominants is effectively photosynthetically inactive during wet season. Planned changes to increase water flow to the Everglades and predicted changes in rainfall with climate change will strongly affect the carbon balance of this habitat.

Responses of Picea mariana to elevated CO2 concentration during growth, cold hardening and dehardening: phenology, cold tolerance, photosynthesis and growth.

PubMed

Bigras, F J; Bertrand, A

2006-07-01

Seedlings from a northern and a southern provenance of black spruce (Picea mariana Mill. BSP) from eastern Canada were exposed to 37 or 71 Pa of carbon dioxide (CO2) during growth, cold hardening and dehardening in a greenhouse. Bud phenology, cold tolerance and photosynthetic efficiency were assessed during the growing and over-wintering periods. Bud set occurred earlier in elevated [CO2] than in ambient [CO2], but it was later in the southern provenance than in the northern provenance. An increase in seedling cold tolerance in early fall was related to early bud set in elevated [CO2]. Maximal photosystem II (PSII) photochemical efficiency (F(v)/F(m)), effective quantum yield (phi(PSII)), photochemical quenching (q(P)), light-saturated photosynthesis (Amax), apparent quantum efficiency (alpha'), light-saturated rate of carboxylation (Vcmax) and electron transport (Jmax) decreased during hardening and recovered during dehardening. Although Amax and alpha' were higher in elevated [CO2] when measured at the growth [CO2], down-regulation of photosynthesis occurred in elevated [CO2] as shown by lower F(v)/F(m), phi(PSII), Vcmax and Jmax. Elevated [CO2] reduced gene expression of the small subunit of Rubisco and also decreased chlorophyll a/chlorophyll b ratio and nitrogen concentration in needles, confirming our observation of down-regulation of photosynthesis. Elevated [CO2] increased the CO2 diffusion gradient and decreased photorespiration, which may have contributed to enhance Amax despite down-regulation of photosynthesis. Total seedling dry mass was higher in elevated [CO2] than in ambient [CO2] at the end of the growing season. However, because of earlier bud formation and cold hardening, and down-regulation of photosynthesis during fall and winter in elevated [CO2], the treatment difference in dry mass increment was less by the end of the winter than during the growing season. Differences in photosynthetic rate observed during fall, winter and spring account for the inter-annual variations in carbon assimilation of black spruce seedlings: our results demonstrate that these variations need to be considered in carbon budget studies.

Partitioning the components of maxillary tooth displacement by the comparison of data from three cephalometric superimpositions.

PubMed

Baumrind, S; Ben-Bassat, Y; Bravo, L A; Curry, S; Korn, E L

1996-01-01

Using roentgenographic cephalograms from a sample of subjects with metallic implants, appropriately superimposed tracings were used to distinguish developmental and treatment-associated displacements of the maxillary central incisor and first molar associated "local" changes within the periodontium from "secondary" changes which reflect sutural and appositional growth at more distant osseous loci. Tracings were superimposed on anterior cranial base (ACB), on the maxillary implants only (IMP_MAX), and according to the best fit of maxillary anatomic structures without reference to the implants (A_MAX). Using the IMP_MAX superimposition, one could measure total local displacement at any landmark taking into consideration the effects of all appositional and resorptive changes on the superior and anterior surfaces of the palate, whereas using the A_MAX superimposition one could measure local displacement without consideration of surface appositional and resorptive changes. If the second of these measurements were subtracted from the first, the result would be a direct measurement of the effects of surface appositional and resorptive changes as they are expressed at that particular landmark. This strategy has enabled us to quantify and report the amount of accommodation which occurs at the location of each dental landmark in association with the resorptive and appositional changes which occur through time on the superior and anterior surfaces of the hard palate.

Music as an auditory stimulus in stroke patients.

PubMed

Antić, Sonja; Galinović, Ivana; Lovrendić-Huzjan, Arijana; Vuković, Vlasta; Jurasić, Miljenka-Jelena; Demarin, Vida

2008-01-01

Auditory stimulation increases mean blood flow velocity (MBFV) in the middle cerebral artery (MCA) in healthy individuals. Our aim was to monitor such changes in the affected MCA of patients with acute ischemic stroke (AIS). The study included 66 non-thrombolysed patients with AIS who were divided into groups according to National Institutes of Health Stroke Scale (NIHSS) score. Group I consisted of patients with NIHSS score 10 and group II with NIHSS score > or =11. Affected MCA was insonated with transcranial Doppler (TCD). MCA MBFVs were monitored during listening to music for 30 minutes. The first response of MBFV increase was measured as time (Tmax) and percentage of amplitude change (Amax). Pearson Chi-Square test was used. In 78.85% of patients there was a significant increase in MBFV compared to baseline values as a reaction to the music. There was no significant difference in Tmax or Amax between the two groups. However, a trend of longer Tmax was observed with every 2 NIHSS score increase. Music is an auditory stimulus in stroke patients and can be measured with TCD as MCA MBFV increase. Although our study showed no significant change of reaction time with the severity of stroke, a trend of prolonged Tmax was observed with NIHSS score increase.

[Characterization of polygalacturonase covalently bonded to Sepharose].

PubMed

Bock, W; Krause, M; Anger, H; Flemming, C

1981-01-01

For the soluble endo-polygalacturonase (EC 3.2.1.15.) from Aspergillus spec., investigated in the present work, the defined substrate turnover U at 50% loss of viscosity if 0.2% and is independent on the reaction temperature. In the case of the covalently-bonded enzyme, the following linear equation applies to U, depending on the specific activity A and in the limits from A = O [U] and Amax: U = [U] + S square root of A. U is influenced by the kind of linkage, the conditions of immobilization and the properties of the carrier: it is a measure of the postulated conformational change of the polygalacturonase. The characteristic limiting value for the substrate turnover at A = O [U] is also temperature-independent and proves to be a true increment of binding, whereas Amax depends essentially on the porosity of the carrier. Polygalacturonase-sepharose complexes with a real substrate turnover U of 3--20% were prepared by varying systematically the kind of linkage and the specific activity A. It was found that with increasing U these complexes were, as a rule, inhibited to a lesser extent by a non-competitive pectinase inhibitor than the soluble polygalacturonase. Furthermore, their ability to liberate or enrich oligomeric galacturonic acids with a degree of polymerization greater than 3 was markedly reduced.

Relationships of leaf dark respiration to leaf nitrogen, specific leaf area and leaf life-span: a test across biomes and functional groups

Treesearch

Peter B. Reich; Michael B. Walters; David S. Ellsworth; [and others; [Editor’s note: James M.. Vose is the SRS co-author for this publication.

1998-01-01

Based on prior evidence of coordinated multiple leaf trait scaling, the authors hypothesized that variation among species in leaf dark respiration rate (Rd) should scale with variation in traits such as leaf nitrogen (N), leaf life-span, specific leaf area (SLA), and net photosynthetic capacity (Amax). However, it is not known whether such scaling, if it exists, is...

Machine learning modelling for predicting soil liquefaction susceptibility

NASA Astrophysics Data System (ADS)

Samui, P.; Sitharam, T. G.

2011-01-01

This study describes two machine learning techniques applied to predict liquefaction susceptibility of soil based on the standard penetration test (SPT) data from the 1999 Chi-Chi, Taiwan earthquake. The first machine learning technique which uses Artificial Neural Network (ANN) based on multi-layer perceptions (MLP) that are trained with Levenberg-Marquardt backpropagation algorithm. The second machine learning technique uses the Support Vector machine (SVM) that is firmly based on the theory of statistical learning theory, uses classification technique. ANN and SVM have been developed to predict liquefaction susceptibility using corrected SPT [(N1)60] and cyclic stress ratio (CSR). Further, an attempt has been made to simplify the models, requiring only the two parameters [(N1)60 and peck ground acceleration (amax/g)], for the prediction of liquefaction susceptibility. The developed ANN and SVM models have also been applied to different case histories available globally. The paper also highlights the capability of the SVM over the ANN models.

Uncertainties in evaluation of hazard and seismic risk

NASA Astrophysics Data System (ADS)

Marmureanu, Gheorghe; Marmureanu, Alexandru; Ortanza Cioflan, Carmen; Manea, Elena-Florinela

2015-04-01

Two methods are commonly used for seismic hazard assessment: probabilistic (PSHA) and deterministic(DSHA) seismic hazard analysis.Selection of a ground motion for engineering design requires a clear understanding of seismic hazard and risk among stakeholders, seismologists and engineers. What is wrong with traditional PSHA or DSHA ? PSHA common used in engineering is using four assumptions developed by Cornell in 1968:(1)-Constant-in-time average occurrence rate of earthquakes; (2)-Single point source; (3).Variability of ground motion at a site is independent;(4)-Poisson(or "memory - less") behavior of earthquake occurrences. It is a probabilistic method and "when the causality dies, its place is taken by probability, prestigious term meant to define the inability of us to predict the course of nature"(Nils Bohr). DSHA method was used for the original design of Fukushima Daichii, but Japanese authorities moved to probabilistic assessment methods and the probability of exceeding of the design basis acceleration was expected to be 10-4-10-6 . It was exceeded and it was a violation of the principles of deterministic hazard analysis (ignoring historical events)(Klügel,J,U, EGU,2014, ISSO). PSHA was developed from mathematical statistics and is not based on earthquake science(invalid physical models- point source and Poisson distribution; invalid mathematics; misinterpretation of annual probability of exceeding or return period etc.) and become a pure numerical "creation" (Wang, PAGEOPH.168(2011),11-25). An uncertainty which is a key component for seismic hazard assessment including both PSHA and DSHA is the ground motion attenuation relationship or the so-called ground motion prediction equation (GMPE) which describes a relationship between a ground motion parameter (i.e., PGA,MMI etc.), earthquake magnitude M, source to site distance R, and an uncertainty. So far, no one is taking into consideration strong nonlinear behavior of soils during of strong earthquakes. But, how many cities, villages, metropolitan areas etc. in seismic regions are constructed on rock? Most of them are located on soil deposits? A soil is of basic type sand or gravel (termed coarse soils), silt or clay (termed fine soils) etc. The effect on nonlinearity is very large. For example, if we maintain the same spectral amplification factor (SAF=5.8942) as for relatively strong earthquake on May 3,1990(MW=6.4),then at Bacǎu seismic station for Vrancea earthquake on May 30,1990 (MW =6.9) the peak acceleration has to be a*max =0.154g and the actual recorded was only, amax =0.135g(-14.16%). Also, for Vrancea earthquake on August 30,1986(MW=7.1),the peak acceleration has to be a*max = 0.107g instead of real value recorded of 0.0736 g(- 45.57%). There are many data for more than 60 seismic stations. There is a strong nonlinear dependence of SAF with earthquake magnitude in each site. The authors are coming with an alternative approach called "real spectral amplification factors" instead of GMPE for all extra-Carpathian area where all cities and villages are located on soil deposits. Key words: Probabilistic Seismic Hazard; Uncertainties; Nonlinear seismology; Spectral amplification factors(SAF).

Within-twig leaf distribution patterns differ among plant life-forms in a subtropical Chinese forest.

PubMed

Meng, Fengqun; Cao, Rui; Yang, Dongmei; Niklas, Karl J; Sun, Shucun

2013-07-01

In theory, plants can alter the distribution of leaves along the lengths of their twigs (i.e., within-twig leaf distribution patterns) to optimize light interception in the context of the architectures of their leaves, branches and canopies. We hypothesized that (i) among canopy tree species sharing similar light environments, deciduous trees will have more evenly spaced within-twig leaf distribution patterns compared with evergreen trees (because deciduous species tend to higher metabolic demands than evergreen species and hence require more light), and that (ii) shade-adapted evergreen species will have more evenly spaced patterns compared with sun-adapted evergreen ones (because shade-adapted species are generally light-limited). We tested these hypotheses by measuring morphological traits (i.e., internode length, leaf area, lamina mass per area, LMA; and leaf and twig inclination angles to the horizontal) and physiological traits (i.e., light-saturated net photosynthetic rates, Amax; light saturation points, LSP; and light compensation points, LCP), and calculated the 'evenness' of within-twig leaf distribution patterns as the coefficient of variation (CV; the higher the CV, the less evenly spaced leaves) of within-twig internode length for 9 deciduous canopy tree species, 15 evergreen canopy tree species, 8 shade-adapted evergreen shrub species and 12 sun-adapted evergreen shrub species in a subtropical broad-leaved rainforest in eastern China. Coefficient of variation was positively correlated with large LMA and large leaf and twig inclination angles, which collectively specify a typical trait combination adaptive to low light interception, as indicated by both ordinary regression and phylogenetic generalized least squares analyses. These relationships were also valid within the evergreen tree species group (which had the largest sample size). Consistent with our hypothesis, in the canopy layer, deciduous species (which were characterized by high LCP, LSP and Amax) had more even leaf distribution patterns than evergreen species (which had low LCP, LSP and Amax); shade-adapted evergreen species had more even leaf distribution patterns than sun-adapted evergreen species. We propose that the leaf distribution pattern (i.e., 'evenness' CV, which is an easily measured functional trait) can be used to distinguish among life-forms in communities similar to the one examined in this study.

Effect of Methamphetamine on Spectral Binding, Ligand Docking and Metabolism of Anti-HIV Drugs with CYP3A4

PubMed Central

Ande, Anusha; Wang, Lei; Vaidya, Naveen K.; Li, Weihua; Kumar, Santosh; Kumar, Anil

2016-01-01

Cytochrome P450 3A4 (CYP3A4) is the major drug metabolic enzyme, and is involved in the metabolism of antiretroviral drugs, especially protease inhibitors (PIs). This study was undertaken to examine the effect of methamphetamine on the binding and metabolism of PIs with CYP3A4. We showed that methamphetamine exhibits a type I spectral change upon binding to CYP3A4 with δAmax and KD of 0.016±0.001 and 204±18 μM, respectively. Methamphetamine-CYP3A4 docking showed that methamphetamine binds to the heme of CYP3A4 in two modes, both leading to N-demethylation. We then studied the effect of methamphetamine binding on PIs with CYP3A4. Our results showed that methamphetamine alters spectral binding of nelfinavir but not the other type I PIs (lopinavir, atazanavir, tipranavir). The change in spectral binding for nelfinavir was observed at both δAmax (0.004±0.0003 vs. 0.0068±0.0001) and KD (1.42±0.36 vs.2.93±0.08 μM) levels. We further tested effect of methamphetamine on binding of 2 type II PIs; ritonavir and indinavir. Our results showed that methamphetamine alters the ritonavir binding to CYP3A4 by decreasing both the δAmax (0.0038±0.0003 vs. 0.0055±0.0003) and KD (0.043±0.0001 vs. 0.065±0.001 nM), while indinavir showed only reduced KD in presence of methamphetamine (0.086±0.01 vs. 0.174±0.03 nM). Furthermore, LC-MS/MS studies in high CYP3A4 human liver microsomes showed a decrease in the formation of hydroxy ritonavir in the presence of methamphetamine. Finally, CYP3A4 docking with lopinavir and ritonavir in the absence and presence of methamphetamine showed that methamphetamine alters the docking of ritonavir, which is consistent with the results obtained from spectral binding and metabolism studies. Overall, our results demonstrated differential effects of methamphetamine on the binding and metabolism of PIs with CYP3A4. These findings have clinical implication in terms of drug dose adjustment of antiretroviral medication, especially with ritonavir-boosted antiretroviral therapy, in HIV-1-infected individuals who abuse methamphetamine. PMID:26741368

Integrating Proteomics and Enzyme Kinetics Reveals Tissue-Specific Types of the Glycolytic and Gluconeogenic Pathways.

PubMed

Wiśniewski, Jacek R; Gizak, Agnieszka; Rakus, Dariusz

2015-08-07

Glycolysis is the core metabolic pathway supplying energy to cells. Whereas the vast majority of studies focus on specific aspects of the process, global analyses characterizing simultaneously all enzymes involved in the process are scarce. Here, we demonstrate that quantitative label- and standard-free proteomics allows accurate determination of titers of metabolic enzymes and enables simultaneous measurements of titers and maximal enzymatic activities (Amax) of all glycolytic enzymes and the gluconeogenic fructose 1,6-bisphosphatase in mouse brain, liver and muscle. Despite occurrence of tissue-specific isoenzymes bearing different kinetic properties, the enzyme titers often correlated well with the Amax values. To provide a more general picture of energy metabolism, we analyzed titers of the enzymes in additional 7 mouse organs and in human cells. Across the analyzed samples, we identified two basic profiles: a "fast glucose uptake" one in brain and heart, and a "gluconeogenic rich" one occurring in liver. In skeletal muscles and other organs, we found intermediate profiles. Obtained data highlighted the glucose-flux-limiting role of hexokinase which activity was always 10- to 100-fold lower than the average activity of all other glycolytic enzymes. A parallel determination of enzyme titers and maximal enzymatic activities allowed determination of kcat values without enzyme purification. Results of our in-depth proteomic analysis of the mouse organs did not support the concepts of regulation of glycolysis by lysine acetylation.

Resting afferent renal nerve discharge and renal inflammation: Elucidating the role of afferent and efferent renal nerves in DOCA-salt hypertension

PubMed Central

Banek, Christopher T.; Knuepfer, Mark M.; Foss, Jason D.; Fiege, Jessica K.; Asirvatham-Jeyaraj, Ninitha; Van Helden, Dusty; Shimizu, Yoji; Osborn, John W.

2016-01-01

Renal sympathetic denervation (RDNx) has emerged as a novel therapy for hypertension; however, the therapeutic mechanisms remain unclear. Efferent renal sympathetic nerve activity (RSNA) has recently been implicated in trafficking renal inflammatory immune cells and inflammatory chemokine and cytokine release. Several of these inflammatory mediators are known to activate or sensitize afferent nerves. This study aimed to elucidate the roles of efferent and afferent renal nerves in renal inflammation and hypertension in the deoxycorticosterone acetate (DOCA)-salt rat model. Uninephrectomized male Sprague Dawley rats (275–300g) underwent selective afferent-selective RDNx (A-RDNx; n=10), total RDNx (T-RDNx; n=10), or Sham (n=10) and were instrumented for measurement of mean arterial pressure (MAP) and heart rate (HR) by radiotelemetry. Rats received 100mg DOCA (s.c.) and 0.9% saline for 21 days. Resting afferent renal nerve activity (ARNA) in DOCA and Vehicle animals was measured after the treatment protocol. Renal tissue inflammation was assessed by renal cytokine content and T-cell infiltration and activation. Resting ARNA, expressed as a percent of peak afferent nerve activity (%Amax), was substantially increased in DOCA vs. Vehicle (35.8±4.4 vs. 15.3±2.8%Amax). The DOCA-Sham hypertension (132±12 mmHg) was attenuated by ~50% in both T-RDNx (111±8) and A-RDNx (117±5mmHg) groups. Renal inflammation induced by DOCA-salt was attenuated by T-RDNx, and unaffected by A-RDNx. These data suggest ARNA may mediate the hypertensive response to DOCA-salt, but inflammation may be mediated primarily by efferent RSNA. Also, resting ARNA is elevated in DOCA-salt rats, which may highlight a crucial neural mechanism in the development and maintenance of hypertension. PMID:27698066

A Digital Signal Processor for Doppler Radar Sensing of Vital Signs

DTIC Science & Technology

2001-10-25

shows a small spike halfway each heartbeat. This is known as the dicrotic notch , which signifies a sudden drop in pressure after systolic contraction...It is caused by a small reflux flow of blood back into the aortic valve and coronary vessels. This dicrotic notch in the heart signal is clipped...signal, and amax was the maximum amplitude of the signal in the specified window. The user could set the factor k, and it determined the threshold at

A Multiple Ranking Procedure Adapted to Discrete-Event Simulation.

DTIC Science & Technology

1983-12-01

stopped if 50% of the original data set has been truncated and the bias effects have still not been eliminated. Use of this limit is reinforced by the... immediately ; thus when the store opens on Monday, the order placed on the preceding Friday has already arrived. Rackorders 103 are permitted. The...INITIALIZE VARIABLES USED DURING C *****EACH PASS THROUGH THE DATA C AMAX = 0.0 CUSUM = 0.0 PMEAN = 0.0 AMIN = 0.0 PSUM = 0.0 M = 0 NEGTIV = 0 POSTIV = 0

Plant water use efficiency over geological time--evolution of leaf stomata configurations affecting plant gas exchange.

PubMed

Assouline, Shmuel; Or, Dani

2013-01-01

Plant gas exchange is a key process shaping global hydrological and carbon cycles and is often characterized by plant water use efficiency (WUE - the ratio of CO2 gain to water vapor loss). Plant fossil record suggests that plant adaptation to changing atmospheric CO2 involved correlated evolution of stomata density (d) and size (s), and related maximal aperture, amax . We interpreted the fossil record of s and d correlated evolution during the Phanerozoic to quantify impacts on gas conductance affecting plant transpiration, E, and CO2 uptake, A, independently, and consequently, on plant WUE. A shift in stomata configuration from large s-low d to small s-high d in response to decreasing atmospheric CO2 resulted in large changes in plant gas exchange characteristics. The relationships between gas conductance, gws , A and E and maximal relative transpiring leaf area, (amax ⋅d), exhibited hysteretic-like behavior. The new WUE trend derived from independent estimates of A and E differs from established WUE-CO2 trends for atmospheric CO2 concentrations exceeding 1,200 ppm. In contrast with a nearly-linear decrease in WUE with decreasing CO2 obtained by standard methods, the newly estimated WUE trend exhibits remarkably stable values for an extended geologic period during which atmospheric CO2 dropped from 3,500 to 1,200 ppm. Pending additional tests, the findings may affect projected impacts of increased atmospheric CO2 on components of the global hydrological cycle.

Decelerations of Parachute Opening Shock in Skydivers.

PubMed

Gladh, Kristofer; Lo Martire, Riccardo; Äng, Björn O; Lindholm, Peter; Nilsson, Jenny; Westman, Anton

2017-02-01

High prevalence of neck pain among skydivers is related to parachute opening shock (POS) exposure, but few investigations of POS deceleration have been made. Existing data incorporate equipment movements, limiting its representability of skydiver deceleration. This study aims to describe POS decelerations and compare human- with equipment-attached data. Wearing two triaxial accelerometers placed on the skydiver (neck-sensor) and equipment (rig-sensor), 20 participants made 2 skydives each. Due to technical issues, data from 35 skydives made by 19 participants were collected. Missing data were replaced using data substitution techniques. Acceleration axes were defined as posterior to anterior (+ax), lateral right (+ay), and caudal to cranial (+az). Deceleration magnitude [amax (G)] and jerks (G · s-1) during POS were analyzed. Two distinct phases related to skydiver positioning and acceleration direction were observed: 1) the x-phase (characterized by -ax, rotating the skydiver); and 2) the z-phase (characterized by +az, skydiver vertically oriented). Compared to the rig-sensor, the neck-sensor yielded lower amax (3.16 G vs. 6.96 G) and jerk (56.3 G · s-1 vs. 149.0 G · s-1) during the x-phase, and lower jerk (27.7 G · s-1 vs. 54.5 G · s-1) during the z-phase. The identified phases during POS should be considered in future neck pain preventive strategies. Accelerometer data differed, suggesting human-placed accelerometry to be more valid for measuring human acceleration.Gladh K, Lo Martire R, Äng BO, Lindholm P, Nilsson J, Westman A. Decelerations of parachute opening shock in skydivers. Aerosp Med Hum Perform. 2017; 88(2):121-127.

A comparative study of oak (Quercus, Fagaceae) seedling physiology during summer drought in southern California.

PubMed

Mahall, Bruce E; Tyler, Claudia M; Cole, E Shelly; Mata, Catarina

2009-04-01

Natural recruitment of oaks appears to be declining throughout the northern hemisphere. Summer drought poses a potentially important barrier to oak recruitment in southern California. To evaluate this barrier, we grew evergreen Quercus agrifolia and deciduous Q. lobata from seeds near parental trees. We measured water relations, chlorophyll fluorescence, and gas exchange during these seedlings' fourth and fifth summers and compared them to neighboring adults. Most seedlings had substantially lower values for predawn xylem pressure potential (Ψ(pd)), minimum photosystem II (PSII) quantum efficiency (Φ(PSIIMIN)), maximum quantum efficiency for PSII under dark-adapted leaf conditions (Fv/Fm), and maximum photosynthetic assimilation (Amax), and higher values for maximum nonphotochemical quenching (NPQmax) than did conspecific adults. The high, unvarying Ψ(pd) values of the adults suggest they use perennially available groundwater. Quercus lobata seedlings commonly had lower values for Ψ(pd) than did Q. agrifolia, and values for Ψ(pd) and Φ(PSIIMIN) were significantly related to size in Q. lobata but not in Q. agrifolia. These data suggest important interspecific differences in root architecture. Lower values for Φ(PSIIMIN), Fv/Fm, and higher NPQmax in Q. agrifolia indicate that Q. agrifolia seedlings were usually under more stress than Q. lobata, which typically had higher Amax rates than did Q. agrifolia seedlings. Diurnal photosynthesis curves were quite flat for Q. agrifolia, but they peaked in the morning for Q. lobata. Established seedlings appeared to be under more stress than adults, but this stress did not appear severe enough to cause death. Access to perennially available groundwater may be crucial for the seedling to sapling transition.

Utilization of lightflecks by seedlings of five dominant tree species of different subtropical forest successional stages under low-light growth conditions.

PubMed

Zhang, Q; Chen, Y J; Song, L Y; Liu, N; Sun, L L; Peng, C L

2012-05-01

We selected five typical tree species, including one early-successional species (ES) Pinus massoniana Lamb., two mid-successional species (MS) Schima superba Gardn. et Champ. and Castanopsis fissa (Champ. ex Benth.) Rehd. et Wils. and two late-successional species (LS) Cryptocarya concinna Hance. and Acmena acuminatissima (BI.) Merr et Perry., which represent the plants at three successional periods in Dinghushan subtropical forest succession of southern China. Potted seedlings of the five species were grown under 12% of full sunlight for 36 months. The ES and MS showed the slowest and fastest responses to lightflecks, respectively, which correlated with the rate of stomatal opening. In contrast to P. massoniana and C. concinna, the other three species exhibited a high induction loss. Early-successional species showed the lowest specific leaf area and chlorophyll content, the highest photosynthetic capacity (A(max)) and respiratory carbon losses (R(d)). Compared with ES and MS, LS showed lower A(max) and R(d). The five tree species showed a similar chlorophyll a/b ratio after long-term low-light adaptations. On the other hand, LS had a relatively higher de-epoxidation state to protect themselves from excess light during lightflecks. Our results indicated that (i) slower responses to lightflecks could partially explain why ES species could not achieve seedling regeneration in low-light conditions; (ii) fast responses to lightflecks could partially explain why MS species could achieve seedling regeneration in low-light conditions; and (iii) smaller respiratory carbon losses might confer on the LS species a competitive advantage in low-light conditions.

The particle size distribution in Saturn's Main Rings from VIMS and UVIS stellar occultations and RSS radio occultations.

NASA Astrophysics Data System (ADS)

Jerousek, R. G.; Colwell, J. E.; Hedman, M. M.; Marouf, E. A.; French, R. G.; Esposito, L. W.; Nicholson, P. D.

2017-12-01

The parameters of a simple power-law particle size distribution can be inferred from measurements of optical depth at multiple wavelengths (Marouf et al. 1982, 1983, Zebker et al. 1985) where the number of particles of radius between a and a+da is given by n(a)da = n0(a/a0)-qda with amin ≤ a ≤ amax. In the C ring and Cassini division where the surface mass density is low, the Toomre critical wavelength for gravitational collapse is comparable to the radii of the largest particles ( 1 m) and the effects of viewing geometry on measured normal optical depth can be ignored. In these regions, we fit optical depths measured by the Visual and Infrared Mapping Spectrometer (VIMS) at λ = 2.9μm, the Ultraviolet Imaging Spectrograph (UVIS) at λ = 0.15μm, and by the Radio Science Subsystem (RSS) at X band (λ = 3.6cm) and Ka band (λ = 9.4mm) to power-law derived optical depths and constrain the power-law parameters at 10km radial resolution. In the A and B rings where the Toomre critical wavelength is much larger than the radii of the largest particles, self-gravity wakes (ephemeral elongated particle aggregates canted to the direction of orbital motion by Keplerian shear) form. Occultations of these ring regions that occur at different viewing geometries measure different normal optical depths. We model and remove the geometric effects on the ring normal optical depth using the self-gravity wake model of Colwell et al. (2006, 2007) and fit wake model derived optical depths to power-law determined optical depths to constrain the parameters of the power-law particle size distribution. We find average values of amin 5 mm in the background C ring, the C ring plateaus, and in the Cassini Division. In the A and B ring and outside the strong density waves triggered by resonances with Janus and Mimas, we find amin 9 mm except in the trans-Encke region were the minimum particle radius drops to 5 mm and again to about 3.5 mm in the trans-Keeler region near the A ring outer edge. amax ranges from one to several meters throughout the main rings, and a positive correlation between amax and the measured optical depth except in the C ring plateaus. Over the various ring regions, average amin and q are consistent with determinations from previous studies by Harbison et al. (2013), Becker et al. (2016), Jerousek et al. (2016), and Marouf et al. (2008a) with average q 2.9-3.1.

Improved fire protection system for underground fueling areas. Volume II. Final report Sep 77-Oct 81

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, L.; Kennedy, D.; Reid, G.

1981-10-01

The objectives of this investigation were to (1) develop safe practice guidelines that will minimize the chance of fires in underground fueling areas and (2) to develop a low-cost, reliable, automatic fire control system (AFCS) for underground fueling areas. Volume I of the report covered the period from June 21, 1976, to September 30, 1977, and included (1) the preparation of safe practice guidelines for underground fueling areas; (2) preparation of recommended AFCS design concepts for underground fueling areas; and (3) the design, fabrication, and in-mine fire test of an AFCS at Pine Creek Mine, Bishop, Calif. Volume II ofmore » the report covers the period from September 30, 1977, to September 30, 1981, and includes (1) a long-term validation test of the AFCS in the Pine Creek Mine, (2) a study of the environmental effects of aqueous film-forming foam, (3) the design and installation of a system at AMAX Buick Mine, Boss, Mo., (4) the design of a system for enclosed fuel areas, and (5) the design of a system for semipermanent fueling areas.« less

Species divergence and phylogenetic variation of ecophysiological traits in lianas and trees.

PubMed

Rios, Rodrigo S; Salgado-Luarte, Cristian; Gianoli, Ernesto

2014-01-01

The climbing habit is an evolutionary key innovation in plants because it is associated with enhanced clade diversification. We tested whether patterns of species divergence and variation of three ecophysiological traits that are fundamental for plant adaptation to light environments (maximum photosynthetic rate [A(max)], dark respiration rate [R(d)], and specific leaf area [SLA]) are consistent with this key innovation. Using data reported from four tropical forests and three temperate forests, we compared phylogenetic distance among species as well as the evolutionary rate, phylogenetic distance and phylogenetic signal of those traits in lianas and trees. Estimates of evolutionary rates showed that R(d) evolved faster in lianas, while SLA evolved faster in trees. The mean phylogenetic distance was 1.2 times greater among liana species than among tree species. Likewise, estimates of phylogenetic distance indicated that lianas were less related than by chance alone (phylogenetic evenness across 63 species), and trees were more related than expected by chance (phylogenetic clustering across 71 species). Lianas showed evenness for R(d), while trees showed phylogenetic clustering for this trait. In contrast, for SLA, lianas exhibited phylogenetic clustering and trees showed phylogenetic evenness. Lianas and trees showed patterns of ecophysiological trait variation among species that were independent of phylogenetic relatedness. We found support for the expected pattern of greater species divergence in lianas, but did not find consistent patterns regarding ecophysiological trait evolution and divergence. R(d) followed the species-level pattern, i.e., greater divergence/evolution in lianas compared to trees, while the opposite occurred for SLA and no pattern was detected for A(max). R(d) may have driven lianas' divergence across forest environments, and might contribute to diversification in climber clades.

PA1 Protein, a New Competitive Decelerator Acting at More than One Step to Impede Glucocorticoid Receptor-mediated Transactivation*

PubMed Central

Zhang, Zhenhuan; Sun, Yunguang; Cho, Young-Wook; Chow, Carson C.; Simons, S. Stoney

2013-01-01

Numerous cofactors modulate the gene regulatory activity of glucocorticoid receptors (GRs) by affecting one or more of the following three major transcriptional properties: the maximal activity of agonists (Amax), the potency of agonists (EC50), and the partial agonist activity of antisteroids (PAA). Here, we report that the recently described nuclear protein, Pax2 transactivation domain interaction protein (PTIP)-associated protein 1 (PA1), is a new inhibitor of GR transactivation. PA1 suppresses Amax, increases the EC50, and reduces the PAA of an exogenous reporter gene in a manner that is independent of associated PTIP. PA1 is fully active with, and strongly binds to, the C-terminal half of GR. PA1 reverses the effects of the coactivator TIF2 on GR-mediated gene induction but is unable to augment the actions of the corepressor SMRT. Analysis of competition assays between PA1 and TIF2 with an exogenous reporter indicates that the kinetic definition of PA1 action is a competitive decelerator at two sites upstream from where TIF2 acts. With the endogenous genes IGFBP1 and IP6K3, PA1 also represses GR induction, increases the EC50, and decreases the PAA. ChIP and re-ChIP experiments indicate that PA1 accomplishes this inhibition of the two genes via different mechanisms as follows: PA1 appears to increase GR dissociation from and reduce GR transactivation at the IGFBP1 promoter regions but blocks GR binding to the IP6K3 promoter. We conclude that PA1 is a new competitive decelerator of GR transactivation and can act at more than one molecularly defined step in a manner that depends upon the specific gene. PMID:23161582

PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.

PubMed

Zhang, Zhenhuan; Sun, Yunguang; Cho, Young-Wook; Chow, Carson C; Simons, S Stoney

2013-01-04

Numerous cofactors modulate the gene regulatory activity of glucocorticoid receptors (GRs) by affecting one or more of the following three major transcriptional properties: the maximal activity of agonists (A(max)), the potency of agonists (EC(50)), and the partial agonist activity of antisteroids (PAA). Here, we report that the recently described nuclear protein, Pax2 transactivation domain interaction protein (PTIP)-associated protein 1 (PA1), is a new inhibitor of GR transactivation. PA1 suppresses A(max), increases the EC(50), and reduces the PAA of an exogenous reporter gene in a manner that is independent of associated PTIP. PA1 is fully active with, and strongly binds to, the C-terminal half of GR. PA1 reverses the effects of the coactivator TIF2 on GR-mediated gene induction but is unable to augment the actions of the corepressor SMRT. Analysis of competition assays between PA1 and TIF2 with an exogenous reporter indicates that the kinetic definition of PA1 action is a competitive decelerator at two sites upstream from where TIF2 acts. With the endogenous genes IGFBP1 and IP6K3, PA1 also represses GR induction, increases the EC(50), and decreases the PAA. ChIP and re-ChIP experiments indicate that PA1 accomplishes this inhibition of the two genes via different mechanisms as follows: PA1 appears to increase GR dissociation from and reduce GR transactivation at the IGFBP1 promoter regions but blocks GR binding to the IP6K3 promoter. We conclude that PA1 is a new competitive decelerator of GR transactivation and can act at more than one molecularly defined step in a manner that depends upon the specific gene.

Effects of elevated atmospheric CO2 concentration on leaf dark respiration of Xanthium strumarium in light and in darkness

PubMed Central

Wang, Xianzhong; Lewis, James D.; Tissue, David T.; Seemann, Jeffrey R.; Griffin, Kevin L.

2001-01-01

Leaf dark respiration (R) is an important component of plant carbon balance, but the effects of rising atmospheric CO2 on leaf R during illumination are largely unknown. We studied the effects of elevated CO2 on leaf R in light (RL) and in darkness (RD) in Xanthium strumarium at different developmental stages. Leaf RL was estimated by using the Kok method, whereas leaf RD was measured as the rate of CO2 efflux at zero light. Leaf RL and RD were significantly higher at elevated than at ambient CO2 throughout the growing period. Elevated CO2 increased the ratio of leaf RL to net photosynthesis at saturated light (Amax) when plants were young and also after flowering, but the ratio of leaf RD to Amax was unaffected by CO2 levels. Leaf RN was significantly higher at the beginning but significantly lower at the end of the growing period in elevated CO2-grown plants. The ratio of leaf RL to RD was used to estimate the effect of light on leaf R during the day. We found that light inhibited leaf R at both CO2 concentrations but to a lesser degree for elevated (17–24%) than for ambient (29–35%) CO2-grown plants, presumably because elevated CO2-grown plants had a higher demand for energy and carbon skeletons than ambient CO2-grown plants in light. Our results suggest that using the CO2 efflux rate, determined by shading leaves during the day, as a measure for leaf R is likely to underestimate carbon loss from elevated CO2-grown plants. PMID:11226264

Effects of elevated atmospheric CO2 concentration on leaf dark respiration of Xanthium strumarium in light and in darkness.

PubMed

Wang, X; Lewis, J D; Tissue, D T; Seemann, J R; Griffin, K L

2001-02-27

Leaf dark respiration (R) is an important component of plant carbon balance, but the effects of rising atmospheric CO(2) on leaf R during illumination are largely unknown. We studied the effects of elevated CO(2) on leaf R in light (R(L)) and in darkness (R(D)) in Xanthium strumarium at different developmental stages. Leaf R(L) was estimated by using the Kok method, whereas leaf R(D) was measured as the rate of CO(2) efflux at zero light. Leaf R(L) and R(D) were significantly higher at elevated than at ambient CO(2) throughout the growing period. Elevated CO(2) increased the ratio of leaf R(L) to net photosynthesis at saturated light (A(max)) when plants were young and also after flowering, but the ratio of leaf R(D) to A(max) was unaffected by CO(2) levels. Leaf R(N) was significantly higher at the beginning but significantly lower at the end of the growing period in elevated CO(2)-grown plants. The ratio of leaf R(L) to R(D) was used to estimate the effect of light on leaf R during the day. We found that light inhibited leaf R at both CO(2) concentrations but to a lesser degree for elevated (17-24%) than for ambient (29-35%) CO(2)-grown plants, presumably because elevated CO(2)-grown plants had a higher demand for energy and carbon skeletons than ambient CO(2)-grown plants in light. Our results suggest that using the CO(2) efflux rate, determined by shading leaves during the day, as a measure for leaf R is likely to underestimate carbon loss from elevated CO(2)-grown plants.

Sustained diurnal photosynthetic depression in uppermost-canopy leaves of four dipterocarp species in the rainy and dry seasons: does photorespiration play a role in photoprotection?

PubMed

Zhang, J-L; Meng, L-Z; Cao, K-F

2009-02-01

Diurnal and seasonal changes in gas exchange and chlorophyll fluorescence of the uppermost-canopy leaves of four evergreen dipterocarp species were measured on clear days. The trees, that were growing in a plantation stand in southern Yunnan, China, had canopy heights ranging from 17 to 22 m. In the rainy season, Dipterocarpus retusus Bl. had higher photosynthetic capacity (A(max)) than Hopea hainanensis Merr. et Chun, Parashorea chinensis Wang Hsie and Vatica xishuangbannaensis G.D. Tao et J.H. Zhang (17.7 versus 13.9, 11.8 and 7.7 micromol m(-2) s(-1), respectively). In the dry season, A(max) in all species decreased by 52-64%, apparent quantum yield and dark respiration rate decreased in three species, and light saturation point decreased in two species. During the diurnal courses, all species exhibited sustained photosynthetic depression from midmorning onward in both seasons. The trees were able to regulate light energy allocation dynamically between photochemistry and heat dissipation during the day, with reduced actual photochemistry and increased heat dissipation in the dry season. Photorespiration played an important role in photoprotection in all species in both seasons, as indicated by a continuous increase in photorespiration rate in the morning toward midday and a high proportion of electron flow (about 30-65% of total electron flow) allocated to oxygenation for most of the day. None of the species suffered irreversible photoinhibition, even in the dry season. The sustained photosynthetic depression in the uppermost-canopy leaves of these species could be a protective response to prevent excessive water loss and consequent catastrophic leaf hydraulic dysfunction.

In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows

PubMed Central

Pfeiffer, Julia B. R.; Mevissen, Meike; Steiner, Adrian; Portier, Christopher J.; Meylan, Mireille

2009-01-01

Objective To describe the in vitro effects of bethanechol on contractility of smooth muscle preparations from the small intestines of healthy cows and define the muscarinic receptor subtypes involved in mediating contraction. Sample Population Tissue samples from the duodenum and jejunum collected immediately after slaughter of 40 healthy cows. Procedures Cumulative concentration-response curves were determined for the muscarinic receptor agonist bethanechol with or without prior incubation with subtype-specific receptor antagonists in an organ bath. Effects of bethanechol and antagonists and the influence of intestinal location on basal tone, maximal amplitude (Amax), and area under the curve (AUC) were evaluated. Results Bethanechol induced a significant, concentration-dependent increase in all preparations and variables. The effect of bethanechol was more pronounced in jejunal than in duodenal samples and in circular than in longitudinal preparations. Significant inhibition of the effects of bethanechol was observed after prior incubation with muscarinic receptor subtype M3 antagonists (more commonly for basal tone than for Amax and AUC). The M2 receptor antagonists partly inhibited the response to bethanechol, especially for basal tone. The M3 receptor antagonists were generally more potent than the M2 receptor antagonists. In a protection experiment, an M3 receptor antagonist was less potent than when used in combination with an M2 receptor antagonist. Receptor antagonists for M1 and M4 did not affect contractility variables. Conclusions and Clinical Relevance Bethanechol acting on muscarinic receptor subtypes M2 and M3 may be of clinical use as a prokinetic drug for motility disorders of the duodenum and jejunum in dairy cows. PMID:17331022

Species Divergence and Phylogenetic Variation of Ecophysiological Traits in Lianas and Trees

PubMed Central

Rios, Rodrigo S.; Salgado-Luarte, Cristian; Gianoli, Ernesto

2014-01-01

The climbing habit is an evolutionary key innovation in plants because it is associated with enhanced clade diversification. We tested whether patterns of species divergence and variation of three ecophysiological traits that are fundamental for plant adaptation to light environments (maximum photosynthetic rate [Amax], dark respiration rate [Rd], and specific leaf area [SLA]) are consistent with this key innovation. Using data reported from four tropical forests and three temperate forests, we compared phylogenetic distance among species as well as the evolutionary rate, phylogenetic distance and phylogenetic signal of those traits in lianas and trees. Estimates of evolutionary rates showed that Rd evolved faster in lianas, while SLA evolved faster in trees. The mean phylogenetic distance was 1.2 times greater among liana species than among tree species. Likewise, estimates of phylogenetic distance indicated that lianas were less related than by chance alone (phylogenetic evenness across 63 species), and trees were more related than expected by chance (phylogenetic clustering across 71 species). Lianas showed evenness for Rd, while trees showed phylogenetic clustering for this trait. In contrast, for SLA, lianas exhibited phylogenetic clustering and trees showed phylogenetic evenness. Lianas and trees showed patterns of ecophysiological trait variation among species that were independent of phylogenetic relatedness. We found support for the expected pattern of greater species divergence in lianas, but did not find consistent patterns regarding ecophysiological trait evolution and divergence. Rd followed the species-level pattern, i.e., greater divergence/evolution in lianas compared to trees, while the opposite occurred for SLA and no pattern was detected for Amax. Rd may have driven lianas' divergence across forest environments, and might contribute to diversification in climber clades. PMID:24914958

A high proportion of blue light increases the photosynthesis capacity and leaf formation rate of Rosa × hybrida but does not affect time to flower opening.

PubMed

Terfa, Meseret Tesema; Solhaug, Knut Asbjørn; Gislerød, Hans Ragnar; Olsen, Jorunn Elisabeth; Torre, Sissel

2013-05-01

Alterations in light quality affect plant morphogenesis and photosynthetic responses but the effects vary significantly between species. Roses exhibit an irradiance-dependent flowering control but knowledge on light quality responses is scarce. In this study we analyzed, the responses in morphology, photosynthesis and flowering of Rosa × hybrida to different blue (B) light proportions provided by light-emitting diodes (LED, high B 20%) and high pressure sodium (HPS, low B 5%) lamps. There was a strong morphological and growth effect of the light sources but no significant difference in total dry matter production and flowering. HPS-grown plants had significantly higher leaf area and plant height, yet a higher dry weight proportion was allocated to leaves than stems under LED. LED plants showed 20% higher photosynthetic capacity (Amax ) and higher levels of soluble carbohydrates. The increase in Amax correlated with an increase in leaf mass per unit leaf area, higher stomata conductance and CO2 exchange, total chlorophyll (Chl) content per area and Chl a/b ratio. LED-grown leaves also displayed a more sun-type leaf anatomy with more and longer palisade cells and a higher stomata frequency. Although floral initiation occurred at a higher leaf number in LED, the time to open flowers was the same under both light conditions. Thereby the study shows that a higher portion of B light is efficient in increasing photosynthesis performance per unit leaf area, enhancing growth and morphological changes in roses but does not affect the total Dry Matter (DM) production or time to open flower. Copyright © Physiologia Plantarum 2012.

Are species photosynthetic characteristics good predictors of seedling post-hurricane demographic patterns and species spatiotemporal distribution in a hurricane impacted wet montane forest?

NASA Astrophysics Data System (ADS)

Luke, Denneko; McLaren, Kurt

2018-05-01

In situ measurements of leaf level photosynthetic response to light were collected from seedlings of ten tree species from a tropical montane wet forest, the John Crow Mountains, Jamaica. A model-based recursive partitioning ('mob') algorithm was then used to identify species associations based on their fitted photosynthetic response curves. Leaf area dark respiration (RD) and light saturated maximum photosynthetic (Amax) rates were also used as 'mob' partitioning variables, to identify species associations based on seedling demographic patterns (from June 2007 to May 2010) following a hurricane (Aug. 2007) and the spatiotemporal distribution patterns of stems in 2006 and 2012. RD and Amax rates ranged from 1.14 to 2.02 μmol (CO2) m-2s-1 and 2.97-5.87 μmol (CO2) m-2s-1, respectively, placing the ten species in the range of intermediate shade tolerance. Several parsimonious species 'mob' groups were formed based on 1) interspecific differences among species response curves, 2) variations in post-hurricane seedling demographic trends and 3) RD rates and species spatiotemporal distribution patterns at aspects that are more or less exposed to hurricanes. The composition of parsimonious groupings based on photosynthetic curves was not concordant with the groups based on demographic trends but was partially concordant with the RD - species spatiotemporal distribution groups. Our results indicated that the influence of photosynthetic characteristics on demographic traits and species distributions was not straightforward. Rather, there was a complex pattern of interaction between ecophysiological and demographic traits, which determined species successional status, post-hurricane response and ultimately, species distribution at our study site.

Species-specific and seasonal differences in chlorophyll fluorescence and photosynthetic light response among three evergreen species in a Madrean sky island mixed conifer forest

NASA Astrophysics Data System (ADS)

Potts, D. L.; Minor, R. L.; Braun, Z.; Barron-Gafford, G. A.

2012-12-01

Unlike the snowmelt-dominated hydroclimate of more northern mountainous regions, the hydroclimate of the Madrean sky islands is characterized by snowmelt and convective storms associated with the North American Monsoon. These mid-summer storms trigger biological activity and are important drivers of primary productivity. For example, at the highest elevations where mixed conifer forests occur, ecosystem carbon balance is influenced by monsoon rains. Whereas these storms' significance is increasingly recognized at the ecosystem scale, species-specific physiological responses to the monsoon are poorly known. Prior to and following monsoon onset, we measured pre-dawn and light-adapted chlorophyll fluorescence as well as photosynthetic light response in southwestern white pine (Pinus strobiformis), ponderosa pine (Pinus ponderosa), and Douglas fir (Pseudotsuga menziesii) in a Madrean sky island mixed conifer forest near Tucson, Arizona. Photochemical quenching (qp), an indicator of the proportion of open PSII reaction centers, was greatest in P. strobiformis and least in P. menziesii and increased in response to monsoon rains (repeated-measures ANOVA; species, F2,14 = 6.17, P = 0.012; time, F2,14= 8.17, P = 0.013). In contrast, non-photochemical quenching (qN), an indicator of heat dissipation ability, was greatest in P. ponderosa and least in P. menziesii, but was not influenced by monsoon onset (repeated-measures ANOVA; species, F2,12 = 4.18, P = 0.042). Estimated from leaf area-adjusted photosynthetic light response curves, maximum photosynthetic rate (Amax) was greatest in P. ponderosa and least in P. menziesii (repeated-measures ANOVA; species, F2,8= 40.8, P = 0.001). Surprisingly, while the monsoon positively influenced Amax among P. ponderosa and P. strobiformis, Amax of P. menziesii declined with monsoon onset (repeated-measures ANOVA; species x time, F2,8 = 13.8, P = 0.002). Calculated as the initial slope of the photosynthetic light response curve, light-use efficiency (AQE) was similar among P. strobiformis and P. ponderosa and least in P. menziesii (repeated-measures ANOVA; species, F2,8 = 13.83, P = 0.002). Across all three species, monsoon onset increased AQE (repeated-measures ANOVA; time, F1,8= 10.04, P = 0.01). Likewise, P. strobiformis and P. ponderosa shared a similar, greater light compensation point than P. menziesii (repeated-measures ANOVA; species, F2,8 = 5.89, P = 0.02). However, across species, monsoon onset did not influence light compensation points. These results support the hypothesis that the monsoon has species-specific effects on evergreen physiological performance and are broadly consistent with predictions of stress tolerance based on species' latitudinal and elevational range distributions. Moreover, with year-to-year rainfall variability predicted to increase under future climate scenarios, species-specific functional traits related to stress tolerance and photosynthesis may promote ecosystem functional resilience in Madrean sky island mixed conifer forests.

Observations relating extreme multi-basin river flows to very severe gales

NASA Astrophysics Data System (ADS)

Hillier, John; De Luca, Paolo; Wilby, Rob; Quinn, Nevil; Harrigan, Shaun

2017-04-01

Fluvial foods are typically investigated as 'events' at the single basin scale. However, applying a recently developed methodology to identify the largest multi-basin peak flow events allows a statistically significant relationship between them and episodes of very severe gales (VSG) to be identified; such a systematic link has previously only very tentatively been proposed for extra-tropical cyclone seasons, where damaging wind and rain are commonly non-synchronous. Annual maximum river peak flow (AMAX) data during 1975-2014 for 261 non-nested catchments (i.e. with no other sites upstream) in Great Britain are used, and a 13-day window is selected. A simple correlation between metrics that are proxies for damaging wind and flooding is statistically significant (r = 0.41, p = 0.0088). Also, taking the most severe 50% and 30% of years for wind and flow respectively, co-occurrence is expected 6.6 times in 40 years whilst 10 are observed (p = 0.021; simulation with n = 10,000), making co-occurrence of the extremes 52% more likely than expected by chance. This has implications for emergency response and financial planning (e.g. insurance).

Use of digital webcam images to track spring green-up in a deciduous broadleaf forest.

PubMed

Richardson, Andrew D; Jenkins, Julian P; Braswell, Bobby H; Hollinger, David Y; Ollinger, Scott V; Smith, Marie-Louise

2007-05-01

Understanding relationships between canopy structure and the seasonal dynamics of photosynthetic uptake of CO(2) by forest canopies requires improved knowledge of canopy phenology at eddy covariance flux tower sites. We investigated whether digital webcam images could be used to monitor the trajectory of spring green-up in a deciduous northern hardwood forest. A standard, commercially available webcam was mounted at the top of the eddy covariance tower at the Bartlett AmeriFlux site. Images were collected each day around midday. Red, green, and blue color channel brightness data for a 640 x 100-pixel region-of-interest were extracted from each image. We evaluated the green-up signal extracted from webcam images against changes in the fraction of incident photosynthetically active radiation that is absorbed by the canopy (f (APAR)), a broadband normalized difference vegetation index (NDVI), and the light-saturated rate of canopy photosynthesis (A(max)), inferred from eddy flux measurements. The relative brightness of the green channel (green %) was relatively stable through the winter months. A steady rising trend in green % began around day 120 and continued through day 160, at which point a stable plateau was reached. The relative brightness of the blue channel (blue %) also responded to spring green-up, although there was more day-to-day variation in the signal because blue % was more sensitive to changes in the quality (spectral distribution) of incident radiation. Seasonal changes in blue % were most similar to those in f (APAR) and broadband NDVI, whereas changes in green % proceeded more slowly, and were drawn out over a longer period of time. Changes in A(max) lagged green-up by at least a week. We conclude that webcams offer an inexpensive means by which phenological changes in the canopy state can be quantified. A network of cameras could offer a novel opportunity to implement a regional or national phenology monitoring program.

Ecophysiological responses of two herbaceous species to prescribed burning, alone or in combination with overstory thinning.

PubMed

Huang, Jianjun; Boerner, Ralph E J; Rebbeck, Joanne

2007-05-01

The oak-rich deciduous forests of the central Appalachian Mountains of eastern North America have changed significantly since the onset of effective fire suppression early in the 20th century. Those changes have resulted in progressively decreasing light and nutrient supplies to herbaceous perennial understory species. Application of ecological restoration treatments such as reintroduction of frequent dormant-season fire and overstory thinning to pre-suppression density often increase light, soil temperature and moisture, and short-term nutrient availability to pre-suppression levels. To persist in this environment, perennial understory herbs must be able to acclimate phenotypically to the very different resource supply combinations present with and without fire suppression. As part of a larger study of the response of the long-lived herbaceous perennials Desmodium nudiflorum and Panicum boscii to ecosystem restoration treatments in Ohio mixed-oak forests, this study examined the ecophysiological effects of prescribed burning (B) and the combination of burning and thinning (T + B) in mixed-oak forests in southern Ohio. Control (C) plants had significantly lower maximum photosynthetic rate (A(max)) than those in the treated plots. The enhancement of A(max) averaged 26.7% and 52.7% in the B and T + B treatments, respectively. Plants from the T + B plots had higher quantum yield, stomatal conductance, and photosynthetic nutrient use efficiency than B and C plants. B plants had greater intrinsic water use efficiency (WUE) than plants in the C or T + B treatments. Light saturation point (LSP), light compensation point (LCP), and "dark" respiration (DR) did not differ among treatments. Photosynthetic parameters did vary significantly between the species, but no significant treatment × species interactions were detected. Our results support the hypothesis that prescribed burning, especially when combined with overstory thinning, in these perennial herbs can result in phenotypic acclimation characterized by enhanced photosynthetic performance.

Influence of Material Selection on the Marginal Accuracy of CAD/CAM-Fabricated Metal- and All-Ceramic Single Crown Copings

PubMed Central

Schneider, Lea; Rinke, Sven

2018-01-01

This study evaluated the marginal accuracy of CAD/CAM-fabricated crown copings from four different materials within the same processing route. Twenty stone replicas of a metallic master die (prepared upper premolar) were scanned and divided into two groups. Group 1 (n = 10) was used for a pilot test to determine the design parameters for best marginal accuracy. Group 2 (n = 10) was used to fabricate 10 specimens from the following materials with one identical CAD/CAM system (GAMMA 202, Wissner GmbH, Goettingen, Germany): A = commercially pure (cp) titanium, B = cobalt-chromium alloy, C = yttria-stabilized zirconia (YSZ), and D = leucite-reinforced glass-ceramics. Copings from group 2 were evaluated for the mean marginal gap size (MeanMG) and average maximum marginal gap size (AMaxMG) with a light microscope in the “as-machined” state. The effect of the material on the marginal accuracy was analyzed by multiple pairwise comparisons (Mann–Whitney, U-test, α = 0.05, adjusted by Bonferroni-Holmes method). MeanMG values were as follows: A: 46.92 ± 23.12 μm, B: 48.37 ± 29.72 μm, C: 68.25 ± 28.54 μm, and D: 58.73 ± 21.15 μm. The differences in the MeanMG values proved to be significant for groups A/C (p = 0.0024), A/D (p = 0.008), and B/C (p = 0.0332). AMaxMG values (A: 91.54 ± 23.39 μm, B: 96.86 ± 24.19 μm, C: 120.66 ± 32.75 μm, and D: 100.22 ± 10.83 μm) revealed no significant differences. The material had a significant impact on the marginal accuracy of CAD/CAM-fabricated copings. PMID:29765979

Effects of water stress on irradiance acclimation of leaf traits in almond trees.

PubMed

Egea, Gregorio; González-Real, María M; Baille, Alain; Nortes, Pedro A; Conesa, María R; Ruiz-Salleres, Isabel

2012-04-01

Photosynthetic acclimation to highly variable local irradiance within the tree crown plays a primary role in determining tree carbon uptake. This study explores the plasticity of leaf structural and physiological traits in response to the interactive effects of ontogeny, water stress and irradiance in adult almond trees that have been subjected to three water regimes (full irrigation, deficit irrigation and rain-fed) for a 3-year period (2006-08) in a semiarid climate. Leaf structural (dry mass per unit area, N and chlorophyll content) and photosynthetic (maximum net CO(2) assimilation, A(max), maximum stomatal conductance, g(s,max), and mesophyll conductance, g(m)) traits and stem-to-leaf hydraulic conductance (K(s-l)) were determined throughout the 2008 growing season in leaves of outer south-facing (S-leaves) and inner northwest-facing (NW-leaves) shoots. Leaf plasticity was quantified by means of an exposure adjustment coefficient (ε=1-X(NW)/X(S)) for each trait (X) of S- and NW-leaves. Photosynthetic traits and K(s-l) exhibited higher irradiance-elicited plasticity (higher ε) than structural traits in all treatments, with the highest and lowest plasticity being observed in the fully irrigated and rain-fed trees, respectively. Our results suggest that water stress modulates the irradiance-elicited plasticity of almond leaves through changes in crown architecture. Such changes lead to a more even distribution of within-crown irradiance, and hence of the photosynthetic capacity, as water stress intensifies. Ontogeny drove seasonal changes only in the ε of area- and mass-based N content and mass-based chlorophyll content, while no leaf age-dependent effect was observed on ε as regards the physiological traits. Our results also indicate that the irradiance-elicited plasticity of A(max) is mainly driven by changes in leaf dry mass per unit area, in g(m) and, most likely, in the partitioning of the leaf N content.

The dust scattering halo of Cygnus X-3

NASA Astrophysics Data System (ADS)

Corrales, L. R.; Paerels, F.

2015-10-01

Dust grains scatter X-ray light through small angles, producing a diffuse halo image around bright X-ray point sources situated behind a large amount of interstellar material. We present analytic solutions to the integral for the dust scattering intensity, which allow for a Bayesian analysis of the scattering halo around Cygnus X-3. Fitting the optically thin 4-6 keV halo surface brightness profile yields the dust grain size and spatial distribution. We assume a power-law distribution of grain sizes (n ∝ a-p) and fit for p, the grain radius cut-off amax, and dust mass column. We find that a p ≈ 3.5 dust grain size distribution with amax ≈ 0.2 μm fits the halo profile relatively well, whether the dust is distributed uniformly along the line of sight or in clumps. We find that a model consisting of two dust screens, representative of foreground spiral arms, requires the foreground Perseus arm to contain 80 per cent of the total dust mass. The remaining 20 per cent of the dust, which may be associated with the outer spiral arm of the Milky Way, is located within 1 kpc of Cyg X-3. Regardless of which model was used, we found τ_sca ˜ 2 E_keV^{-2}. We examine the energy resolved haloes of Cyg X-3 from 1 to 6 keV and find that there is a sharp drop in scattering halo intensity when E < 2-3 keV, which cannot be explained with multiple scattering effects. We hypothesize that this may be caused by large dust grains or material with unique dielectric properties, causing the scattering cross-section to depart from the Rayleigh-Gans approximation that is used most often in X-ray scattering studies. The foreground Cyg OB2 association, which contains several evolved stars with large extinction values, is a likely culprit for grains of unique size or composition.

FOURFIT-A Computer Code for Determining Equivalent Nuclear Yield and Peak Overpressure by a Fourier Spectrum Fit Method

DTIC Science & Technology

1984-05-25

PLOT IS LINEAR-LINEAR ** C 50 LINET *0 *1’LINES *0 73 C CALL SCLI (XMN.XMX.XORG,XSTP.XEND) CALL SCL I( YMN. YMXYORG. YSTP.NEND) WRITE(6,2303... SCLI XMNXMX~ *.2(FS.4,2X)) SMIN =0.00006 S(1) z 0.00012 S(2) -0.00018 S13) =0.00024 S(4) =0.00030 .%4 S(5) =0. 00036 S(6) = 0.00060 S(7) =0.00120 C DIF...DSTP a SM!Pd/3.0 C 75 *.1z 99 £006 a DORG ASTP a DSTP * AMAX a DUSAX WRITE(6.2303) DORG.DSTP.DMAX 2303 FOOUAT(SX.s LEAVING SCLI *.3(F8.4.2x)) C

Reforestation as a post-mining land use in the Midwest

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parr, D.E.

1982-12-01

With the passage of the Surface Mining Control and Reclamation Act of 1977 (P.L. 95-87), some very stringent requirements for the successful establishment of trees and shrubs have come into effect. In response to these requirements, AMAX Coal Company is developing a reforestation program for seven surface mines in Indiana and Illinois using the best technology currently available. The program emphasizes obtaining good quality stock, the proper care and handling of stock, the proper planting of the stock, and an effective weed control program. The value of weed control for the establishment and growth of hardwoods has long been recognizedmore » in the forest industry, but has not been used extensively in the reforestation of surface mined lands. The improved survival of tree seedlings with the use of weed control justifies the additional cost. Weed control also enhances the growth of tree seedlings. However, the long term growth of seedlings is questionable due to the compaction resulting from the extensive grading required to achieve approximate original contour. To minimize compaction, a forest area in Illinois is being minimally graded only to the extent necessary for environmental stability. Minimal grading is designed to reduce compaction which in turn will promote the development of a more productive forest resource.« less

Observation of development of breast cancer cell lines in real time by fluorescence microscopy under simulated microgravity

NASA Astrophysics Data System (ADS)

Lavan, David; Valdivia-Silva, Julio E.; Sanabria, Gabriela; Orihuela, Diego; Suarez, Juan; Quispe, Marco; Chuchon, Mariano; Martin, David; Maroto, Marcos; Egea, Javier

2016-07-01

This project consist in the implementation of a fluorescence microscope for the in real time monitoring of biological labeled samples by several fluorophores in microgravity conditions keeping the temperature, humidity, and (CO)2 controlled by an electronic platform. The system (fluorescence microscope and incubator) is integrated to a microgravity simulator machine which was presented on the "30th Annual American Society for Gravitation and Space Research Meeting" October 2014 in Pasadena, CA, USA. Currently, we have the microgravity machine biologically validated by genetic expression studies in pupal stage of Drosophila melanogaster. The fluorescence microscope has a platform designed to hold a culture flask, and a fluorescence camera (Leica DFC3000 G) connected to an optical system (Fluorescence Light source Leica EL6000, optic fiber, fiber adapter, and fluorescence filter) in order to take images in real time. The mechanical system of the fluorescence microsc ope is designed to allow the displacement of the fluorescence camera through a parallel plane to the culture flask's plane and also the movement of the platform through a perpendicular axis to the culture flask in order to focus the samples to the optical system. The mechanical system is propelled by four DC moto-reductors with encoder (A-max 26 Maxon motor, GP 32S screw and MR encoder) that generate displacements in the order of micrometers. The angular position control of the DC motoreductor's shaft of all the DC moto-reductors is done by PWM signals based on the interpretation of the signals provided by the encoders during the movement. The system is remotely operated by a graphic interface installed on a personal computer or any mobile device (smartphone, laptop or tablet) by using the internet. Acknowledgments: Grant of INNOVATE PERU (Formerly FINCYT)

Computer finds ore

NASA Astrophysics Data System (ADS)

Bell, Peter M.

Artificial intelligence techniques are being used for the first time to evaluate geophysical, geochemical, and geologic data and theory in order to locate ore deposits. After several years of development, an intelligent computer code has been formulated and applied to the Mount Tolman area in Washington state. In a project funded by the United States Geological Survey and the National Science Foundation a set of computer programs, under the general title Prospector, was used successfully to locate a previously unknown ore-grade porphyry molybdenum deposit in the vicinity of Mount Tolman (Science, Sept. 3, 1982).The general area of the deposit had been known to contain exposures of porphyry mineralization. Between 1964 and 1978, exploration surveys had been run by the Bear Creek Mining Company, and later exploration was done in the area by the Amax Corporation. Some of the geophysical data and geochemical and other prospecting surveys were incorporated into the programs, and mine exploration specialists contributed to a set of rules for Prospector. The rules were encoded as ‘inference networks’ to form the ‘expert system’ on which the artificial intelligence codes were based. The molybdenum ore deposit discovered by the test is large, located subsurface, and has an areal extent of more than 18 km2.

Seasonal variability in foliar characteristics and physiology for boreal forest species at the five Saskatchewan tower sites during the 1994 Boreal Ecosystem-Atmosphere Study

NASA Astrophysics Data System (ADS)

Middleton, E. M.; Sullivan, J. H.; Bovard, B. D.; Deluca, A. J.; Chan, S. S.; Cannon, T. A.

1997-12-01

Leaf-level measurements of gas exchange, chemistry, morphology, and spectral optical properties were acquired at the five instrumented tower sites during the three 1994 growing season intensive field campaigns (IFCs) conducted near Prince Albert, Saskatchewan, as part of the Boreal Ecosystem-Atmosphere Study (BOREAS). Stands included old and young aspen (OA, YA) associated with the hazelnut shrub, old and young jack pine (OJP, YJP) stands, and an old black spruce (OBS) stand; white spruce (at YA) and an understory herb (dogbane, at OJP) were also examined. Midsummer peak photosynthesis for aspen leaves in the field (A, light saturated) and laboratory (Amax light and CO2 saturated) was ˜12.6 and 33-41 μmol CO2 m-2 s-1. Black spruce exhibited the lowest A, 3 μmol CO2 m-2 s-1. Jack pine and black spruce attained their highest Amax (17-20 μmol CO2 m-2 s-1) in late summer/early fall. Gas exchange by white spruce was significantly higher and stomatal limitation lower than for other conifers, at levels comparable to broadleaf responses. White spruce foliage had the highest chlorophyll content in fall (˜41 μg cm-2), followed by aspen (OA) and hazelnut (YA) in midsummer (˜31 μg cm-2). Specific leaf mass of aspen, hazelnut, and conifer foliage was 86, ˜47, and ˜174 g m-2, respectively. Leaf nitrogen content of broadleaves (18-40 g N g-1 dry wt) was 2-3 times greater than conifer needles (8-12 g N g-1). Significantly larger needles were produced at OJP versus YJP, but needle number per age class was greater at YJP. The absorbed photosynthetically active radiation fraction (fAPAR) in June/July averaged ˜80% for broadleaves and ˜83% in conifer needles. The simple ratio (SR, near-infrared/red ratio) calculated from foliar transmittances was more strongly related to fAPAR than SR calculated from reflectances, with stronger correlation for broadleaves (r=0.92) than for conifers (r=0.78).

Productivity and CO2 exchange of Great Plains ecoregions. I. Shortgrass steppe: Flux tower estimates

USGS Publications Warehouse

Gilmanov, Tagir G.; Morgan, Jack A.; Hanan, Niall P.; Wylie, Bruce K.; Rajan, Nithya; Smith, David P.; Howard, Daniel M.

2017-01-01

The shortgrass steppe (SGS) occupies the southwestern part of the Great Plains. Half of the land is cultivated, but significant areas remain under natural vegetation. Despite previous studies of the SGS carbon cycle, not all aspects have been completely addressed, including gross productivity, ecosystem respiration, and ecophysiological parameters. Our analysis of 1998 − 2007 flux tower measurements at five Bowen ratio–energy balance (BREB) and three eddy covariance (EC) sites characterized seasonal and interannual variability of gross photosynthesis and ecosystem respiration. Identification of the nonrectangular hyperbolic equation for the diurnal CO2 exchange, with vapor pressure deficit (VPD) limitation and exponential temperature response, quantified quantum yield α, photosynthetic capacity Amax, and respiration rate rd with variation ranges (19 \\< α \\< 51 mmol mol− 1, 0.48 \\< Amax \\< 2.1 mg CO2 m− 2 s− 1, 0.15 \\< rd \\< 0.49 mg CO2 m− 2 s− 1). Gross photosynthesis varied from 1 100 to 2 700 g CO2 m− 2 yr− 1, respiration from 900 to 3,000 g CO2 m− 2 yr− 1, and net ecosystem production from − 900 to + 700 g CO2 m− 2 yr− 1, indicating that SGS may switch from a sink to a source depending on weather. Comparison of the 2004 − 2006 measurements at two BREB and two parallel EC flux towers located at comparable SGS sites showed moderately higher photosynthesis, lower respiration, and higher net production at the BREB than EC sites. However, the difference was not related only to methodologies, as the normalized difference vegetation index at the BREB sites was higher than at the EC sites. Overall magnitudes and seasonal patterns at the BREB and the EC sites during the 3-yr period were similar, with trajectories within the ± 1.5 standard deviation around the mean of the four sites and mostly reflecting the effects of meteorology.

High-resolution near-infrared speckle interferometry and radiative transfer modeling of the OH/IR star OH 104.9+2.4

NASA Astrophysics Data System (ADS)

Riechers, D.; Balega, Y.; Driebe, T.; Hofmann, K.-H.; Men'shchikov, A. B.; Weigelt, G.

2004-09-01

We present near-infrared speckle interferometry of the OH/IR star OH 104.9+2.4 in the K' band obtained with the 6 m telescope of the Special Astrophysical Observatory (SAO). At a wavelength of λ = 2.12 μm the diffraction-limited resolution of 74 mas was attained. The reconstructed visibility reveals a spherically symmetric, circumstellar dust shell (CDS) surrounding the central star. The visibility function shows that the stellar contribution to the total flux at λ = 2.12 μm is less than ˜50%, indicating a rather large optical depth of the CDS. The azimuthally averaged 1-dimensional Gaussian visibility fit yields a diameter of 47 ± 3 mas (FHWM), which corresponds to 112 ± 13 AU for an adopted distance of D = 2.38 ± 0.24 kpc. To determine the structure and the properties of the CDS of OH 104.9+2.4, radiative transfer calculations using the code DUSTY were performed to simultaneously model its visibility and the spectral energy distribution (SED). We found that both the ISO spectrum and the visibility of OH 104.9+2.4 can be well reproduced by a radiative transfer model with an effective temperature Teff = 2500 ± 500 K of the central source, a dust temperature Tin = 1000 ± 200 K at the inner shell boundary Rin ≃ 9.1 R* = 25.4 AU, an optical depth τ2.2 μm = 6.5 ± 0.3, and dust g rain radii ranging from amin = 0.005 ± 0.003 μm to amax = 0.2 ± 0.02 μm with a power law n(a) ∝ a-3.5. It was found that even minor changes in amax have a major impact on both the slope and the curvature of the visibility function, while the SED shows only minor changes. Our detailed analysis demonstrates the potential of dust shell modeling constrained by both the SED and visibilities. Based on data collected at the 6 m BTA telescope of the Special Astrophysical Observatory in Russia.

Effects of three phosphate industrial sites on ground-water quality in central Florida, 1979 to 1980

USGS Publications Warehouse

Miller, R.L.; Sutcliffe, Horace

1984-01-01

Geologic, hydrologic, and water quality data and information on test holes collected in the vicinity of gypsum stack complexes at two phosphate chemical plants and one phosphatic clayey waste disposal pond at a phosphate mine and beneficiation plant in central Florida are presented. The data were collected from September 1979 to October 1980 at the AMAX Phosphate, Inc. chemical plant, Piney Point; the USS Agri-Chemicals chemical plant, Bartow; and the International Minerals and Chemical Corporation Clear Springs mine, Bartow. Approximately 5,400 field and laboratory water quality determinations on water samples collected from about 100 test holes and 28 surface-water , 5 rainfall, and other sampling sites at phosphate industry beneficiation and chemical plant waste disposal operations are tabulated. Maps are included to show sampling sites. (USGS)

Water-quality and hydrogeologic data for three phosphate industry waste-disposal sites in central Florida, 1979-80

USGS Publications Warehouse

Miller, Ronald L.; Sutcliffe, Horace

1982-01-01

This report is a complilation of geologic, hydrologic, and water-quality data and information on test holes collected in the vicinity of gypsum stack complexes at two phosphate chemical plants and one phosphatic clayey waste disposal pond at a phosphate mine and beneficiation plant in central Florida. The data were collected from September 1979 to October 1980 at thee AMAX Phosphate, Inc., chemical plant, Piney Point; the USS AgriChemicals chemical plant, Bartow; and the International Minerals and Chemical Corporation Clear Springs mine, Bartow. Approximmmtely 5,400 field and laboratory water-quality determinations on water samples were collected from about 78 test holes and 31 surface-water, rainfall, and other sampling sites at phosphate industry beneficiation and chemical plant waste-disposal operations. Maps show locations of sampling sites. (USGS)

The Particle Size Distribution in Saturn’s C Ring from UVIS and VIMS Stellar Occultations and RSS Radio Occultations

NASA Astrophysics Data System (ADS)

Jerousek, Richard Gregory; Colwell, Josh; Hedman, Matthew M.; French, Richard G.; Marouf, Essam A.; Esposito, Larry; Nicholson, Philip D.

2017-10-01

The Cassini Ultraviolet Imaging Spectrograph (UVIS) and Visual and Infrared Mapping Spectrometer (VIMS) have measured ring optical depths over a wide range of viewing geometries at effective wavelengths of 0.15 μm and 2.9 μm respectively. Using Voyager S and X band radio occultations and the direct inversion of the forward scattered S band signal, Marouf et al. (1982), (1983), and Zebker et al. (1985) determined the power-law size distribution parameters assuming a minimum particle radius of 1 mm. Many further studies have also constrained aspects of the particle size distribution throughout the main rings. Marouf et al. (2008a) determined the smallest ring particles to have radii of 4-5 mm using Cassini RSS data. Harbison et al. (2013) used VIMS solar occultations and also found minimum particle sizes of 4-5 mm in the C ring with q ~ 3.1, where n(a)da=Ca^(-q)da is the assumed differential power-law size distribution for particles of radius a. Recent studies of excess variance in stellar signal by Colwell et al. (2017, submitted) constrain the cross-section-weighted effective particle radius to 1 m to several meters. Using the wide range of viewing geometries available to VIMS and UVIS stellar occultations we find that normal optical depth does not strongly depend on viewing geometry at 10km resolution (which would be the case if self-gravity wakes were present). Throughout the C ring, we fit power-law derived optical depths to those measured by UVIS, VIMS, and by the Cassini Radio Science Subsystem (RSS) at 0.94 and 3.6 cm wavelengths to constrain the four parameters of the size distribution at 10km radial resolution. We find significant amounts of particle size sorting throughout the region with a positive correlation between maximum particles size (amax) and normal optical depth with a mean value of amax ~ 3 m in the background C ring. This correlation is negative in the C ring plateaus. We find an inverse correlation in minimum particle radius with normal optical depth and a mean value of amin ~ 4 mm in the background C ring with slightly larger smallest particles in the C ring plateaus.

Phenology, growth and physiological adjustments of oil palm (Elaeis guineensis) to sink limitation induced by fruit pruning

PubMed Central

Legros, S.; Mialet-Serra, I.; Caliman, J.-P.; Siregar, F. A.; Clement-Vidal, A.; Fabre, D.; Dingkuhn, M.

2009-01-01

Background and Aims Despite its simple architecture and small phenotypic plasticity, oil palm has complex phenology and source–sink interactions. Phytomers appear in regular succession but their development takes years, involving long lag periods between environmental influences and their effects on sinks. Plant adjustments to resulting source–sink imbalances are poorly understood. This study investigated oil palm adjustments to imbalances caused by severe fruit pruning. Methods An experiment with two treatments (control and complete fruit pruning) during 22 months in 2006–2008) and six replications per treatment was conducted in Indonesia. Phenology, growth of above-ground vegetative and reproductive organs, leaf morphology, inflorescence sex differentiation, dynamics of non-structural carbohydrate reserves and light-saturated net photosynthesis (Amax) were monitored. Key Results Artificial sink limitation by complete fruit pruning accelerated development rate, resulting in higher phytomer, leaf and inflorescence numbers. Leaf size and morphology remained unchanged. Complete fruit pruning also suppressed the abortion of male inflorescences, estimated to be triggered at about 16 months before bunch maturity. The number of female inflorescences increased after an estimated lag of 24–26 months, corresponding to time from sex differentiation to bunch maturity. The most important adjustment process was increased assimilate storage in the stem, attaining nearly 50 % of dry weight in the stem top, mainly as starch, whereas glucose, which in controls was the most abundant non-structural carbohydrate stored in oil palm, decreased. Conclusions The development rate of oil palm is in part controlled by source–sink relationships. Although increased rate of development and proportion of female inflorescences constituted observed adjustments to sink limitation, the low plasticity of plant architecture (constant leaf size, absence of branching) limited compensatory growth. Non-structural carbohydrate storage was thus the main adjustment process. PMID:19748908

Extreme multi-basin flooding linked with extra-tropical cyclones

NASA Astrophysics Data System (ADS)

De Luca, Paolo; Hillier, John K.; Wilby, Robert L.; Quinn, Nevil W.; Harrigan, Shaun

2017-11-01

Fluvial floods are typically investigated as ‘events’ at the single basin-scale, hence flood management authorities may underestimate the threat of flooding across multiple basins driven by large-scale and nearly concurrent atmospheric event(s). We pilot a national-scale statistical analysis of the spatio-temporal characteristics of extreme multi-basin flooding (MBF) episodes, using peak river flow data for 260 basins in Great Britain (1975-2014), a sentinel region for storms impacting northwest and central Europe. During the most widespread MBF episode, 108 basins (~46% of the study area) recorded annual maximum (AMAX) discharge within a 16 day window. Such episodes are associated with persistent cyclonic and westerly atmospheric circulations, atmospheric rivers, and precipitation falling onto previously saturated ground, leading to hydrological response times <40 h and documented flood impacts. Furthermore, peak flows tend to occur after 0-13 days of very severe gales causing combined and spatially-distributed, yet differentially time-lagged, wind and flood damages. These findings have implications for emergency responders, insurers and contingency planners worldwide.

O3 flux-related responsiveness of photosynthesis, respiration, and stomatal conductance of adult Fagus sylvatica to experimentally enhanced free-air O3 exposure.

PubMed

Löw, M; Häberle, K-H; Warren, C R; Matyssek, R

2007-03-01

Knowledge of responses of photosynthesis, respiration, and stomatal conductance to cumulative ozone uptake (COU) is still scarce, and this is particularly the case for adult trees. The effect of ozone (O(3)) exposure on trees was examined with 60-year-old beech trees (FAGUS SYLVATICA) at a forest site of southern Germany. Trees were exposed to the ambient O(3) regime (1 x O(3)) or an experimentally elevated twice-ambient O(3) regime (2 x O(3)). The elevated 2 x O (3) regime was provided by means of a free-air O(3) canopy exposure system. The hypotheses were tested that (1) gas exchange is negatively affected by O(3) and (2) the effects of O(3) are dose-dependent and thus the sizes of differences between treatments are positively related to COU. Gas exchange (light-saturated CO(2) uptake rate A(max), stomatal conductance g (s), maximum rate of carboxylation Vc (max), ribulose-1,5-bisphosphate turnover limited rate of photosynthesis J (max), CO(2) compensation point CP, apparent quantum yield of net CO(2) uptake AQ, carboxylation efficiency CE, day- and nighttime respiration) and chlorophyll fluorescence (electron transfer rate, ETR) were measured IN SITU on attached sun and shade leaves. Measurements were made periodically throughout the growing seasons of 2003 (an exceptionally dry year) and 2004 (a year with average rainfall). In 2004 Vc(max), J(max), and CE were lower in trees receiving 2 x O(3) compared with the ambient O(3) regime (1 x O(3)). Treatment differences in Vc (max), J (max), CE were rather small in 2004 (i.e., parameter levels were lower by 10 - 30 % in 2 x O(3) than 1 x O(3)) and not significant in 2003. In 2004 COU was positively correlated with the difference between treatments in A (max), g (s), and ETR (i.e., consistent with the dose-dependence of O(3)'s deleterious effects). However, in 2003, differences in A(max), g (s), and ETR between the two O(3) regimes were smaller at the end of the dry summer 2003 (i.e., when COU was greatest). The relationship of COU with effects on gas exchange can apparently be complex and, in fact, varied between years and within the growing season. In addition, high doses of O(3) did not always have significant effects on leaf gas exchange. In view of the key findings, both hypotheses were to be rejected.

Soil warming effect on net ecosystem exchange of carbon dioxide during the transition from winter carbon source to spring carbon sink in a temperate urban lawn.

PubMed

Zhou, Xiaoping; Wang, Xiaoke; Tong, Lei; Zhang, Hongxing; Lu, Fei; Zheng, Feixiang; Hou, Peiqiang; Song, Wenzhi; Ouyang, Zhiyun

2012-01-01

The significant warming in urban environment caused by the combined effects of global warming and heat island has stimulated widely development of urban vegetations. However, it is less known of the climate feedback of urban lawn in warmed environment. Soil warming effect on net ecosystem exchange (NEE) of carbon dioxide during the transition period from winter to spring was investigated in a temperate urban lawn in Beijing, China. The NEE (negative for uptake) under soil warming treatment (temperature was about 5 degrees C higher than the ambient treatment as a control) was -0.71 micromol/(m2 x sec), the ecosytem was a CO2 sink under soil warming treatment, the lawn ecosystem under the control was a CO2 source (0.13 micromol/(m2 x sec)), indicating that the lawn ecosystem would provide a negative feedback to global warming. There was no significant effect of soil warming on nocturnal NEE (i.e., ecosystem respiration), although the soil temperature sensitivity (Q10) of ecosystem respiration under soil warming treatment was 3.86, much lower than that in the control (7.03). The CO2 uptake was significantly increased by soil warming treatment that was attributed to about 100% increase of alpha (apparent quantum yield) and Amax (maximum rate of photosynthesis). Our results indicated that the response of photosynthesis in urban lawn is much more sensitive to global warming than respiration in the transition period.

Mediational influence of spent mushroom compost on phytoremediation of black-oil hydrocarbon polluted soil and response of Megathyrsus maximus Jacq.

PubMed

Asemoloye, Michael Dare; Jonathan, Segun Gbolagade; Jayeola, Adeniyi A; Ahmad, Rafiq

2017-09-15

Ability of a plant to develop different adaptive strategies can also determine its capability for effective soil remediation. In this study, influence of spent mushroom compost (SMC) was tested on the phytoremediation of black oil hydrocarbon polluted soil and the response of Megathyrsus maximus (guinea grass). Studies were carried out in microcosm conditions by mixing different concentration of SMC viz., 10, 20, 30 and 40% in a 5 kg of contaminated soil along with control. Seeds of M. maximus was sown in tray for two weeks and allowed to grow for height of 10 cm and transplanted in to the different experimental pots. Soil nutrient, heavy metal and PAH contents were analyzed before and after the experiment. Ecophysiological and anatomical responses due to the contaminants in the soil by M. Maximus were analyzed after 120 days. Phytomass efficiency, potential photosynthesis (Amax) and contents of chlorophylls (a and b) as well as the total chlorophyll along with anatomical evaluations were recorded. Plant alone (control) reduced the soil heavy metal and PAH contents but further improvements were observed in SMC treatments, similar results were also observed as regards to the plant's phytoremediation efficiency (PE), phytomass and potential photosynthetic rates (m mol O 2  M -2 S -1 ). The plant's root and shoot anatomical responses were enhanced in treatments compared to control, study infers that the treatment enhances the biostimulation and development of adaptive characteristics for M. maximus survival in contaminated soils and promotes its co-degradation of hydrocarbon. SMC supports remediation and as well enhances the anatomical evaluations, we therefore recommend the use of SMC on response of Megathyrsus maximus Jacq for remediation of petrochemical based phytoremediation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Predictors of acute esophagitis in lung cancer patients treated with concurrent three-dimensional conformal radiotherapy and chemotherapy.

PubMed

Rodríguez, Núria; Algara, Manuel; Foro, Palmira; Lacruz, Marti; Reig, Anna; Membrive, Ismael; Lozano, Joan; López, José Luis; Quera, Jaime; Fernández-Velilla, Enric; Sanz, Xavier

2009-03-01

To evaluate the risk factors for acute esophagitis (AET) in lung cancer patients treated with concurrent 3D-CRT and chemotherapy. Data from 100 patients treated with concurrent chemoradiotherapy with a mean dose of 62.05 +/- 4.64 Gy were prospectively evaluated. Esophageal toxicity was graded according to criteria of the Radiation Therapy Oncology Group. The following dosimetric parameters were analyzed: length and volume of esophagus in treatment field, percentage of esophagus volume treated to >or=10, >or=20, >or=30, >or=35, >or=40, >or=45, >or=50, >or=55, and >or=60 Gy, and the maximum (D(max)) and mean doses (D(mean)) delivered to the esophagus. Also, we developed an esophagitis index (EI) to account the esophagitis grades over treatment time. A total of 59 patients developed AET (Grade 1, 26 patients; Grade 2, 29 patients; and Grade 3, 4 patients). V50 was associated with AET duration (p = 0.017), AET Grade 1 duration (p = 0.016), maximum analgesia (p = 0.019), esophagitis index score (p = 0.024), and AET Grade >or=1 (p = 0.058). If V50 is <30% there is a 47.3% risk of AET Grade >or=1, which increases to 73.3% if V50 is >or=30% (p = 0.008). The predictive abilities of models (sensitivity and specificity) were calculated by receiver operating characeristic curves. According to the receiver operating characeristic curve analysis, the 30% of esophageal volume receiving >or=50 Gy was the most statistically significant factor associated with AET Grade >or=1 and maximum analgesia (A(max)). There was an association with AET Grade >or=2 but it did not achieve statistical significance (p = 0.076).

Strategy of nitrogen acquisition and utilization by carnivorous Dionaea muscipula.

PubMed

Kruse, Jörg; Gao, Peng; Honsel, Anne; Kreuzwieser, Jürgen; Burzlaff, Tim; Alfarraj, Saleh; Hedrich, Rainer; Rennenberg, Heinz

2014-03-01

Plant carnivory represents an exceptional means to acquire N. Snap traps of Dionaea muscipula serve two functions, and provide both N and photosynthate. Using (13)C/(15)N-labelled insect powder, we performed feeding experiments with Dionaea plants that differed in physiological state and N status (spring vs. autumn plants). We measured the effects of (15)N uptake on light-saturated photosynthesis (A(max)), dark respiration (R(D)) and growth. Depending on N status, insect capture briefly altered the dynamics of R(D)/A(max), reflecting high energy demand during insect digestion and nutrient uptake, followed by enhanced photosynthesis and growth. Organic N acquired from insect prey was immediately redistributed, in order to support swift renewal of traps and thereby enhance probability of prey capture. Respiratory costs associated with permanent maintenance of the photosynthetic machinery were thereby minimized. Dionaea's strategy of N utilization is commensurate with the random capture of large prey, occasionally transferring a high load of organic nutrients to the plant. Our results suggest that physiological adaptations to unpredictable resource availability are essential for Dionaea's success with regards to a carnivorous life style.

Pervasive effects of a dominant foliar endophytic fungus on host genetic and phenotypic expression in a tropical tree

PubMed Central

Mejía, Luis C.; Herre, Edward A.; Sparks, Jed P.; Winter, Klaus; García, Milton N.; Van Bael, Sunshine A.; Stitt, Joseph; Shi, Zi; Zhang, Yufan; Guiltinan, Mark J.; Maximova, Siela N.

2014-01-01

It is increasingly recognized that macro-organisms (corals, insects, plants, vertebrates) consist of both host tissues and multiple microbial symbionts that play essential roles in their host's ecological and evolutionary success. Consequently, identifying benefits and costs of symbioses, as well as mechanisms underlying them are research priorities. All plants surveyed under natural conditions harbor foliar endophytic fungi (FEF) in their leaf tissues, often at high densities. Despite producing no visible effects on their hosts, experiments have nonetheless shown that FEF reduce pathogen and herbivore damage. Here, combining results from three genomic, and two physiological experiments, we demonstrate pervasive genetic and phenotypic effects of the apparently asymptomatic endophytes on their hosts. Specifically, inoculation of endophyte-free (E−) Theobroma cacao leaves with Colletotrichum tropicale (E+), the dominant FEF species in healthy T. cacao, induces consistent changes in the expression of hundreds of host genes, including many with known defensive functions. Further, E+ plants exhibited increased lignin and cellulose content, reduced maximum rates of photosynthesis (Amax), and enrichment of nitrogen-15 and carbon-13 isotopes. These phenotypic changes observed in E+ plants correspond to changes in expression of specific functional genes in related pathways. Moreover, a cacao gene (Tc00g04254) highly up-regulated by C. tropicale also confers resistance to pathogen damage in the absence of endophytes or their products in host tissues. Thus, the benefits of increased pathogen resistance in E+ plants are derived in part from up-regulation of intrinsic host defense responses, and appear to be offset by potential costs including reduced photosynthesis, altered host nitrogen metabolism, and endophyte heterotrophy of host tissues. Similar effects are likely in most plant-endophyte interactions, and should be recognized in the design and interpretation of genetic and phenotypic studies of plants. PMID:25309519

Simultaneous ozone fumigation and fluoranthene sprayed as mists negatively affected cherry tomato (Lycopersicon esculentum Mill).

PubMed

Oguntimehin, Ilemobayo; Eissa, Fawzy; Sakugawa, Hiroshi

2010-07-01

Ozone (O(3)) fumigated at 120 microg L(-1) for 12 hd(-1) was combined with 10 microM fluoranthene, and other treatments, including Mannitol solution to investigate the interaction of the two pollutants on tomato plant (Lycopersicon esculentum Mill). Using ten treatments including Mannitol solution and a control, exposure experiment was conducted for 34 d inside six growth chambers used for monitoring the resulted ecophysiological changes. Visible foliar injury, chlorophyll a fluorescence, leaf pigment contents, CO(2) uptake and water vapor exchange were monitored in tomato. Ozone or fluoranthene independently affected some ecophysiological traits of the tomato. In addition, simultaneous treatments with the duo had increased (additive) negative effects on the photosynthesis rate (A(max)), stomatal conductance (g(s)), chlorophyll pigment contents (Chl a, Chl b and Chl((a+b))) and visible foliar symptoms. Contrarily, alleviation of the negative effects of O(3) on the leaf chlorophyll a fluorescence variables by fluoranthene occurred. Mannitol solution, which functioned as a reactive oxygen species scavenger was able to mitigate some negative effects of the two pollutants on the tomato plants. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Light-induced vegetative anthocyanin pigmentation in Petunia

PubMed Central

Albert, Nick W.; Lewis, David H.; Zhang, Huaibi; Irving, Louis J.; Jameson, Paula E.; Davies, Kevin M.

2009-01-01

The Lc petunia system, which displays enhanced, light-induced vegetative pigmentation, was used to investigate how high light affects anthocyanin biosynthesis, and to assess the effects of anthocyanin pigmentation upon photosynthesis. Lc petunia plants displayed intense purple anthocyanin pigmentation throughout the leaves and stems when grown under high-light conditions, yet remain acyanic when grown under shade conditions. The coloured phenotypes matched with an accumulation of anthocyanins and flavonols, as well as the activation of the early and late flavonoid biosynthetic genes required for flavonol and anthocyanin production. Pigmentation in Lc petunia only occurred under conditions which normally induce a modest amount of anthocyanin to accumulate in wild-type Mitchell petunia [Petunia axillaris×(Petunia axillaris×Petunia hybrida cv. ‘Rose of Heaven’)]. Anthocyanin pigmentation in Lc petunia leaves appears to screen underlying photosynthetic tissues, increasing light saturation and light compensation points, without reducing the maximal photosynthetic assimilation rate (Amax). In the Lc petunia system, where the bHLH factor Leaf colour is constitutively expressed, expression of the bHLH (Lc) and WD40 (An11) components of the anthocyanin regulatory system were not limited, suggesting that the high-light-induced anthocyanin pigmentation is regulated by endogenous MYB transcription factors. PMID:19380423

Does canopy mean N concentration explain differences in light use efficiency in 14 eddy-covariance sites?

NASA Astrophysics Data System (ADS)

Peltoniemi, Mikko; Pulkkinen, Minna; Kolari, Pasi; Mäkelä, Annikki

2010-05-01

Production efficiency models aim at explaining variation of vegetation productivity with climatic input and information on vegetation cover often obtained from satellite observations. It has been acknowledged that different plant species differ in their potential to assimilate carbon dioxide per unit of PAR (i.e light use efficiency, LUE). Subsequently, some LUE-based models apply different LUE-coefficients for different plant functional types. Leaf N concentrations differ between plant species, and related differences in light saturated photosynthesis rate (A_max) have been detected. How much these differences affect the ecosystem production or LUE is more obscure. Canopies acclimate to prevailing environmental conditions, which causes variation e.g. in the proportion of leaves exposed to direct sunlight, leaf morphology, structure,orientation, and vertical N distibution. Furthermore, a fair proportion of photosynthesis occurs during cloudy days, in which case high A_max is unessential, and number of these days differs by location. We studied if canopy mean N concentration could explain differences in LUE derived for 14 forest sites using eddy-covariance measurements. The largest actual LUE was estimated for each site directly as an upper percentile of the ratio of Gross Primary Production (GPP) to absorbed PAR. Potential LUE for each site, on the other hand, was estimated by parameterising a LUE-based production efficiency model (Prelued), which accounts for daily changes in weather (temperature, VPD, PAR). In this model structure, the LUE-parameter for each site, can be interpreted as the potential LUE under optimal environmental conditions, i.e when the environment is not limiting production at all. Averages of the largest actual LUE and potential LUE were higher in deciduous sites than in conifer sites. Canopy mean N correlated weakly with both the largest actual and potential LUE, and the correlation was also significant in conifer subset in the former case. Mean growing season VPD was the only climatic variable which correlated significantly with the largest actual LUE; none of them correlated with potential LUE. Inclusion of nitrogen in the Prelued-model structure did not improve the goodness of fit of the model. According to our results LUE correlates with mean canopy N concentration. The correlation of mean VPD with the largest actual LUE can also be explained with the model accounting for daily variation in climate, as was made with Prelued-model for the potential LUE. Further studies utilising seasonal values of canopy N are called upon. *Acknowledgements: Eero Nikinmaa, Pertti Hari, Timo Vesala, Tuomas Laurila, Fredrik Lagergren, Meelis Mölder, Anders Lindroth, Thomas Grünwald, Christian Bernhofer, Denis Loustau, Paul Berbigier, Beverly Law, Alison Dunn, Steve Wofsy, Torbjörn Johansson, Torben Christensen, Terry Callaghan, Hans Verbeeck, Remko Duursma, Leonardo Montagnani, Dario Papale, Andreas Ibrom, Ebba Dellwik, Kim Pilegaard, Kentaro Takagi, Eva van Gorsel, Heather Keith, Sonia Wharton, Matthias Falk, Kya Tha Paw U, Matt Schroeder, Jon Lloyd

Aircraft measurements of BrO, IO, glyoxal, NO 2, H 2O, O 2–O 2 and aerosol extinction profiles in the tropics: comparison with aircraft-/ship-based in situ and lidar measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Volkamer, Rainer; Baidar, S.; Campos, T. L.

Here, tropospheric chemistry of halogens and organic carbon over tropical oceans modifies ozone and atmospheric aerosols, yet atmospheric models remain largely untested for lack of vertically resolved measurements of bromine monoxide (BrO), iodine monoxide (IO) and small oxygenated hydrocarbons like glyoxal (CHOCHO) in the tropical troposphere. BrO, IO, glyoxal, nitrogen dioxide (NO 2), water vapor (H 2O) and O 2–O 2 collision complexes (O 4) were measured by the University of Colorado Airborne Multi-AXis Differential Optical Absorption Spectroscopy (CU AMAX-DOAS) instrument, aerosol extinction by high spectral resolution lidar (HSRL), in situ aerosol size distributions by an ultra high sensitivity aerosolmore » spectrometer (UHSAS) and in situ H 2O by vertical-cavity surface-emitting laser (VCSEL) hygrometer. Data are presented from two research flights (RF12, RF17) aboard the National Science Foundation/National Center for Atmospheric Research Gulfstream V aircraft over the tropical Eastern Pacific Ocean (tEPO) as part of the "Tropical Ocean tRoposphere Exchange of Reactive halogens and Oxygenated hydrocarbons" (TORERO) project (January/February 2012). We assess the accuracy of O 4 slant column density (SCD) measurements in the presence and absence of aerosols. Our O 4-inferred aerosol extinction profiles at 477 nm agree within 6% with HSRL in the boundary layer and closely resemble the renormalized profile shape of Mie calculations constrained by UHSAS at low (sub-Rayleigh) aerosol extinction in the free troposphere. CU AMAX-DOAS provides a flexible choice of geometry, which we exploit to minimize the SCD in the reference spectrum (SCD REF, maximize signal-to-noise ratio) and to test the robustness of BrO, IO and glyoxal differential SCDs. The RF12 case study was conducted in pristine marine and free tropospheric air. The RF17 case study was conducted above the NOAA RV Ka'imimoana (TORERO cruise, KA-12-01) and provides independent validation data from ship-based in situ cavity-enhanced DOAS and MAX-DOAS. Inside the marine boundary layer (MBL) no BrO was detected (smaller than 0.5 pptv), and 0.2–0.55 pptv IO and 32–36 pptv glyoxal were observed. The near-surface concentrations agree within 30% (IO) and 10% (glyoxal) between ship and aircraft. The BrO concentration strongly increased with altitude to 3.0 pptv at 14.5 km (RF12, 9.1 to 8.6° N; 101.2 to 97.4° W). At 14.5 km, 5–10 pptv NO 2 agree with model predictions and demonstrate good control over separating tropospheric from stratospheric absorbers (NO 2 and BrO). Our profile retrievals have 12–20 degrees of freedom (DoF) and up to 500 m vertical resolution. The tropospheric BrO vertical column density (VCD) was 1.5 × 10 13 molec cm –2 (RF12) and at least 0.5 × 10 13 molec cm –2 (RF17, 0–10 km, lower limit). Tropospheric IO VCDs correspond to 2.1 × 10 12 molec cm –2 (RF12) and 2.5 × 10 12 molec cm –2 (RF17) and glyoxal VCDs of 2.6 × 10 14 molec cm –2 (RF12) and 2.7 × 10 14 molec cm –2 (RF17). Surprisingly, essentially all BrO as well as the dominant IO and glyoxal VCD fraction was located above 2 km (IO: 58 ± 5%, 0.1–0.2 pptv; glyoxal: 52 ± 5%, 3–20 pptv). To our knowledge there are no previous vertically resolved measurements of BrO and glyoxal from aircraft in the tropical free troposphere. The atmospheric implications are briefly discussed. Future studies are necessary to better understand the sources and impacts of free tropospheric halogens and oxygenated hydrocarbons on tropospheric ozone, aerosols, mercury oxidation and the oxidation capacity of the atmosphere.« less

Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects.

PubMed

Krasovitski, Boris; Frenkel, Victor; Shoham, Shy; Kimmel, Eitan

2011-02-22

The purpose of this study was to develop a unified model capable of explaining the mechanisms of interaction of ultrasound and biological tissue at both the diagnostic nonthermal, noncavitational (<100 mW · cm(-2)) and therapeutic, potentially cavitational (>100 mW · cm(-2)) spatial peak temporal average intensity levels. The cellular-level model (termed "bilayer sonophore") combines the physics of bubble dynamics with cell biomechanics to determine the dynamic behavior of the two lipid bilayer membrane leaflets. The existence of such a unified model could potentially pave the way to a number of controlled ultrasound-assisted applications, including CNS modulation and blood-brain barrier permeabilization. The model predicts that the cellular membrane is intrinsically capable of absorbing mechanical energy from the ultrasound field and transforming it into expansions and contractions of the intramembrane space. It further predicts that the maximum area strain is proportional to the acoustic pressure amplitude and inversely proportional to the square root of the frequency (ε A,max ∝ P(A)(0.8f - 0.5) and is intensified by proximity to free surfaces, the presence of nearby microbubbles in free medium, and the flexibility of the surrounding tissue. Model predictions were experimentally supported using transmission electron microscopy (TEM) of multilayered live-cell goldfish epidermis exposed in vivo to continuous wave (CW) ultrasound at cavitational (1 MHz) and noncavitational (3 MHz) conditions. Our results support the hypothesis that ultrasonically induced bilayer membrane motion, which does not require preexistence of air voids in the tissue, may account for a variety of bioeffects and could elucidate mechanisms of ultrasound interaction with biological tissue that are currently not fully understood.

Earthquake Scaling Relations

NASA Astrophysics Data System (ADS)

Jordan, T. H.; Boettcher, M.; Richardson, E.

2002-12-01

Using scaling relations to understand nonlinear geosystems has been an enduring theme of Don Turcotte's research. In particular, his studies of scaling in active fault systems have led to a series of insights about the underlying physics of earthquakes. This presentation will review some recent progress in developing scaling relations for several key aspects of earthquake behavior, including the inner and outer scales of dynamic fault rupture and the energetics of the rupture process. The proximate observations of mining-induced, friction-controlled events obtained from in-mine seismic networks have revealed a lower seismicity cutoff at a seismic moment Mmin near 109 Nm and a corresponding upper frequency cutoff near 200 Hz, which we interpret in terms of a critical slip distance for frictional drop of about 10-4 m. Above this cutoff, the apparent stress scales as M1/6 up to magnitudes of 4-5, consistent with other near-source studies in this magnitude range (see special session S07, this meeting). Such a relationship suggests a damage model in which apparent fracture energy scales with the stress intensity factor at the crack tip. Under the assumption of constant stress drop, this model implies an increase in rupture velocity with seismic moment, which successfully predicts the observed variation in corner frequency and maximum particle velocity. Global observations of oceanic transform faults (OTFs) allow us to investigate a situation where the outer scale of earthquake size may be controlled by dynamics (as opposed to geologic heterogeneity). The seismicity data imply that the effective area for OTF moment release, AE, depends on the thermal state of the fault but is otherwise independent of fault's average slip rate; i.e., AE ~ AT, where AT is the area above a reference isotherm. The data are consistent with β = 1/2 below an upper cutoff moment Mmax that increases with AT and yield the interesting scaling relation Amax ~ AT1/2. Taken together, the OTF relations imply that the seismic productivity for small earthquakes (frequency per unit area) should scale as AT-1/4, which we verify using seismicity catalogs based on both surface-wave and body-wave magnitude. These scaling relations place fundamental constraints on the dynamics of strike-slip faulting on the mid-ocean ridge system.

Strong nonlinear dependence of the spectral amplification factors of deep Vrancea earthquakes magnitude

NASA Astrophysics Data System (ADS)

Marmureanu, Gheorghe; Ortanza Cioflan, Carmen; Marmureanu, Alexandru

2010-05-01

Nonlinear effects in ground motion during large earthquakes have long been a controversial issue between seismologists and geotechnical engineers. Aki wrote in 1993:"Nonlinear amplification at sediments sites appears to be more pervasive than seismologists used to think…Any attempt at seismic zonation must take into account the local site condition and this nonlinear amplification( Local site effects on weak and strong ground motion, Tectonophysics,218,93-111). In other words, the seismological detection of the nonlinear site effects requires a simultaneous understanding of the effects of earthquake source, propagation path and local geological site conditions. The difficulty for seismologists in demonstrating the nonlinear site effects has been due to the effect being overshadowed by the overall patterns of shock generation and path propagation. The researchers from National Institute for Earth Physics ,in order to make quantitative evidence of large nonlinear effects, introduced the spectral amplification factor (SAF) as ratio between maximum spectral absolute acceleration (Sa), relative velocity (Sv) , relative displacement (Sd) from response spectra for a fraction of critical damping at fundamental period and peak values of acceleration(a-max),velocity (v-max) and displacement (d-max),respectively, from processed strong motion record and pointed out that there is a strong nonlinear dependence on earthquake magnitude and site conditions.The spectral amplification factors(SAF) are finally computed for absolute accelerations at 5% fraction of critical damping (β=5%) in five seismic stations: Bucharest-INCERC(soft soils, quaternary layers with a total thickness of 800 m);Bucharest-Magurele (dense sand and loess on 350m); Cernavoda Nuclear Power Plant site (marl, loess, limestone on 270 m) Bacau(gravel and loess on 20m) and Iassy (loess, sand, clay, gravel on 60 m) for last strong and deep Vrancea earthquakes: March 4,1977 (MGR =7.2 and h=95 km);August 30,1986(MGR =7.0 and h=130 km);May 30,1990 (MGR =6.7 and h=90 km) and May 31,1990 (MGR =6.1 and h=87 km). With a view to understand the characteristics of nonlinear soil behavior and the nonlinearity in the seismology and the influence to hazard and risk assessment ,this study examined the ways that nonlinearity would expected to appear on strong motion records made on Romania territory during to last Vrancea earthquake. The effect on nonlinearity is very large. For example, if we maintain the same amplification factor (SAF=5.8942) as for relatively strong earthquake on May 31,1990 with magnitude Ms =6,1 then at Bacau seismic station for earthquake on May 30,1990 (MGR =6.7) the peak acceleration has to be a*max =0.154g( +14.16%) and the actual recorded was only, a max =0.135g. Also, for Vrancea earthquake on August 30,1986, the peak acceleration has to be a*max=0.107g (+45,57%), instead of real value of 0.0736 g recorded at Bacau seismic station. More, the spectral amplification factors(SAF) are function of earthquake magnitude and there is a strong nonlinear dependence of the SAF of earthquake magnitude. The median values of SAF of the last strong Vrancea earthquakes for damping 5% are: 4.16; 3.63 and 3.26 corresponding to May 31,1990 Vrancea earthquake (Ms=6.1),May 30,1990 Vrancea earthquake(Ms=6.7),respectively, August 30,1986 Vrancea one(Ms=7.0). At the same seismic station, for example at Bacau, for 5% damping, SAF for accelerations is 5.22 for May 31,1990 earthquake (Ms =6.1);4.32 for May 30,1990 earthquake (Ms =6.7) and 3,94 for August 30,1986 one (Ms=7.0) etc. Finally, it will be made a comment in connection to U.S. Atomic Energy Commission-Regulatory Guide 1.60 on "Design Response Spectra for seismic design of nuclear power plants " to see spectral amplification factors for deep Vrancea earthquakes are larger and different.

Near infrared fluorescent biliproteins generated from bacteriophytochrome AphB of Nostoc sp. PCC 7120.

PubMed

Yuan, Che; Li, Hui-Zhen; Tang, Kun; Gärtner, Wolfgang; Scheer, Hugo; Zhou, Ming; Zhao, Kai-Hong

2016-04-01

The genome of the cyanobacterium Nostoc sp. PCC 7120 encodes a large number of putative bacteriophytochrome and cyanobacteriochrome photoreceptors that, due to their long-wavelength absorption and fluorescence emission, might serve as fluorescent tags in intracellular investigations. We show that the PAS-GAF domain of the bacteriophytochrome, AphB, binds biliverdin covalently and exhibits, besides its reversible photochemistry, a moderate fluorescence in the near infrared (NIR) spectral region. It was selected for further increasing the brightness while retaining the NIR fluorescence. In the first step, amino acids assumed to improve fluorescence were selectively mutated. The resulting variants were then subjected to several rounds of random mutagenesis and screened for enhanced fluorescence in the NIR. The brightness of optimized PAS-GAF variants increased more than threefold compared to that of wt AphB(1-321), with only insignificant spectral shifts (Amax around 695 nm, and Fmax around 720 nm). In general, the brightness increases with decreasing wavelengths, which allows for a selection of the fluorophore depending on the optical properties of the tissue. A spectral heterogeneity was observed when residue His260, located in close proximity to the chromophore, was mutated to Tyr, emphasizing the strong effects of the environment on the electronic properties of the bound biliverdin chromophore.

Onion and garlic dehydration in the San Emidio Desert, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lund, J.W.; Lienau, P.J.

1994-07-01

Integrated Ingredients dedicated their new onion and garlic processing plant on May 25th. {open_quotes}Grunion{close_quotes} as the new community of 72 employees has been labeled, is located just south of Empire and Gerlach and about 100 miles north of Reno, Nevada. The plant, run by Integrated Ingredients (based in Alameda, CA), is a division of Burns Philp Food, Inc., which owns brands such as Spice Islands, Durkee-French and Fleischmann`s. This plant gives the company the ability to produce its own products for industrial and consumer markets instead of purchasing them. The plant was located in the San Emidio Desert at themore » edge of the vast Black Rock Desert and the Great Basin to take advantage of the high temperature geothermal resource (approximately 270{degrees}F). The resource is also used by the OESI/AMOR II 3.6 MW binary plant about a mile south of the dehydration plant and a gold heap leaching operation just to the north of the plant (Wind Mt. mine operated by AMAX). In addition to the geothermal energy, the high desert is an ideal location for onion and garlic processing because the cold winters kill damaging microbes. Dry winters and summers also help.« less

Gravity current into an ambient fluid with an open surface

NASA Astrophysics Data System (ADS)

Ungarish, Marius

2017-11-01

Consider the steady-state gravity current of height h and density ρ1 that propagates into an ambient motionless fluid of height H and density ρ2 with an upper surface open to the atmosphere (open channel) at high Reynolds number. The current propagates with speed U and causes a depth decrease χ of the top surface. This is a significant extension of Benjamin's (1968) seminal solution for the fixed-top channel χ = 0 . Here the determination of χ is a part of the problem. The dimensionless parameters of the problem are a = h / H and r =ρ2 /ρ1 . We show that a control-volume analysis determines χ = χ / H and Fr = U / (g ' h)1/2 as functions of a , r , where g ' = (r-1 - 1) g is the reduced gravity. The system satisfies balance of volume and momentum (explicitly), and vorticity (implicitly). We present solutions. The predicted flows are in general dissipative, and thus physically valid only for a <=amax (r) 0.5 r where non-negative dissipation appears. The open-surface Fr (a , r) is smaller than Benjamin's Frb (a) , but the reduction is not dramatic, typically a few percent. In the Boussinesq r 1 case, χ << 1 while Fr and dissipation are close to Benjamin's values.

Interaction between the LMWH reviparin and aspirin in healthy volunteers

PubMed Central

Klinkhardt, Ute; Breddin, Hans Klaus; Esslinger, Heinz Ulrich; Haas, Silvia; Kalatzis, Andreas; Harder, Sebastian

2000-01-01

Aims To investigate potential interactions between reviparin and acetylsalicylic acid (ASA 300 mg o.d. from day 1–5). Methods In an open, randomized, three-way-cross over study nine healthy volunteers received reviparin (s.c. injection of 6300 anti-Xa units) or placebo from days 3 to 5 and acetylsalicylic acid (ASA 300 mg) or placebo from days 1 to 5. Assessments included bleeding time (BT), collagen (1 µg ml−1) induced platelet aggregation (CAG), heptest, plasma antifactor Xa-activity and activated partial thromboplastin time (aPTT). Results Median bleeding time at day 5 was 5.5 min after reverparin alone and after ASA alone and was 9.6 min after the combination of reviparin and ASA. ASA treatment reduced CAG from 84% to 40 to 50% of Amax; values after combined treatment of reviparin with ASA were not different from those after ASA alone. aPTT was prolonged to 32 s after reviparin; this effect was not modified if subjects received ASA. Combined treatment with ASA and reviparin had no effect on plasma anti-Xa-activity and heptest compared with reviparin alone. Conclusions We could not entirely exclude a small interaction between reviparin and ASA on bleeding time, but the effect is probably without clinical significance. PMID:10759689

Growth synchrony between leaves and stems during twig development differs among plant functional types of subtropical rainforest woody species.

PubMed

Meng, Fengqun; Zhang, Guangfu; Li, Xincheng; Niklas, Karl J; Sun, Shucun

2015-06-01

During the development of woody twigs, the growth in leaf may or may not be proportional to the growth in stem. The presence or absence of a synchronicity between these two phenologies may reflect differences in life history adaptive strategies concerning carbon gain. We hypothesized that sun-adapted species are more likely to be less synchronous between growths in total leaf area (TLA) and stem length compared with shade-adapted species, with a bias in growth in stem length, and that shade-adapted species are more likely to be more synchronous between increases in individual leaf area (ILA) (leaf size) and leaf number (LN) during twig development compared with sun-adapted species, giving priority to growth of leaf size. We tested these two hypotheses by recording the phenologies of leaf emergence, leaf expansion and stem elongation during twig development for 19 evergreen woody species (including five shade-adapted understory species, six sun-adapted understory species and eight sun-adapted canopy species) in a subtropical evergreen broad-leaved forest in eastern China. We constructed indices to characterize the synchronicity between TLA and stem length (αLS) and between leaf size and leaf number (αSN) and we derived the α values from logistic functions taking the general form of A = A(max)/[1 + exp(β - αB)] (where A is the TLA or average ILA, B is the corresponding stem length or LN at a specific time, and A(max) is the maximum TLA or the maximum ILA of a twig; the higher the numerical value of α, the less synchronous the corresponding phenologies). Consistent with our hypotheses, sun-adapted species were higher both in α(LS) and α(SN), showing less synchronous patterns in the growths of TLA vs stem length and leaf size vs LN during twig development. Moreover, α(LS) and α(SN) were significantly positively correlated with relative growth rates of LN and leaf size across species, as indicated by both analyses of ordinary regression and phylogenetic generalized least squares. The across-species synchronies during twig development show that the temporal dynamics of the leaf size-twig size spectrum is of adaptive significance in plants. We suggest that temporal dynamics of plant functional traits should be extensively studied to characterize plant life history. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Analysis of WBV on standing and seated passengers during off-peak operation in KL monorail

NASA Astrophysics Data System (ADS)

Hasnan, K.; Bakhsh, Q.; Ahmed, A.; Ali, D.; Jamali, A. R.

2018-03-01

In this study, the Whole-Body Vibration (WBV) was analyzed on the standing and seated passenger during off-peak operating hours when train was on the track. The experiments were conducted on two car train at one constant location (bogie-1, which is near to driver’s cabin) during downward direction from KL sentral station towards Titiwangsa station. The aim of this study was to analyze that, in which posture of passenger’s exposures the maximum level of WBV. Since, one passenger was performed the whole journey in standing posture whereas, the other passenger was in seated posture. The result obtained from experiments for the RMS accelerations (Arms), maximum acceleration (Amax) and minimum acceleration (Amin) during the trip. As per standard ISO 2631-1, the daily vibration exposure (A8), Vibration Dose value (VDV) and Crest Factor (CF) of this trip for both standing and sitting orientations were calculated. Results shows that the seated passenger was exposed to longer periods of continuous vibration as compared to the standing passenger. Whereas, the Vibration Dose value (VDV) value was greater than the action value as per ISO 2631-1 and within the limit values. The study concluded that whole body vibration transmitted towards both passengers either standing or seated during their journey. But in overall results comparison of both orientations, the seated passengers gained higher vibration than the standing one.

Low-temperature (10°C) anaerobic digestion of dilute dairy wastewater in an EGSB bioreactor: microbial community structure, population dynamics, and kinetics of methanogenic populations.

PubMed

Bialek, Katarzyna; Cysneiros, Denise; O'Flaherty, Vincent

2013-01-01

The feasibility of anaerobic digestion of dairy wastewater at 10°C was investigated in a high height : diameter ratio EGSB reactor. Stable performance was observed at an applied organic loading rate (OLR) of 0.5-2 kg COD m(-3) d(-1) with chemical oxygen demand (COD) removal efficiencies above 85%. When applied OLR increased to values above 2 kg COD m(-3) d(-1), biotreatment efficiency deteriorated, with methanogenesis being the rate-limiting step. The bioreactor recovered quickly (3 days) after reduction of the OLR. qPCR results showed a reduction in the abundance of hydrogenotrophic methanogenic Methanomicrobiales and Methanobacteriales throughout the steady state period followed by a sharp increase in their numbers (111-fold) after the load shock. Specific methanogenic activity and maximum substrate utilising rate (A(max)) of the biomass at the end of trial indicated increased activity and preference towards hydrogenotrophic methanogenesis, which correlated well with the increased abundance of hydrogenotrophic methanogens. Acetoclastic Methanosaeta spp. remained at stable levels throughout the trial. However, increased apparent half-saturation constant (K(m)) at the end of the trial indicated a decrease in the specific substrate affinity for acetate of the sludge, suggesting that Methanosaeta spp., which have high substrate affinity, started to be outcompeted in the reactor.

Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension.

PubMed

Banek, Christopher T; Knuepfer, Mark M; Foss, Jason D; Fiege, Jessica K; Asirvatham-Jeyaraj, Ninitha; Van Helden, Dusty; Shimizu, Yoji; Osborn, John W

2016-12-01

Renal sympathetic denervation (RDNx) has emerged as a novel therapy for hypertension; however, the therapeutic mechanisms remain unclear. Efferent renal sympathetic nerve activity has recently been implicated in trafficking renal inflammatory immune cells and inflammatory chemokine and cytokine release. Several of these inflammatory mediators are known to activate or sensitize afferent nerves. This study aimed to elucidate the roles of efferent and afferent renal nerves in renal inflammation and hypertension in the deoxycorticosterone acetate (DOCA) salt rat model. Uninephrectomized male Sprague-Dawley rats (275-300 g) underwent afferent-selective RDNx (n=10), total RDNx (n=10), or Sham (n=10) and were instrumented for the measurement of mean arterial pressure and heart rate by radiotelemetry. Rats received 100-mg DOCA (SC) and 0.9% saline for 21 days. Resting afferent renal nerve activity in DOCA and vehicle animals was measured after the treatment protocol. Renal tissue inflammation was assessed by renal cytokine content and T-cell infiltration and activation. Resting afferent renal nerve activity, expressed as a percent of peak afferent nerve activity, was substantially increased in DOCA than in vehicle (35.8±4.4 versus 15.3±2.8 %Amax). The DOCA-Sham hypertension (132±12 mm Hg) was attenuated by ≈50% in both total RDNx (111±8 mm Hg) and afferent-selective RDNx (117±5 mm Hg) groups. Renal inflammation induced by DOCA salt was attenuated by total RDNx and unaffected by afferent-selective RDNx. These data suggest that afferent renal nerve activity may mediate the hypertensive response to DOCA salt, but inflammation may be mediated primarily by efferent renal sympathetic nerve activity. Also, resting afferent renal nerve activity is elevated in DOCA salt rats, which may highlight a crucial neural mechanism in the development and maintenance of hypertension. © 2016 American Heart Association, Inc.

Concept and properties of an infrared hybrid single-beam spectrum and its application to eliminate solvent bands and other background interferences.

PubMed

Chen, Yujing; Wang, Hai-Shui; Morisawa, Yusuke; Ozaki, Yukihiro

2014-02-01

For infrared (IR) spectral measurements, if a quality single-beam background spectrum with desired intensity could be obtained, the contributions from solvent and other background components could be completely suppressed and their bands would not appear in a final transmittance/absorbance spectrum. In order to achieve this ideal but difficult goal, the concept of hybrid single-beam spectrum is introduced in this paper. The hybrid single-beam spectrum (φ h) is defined as a mixture of two single-beam spectra (φ b1 and φ b2) of the same sample but with different pathlengths (b1 and b2), namely, φ h = αφ b1+(1-α)φ b2, where α (0 ≤ α ≤ 1) is the component factor. The properties of the hybrid spectrum have been investigated. Under conditions of b2 > b1 ≥ 0.7 b2 and A max ≤ 0.60 (Amax is the maximum absorbance of b2 sample in the spectral range of interest), all the synthesized hybrid spectra are free from significant distortion regardless of the component factor. Therefore, the hybrid single-beam spectrum with desired intensity can be easily obtained simply by choosing an appropriate component factor. The proposed methodology has been demonstrated experimentally by the complete removal of the interference from the atmospheric water vapor and solvent. © 2013 Elsevier B.V. All rights reserved.

Dependence of cancer cell adhesion kinetics on integrin ligand surface density measured by a high-throughput label-free resonant waveguide grating biosensor.

PubMed

Orgovan, Norbert; Peter, Beatrix; Bősze, Szilvia; Ramsden, Jeremy J; Szabó, Bálint; Horvath, Robert

2014-02-07

A novel high-throughput label-free resonant waveguide grating (RWG) imager biosensor, the Epic® BenchTop (BT), was utilized to determine the dependence of cell spreading kinetics on the average surface density (v(RGD)) of integrin ligand RGD-motifs. v(RGD) was tuned over four orders of magnitude by co-adsorbing the biologically inactive PLL-g-PEG and the RGD-functionalized PLL-g-PEG-RGD synthetic copolymers from their mixed solutions onto the sensor surface. Using highly adherent human cervical tumor (HeLa) cells as a model system, cell adhesion kinetic data of unprecedented quality were obtained. Spreading kinetics were fitted with the logistic equation to obtain the spreading rate constant (r) and the maximum biosensor response (Δλmax), which is assumed to be directly proportional to the maximum spread contact area (Amax). r was found to be independent of the surface density of integrin ligands. In contrast, Δλmax increased with increasing RGD surface density until saturation at high densities. Interpreting the latter behavior with a simple kinetic mass action model, a 2D dissociation constant of 1753 ± 243 μm(-2) (corresponding to a 3D dissociation constant of ~30 μM) was obtained for the binding between RGD-specific integrins embedded in the cell membrane and PLL-g-PEG-RGD. All of these results were obtained completely noninvasively without using any labels.

Copigmentation Of Anthocyanin Extract of Purple Sweet Potatoes (Ipomea Batatas L.) Using Ferulic Acid And Tannic Acid

NASA Astrophysics Data System (ADS)

Susanti, I.; Wijaya, H.; Hasanah, F.; Heryani, S.

2018-02-01

Copigmentation is one of the methods to improve the color stability and intensity of anthocyanin extract. This study aimed to do the copigmentation of the anthocyanin extract of purple sweet potato using ferulic acid and tannic acid. The anthocyanin extraction was conducted with distilled water at pH 7 and pH 2 while the copigmentation was conducted by varying the concentration of ferulic acid and tannic acid. The results showed that best anthocyanin extraction method of the purple sweet potato was using distilled water at pH 2. The yield of freeze dried anthocyanin on the extraction with distilled water at pH 2 was 1710 ppm, while the yield when using distilled water at pH 7 was 888 ppm. Ferulic acid and tannic acid can be used for the copigmentation of anthocyanin extract of purple sweet potato by observing the maximum wavelength shift (bathochromic effect, Δλmax) and increase of color intensity (hyperchromic effect, ΔAmax). The bathochromic effect of ferulic acid began to occur at a concentration of 0.01M, while the hypochromic effect on tannic acid occurred at a concentration of 0.005M and remained up to a concentration of 0.02M. The best copigmentation concentration of ferulic acid was 0.015M, while tannic acid was 0.02M. The use of tannic acid 0.02M is recommended compared to ferulic acid 0.015M because with the same bathocromic effect (Δλmaks = 3,9) results hyperchromic effect (ΔA = 0,258) higher by tannic acid.

Effects of carbohydrate accumulation on photosynthesis differ between sink and source leaves of Phaseolus vulgaris L.

PubMed

Araya, Takao; Noguchi, Ko; Terashima, Ichiro

2006-05-01

Accumulation of non-structural carbohydrate in leaves represses photosynthesis. However, the extent of repression should be different between sink leaves (sugar consumers) and source leaves (sugar exporters). We investigated the effects of carbohydrate accumulation on photosynthesis in the primary leaves of bean (Phaseolus vulgaris L.) during leaf expansion. To increase the carbohydrate content of the leaves, we supplied 20 mM sucrose solution to the roots for 5 d (sugar treatment). Plants supplied only with water and nutrients were used as controls. The carbohydrate contents, which are the sum of glucose, sucrose and starch, of the sugar-treated leaves were 1.5-3 times of those of the control leaves at all developmental stages. In the young sink leaves, the photosynthetic rate at saturating light and at an ambient CO2 concentration (A360) did not differ between the sugar-treated and control leaves. The A360 of sugar-treated source leaves gradually decreased relative to the control source leaves with leaf expansion. The initial slope of the A-Ci (CO2 concentration in the intercellular space) curve, and the Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase) content per leaf area showed trends similar to that of A360. Differences in Amax between the treatments were slightly smaller than those in A360. These results indicate that the effect of carbohydrate accumulation on photosynthesis is significant in the source leaves, but not in the young sink leaves, and that the decrease in Rubisco content was the main cause of the carbohydrate repression of photosynthesis.

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of Attention Deficit Hyperactivity Disorder

PubMed Central

Somkuwar, Sucharita S.; Kantak, Kathleen M.; Dwoskin, Linda P.

2015-01-01

Attention Deficit Hyperactivity Disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also reduces ADHD-like symptoms in Spontaneously Hypertensive Rats (SHRs), a model of ADHD. However, effects of chronic MPH treatment on NET function in mPFC and OFC in SHR have not been reported. In the current study, long-term effects of repeated treatment with a therapeutically relevant oral dose of MPH during adolescence on NET function in subregions of mPFC (cingulate gyrus, prelimbic cortex and infralimbic cortex) and in the OFC of adult SHR, Wistar-Kyoto (WKY, inbred control) and Wistar (WIS, outbred control) rats were determined using in vivo voltammetry. Following local ejection of norepinephrine (NE), uptake rate was determined as peak amplitude (Amax) x first-order rate constant (k-1). In mPFC subregions, no strain or treatment effects were found in NE uptake rate. In OFC, NE uptake rate in vehicle-treated adult SHR was greater than in adult WKY and WIS administered vehicle. MPH treatment during adolescence normalized NE uptake rate in OFC in SHR. Thus, the current study implicates increased NET function in OFC as an underlying mechanism for reduced noradrenergic transmission in OFC, and consequently, the behavioral deficits associated with ADHD. MPH treatment during adolescence normalized NET function in OFC in adulthood, suggesting that the therapeutic action of MPH persists long after treatment cessation and may contribute to lasting reductions in deficits associated with ADHD. PMID:25680322

Lack of photosynthetic or stomatal regulation after 9 years of elevated [CO2] and 4 years of soil warming in two conifer species at the alpine treeline.

PubMed

Streit, Kathrin; Siegwolf, Rolf T W; Hagedorn, Frank; Schaub, Marcus; Buchmann, Nina

2014-02-01

Alpine treelines are temperature-limited vegetation boundaries. Understanding the effects of elevated [CO2 ] and warming on CO2 and H2 O gas exchange may help predict responses of treelines to global change. We measured needle gas exchange of Larix decidua Mill. and Pinus mugo ssp. uncinata DC trees after 9 years of free air CO2 enrichment (575 µmol mol(-1) ) and 4 years of soil warming (+4 °C) and analysed δ(13) C and δ(18) O values of needles and tree rings. Tree needles under elevated [CO2 ] showed neither nitrogen limitation nor end-product inhibition, and no down-regulation of maximal photosynthetic rate (Amax ) was found. Both tree species showed increased net photosynthetic rates (An ) under elevated [CO2 ] (L. decidua: +39%; P. mugo: +35%). Stomatal conductance (gH2O ) was insensitive to changes in [CO2 ], thus transpiration rates remained unchanged and intrinsic water-use efficiency (iWUE) increased due to higher An . Soil warming affected neither An nor gH2O . Unresponsiveness of gH2O to [CO2 ] and warming was confirmed by δ(18) O needle and tree ring values. Consequently, under sufficient water supply, elevated [CO2 ] induced sustained enhancement in An and lead to increased C inputs into this ecosystem, while soil warming hardly affected gas exchange of L. decidua and P. mugo at the alpine treeline. © 2013 John Wiley & Sons Ltd.

Divergence in Eco-Physiological Responses to Drought Mirrors the Distinct Distribution of Chamerion angustifolium Cytotypes in the Himalaya–Hengduan Mountains Region

PubMed Central

Guo, Wen; Yang, Jie; Sun, Xu-Dong; Chen, Guang-Jie; Yang, Yong-Ping; Duan, Yuan-Wen

2016-01-01

Polyploid species generally occupy harsher habitats (characterized by cold, drought and/or high altitude) than diploids, but the converse was observed for Chamerion angustifolium, in which diploid plants generally inhabit higher altitudes than their polyploid derivatives. Plants at high altitudes may experience cold-induced water stress, and we therefore examined the physiological responses of diploid and hexaploid C. angustifolium to water stress to better understand the ecological differentiation of plants with different ploidy levels. We conducted a common garden experiment by subjecting seedlings of different ploidy levels to low, moderate, and severe water stress. Fourteen indicators of physiological fitness were measured, and the anatomical characteristics of the leaves of each cytotype were determined. Both cytotypes were influenced by drought, and diploids exhibited higher fitness in terms of constant root:shoot ratio (R:S ratio) and maximum quantum yield of PS II (Fv/Fm), less reduced maximal photosynthetic rate (Amax), transpiration rate (E), intercellular CO2 concentration (Ci) and stomatal conductance (gs), and higher long-term water use efficiency (WUEL) under severe water stress than did hexaploids. Analysis of leaf anatomy revealed morphological adjustments for tolerating water deficiency in diploids, in the form of closely packed mesophyll cells and small conduits in the midvein. Our results indicate that diploid C. angustifolium is more tolerant of drought than hexaploid plants, ensuring the successful survival of the diploid at high altitudes. This eco-physiological divergence may facilitate the species with different cytotypes to colonize new and large geographic ranges with heterogeneous environmental conditions. PMID:27630654

OGLE-2003-BLG-238: Microlensing Mass Estimate of an Isolated Star

NASA Astrophysics Data System (ADS)

Jiang, Guangfei; DePoy, D. L.; Gal-Yam, A.; Gaudi, B. S.; Gould, A.; Han, C.; Lipkin, Y.; Maoz, D.; Ofek, E. O.; Park, B.-G.; Pogge, R. W.; MuFun Collaboration; Udalski, A.; Kubiak, M.; Szymański, M. K.; Szewczyk, O.; Żebruń, K.; Wyrzykowski, Ł.; Soszyński, I.; Pietrzyński, G.; OGLE Collaboration; Albrow, M. D.; Beaulieu, J.-P.; Caldwell, J. A. R.; Cassan, A.; Coutures, C.; Dominik, M.; Donatowicz, J.; Fouqué, P.; Greenhill, J.; Hill, K.; Horne, K.; Jørgensen, S. F.; Jørgensen, U. G.; Kane, S.; Kubas, D.; Martin, R.; Menzies, J.; Pollard, K. R.; Sahu, K. C.; Wambsganss, J.; Watson, R.; Williams, A.; PLANET Collaboration

2004-12-01

Microlensing is the only known direct method to measure the masses of stars that lack visible companions. In terms of microlensing observables, the mass is given by M=(c2/4G)rEθE and so requires the measurement of both the angular Einstein radius θE and the projected Einstein radius rE. Simultaneous measurement of these two parameters is extremely rare. Here we analyze OGLE-2003-BLG-238, a spectacularly bright (Imin=10.3), high-magnification (Amax=170) microlensing event. Pronounced finite-source effects permit a measurement of θE=650μas. Although the timescale of the event is only tE=38days, one can still obtain weak constraints on the microlens parallax: 4.4AU

Leaf gas exchange of understory spruce-fir saplings in relict cloud forests, southern Appalachian Mountains, USA.

PubMed

Reinhardt, Keith; Smith, William K

2008-01-01

The southern Appalachian spruce-fir (Picea rubens Sarg. and Abies fraseri (Pursh) Poir.) forest is found only on high altitude mountain tops that receive copious precipitation ( > 2000 mm year(-1)) and experience frequent cloud immersion. These high-elevation, temperate rain forests are immersed in clouds on approximately 65% of the total growth season days and for 30-40% of a typical summer day, and cloud deposition accounts for up to 50% of their annual water budget. We investigated environmental influences on understory leaf gas exchange and water relations at two sites: Mt. Mitchell, NC (MM; 35 degrees 45'53'' N, 82 degrees 15'53'' W, 2028 m elevation) and Whitetop Mtn., VA (WT; 36 degrees 38'19'' N, 81 degrees 36'19'' W, 1685 m elevation). We hypothesized that the cool, moist and cloudy conditions at these sites exert a strong influence on leaf gas exchange. Maximum photosynthesis (A(max)) varied between 1.6 and 4.0 micromol CO(2) m(-2) s(-1) for both spruce and fir and saturated at irradiances between approximately 200 and 400 micromol m(-2) s(-1) at both sites. Leaf conductance (g) ranged between 0.05 and 0.25 mol m(-2) s(-1) at MM and between 0.15 and 0.40 mol m(-2) s(-1) at WT and was strongly associated with leaf-to-air vapor pressure difference (LAVD). At both sites, g decreased exponentially as LAVD increased, with an 80-90% reduction in g between 0 and 0.5 kPa. Predawn leaf water potentials remained between -0.25 and -0.5 MPa for the entire summer, whereas late afternoon values declined to between -1.25 and -1.75 MPa by late summer. Thus, leaf gas exchange appeared tightly coupled to the response of g to LAVD, which maintained high water status, even at the relatively low LAVD of these cloud forests. Moreover, the cloudy, humid environment of these refugial forests appears to exert a strong influence on tree leaf gas exchange and water relations. Because global climate change is predicted to increase regional cloud ceiling levels, more research on cloud impacts on carbon gain and water relations is needed to predict future impacts on these relict forests.

Height-related changes in leaf photosynthetic traits in diverse Bornean tropical rain forest trees.

PubMed

Kenzo, Tanaka; Inoue, Yuta; Yoshimura, Mitsunori; Yamashita, Megumi; Tanaka-Oda, Ayumi; Ichie, Tomoaki

2015-01-01

Knowledge of variations in morphophysiological leaf traits with forest height is essential for quantifying carbon and water fluxes from forest ecosystems. Here, we examined changes in leaf traits with forest height in diverse tree species and their role in environmental acclimation in a tropical rain forest in Borneo that does not experience dry spells. Height-related changes in leaf physiological and morphological traits [e.g., maximum photosynthetic rate (Amax), stomatal conductance (gs), dark respiration rate (Rd), carbon isotope ratio (δ(13)C), nitrogen (N) content, and leaf mass per area (LMA)] from understory to emergent trees were investigated in 104 species in 29 families. We found that many leaf area-based physiological traits (e.g., A(max-area), Rd, gs), N, δ(13)C, and LMA increased linearly with tree height, while leaf mass-based physiological traits (e.g., A(max-mass)) only increased slightly. These patterns differed from other biomes such as temperate and tropical dry forests, where trees usually show decreased photosynthetic capacity (e.g., A(max-area), A(max-mass)) with height. Increases in photosynthetic capacity, LMA, and δ(13)C are favored under bright and dry upper canopy conditions with higher photosynthetic productivity and drought tolerance, whereas lower R d and LMA may improve shade tolerance in lower canopy trees. Rapid recovery of leaf midday water potential to theoretical gravity potential during the night supports the idea that the majority of trees do not suffer from strong drought stress. Overall, leaf area-based photosynthetic traits were associated with tree height and the degree of leaf drought stress, even in diverse tropical rain forest trees.

Trends in hydrological extremes in the Senegal and the Niger Rivers

NASA Astrophysics Data System (ADS)

Wilcox, C.; Bodian, A.; Vischel, T.; Panthou, G.; Quantin, G.

2017-12-01

In recent years, West Africa has witnessed several floods of unprecedented magnitude. Although the evolution of hydrological extremes has been evaluated in the region to some extent, results lack regional coverage, significance levels, uncertainty estimations, model selection criteria, or a combination of the above. In this study, Generalized Extreme Value (GEV) distributions with and without various non-stationary temporal covariates are applied to annual maxima of daily discharge (AMAX) data sets in the Sudano-Guinean part of the Senegal River basin and in the Sahelian part of the Niger River basin. The data ranges from the 1950s to the 2010s. The two models of best fit most often selected (with an alpha=0.05 certainty level) were 1) a double-linear model for the central tendency parameter (μ) with stationary dispersion (σ) and 2) a double-linear model for both parameters. Change points are relatively consistent for the Senegal basin, with stations switching from a decreasing streamflow trend to an increasing streamflow trend in the early 1980s. In the Niger basin the trend in μ was generally positive with an increase in slope after the change point, but the change point location was less consistent. The study clearly demonstrates the significant trends in extreme discharge values in West Africa over the past six decades. Moreover, it proposes a clear methodology for comparing GEV models and selecting the best for use. The return levels generated from the chosen models can be applied to river basin management and hydraulic works sizing. The results provide a first evaluation of non-stationarity in extreme hydrological values in West Africa that is accompanied by significance levels, uncertainties, and non-stationary return level estimations .

Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction*

PubMed Central

Pradhan, Madhumita A.; Blackford, John A.; Devaiah, Ballachanda N.; Thompson, Petria S.; Chow, Carson C.; Singer, Dinah S.; Simons, S. Stoney

2016-01-01

Most of the steps in, and many of the factors contributing to, glucocorticoid receptor (GR)-regulated gene induction are currently unknown. A competition assay, based on a validated chemical kinetic model of steroid hormone action, is now used to identify two new factors (BRD4 and negative elongation factor (NELF)-E) and to define their sites and mechanisms of action. BRD4 is a kinase involved in numerous initial steps of gene induction. Consistent with its complicated biochemistry, BRD4 is shown to alter both the maximal activity (Amax) and the steroid concentration required for half-maximal induction (EC50) of GR-mediated gene expression by acting at a minimum of three different kinetically defined steps. The action at two of these steps is dependent on BRD4 concentration, whereas the third step requires the association of BRD4 with P-TEFb. BRD4 is also found to bind to NELF-E, a component of the NELF complex. Unexpectedly, NELF-E modifies GR induction in a manner that is independent of the NELF complex. Several of the kinetically defined steps of BRD4 in this study are proposed to be related to its known biochemical actions. However, novel actions of BRD4 and of NELF-E in GR-controlled gene induction have been uncovered. The model-based competition assay is also unique in being able to order, for the first time, the sites of action of the various reaction components: GR < Cdk9 < BRD4 ≤ induced gene < NELF-E. This ability to order factor actions will assist efforts to reduce the side effects of steroid treatments. PMID:26504077

Photosynthetic Light Responses May Explain Vertical Distribution of Hymenophyllaceae Species in a Temperate Rainforest of Southern Chile.

PubMed

Parra, María José; Acuña, Karina I; Sierra-Almeida, Angela; Sanfuentes, Camila; Saldaña, Alfredo; Corcuera, Luis J; Bravo, León A

2015-01-01

Some epiphytic Hymenophyllaceae are restricted to lower parts of the host (< 60 cm; 10-100 μmol photons m(-2) s(-1)) in a secondary forest of Southern Chile; other species occupy the whole host height (≥ 10 m; max PPFD > 1000 μmol photons m(-2) s(-1)). Our aim was to study the photosynthetic light responses of two Hymenophyllaceae species in relation to their contrasting distribution. We determined light tolerance of Hymenoglossum cruentum and Hymenophyllum dentatum by measuring gas exchange, PSI and PSII light energy partitioning, NPQ components, and pigment contents. H. dentatum showed lower maximum photosynthesis rates (A max) than H. cruentum, but the former species kept its net rates (An) near Amax across a wide light range. In contrast, in the latter one, An declined at PPFDs > 60 μmol photons m(-2) s(-1). H. cruentum, the shadiest plant, showed higher chlorophyll contents than H. dentatum. Differences in energy partitioning at PSI and PSII were consistent with gas exchange results. H. dentatum exhibited a higher light compensation point of the partitioning of absorbed energy between photochemical Y(PSII) and non-photochemical Y(NPQ) processes. Hence, both species allocated energy mainly toward photochemistry instead of heat dissipation at their light saturation points. Above saturation, H. cruentum had higher heat dissipation than H. dentatum. PSI yield (YPSI) remained higher in H. dentatum than H. cruentum in a wider light range. In both species, the main cause of heat dissipation at PSI was a donor side limitation. An early dynamic photo-inhibition of PSII may have caused an over reduction of the Qa+ pool decreasing the efficiency of electron donation to PSI. In H. dentatum, a slight increase in heat dissipation due to acceptor side limitation of PSI was observed above 300 μmol photons m(-2)s(-1). Differences in photosynthetic responses to light suggest that light tolerance and species plasticity could explain their contrasting vertical distribution.

[Effect of air temperature and rainfall on wetland ecosystem CO2 exchange in China].

PubMed

Chu, Xiao-jing; Han, Guang-xuan

2015-10-01

Wetland can be a potential efficient sink to reduce global warming due to its higher primary productivity and lower carbon decomposition rate. While there has been a series progress on the influence mechanism of ecosystem CO2 exchange over China' s wetlands, a systematic metaanalysis of data still needs to be improved. We compiled data of ecosystem CO2 exchange of 21 typical wetland vegetation types in China from 29 papers and carried out an integrated analysis of air temperature and precipitation effects on net ecosystem CO2 exchange (NEE), ecosystem respiration (Reco), gross primary productivity (GPP), the response of NEE to PAR, and the response of Reco to temperature. The results showed that there were significant responses (P<0.05) of NEE (R2 = 50%, R2=57%), GPP (R2 = 60%, R2 = 50%) Reco (R2 = 44%, R2=50%) with increasing air temperature and enhanced precipitation on the annual scale. On the growing season scale, air temperature accounted for 50% of the spatial variation of NEE, 36% of GPP and 19% of Reco, respectively. Both NEE (R2 = 33%) and GPP (R2 =25%) were correlated positively with precipitation (P<0.05). However, the relationship between Reco and precipitation was not significant (P>0.05). Across different Chinese wetlands, both precipitation and temperature had no significant effect on apparent quantum yield (α) or ecosystem respiration in the daytime (Reco,day, P>0.05). The maximum photosynthesis rate (Amax) was remarkably correlated with precipitation (P <0.01), but not with air temperature. Besides, there was no significant correlation between basal respiration (Rref) and precipitation (P>0.05). Precipitation was negatively correlated with temperature sensitivity of Reco (Q10, P<0.05). Furthermore, temperature accounted for 35% and 46% of the variations in temperature sensitivity of Reco (Q10) and basal respiration (Rref P<0.05), respectively.

Asteroid spin and shape modelling using two lightcurve inversion methods

NASA Astrophysics Data System (ADS)

Marciniak, Anna; Bartczak, Przemyslaw; Konstanciak, Izabella; Dudzinski, Grzegorz; Mueller, Thomas G.; Duffard, Rene

2016-10-01

We are conducting an observing campaign to counteract strong selection effects in photometric studies of asteroids. Our targets are long-period (P>12 hours) and low-amplitude (a_max<0.25 mag) asteroids, that although numerous, have poor lightcurve datasets (Marciniak et al. 2015, PSS 118, 256). As a result such asteroids are very poorly studied in terms of their spins and shapes. Our campaign targets a sample of around 100 bright (H<11 mag) main belt asteroids sharing both of these features, resulting in a few tens of new composite lightcurves each year. At present the data gathered so far allowed to construct detailed models for the shape and spin for about ten targets.In this study we perform spin and shape modelling using two lightcurve inversion methods: convex inversion (Kaasalainen et al. 2001, Icarus, 153, 37) and nonconvex SAGE modelling algorithm (Shaping Asteroids with Genetic Evolution, Bartczak et al. 2014, MNRAS, 443, 1802). These two methods are independent from each other, and are based on different assumptions for the shape.Thus, the results obtained on the same datasets provide a cross-check of both the methods and the resulting spin and shape models. The results for the spin solutions are highly consistent, and the shape models are similar, though the ones from SAGE algorithm provide more details of the surface features. Nonconvex shape produced by SAGE have been compared with direct images from spacecrafts and the first results for targets like Eros or Lutetia (Batczak et al. 2014, ACM conf. 29B) provide a high level of agreement.Another way of validation is the shape model comparison with the asteroid shape contours obtained using different techniques (like the stellar occultation timings or adaptive optics imaging) or against data in thermal infrared range gathered by ground and space-bound observatories. The thermal data could provide assignment of size and albedo, but also can help to resolve spin-pole ambiguities. In special cases, the thermal data from Spitzer and Wise/NEOWise might even help in testing specific shape features via thermal infrared lightcurves.

Phenology of seed and leaves rain in response to periodic climatic variability in a seasonal wet tropical forest

NASA Astrophysics Data System (ADS)

Matteo, D.; Wright, S. J.; Davies, S. J.; Muller-Landau, H. C.; Wolfe, B.; Detto, M.

2016-12-01

Phenology, by controlling the rhythms of plants, plays a fundamental role in regulating access to resources, ecosystem processes, competition among species, interactions with consumers and feedbacks to the climate. In high biodiverse tropical forests, where phenology of flowering and leafing are complex, an adequate representation of phenology must take into account a given set of climatic, edaphic and biotic factors. Climatic factors are particularly important because plants may use them as cues for timing different phenological phases and be influenced by their intensity. Climatic variability can be periodic, if events occur with regular frequency, or aperiodic. One prominent periodic large-scale pattern that causes unusual weather is ENSO event. In general, Central America tends to be dry and warm during a mature phase of an ENSO event, which usually peaks between October and January with a frequency of 2-3 events per decade. Because in many tropical areas the effect of ENSO is highly prominent, it is plausible that plants have adapted their growth and reproduction mechanisms to synchronize ENSO phases, in a similar way that plants do during the seasonal cycle. We used a long dataset (30+ years) of fruits and leaves rains of tropical trees and lianas to determine ecosystem response and species specific response of these phenological events to local climate variability corresponding to the modes of ENSO. Specifically, we tested the hypothesis that phenological responses to ENSO are similar to response to seasonal cycles, i.e., higher litterfall before a warm-dry phase and higher fruiting after such phase, with strong correlation between seeds and leaves. At sub-community level, we evaluated whether evergreen and deciduous, biotic and abiotic dispersers and free and climbing life forms, have the same response to ENSO in terms of leaves and seeds rain. At species level we tested the hypothesis that species with low photosynthetic capacity leaves are more responsive to ENSO in relation to variation in solar radiation. High Amax is usually associated with light-demanding, fast growing, gap species. These species must disperse seeds to ephemeral gaps to germinate successfully. Consequently they strategize to have more even seed fall across years

The disastrous effects of salt dust deposition on cotton leaf photosynthesis and the cell physiological properties in the Ebinur Basin in Northwest China.

PubMed

Abuduwaili, Jilili; Zhaoyong, Zhang; Feng qing, Jiang; Dong wei, Liu

2015-01-01

Salt dust in rump lake areas in arid regions has long been considered an extreme stressor for both native plants and crops. In recent years, research on the harmful effects of salt dust on native plants has been published by many scholars, but the effect on crops has been little studied. In this work, in order to determine the impact of salt dust storms on cotton, we simulated salt dust exposure of cotton leaves in Ebinur Basin in Northwest China, and measured the particle sizes and salt ions in the dust, and the photosynthesis, the structure and the cell physiological properties of the cotton leaves. (1) Analysis found that the salt ions and particle sizes in the salt dust used in the experiments were consistent with the natural salt dust and modeled the salt dust deposition on cotton leaves in this region. (2) The main salt cations on the surface and inside the cotton leaves were Na+, Ca2+, Cl- and SO42-, while the amounts of CO3- and HCO3- were low. From the analysis, we can order the quantity of the salt cations and anions ions present on the surface and inside the cotton leaves as Na+>Ca2+>Mg2+>K+ and Cl->SO42->HCO3->CO3-, respectively. Furthermore, the five salt dust treatment groups in terms of the total salt ions on both the surface and inside the cotton leaves were A(500g.m-2)>B(400g.m-2)>C(300g.m-2)>D(200g.m-2)>E(100g.m-2)>F(0g.m-2). (3)The salt dust that landed on the surface of the cotton leaves can significantly influence the photosynthetic traits of Pn, PE, Ci, Ti, Gs, Tr, WUE, Ls, φ, Amax, k and Rady of the cotton leaves. (4)Salt dust can significantly damage the physiological functions of the cotton leaves, resulting in a decrease in leaf chlorophyll and carotenoid content, and increasing cytoplasmic membrane permeability and malondialdehyde (MDA) content by increasing the soluble sugar and proline to adjust for the loss of the cell cytosol. This increases the activity of antioxidant enzymes to eliminate harmful materials, such as the intracellular reactive oxygen and MDA, thus reducing the damage caused by the salt dust and maintaining normal physiological functioning. Overall, this work found that the salt dust deposition was a problem for the crop and the salt dust could significantly influence the physiological and biochemical processes of the cotton leaves. This will eventually damage the leaves and reduce the cotton production, leading to agricultural economic loss. Therefore, attention should be paid to salt dust storms in the Ebinur Basin and efficient measures should be undertaken to protect the environment.

The Disastrous Effects of Salt Dust Deposition on Cotton Leaf Photosynthesis and the Cell Physiological Properties in the Ebinur Basin in Northwest China

PubMed Central

Abuduwaili, Jilili; Zhaoyong, Zhang; Feng qing, Jiang; Dong wei, Liu

2015-01-01

Salt dust in rump lake areas in arid regions has long been considered an extreme stressor for both native plants and crops. In recent years, research on the harmful effects of salt dust on native plants has been published by many scholars, but the effect on crops has been little studied. In this work, in order to determine the impact of salt dust storms on cotton, we simulated salt dust exposure of cotton leaves in Ebinur Basin in Northwest China, and measured the particle sizes and salt ions in the dust, and the photosynthesis, the structure and the cell physiological properties of the cotton leaves. (1) Analysis found that the salt ions and particle sizes in the salt dust used in the experiments were consistent with the natural salt dust and modeled the salt dust deposition on cotton leaves in this region. (2) The main salt cations on the surface and inside the cotton leaves were Na+, Ca2+, Cl- and SO4 2-, while the amounts of CO3 - and HCO3 - were low. From the analysis, we can order the quantity of the salt cations and anions ions present on the surface and inside the cotton leaves as Na+>Ca2+>Mg2+>K+ and Cl->SO4 2->HCO3 ->CO3 -, respectively. Furthermore, the five salt dust treatment groups in terms of the total salt ions on both the surface and inside the cotton leaves were A(500g.m-2)>B(400g.m-2)>C(300g.m-2)>D(200g.m-2)>E(100g.m-2)>F(0g.m-2). (3)The salt dust that landed on the surface of the cotton leaves can significantly influence the photosynthetic traits of Pn, PE, Ci, Ti, Gs, Tr, WUE, Ls, φ, Amax, k and Rady of the cotton leaves. (4)Salt dust can significantly damage the physiological functions of the cotton leaves, resulting in a decrease in leaf chlorophyll and carotenoid content, and increasing cytoplasmic membrane permeability and malondialdehyde (MDA) content by increasing the soluble sugar and proline to adjust for the loss of the cell cytosol. This increases the activity of antioxidant enzymes to eliminate harmful materials, such as the intracellular reactive oxygen and MDA, thus reducing the damage caused by the salt dust and maintaining normal physiological functioning. Overall, this work found that the salt dust deposition was a problem for the crop and the salt dust could significantly influence the physiological and biochemical processes of the cotton leaves. This will eventually damage the leaves and reduce the cotton production, leading to agricultural economic loss. Therefore, attention should be paid to salt dust storms in the Ebinur Basin and efficient measures should be undertaken to protect the environment. PMID:25970440

Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition

PubMed Central

Shimada, Tsutomu; Kim, Donghak; Murayama, Norie; Tanaka, Katsuhiro; Takenaka, Shigeo; Nagy, Leslie D.; Folkman, Lindsay M.; Foroozesh, Maryam K.; Komori, Masayuki; Yamazaki, Hiroshi; Guengerich, F. Peter

2014-01-01

A total of 68 chemicals including derivatives of naphthalene, phenanthrene, fluoranthene, pyrene, biphenyl, and flavone were examined for their abilities to interact with human P450s 2A13 and 2A6. Fifty-one of these 68 chemicals induced stronger Type I binding spectra (iron low- to high-spin state shift) with P450 2A13 than those seen with P450 2A6, i.e. the spectral binding intensities (ΔAmax/Ks ratio) determined with these chemicals were always higher for P450 2A13. In addition, benzo[c]phenanthrene, fluoranthene, 2,3-dihydroxy-2,3-dihydrofluoranthene, pyrene, 1-hydroxypyrene, 1-nitropyrene, 1-acetylpyrene, 2-acetylpyrene, 2,5,2’,5’-tetrachlorobiphenyl, 7-hydroxyflavone, chrysin, and galangin were found to induce a Type I spectral change only with P450 2A13. Coumarin 7-hydroxylation, catalyzed by P450 2A13, was strongly inhibited by 2’-methoxy-5,7-dihydroxyflavone, 2-ethynylnaphthalene, 2’-methoxyflavone, 2-naphththalene propargyl ether, acenaphthene, acenaphthylene, naphthalene, 1-acetylpyrene, flavanone, chrysin, 3-ethynylphenanthrene, flavone, and 7-hydroxyflavone; these chemicals induced Type I spectral changes with low Ks values. On the basis of the intensities of the spectral changes and inhibition of P450 2A13, we classified the 68 chemicals into eight groups based on the order of affinities for these chemicals and inhibition of P450 2A13. The metabolism of chemicals by P450 2A13 during the assays explained why some of the chemicals that bound well were poor inhibitors of P450 2A13. Finally, we compared the 68 chemicals for their abilities to induce Type I spectral changes of P450 2A13 with the Reverse Type I binding spectra observed with P450 1B1: 45 chemicals interacted with both P450s 2A13 and 1B1, indicating that the two enzymes have some similarty of structural features regarding these chemicals. Molecular docking analyses suggest similarities at the active sites of these P450 enzymes. These results indicate that P450 2A13, as well as Family 1 P450 enzymes, is able to catalyze many detoxication and activation reactions with chemicals of environmental interest. PMID:23432429

Pre-Activity Modulation of Lower Extremity Muscles Within Different Types and Heights of Deep Jump

PubMed Central

Mrdakovic, Vladimir; Ilic, Dusko B.; Jankovic, Nenad; Rajkovic, Zeljko; Stefanovic, Djordje

2008-01-01

The purpose of this study was to determine modulation of pre- activity related to different types and heights of deep jump. Sixteen male soccer players without experience in deep jumps training (the national competition; 15.0 ± 0.5yrs; weight 61.9 ± 6.1kg; height 1.77 ± 0.07m), who participated in the study, performed three types of deep jump (bounce landing, counter landing, and bounce drop jump) from three different heights (40cm, 60cm, and 80cm). Surface EMG device (1000Hz) was used to estimate muscle activity (maximal amplitude of EMG - AmaxEMG; integral EMG signal - iEMG) of five muscles (mm.gastrocnemii, m.soleus, m.tibialis anterior, m.vastus lateralis) within 150ms before touchdown. All the muscles, except m. gastrocnemius medialis, showed systematic increase in pre-activity when platform height was raised. For most of the lower extremity muscles, the most significant differences were between values of pre-activity obtained for 40 cm and 80 cm platforms. While the amount of muscle pre-activity in deep jumps from the heights above and beneath the optimal one did not differ significantly from that generated in deep jumps from the optimal drop height of 60 cm, the patterns of muscle pre-activity obtained for the heights above the optimal one did differ from those obtained for the optimal drop height. That suggests that deep jumps from the heights above the optimal one do not seem to be an adequate exercise for adjusting muscle activity for the impact. Muscle pre-activity in bounce drop jumps differed significantly from that in counter landing and bounce landing respectively, which should indicate that a higher amount of pre-activity generated during bounce drop jumps was used for performing take-offs. As this study included the subjects who were not familiar with deep jumps training, the prospective studies should reveal the results of athletes with previous experience. Key pointsHeight factor proved to be more relevant for the change in pre-activation level compared to the drop jump type factor.There is evident qualitative difference in pattern of pre-activation from lower and higher drop heights, compared to pattern of pre-activation obtained from optimal drop height.Drop jumps from the heights above the optimal one are not adequate for nicely preparing muscle activity for the impact. PMID:24149460

7 CFR 959.48 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 959.48 Section 959.48... Regulating Handling Research and Development § 959.48 Research and development. The committee, with the... research, and development projects designed to assist, improve, or promote the marketing, distribution...

7 CFR 956.50 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 956.50 Section 956.50... WALLA VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Research and Development § 956.50 Research and... establishment of production research, marketing research and development, and marketing promotion projects...

7 CFR 930.48 - Research, market development and promotion.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research, market development and promotion. 930.48... Order Regulating Handling Research, Market Development and Promotion § 930.48 Research, market... establishment of production and processing research, market research and development, and/or promotional...

7 CFR 947.47 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 947.47 Section 947.47... Research and Development § 947.47 Research and development. The committee, with the approval of the Secretary, may provide for the establishment of marketing research and development projects designed to...

7 CFR 947.47 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 947.47 Section 947.47... Research and Development § 947.47 Research and development. The committee, with the approval of the Secretary, may provide for the establishment of marketing research and development projects designed to...

7 CFR 981.41 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 981.41 Section 981.41... Regulating Handling Research § 981.41 Research and development. (a) General. The Board, with the approval of... research, marketing research and development projects, and marketing promotion including paid advertising...

7 CFR 927.47 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 927.47 Section 927.47... WASHINGTON Order Regulating Handling Research and Development § 927.47 Research and development. The Fresh... provide for the establishment of production and post-harvest research, or marketing research and...

48 CFR 31.205-48 - Research and development costs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Research and development... Organizations 31.205-48 Research and development costs. Research and development, as used in this subsection... grant for research and development effort, the excess is unallowable under any other Government contract...

48 CFR 31.205-48 - Research and development costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Research and development... Organizations 31.205-48 Research and development costs. Research and development, as used in this subsection... grant for research and development effort, the excess is unallowable under any other Government contract...

Alternative Fuels Data Center: Hydrogen Research and Development

Science.gov Websites

Research and Development to someone by E-mail Share Alternative Fuels Data Center: Hydrogen Research and Development on Facebook Tweet about Alternative Fuels Data Center: Hydrogen Research and Development on Twitter Bookmark Alternative Fuels Data Center: Hydrogen Research and Development on Google

Adaptive Optics Imaging of the Circumbinary Disk around the T Tauri Binary UY Aurigae: Estimates of the Binary Mass and Circumbinary Dust Grain Size Distribution

NASA Astrophysics Data System (ADS)

Close, L. M.; Dutrey, A.; Roddier, F.; Guilloteau, S.; Roddier, C.; Northcott, M.; Ménard, F.; Duvert, G.; Graves, J. E.; Potter, D.

1998-05-01

We have obtained high-resolution (FWHM = 0.15") deep images of the UY Aur binary at J, H, and K' with the University of Hawaii adaptive optics instrument. We clearly detect an R ~ 500 AU circumbinary disk discovered with millimeter interferometry, making UY Aur the second young binary with a confirmed circumbinary disk. It appears that the disk is inclined ~42° from face on. We find that the near side of the disk is brighter than the far side by factors of 2.6, 2.7, and 6.5 times at K', H, and J, respectively. The original GG Tau circumbinary disk has been reexamined and is found to have similar flux ratios of 1.5, 2.6, and 3.6 at K', H, and J, respectively. A realistic power-law distribution (p = 4.7) of spherical dust aggregates (composed of silicates, amorphous carbon, and graphite) that reproduces the observed ISM extinction curve also predicts these observed flux ratios from Mie scattering theory. We find the observed preference of forward-scattering over back-scattering is well fitted (global χ2 minimization) by Mie scattering off particles in the range amin = 0.03 μm to amax = 0.5-0.6 μm. The existence of a significant population of grain radii larger than 0.6 μm is not supported by the scattering observations. Based on the observed disk inclination we derive an orbit for UY Aur where the mass for the binary is 1.6+0.47-0.67 M⊙. Based on the observed K7 and M0 spectral types for UY Aur A and B, accretion disk models for the inner disks around the central stars were constructed. The models suggest that small (lower limit R ~ 5-10 AU) inner disks exist around B and A. It appears that B is accreting ~5 times faster than A, and that both inner disks may be exhausted in ~102-103 yr without replenishment from the outer circumbinary disk. Our images suggest that these inner disks may indeed be resupplied with material through thin streamers of material that penetrate inside the circumbinary disk. Currently it appears that such a streamer may be a close to UY Aur B. Comparison of our IR images and the millimeter images of the gas clearly show that the dust seen in our IR images traces the gas in the circumbinary disk, as was also the case with GG Tau.

Programs for developing the pipeline of early-career geriatric mental health researchers: outcomes and implications for other fields.

PubMed

Bartels, Stephen J; Lebowitz, Barry D; Reynolds, Charles F; Bruce, Martha L; Halpain, Maureen; Faison, Warachal E; Kirwin, Paul D

2010-01-01

This report summarizes the findings and recommendations of an expert consensus workgroup that addressed the endangered pipeline of geriatric mental health (GMH) researchers. The workgroup was convened at the Summit on Challenges in Recruitment, Retention, and Career Development in Geriatric Mental Health Research in late 2007. Major identified challenges included attracting and developing early-career investigators into the field of GMH research; a shortfall of geriatric clinical providers and researchers; a disproportionate lack of minority researchers; inadequate mentoring and career development resources; and the loss of promising researchers during the vulnerable period of transition from research training to independent research funding. The field of GMH research has been at the forefront of developing successful programs that address these issues while spanning the spectrum of research career development. These programs serve as a model for other fields and disciplines. Core elements of these multicomponent programs include summer internships to foster early interest in GMH research (Summer Training on Aging Research Topics-Mental Health Program), research sponsorships aimed at recruitment into the field of geriatric psychiatry (Stepping Stones), research training institutes for early career development (Summer Research Institute in Geriatric Psychiatry), mentored intensive programs on developing and obtaining a first research grant (Advanced Research Institute in Geriatric Psychiatry), targeted development of minority researchers (Institute for Research Minority Training on Mental Health and Aging), and a Web-based clearinghouse of mentoring seminars and resources (MedEdMentoring.org). This report discusses implications of and principles for disseminating these programs, including examples of replications in fields besides GMH research.

7 CFR 955.50 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 955.50 Section 955.50... Research and Development § 955.50 Research and development. (a) The committee, with the approval of the Secretary, may establish or provide for the establishment of production research, marketing research and...

Setting a research question, aim and objective.

PubMed

Doody, Owen; Bailey, Maria E

2016-03-01

To describe the development of a research question, aim and objective. The first steps of any study are developing the research question, aim and objective. Subsequent steps develop from these and they govern the researchers' choice of population, setting, data to be collected and time period for the study. Clear, succinctly posed research questions, aims and objectives are essential if studies are to be successful. Researchers developing their research questions, aims and objectives generally experience difficulties. They are often overwhelmed trying to convert what they see as a relevant issue from practice into research. This necessitates engaging with the relevant published literature and knowledgeable people. This paper identifies the issues to be considered when developing a research question, aim and objective. Understanding these considerations will enable researchers to effectively present their research question, aim and objective. To conduct successful studies, researchers should develop clear research questions, aims and objectives.

Establishment of research-oriented hospital: an important way for translational medicine development in China.

PubMed

Li, Meina; Zhang, Lulu

2015-01-01

Globally, one of the major trends is the development of translational medicine. The traditional hospital structure could not meet the demands of translational medicine development any longer and to explore a novel hospital structure is imperative. Following the times, China proposed and implemented a development strategy for a first-class modern research-oriented hospital. To establish a research-oriented hospital has become an important strategy to guide the scientific development of high-quality medical institutions and to advance translational medicine development. To facilitate translational medicine by developing research-oriented hospital, the Chinese Research Hospital Association (CRHA) has been established, which provides service of medicine, talents cultivation, scientific research and clinical teaching and covers areas of theoretical research, academic exchange, translational medicine, talents training and practice guiding. On the whole, research-oriented hospital facilitated translational medicine by developing interdisciplinary platform, training core competencies in clinical and translational research, providing financial support of translational research, and hosting journals on translational medicine, etc.

7 CFR 915.45 - Production research, marketing research and development.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Production research, marketing research and... AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Order Regulating Handling Research and Development § 915.45 Production research, marketing research and development. The committee may, with the approval of the...

7 CFR 915.45 - Production research, marketing research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Production research, marketing research and... AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Order Regulating Handling Research and Development § 915.45 Production research, marketing research and development. The committee may, with the approval of the...

7 CFR 915.45 - Production research, marketing research and development.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Production research, marketing research and... AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Order Regulating Handling Research and Development § 915.45 Production research, marketing research and development. The committee may, with the approval of the...

7 CFR 915.45 - Production research, marketing research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Production research, marketing research and... AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Order Regulating Handling Research and Development § 915.45 Production research, marketing research and development. The committee may, with the approval of the...

7 CFR 915.45 - Production research, marketing research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research, marketing research and... AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Order Regulating Handling Research and Development § 915.45 Production research, marketing research and development. The committee may, with the approval of the...

7 CFR 906.37 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 906.37 Section 906.37... LOWER RIO GRANDE VALLEY IN TEXAS Order Regulating Handling Research and Development § 906.37 Research... establishment of marketing research and development projects, including paid advertising, designed to assist...

7 CFR 948.35 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 948.35 Section 948.35... Order Regulating Handling Research and Development § 948.35 Research and development. The committee, with the approval of the Secretary, may provide for the establishment of marketing research and...

7 CFR 959.48 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 959.48 Section 959.48... Regulating Handling Research and Development § 959.48 Research and development. The committee, with the approval of the Secretary, may establish or provide for the establishment of production research, marketing...

Research and development of optical measurement techniques for aerospace propulsion research: A NASA Lewis Research Center perspective

NASA Technical Reports Server (NTRS)

Lesco, Daniel J.

1991-01-01

The applied research effort required to develop new nonintrusive measurement techniques capable of obtaining the data required by aerospace propulsion researchers and of operating in the harsh environments encountered in research and test facilities is discussed and illustrated through several ongoing projects at NASA's Lewis Research Center. Factors including length of development time, funding levels, and collaborative support from fluid-thermal researchers are cited. Progress in developing new instrumentation via a multi-path approach, including NASA research, grant, and government-sponsored research through mechanisms like the Small Business Innovative Research program, is also described.

Challenges of Research and Human Capital Development in Nigeria

ERIC Educational Resources Information Center

Chikwe, Christian K.; Ogidi, Reuben C.; Nwachukwu, K.

2015-01-01

The paper discussed the challenges of research and human capital development in Nigeria. Research and human capital development are critical to the development of any nation. Research facilitates human capital development. A high rating in human capital development indices places a country among the leading countries of the world. The paper…

7 CFR 948.35 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 948.35 Section 948.35... Order Regulating Handling Research and Development § 948.35 Research and development. The committee... development projects designed to assist, improve, or promote the marketing, distribution, and consumption of...

7 CFR 925.45 - Production research and market research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research and market research and... AGRICULTURE GRAPES GROWN IN A DESIGNATED AREA OF SOUTHEASTERN CALIFORNIA Research and Market Development § 925.45 Production research and market research and development. The committee, with the approval of the...

7 CFR 917.39 - Production research, market research and development.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Production research, market research and development... AGRICULTURE FRESH PEARS AND PEACHES GROWN IN CALIFORNIA Order Regulating Handling Research § 917.39 Production research, market research and development. The committees, with the approval of the Secretary, may...

7 CFR 925.45 - Production research and market research and development.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Production research and market research and... AGRICULTURE GRAPES GROWN IN A DESIGNATED AREA OF SOUTHEASTERN CALIFORNIA Research and Market Development § 925.45 Production research and market research and development. The committee, with the approval of the...

7 CFR 917.39 - Production research, market research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Production research, market research and development... AGRICULTURE FRESH PEARS AND PEACHES GROWN IN CALIFORNIA Order Regulating Handling Research § 917.39 Production research, market research and development. The committees, with the approval of the Secretary, may...

7 CFR 925.45 - Production research and market research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Production research and market research and... AGRICULTURE GRAPES GROWN IN A DESIGNATED AREA OF SOUTHEASTERN CALIFORNIA Research and Market Development § 925.45 Production research and market research and development. The committee, with the approval of the...

7 CFR 925.45 - Production research and market research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Production research and market research and... AGRICULTURE GRAPES GROWN IN A DESIGNATED AREA OF SOUTHEASTERN CALIFORNIA Research and Market Development § 925.45 Production research and market research and development. The committee, with the approval of the...

7 CFR 917.39 - Production research, market research and development.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Production research, market research and development... AGRICULTURE FRESH PEARS AND PEACHES GROWN IN CALIFORNIA Order Regulating Handling Research § 917.39 Production research, market research and development. The committees, with the approval of the Secretary, may...

7 CFR 925.45 - Production research and market research and development.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Production research and market research and... AGRICULTURE GRAPES GROWN IN A DESIGNATED AREA OF SOUTHEASTERN CALIFORNIA Research and Market Development § 925.45 Production research and market research and development. The committee, with the approval of the...

7 CFR 917.39 - Production research, market research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research, market research and development... AGRICULTURE FRESH PEARS AND PEACHES GROWN IN CALIFORNIA Order Regulating Handling Research § 917.39 Production research, market research and development. The committees, with the approval of the Secretary, may...

7 CFR 917.39 - Production research, market research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Production research, market research and development... AGRICULTURE FRESH PEARS AND PEACHES GROWN IN CALIFORNIA Order Regulating Handling Research § 917.39 Production research, market research and development. The committees, with the approval of the Secretary, may...

Development of Mathematics Learning Strategy Module, Based on Higher Order Thinking Skill (Hots) To Improve Mathematic Communication And Self Efficacy On Students Mathematics Department

NASA Astrophysics Data System (ADS)

Andriani, Ade; Dewi, Izwita; Halomoan, Budi

2018-03-01

In general, this research is conducted to improve the quality of lectures on mathematics learning strategy in Mathematics Department. The specific objective of this research is to develop learning instrument of mathematics learning strategy based on Higher Order Thinking Skill (HOTS) that can be used to improve mathematical communication and self efficacy of mathematics education students. The type of research is development research (Research & Development), where this research aims to develop a new product or improve the product that has been made. This development research refers to the four-D Model, which consists of four stages: defining, designing, developing, and disseminating. The instrument of this research is the validation sheet and the student response sheet of the instrument.

Towards Sustainable Research Capacity Development and Research Ownership for Academic Institutes in Developing Countries: The Malawian Research Support Centre Model

ERIC Educational Resources Information Center

Gomo, Exnevia; Kalilani, Linda; Mwapasa, Victor; Trigu, Chifundo; Phiri, Kamija; Schmidt, Joann; van Hensbroek, Michael Boele

2011-01-01

In lesser-developed African countries, the lack of institutionalised support for research, combined with limited career opportunities and poor remuneration, have contributed to weak research infrastructure and capacity, and a continuing brain drain to developed countries. Malawi's Research Support Centre (RSC) model is novel in that it provides a…

Peer Assisted Study Sessions for Research Trainees

ERIC Educational Resources Information Center

Cusick, Anne; Camer, Danielle; Stamenkovic, Alexander; Zaccagnini, Melissa

2015-01-01

Research training should facilitate effective researcher role development. While researcher roles require the performance of specialised knowledge and skill, they also require development of personal research identities within social contexts. Interaction with research peers can provide opportunities for reflective role development. Ad-hoc…

7 CFR 927.47 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 927.47 Section 927.47... WASHINGTON Order Regulating Handling Research and Development § 927.47 Research and development. The Fresh... development projects designed to assist, improve, or promote the marketing, distribution, and consumption of...

27 CFR 25.196 - Removals for research, development or testing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... beer removed for research, development, or testing in daily records under § 25.292 and on the Brewer's... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removals for research... Analysis, Research, Development Or Testing § 25.196 Removals for research, development or testing. (a) A...

27 CFR 25.196 - Removals for research, development or testing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... beer removed for research, development, or testing in daily records under § 25.292 and on the Brewer's... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Removals for research... Analysis, Research, Development Or Testing § 25.196 Removals for research, development or testing. (a) A...

The Association of Polar Early Career Scientists (APECS): A Model for the Professional Development of Scientists (Invited)

NASA Astrophysics Data System (ADS)

Baeseman, J. L.; Apecs Leadership Team

2010-12-01

Efforts like the International Polar Year 2007-2008 (IPY) have helped to increase research efforts as well as enhancing the integration of education and outreach into research projects and developing the next generation of researchers. One of the major legacies of the IPY was the creation of the Association of Polar Early Career Scientists (APECS), which was developed in 2006 by young researchers and focuses on helping each other develop the skills needed for successful careers in research by working with senior mentors. APECS is an international and interdisciplinary organization of over 2000 early career researchers and educators with interests in the Polar Regions and the wider cryosphere from 45 countries. APECS aims to stimulate interdisciplinary and international research collaborations, and develop effective future leaders in polar research, education and outreach. This is achieved by - Facilitating international and interdisciplinary networking opportunities to share ideas and experiences and to develop new research directions and collaborations, - Providing opportunities for professional career development for both academic and alternative research professions, and - Promoting education and outreach as an integral component of polar research and to stimulate future generations of polar researchers. Since its inception, APECS has strived to develop a strong network of partnerships with senior international organizations and scientific bodies to provide career development opportunities for young researchers. These partnerships have led to early-career representation on science planning bodies at an international level, the mandate of early career researchers serving as co-chairs at science conferences, the development of a mentorship program, field schools and techniques workshops, mentor panel discussions at conferences and increased funding for young researchers to attend conferences. APECS has also worked with an international teachers network to develop “Polar Science and Global Climate: An International Resource Guide for Teachers and Researchers” which includes tips and tricks for scientists in communicating their research effectively. Because of its international membership, APECS used the internet as an effective tool to develop skills through a career development webinar series, literature discussion forum, and a virtual poster session where researchers can continue to present their research long after a conference poster session ends. These programs not only serve as ways for young researchers to develop their research, they also serve to provide leadership training to the many individuals who plan these activities and creates a strong sense of community across disciplinary and national boarders. The tools APECS has developed can be used to train the next generation of researchers in any field. But perhaps what is more important are the lessons learned from nurturing the organization to create a strong community of early career and senior researchers helping and motivating each other to improve and stay connected to research careers. This presentation will demonstrate how a young researcher driven effort can become an important and crucial component of any field of research on both the national and international level.

7 CFR 929.45 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 929.45 Section 929.45... LONG ISLAND IN THE STATE OF NEW YORK Order Regulating Handling Research § 929.45 Research and... establishment of production research, marketing research, and market development projects, including paid...

32 CFR 555.6 - Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND DEVELOPMENT AND TESTS, WORK FOR OTHERS § 555.6 Authority. The following delegations of authority to perform research and development and tests apply. (a) Major Corps of Engineers Research and Development Laboratories. The major Corps of...

77 FR 29848 - Order of Succession for the Office of Policy Development and Research

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... Assistant Secretary for Policy Development and Research is not available to exercise the powers or perform... officials within the Office of Policy Development and Research are hereby designated to exercise the powers... Policy Development and Research AGENCY: Office of the Assistant Secretary for Policy Development and...

77 FR 64952 - Proposed Information Collection; Comment Request; State Government Research and Development (R&D...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... Government Research and Development (R&D) Survey AGENCY: U.S. Census Bureau. ACTION: Notice. SUMMARY: The... and Development Survey (SGRD) to measure research and development supported and performed by state... legislative mandate, the NSF sponsored surveys of research and development since 1953, including since 2006...

Critical Issues in Research Design in Action Research in an SME Development Context

ERIC Educational Resources Information Center

McGrath, Helen; O'Toole, Thomas

2012-01-01

Purpose: The main aim of this paper is to develop guidelines on the critical issues to consider in research design in an action research (AR) environment for SME network capability development. Design/methodology/approach: The issues in research design for AR studies are developed from the authors' experience in running learning sets but, in…

75 FR 55360 - Networking and Information Technology Research and Development (NITRD) Program: Draft NITRD 2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... NATIONAL SCIENCE FOUNDATION Networking and Information Technology Research and Development (NITRD... Information Technology Research and Development (NITRD). ACTION: Notice, request for public comment. FOR..., the National Coordination Office for Networking and Information Technology Research and Development...

77 FR 42298 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-18

... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy Biomass Research and Development...: Notice of Solicitation of Nominations for Appointment as a Member of the Biomass Research and Development... Biomass Research and Development Technical Advisory Committee (Technical Advisory Committee). DATES: The...

75 FR 74026 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-30

... DEPARTMENT OF ENERGY Biomass Research and Development Technical Advisory Committee AGENCY.... SUMMARY: This notice announces an open meeting of the Biomass Research and Development Technical Advisory... participation. This notice announces the meeting of the Biomass Research and Development Technical Advisory...

48 CFR 235.070-1 - Indemnification under research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research and development contracts. 235.070-1 Section 235.070-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.070-1 Indemnification under research and development contracts. (a...

Developing a research and development strategy for primary care.

PubMed Central

Harris, A

1993-01-01

General practice research has been a minority activity and underfunded in the past. The creation of the purchaser and provider split, the introduction of medical audit, and the new research and development strategy for the NHS provide an opportunity to focus research on the health needs of the population. FHSAs, with the regional health authority, should develop a local strategy for research and development and appoint a lead officer, who may be the medical adviser. When negotiating contracts FHSAs need to back up their arguments with research evidence. NHS development research should cover quality, distribution, accessibility, outcome, and effectiveness. FHSAs should play a part in disseminating knowledge in the interests of achieving an effective and high quality service. GPs should be encouraged to participate in research by relaxing the regulations of compulsory hours of patient service and by creating a practice development allowance. Images p191-a PMID:8443486

Strengthening research capacity through the medical education partnership initiative: the Mozambique experience

PubMed Central

2013-01-01

Background Since Mozambique’s independence, the major emphasis of its higher educational institutions has been on didactic education. Because of fiscal and human resource constraints, basic and applied research activities have been relatively modest in scope, and priorities have often been set primarily by external collaborators. These factors have compromised the scope and the relevance of locally conducted research and have limited the impact of Mozambique’s universities as major catalysts for national development. Case description We developed a multi-institutional partnership to undertake a comprehensive analysis of the research environment at Mozambique’s major public universities to identify factors that have served as barriers to the development of a robust research enterprise. Based on this analysis, we developed a multifaceted plan to reduce the impact of these barriers and to enhance research capacity within Mozambique. Interventions On the basis of our needs assessment, we have implemented a number of major initiatives within participating institutions to facilitate basic and applied research activities. These have included specialized training programmes, a reorganization of the research administration infrastructure, the development of multiple collaborative research projects that have emphasized local research priorities and a substantial investment in bioinformatics. We have established a research support centre that provides grant development and management services to Mozambique’s public universities and have developed an independent Institutional Review Board for the review of research involving human research subjects. Multiple research projects involving both communicable and non-communicable diseases have been developed and substantial external research support has been obtained to undertake these projects. A sizable investment in biomedical informatics has enhanced both connectivity and access to digital reference material. Active engagement with relevant entities within the Government of Mozambique has aligned institutional development with national priorities. Conclusions Although multiple challenges remain, over the past 3 years significant progress has been made towards establishing conditions within which a broad range of basic, translational and clinical and public health research can be undertaken. Ongoing development of this research enterprise will enhance capacity to address critical locally relevant research questions and will leverage resources to accelerate the development of Mozambique’s national universities. PMID:24304706

The West African Health Organization's experience in improving the health research environment in the ECOWAS region.

PubMed

Aidam, Jude; Sombié, Issiaka

2016-04-20

The West African Health Organization (WAHO) implemented a research development program in West Africa during 2009-2013 using the Knowledge for Better Health Research Capacity Development Framework, developed by Pang et al. (Bull World Health Organ 81(11):815-820, 2003), on strategies used to improve the research environment. The framework has the following components: stewardship, financing, sustainable resourcing and research utilization. This paper describes how WAHO implemented this research development program in the West African region to help improve the research environment and lessons learnt. This is a retrospective review of the regional research development program using a triangulation of activity reports, an independent evaluation and the authors' experiences with stakeholders. This program was designed to address gaps along the components of the framework and to improve partnership. The activities, results and challenges are summarised for each component of the framework. The independent evaluation was conducted using over 180 semi-structured interviews of key stakeholders in the West African region and activity reports. WAHO and major stakeholders validated these findings during a regional meeting. All 15 ECOWAS countries benefited from this regional research development program. WAHO provided technical and financial support to eight countries to develop their policies, priorities and plans for research development to improve their research governance. WAHO, along with other technical and financial partners, organised many capacity-strengthening trainings in health systems research methodology, resource mobilization, ethical oversight and on HRWeb, a research information management platform. WAHO helped launch a regional network of health research institutions to improve collaboration between regional participating institutions. Further, WAHO developed strategic research partnerships and mobilised additional funding to support the program. The program supported 24 health research projects. High staff turnover, weak institutional capacities and ineffective collaboration were some of the challenges encountered during program activity implementation. The regional collaborative approach to health research development using this framework was effective given the challenges in the West African region. The achievements particularly with improved research partnerships and funding helped strengthen local health research environments. This highlights WAHO's role and the common experiences in the West African region in improving health research.

7 CFR 993.37 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 993.37 Section 993.37... CALIFORNIA Order Regulating Handling Prune Marketing Committee § 993.37 Research and development. The... research and development projects designed to assist, improve, or promote the marketing, distribution, and...

7 CFR 929.45 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 929.45 Section 929.45... development. (a) The committee, with the approval of the Secretary, may establish or provide for the establishment of production research, marketing research, and market development projects, including paid...

40 CFR 270.65 - Research, development, and demonstration permits.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Research, development, and... Special Forms of Permits § 270.65 Research, development, and demonstration permits. (a) The Administrator may issue a research, development, and demonstration permit for any hazardous waste treatment facility...

40 CFR 270.65 - Research, development, and demonstration permits.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Research, development, and... Special Forms of Permits § 270.65 Research, development, and demonstration permits. (a) The Administrator may issue a research, development, and demonstration permit for any hazardous waste treatment facility...

78 FR 46331 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

... DEPARTMENT OF ENERGY Biomass Research and Development Technical Advisory Committee AGENCY: Energy... Energy is soliciting nominations for candidates to fill vacancies on the Biomass Research and Development... INFORMATION: The Biomass Research and Development Act of 2000 (Biomass Act) [Pub. L. 106-224] requires...

48 CFR 35.004 - Publicizing requirements and expanding research and development sources.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and expanding research and development sources. 35.004 Section 35.004 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.004 Publicizing requirements and expanding research and development sources. (a) In order to...

7 CFR 993.37 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CALIFORNIA Order Regulating Handling Prune Marketing Committee § 993.37 Research and development. The... research and development projects designed to assist, improve, or promote the marketing, distribution, and... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 993.37 Section 993.37...

76 FR 3743 - Science and Technology Reinvention Laboratory Personnel Management Demonstration Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

... Demonstration Project, Department of the Army, Army Research, Development and Engineering Command, Armament Research, Development and Engineering Center (ARDEC); Notice #0;#0;Federal Register / Vol. 76 , No. 13... the Army, Army Research, Development and Engineering Command, Armament Research, Development and...

77 FR 14462 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development.... Name: Research, Engineering & Development Advisory Committee. Time and Date: April 18, 2012--9:30 a.m...

75 FR 48411 - Research, Engineering and Development Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-10

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development.... 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development (R, E&D) Advisory Committee. Name: Research, Engineering & Development Advisory Committee. Time and Date: September...

76 FR 44648 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development.... Name: Research, Engineering & Development Advisory Committee. Time and Date: September 21, 2011--9 a.m...

78 FR 16357 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development... hereby given of a meeting of the FAA Research, Engineering and Development (R,E&D) Advisory Committee. Name: Research, Engineering & Development Advisory Committee. Time and Date: April 24--8:30 a.m. to 4...

48 CFR 335.071 - Special determinations and findings affecting research and development contracting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... findings affecting research and development contracting. 335.071 Section 335.071 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071 Special determinations and findings affecting research and development contracting. OPDIV...

Redefining Professional Development. Newsletter

ERIC Educational Resources Information Center

Center for Comprehensive School Reform and Improvement, 2006

2006-01-01

The research on effective professional development is consistent across many studies. Researchers Willis Hawley and Linda Valli (Westchester Institute for Human Services Research, n.d.), in their synthesis of the professional development literature, find that high-quality teacher development is as follows: (1) Informed by research on teaching and…

78 FR 51713 - Strategic Environmental Research and Development Program, Scientific Advisory Board; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... DEPARTMENT OF DEFENSE Office of the Secretary Strategic Environmental Research and Development... Environmental Research and Development Program, Scientific Advisory Board (SAB). This notice is published in... meeting is to review new start research and development projects requesting Strategic Environmental...

Harnessing collaboration to build nursing research capacity: a research team journey.

PubMed

Priest, Helena; Segrott, Jeremy; Green, Barbara; Rout, Amelia

2007-08-01

This paper discusses a qualitative evaluation study, designed to explore nursing lecturers' research capability development through their engagement as co-researchers in a larger case study project (referred to as the 'main project'). It explores the justification for supporting research capacity development using this collaborative approach, the process and experience of undertaking collaborative research, and the effectiveness of this model of collaboration in developing new researchers. The paper also makes connections between the process of undertaking the research (designed to offer opportunities for inexperienced researchers to be involved) and the main project findings (which explored the ways in which academic schools develop research capacity). We first set the main project in its wider context and map key issues relating to research capacity development and collaboration in the literature, before outlining how we involved neophyte and 'midiphyte' researchers. The evaluative study, which is the focus of this paper, discusses the experiences of the neophyte researchers, and explores the synergies between the main project's key findings and the process of undertaking it. We conclude with some principles for using collaboration to build research capacity, visualised through a conceptual model. While this project was located within two universities in the UK, the development of research skills amongst nurses is likely to have broad international relevance. NB1 References to 'nursing', 'nursing research', and 'nursing education' are taken throughout to apply equally to midwifery, midwifery research, and midwifery education. NB2 For the purpose of this project, neophyte researchers are defined as staff needing formal training in research and involvement in others' research, and 'midiphyte' researchers as those with some training but needing support to develop research ideas.

Employing Design and Development Research (DDR): Approaches in the Design and Development of Online Arabic Vocabulary Learning Games Prototype

ERIC Educational Resources Information Center

Sahrir, Muhammad Sabri; Alias, Nor Aziah; Ismail, Zawawi; Osman, Nurulhuda

2012-01-01

The design and development research, first proposed by Brown and Collins in the 1990s, is currently among the well-known methods in educational research to test theory and validate its practicality. The method is also known as developmental research, design research, design-based research, formative research and design-cased and possesses…

Strengthening research governance for sustainable research: experiences from three Zimbabwean universities.

PubMed

Mashaah, Thokozile; Hakim, James; Chidzonga, Midion; Kangwende, Rugare A; Naik, Yogeshkumar; Federspiel, Nancy; Fiorillo, Suzanne; Scott, Jim; Gomo, Exnevia

2014-08-01

A robust research system requires a robust governance framework. As part of the Medical Education Partnership Initiative, three Zimbabwean universities partnered with two U.S. universities in a project to strengthen research governance in the Zimbabwean universities. The project aimed at (1) developing research policies, (2) strengthening central research management offices, (3) developing a research administration curriculum, and (4) enhancing awareness about the role and relevance of research administration in other universities and research institutions in Zimbabwe. Through the efforts of the partners, a generic research policy was developed and successfully adapted by the institutions. A curriculum was drafted, and module development experts are helping to finalize the curriculum to meet university requirements for accreditation of training research administrators. The Association of Research Managers of Zimbabwe was established to promote information sharing and professionalize research administration. The consortium approach enabled rapid and smooth development and adoption of research policies in the institutions. It also helped researchers and managers accept research administration as an essential structure and function. The experiences and lessons learned are reported here to benefit other institutions and consortia.

Strengthening Research Governance for Sustainable Research: Experiences from Three Zimbabwean Universities

PubMed Central

Mashaah, Thokozile; Hakim, James; Chidzonga, Midion; Kangwende, Rugare A.; Naik, Yogeshkumar; Federspiel, Nancy; Fiorillo, Suzanne; Scott, Jim; Gomo, Exnevia

2014-01-01

A robust research system requires a robust governance framework. As part of the Medical Education Partnership Initiative, three Zimbabwean universities partnered with two US universities in a project to strengthen research governance in the Zimbabwean universities. The project aimed at (1) developing research policies; (2) strengthening central research management offices; (3) developing a research administration curriculum; and (4) enhancing awareness about the role and relevance of research administration in other universities and research institutions in Zimbabwe. Through the efforts of the partners, a generic research policy was developed and successfully adapted by the institutions. A curriculum was drafted, and module development experts are helping to finalize the curriculum to meet university requirements for accreditation of training research administrators. The Association of Research Managers of Zimbabwe was established to promote information sharing and professionalize research administration. The consortium approach enabled rapid and smooth development and adoption of research policies in the institutions. It also helped researchers and managers accept research administration as an essential structure and function. The experiences and lessons learned are reported here to benefit other institutions and consortia. PMID:25072583

Human Research Program Science Management: Overview of Research and Development Activities

NASA Technical Reports Server (NTRS)

Charles, John B.

2007-01-01

An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

Report of the Research Secretariat on Social Services and Community Development.

ERIC Educational Resources Information Center

National Council of La Raza, Washington, DC.

The Research Secretariat on Social Services and Community Development was one of the five Hispanic research task forces funded by the Ford Foundation to determine Hispanic research priorities. Its three major purposes were the following: (1) to develop an Hispanic research and policy agenda which recommends research activities and prioritizes…

MIT Lincoln Laboratory Annual Report 2010

DTIC Science & Technology

2010-01-01

Research and Development Center (FFRDC) and a DoD Research and Development Laboratory. The Laboratory conducts research and development pertinent to...year, the Laboratory restruc- tured three divisions to focus research and development in areas that are increasingly important to the nation...the Director 3 Collaborations with MIT campus continue to grow, leveraging the strengths of researchers at both the Laboratory and campus. The

Use of health information technology to advance evidence-based care: lessons from the VA QUERI program.

PubMed

Hynes, Denise M; Weddle, Timothy; Smith, Nina; Whittier, Erika; Atkins, David; Francis, Joseph

2010-01-01

As the Department of Veterans Affairs (VA) Health Services Research and Development Service's Quality Enhancement Research Initiative (QUERI) has progressed, health information technology (HIT) has occupied a crucial role in implementation research projects. We evaluated the role of HIT in VA QUERI implementation research, including HIT use and development, the contributions implementation research has made to HIT development, and HIT-related barriers and facilitators to implementation research. Key informants from nine disease-specific QUERI Centers. Documentation analysis of 86 implementation project abstracts followed up by semi-structured interviews with key informants from each of the nine QUERI centers. We used qualitative and descriptive analyses. We found: (1) HIT provided data and information to facilitate implementation research, (2) implementation research helped to further HIT development in a variety of uses including the development of clinical decision support systems (23 of 86 implementation research projects), and (3) common HIT barriers to implementation research existed but could be overcome by collaborations with clinical and administrative leadership. Our review of the implementation research progress in the VA revealed interdependency on an HIT infrastructure and research-based development. Collaboration with multiple stakeholders is a key factor in successful use and development of HIT in implementation research efforts and in advancing evidence-based practice.

Development of the Learning Health System Researcher Core Competencies.

PubMed

Forrest, Christopher B; Chesley, Francis D; Tregear, Michelle L; Mistry, Kamila B

2017-08-04

To develop core competencies for learning health system (LHS) researchers to guide the development of training programs. Data were obtained from literature review, expert interviews, a modified Delphi process, and consensus development meetings. The competencies were developed from August to December 2016 using qualitative methods. The literature review formed the basis for the initial draft of a competency domain framework. Key informant semi-structured interviews, a modified Delphi survey, and three expert panel (n = 19 members) consensus development meetings produced the final set of competencies. The iterative development process yielded seven competency domains: (1) systems science; (2) research questions and standards of scientific evidence; (3) research methods; (4) informatics; (5) ethics of research and implementation in health systems; (6) improvement and implementation science; and (7) engagement, leadership, and research management. A total of 33 core competencies were prioritized across these seven domains. The real-world milieu of LHS research, the embeddedness of the researcher within the health system, and engagement of stakeholders are distinguishing characteristics of this emerging field. The LHS researcher core competencies can be used to guide the development of learning objectives, evaluation methods, and curricula for training programs. © Health Research and Educational Trust.

Driving towards an improved research and development culture.

PubMed

McNicholl, Mary P; Coates, Vivien; Dunne, Kathleen

2008-04-01

This study examined the research and development culture and capacity within one NHS Trust in Northern Ireland. Strengths and challenges were identified and opportunities for further research and development expansion were sought. This is a two-stage project incorporating a baseline survey (n = 379) followed by consultation with key stakeholders across the Trust (n = 11). In the survey, over half of the respondents (n = 194) stated they had participated in a research project and a significant number (n = 313) read health care journals. Identification of barriers to research resulted in findings similar to other published work. Staff responded positively about using research in practice (n = 328) and that practice should be influenced by research (n = 312). Nurse Managers indicated support for research and development activity. The study provides a starting point from which to develop a positive research and development culture within this Trust. After establishing a baseline of research and development activity across a large acute Trust, the strengths and weaknesses of such activity were identified with a view to informing a strategy to develop this aspect of professional activity. A change in an organizational culture cannot be made without full support of both the clinicians and their managers.

[Diagnosis of the productive capacity of the IMSS regarding health technologies].

PubMed

Figueroa-Lara, Alejandro; López-Fernández, Fátima Itzel; López-Domínguez, Adriana; Fajardo-Dolci, German

To quantify the production capacity and performance in research and technological developments of the Mexican Social Security Institute (IMSS). We identified and analyzed information of the legislation, human and financial resources, and infrastructure addressed for research and technological development of IMSS. We analyzed whether the information on the legal framework contained key features to boost research and technological development. Information on the human, financial, and infrastructure resources were obtained from official sources. The research productivity was identified by a bibliometric analysis in 2014; productivity in technological developments was identified by intellectual products. The legal framework of the IMSS has several areas for improvement to boost research and technological development, especially the guidelines for technology transfer. The IMSS has 438 researchers, 39 research units, and a budget of US$ 37.4 million for research and technological development. The rate of articles published per 10 researchers was 4.8; while rate patients was 1.8. The IMSS has a great potential to translate research into technological developments, it is only necessary to make some changes to the legal framework.

7 CFR 984.46 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 984.46 Section 984.46... Regulating Handling Administrative Body § 984.46 Research and development. The Board, with the approval of... research and development projects, and marketing promotion, including paid advertising, designed to assist...

7 CFR 924.45 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 924.45 Section 924.45... and development. The committee, with the approval of the Secretary, may establish or provide for the establishment of production research, and marketing research and development projects designed to assist...

75 FR 14243 - Research, Engineering And Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering And Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. Time and Date: April 21, 2010--9 a.m. to 5 p.m...

77 FR 54648 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-05

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. TIME AND DATE: September 26, 2012--9 a.m. to 4 p.m...

Key Considerations in Organizing and Structuring University Research

ERIC Educational Resources Information Center

Nguyen, T. L. Huong; Meek, Vincent Lynn

2015-01-01

University research capacity building has now become an increasingly important task in both developed and less developed countries. In this capacity building endeavour, research late-developer universities in particular need to develop a sound research organizational structure. However, what elements are needed in organizing and structuring…

48 CFR 46.308 - Cost-reimbursement research and development contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... research and development contracts. 46.308 Section 46.308 Federal Acquisition Regulations System FEDERAL... research and development contracts. The contracting officer shall insert the clause at 52.246-8, Inspection of Research and Development—Cost-Reimbursement, in solicitations and contracts for research and...

7 CFR 905.54 - Marketing, research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Marketing, research and development. 905.54 Section... Marketing, research and development. The committee may, with the approval of the Secretary, establish, or provide for the establishment of, projects including production research, marketing research and...

75 FR 3542 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-21

... unwarranted invasion of personal privacy. Disclosure would also reveal research proposals and research... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... (Federal Advisory Committee Act) that the Rehabilitation Research and Development Service Scientific Merit...

48 CFR 46.308 - Cost-reimbursement research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research and development contracts. 46.308 Section 46.308 Federal Acquisition Regulations System FEDERAL... research and development contracts. The contracting officer shall insert the clause at 52.246-8, Inspection of Research and Development—Cost-Reimbursement, in solicitations and contracts for research and...

A new approach to health research in Canada's North.

PubMed

Chatwood, Susan; Young, Kue

2010-01-01

Over the past four years, despite low resource allocations to the North, northern residents and community organizations have taken significant initiatives towards the development of health research. In this commentary, we present a model for the development of northern health research based on our experiences in establishing the Institute for Circumpolar Health Research (ICHR) in the Northwest Territories. It is hoped that the lessons we have learned will inform decision-makers and encourage them to make strategic investments to support further health research capacity and institutional development within the North. Factors that have enabled the development of a health research institute in the North include leadership, a vision for health research, and the engagement of key partners and stakeholders. Challenges arise in the development of appropriate governance and policy for health research. There is an urgency to target resources to support the development of policies and governance for health research in northern jurisdictions. Both academic and community-based research need to be strengthened.

The Case for Research in Pure Physics in Developing Countries

NASA Astrophysics Data System (ADS)

Mweene, H. V.

Science and technology are the keys to modern economic development. But, it has often been argued that poor countries cannot really afford to support research, or that they should at most devote their efforts to applied science only. The scientific knowledge necessary for development would then be partly or wholly obtained from other countries. In this paper, the case will be argued that developing countries cannot afford to leave research, both pure and applied, to the developed countries and that the only way the developing world is going to solve its problems is through development driven by their own research activities. With reference to physics, the importance of research by researchers in poor countries is explained. Lastly, it is outlined how the logistics of doing research under the difficult conditions prevailing in poor countries can be managed.

Defining Health Research for Development: The perspective of stakeholders from an international health research partnership in Ghana and Tanzania.

PubMed

Ward, Claire Leonie; Shaw, David; Anane-Sarpong, Evelyn; Sankoh, Osman; Tanner, Marcel; Elger, Bernice

2017-05-03

The study uses a qualitative empirical method to define Health Research for Development. This project explores the perspectives of stakeholders in an international health research partnership operating in Ghana and Tanzania. We conducted 52 key informant interviews with major stakeholders in an international multicenter partnership between GlaxoSmithKline (GSK, Vaccine Developer) and the global health nonprofit organisation PATH and its Malaria Vaccine Initiative program (PATH/MVI, Funder-Development Partner), (RTS, S) (NCT00866619). The respondents included teams from four clinical research centres (two centres in Ghana and two in Tanzania) and various collaborating partners. This paper analyses responses to the question: What is Health Research for Development? Based on the stakeholders' experience the respondents offered many ways of defining Health Research for Development. The responses fell into four broad themes: i) Equitable Partnerships; ii) System Sustainability; iii) Addressing Local Health Targets, and iv) Regional Commitment to Benefit Sharing. Through defining Health Research for Development six key learning points were generated from the four result themes: 1) Ensure there is local research leadership working with the collaborative partnership, and local healthcare system, to align the project agenda and activities with local research and health priorities; 2) Know the country-specific context - map the social, health, legislative and political setting; 3) Define an explicit development component and plan of action in a research project; 4) Address the barriers and opportunities to sustain system capacity. 5) Support decentralised health system decision-making to facilitate the translation pathway; 6) Govern, monitor and evaluate the development components of health research partnerships. Overall, equity and unity between partners are required to deliver health research for development. © 2017 John Wiley & Sons Ltd.

7 CFR 906.37 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 906.37 Section 906.37... LOWER RIO GRANDE VALLEY IN TEXAS Order Regulating Handling Research and Development § 906.37 Research and development. The committee, with the approval of the Secretary, may establish or provide for the...

7 CFR 958.47 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development. 958.47 Section 958.47... DESIGNATED COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Research and Development § 958.47 Research and development. (a) The committee with the approval of the Secretary, may establish...

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

7 CFR 958.47 - Research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development. 958.47 Section 958.47... DESIGNATED COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Research and Development § 958.47 Research and development. (a) The committee with the approval of the Secretary, may establish...

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

78 FR 18680 - Rehabilitation Research and Development Scientific Merit Review Board, Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Scientific Merit Review... Service, and the Chief Research and Development Officer on the scientific and technical merit, the mission... Committee Act, 5 U.S.C. App. 2, that a meeting of the Rehabilitation Research and Development Service...

ILLINOIS VOCATIONAL EDUCATION OCCUPATIONAL RESEARCH AND DEVELOPMENT COORDINATING UNIT FINAL REPORT.

ERIC Educational Resources Information Center

BURGENER, V.E.

AN OCCUPATIONAL RESEARCH AND DEVELOPMENT UNIT WAS CREATED TO PROVIDE ASSISTANCE IN A STATEWIDE PROGRAM OF VOCATIONAL RESEARCH TO DEVELOP RESEARCH PERSONNEL, TO EVALUATE EXPERIMENTAL CURRICULUM AND INSTRUCTIONAL PROCEDURES, TO DEVELOP AN OVERVIEW OF SURVEY PROCEDURES RELATED TO OCCUPATIONAL OPPORTUNITIES AND TRAINING NEEDS, TO REFINE THE OPERATING…

48 CFR 52.249-9 - Default (Fixed-Price Research and Development).

Code of Federal Regulations, 2011 CFR

2011-10-01

... Research and Development). 52.249-9 Section 52.249-9 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.249-9 Default (Fixed-Price Research and Development). As prescribed in 49.504(b), insert the following clause: Default (Fixed-Price Research and Development) (APR 1984) (a)(1) The...

48 CFR 52.249-9 - Default (Fixed-Price Research and Development).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Research and Development). 52.249-9 Section 52.249-9 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.249-9 Default (Fixed-Price Research and Development). As prescribed in 49.504(b), insert the following clause: Default (Fixed-Price Research and Development) (APR 1984) (a)(1) The...

48 CFR 52.249-9 - Default (Fixed-Price Research and Development).

Code of Federal Regulations, 2012 CFR

2012-10-01

... Research and Development). 52.249-9 Section 52.249-9 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.249-9 Default (Fixed-Price Research and Development). As prescribed in 49.504(b), insert the following clause: Default (Fixed-Price Research and Development) (APR 1984) (a)(1) The...

48 CFR 52.249-9 - Default (Fixed-Price Research and Development).

Code of Federal Regulations, 2013 CFR

2013-10-01

... Research and Development). 52.249-9 Section 52.249-9 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.249-9 Default (Fixed-Price Research and Development). As prescribed in 49.504(b), insert the following clause: Default (Fixed-Price Research and Development) (APR 1984) (a)(1) The...

48 CFR 52.249-9 - Default (Fixed-Price Research and Development).

Code of Federal Regulations, 2014 CFR

2014-10-01

... Research and Development). 52.249-9 Section 52.249-9 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.249-9 Default (Fixed-Price Research and Development). As prescribed in 49.504(b), insert the following clause: Default (Fixed-Price Research and Development) (APR 1984) (a)(1) The...

76 FR 12404 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. Time and Date: April 20, 2011--9:30 a.m. to 4 p.m...

Evaluation in a Research and Development Context.

ERIC Educational Resources Information Center

Cooley, William W.

Educational research and development (R&D) has often been characterized as a neat, linear sequence of discrete steps, moving from research through development to evaluation and dissemination. Although the inadequacies of such linear models of educational research and development have been pointed out previously, these models have been so much…

78 FR 70102 - Clinical Science Research and Development Service Cooperative Studies; Scientific Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative... notice under the Federal Advisory Committee Act, 5 U.S.C. App. 2, that the Clinical Science Research and... Development Officer through the Director of the Clinical Science Research and Development Service on the...

17 CFR 256.188 - Research, development, or demonstration expenditures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Research, development, or... COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 4. Deferred Debits § 256.188 Research, development, or... of all expenditures for research, development or demonstration undertaken by or sponsored through the...

7 CFR 930.48 - Research, market development and promotion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Research, market development and promotion. 930.48... Order Regulating Handling Research, Market Development and Promotion § 930.48 Research, market development and promotion. The Board, with the approval of the Secretary, may establish or provide for the...

Fetal Research

NASA Astrophysics Data System (ADS)

Hansen, John T.; Sladek, John R.

1989-11-01

This article reviews some of the significant contributions of fetal research and fetal tissue research over the past 20 years. The benefits of fetal research include the development of vaccines, advances in prenatal diagnosis, detection of malformations, assessment of safe and effective medications, and the development of in utero surgical therapies. Fetal tissue research benefits vaccine development, assessment of risk factors and toxicity levels in drug production, development of cell lines, and provides a source of fetal cells for ongoing transplantation trials. Together, fetal research and fetal tissue research offer tremendous potential for the treatment of the fetus, neonate, and adult.

Liver Biopsy

MedlinePlus

... Funding Current Funding Opportunities Research Programs & Contacts Human Subjects Research Funding Process Research Training & Career Development Funded ... Funding Current Funding Opportunities Research Programs & Contacts Human Subjects Research Funding Process Research Training & Career Development Funded ...

Action Research and Collaborative Research: Their Specific Contributions to Professional Development

ERIC Educational Resources Information Center

Savoie-Zajc, Lorraine; Descamps-Bednarz, Nadine

2007-01-01

The increasing complexity of the teaching profession calls for engaged professionals in their professional development. This article claims that participative types of research contribute differently to professional development. Its intent is to explore the different contributions action research and collaborative research bring. One action…

On Adaptive Extended Compatibility Changing Type of Product Design Strategy

NASA Astrophysics Data System (ADS)

Wenwen, Jiang; Zhibin, Xie

The article uses research ways of Enterprise localization and enterprise's development course to research strategy of company's product design and development. It announces at different stages for development, different kinds of enterprises will adopt product design and development policies of different modes. It also announces close causality between development course of company and central technology and product. The result indicated enterprises in leading position in market, technology and brand adopt pioneer strategy type of product research and development. These enterprise relying on the large-scale leading enterprise offering a complete set service adopts the passively duplicating type tactic of product research and development. Some enterprise in part of advantage in technology, market, management or brand adopt following up strategy of product research and development. The enterprises with relative advantage position adopt the strategy of technology applied taking optimizing services as centre in product research and development in fields of brand culture and market service.

Developing Education Research Competencies in Mathematics Teachers through TRAIL: Teacher-Researcher Alliance for Investigating Learning

ERIC Educational Resources Information Center

Koichu, Boris; Pinto, Alon

2018-01-01

This theoretical article explores an issue of developing education research competencies in mathematics teachers through their involvement in mathematics education research. We first argue that the development of education research competencies is beneficial for the teachers' professional growth. We then identify opportunities for mathematics…

The Challenges of Developing Research Resources for Leading Vietnamese Universities

ERIC Educational Resources Information Center

Nguyen, Thi Lan Huong

2013-01-01

This paper examines the challenges of developing research resources for leading Vietnamese universities. The first part of the paper presents the background to the study, including literature review on the challenges to research resources development, and describes the research questions and research methods. The next part provides empirical…

75 FR 40036 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-13

.... Disclosure would also reveal research proposals and research underway which could lead to the loss of these... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... (Federal Advisory Committee Act) that the Rehabilitation Research and Development Service Scientific Merit...

48 CFR 3035.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Scope of Part 3035.017 Federally Funded Research and... use of Federally Funded Research and Development Centers (FFRDCs) in (FAR) 48 CFR 35.017. [71 FR 25771... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Federally Funded Research...

48 CFR 1335.017 - Federal funded research and development centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.017 Federal funded research and development centers. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Federal funded research...

Basic science research and education: a priority for training and capacity building in developing countries.

PubMed

Deckelbaum, Richard J; Ntambi, James M; Wolgemuth, Debra J

2011-09-01

This article provides evidence that basic science research and education should be key priorities for global health training, capacity building, and practice. Currently, there are tremendous gaps between strong science education and research in developed countries (the North) as compared to developing countries (the South). In addition, science research and education appear as low priorities in many developing countries. The need to stress basic science research beyond the typical investment of infectious disease basic service and research laboratories in developing areas is significant in terms of the benefits, not only to education, but also for economic strengthening and development of human resources. There are some indications that appreciation of basic science research education and training is increasing, but this still needs to be applied more rigorously and strengthened systematically in developing countries. Copyright © 2011 Elsevier Inc. All rights reserved.

Providing ethical guidance for collaborative research in developing countries

PubMed Central

Morris, Nina

2015-01-01

Experience has shown that the application of ethical guidelines developed for research in developed countries to research in developing countries can be, and often is, impractical and raises a number of contentious issues. Various attempts have been made to provide guidelines more appropriate to the developing world context; however, to date these efforts have been dominated by the fields of bioscience, medical research and nutrition. There is very little advice available for those seeking to undertake collaborative social science or natural science research in developing countries and what is there tends to be held within disparate sources. Charting the development of a set of ethics documentation for future use by the Ecosystem Services for Poverty Alleviation (ESPA) programme research community, this paper outlines past and present attitudes towards ethics procedures amongst this community and suggests ways in which ethics procedures might be made more relevant and user-friendly to researchers working in this area. PMID:26640509

24. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, Natick, Mass, Climatic Building, First Floor Plan, Architectural. Drawing No. 35-07-01, Sheet 2 of 72, 1952, updated to 1985. (Source: NRDEC). - Natick Research & Development Laboratories, Climatic Chambers Building, U.S. Army Natick Research, Development & Engineering Center (NRDEC), Natick, Middlesex County, MA

76 FR 6197 - Health Services Research and Development Service Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... Patient Response to Care; HSR 3-Informatics and Research Methods Development; HSR 4-Mental and Behavioral... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Merit Review Board... Advisory Committee Act) that a meeting of the Health Services Research and Development Service Merit Review...

76 FR 53938 - Order of Succession for the Office of Policy Development and Research

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

... Office of Policy Development and Research AGENCY: Office of the Assistant Secretary for Policy Development and Research, HUD. ACTION: Notice of order of succession. SUMMARY: In this notice, the Assistant Secretary for Policy Development and Research designates the Order of Succession for the Office of the...

7 CFR 400.712 - Research and development reimbursement, maintenance reimbursement, and user fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Research and development reimbursement, maintenance... Submission of Policies, Provisions of Policies and Rates of Premium § 400.712 Research and development... submission may be eligible for a one-time payment of research and development costs and reimbursement of...

Academic and Educational Development: Research, Evaluation and Changing Practice in Higher Education. Staff and Educational Development Series.

ERIC Educational Resources Information Center

Macdonald, Ranald; Wisdom, James

This practice-oriented book brings together research and evaluation approaches and supporting case studies from educational researchers and teachers. The emphasis is on changing practice in higher education and the research that underpins desirable development. Following an introduction, chapter 1 presents Educational Development Changing Practice…

25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, Natick, Mass. Climatic Building, First Floor Plan, Refrigeration and Engineering. Drawing No. 35-07-01, Sheet 52 of 72, 1952. (Source: NRDEC). - Natick Research & Development Laboratories, Climatic Chambers Building, U.S. Army Natick Research, Development & Engineering Center (NRDEC), Natick, Middlesex County, MA

48 CFR 31.205-48 - Research and development costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Research and development... Organizations 31.205-48 Research and development costs. Research and development, as used in this subsection, means the type of technical effort described in 31.205-18 but sponsored by a grant or required in the...

A Needs Assessment Informs Development of a Participatory Research Faculty Development Workshop

ERIC Educational Resources Information Center

Salsberg, Jon; Seller, Robbyn; Shea, Laura; Macaulay, Ann C.

2012-01-01

University-based researchers are finding they need a new set of skills to collaborate meaningfully with non-academic research partners, and to compete for funding opportunities that require community and end-user partnerships. This article describes a needs assessment conducted to develop a participatory research faculty development workshop at…

77 FR 31368 - Guidance on Meetings With Industry and Investigators on the Research and Development of Tobacco...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... the Research and Development of Tobacco Products'' to the Center for Tobacco Products, Food and Drug...] Guidance on Meetings With Industry and Investigators on the Research and Development of Tobacco Products... and Investigators on the Research and Development of Tobacco Products.'' This guidance describes FDA's...

Ethics in international health research: a perspective from the developing world.

PubMed Central

Bhutta, Zulfiqar Ahmed

2002-01-01

Health research plays a pivotal role in addressing inequities in health and human development, but to achieve these objectives the research must be based on sound scientific and ethical principles. Although it is accepted that ethics play a central role in health research in developing countries, much of the recent debate has focused on controversies surrounding internationally sponsored research and has taken place largely without adequate participation of the developing countries. The relationship between ethical guidelines and regulations, and indigenously sponsored and public health research has not been adequately explored. For example, while the fundamental principles of ethical health research, such as community participation, informed consent, and shared benefits and burdens, remain sacrosanct other issues, such as standards of care and prior agreements, merit greater public debate within developing countries. In particular, the relationship of existing ethical guidelines to epidemiological and public health research merits further exploration. In order to support health research in developing countries that is both relevant and meaningful, the focus must be on developing health research that promotes equity and on developing local capacity in bioethics. Only through such proactive measures can we address the emerging ethical dilemmas and challenges that globalization and the genomics revolution will bring in their wake. PMID:11953789

Integration of Staff Development and Research: Description of the Staff Development Project in Progress for the School Year 1975-1976. Technical Report #62.

ERIC Educational Resources Information Center

Speidel, Gisela E.

This report from the Kamehameha Early Education Program (KEEP) describes the 1975-76 KEEP staff development program, which was designed to integrate staff development and research. Specific purposes of the program were: (1) to develop the abilities of the teaching staff in teaching, consultation, and research; (2) to conduct pilot research in…

Research and Development Strategies in the Semiconductor Industry

NASA Astrophysics Data System (ADS)

Bowling, Allen

2003-03-01

In the 21st Century semiconductor industry, there is a critical balance between internally funded semiconductor research and development (R) and externally funded R. External R may include jointly-funded research collaborations/partnerships with other device manufacturers, jointly-funded consortia-based R, and individually-funded research programs at universities and other contract research locations. Each of these approaches has merits and each has costs. There is a critical balance between keeping the internal research and development pipeline filled and keeping it from being overspent. To meet both competitive schedule and cost goals, a semiconductor device manufacturer must decide on a model for selection of internal versus external R. Today, one of the most critical decisions is whether or not to do semiconductor research and development on 300 mm silicon wafers. Equipment suppliers are doing first development on 300 mm equipment. So, for the device manufacturer, there is a balance between the cost of doing development on 300 mm wafers and the development time schedule driven by equipment availability. In the face of these cost and schedule elements, device manufacturers are looking to consortia such as SEMATECH, SRC, and SRC MARCO for early development and screening of new materials and device structure approaches. This also causes much more close development collaboration between device manufacturer and equipment supplier. Many device manufacturers are also making use of direct contract research with universities and other contract-research organizations, such as IMEC, LETI, and other government-funded research organizations around the world. To get the most out of these external research interactions, the company must develop a strategy for management and technology integration of external R.

Research-tool patents: issues for health in the developing world.

PubMed Central

Barton, John H.

2002-01-01

The patent system is now reaching into the tools of medical research, including gene sequences themselves. Many of the new patents can potentially preempt large areas of medical research and lay down legal barriers to the development of a broad category of products. Researchers must therefore consider redesigning their research to avoid use of patented techniques, or expending the effort to obtain licences from those who hold the patents. Even if total licence fees can be kept low, there are enormous negotiation costs, and one "hold-out" may be enough to lead to project cancellation. This is making it more difficult to conduct research within the developed world, and poses important questions for the future of medical research for the benefit of the developing world. Probably the most important implication for health in the developing world is the possible general slowing down and complication of medical research. To the extent that these patents do slow down research, they weaken the contribution of the global research community to the creation and application of medical technology for the benefit of developing nations. The patents may also complicate the granting of concessional prices to developing nations - for pharmaceutical firms that seek to offer a concessional price may have to negotiate arrangements with research-tool firms, which may lose royalties as a result. Three kinds of response are plausible. One is to develop a broad or global licence to permit the patented technologies to be used for important applications in the developing world. The second is to change technical patent law doctrines. Such changes could be implemented in developed and developing nations and could be quite helpful while remaining consistent with TRIPS. The third is to negotiate specific licence arrangements, under which specific research tools are used on an agreed basis for specific applications. These negotiations are difficult and expensive, requiring both scientific and legal skills. But they will be an unavoidable part of international medical research. PMID:11953790

Funding of pilot projects in Latin America: a tool for capacity building in occupational health research.

PubMed

Felknor, Sarah A; Delclos, George L; Gimeno, David; Wesseling, Ineke; Monge, Patricia; Chavez, Jorge; Quintana, Leonardo; Schulze, Lawrence J H

2006-01-01

There is a global need for trained researchers who can address the increasing burden of illness and injury and prepare future generations of researchers. Developing countries have a special need for practical, action-oriented interventions to address workplace problems, based on identification of needs and priorities, development of locally available solutions, and consideration of the sociopolitical context of work and how best to translate research findings into policies. Effective translation and application of research products from industrialized nations to developing countries is essential, but differences in the contexts and local realities of other nations limit extrapolating such research. Funding pilot research projects in developing countries is an effective, practical, and useful tool for training new investigators in research techniques and developing collaborative relationships among countries.

Building research capital to facilitate research.

PubMed

Green, Gill; Rein, Melanie

2013-04-04

The National Institute for Health Research, Research Design Service (NIHR RDS) was set up to increase the number and proportion of high quality applications for funding for applied and patient focused health and social care research. Access to specialist expertise and collaboration between researchers and health practitioners at the proposal development stage is crucial for high quality applied health research. In this essay we develop the concept of 'research capital' to describe the wide range of resources and expertise required to develop fundable research projects. It highlights the key role the RDS plays supporting researchers to broker relationships to access the requisite 'research capital'.

Life Cycle Impact Assessment Research Developments and Needs

EPA Science Inventory

Life Cycle Impact Assessment (LCIA) developments are explained along with key publications which record discussions which comprised ISO 14042 and SETAC document development, UNEP SETAC Life Cycle Initiative research, and research from public and private research institutions. It ...

Instructional Developer as Content Specialist: Three Case Studies Utilizing the Instructional Development-Operations Research Model.

ERIC Educational Resources Information Center

Faust, Stephen M.

1980-01-01

Presents a 3-phase model (content research, specification, delivery) for instructional development-operations research and describes its application in developing courses in zoology, geology, and paleontology. (MER)

Institutional research and development, FY 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Struble, G.L.; Lawler, G.M.; Crawford, R.B.

The Institutional Research and Development program at Lawrence Livermore National Laboratory fosters exploratory work to advance science and technology, disciplinary research to develop innovative solutions to problems in various scientific fields, and long-term interdisciplinary research in support of defense and energy missions. This annual report describes research funded under this program for FY87. (DWL)

Intentionality and Developing Researcher Competence on a UK Master's Course: An Ecological Perspective on Research Education

ERIC Educational Resources Information Center

Stelma, Juup; Fay, Richard

2014-01-01

This paper presents an ecological perspective on the developing researcher competence of participants in the research education component of a professionally oriented master's course. There is a particular focus on the intentionality (as in "purpose") of the participants' research education activity. The data used to develop the…

Research on Child and Adolescent Development and Public Policy in Latin America

ERIC Educational Resources Information Center

Narea, Marigen

2016-01-01

This commentary discusses the implication of child and adolescent development research for public policy in Latin America. As illustrated by the articles in this special issue, even though the research of child and adolescent development in Latin America is making significant progress, still more research is needed. Developmental research in the…

Research Fellowships Program of the National Center for Health Services Research and Development. Policies and Guidelines for Applicants.

ERIC Educational Resources Information Center

Health Services and Mental Health Administration (DHEW), Bethesda, MD.

The National Center for Health Services Research and Development supports individual research training in an institutional setting for the development of competence in research techniques relevant to the organization, delivery, quality, financing, utilization, and evaluation of health delivery systems. The evolution of health services science…

Professional development workshops for physics education research

NASA Astrophysics Data System (ADS)

Sayre, Eleanor C.; Franklin, Scott V.; Kustusch, Mary Bridget

2017-01-01

Physics education research holds the promise of satisfying expectations of both scholarship, which is increasing at teaching-centric institutions, and teaching effectiveness, a concern at all institutions. Additionally, junior physics education researchers seek more diverse training in research methods and theories. Emerging education researchers need support as they develop their research programs and expand their theoretical and methodological expertise, and they benefit from the guidance of knowledgable peers and near-peers. Our two-part professional development model combines intensive in-person workshops with long-term remote activities. During a two-week in-person workshop, emerging and established education researchers work closely together to develop research questions, learn appropriate analytic techniques, and collect a corpus of data appropriate to their research questions. Afterwards, they meet biweekly in a distributed, mentored research group to share analyses and develop their ideas into publishable papers. In this talk, we discuss this model for professional development and show results from one three-year implementation in the IMPRESS program at the Rochester Institute of Technology. Partially funded by the PERTG of the AAPT.

The International Development Research Centre: A Guide for the Canadian University Research Community = Le Centre de recherches pour le developpement international: guide a l'intention des scientifiques des universites Canadiennes.

ERIC Educational Resources Information Center

Tillman, George; Wasilewski, Ania, Ed.

Written in both English and French this is a manual for the Canadian research community. It describes the International Development Research Centre (IDRC) and its operations. The main objective of the IDRC is to assist scientists in developing countries to identify and conduct research into long term practical solutions to development problems.…

Developing the Developers: Supporting and Researching the Learning of Professional Development Facilitators

ERIC Educational Resources Information Center

Perry, Emily; Boylan, Mark

2018-01-01

Research on teacher professional development is extensive but there are fewer studies about the practitioners who facilitate professional development. Here we report on a pilot programme for professional development facilitators rooted in a cycle of action research. Informed by a categorisation of professional knowledge and skills of facilitators,…

7 CFR 929.45 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... establishment of production research, marketing research, and market development projects, including paid... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 929.45 Section 929.45 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

76 FR 36102 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy Biomass Research and Development... vacancies on the Biomass Research and Development Technical Advisory Committee (Technical Advisory Committee... 20585; (202) 586-7766; E-mail: [email protected] . SUPPLEMENTARY INFORMATION: The Biomass Research...

Effectiveness of Training Model Capacity Building for Entrepreneurship Women Based Empowerment Community

ERIC Educational Resources Information Center

Idawati; Mahmud, Alimuddin; Dirawan, Gufran Darma

2016-01-01

The purpose of this research was to determine the effectiveness of a training model for capacity building of women entrepreneurship community-based. Research type approach Research and Development Model, which refers to the model of development research that developed by Romiszowki (1996) combined with a model of development Sugiono (2011) it was…

40 CFR 80.380 - What are the requirements for obtaining an exemption for gasoline used for research, development...

Code of Federal Regulations, 2014 CFR

2014-07-01

... obtaining an exemption for gasoline used for research, development or testing purposes? 80.380 Section 80... obtaining an exemption for gasoline used for research, development or testing purposes? Any person may request an exemption from the provisions of this subpart for gasoline used for research, development or...

40 CFR 80.380 - What are the requirements for obtaining an exemption for gasoline used for research, development...

Code of Federal Regulations, 2013 CFR

2013-07-01

... obtaining an exemption for gasoline used for research, development or testing purposes? 80.380 Section 80... obtaining an exemption for gasoline used for research, development or testing purposes? Any person may request an exemption from the provisions of this subpart for gasoline used for research, development or...

40 CFR 80.380 - What are the requirements for obtaining an exemption for gasoline used for research, development...

Code of Federal Regulations, 2012 CFR

2012-07-01

... obtaining an exemption for gasoline used for research, development or testing purposes? 80.380 Section 80... obtaining an exemption for gasoline used for research, development or testing purposes? Any person may request an exemption from the provisions of this subpart for gasoline used for research, development or...

77 FR 29847 - Redelegation of Authority for the Office of Policy Development and Research

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... Redelegation of Authority for the Office of Policy Development and Research; Order of Succession for the Office of Policy Development and Research; Notice #0;#0;Federal Register / Vol. 77 , No. 97 / Friday, May 18...] Redelegation of Authority for the Office of Policy Development and Research AGENCY: Office of the Assistant...

Alternative Fuels Data Center: Research and Development of Electricity as a

Science.gov Websites

Vehicle Fuel Research and Development of Electricity as a Vehicle Fuel to someone by E-mail Share Alternative Fuels Data Center: Research and Development of Electricity as a Vehicle Fuel on Facebook Tweet about Alternative Fuels Data Center: Research and Development of Electricity as a Vehicle

Developing Mathematics Problems Based on PISA Level of Change and Relationships Content

ERIC Educational Resources Information Center

Ahyan, Shahibul; Zulkardi; Darmawijoyo

2014-01-01

This research aims to produce mathematics problems based on PISA level with valid and practical content of change and relationships and has potential effect for Junior High School students. A development research method developed by Akker, Gravemeijer, McKenney and Nieveen is used this research. This development research consists of three stages;…

Critical Practitioners, Developing Researchers: The Story of Practitioner Research in the Lifelong Learning Sector

ERIC Educational Resources Information Center

Hillier, Yvonne

2010-01-01

This article examines the growth of practitioner research in England through the creation of the Learning and Skills Research Network (LSRN) and identifies its effect on subsequent developments in what is generally known as the Lifelong Learning Sector (LLS). It offers an analysis of this development as a case study in developing practitioner…

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2013 CFR

2013-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2011 CFR

2011-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2010 CFR

2010-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2014 CFR

2014-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2012 CFR

2012-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

40 CFR 80.1000 - What are the requirements for obtaining an exemption for gasoline used for research, development...

Code of Federal Regulations, 2010 CFR

2010-07-01

... obtaining an exemption for gasoline used for research, development or testing purposes? 80.1000 Section 80... obtaining an exemption for gasoline used for research, development or testing purposes? Gasoline used for research, development or testing purposes is exempt from the requirements of this subpart if it is exempted...

How does investment in research training affect the development of research networks and collaborations?

PubMed

Paina, Ligia; Ssengooba, Freddie; Waswa, Douglas; M'imunya, James M; Bennett, Sara

2013-05-20

Whether and how research training programs contribute to research network development is underexplored. The Fogarty International Center (FIC) has supported overseas research training programs for over two decades. FIC programs could provide an entry point in the development of research networks and collaborations. We examine whether FIC's investment in research training contributed to the development of networks and collaborations in two countries with longstanding FIC investments - Uganda and Kenya - and the factors which facilitated this process. As part of two case studies at Uganda's Makerere University and Kenya's University of Nairobi, we conducted 53 semi-structured in-depth interviews and nine focus group discussions. To expand on our case study findings, we conducted a focused bibliometric analysis on two purposively selected topic areas to examine scientific productivity and used online network illustration tools to examine the resulting network structures. FIC support made important contributions to network development. Respondents from both Uganda and Kenya confirmed that FIC programs consistently provided trainees with networking skills and exposure to research collaborations, primarily within the institutions implementing FIC programs. In both countries, networks struggled with inclusiveness, particularly in HIV/AIDS research. Ugandan respondents perceived their networks to be more cohesive than Kenyan respondents did. Network cohesiveness was positively correlated with the magnitude and longevity of FIC's programs. Support from FIC grants to local and regional research network development and networking opportunities, such as conferences, was rare. Synergies between FIC programs and research grants helped to solidify and maintain research collaborations. Networks developed where FIC's programs focused on a particular institution, there was a critical mass of trainees with similar interests, and investments for network development were available from early implementation. Networks were less likely to emerge where FIC efforts were thinly scattered across multiple institutions. The availability of complementary research grants created opportunities for researchers to collaborate in grant writing, research implementation, and publications. FIC experiences in Uganda and Kenya showcase the important role of research training programs in creating and sustaining research networks. FIC programs should consider including support to research networks more systematically in their capacity development agenda.

General practices as emergent research organizations: a qualitative study into organizational development.

PubMed

Macfarlane, Fraser; Shaw, Sara; Greenhalgh, Trisha; Carter, Yvonne H

2005-06-01

An increasing proportion of research in primary care is locally undertaken in designated research practices. Capacity building to support high quality research at these grass roots is urgently needed and is a government priority. There is little previously published research on the process by which GP practices develop as research organizations or on their specific support needs at organizational level. Using in-depth qualitative interviews with 28 key informants in 11 research practices across the UK, we explored their historical accounts of the development of research activity. We analysed the data with reference to contemporary theories of organizational development. Participants identified a number of key events and processes, which allowed us to produce a five-phase model of practice development in relation to research activity (creative energy, concrete planning, transformation/differentiation, consolidation and collaboration). Movement between these phases was not linear or continuous, but showed emergent and adaptive properties in which specific triggers and set-backs were often critical. This developmental model challenges previous categorical taxonomies of research practices. It forms a theory-driven framework for providing appropriate support at the grass roots of primary care research, based on the practice's phase of development and the nature of external triggers and potential setbacks. Our findings have important implications for the strategic development of practice-based research in the UK, and could serve as a model for the wider international community.

Undergraduate students' development of social, cultural, and human capital in a networked research experience

NASA Astrophysics Data System (ADS)

Thompson, Jennifer Jo; Conaway, Evan; Dolan, Erin L.

2016-12-01

Recent calls for reform in undergraduate biology education have emphasized integrating research experiences into the learning experiences of all undergraduates. Contemporary science research increasingly demands collaboration across disciplines and institutions to investigate complex research questions, providing new contexts and models for involving undergraduates in research. In this study, we examined the experiences of undergraduates participating in a multi-institution and interdisciplinary biology research network. Unlike the traditional apprenticeship model of research, in which a student participates in research under the guidance of a single faculty member, students participating in networked research have the opportunity to develop relationships with additional faculty and students working in other areas of the project, at their own and at other institutions. We examined how students in this network develop social ties and to what extent a networked research experience affords opportunities for students to develop social, cultural, and human capital. Most studies of undergraduate involvement in science research have focused on documenting student outcomes rather than elucidating how students gain access to research experiences or how elements of research participation lead to desired student outcomes. By taking a qualitative approach framed by capital theories, we have identified ways that undergraduates utilize and further develop various forms of capital important for success in science research. In our study of the first 16 months of a biology research network, we found that undergraduates drew upon a combination of human, cultural, and social capital to gain access to the network. Within their immediate research groups, students built multidimensional social ties with faculty, peers, and others, yielding social capital that can be drawn upon for information, resources, and support. They reported developing cultural capital in the form of learning to think and work like a scientist—a scientific habitus. They reported developing human capital in the forms of technical, analytical, and communication skills in scientific research. Most of the students had little, direct interaction with network members in other research groups and thus developed little cross-institutional capital. The exception to this trend was at one institution that housed three research groups. Because proximity facilitated shared activities, students across research groups at this institution developed cross-lab ties with faculty and peers through which they developed social, cultural, and human capital. An important long-term concern is whether the capital students have developed will help them access opportunities in science beyond the network. At this point, many undergraduates have had limited opportunities to actually draw on capital beyond the network. Nevertheless, a number of students demonstrated awareness that they had developed resources that they could use in other scientific contexts.

48 CFR 235.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and Development Centers. 235.017 Section 235.017 Federal Acquisition Regulations System DEFENSE... DEVELOPMENT CONTRACTING 235.017 Federally Funded Research and Development Centers. (a) Policy. (2) No DoD... Funded Research and Development Center (FFRDC) if a member of its board of directors or trustees...

48 CFR 235.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... and Development Centers. 235.017 Section 235.017 Federal Acquisition Regulations System DEFENSE... DEVELOPMENT CONTRACTING 235.017 Federally Funded Research and Development Centers. (a) Policy. (2) No DoD... Funded Research and Development Center (FFRDC) if a member of its board of directors or trustees...

48 CFR 235.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and Development Centers. 235.017 Section 235.017 Federal Acquisition Regulations System DEFENSE... DEVELOPMENT CONTRACTING 235.017 Federally Funded Research and Development Centers. (a) Policy. (2) No DoD... Funded Research and Development Center (FFRDC) if a member of its board of directors or trustees...

48 CFR 235.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... and Development Centers. 235.017 Section 235.017 Federal Acquisition Regulations System DEFENSE... DEVELOPMENT CONTRACTING 235.017 Federally Funded Research and Development Centers. (a) Policy. (2) No DoD... Funded Research and Development Center (FFRDC) if a member of its board of directors or trustees...

48 CFR 235.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... and Development Centers. 235.017 Section 235.017 Federal Acquisition Regulations System DEFENSE... DEVELOPMENT CONTRACTING 235.017 Federally Funded Research and Development Centers. (a) Policy. (2) No DoD... Funded Research and Development Center (FFRDC) if a member of its board of directors or trustees...

Laboratory Directed Research and Development FY-10 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dena Tomchak

2011-03-01

The FY 2010 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL -- it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

Ongoing research in occupational health and environmental epidemiology in developing countries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levy, B.S.; Kjellstrom, T.; Forget, G.

Research in occupational health and environmental epidemiology can play an important role in furthering our understanding of occupational and environmental health problems. Research guides us in the recognition, management, and prevention of health problems. However, in developing countries, where rates of occupational and environmental illnesses and injuries are higher and where these problems are often more severe than in developed countries, research capabilities are less developed. In mid-1990, a project was undertaken to (a) document ongoing research in occupational health and environmental epidemiology in developing countries, (b) facilitate the exchange of information among researchers in this field, (c) stimulate research,more » and (d) avoid unnecessary duplication among researchers in this field. A questionnaire was mailed, the purpose of which was to learn the current status of research in developing countries and to develop a directory of such ongoing research. The questionnaire was sent to 1,528 individuals. Of the 500 research projects identified, 77% were investigating chemical hazards; 26%, physical hazards; 10%, biological hazards; 10%, psychosocial hazards (some projects addressed multiple hazards). The chemical hazards studied most frequently were dusts, pesticides, and lead. The greatest number of research projects were identified in China, India, Brazil, Korea, and Thailand. Most projects were descriptive or cross-sectional epidemiologic studies or industrial hygiene or exposure-assessment studies. The World Health Organization has published a directory of the specific research projects that were identified in this survey.« less

78 FR 64932 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

... DEPARTMENT OF ENERGY Biomass Research and Development Technical Advisory Committee AGENCY: Energy... announces an open meeting of the Biomass Research and Development Technical Advisory Committee under Section... allow for public participation. This notice announces the meeting of the Biomass Research and...

7 CFR 924.45 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... establishment of production research, and marketing research and development projects designed to assist... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 924.45 Section 924.45 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

7 CFR 984.46 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the Secretary, may establish or provide for the establishment of production research, marketing research and development projects, and marketing promotion, including paid advertising, designed to assist... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 984.46 Section 984.46...

75 FR 4573 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-28

... clever new method developed by National Institute of Dental and Craniofacial Research (NIDCR) researchers... of Federally funded research and development. Foreign patent applications are filed on selected... of Invention: Researchers at the National Institutes of Health have recently developed a novel method...

Assessing research activity and capacity of community-based organizations: development and pilot testing of an instrument.

PubMed

Humphries, Debbie L; Carroll-Scott, Amy; Mitchell, Leif; Tian, Terry; Choudhury, Shonali; Fiellin, David A

2014-01-01

Although awareness of the importance of the research capacity of community-based organizations (CBOs) is growing, a uniform framework of the research capacity domains within CBOs has not yet been developed. To develop a framework and instrument (the Community REsearch Activity assessment Tool [CREAT]) for assessing the research activity and capacity of CBOs that incorporates awareness of the different data collection and analysis priorities of CBOs. We conducted a review of existing tools for assessing research capacity to identify key capacity domains. Instrument items were developed through an iterative process with CBO representatives and community researchers. The CREAT was then pilot tested with 30 CBOs. The four primary domains of the CREAT framework include 1) organizational support for research, 2) generalizable experiences, 3) research specific experiences, and 4) funding. Organizations reported a high prevalence of activities in the research-specific experiences domain, including conducting literature reviews (70%), use of research terminology (83%), and primary data collection (100%). Respondents see research findings as important to improve program and service delivery, and to seek funds for new programs and services. Funders, board members, and policymakers are the most important dissemination audiences. The work reported herein advances the field of CBO research capacity by developing a systematic framework for assessing research activity and capacity relevant to the work of CBOs, and by developing and piloting an instrument to assess activity in these domains.

Directory of Rural Development Researchers in the South. SRDC Series Publication #68.

ERIC Educational Resources Information Center

Southern Rural Development Center, Mississippi State, MS.

The directory of rural development researchers in the South first lists researchers by state for the 13 southern states and Puerto Rico, then by subject area. Research projects (25) of the Southern Rural Development Center since 1975 are also listed. The listing by state covers Alabama (31 researchers), Arkansas (12), Florida (10), Georgia (15),…

Applying the cube model to pediatric psychology: development of research competency skills at the doctoral level.

PubMed

Madan-Swain, Avi; Hankins, Shirley L; Gilliam, Margaux Barnes; Ross, Kelly; Reynolds, Nina; Milby, Jesse; Schwebel, David C

2012-03-01

This article considers the development of research competencies in professional psychology and how that movement might be applied to training in pediatric psychology. The field of pediatric psychology has a short but rich history, and experts have identified critical competencies. However, pediatric psychology has not yet detailed a set of research-based competencies. This article initially reviews the competency initiative in professional psychology, including the cube model as it relates to research training. Next, we review and adapt the knowledge-based/foundational and applied/functional research competencies proposed by health psychology into a cube model for pediatric psychology. We focus especially on graduate-level training but allude to its application throughout professional development. We present the cube model as it is currently being applied to the development of a systematic research competency evaluation for graduate training at our medical/clinical psychology doctoral program at the University of Alabama at Birmingham. Based on the review and synthesis of the literature on research competency in professional psychology we propose future initiatives to develop these competencies for the field of pediatric psychology. The cube model can be successfully applied to the development of research training competencies in pediatric psychology. Future research should address the development, implementation, and assessment of the research competencies for training and career development of future pediatric psychologists.

Setting and meeting priorities in Indigenous health research in Australia and its application in the Cooperative Research Centre for Aboriginal health.

PubMed

Monk, Johanna M; Rowley, Kevin G; Anderson, Ian Ps

2009-11-20

Priority setting is about making decisions. Key issues faced during priority setting processes include identifying who makes these decisions, who sets the criteria, and who benefits. The paper reviews the literature and history around priority setting in research, particularly in Aboriginal health research. We explore these issues through a case study of the Cooperative Research Centre for Aboriginal Health (CRCAH)'s experience in setting and meeting priorities.Historically, researchers have made decisions about what research gets done. Pressures of growing competition for research funds and an increased public interest in research have led to demands that appropriate consultation with stakeholders is conducted and that research is of benefit to the wider society. Within Australian Aboriginal communities, these demands extend to Aboriginal control of research to ensure that Aboriginal priorities are met.In response to these demands, research priorities are usually agreed in consultation with stakeholders at an institutional level and researchers are asked to develop relevant proposals at a project level. The CRCAH's experience in funding rounds was that scientific merit was given more weight than stakeholders' priorities and did not necessarily result in research that met these priorities. After reviewing these processes in 2004, the CRCAH identified a new facilitated development approach. In this revised approach, the setting of institutional priorities is integrated with the development of projects in a way that ensures the research reflects stakeholder priorities.This process puts emphasis on identifying projects that reflect priorities prior to developing the quality of the research, rather than assessing the relevance to priorities and quality concurrently. Part of the CRCAH approach is the employment of Program Managers who ensure that stakeholder priorities are met in the development of research projects. This has enabled researchers and stakeholders to come together to collaboratively develop priority-driven research. Involvement by both groups in project development has been found to be essential in making decisions that will lead to robust and useful research.

Teaching professional development of science and engineering professors at a research-extensive university: Motivations, meaningfulness, obstacles, and effects

NASA Astrophysics Data System (ADS)

Bouwma-Gearhart, Jana

There is a national movement to improve undergraduate science, technology, engineering, and mathematics (STEM) education. Given the percentage of academics teaching and training at research institutions, there is a parallel movement to improve the quality of teaching-focused professional development for practicing and future STEM educators at these institutions. While research into the effectiveness of teaching professional development at the postsecondary level has increased over the last 40 years, little attention has been paid to understanding faculty perceptions regarding what constitutes effective teaching professional development. Less is known about how to best meet the needs of STEM faculty at research universities and why, given that they are seldom required to engage in teaching professional development, they bother to participate at all. The higher education research community must develop theory grounded in the knowledge and practical experiences of the faculty engaged in teaching professional development. I have studied what motivates twelve research university science and engineering faculty to engage in teaching professional development in light of local supports and barriers and the resulting value of their participation. I have interpreted the experiences of my research participants to indicate that they were motivated to engage in teaching professional development to fulfill a need to bring their teaching competencies in better concordance with their professional strengths as researchers. Once engaged, my research participants increased their teaching competence and achieved more autonomy with respect to their professional practice. As they continued to engage, they internalized the values and practices associated with effective teaching professional development and adopted the commitment to continually problematize their teaching practice as more of their own. My research participants attempted to transfer their revised stance regarding teaching and teaching professional development to their student mentees and colleagues. They found certain teaching professional development types and topics to be more meaningful and of interest than others. My research findings may inform those committed to the improvement of postsecondary STEM education at research universities, including teaching professional development advocates and implementers and participating faculty members themselves.

Health research, development and innovation in England from 1988 to 2013: from research production to knowledge mobilization.

PubMed

Walshe, Kieran; Davies, Huw T O

2013-10-01

This paper presents a critical analysis of the development of government policy and practice on health research, development and innovation over the last 25 years - starting from the publication of a seminal report from the House of Lords Science and Technology Committee in 1988. We first set out to map and analyse the trends in ideas and thinking that have shaped research policy and practice over this period, and to put the development of health research, development and innovation in the wider context of health system reforms and changes. We argue that though this has been a transformative period for health research, rather less progress has been made in the domains of development and innovation, and we offer an analysis of why this might be the case. Drawing on advances in our understanding about how research informs practice, we then make the case for a more integrative model of research, development and innovation. This leads us to conclude that recent experiments with Collaborations for Leadership in Applied Health Research and Care and Academic Health Science Centres and Networks offer some important lessons for future policy directions.

A Review and Critique of Rural Development Research in the Land-Grant System Since 1970--with Focus upon the South. SRDC Series 65.

ERIC Educational Resources Information Center

Beaulieu, Lionel J.; Voth, Donald E.

An overview of rural development research in the United States Department of Agriculture's land grant environment focuses on southern 1862 and 1890 institutions. Although important to agricultural experiment stations, rural development research has received limited funding. A heterogeneous research program including human resources development,…

Development of a structured undergraduate research experience: Framework and implications.

PubMed

Brown, Anne M; Lewis, Stephanie N; Bevan, David R

2016-09-10

Participating in undergraduate research can be a pivotal experience for students in life science disciplines. Development of critical thinking skills, in addition to conveying scientific ideas in oral and written formats, is essential to ensuring that students develop a greater understanding of basic scientific knowledge and the research process. Modernizing the current life sciences research environment to accommodate the growing demand by students for experiential learning is needed. By developing and implementing a structured, theory-based approach to undergraduate research in the life sciences, specifically biochemistry, it has been successfully shown that more students can be provided with a high-quality, high-impact research experience. The structure of this approach allowed students to develop novel, independent projects in a computational molecular modeling lab. Students engaged in an experience in which career goals, problem-solving skills, time management skills, and independence in a research lab were developed. After experiencing this approach to undergraduate research, students reported feeling challenged to think critically and prepared for future career paths. The approach allowed for a progressive learning environment where more undergraduate students could participate in publishable research. Future areas for development include implementation in a bench-top lab and extension to disciplines beyond biochemistry. In this study, it has been shown that utilizing the structured approach to undergraduate research could allow for more students to experience undergraduate research and develop into more confident, independent life scientists well prepared for graduate schools and professional research environments. © 2016 by The International Union of Biochemistry and Molecular Biology, 44(5):463-474, 2016. © 2016 The International Union of Biochemistry and Molecular Biology.

75 FR 30804 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-02

... DEPARTMENT OF ENERGY Biomass Research and Development Technical Advisory Committee AGENCY.... SUMMARY: This notice announces an open meeting of the Biomass Research and Development Technical Advisory... Register to allow for public participation. This notice announces the meeting of the Biomass Research and...

77 FR 64970 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy Biomass Research and... Biomass Research and Development Technical Advisory Committee. The Federal Advisory Committee Act (Pub. L... Meeting: To provide advice and guidance that promotes research and development leading to the production...

7 CFR 959.48 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-01-01

... approval of the Secretary, may establish or provide for the establishment of production research, marketing research, and development projects designed to assist, improve, or promote the marketing, distribution... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 959.48 Section 959.48...

75 FR 56525 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-16

... DEPARTMENT OF ENERGY Biomass Research and Development Technical Advisory Committee AGENCY.... SUMMARY: This notice announces an open meeting of the Biomass Research and Development Technical Advisory... Register to allow for public participation. This notice announces the meeting of the Biomass Research and...

75 FR 11526 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... DEPARTMENT OF ENERGY Biomass Research and Development Technical Advisory Committee AGENCY.... SUMMARY: This notice announces an open meeting of the Biomass Research and Development Technical Advisory... Register to allow for public participation. This notice announces the meeting of the Biomass Research and...

76 FR 46781 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy Biomass Research and Development...: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Biomass Research and... meeting of the Biomass Research and Development Technical Advisory Committee. DATES and Times: August 23...

48 CFR 35.009 - Subcontracting research and development effort.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.009 Subcontracting research and development effort. Since the selection of R&D contractors is substantially based on... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontracting research...

48 CFR 970.3501 - Federally funded research and development centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Development Contracting 970.3501 Federally funded research and development centers. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Federally funded research and development centers. 970.3501 Section 970.3501 Federal Acquisition Regulations System DEPARTMENT...

North–south collaboration and capacity development in global health research in low- and middle-income countries – the ARCADE projects

PubMed Central

Atkins, Salla; Marsden, Sophie; Diwan, Vishal; Zwarenstein, Merrick

2016-01-01

Background Research capacity enhancement is needed in low- and middle-income countries (LMICs) for improved health, wellbeing, and health systems’ development. In this article, we discuss two capacity-building projects, the African/Asian Regional Capacity Development (ARCADE) in Health Systems and Services Research (HSSR) and Research on Social Determinants of Health (RSDH), implemented from 2011 to 2015. The two projects focussed on providing courses in HSSR and social determinants of health research, and on developing collaborations between universities, along with capacity in LMIC universities to manage research grant submissions, financing, and reporting. Both face-to-face and sustainable online teaching and learning resources were used in training at higher postgraduate levels (Masters and Doctoral level). Design We collated project meeting and discussion minutes along with project periodic reports and deliverables. We extracted key outcomes from these, reflected on these in discussions, and summarised them for this paper. Results Nearly 55 courses and modules were developed that were delivered to over 920 postgraduate students in Africa, Asia, and Europe. Junior researchers were mentored in presenting, developing, and delivering courses, and in preparing research proposals. In total, 60 collaborative funding proposals were prepared. The consortia also developed institutional capacity in research dissemination and grants management through webinars and workshops. Discussion ARCADE HSSR and ARCADE RSDH were comprehensive programmes, focussing on developing the research skills, knowledge, and capabilities of junior researchers. One of the main strengths of these programmes was the focus on network building amongst the partner institutions, where each partner brought skills, expertise, and diverse work cultures into the consortium. Through these efforts, the projects improved both the capacity of junior researchers and the research environment in Africa, Asia, and Europe. PMID:27725081

North-south collaboration and capacity development in global health research in low- and middle-income countries - the ARCADE projects.

PubMed

Atkins, Salla; Marsden, Sophie; Diwan, Vishal; Zwarenstein, Merrick

2016-01-01

Research capacity enhancement is needed in low- and middle-income countries (LMICs) for improved health, wellbeing, and health systems' development. In this article, we discuss two capacity-building projects, the African/Asian Regional Capacity Development (ARCADE) in Health Systems and Services Research (HSSR) and Research on Social Determinants of Health (RSDH), implemented from 2011 to 2015. The two projects focussed on providing courses in HSSR and social determinants of health research, and on developing collaborations between universities, along with capacity in LMIC universities to manage research grant submissions, financing, and reporting. Both face-to-face and sustainable online teaching and learning resources were used in training at higher postgraduate levels (Masters and Doctoral level). We collated project meeting and discussion minutes along with project periodic reports and deliverables. We extracted key outcomes from these, reflected on these in discussions, and summarised them for this paper. Nearly 55 courses and modules were developed that were delivered to over 920 postgraduate students in Africa, Asia, and Europe. Junior researchers were mentored in presenting, developing, and delivering courses, and in preparing research proposals. In total, 60 collaborative funding proposals were prepared. The consortia also developed institutional capacity in research dissemination and grants management through webinars and workshops. ARCADE HSSR and ARCADE RSDH were comprehensive programmes, focussing on developing the research skills, knowledge, and capabilities of junior researchers. One of the main strengths of these programmes was the focus on network building amongst the partner institutions, where each partner brought skills, expertise, and diverse work cultures into the consortium. Through these efforts, the projects improved both the capacity of junior researchers and the research environment in Africa, Asia, and Europe.

The Crop Growth Research Chamber - A ground-based facility for CELSS research

NASA Technical Reports Server (NTRS)

Bubenheim, David L.; Luna, Phil M.; Wagenbach, Kimberly M.; Haslerud, Mark; Straight, Christian L.

1989-01-01

Crop Growth Research Chambers (CGRCs) are being developed as CELSS research facilities for the NASA/Ames Research Center. The history of the CGRC project is reviewed, noting the applications of CGRC research for the development of the Space Station. The CGRCs are designed for CELSS research and development, system control and integration, and flight hardware design and experimentation. The atmospheric and hydroponic environments of the CGRC system are described and the science requirements for CGRC environmental control are listed.

Occupational Health Research in Developing Countries: A Partner for Social Justice

PubMed Central

Nuwayhid, Iman A.

2004-01-01

Occupational health remains neglected in developing countries because of competing social, economic, and political challenges. Occupational health research in developing countries should recognize the social and political context of work relations, especially the fact that the majority of developing countries lack the political mechanisms to translate scientific findings into effective policies. Researchers in the developing world can achieve tangible progress in promoting occupational health only if they end their professional isolation and examine occupational health in the broader context of social justice and national development in alliance with researchers from other disciplines. An occupational health research paradigm in developing countries should focus less on the workplace and more on the worker in his or her social context. PMID:15514227

Researcher development program of the primary health care research, evaluation and development strategy.

PubMed

McIntyre, Ellen; Brun, Lyn; Cameron, Helen

2011-01-01

The Research Development Program (RDP) was initiated in 2004 under the Primary Health Care Research, Evaluation and Development (PHCRED) Strategy to increase the number and range of people with knowledge and skills in primary health care research and evaluation. RDP Fellows were invited to participate in an online survey about the effect the program had on their research knowledge, attitudes and practice. The response rate was 42% (105/248). Most were female (88%) with 66% aged between 31 and 50 years. Over two-thirds (72%) were health practitioners. Activities undertaken during the RDP ranged from literature reviews, developing a research question, preparing ethics submissions, attending and presenting at conferences and seminars, preparing papers and reports, and submitting grant applications. Despite the fact that only 52% agreed that the RDP time was adequate, 94% agreed that the RDP was a valuable experience, with 89% expressing interest in undertaking further research. These results indicate that this program has had a positive effect on the RDP Fellows in terms of their knowledge about research, their attitude to research, and the way they use research in their work.

Building the Science of Research Management: What Can Research Management Learn from Education Research?

ERIC Educational Resources Information Center

Huang, Jun Song; Hung, Wei Loong

2018-01-01

Research management is an emerging field of study and its development is significant to the advancement of research enterprise. Developing the science of research management requires investigating social mechanisms involved in research management. Yet, studies on social mechanisms of research management is lacking in the literature. To address…

How International Research on Parenting Advances Understanding of Child Development

PubMed Central

Lansford, Jennifer E.; Bornstein, Marc H.; Deater-Deckard, Kirby; Dodge, Kenneth A.; Al-Hassan, Suha M.; Bacchini, Dario; Bombi, Anna Silvia; Chang, Lei; Chen, Bin-Bin; Di Giunta, Laura; Malone, Patrick S.; Oburu, Paul; Pastorelli, Concetta; Skinner, Ann T.; Sorbring, Emma; Steinberg, Laurence; Tapanya, Sombat; Alampay, Liane Peña; Tirado, Liliana Maria Uribe; Zelli, Arnaldo

2016-01-01

International research on parenting and child development can advance our understanding of similarities and differences in how parenting is related to children's development across countries. Challenges to conducting international research include operationalizing culture, disentangling effects within and between countries, and balancing emic and etic perspectives. Benefits of international research include testing whether findings regarding parenting and child development replicate across diverse samples, incorporating cultural and contextual diversity to foster more inclusive and representative research samples and investigators than has typically occurred, and understanding how children develop in proximal parenting and family and distal international contexts. PMID:27725843

76 FR 22091 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy Biomass Research and Development...: Notice of Open Meeting. SUMMARY: This notice announces an open meeting of the Biomass Research and...: Purpose of Committee: To provide advice and guidance that promotes research and development leading to the...

78 FR 47049 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development...; 5 U.S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and.... Name: Research, Engineering & Development Advisory Committee. Time and Date: September 18--8:30 a.m. to...

77 FR 20377 - Biomass Research and Development Technical Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-04

... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy Biomass Research and... Biomass Research and Development Technical Advisory Committee under Section 9008(d) of the Food... procedures, members of the public are welcome to observe the business of the Biomass Research and Development...

Standards for Reporting Mathematics Professional Development in Research Studies

ERIC Educational Resources Information Center

Sztajn, Paola

2011-01-01

This Research Commentary addresses the need for standards for describing mathematics professional development in mathematics education research reports. Considering that mathematics professional development is an emerging research field, it is timely to set expectations for what constitutes high-quality reporting in this field. (Contains 2 tables.)

Linear- and Repetitive-Feature Detection Within Remotely Sensed Imagery

DTIC Science & Technology

2017-04-01

public release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest...Imagery Brendan West U.S. Army Engineer Research and Development Center (ERDC) Cold Regions Research and Engineering Laboratory (CRREL) 72 Lyme Road...and Intelligence System (ARTEMIS) U.S. Army Engineer Research and Development Center (ERDC) Cold Regions Research and Engineering Laboratory (CRREL

The economic impact of NASA R and D spending: Executive summary

NASA Technical Reports Server (NTRS)

Evans, M. K.

1976-01-01

An evaluation of the economic impact of NASA research and development programs is made. The methodology and the results revolve around the interrelationships existing between the demand and supply effects of increased research and development spending, in particular, NASA research and development spending. The INFORUM Inter-Industry Forecasing Model is used to measure the short-run economic impact of alternative levels of NASA expenditures for 1975. An aggregate production function approach is used to develop the data series necessary to measure the impact of NASA research and development spending, and other determinants of technological progress, on the rate of growth in productivity of the U. S. economy. The measured relationship between NASA research and development spending and technological progress is simulated in the Chase Macroeconometric Model to measure the immediate, intermediate, and long-run economic impact of increased NASA research and development spending over a sustained period.

The Social Value of Knowledge and International Clinical Research.

PubMed

Wenner, Danielle M

2015-08-01

In light of the growth in the conduct of international clinical research in developing populations, this paper seeks to explore what is owed to developing world communities who host international clinical research. Although existing paradigms for assigning and assessing benefits to host communities offer valuable insight, I criticize their failure to distinguish between those benefits which can justify the conduct of research in a developing world setting and those which cannot. I argue that the justification for human subjects research is fundamentally grounded in the social value of knowledge, and that this value is context-dependent in a manner which should inform our ethical evaluation of the conduct of research in specific settings. I propose a new framework for the assessment of research benefits assigned to developing world host communities, a natural implication of which is to limit the types of research projects which may permissibly be conducted in developing world settings. © 2013 John Wiley & Sons Ltd.

Aircraft Measurements of BrO, IO, Glyoxal, NO2, H2O, O2-O2 and Aerosol Extinction Profiles in the Tropics: Comparison with Aircraft-/Ship-Based in Situ and Lidar Measurements

NASA Technical Reports Server (NTRS)

Volkamer, R.; Baidar, S.; Campos, T. L.; Coburn, S.; DiGangi, J. P.; Dix, B.; Eloranta, E. W.; Koenig, T. K.; Morley, B.; Ortega, I.;

The ''Complex Reality'' of Research Capacity Development in Mathematics Education in Southern African Development Community Countries

ERIC Educational Resources Information Center

Julie, Cyril; Mikalsen, Oyvind; Persens, Jan

2005-01-01

This paper explores how an aid-funded Ph.D.-programme in mathematics education instituted in some Southern African Development Community countries measures up to issues related to research capacity development projects. The research capacity development programme is described and reflected against mutual benefit, relevance, sustainability and…

23 CFR 420.107 - What is the minimum required expenditure of State planning and research funds for research...

Code of Federal Regulations, 2010 CFR

2010-04-01

... planning and research funds for research development and technology transfer? 420.107 Section 420.107 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING AND... minimum required expenditure of State planning and research funds for research development and technology...

A Study of Facilities and Infrastructure Planning, Prioritization, and Assessment at Federal Security Laboratories

DTIC Science & Technology

2012-11-01

Research , Development, Test , and Evaluation (RDT&E) Appropriations The RDT&E appropriation consists of the mission program budgets for all... research , development, test and evaluation work performed by contractors and government installations and includes an installations and activities budget...than $4,000,000. 9 f. Research , Development, Test , and Evaluation Appropriations The Research , Development, Test , and Evaluation (RDT&E

Development and Testing of a M-Learning System for the Professional Development of Academics through Design-Based Action Research

ERIC Educational Resources Information Center

Keskin, Nilgun Ozdamar; Kuzu, Abdullah

2015-01-01

In the present study, a mobile learning system for the professional development of academics was developed by design based action research, and the perceptions and experiences of the academics using this system were examined. In the first phase of this design-based action research, the research question was defined. In the second phase, a…

Mobility Research and Development (Briefing charts)

DTIC Science & Technology

2016-03-17

Mobility Research & Development Dr. Paramsothy Jayakumar, STE, Analytics Tank Automotive Research, Development and Engineering Center Research...Mobility Model (NRMM) • Dr. M. G. Bekker of TARDEC is the “Father of Terrain-Vehicle Systems ” • NRMM was developed in 1960-70 by TARDEC and ERDC...Blocks: Scaled Experiments Particle Image Velocimetry Pressure – Sinkage Test Direct Shear Test Simulations Single Wheel Test Plate width = 50 mm

The Development of Open University New Generation Learning Model Using Research and Development for Atomic Physics Course PEFI4421

ERIC Educational Resources Information Center

Prayekti

2017-01-01

This research was aimed at developing printed teaching materials of Atomic Physics PEFI4421 Course using Research and Development (R & D) model; which consisted of three major set of activities. The first set consisted of seven stages, the second set consisted of one stage, and the third set consisted of seven stages. This research study was…

Organizational Issues and Human Resource Development Research Questions. A Guide for Researchers in Human Resource Development.

ERIC Educational Resources Information Center

Jacobs, Ronald L., Ed.

The nine papers in this monograph, written by members of the University Council for Research in Human Resource Development, respond to the following questions: What is the most important organizational issue of the 1990s, and what human resource development (HRD) research questions might be generated from this issue? The papers are as follows: (1)…

Integrative Curriculum Development in Nuclear Education and Research Vertical Enhancement Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Egarievwe, Stephen U.; Jow, Julius O.; Edwards, Matthew E.

Using a vertical education enhancement model, a Nuclear Education and Research Vertical Enhancement (NERVE) program was developed. The NERVE program is aimed at developing nuclear engineering education and research to 1) enhance skilled workforce development in disciplines relevant to nuclear power, national security and medical physics, and 2) increase the number of students and faculty from underrepresented groups (women and minorities) in fields related to the nuclear industry. The program uses multi-track training activities that vertically cut across the several education domains: undergraduate degree programs, graduate schools, and post-doctoral training. In this paper, we present the results of an integrativemore » curriculum development in the NERVE program. The curriculum development began with nuclear content infusion into existing science, engineering and technology courses. The second step involved the development of nuclear engineering courses: 1) Introduction to Nuclear Engineering, 2) Nuclear Engineering I, and 2) Nuclear Engineering II. The third step is the establishment of nuclear engineering concentrations in two engineering degree programs: 1) electrical engineering, and 2) mechanical engineering. A major outcome of the NERVE program is a collaborative infrastructure that uses laboratory work, internships at nuclear facilities, on-campus research, and mentoring in collaboration with industry and government partners to provide hands-on training for students. The major activities of the research and education collaborations include: - One-week spring training workshop at Brookhaven National Laboratory: The one-week training and workshop is used to enhance research collaborations and train faculty and students on user facilities/equipment at Brookhaven National Laboratory, and for summer research internships. Participants included students, faculty members at Alabama A and M University and research collaborators at BNL. The activities include 1) tour and introduction to user facilities/equipment at BNL that are used for research in room-temperature semiconductor nuclear detectors, 2) presentations on advances on this project and on wide band-gap semiconductor nuclear detectors in general, and 3) graduate students' research presentations. - Invited speakers and lectures: This brings collaborating research scientist from BNL to give talks and lectures on topics directly related to the project. Attendance includes faculty members, researchers and students throughout the university. - Faculty-students team summer research at BNL: This DOE and National Science Foundation (NSF) program help train students and faculty members in research. Faculty members go on to establish research collaborations with scientists at BNL, develop and submit research proposals to funding agencies, transform research experience at BNL to establish and enhance reach capabilities at home institution, and integrate their research into teaching through class projects and hands-on training for students. The students go on to participate in research work at BNL and at home institution, co-author research papers for conferences and technical journals, and transform their experiences into developing senior and capstone projects. - Grant proposal development: Faculty members in the NERVE program collaborate with BNL scientists to develop proposals, which often help to get external funding needed to expand and sustain the continuity of research activities and supports for student's wages and scholarships (stipends, tuition and fees). - Faculty development and mentoring: The above collaboration activities help faculty professional development. The experiences, grants, joint publications in technical journals, and supervision of student's research, including thesis and dissertation research projects, contribute greatly to faculty development. Senior scientists at BNL and senior faculty members on campus jointly mentor junior faculty members to enhance their professional growth. - Graduate thesis and dissertation research: Brookhaven National Laboratory provides unique opportunities and outstanding research resources for the NERVE program graduate research. Scientists from BNL serve in master's degree thesis and PhD dissertation committees, where they play active roles in the supervision of the research. (authors)« less

Health research capacity development in low and middle income countries: reality or rhetoric? A systematic meta-narrative review of the qualitative literature.

PubMed

Franzen, Samuel R P; Chandler, Clare; Lang, Trudie

2017-01-27

Locally led health research in low and middle income countries (LMICs) is critical for overcoming global health challenges. Yet, despite over 25 years of international efforts, health research capacity in LMICs remains insufficient and development attempts continue to be fragmented. The aim of this systematic review is to identify and critically examine the main approaches and trends in health research capacity development and consolidate key thinking to identify a more coherent approach. This review includes academic and grey literature published between January 2000 and July 2013. Using a predetermined search strategy, we systematically searched PubMed, hand-searched Google Scholar and checked reference lists. This process yielded 1668 papers. 240 papers were selected based on a priori criteria. A modified version of meta-narrative synthesis was used to analyse the papers. 3 key narratives were identified: the effect of power relations on capacity development; demand for stronger links between research, policy and practice and the importance of a systems approach. Capacity development was delivered through 4 main modalities: vertical research projects, centres of excellence, North-South partnerships and networks; all were controversial, and each had their strengths and weaknesses. A plurality of development strategies was employed to address specific barriers to health research. However, lack of empirical research and monitoring and evaluation meant that their effectiveness was unclear and learning was weak. There has been steady progress in LMIC health research capacity, but major barriers to research persist and more empirical evidence on development strategies is required. Despite an evolution in development thinking, international actors continue to use outdated development models that are recognised as ineffective. To realise newer development thinking, research capacity outcomes need to be equally valued as research outputs. While some development actors are now adopting this dedicated capacity development approach, they are in the minority. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Research during medical school: is it particularly difficult in developing countries compared to developed countries?

PubMed Central

Siddaiah-Subramanya, Manjunath; Singh, Harveen; Tiang, Kor Woi

2017-01-01

Objectives Medical student involvement in research has been declining over the years. We reviewed the factors that hinder participation in research with a focus on developing countries. Methods Literature search was performed using PubMed, MEDLINE and Cochrane Library. Peer-reviewed articles published between 1995 and 2017 were screened for relevance to identify key factors affecting medical student involvement in research with a particular focus on developing world. Analytical review is presented here in this article in relation to commonly reported aspects related to research during medical school. Results This search revealed varied contributing factors that hinder students’ growth and interest in research. It commonly highlighted few aspects in relation to research during medical school, and they were “variability in research uptake among students and issues related to them, their knowledge and attitude toward research and organizational input and its influence on students”. Conclusion While early introduction to research by inculcating a mindset aimed at research has been proposed, it has not been seen in practice during either the medical school or beyond to an extent that was expected. It appears that developing countries, while they share some of the reasons with developed countries, have their own set of difficulties, which are influenced by culture, beliefs and priorities. PMID:29180910

The Utilization of Flight Simulation for Research and Development

NASA Technical Reports Server (NTRS)

Totah, Joseph J.; Snyder, C. Thomas (Technical Monitor)

1994-01-01

The objective of this paper is to review the conventional uses of flight simulation at NASA Ames Research Center for research and development, and to also consider the many new areas that have embraced flight simulation as an effective and economic research tool. Flight simulators have always been a very useful and economic research tool. Component technologies have evolved considerably to meet demands imposed by the aerospace community. In fact, the utilization of flight simulators for research and development has become so widely accepted that non-traditional uses have evolved. Whereas flight dynamics and control, guidance and navigation, vehicle design, mission assessment, and training have been, and perhaps always will be, the most popular research areas associated with simulation, many new areas under the broad categories of human factors and information science have realized significant benefits from the use of flight simulators for research and development. This paper will survey the simulation facilities at NASA Ames Research Center, and discuss selected topics associated with research programs, simulation experiments, and related technology development activities for the purpose of highlighting the expanding role of simulation in aerospace research and development. The information in this paper will in no way provide foreign companies with a competitive advantage over U. S. industry.

A measure of community members' perceptions of the impacts of research partnerships in health and social services.

PubMed

King, Gillian; Servais, Michelle; Kertoy, Marilyn; Specht, Jacqueline; Currie, Melissa; Rosenbaum, Peter; Law, Mary; Forchuk, Cheryl; Chalmers, Heather; Willoughby, Teena

2009-08-01

Currently, there are no psychometrically sound outcome measures by which to assess the impacts of research partnerships. This article describes the development of a 33-item, survey questionnaire measuring community members' perceptions of the impact of research partnerships addressing health or social issues. The Community Impacts of Research Oriented Partnerships (CIROP) was developed using information from the literatures on health promotion, community development, research utilization, and community-based participatory research, and from focus groups involving 29 key informants. Data from 174 community members were used to determine the factor structure, internal consistency, and test-retest reliability of the four CIROP scales, and to provide evidence of construct validity. The CIROP informs research partnerships about the extent of their impact in the areas of Personal Knowledge Development, Personal Research Skill Development, Organizational/Group Access To and Use of Information, and Community and Organizational Development, allowing them to demonstrate accountability to funding bodies. As well, the CIROP can be used as a research tool to assess the effectiveness of knowledge sharing approaches, determine the most influential activities of research partnerships, and determine structural characteristics of partnerships associated with various types of impact. The CIROP provides a better understanding of community members' perspectives and expectations of research partnerships, with important implications for knowledge transfer and uptake.

Manpower Research and Development Projects; 1973 Edition.

ERIC Educational Resources Information Center

Manpower Administration (DOL), Washington, DC.

The third edition of Manpower Research and Development Projects presents descriptions of 455 projects which are grouped by subject matter to facilitate description of the research and development program and the use of the material. The 199 doctoral dissertation grants and the 12 manpower research institutional grants are classified by subject…

Society for Research in Child Development Newsletter, 2000.

ERIC Educational Resources Information Center

Reid, Pamela Trotman, Ed.

2000-01-01

This document consists of the four 2000 issues of a newsletter disseminating information on the Society for Research in Child Development (SRCD) and providing a forum for important news, research, and information concerning advancements in child growth and development research. Each issue of the newsletter provides announcements and notices of…

7 CFR 922.45 - Marketing research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Marketing research and development. 922.45 Section 922... GROWN IN DESIGNATED COUNTIES IN WASHINGTON Order Regulating Handling Research § 922.45 Marketing research and development. The committee, with the approval of the Secretary, may establish or provide for...

78 FR 78506 - Research and Development; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

.... PHMSA-2013-0261; Notice No. 13-21] Research and Development; Public Meeting AGENCY: Pipeline and... the Research and Development Forum to be held January 17, 2014, in Washington, DC. During this meeting, PHMSA will host the session to present the results of recently completed and current research projects...

7 CFR 923.45 - Marketing research and development.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Marketing research and development. 923.45 Section 923... CHERRIES GROWN IN DESIGNATED COUNTIES IN WASHINGTON Order Regulating Handling Research § 923.45 Marketing research and development. The committee, with the approval of the Secretary, may establish or provide for...

78 FR 6854 - Health Services Research and Development Service Scientific Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-31

... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Scientific Merit... Research and Development Service Scientific Merit Review Board will meet on February 13-14, 2013, at the... research. Applications are reviewed for scientific and technical merit. Recommendations regarding funding...

Applied Research in Child and Adolescent Development: A Practical Guide

ERIC Educational Resources Information Center

Maholmes, Valerie, Ed.; Lomonaco, Carmela Gina, Ed.

2010-01-01

Developed for an NIH training institute, this volume is organized around the most frequently asked questions by researchers starting their careers in applied research in child and adolescent development. With contributions from the leading scholars in the field, actual research experiences highlight the challenges one faces in conducting such…

Society for Research in Child Development Newsletter, 2002.

ERIC Educational Resources Information Center

Reid, Pamela Trotman, Ed.; Tucker, Thelma, Ed.

2002-01-01

This document consists of the four 2002 issues of a newsletter disseminating information on the Society for Research in Child Development (SRCD) and providing a forum for important news, research, and information concerning advancement in child growth and development research. Each issue of the newsletter includes announcements and notices of…

78 FR 53015 - Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative... under the Federal Advisory Committee Act, 5 U.S.C. App. 2, that the Clinical Science Research and... Clinical Science Research and Development Service on the relevance and feasibility of proposed projects and...

77 FR 72438 - Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative... under the Federal Advisory Committee Act, 5 U.S.C. App. 2, that the Clinical Science Research and... through the Director of the Clinical Science Research and Development Service on the relevance and...

78 FR 41198 - Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative... under the Federal Advisory Committee Act, 5 U.S.C. App. 2, that the Clinical Science Research and... Science Research and Development Service on the relevance and feasibility of proposed projects and the...

78 FR 3019 - Privacy Act of 1974; Science & Technology Directorate-001 Research, Development, Test, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

... biomedical and life sciences research; and subject matter experts who voluntarily consent to be included in a... 1974; Science & Technology Directorate-001 Research, Development, Test, and Evaluation Records System.../Science and Technology Directorate-001 Research, Development, Test, and Evaluation System of Records...

7 CFR 985.31 - Research and development proj-ects.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and development proj-ects. 985.31 Section 985.31 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... Research § 985.31 Research and development proj-ects. The Committee, with the approval of the Secretary...

7 CFR 985.31 - Research and development proj-ects.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research and development proj-ects. 985.31 Section 985.31 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... Research § 985.31 Research and development proj-ects. The Committee, with the approval of the Secretary...

7 CFR 985.31 - Research and development proj-ects.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Research and development proj-ects. 985.31 Section 985.31 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... Research § 985.31 Research and development proj-ects. The Committee, with the approval of the Secretary...

7 CFR 985.31 - Research and development proj-ects.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Research and development proj-ects. 985.31 Section 985.31 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... Research § 985.31 Research and development proj-ects. The Committee, with the approval of the Secretary...

Building Education Research Capacity in Developing Countries: Some Fundamental Issues

ERIC Educational Resources Information Center

Puryear, Jeffrey M.

2005-01-01

This article addresses how to develop education research capacity in developing countries, using Chile's experience as a case study. Education research capacity is defined as a productive, modern, diverse, and self-reproducing professional community conducting research at internationally acceptable levels of quality. I argue that 3 general…

Assessing and Controlling Blast Noise Emission: SARNAM Noise Impact Software

DTIC Science & Technology

2007-12-29

Engineers, Engineer Research and Development Center Jeffery Mifflin U.S. Army Corps of Engineers, Engineer Research and Development Center Kristy A...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) U.S. Army Engineer Research and Development Center (ERDC) Construction Engineering Research Laboratory...6 Figure 5. OneShot control page

Development of the Research Competencies Scale

ERIC Educational Resources Information Center

Swank, Jacqueline M.; Lambie, Glenn W.

2016-01-01

The authors present the development of the Research Competencies Scale (RCS). The purpose of this article is threefold: (a) present a rationale for the RCS, (b) review statistical analysis procedures used in developing the RCS, and (c) offer implications for counselor education, the enhancement of scholar-researchers, and future research.

Participatory Research in an Arts Integration Professional Development Program

ERIC Educational Resources Information Center

Cawthon, Stephanie W.; Dawson, Kathryn M.; Judd-Glossy, Laura; Ihorn, Shasta

2012-01-01

Drama for Schools (DFS) is an arts integration professional development program rooted in critical pedagogy and constructivism that emphasizes partnerships between school districts and a major research university. As a part of the research initiative embedded in this professional development program, DFS began an Arts integration Research Teacher…

76 FR 1212 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-07

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board Panel for Eligibility; Notice of Meeting The Department of Veterans Affairs (VA) gives notice under the Public Law 92-463 (Federal Advisory...

78 FR 28292 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board; Notice of Meetings; Amendment The Department of Veterans Affairs (VA) gives notice under the Federal Advisory Committee Act, 5 U.S.C. App...

75 FR 57833 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-22

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board; Notice of Meetings The Department of Veterans Affairs gives notice under the Public Law 92-463 (Federal Advisory Committee Act) that...

76 FR 66367 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-26

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board; Notice of Meetings The Department of Veterans Affairs gives notice under the Public Law 92-463 (Federal Advisory Committee Act) that...

77 FR 26069 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board, Notice of Meeting Amendment The Department of Veterans Affairs (VA) gives notice under the Public Law 92-463 (Federal Advisory Committee Act...

76 FR 79273 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board Panel for Eligibility, Notice of Meeting The Department of Veterans Affairs (VA) gives notice under Public Law 92-463 (Federal Advisory...

48 CFR 46.307 - Fixed-price research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.307 Fixed-price research and development... Development—Fixed-Price, in solicitations and contracts for research and development when (1) the primary... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price research and...

76 FR 46756 - Strategic Environmental Research and Development Program (SERDP), Scientific Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

... research and development projects related to the Munitions Response and Resource Conservation and Climate Change program areas. These projects are requesting Strategic Environmental Research and Development...

Regimented research: a recipe for success?

PubMed

Yu, Eric H C

2003-04-01

Cardiology trainees at the University of Toronto participate annually in a mandatory research competition. Its purpose is to promote creative thinking, help develop a greater understanding of the scientific method and encourage them to pursue research as a career. Since its inception, this research competition's outcomes have not been assessed. This study set out to determine which components of a cardiology training program are important in the development of a career in cardiovascular research and addressed whether participation in this mandatory research competition was considered important to the development of a career in cardiovascular research. This study found that both faculty and trainees considered the following factors to be important in the development of a research career: (1) a mentor to provide support and guidance; (2) regular attendance at national and international meetings; (3) a fixed block of time within the training program dedicated solely to research activity; and (4) an academic environment that provides exposure to clinicians with varied research interests and ability. Neither trainees nor faculty believed that mandatory participation in a research competition was of significant benefit in the development of a research career, although faculty's perception of such a benefit was greater than the trainees'.

An evaluation of the 'Designated Research Team' approach to building research capacity in primary care.

PubMed

Cooke, Jo; Nancarrow, Susan; Dyas, Jane; Williams, Martin

2008-06-27

This paper describes an evaluation of an initiative to increase the research capability of clinical groups in primary and community care settings in a region of the United Kingdom. The 'designated research team' (DRT) approach was evaluated using indicators derived from a framework of six principles for research capacity building (RCB) which include: building skills and confidence, relevance to practice, dissemination, linkages and collaborations, sustainability and infrastructure development. Information was collated on the context, activities, experiences, outputs and impacts of six clinical research teams supported by Trent Research Development Support Unit (RDSU) as DRTs. Process and outcome data from each of the teams was used to evaluate the extent to which the DRT approach was effective in building research capacity in each of the six principles (as evidenced by twenty possible indicators of research capacity development). The DRT approach was found to be well aligned to the principles of RCB and generally effective in developing research capabilities. It proved particularly effective in developing linkages, collaborations and skills. Where research capacity was slow to develop, this was reflected in poor alignment between the principles of RCB and the characteristics of the team, their activities or environment. One team was unable to develop a research project and the funding was withdrawn at an early stage. For at least one individual in each of the remaining five teams, research activity was sustained beyond the funding period through research partnerships and funding successes. An enabling infrastructure, including being freed from clinical duties to undertake research, and support from senior management were found to be important determinants of successful DRT development. Research questions of DRTs were derived from practice issues and several projects generated outputs with potential to change daily practice, including the use of research evidence in practice and in planning service changes. The DRT approach was effective at RCB in teams situated in a supportive organisation and in particular, where team members could be freed from clinical duties and management backing was strong. The developmental stage of the team and the research experience of constituent members also appeared to influence success. The six principles of RCB were shown to be useful as a framework for both developing and evaluating RCB initiatives.

Education for Sustainable Development Research from the Researchers' Point of View

ERIC Educational Resources Information Center

Reunamo, Jyrki; Pipere, Anita

2012-01-01

Research is not just a simple application of research methods. It is undertaken by human beings who hold personal views on the environment. The way in which the researcher sees environmental changes may have an impact on the research questions and the choice of research practices. The researcher may be a contributor to cultural development either…

Research Methods to Develop Measures of Effectiveness of the United States Coast Guard’s Vessel Inspection and Boarding Program. Executive Summary - Volume I

DTIC Science & Technology

1995-05-01

Service, Springfield, Virginia 22161 Prepared for: LJCý U.S. Coast Guard Research and Development Center 1082 Shennecossett Road < Groton, Connecticut...States Coast Guard Research & Development Center 1082 Shennecossett Road Groton, CT 06340-6096 ii Technical Report Documentation Paae 1. Report No. 2...U.S. Coast Guard 14. Sponsoring Agency Code Research and Development Center Office of Engineering, Logistics, 1082 Shennecossett Road and Development

7 CFR 966.48 - Research and promotion.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Research and promotion. 966.48 Section 966.48... Regulating Handling Research and Development § 966.48 Research and promotion. The committee may, with the... research, marketing research and development projects, and marketing promotion including paid advertising...

AN OVERVIEW OF PATHOGEN RESEARCH IN THE MICROBIOLOGICAL AND CHEMICAL EXPOSURE ASSESSMENT RESEARCH DIVISION

EPA Science Inventory

The Microbiological and Chemical Exposure Assessment Research Division of the EPA Office of Research and Development's National Exposure Research Laboratory has a robust in-house research program aimed at developing better occurrence and exposure methods for waterborne pathogens....

7 CFR 966.48 - Research and promotion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... research, marketing research and development projects, and marketing promotion including paid advertising... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and promotion. 966.48 Section 966.48... Regulating Handling Research and Development § 966.48 Research and promotion. The committee may, with the...

Ethical review of health research: a perspective from developing country researchers.

PubMed

Hyder, A A; Wali, S A; Khan, A N; Teoh, N B; Kass, N E; Dawson, L

2004-02-01

Increasing collaboration between industrialised and developing countries in human research studies has led to concerns regarding the potential exploitation of resource deprived countries. This study, commissioned by the former National Bioethics Advisory Commission of the United States, surveyed developing country researchers about their concerns and opinions regarding ethical review processes and the performance of developing country and US international review boards (IRBs). Contact lists from four international organisations were used to identify and survey 670 health researchers in developing countries. A questionnaire with 169 questions explored issues of IRB review, informed consent, and recommendations. The majority of the developing country researchers were middle aged males who were physicians and were employed by educational institutions, carrying out research on part time basis. Forty four percent of the respondents reported that their studies were not reviewed by a developing country IRB or Ministry of Health and one third of these studies were funded by the US. During the review process issues such as the need for local language consent forms and letters for approval, and confidentiality protection of participants were raised by US IRBs in significantly higher proportions than by host country IRBs. This survey indicates the need for the ethical review of collaborative research in both US and host countries. It also reflects a desire for focused capacity development in supporting ethical review of research.

The distribution of biomedical research resources and international justice.

PubMed

Resnik, David B

2004-05-01

According to some estimates, less than 10% of the world's biomedical research funds are dedicated to addressing problems that are responsible for 90% of the world's burden of disease. This paper explains why this disparity exists and what should be done about it. It argues that the disparity exists because: 1) multinational pharmaceutical and biotechnology companies do not regard research and development investments on the health problems of developing nations to be economically lucrative; and 2) governmental agencies that sponsor biomedical research face little political pressure to allocate funds for the problems of developing nations. This paper argues that developed nations have an obligation to address disparities related to biomedical research funding. To facilitate this effort, developed countries should establish a trust fund dedicated to research on the health problems of developing nations similar to the Global AIDS Fund.

Moving from institutional dependence to entrepreneurialism. Creating and funding a collaborative research and practice development position.

PubMed

Darbyshire, Philip; Downes, Maeve; Collins, Carmel; Dyer, Susan

2005-09-01

The paper describes the creation of, the rationale behind and the external funding of a collaborative research-clinical practice development position. The paper also demonstrates the benefits of nursing's collaboration with external funding bodies and the value of moving from our traditional position of assuming that 'the hospital' will always provide. There is a constant refrain that nursing must become more 'research-based' and develop an active research culture. In harsh financial times however, funding for research development is scarce. Nurses can respond to this by bemoaning the lack of money or by taking an entrepreneurial approach, creating innovative project proposals that develop new partnerships and attract external funding. Institutional support for clinical research is often more verbal than financial as most health care systems are experiencing extreme financial stringencies. Nurses need to reconsider the notion that every initiative must automatically be funded by the institution. In this paper we show how in a busy major hospital, clinicians and researchers collaborated to create and fund the kind of innovative research and practice development position that may be impossible to fund through existing budgets. With creativity and determination, nurses can challenge the orthodoxy that they are solely dependent on institutional funding. If there is a clear project vision, a convincing rationale, a strongly argued 'business case' and a passionate and persistent team, then innovative new projects and positions can be realized. Developing clinical focused, practice based research is now a worldwide policy and practice imperative for nurses. Unfortunately, current levels of institutional funding are unlikely to support research promotion positions and initiatives. This paper outlines an approach to securing funding for research initiatives that can create exciting new positions and develop productive partnerships between researchers, clinicians and external agencies.

Federal Funds for Research and Development: Fiscal Years 1981, 1982, and 1983. Volume XXXI. Detailed Statistical Tables. Surveys of Science Resources Series.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

Detailed statistical tables on federal funds for research and development (R&D) activities are provided in this document. Tables are organized into the following sections: research, development, and R&D plant; R&D- agency, character of work, and performer; total research- agency, performer, and field of science; basic research- agency,…

Federal Funds for Research and Development. Fiscal Years 1982, 1983, and 1984. Volume XXXII. Detailed Statistical Tables. Surveys of Science Resources Series.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

Detailed statistical tables on federal funds for research and development (R&D) are provided in this document. Tables are organized into the following sections: research, development, and R&D plant; R&D--agency, character of work, and performer; total research--agency, performer, and field of science; basic research--agency, performer,…

Using action research in nursing practice with older people: democratizing knowledge.

PubMed

Reed, Jan

2005-05-01

This paper reports on an action research study which raised some questions about the processes of developing a sense of shared ownership in action research in a research environment which does not always have the appropriate mechanisms to support and sustain action research. Action research has gained popularity in nursing and healthcare research, offering a way of developing practice-based knowledge, which can assist in changing practice and democratizing inquiry. There are other organizational constraints on action research which arise at different levels, and which also require discussion. These can be issues about communication and ownership at a practice level and issues of funding and project management procedures. This paper reports on a study in which these issues came to the fore, and offers some thoughts on how they can affect the processes of action research. While the principles of action research appear to offer much towards the development of a practice-rooted body of knowledge for nursing, unless some of the issues of ownership are resolved, it is unlikely to move beyond academic rhetoric. If nursing is to engage in action research, this must be done critically and reflectively and careful attention paid to developing an inclusive and collaborative approach to knowledge and practice development. Furthermore, to develop in nursing and health care research, it must find ways to meet the requirements of funding bodies.

Pre- and post-test evaluation of a project to facilitate research development in practice in a hospital setting.

PubMed

Clifford, C; Murray, S

2001-12-01

This paper describes a project designed to facilitate the use of research in nursing practice in one acute hospital. A university team worked in collaboration with staff from the hospital to develop and evaluate the impact of development work designed to enhance knowledge and use of research in practice. A research utilization questionnaire was administered as a pre-test (stage 1); a development phase was implemented (stage 2) and a post-test survey (stage 3) was administered to evaluate the impact of the development work. In stage 1, the total population of nursing and midwifery staff in the hospital (n=473) were targeted and 235 returned the questionnaire, giving a response rate of 50%. Data from the pre-test and focus group discussions with staff were used to plan stage 2 of the project. The development stage involved an educational strand in which open learning research materials were made available to staff, who were also offered tutorial support in their learning. A second strand supported the development of clinical research projects and funds were identified for clinical staff to apply for project development awards to enable them to develop skills in research and development activity under the supervision of a research fellow. Stage 3 involved a post-test survey of staff who had completed the questionnaire in stage 1 (n=81). There were no significant differences in findings between the pre-test and post-test. Qualitative data from those involved in the clinical projects in stage 2 indicated factors impacting on the feasibility of undertaking research in practice.

Community Economic Development: Perspectives on Research and Policy.

ERIC Educational Resources Information Center

Galaway, Burt, Ed.; Hudson, Joe, Ed.

This book contains 27 papers that were originally developed for a research and policy symposium at which Canadian community economic development (CED) was examined in terms of research and policy requirements. The book contains the following papers: "Community Economic Development Practice in Canada" (Brodhead); "Community Economic…

Tertiary Education in the Eighties: Paths to Reward and Growth. Research and Development in Higher Education, Volume 6.

ERIC Educational Resources Information Center

Moses, Ingrid, Ed.

Developments in college teaching, research, staff development in Australia during the 1980s are addressed in 38 papers from the 1983 conference of the Higher Education Research and Development Society of Australasia. Themes of the papers include: institutional change, staff perceptions of rewards, professional development, students and tertiary…

Managing the Public Sector Research and Development Portfolio Selection Process: A Case Study of Quantitative Selection and Optimization

DTIC Science & Technology

2016-09-01

PUBLIC SECTOR RESEARCH & DEVELOPMENT PORTFOLIO SELECTION PROCESS: A CASE STUDY OF QUANTITATIVE SELECTION AND OPTIMIZATION by Jason A. Schwartz...PUBLIC SECTOR RESEARCH & DEVELOPMENT PORTFOLIO SELECTION PROCESS: A CASE STUDY OF QUANTITATIVE SELECTION AND OPTIMIZATION 5. FUNDING NUMBERS 6...describing how public sector organizations can implement a research and development (R&D) portfolio optimization strategy to maximize the cost

Gender Development Research in Sex Roles: Historical Trends and Future Directions.

PubMed

Zosuls, Kristina M; Miller, Cindy Faith; Ruble, Diane N; Martin, Carol Lynn; Fabes, Richard A

2011-06-01

The late 1960s through the 1970s marked an important turning point in the field of gender research, including theory and research in gender development. The establishment of Sex Roles in 1975 as a forum for this research represented an important milestone in the field. In this article, we celebrate the 35th anniversary of Sex Roles and, in particular, its contributions to the field of research on children's and adolescents' gender development. We examine the trends in research on gender development published in Sex Roles since its inception and use this analysis as a vehicle for exploring how the field has grown and evolved over the past few decades. We begin with a brief review of the history of this field of research since 1975. Then, we present a descriptive assessment of articles published on gender development in Sex Roles over time, and link this assessment to general trends that have occurred in the study of gender development over the past 35 years. We conclude with a discussion of future directions for the field of gender development. In particular, we highlight areas in which the journal could play a role in promoting more diversity in topics, methods, and ages employed in gender development research.

Gender Development Research in Sex Roles: Historical Trends and Future Directions

PubMed Central

Miller, Cindy Faith; Ruble, Diane N.; Martin, Carol Lynn; Fabes, Richard A.

2011-01-01

The late 1960s through the 1970s marked an important turning point in the field of gender research, including theory and research in gender development. The establishment of Sex Roles in 1975 as a forum for this research represented an important milestone in the field. In this article, we celebrate the 35th anniversary of Sex Roles and, in particular, its contributions to the field of research on children’s and adolescents’ gender development. We examine the trends in research on gender development published in Sex Roles since its inception and use this analysis as a vehicle for exploring how the field has grown and evolved over the past few decades. We begin with a brief review of the history of this field of research since 1975. Then, we present a descriptive assessment of articles published on gender development in Sex Roles over time, and link this assessment to general trends that have occurred in the study of gender development over the past 35 years. We conclude with a discussion of future directions for the field of gender development. In particular, we highlight areas in which the journal could play a role in promoting more diversity in topics, methods, and ages employed in gender development research. PMID:21747580

Outlook on Research in Education for Sustainable Development

ERIC Educational Resources Information Center

Grasel, Cornelia; Bormann, Inka; Schutte, Kerstin; Trempler, Kati; Fischbach, Robert

2013-01-01

This article provides an overview of current research on Education for Sustainable Development (ESD). It shows a lack of correspondence between ESD research and recent debates in educational research. Research on ESD has established as a field of research with insufficient relations to other fields in educational research. Based on the overview…

Rejecting, revitalizing, and reclaiming: First Nations work to set the direction of research and policy development.

PubMed

Ten Fingers, Keely

2005-01-01

The history and legacy of Western, colonial research methodologies and policy frameworks continue to create and maintain dichotomies of superior/inferior, and valued/not valued between Western and First Nations cultures, peoples and knowledge. This article was written to awaken discussion on how First Nations are working to shape the direction of research and policy development. It draws upon the author's personal observations and experiences of Western and Indigenous frameworks. The author also draws upon the growing body of work on this issue presented by indigenous researchers and scholars. The Health Information Research Committee of the Assembly of Manitoba Chiefs rejects colonial research frameworks and promotes and supports culturally-respectful research. The Dakota in Manitoba are identifying our own Quality of Life indicators and developing policies based on our own cultural values. The Mohawk of Akwesasne have developed research ethics and protocols based on their cultural principles of skennen (peace), kariwiio (good word), and kasastensera (strength). First Nations people in Canada and the world are increasingly rejecting Western, colonial frameworks of research and policy development. Instead, we are reclaiming our right to be who we are, and we are revitalizing our cultures through promotion and utilization of indigenous research methodologies and development of culturally-rooted policy. Though the response of researchers and policy-makers is not yet known, these developments will continue into the future due to the commitment and work of First Nations people.

Stem cell research in pakistan; past, present and future.

PubMed

Zahra, Sayeda Anum; Muzavir, Sayed Raheel; Ashraf, Sadia; Ahmad, Aftab

2015-05-01

Stem cells have proved to have great therapeutic potential as stem cell treatment is replacing traditional ways of treatment in different disorders like cancer, aplastic anemia, stroke, heart disorders. The developed and developing countries are investing differently in this area of research so research output and clinical translation of research greatly vary among developed and developing countries. Present study was done to investigate the current status of stem cells research in Pakistan and ways to improve it. Many advanced countries (USA, UK and Canada etc.) are investing heavily in stem cell research and treatment. Different developing countries like Iran, Turkey and India are also following the developed countries and investing a lot in stem cells research. Pakistan is also making efforts in establishing this field to get desired benefits but unfortunately the progress is at very low pace. If Government plays an active role along with private sector, stem cell research in Pakistan can be boosted up. The numbers of publications from Pakistan are very less compared to developed and neighboring countries and Pakistan also has very less number of institutes working in this area of research. Stem cells research is at its initial stages in Pakistan and there is great need to bring Government, academia and industry together so they could make serious efforts to promote research in this very important field. This will help millions of patients suffering from incurable disorders and will also reduce economic loss.

Parameter estimation in Probabilistic Seismic Hazard Analysis: current problems and some solutions

NASA Astrophysics Data System (ADS)

Vermeulen, Petrus

2017-04-01

A typical Probabilistic Seismic Hazard Analysis (PSHA) comprises identification of seismic source zones, determination of hazard parameters for these zones, selection of an appropriate ground motion prediction equation (GMPE), and integration over probabilities according the Cornell-McGuire procedure. Determination of hazard parameters often does not receive the attention it deserves, and, therefore, problems therein are often overlooked. Here, many of these problems are identified, and some of them addressed. The parameters that need to be identified are those associated with the frequency-magnitude law, those associated with earthquake recurrence law in time, and the parameters controlling the GMPE. This study is concerned with the frequency-magnitude law and temporal distribution of earthquakes, and not with GMPEs. TheGutenberg-Richter frequency-magnitude law is usually adopted for the frequency-magnitude law, and a Poisson process for earthquake recurrence in time. Accordingly, the parameters that need to be determined are the slope parameter of the Gutenberg-Richter frequency-magnitude law, i.e. the b-value, the maximum value at which the Gutenberg-Richter law applies mmax, and the mean recurrence frequency,λ, of earthquakes. If, instead of the Cornell-McGuire, the "Parametric-Historic procedure" is used, these parameters do not have to be known before the PSHA computations, they are estimated directly during the PSHA computation. The resulting relation for the frequency of ground motion vibration parameters has an analogous functional form to the frequency-magnitude law, which is described by parameters γ (analogous to the b¬-value of the Gutenberg-Richter law) and the maximum possible ground motion amax (analogous to mmax). Originally, the approach was possible to apply only to the simple GMPE, however, recently a method was extended to incorporate more complex forms of GMPE's. With regards to the parameter mmax, there are numerous methods of estimation, none of which is accepted as the standard one. There is also much controversy surrounding this parameter. In practice, when estimating the above mentioned parameters from seismic catalogue, the magnitude, mmin, from which a seismic catalogue is complete becomes important.Thus, the parameter mmin is also considered as a parameter to be estimated in practice. Several methods are discussed in the literature, and no specific method is preferred. Methods usually aim at identifying the point where a frequency-magnitude plot starts to deviate from linearity due to data loss. Parameter estimation is clearly a rich field which deserves much attention and, possibly standardization, of methods. These methods should be the sound and efficient, and a query into which methods are to be used - and for that matter which ones are not to be used - is in order.

GPP/RE Partitioning of Long-term Network Flux Data as a Tool for Estimating Ecosystem-scale Ecophysiological Parameters of Grasslands and Croplands

NASA Astrophysics Data System (ADS)

Gilmanov, T. G.; Wylie, B. K.; Gu, Y.; Howard, D. M.; Zhang, L.

2013-12-01

The physiologically based model of canopy CO2 exchange by Thornly and Johnson (2000) modified to incorporate vapor pressure deficit (VPD) limitation of photosynthesis is a robust tool for partitioning tower network net CO2 exchange data into gross photosynthesis (GPP) and ecosystem respiration (RE) (Gilmanov et al. 2013a, b). In addition to 30-min and daily photosynthesis and respiration values, the procedure generates daily estimates and uncertainties of essential ecosystem-scale parameters such as apparent quantum yield ALPHA, photosynthetic capacity AMAX, convexity of light response THETA, gross ecological light-use efficiency LUE, daytime ecosystem respiration rate RDAY, and nighttime ecosystem respiration rate RNIGHT. These ecosystem-scale parameters are highly demanded by the modeling community and open opportunities for comparison with the rich data of leaf-level estimates of corresponding parameters available from physiological studies of previous decades. Based on the data for 70+ site-years of flux tower measurements at the non-forest sites of the Ameriflux network and the non-affiliated sites, we present results of the comparative analysis and multi-site synthesis of the magnitudes, uncertainties, patterns of seasonal and yearly dynamics, and spatiotemporal distribution of these parameters for grasslands and croplands of the conterminous United States (CONUS). Combining this site-level parameter data set with the rich spatiotemporal data sets of a remotely sensed vegetation index, weather and climate conditions, and site biophysical and geophysical features (phenology, photosynthetically active radiation, and soil water holding capacity) using methods of multivariate analysis (e.g., Cubist regression tree) offers new opportunities for predictive modeling and scaling-up of ecosystem-scale parameters of carbon cycling in grassland and agricultural ecosystems of CONUS (Zhang et al. 2011; Gu et al. 2012). REFERENCES Gilmanov TG, Baker JM, Bernacchi CJ, Billesbach DP, Burba GG, et al. (2013a). Productivity and CO2 exchange of the leguminous crops: Estimates from flux tower measurements. Agronomy J (submitted). Gilmanov TG, Wylie BK, Tieszen LL, Meyers TP, Baron VS, et al. (2013b). CO2 uptake and ecophysiological parameters of the grain crops of midcontinent North America: Estimates from flux tower measurements. Agric Ecosyst Environm 164: 162-175 Gu Y, Howard DM, Wylie BK, and Zhang L (2012). Mapping carbon flux uncertainty and selecting optimal locations for future flux towers in the Great Plains: Landscape Ecology, 27: 319-326. Thornley JHM., Johnson IR (2000). Plant and crop modelling. A mathematical approach to plant and crop physiology. The Blackburn Press, Caldwell, New Jersey. Zhang L, Wylie BK, Ji L, Gilmanov TG, Tieszen LL, Howard DM (2011). Upscaling carbon fluxes over the Great Plains grasslands: Sinks and sources. J Geophys Res G: Biogeosciences 116: G00J3

Inhaled nebulised unfractionated heparin improves lung function in moderate to very severe COPD: A pilot study.

PubMed

Shute, Janis K; Calzetta, Luigino; Cardaci, Vittorio; di Toro, Stefania; Page, Clive P; Cazzola, Mario

2018-02-01

COPD is an inflammatory airway disease characterised by progressive airflow limitation and air trapping, leading to lung hyperinflation and exercise limitation. Acute worsening of symptoms, including dyspnea, cough and sputum production, occurs during exacerbations which are associated with significantly reduced health related quality of life, and increased morbidity and mortality. Chronic bronchial mucus production and productive cough are risk factors for exacerbations. Medicines targeting bronchoconstriction and airway inflammation are the current mainstays of COPD therapy. However, there is growing concern with an increased risk of pneumonia in patients with COPD receiving regular inhaled corticosteroids and there is therefore a need to find safer alternative treatments. Previous studies have indicated that inhalation of unfractionated heparin (UFH) treats local inflammation, mucus hypersecretion and lung injury, without systemic anticoagulation, and is safe. Therefore, our primary objective was to demonstrate that inhaled UFH significantly improves lung function (FEV 1 ) over 21 days of treatment in patients with COPD receiving pulmonary rehabilitation and that UFH provides a novel, safe and effective way of treating this complex disease. Forty patients with moderate to very severe COPD admitted to the IRCCS San Raffaele Pisana Hospital for 21 days pulmonary rehabilitation were randomised to receive nebulised inhaled UFH (75,000 or 150,000 IU BID) or placebo for 21 days. All patients also received nebulised salbutamol (1 mg) and beclomethasone dipropionate (400 μg) BID over the same period. Lung function was measured at day 0, 7, 14 and 21 of treatment and at a follow-up visit 7 days post-treatment. Exercise capacity (6MWT) and dyspnoea (Borg score) were measured before and after treatment. In pre-clinical studies, the ability of basic proteins found in COPD sputum to neutralise the anticoagulant activity of heparin was determined using the AMAX heparin assay kit. At both doses, UFH significantly increased FVC following 7 days of treatment and 150,000 IU BID significantly increased FEV1 (+249 ± 69 ml compared with placebo) at this time, an effect maintained to the 28 day follow-up. Clinically significant improvement in exercise capacity and dyspnoea were seen after 21 days of treatment with both doses of UFH. There were no serious adverse events or effects on systemic coagulation. Pre-clinical studies demonstrated that the basic proteins lactoferrin, platelet factor-4 (PF-4), IL-8 and polyarginine, as a model of the eosinophil cationic protein (ECP), found in COPD sputum neutralise the anticoagulant activity of heparin. Inhaled nebulised UFH is safe and provides additional clinical benefit for patients with moderate to very severe COPD through effects that are independent of its anticoagulant activity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Education review: a computer-assisted instructional tool to assist students in developing an epidemiological research proposal.

PubMed

Watzlaf, V J; Addeo, L; Nous, A

1995-11-01

The development of an epidemiological research proposal can be a difficult assignment for junior health information management students. The article demonstrates how a computer-assisted instructional (CAI) tool was developed to assist students in the development of an epidemiological research proposal. Surveys were conducted to determine where students were having the most problems, information about writing a research proposal was gathered and organized into an appropriate format, appropriate software (Hypercard) was chosen, the final CAI tool (the Research and Grant Writer) was developed, and positive feedback was obtained from junior health information management students using the CAI tool.

The Development of Research Skills in Young Adults with Intellectual Disability in Participatory Research

ERIC Educational Resources Information Center

Morgan, Michelle F.; Moni, Karen B.; Cuskelly, Monica

2015-01-01

There is limited information about specific research constructs developed by adults with intellectual disability in undertaking research despite increasing involvement in research "with" rather than "on" these individuals. Participatory research was used with three young adults with intellectual disability to collaboratively…

48 CFR 3452.224-71 - Notice about research activities involving human subjects.

Code of Federal Regulations, 2012 CFR

2012-10-01

... research as “a systematic investigation, including research development, testing and evaluation, designed... deliberate plan designed to develop or contribute to generalizable knowledge, it is research. Research... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Notice about research...

48 CFR 3452.224-71 - Notice about research activities involving human subjects.

Code of Federal Regulations, 2011 CFR

2011-10-01

... research as “a systematic investigation, including research development, testing and evaluation, designed... deliberate plan designed to develop or contribute to generalizable knowledge, it is research. Research... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Notice about research...

48 CFR 3452.224-71 - Notice about research activities involving human subjects.

Code of Federal Regulations, 2013 CFR

2013-10-01

... research as “a systematic investigation, including research development, testing and evaluation, designed... deliberate plan designed to develop or contribute to generalizable knowledge, it is research. Research... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Notice about research...

48 CFR 3452.224-71 - Notice about research activities involving human subjects.

Code of Federal Regulations, 2014 CFR

2014-10-01

... research as “a systematic investigation, including research development, testing and evaluation, designed... deliberate plan designed to develop or contribute to generalizable knowledge, it is research. Research... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Notice about research...

75 FR 65404 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... & Regenerative Medicine Subcommittee of the Rehabilitation Research and Development Service Scientific Merit..., examination, reference to, [[Page 65405

Developing a spinal cord injury research strategy using a structured process of evidence review and stakeholder dialogue. Part III: outcomes.

PubMed

Middleton, J W; Piccenna, L; Lindsay Gruen, R; Williams, S; Creasey, G; Dunlop, S; Brown, D; Batchelor, P E; Berlowitz, D J; Coates, S; Dunn, J A; Furness, J B; Galea, M P; Geraghty, T; Kwon, B K; Urquhart, S; Yates, D; Bragge, P

2015-10-01

Focus Group. To develop a unified, regional spinal cord injury (SCI) research strategy for Australia and New Zealand. Australia. A 1-day structured stakeholder dialogue was convened in 2013 in Melbourne, Australia, by the National Trauma Research Institute in collaboration with the SCI Network of Australia and New Zealand. Twenty-three experts participated, representing local and international research, clinical, consumer, advocacy, government policy and funding perspectives. Preparatory work synthesised evidence and articulated draft principles and options as a starting point for discussion. A regional SCI research strategy was proposed, whose objectives can be summarised under four themes. (1) Collaborative networks and strategic partnerships to increase efficiency, reduce duplication, build capacity and optimise research funding. (2) Research priority setting and coordination to manage competing studies. (3) Mechanisms for greater consumer engagement in research. (4) Resources and infrastructure to further develop SCI data registries, evaluate research translation and assess alignment of research strategy with stakeholder interests. These are consistent with contemporary international SCI research strategy development activities. This first step in a regional SCI research strategy has articulated objectives for further development by the wider SCI research community. The initiative has also reinforced the importance of coordinated, collective action in optimising outcomes following SCI.

Professional Development for E-Learning: Researching a Strategy for New Zealand's Tertiary Education Sector

ERIC Educational Resources Information Center

Shephard, Kerry; Mansvelt, Juliana; Stein, Sarah; Suddaby, Gordon; Harris, Irene; O'Hara, Duncan

2011-01-01

This collaborative research project devised a framework to support professional development for e-learning within New Zealand's diverse and integrated tertiary education sector. The research was supported by New Zealand's Ministry of Education. The research included reviews of developments in the United Kingdom, Australia and New Zealand and a…

32 CFR 22.310 - Statutes concerning certain research, development, and facilities construction grants.

Code of Federal Regulations, 2012 CFR

2012-07-01

... higher education for the performance of research and development or for the construction of research or... institutions of higher education by other than merit-based competitive procedures. (c) Subsequent statutes. In..., unless: (1) Institutions of higher education—new grants for research and development. In the case of a...

32 CFR 22.310 - Statutes concerning certain research, development, and facilities construction grants.

Code of Federal Regulations, 2014 CFR

2014-07-01

... higher education for the performance of research and development or for the construction of research or... institutions of higher education by other than merit-based competitive procedures. (c) Subsequent statutes. In..., unless: (1) Institutions of higher education—new grants for research and development. In the case of a...

32 CFR 22.310 - Statutes concerning certain research, development, and facilities construction grants.

Code of Federal Regulations, 2013 CFR

2013-07-01

... higher education for the performance of research and development or for the construction of research or... institutions of higher education by other than merit-based competitive procedures. (c) Subsequent statutes. In..., unless: (1) Institutions of higher education—new grants for research and development. In the case of a...

Pre-Service Teachers Undertaking Classroom Research: Developing Reflection and Enquiry Skills

ERIC Educational Resources Information Center

Medwell, Jane; Wray, David

2014-01-01

This paper reports on the development of reflectiveness and research skills in eight pre-service teachers, through their participation in a funded research project to develop the handwriting of children with literacy problems. The project aimed to analyse the reflections of the trainee teachers participating in an authentic research study and to…

Review of Physics Research Programs at LAMPF. Progress report, January-December 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allred, J.C.

1984-04-01

Research and development summaries are presented under the main headings: research, proton storage ring construction and research program development, status of LAMPF II, facility and experimental development, and accelerator operations. Complete lists are given for experiments run in 1983, new prospects, and active and complete experiments by channel. (WHK)

17 CFR 270.3a-8 - Certain research and development companies.

Code of Federal Regulations, 2013 CFR

2013-04-01

... and development costs as defined in FASB ASC Topic 730, Research and Development, as currently in... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Certain research and... COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.3a-8 Certain research and...

17 CFR 270.3a-8 - Certain research and development companies.

Code of Federal Regulations, 2014 CFR

2014-04-01

... and development costs as defined in FASB ASC Topic 730, Research and Development, as currently in... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Certain research and... COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.3a-8 Certain research and...

17 CFR 270.3a-8 - Certain research and development companies.

Code of Federal Regulations, 2012 CFR

2012-04-01

... and development costs as defined in FASB ASC Topic 730, Research and Development, as currently in... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Certain research and... COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.3a-8 Certain research and...

Educational Research and Development in the United States.

ERIC Educational Resources Information Center

Organisation for Economic Cooperation and Development, Paris (France).

This volume explores the development, present status, and future growth of educational research and development in the United States and documents U.S. educational research efforts as a guide for OECD member nations. Topics include (1) the organization of and issues in education in the United States, (2) the history of educational research, (3)…

48 CFR 227.7107-2 - Contracts for construction supplies and research and development work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... supplies and research and development work. 227.7107-2 Section 227.7107-2 Federal Acquisition Regulations... research and development work. Use the provisions and clauses required by 227-7103-6 and 227.7203-6 when..., or research work, or test and evaluation studies of structures, equipment, processes, or materials...

48 CFR 1852.235-74 - Additional Reports of Work-Research and Development.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-Research and Development. 1852.235-74 Section 1852.235-74 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.235-74 Additional Reports of Work—Research and Development. As prescribed in 1835.070(e), insert a clause substantially the same as the following: Additional Reports of Work—Research...

48 CFR 1852.235-74 - Additional Reports of Work-Research and Development.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-Research and Development. 1852.235-74 Section 1852.235-74 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.235-74 Additional Reports of Work—Research and Development. As prescribed in 1835.070(e), insert a clause substantially the same as the following: Additional Reports of Work—Research...

48 CFR 1852.235-74 - Additional Reports of Work-Research and Development.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-Research and Development. 1852.235-74 Section 1852.235-74 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.235-74 Additional Reports of Work—Research and Development. As prescribed in 1835.070(e), insert a clause substantially the same as the following: Additional Reports of Work—Research...

48 CFR 1852.235-74 - Additional Reports of Work-Research and Development.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-Research and Development. 1852.235-74 Section 1852.235-74 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.235-74 Additional Reports of Work—Research and Development. As prescribed in 1835.070(e), insert a clause substantially the same as the following: Additional Reports of Work—Research...

48 CFR 1852.235-74 - Additional Reports of Work-Research and Development.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-Research and Development. 1852.235-74 Section 1852.235-74 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.235-74 Additional Reports of Work—Research and Development. As prescribed in 1835.070(e), insert a clause substantially the same as the following: Additional Reports of Work—Research...

A Research Agenda for the National Institute of Education.

ERIC Educational Resources Information Center

Hodgkinson, Harold L.

This speech outlines issues that the author thinks would have to be considered in building a research and development agenda concerned with the relationship of education to work. Background about U.S. investment in educational research and development is given and budgetary expenditures in the educational research and development field are…

48 CFR 52.246-9 - Inspection of Research and Development (Short Form).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Clauses 52.246-9 Inspection of Research and Development (Short Form). As prescribed in 46.309, insert the following clause: Inspection of Research and Development (Short Form) (APR 1984) The Government has the... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Inspection of Research and...

Improving the quality of healthcare for children: implementing the results of the AHSR research agenda conference.

PubMed Central

Halfon, N; Schuster, M; Valentine, W; McGlynn, E

1998-01-01

OBJECTIVE: To describe the rationale, development, content, and results of the AHSR-sponsored conference on developing a research agenda focused on improving the quality of care for children. DATA SOURCES AND METHODS: Planning documents, background papers, and conference proceedings. PRINCIPAL FINDINGS: The conference developed the research agenda focused on (1) monitoring the health of children; (2) evaluating the efficacy and effectiveness of health services for children; (3) assessing the quality of healthcare provided to children; (4) improving the quality of healthcare within health systems; (5) assessing the performance of community systems for children; (6) exploring the impact of different financial incentives on the provision of pediatric healthcare; and (7) developing and disseminating clinical practice guidelines and other information to physicians, families, and consumers. Specific issues and research questions in each area are also presented. Strategies for implementing the research agenda are presented and include: (1) expanding the child health services research workforce; (2) developing child healthcare quality improvement research centers; (3) conducting research in specific high-priority areas; (4) focusing research on improving the health of vulnerable populations; (5) improving child health data and collection systems at the national level; (6) developing better community health monitoring for children; (7) building and supporting research networks and a consortium of research users; and (8) developing a coordinated interagency federal effort to advance this agenda and to provide accountability for its completion. CONCLUSION: The proposed research agenda should be a national priority so that all Americans can be assured that children are receiving the best quality of care that the United States can provide. PMID:9776945

Basic and applied research program. Semiannual report, July-December 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butler, B.L.

1979-12-01

The status of research projects in the Basic and Applied Research Program at SERI is presented for the semiannual period ending December 31, 1978. The five tasks in this program are grouped into Materials Research and Development, Materials Processing and Development, Photoconversion Research, Exploratory Research, and Energy Resource and Assessment and have been carried out by personnel in the Materials, Bio/Chemical Conversion, and Energy Resource and Assessment Branches. Subtask elements in the task areas include coatings and films, polymers, metallurgy and corrosion, optical materials, surfaces and interfaces in materials research and development; photochemistry, photoelectrochemistry, and photobiology in photoconversion; thin glassmore » mirror development, silver degradation of mirrors, hail resistance of thin glass, thin glass manufacturing, cellular glass development, and sorption by desiccants in materials processing and development; and thermoelectric energy conversion, desiccant cooling, photothermal degradation, and amorphous materials in exploratory research. For each task or subtask element, the overview, scope, goals, approach, apparatus and equipment, and supporting subcontracts are presented, as applicable, in addition to the status of the projects in each task or subtask. Listing of publications and reports authored by personnel associated with the Basic and Applied Research Program and prepared or published during 1978 are also included.« less

[Does the public sector have an independent research role in the development of drugs?].

PubMed

Poulsen, Henrik Enghusen; Grønlykke, Thor Buch

2003-04-14

Exclusively private companies do drug development. The State contributes with education of academics and basic research constituting the basis of half of the drugs developed by the private companies. The Danish private drug research amounts to six billion DKK per year, corresponding to the estimated price of the development of one new drug. The development shows a negative tendency. There are doubts about the scientific credibility, the number of new drugs is declining, drug development costs are rising, and the competitiveness in Europe is declining compared with the one of The United States. Continued improvement of Danish drug development can be achieved by stimulation of the public research related to drug development.

Research-Based Learning: Teaching Development through Fieldschools

ERIC Educational Resources Information Center

Guinness, Patrick

2012-01-01

The challenge of bringing research-based learning to undergraduate development studies and anthropology students has led to convening a fieldschool in Indonesia. The fieldschool has been vital in introducing students to fieldwork methodology and in developing a deeper understanding of the relation of research data to development theory. In…

Development Research of a Teachers' Educational Performance Support System: The Practices of Design, Development, and Evaluation

ERIC Educational Resources Information Center

Hung, Wei-Chen; Smith, Thomas J.; Harris, Marian S.; Lockard, James

2010-01-01

This study adopted design and development research methodology (Richey & Klein, "Design and development research: Methods, strategies, and issues," 2007) to systematically investigate the process of applying instructional design principles, human-computer interaction, and software engineering to a performance support system (PSS) for behavior…

Vocational Training and Placement of the Severely Handicapped: Research and Development Recommendations.

ERIC Educational Resources Information Center

Cook, Paul F.; Dahl, Peter R.

The monograph synthesizes findings of the Vocational Training and Placement of the Severely Handicapped Project (VOTAP) and offers recommendations for further research and development. Chapter 1 presents the theoretical model that describes the dimensions upon which the task of developing research and development recommendations could be…

Pointer Animation Implementation at Development of Multimedia Learning of Java Programming

ERIC Educational Resources Information Center

Rusli, Muhammad; Atmojo, Yohanes Priyo

2015-01-01

This research represents the development research using the references of previous research results related to the development of interactive multimedia learning (learner controlled), specially about the effectiveness and efficiency of multimedia learning of a content that developed by pointer animation implementation showing the content in…

Accomplishing and applying National Fire Plan research and development from 2001-2005

Treesearch

Baldwin V. Jr. Clark

2007-01-01

This report highlights selected accomplishments achieved by USDA Forest Service National Fire Plan Research and Development projects from 2001 through 2006. The projects highlighted here are examples of the broad range of knowledge and tools developed by the National Fire Plan Research and Development, beginning in 2001.

Understanding the Conceptual Development Phase of Applied Theory-Building Research: A Grounded Approach

ERIC Educational Resources Information Center

Storberg-Walker, Julia

2007-01-01

This article presents a provisional grounded theory of conceptual development for applied theory-building research. The theory described here extends the understanding of the components of conceptual development and provides generalized relations among the components. The conceptual development phase of theory-building research has been widely…

77 FR 31072 - Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative... Development Officer through the Director of the Clinical Science Research and Development Service on the... notice under Public Law 92-463 (Federal Advisory Committee Act) that a meeting of the Clinical Science...

7 CFR 982.58 - Research, promotion, and market development.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Research, promotion, and market development. 982.58... GROWN IN OREGON AND WASHINGTON Order Regulating Handling Market Development § 982.58 Research, promotion, and market development. (a) General. The Board, with the approval of the Secretary, may establish or...

Facilitating factors and barriers to malaria research utilization for policy development in Malawi.

PubMed

Mwendera, Chikondi A; de Jager, Christiaan; Longwe, Herbert; Phiri, Kamija; Hongoro, Charles; Mutero, Clifford M

2016-10-19

Research on various determinants of health is key in providing evidence for policy development, thereby leading to successful interventions. Utilization of research is an intricate process requiring an understanding of contextual factors. The study was conducted to assess enhancing factors and barriers of research utilization for malaria policy development in Malawi. Qualitative research approach was used through in-depth interviews with 39 key informants that included malaria researchers, policy makers, programme managers, and key stakeholders. Purposive sampling and snowballing techniques were used in identifying key informants. Interview transcripts were entered in QSR Nvivo 11 software for coding and analysis. Respondents identified global efforts as key in advancing knowledge translation, while local political will has been conducive for research utilization. Other factors were availability of research, availability of diverse local researchers and stakeholders supporting knowledge translation. While barriers included: lack of platforms for researcher-public engagement, politics, researchers' lack of communication skills, lack of research collaborations, funder driven research, unknown World Health Organization policy position, and the lack of a malaria research repository. Overall, the study identified facilitating factors to malaria research utilization for policy development in Malawi. These factors need to be systematically coordinated to address the identified barriers and improve on malaria research utilization in policy development. Malaria research can be key in the implementation of evidence-based interventions to reduce the malaria burden and assist in the paradigm shift from malaria control to elimination in Malawi.

Different Types of Action Research to Promote Chemistry Teachers' Professional Development--A Joined Theoretical Reflection on Two Cases from Israel and Germany

ERIC Educational Resources Information Center

Mamlok-Naaman, Rachel; Eilks, Ingo

2012-01-01

Action research is defined as using research activities to develop concrete societal practices. Action research understands the change of practice as being already a central aim of the research process itself, and it also seeks to contribute to the professional development of all participants in the particular field of study. Even though (or maybe…

Researching "Race," Racism and Antiracism: The Development of an Ethical Code.

ERIC Educational Resources Information Center

Netto, Gina; Diniz, Fernando Almeida

2001-01-01

Black researchers collaborated to establish the Scottish Association of Black Researchers (SABRE) and developed "An Ethical Code for Researching Race, Racism and Anti-Racism in Scotland." Highlights the neglect of this issue by mainstream research, the importance of research on race in Scotland, and fundamental questions about the…

Changing Research Practices and Research Infrastructure Development

ERIC Educational Resources Information Center

Houghton, John W.

2005-01-01

This paper examines changing research practices in the digital environment and draws out implications for the development of research infrastructure. Reviews of the literature, quantitative indicators of research activities and our own field research in Australia suggest that there is a new mode of knowledge production emerging, changing research…

Building an Australasian paramedicine research agenda: a narrative review.

PubMed

O'Meara, Peter; Maguire, Brian; Jennings, Paul; Simpson, Paul

2015-12-15

The need for paramedicine research has been recognised internationally through efforts to develop out-of-hospital research agendas in several developed countries. Australasia has a substantial paramedicine research capacity compared to the discipline internationally and is well positioned as a potential leader in the drive towards evidence-based policy and practice in paramedicine. Our objective was to draw on international experiences to identify and recommend the best methodological approach that should be employed to develop an Australasian paramedicine research agenda. A search and critical appraisal process was employed to produce an overview of the literature related to the development of paramedicine research agendas throughout the world. Based on these international experiences, and our own analysis of the Australasian context, we recommend that a mixed methods approach be used to develop an inclusive Australasian Paramedicine Research Agenda. This approach will capture the views and interests of a wide range of expert stakeholders through multiple data collection strategies, including interviews, roundtable discussions and an online Delphi consensus survey. Paramedic researchers and industry leaders have the opportunity to use this multidisciplinary process of inquiry to develop a paramedicine research agenda that will provide a framework for the development of a culture of open evaluation, innovation and improvement. This research agenda would assess the progress of paramedicine research in Australia and New Zealand, map the research capacity of the paramedicine discipline, paramedic services, universities and professional organisations, identify current strengths and opportunities, make recommendations to capitalize on opportunities, and identify research priorities. Success will depend on ensuring the participation of a representative sample of expert stakeholders, fostering an open and collaborative roundtable discussion, and adhering to a predefined approach to measure consensus on each topic.

Designing Summer Research Experiences for Teachers and Students That Promote Classroom Science Inquiry Projects and Produce Research Results

NASA Astrophysics Data System (ADS)

George, L. A.; Parra, J.; Rao, M.; Offerman, L.

2007-12-01

Research experiences for science teachers are an important mechanism for increasing classroom teachers' science content knowledge and facility with "real world" research processes. We have developed and implemented a summer scientific research and education workshop model for high school teachers and students which promotes classroom science inquiry projects and produces important research results supporting our overarching scientific agenda. The summer training includes development of a scientific research framework, design and implementation of preliminary studies, extensive field research and training in and access to instruments, measurement techniques and statistical tools. The development and writing of scientific papers is used to reinforce the scientific research process. Using these skills, participants collaborate with scientists to produce research quality data and analysis. Following the summer experience, teachers report increased incorporation of research inquiry in their classrooms and student participation in science fair projects. This workshop format was developed for an NSF Biocomplexity Research program focused on the interaction of urban climates, air quality and human response and can be easily adapted for other scientific research projects.

Research and Development in Teacher Education in Asia. Final Report of the Working Group Meeting on Research and Development in Teacher Education (Baguio City Philippines, January 11-20, 1972).

ERIC Educational Resources Information Center

Philippines Univ., Quezon City. Asian Inst. for Teacher Educators.

This UNESCO-sponsored report contains innovations and program recommendations for a research-development approach to teacher education in Asia. The first section of the report deals with the problems of an educational lag in Asia, with emphasis on educational research and development in teacher education as a solution to these problems. The second…

Evaluating the benefits of government funded R & D aimed at the private sector

NASA Technical Reports Server (NTRS)

Greenberg, J. S.

1977-01-01

Federal funding of technological research and development is discussed with regard to the procedures for an economic analysis with the goals of (1) determining when the public sector should invest in a research and development program, (2) evaluating the likelihood of private sector participation in terms of public sector participation, and (3) considering the major factors in the formulation of a research and development program in terms of defining initiatives. Public sector investments are evaluated, noting procedures for determining whether benefits exceed costs. The role of the public sector research and development planning is described, considering the procedure for private sector implementation decisions and a methodology for evaluating the possibility of private sector commercialization. The economic value of the public sector research and development program is presented with attention given to a specific case of NASA-sponsored research and development aimed toward the commercialization of new public communications services.

Using Qualitative Research to Inform Development of Professional Guidelines: A Case Study of the Society of Critical Care Medicine Family-Centered Care Guidelines.

PubMed

Coombs, Maureen A; Davidson, Judy E; Nunnally, Mark E; Wickline, Mary A; Curtis, J Randall

2017-08-01

To explore the importance, challenges, and opportunities using qualitative research to enhance development of clinical practice guidelines, using recent guidelines for family-centered care in the ICU as an example. In developing the Society of Critical Care Medicine guidelines for family-centered care in the neonatal ICU, PICU, and adult ICU, we developed an innovative adaptation of the Grading of Recommendations, Assessments, Development and Evaluations approach to explicitly incorporate qualitative research. Using Grading of Recommendations, Assessments, Development and Evaluations and the Council of Medical Specialty Societies principles, we conducted a systematic review of qualitative research to establish family-centered domains and outcomes. Thematic analyses were undertaken on study findings and used to support Population, Intervention, Comparison, Outcome question development. We identified and employed three approaches using qualitative research in these guidelines. First, previously published qualitative research was used to identify important domains for the Population, Intervention, Comparison, Outcome questions. Second, this qualitative research was used to identify and prioritize key outcomes to be evaluated. Finally, we used qualitative methods, member checking with patients and families, to validate the process and outcome of the guideline development. In this, a novel report, we provide direction for standardizing the use of qualitative evidence in future guidelines. Recommendations are made to incorporate qualitative literature review and appraisal, include qualitative methodologists in guideline taskforce teams, and develop training for evaluation of qualitative research into guideline development procedures. Effective methods of involving patients and families as members of guideline development represent opportunities for future work.

Advancing Aeronautics: A Decision Framework for Selecting Research Agendas

NASA Technical Reports Server (NTRS)

Anton, Philip S.; Ecola, Liisa; Kallimani, James G.; Light, Thomas; Ohlandt, Chad J. R.; Osburg, Jan; Raman, Raj; Grammich, Clifford A.

2011-01-01

Publicly funded research has long played a role in the development of aeronautics, ranging from foundational research on airfoils to development of the air-traffic control system. Yet more than a century after the research and development of successful controlled, sustained, heavier-than-air flight vehicles, there are questions over the future of aeronautics research. The field of aeronautics is relatively mature, technological developments within it have become more evolutionary, and funding decisions are sometimes motivated by the continued pursuit of these evolutionary research tracks rather than by larger factors. These developments raise questions over whether public funding of aeronautics research continues to be appropriate or necessary and at what levels. Tightened federal budgets and increasing calls to address other public demands make these questions sharper still. To help it address the questions of appropriate directions for publicly funded aeronautics research, the National Aeronautics and Space Administration's (NASA's) Aeronautics Research Mission Directorate (ARMD) asked the RAND Corporation to assess the elements required to develop a strategic view of aeronautics research opportunities; identify candidate aeronautic grand challenges, paradigms, and concepts; outline a framework for evaluating them; and exercise the framework as an example of how to use it. Accordingly, this research seeks to address these questions: What aeronautics research should be supported by the U.S. government? What compelling and desirable benefits drive government-supported research? How should the government--especially NASA--make decisions about which research to support? Advancing aeronautics involves broad policy and decisionmaking challenges. Decisions involve tradeoffs among competing perspectives, uncertainties, and informed judgment.

Evaluation of advanced R and D topics in photovoltaics

NASA Technical Reports Server (NTRS)

Surek, T.

1982-01-01

An evaluation of advanced research and development topics in photovoltaic that is summarized. The intent was to develop priorities in a list of advanced research and development activities. Thirty-five activities in 10 major categories were evaluated by their contributions to basic scientific advances, potential impact on further technology development by private industry, and priorities for federal advanced research and development funding.

Research University STEM Faculty Members' Motivation to Engage in Teaching Professional Development: Building the Choir Through an Appeal to Extrinsic Motivation and Ego

NASA Astrophysics Data System (ADS)

Bouwma-Gearhart, Jana

2012-10-01

This paper reports on a qualitative, grounded-theory-based study that explored the motivations of science and engineering faculty to engage in teaching professional development at a major research university. Faculty members were motivated to engage in teaching professional development due to extrinsic motivations, mainly a weakened professional ego, and sought to bring their teaching identities in better concordance with their researcher identities. The results pose a challenge to a body of research that has concluded that faculty must be intrinsically motivated to participate in teaching professional development. Results confirmed a pre-espoused theory of motivation, self-determination theory; a discussion of research literature consideration during grounded theory research is offered. A framework for motivating more faculty members at research universities to engage in teaching professional development is provided.

Developing a military nurse scientist program of research: A military women's health exemplar.

PubMed

Trego, Lori Lyn

Developing a feasible, fundable, and sustainable program of research (POR) is an essential career goal in research. Nurse scientists can lay the foundation for a salient POR as early as during their doctoral studies. The ensuing years of postdoctoral experiences are informative as they expand their research skills and knowledge around their research area of interest. Following graduation from a doctoral research program, novice military nurse scientists (MNS) are placed in positions that are conducive to fostering a POR. Military organizational support and the rich experiences of peers and mentors facilitate early career development of MNS. The purpose of this article is to present a conceptual framework for research career development of the novice MNS. Using an exemplar POR in military women's health, the concepts are operationalized to illustrate how the military environment enhances the development of a successful POR. Copyright © 2017 Elsevier Inc. All rights reserved.

A web-based portfolio model as the students' final assignment: Dealing with the development of higher education trend

NASA Astrophysics Data System (ADS)

Utanto, Yuli; Widhanarto, Ghanis Putra; Maretta, Yoris Adi

2017-03-01

This study aims to develop a web-based portfolio model. The model developed in this study could reveal the effectiveness of the new model in experiments conducted at research respondents in the department of curriculum and educational technology FIP Unnes. In particular, the further research objectives to be achieved through this development of research, namely: (1) Describing the process of implementing a portfolio in a web-based model; (2) Assessing the effectiveness of web-based portfolio model for the final task, especially in Web-Based Learning courses. This type of research is the development of research Borg and Gall (2008: 589) says "educational research and development (R & D) is a process used to develop and validate educational production". The series of research and development carried out starting with exploration and conceptual studies, followed by testing and evaluation, and also implementation. For the data analysis, the technique used is simple descriptive analysis, analysis of learning completeness, which then followed by prerequisite test for normality and homogeneity to do T - test. Based on the data analysis, it was concluded that: (1) a web-based portfolio model can be applied to learning process in higher education; (2) The effectiveness of web-based portfolio model with field data from the respondents of large group trial participants (field trial), the number of respondents who reached mastery learning (a score of 60 and above) were 24 people (92.3%) in which it indicates that the web-based portfolio model is effective. The conclusion of this study is that a web-based portfolio model is effective. The implications of the research development of this model, the next researcher is expected to be able to use the guideline of the development model based on the research that has already been conducted to be developed on other subjects.

Global Vaccine and Immunization Research Forum: Opportunities and challenges in vaccine discovery, development, and delivery.

PubMed

Ford, Andrew Q; Touchette, Nancy; Hall, B Fenton; Hwang, Angela; Hombach, Joachim

2016-03-18

The World Health Organization, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and the Bill & Melinda Gates Foundation convened the first Global Vaccine and Immunization Research Forum (GVIRF) in March 2014. This first GVIRF aimed to track recent progress of the Global Vaccine Action Plan research and development agenda, identify opportunities and challenges, promote partnerships in vaccine research, and facilitate the inclusion of all stakeholders in vaccine research and development. Leading scientists, vaccine developers, and public health officials from around the world discussed scientific and technical challenges in vaccine development, research to improve the impact of immunization, and regulatory issues. This report summarizes the discussions and conclusions from the forum participants. Copyright © 2016. Published by Elsevier Ltd.. All rights reserved.

Research and Development of High Energy 2 - Micron Lasers Based on TM: Doped Ceramic Laser Gain Media and TM: Doped Optical Fibers

DTIC Science & Technology

2016-07-20

AFRL-AFOSR-VA-TR-2016-0257 RESEARCH AND DEVELOPMENT OF HIGH ENERGY 2 - MICRON LASERS BASED ON TM: DOPED CERAMIC LASER GAIN MEDIA AND TM: DOPED...2010 to 01/03/2016 4. TITLE AND SUBTITLE RESEARCH AND DEVELOPMENT OF HIGH ENERGY 2 - MICRON LASERS BASED ON TM: DOPED CERAMIC LASER GAIN MEDIA AND...NOTES 14. ABSTRACT Our research and development of 2-μm femtosecond lasers has included development of mode-locked Tm:fiber lasers , super-continuum

Microgravity: New opportunities to facilitate biotechnology development

NASA Astrophysics Data System (ADS)

Johnson, Terry; Todd, Paul; Stodieck, Louis S.

1996-03-01

New opportunities exist to use the microgravity environment to facilitate biotechnology development. BioServe Space Technologies Center for the Commercial Development of Space offers access to microgravity environments for companies who wish to perform research or develop products in three specific life-science fields: Biomedical and Pharmaceutical Research, Biotechnology and Bioprocessing Research, and Agricultural and Environmental Research. Examples of each include physiological testing of new pharmaceutical countermeasures against symptoms that are exaggerated in space flight, crystallization and testing of novel, precompetitive biopharmaceutical substances in a convection-free environment, and closed life-support system product development.

77 FR 22334 - Authority To Accept Unsolicited Research Proposals

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-13

... Unsolicited Research Proposals AGENCY: Office of the Assistant Secretary for Policy Development and Research, HUD. ACTION: Notice: Authority to accept unsolicited proposals for research partnerships. SUMMARY: This notice announces that HUD's Office of Policy Development and Research has the authority to accept...

78 FR 50144 - Health Services Research and Development Service, Scientific Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... Organization and Delivery; Research Methods and Models on August 27-28, 2013, at the VHA National Conference... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service, Scientific Merit... Advisory Committee Act, 5 U.S.C. App. 2, that the Health Services Research and Development Service (HSR&D...

To Explore the Research and Development Competence and School-to-Work Transition for Hospitality Students

ERIC Educational Resources Information Center

Ko, Wen-Hwa; Chen, Chieh-Ying

2017-01-01

This research focuses on the research and development competence and school-to-work transition on occupation selection for hospitality students with the use of social cognitive career theory. The positive attitude construct is the most identifiable for the research and development competences. For the school-to-work constructs, the most…

Research Directions for the 70's in Child Development.

ERIC Educational Resources Information Center

Sparling, Joseph J.; Gallagher, James J.

This booklet is based on a series of 1971 conferences attended by 22 prominent individuals in the field of child development research. Conference participants met in three working panels (on infancy, the preschool child, and the school age child) to assess the current status of the child development research field and to project research needs for…

Operational Test and Evaluation Manual

DTIC Science & Technology

2011-06-28

Fiscal Office manages all funds received throughout the year for Operations and Maintenance Marine Corps (O&MMC); Research , Development, Test, and... Research , Development, and Acquisition) Assistant Secretary of the Navy ( Research , Development, and Acquisition) (ASN (RDA)) is the DOD’s Component...entire acquisition cycle (SECNAV 2008). This accumulation of data starts with early research and developmental testing and Other tests and

75 FR 39734 - Health Services Research and Development Service Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-12

... from 8 a.m. to 5 p.m. On September 2, the subcommittee on Health Services Research 7 for Pilot Proposal... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Merit Review Board... Advisory Committee Act) that a meeting of the Health Services Research and Development Service Merit Review...

Welcome to Our World: Bridging Youth Development Research in Nonprofit and Academic Communities

ERIC Educational Resources Information Center

Bialeschki, M. Deborah; Conn, Michael

2011-01-01

This commentary discusses the emergence of youth development research and evaluation in the nonprofit arena over the past 10 to 15 years. Included in this discussion is the establishment of the context for youth development research in nonprofits, a brief description of key examples of research from three youth nonprofits that illustrate the…

Sex, pain and cranberries - ideas from the 2006 Registrar Research Workshop.

PubMed

Montgomery, Brett D; McMeniman, Erin; Cameron, Sara Kate; Duncan, Tristram; Prosser, Stuart; Moore, Ray

2007-01-01

The Registrar Research Workshop has been a feature of Australian general practice training since 1994. Twenty five general practice registrars attend the annual 3 day event, which aims to develop registrars' understanding of the research process. Presenters and facilitators are drawn from the academic general practitioner and primary health care research community. Presentations alternate with small group sessions, where groups of five registrars are guided through the process of developing a research question, identifying appropriate research methods, and addressing ethical and funding concerns, before preparing a presentation about their research proposal for their peers. Research questions are developed from unanswered questions that have arisen in registrars' clinical practice.

Getting from A to IRB: developing an institutional review board at a historically black university.

PubMed

Howard, Daniel L; Boyd, Carlton L; Nelson, Daniel K; Godley, Paul

2010-03-01

Shaw University, the oldest historically black college or university in the southern USA, recently partnered with the University of North Carolina at Chapel Hill, a major research institution in North Carolina, to further develop Shaw's research infrastructure. One aim of the partnership involved establishing a human research ethics committee and an accompanying administrative structure and research ethics education program. This paper describes the process of developing an entire human research protection program de novo through collaboration with and mentoring by the members of the human research protection program at a nearby major research institution. This paper provides a detailed description of the aims, procedures, accomplishments, and challenges involved in such a project, which may serve as a useful model for other primarily teaching institutions wishing to develop research infrastructure and ethical capacity.

Getting From A to IRB: Developing an Institutional Review Board at a Historically Black University

PubMed Central

Howard, Daniel L.; Boyd, Carlton L.; Nelson, Daniel K.; Godley, Paul

2011-01-01

Shaw University, the oldest historically black college or university in the southern USA, recently partnered with the University of North Carolina at Chapel Hill, a major research institution in North Carolina, to further develop Shaw’s research infrastructure. One aim of the partnership involved establishing a human research ethics committee and an accompanying administrative structure and research ethics education program. This paper describes the process of developing an entire human research protection program de novo through collaboration with and mentoring by the members of the human research protection program at a nearby major research institution. This paper provides a detailed description of the aims, procedures, accomplishments, and challenges involved in such a project, which may serve as a useful model for other primarily teaching institutions wishing to develop research infrastructure and ethical capacity. PMID:20235865

40 CFR 80.160 - Exemptions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.160 Exemptions. (a) Research, development, and testing...

40 CFR 80.160 - Exemptions.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.160 Exemptions. (a) Research, development, and testing...

40 CFR 80.160 - Exemptions.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.160 Exemptions. (a) Research, development, and testing...

40 CFR 80.173 - Exemptions.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.173 Exemptions. (a) Research, development, and testing...

40 CFR 80.173 - Exemptions.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.173 Exemptions. (a) Research, development, and testing...

40 CFR 80.173 - Exemptions.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.173 Exemptions. (a) Research, development, and testing...

40 CFR 80.160 - Exemptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.160 Exemptions. (a) Research, development, and testing...

40 CFR 80.160 - Exemptions.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.160 Exemptions. (a) Research, development, and testing...

40 CFR 80.173 - Exemptions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.173 Exemptions. (a) Research, development, and testing...

40 CFR 80.173 - Exemptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., automobile, engine, or component manufacturers for research, development, or test purposes, or any gasoline... such facility is associated with detergent, fuel, automotive, or engine research, development or... FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.173 Exemptions. (a) Research, development, and testing...

3 CFR - Expanding America's Leadership in Wireless Innovation

Code of Federal Regulations, 2014 CFR

2014-01-01

... results from the Networking and Information Technology Research and Development Program, shall publish an... in research, development, testing, and evaluation of technologies to enhance spectrum sharing and... templates governing the following: research, development, testing, and evaluation of spectrum sharing...

Developing a strategy to promote the generation and effective use of population health research for NSW Health: 2011-2015.

PubMed

Biggs, Janice S; Stickney, Beth

2011-04-01

The Population Health Division of the NSW Department of Health has developed a 5-year strategy to improve the effectiveness of its resource investment in population health research. This paper describes the development of the strategy, Promoting the generation and effective use of population health research in NSW: a Strategy for NSW Health 2011-2015. A review of Australian and international strategic research documents and stakeholder interviews was conducted to support the development of the strategy. The findings from these two processes influenced the structure of the document and supported the inclusion of strategies and actions to assist with identifying research priorities, improving communication, enhancing networks and partnerships, supporting workforce development initiatives, providing research infrastructure, enhancing research and the use of research evidence and streamlining research governance and ethics processes. Small group discussions and a detailed review of literature were conducted to refine the thinking around four of the more complex aspects of the strategy. Finally, a broad consultation process was used to test the face validity of the proposed strategy content.

48 CFR 970.3102-05-18 - Independent research and development and bid and proposal costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... development and bid and proposal costs. 970.3102-05-18 Section 970.3102-05-18 Federal Acquisition Regulations... Contract Cost Principles and Procedures 970.3102-05-18 Independent research and development and bid and proposal costs. (c) Independent Research and Development and Bid and Proposal costs are unallowable...

Students in Transition: Research and Practice in Career Development. The First-Year Experience Monograph Series No. 55

ERIC Educational Resources Information Center

Gore, Paul A., Jr., Ed.; Carter, Louisa P., Ed.

2011-01-01

Offering a primer on action research methodologies and examples of practice, "Students in Transition: Research and Practice in Career Development" responds to a dual challenge facing career development educators--designing cutting-edge career development interventions and demonstrating their effectiveness. Overviews of quantitative and qualitative…

Developing Automated Feedback Materials for a Training Simulator: An Interaction between Users and Researchers.

ERIC Educational Resources Information Center

Shlechter, Theodore M.; And Others

This paper focuses upon the research and development (R&D) process associated with developing automated feedback materials for the SIMulation NETworking (SIMNET) training system. This R&D process involved a partnership among instructional developers, practitioners, and researchers. Users' input has been utilized to help: (1) design the…

"Everybody Kind of Looked at Me Like I Was from Mars:" Preparing Educators through Qualitative Service-Research Projects

ERIC Educational Resources Information Center

Dorner, Lisa M.; Kim, Sujin; Floros, Alice; Mujanovic, Midheta

2017-01-01

Skills developed through qualitative research and community partnerships can be essential for developing education students' cultural competency and understandings about diverse student populations. Toward this end, we developed a qualitative "service-research" project in a teacher education course focused on child development, whereby…

Tertiary Educational Institutions for Teaching, Research and Development

ERIC Educational Resources Information Center

Amoo, Sikiru A.

2014-01-01

This paper examines the quality of teaching and research in developing human resources to facilitate the development of tertiary education in the nation. It discusses the challenges and the roles of research in higher education. The author argues that the combination of content and pedagogical knowledge could help to develop human resources for…